Search of human proteins with 144226847

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|144226847 obscurin-like 1 [Homo sapiens]
         (1896 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|144226847 obscurin-like 1 [Homo sapiens]                          3848   0.0  
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact...   858   0.0  
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac...   858   0.0  
gi|110349719 titin isoform N2-A [Homo sapiens]                        461   e-129
gi|110349717 titin isoform novex-2 [Homo sapiens]                     461   e-129
gi|110349713 titin isoform novex-1 [Homo sapiens]                     461   e-129
gi|110349715 titin isoform N2-B [Homo sapiens]                        461   e-129
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   321   4e-87
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   321   5e-87
gi|118572606 hemicentin 1 [Homo sapiens]                              301   3e-81
gi|110349721 titin isoform novex-3 [Homo sapiens]                     291   4e-78
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   251   6e-66
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            224   8e-58
gi|157785645 SPEG complex locus [Homo sapiens]                        164   6e-40
gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens]     145   4e-34
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        143   1e-33
gi|133908641 myosin binding protein C, fast type [Homo sapiens]       125   5e-28
gi|148596957 myosin binding protein C, cardiac [Homo sapiens]         124   7e-28
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   117   1e-25
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   117   1e-25
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   117   1e-25
gi|46049110 myosin binding protein C, slow type isoform 4 [Homo ...   116   2e-25
gi|46049119 myosin binding protein C, slow type isoform 3 [Homo ...   116   2e-25
gi|46049125 myosin binding protein C, slow type isoform 2 [Homo ...   116   2e-25
gi|45976288 myosin binding protein C, slow type isoform 1 [Homo ...   116   2e-25
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     112   3e-24
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      112   3e-24
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  111   6e-24
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]      110   1e-23
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]       110   1e-23

>gi|144226847 obscurin-like 1 [Homo sapiens]
          Length = 1896

 Score = 3848 bits (9979), Expect = 0.0
 Identities = 1896/1896 (100%), Positives = 1896/1896 (100%)

Query: 1    MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 60
            MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF
Sbjct: 1    MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 60

Query: 61   PADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS 120
            PADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS
Sbjct: 61   PADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS 120

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
            PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ
Sbjct: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ 180

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240
            PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA
Sbjct: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240

Query: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
            PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG
Sbjct: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVL 360
            GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVL
Sbjct: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVL 360

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420
            ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT
Sbjct: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420

Query: 421  VANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMH 480
            VANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMH
Sbjct: 421  VANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMH 480

Query: 481  ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKP 540
            ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKP
Sbjct: 481  ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKP 540

Query: 541  PEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
            PEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR
Sbjct: 541  PEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600

Query: 601  SPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPE 660
            SPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPE
Sbjct: 601  SPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPE 660

Query: 661  GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSP 720
            GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSP
Sbjct: 661  GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSP 720

Query: 721  QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKV 780
            QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKV
Sbjct: 721  QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKV 780

Query: 781  QDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRW 840
            QDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRW
Sbjct: 781  QDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRW 840

Query: 841  YKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIV 900
            YKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIV
Sbjct: 841  YKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIV 900

Query: 901  YPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960
            YPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV
Sbjct: 901  YPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960

Query: 961  QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV 1020
            QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV
Sbjct: 961  QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV 1020

Query: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
            RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER
Sbjct: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080

Query: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140
            IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL
Sbjct: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140

Query: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 1200
            PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA
Sbjct: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 1200

Query: 1201 GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV 1260
            GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV
Sbjct: 1201 GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV 1260

Query: 1261 QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA 1320
            QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA
Sbjct: 1261 QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA 1320

Query: 1321 GARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
            GARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR
Sbjct: 1321 GARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380

Query: 1381 CEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA 1440
            CEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA
Sbjct: 1381 CEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA 1440

Query: 1441 RLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQ 1500
            RLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQ
Sbjct: 1441 RLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQ 1500

Query: 1501 DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ 1560
            DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ
Sbjct: 1501 DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ 1560

Query: 1561 LELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAA 1620
            LELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAA
Sbjct: 1561 LELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAA 1620

Query: 1621 RLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALG 1680
            RLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALG
Sbjct: 1621 RLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALG 1680

Query: 1681 TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC 1740
            TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC
Sbjct: 1681 TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC 1740

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLAL 1800
            TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLAL
Sbjct: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLAL 1800

Query: 1801 LEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860
            LEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG
Sbjct: 1801 LEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860

Query: 1861 PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEGN 1896
            PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEGN
Sbjct: 1861 PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEGN 1896


>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform a [Homo sapiens]
          Length = 6620

 Score =  858 bits (2217), Expect = 0.0
 Identities = 585/1939 (30%), Positives = 896/1939 (46%), Gaps = 112/1939 (5%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P FL  P+   V  G +A L C ++G P P V WEK  Q +AA  R     DG  + L +
Sbjct: 10   PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
                  D+G YVCRARNA GEA+AA  + V      D E   AE+          AP FL
Sbjct: 70   LDLALGDSGQYVCRARNAIGEAFAAVGLQV------DAEAACAEQ----------APHFL 113

Query: 132  TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP--- 188
              P S  V  G+E    CR GG P P + W KDG  L E               DGP   
Sbjct: 114  LRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGE--------------PDGPRVR 159

Query: 189  ----GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPV 244
                G + ALRI AAR  D G Y   A N  G A A A L V        + P  + A +
Sbjct: 160  VEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAAL 219

Query: 245  V-----------------EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
            +                  P     +T  V EGKHA+  CYV G+P+PE  W  +G+ + 
Sbjct: 220  LAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVT 279

Query: 288  PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPL 347
              RR ++Y D    FVLK+L+C+  DRGLY C A N  GQT S+V + V+EP + F + L
Sbjct: 280  EGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRL 339

Query: 348  QDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDD 407
            QD+E RE   A   C+VP      AWF+E+ RL    KY   EEGT RRL +  + ADDD
Sbjct: 340  QDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDD 399

Query: 408  GIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEE 467
             +Y+CE     RTVA + V+G +L++LPRK  V  G+ A+  VE         W R+ EE
Sbjct: 400  AVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEE 459

Query: 468  LPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILA 524
            +     +  S+ G  H L +     ED G+V F  G+ +T+T   V   +  P  PP+  
Sbjct: 460  VVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDP 519

Query: 525  EMFKGHKNTVLLTWKPPEPAPETPFI---YRLERQEVGSEDWIQCFSIEKAGAVEVPGDC 581
             +    +++V+L+W PP P  E P     Y +E++++G+  WI+C   E     E+    
Sbjct: 520  VVKARMESSVILSWSPP-PHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVAD 578

Query: 582  VPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLST 641
            V  EG+++FR+  ++  G+SP++ F G+ HL P   +   L+ VQ  +G +  FS+DL+ 
Sbjct: 579  VAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTV 638

Query: 642  IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPG 701
               G WFL+G+ LK++            Y I     +H L +  V     GA + F   G
Sbjct: 639  ASAGEWFLDGQALKASSV----------YEIHCDRTRHTLTIREVPASLHGAQLKFVANG 688

Query: 702  VQDSAALTIQESPVHILSPQDRVS---LTFTTSERVVLTCELSRVDFPATWYKDGQKVEE 758
            ++ S  + ++ +P    +     +   +     E   L  ELS      TW KDG+ +  
Sbjct: 689  IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSP 748

Query: 759  SELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
                 V+    +  L++ +    D+G +EC + G    + ++VQ     +        V 
Sbjct: 749  GPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVD 808

Query: 819  AITSECVMLACEVDREDAPVRWYKDGQEVEES-DFVVLENEGPHRRLVLPATQPSDGGEF 877
            A+        CE       V WYKDG E+  S +  + E+ G   RLV       D G +
Sbjct: 809  AVAGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTY 868

Query: 878  QCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLE---RVVLTCELCRPWAEVRWTKD 934
             C  G++   F + +++    +V+   ++    ++ E      L+CE+ +   EV W KD
Sbjct: 869  SCRVGEDSVDFRLRVSEPK--VVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKD 926

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPR 994
            G+++  S  + ++     RRLV+      D+GEY CE   +  SF + V EP  ++++ +
Sbjct: 927  GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEP--KVVFAK 984

Query: 995  DEVTLIAVTLEC---VVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAA 1051
            D+V    V  E      L CE+++    V WYKDG ++  S  + +E  G R RLV+  A
Sbjct: 985  DQVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQA 1044

Query: 1052 QPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ 1111
               D G++ C+A      F + +T P        +   ++   A     L CEVA A ++
Sbjct: 1045 GKTDAGDYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTE 1104

Query: 1112 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPV 1171
            V WYKDG ++ +S  + +  +G TR L LP A   DAGEY CE   + ++F++ + EP  
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPKG 1164

Query: 1172 QFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLC 1231
             F   ++  + +    G   +LSCE+++    V W  +G+ +     + +  +G  R L 
Sbjct: 1165 VFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLV 1224

Query: 1232 IQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVV 1291
            +Q  G A AG Y+C++    G   +SF + + EP       +     VR+  G    L  
Sbjct: 1225 VQQVGKADAGEYSCEA----GGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSC 1280

Query: 1292 HLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL 1351
             ++     V WYKDG++L+S  +V++E AG  + L VQ A   DAGEY C+A      F 
Sbjct: 1281 EVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFH 1340

Query: 1352 VSVEEPLLVKLVSELT--PLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQ 1409
            + V EP  V    +L    +    G  AT  CEV+    +VTW ++G  ++   +V M  
Sbjct: 1341 LDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEA 1400

Query: 1410 NGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRL---QDVRAEEGQDV 1466
             G +R L ++     D G  +  AG    S  L V E +++F +     ++V+A+ G   
Sbjct: 1401 VGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGAST 1460

Query: 1467 CLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH 1526
             L  E  +  A   V W + G+ L   S++ M   G   RL +     A  G Y CE+  
Sbjct: 1461 TLSCEVAQ--AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518

Query: 1527 DRTLARLSV-RPRQL--RVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGP 1583
             R    L V  P+ +  +      +V    G SAT   E++Q      W + G +L    
Sbjct: 1519 QRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSS 1578

Query: 1584 KCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVR---GPHDLEV 1640
            K  + + G   RLV+   G AD+G  S  A   R +  L V E  V   +      +++ 
Sbjct: 1579 KVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQA 1638

Query: 1641 TEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
              G +AT  CE++QA  +VTW KDG  L+ S ++R++A+G  R L +++ G +DAG YSC
Sbjct: 1639 EAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC 1698

Query: 1701 AVGTARAGPVRLTVRERTVAVLS---ELRSVSAREGDGATFECTVSEVE-TTGRWELGGR 1756
              G  R    RL V E    +         +  +E +      T++     T  W   G 
Sbjct: 1699 EAGGQRLS-FRLHVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGV 1757

Query: 1757 PLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCR--HP 1814
             +R   R     +G  H L +   +  D+     + G       ++VE +  + CR   P
Sbjct: 1758 EIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEP 1817

Query: 1815 PREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPED 1874
               +   +G    L   +S +   V W     +L  G +++M + GP  SL +  +R ED
Sbjct: 1818 VCGE---LGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAED 1874

Query: 1875 QGTYCCQAGQDSTHTRLLV 1893
             G Y C++  D T  +L V
Sbjct: 1875 AGEYVCESRDDHTSAQLTV 1893



 Score =  621 bits (1602), Expect = e-177
 Identities = 473/1604 (29%), Positives = 723/1604 (45%), Gaps = 80/1604 (4%)

Query: 330  SAVQLHVKE-PRLRFTRP----LQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCR 384
            S++++ V+  P L   +P     ++V  R H  A L  ++ +      W ++ + L P  
Sbjct: 691  SSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGP 750

Query: 385  KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRK------L 438
            KYE       R L++  +  DD G+Y C  RG  R    ++V+G  L R   K      +
Sbjct: 751  KYEVQASAGRRVLLVRDVARDDAGLYECVSRGG-RIAYQLSVQG--LARFLHKDMAGSCV 807

Query: 439  DVLEGENAVLLVETLEAGVEGRWSRDGEEL----PVICQSSSGHMHALVLPGVTREDAGE 494
            D + G  A    ET EA V   W +DG EL        Q   G  H LV   VTR+D G 
Sbjct: 808  DAVAGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGT 867

Query: 495  VTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHK------NTVLLTWKPPEPAPETP 548
             +  +G       LRV     S P      E     K       +  L+ +  +   E  
Sbjct: 868  YSCRVGEDSVDFRLRV-----SEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVT 922

Query: 549  FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHG 608
            +    ++    S+  ++     +   V+  G      G+Y    C   G   S H+    
Sbjct: 923  WYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQA--DAGEYS---CEAGGQRLSFHLDVKE 977

Query: 609  SAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGA 667
                V  A+      +VQ   G  A  S +++    +  W+ +G++L S+          
Sbjct: 978  PK--VVFAKDQVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSS---------- 1025

Query: 668  LRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESPVHILSPQD-RV 724
            L+  +E KG + RL++      D+G    +SC   G + S  L I E  +     Q    
Sbjct: 1026 LKVHVEAKGCRRRLVVQQAGKTDAG---DYSCEARGQRVSFRLHITEPKMMFAKEQSVHN 1082

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
             +        +L+CE+++     TWYKDG+K+  S  + +++ G   RL+LP+A   D+G
Sbjct: 1083 EVQAEAGASAMLSCEVAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAG 1142

Query: 785  EFECRTEGVSAFFGVTVQDPP-VHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKD 843
            E+ C   G    F + + +P  V   +   H  V A      ML+CEV +    V WYKD
Sbjct: 1143 EYSCEAGGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKD 1202

Query: 844  GQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPS 903
            G+++  S  V +E +G  RRLV+     +D GE+ C AG +   F + IT+  +  V+  
Sbjct: 1203 GKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKA--VFAK 1260

Query: 904  GKVYVAAVRLER---VVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960
             ++    VR E      L+CE+ +   EV W KDG+++  S  + ++    +R+LV+   
Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320

Query: 961  QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLEC---VVLMCELSRED 1017
               D+GEY CE   +  SF + V+EP  + ++ ++++    V  E      L CE+++  
Sbjct: 1321 GQADAGEYTCEAGGQRLSFHLDVSEP--KAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQ 1378

Query: 1018 APVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAP 1077
              V WYKDG ++  S  + +E  G   RLV+  A   D GE+ C+AG     F++ V  P
Sbjct: 1379 TEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEP 1438

Query: 1078 PERIV--HPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPT 1135
                    P  R +    GA     L CEVA A ++V WYKDG ++  S  +++ A G T
Sbjct: 1439 KVVFAKEQPVHREVQAQAGAS--TTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCT 1496

Query: 1136 RTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSC 1195
            R L +  A    AGEY CE   + ++F++ +AEP   F   +     +    G    LSC
Sbjct: 1497 RRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSC 1556

Query: 1196 ELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPS 1255
            E+++A   V W  +G+ +     + + A G  R L +Q AG A AG Y+C++G       
Sbjct: 1557 EVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ----R 1612

Query: 1256 LSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRV 1315
            LSF + VAEP V     + A   V++  G    L   ++     V WYKDG++L+S  +V
Sbjct: 1613 LSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKV 1672

Query: 1316 QLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEE--PLLVKLVSELTPLTVHE 1373
            ++E  G  + L VQ A   DAGEY C+A      F + V E  P + +      PL V E
Sbjct: 1673 RVEAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISERPCRREPLVVKE 1732

Query: 1374 GDDATFRCEVSPPDA-DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
             +D      ++ P A  VTWL++G  +    + E A  G +  LT+ G Q+ D+   + R
Sbjct: 1733 HEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR 1792

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
             G+      + V E    F R L+ V  E G  V L  E     A   V W  G   L  
Sbjct: 1793 VGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSP--ACAEVVWRCGNTQLRV 1850

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVR-PRQLRVLRPLEDVTI 1551
              R  M  +G +  L + G+   D G Y CES  D T A+L+V  PR ++ +  L  V  
Sbjct: 1851 GKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVA 1910

Query: 1552 SEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSF 1611
             EGG ATFQ  +S   V   W R G  L P  K  I   G  H L ++ L L D+G ++ 
Sbjct: 1911 EEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITV 1970

Query: 1612 TADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPS 1671
             A+    +A L VRE PV   +      V E  + T E EL++   ++ W ++  AL P 
Sbjct: 1971 EAEGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPG 2030

Query: 1672 PRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAR 1731
              + + A G R  L L   G +D G + C     +    +LTV  R V ++  L++V AR
Sbjct: 2031 KNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKT-QAKLTVEMRQVRLVRGLQAVEAR 2089

Query: 1732 EGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ 1791
            E   AT E  +S  +  G W   G   + G    +   G  H L LS LR ED+G + F+
Sbjct: 2090 EQGTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFK 2149

Query: 1792 AGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPG 1851
            A    + A L V  LP+   R P ++       +  LE  +SR    V WL++G EL  G
Sbjct: 2150 AEGVHTSARLVVTELPVSFSR-PLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAG 2208

Query: 1852 DKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
                + + G   SL I+     DQG Y C A    +   + V+G
Sbjct: 2209 KTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQG 2252



 Score =  605 bits (1561), Expect = e-172
 Identities = 483/1704 (28%), Positives = 765/1704 (44%), Gaps = 121/1704 (7%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G  A+F C    +    + W+ +G  L     R +  D      L       +D G Y C
Sbjct: 812  GGPAQFECET-SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSC 870

Query: 320  AARNSAGQTLSAVQLHVKEPRLRFTRPL---QDVEGREHGIAVLECKVPNSRIPTAWFRE 376
                  G+     +L V EP++ F +     + ++      A L C+V  ++    W+++
Sbjct: 871  RV----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKD 926

Query: 377  DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL----- 431
             ++L    K      G  RRL++ +    D G Y CE  G+ R   ++ VK P +     
Sbjct: 927  GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQ-RLSFHLDVKEPKVVFAKD 985

Query: 432  KRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGVT 488
            +    ++    G +A L  E  +A  E  W +DG++L    +    + G    LV+    
Sbjct: 986  QVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAG 1045

Query: 489  REDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETP 548
            + DAG+ +      R +  L +         P ++    +   N V    +    A  + 
Sbjct: 1046 KTDAGDYSCEARGQRVSFRLHIT-------EPKMMFAKEQSVHNEVQA--EAGASAMLSC 1096

Query: 549  FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDC----VPSEG--DYRFRICTVSGHGRSP 602
             + + + +    +D  +  S  K G +EV G      +P  G  D     C   G   S 
Sbjct: 1097 EVAQAQTEVTWYKDGKKLSSSSKVG-MEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSF 1155

Query: 603  HVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEG 661
            H+  H +      A+  +   +VQ   G  A+ S +++    + TW+ +G++L S+    
Sbjct: 1156 HL--HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSS--- 1210

Query: 662  QVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESPVHILS 719
                   + R+E KG   RL++  V   D+G    +SC   G + S  L I E P  + +
Sbjct: 1211 -------KVRMEVKGCTRRLVVQQVGKADAGE---YSCEAGGQRVSFQLHITE-PKAVFA 1259

Query: 720  PQDRVSLTFTTSE--RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPE 777
             +  V     T       L+CE+++     TWYKDG+K+  S  + ++  G   +L++ +
Sbjct: 1260 KEQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQ 1319

Query: 778  AKVQDSGEFECRTEGVSAFFGVTVQDPP-VHIVDPREHVFVHAITSECVMLACEVDREDA 836
            A   D+GE+ C   G    F + V +P  V   +   H  V A       L+CEV +   
Sbjct: 1320 AGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQT 1379

Query: 837  PVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVS 896
             V WYKDG+++  S  V +E  G  RRLV+     +D GE+ C AG +   F++ + +  
Sbjct: 1380 EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPK 1439

Query: 897  SWIVYPSGKVYVAAVRLER---VVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVR 953
              +V+   +     V+ +      L+CE+ +   EV W KDG+++  S  + ++     R
Sbjct: 1440 --VVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTR 1497

Query: 954  RLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLEC---VVLM 1010
            RLV+       +GEY CE   +  SF + V EP  + ++ +++     V  E      L 
Sbjct: 1498 RLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEP--KAVFAKEQPASREVQAEAGTSATLS 1555

Query: 1011 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 1070
            CE+++    V WYKDG ++  S  + +E  G   RLV+  A   D GE+ C AGD    F
Sbjct: 1556 CEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSF 1615

Query: 1071 TVTVTAPPERIV--HPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQ 1128
             + V  P        PA R +    GA     L CEVA A ++V WYKDG ++ +S  ++
Sbjct: 1616 HLHVAEPKVVFAKEQPAHREVQAEAGASAT--LSCEVAQAQTEVTWYKDGKKLSSSSKVR 1673

Query: 1129 LGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPG 1188
            + A G TR L +  A   DAGEY CE   + ++F + +AE   Q         PL V   
Sbjct: 1674 VEAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISERPCRREPLVVKEH 1733

Query: 1189 EPVVLSCELSR-AGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
            E ++L+  L+  + A V W  +G  ++  +  E  ++G    L +  A    + +Y+C+ 
Sbjct: 1734 EDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRV 1793

Query: 1248 GAAPGAPSLSFTVQVAEPPV---RVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYK 1304
            GA        F VQV E      R++ P   +       GG + L   LS     V W  
Sbjct: 1794 GAE----GQDFPVQVEEVAAKFCRLLEPVCGEL------GGTVTLACELSPACAEVVWRC 1843

Query: 1305 DGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVS 1364
               +L    R Q+   G  + L V G R+ DAGEY+C++  D     ++V  P +VK +S
Sbjct: 1844 GNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMS 1903

Query: 1365 ELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             L+ +   EG +ATF+C VSP D  V W R+GA++ P  +  ++Q+G+S  LT+    L 
Sbjct: 1904 GLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLE 1963

Query: 1425 DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWV 1484
            DAG +T+ A   ++SA L VRE  +LF ++L+    EE   V LEVE  R      +RW 
Sbjct: 1964 DAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPE--LRWT 2021

Query: 1485 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            R    L     + +  +G  HRL +H V  AD+G +GCE+  D+T A+L+V  RQ+R++R
Sbjct: 2022 RNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVR 2081

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLA 1604
             L+ V   E G+AT +++LS   V G W R G++   GP CH+   G  H L L+GL   
Sbjct: 2082 GLQAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPE 2141

Query: 1605 DSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKD 1664
            DSG + F A+ +  +ARL+V E+PV+  R   D+  TE +  T ECELS+   DV W KD
Sbjct: 2142 DSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKD 2201

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR------------------ 1706
            G  L     + + A G  R L + RC  +D G Y C    A+                  
Sbjct: 2202 GVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRR 2261

Query: 1707 -----AGPV-----------RLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGR 1750
                 AG +           +L V+E  V ++  LR   A E      EC VS      R
Sbjct: 2262 VLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVR 2321

Query: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQM 1810
            W  G + L+PG +  +  +G    L++S++ AED       AG  ++ A   VE   + +
Sbjct: 2322 WFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFFVEEQSITI 2381

Query: 1811 CRHPPREKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHD 1869
             R   ++ TV+    A  E   S  S     WL     L  G    +   G  H L++  
Sbjct: 2382 VR-GLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRR 2440

Query: 1870 VRPEDQGTYCCQAGQDSTHTRLLV 1893
                  G      G+  +  RL+V
Sbjct: 2441 TCSTMTGPVHFTVGKSRSSARLVV 2464



 Score =  499 bits (1284), Expect = e-140
 Identities = 511/1946 (26%), Positives = 789/1946 (40%), Gaps = 189/1946 (9%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V+  +GA A L C V  +    V W K G++L++S ++     G    L+L  A   DAG
Sbjct: 1084 VQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAG 1142

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
             Y C A    G    +  + + EP     + Q     + +                    
Sbjct: 1143 EYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEA------------------ 1180

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
             G   +L+C     P+  + W KDG  L     SS   ++        G +  L +    
Sbjct: 1181 -GTTAMLSCEVAQ-PQTEVTWYKDGKKLSS---SSKVRMEV------KGCTRRLVVQQVG 1229

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEG 260
              D+G Y C A    G  +    L + +P              V    +          G
Sbjct: 1230 KADAGEYSCEA----GGQRVSFQLHITEPKA------------VFAKEQLVHNEVRTEAG 1273

Query: 261  KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA--KDRGLYV 318
              A   C V  + + E+ W+ +G+ L    +    R    G + +++  QA   D G Y 
Sbjct: 1274 ASATLSCEV-AQAQTEVTWYKDGKKLSSSSK---VRIEAAGCMRQLVVQQAGQADAGEYT 1329

Query: 319  CAARNSAGQTLSAVQLHVKEPRLRFTRPL---QDVEGREHGIAVLECKVPNSRIPTAWFR 375
            C A    GQ LS   L V EP+  F +     + V+     IA L C+V  ++    W++
Sbjct: 1330 CEA---GGQRLS-FHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYK 1385

Query: 376  EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP---ILK 432
            + ++L    K      G  RRL++ +    D G Y CE  G+ R   ++ V  P     K
Sbjct: 1386 DGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQ-RLSFSLDVAEPKVVFAK 1444

Query: 433  RLP--RKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGV 487
              P  R++    G +  L  E  +A  E  W +DG++L     +   + G    LV+   
Sbjct: 1445 EQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQA 1504

Query: 488  TREDAGEVTFSLGNSRTTTLLRV---KCV--KHSPPGPPILAEMFKGHKNTVLLTWKPPE 542
             +  AGE +   G+ R +  L V   K V  K  P    + AE       +  L+ +  +
Sbjct: 1505 GQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEA----GTSATLSCEVAQ 1560

Query: 543  PAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSE-----GDYRFRICTVSG 597
               E  +    ++    S+  ++     +   V+  G     E     GD R        
Sbjct: 1561 AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHL--- 1617

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKS 656
            H   P VVF         A+      +VQ   G  A  S +++    + TW+ +G++L S
Sbjct: 1618 HVAEPKVVF---------AKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSS 1668

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESP 714
            +           + R+E  G   RL++      D+G    +SC   G + S  L + E  
Sbjct: 1669 SS----------KVRVEAVGCTRRLVVQQAGQADAGE---YSCEAGGQRLSFRLHVAELE 1715

Query: 715  VHILS-PQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHR 772
              I   P  R  L     E ++LT  L+       TW KDG ++  S+       G  H 
Sbjct: 1716 PQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHT 1775

Query: 773  LILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSEC------VM 826
            L +  A+V DS  + CR        G   QD PV + +     F   +   C      V 
Sbjct: 1776 LTVHGAQVLDSAIYSCRV-------GAEGQDFPVQVEEVAAK-FCRLLEPVCGELGGTVT 1827

Query: 827  LACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
            LACE+    A V W     ++       +  EGP R L +   +  D GE+ C + D+  
Sbjct: 1828 LACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHT 1887

Query: 887  YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLL 946
               +T++ V   + + SG   V A         C +      V W +DG  +  S    +
Sbjct: 1888 SAQLTVS-VPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAI 1946

Query: 947  QKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPV---RIIYPRDEVTLIAVT 1003
             +      L +  + LED+G+   E +  S+S  + V E PV   + + P+      +VT
Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVEERSSVT 2006

Query: 1004 LECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
            LE      EL+R    +RW ++   +   + + +  +G R RLVL      D G F C+ 
Sbjct: 2007 LEV-----ELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCET 2061

Query: 1064 GDDSAFFTVTVTAPPERIVHPAARSLD-LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVE 1122
             DD     +TV     R+V    R L  +     G   +  +++ A     W +DGL  +
Sbjct: 2062 PDDKTQAKLTVEMRQVRLV----RGLQAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQ 2117

Query: 1123 ASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
                  L   GP  TLTL   +PED+G  V +      +  +++ E PV F         
Sbjct: 2118 QGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTELPVSF---SRPLQD 2174

Query: 1183 LCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGL 1242
            +     E V L CELSR    V W  +G  ++ G+ + + A+G  R L I     A  G+
Sbjct: 2175 VVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGV 2234

Query: 1243 YTC-----QSGAAPGAPSLSFTV----QVAEPP--VRVVAPEA---AQTRVRSTP----- 1283
            Y C     QS A+      ++T+     +AE    ++ VA  A   AQ RV+  P     
Sbjct: 2235 YVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVR 2294

Query: 1284 -----------GGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
                        G LE  V  S     VRW+K  + L    + +L   G  + L +    
Sbjct: 2295 PLRDKIAMEKHRGVLECQV--SRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISDVH 2352

Query: 1333 SGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA-DVT 1391
            + D   Y CDA          VEE  +  +V  L  +TV E   A F CE S P      
Sbjct: 2353 AEDEDTYTCDAGDVKTSAQFFVEEQSIT-IVRGLQDVTVMEPAPAWFECETSIPSVRPPK 2411

Query: 1392 WLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLF 1451
            WL    V+  G  V + Q G+   L LR       G V    G + +SARL V +  ++ 
Sbjct: 2412 WLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVL 2471

Query: 1452 LRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHG 1511
             R L+     E Q V L  +     A  AV+W +   PL    +  M+ +G +  L I  
Sbjct: 2472 TRPLEPKTGRELQSVVLSCDFRP--APKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILR 2529

Query: 1512 VILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE 1571
            ++ AD G Y C++    +   ++V  R++ V  PL+D   +E G A+F  ELS E    E
Sbjct: 2530 LMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVE 2589

Query: 1572 WARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTI 1631
            W+  G+ LY      I   G RH LVL  +  AD+G V  ++  +  +ARL VR  PV  
Sbjct: 2590 WSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVF 2649

Query: 1632 VRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLR-LQALGTRRLLQLRRC 1690
            ++   DL   E  T   +CE+S   A V W KDG  L PS +   L   GTR L+ +   
Sbjct: 2650 LKALDDLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLV-VHDV 2708

Query: 1691 GPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETT-- 1748
             P DAG Y+C VG+      R+ V +  V +   L+++   EG+  +FEC +S    +  
Sbjct: 2709 SPEDAGLYTCHVGSEET-RARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDP 2767

Query: 1749 GRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPL 1808
              W +GG+ +   +R +  ++G+K+ILV+ E    DAGEV F      S A L V   P 
Sbjct: 2768 AMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPA 2827

Query: 1809 QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIH 1868
             + + P  ++ V  G    L   +SR+G  V WL++   +    KY++   G    LVI 
Sbjct: 2828 AIIK-PLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIR 2886

Query: 1869 DVRPEDQGTYCCQAGQDSTHTRLLVE 1894
                +D G Y C+     +   L VE
Sbjct: 2887 GASLKDAGEYTCEVEASKSTASLHVE 2912



 Score =  497 bits (1280), Expect = e-140
 Identities = 512/1913 (26%), Positives = 781/1913 (40%), Gaps = 178/1913 (9%)

Query: 19   RPVRVVSGAEAELKCVVLG----EPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
            RP+   +G E  L+ VVL       P  V W K    L+ SE+     +G    L +   
Sbjct: 2473 RPLEPKTGRE--LQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRL 2530

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
            +P DAGVY C+A    G A+++  VTV                       E   V +TGP
Sbjct: 2531 MPADAGVYRCQA----GSAHSSTEVTV-----------------------EAREVTVTGP 2563

Query: 135  RSQWVLRGAEVV------LTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                 L+ AE         +C      E  + W  +GM L    DS H     GR     
Sbjct: 2564 -----LQDAEATEEGWASFSCELSHEDEE-VEWSLNGMPLYN--DSFHEISHKGRRH--- 2612

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
                 L + + +  D+G+     R +       A L+V   P              V  L
Sbjct: 2613 ----TLVLKSIQRADAGI----VRASSLKVSTSARLEVRVKP--------------VVFL 2650

Query: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP-DRRRLMYRDRDGGFVLKVL 307
            K          G  A  +C V   PE  + W  +G  L P D+   ++     G V+  +
Sbjct: 2651 KALDDLSAEERGTLA-LQCEV-SDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDV 2708

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS 367
                +D GLY C      G   +  ++ V +  +  T+ L+ +E  E      EC + + 
Sbjct: 2709 --SPEDAGLYTC----HVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHE 2762

Query: 368  RI--PTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
                P  W    + +    +++   +G    L++      D G  +  +RG     + + 
Sbjct: 2763 SASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIV 2822

Query: 426  VKGP--ILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRD------GEELPVICQSSSG 477
             + P  I+K L  +  V  GE+  L  E   AG    W +D       ++  V+C+   G
Sbjct: 2823 RERPAAIIKPLEDQW-VAPGEDVELRCELSRAGTPVHWLKDRKAIRKSQKYDVVCE---G 2878

Query: 478  HMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLT 537
             M  LV+ G + +DAGE T  +  S++T  L V+  + +      L  +    K T + T
Sbjct: 2879 TMAMLVIRGASLKDAGEYTCEVEASKSTASLHVE--EKANCFTEELTNLQVEEKGTAVFT 2936

Query: 538  WKPPEPAPETPFIYRL---------ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDY 588
             K   PA    +   L         +  + G    +   ++EKA +     D   ++   
Sbjct: 2937 CKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRA 2996

Query: 589  RFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT-- 646
            +  +      GR  H++                LEDV V +G  A F   +S        
Sbjct: 2997 QLLV-----QGRRVHII--------------EDLEDVDVQEGSSATFRCRISPANYEPVH 3037

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSA 706
            WFL+   L +NE         L     Q G  H L L  +  +DSG +  F     + SA
Sbjct: 3038 WFLDKTPLHANE---------LNEIDAQPGGYHVLTLRQLALKDSGTIY-FEAGDQRASA 3087

Query: 707  ALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKM 766
            AL + E P   +  ++    T T  E + L CE S  D P  W KDG+ +  S    +  
Sbjct: 3088 ALRVTEKPS--VFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSH 3145

Query: 767  DGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVM 826
            +G + +L++  A +QDSG ++C   G  +   V V   PV   +  + + V  +      
Sbjct: 3146 EGHRAQLLITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEV--LEGGAAT 3203

Query: 827  LACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
            L C +    APV+W      +   D   L  EG    LV+   +P D G + C  GD+  
Sbjct: 3204 LRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTT 3263

Query: 887  YFTVTITDVSSWIVYPSGKVY-VAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945
              T+T+T + +  +   GK+    A       L CEL +  A V W K  E + +     
Sbjct: 3264 SATLTVTALPAQFI---GKLRNKEATEGATATLRCELSKA-APVEWRKGSETLRDGDRYC 3319

Query: 946  LQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYP-RDEVTLIAVTL 1004
            L+++  +  L +  + + D+ EY C   +E  S ++T+   P   I   R + ++   T 
Sbjct: 3320 LRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQESIEGAT- 3378

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
                L CELS+  APV W K    + + +   L +DG  C L +      D GE+ C  G
Sbjct: 3379 --ATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCG 3435

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
            ++    T+TV A P +      R+ +   GA     L CE++   + V W K    +   
Sbjct: 3436 EERTSATLTVKALPAKFTE-GLRNEEAVEGATAM--LWCELSKV-APVEWRKGPENLRDG 3491

Query: 1125 DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            D   L  EG    L +      DAGEY+C    E  +  + +   P +F+          
Sbjct: 3492 DRYILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRALPARFIEDVKNQE--- 3548

Query: 1185 VAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYT 1244
               G   VL CEL+ A APV W      +++G+   L  +G +  L I+    A  G Y+
Sbjct: 3549 AREGATAVLQCELNSA-APVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYS 3607

Query: 1245 CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYK 1304
            C  G    +  L+    V   P++            +T G    L   LS    PV W+K
Sbjct: 3608 CVCGQERTSAMLT----VRALPIKFTE---GLRNEEATEGATAVLRCELSKMA-PVEWWK 3659

Query: 1305 DGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVS 1364
              E L    R  L Q GAR  L+++G  + DAGEYLC   ++    +++V   +  K + 
Sbjct: 3660 GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLTVRA-MPSKFIE 3718

Query: 1365 ELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             L      EGD AT  CE+S   A V W +    +  G +  + Q+GS   L +RG  + 
Sbjct: 3719 GLRNEEATEGDTATLWCELSKA-APVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVV 3777

Query: 1425 DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWV 1484
            DAG  +   G   TSA L VR     F+  +++  A EG    L+ E  +   A  V W 
Sbjct: 3778 DAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSK---AAPVEWR 3834

Query: 1485 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            +G + L    R S+ QDG    L IHG+ +AD G Y C    +RT A L+VR  Q     
Sbjct: 3835 KGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFRE 3894

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLA 1604
            PL+ +   EG +AT Q ELS+   T  W++GG+QL    +      G    LVL  L   
Sbjct: 3895 PLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQRE 3954

Query: 1605 DSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKD 1664
            D+G  + T  S   +A L V   PV  +R     EV EG TA   CELS+A A V W K 
Sbjct: 3955 DTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVEWRKG 4014

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
               L P  + ++   G    L +R     DAG Y+C  G  ++    L+VR       + 
Sbjct: 4015 SLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQS-MASLSVRVPRPKFKTR 4073

Query: 1725 LRSVSAREGDGATFECTVSEVETTG--RWELGGRPLRPGARVRIRQEGKKHILVLSELRA 1782
            L+S+    GD A   C +S+ E+    +W   G  L  G +  +R +G    L++ +L A
Sbjct: 4074 LQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEA 4133

Query: 1783 EDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG-HVCW 1841
            +D GE     G  ++ A L V    + + R    +  V           VSR+G   V W
Sbjct: 4134 KDTGEYACVTGGQKTAASLRVTEPEVTIVRGLV-DAEVTADEDVEFSCEVSRAGATGVQW 4192

Query: 1842 LREGAELCPGDKYEMR-SHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
              +G  L   +  E+    G  H+L +  V PED GT     G  ++  +L V
Sbjct: 4193 CLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTV 4245



 Score =  450 bits (1158), Expect = e-126
 Identities = 501/1891 (26%), Positives = 762/1891 (40%), Gaps = 174/1891 (9%)

Query: 39   PPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC---RARNAAGEAYA 95
            P   V W KG  +L AS +     +G    L ++A    D+  Y C   +A++ A     
Sbjct: 2942 PAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQ 3001

Query: 96   AAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLP 155
               V ++E      +L+  +                       V  G+     CR     
Sbjct: 3002 GRRVHIIE------DLEDVD-----------------------VQEGSSATFRCRISPAN 3032

Query: 156  EPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAH 215
               ++W  D   L         A +    +  PG    L +    L DSG     A    
Sbjct: 3033 YEPVHWFLDKTPLH--------ANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA---- 3080

Query: 216  GHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEP 275
            G  +A A L+V + P     +  +A                + EG+     C       P
Sbjct: 3081 GDQRASAALRVTEKPSVFSRELTDAT---------------ITEGEDLTLVCETSTCDIP 3125

Query: 276  EIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLH 335
             + W  +G+ L    R  +  +     +L +     +D G Y C A  +   ++  V++H
Sbjct: 3126 -VCWTKDGKTLRGSARCQLSHEGHRAQLL-ITGATLQDSGRYKCEAGGACSSSI--VRVH 3181

Query: 336  VKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVR 395
             +   +RF   L+D+E  E G A L C + +   P  W   +  L P  KY   +EG + 
Sbjct: 3182 ARP--VRFQEALKDLEVLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAML 3239

Query: 396  RLIIHRLKADDDGIYLCEMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVET 452
             L++  L+  D G Y C   G   T A +TV       + +L R  +  EG  A L  E 
Sbjct: 3240 ELVVRNLRPQDSGRYSCSF-GDQTTSATLTVTALPAQFIGKL-RNKEATEGATATLRCEL 3297

Query: 453  LEAG-VEGRWS----RDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTL 507
             +A  VE R      RDG+     C    G M  L + G+   DA E +   G  RT+  
Sbjct: 3298 SKAAPVEWRKGSETLRDGDR---YCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSAS 3354

Query: 508  LRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCF 567
            L ++ +     G     E  +G   T+       E +   P  +R  R+ +   D     
Sbjct: 3355 LTIRPMPAHFIGRLRHQESIEGATATLRC-----ELSKAAPVEWRKGRESLRDGD---RH 3406

Query: 568  SIEKAGAV---EVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLED 624
            S+ + GAV   ++ G  V   G+Y      V G  R+   +   +   +P A+   GL +
Sbjct: 3407 SLRQDGAVCELQICGLAVADAGEY----SCVCGEERTSATL---TVKALP-AKFTEGLRN 3458

Query: 625  VQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH 684
             +  +G  A+   +LS +    W    E L+  +          RY + Q+G +  L + 
Sbjct: 3459 EEAVEGATAMLWCELSKVAPVEWRKGPENLRDGD----------RYILRQEGTRCELQIC 3508

Query: 685  AVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD 744
             +   D+G  +   C   + SA LTI+  P   +  +D  +         VL CEL+   
Sbjct: 3509 GLAMADAGEYL-CVCGQERTSATLTIRALPARFI--EDVKNQEAREGATAVLQCELNSA- 3564

Query: 745  FPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDP 804
             P  W K  + + + +   ++ DG K  L +    + D+GE+ C          +TV+  
Sbjct: 3565 APVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRAL 3624

Query: 805  PVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRL 864
            P+   +   +    A      +L CE+ +  APV W+K  + + + D   L  +G    L
Sbjct: 3625 PIKFTEGLRN--EEATEGATAVLRCELSKM-APVEWWKGHETLRDGDRHSLRQDGARCEL 3681

Query: 865  VLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR 924
             +      D GE+ C+ G E     +T+  + S  +   G     A   +   L CEL +
Sbjct: 3682 QIRGLVAEDAGEYLCMCGKERTSAMLTVRAMPSKFI--EGLRNEEATEGDTATLWCELSK 3739

Query: 925  PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT 984
              A V W K  E + +     L+++ +   L +  + + D+GEY C    E  S T+TV 
Sbjct: 3740 A-APVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVR 3798

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRC 1044
              P R I   D     A      VL CELS+  APV W K    +   +   L +DG RC
Sbjct: 3799 ALPARFI--EDVKNQEAREGATAVLQCELSKA-APVEWRKGSETLRGGDRYSLRQDGTRC 3855

Query: 1045 RLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCE 1104
             L +      D GE+ C  G +    T+TV A P+ +     +SL    G+     L+CE
Sbjct: 3856 ELQIHGLSVADTGEYSCVCGQERTSATLTVRA-PQPVFREPLQSLQAEEGS--TATLQCE 3912

Query: 1105 VAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNV 1164
            ++   + V W K GL+++A+   +   +G T  L L   Q ED GEY C    +A +  +
Sbjct: 3913 LSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTCGSQATSATL 3972

Query: 1165 ILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAE 1224
             +   PV+FL          V  G    L CELSRAGA V W      +      ++  +
Sbjct: 3973 TVTAAPVRFLRELQHQE---VDEGGTAHLCCELSRAGASVEWRKGSLQLFPCAKYQMVQD 4029

Query: 1225 GPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRS--- 1281
            G    L ++      AG YTC +G      SLS         VRV  P+  +TR++S   
Sbjct: 4030 GAAAELLVRGVEQEDAGDYTCDTGHTQSMASLS---------VRVPRPK-FKTRLQSLEQ 4079

Query: 1282 TPGGDLELVVHLSG--PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEY 1339
              G    L   LS    G  V+W K+G  L +  + ++   GA + L +    + D GEY
Sbjct: 4080 ETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEY 4139

Query: 1340 LCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA-DVTWLRNGAV 1398
             C          + V EP  V +V  L    V   +D  F CEVS   A  V W   G  
Sbjct: 4140 ACVTGGQKTAASLRVTEP-EVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLP 4198

Query: 1399 VTPGPQVEMA-QNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQD 1457
            +      E+A ++G    L L+G    DAGTV+   G+ A+SA+L VR  E+  L  LQD
Sbjct: 4199 LQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAPEVTILEPLQD 4258

Query: 1458 VRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSM-AQDGHIHRLFIHGVILAD 1516
            V+  EGQD   +    R     A RW  GG PL  +    +  + G +H L +H V L D
Sbjct: 4259 VQLSEGQDASFQCRLSRASGQEA-RWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLED 4317

Query: 1517 QGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE-WARG 1575
             GT         + A+L V  +   V+R LE+V   EGG A F+ +LSQ  V    W   
Sbjct: 4318 AGTVSFHVGTCSSEAQLKVTAKN-TVVRGLENVEALEGGEALFECQLSQPEVAAHTWLLD 4376

Query: 1576 GVQLYPGPKCHI--HSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVR 1633
               ++      +    +G RH L+L  L   DS  V+F A  +  +A L VR   + I+ 
Sbjct: 4377 DEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVTSAFLTVRGWRLEILE 4436

Query: 1634 GPHDLEVTEGDTATFECELSQA--LADVTWEKDGNALTPSPR-LRLQALGTRRLLQLRRC 1690
               +  V  G  A F C LS+A  + + +W  +G A+ P      + A G+   L LR  
Sbjct: 4437 PLKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSA 4496

Query: 1691 GPSDAG--TYSC--AVGTARAGPVRL---------TVRERTVAVLSELRSVSAREGDGAT 1737
             P  AG  T++C  AV +AR   + L           R      LS    +S   G    
Sbjct: 4497 QPHHAGEVTFACRDAVASARLTVLGLPDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCG 4556

Query: 1738 FECTVSEVETTGRWELGGRPLRPGARVRI--RQEGKKHILVLSELRAEDAGEVRFQAGPA 1795
            +   V E   TG+W L    L PG    +     G+ +   ++ +    AGE        
Sbjct: 4557 YRVEVKE-GATGQWRL-CHELVPGPECVVDGLAPGETYRFRVAAVGPVGAGE---PVHLP 4611

Query: 1796 QSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYE 1855
            Q++ L E    P+      P  + V  G    LE+ V    G V W +    + PG ++E
Sbjct: 4612 QTVRLAE-PPKPVPPQPSAPESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFE 4670

Query: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQAGQDS 1886
            + S G    LVI     EDQG Y C   Q S
Sbjct: 4671 VVSQGRQQMLVIKGFTAEDQGEYHCGLAQGS 4701



 Score =  427 bits (1098), Expect = e-119
 Identities = 442/1765 (25%), Positives = 696/1765 (39%), Gaps = 127/1765 (7%)

Query: 155  PEPTLYWEKDGMAL--DEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHAR 212
            PE  + W KDG+ L   + +D  H A   G           L +      D+G+Y CH  
Sbjct: 2673 PEAHVVWRKDGVQLGPSDKYDFLHTAGTRG-----------LVVHDVSPEDAGLYTCHV- 2720

Query: 213  NAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGK 272
               G  +  A ++VH           +    + + LK    T  V EG+   F C +  +
Sbjct: 2721 ---GSEETRARVRVH-----------DLHVGITKRLK----TMEVLEGESCSFECVLSHE 2762

Query: 273  PEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAV 332
               +      G   +    R     +   ++L V      D G  V + R       S  
Sbjct: 2763 SASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLT----SKA 2818

Query: 333  QLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEG 392
             L V+E      +PL+D          L C++  +  P  W ++ + +   +KY+ + EG
Sbjct: 2819 SLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAIRKSQKYDVVCEG 2878

Query: 393  TVRRLIIHRLKADDDGIYLCEMRGRVRTVA-NVTVKGPILKRLPRKLDVLEGENAVLLVE 451
            T+  L+I      D G Y CE+     T + +V  K          L V E   AV   +
Sbjct: 2879 TMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGTAVFTCK 2938

Query: 452  TLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLL 508
            T        W +   EL    +   S  G    L +  + + D+   T  +G +++   L
Sbjct: 2939 TEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQL 2998

Query: 509  RVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP------ETPFIYRLERQEVGSED 562
             V+  +          ++ +G   T      P    P      +TP ++  E  E+ ++ 
Sbjct: 2999 LVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTP-LHANELNEIDAQP 3057

Query: 563  WIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTAR---LV 619
                    +  A++  G      GD R                   SA L  T +     
Sbjct: 3058 GGYHVLTLRQLALKDSGTIYFEAGDQR------------------ASAALRVTEKPSVFS 3099

Query: 620  AGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQ 678
              L D  + +GED     + ST  I   W  +G+ L+          G+ R ++  +G +
Sbjct: 3100 RELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLR----------GSARCQLSHEGHR 3149

Query: 679  HRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVL 736
             +L++     QDSG    + C   G   S+ + +   PV     +    L         L
Sbjct: 3150 AQLLITGATLQDSGR---YKCEAGGACSSSIVRVHARPVRF--QEALKDLEVLEGGAATL 3204

Query: 737  TCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
             C LS V  P  W      +   +   ++ +G    L++   + QDSG + C     +  
Sbjct: 3205 RCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTTS 3264

Query: 797  FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLE 856
              +TV   P   +    +    A       L CE+ +  APV W K  + + + D   L 
Sbjct: 3265 ATLTVTALPAQFIGKLRNK--EATEGATATLRCELSKA-APVEWRKGSETLRDGDRYCLR 3321

Query: 857  NEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKV-YVAAVRLER 915
             +G    L +      D  E+ CV G+E    ++TI  + +  +   G++ +  ++    
Sbjct: 3322 QDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFI---GRLRHQESIEGAT 3378

Query: 916  VVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE 975
              L CEL +  A V W K  E + +     L+++  V  L +  + + D+GEY C   +E
Sbjct: 3379 ATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEE 3437

Query: 976  SASFTVTVTEPPVRIIYP-RDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEA 1034
              S T+TV   P +     R+E  +   T    +L CELS+  APV W K    + + + 
Sbjct: 3438 RTSATLTVKALPAKFTEGLRNEEAVEGAT---AMLWCELSKV-APVEWRKGPENLRDGDR 3493

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFG 1094
             +L ++G RC L +      D GE++C  G +    T+T+ A P R +    ++ +   G
Sbjct: 3494 YILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRALPARFIEDV-KNQEAREG 3552

Query: 1095 APGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
            A     L+CE+  A + V W K    +   D   L  +G    L +      D GEY C 
Sbjct: 3553 ATA--VLQCELNSA-APVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCV 3609

Query: 1155 TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQ 1214
               E  +  + +   P++F              G   VL CELS+  APV W      ++
Sbjct: 3610 CGQERTSAMLTVRALPIKFTEGLRNEE---ATEGATAVLRCELSKM-APVEWWKGHETLR 3665

Query: 1215 EGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEA 1274
            +G+   L  +G R  L I+      AG Y C  G    +  L+    V   P + +    
Sbjct: 3666 DGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLT----VRAMPSKFIE--- 3718

Query: 1275 AQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
                  +T G    L   LS    PV W K  E L    R  L Q G+R  L+++G    
Sbjct: 3719 GLRNEEATEGDTATLWCELS-KAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVV 3777

Query: 1335 DAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLR 1394
            DAGEY C   Q+     ++V   L  + + ++      EG  A  +CE+S   A V W +
Sbjct: 3778 DAGEYSCVCGQERTSATLTVRA-LPARFIEDVKNQEAREGATAVLQCELSKA-APVEWRK 3835

Query: 1395 NGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRR 1454
                +  G +  + Q+G+   L + G  + D G  +   G   TSA L VR  + +F   
Sbjct: 3836 GSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFREP 3895

Query: 1455 LQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVIL 1514
            LQ ++AEEG    L+ E     A   V W +GG  L  + R      G    L +  +  
Sbjct: 3896 LQSLQAEEGSTATLQCELSEPTAT--VVWSKGGLQLQANGRREPRLQGCTAELVLQDLQR 3953

Query: 1515 ADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWAR 1574
             D G Y C      T A L+V    +R LR L+   + EGG+A    ELS+ G + EW +
Sbjct: 3954 EDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVEWRK 4013

Query: 1575 GGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRG 1634
            G +QL+P  K  +  DG    L++ G+   D+G  +      +  A L VR         
Sbjct: 4014 GSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVPRPKFKTR 4073

Query: 1635 PHDLEVTEGDTATFECELSQAL--ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGP 1692
               LE   GD A   C+LS A   A V W K+G  L   P+  +++ G  R L + +   
Sbjct: 4074 LQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEA 4133

Query: 1693 SDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RW 1751
             D G Y+C  G  +     L V E  V ++  L        +   F C VS    TG +W
Sbjct: 4134 KDTGEYACVTGGQKTA-ASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQW 4192

Query: 1752 ELGGRPLRPGARVRIR-QEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQM 1810
             L G PL+      +  ++G+ H L L  +  EDAG V F  G   S A L V A P   
Sbjct: 4193 CLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRA-PEVT 4251

Query: 1811 CRHPPREKTVLVGRRAVLEVTVSRSGGHVC-WLREGAELCPGDKYEMR-SHGPTHSLVIH 1868
               P ++  +  G+ A  +  +SR+ G    W   G  L   +  ++    G  H L +H
Sbjct: 4252 ILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLH 4311

Query: 1869 DVRPEDQGTYCCQAGQDSTHTRLLV 1893
             V  ED GT     G  S+  +L V
Sbjct: 4312 KVTLEDAGTVSFHVGTCSSEAQLKV 4336



 Score =  404 bits (1039), Expect = e-112
 Identities = 472/1941 (24%), Positives = 733/1941 (37%), Gaps = 180/1941 (9%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V+  +G  A L C V  +P   V W K G++L++S ++     G    L++      DAG
Sbjct: 1176 VQAEAGTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAG 1234

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
             Y C A    G    +  + + EP A   + Q     + +                    
Sbjct: 1235 EYSCEA----GGQRVSFQLHITEPKAVFAKEQLVHNEVRTEA------------------ 1272

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
             GA   L+C      +  + W KDG  L     SS   ++        G    L +  A 
Sbjct: 1273 -GASATLSCEVAQA-QTEVTWYKDGKKLSS---SSKVRIEAA------GCMRQLVVQQAG 1321

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEG 260
              D+G Y C A         G  L  H     P A        V    + A +      G
Sbjct: 1322 QADAGEYTCEA--------GGQRLSFHLDVSEPKA--------VFAKEQLAHRKVQAEAG 1365

Query: 261  KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              A   C V  + + E+ W+ +G+ L    +  M        ++    CQA D G Y C 
Sbjct: 1366 AIATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQA-DTGEYSCE 1423

Query: 321  ARNSAGQTLSAVQLHVKEPRLRFTRPL---QDVEGREHGIAVLECKVPNSRIPTAWFRED 377
            A    GQ LS   L V EP++ F +     ++V+ +      L C+V  ++    W+++ 
Sbjct: 1424 A---GGQRLS-FSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDG 1479

Query: 378  QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP---ILKRL 434
            ++L    K      G  RRL++ +      G Y CE  G  R   ++ V  P     K  
Sbjct: 1480 KKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA-GSQRLSFHLHVAEPKAVFAKEQ 1538

Query: 435  P--RKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGVTR 489
            P  R++    G +A L  E  +A  E  W +DG++L     +   + G    LV+    +
Sbjct: 1539 PASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQ 1598

Query: 490  EDAGEVTFSLGNSRTTTLL-----RVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPA 544
             DAGE +   G+ R +  L     +V   K  P    + AE       +  L+ +  +  
Sbjct: 1599 ADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGA----SATLSCEVAQAQ 1654

Query: 545  PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRS--P 602
             E  +    ++    S+  ++     +   V+  G      G+Y    C   G   S   
Sbjct: 1655 TEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQA--DAGEYS---CEAGGQRLSFRL 1709

Query: 603  HVVFHGSAHLVPT-ARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT--WFLNGEELKSNEP 659
            HV     A L P  +      E + V + ED + +  L+T    T  W  +G E++ ++ 
Sbjct: 1710 HV-----AELEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSK- 1763

Query: 660  EGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILS 719
                     R+    +G  H L +H  +  DS     +SC    +     +Q   V    
Sbjct: 1764 ---------RHETASQGDTHTLTVHGAQVLDSAI---YSCRVGAEGQDFPVQVEEVAAKF 1811

Query: 720  PQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAK 779
             +    +       V L CELS       W     ++   +   +  +G    L +   +
Sbjct: 1812 CRLLEPVCGELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLR 1871

Query: 780  VQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR 839
             +D+GE+ C +        +TV  P V          V     E     C V   D  V 
Sbjct: 1872 AEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATF-QCVVSPSDVAVV 1930

Query: 840  WYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWI 899
            W++DG  ++ S+   +   G    L +      D G+    A    +   + + +    +
Sbjct: 1931 WFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAP--V 1988

Query: 900  VYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPA 959
            ++              V L  EL RPW E+RWT++   +     + +  E    RLVL  
Sbjct: 1989 LFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHN 2048

Query: 960  VQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP 1019
            V   D G + CE  D+     +TV    VR++  R    + A       +  +LS  D  
Sbjct: 2049 VGFADRGFFGCETPDDKTQAKLTVEMRQVRLV--RGLQAVEAREQGTATMEVQLSHADVD 2106

Query: 1020 VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPE 1079
              W +DGL  ++     L   GP   L L   +PED G  V  A        + VT  P 
Sbjct: 2107 GSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTELPV 2166

Query: 1080 RIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLT 1139
                P     D+      +V L CE++     VRW KDG+E+ A   + + A+G  R+LT
Sbjct: 2167 SFSRPLQ---DVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223

Query: 1140 LPHAQPEDAGEYVCETRHEA--------------ITFNVILAEPP--VQFLALETTPSPL 1183
            +   +  D G YVC+  H+A              + +  +LAE    +QF+A        
Sbjct: 2224 IYRCEFADQGVYVCDA-HDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQ 2282

Query: 1184 CVAPGEPV-----------------VLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGP 1226
                  PV                 VL C++SRA A V W    + +Q G   EL ++G 
Sbjct: 2283 LRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPKYELVSDGL 2342

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGD 1286
             R L I          YTC +G      S  F V+  E  + +V      T +   P   
Sbjct: 2343 YRKLIISDVHAEDEDTYTCDAGDVK--TSAQFFVE--EQSITIVRGLQDVTVMEPAPAW- 2397

Query: 1287 LELVVHLSGPG-GPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAG--EYLCDA 1343
                   S P   P +W      L + G V LEQ G    L ++   S   G   +    
Sbjct: 2398 --FECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGK 2455

Query: 1344 PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGP 1403
             + S   +VS    + V L   L P T  E       C+  P    V W ++   ++P  
Sbjct: 2456 SRSSARLVVS---DIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSE 2512

Query: 1404 QVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEG 1463
            + +M+  G    L +      DAG    +AGS  +S  + V   E+     LQD  A E 
Sbjct: 2513 KFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEE 2572

Query: 1464 QDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCE 1523
                   E         V W   G PL +DS   ++  G  H L +  +  AD G     
Sbjct: 2573 GWASFSCELSHEDEE--VEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRAS 2630

Query: 1524 SHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGP 1583
            S    T ARL VR + +  L+ L+D++  E G+   Q E+S       W + GVQL P  
Sbjct: 2631 SLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGPSD 2690

Query: 1584 KCH-IHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTE 1642
            K   +H+ G R  LV++ +   D+G  +    S    AR+ V ++ V I +    +EV E
Sbjct: 2691 KYDFLHTAGTRG-LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLE 2749

Query: 1643 GDTATFECELSQALAD--VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAG--TY 1698
            G++ +FEC LS   A     W   G  +  S R +    G + +L +R   PSDAG   +
Sbjct: 2750 GESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVF 2809

Query: 1699 SCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPL 1758
            S    T++A    L VRER  A++  L       G+     C +S   T   W    + +
Sbjct: 2810 SVRGLTSKAS---LIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAI 2866

Query: 1759 RPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVE----ALPLQMCRHP 1814
            R   +  +  EG   +LV+     +DAGE   +   ++S A L VE        ++    
Sbjct: 2867 RKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQ 2926

Query: 1815 PREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPED 1874
              EK       AV           V W +   EL    K++    G T  L I  +   D
Sbjct: 2927 VEEKGT-----AVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKAD 2981

Query: 1875 QGTYCCQAGQDSTHTRLLVEG 1895
              TY C  GQ  +  +LLV+G
Sbjct: 2982 SDTYTCDIGQAQSRAQLLVQG 3002



 Score =  387 bits (993), Expect = e-107
 Identities = 356/1325 (26%), Positives = 530/1325 (40%), Gaps = 69/1325 (5%)

Query: 607  HGSAHLVPTARLVA---GLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQ 662
            H SA LV T   V+    L+DV   + E      +LS   +   W  +G EL++ +    
Sbjct: 2154 HTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAI 2213

Query: 663  VEPGALR----YRIE---------------------QKGLQHRLILHAVKHQDSGALVGF 697
               GA R    YR E                      +G  + LI   V  +D+G  + F
Sbjct: 2214 AAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGE-IQF 2272

Query: 698  SCPGVQDSAALTIQESPVHILSP-QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKV 756
                 +  A L ++E PV ++ P +D++++      R VL C++SR      W+K  Q++
Sbjct: 2273 VAENAESRAQLRVKELPVTLVRPLRDKIAME---KHRGVLECQVSRASAQVRWFKGSQEL 2329

Query: 757  EESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVF 816
            +      +  DG   +LI+ +   +D   + C    V       V++  + IV   + V 
Sbjct: 2330 QPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFFVEEQSITIVRGLQDVT 2389

Query: 817  VHAITSECVMLACEVDREDA-PVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            V  +        CE       P +W      ++    V LE EG   RL+L  T  +  G
Sbjct: 2390 V--MEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
                  G   +   + ++D+   +  P          L+ VVL+C+       V+W KD 
Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPK--TGRELQSVVLSCDFRPAPKAVQWYKDD 2505

Query: 936  EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRD 995
              +  S    +  E  +  L +  +   D+G Y C+     +S  VTV    V +  P  
Sbjct: 2506 TPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQ 2565

Query: 996  EVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPED 1055
            +    A         CELS ED  V W  +G+ +       +   G R  LVL + Q  D
Sbjct: 2566 DAE--ATEEGWASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRAD 2623

Query: 1056 GGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWY 1115
             G     +   S    + V   P  +V   A   DL     G + L+CEV+   + V W 
Sbjct: 2624 AGIVRASSLKVSTSARLEVRVKP--VVFLKALD-DLSAEERGTLALQCEVSDPEAHVVWR 2680

Query: 1116 KDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLA 1175
            KDG+++  SD         TR L +    PEDAG Y C    E     V + +  V    
Sbjct: 2681 KDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITK 2740

Query: 1176 LETTPSPLCVAPGEPVVLSCELSRAGA--PVVWSHNGRPVQEGEGLELHAEGPRRVLCIQ 1233
               T     V  GE     C LS   A  P +W+  G+ V      +   +G + +L ++
Sbjct: 2741 RLKTME---VLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVR 2797

Query: 1234 AAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
             A P+ AG             SL     V E P  ++ P   Q      PG D+EL   L
Sbjct: 2798 EAAPSDAGEVVFSVRGLTSKASLI----VRERPAAIIKPLEDQW---VAPGEDVELRCEL 2850

Query: 1294 SGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVS 1353
            S  G PV W KD + +    +  +   G   +L ++GA   DAGEY C+         + 
Sbjct: 2851 SRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLH 2910

Query: 1354 VEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSS 1413
            VEE        ELT L V E   A F C+   P A VTW +    +    + + +Q G +
Sbjct: 2911 VEEKANC-FTEELTNLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLT 2969

Query: 1414 RILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETG 1473
              LT+   +  D+ T T   G   + A+L V+   +  +  L+DV  +EG          
Sbjct: 2970 LRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRC--- 3026

Query: 1474 RVGAAG--AVRWVRGGQPLPHDSRLSM--AQDGHIHRLFIHGVILADQGTYGCESHHDRT 1529
            R+  A    V W     PL H + L+   AQ G  H L +  + L D GT   E+   R 
Sbjct: 3027 RISPANYEPVHWFLDKTPL-HANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRA 3085

Query: 1530 LARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHS 1589
             A L V  +     R L D TI+EG   T   E S   +   W + G  L    +C +  
Sbjct: 3086 SAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSH 3145

Query: 1590 DGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFE 1649
            +GHR +L++ G  L DSG     A     ++ + V   PV       DLEV EG  AT  
Sbjct: 3146 EGHRAQLLITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGAATLR 3205

Query: 1650 CELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGP 1709
            C LS   A V W    N L P  +  L+  G    L +R   P D+G YSC+ G      
Sbjct: 3206 CVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTTSA 3265

Query: 1710 VRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQE 1769
              LTV       + +LR+  A EG  AT  C +S+      W  G   LR G R  +RQ+
Sbjct: 3266 T-LTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPV-EWRKGSETLRDGDRYCLRQD 3323

Query: 1770 GKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLE 1829
            G    L +  L   DA E     G  ++ A L +  +P         ++++  G  A L 
Sbjct: 3324 GAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQESI-EGATATLR 3382

Query: 1830 VTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHT 1889
              +S++   V W +    L  GD++ +R  G    L I  +   D G Y C  G++ T  
Sbjct: 3383 CELSKAAP-VEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSA 3441

Query: 1890 RLLVE 1894
             L V+
Sbjct: 3442 TLTVK 3446



 Score =  359 bits (922), Expect = 1e-98
 Identities = 442/1753 (25%), Positives = 688/1753 (39%), Gaps = 189/1753 (10%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            P  F R      +  G +  L C       PV  W K G+ L  S R     +G    LL
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIPVC-WTKDGKTLRGSARCQLSHEGHRAQLL 3153

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +T A   D+G Y C       EA  A + +++   A     Q A + L            
Sbjct: 3154 ITGATLQDSGRYKC-------EAGGACSSSIVRVHARPVRFQEALKDLE----------- 3195

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED--GP 188
                    VL G    L C    +  P              W   +  L+PG        
Sbjct: 3196 --------VLEGGAATLRCVLSSVAAPVK------------WCYGNNVLRPGDKYSLRQE 3235

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
            GA L L +   R  DSG Y C    + G     A L V              PA  +  L
Sbjct: 3236 GAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTV-----------TALPAQFIGKL 3280

Query: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
            +    T    EG  A  RC  + K  P +EW  +G   L D  R   R +DG        
Sbjct: 3281 RNKEAT----EGATATLRCE-LSKAAP-VEWR-KGSETLRDGDRYCLR-QDGAM------ 3326

Query: 309  CQAKDRGL-YVCAARNSA--GQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
            C+ + RGL  V AA  S   G+  ++  L ++     F   L+  E  E   A L C++ 
Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELS 3386

Query: 366  NSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
             +  P  W +  + L    ++   ++G V  L I  L   D G Y C + G  RT A +T
Sbjct: 3387 KAA-PVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSC-VCGEERTSATLT 3444

Query: 426  VKGPILKRLP--RKLDVLEGENAVLLVETLE-AGVEGRWS----RDGEELPVICQSSSGH 478
            VK    K     R  + +EG  A+L  E  + A VE R      RDG+   +      G 
Sbjct: 3445 VKALPAKFTEGLRNEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYIL---RQEGT 3501

Query: 479  MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKN----TV 534
               L + G+   DAGE     G  RT+  L ++ +      P    E  K  +     T 
Sbjct: 3502 RCELQICGLAMADAGEYLCVCGQERTSATLTIRAL------PARFIEDVKNQEAREGATA 3555

Query: 535  LLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGA---VEVPGDCVPSEGDYRFR 591
            +L  +    AP     +R   + +   D    +S+ + G    +++ G  +   G+Y   
Sbjct: 3556 VLQCELNSAAPVE---WRKGSETLRDGDR---YSLRQDGTKCELQIRGLAMADTGEYS-- 3607

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
               V G  R+  ++   +   +P  +   GL + +  +G  AV   +LS +    W+   
Sbjct: 3608 --CVCGQERTSAML---TVRALPI-KFTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH 3661

Query: 652  EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
            E L+  +          R+ + Q G +  L +  +  +D+G  +   C   + SA LT++
Sbjct: 3662 ETLRDGD----------RHSLRQDGARCELQIRGLVAEDAGEYLCM-CGKERTSAMLTVR 3710

Query: 712  ESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKH 771
              P   +        T    +   L CELS+   P  W K  + + + +   ++ DG + 
Sbjct: 3711 AMPSKFIEGLRNEEAT--EGDTATLWCELSKAA-PVEWRKGHETLRDGDRHSLRQDGSRC 3767

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEV 831
             L +    V D+GE+ C          +TV+  P   ++  ++    A      +L CE+
Sbjct: 3768 ELQIRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQ--EAREGATAVLQCEL 3825

Query: 832  DREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVT 891
             +  APV W K  + +   D   L  +G    L +     +D GE+ CV G E    T+T
Sbjct: 3826 SKA-APVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLT 3884

Query: 892  ITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDT 951
            +       V+      + A       L CEL  P A V W+K G ++  +     + +  
Sbjct: 3885 VRAPQP--VFREPLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGC 3942

Query: 952  VRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRII--YPRDEVTLIAVTLECVVL 1009
               LVL  +Q ED+GEY C    ++ S T+TVT  PVR +      EV        C   
Sbjct: 3943 TAELVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLC--- 3999

Query: 1010 MCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAF 1069
             CELSR  A V W K  L++       + +DG    L++   + ED G++ CD G   + 
Sbjct: 4000 -CELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058

Query: 1070 FTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQL 1129
             +++V  P  +      +SL+   G   R+  +   A +G+ V+W K+G+E+ A    ++
Sbjct: 4059 ASLSVRVPRPKF-KTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEM 4117

Query: 1130 GAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGE 1189
             ++G TR L +   + +D GEY C T  +    ++ + EP V  +          V   E
Sbjct: 4118 RSQGATRELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVDAE---VTADE 4174

Query: 1190 PVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHA-EGPRRVLCIQAAGPAHAGLYTCQS 1247
             V  SCE+SRAGA  V W   G P+Q  E  E+   +G    L ++   P  AG  +   
Sbjct: 4175 DVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHL 4234

Query: 1248 GAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDG 1306
            G    +  L+    V  P V ++ P      V+ + G D      LS   G   RW   G
Sbjct: 4235 GNHASSAQLT----VRAPEVTILEP---LQDVQLSEGQDASFQCRLSRASGQEARWALGG 4287

Query: 1307 ERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVK--- 1361
              L +     + +EQ G   +L +      DAG           +   S E  L V    
Sbjct: 4288 VPLQANEMNDITVEQ-GTLHLLTLHKVTLEDAGTV------SFHVGTCSSEAQLKVTAKN 4340

Query: 1362 -LVSELTPLTVHEGDDATFRCEVSPPD-ADVTWLRNGAVVTPGPQVEMA--QNGSSRILT 1417
             +V  L  +   EG +A F C++S P+ A  TWL +   V      E+   +NG   +L 
Sbjct: 4341 TVVRGLENVEALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLL 4400

Query: 1418 LRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGA 1477
            L+  +  D+  VT  AG   TSA L VR   L  L  L++     G   C          
Sbjct: 4401 LKNLRPQDSCRVTFLAGDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVP 4460

Query: 1478 AGAVRW-VRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQG--TYGCE---SHHDRTLA 1531
             G   W + G    P DS  ++  DG  H L +        G  T+ C    +    T+ 
Sbjct: 4461 VGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLTVL 4520

Query: 1532 RLSVRPRQLRVL-RPLEDVTIS--------EGGSATFQLELSQEGVTGEWARGGVQLYPG 1582
             L   P    V+ R    VT+S         GG   +++E+ +EG TG+W R   +L PG
Sbjct: 4521 GLPDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEV-KEGATGQW-RLCHELVPG 4578

Query: 1583 PKCHIH--SDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEV 1640
            P+C +   + G  +R  +  +G   +G       ++R A     + VP      P   +V
Sbjct: 4579 PECVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEP--PKPVPPQ-PSAPESRQV 4635

Query: 1641 TEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
              G+  + E E+     +V W K    + P  R  + + G +++L ++     D G Y C
Sbjct: 4636 AAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHC 4695

Query: 1701 AVGTARAGPVRLT 1713
             +      P   T
Sbjct: 4696 GLAQGSICPAAAT 4708



 Score =  288 bits (737), Expect = 3e-77
 Identities = 467/1975 (23%), Positives = 741/1975 (37%), Gaps = 263/1975 (13%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            P  F    + + V+ G  A L+CV+     PV  W  G   L   ++ S   +GA   L+
Sbjct: 3184 PVRFQEALKDLEVLEGGAATLRCVLSSVAAPVK-WCYGNNVLRPGDKYSLRQEGAMLELV 3242

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +    P D+G Y C    + G+   +A +TV   PA                       F
Sbjct: 3243 VRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQ----------------------F 3276

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +   R++    GA   L C         + W K    L    D   + L+    +DG   
Sbjct: 3277 IGKLRNKEATEGATATLRCELS--KAAPVEWRKGSETLR---DGDRYCLR----QDGAMC 3327

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
             L +R LA  + D+  Y C      G  +  A L +              PA  +  L+ 
Sbjct: 3328 ELQIRGLA--MVDAAEYSCVC----GEERTSASLTIRP-----------MPAHFIGRLRH 3370

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
                    EG  A  RC  + K  P +EW  +GR  L D  R   R       L++    
Sbjct: 3371 QESI----EGATATLRCE-LSKAAP-VEWR-KGRESLRDGDRHSLRQDGAVCELQICGLA 3423

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP 370
              D G Y C      G+  ++  L VK    +FT  L++ E  E   A+L C++ +   P
Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCEL-SKVAP 3478

Query: 371  TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPI 430
              W +  + L    +Y   +EGT   L I  L   D G YLC + G+ RT A +T++   
Sbjct: 3479 VEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC-VCGQERTSATLTIRALP 3537

Query: 431  LKRLP--RKLDVLEGENAVLLVETLEAG-VEGRWS----RDGEELPVICQSSSGHMHALV 483
             + +   +  +  EG  AVL  E   A  VE R      RDG+   +      G    L 
Sbjct: 3538 ARFIEDVKNQEAREGATAVLQCELNSAAPVEWRKGSETLRDGDRYSL---RQDGTKCELQ 3594

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP 543
            + G+   D GE +   G  RT+ +L V+ +       PI  +  +G +N         E 
Sbjct: 3595 IRGLAMADTGEYSCVCGQERTSAMLTVRAL-------PI--KFTEGLRNE--------EA 3637

Query: 544  APETPFIYRLERQEVGSEDWIQCF---------SIEKAGA---VEVPGDCVPSEGDYRFR 591
                  + R E  ++   +W +           S+ + GA   +++ G      G+Y   
Sbjct: 3638 TEGATAVLRCELSKMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEY--- 3694

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
            +C + G  R+  ++   +   +P+ + + GL + +  +G+ A    +LS      W    
Sbjct: 3695 LC-MCGKERTSAML---TVRAMPS-KFIEGLRNEEATEGDTATLWCELSKAAPVEWRKGH 3749

Query: 652  EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD--SAALT 709
            E L+  +          R+ + Q G +  L +  +   D+G    +SC   Q+  SA LT
Sbjct: 3750 ETLRDGD----------RHSLRQDGSRCELQIRGLAVVDAGE---YSCVCGQERTSATLT 3796

Query: 710  IQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGR 769
            ++  P   +  +D  +         VL CELS+   P  W K  + +   +   ++ DG 
Sbjct: 3797 VRALPARFI--EDVKNQEAREGATAVLQCELSKAA-PVEWRKGSETLRGGDRYSLRQDGT 3853

Query: 770  KHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLAC 829
            +  L +    V D+GE+ C          +TV+ P     +P + +   A       L C
Sbjct: 3854 RCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFREPLQSL--QAEEGSTATLQC 3911

Query: 830  EVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFT 889
            E+    A V W K G +++ +       +G    LVL   Q  D GE+ C  G +    T
Sbjct: 3912 ELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTCGSQATSAT 3971

Query: 890  VTITDVSSWIVYPSGKVYVAAVRLERVV------------LTCELCRPWAEVRWTKDGEE 937
            +T+T               A VR  R +            L CEL R  A V W K   +
Sbjct: 3972 LTVT--------------AAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVEWRKGSLQ 4017

Query: 938  VVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEV 997
            +       + ++     L++  V+ ED+G+Y C+        T ++    VR+  P+ + 
Sbjct: 4018 LFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCD-----TGHTQSMASLSVRVPRPKFKT 4072

Query: 998  TLIAV---TLECVVLMCELSRED--APVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQ 1052
             L ++   T +   L C+LS  +  A V+W K+G+E+       +   G    L++   +
Sbjct: 4073 RLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLE 4132

Query: 1053 PEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ- 1111
             +D GE+ C  G      ++ VT P   IV      +D    A   VE  CEV+ AG+  
Sbjct: 4133 AKDTGEYACVTGGQKTAASLRVTEPEVTIVRGL---VDAEVTADEDVEFSCEVSRAGATG 4189

Query: 1112 VRWYKDGLEVEASDALQLGA-EGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPP 1170
            V+W   GL +++++  ++   +G   TL L    PEDAG       + A +  + +  P 
Sbjct: 4190 VQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAPE 4249

Query: 1171 VQFLALETTPSPLCVAPGEPVVLSCELSRA-GAPVVWSHNGRPVQEGEGLELHAE-GPRR 1228
            V  L        + ++ G+     C LSRA G    W+  G P+Q  E  ++  E G   
Sbjct: 4250 VTILE---PLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLH 4306

Query: 1229 VLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLE 1288
            +L +       AG  +   G       L  T +     VR +        V +  GG+  
Sbjct: 4307 LLTLHKVTLEDAGTVSFHVGTCSSEAQLKVTAK--NTVVRGLE------NVEALEGGEAL 4358

Query: 1289 LVVHLSGPGGPVR-WYKDGERL--ASQGRVQLEQAGARQVLRVQGARSGD-------AGE 1338
                LS P      W  D E +  +    V   + G R +L ++  R  D       AG+
Sbjct: 4359 FECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGD 4418

Query: 1339 YLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSP--PDADVTWLRNG 1396
             +  A    R + + + EPL            V  G  A F C +S   P  + +W  NG
Sbjct: 4419 MVTSAFLTVRGWRLEILEPL--------KNAAVRAGAQACFTCTLSEAVPVGEASWYING 4470

Query: 1397 AVVTPGPQV-EMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR------ETEL 1449
            A V P      +  +GS   L LR  Q   AG VT        SARL V       E   
Sbjct: 4471 AAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLTVLGLPDPPEDAE 4530

Query: 1450 LFLRRLQDVR-------AEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG 1502
            +  R    V        ++ G  +C      + GA G  R      P P      +A  G
Sbjct: 4531 VVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAP-G 4589

Query: 1503 HIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPL-EDVTISEGGSATFQL 1561
              +R  +  V     G    E  H     RL+  P+ +       E   ++ G   + +L
Sbjct: 4590 ETYRFRVAAVGPVGAG----EPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLEL 4645

Query: 1562 ELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSFTADSLRC 1618
            E+  E     W +G  ++ PG +  + S G +  LV+ G    D G   C          
Sbjct: 4646 EVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHCGLAQGSICPA 4705

Query: 1619 AARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQA 1678
            AA   V   P ++   P      E         L +ALA          L     L  + 
Sbjct: 4706 AATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMSREPTLDSISELPEED 4765

Query: 1679 LGTRRLLQ-LRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGAT 1737
              ++RL Q      P  +  YS A   AR G              ++L   S+ +   A 
Sbjct: 4766 GRSQRLPQEAEEVAPDLSEGYSTADELARTGD-------------ADLSHTSSDDESRAG 4812

Query: 1738 FECTVSEVETTGRWELG------GRPLRPGARVRIRQEGKKHILV-LSELRAEDAGE--- 1787
                V+ ++  GR          G P  P  + + +QE    +   L +L  +D G+   
Sbjct: 4813 TPSLVTYLKKAGRPGTSPLASKVGAPAAPSVKPQQQQEPLAAVRPPLGDLSTKDLGDPSM 4872

Query: 1788 ----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLE-VTVSRSGGHVCWL 1842
                V+ QA         E++     M  H   +    VG    LE V  S++     WL
Sbjct: 4873 DKAAVKIQAAFKGYKVRKEMKQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWL 4932

Query: 1843 REGAELCPGDKYEMRSHGP-THSLVIHDVRPEDQGTYCCQAGQ---DSTHTRLLV 1893
            ++G EL  G  + +   G  T SL+I  +   D G Y CQ        TH+  +V
Sbjct: 4933 KDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVV 4987



 Score =  178 bits (452), Expect = 4e-44
 Identities = 204/796 (25%), Positives = 316/796 (39%), Gaps = 94/796 (11%)

Query: 1178 TTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAG 1236
            T P    V+ G+   LSC++     P V W  + +PV  G    L  +G    L I    
Sbjct: 14   TRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLA 73

Query: 1237 PAHAGLYTCQSGAAPGAPSLSFTVQV-AEPPVRVVAPE--AAQTRVRSTPGGDLELVVHL 1293
               +G Y C++  A G    +  +QV AE      AP      T +R   G +      +
Sbjct: 74   LGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRV 133

Query: 1294 SGPGGP-VRWYKDGERLASQG--RVQLEQAGARQVLRVQGARSGDAGEYLCDA------- 1343
             G   P V W KDG RL      RV++E+ G    LR++ AR  D G Y   A       
Sbjct: 134  GGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAA 193

Query: 1344 ------------------PQDSRIFLVSVEEPLLVKLVSELTPL----------TVHEGD 1375
                              P  S   L++  +     + +E  P           TV EG 
Sbjct: 194  SAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGK 253

Query: 1376 DATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSR-ILTLRGCQLGDAGTVTLRA 1433
             A   C V+  P  +  W ++G +VT G +  + ++     +L +  C+  D G  T  A
Sbjct: 254  HARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTA 313

Query: 1434 ----GSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQP 1489
                G T +S  + VRE  + F +RLQD+   E +      E  +     A  W +    
Sbjct: 314  SNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEAA--WFKEETR 371

Query: 1490 LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH-DRTLARLSVRPRQLRVLRPLED 1548
            L   ++  + ++G   RL +  V   D   Y CE+    RT+A L+V+   LR L     
Sbjct: 372  LWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTA 431

Query: 1549 VTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC 1608
            V +  G +A F +EL+       W R   ++  G +  I ++G RH L ++   L D G 
Sbjct: 432  VRV--GDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQ 489

Query: 1609 VSFTADSLRCAARLIV---REVPVT-----IVRG-------------PHDLEVTEGDTAT 1647
            V+F A   + + +  V   R+ P+      +V+              PH       D   
Sbjct: 490  VAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYL 549

Query: 1648 FECELSQALADVTWEKDGNA-LTPSPRLRLQALGTRRLLQLRRCGPSDAGT--YSCAVGT 1704
             E    + L   TW +   A    +P L +  +      Q R    +  G   Y    GT
Sbjct: 550  VE---KKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGT 606

Query: 1705 ARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARV 1764
                P         +AV + L++V A EG   TF   ++ V + G W L G+ L+  +  
Sbjct: 607  VHLAP--------KLAVRTPLKAVQAVEGGEVTFSVDLT-VASAGEWFLDGQALKASSVY 657

Query: 1765 RIRQEGKKHILVLSELRAEDAG-EVRFQAGPAQSLALLEVEALPLQMCRHPP----REKT 1819
             I  +  +H L + E+ A   G +++F A   +S   +EV A P      PP    RE  
Sbjct: 658  EIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVL 717

Query: 1820 VLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYC 1879
              +   A L   +S     V WL++G  L PG KYE+++      L++ DV  +D G Y 
Sbjct: 718  ARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYE 777

Query: 1880 CQAGQDSTHTRLLVEG 1895
            C +       +L V+G
Sbjct: 778  CVSRGGRIAYQLSVQG 793



 Score =  115 bits (287), Expect = 5e-25
 Identities = 114/388 (29%), Positives = 155/388 (39%), Gaps = 68/388 (17%)

Query: 126 GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAE 185
           GAP FLT P++  V  G +  L+C+  G P P + WEKD      V   + F L    A+
Sbjct: 8   GAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKD---QQPVAAGARFRL----AQ 60

Query: 186 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
           DG      L IL   L DSG YVC ARNA G A A   LQV         D + A A   
Sbjct: 61  DGD--LYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQV---------DAEAACAEQA 109

Query: 246 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVL 304
                 P +  V EG  A FRC V G P P + W  +GR L  PD  R+   +      L
Sbjct: 110 PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASAL 169

Query: 305 KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV---------------------------- 336
           ++   + +D G Y   A N  G   +A  L V                            
Sbjct: 170 RIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREA 229

Query: 337 -------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRK--- 385
                    P    TR     EG+    A L C V     P T W ++ Q +   R+   
Sbjct: 230 MRAEGAPASPPSTGTRTCTVTEGKH---ARLSCYVTGEPKPETVWKKDGQLVTEGRRHVV 286

Query: 386 YEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVKGPIL--KRLPRKLDV 440
           YE  +E  V +++    K  D G+Y C    + G+  +   V V+ P +  K+  + L+V
Sbjct: 287 YEDAQENFVLKILF--CKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEV 344

Query: 441 LEGENAVLLVETLEAGVEGRWSRDGEEL 468
            E E+A  L E  +   E  W ++   L
Sbjct: 345 REKESATFLCEVPQPSTEAAWFKEETRL 372



 Score =  101 bits (252), Expect = 6e-21
 Identities = 102/352 (28%), Positives = 137/352 (38%), Gaps = 38/352 (10%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG-AEHGLL 70
            P FL   +   V  G      CVV G+P P V W K G+ L   +      D    H L+
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLI 5185

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTV------LEPPASDPE----------LQPA 114
            +TA +P D GVY C A N+ G +   A + V       +  A   E          L   
Sbjct: 5186 ITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSR 5245

Query: 115  ERPLPSPGSGEGA-PVFLTGPRSQWVLRGAEVV-LTCRAGGLPEPTLYWEKDGMALDEVW 172
            E+      + EG  P  +   R   V  G  +     +  G P P LYW KDG  L    
Sbjct: 5246 EQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTA-- 5303

Query: 173  DSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVH---QP 229
             S+H  +   +          L I++    DSG Y  +  NA G A + A L V    +P
Sbjct: 5304 -SAHIRMTDKKILH------TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEP 5356

Query: 230  PESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG--RPLL 287
             E P +D  E   P     +  PK   V +G    F   V G+P P + W  E   R +L
Sbjct: 5357 EEKPASDVHEQLVPPRMLERFTPKK--VKKGSSITFSVKVEGRPVPTVHWLREEAERGVL 5414

Query: 288  ---PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
               PD              L +L    + +G Y C A N+AGQ L +  LHV
Sbjct: 5415 WIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHV 5466



 Score = 87.8 bits (216), Expect = 9e-17
 Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 29/230 (12%)

Query: 142  GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
            G  V L CR  G P+P + W KDG A+    D  H  ++       P  S AL + +   
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQV--DPHHILIED------PDGSCALILDSLTG 6079

Query: 202  PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGK 261
             DSG Y+C A +A G+      + V  PP              V  ++ +P      EG+
Sbjct: 6080 VDSGQYMCFAASAAGNCSTLGKILVQVPPR------------FVNKVRASPFV----EGE 6123

Query: 262  HAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
             A+F C + G P P+I W+ +G  L    + + +   R G  VL +     +D GLY C 
Sbjct: 6124 DAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECE 6183

Query: 321  ARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP 370
              N  G   ++ +L ++ P L+     Q+   RE  +A +E     +++P
Sbjct: 6184 LVNRLGSARASAELRIQSPMLQ----AQEQCHREQLVAAVEVTEQETKVP 6229



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 83/279 (29%), Positives = 115/279 (41%), Gaps = 50/279 (17%)

Query: 103  EPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWE 162
            E PA  P + P   PLPS  + + APVFLT  ++Q V  G  V   C   G P P++ W 
Sbjct: 5105 ETPA--PVVPP--EPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWF 5160

Query: 163  KDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGA 222
            KDG  L+E     H+ +     ED  G    L I A    D GVY C A N+ G +   A
Sbjct: 5161 KDGKLLEE---DDHYMIN----EDQQGGH-QLIITAVVPADMGVYRCLAENSMGVSSTKA 5212

Query: 223  LLQVH---------------------------QPPESPPADPDEAPAP-VVEPLK---CA 251
             L+V                            +  E   +  DE   P VVE L+    A
Sbjct: 5213 ELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVA 5272

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            P T      + AKF+  V G P P + W  +G+PL      +   D+     L+++    
Sbjct: 5273 PGT------RLAKFQLKVKGYPAPRLYWFKDGQPLTAS-AHIRMTDKKILHTLEIISVTR 5325

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDV 350
            +D G Y     N+ G   S+ +L V+ P     +P  DV
Sbjct: 5326 EDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDV 5364



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 61/229 (26%), Positives = 92/229 (40%), Gaps = 10/229 (4%)

Query: 4    SSGDQGSPPCFLRFPRPVRVVSGAE-AELKCVVLGEPPPVVVWEKGGQQLAASERLSFPA 62
            S+ D+G  P  +   R ++V  G   A+ +  V G P P + W K GQ L AS  +    
Sbjct: 5252 STTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTD 5311

Query: 63   DGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
                H L + +    D+G Y     NA G AY++A + V  P       +P E+P     
Sbjct: 5312 KKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPD------EPEEKPASDVH 5365

Query: 123  SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPG 182
                 P  L     + V +G+ +  + +  G P PT++W ++      +W        PG
Sbjct: 5366 EQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPD---TPG 5422

Query: 183  RAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE 231
                      +L +L       G Y C A NA G A   A L V   P+
Sbjct: 5423 YTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPK 5471



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 11/181 (6%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G+  K  C V G P+P I W+ +G+ +  D   ++  D DG   L +      D G Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087

Query: 320  AARNSAG--QTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFRE 376
             A ++AG   TL  + + V    +   R    VEG +   A   C +  +  P   W+++
Sbjct: 6088 FAASAAGNCSTLGKILVQVPPRFVNKVRASPFVEGED---AQFTCTIEGAPYPQIRWYKD 6144

Query: 377  DQRLLPCRKYEQIEE--GTVRRLIIHRLKADDDGIYLCEM---RGRVRTVANVTVKGPIL 431
               L    K++ + E    +  L+I     +D G+Y CE+    G  R  A + ++ P+L
Sbjct: 6145 GALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPML 6204

Query: 432  K 432
            +
Sbjct: 6205 Q 6205



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 59/206 (28%), Positives = 81/206 (39%), Gaps = 33/206 (16%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQ--QLAASERLSFPADGAEHGLLLTAALPTDAGVYV 83
            G   +L C V G P PV+ W K G+  Q+     L    DG+   L+L +    D+G Y+
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGS-CALILDSLTGVDSGQYM 6086

Query: 84   CRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGA 143
            C A +AAG       + V  PP                        F+   R+   + G 
Sbjct: 6087 CFAASAAGNCSTLGKILVQVPPR-----------------------FVNKVRASPFVEGE 6123

Query: 144  EVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPD 203
            +   TC   G P P + W KDG  L     +    L   R+       L L I AA   D
Sbjct: 6124 DAQFTCTIEGAPYPQIRWYKDGALL--TTGNKFQTLSEPRS-----GLLVLVIRAASKED 6176

Query: 204  SGVYVCHARNAHGHAQAGALLQVHQP 229
             G+Y C   N  G A+A A L++  P
Sbjct: 6177 LGLYECELVNRLGSARASAELRIQSP 6202



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 64/217 (29%), Positives = 96/217 (44%), Gaps = 16/217 (7%)

Query: 947  QKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLEC 1006
            ++ED+VR+ +L A        ++ EI        + V  PP    +  +     A   E 
Sbjct: 5974 EREDSVRKYLLQARTAIIKSSWVKEICGIQQRLALPVWRPPD---FEEELADCTAELGET 6030

Query: 1007 VVLMCELSREDAPV-RWYKDG--LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC-- 1061
            V L C ++    PV  WYKDG  ++V+    L+ + DG  C L+L +    D G+++C  
Sbjct: 6031 VKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGS-CALILDSLTGVDSGQYMCFA 6089

Query: 1062 --DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGL 1119
               AG+ S    + V  PP R V+    S  +  G   +     E AP   Q+RWYKDG 
Sbjct: 6090 ASAAGNCSTLGKILVQVPP-RFVNKVRASPFVE-GEDAQFTCTIEGAPY-PQIRWYKDGA 6146

Query: 1120 EVEASDALQLGAEGPTRTLTL--PHAQPEDAGEYVCE 1154
             +   +  Q  +E  +  L L    A  ED G Y CE
Sbjct: 6147 LLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECE 6183



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 126/569 (22%), Positives = 182/569 (31%), Gaps = 118/569 (20%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG-AEHGLLLTAALPTDAGVYVC 84
            G    L+CVV  +      W K G +L           G     LL+T     DAG Y C
Sbjct: 4912 GDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTC 4971

Query: 85   RARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF---------LTGPR 135
            +  N  G+   +A V V            +E    S   GE    F         L   +
Sbjct: 4972 QVSNKFGQVTHSACVVV----------SGSESEAESSSGGELDDAFRRAARRLHRLFRTK 5021

Query: 136  SQWVLRGAEVVLTCRAG-GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLAL 194
            S   +   E+ L+   G   PE    W+          +  HF     R E    A  A+
Sbjct: 5022 SPAEVSDEELFLSADEGPAEPEEPADWQ-------TYREDEHFICI--RFEALTEARQAV 5072

Query: 195  RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADP-------DEAPAPVVEP 247
                      G+ V       G  +    +    P    P +P       D AP  + E 
Sbjct: 5073 TRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTE- 5131

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
                 +   V +G    F C V G+P P + W  +G+ L  D   ++  D+ GG  L + 
Sbjct: 5132 ----LQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIIT 5187

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHV-------------KEPRLRFT---------- 344
                 D G+Y C A NS G + +  +L V              E    F+          
Sbjct: 5188 AVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQ 5247

Query: 345  -------------------RPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCR 384
                               R LQ   G    +A  + KV     P   WF++ Q L    
Sbjct: 5248 EGTESTTDEGQLPQVVEELRDLQVAPGTR--LAKFQLKVKGYPAPRLYWFKDGQPLTASA 5305

Query: 385  KYEQIEEGTVRRLIIHRLKADDDG---IYLCEMRGRVRTVANVTVKGPILKRLPRKLDVL 441
                 ++  +  L I  +  +D G    Y+    G   + A + V+GP         DV 
Sbjct: 5306 HIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVH 5365

Query: 442  EGENAVLLVE-------------TLEAGVEGR------WSRD---------GEELPVICQ 473
            E      ++E             T    VEGR      W R+         G + P    
Sbjct: 5366 EQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTV 5425

Query: 474  SSSGHMHALVLPGVTREDAGEVTFSLGNS 502
            +SS   H+LVL  V R+  G  T    N+
Sbjct: 5426 ASSAQQHSLVLLDVGRQHQGTYTCIASNA 5454



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 15/179 (8%)

Query: 1284 GGDLELVVHLSGPGGPV-RWYKDGERL-ASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
            G  ++L   ++G   PV  WYKDG+ +      + +E       L +      D+G+Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087

Query: 1342 DAPQD----SRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNG 1396
             A       S +  + V+ P   + V+++      EG+DA F C +   P   + W ++G
Sbjct: 6088 FAASAAGNCSTLGKILVQVP--PRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 1397 AVVTPGPQVEMAQNGSSRILTL--RGCQLGDAG----TVTLRAGSTATSARLHVRETEL 1449
            A++T G + +      S +L L  R     D G     +  R GS   SA L ++   L
Sbjct: 6146 ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPML 6204



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 65/244 (26%), Positives = 98/244 (40%), Gaps = 20/244 (8%)

Query: 648  FLNGEELKSNEPEGQVEPGALRYRI--EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDS 705
            F N  +L S +   QVE     + +  E++    + +L A       + V   C G+Q  
Sbjct: 5947 FRNMMKLSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEIC-GIQQR 6005

Query: 706  AALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQ--KVEESELL 762
             AL +   P      ++    T    E V L C ++    P  +WYKDG+  +V+   +L
Sbjct: 6006 LALPVWRPPDF---EEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHIL 6062

Query: 763  VVKMDGRKHRLILPEAKVQDSGEFEC----RTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
            +   DG    LIL      DSG++ C         S    + VQ PP  +   R   FV 
Sbjct: 6063 IEDPDG-SCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVE 6121

Query: 819  AITSECVMLACEVDREDAP-VRWYKDGQEVEESD-FVVL-ENEGPHRRLVLPATQPSDGG 875
                E     C ++    P +RWYKDG  +   + F  L E       LV+ A    D G
Sbjct: 6122 ---GEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLG 6178

Query: 876  EFQC 879
             ++C
Sbjct: 6179 LYEC 6182



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 46/159 (28%), Positives = 69/159 (43%), Gaps = 12/159 (7%)

Query: 823  ECVMLACEVDREDAPV-RWYKDGQEVE-ESDFVVLENEGPHRRLVLPATQPSDGGEFQCV 880
            E V LAC V     PV  WYKDG+ V+ +   +++E+      L+L +    D G++ C 
Sbjct: 6029 ETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCF 6088

Query: 881  AGD---ECAYFTVTITDVSSWIVYPSGKVYVAA-VRLERVVLTCEL-CRPWAEVRWTKDG 935
            A      C+     +  V    V    KV  +  V  E    TC +   P+ ++RW KDG
Sbjct: 6089 AASAAGNCSTLGKILVQVPPRFV---NKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 936  EEVVESPAL--LLQKEDTVRRLVLPAVQLEDSGEYLCEI 972
              +        L +    +  LV+ A   ED G Y CE+
Sbjct: 6146 ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECEL 6184



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 15/163 (9%)

Query: 1188 GEPVVLSCELSRAGAPVV-WSHNGRPVQ-EGEGLELHAEGPRRVLCIQAAGPAHAGLYTC 1245
            GE V L+C ++    PV+ W  +G+ VQ +   + +        L + +     +G Y C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087

Query: 1246 QSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTP---GGDLELVVHLSGPGGP-VR 1301
             + +A G  S    + V  PP  V        +VR++P   G D +    + G   P +R
Sbjct: 6088 FAASAAGNCSTLGKILVQVPPRFV-------NKVRASPFVEGEDAQFTCTIEGAPYPQIR 6140

Query: 1302 WYKDGERLASQGRVQL--EQAGARQVLRVQGARSGDAGEYLCD 1342
            WYKDG  L +  + Q   E      VL ++ A   D G Y C+
Sbjct: 6141 WYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECE 6183



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 87/336 (25%), Positives = 116/336 (34%), Gaps = 82/336 (24%)

Query: 1639 EVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQA--LGTRRLLQLRRCGPSDA 1695
            EV +G   +F+C ++ Q +  V W KDG  L       +     G  +L+ +    P+D 
Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLI-ITAVVPADM 5194

Query: 1696 GTYSC------AVGTARA------------------------------------GPVRLT 1713
            G Y C       V + +A                                    G    T
Sbjct: 5195 GVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTT 5254

Query: 1714 VRERTVAVLSELRSVSAREGDG-ATFECTVSEVETTGR-WELGGRPLRPGARVRIRQEGK 1771
               +   V+ ELR +    G   A F+  V         W   G+PL   A +R+  +  
Sbjct: 5255 DEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKI 5314

Query: 1772 KHILVLSELRAEDAGE----VRFQAGPAQSLALL------EVEALPLQMCRH---PPR-- 1816
             H L +  +  ED+G+    +    G A S A L      E E  P         PPR  
Sbjct: 5315 LHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRML 5374

Query: 1817 ----EKTVLVGRRAVLEVTVS-RSGGHVCWLREGAEL--------CPGDKYEMRSHGPTH 1863
                 K V  G      V V  R    V WLRE AE          PG  Y + S    H
Sbjct: 5375 ERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG--YTVASSAQQH 5432

Query: 1864 SLVIHDVRPEDQGTYCC----QAGQDSTHTRLLVEG 1895
            SLV+ DV  + QGTY C     AGQ      L V G
Sbjct: 5433 SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSG 5468



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 32/97 (32%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER---LSFPADGAEH 67
            PP F+   R    V G +A+  C + G P P + W K G  L    +   LS P  G   
Sbjct: 6107 PPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL-L 6165

Query: 68   GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEP 104
             L++ AA   D G+Y C   N  G A A+A + +  P
Sbjct: 6166 VLVIRAASKEDLGLYECELVNRLGSARASAELRIQSP 6202



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 122/566 (21%), Positives = 184/566 (32%), Gaps = 135/566 (23%)

Query: 1001 AVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGP-RCRLVLPAAQPEDGGEF 1059
            A+ LECVV     S+ D   RW KDG+E+ +     +++ G   C L++      D G +
Sbjct: 4914 ALRLECVVA----SKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCY 4969

Query: 1060 VCDAGDDSAFFT----VTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWY 1115
             C   +     T    V V+         +   LD  F    R   R             
Sbjct: 4970 TCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRT--------- 5020

Query: 1116 KDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT--------FNVILA 1167
            K   EV   +      EGP         Q     E+    R EA+T        F  + A
Sbjct: 5021 KSPAEVSDEELFLSADEGPAEPEEPADWQTYREDEHFICIRFEALTEARQAVTRFQEMFA 5080

Query: 1168 ------------------------EPPVQFLALETTPSPLC---------------VAPG 1188
                                    E P   +  E  PS L                V  G
Sbjct: 5081 TLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDG 5140

Query: 1189 EPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPR-RVLCIQAAGPAHAGLYTCQ 1246
             PV   C ++    P V W  +G+ ++E +   ++ +      L I A  PA  G+Y C 
Sbjct: 5141 YPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCL 5200

Query: 1247 SGAAPGAPSLSFTVQV---------AEPPVRVVAPEAAQTRVRS---------TPGGDLE 1288
            +  + G  S    ++V         A       +  +AQ  + S         T  G L 
Sbjct: 5201 AENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLP 5260

Query: 1289 LVVH-------------------LSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRV 1328
             VV                    + G P   + W+KDG+ L +   +++        L +
Sbjct: 5261 QVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEI 5320

Query: 1329 QGARSGDAGEY-------LCDAPQDSRIFLVSVEEP------------LLVKLVSELTPL 1369
                  D+G+Y       +  A   +R+ +   +EP            +  +++   TP 
Sbjct: 5321 ISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPK 5380

Query: 1370 TVHEGDDATFRCEV-SPPDADVTWLRNGA---VVTPGPQV---EMAQNGSSRILTLRGCQ 1422
             V +G   TF  +V   P   V WLR  A   V+  GP      +A +     L L    
Sbjct: 5381 KVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVG 5440

Query: 1423 LGDAGTVTL----RAGSTATSARLHV 1444
                GT T      AG    SA LHV
Sbjct: 5441 RQHQGTYTCIASNAAGQALCSASLHV 5466



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 42/195 (21%), Positives = 78/195 (40%), Gaps = 45/195 (23%)

Query: 825  VMLACEVDREDAP-VRWYKDGQEVEESD-FVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882
            V   C V  +  P VRW+KDG+ +EE D +++ E++    +L++ A  P+D G ++C+A 
Sbjct: 5143 VSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAE 5202

Query: 883  DECAYFTV--------------TITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR---- 924
            +     +               T  D +    Y S + Y+++   E    T +  +    
Sbjct: 5203 NSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQV 5262

Query: 925  -------------------------PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPA 959
                                     P   + W KDG+ +  S  + +  +  +  L + +
Sbjct: 5263 VEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIIS 5322

Query: 960  VQLEDSGEYLCEIDD 974
            V  EDSG+Y   I +
Sbjct: 5323 VTREDSGQYAAYISN 5337



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 127/609 (20%), Positives = 209/609 (34%), Gaps = 144/609 (23%)

Query: 741  SRVDFPATWYKDGQKVEESELLVVKMDGRKHR----------LILPEAKVQDSGEFECRT 790
            S+ D  A W KDG ++          DGR H           L++      D+G + C+ 
Sbjct: 4923 SKADVRARWLKDGVELT---------DGRHHHIDQLGDGTCSLLITGLDRADAGCYTCQ- 4972

Query: 791  EGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEES 850
              VS  FG       V +V   E     +   E         R    +   K   EV + 
Sbjct: 4973 --VSNKFGQVTHSACV-VVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSDE 5029

Query: 851  DFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDE---CAYFTVTITDVSSWIVYPSGKVY 907
            +  +  +EGP         +P +  ++Q    DE   C  F   +T+             
Sbjct: 5030 ELFLSADEGP--------AEPEEPADWQTYREDEHFICIRFEA-LTEARQ---------- 5070

Query: 908  VAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGE 967
             A  R + +  T  +     E++  + G   VE   + + KE        P V  E    
Sbjct: 5071 -AVTRFQEMFATLGI---GVEIKLVEQGPRRVE---MCISKETPA-----PVVPPEPLPS 5118

Query: 968  YLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGL 1027
             L    D +  F   +    V+  YP        V+ +CVV      +    VRW+KDG 
Sbjct: 5119 LLTS--DAAPVFLTELQNQEVQDGYP--------VSFDCVVT----GQPMPSVRWFKDGK 5164

Query: 1028 EVEESEALVLERDGP-RCRLVLPAAQPEDGGEFVC------------------------- 1061
             +EE +  ++  D     +L++ A  P D G + C                         
Sbjct: 5165 LLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYD 5224

Query: 1062 ---DAGDDSAFFTV-----------TVTAPPERIVHPAARSLDLHFGAPG----RVELRC 1103
               DA + S++F+            T +   E  +      L     APG    + +L+ 
Sbjct: 5225 TAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKV 5284

Query: 1104 EVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE---YVCETRHEAI 1160
            +  PA  ++ W+KDG  + AS  +++  +    TL +     ED+G+   Y+      A 
Sbjct: 5285 KGYPA-PRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAY 5343

Query: 1161 TFNVILA-------EPPVQFLALETTP-------SPLCVAPGEPVVLSCELSRAGAPVVW 1206
            +   +L        E P   +  +  P       +P  V  G  +  S ++   G PV  
Sbjct: 5344 SSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVE--GRPVPT 5401

Query: 1207 SHNGRPVQE---------GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLS 1257
             H  R   E           G  + +   +  L +   G  H G YTC +  A G    S
Sbjct: 5402 VHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCS 5461

Query: 1258 FTVQVAEPP 1266
             ++ V+  P
Sbjct: 5462 ASLHVSGLP 5470



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 44/158 (27%), Positives = 66/158 (41%), Gaps = 12/158 (7%)

Query: 914  ERVVLTCELC-RPWAEVRWTKDGEEVVESPA-LLLQKEDTVRRLVLPAVQLEDSGEYLCE 971
            E V L C +   P   + W KDG+ V   P  +L++  D    L+L ++   DSG+Y+C 
Sbjct: 6029 ETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCF 6088

Query: 972  IDDESASFT----VTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDG 1026
                + + +    + V  PP  +   R       V  E     C +     P +RWYKDG
Sbjct: 6089 AASAAGNCSTLGKILVQVPPRFVNKVRASP---FVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 1027 --LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCD 1062
              L        + E       LV+ AA  ED G + C+
Sbjct: 6146 ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECE 6183



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 64/274 (23%), Positives = 102/274 (37%), Gaps = 57/274 (20%)

Query: 1450 LFLRRLQDVRAEEGQDVCLE-VETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHI-HRL 1507
            +FL  LQ+   ++G  V  + V TG+     +VRW + G+ L  D    + +D    H+L
Sbjct: 5127 VFLTELQNQEVQDGYPVSFDCVVTGQ--PMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184

Query: 1508 FIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEG 1567
             I  V+ AD G Y C + +      +S    +LRV     D+T ++  +A    E S   
Sbjct: 5185 IITAVVPADMGVYRCLAENS---MGVSSTKAELRV-----DLTSTDYDTAADATESSS-- 5234

Query: 1568 VTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGL-GLADSGCVSFTADSLRCAARLIVRE 1626
                              +  + G+       G     D G +    + LR         
Sbjct: 5235 ------------------YFSAQGYLSSREQEGTESTTDEGQLPQVVEELR--------- 5267

Query: 1627 VPVTIVRGPHDLEVTEGD-TATFECELSQALAD-VTWEKDGNALTPSPRLRLQALGTRRL 1684
                      DL+V  G   A F+ ++    A  + W KDG  LT S  +R+        
Sbjct: 5268 ----------DLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHT 5317

Query: 1685 LQLRRCGPSDAGTYSCAVGTARA---GPVRLTVR 1715
            L++      D+G Y+  +  A        RL VR
Sbjct: 5318 LEIISVTREDSGQYAAYISNAMGAAYSSARLLVR 5351



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 47/177 (26%), Positives = 67/177 (37%), Gaps = 31/177 (17%)

Query: 1483 WVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDR----TLARLSVRPR 1538
            W + GQPL   + + M     +H L I  V   D G Y     +      + ARL VR  
Sbjct: 5294 WFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGP 5353

Query: 1539 QLRVLRPLEDV----------------TISEGGSATFQLELSQEGV-TGEWARGGVQ--- 1578
                 +P  DV                 + +G S TF +++    V T  W R   +   
Sbjct: 5354 DEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGV 5413

Query: 1579 LYPGPKC---HIHSDGHRHRLVLNGLGLADSG---CV-SFTADSLRCAARLIVREVP 1628
            L+ GP      + S   +H LVL  +G    G   C+ S  A    C+A L V  +P
Sbjct: 5414 LWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLP 5470


>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform b [Homo sapiens]
          Length = 7968

 Score =  858 bits (2217), Expect = 0.0
 Identities = 585/1939 (30%), Positives = 896/1939 (46%), Gaps = 112/1939 (5%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P FL  P+   V  G +A L C ++G P P V WEK  Q +AA  R     DG  + L +
Sbjct: 10   PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
                  D+G YVCRARNA GEA+AA  + V      D E   AE+          AP FL
Sbjct: 70   LDLALGDSGQYVCRARNAIGEAFAAVGLQV------DAEAACAEQ----------APHFL 113

Query: 132  TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP--- 188
              P S  V  G+E    CR GG P P + W KDG  L E               DGP   
Sbjct: 114  LRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGE--------------PDGPRVR 159

Query: 189  ----GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPV 244
                G + ALRI AAR  D G Y   A N  G A A A L V        + P  + A +
Sbjct: 160  VEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAAL 219

Query: 245  V-----------------EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
            +                  P     +T  V EGKHA+  CYV G+P+PE  W  +G+ + 
Sbjct: 220  LAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVT 279

Query: 288  PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPL 347
              RR ++Y D    FVLK+L+C+  DRGLY C A N  GQT S+V + V+EP + F + L
Sbjct: 280  EGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRL 339

Query: 348  QDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDD 407
            QD+E RE   A   C+VP      AWF+E+ RL    KY   EEGT RRL +  + ADDD
Sbjct: 340  QDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDD 399

Query: 408  GIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEE 467
             +Y+CE     RTVA + V+G +L++LPRK  V  G+ A+  VE         W R+ EE
Sbjct: 400  AVYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEE 459

Query: 468  LPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILA 524
            +     +  S+ G  H L +     ED G+V F  G+ +T+T   V   +  P  PP+  
Sbjct: 460  VVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDP 519

Query: 525  EMFKGHKNTVLLTWKPPEPAPETPFI---YRLERQEVGSEDWIQCFSIEKAGAVEVPGDC 581
             +    +++V+L+W PP P  E P     Y +E++++G+  WI+C   E     E+    
Sbjct: 520  VVKARMESSVILSWSPP-PHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVAD 578

Query: 582  VPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLST 641
            V  EG+++FR+  ++  G+SP++ F G+ HL P   +   L+ VQ  +G +  FS+DL+ 
Sbjct: 579  VAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTV 638

Query: 642  IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPG 701
               G WFL+G+ LK++            Y I     +H L +  V     GA + F   G
Sbjct: 639  ASAGEWFLDGQALKASSV----------YEIHCDRTRHTLTIREVPASLHGAQLKFVANG 688

Query: 702  VQDSAALTIQESPVHILSPQDRVS---LTFTTSERVVLTCELSRVDFPATWYKDGQKVEE 758
            ++ S  + ++ +P    +     +   +     E   L  ELS      TW KDG+ +  
Sbjct: 689  IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSP 748

Query: 759  SELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
                 V+    +  L++ +    D+G +EC + G    + ++VQ     +        V 
Sbjct: 749  GPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVD 808

Query: 819  AITSECVMLACEVDREDAPVRWYKDGQEVEES-DFVVLENEGPHRRLVLPATQPSDGGEF 877
            A+        CE       V WYKDG E+  S +  + E+ G   RLV       D G +
Sbjct: 809  AVAGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTY 868

Query: 878  QCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLE---RVVLTCELCRPWAEVRWTKD 934
             C  G++   F + +++    +V+   ++    ++ E      L+CE+ +   EV W KD
Sbjct: 869  SCRVGEDSVDFRLRVSEPK--VVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKD 926

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPR 994
            G+++  S  + ++     RRLV+      D+GEY CE   +  SF + V EP  ++++ +
Sbjct: 927  GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEP--KVVFAK 984

Query: 995  DEVTLIAVTLEC---VVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAA 1051
            D+V    V  E      L CE+++    V WYKDG ++  S  + +E  G R RLV+  A
Sbjct: 985  DQVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQA 1044

Query: 1052 QPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ 1111
               D G++ C+A      F + +T P        +   ++   A     L CEVA A ++
Sbjct: 1045 GKTDAGDYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTE 1104

Query: 1112 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPV 1171
            V WYKDG ++ +S  + +  +G TR L LP A   DAGEY CE   + ++F++ + EP  
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPKG 1164

Query: 1172 QFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLC 1231
             F   ++  + +    G   +LSCE+++    V W  +G+ +     + +  +G  R L 
Sbjct: 1165 VFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLV 1224

Query: 1232 IQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVV 1291
            +Q  G A AG Y+C++    G   +SF + + EP       +     VR+  G    L  
Sbjct: 1225 VQQVGKADAGEYSCEA----GGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSC 1280

Query: 1292 HLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL 1351
             ++     V WYKDG++L+S  +V++E AG  + L VQ A   DAGEY C+A      F 
Sbjct: 1281 EVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFH 1340

Query: 1352 VSVEEPLLVKLVSELT--PLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQ 1409
            + V EP  V    +L    +    G  AT  CEV+    +VTW ++G  ++   +V M  
Sbjct: 1341 LDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEA 1400

Query: 1410 NGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRL---QDVRAEEGQDV 1466
             G +R L ++     D G  +  AG    S  L V E +++F +     ++V+A+ G   
Sbjct: 1401 VGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGAST 1460

Query: 1467 CLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH 1526
             L  E  +  A   V W + G+ L   S++ M   G   RL +     A  G Y CE+  
Sbjct: 1461 TLSCEVAQ--AQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEAGS 1518

Query: 1527 DRTLARLSV-RPRQL--RVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGP 1583
             R    L V  P+ +  +      +V    G SAT   E++Q      W + G +L    
Sbjct: 1519 QRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSS 1578

Query: 1584 KCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVR---GPHDLEV 1640
            K  + + G   RLV+   G AD+G  S  A   R +  L V E  V   +      +++ 
Sbjct: 1579 KVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQA 1638

Query: 1641 TEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
              G +AT  CE++QA  +VTW KDG  L+ S ++R++A+G  R L +++ G +DAG YSC
Sbjct: 1639 EAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC 1698

Query: 1701 AVGTARAGPVRLTVRERTVAVLS---ELRSVSAREGDGATFECTVSEVE-TTGRWELGGR 1756
              G  R    RL V E    +         +  +E +      T++     T  W   G 
Sbjct: 1699 EAGGQRLS-FRLHVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGV 1757

Query: 1757 PLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCR--HP 1814
             +R   R     +G  H L +   +  D+     + G       ++VE +  + CR   P
Sbjct: 1758 EIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEP 1817

Query: 1815 PREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPED 1874
               +   +G    L   +S +   V W     +L  G +++M + GP  SL +  +R ED
Sbjct: 1818 VCGE---LGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAED 1874

Query: 1875 QGTYCCQAGQDSTHTRLLV 1893
             G Y C++  D T  +L V
Sbjct: 1875 AGEYVCESRDDHTSAQLTV 1893



 Score =  621 bits (1602), Expect = e-177
 Identities = 473/1604 (29%), Positives = 723/1604 (45%), Gaps = 80/1604 (4%)

Query: 330  SAVQLHVKE-PRLRFTRP----LQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCR 384
            S++++ V+  P L   +P     ++V  R H  A L  ++ +      W ++ + L P  
Sbjct: 691  SSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGP 750

Query: 385  KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRK------L 438
            KYE       R L++  +  DD G+Y C  RG  R    ++V+G  L R   K      +
Sbjct: 751  KYEVQASAGRRVLLVRDVARDDAGLYECVSRGG-RIAYQLSVQG--LARFLHKDMAGSCV 807

Query: 439  DVLEGENAVLLVETLEAGVEGRWSRDGEEL----PVICQSSSGHMHALVLPGVTREDAGE 494
            D + G  A    ET EA V   W +DG EL        Q   G  H LV   VTR+D G 
Sbjct: 808  DAVAGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGT 867

Query: 495  VTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHK------NTVLLTWKPPEPAPETP 548
             +  +G       LRV     S P      E     K       +  L+ +  +   E  
Sbjct: 868  YSCRVGEDSVDFRLRV-----SEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVT 922

Query: 549  FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHG 608
            +    ++    S+  ++     +   V+  G      G+Y    C   G   S H+    
Sbjct: 923  WYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQA--DAGEYS---CEAGGQRLSFHLDVKE 977

Query: 609  SAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGA 667
                V  A+      +VQ   G  A  S +++    +  W+ +G++L S+          
Sbjct: 978  PK--VVFAKDQVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSS---------- 1025

Query: 668  LRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESPVHILSPQD-RV 724
            L+  +E KG + RL++      D+G    +SC   G + S  L I E  +     Q    
Sbjct: 1026 LKVHVEAKGCRRRLVVQQAGKTDAG---DYSCEARGQRVSFRLHITEPKMMFAKEQSVHN 1082

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
             +        +L+CE+++     TWYKDG+K+  S  + +++ G   RL+LP+A   D+G
Sbjct: 1083 EVQAEAGASAMLSCEVAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAG 1142

Query: 785  EFECRTEGVSAFFGVTVQDPP-VHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKD 843
            E+ C   G    F + + +P  V   +   H  V A      ML+CEV +    V WYKD
Sbjct: 1143 EYSCEAGGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKD 1202

Query: 844  GQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPS 903
            G+++  S  V +E +G  RRLV+     +D GE+ C AG +   F + IT+  +  V+  
Sbjct: 1203 GKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKA--VFAK 1260

Query: 904  GKVYVAAVRLER---VVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960
             ++    VR E      L+CE+ +   EV W KDG+++  S  + ++    +R+LV+   
Sbjct: 1261 EQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQA 1320

Query: 961  QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLEC---VVLMCELSRED 1017
               D+GEY CE   +  SF + V+EP  + ++ ++++    V  E      L CE+++  
Sbjct: 1321 GQADAGEYTCEAGGQRLSFHLDVSEP--KAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQ 1378

Query: 1018 APVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAP 1077
              V WYKDG ++  S  + +E  G   RLV+  A   D GE+ C+AG     F++ V  P
Sbjct: 1379 TEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEP 1438

Query: 1078 PERIV--HPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPT 1135
                    P  R +    GA     L CEVA A ++V WYKDG ++  S  +++ A G T
Sbjct: 1439 KVVFAKEQPVHREVQAQAGAS--TTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCT 1496

Query: 1136 RTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSC 1195
            R L +  A    AGEY CE   + ++F++ +AEP   F   +     +    G    LSC
Sbjct: 1497 RRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSC 1556

Query: 1196 ELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPS 1255
            E+++A   V W  +G+ +     + + A G  R L +Q AG A AG Y+C++G       
Sbjct: 1557 EVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQ----R 1612

Query: 1256 LSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRV 1315
            LSF + VAEP V     + A   V++  G    L   ++     V WYKDG++L+S  +V
Sbjct: 1613 LSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKV 1672

Query: 1316 QLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEE--PLLVKLVSELTPLTVHE 1373
            ++E  G  + L VQ A   DAGEY C+A      F + V E  P + +      PL V E
Sbjct: 1673 RVEAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISERPCRREPLVVKE 1732

Query: 1374 GDDATFRCEVSPPDA-DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
             +D      ++ P A  VTWL++G  +    + E A  G +  LT+ G Q+ D+   + R
Sbjct: 1733 HEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCR 1792

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
             G+      + V E    F R L+ V  E G  V L  E     A   V W  G   L  
Sbjct: 1793 VGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSP--ACAEVVWRCGNTQLRV 1850

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVR-PRQLRVLRPLEDVTI 1551
              R  M  +G +  L + G+   D G Y CES  D T A+L+V  PR ++ +  L  V  
Sbjct: 1851 GKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVA 1910

Query: 1552 SEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSF 1611
             EGG ATFQ  +S   V   W R G  L P  K  I   G  H L ++ L L D+G ++ 
Sbjct: 1911 EEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITV 1970

Query: 1612 TADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPS 1671
             A+    +A L VRE PV   +      V E  + T E EL++   ++ W ++  AL P 
Sbjct: 1971 EAEGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPG 2030

Query: 1672 PRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAR 1731
              + + A G R  L L   G +D G + C     +    +LTV  R V ++  L++V AR
Sbjct: 2031 KNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKT-QAKLTVEMRQVRLVRGLQAVEAR 2089

Query: 1732 EGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ 1791
            E   AT E  +S  +  G W   G   + G    +   G  H L LS LR ED+G + F+
Sbjct: 2090 EQGTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFK 2149

Query: 1792 AGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPG 1851
            A    + A L V  LP+   R P ++       +  LE  +SR    V WL++G EL  G
Sbjct: 2150 AEGVHTSARLVVTELPVSFSR-PLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAG 2208

Query: 1852 DKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
                + + G   SL I+     DQG Y C A    +   + V+G
Sbjct: 2209 KTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQG 2252



 Score =  605 bits (1561), Expect = e-172
 Identities = 483/1704 (28%), Positives = 765/1704 (44%), Gaps = 121/1704 (7%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G  A+F C    +    + W+ +G  L     R +  D      L       +D G Y C
Sbjct: 812  GGPAQFECET-SEAHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSC 870

Query: 320  AARNSAGQTLSAVQLHVKEPRLRFTRPL---QDVEGREHGIAVLECKVPNSRIPTAWFRE 376
                  G+     +L V EP++ F +     + ++      A L C+V  ++    W+++
Sbjct: 871  RV----GEDSVDFRLRVSEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKD 926

Query: 377  DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL----- 431
             ++L    K      G  RRL++ +    D G Y CE  G+ R   ++ VK P +     
Sbjct: 927  GKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQ-RLSFHLDVKEPKVVFAKD 985

Query: 432  KRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGVT 488
            +    ++    G +A L  E  +A  E  W +DG++L    +    + G    LV+    
Sbjct: 986  QVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAG 1045

Query: 489  REDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETP 548
            + DAG+ +      R +  L +         P ++    +   N V    +    A  + 
Sbjct: 1046 KTDAGDYSCEARGQRVSFRLHIT-------EPKMMFAKEQSVHNEVQA--EAGASAMLSC 1096

Query: 549  FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDC----VPSEG--DYRFRICTVSGHGRSP 602
             + + + +    +D  +  S  K G +EV G      +P  G  D     C   G   S 
Sbjct: 1097 EVAQAQTEVTWYKDGKKLSSSSKVG-MEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSF 1155

Query: 603  HVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEG 661
            H+  H +      A+  +   +VQ   G  A+ S +++    + TW+ +G++L S+    
Sbjct: 1156 HL--HITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSS--- 1210

Query: 662  QVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESPVHILS 719
                   + R+E KG   RL++  V   D+G    +SC   G + S  L I E P  + +
Sbjct: 1211 -------KVRMEVKGCTRRLVVQQVGKADAGE---YSCEAGGQRVSFQLHITE-PKAVFA 1259

Query: 720  PQDRVSLTFTTSE--RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPE 777
             +  V     T       L+CE+++     TWYKDG+K+  S  + ++  G   +L++ +
Sbjct: 1260 KEQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQ 1319

Query: 778  AKVQDSGEFECRTEGVSAFFGVTVQDPP-VHIVDPREHVFVHAITSECVMLACEVDREDA 836
            A   D+GE+ C   G    F + V +P  V   +   H  V A       L+CEV +   
Sbjct: 1320 AGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQT 1379

Query: 837  PVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVS 896
             V WYKDG+++  S  V +E  G  RRLV+     +D GE+ C AG +   F++ + +  
Sbjct: 1380 EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPK 1439

Query: 897  SWIVYPSGKVYVAAVRLER---VVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVR 953
              +V+   +     V+ +      L+CE+ +   EV W KDG+++  S  + ++     R
Sbjct: 1440 --VVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTR 1497

Query: 954  RLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLEC---VVLM 1010
            RLV+       +GEY CE   +  SF + V EP  + ++ +++     V  E      L 
Sbjct: 1498 RLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEP--KAVFAKEQPASREVQAEAGTSATLS 1555

Query: 1011 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 1070
            CE+++    V WYKDG ++  S  + +E  G   RLV+  A   D GE+ C AGD    F
Sbjct: 1556 CEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSF 1615

Query: 1071 TVTVTAPPERIV--HPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQ 1128
             + V  P        PA R +    GA     L CEVA A ++V WYKDG ++ +S  ++
Sbjct: 1616 HLHVAEPKVVFAKEQPAHREVQAEAGASAT--LSCEVAQAQTEVTWYKDGKKLSSSSKVR 1673

Query: 1129 LGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPG 1188
            + A G TR L +  A   DAGEY CE   + ++F + +AE   Q         PL V   
Sbjct: 1674 VEAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISERPCRREPLVVKEH 1733

Query: 1189 EPVVLSCELSR-AGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
            E ++L+  L+  + A V W  +G  ++  +  E  ++G    L +  A    + +Y+C+ 
Sbjct: 1734 EDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRV 1793

Query: 1248 GAAPGAPSLSFTVQVAEPPV---RVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYK 1304
            GA        F VQV E      R++ P   +       GG + L   LS     V W  
Sbjct: 1794 GAE----GQDFPVQVEEVAAKFCRLLEPVCGEL------GGTVTLACELSPACAEVVWRC 1843

Query: 1305 DGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVS 1364
               +L    R Q+   G  + L V G R+ DAGEY+C++  D     ++V  P +VK +S
Sbjct: 1844 GNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMS 1903

Query: 1365 ELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             L+ +   EG +ATF+C VSP D  V W R+GA++ P  +  ++Q+G+S  LT+    L 
Sbjct: 1904 GLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLE 1963

Query: 1425 DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWV 1484
            DAG +T+ A   ++SA L VRE  +LF ++L+    EE   V LEVE  R      +RW 
Sbjct: 1964 DAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPE--LRWT 2021

Query: 1485 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            R    L     + +  +G  HRL +H V  AD+G +GCE+  D+T A+L+V  RQ+R++R
Sbjct: 2022 RNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVR 2081

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLA 1604
             L+ V   E G+AT +++LS   V G W R G++   GP CH+   G  H L L+GL   
Sbjct: 2082 GLQAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPE 2141

Query: 1605 DSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKD 1664
            DSG + F A+ +  +ARL+V E+PV+  R   D+  TE +  T ECELS+   DV W KD
Sbjct: 2142 DSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKD 2201

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR------------------ 1706
            G  L     + + A G  R L + RC  +D G Y C    A+                  
Sbjct: 2202 GVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRR 2261

Query: 1707 -----AGPV-----------RLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGR 1750
                 AG +           +L V+E  V ++  LR   A E      EC VS      R
Sbjct: 2262 VLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVR 2321

Query: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQM 1810
            W  G + L+PG +  +  +G    L++S++ AED       AG  ++ A   VE   + +
Sbjct: 2322 WFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFFVEEQSITI 2381

Query: 1811 CRHPPREKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHD 1869
             R   ++ TV+    A  E   S  S     WL     L  G    +   G  H L++  
Sbjct: 2382 VR-GLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRR 2440

Query: 1870 VRPEDQGTYCCQAGQDSTHTRLLV 1893
                  G      G+  +  RL+V
Sbjct: 2441 TCSTMTGPVHFTVGKSRSSARLVV 2464



 Score =  499 bits (1284), Expect = e-140
 Identities = 511/1946 (26%), Positives = 789/1946 (40%), Gaps = 189/1946 (9%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V+  +GA A L C V  +    V W K G++L++S ++     G    L+L  A   DAG
Sbjct: 1084 VQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAG 1142

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
             Y C A    G    +  + + EP     + Q     + +                    
Sbjct: 1143 EYSCEA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQAEA------------------ 1180

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
             G   +L+C     P+  + W KDG  L     SS   ++        G +  L +    
Sbjct: 1181 -GTTAMLSCEVAQ-PQTEVTWYKDGKKLSS---SSKVRMEV------KGCTRRLVVQQVG 1229

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEG 260
              D+G Y C A    G  +    L + +P              V    +          G
Sbjct: 1230 KADAGEYSCEA----GGQRVSFQLHITEPKA------------VFAKEQLVHNEVRTEAG 1273

Query: 261  KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA--KDRGLYV 318
              A   C V  + + E+ W+ +G+ L    +    R    G + +++  QA   D G Y 
Sbjct: 1274 ASATLSCEV-AQAQTEVTWYKDGKKLSSSSK---VRIEAAGCMRQLVVQQAGQADAGEYT 1329

Query: 319  CAARNSAGQTLSAVQLHVKEPRLRFTRPL---QDVEGREHGIAVLECKVPNSRIPTAWFR 375
            C A    GQ LS   L V EP+  F +     + V+     IA L C+V  ++    W++
Sbjct: 1330 CEA---GGQRLS-FHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYK 1385

Query: 376  EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP---ILK 432
            + ++L    K      G  RRL++ +    D G Y CE  G+ R   ++ V  P     K
Sbjct: 1386 DGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQ-RLSFSLDVAEPKVVFAK 1444

Query: 433  RLP--RKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGV 487
              P  R++    G +  L  E  +A  E  W +DG++L     +   + G    LV+   
Sbjct: 1445 EQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQA 1504

Query: 488  TREDAGEVTFSLGNSRTTTLLRV---KCV--KHSPPGPPILAEMFKGHKNTVLLTWKPPE 542
             +  AGE +   G+ R +  L V   K V  K  P    + AE       +  L+ +  +
Sbjct: 1505 GQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEA----GTSATLSCEVAQ 1560

Query: 543  PAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSE-----GDYRFRICTVSG 597
               E  +    ++    S+  ++     +   V+  G     E     GD R        
Sbjct: 1561 AQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHL--- 1617

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKS 656
            H   P VVF         A+      +VQ   G  A  S +++    + TW+ +G++L S
Sbjct: 1618 HVAEPKVVF---------AKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSS 1668

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESP 714
            +           + R+E  G   RL++      D+G    +SC   G + S  L + E  
Sbjct: 1669 SS----------KVRVEAVGCTRRLVVQQAGQADAGE---YSCEAGGQRLSFRLHVAELE 1715

Query: 715  VHILS-PQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHR 772
              I   P  R  L     E ++LT  L+       TW KDG ++  S+       G  H 
Sbjct: 1716 PQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHT 1775

Query: 773  LILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSEC------VM 826
            L +  A+V DS  + CR        G   QD PV + +     F   +   C      V 
Sbjct: 1776 LTVHGAQVLDSAIYSCRV-------GAEGQDFPVQVEEVAAK-FCRLLEPVCGELGGTVT 1827

Query: 827  LACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
            LACE+    A V W     ++       +  EGP R L +   +  D GE+ C + D+  
Sbjct: 1828 LACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHT 1887

Query: 887  YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLL 946
               +T++ V   + + SG   V A         C +      V W +DG  +  S    +
Sbjct: 1888 SAQLTVS-VPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAI 1946

Query: 947  QKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPV---RIIYPRDEVTLIAVT 1003
             +      L +  + LED+G+   E +  S+S  + V E PV   + + P+      +VT
Sbjct: 1947 SQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVEERSSVT 2006

Query: 1004 LECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
            LE      EL+R    +RW ++   +   + + +  +G R RLVL      D G F C+ 
Sbjct: 2007 LEV-----ELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCET 2061

Query: 1064 GDDSAFFTVTVTAPPERIVHPAARSLD-LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVE 1122
             DD     +TV     R+V    R L  +     G   +  +++ A     W +DGL  +
Sbjct: 2062 PDDKTQAKLTVEMRQVRLV----RGLQAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQ 2117

Query: 1123 ASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
                  L   GP  TLTL   +PED+G  V +      +  +++ E PV F         
Sbjct: 2118 QGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTELPVSF---SRPLQD 2174

Query: 1183 LCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGL 1242
            +     E V L CELSR    V W  +G  ++ G+ + + A+G  R L I     A  G+
Sbjct: 2175 VVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGV 2234

Query: 1243 YTC-----QSGAAPGAPSLSFTV----QVAEPP--VRVVAPEA---AQTRVRSTP----- 1283
            Y C     QS A+      ++T+     +AE    ++ VA  A   AQ RV+  P     
Sbjct: 2235 YVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVR 2294

Query: 1284 -----------GGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
                        G LE  V  S     VRW+K  + L    + +L   G  + L +    
Sbjct: 2295 PLRDKIAMEKHRGVLECQV--SRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISDVH 2352

Query: 1333 SGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA-DVT 1391
            + D   Y CDA          VEE  +  +V  L  +TV E   A F CE S P      
Sbjct: 2353 AEDEDTYTCDAGDVKTSAQFFVEEQSIT-IVRGLQDVTVMEPAPAWFECETSIPSVRPPK 2411

Query: 1392 WLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLF 1451
            WL    V+  G  V + Q G+   L LR       G V    G + +SARL V +  ++ 
Sbjct: 2412 WLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVL 2471

Query: 1452 LRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHG 1511
             R L+     E Q V L  +     A  AV+W +   PL    +  M+ +G +  L I  
Sbjct: 2472 TRPLEPKTGRELQSVVLSCDFRP--APKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILR 2529

Query: 1512 VILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE 1571
            ++ AD G Y C++    +   ++V  R++ V  PL+D   +E G A+F  ELS E    E
Sbjct: 2530 LMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVE 2589

Query: 1572 WARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTI 1631
            W+  G+ LY      I   G RH LVL  +  AD+G V  ++  +  +ARL VR  PV  
Sbjct: 2590 WSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVF 2649

Query: 1632 VRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLR-LQALGTRRLLQLRRC 1690
            ++   DL   E  T   +CE+S   A V W KDG  L PS +   L   GTR L+ +   
Sbjct: 2650 LKALDDLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLV-VHDV 2708

Query: 1691 GPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETT-- 1748
             P DAG Y+C VG+      R+ V +  V +   L+++   EG+  +FEC +S    +  
Sbjct: 2709 SPEDAGLYTCHVGSEET-RARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDP 2767

Query: 1749 GRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPL 1808
              W +GG+ +   +R +  ++G+K+ILV+ E    DAGEV F      S A L V   P 
Sbjct: 2768 AMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPA 2827

Query: 1809 QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIH 1868
             + + P  ++ V  G    L   +SR+G  V WL++   +    KY++   G    LVI 
Sbjct: 2828 AIIK-PLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIR 2886

Query: 1869 DVRPEDQGTYCCQAGQDSTHTRLLVE 1894
                +D G Y C+     +   L VE
Sbjct: 2887 GASLKDAGEYTCEVEASKSTASLHVE 2912



 Score =  497 bits (1280), Expect = e-140
 Identities = 512/1913 (26%), Positives = 781/1913 (40%), Gaps = 178/1913 (9%)

Query: 19   RPVRVVSGAEAELKCVVLG----EPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
            RP+   +G E  L+ VVL       P  V W K    L+ SE+     +G    L +   
Sbjct: 2473 RPLEPKTGRE--LQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRL 2530

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
            +P DAGVY C+A    G A+++  VTV                       E   V +TGP
Sbjct: 2531 MPADAGVYRCQA----GSAHSSTEVTV-----------------------EAREVTVTGP 2563

Query: 135  RSQWVLRGAEVV------LTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                 L+ AE         +C      E  + W  +GM L    DS H     GR     
Sbjct: 2564 -----LQDAEATEEGWASFSCELSHEDEE-VEWSLNGMPLYN--DSFHEISHKGRRH--- 2612

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
                 L + + +  D+G+     R +       A L+V   P              V  L
Sbjct: 2613 ----TLVLKSIQRADAGI----VRASSLKVSTSARLEVRVKP--------------VVFL 2650

Query: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP-DRRRLMYRDRDGGFVLKVL 307
            K          G  A  +C V   PE  + W  +G  L P D+   ++     G V+  +
Sbjct: 2651 KALDDLSAEERGTLA-LQCEV-SDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDV 2708

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS 367
                +D GLY C      G   +  ++ V +  +  T+ L+ +E  E      EC + + 
Sbjct: 2709 --SPEDAGLYTC----HVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHE 2762

Query: 368  RI--PTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
                P  W    + +    +++   +G    L++      D G  +  +RG     + + 
Sbjct: 2763 SASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIV 2822

Query: 426  VKGP--ILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRD------GEELPVICQSSSG 477
             + P  I+K L  +  V  GE+  L  E   AG    W +D       ++  V+C+   G
Sbjct: 2823 RERPAAIIKPLEDQW-VAPGEDVELRCELSRAGTPVHWLKDRKAIRKSQKYDVVCE---G 2878

Query: 478  HMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLT 537
             M  LV+ G + +DAGE T  +  S++T  L V+  + +      L  +    K T + T
Sbjct: 2879 TMAMLVIRGASLKDAGEYTCEVEASKSTASLHVE--EKANCFTEELTNLQVEEKGTAVFT 2936

Query: 538  WKPPEPAPETPFIYRL---------ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDY 588
             K   PA    +   L         +  + G    +   ++EKA +     D   ++   
Sbjct: 2937 CKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRA 2996

Query: 589  RFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT-- 646
            +  +      GR  H++                LEDV V +G  A F   +S        
Sbjct: 2997 QLLV-----QGRRVHII--------------EDLEDVDVQEGSSATFRCRISPANYEPVH 3037

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSA 706
            WFL+   L +NE         L     Q G  H L L  +  +DSG +  F     + SA
Sbjct: 3038 WFLDKTPLHANE---------LNEIDAQPGGYHVLTLRQLALKDSGTIY-FEAGDQRASA 3087

Query: 707  ALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKM 766
            AL + E P   +  ++    T T  E + L CE S  D P  W KDG+ +  S    +  
Sbjct: 3088 ALRVTEKPS--VFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSH 3145

Query: 767  DGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVM 826
            +G + +L++  A +QDSG ++C   G  +   V V   PV   +  + + V  +      
Sbjct: 3146 EGHRAQLLITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEV--LEGGAAT 3203

Query: 827  LACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
            L C +    APV+W      +   D   L  EG    LV+   +P D G + C  GD+  
Sbjct: 3204 LRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTT 3263

Query: 887  YFTVTITDVSSWIVYPSGKVY-VAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945
              T+T+T + +  +   GK+    A       L CEL +  A V W K  E + +     
Sbjct: 3264 SATLTVTALPAQFI---GKLRNKEATEGATATLRCELSKA-APVEWRKGSETLRDGDRYC 3319

Query: 946  LQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYP-RDEVTLIAVTL 1004
            L+++  +  L +  + + D+ EY C   +E  S ++T+   P   I   R + ++   T 
Sbjct: 3320 LRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQESIEGAT- 3378

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
                L CELS+  APV W K    + + +   L +DG  C L +      D GE+ C  G
Sbjct: 3379 --ATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCG 3435

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
            ++    T+TV A P +      R+ +   GA     L CE++   + V W K    +   
Sbjct: 3436 EERTSATLTVKALPAKFTE-GLRNEEAVEGATAM--LWCELSKV-APVEWRKGPENLRDG 3491

Query: 1125 DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            D   L  EG    L +      DAGEY+C    E  +  + +   P +F+          
Sbjct: 3492 DRYILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRALPARFIEDVKNQE--- 3548

Query: 1185 VAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYT 1244
               G   VL CEL+ A APV W      +++G+   L  +G +  L I+    A  G Y+
Sbjct: 3549 AREGATAVLQCELNSA-APVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYS 3607

Query: 1245 CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYK 1304
            C  G    +  L+    V   P++            +T G    L   LS    PV W+K
Sbjct: 3608 CVCGQERTSAMLT----VRALPIKFTE---GLRNEEATEGATAVLRCELSKMA-PVEWWK 3659

Query: 1305 DGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVS 1364
              E L    R  L Q GAR  L+++G  + DAGEYLC   ++    +++V   +  K + 
Sbjct: 3660 GHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLTVRA-MPSKFIE 3718

Query: 1365 ELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             L      EGD AT  CE+S   A V W +    +  G +  + Q+GS   L +RG  + 
Sbjct: 3719 GLRNEEATEGDTATLWCELSKA-APVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVV 3777

Query: 1425 DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWV 1484
            DAG  +   G   TSA L VR     F+  +++  A EG    L+ E  +   A  V W 
Sbjct: 3778 DAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSK---AAPVEWR 3834

Query: 1485 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            +G + L    R S+ QDG    L IHG+ +AD G Y C    +RT A L+VR  Q     
Sbjct: 3835 KGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFRE 3894

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLA 1604
            PL+ +   EG +AT Q ELS+   T  W++GG+QL    +      G    LVL  L   
Sbjct: 3895 PLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQRE 3954

Query: 1605 DSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKD 1664
            D+G  + T  S   +A L V   PV  +R     EV EG TA   CELS+A A V W K 
Sbjct: 3955 DTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVEWRKG 4014

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
               L P  + ++   G    L +R     DAG Y+C  G  ++    L+VR       + 
Sbjct: 4015 SLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQS-MASLSVRVPRPKFKTR 4073

Query: 1725 LRSVSAREGDGATFECTVSEVETTG--RWELGGRPLRPGARVRIRQEGKKHILVLSELRA 1782
            L+S+    GD A   C +S+ E+    +W   G  L  G +  +R +G    L++ +L A
Sbjct: 4074 LQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEA 4133

Query: 1783 EDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG-HVCW 1841
            +D GE     G  ++ A L V    + + R    +  V           VSR+G   V W
Sbjct: 4134 KDTGEYACVTGGQKTAASLRVTEPEVTIVRGLV-DAEVTADEDVEFSCEVSRAGATGVQW 4192

Query: 1842 LREGAELCPGDKYEMR-SHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
              +G  L   +  E+    G  H+L +  V PED GT     G  ++  +L V
Sbjct: 4193 CLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTV 4245



 Score =  450 bits (1158), Expect = e-126
 Identities = 501/1891 (26%), Positives = 762/1891 (40%), Gaps = 174/1891 (9%)

Query: 39   PPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC---RARNAAGEAYA 95
            P   V W KG  +L AS +     +G    L ++A    D+  Y C   +A++ A     
Sbjct: 2942 PAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQ 3001

Query: 96   AAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLP 155
               V ++E      +L+  +                       V  G+     CR     
Sbjct: 3002 GRRVHIIE------DLEDVD-----------------------VQEGSSATFRCRISPAN 3032

Query: 156  EPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAH 215
               ++W  D   L         A +    +  PG    L +    L DSG     A    
Sbjct: 3033 YEPVHWFLDKTPLH--------ANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEA---- 3080

Query: 216  GHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEP 275
            G  +A A L+V + P     +  +A                + EG+     C       P
Sbjct: 3081 GDQRASAALRVTEKPSVFSRELTDAT---------------ITEGEDLTLVCETSTCDIP 3125

Query: 276  EIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLH 335
             + W  +G+ L    R  +  +     +L +     +D G Y C A  +   ++  V++H
Sbjct: 3126 -VCWTKDGKTLRGSARCQLSHEGHRAQLL-ITGATLQDSGRYKCEAGGACSSSI--VRVH 3181

Query: 336  VKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVR 395
             +   +RF   L+D+E  E G A L C + +   P  W   +  L P  KY   +EG + 
Sbjct: 3182 ARP--VRFQEALKDLEVLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAML 3239

Query: 396  RLIIHRLKADDDGIYLCEMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVET 452
             L++  L+  D G Y C   G   T A +TV       + +L R  +  EG  A L  E 
Sbjct: 3240 ELVVRNLRPQDSGRYSCSF-GDQTTSATLTVTALPAQFIGKL-RNKEATEGATATLRCEL 3297

Query: 453  LEAG-VEGRWS----RDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTL 507
             +A  VE R      RDG+     C    G M  L + G+   DA E +   G  RT+  
Sbjct: 3298 SKAAPVEWRKGSETLRDGDR---YCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSAS 3354

Query: 508  LRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCF 567
            L ++ +     G     E  +G   T+       E +   P  +R  R+ +   D     
Sbjct: 3355 LTIRPMPAHFIGRLRHQESIEGATATLRC-----ELSKAAPVEWRKGRESLRDGD---RH 3406

Query: 568  SIEKAGAV---EVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLED 624
            S+ + GAV   ++ G  V   G+Y      V G  R+   +   +   +P A+   GL +
Sbjct: 3407 SLRQDGAVCELQICGLAVADAGEY----SCVCGEERTSATL---TVKALP-AKFTEGLRN 3458

Query: 625  VQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH 684
             +  +G  A+   +LS +    W    E L+  +          RY + Q+G +  L + 
Sbjct: 3459 EEAVEGATAMLWCELSKVAPVEWRKGPENLRDGD----------RYILRQEGTRCELQIC 3508

Query: 685  AVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD 744
             +   D+G  +   C   + SA LTI+  P   +  +D  +         VL CEL+   
Sbjct: 3509 GLAMADAGEYL-CVCGQERTSATLTIRALPARFI--EDVKNQEAREGATAVLQCELNSA- 3564

Query: 745  FPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDP 804
             P  W K  + + + +   ++ DG K  L +    + D+GE+ C          +TV+  
Sbjct: 3565 APVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRAL 3624

Query: 805  PVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRL 864
            P+   +   +    A      +L CE+ +  APV W+K  + + + D   L  +G    L
Sbjct: 3625 PIKFTEGLRN--EEATEGATAVLRCELSKM-APVEWWKGHETLRDGDRHSLRQDGARCEL 3681

Query: 865  VLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR 924
             +      D GE+ C+ G E     +T+  + S  +   G     A   +   L CEL +
Sbjct: 3682 QIRGLVAEDAGEYLCMCGKERTSAMLTVRAMPSKFI--EGLRNEEATEGDTATLWCELSK 3739

Query: 925  PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT 984
              A V W K  E + +     L+++ +   L +  + + D+GEY C    E  S T+TV 
Sbjct: 3740 A-APVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVR 3798

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRC 1044
              P R I   D     A      VL CELS+  APV W K    +   +   L +DG RC
Sbjct: 3799 ALPARFI--EDVKNQEAREGATAVLQCELSKA-APVEWRKGSETLRGGDRYSLRQDGTRC 3855

Query: 1045 RLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCE 1104
             L +      D GE+ C  G +    T+TV A P+ +     +SL    G+     L+CE
Sbjct: 3856 ELQIHGLSVADTGEYSCVCGQERTSATLTVRA-PQPVFREPLQSLQAEEGS--TATLQCE 3912

Query: 1105 VAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNV 1164
            ++   + V W K GL+++A+   +   +G T  L L   Q ED GEY C    +A +  +
Sbjct: 3913 LSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTCGSQATSATL 3972

Query: 1165 ILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAE 1224
             +   PV+FL          V  G    L CELSRAGA V W      +      ++  +
Sbjct: 3973 TVTAAPVRFLRELQHQE---VDEGGTAHLCCELSRAGASVEWRKGSLQLFPCAKYQMVQD 4029

Query: 1225 GPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRS--- 1281
            G    L ++      AG YTC +G      SLS         VRV  P+  +TR++S   
Sbjct: 4030 GAAAELLVRGVEQEDAGDYTCDTGHTQSMASLS---------VRVPRPK-FKTRLQSLEQ 4079

Query: 1282 TPGGDLELVVHLSG--PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEY 1339
              G    L   LS    G  V+W K+G  L +  + ++   GA + L +    + D GEY
Sbjct: 4080 ETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEY 4139

Query: 1340 LCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA-DVTWLRNGAV 1398
             C          + V EP  V +V  L    V   +D  F CEVS   A  V W   G  
Sbjct: 4140 ACVTGGQKTAASLRVTEP-EVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLP 4198

Query: 1399 VTPGPQVEMA-QNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQD 1457
            +      E+A ++G    L L+G    DAGTV+   G+ A+SA+L VR  E+  L  LQD
Sbjct: 4199 LQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAPEVTILEPLQD 4258

Query: 1458 VRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSM-AQDGHIHRLFIHGVILAD 1516
            V+  EGQD   +    R     A RW  GG PL  +    +  + G +H L +H V L D
Sbjct: 4259 VQLSEGQDASFQCRLSRASGQEA-RWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLED 4317

Query: 1517 QGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE-WARG 1575
             GT         + A+L V  +   V+R LE+V   EGG A F+ +LSQ  V    W   
Sbjct: 4318 AGTVSFHVGTCSSEAQLKVTAKN-TVVRGLENVEALEGGEALFECQLSQPEVAAHTWLLD 4376

Query: 1576 GVQLYPGPKCHI--HSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVR 1633
               ++      +    +G RH L+L  L   DS  V+F A  +  +A L VR   + I+ 
Sbjct: 4377 DEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVTSAFLTVRGWRLEILE 4436

Query: 1634 GPHDLEVTEGDTATFECELSQA--LADVTWEKDGNALTPSPR-LRLQALGTRRLLQLRRC 1690
               +  V  G  A F C LS+A  + + +W  +G A+ P      + A G+   L LR  
Sbjct: 4437 PLKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSA 4496

Query: 1691 GPSDAG--TYSC--AVGTARAGPVRL---------TVRERTVAVLSELRSVSAREGDGAT 1737
             P  AG  T++C  AV +AR   + L           R      LS    +S   G    
Sbjct: 4497 QPHHAGEVTFACRDAVASARLTVLGLPDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCG 4556

Query: 1738 FECTVSEVETTGRWELGGRPLRPGARVRI--RQEGKKHILVLSELRAEDAGEVRFQAGPA 1795
            +   V E   TG+W L    L PG    +     G+ +   ++ +    AGE        
Sbjct: 4557 YRVEVKE-GATGQWRL-CHELVPGPECVVDGLAPGETYRFRVAAVGPVGAGE---PVHLP 4611

Query: 1796 QSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYE 1855
            Q++ L E    P+      P  + V  G    LE+ V    G V W +    + PG ++E
Sbjct: 4612 QTVRLAE-PPKPVPPQPSAPESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFE 4670

Query: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQAGQDS 1886
            + S G    LVI     EDQG Y C   Q S
Sbjct: 4671 VVSQGRQQMLVIKGFTAEDQGEYHCGLAQGS 4701



 Score =  427 bits (1098), Expect = e-119
 Identities = 442/1765 (25%), Positives = 696/1765 (39%), Gaps = 127/1765 (7%)

Query: 155  PEPTLYWEKDGMAL--DEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHAR 212
            PE  + W KDG+ L   + +D  H A   G           L +      D+G+Y CH  
Sbjct: 2673 PEAHVVWRKDGVQLGPSDKYDFLHTAGTRG-----------LVVHDVSPEDAGLYTCHV- 2720

Query: 213  NAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGK 272
               G  +  A ++VH           +    + + LK    T  V EG+   F C +  +
Sbjct: 2721 ---GSEETRARVRVH-----------DLHVGITKRLK----TMEVLEGESCSFECVLSHE 2762

Query: 273  PEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAV 332
               +      G   +    R     +   ++L V      D G  V + R       S  
Sbjct: 2763 SASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLT----SKA 2818

Query: 333  QLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEG 392
             L V+E      +PL+D          L C++  +  P  W ++ + +   +KY+ + EG
Sbjct: 2819 SLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAIRKSQKYDVVCEG 2878

Query: 393  TVRRLIIHRLKADDDGIYLCEMRGRVRTVA-NVTVKGPILKRLPRKLDVLEGENAVLLVE 451
            T+  L+I      D G Y CE+     T + +V  K          L V E   AV   +
Sbjct: 2879 TMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQVEEKGTAVFTCK 2938

Query: 452  TLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLL 508
            T        W +   EL    +   S  G    L +  + + D+   T  +G +++   L
Sbjct: 2939 TEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQL 2998

Query: 509  RVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP------ETPFIYRLERQEVGSED 562
             V+  +          ++ +G   T      P    P      +TP ++  E  E+ ++ 
Sbjct: 2999 LVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTP-LHANELNEIDAQP 3057

Query: 563  WIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTAR---LV 619
                    +  A++  G      GD R                   SA L  T +     
Sbjct: 3058 GGYHVLTLRQLALKDSGTIYFEAGDQR------------------ASAALRVTEKPSVFS 3099

Query: 620  AGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQ 678
              L D  + +GED     + ST  I   W  +G+ L+          G+ R ++  +G +
Sbjct: 3100 RELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLR----------GSARCQLSHEGHR 3149

Query: 679  HRLILHAVKHQDSGALVGFSCP--GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVL 736
             +L++     QDSG    + C   G   S+ + +   PV     +    L         L
Sbjct: 3150 AQLLITGATLQDSGR---YKCEAGGACSSSIVRVHARPVRF--QEALKDLEVLEGGAATL 3204

Query: 737  TCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
             C LS V  P  W      +   +   ++ +G    L++   + QDSG + C     +  
Sbjct: 3205 RCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTTS 3264

Query: 797  FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLE 856
              +TV   P   +    +    A       L CE+ +  APV W K  + + + D   L 
Sbjct: 3265 ATLTVTALPAQFIGKLRNK--EATEGATATLRCELSKA-APVEWRKGSETLRDGDRYCLR 3321

Query: 857  NEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKV-YVAAVRLER 915
             +G    L +      D  E+ CV G+E    ++TI  + +  +   G++ +  ++    
Sbjct: 3322 QDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFI---GRLRHQESIEGAT 3378

Query: 916  VVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE 975
              L CEL +  A V W K  E + +     L+++  V  L +  + + D+GEY C   +E
Sbjct: 3379 ATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEE 3437

Query: 976  SASFTVTVTEPPVRIIYP-RDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEA 1034
              S T+TV   P +     R+E  +   T    +L CELS+  APV W K    + + + 
Sbjct: 3438 RTSATLTVKALPAKFTEGLRNEEAVEGAT---AMLWCELSKV-APVEWRKGPENLRDGDR 3493

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFG 1094
             +L ++G RC L +      D GE++C  G +    T+T+ A P R +    ++ +   G
Sbjct: 3494 YILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRALPARFIEDV-KNQEAREG 3552

Query: 1095 APGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
            A     L+CE+  A + V W K    +   D   L  +G    L +      D GEY C 
Sbjct: 3553 ATA--VLQCELNSA-APVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCV 3609

Query: 1155 TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQ 1214
               E  +  + +   P++F              G   VL CELS+  APV W      ++
Sbjct: 3610 CGQERTSAMLTVRALPIKFTEGLRNEE---ATEGATAVLRCELSKM-APVEWWKGHETLR 3665

Query: 1215 EGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEA 1274
            +G+   L  +G R  L I+      AG Y C  G    +  L+    V   P + +    
Sbjct: 3666 DGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLT----VRAMPSKFIE--- 3718

Query: 1275 AQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
                  +T G    L   LS    PV W K  E L    R  L Q G+R  L+++G    
Sbjct: 3719 GLRNEEATEGDTATLWCELS-KAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVV 3777

Query: 1335 DAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLR 1394
            DAGEY C   Q+     ++V   L  + + ++      EG  A  +CE+S   A V W +
Sbjct: 3778 DAGEYSCVCGQERTSATLTVRA-LPARFIEDVKNQEAREGATAVLQCELSKA-APVEWRK 3835

Query: 1395 NGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRR 1454
                +  G +  + Q+G+   L + G  + D G  +   G   TSA L VR  + +F   
Sbjct: 3836 GSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFREP 3895

Query: 1455 LQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVIL 1514
            LQ ++AEEG    L+ E     A   V W +GG  L  + R      G    L +  +  
Sbjct: 3896 LQSLQAEEGSTATLQCELSEPTAT--VVWSKGGLQLQANGRREPRLQGCTAELVLQDLQR 3953

Query: 1515 ADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWAR 1574
             D G Y C      T A L+V    +R LR L+   + EGG+A    ELS+ G + EW +
Sbjct: 3954 EDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVEWRK 4013

Query: 1575 GGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRG 1634
            G +QL+P  K  +  DG    L++ G+   D+G  +      +  A L VR         
Sbjct: 4014 GSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVPRPKFKTR 4073

Query: 1635 PHDLEVTEGDTATFECELSQAL--ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGP 1692
               LE   GD A   C+LS A   A V W K+G  L   P+  +++ G  R L + +   
Sbjct: 4074 LQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEA 4133

Query: 1693 SDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RW 1751
             D G Y+C  G  +     L V E  V ++  L        +   F C VS    TG +W
Sbjct: 4134 KDTGEYACVTGGQKTA-ASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQW 4192

Query: 1752 ELGGRPLRPGARVRIR-QEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQM 1810
             L G PL+      +  ++G+ H L L  +  EDAG V F  G   S A L V A P   
Sbjct: 4193 CLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRA-PEVT 4251

Query: 1811 CRHPPREKTVLVGRRAVLEVTVSRSGGHVC-WLREGAELCPGDKYEMR-SHGPTHSLVIH 1868
               P ++  +  G+ A  +  +SR+ G    W   G  L   +  ++    G  H L +H
Sbjct: 4252 ILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLH 4311

Query: 1869 DVRPEDQGTYCCQAGQDSTHTRLLV 1893
             V  ED GT     G  S+  +L V
Sbjct: 4312 KVTLEDAGTVSFHVGTCSSEAQLKV 4336



 Score =  404 bits (1039), Expect = e-112
 Identities = 472/1941 (24%), Positives = 733/1941 (37%), Gaps = 180/1941 (9%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V+  +G  A L C V  +P   V W K G++L++S ++     G    L++      DAG
Sbjct: 1176 VQAEAGTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAG 1234

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
             Y C A    G    +  + + EP A   + Q     + +                    
Sbjct: 1235 EYSCEA----GGQRVSFQLHITEPKAVFAKEQLVHNEVRTEA------------------ 1272

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
             GA   L+C      +  + W KDG  L     SS   ++        G    L +  A 
Sbjct: 1273 -GASATLSCEVAQA-QTEVTWYKDGKKLSS---SSKVRIEAA------GCMRQLVVQQAG 1321

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEG 260
              D+G Y C A         G  L  H     P A        V    + A +      G
Sbjct: 1322 QADAGEYTCEA--------GGQRLSFHLDVSEPKA--------VFAKEQLAHRKVQAEAG 1365

Query: 261  KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              A   C V  + + E+ W+ +G+ L    +  M        ++    CQA D G Y C 
Sbjct: 1366 AIATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQA-DTGEYSCE 1423

Query: 321  ARNSAGQTLSAVQLHVKEPRLRFTRPL---QDVEGREHGIAVLECKVPNSRIPTAWFRED 377
            A    GQ LS   L V EP++ F +     ++V+ +      L C+V  ++    W+++ 
Sbjct: 1424 A---GGQRLS-FSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDG 1479

Query: 378  QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP---ILKRL 434
            ++L    K      G  RRL++ +      G Y CE  G  R   ++ V  P     K  
Sbjct: 1480 KKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA-GSQRLSFHLHVAEPKAVFAKEQ 1538

Query: 435  P--RKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGVTR 489
            P  R++    G +A L  E  +A  E  W +DG++L     +   + G    LV+    +
Sbjct: 1539 PASREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQ 1598

Query: 490  EDAGEVTFSLGNSRTTTLL-----RVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPA 544
             DAGE +   G+ R +  L     +V   K  P    + AE       +  L+ +  +  
Sbjct: 1599 ADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGA----SATLSCEVAQAQ 1654

Query: 545  PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRS--P 602
             E  +    ++    S+  ++     +   V+  G      G+Y    C   G   S   
Sbjct: 1655 TEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQA--DAGEYS---CEAGGQRLSFRL 1709

Query: 603  HVVFHGSAHLVPT-ARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT--WFLNGEELKSNEP 659
            HV     A L P  +      E + V + ED + +  L+T    T  W  +G E++ ++ 
Sbjct: 1710 HV-----AELEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSK- 1763

Query: 660  EGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILS 719
                     R+    +G  H L +H  +  DS     +SC    +     +Q   V    
Sbjct: 1764 ---------RHETASQGDTHTLTVHGAQVLDSAI---YSCRVGAEGQDFPVQVEEVAAKF 1811

Query: 720  PQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAK 779
             +    +       V L CELS       W     ++   +   +  +G    L +   +
Sbjct: 1812 CRLLEPVCGELGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLR 1871

Query: 780  VQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR 839
             +D+GE+ C +        +TV  P V          V     E     C V   D  V 
Sbjct: 1872 AEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATF-QCVVSPSDVAVV 1930

Query: 840  WYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWI 899
            W++DG  ++ S+   +   G    L +      D G+    A    +   + + +    +
Sbjct: 1931 WFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAP--V 1988

Query: 900  VYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPA 959
            ++              V L  EL RPW E+RWT++   +     + +  E    RLVL  
Sbjct: 1989 LFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHN 2048

Query: 960  VQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP 1019
            V   D G + CE  D+     +TV    VR++  R    + A       +  +LS  D  
Sbjct: 2049 VGFADRGFFGCETPDDKTQAKLTVEMRQVRLV--RGLQAVEAREQGTATMEVQLSHADVD 2106

Query: 1020 VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPE 1079
              W +DGL  ++     L   GP   L L   +PED G  V  A        + VT  P 
Sbjct: 2107 GSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTELPV 2166

Query: 1080 RIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLT 1139
                P     D+      +V L CE++     VRW KDG+E+ A   + + A+G  R+LT
Sbjct: 2167 SFSRPLQ---DVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223

Query: 1140 LPHAQPEDAGEYVCETRHEA--------------ITFNVILAEPP--VQFLALETTPSPL 1183
            +   +  D G YVC+  H+A              + +  +LAE    +QF+A        
Sbjct: 2224 IYRCEFADQGVYVCDA-HDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQ 2282

Query: 1184 CVAPGEPV-----------------VLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGP 1226
                  PV                 VL C++SRA A V W    + +Q G   EL ++G 
Sbjct: 2283 LRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVRWFKGSQELQPGPKYELVSDGL 2342

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGD 1286
             R L I          YTC +G      S  F V+  E  + +V      T +   P   
Sbjct: 2343 YRKLIISDVHAEDEDTYTCDAGDVK--TSAQFFVE--EQSITIVRGLQDVTVMEPAPAW- 2397

Query: 1287 LELVVHLSGPG-GPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAG--EYLCDA 1343
                   S P   P +W      L + G V LEQ G    L ++   S   G   +    
Sbjct: 2398 --FECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGK 2455

Query: 1344 PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGP 1403
             + S   +VS    + V L   L P T  E       C+  P    V W ++   ++P  
Sbjct: 2456 SRSSARLVVS---DIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSE 2512

Query: 1404 QVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEG 1463
            + +M+  G    L +      DAG    +AGS  +S  + V   E+     LQD  A E 
Sbjct: 2513 KFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEE 2572

Query: 1464 QDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCE 1523
                   E         V W   G PL +DS   ++  G  H L +  +  AD G     
Sbjct: 2573 GWASFSCELSHEDEE--VEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRAS 2630

Query: 1524 SHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGP 1583
            S    T ARL VR + +  L+ L+D++  E G+   Q E+S       W + GVQL P  
Sbjct: 2631 SLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGPSD 2690

Query: 1584 KCH-IHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTE 1642
            K   +H+ G R  LV++ +   D+G  +    S    AR+ V ++ V I +    +EV E
Sbjct: 2691 KYDFLHTAGTRG-LVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLE 2749

Query: 1643 GDTATFECELSQALAD--VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAG--TY 1698
            G++ +FEC LS   A     W   G  +  S R +    G + +L +R   PSDAG   +
Sbjct: 2750 GESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVF 2809

Query: 1699 SCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPL 1758
            S    T++A    L VRER  A++  L       G+     C +S   T   W    + +
Sbjct: 2810 SVRGLTSKAS---LIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAI 2866

Query: 1759 RPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVE----ALPLQMCRHP 1814
            R   +  +  EG   +LV+     +DAGE   +   ++S A L VE        ++    
Sbjct: 2867 RKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTNLQ 2926

Query: 1815 PREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPED 1874
              EK       AV           V W +   EL    K++    G T  L I  +   D
Sbjct: 2927 VEEKGT-----AVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKAD 2981

Query: 1875 QGTYCCQAGQDSTHTRLLVEG 1895
              TY C  GQ  +  +LLV+G
Sbjct: 2982 SDTYTCDIGQAQSRAQLLVQG 3002



 Score =  387 bits (993), Expect = e-107
 Identities = 356/1325 (26%), Positives = 530/1325 (40%), Gaps = 69/1325 (5%)

Query: 607  HGSAHLVPTARLVA---GLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQ 662
            H SA LV T   V+    L+DV   + E      +LS   +   W  +G EL++ +    
Sbjct: 2154 HTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAI 2213

Query: 663  VEPGALR----YRIE---------------------QKGLQHRLILHAVKHQDSGALVGF 697
               GA R    YR E                      +G  + LI   V  +D+G  + F
Sbjct: 2214 AAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGE-IQF 2272

Query: 698  SCPGVQDSAALTIQESPVHILSP-QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKV 756
                 +  A L ++E PV ++ P +D++++      R VL C++SR      W+K  Q++
Sbjct: 2273 VAENAESRAQLRVKELPVTLVRPLRDKIAME---KHRGVLECQVSRASAQVRWFKGSQEL 2329

Query: 757  EESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVF 816
            +      +  DG   +LI+ +   +D   + C    V       V++  + IV   + V 
Sbjct: 2330 QPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFFVEEQSITIVRGLQDVT 2389

Query: 817  VHAITSECVMLACEVDREDA-PVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            V  +        CE       P +W      ++    V LE EG   RL+L  T  +  G
Sbjct: 2390 V--MEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTG 2447

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
                  G   +   + ++D+   +  P          L+ VVL+C+       V+W KD 
Sbjct: 2448 PVHFTVGKSRSSARLVVSDIPVVLTRPLEPK--TGRELQSVVLSCDFRPAPKAVQWYKDD 2505

Query: 936  EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRD 995
              +  S    +  E  +  L +  +   D+G Y C+     +S  VTV    V +  P  
Sbjct: 2506 TPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQ 2565

Query: 996  EVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPED 1055
            +    A         CELS ED  V W  +G+ +       +   G R  LVL + Q  D
Sbjct: 2566 DAE--ATEEGWASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRAD 2623

Query: 1056 GGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWY 1115
             G     +   S    + V   P  +V   A   DL     G + L+CEV+   + V W 
Sbjct: 2624 AGIVRASSLKVSTSARLEVRVKP--VVFLKALD-DLSAEERGTLALQCEVSDPEAHVVWR 2680

Query: 1116 KDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLA 1175
            KDG+++  SD         TR L +    PEDAG Y C    E     V + +  V    
Sbjct: 2681 KDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITK 2740

Query: 1176 LETTPSPLCVAPGEPVVLSCELSRAGA--PVVWSHNGRPVQEGEGLELHAEGPRRVLCIQ 1233
               T     V  GE     C LS   A  P +W+  G+ V      +   +G + +L ++
Sbjct: 2741 RLKTME---VLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVR 2797

Query: 1234 AAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
             A P+ AG             SL     V E P  ++ P   Q      PG D+EL   L
Sbjct: 2798 EAAPSDAGEVVFSVRGLTSKASLI----VRERPAAIIKPLEDQW---VAPGEDVELRCEL 2850

Query: 1294 SGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVS 1353
            S  G PV W KD + +    +  +   G   +L ++GA   DAGEY C+         + 
Sbjct: 2851 SRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLH 2910

Query: 1354 VEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSS 1413
            VEE        ELT L V E   A F C+   P A VTW +    +    + + +Q G +
Sbjct: 2911 VEEKANC-FTEELTNLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLT 2969

Query: 1414 RILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETG 1473
              LT+   +  D+ T T   G   + A+L V+   +  +  L+DV  +EG          
Sbjct: 2970 LRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRC--- 3026

Query: 1474 RVGAAG--AVRWVRGGQPLPHDSRLSM--AQDGHIHRLFIHGVILADQGTYGCESHHDRT 1529
            R+  A    V W     PL H + L+   AQ G  H L +  + L D GT   E+   R 
Sbjct: 3027 RISPANYEPVHWFLDKTPL-HANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRA 3085

Query: 1530 LARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHS 1589
             A L V  +     R L D TI+EG   T   E S   +   W + G  L    +C +  
Sbjct: 3086 SAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSH 3145

Query: 1590 DGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFE 1649
            +GHR +L++ G  L DSG     A     ++ + V   PV       DLEV EG  AT  
Sbjct: 3146 EGHRAQLLITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGAATLR 3205

Query: 1650 CELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGP 1709
            C LS   A V W    N L P  +  L+  G    L +R   P D+G YSC+ G      
Sbjct: 3206 CVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTTSA 3265

Query: 1710 VRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQE 1769
              LTV       + +LR+  A EG  AT  C +S+      W  G   LR G R  +RQ+
Sbjct: 3266 T-LTVTALPAQFIGKLRNKEATEGATATLRCELSKAAPV-EWRKGSETLRDGDRYCLRQD 3323

Query: 1770 GKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLE 1829
            G    L +  L   DA E     G  ++ A L +  +P         ++++  G  A L 
Sbjct: 3324 GAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQESI-EGATATLR 3382

Query: 1830 VTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHT 1889
              +S++   V W +    L  GD++ +R  G    L I  +   D G Y C  G++ T  
Sbjct: 3383 CELSKAAP-VEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSA 3441

Query: 1890 RLLVE 1894
             L V+
Sbjct: 3442 TLTVK 3446



 Score =  359 bits (922), Expect = 1e-98
 Identities = 442/1753 (25%), Positives = 688/1753 (39%), Gaps = 189/1753 (10%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            P  F R      +  G +  L C       PV  W K G+ L  S R     +G    LL
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIPVC-WTKDGKTLRGSARCQLSHEGHRAQLL 3153

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +T A   D+G Y C       EA  A + +++   A     Q A + L            
Sbjct: 3154 ITGATLQDSGRYKC-------EAGGACSSSIVRVHARPVRFQEALKDLE----------- 3195

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED--GP 188
                    VL G    L C    +  P              W   +  L+PG        
Sbjct: 3196 --------VLEGGAATLRCVLSSVAAPVK------------WCYGNNVLRPGDKYSLRQE 3235

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
            GA L L +   R  DSG Y C    + G     A L V              PA  +  L
Sbjct: 3236 GAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTV-----------TALPAQFIGKL 3280

Query: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
            +    T    EG  A  RC  + K  P +EW  +G   L D  R   R +DG        
Sbjct: 3281 RNKEAT----EGATATLRCE-LSKAAP-VEWR-KGSETLRDGDRYCLR-QDGAM------ 3326

Query: 309  CQAKDRGL-YVCAARNSA--GQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
            C+ + RGL  V AA  S   G+  ++  L ++     F   L+  E  E   A L C++ 
Sbjct: 3327 CELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHFIGRLRHQESIEGATATLRCELS 3386

Query: 366  NSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
             +  P  W +  + L    ++   ++G V  L I  L   D G Y C + G  RT A +T
Sbjct: 3387 KAA-PVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSC-VCGEERTSATLT 3444

Query: 426  VKGPILKRLP--RKLDVLEGENAVLLVETLE-AGVEGRWS----RDGEELPVICQSSSGH 478
            VK    K     R  + +EG  A+L  E  + A VE R      RDG+   +      G 
Sbjct: 3445 VKALPAKFTEGLRNEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYIL---RQEGT 3501

Query: 479  MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKN----TV 534
               L + G+   DAGE     G  RT+  L ++ +      P    E  K  +     T 
Sbjct: 3502 RCELQICGLAMADAGEYLCVCGQERTSATLTIRAL------PARFIEDVKNQEAREGATA 3555

Query: 535  LLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGA---VEVPGDCVPSEGDYRFR 591
            +L  +    AP     +R   + +   D    +S+ + G    +++ G  +   G+Y   
Sbjct: 3556 VLQCELNSAAPVE---WRKGSETLRDGDR---YSLRQDGTKCELQIRGLAMADTGEYS-- 3607

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
               V G  R+  ++   +   +P  +   GL + +  +G  AV   +LS +    W+   
Sbjct: 3608 --CVCGQERTSAML---TVRALPI-KFTEGLRNEEATEGATAVLRCELSKMAPVEWWKGH 3661

Query: 652  EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
            E L+  +          R+ + Q G +  L +  +  +D+G  +   C   + SA LT++
Sbjct: 3662 ETLRDGD----------RHSLRQDGARCELQIRGLVAEDAGEYLCM-CGKERTSAMLTVR 3710

Query: 712  ESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKH 771
              P   +        T    +   L CELS+   P  W K  + + + +   ++ DG + 
Sbjct: 3711 AMPSKFIEGLRNEEAT--EGDTATLWCELSKAA-PVEWRKGHETLRDGDRHSLRQDGSRC 3767

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEV 831
             L +    V D+GE+ C          +TV+  P   ++  ++    A      +L CE+
Sbjct: 3768 ELQIRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQ--EAREGATAVLQCEL 3825

Query: 832  DREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVT 891
             +  APV W K  + +   D   L  +G    L +     +D GE+ CV G E    T+T
Sbjct: 3826 SKA-APVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLT 3884

Query: 892  ITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDT 951
            +       V+      + A       L CEL  P A V W+K G ++  +     + +  
Sbjct: 3885 VRAPQP--VFREPLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGC 3942

Query: 952  VRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRII--YPRDEVTLIAVTLECVVL 1009
               LVL  +Q ED+GEY C    ++ S T+TVT  PVR +      EV        C   
Sbjct: 3943 TAELVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLC--- 3999

Query: 1010 MCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAF 1069
             CELSR  A V W K  L++       + +DG    L++   + ED G++ CD G   + 
Sbjct: 4000 -CELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSM 4058

Query: 1070 FTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQL 1129
             +++V  P  +      +SL+   G   R+  +   A +G+ V+W K+G+E+ A    ++
Sbjct: 4059 ASLSVRVPRPKF-KTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEM 4117

Query: 1130 GAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGE 1189
             ++G TR L +   + +D GEY C T  +    ++ + EP V  +          V   E
Sbjct: 4118 RSQGATRELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVDAE---VTADE 4174

Query: 1190 PVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHA-EGPRRVLCIQAAGPAHAGLYTCQS 1247
             V  SCE+SRAGA  V W   G P+Q  E  E+   +G    L ++   P  AG  +   
Sbjct: 4175 DVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHL 4234

Query: 1248 GAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDG 1306
            G    +  L+    V  P V ++ P      V+ + G D      LS   G   RW   G
Sbjct: 4235 GNHASSAQLT----VRAPEVTILEP---LQDVQLSEGQDASFQCRLSRASGQEARWALGG 4287

Query: 1307 ERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVK--- 1361
              L +     + +EQ G   +L +      DAG           +   S E  L V    
Sbjct: 4288 VPLQANEMNDITVEQ-GTLHLLTLHKVTLEDAGTV------SFHVGTCSSEAQLKVTAKN 4340

Query: 1362 -LVSELTPLTVHEGDDATFRCEVSPPD-ADVTWLRNGAVVTPGPQVEMA--QNGSSRILT 1417
             +V  L  +   EG +A F C++S P+ A  TWL +   V      E+   +NG   +L 
Sbjct: 4341 TVVRGLENVEALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLL 4400

Query: 1418 LRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGA 1477
            L+  +  D+  VT  AG   TSA L VR   L  L  L++     G   C          
Sbjct: 4401 LKNLRPQDSCRVTFLAGDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVP 4460

Query: 1478 AGAVRW-VRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQG--TYGCE---SHHDRTLA 1531
             G   W + G    P DS  ++  DG  H L +        G  T+ C    +    T+ 
Sbjct: 4461 VGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLTVL 4520

Query: 1532 RLSVRPRQLRVL-RPLEDVTIS--------EGGSATFQLELSQEGVTGEWARGGVQLYPG 1582
             L   P    V+ R    VT+S         GG   +++E+ +EG TG+W R   +L PG
Sbjct: 4521 GLPDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEV-KEGATGQW-RLCHELVPG 4578

Query: 1583 PKCHIH--SDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEV 1640
            P+C +   + G  +R  +  +G   +G       ++R A     + VP      P   +V
Sbjct: 4579 PECVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEP--PKPVPPQ-PSAPESRQV 4635

Query: 1641 TEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
              G+  + E E+     +V W K    + P  R  + + G +++L ++     D G Y C
Sbjct: 4636 AAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHC 4695

Query: 1701 AVGTARAGPVRLT 1713
             +      P   T
Sbjct: 4696 GLAQGSICPAAAT 4708



 Score =  288 bits (737), Expect = 3e-77
 Identities = 467/1975 (23%), Positives = 741/1975 (37%), Gaps = 263/1975 (13%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            P  F    + + V+ G  A L+CV+     PV  W  G   L   ++ S   +GA   L+
Sbjct: 3184 PVRFQEALKDLEVLEGGAATLRCVLSSVAAPVK-WCYGNNVLRPGDKYSLRQEGAMLELV 3242

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +    P D+G Y C    + G+   +A +TV   PA                       F
Sbjct: 3243 VRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQ----------------------F 3276

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +   R++    GA   L C         + W K    L    D   + L+    +DG   
Sbjct: 3277 IGKLRNKEATEGATATLRCELS--KAAPVEWRKGSETLR---DGDRYCLR----QDGAMC 3327

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
             L +R LA  + D+  Y C      G  +  A L +              PA  +  L+ 
Sbjct: 3328 ELQIRGLA--MVDAAEYSCVC----GEERTSASLTIRP-----------MPAHFIGRLRH 3370

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
                    EG  A  RC  + K  P +EW  +GR  L D  R   R       L++    
Sbjct: 3371 QESI----EGATATLRCE-LSKAAP-VEWR-KGRESLRDGDRHSLRQDGAVCELQICGLA 3423

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP 370
              D G Y C      G+  ++  L VK    +FT  L++ E  E   A+L C++ +   P
Sbjct: 3424 VADAGEYSCVC----GEERTSATLTVKALPAKFTEGLRNEEAVEGATAMLWCEL-SKVAP 3478

Query: 371  TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPI 430
              W +  + L    +Y   +EGT   L I  L   D G YLC + G+ RT A +T++   
Sbjct: 3479 VEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC-VCGQERTSATLTIRALP 3537

Query: 431  LKRLP--RKLDVLEGENAVLLVETLEAG-VEGRWS----RDGEELPVICQSSSGHMHALV 483
             + +   +  +  EG  AVL  E   A  VE R      RDG+   +      G    L 
Sbjct: 3538 ARFIEDVKNQEAREGATAVLQCELNSAAPVEWRKGSETLRDGDRYSL---RQDGTKCELQ 3594

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP 543
            + G+   D GE +   G  RT+ +L V+ +       PI  +  +G +N         E 
Sbjct: 3595 IRGLAMADTGEYSCVCGQERTSAMLTVRAL-------PI--KFTEGLRNE--------EA 3637

Query: 544  APETPFIYRLERQEVGSEDWIQCF---------SIEKAGA---VEVPGDCVPSEGDYRFR 591
                  + R E  ++   +W +           S+ + GA   +++ G      G+Y   
Sbjct: 3638 TEGATAVLRCELSKMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEY--- 3694

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
            +C + G  R+  ++   +   +P+ + + GL + +  +G+ A    +LS      W    
Sbjct: 3695 LC-MCGKERTSAML---TVRAMPS-KFIEGLRNEEATEGDTATLWCELSKAAPVEWRKGH 3749

Query: 652  EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD--SAALT 709
            E L+  +          R+ + Q G +  L +  +   D+G    +SC   Q+  SA LT
Sbjct: 3750 ETLRDGD----------RHSLRQDGSRCELQIRGLAVVDAGE---YSCVCGQERTSATLT 3796

Query: 710  IQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGR 769
            ++  P   +  +D  +         VL CELS+   P  W K  + +   +   ++ DG 
Sbjct: 3797 VRALPARFI--EDVKNQEAREGATAVLQCELSKAA-PVEWRKGSETLRGGDRYSLRQDGT 3853

Query: 770  KHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLAC 829
            +  L +    V D+GE+ C          +TV+ P     +P + +   A       L C
Sbjct: 3854 RCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFREPLQSL--QAEEGSTATLQC 3911

Query: 830  EVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFT 889
            E+    A V W K G +++ +       +G    LVL   Q  D GE+ C  G +    T
Sbjct: 3912 ELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTCGSQATSAT 3971

Query: 890  VTITDVSSWIVYPSGKVYVAAVRLERVV------------LTCELCRPWAEVRWTKDGEE 937
            +T+T               A VR  R +            L CEL R  A V W K   +
Sbjct: 3972 LTVT--------------AAPVRFLRELQHQEVDEGGTAHLCCELSRAGASVEWRKGSLQ 4017

Query: 938  VVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEV 997
            +       + ++     L++  V+ ED+G+Y C+        T ++    VR+  P+ + 
Sbjct: 4018 LFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCD-----TGHTQSMASLSVRVPRPKFKT 4072

Query: 998  TLIAV---TLECVVLMCELSRED--APVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQ 1052
             L ++   T +   L C+LS  +  A V+W K+G+E+       +   G    L++   +
Sbjct: 4073 RLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLE 4132

Query: 1053 PEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ- 1111
             +D GE+ C  G      ++ VT P   IV      +D    A   VE  CEV+ AG+  
Sbjct: 4133 AKDTGEYACVTGGQKTAASLRVTEPEVTIVRGL---VDAEVTADEDVEFSCEVSRAGATG 4189

Query: 1112 VRWYKDGLEVEASDALQLGA-EGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPP 1170
            V+W   GL +++++  ++   +G   TL L    PEDAG       + A +  + +  P 
Sbjct: 4190 VQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAPE 4249

Query: 1171 VQFLALETTPSPLCVAPGEPVVLSCELSRA-GAPVVWSHNGRPVQEGEGLELHAE-GPRR 1228
            V  L        + ++ G+     C LSRA G    W+  G P+Q  E  ++  E G   
Sbjct: 4250 VTILE---PLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLH 4306

Query: 1229 VLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLE 1288
            +L +       AG  +   G       L  T +     VR +        V +  GG+  
Sbjct: 4307 LLTLHKVTLEDAGTVSFHVGTCSSEAQLKVTAK--NTVVRGLE------NVEALEGGEAL 4358

Query: 1289 LVVHLSGPGGPVR-WYKDGERL--ASQGRVQLEQAGARQVLRVQGARSGD-------AGE 1338
                LS P      W  D E +  +    V   + G R +L ++  R  D       AG+
Sbjct: 4359 FECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGD 4418

Query: 1339 YLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSP--PDADVTWLRNG 1396
             +  A    R + + + EPL            V  G  A F C +S   P  + +W  NG
Sbjct: 4419 MVTSAFLTVRGWRLEILEPL--------KNAAVRAGAQACFTCTLSEAVPVGEASWYING 4470

Query: 1397 AVVTPGPQV-EMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR------ETEL 1449
            A V P      +  +GS   L LR  Q   AG VT        SARL V       E   
Sbjct: 4471 AAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLTVLGLPDPPEDAE 4530

Query: 1450 LFLRRLQDVR-------AEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG 1502
            +  R    V        ++ G  +C      + GA G  R      P P      +A  G
Sbjct: 4531 VVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAP-G 4589

Query: 1503 HIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPL-EDVTISEGGSATFQL 1561
              +R  +  V     G    E  H     RL+  P+ +       E   ++ G   + +L
Sbjct: 4590 ETYRFRVAAVGPVGAG----EPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLEL 4645

Query: 1562 ELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSFTADSLRC 1618
            E+  E     W +G  ++ PG +  + S G +  LV+ G    D G   C          
Sbjct: 4646 EVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHCGLAQGSICPA 4705

Query: 1619 AARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQA 1678
            AA   V   P ++   P      E         L +ALA          L     L  + 
Sbjct: 4706 AATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMSREPTLDSISELPEED 4765

Query: 1679 LGTRRLLQ-LRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGAT 1737
              ++RL Q      P  +  YS A   AR G              ++L   S+ +   A 
Sbjct: 4766 GRSQRLPQEAEEVAPDLSEGYSTADELARTGD-------------ADLSHTSSDDESRAG 4812

Query: 1738 FECTVSEVETTGRWELG------GRPLRPGARVRIRQEGKKHILV-LSELRAEDAGE--- 1787
                V+ ++  GR          G P  P  + + +QE    +   L +L  +D G+   
Sbjct: 4813 TPSLVTYLKKAGRPGTSPLASKVGAPAAPSVKPQQQQEPLAAVRPPLGDLSTKDLGDPSM 4872

Query: 1788 ----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLE-VTVSRSGGHVCWL 1842
                V+ QA         E++     M  H   +    VG    LE V  S++     WL
Sbjct: 4873 DKAAVKIQAAFKGYKVRKEMKQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWL 4932

Query: 1843 REGAELCPGDKYEMRSHGP-THSLVIHDVRPEDQGTYCCQAGQ---DSTHTRLLV 1893
            ++G EL  G  + +   G  T SL+I  +   D G Y CQ        TH+  +V
Sbjct: 4933 KDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVV 4987



 Score =  178 bits (452), Expect = 4e-44
 Identities = 204/796 (25%), Positives = 316/796 (39%), Gaps = 94/796 (11%)

Query: 1178 TTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAG 1236
            T P    V+ G+   LSC++     P V W  + +PV  G    L  +G    L I    
Sbjct: 14   TRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLA 73

Query: 1237 PAHAGLYTCQSGAAPGAPSLSFTVQV-AEPPVRVVAPE--AAQTRVRSTPGGDLELVVHL 1293
               +G Y C++  A G    +  +QV AE      AP      T +R   G +      +
Sbjct: 74   LGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCRV 133

Query: 1294 SGPGGP-VRWYKDGERLASQG--RVQLEQAGARQVLRVQGARSGDAGEYLCDA------- 1343
             G   P V W KDG RL      RV++E+ G    LR++ AR  D G Y   A       
Sbjct: 134  GGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAA 193

Query: 1344 ------------------PQDSRIFLVSVEEPLLVKLVSELTPL----------TVHEGD 1375
                              P  S   L++  +     + +E  P           TV EG 
Sbjct: 194  SAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTEGK 253

Query: 1376 DATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSR-ILTLRGCQLGDAGTVTLRA 1433
             A   C V+  P  +  W ++G +VT G +  + ++     +L +  C+  D G  T  A
Sbjct: 254  HARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTA 313

Query: 1434 ----GSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQP 1489
                G T +S  + VRE  + F +RLQD+   E +      E  +     A  W +    
Sbjct: 314  SNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEAA--WFKEETR 371

Query: 1490 LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH-DRTLARLSVRPRQLRVLRPLED 1548
            L   ++  + ++G   RL +  V   D   Y CE+    RT+A L+V+   LR L     
Sbjct: 372  LWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQGNLLRKLPRKTA 431

Query: 1549 VTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC 1608
            V +  G +A F +EL+       W R   ++  G +  I ++G RH L ++   L D G 
Sbjct: 432  VRV--GDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQ 489

Query: 1609 VSFTADSLRCAARLIV---REVPVT-----IVRG-------------PHDLEVTEGDTAT 1647
            V+F A   + + +  V   R+ P+      +V+              PH       D   
Sbjct: 490  VAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYL 549

Query: 1648 FECELSQALADVTWEKDGNA-LTPSPRLRLQALGTRRLLQLRRCGPSDAGT--YSCAVGT 1704
             E    + L   TW +   A    +P L +  +      Q R    +  G   Y    GT
Sbjct: 550  VE---KKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGT 606

Query: 1705 ARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARV 1764
                P         +AV + L++V A EG   TF   ++ V + G W L G+ L+  +  
Sbjct: 607  VHLAP--------KLAVRTPLKAVQAVEGGEVTFSVDLT-VASAGEWFLDGQALKASSVY 657

Query: 1765 RIRQEGKKHILVLSELRAEDAG-EVRFQAGPAQSLALLEVEALPLQMCRHPP----REKT 1819
             I  +  +H L + E+ A   G +++F A   +S   +EV A P      PP    RE  
Sbjct: 658  EIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVL 717

Query: 1820 VLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYC 1879
              +   A L   +S     V WL++G  L PG KYE+++      L++ DV  +D G Y 
Sbjct: 718  ARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYE 777

Query: 1880 CQAGQDSTHTRLLVEG 1895
            C +       +L V+G
Sbjct: 778  CVSRGGRIAYQLSVQG 793



 Score =  115 bits (287), Expect = 5e-25
 Identities = 114/388 (29%), Positives = 155/388 (39%), Gaps = 68/388 (17%)

Query: 126 GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAE 185
           GAP FLT P++  V  G +  L+C+  G P P + WEKD      V   + F L    A+
Sbjct: 8   GAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKD---QQPVAAGARFRL----AQ 60

Query: 186 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
           DG      L IL   L DSG YVC ARNA G A A   LQV         D + A A   
Sbjct: 61  DGD--LYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQV---------DAEAACAEQA 109

Query: 246 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVL 304
                 P +  V EG  A FRC V G P P + W  +GR L  PD  R+   +      L
Sbjct: 110 PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASAL 169

Query: 305 KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV---------------------------- 336
           ++   + +D G Y   A N  G   +A  L V                            
Sbjct: 170 RIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREA 229

Query: 337 -------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRK--- 385
                    P    TR     EG+    A L C V     P T W ++ Q +   R+   
Sbjct: 230 MRAEGAPASPPSTGTRTCTVTEGKH---ARLSCYVTGEPKPETVWKKDGQLVTEGRRHVV 286

Query: 386 YEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVKGPIL--KRLPRKLDV 440
           YE  +E  V +++    K  D G+Y C    + G+  +   V V+ P +  K+  + L+V
Sbjct: 287 YEDAQENFVLKILF--CKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEV 344

Query: 441 LEGENAVLLVETLEAGVEGRWSRDGEEL 468
            E E+A  L E  +   E  W ++   L
Sbjct: 345 REKESATFLCEVPQPSTEAAWFKEETRL 372



 Score =  101 bits (252), Expect = 6e-21
 Identities = 102/352 (28%), Positives = 137/352 (38%), Gaps = 38/352 (10%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG-AEHGLL 70
            P FL   +   V  G      CVV G+P P V W K G+ L   +      D    H L+
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLI 5185

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTV------LEPPASDPE----------LQPA 114
            +TA +P D GVY C A N+ G +   A + V       +  A   E          L   
Sbjct: 5186 ITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSR 5245

Query: 115  ERPLPSPGSGEGA-PVFLTGPRSQWVLRGAEVV-LTCRAGGLPEPTLYWEKDGMALDEVW 172
            E+      + EG  P  +   R   V  G  +     +  G P P LYW KDG  L    
Sbjct: 5246 EQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTA-- 5303

Query: 173  DSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVH---QP 229
             S+H  +   +          L I++    DSG Y  +  NA G A + A L V    +P
Sbjct: 5304 -SAHIRMTDKKILH------TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEP 5356

Query: 230  PESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG--RPLL 287
             E P +D  E   P     +  PK   V +G    F   V G+P P + W  E   R +L
Sbjct: 5357 EEKPASDVHEQLVPPRMLERFTPKK--VKKGSSITFSVKVEGRPVPTVHWLREEAERGVL 5414

Query: 288  ---PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
               PD              L +L    + +G Y C A N+AGQ L +  LHV
Sbjct: 5415 WIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHV 5466



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 63/221 (28%), Positives = 97/221 (43%), Gaps = 29/221 (13%)

Query: 142  GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
            G  V L CR  G P+P + W KDG A+    D  H  ++       P  S AL + +   
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQV--DPHHILIED------PDGSCALILDSLTG 6079

Query: 202  PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGK 261
             DSG Y+C A +A G+      + V  PP              V  ++ +P      EG+
Sbjct: 6080 VDSGQYMCFAASAAGNCSTLGKILVQVPPR------------FVNKVRASPFV----EGE 6123

Query: 262  HAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
             A+F C + G P P+I W+ +G  L    + + +   R G  VL +     +D GLY C 
Sbjct: 6124 DAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECE 6183

Query: 321  ARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLE 361
              N  G   ++ +L ++ P L+     Q+   RE  +A +E
Sbjct: 6184 LVNRLGSARASAELRIQSPMLQ----AQEQCHREQLVAAVE 6220



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 83/279 (29%), Positives = 115/279 (41%), Gaps = 50/279 (17%)

Query: 103  EPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWE 162
            E PA  P + P   PLPS  + + APVFLT  ++Q V  G  V   C   G P P++ W 
Sbjct: 5105 ETPA--PVVPP--EPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWF 5160

Query: 163  KDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGA 222
            KDG  L+E     H+ +     ED  G    L I A    D GVY C A N+ G +   A
Sbjct: 5161 KDGKLLEE---DDHYMIN----EDQQGGH-QLIITAVVPADMGVYRCLAENSMGVSSTKA 5212

Query: 223  LLQVH---------------------------QPPESPPADPDEAPAP-VVEPLK---CA 251
             L+V                            +  E   +  DE   P VVE L+    A
Sbjct: 5213 ELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVA 5272

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            P T      + AKF+  V G P P + W  +G+PL      +   D+     L+++    
Sbjct: 5273 PGT------RLAKFQLKVKGYPAPRLYWFKDGQPLTAS-AHIRMTDKKILHTLEIISVTR 5325

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDV 350
            +D G Y     N+ G   S+ +L V+ P     +P  DV
Sbjct: 5326 EDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDV 5364



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 61/229 (26%), Positives = 92/229 (40%), Gaps = 10/229 (4%)

Query: 4    SSGDQGSPPCFLRFPRPVRVVSGAE-AELKCVVLGEPPPVVVWEKGGQQLAASERLSFPA 62
            S+ D+G  P  +   R ++V  G   A+ +  V G P P + W K GQ L AS  +    
Sbjct: 5252 STTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTD 5311

Query: 63   DGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
                H L + +    D+G Y     NA G AY++A + V  P       +P E+P     
Sbjct: 5312 KKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPD------EPEEKPASDVH 5365

Query: 123  SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPG 182
                 P  L     + V +G+ +  + +  G P PT++W ++      +W        PG
Sbjct: 5366 EQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPD---TPG 5422

Query: 183  RAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE 231
                      +L +L       G Y C A NA G A   A L V   P+
Sbjct: 5423 YTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPK 5471



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 127/506 (25%), Positives = 194/506 (38%), Gaps = 61/506 (12%)

Query: 947  QKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLEC 1006
            ++ED+VR+ +L A        ++ EI        + V  PP    +  +     A   E 
Sbjct: 5974 EREDSVRKYLLQARTAIIKSSWVKEICGIQQRLALPVWRPPD---FEEELADCTAELGET 6030

Query: 1007 VVLMCELSREDAPV-RWYKDG--LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC-- 1061
            V L C ++    PV  WYKDG  ++V+    L+ + DG  C L+L +    D G+++C  
Sbjct: 6031 VKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGS-CALILDSLTGVDSGQYMCFA 6089

Query: 1062 --DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGL 1119
               AG+ S    + V  PP R V+    S  +  G   +     E AP   Q+RWYKDG 
Sbjct: 6090 ASAAGNCSTLGKILVQVPP-RFVNKVRASPFVE-GEDAQFTCTIEGAPY-PQIRWYKDGA 6146

Query: 1120 EVEASDALQLGAEGPTRTLTL--PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALE 1177
             +   +  Q  +E  +  L L    A  ED G Y CE  +   +     AE  +Q     
Sbjct: 6147 LLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARA-SAELRIQ----- 6200

Query: 1178 TTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGP 1237
               SP+  A  +     C   +  A V  +   R  QE   +     GP+      A GP
Sbjct: 6201 ---SPMLQAQEQ-----CHREQLVAAVEDTTLERADQEVTSVLKRLLGPK------APGP 6246

Query: 1238 AHAGLYTCQSGAAPGAPSLSFTVQVAEPPVR------VVAPEAAQTRVRSTPGGDLELVV 1291
            +  G  T       GAP+L  T   ++PPV        V P   Q  +   P  + E + 
Sbjct: 6247 S-TGDLTGPGPCPRGAPALQET--GSQPPVTGTSEAPAVPPRVPQPLLHEGPEQEPEAIA 6303

Query: 1292 HLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL 1351
                   P+R   +G      G  +L       V+R    R+     Y   A     I  
Sbjct: 6304 RAQEWTVPIR--MEGAAWPGAGTGELLWDVHSHVVRETTQRT-----YTYQA-----IDT 6351

Query: 1352 VSVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQN 1410
             +   P +   + ++   T   G  A F   +   P   VTW ++   +    ++   Q 
Sbjct: 6352 HTARPPSMQVTIEDVQAQT---GGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQE 6408

Query: 1411 GSSRILTLRGCQLGDAGTVTLRAGST 1436
            G++  L LR     DAG  T  A +T
Sbjct: 6409 GTTYSLVLRHVASKDAGVYTCLAQNT 6434



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 11/181 (6%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G+  K  C V G P+P I W+ +G+ +  D   ++  D DG   L +      D G Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087

Query: 320  AARNSAG--QTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFRE 376
             A ++AG   TL  + + V    +   R    VEG +   A   C +  +  P   W+++
Sbjct: 6088 FAASAAGNCSTLGKILVQVPPRFVNKVRASPFVEGED---AQFTCTIEGAPYPQIRWYKD 6144

Query: 377  DQRLLPCRKYEQIEE--GTVRRLIIHRLKADDDGIYLCEM---RGRVRTVANVTVKGPIL 431
               L    K++ + E    +  L+I     +D G+Y CE+    G  R  A + ++ P+L
Sbjct: 6145 GALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPML 6204

Query: 432  K 432
            +
Sbjct: 6205 Q 6205



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 84/373 (22%), Positives = 143/373 (38%), Gaps = 80/373 (21%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER---LSFPADGAEH 67
            PP F+   R    V G +A+  C + G P P + W K G  L    +   LS P  G   
Sbjct: 6107 PPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL-L 6165

Query: 68   GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEP---------------PASDPELQ 112
             L++ AA   D G+Y C   N  G A A+A + +  P                  D  L+
Sbjct: 6166 VLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQCHREQLVAAVEDTTLE 6225

Query: 113  PAERPL------------PSPGSGEGAPVFLTG----PRSQWVLR--GAEVVLTCRAGG- 153
             A++ +            P P +G+     LTG    PR    L+  G++  +T  +   
Sbjct: 6226 RADQEVTSVLKRLLGPKAPGPSTGD-----LTGPGPCPRGAPALQETGSQPPVTGTSEAP 6280

Query: 154  -----LPEPTLY----WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDS 204
                 +P+P L+     E + +A  + W                  ++ +R+  A  P +
Sbjct: 6281 AVPPRVPQPLLHEGPEQEPEAIARAQEW------------------TVPIRMEGAAWPGA 6322

Query: 205  GV-YVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHA 263
            G   +    ++H   +       +Q  ++  A P      +        +      G  A
Sbjct: 6323 GTGELLWDVHSHVVRETTQRTYTYQAIDTHTARPPSMQVTI--------EDVQAQTGGTA 6374

Query: 264  KFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARN 323
            +F   + G P+P + W+ +   L+ D  RL  +     + L + +  +KD G+Y C A+N
Sbjct: 6375 QFEAIIEGDPQPSVTWYKDSVQLV-DSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQN 6433

Query: 324  SAGQTLSAVQLHV 336
            + GQ L   +L V
Sbjct: 6434 TGGQVLCKAELLV 6446



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 59/206 (28%), Positives = 81/206 (39%), Gaps = 33/206 (16%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQ--QLAASERLSFPADGAEHGLLLTAALPTDAGVYV 83
            G   +L C V G P PV+ W K G+  Q+     L    DG+   L+L +    D+G Y+
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGS-CALILDSLTGVDSGQYM 6086

Query: 84   CRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGA 143
            C A +AAG       + V  PP                        F+   R+   + G 
Sbjct: 6087 CFAASAAGNCSTLGKILVQVPPR-----------------------FVNKVRASPFVEGE 6123

Query: 144  EVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPD 203
            +   TC   G P P + W KDG  L     +    L   R+       L L I AA   D
Sbjct: 6124 DAQFTCTIEGAPYPQIRWYKDGALL--TTGNKFQTLSEPRS-----GLLVLVIRAASKED 6176

Query: 204  SGVYVCHARNAHGHAQAGALLQVHQP 229
             G+Y C   N  G A+A A L++  P
Sbjct: 6177 LGLYECELVNRLGSARASAELRIQSP 6202



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 126/569 (22%), Positives = 182/569 (31%), Gaps = 118/569 (20%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG-AEHGLLLTAALPTDAGVYVC 84
            G    L+CVV  +      W K G +L           G     LL+T     DAG Y C
Sbjct: 4912 GDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTC 4971

Query: 85   RARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF---------LTGPR 135
            +  N  G+   +A V V            +E    S   GE    F         L   +
Sbjct: 4972 QVSNKFGQVTHSACVVV----------SGSESEAESSSGGELDDAFRRAARRLHRLFRTK 5021

Query: 136  SQWVLRGAEVVLTCRAG-GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLAL 194
            S   +   E+ L+   G   PE    W+          +  HF     R E    A  A+
Sbjct: 5022 SPAEVSDEELFLSADEGPAEPEEPADWQ-------TYREDEHFICI--RFEALTEARQAV 5072

Query: 195  RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADP-------DEAPAPVVEP 247
                      G+ V       G  +    +    P    P +P       D AP  + E 
Sbjct: 5073 TRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTE- 5131

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
                 +   V +G    F C V G+P P + W  +G+ L  D   ++  D+ GG  L + 
Sbjct: 5132 ----LQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIIT 5187

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHV-------------KEPRLRFT---------- 344
                 D G+Y C A NS G + +  +L V              E    F+          
Sbjct: 5188 AVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQ 5247

Query: 345  -------------------RPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCR 384
                               R LQ   G    +A  + KV     P   WF++ Q L    
Sbjct: 5248 EGTESTTDEGQLPQVVEELRDLQVAPGTR--LAKFQLKVKGYPAPRLYWFKDGQPLTASA 5305

Query: 385  KYEQIEEGTVRRLIIHRLKADDDG---IYLCEMRGRVRTVANVTVKGPILKRLPRKLDVL 441
                 ++  +  L I  +  +D G    Y+    G   + A + V+GP         DV 
Sbjct: 5306 HIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVH 5365

Query: 442  EGENAVLLVE-------------TLEAGVEGR------WSRD---------GEELPVICQ 473
            E      ++E             T    VEGR      W R+         G + P    
Sbjct: 5366 EQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTV 5425

Query: 474  SSSGHMHALVLPGVTREDAGEVTFSLGNS 502
            +SS   H+LVL  V R+  G  T    N+
Sbjct: 5426 ASSAQQHSLVLLDVGRQHQGTYTCIASNA 5454



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 40/114 (35%), Positives = 53/114 (46%), Gaps = 7/114 (6%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP        V+  +G  A+ + ++ G+P P V W K   QL  S RLS   +G  + L+
Sbjct: 6356 PPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLV 6415

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVL----EPPASDPELQPAERPLPS 120
            L      DAGVY C A+N  G+    A + VL    EP   D E Q   R L S
Sbjct: 6416 LRHVASKDAGVYTCLAQNTGGQVLCKAELLVLGGDNEP---DSEKQSHRRKLHS 6466



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 108/456 (23%), Positives = 158/456 (34%), Gaps = 83/456 (18%)

Query: 914  ERVVLTCELC-RPWAEVRWTKDGEEVVESPA-LLLQKEDTVRRLVLPAVQLEDSGEYLCE 971
            E V L C +   P   + W KDG+ V   P  +L++  D    L+L ++   DSG+Y+C 
Sbjct: 6029 ETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCF 6088

Query: 972  IDDESASFT----VTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDG 1026
                + + +    + V  PP  +   R       V  E     C +     P +RWYKDG
Sbjct: 6089 AASAAGNCSTLGKILVQVPPRFVNKVRASP---FVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 1027 --LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCD----AGDDSAFFTVTVTAPPER 1080
              L        + E       LV+ AA  ED G + C+     G   A   + + +P  +
Sbjct: 6146 ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQ 6205

Query: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGP---TRT 1137
                  R                ++  A       +   EV +     LG + P   T  
Sbjct: 6206 AQEQCHRE---------------QLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGD 6250

Query: 1138 LTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCEL 1197
            LT P   P  A                    P +Q    +   +    AP  P       
Sbjct: 6251 LTGPGPCPRGA--------------------PALQETGSQPPVTGTSEAPAVP------- 6283

Query: 1198 SRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG------LYTCQSGAAP 1251
             R   P++  H G P QE E +   A      + I+  G A  G      L+   S    
Sbjct: 6284 PRVPQPLL--HEG-PEQEPEAI---ARAQEWTVPIRMEGAAWPGAGTGELLWDVHSHVVR 6337

Query: 1252 GAPSLSFTVQ-----VAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKD 1305
                 ++T Q      A PP   V  E  Q +     GG  +    + G P   V WYKD
Sbjct: 6338 ETTQRTYTYQAIDTHTARPPSMQVTIEDVQAQT----GGTAQFEAIIEGDPQPSVTWYKD 6393

Query: 1306 GERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
              +L    R+  +Q G    L ++   S DAG Y C
Sbjct: 6394 SVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTC 6429



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 15/179 (8%)

Query: 1284 GGDLELVVHLSGPGGPV-RWYKDGERL-ASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
            G  ++L   ++G   PV  WYKDG+ +      + +E       L +      D+G+Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087

Query: 1342 DAPQD----SRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNG 1396
             A       S +  + V+ P   + V+++      EG+DA F C +   P   + W ++G
Sbjct: 6088 FAASAAGNCSTLGKILVQVP--PRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 1397 AVVTPGPQVEMAQNGSSRILTL--RGCQLGDAG----TVTLRAGSTATSARLHVRETEL 1449
            A++T G + +      S +L L  R     D G     +  R GS   SA L ++   L
Sbjct: 6146 ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPML 6204



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 65/244 (26%), Positives = 98/244 (40%), Gaps = 20/244 (8%)

Query: 648  FLNGEELKSNEPEGQVEPGALRYRI--EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDS 705
            F N  +L S +   QVE     + +  E++    + +L A       + V   C G+Q  
Sbjct: 5947 FRNMMKLSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEIC-GIQQR 6005

Query: 706  AALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQ--KVEESELL 762
             AL +   P      ++    T    E V L C ++    P  +WYKDG+  +V+   +L
Sbjct: 6006 LALPVWRPPDF---EEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHIL 6062

Query: 763  VVKMDGRKHRLILPEAKVQDSGEFEC----RTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
            +   DG    LIL      DSG++ C         S    + VQ PP  +   R   FV 
Sbjct: 6063 IEDPDG-SCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVE 6121

Query: 819  AITSECVMLACEVDREDAP-VRWYKDGQEVEESD-FVVL-ENEGPHRRLVLPATQPSDGG 875
                E     C ++    P +RWYKDG  +   + F  L E       LV+ A    D G
Sbjct: 6122 ---GEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLG 6178

Query: 876  EFQC 879
             ++C
Sbjct: 6179 LYEC 6182



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 46/159 (28%), Positives = 69/159 (43%), Gaps = 12/159 (7%)

Query: 823  ECVMLACEVDREDAPV-RWYKDGQEVE-ESDFVVLENEGPHRRLVLPATQPSDGGEFQCV 880
            E V LAC V     PV  WYKDG+ V+ +   +++E+      L+L +    D G++ C 
Sbjct: 6029 ETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCF 6088

Query: 881  AGD---ECAYFTVTITDVSSWIVYPSGKVYVAA-VRLERVVLTCEL-CRPWAEVRWTKDG 935
            A      C+     +  V    V    KV  +  V  E    TC +   P+ ++RW KDG
Sbjct: 6089 AASAAGNCSTLGKILVQVPPRFV---NKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDG 6145

Query: 936  EEVVESPAL--LLQKEDTVRRLVLPAVQLEDSGEYLCEI 972
              +        L +    +  LV+ A   ED G Y CE+
Sbjct: 6146 ALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECEL 6184



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 32/99 (32%), Positives = 39/99 (39%), Gaps = 1/99 (1%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL- 70
            P FLR      VV G    L C V  +P     W K G  L +S R+   A      LL 
Sbjct: 7463 PTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLT 7522

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP 109
            +   +  D GVY C   NA G       +   E P+S P
Sbjct: 7523 ILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSP 7561



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 87/336 (25%), Positives = 116/336 (34%), Gaps = 82/336 (24%)

Query: 1639 EVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQA--LGTRRLLQLRRCGPSDA 1695
            EV +G   +F+C ++ Q +  V W KDG  L       +     G  +L+ +    P+D 
Sbjct: 5136 EVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLI-ITAVVPADM 5194

Query: 1696 GTYSC------AVGTARA------------------------------------GPVRLT 1713
            G Y C       V + +A                                    G    T
Sbjct: 5195 GVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTT 5254

Query: 1714 VRERTVAVLSELRSVSAREGDG-ATFECTVSEVETTGR-WELGGRPLRPGARVRIRQEGK 1771
               +   V+ ELR +    G   A F+  V         W   G+PL   A +R+  +  
Sbjct: 5255 DEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKI 5314

Query: 1772 KHILVLSELRAEDAGE----VRFQAGPAQSLALL------EVEALPLQMCRH---PPR-- 1816
             H L +  +  ED+G+    +    G A S A L      E E  P         PPR  
Sbjct: 5315 LHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRML 5374

Query: 1817 ----EKTVLVGRRAVLEVTVS-RSGGHVCWLREGAEL--------CPGDKYEMRSHGPTH 1863
                 K V  G      V V  R    V WLRE AE          PG  Y + S    H
Sbjct: 5375 ERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPG--YTVASSAQQH 5432

Query: 1864 SLVIHDVRPEDQGTYCC----QAGQDSTHTRLLVEG 1895
            SLV+ DV  + QGTY C     AGQ      L V G
Sbjct: 5433 SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSG 5468



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 122/566 (21%), Positives = 184/566 (32%), Gaps = 135/566 (23%)

Query: 1001 AVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGP-RCRLVLPAAQPEDGGEF 1059
            A+ LECVV     S+ D   RW KDG+E+ +     +++ G   C L++      D G +
Sbjct: 4914 ALRLECVVA----SKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCY 4969

Query: 1060 VCDAGDDSAFFT----VTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWY 1115
             C   +     T    V V+         +   LD  F    R   R             
Sbjct: 4970 TCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARRLHRLFRT--------- 5020

Query: 1116 KDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT--------FNVILA 1167
            K   EV   +      EGP         Q     E+    R EA+T        F  + A
Sbjct: 5021 KSPAEVSDEELFLSADEGPAEPEEPADWQTYREDEHFICIRFEALTEARQAVTRFQEMFA 5080

Query: 1168 ------------------------EPPVQFLALETTPSPLC---------------VAPG 1188
                                    E P   +  E  PS L                V  G
Sbjct: 5081 TLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDG 5140

Query: 1189 EPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPR-RVLCIQAAGPAHAGLYTCQ 1246
             PV   C ++    P V W  +G+ ++E +   ++ +      L I A  PA  G+Y C 
Sbjct: 5141 YPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCL 5200

Query: 1247 SGAAPGAPSLSFTVQV---------AEPPVRVVAPEAAQTRVRS---------TPGGDLE 1288
            +  + G  S    ++V         A       +  +AQ  + S         T  G L 
Sbjct: 5201 AENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLP 5260

Query: 1289 LVVH-------------------LSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRV 1328
             VV                    + G P   + W+KDG+ L +   +++        L +
Sbjct: 5261 QVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEI 5320

Query: 1329 QGARSGDAGEY-------LCDAPQDSRIFLVSVEEP------------LLVKLVSELTPL 1369
                  D+G+Y       +  A   +R+ +   +EP            +  +++   TP 
Sbjct: 5321 ISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPK 5380

Query: 1370 TVHEGDDATFRCEV-SPPDADVTWLRNGA---VVTPGPQV---EMAQNGSSRILTLRGCQ 1422
             V +G   TF  +V   P   V WLR  A   V+  GP      +A +     L L    
Sbjct: 5381 KVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVG 5440

Query: 1423 LGDAGTVTL----RAGSTATSARLHV 1444
                GT T      AG    SA LHV
Sbjct: 5441 RQHQGTYTCIASNAAGQALCSASLHV 5466



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 44/140 (31%), Positives = 53/140 (37%), Gaps = 11/140 (7%)

Query: 104  PPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEK 163
            PP   P L  A   L    S + AP FL     + V+ G  V L C+    P     W K
Sbjct: 7441 PPRKKPGL--ASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSK 7498

Query: 164  DGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH-AQAGA 222
            DG  L    +SS   L     ++       L IL     D GVY C   NA G     G 
Sbjct: 7499 DGAPL----ESSSRVLISATLKN----FQLLTILVVVAEDLGVYTCSVSNALGTVTTTGV 7550

Query: 223  LLQVHQPPESPPADPDEAPA 242
            L +  +P  SP  D  E  A
Sbjct: 7551 LRKAERPSSSPCPDIGEVYA 7570



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 42/195 (21%), Positives = 78/195 (40%), Gaps = 45/195 (23%)

Query: 825  VMLACEVDREDAP-VRWYKDGQEVEESD-FVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882
            V   C V  +  P VRW+KDG+ +EE D +++ E++    +L++ A  P+D G ++C+A 
Sbjct: 5143 VSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAE 5202

Query: 883  DECAYFTV--------------TITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR---- 924
            +     +               T  D +    Y S + Y+++   E    T +  +    
Sbjct: 5203 NSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQV 5262

Query: 925  -------------------------PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPA 959
                                     P   + W KDG+ +  S  + +  +  +  L + +
Sbjct: 5263 VEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIIS 5322

Query: 960  VQLEDSGEYLCEIDD 974
            V  EDSG+Y   I +
Sbjct: 5323 VTREDSGQYAAYISN 5337



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 127/609 (20%), Positives = 209/609 (34%), Gaps = 144/609 (23%)

Query: 741  SRVDFPATWYKDGQKVEESELLVVKMDGRKHR----------LILPEAKVQDSGEFECRT 790
            S+ D  A W KDG ++          DGR H           L++      D+G + C+ 
Sbjct: 4923 SKADVRARWLKDGVELT---------DGRHHHIDQLGDGTCSLLITGLDRADAGCYTCQ- 4972

Query: 791  EGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEES 850
              VS  FG       V +V   E     +   E         R    +   K   EV + 
Sbjct: 4973 --VSNKFGQVTHSACV-VVSGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSDE 5029

Query: 851  DFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDE---CAYFTVTITDVSSWIVYPSGKVY 907
            +  +  +EGP         +P +  ++Q    DE   C  F   +T+             
Sbjct: 5030 ELFLSADEGP--------AEPEEPADWQTYREDEHFICIRFEA-LTEARQ---------- 5070

Query: 908  VAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGE 967
             A  R + +  T  +     E++  + G   VE   + + KE        P V  E    
Sbjct: 5071 -AVTRFQEMFATLGI---GVEIKLVEQGPRRVE---MCISKETPA-----PVVPPEPLPS 5118

Query: 968  YLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGL 1027
             L    D +  F   +    V+  YP        V+ +CVV      +    VRW+KDG 
Sbjct: 5119 LLTS--DAAPVFLTELQNQEVQDGYP--------VSFDCVVT----GQPMPSVRWFKDGK 5164

Query: 1028 EVEESEALVLERDGP-RCRLVLPAAQPEDGGEFVC------------------------- 1061
             +EE +  ++  D     +L++ A  P D G + C                         
Sbjct: 5165 LLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYD 5224

Query: 1062 ---DAGDDSAFFTV-----------TVTAPPERIVHPAARSLDLHFGAPG----RVELRC 1103
               DA + S++F+            T +   E  +      L     APG    + +L+ 
Sbjct: 5225 TAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKV 5284

Query: 1104 EVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE---YVCETRHEAI 1160
            +  PA  ++ W+KDG  + AS  +++  +    TL +     ED+G+   Y+      A 
Sbjct: 5285 KGYPA-PRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAY 5343

Query: 1161 TFNVILA-------EPPVQFLALETTP-------SPLCVAPGEPVVLSCELSRAGAPVVW 1206
            +   +L        E P   +  +  P       +P  V  G  +  S ++   G PV  
Sbjct: 5344 SSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVE--GRPVPT 5401

Query: 1207 SHNGRPVQE---------GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLS 1257
             H  R   E           G  + +   +  L +   G  H G YTC +  A G    S
Sbjct: 5402 VHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCS 5461

Query: 1258 FTVQVAEPP 1266
             ++ V+  P
Sbjct: 5462 ASLHVSGLP 5470



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 26/65 (40%), Positives = 30/65 (46%), Gaps = 1/65 (1%)

Query: 1637 DLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
            D++   G TA FE  +       VTW KD   L  S RL  Q  GT   L LR     DA
Sbjct: 6365 DVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDA 6424

Query: 1696 GTYSC 1700
            G Y+C
Sbjct: 6425 GVYTC 6429



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 2/78 (2%)

Query: 1630 TIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQA-LGTRRLLQL 1687
            T +R   D  V  G + T  C++S Q  A  TW KDG  L  S R+ + A L   +LL +
Sbjct: 7464 TFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTI 7523

Query: 1688 RRCGPSDAGTYSCAVGTA 1705
                  D G Y+C+V  A
Sbjct: 7524 LVVVAEDLGVYTCSVSNA 7541



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 7/106 (6%)

Query: 328  TLSAVQLHV-KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRK 385
            T  A+  H  + P ++ T  ++DV+ +  G A  E  +     P+  W+++  +L+   +
Sbjct: 6345 TYQAIDTHTARPPSMQVT--IEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTR 6402

Query: 386  YEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVKG 428
              Q +EGT   L++  + + D G+Y C      G+V   A + V G
Sbjct: 6403 LSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLG 6448



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 47/192 (24%), Positives = 79/192 (41%), Gaps = 32/192 (16%)

Query: 440  VLEGENAVLLVE-TLEAGVEGRWSRDGEELP----VICQSSSGHMHALVLPGVTREDAGE 494
            V+ G++  L  + + +   +  WS+DG  L     V+  ++  +   L +  V  ED G 
Sbjct: 7474 VVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGV 7533

Query: 495  VTFSLGNSR---TTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIY 551
             T S+ N+    TTT +  K  + S    P + E++    + VLL WKP E      +I 
Sbjct: 7534 YTCSVSNALGTVTTTGVLRKAERPSSSPCPDIGEVYA---DGVLLVWKPVESYGPVTYIV 7590

Query: 552  RLERQ-----EVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPH--- 603
            +   +      + S+ +  C+   K          +   G Y FR   VS  G  P+   
Sbjct: 7591 QCSLEGGSWTTLASDIFDCCYLTSK----------LSRGGTYTFRTACVSKAGMGPYSSP 7640

Query: 604  ---VVFHGSAHL 612
               V+  G +HL
Sbjct: 7641 SEQVLLGGPSHL 7652



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 64/274 (23%), Positives = 102/274 (37%), Gaps = 57/274 (20%)

Query: 1450 LFLRRLQDVRAEEGQDVCLE-VETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHI-HRL 1507
            +FL  LQ+   ++G  V  + V TG+     +VRW + G+ L  D    + +D    H+L
Sbjct: 5127 VFLTELQNQEVQDGYPVSFDCVVTGQ--PMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184

Query: 1508 FIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEG 1567
             I  V+ AD G Y C + +      +S    +LRV     D+T ++  +A    E S   
Sbjct: 5185 IITAVVPADMGVYRCLAENS---MGVSSTKAELRV-----DLTSTDYDTAADATESSS-- 5234

Query: 1568 VTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGL-GLADSGCVSFTADSLRCAARLIVRE 1626
                              +  + G+       G     D G +    + LR         
Sbjct: 5235 ------------------YFSAQGYLSSREQEGTESTTDEGQLPQVVEELR--------- 5267

Query: 1627 VPVTIVRGPHDLEVTEGD-TATFECELSQALAD-VTWEKDGNALTPSPRLRLQALGTRRL 1684
                      DL+V  G   A F+ ++    A  + W KDG  LT S  +R+        
Sbjct: 5268 ----------DLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHT 5317

Query: 1685 LQLRRCGPSDAGTYSCAVGTARA---GPVRLTVR 1715
            L++      D+G Y+  +  A        RL VR
Sbjct: 5318 LEIISVTREDSGQYAAYISNAMGAAYSSARLLVR 5351



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 9/84 (10%)

Query: 153  GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHAR 212
            G P+P++ W KD + L    DS+  + Q    ++G   SL LR +A++  D+GVY C A+
Sbjct: 6382 GDPQPSVTWYKDSVQLV---DSTRLSQQ----QEGTTYSLVLRHVASK--DAGVYTCLAQ 6432

Query: 213  NAHGHAQAGALLQVHQPPESPPAD 236
            N  G     A L V      P ++
Sbjct: 6433 NTGGQVLCKAELLVLGGDNEPDSE 6456



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 47/177 (26%), Positives = 67/177 (37%), Gaps = 31/177 (17%)

Query: 1483 WVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDR----TLARLSVRPR 1538
            W + GQPL   + + M     +H L I  V   D G Y     +      + ARL VR  
Sbjct: 5294 WFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGP 5353

Query: 1539 QLRVLRPLEDV----------------TISEGGSATFQLELSQEGV-TGEWARGGVQ--- 1578
                 +P  DV                 + +G S TF +++    V T  W R   +   
Sbjct: 5354 DEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGV 5413

Query: 1579 LYPGPKC---HIHSDGHRHRLVLNGLGLADSG---CV-SFTADSLRCAARLIVREVP 1628
            L+ GP      + S   +H LVL  +G    G   C+ S  A    C+A L V  +P
Sbjct: 5414 LWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLP 5470



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 19/67 (28%), Positives = 30/67 (44%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G+     C V  +P  +  W  +G PL    R L+        +L +L   A+D G+Y C
Sbjct: 7477 GQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTC 7536

Query: 320  AARNSAG 326
            +  N+ G
Sbjct: 7537 SVSNALG 7543



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 4/61 (6%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTHTRLLVE 1894
            V W ++  +L    +   +  G T+SLV+  V  +D G Y C A    GQ      LLV 
Sbjct: 6388 VTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVL 6447

Query: 1895 G 1895
            G
Sbjct: 6448 G 6448



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 2/94 (2%)

Query: 1185 VAPGEPVVLSCELS-RAGAPVVWSHNGRPVQEGEGLELHAEGPR-RVLCIQAAGPAHAGL 1242
            V  G+ V L+C++S +  A   WS +G P++    + + A     ++L I        G+
Sbjct: 7474 VVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGV 7533

Query: 1243 YTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQ 1276
            YTC    A G  + +  ++ AE P     P+  +
Sbjct: 7534 YTCSVSNALGTVTTTGVLRKAERPSSSPCPDIGE 7567



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 2/71 (2%)

Query: 914  ERVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQKE-DTVRRLVLPAVQLEDSGEYLCE 971
            + V L C++  +P A+  W+KDG  +  S  +L+       + L +  V  ED G Y C 
Sbjct: 7478 QSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCS 7537

Query: 972  IDDESASFTVT 982
            + +   + T T
Sbjct: 7538 VSNALGTVTTT 7548



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 11/98 (11%)

Query: 1534 SVRPRQLRVLRPLEDVTISEGGSATFQLELS---QEGVTGEWARGGVQLYPGPKCHIHSD 1590
            + RP  ++V   +EDV    GG+A F+  +    Q  VT  W +  VQL    +     +
Sbjct: 6353 TARPPSMQVT--IEDVQAQTGGTAQFEAIIEGDPQPSVT--WYKDSVQLVDSTRLSQQQE 6408

Query: 1591 GHRHRLVLNGLGLADSG---CVS-FTADSLRCAARLIV 1624
            G  + LVL  +   D+G   C++  T   + C A L+V
Sbjct: 6409 GTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV 6446



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 26/95 (27%), Positives = 39/95 (41%), Gaps = 1/95 (1%)

Query: 1725 LRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
            +  V A+ G  A FE  +  + + +  W      L    R+  +QEG  + LVL  + ++
Sbjct: 6363 IEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASK 6422

Query: 1784 DAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREK 1818
            DAG     A       L + E L L     P  EK
Sbjct: 6423 DAGVYTCLAQNTGGQVLCKAELLVLGGDNEPDSEK 6457



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 13/41 (31%), Positives = 23/41 (56%)

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC 788
            TWYKD  ++ +S  L  + +G  + L+L     +D+G + C
Sbjct: 6389 TWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTC 6429



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 1/66 (1%)

Query: 817  VHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            V A T         ++ +  P V WYKD  ++ +S  +  + EG    LVL      D G
Sbjct: 6366 VQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAG 6425

Query: 876  EFQCVA 881
             + C+A
Sbjct: 6426 VYTCLA 6431


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  461 bits (1185), Expect = e-129
 Identities = 389/1568 (24%), Positives = 676/1568 (43%), Gaps = 73/1568 (4%)

Query: 253   KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
             K   V E + A+F C +    E  + W  +G  ++    +          +L +   Q  
Sbjct: 11493 KDVTVPERRQARFECVLTR--EANVIWS-KGPDIIKSSDKFDIIADGKKHILVINDSQFD 11549

Query: 313   DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
             D G+Y        G+  SA +L V   RL+F  PL+D   +E   A   C++ + ++   
Sbjct: 11550 DEGVYTAEVE---GKKTSA-RLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVV 11605

Query: 373   WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
             WF+ D +L   R      EG   +L +  +  DD    + +++ +V+ +++ T +  +L+
Sbjct: 11606 WFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDD----ISQIKAQVKELSS-TAQLKVLE 11660

Query: 433   RLPRKLDVLEGENAVLLVE-TLEAGVEG----RWSRDGEEL---PVICQSSSGHMHALVL 484
               P     L  + AV   E TL+  V      +W +DGEE+   P     + G    L +
Sbjct: 11661 ADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKI 11720

Query: 485   PGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPA 544
                  +D GE     G  +T   + V+        P    E+F G      +    P+  
Sbjct: 11721 KKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVH 11780

Query: 545   PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
              +    ++L+ Q + +    +     K   + +    +   G+  F+    + + +S   
Sbjct: 11781 GQ----WKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQ----AANAKSAAN 11832

Query: 605   VFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
             +      L+     +  L DV+V++ ++A F  ++S   +   +L G          Q  
Sbjct: 11833 LKVKELPLI----FITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGT---------QEI 11879

Query: 665   PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
              G  R+ + + G +H +++ +   +D    + F       S  L I+   +  L+P   V
Sbjct: 11880 TGDDRFELIKDGTKHSMVIKSAAFEDEAKYM-FEAEDKHTSGKLIIEGIRLKFLTPLKDV 11938

Query: 725   SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
               T    E  V T ELS  +    W+K+ Q++  +  + ++ +G+ H +   +  + D+ 
Sbjct: 11939 --TAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTS 11996

Query: 785   EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDG 844
             +      G+S+   +TV +   +     +      +  + V+L CE+ + DAPV+W+KDG
Sbjct: 11997 QIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDG 12054

Query: 845   QEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSG 904
             +E++ S   V++ +G  R L+L     SD G++ C  G +     + I D    +V P  
Sbjct: 12055 KEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLH 12114

Query: 905   KVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLED 964
              V V      R     E+        W   GE ++++P   +++E  +  LVL   +L+ 
Sbjct: 12115 SVEVMETETAR--FETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQ 12172

Query: 965   SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
             +G    +  +  +S  + V    + ++ P  +VT+ A   E     CELS ED PV WY 
Sbjct: 12173 TGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAG--ETATFDCELSYEDIPVEWYL 12230

Query: 1025  DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHP 1084
              G ++E S+ +V   +G    L L   + ED GE    A D      + V  PP     P
Sbjct: 12231 KGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKP 12290

Query: 1085  AARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQ 1144
                  D          L CEV+   ++V+W+K+G E+  S   ++ A+G  R L +    
Sbjct: 12291 LE---DQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCT 12347

Query: 1145  PEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV 1204
             PED   Y C+ +    + N+ +  P V+FL   T    L V   E     CELSR  A V
Sbjct: 12348 PEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTD---LQVREKEMARFECELSRENAKV 12404

Query: 1205  VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
              W  +G  +++G+  ++ ++G  R+L I          Y+C+   A  +  L+   + A 
Sbjct: 12405 KWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEA- 12463

Query: 1265  PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQ 1324
                 V     A   V  T    ++LV  +S PG  V WYK  E +   GR ++   G ++
Sbjct: 12464 ----VFTKNLANIEVSETD--TIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKR 12517

Query: 1325  VLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS 1384
             +L +Q A   DAG Y C  P       V V E L  + +S+   L + EG+ A F C +S
Sbjct: 12518 ILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHE-LAAEFISKPQNLEILEGEKAEFVCSIS 12576

Query: 1385  PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHV 1444
                  V W R+   +  G + ++  +G  R+L ++   L D GT  +  G+   +A L V
Sbjct: 12577 KESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV 12636

Query: 1445  RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHI 1504
              E +L  +  L+D R +E Q+V    E    GA    +W R  + +   S+  + Q   +
Sbjct: 12637 IE-KLRIVVPLKDTRVKEQQEVVFNCEVNTEGAKA--KWFRNEEAIFDSSKYIILQKDLV 12693

Query: 1505  HRLFIHGVILADQGTYGCESHHDR-----TLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
             + L I    L DQ  Y     + R     + A L V    LR++ PL+D+   E  S TF
Sbjct: 12694 YTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTF 12753

Query: 1560  QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
               ++++  VT +W + G ++    +     D ++H L +   G  D G    TA   +  
Sbjct: 12754 WCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSV 12813

Query: 1620  ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
             A L++ E P   V    D  VTE D A F C+LS+  A+V W ++G  +    + + +  
Sbjct: 12814 AELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKD 12873

Query: 1680  GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
             G+   L ++ C   D   Y+C V   R    RL V E  V ++   + +    G    F 
Sbjct: 12874 GSIHRLIIKDCRLDDECEYACGV-EDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFL 12932

Query: 1740  CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA 1799
               +++ +   +W      +  G + ++  EGK H L + +++  D GE RF A   ++ A
Sbjct: 12933 AELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARA 12992

Query: 1800  LLEVEALP 1807
              LE+ A P
Sbjct: 12993 KLELAAAP 13000



 Score =  439 bits (1128), Expect = e-122
 Identities = 392/1575 (24%), Positives = 667/1575 (42%), Gaps = 85/1575 (5%)

Query: 327   QTLSAVQ---LHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPC 383
             Q L+A+    L VKE  L F  PL+DV   E   A  EC V        W +    +   
Sbjct: 11469 QALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC-VLTREANVIWSKGPDIIKSS 11527

Query: 384   RKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLD--VL 441
              K++ I +G    L+I+  + DD+G+Y  E+ G+ +T A + V G  LK +    D  V 
Sbjct: 11528 DKFDIIADGKKHILVINDSQFDDEGVYTAEVEGK-KTSARLFVTGIRLKFMSPLEDQTVK 11586

Query: 442   EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFS 498
             EGE A  + E     +   W ++  +L     +  SS G  H L +  VT +D  ++   
Sbjct: 11587 EGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 11646

Query: 499   LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-----IYRL 553
             +    +T  L+V  ++  P     L +     K+ + L  +  +  P   F     I   
Sbjct: 11647 VKELSSTAQLKV--LEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPS 11704

Query: 554   ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
              +  + ++   +   I+KA         +  +G+Y   +C         +V     A L+
Sbjct: 11705 PKYSIKADGLRRILKIKKAD--------LKDKGEY---VCDCGTDKTKANVTVE--ARLI 11751

Query: 614   PTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRI 672
                + + G+E   V+ GE A F ++LS   + G W L G+ L ++ P+ +         I
Sbjct: 11752 KVEKPLYGVE---VFVGETAHFEIELSEPDVHGQWKLKGQPLTAS-PDCE---------I 11798

Query: 673   EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
              + G +H LILH  +   +G  V F     + +A L ++E P+  ++P   V +     +
Sbjct: 11799 IEDGKKHILILHNCQLGMTGE-VSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKD 11855

Query: 733   RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
                  CE+SR      W K  Q++   +   +  DG KH +++  A  +D  ++    E 
Sbjct: 11856 EAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAED 11915

Query: 793   VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDF 852
                   + ++   +  + P + V   A   E  +   E+  ++  V+W+K+ Q +  +  
Sbjct: 11916 KHTSGKLIIEGIRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRS 11973

Query: 853   VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVY-VAAV 911
             V +++EG    +        D  + +  A    +   +T+ +      Y +GK+     V
Sbjct: 11974 VSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDP---YFTGKLQDYTGV 12030

Query: 912   RLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCE 971
               + V+L CE+ +  A V+W KDG+E+  S   +++ +   R L+L      D G+Y C+
Sbjct: 12031 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 12090

Query: 972   IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEE 1031
                +  S  + + +  ++++ P   V ++    E      E+S +D    W   G  + +
Sbjct: 12091 CGTDKTSGKLDIEDREIKLVRPLHSVEVMET--ETARFETEISEDDIHANWKLKGEALLQ 12148

Query: 1032  SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDL 1091
             +    ++ +G    LVL   + +  G     A +  +   + V      ++ P     D+
Sbjct: 12149 TPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLK---DV 12205

Query: 1092  HFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
                A       CE++     V WY  G ++E SD +   +EG   TLTL   + EDAGE 
Sbjct: 12206 TVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEV 12265

Query: 1152  VCETRHEAITFNVILAEPPVQFLALETTP-SPLCVAPGEPVVLSCELSRAGAPVVWSHNG 1210
                 +      N+ + EPPV+F    T P     V  G   VL CE+SR  A V W  NG
Sbjct: 12266 QLTAKDFKTHANLFVKEPPVEF----TKPLEDQTVEEGATAVLECEVSRENAKVKWFKNG 12321

Query: 1211  RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVV 1270
               + + +  E+ A+G  R L I    P     YTC +         S  + V  P V  +
Sbjct: 12322 TEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDF----KTSCNLNVVPPHVEFL 12377

Query: 1271  APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
              P     +VR       E    LS     V+W+KDG  +    +  +   GA ++L +  
Sbjct: 12378 RP-LTDLQVREKEMARFEC--ELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINK 12434

Query: 1331  ARSGDAGEYLCDA--PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA 1388
                 D  EY C+    + S +  V  EE +  K    L  + V E D     CEVS P A
Sbjct: 12435 CLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTK---NLANIEVSETDTIKLVCEVSKPGA 12491

Query: 1389  DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETE 1448
             +V W +    +    + E+   G  RIL ++   L DAG    R  S+ T  ++ V E  
Sbjct: 12492 EVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELA 12551

Query: 1449  LLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLF 1508
               F+ + Q++   EG+         +   +  V+W R  + L    +  +  DG    L 
Sbjct: 12552 AEFISKPQNLEILEGEKAEFVCSISK--ESFPVQWKRDDKTLESGDKYDVIADGKKRVLV 12609

Query: 1509  IHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
             +    L D GTY       R  A L+V  + LR++ PL+D  + E     F  E++ EG 
Sbjct: 12610 VKDATLQDMGTYVVMVGAARAAAHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGA 12668

Query: 1569  TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC--VSFT---ADSLRCAARLI 1623
               +W R    ++   K  I      + L +    L D     VS T    ++++ AA LI
Sbjct: 12669 KAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLI 12728

Query: 1624  VREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRR 1683
             V E  + IV    D+E  E  + TF C++++    + W K+G  +    R+  +    + 
Sbjct: 12729 VEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKH 12788

Query: 1684  LLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVS 1743
             +L ++ CG  D G Y    G  ++    L + E     +  L   +  E D A F C +S
Sbjct: 12789 MLTIKDCGFPDEGEYIVTAGQDKS-VAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLS 12847

Query: 1744  EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEV 1803
               +   +W   GR ++ G + +  ++G  H L++ + R +D  E        +S A L V
Sbjct: 12848 REKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFV 12907

Query: 1804  EALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTH 1863
             E +P+++ R PP++     G   V    +++    V WLR    +  GDK++M S G  H
Sbjct: 12908 EEIPVEIIR-PPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIH 12966

Query: 1864  SLVIHDVRPEDQGTY 1878
              L I D++P DQG Y
Sbjct: 12967 RLQICDIKPRDQGEY 12981



 Score =  394 bits (1013), Expect = e-109
 Identities = 402/1699 (23%), Positives = 685/1699 (40%), Gaps = 129/1699 (7%)

Query: 228   QPPESPPADPDEAPAPVVEPLKCAPKTFWVNE------------GKHAKFRCYVMGKPEP 275
             +P       PDEAP      LK  P  F V E            G  A F C V   P  
Sbjct: 11092 RPGSGGEKPPDEAP--FTYQLKAVPLKF-VKEIKDIILTESEFVGSSAIFECLV--SPST 11146

Query: 276   EIE-WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
              I  W  +G  +    +     D      L ++  Q  D G Y C  R    +  S  +L
Sbjct: 11147 AITTWMKDGSNIRESPKHRFIADGKDR-KLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKL 11205

Query: 335   HVKEPRLRFTRPLQD----VEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
              V+E  +RF + L++    V+G+      L C++ N      W R+D +++   K  +I 
Sbjct: 11206 VVEELPVRFVKTLEEEVTVVKGQP---LYLSCEL-NKERDVVW-RKDGKIV-VEKPGRIV 11259

Query: 391   EGTV---RRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-----GPILKRLPRKLDVLE 442
              G +   R L I+     D G Y   +        +  VK        L +  R   V  
Sbjct: 11260 PGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKP 11319

Query: 443   GENAVLLVETLEAGVEGRWSRDGEELPVICQSSS-----GHMHALVLPGVTREDAGEVTF 497
                A+   +  +     +W +  +E+P      +     G+   L +     ED  E   
Sbjct: 11320 KGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAV 11379

Query: 498   SLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLER-- 555
              +   R                    A++  G +   LL  KP E       IY  E   
Sbjct: 11380 EIEGKRYP------------------AKLTLGEREVELL--KPIEDVT----IYEKESAS 11415

Query: 556   --QEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
                E+   D    + ++       P   + +EG  RF         ++  V++  + + +
Sbjct: 11416 FDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQ-ALNAI 11474

Query: 614   PTARL---------VAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
              TA L            L+DV V +   A F   L+      W    + +KS++      
Sbjct: 11475 TTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTREANVIWSKGPDIIKSSD------ 11528

Query: 665   PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
                 ++ I   G +H L+++  +  D G        G + SA L +    +  +SP +  
Sbjct: 11529 ----KFDIIADGKKHILVINDSQFDDEGVYTA-EVEGKKTSARLFVTGIRLKFMSPLE-- 11581

Query: 725   SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
               T    E     CELS       W+K+  K+  S  +++  +G+ H+L + E  + D  
Sbjct: 11582 DQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDIS 11641

Query: 785   EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH---AITSECVMLACEVDREDAPVRWY 841
             + + + + +S+   + V +      DP   V +H   A+  + + L CEV + D PV+W+
Sbjct: 11642 QIKAQVKELSSTAQLKVLE-----ADPYFTVKLHDKTAVEKDEITLKCEVSK-DVPVKWF 11695

Query: 842   KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
             KDG+E+  S    ++ +G  R L +      D GE+ C  G +     VT   V + ++ 
Sbjct: 11696 KDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVT---VEARLIK 11752

Query: 902   PSGKVYVAAVRL-ERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960
                 +Y   V + E      EL  P    +W   G+ +  SP   + ++     L+L   
Sbjct: 11753 VEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNC 11812

Query: 961   QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV 1020
             QL  +GE   +  +  ++  + V E P+  I P  +V +     +     CE+SRE    
Sbjct: 11813 QLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKDEAKFECEVSREPKTF 11870

Query: 1021  RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
             RW K   E+   +   L +DG +  +V+ +A  ED  +++ +A D      + +     +
Sbjct: 11871 RWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLK 11930

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140
              + P     D+            E++    +V+W+K+   +  + ++ +  EG T ++T 
Sbjct: 11931 FLTPLK---DVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITF 11987

Query: 1141  PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 1200
                  +D  +   E    +    + + E    F               + V+L CE+S+A
Sbjct: 11988 KDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTG---KLQDYTGVEKDEVILQCEISKA 12044

Query: 1201  GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV 1260
              APV W  +G+ ++  +   + A+G +R+L ++ A  +  G YTC      G    S  +
Sbjct: 12045 DAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDC----GTDKTSGKL 12100

Query: 1261  QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA 1320
              + +  +++V P      V  T     E    +S       W   GE L      ++++ 
Sbjct: 12101 DIEDREIKLVRP-LHSVEVMETETARFE--TEISEDDIHANWKLKGEALLQTPDCEIKEE 12157

Query: 1321  GARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
             G    L +   R    G     A        + V +P ++ L+  L  +TV  G+ ATF 
Sbjct: 12158 GKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRV-KPRVIGLLRPLKDVTVTAGETATFD 12216

Query: 1381  CEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA 1440
             CE+S  D  V W   G  + P  +V     G    LTLR  +L DAG V L A    T A
Sbjct: 12217 CELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHA 12276

Query: 1441  RLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQ 1500
              L V+E  + F + L+D   EEG    LE E  R  A   V+W + G  +    +  +  
Sbjct: 12277 NLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA--KVKWFKNGTEILKSKKYEIVA 12334

Query: 1501  DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ 1560
             DG + +L IH     D  TY C++   +T   L+V P  +  LRPL D+ + E   A F+
Sbjct: 12335 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFE 12394

Query: 1561  LELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAA 1620
              ELS+E    +W + G ++  G K  I S G    LV+N   L D    S    + R + 
Sbjct: 12395 CELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSG 12454

Query: 1621  RLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALG 1680
              L V E      +   ++EV+E DT    CE+S+  A+V W K    +  + R  +   G
Sbjct: 12455 MLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEG 12514

Query: 1681  TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC 1740
              +R+L ++     DAG Y+C + ++R    ++ V E     +S+ +++   EG+ A F C
Sbjct: 12515 RKRILVIQNAHLEDAGNYNCRLPSSRTDG-KVKVHELAAEFISKPQNLEILEGEKAEFVC 12573

Query: 1741  TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA- 1799
             ++S+     +W+   + L  G +  +  +GKK +LV+ +   +D G      G A++ A 
Sbjct: 12574 SISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAH 12633

Query: 1800  LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSH 1859
             L  +E L + +   P ++  V   +  V    V+  G    W R    +    KY +   
Sbjct: 12634 LTVIEKLRIVV---PLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQK 12690

Query: 1860  GPTHSLVIHDVRPEDQGTY 1878
                ++L I D   +DQ  Y
Sbjct: 12691 DLVYTLRIRDAHLDDQANY 12709



 Score =  385 bits (988), Expect = e-106
 Identities = 420/1813 (23%), Positives = 709/1813 (39%), Gaps = 111/1813 (6%)

Query: 105   PASDPELQPAERP-------LPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
             P S  E  P E P       +P     E   + LT   S++V  G+  +  C        
Sbjct: 11093 PGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILT--ESEFV--GSSAIFECLVSPSTAI 11148

Query: 158   TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
             T  W KDG  + E          P       G    L I+  +L D+G Y C  R  +  
Sbjct: 11149 TT-WMKDGSNIRE---------SPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKE 11198

Query: 218   AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
               + A L V + P              V  +K   +   V +G+     C +    E ++
Sbjct: 11199 KTSTAKLVVEELP--------------VRFVKTLEEEVTVVKGQPLYLSCEL--NKERDV 11242

Query: 278   EWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
              W  +G+ ++    R++         L +      D G Y     N+     S+    V+
Sbjct: 11243 VWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVE 11302

Query: 338   EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFR--EDQRLLPCRKYEQIEEGTVR 395
               R    +P++D   +  G A+  C +        WF+  ++    P  K E + +G   
Sbjct: 11303 VIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHL 11362

Query: 396   RLIIHRLKADDDGIYLCEMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVET 452
              L I     +D   Y  E+ G+ R  A +T+   +  +LK +   + + E E+A    E 
Sbjct: 11363 YLKIKNAMPEDIAEYAVEIEGK-RYPAKLTLGEREVELLKPI-EDVTIYEKESASFDAEI 11420

Query: 453   LEAGVEGRWSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLR 509
              EA + G+W   GE L   P     + G    L L  V  + AGEV +   N+ TT +L 
Sbjct: 11421 SEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILT 11480

Query: 510   VKCVK--HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCF 567
             VK ++   + P   +     +  +   +LT        E   I+      + S D     
Sbjct: 11481 VKEIELDFAVPLKDVTVPERRQARFECVLT-------REANVIWSKGPDIIKSSDKFDII 11533

Query: 568   SIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQV 627
             +  K   + +       EG Y      V G   S  +   G        + ++ LED  V
Sbjct: 11534 ADGKKHILVINDSQFDDEGVYT---AEVEGKKTSARLFVTGIR-----LKFMSPLEDQTV 11585

Query: 628   YDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
              +GE A F  +LS   +   WF N  +L ++              I  +G  H+L +  V
Sbjct: 11586 KEGETATFVCELSHEKMHVVWFKNDAKLHTSRT----------VLISSEGKTHKLEMKEV 11635

Query: 687   KHQDSGALVGFSCPGVQDSAALTIQES-PVHILSPQDRVSLTFTTSERVVLTCELSRVDF 745
                D   +       +  +A L + E+ P   +   D+   T    + + L CE+S+ D 
Sbjct: 11636 TLDDISQIKA-QVKELSSTAQLKVLEADPYFTVKLHDK---TAVEKDEITLKCEVSK-DV 11690

Query: 746   PATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPP 805
             P  W+KDG+++  S    +K DG +  L + +A ++D GE+ C          VTV+   
Sbjct: 11691 PVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARL 11750

Query: 806   VHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLV 865
             + +  P   V V     E      E+   D   +W   GQ +  S    +  +G    L+
Sbjct: 11751 IKVEKPLYGVEV--FVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILI 11808

Query: 866   LPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRP 925
             L   Q    GE    A +  +   + + ++    + P   V V     +     CE+ R 
Sbjct: 11809 LHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKV--FEKDEAKFECEVSRE 11866

Query: 926   WAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTE 985
                 RW K  +E+       L K+ T   +V+ +   ED  +Y+ E +D+  S  + +  
Sbjct: 11867 PKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEG 11926

Query: 986   PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCR 1045
               ++ + P  +VT  A   E  V   ELS ++  V+W+K+   +  + ++ ++ +G    
Sbjct: 11927 IRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 11984

Query: 1046  LVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEV 1105
             +       +D  +   +A   S+   +TV    E   +   +  D        V L+CE+
Sbjct: 11985 ITFKDLSIDDTSQIRVEAMGMSSEAKLTVL---EGDPYFTGKLQDYTGVEKDEVILQCEI 12041

Query: 1106  APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVI 1165
             + A + V+W+KDG E++ S    + A+G  R L L  A   D G+Y C+   +  +  + 
Sbjct: 12042 SKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLD 12101

Query: 1166  LAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEG 1225
             + +  ++   L      + V   E      E+S       W   G  + +    E+  EG
Sbjct: 12102 IEDREIK---LVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEG 12158

Query: 1226  PRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGG 1285
                 L +        G      G    A ++  +  +   P RV+        V  T G 
Sbjct: 12159 KIHSLVLHNCRLDQTG------GVDFQAANVKSSAHLRVKP-RVIGLLRPLKDVTVTAGE 12211

Query: 1286  DLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQ 1345
                    LS    PV WY  G++L    +V     G    L ++  +  DAGE    A  
Sbjct: 12212 TATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD 12271

Query: 1346  DSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQV 1405
                   + V+EP  V+    L   TV EG  A   CEVS  +A V W +NG  +    + 
Sbjct: 12272 FKTHANLFVKEPP-VEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKY 12330

Query: 1406  EMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQD 1465
             E+  +G  R L +  C   D  T T  A    TS  L+V    + FLR L D++  E + 
Sbjct: 12331 EIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEM 12390

Query: 1466  VCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESH 1525
                E E  R  A   V+W + G  +    +  +   G +  L I+  +L D+  Y CE  
Sbjct: 12391 ARFECELSRENAK--VKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR 12448

Query: 1526  HDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKC 1585
               RT   L+V   +    + L ++ +SE  +     E+S+ G    W +G  ++    + 
Sbjct: 12449 TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRY 12508

Query: 1586  HIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT 1645
              I ++G +  LV+    L D+G  +    S R   ++ V E+    +  P +LE+ EG+ 
Sbjct: 12509 EILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEK 12568

Query: 1646  ATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTA 1705
             A F C +S+    V W++D   L    +  + A G +R+L ++     D GTY   VG A
Sbjct: 12569 AEFVCSISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAA 12628

Query: 1706  RAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVR 1765
             RA    LTV E+ + ++  L+    +E     F C V+      +W      +   ++  
Sbjct: 12629 RAA-AHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYI 12686

Query: 1766  IRQEGKKHILVLSELRAEDAGE-----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTV 1820
             I Q+   + L + +   +D           +    +S A L VE   L++   P ++   
Sbjct: 12687 ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIV-EPLKDIET 12745

Query: 1821  LVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC 1880
             +  +       V+R    + W + G E+   ++   R     H L I D    D+G Y  
Sbjct: 12746 MEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIV 12805

Query: 1881  QAGQDSTHTRLLV 1893
              AGQD +   LL+
Sbjct: 12806 TAGQDKSVAELLI 12818



 Score =  380 bits (975), Expect = e-105
 Identities = 317/1277 (24%), Positives = 523/1277 (40%), Gaps = 41/1277 (3%)

Query: 622   LEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRL 681
             L D    + ++     ++S  +   WF +GEE+  +           +Y I+  GL+  L
Sbjct: 11669 LHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSP----------KYSIKADGLRRIL 11718

Query: 682   ILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELS 741
              +     +D G  V   C   +  A +T++   + +  P   V +     E      ELS
Sbjct: 11719 KIKKADLKDKGEYV-CDCGTDKTKANVTVEARLIKVEKPLYGVEVF--VGETAHFEIELS 11775

Query: 742   RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTV 801
               D    W   GQ +  S    +  DG+KH LIL   ++  +GE   +     +   + V
Sbjct: 11776 EPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKV 11835

Query: 802   QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPH 861
             ++ P+  + P   V V     +     CEV RE    RW K  QE+   D   L  +G  
Sbjct: 11836 KELPLIFITPLSDVKV--FEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTK 11893

Query: 862   RRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCE 921
               +V+ +    D  ++   A D+     + I  +    + P   V   A   E  V T E
Sbjct: 11894 HSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDV--TAKEKESAVFTVE 11951

Query: 922   LCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTV 981
             L      V+W K+ + +  + ++ +Q E     +    + ++D+ +   E    S+   +
Sbjct: 11952 LSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 12011

Query: 982   TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
             TV E          + T   V  + V+L CE+S+ DAPV+W+KDG E++ S+  V++ DG
Sbjct: 12012 TVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADG 12069

Query: 1042  PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
              +  L+L  A   D G++ CD G D     + +     ++V P   S+++      R E 
Sbjct: 12070 KKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPL-HSVEVMETETARFET 12128

Query: 1102  RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
               E++       W   G  +  +   ++  EG   +L L + + +  G    +  +   +
Sbjct: 12129 --EISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSS 12186

Query: 1162  FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLEL 1221
              + +  +P V  + L      + V  GE     CELS    PV W   G+ ++  + +  
Sbjct: 12187 AH-LRVKPRV--IGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVP 12243

Query: 1222  HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRS 1281
              +EG    L ++      AG     +       +L     V EPPV    P   QT    
Sbjct: 12244 RSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----VKEPPVEFTKPLEDQT---V 12296

Query: 1282  TPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
               G    L   +S     V+W+K+G  +    + ++   G  + L +      D   Y C
Sbjct: 12297 EEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC 12356

Query: 1342  DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP 1401
             DA        ++V  P  V+ +  LT L V E + A F CE+S  +A V W ++GA +  
Sbjct: 12357 DAKDFKTSCNLNVVPPH-VEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKK 12415

Query: 1402  GPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAE 1461
             G + ++   G+ RIL +  C L D    +    +  TS  L V E E +F + L ++   
Sbjct: 12416 GKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVS 12475

Query: 1462  EGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYG 1521
             E   + L  E  + GA   V W +G + +    R  +  +G    L I    L D G Y 
Sbjct: 12476 ETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYN 12533

Query: 1522  CESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
             C     RT  ++ V       +   +++ I EG  A F   +S+E    +W R    L  
Sbjct: 12534 CRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLES 12593

Query: 1582  GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
             G K  + +DG +  LV+    L D G       + R AA L V E  + IV    D  V 
Sbjct: 12594 GDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK 12652

Query: 1642  EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA 1701
             E     F CE++   A   W ++  A+  S +  +        L++R     D   Y+ +
Sbjct: 12653 EQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVS 12712

Query: 1702  VGTARAGPVR----LTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRP 1757
             +   R   V+    L V E  + ++  L+ +   E    TF C V+ +  T +W   G  
Sbjct: 12713 LTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEE 12772

Query: 1758  LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
             +    RV  R +  KH+L + +    D GE    AG  +S+A L +   P +   H   +
Sbjct: 12773 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHL-ED 12831

Query: 1818  KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
             +TV     AV    +SR   +V W R G E+  G KY+    G  H L+I D R +D+  
Sbjct: 12832 QTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECE 12891

Query: 1878  YCCQAGQDSTHTRLLVE 1894
             Y C      +  RL VE
Sbjct: 12892 YACGVEDRKSRARLFVE 12908



 Score =  333 bits (855), Expect = 7e-91
 Identities = 462/1993 (23%), Positives = 771/1993 (38%), Gaps = 236/1993 (11%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            +PP F + P PV  + G++  L+C + G PP  VVW K  +Q+  S++    +   +  L
Sbjct: 6456 APPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSL 6515

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
             +     +D G Y C+A N  G    + +V   EPP    +L                  
Sbjct: 6516 HILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTS-------------- 6561

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
                      L G  V L     G    ++ W KD   +    +++  +     A     
Sbjct: 6562 ---------TLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIA----- 6607

Query: 190  ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLK 249
                L++ +    +SG Y+C  +N  G  +  A+L V +P            A ++E   
Sbjct: 6608 ---TLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEP------------ARIIEK-- 6650

Query: 250  CAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPD-RRRLMYRDRDGGFVLKVLY 308
              P+   V  G      C V G PE   +W  +GR L  D +  + + ++     LK+  
Sbjct: 6651 --PEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVAS--LKIPC 6706

Query: 309  CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRL--RFTRPLQDVEGREHGIAVLECKVPN 366
             +  D+GLY    +NS G++   V +HV +  +   F R L+DV        VLEC+V  
Sbjct: 6707 AEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSG 6766

Query: 367  SR-IPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVA 422
            S  I   WF++   ++   K +      V  L +  L+  D GIY C    + G     A
Sbjct: 6767 SAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSA 6826

Query: 423  NVTVKGP-ILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDGEELPV--ICQ 473
             +TV+ P   ++ P  ++VL G +      T  + + G      +W +   EL     C 
Sbjct: 6827 VLTVQEPPSFEQTPDSVEVLPGMSL-----TFTSVIRGTPPFKVKWFKGSRELVPGESCN 6881

Query: 474  SS-SGHMHALVLPGVTREDAGE----VTFSLGNSRTTTLLRVK----CVKHSPP-----G 519
             S    +  L L  V   ++G+    VT   G++  TT L VK     VK         G
Sbjct: 6882 ISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETG 6941

Query: 520  PPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPG 579
             PI+ E        + ++W   E        Y + + E  S         EK+  +E+  
Sbjct: 6942 SPIVLEATYTGTPPISVSWIKDE--------YLISQSERCS-----ITMTEKSTILEILE 6988

Query: 580  DCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFS--L 637
              +     Y   I   +G       +      ++     +  LE V+   GE A     +
Sbjct: 6989 STIEDYAQYSCLIENEAGQD-----ICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKV 7043

Query: 638  DLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGF 697
            D +  I+ +W+    +L+S          A  Y+++ K     L+++ V H D G    +
Sbjct: 7044 DGTPEIRISWYKEHTKLRS----------APAYKMQFKNNVASLVINKVDHSDVGE---Y 7090

Query: 698  SCPG------VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD-FPATWY 750
            SC        V  SA L I+   +     +    +  T    V   C ++  +    +WY
Sbjct: 7091 SCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWY 7150

Query: 751  KDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECR------TEGVSAFFGVTVQD- 803
            KDG  +++   L          L + +      G++ C       T   SA   ++  + 
Sbjct: 7151 KDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEV 7210

Query: 804  PPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR--WYKDGQEVEESD---FVVLENE 858
            PP   + P   V V     E     C V    AP++  W KD +E+         ++EN 
Sbjct: 7211 PPFFDLKP---VSVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGGNYKMTLVENT 7266

Query: 859  GPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVL 918
                 L +      D G++ C A +            S+ +       ++  +   R+V 
Sbjct: 7267 AT---LTVLKVGKGDAGQYTCYASNIAGK-----DSCSAQLGVQEPPRFIKKLEPSRIVK 7318

Query: 919  TCELCR--------PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC 970
              E  R        P  +V W KD  E+ ES    +   D+V  L +  + +EDSG+Y C
Sbjct: 7319 QDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTC 7378

Query: 971  EIDDE----SASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDA-PVRWYKD 1025
            E  +     S+S ++ V EPP+    P    TL    +    L CEL       V WYKD
Sbjct: 7379 EAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVH---LECELQGTPPFHVSWYKD 7435

Query: 1026 GLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERI 1081
              E+   +   +  +     + +      D GE+ C    D G D+   ++ + APP  +
Sbjct: 7436 KRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFV 7495

Query: 1082 VHPAARSLDLHFGAPGRVELRCEVAPAGS-QVRWYKD-GLEVEASDALQLGAEGPTRTLT 1139
                 +  D+       V+L+  +  A    V W+KD G  V  SD + +       TL 
Sbjct: 7496 ----KKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQ 7551

Query: 1140 LPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSR 1199
                +P +AG+Y C+ +++A           ++   +   P  + V  G+   L C +  
Sbjct: 7552 FSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTV-- 7609

Query: 1200 AGAPVV---WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSL 1256
            AG P +   W  +G+ +      ++        L I    P+ +G+Y+ +     G  S 
Sbjct: 7610 AGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSC 7669

Query: 1257 SFTVQVAEPPVRVVAPEAAQTRVRSTPG-GDLELVVHLSGPGGP---VRWYKDGERLASQ 1312
            + ++QV++  V    P +   +++ T G     +V+     G P   V W+ +G  ++S 
Sbjct: 7670 TASLQVSDRTV----PPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSG 7725

Query: 1313 GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQ----DSRIFLVSVEEPLLVKLVSELTP 1368
             + Q         L V      D+G+Y C A      D     ++V EP     V +  P
Sbjct: 7726 RKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREP--PSFVQKPDP 7783

Query: 1369 LTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAG 1427
            + V  G + TF   V   P   V+W +  + + PG +  ++   S   L L       +G
Sbjct: 7784 MDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSG 7843

Query: 1428 TVTL----RAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLE-VETGRVGAAGAVR 1482
              T      AG  + +  L+++     F++RL D   E+G+ + LE   TG    +  V 
Sbjct: 7844 EYTCIVSNEAGKASCTTHLYIK-APAKFVKRLNDYSIEKGKPLILEGTFTGTPPIS--VT 7900

Query: 1483 WVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRV 1542
            W + G  +    R ++        L I    + D G Y C   +       S    Q+ +
Sbjct: 7901 WKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSA---QILI 7957

Query: 1543 LRP------LEDVTISEGGSATFQLELSQEGVTG-EWARGGVQLYPGPKCHIHSDGHRHR 1595
            L P      LE V +S G SA+ Q +L+     G  W +G  +L P     +H   +   
Sbjct: 7958 LEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVAT 8017

Query: 1596 LVLNGLGLADSGCVSFTADS----LRCAARLIVRE--VPVTIVRGPHDLEVTEGDTATFE 1649
            LV N + + DSG     A++    +  +  L V+E  +P +  R   D++ T G    F+
Sbjct: 8018 LVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFD 8077

Query: 1650 CELSQALA-DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGT 1704
            C +S +    V+W KDG  L  SP ++   L     L + +   S AG YSC     +G+
Sbjct: 8078 CAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGS 8137

Query: 1705 ARAGPVRLTVRERTVAVLSELR--SVSAREGDGATFECTVSEVETTG-RWELGGRPLRPG 1761
            A +   RL + E       ++R   V A  G+ A FEC V+  +     W    R +R G
Sbjct: 8138 ASSS-ARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSG 8196

Query: 1762 ARVRIRQ-EGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVEA--LPLQMCRHP 1814
             + +I   E   H+ VL ++   D+G+    A    G     A L ++   +P    +  
Sbjct: 8197 GKYQISYLENSAHLTVL-KVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRL 8255

Query: 1815 PREKTVLVGRRAVLEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE 1873
                    G    LE  V+ S    V W +   E+ P    E+     T  L +      
Sbjct: 8256 SETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMN 8315

Query: 1874 DQGTYCCQAGQDS 1886
            D G Y C+   D+
Sbjct: 8316 DAGLYTCKVSNDA 8328



 Score =  327 bits (837), Expect = 9e-89
 Identities = 255/852 (29%), Positives = 387/852 (45%), Gaps = 25/852 (2%)

Query: 1052  QPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL-RCEVAPAGS 1110
             +P  GGE       D A FT  + A P + V      +       G   +  C V+P+ +
Sbjct: 11092 RPGSGGE----KPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTA 11147

Query: 1111  QVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR----HEAITFNVIL 1166
                W KDG  +  S   +  A+G  R L +   Q  DAGEY C  R     +  T  +++
Sbjct: 11148 ITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVV 11207

Query: 1167  AEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAE-G 1225
              E PV+F+  +T    + V  G+P+ LSCEL++    VVW  +G+ V E  G  +    G
Sbjct: 11208 EELPVRFV--KTLEEEVTVVKGQPLYLSCELNKE-RDVVWRKDGKIVVEKPGRIVPGVIG 11264

Query: 1226  PRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGG 1285
               R L I  A    AG YT     A      S  V+V E     +        V+  P G
Sbjct: 11265 LMRALTINDADDTDAGTYTVTVENANNL-ECSSCVKVVEVIRDWLVKPIRDQHVK--PKG 11321

Query: 1286  DLELVVHLSGPGGPVRWYKDGERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDA 1343
                    ++     ++W+K  + + ++   + ++ + G    L+++ A   D  EY  + 
Sbjct: 11322 TAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEI 11381

Query: 1344  PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGP 1403
                     +++ E   V+L+  +  +T++E + A+F  E+S  D    W   G ++ P P
Sbjct: 11382 EGKRYPAKLTLGERE-VELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRPSP 11440

Query: 1404  QVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEG 1463
               E+   G  R LTL   +L  AG V  +A +  T+A L V+E EL F   L+DV   E 
Sbjct: 11441 TCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPER 11500

Query: 1464  QDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCE 1523
             +    E    R      V W +G   +    +  +  DG  H L I+     D+G Y  E
Sbjct: 11501 RQARFECVLTR---EANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAE 11557

Query: 1524  SHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGP 1583
                 +T ARL V   +L+ + PLED T+ EG +ATF  ELS E +   W +   +L+   
Sbjct: 11558 VEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSR 11617

Query: 1584  KCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEG 1643
                I S+G  H+L +  + L D   +      L   A+L V E         HD    E 
Sbjct: 11618 TVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEK 11677

Query: 1644  DTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVG 1703
             D  T +CE+S+ +  V W KDG  + PSP+  ++A G RR+L++++    D G Y C  G
Sbjct: 11678 DEITLKCEVSKDVP-VKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCG 11736

Query: 1704  TARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGAR 1763
             T +     +TV  R + V   L  V    G+ A FE  +SE +  G+W+L G+PL     
Sbjct: 11737 TDKT-KANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPD 11795

Query: 1764  VRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVG 1823
               I ++GKKHIL+L   +    GEV FQA  A+S A L+V+ LPL     P  +  V   
Sbjct: 11796 CEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFIT-PLSDVKVFEK 11854

Query: 1824  RRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAG 1883
               A  E  VSR      WL+   E+   D++E+   G  HS+VI     ED+  Y  +A 
Sbjct: 11855 DEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAE 11914

Query: 1884  QDSTHTRLLVEG 1895
                T  +L++EG
Sbjct: 11915 DKHTSGKLIIEG 11926



 Score =  322 bits (825), Expect = 2e-87
 Identities = 449/1979 (22%), Positives = 756/1979 (38%), Gaps = 205/1979 (10%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP F+     V  V G  A L+C V G P   + W K   +L ++             L+
Sbjct: 7019 PPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLV 7078

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +     +D G Y C+A N+ G A A++AV V++            R LP        P F
Sbjct: 7079 INKVDHSDVGEYSCKADNSVG-AVASSAVLVIKA-----------RKLP--------PFF 7118

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
                +      G  V   CR  G     + W KDG+ L +  D++   LQ     +    
Sbjct: 7119 ARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKD--DAN---LQTSFVHN---- 7169

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
               L+IL       G Y C A N  G A + A L + +  E PP   D  P  V   L  
Sbjct: 7170 VATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEH-EVPPFF-DLKPVSVDLAL-- 7225

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
                     G+   F+C+V G    +I W  + R + P     M    +    L VL   
Sbjct: 7226 ---------GESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTA-TLTVLKVG 7275

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVE-GREHGIAVLECKVPNS-R 368
              D G Y C A N AG+   + QL V+EP  RF + L+     ++      ECK+  S  
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEPP-RFIKKLEPSRIVKQDEFTRYECKIGGSPE 7334

Query: 369  IPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV-- 426
            I   W++++  +    K+      +V  L +H L  +D G Y CE      + ++ T   
Sbjct: 7335 IKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLK 7394

Query: 427  --KGPILKRLPRKLDVLEGENAVLLVET-------LEAGVEGRWSRDGEELPVICQSSSG 477
              + PI ++ P  ++ L+G +  L  E        +    + R  R G++  ++ ++   
Sbjct: 7395 VKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLT 7454

Query: 478  HMHALVLPGVTREDAGEVTFSLGNS-RTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLL 536
             +H L    V   D GE      N   + T +    +K  P     L+++       V L
Sbjct: 7455 SIHIL---NVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQL 7511

Query: 537  TWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS 596
                    P +   ++ + + V   D I     E    ++       + G Y  +I   +
Sbjct: 7512 QTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDA 7571

Query: 597  GHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI--IQGTWFLNGEEL 654
            G           +  ++  A +V   E ++V  G+       ++    +   WF +G+EL
Sbjct: 7572 GMQEC-----FATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKEL 7626

Query: 655  KSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGAL-VGFSCPGVQDSAALTIQES 713
             S+           +Y+I        L +  V   DSG        P  +DS   ++Q S
Sbjct: 7627 TSDN----------KYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVS 7676

Query: 714  PVHILSPQDRVSLTFT---TSERVVLTCEL-SRVDFPATWYKDGQKVEESELLVVKMDGR 769
                + P     L  T   +   VV+ C++        +W+ +G ++         +   
Sbjct: 7677 D-RTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDN 7735

Query: 770  KHRLILPEAKVQDSGEFECRTEGVSAF----FGVTVQDPPVHIVDPREHVFVHAITSECV 825
               L +   +  DSG++ C    ++        +TV++PP  +  P     +  +T   V
Sbjct: 7736 TCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDP---MDVLTGTNV 7792

Query: 826  MLACEVDREDA-PVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDE 884
                 V       V W+K   E+   D   +  E     L L     S  GE+ C+  +E
Sbjct: 7793 TFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNE 7852

Query: 885  CAYFTVTITDVSSWIVYPSGKV-----YVAAVRLERVVLTCELCRPWAEVRWTKDGEEVV 939
                + T      +I  P+  V     Y        ++       P   V W K+G  V 
Sbjct: 7853 AGKASCT---THLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVT 7909

Query: 940  ESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD----ESASFTVTVTEPPVRIIYPRD 995
             S    +   +    L +P+  +ED+G+Y C I++    +S S  + + EPP    Y   
Sbjct: 7910 PSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPP----YFVK 7965

Query: 996  EVTLIAVTL-ECVVLMCELS-REDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQP 1053
            ++  + V++ +   L C+L+   +  V WYK   ++  +    +        LV      
Sbjct: 7966 QLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDI 8025

Query: 1054 EDGGEFVCDAGDD------SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAP 1107
             D GE++C A +       S F TV     P        R +    G P  V   C ++ 
Sbjct: 8026 NDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQL-RDVQETVGLP--VVFDCAIS- 8081

Query: 1108 AGSQ---VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHE----AI 1160
             GS+   V WYKDG  ++ S  +Q      T TL +       AG+Y C   +     + 
Sbjct: 8082 -GSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASS 8140

Query: 1161 TFNVILAE---PPVQFLALETTPSPLCVAPGEPVVLSCELSRAGA-PVVWSHNGRPVQEG 1216
            +  +IL E   PP   + L    +P+    GE     C ++      V W+ + R ++ G
Sbjct: 8141 SARLILTEGKNPPFFDIRL----APVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSG 8196

Query: 1217 EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQ 1276
               ++        L +       +G YTC +    G  S +  + + E  +     +   
Sbjct: 8197 GKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLS 8256

Query: 1277 TRVRSTPGGDLELVVHLSGPGG-PVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGD 1335
              V  T G   +L   ++G     V WYK+   +      ++       VL+V+ A   D
Sbjct: 8257 ETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMND 8316

Query: 1336 AGEYLCDAPQDSRIFL----VSVEEPLLVKLVSE-LTPLTVHEGDDATFRCEVSPPDA-D 1389
            AG Y C    D+   L    + ++EP    +  + LTP+TV EG+     C V   +   
Sbjct: 8317 AGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIR 8376

Query: 1390 VTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVR 1445
            + WL+ G  + P  +   +    + +L LR     D+G    +A    GS  T +++ ++
Sbjct: 8377 IQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIK 8436

Query: 1446 ET--------------ELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGG-QPL 1490
            +                L F+   Q +R  E        + G       V+W +G  + L
Sbjct: 8437 DKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPN-VKWTKGKWRQL 8495

Query: 1491 PHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSV------RPRQLRV-- 1542
                R+ + Q G   +L I      D G Y C + ++      +V      R +Q ++  
Sbjct: 8496 NQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEG 8555

Query: 1543 -LRPLEDVT--ISEGGSATFQLELSQ----------------EGVTGEWARGGVQLYPGP 1583
             LR +   T  + +G     ++++ +                 G+T    RG +Q +   
Sbjct: 8556 DLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKYARMYGITD--FRGLLQAFELL 8613

Query: 1584 KCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEG 1643
            K     +   HRL +  +  ++     F         RL   E PVT+++   +  V + 
Sbjct: 8614 KQS--QEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTE-PVTLIKDIENQTVLKD 8670

Query: 1644 DTATFECELSQALADV--TWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA 1701
            + A FE ++     ++  +W K    L PS +  +   G R  L+++ C   D G Y   
Sbjct: 8671 NDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLV 8730

Query: 1702 VGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPG 1761
             G   A   +LTV E   A    L+ V+ +EG   T  C  S       W   GR L+P 
Sbjct: 8731 CGPHIAS-AKLTVIEP--AWERHLQDVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQ 8787

Query: 1762 ARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVL 1821
             R +   E K H L ++++RAED G+   +    ++ A L +EA P+Q  +   R + ++
Sbjct: 8788 GRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTK---RIQNIV 8844

Query: 1822 VG--RRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
            V   + A  E  VS     V W +   EL    KY  R+ G  H + IH+V P+D+G Y
Sbjct: 8845 VSEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVY 8903



 Score =  315 bits (807), Expect = 3e-85
 Identities = 253/996 (25%), Positives = 429/996 (43%), Gaps = 47/996 (4%)

Query: 917   VLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI---- 972
             +  C +    A   W KDG  + ESP      +   R+L +  VQL D+GEY C +    
Sbjct: 11137 IFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGN 11196

Query: 973   DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDG-LEVEE 1031
              +++++  + V E PVR +   +E   + V  + + L CEL++E   V W KDG + VE+
Sbjct: 11197 KEKTSTAKLVVEELPVRFVKTLEEEVTV-VKGQPLYLSCELNKE-RDVVWRKDGKIVVEK 11254

Query: 1032  SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGD----DSAFFTVTVTAPPERIVHPAAR 1087
                +V    G    L +  A   D G +     +    + +     V    + +V P   
Sbjct: 11255 PGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIR- 11313

Query: 1088  SLDLHFGAPGRVELRCEVAPAGSQVRWYK--DGLEVEASDALQLGAEGPTRTLTLPHAQP 1145
               D H    G     C++A     ++W+K  D +  E +D  ++  +G    L + +A P
Sbjct: 11314 --DQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMP 11371

Query: 1146  EDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV 1205
             ED  EY  E   +     + L E  V+ L        + +   E      E+S A  P  
Sbjct: 11372 EDIAEYAVEIEGKRYPAKLTLGEREVELL---KPIEDVTIYEKESASFDAEISEADIPGQ 11428

Query: 1206  WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG--LYTCQSGAAPGAPSL-SFTVQV 1262
             W   G  ++     E+ AEG +R L +       AG  LY   +       ++    +  
Sbjct: 11429 WKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDF 11488

Query: 1263  AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
             A P   V  PE  Q R       +  ++           W K  + + S  +  +   G 
Sbjct: 11489 AVPLKDVTVPERRQARFECVLTREANVI-----------WSKGPDIIKSSDKFDIIADGK 11537

Query: 1323  RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
             + +L +  ++  D G Y  +       +R+F+  +     +K +S L   TV EG+ ATF
Sbjct: 11538 KHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGETATF 11593

Query: 1380  RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATS 1439
              CE+S     V W +N A +     V ++  G +  L ++   L D   +  +    +++
Sbjct: 11594 VCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSST 11653

Query: 1440  ARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMA 1499
             A+L V E +  F  +L D  A E  ++ L+ E   V     V+W + G+ +    + S+ 
Sbjct: 11654 AQLKVLEADPYFTVKLHDKTAVEKDEITLKCE---VSKDVPVKWFKDGEEIVPSPKYSIK 11710

Query: 1500  QDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
              DG    L I    L D+G Y C+   D+T A ++V  R ++V +PL  V +  G +A F
Sbjct: 11711 ADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHF 11770

Query: 1560  QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
             ++ELS+  V G+W   G  L   P C I  DG +H L+L+   L  +G VSF A + + A
Sbjct: 11771 EIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA 11830

Query: 1620  ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
             A L V+E+P+  +    D++V E D A FECE+S+      W K    +T   R  L   
Sbjct: 11831 ANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKD 11890

Query: 1680  GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
             GT+  + ++     D   Y            +L +    +  L+ L+ V+A+E + A F 
Sbjct: 11891 GTKHSMVIKSAAFEDEAKYMFEAEDKHTSG-KLIIEGIRLKFLTPLKDVTAKEKESAVFT 11949

Query: 1740  CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA-GPAQSL 1798
               +S      +W    + L     V ++ EGK H +   +L  +D  ++R +A G +   
Sbjct: 11950 VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 12009

Query: 1799  ALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRS 1858
              L  +E  P    +   ++ T +     +L+  +S++   V W ++G E+ P     +++
Sbjct: 12010 KLTVLEGDPYFTGK--LQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKA 12067

Query: 1859  HGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
              G    L++      D G Y C  G D T  +L +E
Sbjct: 12068 DGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIE 12103



 Score =  310 bits (794), Expect = 9e-84
 Identities = 404/1760 (22%), Positives = 689/1760 (39%), Gaps = 205/1760 (11%)

Query: 233  PPADPDEAPAPVVEPLKCAPKTF------WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            P   PD+     + P   APK F       V +G  A FR  V+GKP+PE EW+  G  +
Sbjct: 2062 PTFKPDKIE---LSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI 2118

Query: 287  LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRL-RFTR 345
                R   Y   D    L +    A+D    +  A N AG+T S   L V+  +L  FT+
Sbjct: 2119 ERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2178

Query: 346  PLQDVEGREHG-IAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKA 404
             LQDV  +E   +A  EC+     +   W+++   +    KY    +  V  L I  +  
Sbjct: 2179 ELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDT 2238

Query: 405  DDDGIYLCEM--RGRVRTVANVTVKGPILKRLP--RKLDVLEGENAVLLVETLEAGVEGR 460
             D   Y C +     V+T A + V+G +++ +   + ++V E  +  L        +EG+
Sbjct: 2239 SDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGK 2298

Query: 461  WSRDGEEL----PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
            W  +  EL         S  G  + L +  VT+ED GE +F +   +TT  L++K     
Sbjct: 2299 WYHNDVELKSNGKYTITSRRGRQN-LTVKDVTKEDQGEYSFVIDGKKTTCKLKMK----- 2352

Query: 517  PPGPPILAEMFKGHK----NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKA 572
             P P  + +     K    + V L  K    + E   ++  + QEV   D +     +++
Sbjct: 2353 -PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEG--VWMKDGQEVQPSDRVHIVIDKQS 2409

Query: 573  GAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGED 632
              + +        G+Y F I  + G   S  V  +    + P       L+DV V +G  
Sbjct: 2410 HMLLIEDMTKEDAGNYSFTIPAL-GLSTSGRVSVYSVDVITP-------LKDVNVIEGTK 2461

Query: 633  AVFSLDLST--IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQD 690
            AV    +S   +    W+LN E++K ++          R +   KG + RL+++     D
Sbjct: 2462 AVLECKVSVPDVTSVKWYLNDEQIKPDD----------RVQAIVKGTKQRLVINRTHASD 2511

Query: 691  SG---ALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA 747
             G    +VG     V+ +  L++++  + I   +D   LT T ++ VV   ELS      
Sbjct: 2512 EGPYKLIVG----RVETNCNLSVEKIKI-IRGLRD---LTCTETQNVVFEVELSHSGIDV 2563

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF-----ECRTEGVSAFFGVTVQ 802
             W    ++++ S    ++  G+ ++L +      D G++     E  T G     G  + 
Sbjct: 2564 LWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAIS 2623

Query: 803  DPPVH--IVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGP 860
             P     + + +E VF            CEV   D+   W +DG+ +  ++ +  E++G 
Sbjct: 2624 KPLTDQTVAESQEAVF-----------ECEVANPDSKGEWLRDGKHLPLTNNIRSESDGH 2672

Query: 861  HRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKV-----YVAAVRLER 915
             RRL++ AT+  D GE+          + V  +  S+ +   + K+      +     + 
Sbjct: 2673 KRRLIIAATKLDDIGEYT---------YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2723

Query: 916  VVLTCELCRPWAE-VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V T EL  P  + V+W K+G  +  +    +  + T+  L +    + D   Y   +  
Sbjct: 2724 AVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGR 2783

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEA 1034
              AS  + V    V+II    +VT  A+    V     +S +  PV+W+   +E++ S+ 
Sbjct: 2784 LGASARLHV--ETVKIIKKPKDVT--ALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDK 2839

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGD---DSAFF--TVTVTAPPERIVHPAARSL 1089
              L  +    +L+L    P D GE+    G     +  F  T+ +T   + I  P  ++ 
Sbjct: 2840 HRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT- 2898

Query: 1090 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
                         CEV+       W K+G+E+E S+  ++  +G    L + +   ED+ 
Sbjct: 2899 ---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSA 2949

Query: 1150 EY--VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWS 1207
            EY  VC     + T  V     P+   ++      +     + +     ++  G    W 
Sbjct: 2950 EYTFVCGNDQVSATLTV----TPIMITSM---LKDINAEEKDTITFEVTVNYEGISYKWL 3002

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE--- 1264
             NG  ++  +  ++  +     L I+      A  YT  +G A    +L    +  E   
Sbjct: 3003 KNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRK 3062

Query: 1265 --PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
                ++V+  + A                 +S P   V+W KD + L    R+++++   
Sbjct: 3063 HIKDIKVLEKKRAM------------FECEVSEPDITVQWMKDDQELQITDRIKIQKEKY 3110

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
               L +   R  DAG+Y   A      +++F+    E   V++ S    + V E   A  
Sbjct: 3111 VHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV----EGRDVRIRSIKKEVQVIEKQRAVV 3166

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRI--LTLRGCQLGDAGTVTLRAGSTA 1437
              EV+  D D  W ++G  +    Q         RI  + +   +  DAG  T  AG   
Sbjct: 3167 EFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNR 3226

Query: 1438 TSARLHVRETE-LLFLRRLQDVRAEEGQDV-CLEVETGRVGAAGAVRWVRGGQPLPHDSR 1495
            +S  L+V   E    L+ LQ V  + G+      V +GR      + W +  Q L    +
Sbjct: 3227 SSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGR--PQPKISWYKEEQLLSTGFK 3284

Query: 1496 LSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RTLARLSVRPRQL----------- 1540
                 DG  + L +      D   Y CE+ +D     T A LSV   ++           
Sbjct: 3285 CKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP 3344

Query: 1541 -RVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
              ++ PL+D   SEG  A FQ  +S   +   W     ++ P     +      ++L + 
Sbjct: 3345 PAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIA 3404

Query: 1600 GLGLADSGCVSFTADS----LRCAARL------------IVREVPVTIVRGP------HD 1637
                 D G  +F A +    +   A L            I +E+ + +   P        
Sbjct: 3405 EAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEP 3464

Query: 1638 LEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAG 1696
            LEV  G  A F CE+  A      W K G  +  S +  +++      L++ R    D G
Sbjct: 3465 LEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCG 3524

Query: 1697 TYSCAVGTARAG---PVRLTVRER-TVAVLSELRSVSAREGDGATFECTVS---EVETTG 1749
             Y+C              LTV E      LS  +S++   G  A F CTV+    +ET  
Sbjct: 3525 EYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETI- 3583

Query: 1750 RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
             W+  G  L P    RI     KHIL LS L  +D G    +A       + + E + + 
Sbjct: 3584 -WQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIID 3642

Query: 1810 MCRHPPREKTV--LVGRRAVLEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLV 1866
                    + V   + ++  LE  V       V W ++G +L PG  Y++       +L 
Sbjct: 3643 KPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLE 3702

Query: 1867 IHDVRPEDQGTYCCQAGQDS 1886
            I   + +D GTY C A  ++
Sbjct: 3703 IPLAKLKDSGTYVCTASNEA 3722



 Score =  299 bits (766), Expect = 2e-80
 Identities = 459/1989 (23%), Positives = 777/1989 (39%), Gaps = 251/1989 (12%)

Query: 20   PVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDA 79
            P+ V  G    L+C V G P   V W K G+ L +S++  F        L + +    DA
Sbjct: 5712 PMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDA 5771

Query: 80   GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWV 139
            G Y  + +N  G++   A V V            ++R +P        P F    ++   
Sbjct: 5772 GTYTFQVQNNVGKSSCTAVVDV------------SDRAVP--------PSFTRRLKNTGG 5811

Query: 140  LRGAEVVLTCRAGGLPEPTLYW--EKDGMALDEVWDSSHFALQPGRAEDGPGASLALRIL 197
            + GA  +L C+  G    ++ W  EK  +     + ++                  L++ 
Sbjct: 5812 VLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTF-----------SDNVCTLQLN 5860

Query: 198  AARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWV 257
            +    D G Y C A N  G  +  A+L V +PP S   +P        EPL+  P     
Sbjct: 5861 SLDSSDMGNYTCVAANVAGSDECRAVLTVQEPP-SFVKEP--------EPLEVLP----- 5906

Query: 258  NEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
              GK+  F   + G P  ++ W    R L+   R  +Y + D    L++        G Y
Sbjct: 5907 --GKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFE-DTVAELELFNIDISQSGEY 5963

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS-RIPTAWFRE 376
             C   N+AGQ     +L VKEP   F + L D         +LE     +  I   W ++
Sbjct: 5964 TCVVSNNAGQASCTTRLFVKEP-AAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKD 6022

Query: 377  DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRV-RTVANV---TVKGPILK 432
               +    K   +       L I      D G Y CE+     R V      T++ P   
Sbjct: 6023 GFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFV 6082

Query: 433  RLPRKLDVLEGENAVLLVETL-EAGVEGRWSRDGEEL---PVICQSSSGHMHALVLPGVT 488
                 L+   G++  L  +      +   W +   +L   P      + ++  LV   V 
Sbjct: 6083 TELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVN 6142

Query: 489  REDAGEVTF----SLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNT----VLLTWKP 540
              D+GE T     S+G + + T+ R++        PP  A   K  + T    V LT + 
Sbjct: 6143 INDSGEYTCKAENSIGTASSKTVFRIQ----ERQLPPSFARQLKDIEQTVGLPVTLTCRL 6198

Query: 541  PEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
               AP     YR +   +  ++ +Q   ++    +++    +   G Y    C+ S    
Sbjct: 6199 NGSAPIQVCWYR-DGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYS---CSAS---- 6250

Query: 601  SPHVVFHGSAHLVPTARLVAGLEDVQ-----VYDGEDAVFSLDLSTI--IQGTWFLNGEE 653
            +P      SA L       +   D++     V  GE A F   ++    ++ TW  + +E
Sbjct: 6251 NPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKE 6310

Query: 654  LKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD------SAA 707
            ++         PG   Y I   G    L +  V   DSG    ++C    D      SA 
Sbjct: 6311 IR---------PGG-NYTITCVGNTPHLRILKVGKGDSGQ---YTCQATNDVGKDMCSAQ 6357

Query: 708  LTIQESPVHILSPQDRVSLTFTTSERVVLTCELS-RVDFPATWYKDGQKVEESELLVVKM 766
            L+++E P  +   +   S      E + L C++S   +   +W+++  ++ ES    +  
Sbjct: 6358 LSVKEPPKFVKKLE--ASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSF 6415

Query: 767  DGRKHRLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVDPREHVFVHAITS 822
                  L + EA  +DSG++ C         S    +TV+ PPV    P     V A+  
Sbjct: 6416 INSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSP---VGALKG 6472

Query: 823  ECVMLACEVD-REDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC-- 879
              V+L CE+       V W KD ++V  S    + ++     L +   + SD GE+ C  
Sbjct: 6473 SDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKA 6532

Query: 880  ---VAGDECA---------YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWA 927
               V  D C+          F   ++D S+ I          AV L  +V   E  +P  
Sbjct: 6533 TNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI--------GDAVELRAIV---EGFQP-I 6580

Query: 928  EVRWTKD-GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDES----ASFTVT 982
             V W KD GE + ES    +   D +  L L + +  +SG+Y+C+I +++     S  +T
Sbjct: 6581 SVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLT 6640

Query: 983  VTEPPVRIIYPRDEVTLIA---VTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLER 1039
            V E P RII   + +T+       LECVV        +   +W+KDG E+       +  
Sbjct: 6641 VLE-PARIIEKPEPMTVTTGNPFALECVV----TGTPELSAKWFKDGRELSADSKHHITF 6695

Query: 1040 DGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTA-PPERIVHPA--ARSLDLHFGAP 1096
                  L +P A+  D G +  +  +       TV+    +RIV P+   +  D++    
Sbjct: 6696 INKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILG 6755

Query: 1097 GRVELRCEVA-PAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCET 1155
              V L C V+  A   V W++DG E+ +    Q        TL L   +P D G Y C  
Sbjct: 6756 ASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVA 6815

Query: 1156 RHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP---VVWSH 1208
             + A     +  + + EPP    + E TP  + V PG  +  +  +   G P   V W  
Sbjct: 6816 ANVAGSDECSAVLTVQEPP----SFEQTPDSVEVLPGMSLTFTSVI--RGTPPFKVKWFK 6869

Query: 1209 NGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP-- 1266
              R +  GE   +  E     L +    P  +G Y+C      G+ S +  + V EP   
Sbjct: 6870 GSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATF 6929

Query: 1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQV 1325
            V+ +A  + +T      G  + L    +G P   V W KD   ++   R  +       +
Sbjct: 6930 VKRLADFSVET------GSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTI 6983

Query: 1326 LRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRC 1381
            L +  +   D  +Y C    +A QD    LVSV EP     +  L  +    G+ AT +C
Sbjct: 6984 LEILESTIEDYAQYSCLIENEAGQDICEALVSVLEP--PYFIEPLEHVEAVIGEPATLQC 7041

Query: 1382 EV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GST 1436
            +V   P+  ++W +    +   P  +M    +   L +      D G  + +A    G+ 
Sbjct: 7042 KVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAV 7101

Query: 1437 ATSARLHVRETEL--LFLRRLQDVRAEEGQDVCLEVETGRVGAAG--AVRWVRGGQPLPH 1492
            A+SA L ++  +L   F R+L+DV    G  V  E    R+  +    V W + G  L  
Sbjct: 7102 ASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFEC---RINGSEPLQVSWYKDGVLLKD 7158

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQ---GTYGCESHHD----RTLARLSVRPRQLRVLRP 1545
            D+ L   Q   +H +    ++  DQ   G Y C + +      + A+L +   ++     
Sbjct: 7159 DANL---QTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFD 7215

Query: 1546 LEDVTI--SEGGSATFQLELSQEG-VTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
            L+ V++  + G S TF+  ++    +   WA+   ++ PG    +    +   L +  +G
Sbjct: 7216 LKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVG 7275

Query: 1603 LADSGCVSFTADSL----RCAARLIVREVPVTIVRGPHDLEVTEGDTATFECEL-SQALA 1657
              D+G  +  A ++     C+A+L V+E P  I +      V + +   +EC++      
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEI 7335

Query: 1658 DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC----AVGTARAGPVRLT 1713
             V W KD   +  S + R+  + +  +L++      D+G Y+C    A G+A +    L 
Sbjct: 7336 KVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSA-SSSTSLK 7394

Query: 1714 VRERTVAVLSELRSVSAREGDGATFECTVSEVETTG----RWELGGRPLRPGARVRIRQE 1769
            V+E  +    +   +   +G     EC   E++ T      W    R LR G + +I  E
Sbjct: 7395 VKEPPI-FRKKPHPIETLKGADVHLEC---ELQGTPPFHVSWYKDKRELRSGKKYKIMSE 7450

Query: 1770 GKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVEALPLQMCRHPPR------EKT 1819
                 + +  + A D GE + +A    G    +  + ++A        PPR      + +
Sbjct: 7451 NFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKA--------PPRFVKKLSDIS 7502

Query: 1820 VLVGRRAVLEVTVSRSGG-HVCWLREGAELC-PGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
             +VG+   L+ T+  +    V W ++  E+    D   +       +L    V P + G 
Sbjct: 7503 TVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGK 7562

Query: 1878 YCCQAGQDS 1886
            Y CQ   D+
Sbjct: 7563 YTCQIKNDA 7571



 Score =  298 bits (763), Expect = 3e-80
 Identities = 428/1996 (21%), Positives = 767/1996 (38%), Gaps = 238/1996 (11%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F +  + ++V+    A  +C V  EP   V W K  Q+L  ++R+    +   H LL+ +
Sbjct: 3060 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPS 3118

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
               +DAG Y       AG   + A + V                       EG  V +  
Sbjct: 3119 TRMSDAGKYTV----VAGGNVSTAKLFV-----------------------EGRDVRIRS 3151

Query: 134  PRSQ-WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
             + +  V+     V+        +   +W KDG+ ++      H  +   R         
Sbjct: 3152 IKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYVVERRIH------- 3203

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             + I   R  D+G Y   A    G  ++   L V+ P           P  V++ L+  P
Sbjct: 3204 RMFISETRQSDAGEYTFVA----GRNRSSVTLYVNAP----------EPPQVLQELQ--P 3247

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
             T  V  GK A+F   + G+P+P+I W+ E   LL    +  +      + L ++    +
Sbjct: 3248 VT--VQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3304

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRL------------RFTRPLQDVEGREHGIAVL 360
            D  +Y C A+N  G   ++  L V+ P +                PLQD    E   A  
Sbjct: 3305 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3364

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY---LCEMRGR 417
            +C+V  + +  +W+ +D+++ P R +   +     +L I     +D+G Y        G+
Sbjct: 3365 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3424

Query: 418  VRTVANVTVK--------------------GPILKRLPRKLDVLEGENAVLLVETLEA-G 456
            V + AN++++                     P++KR    L+V  G  A    E   A  
Sbjct: 3425 VSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPN 3484

Query: 457  VEGRWSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGN-----SRTTTLL 508
            V  +W + G E+         SS ++ +L +      D GE T    N     S T TL 
Sbjct: 3485 VRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLT 3544

Query: 509  RVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVG----SEDWI 564
              +    +    P     F G     + T         TP I  + +++      S +W 
Sbjct: 3545 VTEAYPPTFLSRPKSLTTFVGKAAKFICT------VTGTPVIETIWQKDGAALSPSPNW- 3597

Query: 565  QCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLED 624
            +    E    +E+    +   G Y  +     G       +      ++     +  LE 
Sbjct: 3598 RISDAENKHILELSNLTIQDRGVYSCKASNKFGAD-----ICQAELIIIDKPHFIKELEP 3652

Query: 625  VQ--VYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI 682
            VQ  +         +D    +  TW  +G++L          P    Y+I  +     L 
Sbjct: 3653 VQSAINKKVHLECQVDEDRKVTVTWSKDGQKL----------PPGKDYKICFEDKIATLE 3702

Query: 683  LHAVKHQDSGALVGFSCPGVQD------SAALTIQESPVHILSPQDRVSLTFTTSERVVL 736
            +   K +DSG  V   C    +      SA +T++E P  +       S      E   L
Sbjct: 3703 IPLAKLKDSGTYV---CTASNEAGSSSCSATVTVREPPSFVKKVDP--SYLMLPGESARL 3757

Query: 737  TCELSRVD-FPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECR----TE 791
             C+L        TW+K+ +++ ES  + +     +  L + + KV+DSG + C       
Sbjct: 3758 HCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVG 3817

Query: 792  GVSAFFGVTVQDPP--VHIVDPREHVFVHAITSECVMLACEVDREDA-PVRWYKDGQEVE 848
              S    + +++PP  +  ++P +      +     +L CEV       + W+KD +++ 
Sbjct: 3818 SDSCSTEIVIKEPPSFIKTLEPAD-----IVRGTNALLQCEVSGTGPFEISWFKDKKQIR 3872

Query: 849  ESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDE---CAYFTVTITDVSSWIVYPSGK 905
             S    L ++     L + +   +D GE++CV  +E   C      +       V     
Sbjct: 3873 SSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDD 3932

Query: 906  VYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDS 965
            +     +   +        P   V W K  E + E   + +   + V  L++P VQ+   
Sbjct: 3933 LIALGGQTVTLQAAVRGSEP-ISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFG 3991

Query: 966  GEYLCEIDDESASFTVT---VTEPPVRIIYPRDEVTLIA---VTLECVVLMCELSREDAP 1019
            G+Y C  ++E+ S T     + + P +II   + + + A    TLE  V        +  
Sbjct: 3992 GKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTV----AGTPELK 4047

Query: 1020 VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVT 1075
             +WYKDG  +  S+   +       +L   +A+  D G++      + G  S   T TV 
Sbjct: 4048 PKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVL 4107

Query: 1076 APPERIVHP----AARSLDLHFGAPGRVELRCEVAPA-GSQVRWYKDGLEVEASDALQLG 1130
               +R + P      R++D      G   L C++A +   +V W+KDG E+ ASD  ++ 
Sbjct: 4108 ---DRDIAPFFTKPLRNVDSVVN--GTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIA 4162

Query: 1131 AEGPTRTLTLPHAQPEDAGEYVCETRHEAITFN----VILAEPPVQFLALETTPSPLCVA 1186
                T +L +      DAG + C   +   + +    +I+ EPP    +  T P    V 
Sbjct: 4163 FVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPP----SFVTKPGSKDVL 4218

Query: 1187 PGEPVVLSCELSRAGAPVV--WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYT 1244
            PG  V L     +   P+   W    + +  G    +  E     L +     + +G YT
Sbjct: 4219 PGSAVCLKSTF-QGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYT 4277

Query: 1245 CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWY 1303
            C+     G    S  + V EP   V   E +Q   +   G   +L   ++G P   + W+
Sbjct: 4278 CKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKK---GDATQLACKVTGTPPIKITWF 4334

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQD------SRIFLVSVEEP 1357
             +   +    + ++    +  VLR+      D+GEY+C+A  +      S I +V  E P
Sbjct: 4335 ANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVK-ESP 4393

Query: 1358 LLVKLVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRIL 1416
               K   E  P+ V +  D     EV+  P  ++TW ++  ++  G + +         L
Sbjct: 4394 YFTK---EFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSL 4450

Query: 1417 TLRGCQLGDAG----TVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVET 1472
             +      DAG     VT   GS+  SAR+ +RE    F+++++   +  G     +  T
Sbjct: 4451 QILKFVAADAGEYQCRVTNEVGSSICSARVTLREPP-SFIKKIESTSSLRGGTAAFQA-T 4508

Query: 1473 GRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD----R 1528
             +      V W++    +  D  + M  + ++  L++ G+ +   G Y C++ +D    R
Sbjct: 4509 LKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQR 4568

Query: 1529 TLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELS-QEGVTGEWARGGVQLYPGPKCHI 1587
              A LSV+     +      + +++G  AT Q++ S  + +T +W + G +L  G K  I
Sbjct: 4569 CSALLSVK-EPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKI 4627

Query: 1588 HSDGHRHRLVLNGLGLADSGCVSFTADS----LRCAARLIVRE--VPVTIVRGPHDLEVT 1641
                    L +      DSG  +F   +      C AR+ V +  +P +  +    ++  
Sbjct: 4628 SVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSI 4687

Query: 1642 EGDTATFECELSQA-LADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
            +G     EC ++ +    + W KD   ++ S + +         L++ +   +D+GTY+C
Sbjct: 4688 KGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTC 4747

Query: 1701 AVGTARAG----PVRLTVRERTVAVLSELRSVSAREGDGATFECTV-SEVETTGRWELGG 1755
            +  T +AG       LTV+E    V  + +S           +  V      T +W    
Sbjct: 4748 S-ATNKAGHNQCSGHLTVKEPPYFV-EKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDN 4805

Query: 1756 RPLRPGARVRIRQEGKKHILVLSELRAEDAG----EVRFQAGPAQSLALLEVEALPLQMC 1811
            + L  GA   + ++     L L   +A D+G    ++    G A S A L V+  P Q  
Sbjct: 4806 KELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE-PPQFI 4864

Query: 1812 RHPPREKTVLVGRRAVLEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDV 1870
            + P     +  G+    E  ++ +    V W  +G E+    K+ +       +  I   
Sbjct: 4865 KKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGA 4924

Query: 1871 RPEDQGTYCCQAGQDS 1886
            R E+ GTY C+A  D+
Sbjct: 4925 RVENSGTYVCEARNDA 4940



 Score =  292 bits (747), Expect = 2e-78
 Identities = 442/1993 (22%), Positives = 753/1993 (37%), Gaps = 233/1993 (11%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP FL  P+ +    G  A+  C V G P    +W+K G  L+ S          +H L 
Sbjct: 3550 PPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILE 3609

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            L+     D GVY C+A N  G     A + +++ P    EL+P +  +            
Sbjct: 3610 LSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAI------------ 3657

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA-----E 185
                         +V L C+     + T+ W KDG  L            PG+      E
Sbjct: 3658 -----------NKKVHLECQVDEDRKVTVTWSKDGQKLP-----------PGKDYKICFE 3695

Query: 186  DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
            D       L I  A+L DSG YVC A N  G +   A + V +PP               
Sbjct: 3696 D---KIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSF------------- 3739

Query: 246  EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 305
              +K    ++ +  G+ A+  C + G P  ++ W    + L       MY       +L 
Sbjct: 3740 --VKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEA-ILD 3796

Query: 306  VLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
            +   + +D G Y C A N  G    + ++ +KEP   F + L+  +      A+L+C+V 
Sbjct: 3797 ITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPP-SFIKTLEPADIVRGTNALLQCEVS 3855

Query: 366  NSR-IPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANV 424
             +     +WF++ +++   +KY    + ++  L I    + D G Y C +   V     +
Sbjct: 3856 GTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCM 3915

Query: 425  TVKGPILKRLP---RKLDVLEGENAVLLVETLEAGVEGR------WSRDGE---ELPVIC 472
                 +LK  P   +K+D L       +  TL+A V G       W +  E   E   I 
Sbjct: 3916 ATH--LLKEPPTFVKKVDDLIALGGQTV--TLQAAVRGSEPISVTWMKGQEVIREDGKIK 3971

Query: 473  QSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKN 532
             S S  +  L++P V      +++F     + T L   +    +  G  I+ E  K  + 
Sbjct: 3972 MSFSNGVAVLIIPDV------QISFG---GKYTCLAENEAGSQTSVGELIVKEPAKIIER 4022

Query: 533  TVLLTWKPPEPA---------PET-PFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCV 582
              L+     +PA         PE  P  Y+  R  V S+ +   F    A       +  
Sbjct: 4023 AELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELH 4082

Query: 583  PSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI 642
             S G Y F I    G              + P         D  V         +  S  
Sbjct: 4083 DS-GQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLP 4141

Query: 643  IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP-- 700
            ++ +WF +G+E+ +++          RYRI        L +  V   D+G    F+C   
Sbjct: 4142 MRVSWFKDGKEIAASD----------RYRIAFVEGTASLEIIRVDMNDAG---NFTCRAT 4188

Query: 701  ---GVQDSA-ALTIQESPVHILSPQDR-------VSLTFTTSERVVLTCELSRVDFPATW 749
               G +DS+ AL +QE P  +  P  +       V L  T      LT           W
Sbjct: 4189 NSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIR---------W 4239

Query: 750  YKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE----GVSAFFGVTVQDPP 805
            +K  +++       +  +  +  L L   K  DSG + C+      GV     + V++P 
Sbjct: 4240 FKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPA 4299

Query: 806  VHI--VDPREHVFVHAITSECVMLACEVD-REDAPVRWYKDGQEVEESDFVVLENEGPHR 862
              +  ++P + +       +   LAC+V       + W+ + +E++ES    +       
Sbjct: 4300 TFVEKLEPSQLLK----KGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTA 4355

Query: 863  RLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVY-------VAAVRLER 915
             L L      D GE+ C A +E        +D  S IV      Y       +  ++   
Sbjct: 4356 VLRLTDVGIEDSGEYMCEAQNEAG------SDHCSSIVIVKESPYFTKEFKPIEVLKEYD 4409

Query: 916  VVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
            V+L  E+   P  E+ W KD   +          +D +  L +      D+GEY C + +
Sbjct: 4410 VMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTN 4469

Query: 975  ESASFT----VTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP--VRWYKDGLE 1028
            E  S      VT+ EPP  I       +L   T      +    +   P  V W KD  E
Sbjct: 4470 EVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATL----KGSLPITVTWLKDSDE 4525

Query: 1029 VEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAF--FTVTVTAPPERIVHPAA 1086
            + E + + +  +     L L   + +  G++VC A +D+     +  ++      +   A
Sbjct: 4526 ITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEA 4585

Query: 1087 RSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPE 1146
             S+D+  G P  ++++          +W+KDG E+      ++        L +   + +
Sbjct: 4586 VSIDVTQGDPATLQVKFS-GTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKK 4644

Query: 1147 DAGEYVCETRHEA------ITFNVI-LAEPPVQFLALETTPSPLCVAPGEPVVLSCELSR 1199
            D+GEY  E +++          NV+ L  PP     L+   S      G  + L C ++ 
Sbjct: 4645 DSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDS----IKGSFIDLECIVAG 4700

Query: 1200 AGA-PVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSF 1258
            +    + W  + + +   E  +         L I       +G YTC +    G    S 
Sbjct: 4701 SHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSG 4760

Query: 1259 TVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGG-PVRWYKDGERLASQGRVQL 1317
             + V EPP  V  P++        P   ++L   + G     ++W+KD + L S     +
Sbjct: 4761 HLTVKEPPYFVEKPQSQDVN----PNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSV 4816

Query: 1318 EQAGARQVLRVQGARSGDAGEYLCDAPQD-----SRIFLVSVEEPLLVKLVSELTPLTVH 1372
             +      L +  A++ D+G Y+C    D     S+  L   E P  +K  S +  L + 
Sbjct: 4817 WKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPV--LVLR 4874

Query: 1373 EGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTL 1431
             G   TF C+++  P   V+W  +G  +T   +  ++         + G ++ ++GT   
Sbjct: 4875 NGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVC 4934

Query: 1432 RA----GSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVE-TGRVGAAGAVRWVRG 1486
             A    G+ + S  L V+E    F+R L+ V   +  DV LE E TG       V W++ 
Sbjct: 4935 EARNDAGTASCSIELKVKEPPT-FIRELKPVEVVKYSDVELECEVTGT--PPFEVTWLKN 4991

Query: 1487 GQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVR---PRQLRVL 1543
             + +    + ++     +  L I     +D G Y C   ++      S R         +
Sbjct: 4992 NREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFI 5051

Query: 1544 RPLEDVTISEGGSATFQLELS-QEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
            + +E+ T     SATFQ  ++    ++  W +    L      +I        L +  + 
Sbjct: 5052 KKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVD 5111

Query: 1603 LADSGCVSFTADSL----RCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALA- 1657
               SG  +  A +     RC A L+V+E P  IV     ++VTE D  T EC ++     
Sbjct: 5112 NGHSGRYTCQAKNESGVERCYAFLLVQE-PAQIVEKAKSVDVTEKDPMTLECVVAGTPEL 5170

Query: 1658 DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGT---ARAGPVRLTV 1714
             V W KDG  + PS    +         +++     D+G Y+  V     + +    L V
Sbjct: 5171 KVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRV 5230

Query: 1715 RERTV--AVLSELRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGK 1771
             ++ +  +   +L  +    G     EC VS  +  + +W   G+ +   A+ R+    +
Sbjct: 5231 LDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHER 5290

Query: 1772 KHILVLSELRAEDAG----EVRFQAGPAQSLALLEVEALPLQMCRHPPREKTV---LVGR 1824
               L ++ L  ED      +V   AG      +L V+  P  + + P R++ +    V  
Sbjct: 5291 SVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVK-PGRQQAIPDSTVEF 5349

Query: 1825 RAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC---- 1880
            +A+L+ T       + W ++  EL  G K  +   G T  L ++ V     G Y C    
Sbjct: 5350 KAILKGTPPFK---IKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 5406

Query: 1881 QAGQDSTHTRLLV 1893
              G DS  T LLV
Sbjct: 5407 DVGSDSCTTMLLV 5419



 Score =  291 bits (746), Expect = 3e-78
 Identities = 426/1910 (22%), Positives = 711/1910 (37%), Gaps = 212/1910 (11%)

Query: 7    DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
            D+  PP F+R  + V  + GA   L+C V G  P  V W + G ++ +  +         
Sbjct: 6736 DRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENV 6795

Query: 67   HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEG 126
              L L+   P+D G+Y C A N AG    +A +TV EPP+                    
Sbjct: 6796 CTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPS-------------------- 6835

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
               F   P S  VL G  +  T    G P   + W K    L    +S + +L+    E 
Sbjct: 6836 ---FEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSREL-VPGESCNISLEDFVTE- 6890

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
                   L +   +  +SG Y C   N  G A     L V +            PA  V+
Sbjct: 6891 -------LELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKE------------PATFVK 6931

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
             L      F V  G          G P   + W  +   L+    R      +   +L++
Sbjct: 6932 RL----ADFSVETGSPIVLEATYTGTPPISVSW-IKDEYLISQSERCSITMTEKSTILEI 6986

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            L    +D   Y C   N AGQ +    + V EP   F  PL+ VE      A L+CKV  
Sbjct: 6987 LESTIEDYAQYSCLIENEAGQDICEALVSVLEPPY-FIEPLEHVEAVIGEPATLQCKVDG 7045

Query: 367  S-RIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
            +  I  +W++E  +L     Y+   +  V  L+I+++   D G Y C+    V  VA+  
Sbjct: 7046 TPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSA 7105

Query: 426  VKGPILKRLP----RKL-DVLEGENAVLLVETLEAGVEG---RWSRDGEELPVICQSSSG 477
            V     ++LP    RKL DV E     +  E    G E     W +DG  L       + 
Sbjct: 7106 VLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTS 7165

Query: 478  HMHALVLPGVTRED---AGEVTFSLGNSRTTTLLRVKCV--KHSPPG----PPILAEMFK 528
             +H +    + + D    G+   S  N   T     K +  +H  P      P+  ++  
Sbjct: 7166 FVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLAL 7225

Query: 529  GHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDY 588
            G   T         P   T   +  + +E+      +   +E    + V        G Y
Sbjct: 7226 GESGTFKCHVTGTAPIKIT---WAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQY 7282

Query: 589  RFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAV---FSLDLSTIIQG 645
                  ++G              +    R +  LE  ++   ++       +  S  I+ 
Sbjct: 7283 TCYASNIAGKDSC-----SAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKV 7337

Query: 646  TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP----- 700
             W+ +  E++ +           ++R+        L +H +  +DSG    ++C      
Sbjct: 7338 LWYKDETEIQESS----------KFRMSFVDSVAVLEMHNLSVEDSG---DYTCEAHNAA 7384

Query: 701  -GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV-DFPATWYKDGQKVEE 758
                 S +L ++E P+    P    +L       V L CEL     F  +WYKD +++  
Sbjct: 7385 GSASSSTSLKVKEPPIFRKKPHPIETL---KGADVHLECELQGTPPFHVSWYKDKRELRS 7441

Query: 759  SELLVVKMDGRKHRLILPEAKVQDSGEFECRTE---GVSAFFG-VTVQDPPVHIVDPREH 814
             +   +  +     + +      D GE++C+     G     G + ++ PP  +   ++ 
Sbjct: 7442 GKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFV---KKL 7498

Query: 815  VFVHAITSECVMLACEVD-REDAPVRWYKD-GQEVEESDFVVLENEGPHRRLVLPATQPS 872
              +  +  + V L   ++  E   V W+KD G+ V ESD + +        L     +P+
Sbjct: 7499 SDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPA 7558

Query: 873  DGGEFQCV----AGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWA 927
            + G++ C     AG +  + T+++ + ++ +  P     +     +   L C +   P  
Sbjct: 7559 NAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPES---IKVTTGDTCTLECTVAGTPEL 7615

Query: 928  EVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD----ESASFTVTV 983
              +W KDG+E+       +   + V  L +  V   DSG Y  E+ +    +S + ++ V
Sbjct: 7616 STKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQV 7675

Query: 984  TEPPVRIIYPRDEVTLIAVTLECVVLMCEL-SREDAPVRWYKDGLEVEESEALVLERDGP 1042
            ++  V   + R       ++   VV+ C++       V W+ +G E+             
Sbjct: 7676 SDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDN 7735

Query: 1043 RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR 1098
             C L +   +  D G++ C     AG D     +TV  PP  +  P    +D+  G    
Sbjct: 7736 TCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKP--DPMDVLTGTNVT 7793

Query: 1099 VELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHE 1158
                 +  P  S V W+K   E+   D   +  E     L L       +GEY C   +E
Sbjct: 7794 FTSIVKGTPPFS-VSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNE 7852

Query: 1159 AITFNV---ILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP---VVWSHNGRP 1212
            A   +    +  + P +F+      S   +  G+P++L  E +  G P   V W  NG  
Sbjct: 7853 AGKASCTTHLYIKAPAKFVKRLNDYS---IEKGKPLIL--EGTFTGTPPISVTWKKNGIN 7907

Query: 1213 VQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
            V   +   +       +L I ++    AG Y C    A G  S S  + + EPP  V   
Sbjct: 7908 VTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQL 7967

Query: 1273 EAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGA 1331
            E  +  V    G    L   L+G P   V WYK   +L      ++        L     
Sbjct: 7968 EPVKVSV----GDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQV 8023

Query: 1332 RSGDAGEYLCDAPQ-----DSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPP 1386
               D+GEY+C A        +  FL   E+ L      +L  +    G    F C +S  
Sbjct: 8024 DINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGS 8083

Query: 1387 D-ADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAG----TVTLRAGSTATSAR 1441
            +   V+W ++G  +   P V+ +   ++  L +       AG    T T   GS ++SAR
Sbjct: 8084 EPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSAR 8143

Query: 1442 LHVRE--TELLFLRRLQDVRAEEGQDVCLEVE-TGRVGAAGAVRWVRGGQPLPHDSRLSM 1498
            L + E      F  RL  V A  G+    E   TG       V W +  + +    +  +
Sbjct: 8144 LILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPI--KVSWAKDSREIRSGGKYQI 8201

Query: 1499 AQDGHIHRLFIHGVILADQGTYGC----ESHHDRTLARLSVRPRQLR---VLRPLEDVTI 1551
            +   +   L +  V   D G Y C    E   D   A+L+++ R +      R  E V  
Sbjct: 8202 SYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEE 8261

Query: 1552 SEGGSATFQLE---LSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC 1608
            +EG S  F+LE      + +T  W +  +++ P   C I    +   L +   G+ D+G 
Sbjct: 8262 TEGNS--FKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGL 8319

Query: 1609 ----VSFTADSLRCAARLIVREVPVTIVRGPH--DLEVTEGDTATFECEL-SQALADVTW 1661
                VS  A S  C + ++++E     V   H   + V+EG+     C +       + W
Sbjct: 8320 YTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQW 8379

Query: 1662 EKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPV---RLTVRERT 1718
             K G  + PS R          +L+LR    +D+G Y C             ++T++++ 
Sbjct: 8380 LKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKP 8439

Query: 1719 VAV--------------LSELRSVSAREGDGATFECTV------SEVETTGRWELGGRPL 1758
                             +SE +S+   E   ATF   V      +   T G+W    R L
Sbjct: 8440 AVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKW----RQL 8495

Query: 1759 RPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVE 1804
              G RV I Q+G +  L + +    D+G  R  A    G  +S   L+V+
Sbjct: 8496 NQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVD 8545



 Score =  291 bits (745), Expect = 4e-78
 Identities = 315/1294 (24%), Positives = 508/1294 (39%), Gaps = 122/1294 (9%)

Query: 674  QKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA-LTIQESPVHILSPQDRVSLTFTTSE 732
            +KGLQ    L  + H+  GAL G +    +     + +   PV +L             E
Sbjct: 1810 RKGLQRIEELERMAHE--GALTGVTTDQKEKQKPDIVLYPEPVRVLE-----------GE 1856

Query: 733  RVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE 791
                 C ++    P   WY +GQ + +S+   V+ DG  H L + + K  D+GE +   E
Sbjct: 1857 TARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGEVKVTAE 1915

Query: 792  GVSAFFGVTVQDPPVHIV-------------DPREHVFVHAITSECVMLACEVDREDAPV 838
                  GV      + I              +PR    VH    E   L  EV + D PV
Sbjct: 1916 NPE---GVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVH----EPGKLQFEVQKVDRPV 1968

Query: 839  -----------------RWYKDGQEVEE--SDFVVLENEGPHRRLV---LPATQPSDG-G 875
                                K  +E EE  S F     EG +  +    L + +  +   
Sbjct: 1969 DTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYE 2028

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL------------- 922
            E      DE  ++T  +T+     +   GK+ +   + +++ L+  +             
Sbjct: 2029 ELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQT 2088

Query: 923  --------------CRPWAEVRWTKDGEEVVESPALLLQ-KEDTVRRLVLPAVQLEDSGE 967
                           +P  E  W K+G ++  S  +     ED V  LV+  V  EDS  
Sbjct: 2089 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSAS 2148

Query: 968  YLCE---IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM-CELSREDAPVRWY 1023
             + +   I  E++S    + +    I + ++   ++A   + +    CE S     V+WY
Sbjct: 2149 IMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWY 2208

Query: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVH 1083
            KDG+EV E +   +  D     L +      D  ++ C   +D    T         +V 
Sbjct: 2209 KDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVE 2268

Query: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHA 1143
                  D+        EL C V+P   + +WY + +E++++    + +    + LT+   
Sbjct: 2269 FVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDV 2328

Query: 1144 QPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP 1203
              ED GEY      +  T  + +   P+  L      S   V  G+ V L  ++S     
Sbjct: 2329 TKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQ---GLSDQKVCEGDIVQLEVKVSLESVE 2385

Query: 1204 VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVA 1263
             VW  +G+ VQ  + + +  +    +L I+      AG Y+    A      LS + +V+
Sbjct: 2386 GVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPAL----GLSTSGRVS 2441

Query: 1264 EPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG-GPVRWYKDGERLASQGRVQLEQAGA 1322
               V V+ P      V    G    L   +S P    V+WY + E++    RVQ    G 
Sbjct: 2442 VYSVDVITP---LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT 2498

Query: 1323 RQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE 1382
            +Q L +    + D G Y     +      +SVE+   +K++  L  LT  E  +  F  E
Sbjct: 2499 KQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK---IKIIRGLRDLTCTETQNVVFEVE 2555

Query: 1383 VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARL 1442
            +S    DV W      + P  + ++  +G    LT+      D G  T  AG   TS +L
Sbjct: 2556 LSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKL 2615

Query: 1443 HVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG 1502
             V    +   + L D    E Q+   E E     + G   W+R G+ LP  + +    DG
Sbjct: 2616 TVAGGAIS--KPLTDQTVAESQEAVFECEVANPDSKG--EWLRDGKHLPLTNNIRSESDG 2671

Query: 1503 HIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE 1562
            H  RL I    L D G Y  +    +T A+L V    +++ + L+++T++E   A F +E
Sbjct: 2672 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEA--VKIKKTLKNLTVTETQDAVFTVE 2729

Query: 1563 LSQEGVTG-EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAAR 1621
            L+   V G +W + GV L    K  I   G  + L +    + D     F    L  +AR
Sbjct: 2730 LTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASAR 2789

Query: 1622 LIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGT 1681
            L V  V   I++ P D+   E  T  FE  +S     V W      + PS + RL +   
Sbjct: 2790 LHVETVK--IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERK 2847

Query: 1682 RRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECT 1741
               L L+   PSDAG Y+  VG       +  +   T+ +   ++++   E   A+FEC 
Sbjct: 2848 VHKLMLQNISPSDAGEYTAVVGQLEC---KAKLFVETLHITKTMKNIEVPETKTASFECE 2904

Query: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALL 1801
            VS       W   G  +    + +I  +GK H L++     ED+ E  F  G  Q  A L
Sbjct: 2905 VSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATL 2964

Query: 1802 EVEALPL-QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860
             V  + +  M +    E+   +      EVTV+  G    WL+ G E+   DK +MR+  
Sbjct: 2965 TVTPIMITSMLKDINAEEKDTI----TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKK 3020

Query: 1861 PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             THSL I +V   D   Y   AG+ ++   L VE
Sbjct: 3021 LTHSLNIRNVHFGDAADYTFVAGKATSTATLYVE 3054



 Score =  291 bits (745), Expect = 4e-78
 Identities = 432/1991 (21%), Positives = 744/1991 (37%), Gaps = 224/1991 (11%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P F   P  + V++G  A+ +C V G  P  + W K  +++      +    G    L +
Sbjct: 6271 PFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRI 6330

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
                  D+G Y C+A N  G+   +A ++V EPP    +L+                   
Sbjct: 6331 LKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEA------------------ 6372

Query: 132  TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS 191
                S+   +G  + L C+  G PE  + W ++   L E W  +   +          + 
Sbjct: 6373 ----SKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFIN---------SV 6419

Query: 192  LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCA 251
              L I  A   DSG Y+C A N  G A     L V  PP        + P+PV       
Sbjct: 6420 ALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFT-----QKPSPV------- 6467

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
                   +G     +C + G P  E+ W  + R  + + ++     +     L +L  +A
Sbjct: 6468 ----GALKGSDVILQCEISGTPPFEVVWV-KDRKQVRNSKKFKITSKHFDTSLHILNLEA 6522

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR-IP 370
             D G Y C A N  G    +  +  KEP  RF + L D          L   V   + I 
Sbjct: 6523 SDVGEYHCKATNEVGSDTCSCSVKFKEPP-RFVKKLSDTSTLIGDAVELRAIVEGFQPIS 6581

Query: 371  TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRL---KADDDGIYLCEMR---GRVRTVANV 424
              W ++   ++  R+ E      +  +   +L   +A + G Y+C+++   G     A +
Sbjct: 6582 VVWLKDRGEVI--RESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVL 6639

Query: 425  TVKGPI-LKRLPRKLDVLEGENAVL-LVETLEAGVEGRWSRDGEELPVICQSSSGHMH-- 480
            TV  P  +   P  + V  G    L  V T    +  +W +DG EL    +     ++  
Sbjct: 6640 TVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKV 6699

Query: 481  -ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKN----TVL 535
             +L +P     D G  +F + NS   +   V         PP      K        +V+
Sbjct: 6700 ASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVV 6759

Query: 536  LTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTV 595
            L  +    AP +   ++ +  E+ S    Q    E    + +        G Y      V
Sbjct: 6760 LECRVSGSAPISVGWFQ-DGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANV 6818

Query: 596  SGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT------WFL 649
            +G      V+   +    P+       + V+V  G     SL  +++I+GT      WF 
Sbjct: 6819 AGSDECSAVL---TVQEPPSFEQTP--DSVEVLPG----MSLTFTSVIRGTPPFKVKWFK 6869

Query: 650  NGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA-- 707
               EL   E             I  +     L L  V+  +SG    +SC    D+ +  
Sbjct: 6870 GSRELVPGES----------CNISLEDFVTELELFEVQPLESG---DYSCLVTNDAGSAS 6916

Query: 708  ----LTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD-FPATWYKDGQKVEESELL 762
                L ++E    +    D    +  T   +VL    +       +W KD   + +SE  
Sbjct: 6917 CTTHLFVKEPATFVKRLAD---FSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERC 6973

Query: 763  VVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF----FGVTVQDPPVHIVDPREHVFVH 818
             + M  +   L + E+ ++D  ++ C  E  +        V+V +PP + ++P EHV   
Sbjct: 6974 SITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPP-YFIEPLEHV--E 7030

Query: 819  AITSECVMLACEVD-REDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEF 877
            A+  E   L C+VD   +  + WYK+  ++  +    ++ +     LV+     SD GE+
Sbjct: 7031 AVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEY 7090

Query: 878  QCVAGDECA-----------------YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTC 920
             C A +                    +F   + DV   + +P             V   C
Sbjct: 7091 SCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFP-------------VAFEC 7137

Query: 921  EL--CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE--- 975
             +    P  +V W KDG  + +   L       V  L +        G+Y C   +    
Sbjct: 7138 RINGSEP-LQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGT 7196

Query: 976  -SASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVR--WYKDGLEVEES 1032
             S+S  + ++E  V   +    V++     E     C ++   AP++  W KD  E+   
Sbjct: 7197 ASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPG 7255

Query: 1033 EALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTAPPERIVHPAARS 1088
                +        L +      D G++ C A    G DS    + V  PP R +     S
Sbjct: 7256 GNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPP-RFIKKLEPS 7314

Query: 1089 LDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDA 1148
              +      R E +   +P   +V WYKD  E++ S   ++        L + +   ED+
Sbjct: 7315 RIVKQDEFTRYECKIGGSPE-IKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDS 7373

Query: 1149 GEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP- 1203
            G+Y CE  + A     + ++ + EPP+        P P+    G  V L CEL   G P 
Sbjct: 7374 GDYTCEAHNAAGSASSSTSLKVKEPPI----FRKKPHPIETLKGADVHLECELQ--GTPP 7427

Query: 1204 --VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQ 1261
              V W  + R ++ G+  ++ +E     + I     A  G Y C++    G+ +   ++ 
Sbjct: 7428 FHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIA 7487

Query: 1262 VAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGG-PVRWYKD-GERLASQGRVQLEQ 1319
            +  PP  V       T V    G +++L   + G     V W+KD GE +     + +  
Sbjct: 7488 LKAPPRFVKKLSDISTVV----GKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISY 7543

Query: 1320 AGARQVLRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGD 1375
            +     L+       +AG+Y C    DA        +SV EP  +  V +   + V  GD
Sbjct: 7544 SENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATI--VEKPESIKVTTGD 7601

Query: 1376 DATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA- 1433
              T  C V+  P+    W ++G  +T   + +++       L +      D+G  +    
Sbjct: 7602 TCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQ 7661

Query: 1434 ---GSTATSARLHVRETEL--LFLRRLQDVRAEEGQDVCLEVETGRVGAAG-AVRWVRGG 1487
               G  + +A L V +  +   F R+L++     G  V +E +    G+   +V W   G
Sbjct: 7662 NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKV--YGSPPISVSWFHEG 7719

Query: 1488 QPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH----DRTLARLSVRPRQLRVL 1543
              +    +       +   L ++ +  +D G Y C + +    D   A L+VR     V 
Sbjct: 7720 NEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQ 7779

Query: 1544 RPLEDVTISEGGSATF-QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
            +P + + +  G + TF  +       +  W +G  +L PG +C++  +     L L  + 
Sbjct: 7780 KP-DPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVD 7838

Query: 1603 LADSG----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALA- 1657
             + SG     VS  A    C   L ++  P   V+  +D  + +G     E   +     
Sbjct: 7839 TSQSGEYTCIVSNEAGKASCTTHLYIK-APAKFVKRLNDYSIEKGKPLILEGTFTGTPPI 7897

Query: 1658 DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR---AGPVRLTV 1714
             VTW+K+G  +TPS R  +       +L++      DAG Y+C +  A    +   ++ +
Sbjct: 7898 SVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILI 7957

Query: 1715 RERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKH 1773
             E    V  +L  V    GD A+ +C ++     G  W  G   LRP    ++       
Sbjct: 7958 LEPPYFV-KQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVA 8016

Query: 1774 ILVLSELRAEDAGEVRFQAG------PAQSLALLEVEALPLQMCRHPPREKTVLVGRRAV 1827
             LV +++   D+GE   +A        A +   ++ + LP    R   R+    VG   V
Sbjct: 8017 TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQ-LRDVQETVGLPVV 8075

Query: 1828 LEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA---- 1882
             +  +S S    V W ++G  L      +      T +L I        G Y C A    
Sbjct: 8076 FDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPI 8135

Query: 1883 GQDSTHTRLLV 1893
            G  S+  RL++
Sbjct: 8136 GSASSSARLIL 8146



 Score =  289 bits (740), Expect = 2e-77
 Identities = 434/1981 (21%), Positives = 741/1981 (37%), Gaps = 197/1981 (9%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  L+  +PV V SG  A    V+ G P P + W K  Q L+   +  F  DG E+ LL
Sbjct: 3238 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3297

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            L  A P DA VY C A+N  G A  +A+++V  P    P+ +    P          P  
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP----------PAI 3347

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +T  +      G      CR  G      ++ KD     ++  S  F +   + ED    
Sbjct: 3348 ITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKD----KKIKPSRFFRMT--QFED---- 3397

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE------SPPADPDEAPAPV 244
            +  L I  A   D G Y   A NA G   + A L +  P            + +   APV
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPV 3457

Query: 245  ----VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
                +EPL+ A        G  AKF C +   P    +W   GR +  +  +   R    
Sbjct: 3458 IKRKIEPLEVA-------LGHLAKFTCEIQSAPNVRFQWFKAGREIY-ESDKCSIRSSKY 3509

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE--PRLRFTRP--LQDVEGREHG 356
               L++L  Q  D G Y C A N  G       L V E  P    +RP  L    G+   
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGK--- 3566

Query: 357  IAVLECKVPNSR-IPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR 415
             A   C V  +  I T W ++   L P   +   +      L +  L   D G+Y C+  
Sbjct: 3567 AAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKAS 3626

Query: 416  GRVRTVANVTVKGPILKRLPRKLDVLEG-ENAVLLVETLEAGVEG------RWSRDGEEL 468
             +    A++     I+   P  +  LE  ++A+     LE  V+        WS+DG++L
Sbjct: 3627 NKFG--ADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKL 3684

Query: 469  P-----VICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG---- 519
            P      IC      +  L +P    +D+G    +  N   ++          PP     
Sbjct: 3685 PPGKDYKICFEDK--IATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKK 3742

Query: 520  --PPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEV 577
              P  L  M  G    +    K    +P     +    +E+   + ++ + +     +++
Sbjct: 3743 VDPSYL--MLPGESARLHCKLK---GSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDI 3797

Query: 578  PGDCVPSEGDYRFR-ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFS 636
                V   G Y    +  V     S  +V       + T      LE   +  G +A+  
Sbjct: 3798 TDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKT------LEPADIVRGTNALLQ 3851

Query: 637  LDLSTI--IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGAL 694
             ++S     + +WF + ++++S++          +YR+     Q  L+   +   +S  +
Sbjct: 3852 CEVSGTGPFEISWFKDKKQIRSSK----------KYRLFS---QKSLVCLEIFSFNSADV 3898

Query: 695  VGFSCPGVQD------SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD-FPA 747
              + C    +       A   ++E P  +    D ++L     + V L   +   +    
Sbjct: 3899 GEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIAL---GGQTVTLQAAVRGSEPISV 3955

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE---GVSAFFGVTVQDP 804
            TW K  + + E   + +        LI+P+ ++   G++ C  E   G     G  +   
Sbjct: 3956 TWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKE 4015

Query: 805  PVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRL 864
            P  I++  E + V A     +        E  P +WYKDG+ +  S    +  +    +L
Sbjct: 4016 PAKIIERAELIQVTAGDPATLEYTVAGTPELKP-KWYKDGRPLVASKKYRISFKNNVAQL 4074

Query: 865  VLPATQPSDGGEFQCVAGDEC------AYFTVTITDVSSWIVYPSGKVYVAAVRLERVVL 918
               + +  D G++     +E         FTV   D++ +   P     V +V      L
Sbjct: 4075 KFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRN--VDSVVNGTCRL 4132

Query: 919  TCELCRPW-AEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EID 973
             C++       V W KDG+E+  S    +   +    L +  V + D+G + C     + 
Sbjct: 4133 DCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVG 4192

Query: 974  DESASFTVTVTEPPVRIIYP--RDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEE 1031
             + +S  + V EPP  +  P  +D +   AV L+              +RW+K   E+  
Sbjct: 4193 SKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTF----QGSTPLTIRWFKGNKELVS 4248

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV---TAPPERIVHPAARS 1088
              +  + ++     L L   +  D G + C   + +     +       P   V     S
Sbjct: 4249 GGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPS 4308

Query: 1089 LDLHFGAPGRVELRCEVAPAGS-QVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPED 1147
              L  G     +L C+V      ++ W+ +  E++ S   ++     T  L L     ED
Sbjct: 4309 QLLKKG--DATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIED 4366

Query: 1148 AGEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP 1203
            +GEY+CE ++EA     +  VI+ E P  +   E    P+ V     V+L  E+  AG P
Sbjct: 4367 SGEYMCEAQNEAGSDHCSSIVIVKESP--YFTKEF--KPIEVLKEYDVMLLAEV--AGTP 4420

Query: 1204 ---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV 1260
               + W  +   ++ G   +   +     L I     A AG Y C+     G+   S  V
Sbjct: 4421 PFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARV 4480

Query: 1261 QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGP-GGPVRWYKDGERLASQGRVQLEQ 1319
             + EPP  +   E+      S  GG       L G     V W KD + +     +++  
Sbjct: 4481 TLREPPSFIKKIESTS----SLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTF 4536

Query: 1320 AGARQVLRVQGARSGDAGEYLCDAPQDSRI----FLVSVEEPLLVKLVSELTPLTVHEGD 1375
                  L + G      G+Y+C A  D+ I     L+SV+EP    +  E   + V +GD
Sbjct: 4537 ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEP--ATITEEAVSIDVTQGD 4594

Query: 1376 DATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR-- 1432
             AT + + S   +    W ++G  +T G + +++   +  IL +   +  D+G  T    
Sbjct: 4595 PATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQ 4654

Query: 1433 --AGSTATSARLHVRETEL--LFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQ 1488
               G ++  AR++V +  +   F ++L+ + + +G  + LE          +++W +  Q
Sbjct: 4655 NDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPI-SIQWFKDDQ 4713

Query: 1489 PLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC----ESHHDRTLARLSVRPRQLRVLR 1544
             +    +   +   +   L I  +   D GTY C    ++ H++    L+V+     V +
Sbjct: 4714 EISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEK 4773

Query: 1545 P-LEDVTISEGGSATFQLELSQEG---VTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNG 1600
            P  +DV      +   QL+    G   +T +W +   +L+ G    +  D     L L  
Sbjct: 4774 PQSQDV----NPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFA 4829

Query: 1601 LGLADSGC----VSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QA 1655
                DSG     +S    +    A L V+E P  I +    L +  G + TFEC+++   
Sbjct: 4830 AKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTP 4889

Query: 1656 LADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTARAGPVR 1711
               V+W  DGN +T   +  +  +      Q+      ++GTY C      GTA    + 
Sbjct: 4890 KIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCS-IE 4948

Query: 1712 LTVRERTVAVLSELRSVSAREGDGATFECTVS---EVETTGRWELGGRPLRPGARVRIRQ 1768
            L V+E     + EL+ V   +      EC V+     E T  W    R +R   +  +  
Sbjct: 4949 LKVKE-PPTFIRELKPVEVVKYSDVELECEVTGTPPFEVT--WLKNNREIRSSKKYTLTD 5005

Query: 1769 EGKKHILVLSELRAEDAGE---VRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRR 1825
                  L +++    D GE   +    G + S +       P    +      TVL    
Sbjct: 5006 RVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSA 5065

Query: 1826 AVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQD 1885
                         + WL++   L   D   +       +L I  V     G Y CQA  +
Sbjct: 5066 TFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNE 5125

Query: 1886 S 1886
            S
Sbjct: 5126 S 5126



 Score =  284 bits (726), Expect = 7e-76
 Identities = 441/1958 (22%), Positives = 748/1958 (38%), Gaps = 188/1958 (9%)

Query: 11   PPCFLRFPRPVRVVSGAEA-ELKCVVLGEPPPVVVWEKGGQQLAASE--RLSFPADGAEH 67
            P  F+    P +++   +A +L C V G PP  + W    +++  S   R+SF    A  
Sbjct: 4298 PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAV- 4356

Query: 68   GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
             L LT     D+G Y+C A+N AG  + ++ V V E P    E +P E            
Sbjct: 4357 -LRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIE------------ 4403

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
                       VL+  +V+L     G P   + W KD   L        F          
Sbjct: 4404 -----------VLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDH------ 4446

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
                ++L+IL     D+G Y C   N  G +   A + + +PP                 
Sbjct: 4447 ---LVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSF--------------- 4488

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFVLKV 306
            +K    T  +  G  A F+  + G     + W  +   +  D   R+ + +      L  
Sbjct: 4489 IKKIESTSSLRGGT-AAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSG 4547

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            +  + K  G YVC A+N AG    +  L VKEP    T     ++  +   A L+ K   
Sbjct: 4548 I--EVKHDGKYVCQAKNDAGIQRCSALLSVKEPAT-ITEEAVSIDVTQGDPATLQVKFSG 4604

Query: 367  SRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVA 422
            ++  TA WF++ Q L    KY+     TV  L I   +  D G Y  E++   GR    A
Sbjct: 4605 TKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKA 4664

Query: 423  NVTVKGPIL-----KRLPRKLDVLEGENAVLLVETLEAG---VEGRWSRDGEELPVICQ- 473
             + V   I+     K+L +K+D ++G  + + +E + AG   +  +W +D +E+    + 
Sbjct: 4665 RINVLDLIIPPSFTKKL-KKMDSIKG--SFIDLECIVAGSHPISIQWFKDDQEISASEKY 4721

Query: 474  --SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKH-SPPGPPILAEMFKG- 529
              S   +   L +  +   D+G  T S  N         +C  H +   PP   E  +  
Sbjct: 4722 KFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHN----QCSGHLTVKEPPYFVEKPQSQ 4777

Query: 530  --HKNT-VLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG 586
              + NT V L       AP T   ++ + +E+ S      +  + + ++E+        G
Sbjct: 4778 DVNPNTRVQLKALVGGTAPMTIKWFK-DNKELHSGAARSVWKDDTSTSLELFAAKATDSG 4836

Query: 587  DYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI--IQ 644
             Y  ++    G   S   +F       P   +      + + +G+   F   ++    I+
Sbjct: 4837 TYICQLSNDVGTATSKATLFVKE----PPQFIKKPSPVLVLRNGQSTTFECQITGTPKIR 4892

Query: 645  GTWFLNGEELKSNEPEG-QVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQ 703
             +W+L+G E+ + +  G     G   ++I    +++          D+G     SC    
Sbjct: 4893 VSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTA---SC---- 4945

Query: 704  DSAALTIQESPVHI--LSPQDRVSLTFTTSERVVLTCELSRVD-FPATWYKDGQKVEESE 760
             S  L ++E P  I  L P + V  +      V L CE++    F  TW K+ +++  S+
Sbjct: 4946 -SIELKVKEPPTFIRELKPVEVVKYS-----DVELECEVTGTPPFEVTWLKNNREIRSSK 4999

Query: 761  LLVVKMDGRKHRLILPEAKVQDSGEFEC--RTEGVSAFFG--VTVQDPPVHIVDPREHVF 816
               +        L + +    D+GE++C    EG S      V +++PP  I        
Sbjct: 5000 KYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTT 5059

Query: 817  VHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGE 876
            V  + S     +         + W KD Q ++E D V +        L + +      G 
Sbjct: 5060 V--LKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGR 5117

Query: 877  FQCVAGDECAY---FTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWT 932
            + C A +E      +   +    + IV  +  V V     + + L C +   P  +V+W 
Sbjct: 5118 YTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVT--EKDPMTLECVVAGTPELKVKWL 5175

Query: 933  KDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT----VTVTEPPV 988
            KDG+++V S    +  E+ V    + +V  +DSG+Y  +++++  S +    + V +  +
Sbjct: 5176 KDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNI 5235

Query: 989  RIIYPRDEVTLIAVTLECVVLMCELSRE-DAPVRWYKDGLEVEESEALVLERDGPRCRLV 1047
               + +    +  V    + + C++S       +W+KDG E+  S    L        L 
Sbjct: 5236 PPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLE 5295

Query: 1048 LPAAQPEDGGEFVCD----AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRC 1103
            +   + ED   + C     AGDD+    +TV  PP  +V P  +          +  L+ 
Sbjct: 5296 VNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILK- 5354

Query: 1104 EVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH----EA 1159
                   +++W+KD +E+ +     +G EG T  L L        G+Y C   +    ++
Sbjct: 5355 --GTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDS 5412

Query: 1160 ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP---VVWSHNGRPVQEG 1216
             T  +++ EPP     LE +     V  G+   L C++  AG+P   VVW  N   +   
Sbjct: 5413 CTTMLLVTEPPKFVKKLEASK---IVKAGDSSRLECKI--AGSPEIRVVWFRNEHELPAS 5467

Query: 1217 EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQ 1276
            +   +       V+ +       +G + C++    G+ S S  V V EPPV    P   +
Sbjct: 5468 DKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVE 5527

Query: 1277 TRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGD 1335
            T        ++ L   LSG P   V WYKD  +L S  + ++        + +    + D
Sbjct: 5528 T----LKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSD 5583

Query: 1336 AGEYLCDAP----QDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADV 1390
             GEY C A      D+ +  V ++EP   + VS+L  LTV  G+ A  +  +       V
Sbjct: 5584 IGEYHCKAQNEVGSDTCVCTVKLKEP--PRFVSKLNSLTVVAGEPAELQASIEGAQPIFV 5641

Query: 1391 TWLR-NGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR----AGSTATSARLHVR 1445
             WL+    V+     + +    +   L     +  +AG    +     G     A L V 
Sbjct: 5642 QWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVL 5701

Query: 1446 ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIH 1505
            E  ++ + +   +    G+   LE +        +V W + G+ L    +   +    I 
Sbjct: 5702 EPAVI-VEKAGPMTVTVGETCTLECKVAGTPEL-SVEWYKDGKLLTSSQKHKFSFYNKIS 5759

Query: 1506 RLFIHGVILADQGTYGCESHHD------RTLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
             L I  V   D GTY  +  ++        +  +S R       R L++     G S   
Sbjct: 5760 SLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCIL 5819

Query: 1560 QLELS-QEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSF-TAD 1614
            + +++    ++  W     ++  G K       +   L LN L  +D G   CV+   A 
Sbjct: 5820 ECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAG 5879

Query: 1615 SLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPR 1673
            S  C A L V+E P + V+ P  LEV  G   TF   +       V W +    L    R
Sbjct: 5880 SDECRAVLTVQE-PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDR 5938

Query: 1674 LRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVR---ERTVAVLSELRSVSA 1730
              +    T   L+L     S +G Y+C V    AG    T R   +   A L  L   S 
Sbjct: 5939 CNIYFEDTVAELELFNIDISQSGEYTCVVSN-NAGQASCTTRLFVKEPAAFLKRLSDHSV 5997

Query: 1731 REGDGATFECT-VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG--- 1786
              G     E T    +  +  W+  G  +    +  I    K  IL +      DAG   
Sbjct: 5998 EPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYS 6057

Query: 1787 -EVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG-HVCWLRE 1844
             E+  +AG     AL+     P  +    P E    VG    L+  V+ +    V W + 
Sbjct: 6058 CEIENEAGRDVCGALVSTLEPPYFVTELEPLE--AAVGDSVSLQCQVAGTPEITVSWYKG 6115

Query: 1845 GAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
              +L P  +Y         +LV + V   D G Y C+A
Sbjct: 6116 DTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKA 6153



 Score =  283 bits (725), Expect = 9e-76
 Identities = 451/1993 (22%), Positives = 724/1993 (36%), Gaps = 223/1993 (11%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP F++ P P+ V+ G       V+ G PP  V W +G ++L   +R +   +     L 
Sbjct: 5892 PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELE 5951

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            L     + +G Y C   N AG+A     + V EP A                       F
Sbjct: 5952 LFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAA-----------------------F 5988

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            L       V  G  ++L     G    ++ W+KDG  +      +    +          
Sbjct: 5989 LKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTE---------K 6039

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
            +  L IL +   D+G Y C   N  G    GAL+   +PP              +EPL+ 
Sbjct: 6040 TCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYF---------VTELEPLEA 6090

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY-- 308
            A        G     +C V G PE  + W+     L P      YR      V  +++  
Sbjct: 6091 A-------VGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPE---YRTYFTNNVATLVFNK 6140

Query: 309  CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRL--RFTRPLQDVEGREHGIAVLECKVPN 366
                D G Y C A NS G   S     ++E +L   F R L+D+E        L C++  
Sbjct: 6141 VNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNG 6200

Query: 367  SR-IPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE-------MRGRV 418
            S  I   W+R+   L      +      V  L I +      G Y C             
Sbjct: 6201 SAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSA 6260

Query: 419  RTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDGEEL---- 468
            R  A    K P     P  +DV+ GE+A       E  V G       WS+D +E+    
Sbjct: 6261 RLTAREPKKSPFFDIKPVSIDVIAGESA-----DFECHVTGAQPMRITWSKDNKEIRPGG 6315

Query: 469  --PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEM 526
               + C  ++ H+  L    V + D+G+ T    N     +   +     PP      E 
Sbjct: 6316 NYTITCVGNTPHLRIL---KVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEA 6372

Query: 527  FKGHK--NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFS-IEKAGAVEVPGDCVP 583
             K  K   ++ L  K    +PE    +     E+  E W    S I     + +      
Sbjct: 6373 SKVAKQGESIQLECK-ISGSPEIKVSWFRNDSEL-HESWKYNMSFINSVALLTINEASAE 6430

Query: 584  SEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI- 642
              GDY   IC    H          +  +            V    G D +   ++S   
Sbjct: 6431 DSGDY---IC--EAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTP 6485

Query: 643  -IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPG 701
              +  W  + +++++++          +++I  K     L +  ++  D G    + C  
Sbjct: 6486 PFEVVWVKDRKQVRNSK----------KFKITSKHFDTSLHILNLEASDVGE---YHCKA 6532

Query: 702  VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV-----DFPATWYKD-GQK 755
              +  + T   S V    P   V     TS  +    EL  +          W KD G+ 
Sbjct: 6533 TNEVGSDTCSCS-VKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEV 6591

Query: 756  VEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE---GVSAFFGVTVQDPPVHIVDPR 812
            + ESE   +        L L   +  +SG++ C+ +   G+     V     P  I++  
Sbjct: 6592 IRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKP 6651

Query: 813  EHVFV---HAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPAT 869
            E + V   +    ECV+        +   +W+KDG+E+       +        L +P  
Sbjct: 6652 EPMTVTTGNPFALECVV----TGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCA 6707

Query: 870  QPSDGGEFQCVAGDECAYFTVTIT-DVSSWIVYPS---GKVYVAAVRLERVVLTCELC-R 924
            + SD G +     +       T++  VS  IV PS       V A+    VVL C +   
Sbjct: 6708 EMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGS 6767

Query: 925  PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFT 980
                V W +DG E+V  P       + V  L L  ++  D+G Y C        +  S  
Sbjct: 6768 APISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAV 6827

Query: 981  VTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP--VRWYKDGLEVEESEALVLE 1038
            +TV EPP     P     L  ++L        + R   P  V+W+K   E+   E+  + 
Sbjct: 6828 LTVQEPPSFEQTPDSVEVLPGMSL----TFTSVIRGTPPFKVKWFKGSRELVPGESCNIS 6883

Query: 1039 RDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFG 1094
             +     L L   QP + G++ C    DAG  S    + V  P   +   A  S++   G
Sbjct: 6884 LEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVET--G 6941

Query: 1095 APGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
            +P  +E      P  S V W KD   +  S+   +     +  L +  +  ED  +Y C 
Sbjct: 6942 SPIVLEATYTGTPPIS-VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCL 7000

Query: 1155 TRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP---VVWS 1207
              +EA        V + EPP     LE   + +    GEP  L C++   G P   + W 
Sbjct: 7001 IENEAGQDICEALVSVLEPPYFIEPLEHVEAVI----GEPATLQCKVD--GTPEIRISWY 7054

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPV 1267
                 ++     ++  +     L I     +  G Y+C++  + GA + S  + +     
Sbjct: 7055 KEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI---KA 7111

Query: 1268 RVVAPEAAQ--TRVRSTPGGDLELVVHLSGPGG-PVRWYKDGERLASQGRVQLEQAGARQ 1324
            R + P  A+    V  T G  +     ++G     V WYKDG  L     +Q        
Sbjct: 7112 RKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVA 7171

Query: 1325 VLRVQGARSGDAGEYLCD-------APQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDA 1377
             L++        G+Y C        A   +++ L   E P    L      L +  G+  
Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLAL--GESG 7229

Query: 1378 TFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR---- 1432
            TF+C V+      +TW ++   + PG   +M    ++  LT+     GDAG  T      
Sbjct: 7230 TFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNI 7289

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVR--WVRGGQPL 1490
            AG  + SA+L V+E    F+++L+  R  + QD     E  ++G +  ++  W +    +
Sbjct: 7290 AGKDSCSAQLGVQEPP-RFIKKLEPSRIVK-QDEFTRYEC-KIGGSPEIKVLWYKDETEI 7346

Query: 1491 PHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH------DRTLARLSVRPRQLRVLR 1544
               S+  M+    +  L +H + + D G Y CE+H+        T  ++   P   +   
Sbjct: 7347 QESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPH 7406

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTG---EWARGGVQLYPGPKCHIHSDGHRHRLVLNGL 1601
            P+E +       A   LE   +G       W +   +L  G K  I S+     + +  +
Sbjct: 7407 PIETLK-----GADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNV 7461

Query: 1602 GLADSG---CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQA-LA 1657
              AD G   C +            I  + P   V+   D+    G     +  +  A   
Sbjct: 7462 DAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPI 7521

Query: 1658 DVTWEKD-GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGP----VRL 1712
             V W KD G  +  S  + +        LQ  R  P++AG Y+C +    AG       L
Sbjct: 7522 SVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKN-DAGMQECFATL 7580

Query: 1713 TVRERTVAVLSELRSVSAREGDGATFECTVSEV-ETTGRWELGGRPLRPGARVRIRQEGK 1771
            +V E    ++ +  S+    GD  T ECTV+   E + +W   G+ L    + +I    K
Sbjct: 7581 SVLE-PATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNK 7639

Query: 1772 KHILVLSELRAEDAG----EVRFQAGPAQSLALLEV--EALPLQMCRHPPREKTVLVGRR 1825
               L +  +   D+G    EV+   G     A L+V    +P    R   +E   L G  
Sbjct: 7640 VSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTR-KLKETNGLSGSS 7698

Query: 1826 AVLEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC---- 1880
             V+E  V  S    V W  EG E+  G KY+      T +L ++ +   D G Y C    
Sbjct: 7699 VVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATN 7758

Query: 1881 QAGQDSTHTRLLV 1893
             AG D     L V
Sbjct: 7759 MAGSDECSAPLTV 7771



 Score =  283 bits (723), Expect = 1e-75
 Identities = 253/1072 (23%), Positives = 449/1072 (41%), Gaps = 36/1072 (3%)

Query: 831  VDREDAPVRWYKDGQEVEESDFVVLE-NEGPHRRLVLPATQPSDGGEFQC----VAGDEC 885
            V + D    WYK+G ++E SD +     E     LV+      D          +AG+  
Sbjct: 2102 VGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETS 2161

Query: 886  AYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945
            ++  + +            +  VA  +       CE   P+ +V+W KDG EV E     
Sbjct: 2162 SHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYR 2221

Query: 946  LQKEDTVRRLVLPAVQLEDSGEYLCE-IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTL 1004
            +  +  V  L +  +   D+ +Y C  ++DE+   T  +      + + ++   +     
Sbjct: 2222 MHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPES 2281

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
                L C +S E+   +WY + +E++ +    +     R  L +     ED GE+     
Sbjct: 2282 YSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVID 2341

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
                   + +   P  I+   +   D        V+L  +V+    +  W KDG EV+ S
Sbjct: 2342 GKKTTCKLKMKPRPIAILQGLS---DQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPS 2398

Query: 1125 DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            D + +  +  +  L +     EDAG Y        ++ +  ++   V  +   T    + 
Sbjct: 2399 DRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVI---TPLKDVN 2455

Query: 1185 VAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLY 1243
            V  G   VL C++S      V W  N   ++  + ++   +G ++ L I     +  G Y
Sbjct: 2456 VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2515

Query: 1244 TCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWY 1303
                G      +LS         V  +        +  T   ++   V LS  G  V W 
Sbjct: 2516 KLIVGRVETNCNLS---------VEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2566

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLV 1363
               + +    + ++E  G    L V      D G+Y   A ++     ++V    + K  
Sbjct: 2567 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISK-- 2624

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQL 1423
              LT  TV E  +A F CEV+ PD+   WLR+G  +     +    +G  R L +   +L
Sbjct: 2625 -PLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKL 2683

Query: 1424 GDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRW 1483
             D G  T +  ++ TSA+L V   ++   + L+++   E QD    VE       G V+W
Sbjct: 2684 DDIGEYTYKVATSKTSAKLKVEAVKIK--KTLKNLTVTETQDAVFTVELTHPNVKG-VQW 2740

Query: 1484 VRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVL 1543
            ++ G  L  + + +++  G I+ L I    + D+  YG         ARL V    ++++
Sbjct: 2741 IKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET--VKII 2798

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            +  +DVT  E  +  F++ +S + V  +W    V++ P  K  + S+   H+L+L  +  
Sbjct: 2799 KKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISP 2858

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
            +D+G  +     L C A+L V  + +T  +   ++EV E  TA+FECE+S       W K
Sbjct: 2859 SDAGEYTAVVGQLECKAKLFVETLHIT--KTMKNIEVPETKTASFECEVSHFNVPSMWLK 2916

Query: 1664 DGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLS 1723
            +G  +  S + ++   G    L +      D+  Y+   G  +   V  T+    + + S
Sbjct: 2917 NGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQ---VSATLTVTPIMITS 2973

Query: 1724 ELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
             L+ ++A E D  TFE TV+    + +W   G  ++   + ++R +   H L +  +   
Sbjct: 2974 MLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFG 3033

Query: 1784 DAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLR 1843
            DA +  F AG A S A L VEA  ++  +H  ++  VL  +RA+ E  VS     V W++
Sbjct: 3034 DAADYTFVAGKATSTATLYVEARHIEFRKHI-KDIKVLEKKRAMFECEVSEPDITVQWMK 3092

Query: 1844 EGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
            +  EL   D+ +++     H L+I   R  D G Y   AG + +  +L VEG
Sbjct: 3093 DDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEG 3144



 Score =  278 bits (710), Expect = 5e-74
 Identities = 404/1933 (20%), Positives = 729/1933 (37%), Gaps = 206/1933 (10%)

Query: 43   VVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVL 102
            V+W    +++  S +    A G  + L +   +  D G Y       AGE   +  +TV 
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTF----YAGENMTSGKLTVA 2618

Query: 103  EPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWE 162
                S P                     LT    Q V    E V  C     P+    W 
Sbjct: 2619 GGAISKP---------------------LT---DQTVAESQEAVFECEVAN-PDSKGEWL 2653

Query: 163  KDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGA 222
            +DG          H  L      +  G    L I A +L D G Y          ++  A
Sbjct: 2654 RDG---------KHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVAT----SKTSA 2700

Query: 223  LLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWE 282
             L+V                     +K   K   V E + A F   +       ++W   
Sbjct: 2701 KLKVE-----------------AVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKN 2743

Query: 283  GRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLR 342
            G  +L    +     +   + L++  C   D  +Y        G+  ++ +LHV+   ++
Sbjct: 2744 G-VVLESNEKYAISVKGTIYSLRIKNCAIVDESVY----GFRLGRLGASARLHVE--TVK 2796

Query: 343  FTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRL 402
              +  +DV   E+     E  V +  +P  WF +   + P  K+  + E  V +L++  +
Sbjct: 2797 IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNI 2856

Query: 403  KADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWS 462
               D G Y   + G++   A + V+   + +  + ++V E + A    E     V   W 
Sbjct: 2857 SPSDAGEYTAVV-GQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSMWL 2915

Query: 463  RDGEELPVICQSS---SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
            ++G E+ +  +      G +H L++   + ED+ E TF  GN + +  L V  +  +   
Sbjct: 2916 KNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSML 2975

Query: 520  PPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPG 579
              I AE     K+T+  T++         + +     E+ S D  Q  + +   ++ +  
Sbjct: 2976 KDINAE----EKDTI--TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRN 3029

Query: 580  DCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDL 639
                   DY F    V+G   S   ++  + H+         ++D++V + + A+F  ++
Sbjct: 3030 VHFGDAADYTF----VAGKATSTATLYVEARHI----EFRKHIKDIKVLEKKRAMFECEV 3081

Query: 640  S-TIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFS 698
            S   I   W  + +EL+  +          R +I+++   HRL++ + +  D+G      
Sbjct: 3082 SEPDITVQWMKDDQELQITD----------RIKIQKEKYVHRLLIPSTRMSDAGKYT-VV 3130

Query: 699  CPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDG----Q 754
              G   +A L ++   V I S +  V +     +R V+  E++  D  A WYKDG     
Sbjct: 3131 AGGNVSTAKLFVEGRDVRIRSIKKEVQV--IEKQRAVVEFEVNEDDVDAHWYKDGIEINF 3188

Query: 755  KVEESELLVVKMDGRKHRLILPEAKVQDSGE--FECRTEGVSAFFGVTVQDPPVHIVDPR 812
            +V+E    VV  + R HR+ + E +  D+GE  F       S    V   +PP  ++   
Sbjct: 3189 QVQERHKYVV--ERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPP-QVLQEL 3245

Query: 813  EHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPS 872
            + V V +        A    R    + WYK+ Q +         ++G    L+L    P 
Sbjct: 3246 QPVTVQS-GKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3304

Query: 873  DGGEFQCVAGDE------CAYFTVTITDVSS----WIVYPSGKVY----VAAVRLERVVL 918
            D   + C A ++       A  +V + +V S      VYP   +           +    
Sbjct: 3305 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3364

Query: 919  TCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS 978
             C +     +V W    +++  S    + + +   +L +     ED G Y     +    
Sbjct: 3365 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3424

Query: 979  FTVTVT---EPPVRIIYPRDE----------------VTLIAVTL-ECVVLMCEL-SRED 1017
             + T     E P  I++ R E                +  + V L       CE+ S  +
Sbjct: 3425 VSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPN 3484

Query: 1018 APVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDD------SAFFT 1071
               +W+K G E+ ES+   +        L +   Q  D GE+ C A ++      +A  T
Sbjct: 3485 VRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLT 3544

Query: 1072 VTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
            VT   PP  +  P  +SL    G   +        P    + W KDG  +  S   ++  
Sbjct: 3545 VTEAYPPTFLSRP--KSLTTFVGKAAKFICTVTGTPVIETI-WQKDGAALSPSPNWRISD 3601

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETRH----EAITFNVILAEPPVQFLALETTPSPLCVAP 1187
                  L L +   +D G Y C+  +    +     +I+ + P     LE    P+  A 
Sbjct: 3602 AENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELE----PVQSAI 3657

Query: 1188 GEPVVLSCELSR-AGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQ 1246
             + V L C++       V WS +G+ +  G+  ++  E     L I  A    +G Y C 
Sbjct: 3658 NKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCT 3717

Query: 1247 SGAAPGAPSLSFTVQVAEPP--VRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWY 1303
            +    G+ S S TV V EPP  V+ V P          PG    L   L G P   V W+
Sbjct: 3718 ASNEAGSSSCSATVTVREPPSFVKKVDPSYLM-----LPGESARLHCKLKGSPVIQVTWF 3772

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLL 1359
            K+ + L+    V++    +  +L +   +  D+G Y C    D   DS    + ++EP  
Sbjct: 3773 KNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEP-- 3830

Query: 1360 VKLVSELTPLTVHEGDDATFRCEVSPPDA-DVTWLRNGAVVTPGPQVEMAQNGS---SRI 1415
               +  L P  +  G +A  +CEVS     +++W ++   +    +  +    S     I
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEI 3890

Query: 1416 LTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRV 1475
             +     +G+   V             H+ +    F++++ D+ A  GQ V L+    R 
Sbjct: 3891 FSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAV-RG 3949

Query: 1476 GAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC----ESHHDRTLA 1531
                +V W++G + +  D ++ M+    +  L I  V ++  G Y C    E+    ++ 
Sbjct: 3950 SEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVG 4009

Query: 1532 RLSVRPRQLRVLRPLEDVTISEGGSATFQLELS-QEGVTGEWARGGVQLYPGPKCHIHSD 1590
             L V+    +++   E + ++ G  AT +  ++    +  +W + G  L    K  I   
Sbjct: 4010 ELIVK-EPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFK 4068

Query: 1591 GHRHRLVLNGLGLADSGCVSFT------ADSLRCAARLIVREVPVTIVRGPHDLEVTEGD 1644
             +  +L      L DSG  +F       + S      ++ R++     +   +++     
Sbjct: 4069 NNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNG 4128

Query: 1645 TATFECELSQAL-ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC--- 1700
            T   +C+++ +L   V+W KDG  +  S R R+  +     L++ R   +DAG ++C   
Sbjct: 4129 TCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRAT 4188

Query: 1701 -AVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTV-SEVETTGRWELGGRPL 1758
             +VG+  +    +   +   + +++  S     G     + T       T RW  G + L
Sbjct: 4189 NSVGSKDSSGALIV--QEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKEL 4246

Query: 1759 RPGARVRIRQEGKKHILVLSELRAEDAG----EVRFQAGPAQSLALLEVEALPLQMCRHP 1814
              G    I +E  +  L L  ++  D+G    +V   AG  +  A L V+  P       
Sbjct: 4247 VSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE-PATFVEKL 4305

Query: 1815 PREKTVLVGRRAVLEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE 1873
               + +  G    L   V+ +    + W     E+    K+ M     T  L + DV  E
Sbjct: 4306 EPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIE 4365

Query: 1874 DQGTYCCQAGQDS 1886
            D G Y C+A  ++
Sbjct: 4366 DSGEYMCEAQNEA 4378



 Score =  275 bits (702), Expect = 4e-73
 Identities = 443/1995 (22%), Positives = 737/1995 (36%), Gaps = 226/1995 (11%)

Query: 7    DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
            D+   P F +  R V  V      L C + G  P  V W K G+++AAS+R         
Sbjct: 4108 DRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGT 4167

Query: 67   HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEG 126
              L +      DAG + CRA N+ G   ++ A+ V EPP+                    
Sbjct: 4168 ASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPS-------------------- 4207

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
               F+T P S+ VL G+ V L     G    T+ W K    L  V   S +  +      
Sbjct: 4208 ---FVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKEL--VSGGSCYITK------ 4256

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
                  +L +   +  DSG Y C   N  G  +  A L V +            PA  VE
Sbjct: 4257 -EALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE------------PATFVE 4303

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
             L+    +  + +G   +  C V G P  +I W    R +    +  M    +   VL++
Sbjct: 4304 KLE---PSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRM-SFVESTAVLRL 4359

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEG-REHGIAVLECKVP 365
                 +D G Y+C A+N AG    +  + VKE    FT+  + +E  +E+ + +L     
Sbjct: 4360 TDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPY-FTKEFKPIEVLKEYDVMLLAEVAG 4418

Query: 366  NSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT---VA 422
                   WF+++  L   RKY+   +  +  L I +  A D G Y C +   V +    A
Sbjct: 4419 TPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSA 4478

Query: 423  NVTVKGP--ILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSG 477
             VT++ P   +K++     +  G  A          +   W +D +E+     I  +   
Sbjct: 4479 RVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFEN 4538

Query: 478  HMHALVLPGVTREDAGEVTFSLGN----SRTTTLLRVK----------CVKHSPPGPPIL 523
            ++ +L L G+  +  G+      N     R + LL VK           +  +   P  L
Sbjct: 4539 NVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATL 4598

Query: 524  AEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVP 583
               F G K    +T K  +   E     + +     +   ++  S EK            
Sbjct: 4599 QVKFSGTKE---ITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEK-----------K 4644

Query: 584  SEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTII 643
              G+Y F +   +  GRS          L+        L+ +    G      +DL  I+
Sbjct: 4645 DSGEYTFEV--QNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGS----FIDLECIV 4698

Query: 644  QGT------WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGF 697
             G+      WF + +E+ ++E          +Y+         L +  ++  DSG    +
Sbjct: 4699 AGSHPISIQWFKDDQEISASE----------KYKFSFHDNTAFLEISQLEGTDSGT---Y 4745

Query: 698  SCPGV------QDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCEL-SRVDFPATWY 750
            +C         Q S  LT++E P  +  PQ   S     + RV L   +         W+
Sbjct: 4746 TCSATNKAGHNQCSGHLTVKEPPYFVEKPQ---SQDVNPNTRVQLKALVGGTAPMTIKWF 4802

Query: 751  KDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPV 806
            KD +++       V  D     L L  AK  DSG + C+        ++   + V++PP 
Sbjct: 4803 KDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQ 4862

Query: 807  HIVDPREHVFV---HAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRR 863
             I  P   + +    + T EC +      R    V WY DG E+       +        
Sbjct: 4863 FIKKPSPVLVLRNGQSTTFECQITGTPKIR----VSWYLDGNEITAIQKHGISFIDGLAT 4918

Query: 864  LVLPATQPSDGGEFQCVAGDECAYFTVTI-TDVSSWIVYPSGKVYVAAVRLERVVLTCEL 922
              +   +  + G + C A ++    + +I   V     +      V  V+   V L CE+
Sbjct: 4919 FQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEV 4978

Query: 923  C-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE----SA 977
               P  EV W K+  E+  S    L    +V  L +      D+GEY C + +E    S 
Sbjct: 4979 TGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSC 5038

Query: 978  SFTVTVTEPPVRIIYPRDEVTLI--AVTLECVVLMCELSREDAPVRWYKDGLEVEESEAL 1035
            S  V + EPP  I    +  T++  + T +  V           + W KD   ++E + +
Sbjct: 5039 STRVALKEPPSFIKKIENTTTVLKSSATFQSTV----AGSPPISITWLKDDQILDEDDNV 5094

Query: 1036 VLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAF---FTVTVTAPPERIVHPAARSLDLH 1092
             +        L + +      G + C A ++S     +   +   P +IV   A+S+D+ 
Sbjct: 5095 YISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVE-KAKSVDVT 5153

Query: 1093 FGAPGRVELRCEVAPAGS-QVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
               P  + L C VA     +V+W KDG ++  S    +  E    +  +     +D+G+Y
Sbjct: 5154 EKDP--MTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQY 5211

Query: 1152 VCETRHEAITFNVILAEPPVQFLALETTPS------PLCVAPGEPVVLSCELSRAGAPV- 1204
              +  ++   F     +  ++ L     PS       +    G  + + C++S    P+ 
Sbjct: 5212 TFKVEND---FGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVS-GSLPIS 5267

Query: 1205 -VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVA 1263
              W  +G+ +       L        L +          YTC+     G  + S  + V 
Sbjct: 5268 AQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK 5327

Query: 1264 EPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGA 1322
            EPP  +V P     R ++ P   +E    L G P   ++W+KD   L S  +  +   G+
Sbjct: 5328 EPPSFLVKP----GRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGS 5383

Query: 1323 RQVLRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSEL-TPLTVHEGDDA 1377
               L +    +   G+Y C    D   DS   ++ V EP   K V +L     V  GD +
Sbjct: 5384 TSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEP--PKFVKKLEASKIVKAGDSS 5441

Query: 1378 TFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR---- 1432
               C+++  P+  V W RN   +    +  M    S  ++ +      D+G         
Sbjct: 5442 RLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNP 5501

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
            AGST+ S ++ V+E   +F      V   +  +V LE E         V W +  + L  
Sbjct: 5502 AGSTSCSTKVIVKEPP-VFSSFPPIVETLKNAEVSLECELSGTPPFEVV-WYKDKRQLRS 5559

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH----DRTLARLSVRPRQLRVLRPLED 1548
              +  +A       + I  V  +D G Y C++ +    D  +  + ++    R +  L  
Sbjct: 5560 SKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLK-EPPRFVSKLNS 5618

Query: 1549 VTISEGGSATFQLEL-SQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG 1607
            +T+  G  A  Q  +   + +  +W +   ++         S+  R   V N   L  + 
Sbjct: 5619 LTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR------ESENIRITFVENVATLQFAK 5672

Query: 1608 CVSFTADSLRC-----------AARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QA 1655
                 A    C            A L+V E P  IV     + VT G+T T EC+++   
Sbjct: 5673 AEPANAGKYICQIKNDGGMRENMATLMVLE-PAVIVEKAGPMTVTVGETCTLECKVAGTP 5731

Query: 1656 LADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTARAGPVR 1711
               V W KDG  LT S + +         L++      DAGTY+      VG +    V 
Sbjct: 5732 ELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAV- 5790

Query: 1712 LTVRERTV--AVLSELRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVRIRQ 1768
            + V +R V  +    L++     G     EC V+     +  W      +  GA+ +   
Sbjct: 5791 VDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTF 5850

Query: 1769 EGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGR 1824
                  L L+ L + D G         AG  +  A+L V+  P  +    P E  VL G+
Sbjct: 5851 SDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLE--VLPGK 5908

Query: 1825 RAVLEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC--- 1880
                   +  +    V W R   EL  GD+  +        L + ++     G Y C   
Sbjct: 5909 NVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVS 5968

Query: 1881 -QAGQDSTHTRLLVE 1894
              AGQ S  TRL V+
Sbjct: 5969 NNAGQASCTTRLFVK 5983



 Score =  271 bits (694), Expect = 3e-72
 Identities = 257/1164 (22%), Positives = 461/1164 (39%), Gaps = 42/1164 (3%)

Query: 740  LSRVDFPATWYKDGQKVEESELLVVKM-DGRKHRLILPEAKVQDSGEFECRTEGV----S 794
            + + D    WYK+G K+E S+ +     +     L++ +   +DS     +   +    S
Sbjct: 2102 VGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETS 2161

Query: 795  AFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVV 854
            +   + VQ   +          V           CE       V+WYKDG EV E D   
Sbjct: 2162 SHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYR 2221

Query: 855  LENEGPHRRLVLPATQPSDGGEFQCV-AGDECAYFTVTITDVSSWIVYPSGKVYVAAVRL 913
            + ++     L +     SD  ++ CV   DE    T  +    + + +      +     
Sbjct: 2222 MHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPES 2281

Query: 914  ERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEID 973
                L C +     E +W  +  E+  +    +      + L +  V  ED GEY   ID
Sbjct: 2282 YSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVID 2341

Query: 974  DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESE 1033
             +  +  + +   P+ I+    +  +    +  V L  ++S E     W KDG EV+ S+
Sbjct: 2342 GKKTTCKLKMKPRPIAILQGLSDQKVCEGDI--VQLEVKVSLESVEGVWMKDGQEVQPSD 2399

Query: 1034 ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHF 1093
             + +  D     L++     ED G +           +  V+     ++ P     D++ 
Sbjct: 2400 RVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLK---DVNV 2456

Query: 1094 GAPGRVELRCEVA-PAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                +  L C+V+ P  + V+WY +  +++  D +Q   +G  + L +      D G Y 
Sbjct: 2457 IEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYK 2516

Query: 1153 CETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRP 1212
                      N+      V+ + +      L     + VV   ELS +G  V+W+   + 
Sbjct: 2517 LIVGRVETNCNL-----SVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKDKE 2571

Query: 1213 VQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
            ++     ++ A G    L +        G YT  +G    +  L+        P+     
Sbjct: 2572 IKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQTV 2631

Query: 1273 EAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
              +Q  V             ++ P     W +DG+ L     ++ E  G ++ L +   +
Sbjct: 2632 AESQEAV---------FECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATK 2682

Query: 1333 SGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDAD-VT 1391
              D GEY            + VE    VK+   L  LTV E  DA F  E++ P+   V 
Sbjct: 2683 LDDIGEYTYKVATSKTSAKLKVEA---VKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQ 2739

Query: 1392 WLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLF 1451
            W++NG V+    +  ++  G+   L ++ C + D      R G    SARLHV   +++ 
Sbjct: 2740 WIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVETVKII- 2798

Query: 1452 LRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHG 1511
             ++ +DV A E   V  EV          V+W      +    +  +  +  +H+L +  
Sbjct: 2799 -KKPKDVTALENATVAFEVSVSHDTVP--VKWFHKSVEIKPSDKHRLVSERKVHKLMLQN 2855

Query: 1512 VILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE 1571
            +  +D G Y          A+L V    L + + ++++ + E  +A+F+ E+S   V   
Sbjct: 2856 ISPSDAGEYTAVVGQLECKAKLFVET--LHITKTMKNIEVPETKTASFECEVSHFNVPSM 2913

Query: 1572 WARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTI 1631
            W + GV++    K  I   G  H+L++      DS   +F   + + +A L V   P+ I
Sbjct: 2914 WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTV--TPIMI 2971

Query: 1632 VRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCG 1691
                 D+   E DT TFE  ++       W K+G  +  + + +++       L +R   
Sbjct: 2972 TSMLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVH 3031

Query: 1692 PSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRW 1751
              DA  Y+   G A +    L V  R +     ++ +   E   A FEC VSE + T +W
Sbjct: 3032 FGDAADYTFVAGKATS-TATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQW 3090

Query: 1752 ELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMC 1811
                + L+   R++I++E   H L++   R  DAG+    AG   S A L VE   +++ 
Sbjct: 3091 MKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRI- 3149

Query: 1812 RHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELC--PGDKYEMRSHGPTHSLVIHD 1869
            R   +E  V+  +RAV+E  V+       W ++G E+     ++++       H + I +
Sbjct: 3150 RSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISE 3209

Query: 1870 VRPEDQGTYCCQAGQDSTHTRLLV 1893
             R  D G Y   AG++ +   L V
Sbjct: 3210 TRQSDAGEYTFVAGRNRSSVTLYV 3233



 Score =  269 bits (688), Expect = 2e-71
 Identities = 427/1942 (21%), Positives = 710/1942 (36%), Gaps = 258/1942 (13%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP F R  + V    G     +C + G  P  V W K G  L     L        H + 
Sbjct: 7115 PPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQ---TSFVHNVA 7171

Query: 71   LTAALPTDA---GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
                L TD    G Y C A N  G A ++A + + E                     E  
Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEH--------------------EVP 7211

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P F   P S  +  G      C   G     + W KD     E+    ++ +     E+ 
Sbjct: 7212 PFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNR---EIRPGGNYKMT--LVEN- 7265

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
               +  L +L     D+G Y C+A N  G     A L V +PP              +EP
Sbjct: 7266 ---TATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRF---------IKKLEP 7313

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
             +       V + +  ++ C + G PE ++ W+ +    + +  +      D   VL++ 
Sbjct: 7314 SRI------VKQDEFTRYECKIGGSPEIKVLWY-KDETEIQESSKFRMSFVDSVAVLEMH 7366

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS 367
                +D G Y C A N+AG   S+  L VKEP + F +    +E  +     LEC++  +
Sbjct: 7367 NLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPI-FRKKPHPIETLKGADVHLECELQGT 7425

Query: 368  R-IPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT---VAN 423
                 +W+++ + L   +KY+ + E  +  + I  + A D G Y C+    V +   V +
Sbjct: 7426 PPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGS 7485

Query: 424  VTVKGPILKRLPRKLDVLEGENAVLLVET-LEAGVEGR------WSRDGEEL----PVIC 472
            + +K P     PR +  L   + V+  E  L+  +EG       W +D  E+      I 
Sbjct: 7486 IALKAP-----PRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIW 7540

Query: 473  QSSSGHMHALVLPGVTREDAGEVTFSLGNSR-------TTTLLRVKCVKHSPPGPPILAE 525
             S S ++  L    V   +AG+ T  + N         T ++L    +   P    +   
Sbjct: 7541 ISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTG 7600

Query: 526  MFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSE 585
                 + TV  T       PE    +  + +E+ S++  +     K   +++        
Sbjct: 7601 DTCTLECTVAGT-------PELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDS 7653

Query: 586  GDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDL--STII 643
            G Y F +    G   S       S   VP +     L++     G   V    +  S  I
Sbjct: 7654 GVYSFEVQNPVGKD-SCTASLQVSDRTVPPS-FTRKLKETNGLSGSSVVMECKVYGSPPI 7711

Query: 644  QGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSG--ALVGFSCPG 701
              +WF  G E+ S            +Y+         L ++ ++  DSG    +  +  G
Sbjct: 7712 SVSWFHEGNEISSGR----------KYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAG 7761

Query: 702  VQD-SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD-FPATWYKDGQKVEES 759
              + SA LT++E P  +  P     LT T    V  T  +     F  +W+K   ++   
Sbjct: 7762 SDECSAPLTVREPPSFVQKPDPMDVLTGTN---VTFTSIVKGTPPFSVSWFKGSSELVPG 7818

Query: 760  ELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHA 819
            +   V ++     L L +     SGE+ C     +     T     ++I  P +  FV  
Sbjct: 7819 DRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTH---LYIKAPAK--FVKR 7873

Query: 820  ITSECVM----LACEVDREDAP---VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPS 872
            +    +     L  E      P   V W K+G  V  S    +        L +P++   
Sbjct: 7874 LNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVE 7933

Query: 873  DGGEFQC----VAGDECAYFTVTITDVSSWIVYPSG-KVYVAAVRLERVVLTCELC-RPW 926
            D G++ C     +G +     + I +   ++      KV V     +   L C+L   P 
Sbjct: 7934 DAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVG----DSASLQCQLAGTPE 7989

Query: 927  AEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE----SASFTVT 982
              V W K   ++  +    +   + V  LV   V + DSGEY+C+ ++     SAS  +T
Sbjct: 7990 IGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLT 8049

Query: 983  VTE---PPVRIIYPRDEVTLIAVTLECVVLMCELS-REDAPVRWYKDGLEVEESEAL--- 1035
            V E   PP      RD    + +    VV  C +S  E   V WYKDG  +++S  +   
Sbjct: 8050 VQEQKLPPSFSRQLRDVQETVGLP---VVFDCAISGSEPISVSWYKDGKPLKDSPNVQTS 8106

Query: 1036 ---------VLERDGP-----RCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERI 1081
                     + + D        C    P          +   G +  FF + + AP + +
Sbjct: 8107 FLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRL-APVDAV 8165

Query: 1082 VHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGLEVEASDALQLGAEGPTRTL 1138
            V  +A             +  C V   G+Q   V W KD  E+ +    Q+     +  L
Sbjct: 8166 VGESA-------------DFECHVT--GTQPIKVSWAKDSREIRSGGKYQISYLENSAHL 8210

Query: 1139 TLPHAQPEDAGEYVC----ETRHEAITFNVILAE---PPVQFLALETTPSPLCVAPGEPV 1191
            T+      D+G+Y C    E   ++ T  + + E   PP     L  T     V   E  
Sbjct: 8211 TVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSET-----VEETEGN 8265

Query: 1192 VLSCELSRAGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
                E   AG+    V W  N   +Q     E+  +    VL ++ AG   AGLYTC+  
Sbjct: 8266 SFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVS 8325

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVR--WYKDG 1306
               G+   + ++ + EP    V  +   T V  + G  ++L  H+ G   P+R  W K G
Sbjct: 8326 NDAGSALCTSSIVIKEPKKPPVFDQHL-TPVTVSEGEYVQLSCHVQG-SEPIRIQWLKAG 8383

Query: 1307 ERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAP----QDSRIFLVSVEEPLLVK- 1361
              +    R     A    VL ++     D+G+Y+C A      D+    V++++   V  
Sbjct: 8384 REIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAP 8443

Query: 1362 ------------LVSELTPLTVHEGDDATFRCEV-SPPDADVTWLR-NGAVVTPGPQVEM 1407
                         VSE   + V E   ATF  +V   P  +V W +     +  G +V +
Sbjct: 8444 ATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFI 8503

Query: 1408 AQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLFLRRLQ-----DV 1458
             Q G    L +R     D+G     A    G   ++  L V E      R+ Q     D+
Sbjct: 8504 HQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDE------RKKQEKIEGDL 8557

Query: 1459 RAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHD------------------SRLSMAQ 1500
            RA   +   L+   G       +  ++   P  ++                    L  +Q
Sbjct: 8558 RAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQ 8617

Query: 1501 DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ 1560
            +   HRL I  +  +++     E        RLS +   + +++ +E+ T+ +   A F+
Sbjct: 8618 EEETHRLEIEEIERSERDEKEFEELVSFIQQRLS-QTEPVTLIKDIENQTVLKDNDAVFE 8676

Query: 1561 LE--LSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRC 1618
            ++  ++   +   W +G  +L P  K  I  DG RH L +    L D G           
Sbjct: 8677 IDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIA 8736

Query: 1619 AARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQA 1678
            +A+L V  +     R   D+ + EG T T  C+ S       W ++G  L P  R + + 
Sbjct: 8737 SAKLTV--IEPAWERHLQDVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGRHKTEV 8794

Query: 1679 LGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATF 1738
                  L +      D G Y+C           L +    +     ++++   E   ATF
Sbjct: 8795 EHKVHKLTIADVRAEDQGQYTCKYEDLETS-AELRIEAEPIQFTKRIQNIVVSEHQSATF 8853

Query: 1739 ECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA-----G 1793
            EC VS  +    W  G   L    +   R +G+ H + +  +  +D G     A     G
Sbjct: 8854 ECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRG 8913

Query: 1794 PAQSLALLEVEALPLQMCRHPP 1815
             A+S A L +    +++   PP
Sbjct: 8914 EARSTAELYLTTKEIKLELKPP 8935



 Score =  260 bits (664), Expect = 1e-68
 Identities = 449/2015 (22%), Positives = 755/2015 (37%), Gaps = 272/2015 (13%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            P   +  P P+ V +G    L+CVV G P     W K G++L+A  +           L 
Sbjct: 6644 PARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLK 6703

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +  A  +D G+Y    +N+ G++    +V V            ++R +P        P F
Sbjct: 6704 IPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV------------SDRIVP--------PSF 6743

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +   +    + GA VVL CR  G    ++ W +DG  +      S    Q   +E+    
Sbjct: 6744 IRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEI-----VSGPKCQSSFSENVCTL 6798

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
            +L+L        D+G+Y C A N  G  +  A+L V +PP                  + 
Sbjct: 6799 NLSL----LEPSDTGIYTCVAANVAGSDECSAVLTVQEPPS----------------FEQ 6838

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
             P +  V  G    F   + G P  +++W    R L+P     +  + D    L++   Q
Sbjct: 6839 TPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLE-DFVTELELFEVQ 6897

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR-I 369
              + G Y C   N AG       L VKEP   F + L D         VLE     +  I
Sbjct: 6898 PLESGDYSCLVTNDAGSASCTTHLFVKEPAT-FVKRLADFSVETGSPIVLEATYTGTPPI 6956

Query: 370  PTAWFREDQRLLPCRKYE--QIEEGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVANV 424
              +W +++  +    +      E+ T+  ++   +  +D   Y C +    G+    A V
Sbjct: 6957 SVSWIKDEYLISQSERCSITMTEKSTILEILESTI--EDYAQYSCLIENEAGQDICEALV 7014

Query: 425  TVKGPILKRLPRKLDVLEGENAVL-LVETLEAGVEGR------WSRDGEEL---PVICQS 474
            +V  P     P  ++ LE   AV+    TL+  V+G       W ++  +L   P     
Sbjct: 7015 SVLEP-----PYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQ 7069

Query: 475  SSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTV 534
               ++ +LV+  V   D GE +    NS          V  +   PP  A   K    T+
Sbjct: 7070 FKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETL 7129

Query: 535  LLTWKPPEPAPETPFIYRLERQEVGSEDW------------IQCFSIEKAGAVEVPGDCV 582
                          F  R+   E     W            +Q   +     +++     
Sbjct: 7130 GFP---------VAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQ 7180

Query: 583  PSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYD-----GEDAVFSL 637
               G Y    C+ S    +P      SA L+ +   V    D++        GE   F  
Sbjct: 7181 SHIGQYN---CSAS----NPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKC 7233

Query: 638  DLSTI--IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALV 695
             ++    I+ TW  +  E++         PG   Y++        L +  V   D+G   
Sbjct: 7234 HVTGTAPIKITWAKDNREIR---------PGG-NYKMTLVENTATLTVLKVGKGDAGQYT 7283

Query: 696  GFSC--PGVQD-SAALTIQESPVHI--LSPQDRVSLT-FTTSERVVLTCELS-RVDFPAT 748
             ++    G    SA L +QE P  I  L P   V    FT  E     C++    +    
Sbjct: 7284 CYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYE-----CKIGGSPEIKVL 7338

Query: 749  WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDP 804
            WYKD  +++ES    +        L +    V+DSG++ C         S+   + V++P
Sbjct: 7339 WYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEP 7398

Query: 805  PVHIVDPREHVFVHAITSECVMLACEVDREDA-PVRWYKDGQEVEESDFVVLENEGPHRR 863
            P+    P     +  +    V L CE+       V WYKD +E+       + +E     
Sbjct: 7399 PIFRKKPHP---IETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTS 7455

Query: 864  LVLPATQPSDGGEFQC-----VAGDECA---------YFTVTITDVSSWIVYPSGKVYVA 909
            + +     +D GE+QC     V  D C           F   ++D+S+ +    GK    
Sbjct: 7456 IHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVV----GK---- 7507

Query: 910  AVRLERVVLTCELCRPWAEVRWTKD-GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
             V+L+    T E   P + V W KD GE V ES  + +   + +  L    V+  ++G+Y
Sbjct: 7508 EVQLQT---TIEGAEPISVV-WFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKY 7563

Query: 969  LCEIDDESAS----FTVTVTEPPVRIIYPRD--EVTLIAVTLECVVLMCELSREDAPVRW 1022
             C+I +++       T++V EP   +  P      T    TLEC V        +   +W
Sbjct: 7564 TCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVA----GTPELSTKW 7619

Query: 1023 YKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTAPP 1078
            +KDG E+       +        L +    P D G +  +     G DS   ++ V+   
Sbjct: 7620 FKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVS--- 7676

Query: 1079 ERIVHPA-ARSLDLHFGAPGR-VELRCEVAPAGS-QVRWYKDGLEVEASDALQLGAEGPT 1135
            +R V P+  R L    G  G  V + C+V  +    V W+ +G E+ +    Q      T
Sbjct: 7677 DRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNT 7736

Query: 1136 RTLTLPHAQPEDAGEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPV 1191
              LT+   +  D+G+Y C   + A     +  + + EPP    +    P P+ V  G  V
Sbjct: 7737 CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPP----SFVQKPDPMDVLTGTNV 7792

Query: 1192 VLSCELSRAGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
              +  +   G P   V W      +  G+   +  E     L +     + +G YTC   
Sbjct: 7793 TFTSIVK--GTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVS 7850

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGP---VRWYKD 1305
               G  S +  + + + P + V      +  +  P     L++  +  G P   V W K+
Sbjct: 7851 NEAGKASCTTHLYI-KAPAKFVKRLNDYSIEKGKP-----LILEGTFTGTPPISVTWKKN 7904

Query: 1306 GERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC-----DAPQDSRIFLVSVEEPLLV 1360
            G  +    R  +       +L +  +   DAG+Y C              ++ +E P  V
Sbjct: 7905 GINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFV 7964

Query: 1361 KLVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLR 1419
            K   +L P+ V  GD A+ +C+++  P+  V+W +    + P    +M    +   L   
Sbjct: 7965 K---QLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFN 8021

Query: 1420 GCQLGDAGTVTLRA----GSTATSARLHVRETEL--LFLRRLQDVRAEEGQDVCLEVETG 1473
               + D+G    +A    G  + S  L V+E +L   F R+L+DV+   G  V  +    
Sbjct: 8022 QVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAIS 8081

Query: 1474 RVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARL 1533
                  +V W + G+PL     +  +   +   L I     +  G Y C + +    A  
Sbjct: 8082 GSEPI-SVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASS 8140

Query: 1534 SVRPRQLRVLRP------LEDVTISEGGSATFQLELS-QEGVTGEWARGGVQLYPGPKCH 1586
            S R        P      L  V    G SA F+  ++  + +   WA+   ++  G K  
Sbjct: 8141 SARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQ 8200

Query: 1587 IHSDGHRHRLVLNGLGLADSGCVSFTA------DSLRCAARLIVRE---VPVTIVRGPHD 1637
            I    +   L +  +   DSG  +  A      DS  C A+L ++E    P    R    
Sbjct: 8201 ISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDS--CTAQLNIKERLIPPSFTKRLSET 8258

Query: 1638 LEVTEGDTATFECEL--SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
            +E TEG++   E  +  SQ +  V W K+   + P+    +       +LQ+R+ G +DA
Sbjct: 8259 VEETEGNSFKLEGRVAGSQPIT-VAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDA 8317

Query: 1696 GTYSCAVGTARAGPV---RLTVRE--RTVAVLSELRSVSAREGDGATFECTVSEVETTG- 1749
            G Y+C V       +    + ++E  +       L  V+  EG+     C V   E    
Sbjct: 8318 GLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRI 8377

Query: 1750 RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ----AGPAQSLALLEVEA 1805
            +W   GR ++P  R          +L L ++   D+G+   +    AG   + + + ++ 
Sbjct: 8378 QWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKD 8437

Query: 1806 LPLQMCRHPPREKTVLVGR----------RAVLEVT---VSRSGG----HVCWLR-EGAE 1847
             P      P  +K  + GR          R V + T   +++ GG    +V W + +  +
Sbjct: 8438 KPAVA---PATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQ 8494

Query: 1848 LCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
            L  G +  +   G    L I D    D G Y C A
Sbjct: 8495 LNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVA 8529



 Score =  250 bits (638), Expect = 1e-65
 Identities = 427/1953 (21%), Positives = 726/1953 (37%), Gaps = 233/1953 (11%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERL--SFPADGAEHGLLLTAALPTDAG 80
            V  G++A  +  V+G+P P   W K G ++  S+R+   +P D     L++      D+ 
Sbjct: 2089 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCE-LVIRDVTAEDSA 2147

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
              + +A N AGE  + A + V                           +  T      V 
Sbjct: 2148 SIMVKAINIAGETSSHAFLLVQAKQL----------------------ITFTQELQDVVA 2185

Query: 141  RGAEVVLT--CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            +  + + T  C     P   + W KDGM   EV +   + +   R          L IL 
Sbjct: 2186 KEKDTMATFECETSE-PFVKVKWYKDGM---EVHEGDKYRMHSDRKVH------FLSILT 2235

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN 258
                D+  Y C             L++      +     + A    V+ L    +   V 
Sbjct: 2236 IDTSDAEDYSC------------VLVEDENVKTTAKLIVEGAVVEFVKEL----QDIEVP 2279

Query: 259  EGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
            E    +  C V   PE  IE  W    + L    +     R G   L V     +D+G Y
Sbjct: 2280 ESYSGELECIV--SPE-NIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEY 2336

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
                        +  +L +K   +   + L D +  E  I  LE KV    +   W ++ 
Sbjct: 2337 SFVIDGKK----TTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDG 2392

Query: 378  QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL-------CEMRGRVRTVANVTVKGPI 430
            Q + P  +   + +     L+I  +  +D G Y            GRV +V +V V  P+
Sbjct: 2393 QEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRV-SVYSVDVITPL 2451

Query: 431  LKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPV---ICQSSSGHMHALVLPG 486
                 + ++V+EG  AVL  +     V   +W  + E++     +     G    LV+  
Sbjct: 2452 -----KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 2506

Query: 487  VTREDAGEVTFSLGNSRTTTLLRVKCVK--------HSPPGPPILAEMFKGHKN-TVLLT 537
                D G     +G   T   L V+ +K               ++ E+   H    VL  
Sbjct: 2507 THASDEGPYKLIVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2566

Query: 538  WKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
            +K  E  P +   Y++E              I K   + +  D    EG Y F       
Sbjct: 2567 FKDKEIKPSSK--YKIEAHG----------KIYKLTVLNMMKD---DEGKYTF---YAGE 2608

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLST-IIQGTWFLNGEELKS 656
            +  S  +   G A   P       L D  V + ++AVF  +++    +G W  +G+ L  
Sbjct: 2609 NMTSGKLTVAGGAISKP-------LTDQTVAESQEAVFECEVANPDSKGEWLRDGKHL-- 2659

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVH 716
                    P     R E  G + RLI+ A K  D G    +     + SA L ++   + 
Sbjct: 2660 --------PLTNNIRSESDGHKRRLIIAATKLDDIGEYT-YKVATSKTSAKLKVEAVKI- 2709

Query: 717  ILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLIL 775
                +   +LT T ++  V T EL+  +     W K+G  +E +E   + + G  + L +
Sbjct: 2710 ---KKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI 2766

Query: 776  PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
                + D   +  R   + A   + V+   + I  P++   V A+ +  V     V  + 
Sbjct: 2767 KNCAIVDESVYGFRLGRLGASARLHVETVKI-IKKPKD---VTALENATVAFEVSVSHDT 2822

Query: 836  APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-ECA----YFTV 890
             PV+W+    E++ SD   L +E    +L+L    PSD GE+  V G  EC       T+
Sbjct: 2823 VPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL 2882

Query: 891  TITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKED 950
             IT     I  P  K              CE+        W K+G E+  S    +  + 
Sbjct: 2883 HITKTMKNIEVPETKT---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQG 2933

Query: 951  TVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM 1010
             + +L++     EDS EY     ++  S T+TVT  P+ I     ++   A   + +   
Sbjct: 2934 KLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVT--PIMITSMLKDIN--AEEKDTITFE 2989

Query: 1011 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 1070
              ++ E    +W K+G+E++ ++   +        L +      D  ++   AG  ++  
Sbjct: 2990 VTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTA 3049

Query: 1071 TVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
            T+ V A   R +       D+      R    CEV+     V+W KD  E++ +D +++ 
Sbjct: 3050 TLYVEA---RHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQ 3106

Query: 1131 AEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEP 1190
             E     L +P  +  DAG+Y         T  + +    V+  +++     + V   + 
Sbjct: 3107 KEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIK---KEVQVIEKQR 3163

Query: 1191 VVLSCELSRAGAPVVWSHNGRPV--QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
             V+  E++       W  +G  +  Q  E  +   E     + I     + AG YT  +G
Sbjct: 3164 AVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAG 3223

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGE 1307
                  S++  V   EPP   V  E     V+S  G        +SG P   + WYK+ +
Sbjct: 3224 R--NRSSVTLYVNAPEPP--QVLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKEEQ 3277

Query: 1308 RLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL----VSVEEPLLVK-- 1361
             L++  + +    G    L +  A   DA  Y C+A  D  +      +SVE P +V   
Sbjct: 3278 LLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPD 3337

Query: 1362 ---------LVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGS 1412
                     +++ L      EG  A F+C VS  D  V+W      + P     M Q   
Sbjct: 3338 QEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFED 3397

Query: 1413 SRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLFLRRL-QDVRAE------ 1461
            +  L +      D GT T  A    G  +++A L +   E +   R+ Q++  E      
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPV 3457

Query: 1462 -EGQDVCLEVETG-------RVGAAGAVR--WVRGGQPLPHDSRLSMAQDGHIHRLFIHG 1511
             + +   LEV  G        + +A  VR  W + G+ +    + S+    +I  L I  
Sbjct: 3458 IKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILR 3517

Query: 1512 VILADQGTYGCESHHD-------RTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELS 1564
              + D G Y C++ ++        TL      P    + RP + +T   G +A F   ++
Sbjct: 3518 TQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTF-LSRP-KSLTTFVGKAAKFICTVT 3575

Query: 1565 QEGVTGE-WARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSL----RCA 1619
               V    W + G  L P P   I    ++H L L+ L + D G  S  A +      C 
Sbjct: 3576 GTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQ 3635

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQA 1678
            A LI+ + P   ++    ++         EC++ +     VTW KDG  L P    ++  
Sbjct: 3636 AELIIIDKP-HFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICF 3694

Query: 1679 LGTRRLLQLRRCGPSDAGTYSCAVGT---ARAGPVRLTVRERTVAVLSELRSVSAREGDG 1735
                  L++      D+GTY C       + +    +TVRE    V     S     G+ 
Sbjct: 3695 EDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGES 3754

Query: 1736 ATFECTVS---EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA 1792
            A   C +     ++ T  W    + L     VR+     + IL +++++ ED+G    +A
Sbjct: 3755 ARLHCKLKGSPVIQVT--WFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEA 3812

Query: 1793 ----GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG-HVCWLREGAE 1847
                G       + ++  P  +    P +  ++ G  A+L+  VS +G   + W ++  +
Sbjct: 3813 VNDVGSDSCSTEIVIKEPPSFIKTLEPAD--IVRGTNALLQCEVSGTGPFEISWFKDKKQ 3870

Query: 1848 LCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC 1880
            +    KY + S      L I      D G Y C
Sbjct: 3871 IRSSKKYRLFSQKSLVCLEIFSFNSADVGEYEC 3903



 Score =  246 bits (628), Expect = 2e-64
 Identities = 447/2002 (22%), Positives = 729/2002 (36%), Gaps = 236/2002 (11%)

Query: 7    DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
            D+  PP F R  +    V GA   L+C V G  P  V W     ++ +  +         
Sbjct: 5795 DRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNV 5854

Query: 67   HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEG 126
              L L +   +D G Y C A N AG     A +TV EPP+   E +P E           
Sbjct: 5855 CTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLE----------- 5903

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
                        VL G  V  T    G P   + W +    L +  D  +   +   AE 
Sbjct: 5904 ------------VLPGKNVTFTSVIRGTPPFKVNWFRGARELVK-GDRCNIYFEDTVAE- 5949

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
                   L +    +  SG Y C   N  G A     L V +P        D +    VE
Sbjct: 5950 -------LELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHS----VE 5998

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
            P            GK         G     + W  +G  +    +  +    +   +L++
Sbjct: 5999 P------------GKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIV-TTEKTCILEI 6045

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            L    +D G Y C   N AG+ +    +   EP   F   L+ +E        L+C+V  
Sbjct: 6046 LNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPY-FVTELEPLEAAVGDSVSLQCQVAG 6104

Query: 367  S-RIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
            +  I  +W++ D +L P  +Y       V  L+ +++  +D G Y C+    + T ++ T
Sbjct: 6105 TPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKT 6164

Query: 426  VKGPILKRLPRKL--DVLEGENAVLLVETLEAGVEGR------WSRDGEEL---PVICQS 474
            V     ++LP      + + E  V L  TL   + G       W RDG  L     +  S
Sbjct: 6165 VFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTS 6224

Query: 475  SSGHMHALVLPGVTREDAGEVTFS----LGNSRTTTLLRVKCVKHSP--PGPPILAEMFK 528
               ++  L +       +G+ + S    LG + ++  L  +  K SP     P+  ++  
Sbjct: 6225 FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIA 6284

Query: 529  GHKNTVLLTWKPPEPAPETPFIYRLERQEV--GSEDWIQC------FSIEKAGAVEVPGD 580
            G            +P   T   +  + +E+  G    I C        I K G  +    
Sbjct: 6285 GESADFECHVTGAQPMRIT---WSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQY 6341

Query: 581  CVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQV-YDGEDAVFSLDL 639
               +  D    +C+     + P              + V  LE  +V   GE    S+ L
Sbjct: 6342 TCQATNDVGKDMCSAQLSVKEP-------------PKFVKKLEASKVAKQGE----SIQL 6384

Query: 640  STIIQGT------WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGA 693
               I G+      WF N  EL            + +Y +        L ++    +DSG 
Sbjct: 6385 ECKISGSPEIKVSWFRNDSELHE----------SWKYNMSFINSVALLTINEASAEDSGD 6434

Query: 694  LVGFSCPGVQD---SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV-DFPATW 749
             +  +  GV D   S ALT++  PV    P    +L       V+L CE+S    F   W
Sbjct: 6435 YICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGAL---KGSDVILQCEISGTPPFEVVW 6491

Query: 750  YKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDPP 805
             KD ++V  S+   +        L +   +  D GE+ C+        +    V  ++PP
Sbjct: 6492 VKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPP 6551

Query: 806  VHIVDPREHVFVHAITSECVMLACEVDR-EDAPVRWYKD-GQEVEESDFVVLENEGPHRR 863
              +   ++      +  + V L   V+  +   V W KD G+ + ES+   +        
Sbjct: 6552 RFV---KKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIAT 6608

Query: 864  LVLPATQPSDGGEFQCV----AGDECAYFTVTITDVSSWIVYPSGKVYVAA--VRLERVV 917
            L L + + S+ G++ C     AG       +T+ + +  I  P            LE VV
Sbjct: 6609 LQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVV 6668

Query: 918  LTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESA 977
                   P    +W KDG E+       +   + V  L +P  ++ D G Y  E+ +   
Sbjct: 6669 TG----TPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVG 6724

Query: 978  SFTVTVT-EPPVRIIYP---RDEVTLIAVTLECVVLMCELSREDAP--VRWYKDGLEVEE 1031
                TV+     RI+ P   R    + A+    VVL C +S   AP  V W++DG E+  
Sbjct: 6725 KSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVS-GSAPISVGWFQDGNEIVS 6783

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAAR 1087
                        C L L   +P D G + C     AG D     +TV  PP     P + 
Sbjct: 6784 GPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSV 6843

Query: 1088 SLDLHFGAPGRVELRCEVAPAGS---QVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQ 1144
             +      PG + L       G+   +V+W+K   E+   ++  +  E     L L   Q
Sbjct: 6844 EV-----LPG-MSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQ 6897

Query: 1145 PEDAGEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 1200
            P ++G+Y C   ++A     T ++ + EP      L    +   V  G P+VL  E +  
Sbjct: 6898 PLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRL----ADFSVETGSPIVL--EATYT 6951

Query: 1201 GAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLS 1257
            G P   V W  +   + + E   +       +L I  +       Y+C      G     
Sbjct: 6952 GTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICE 7011

Query: 1258 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQ 1316
              V V EPP  +   E     V +  G    L   + G P   + WYK+  +L S    +
Sbjct: 7012 ALVSVLEPPYFIEPLE----HVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYK 7067

Query: 1317 LEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPL------T 1370
            ++       L +      D GEY C A  D+ +  V+    L++K   +L P        
Sbjct: 7068 MQFKNNVASLVINKVDHSDVGEYSCKA--DNSVGAVASSAVLVIK-ARKLPPFFARKLKD 7124

Query: 1371 VHE--GDDATFRCEVSPPD-ADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAG 1427
            VHE  G    F C ++  +   V+W ++G ++     ++ +   +   L +        G
Sbjct: 7125 VHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIG 7184

Query: 1428 TVTLRA----GSTATSARLHVRETELLFLRRLQDVR-----AEEGQDVCLEVETGRVGAA 1478
                 A    G+ ++SA+L + E E+     L+ V       E G   C    T  +   
Sbjct: 7185 QYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPI--- 7241

Query: 1479 GAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH----DRTLARLS 1534
              + W +  + +       M    +   L +  V   D G Y C + +    D   A+L 
Sbjct: 7242 -KITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLG 7300

Query: 1535 VR--PRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGH 1592
            V+  PR ++ L P   V   E      ++  S E +   W +   ++    K  +     
Sbjct: 7301 VQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPE-IKVLWYKDETEIQESSKFRMSFVDS 7359

Query: 1593 RHRLVLNGLGLADSG---CVSF-TADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATF 1648
               L ++ L + DSG   C +   A S   +  L V+E P+   + PH +E  +G     
Sbjct: 7360 VAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPI-FRKKPHPIETLKGADVHL 7418

Query: 1649 ECELSQALA-DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA----VG 1703
            ECEL       V+W KD   L    + ++ +      + +     +D G Y C     VG
Sbjct: 7419 ECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVG 7478

Query: 1704 T-ARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVE--TTGRWELGGRPLRP 1760
            +    G + L    R V  LS++ +V  +E      + T+   E  +   ++  G  +R 
Sbjct: 7479 SDTCVGSIALKAPPRFVKKLSDISTVVGKE---VQLQTTIEGAEPISVVWFKDKGEIVRE 7535

Query: 1761 GARVRIRQEGKKHILVLSELRAEDAG----EVRFQAGPAQSLALLEVEALPLQMCRHPPR 1816
               + I        L  S +   +AG    +++  AG  +  A L V  L        P 
Sbjct: 7536 SDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV--LEPATIVEKPE 7593

Query: 1817 EKTVLVGRRAVLEVTVSRSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQ 1875
               V  G    LE TV+ +      W ++G EL   +KY++        L I +V P D 
Sbjct: 7594 SIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDS 7653

Query: 1876 GTYCCQ----AGQDSTHTRLLV 1893
            G Y  +     G+DS    L V
Sbjct: 7654 GVYSFEVQNPVGKDSCTASLQV 7675



 Score =  223 bits (569), Expect = 1e-57
 Identities = 392/1776 (22%), Positives = 676/1776 (38%), Gaps = 221/1776 (12%)

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
            K   V E K A F C V  +P+  ++W  + + L    R  + +++   +V ++L    +
Sbjct: 3065 KDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEK---YVHRLLIPSTR 3120

Query: 313  --DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP 370
              D G Y   A    G  +S  +L V+   +R     ++V+  E   AV+E +V    + 
Sbjct: 3121 MSDAGKYTVVA----GGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVD 3176

Query: 371  TAWFRE--DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKG 428
              W+++  +       +++ + E  + R+ I   +  D G Y   + GR R+   + V  
Sbjct: 3177 AHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTF-VAGRNRSSVTLYVNA 3235

Query: 429  P----ILKRLPRKLDVLEGENAVLLV----------------ETLEAGVEGRWSRDGEEL 468
            P    +L+ L + + V  G+ A                    + L  G + ++  DG+E 
Sbjct: 3236 PEPPQVLQEL-QPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY 3294

Query: 469  PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFK 528
             ++   +     A V     + D G  T S   S     + V   +  P  PP +    +
Sbjct: 3295 TLLLIEAFPE-DAAVYTCEAKNDYGVATTSASLSVEVPEV-VSPDQEMPVYPPAIITPLQ 3352

Query: 529  GHKNTVLLTWKPPE-----PAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVP 583
               +TV    +P          +    +  + +++    + +    E    +E+      
Sbjct: 3353 ---DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPE 3409

Query: 584  SEGDYRFRICTVSGHGRS--------PHVVFHGSAHLVPTARLVAG------LEDVQVYD 629
             EG Y F      G   S        P  + H          + A       +E ++V  
Sbjct: 3410 DEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVAL 3469

Query: 630  GEDAVFSLDLSTI--IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVK 687
            G  A F+ ++ +   ++  WF  G E+  ++          +  I        L +   +
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGREIYESD----------KCSIRSSKYISSLEILRTQ 3519

Query: 688  HQDSGALVGFSCPG------VQDSAALTIQES--PVHILSPQDRVSLTFTTSERVVLTCE 739
              D G    ++C        V  +A LT+ E+  P  +  P+   SLT    +     C 
Sbjct: 3520 VVDCGE---YTCKASNEYGSVSCTATLTVTEAYPPTFLSRPK---SLTTFVGKAAKFICT 3573

Query: 740  LSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFG 798
            ++      T W KDG  +  S    +     KH L L    +QD G + C+    S  FG
Sbjct: 3574 VTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKA---SNKFG 3630

Query: 799  VTVQDPPVHIVDP----REHVFVHAITSECVMLACEVDRE-DAPVRWYKDGQEVEESDFV 853
              +    + I+D     +E   V +  ++ V L C+VD +    V W KDGQ++      
Sbjct: 3631 ADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDY 3690

Query: 854  VLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYF----TVTITDVSSWIVYPSGKVYVA 909
             +  E     L +P  +  D G + C A +E        TVT+ +  S++     KV  +
Sbjct: 3691 KICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVK----KVDPS 3746

Query: 910  AVRL--ERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSG 966
             + L  E   L C+L   P  +V W K+ +E+ ES  + +   ++   L +  V++EDSG
Sbjct: 3747 YLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSG 3806

Query: 967  EYLCE----IDDESASFTVTVTEPP--VRIIYPRDEVTLIAVTLECVVLMCELSREDAPV 1020
             Y CE    +  +S S  + + EPP  ++ + P D V      L+C V           +
Sbjct: 3807 SYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVS----GTGPFEI 3862

Query: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTA 1076
             W+KD  ++  S+   L        L + +    D GE+ C    + G      T  +  
Sbjct: 3863 SWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKE 3922

Query: 1077 PPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGLEVEASDALQLGAEG 1133
            PP  +     + +D      G+  +  + A  GS+   V W K    +     +++    
Sbjct: 3923 PPTFV-----KKVDDLIALGGQT-VTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSN 3976

Query: 1134 PTRTLTLPHAQPEDAGEYVCETRHEA---ITFNVILAEPPVQFLALETTPSPLCVAPGEP 1190
                L +P  Q    G+Y C   +EA    +   ++ + P + +        + V  G+P
Sbjct: 3977 GVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAEL---IQVTAGDP 4033

Query: 1191 VVLSCELSRAGAPVV---WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
              L  E + AG P +   W  +GRP+   +   +  +     L   +A    +G YT + 
Sbjct: 4034 ATL--EYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEI 4091

Query: 1248 GAAPGAPSLSFTVQVAEPPVRVVAPEAAQT--RVRSTPGGDLELVVHLSGPGGPVR--WY 1303
                G+ S   T  V +   R +AP   +    V S   G   L   ++G   P+R  W+
Sbjct: 4092 SNEVGSSSCETTFTVLD---RDIAPFFTKPLRNVDSVVNGTCRLDCKIAG-SLPMRVSWF 4147

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAP-----QDSRIFLVSVEEPL 1358
            KDG+ +A+  R ++        L +      DAG + C A      +DS   L+  E P 
Sbjct: 4148 KDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPP- 4206

Query: 1359 LVKLVSELTPLTVHEGDDATFRC--EVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRIL 1416
                V++     V  G     +   + S P   + W +    +  G    + +      L
Sbjct: 4207 --SFVTKPGSKDVLPGSAVCLKSTFQGSTP-LTIRWFKGNKELVSGGSCYITKEALESSL 4263

Query: 1417 TLRGCQLGDAGTVTLR----AGSTATSARLHVRETELLFLRRLQDV----RAEEGQDVCL 1468
             L   +  D+GT T +    AG    SA L V+E    F+ +L+      + +  Q  C 
Sbjct: 4264 ELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPAT-FVEKLEPSQLLKKGDATQLACK 4322

Query: 1469 EVETGRVGAAGAVRWVRGGQPLPHDS--RLSMAQDGHIHRLFIHGVILADQGTYGCE--- 1523
               T  +     + W    + +   S  R+S  +   + RL   G+   D G Y CE   
Sbjct: 4323 VTGTPPI----KITWFANDREIKESSKHRMSFVESTAVLRLTDVGI--EDSGEYMCEAQN 4376

Query: 1524 ---SHHDRTLARLSVRPRQLRVLRPLE-----DVTISEGGSATFQLELSQEGVTGEWARG 1575
               S H  ++  +   P   +  +P+E     DV +    + T   E++       W + 
Sbjct: 4377 EAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEIT-------WFKD 4429

Query: 1576 GVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG---C-VSFTADSLRCAARLIVREVPVTI 1631
               L  G K       H   L +     AD+G   C V+    S  C+AR+ +RE P + 
Sbjct: 4430 NTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPP-SF 4488

Query: 1632 VRGPHDLEVTEGDTATFECELSQALA-DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRC 1690
            ++         G TA F+  L  +L   VTW KD + +T    +R+        L L   
Sbjct: 4489 IKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGI 4548

Query: 1691 GPSDAGTYSCAV----GTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEV- 1745
                 G Y C      G  R   + L+V+E    +  E  S+   +GD AT +   S   
Sbjct: 4549 EVKHDGKYVCQAKNDAGIQRCSAL-LSVKE-PATITEEAVSIDVTQGDPATLQVKFSGTK 4606

Query: 1746 ETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRF--QAGPAQSLALLEV 1803
            E T +W   G+ L  G++ +I       IL +     +D+GE  F  Q    +S     +
Sbjct: 4607 EITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARI 4666

Query: 1804 EALPLQMCRHPP------REKTVLVGRRAVLEVTVSRSGGH---VCWLREGAELCPGDKY 1854
              L L +   PP      ++   + G    LE  V+  G H   + W ++  E+   +KY
Sbjct: 4667 NVLDLII---PPSFTKKLKKMDSIKGSFIDLECIVA--GSHPISIQWFKDDQEISASEKY 4721

Query: 1855 EMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTR 1890
            +   H  T  L I  +   D GTY C A   + H +
Sbjct: 4722 KFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQ 4757



 Score =  212 bits (539), Expect = 3e-54
 Identities = 217/957 (22%), Positives = 410/957 (42%), Gaps = 63/957 (6%)

Query: 253   KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
             K   V  G+ A F C +  +  P +EW+ +G+ L P  + ++ R       L +   + +
Sbjct: 12203 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDK-VVPRSEGKVHTLTLRDVKLE 12260

Query: 313   DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
             D G     A++      +   L VKEP + FT+PL+D    E   AVLEC+V        
Sbjct: 12261 DAGEVQLTAKDFK----THANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 12316

Query: 373   WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
             WF+    +L  +KYE + +G VR+L+IH    +D   Y C+ +   +T  N+ V  P ++
Sbjct: 12317 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD-FKTSCNLNVVPPHVE 12375

Query: 433   --RLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGV 487
               R    L V E E A    E      + +W +DG E+    +    S G +  LV+   
Sbjct: 12376 FLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKC 12435

Query: 488   TREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPET 547
               +D  E +  +  +RT+ +L V  ++        LA +     +T+ L  +  +P  E 
Sbjct: 12436 LLDDEAEYSCEVRTARTSGMLTV--LEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEV 12493

Query: 548   PFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFH 607
               I+    +E+      +  +  +   + +    +   G+Y  R+ +    G+   V  H
Sbjct: 12494 --IWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK---VKVH 12548

Query: 608   GSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPG 666
               A     A  ++  +++++ +GE A F   +S       W  + + L+S +        
Sbjct: 12549 ELA-----AEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGD-------- 12595

Query: 667   ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSL 726
               +Y +   G +  L++     QD G  V       + +A LT+ E    ++  +D    
Sbjct: 12596 --KYDVIADGKKRVLVVKDATLQDMGTYV-VMVGAARAAAHLTVIEKLRIVVPLKD---T 12649

Query: 727   TFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF 786
                  + VV  CE++     A W+++ + + +S   ++      + L + +A + D   +
Sbjct: 12650 RVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANY 12709

Query: 787   EC-----RTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
                    R E V +   + V++  + IV+P +   +  +  + V   C+V+R +  ++W 
Sbjct: 12710 NVSLTNHRGENVKSAANLIVEEEDLRIVEPLKD--IETMEKKSVTFWCKVNRLNVTLKWT 12767

Query: 842   KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
             K+G+EV   + V    +     L +      D GE+   AG + +   + I +  +  V 
Sbjct: 12768 KNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVE 12827

Query: 902   PSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQ 961
                   V     +  V +C+L R  A V+W ++G E+ E      +K+ ++ RL++   +
Sbjct: 12828 HLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCR 12885

Query: 962   LEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVR 1021
             L+D  EY C ++D  +   + V E PV II P  ++  +      VV + EL+++   V+
Sbjct: 12886 LDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDI--LEAPGADVVFLAELNKDKVEVQ 12943

Query: 1022  WYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERI 1081
             W ++ + V + +   +  +G   RL +   +P D GE+   A D  A   + + A P+  
Sbjct: 12944 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELAAAPK-- 13001

Query: 1082  VHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLP 1141
             +  A + L +  G P  + +  +  P  ++  W+K   E E      +       +  + 
Sbjct: 13002 IKTADQDLVVDVGKPLTMVVPYDAYPK-AEAEWFK---ENEPLSTKTIDTTAEQTSFRIL 13057

Query: 1142  HAQPEDAGEY--VCETRHEA----ITFNVILAEPPVQFLAL-ETTPSPLCVAPGEPV 1191
              A+  D G Y  V + +H      I   VI    PV+ L + ET    + +A  EP+
Sbjct: 13058 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPL 13114



 Score =  202 bits (514), Expect = 3e-51
 Identities = 155/558 (27%), Positives = 257/558 (46%), Gaps = 27/558 (4%)

Query: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNG 1411
            S+E P   K+   +   TV +G DA FR  V   PD +  W +NG  +    ++      
Sbjct: 2074 SMEAP---KIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPE 2130

Query: 1412 SSRI-LTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELL-FLRRLQDVRAEEGQD 1465
             +   L +R     D+ ++ ++A    G T++ A L V+  +L+ F + LQDV A+E   
Sbjct: 2131 DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDT 2190

Query: 1466 VC-LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC-- 1522
            +   E ET        V+W + G  +    +  M  D  +H L I  +  +D   Y C  
Sbjct: 2191 MATFECETSEPFVK--VKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVL 2248

Query: 1523 -ESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
             E  + +T A+L V    +  ++ L+D+ + E  S   +  +S E + G+W    V+L  
Sbjct: 2249 VEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKS 2308

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
              K  I S   R  L +  +   D G  SF  D  +   +L ++  P+ I++G  D +V 
Sbjct: 2309 NGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVC 2368

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC- 1700
            EGD    E ++S    +  W KDG  + PS R+ +       +L +      DAG YS  
Sbjct: 2369 EGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFT 2428

Query: 1701 --AVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRP 1757
              A+G + +G V +     +V V++ L+ V+  EG  A  EC VS  + T  +W L    
Sbjct: 2429 IPALGLSTSGRVSV----YSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQ 2484

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            ++P  RV+   +G K  LV++   A D G  +   G  ++   L VE + +       R+
Sbjct: 2485 IKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIKI---IRGLRD 2541

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
             T    +  V EV +S SG  V W  +  E+ P  KY++ +HG  + L + ++  +D+G 
Sbjct: 2542 LTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGK 2601

Query: 1878 YCCQAGQDSTHTRLLVEG 1895
            Y   AG++ T  +L V G
Sbjct: 2602 YTFYAGENMTSGKLTVAG 2619



 Score =  189 bits (480), Expect = 2e-47
 Identities = 271/1226 (22%), Positives = 469/1226 (38%), Gaps = 182/1226 (14%)

Query: 15    LRFPRPVRVVSGAEAE--LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
             L+F  P++ V+  E E  +  V L      V W K  Q+L  +  +S   +G  H +   
Sbjct: 11929 LKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFK 11988

Query: 73    AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                  D       A   + EA     +TVLE                      G P F  
Sbjct: 11989 DLSIDDTSQIRVEAMGMSSEA----KLTVLE----------------------GDPYFTG 12022

Query: 133   GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
               +    +   EV+L C       P + W KDG    E+  S +  ++     DG    L
Sbjct: 12023 KLQDYTGVEKDEVILQCEISKADAP-VKWFKDGK---EIKPSKNAVIKA----DGKKRML 12074

Query: 193   ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
              L+   A   D G Y C                      S   D ++    +V PL    
Sbjct: 12075 ILK--KALKSDIGQYTCDCGT---------------DKTSGKLDIEDREIKLVRPLHSVE 12117

Query: 253   KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
                 V E + A+F   +    E +I  +W+ +               G  +L+   C+ K
Sbjct: 12118 ----VMETETARFETEIS---EDDIHANWKLK---------------GEALLQTPDCEIK 12155

Query: 313   DRG------LYVCAARNSAG------QTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVL 360
             + G      L+ C    + G         S+  L VK   +   RPL+DV       A  
Sbjct: 12156 EEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATF 12215

Query: 361   ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420
             +C++    IP  W+ + ++L P  K     EG V  L +  +K +D G      +   +T
Sbjct: 12216 DCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD-FKT 12274

Query: 421   VANVTVKGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SS 475
              AN+ VK P ++      D  V EG  AVL  E      + +W ++G E+    +    +
Sbjct: 12275 HANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVA 12334

Query: 476   SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
              G +  LV+   T ED    T    + +T+  L V      PP    L  +         
Sbjct: 12335 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV-----VPPHVEFLRPLTD------- 12382

Query: 536   LTWKPPEPAPETPFIYRLERQEVGSEDWIQC-----FSIEKAGAVE--VPGDC-VPSEGD 587
             L  +  E A     + R   +    +D  +      + I   GAV   V   C +  E +
Sbjct: 12383 LQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAE 12442

Query: 588   YRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGT 646
             Y   + T    G            L   A     L +++V + +      ++S    +  
Sbjct: 12443 YSCEVRTARTSGM--------LTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVI 12494

Query: 647   WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSC--PGVQD 704
             W+   EE+        +E G  RY I  +G +  L++     +D+G    ++C  P  + 
Sbjct: 12495 WYKGDEEI--------IETG--RYEILTEGRKRILVIQNAHLEDAG---NYNCRLPSSRT 12541

Query: 705   SAALTIQESPVHILS-PQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLV 763
                + + E     +S PQ   +L     E+    C +S+  FP  W +D + +E  +   
Sbjct: 12542 DGKVKVHELAAEFISKPQ---NLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGDKYD 12598

Query: 764   VKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSE 823
             V  DG+K  L++ +A +QD G +        A   +TV +  + IV P +   V     +
Sbjct: 12599 VIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK--EQQ 12655

Query: 824   CVMLACEVDREDAPVRWYKDGQEV-EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882
              V+  CEV+ E A  +W+++ + + + S +++L+ +  +   +  A              
Sbjct: 12656 EVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHL------------ 12703

Query: 883   DECAYFTVTITDVSSWIVYPSGKVYV--------------AAVRLERVVLTCELCRPWAE 928
             D+ A + V++T+     V  +  + V                +  + V   C++ R    
Sbjct: 12704 DDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVT 12763

Query: 929   VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPV 988
             ++WTK+GEEV     +  + +     L +      D GEY+     + +   + + E P 
Sbjct: 12764 LKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPT 12823

Query: 989   RIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVL 1048
               +   ++ T+     +  V  C+LSRE A V+WY++G E++E +    E+DG   RL++
Sbjct: 12824 EFVEHLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLII 12881

Query: 1049  PAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR-VELRCEVAP 1107
                + +D  E+ C   D  +   + V   P  I+ P    L+    APG  V    E+  
Sbjct: 12882 KDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILE----APGADVVFLAELNK 12937

Query: 1108  AGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILA 1167
                +V+W ++ + V   D  Q+ +EG    L +   +P D GEY    + +     + LA
Sbjct: 12938 DKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELA 12997

Query: 1168  EPPVQFLALETTPSPLCVAPGEPVVL 1193
               P     ++T    L V  G+P+ +
Sbjct: 12998 AAP----KIKTADQDLVVDVGKPLTM 13019



 Score =  161 bits (408), Expect = 5e-39
 Identities = 261/1322 (19%), Positives = 490/1322 (37%), Gaps = 178/1322 (13%)

Query: 7    DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
            D+  PP F R  +    +SG+   ++C V G PP  V W   G ++++  +         
Sbjct: 7677 DRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNT 7736

Query: 67   HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEG 126
              L +     +D+G Y C A N AG    +A +TV EPP+                    
Sbjct: 7737 CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPS-------------------- 7776

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
               F+  P    VL G  V  T    G P  ++ W K    L    D  + +L+   AE 
Sbjct: 7777 ---FVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSEL-VPGDRCNVSLEDSVAE- 7831

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
                   L +       SG Y C   N  G A     L +            +APA  V+
Sbjct: 7832 -------LELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI------------KAPAKFVK 7872

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
             L      + + +GK         G P   + W   G  + P  +R      +   +L++
Sbjct: 7873 RL----NDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPS-QRCNITTTEKSAILEI 7927

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
                 +D G Y C   N++G+   + Q+ + EP   F + L+ V+      A L+C++  
Sbjct: 7928 PSSTVEDAGQYNCYIENASGKDSCSAQILILEPPY-FVKQLEPVKVSVGDSASLQCQLAG 7986

Query: 367  S-RIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
            +  I  +W++ D +L P   Y+      V  L+ +++  +D G Y+C+    V  V+  T
Sbjct: 7987 TPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAST 8046

Query: 426  VKGPILKRLP----RKL-DVLEGENAVLLVETLEAGVEG---RWSRDGEEL---PVICQS 474
                  ++LP    R+L DV E     ++ +   +G E     W +DG+ L   P +  S
Sbjct: 8047 FLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTS 8106

Query: 475  SSGHMHALVLPGVTREDAGE----VTFSLGNSRTTTLLRVKCVKHSP-------PGPPIL 523
               +   L +    R  AG+     T  +G++ ++  L +   K+ P       P   ++
Sbjct: 8107 FLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV 8166

Query: 524  AEM--FKGH---KNTVLLTWKPPEPAPETPFIYRLE-----------RQEVGSEDWIQCF 567
             E   F+ H      + ++W        +   Y++            + + G      C+
Sbjct: 8167 GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCY 8226

Query: 568  SIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQV 627
            ++ + G      D   ++ + + R+   S   R    V     +       VAG + + V
Sbjct: 8227 AVNEVGK-----DSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITV 8281

Query: 628  YDGEDAVFSLDLSTIIQGTWFLNGEELK-SNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
                               W+ N  E++ ++  E   +   L  ++ + G+    +    
Sbjct: 8282 ------------------AWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCK 8323

Query: 687  KHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD-F 745
               D+G+ +   C     ++++ I+E     +  Q    +T +  E V L+C +   +  
Sbjct: 8324 VSNDAGSAL---C-----TSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPI 8375

Query: 746  PATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF----FGVTV 801
               W K G++++ S+            L L +    DSG++ C+   V+        VT+
Sbjct: 8376 RIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTI 8435

Query: 802  QDPPV-------HIVDPR-----EHVFVHAITSECVMLACEVDREDAP-VRWYK-DGQEV 847
            +D P          VD R     E   +  +         +V  +  P V+W K   +++
Sbjct: 8436 KDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQL 8495

Query: 848  EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTIT------------DV 895
             +   V +  +G   +L +  T  +D G ++CVA +E       +             + 
Sbjct: 8496 NQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEG 8555

Query: 896  SSWIVYPSGKVYVAAVRLERVVLTCELCR--------PWAEVRWTKDGEEVVESPALLLQ 947
                +     +       E  +   EL +         +A +    D   ++++  LL Q
Sbjct: 8556 DLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQ 8615

Query: 948  -KEDTVRRLVLPAVQLEDSGEYLCEIDDESASF---TVTVTEPPVRIIYPRDEVTLIAVT 1003
             +E+   RL +  ++  +  E   E   E  SF    ++ TE PV +I   +  T++   
Sbjct: 8616 SQEEETHRLEIEEIERSERDEKEFE---ELVSFIQQRLSQTE-PVTLIKDIENQTVLKDN 8671

Query: 1004 LECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
                 +  +++  +  + WYK   ++E S+   +  DG R  L +   Q +D G +    
Sbjct: 8672 DAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVC 8731

Query: 1064 GDDSAFFTVTVTAPP-ERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVE 1122
            G   A   +TV  P  ER +       D+         + C+ +    +  W+++G  ++
Sbjct: 8732 GPHIASAKLTVIEPAWERHLQ------DVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILK 8785

Query: 1123 ASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
                 +   E     LT+   + ED G+Y C+      +  + +   P+QF         
Sbjct: 8786 PQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQF---TKRIQN 8842

Query: 1183 LCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGL 1242
            + V+  +     CE+S   A V W      + E +      +G    + I    P   G+
Sbjct: 8843 IVVSEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGV 8902

Query: 1243 YT 1244
            Y+
Sbjct: 8903 YS 8904



 Score =  116 bits (290), Expect = 2e-25
 Identities = 219/1074 (20%), Positives = 389/1074 (36%), Gaps = 173/1074 (16%)

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+ DGQ++  + +  VV++ +G    +++PAT PSD GE+  VA +     ++++     
Sbjct: 1490 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPAT-PSDSGEWTVVAQNRAGRSSISVILTVE 1548

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             + +    ++V  ++   +    E  R   +VR T +    +    + L+  D +     
Sbjct: 1549 AVEHQVKPMFVEKLKNVNIK---EGSRLEMKVRATGNPNPDI----VWLKNSDIIVPHKY 1601

Query: 958  PAVQLEDS-GEYLCEID----DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
            P +++E + GE   +ID     +SA +T T      R      + T   V +E       
Sbjct: 1602 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGR------DTTRCKVNVEV------ 1649

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCR-LVLPAAQP---------EDGGEFVCD 1062
                        +  E E    L++ R   R + +  P  +P          + G+    
Sbjct: 1650 ------------EFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDK 1697

Query: 1063 AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGL 1119
                  FF   +T+   +   PA      HF         C + P G     V W  DG 
Sbjct: 1698 EKQQKPFFKKKLTSLRLKRFGPA------HF--------ECRLTPIGDPTMVVEWLHDGK 1743

Query: 1120 EVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETT 1179
             +EA++ L++  E    +L    A   D+G   C   ++  T               + T
Sbjct: 1744 PLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGT---------------DHT 1788

Query: 1180 PSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAH 1239
             + L V   + +V   +L            GR     +GL+   E  R          AH
Sbjct: 1789 SATLIVKDEKSLVEESQLP----------EGR-----KGLQRIEELERM---------AH 1824

Query: 1240 AGLYTCQSGAAPGAPSLSFTVQVAEP-PVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGG 1298
             G  T   G             V  P PVRV+  E A+ R R T             P  
Sbjct: 1825 EGALT---GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVT-----------GYPQP 1870

Query: 1299 PVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPL 1358
             V WY +G+ +    R ++   G    L +   +S D GE             V+ E P 
Sbjct: 1871 KVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGE-----------VKVTAENP- 1917

Query: 1359 LVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL 1418
               ++     L + + +D       +P               P P+  + + G  +    
Sbjct: 1918 -EGVIEHKVKLEIQQREDFRSVLRRAP--------------EPRPEFHVHEPGKLQF--- 1959

Query: 1419 RGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAA 1478
                  +   V     +T T   + ++  E +   ++ +   E         E G   A 
Sbjct: 1960 ------EVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 2013

Query: 1479 GAVRWVRGGQPLPHDSRLSMAQDGHIH----RLFIHGVILADQGTYGCESHHDRTLARLS 1534
             AV      +   ++  L   +D  +H            LA++G     +     +  LS
Sbjct: 2014 TAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKI-ELS 2072

Query: 1535 VRPRQLRVLRPLEDVTISEGGSATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIH-SDGH 1592
                  ++   ++  T+ +G  A F++  + +     EW + GV++    + + +  + +
Sbjct: 2073 PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDN 2132

Query: 1593 RHRLVLNGLGLADSG-----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT-A 1646
               LV+  +   DS       ++   ++   A  L+  +  +T  +   D+   E DT A
Sbjct: 2133 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMA 2192

Query: 1647 TFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR 1706
            TFECE S+    V W KDG  +    + R+ +      L +     SDA  YSC +    
Sbjct: 2193 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE 2252

Query: 1707 --AGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARV 1764
                  +L V    V  + EL+ +   E      EC VS     G+W      L+   + 
Sbjct: 2253 NVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKY 2312

Query: 1765 RIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGR 1824
             I     +  L + ++  ED GE  F     ++   L+++  P+ + +    +K V  G 
Sbjct: 2313 TITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQK-VCEGD 2371

Query: 1825 RAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               LEV VS       W+++G E+ P D+  +     +H L+I D+  ED G Y
Sbjct: 2372 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNY 2425



 Score =  100 bits (249), Expect = 1e-20
 Identities = 121/498 (24%), Positives = 198/498 (39%), Gaps = 82/498 (16%)

Query: 14    FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
             F+  P+ + ++ G +AE  C +  E  PV  W++  + L + ++    ADG +  L++  
Sbjct: 12554 FISKPQNLEILEGEKAEFVCSISKESFPVQ-WKRDDKTLESGDKYDVIADGKKRVLVVKD 12612

Query: 74    ALPTDAGVYVCRARNAAGEAYAAAAVTVLEP-----PASDPELQPAERPLPSPGSGEGAP 128
             A   D G YV       G A AAA +TV+E      P  D  ++  +             
Sbjct: 12613 ATLQDMGTYVV----MVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQ------------- 12655

Query: 129   VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                            EVV  C          ++  +    + ++DSS + +         
Sbjct: 12656 ---------------EVVFNCEVNTEGAKAKWFRNE----EAIFDSSKYIILQ------K 12690

Query: 189   GASLALRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
                  LRI  A L D   Y     N  G + ++ A L V           +E    +VEP
Sbjct: 12691 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIV-----------EEEDLRIVEP 12739

Query: 248   LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
             L    K     E K   F C V  +    ++W   G   +P   R+ YR      +L + 
Sbjct: 12740 L----KDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE-VPFDNRVSYRVDKYKHMLTIK 12793

Query: 308   YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS 367
              C   D G Y+     +AGQ  S  +L + E    F   L+D    E   AV  C++   
Sbjct: 12794 DCGFPDEGEYIV----TAGQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSRE 12849

Query: 368   RIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK 427
             +    W+R  + +   +KY+  ++G++ RLII   + DD+  Y C +  R ++ A + V+
Sbjct: 12850 KANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDR-KSRARLFVE 12908

Query: 428   GPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQS------SSGHM 479
                ++ +    D+LE  G + V L E  +  VE +W R+     V+ Q       S G +
Sbjct: 12909 EIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNN---MVVVQGDKHQMMSEGKI 12965

Query: 480   HALVLPGVTREDAGEVTF 497
             H L +  +   D GE  F
Sbjct: 12966 HRLQICDIKPRDQGEYRF 12983



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 191/1020 (18%), Positives = 346/1020 (33%), Gaps = 168/1020 (16%)

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVT 891
             A V+WY +G E++ES  +   N      L +      D G ++ V     G+   Y T+ 
Sbjct: 32403 AEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLD 32462

Query: 892   ITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDT 951
             +T    +  Y S +      R     LT      +A   + K  E    S    ++ + T
Sbjct: 32463 VTG-GDYTTYASQRRDEEVPRSVFPELT--RTEAYAVSSFKKTSEMEASSSVREVKSQMT 32519

Query: 952   VRRLVLPAVQLEDSGEYLC------EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLE 1005
               R  L + +   S E          ++++S +  +  T     +  PR   ++     E
Sbjct: 32520 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR---SMTVYEGE 32576

Query: 1006  CVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--- 1061
                  C+   E  P V W + G  +  S    +     +    + + Q  D G +     
Sbjct: 32577 SARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVE 32636

Query: 1062  -DAGDDSAFFTVT----------VTAPPE------RIVHPAA------------------ 1086
                G   A FT+T          VT+PP       R+  P A                  
Sbjct: 32637 NSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAV 32696

Query: 1087  -----------RSLDLHFGAPGRV-------------ELRCEVAPA---GSQVRWYKDGL 1119
                        +   L   AP ++             +L C V  +     +V WYKDG 
Sbjct: 32697 SPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGK 32756

Query: 1120  EVEASDALQL--GAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLAL- 1176
             +++ +   Q    A+G T  L + +    D GEYVCE   E  T    L      F ++ 
Sbjct: 32757 KLKENGHFQFHYSADG-TYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH 32815

Query: 1177  -----------------ETT---------PSPLCVAP-----------GEPVVLSCELSR 1199
                              E+T         P P+   P               V    +  
Sbjct: 32816 EKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKA 32875

Query: 1200  AGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSL 1256
              G P    +W+ +G+ + +G   +L  +     L I     + +GLYTC    + G+ S 
Sbjct: 32876 TGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 32935

Query: 1257  SFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQ 1316
             S  + +           + Q     TP     +   +S         K  E   SQ ++ 
Sbjct: 32936 SCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEA-KSQEKLA 32994

Query: 1317  LEQAGARQVLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGD 1375
             L++  ++ ++  +  +S     E      + ++    S E     ++ +  T ++++EG 
Sbjct: 32995 LKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQ 33054

Query: 1376  DATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGS 1435
                 +  ++    DV W+ NG  +T   +     +GS + LT++     D G +T     
Sbjct: 33055 RLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTC---I 33110

Query: 1436  TATSARLHVRETELLFLRRLQDVRA----------EEGQDVCLEVETGRVGAAGAVRWVR 1485
             + T   +   + +L   + L D  A           EGQ+V    E      +  + W +
Sbjct: 33111 SKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISG-EPSPEIEWFK 33169

Query: 1486  GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDR----TLARLSVRPRQLR 1541
                P+   S +S+++  +++ L I    ++D G Y  ++ + R      A L V P    
Sbjct: 33170 NNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP---L 33226

Query: 1542  VLRPLEDVTISEGGSATFQLELSQEGV--TGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
             V  P  +V +   G  + Q   S + V  +          +        ++     +   
Sbjct: 33227 VEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQ 33286

Query: 1600  GLGLADSGCVSFTADSLRCAARLI-------------VREVPVTIVRGPHDLEVTEGDTA 1646
              +       V  ++ S    + +              +R +P  I   P D+ + EG   
Sbjct: 33287 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 33346

Query: 1647  TFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVG 1703
             T  C  + +   +VTW   G  +    + R     T  L  L +      D G Y+ ++G
Sbjct: 33347 TVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLG 33406



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 113/494 (22%), Positives = 184/494 (37%), Gaps = 82/494 (16%)

Query: 15    LRFPRPVRVVSGAEAELKCVV--LGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
             L+F  P+   +  E E    V  L      VVW K   +L  S  +   ++G  H L + 
Sbjct: 11574 LKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMK 11633

Query: 73    AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                  D    + + +    E  + A + VLE                        P F  
Sbjct: 11634 EVTLDD----ISQIKAQVKELSSTAQLKVLEAD----------------------PYFTV 11667

Query: 133   GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
                 +  +   E+ L C      +  + W KDG   +E+  S  ++++        G   
Sbjct: 11668 KLHDKTAVEKDEITLKCEVS--KDVPVKWFKDG---EEIVPSPKYSIK------ADGLRR 11716

Query: 193   ALRILAARLPDSGVYVCHARNAHGHAQA---GALLQVHQPPESPPADPDEAPAPVVEPLK 249
              L+I  A L D G YVC        A       L++V            E P   VE   
Sbjct: 11717 ILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKV------------EKPLYGVE--- 11761

Query: 250   CAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL--PDRRRLMYRDRDGGFVLKVL 307
                   +V E  H +     + +P+   +W  +G+PL   PD   +     DG   + +L
Sbjct: 11762 -----VFVGETAHFEIE---LSEPDVHGQWKLKGQPLTASPDCEII----EDGKKHILIL 11809

Query: 308   Y-CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
             + CQ    G     A N+     SA  L VKE  L F  PL DV+  E   A  EC+V  
Sbjct: 11810 HNCQLGMTGEVSFQAANAK----SAANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSR 11865

Query: 367   SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
                   W +  Q +    ++E I++GT   ++I     +D+  Y+ E   +  T   + +
Sbjct: 11866 EPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDK-HTSGKLII 11924

Query: 427   KGPILKRLPRKLDVL--EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHA 481
             +G  LK L    DV   E E+AV  VE     +  +W ++ + L     +     G  H+
Sbjct: 11925 EGIRLKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 11984

Query: 482   LVLPGVTREDAGEV 495
             +    ++ +D  ++
Sbjct: 11985 ITFKDLSIDDTSQI 11998



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 63/239 (26%), Positives = 93/239 (38%), Gaps = 32/239 (13%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            +PP  +   + V V+ G    L+C + G P P V W +   Q+ +S             L
Sbjct: 941  TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARL 1000

Query: 70   LLTAALPTDAGVYVCRARNAAG-------------EAYAAAAVTVLEPPASDPELQPAER 116
            ++  A   D+G + C A N AG             E +      V E   ++ +     R
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1060

Query: 117  PL---------PSPGSGE-GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGM 166
             +            G GE  AP F+T P  Q ++ G  VV  C+ GG P+P +YW+K G+
Sbjct: 1061 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1120

Query: 167  ALDEVWD-SSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL 224
             L   +     +  Q G  +        L I      D+G Y    RN HG   A A L
Sbjct: 1121 PLTTGYRYKVSYNKQTGECK--------LVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 92/387 (23%), Positives = 137/387 (35%), Gaps = 78/387 (20%)

Query: 18    PRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPT 77
             PR + V  G  A   C   GEP P V W + GQ L+ S R        +    +++   +
Sbjct: 32567 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQAS 32626

Query: 78    DAGVYVCRARNAAGEAYAAAAVTVL------------------EPPASDPELQPAERPLP 119
             D G Y     N+ G+  A   +T+                   EP    PE   + + + 
Sbjct: 32627 DEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 32686

Query: 120   SPGSG------------------EGAPVFLTGPRSQWVLRGAE---VVLTC--RAGGLPE 156
             SP                     +  PV      +Q++   A      LTC   +  L  
Sbjct: 32687 SPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRA 32746

Query: 157   PTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHG 216
               + W KDG  L E   + HF      + DG   +  L+I      D G YVC      G
Sbjct: 32747 KEVTWYKDGKKLKE---NGHFQFH--YSADG---TYELKINNLTESDQGEYVCEISGEGG 32798

Query: 217   HAQAG------ALLQVHQP--------------PESPPADPDEAPAPVVEPLKCAP---- 252
              ++        A   +H+                ES      E  AP  EP+   P    
Sbjct: 32799 TSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAP--EPISSKPVIVT 32856

Query: 253   --KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
               +   V+    AKF     G+P P   W  +G+ +    +  +  D+ GGF L++    
Sbjct: 32857 GLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDK-GGFFLEIHKTD 32915

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHVK 337
               D GLY C  +NSAG   S+ +L +K
Sbjct: 32916 TSDSGLYTCTVKNSAGSVSSSCKLTIK 32942



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 78/398 (19%)

Query: 22   RVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGLLLTAALPTDA 79
            R++ G      C + G P P + W K G+++   ER  + F  DG    L +   LP D 
Sbjct: 1301 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVLPEDE 1359

Query: 80   GVYVCRARNAAGEAYAAAAVTV-----LEPPASDPELQPAER------------PL---- 118
            G+Y   A N  G A  +  + V     L  P   P L+P  R            P+    
Sbjct: 1360 GIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSP 1419

Query: 119  -----------------PSPG-----SGEG------APVFLTGPRSQWVLRGAEVVLTCR 150
                              SPG     + E        PVF+  P S   L G       +
Sbjct: 1420 ARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLK 1479

Query: 151  AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCH 210
              G P P  +W  DG  +  V D +H  +     EDG   + +L I+ A   DSG +   
Sbjct: 1480 VVGRPMPETFWFHDGQQI--VNDYTHKVV---IKEDG---TQSLIIVPATPSDSGEWTVV 1531

Query: 211  ARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVM 270
            A+N  G +    +L V        A   +     VE L    K   + EG   + +    
Sbjct: 1532 AQNRAGRSSISVILTVE-------AVEHQVKPMFVEKL----KNVNIKEGSRLEMKVRAT 1580

Query: 271  GKPEPEIEWHWEGRPLLPDR-RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTL 329
            G P P+I W      ++P +  ++      G   LK+    ++D   Y   A N AG+  
Sbjct: 1581 GNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDT 1640

Query: 330  SAVQLHVK------EPRLRFTRPLQDVEGREHGIAVLE 361
            +  +++V+      EP  +   P      +E     LE
Sbjct: 1641 TRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELE 1678



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 123/502 (24%), Positives = 190/502 (37%), Gaps = 74/502 (14%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
             G+ A  +C+V      +  W K G  +  S +  F ADG +  L +     +DAG Y C 
Sbjct: 11133 GSSAIFECLV-SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 11191

Query: 86    ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145
              R    E  + A + V E P                          T      V++G  +
Sbjct: 11192 LRLGNKEKTSTAKLVVEELPVR---------------------FVKTLEEEVTVVKGQPL 11230

Query: 146   VLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP-GASLALRILAARLPDS 204
              L+C      E  + W KDG  + E         +PGR   G  G   AL I  A   D+
Sbjct: 11231 YLSCELN--KERDVVWRKDGKIVVE---------KPGRIVPGVIGLMRALTINDADDTDA 11279

Query: 205   GVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAK 264
             G Y     NA+ + +  + ++V +               +V+P+    +   V     A 
Sbjct: 11280 GTYTVTVENAN-NLECSSCVKVVEVIRD----------WLVKPI----RDQHVKPKGTAI 11324

Query: 265   FRCYVMGKPEPEIEWH--WEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
             F C +  K  P I+W   ++  P  P+ +  + RD      LK+     +D   Y   A 
Sbjct: 11325 FACDI-AKDTPNIKWFKGYDEIPAEPNDKTEILRD-GNHLYLKIKNAMPEDIAEY---AV 11379

Query: 323   NSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLP 382
                G+   A +L + E  +   +P++DV   E   A  + ++  + IP  W  + + L P
Sbjct: 11380 EIEGKRYPA-KLTLGEREVELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRP 11438

Query: 383   CRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLE 442
                 E   EG  R L +H++K D  G  L +    + T A +TVK   L       DV  
Sbjct: 11439 SPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAI-TTAILTVKEIELDFAVPLKDVTV 11497

Query: 443   GENAVLLVE---TLEAGVEGRWSRDGEELPVICQSS-------SGHMHALVLPGVTREDA 492
              E      E   T EA V   WS+     P I +SS        G  H LV+     +D 
Sbjct: 11498 PERRQARFECVLTREANV--IWSKG----PDIIKSSDKFDIIADGKKHILVINDSQFDDE 11551

Query: 493   GEVTFSLGNSRTTTLLRVKCVK 514
             G  T  +   +T+  L V  ++
Sbjct: 11552 GVYTAEVEGKKTSARLFVTGIR 11573



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 118/552 (21%), Positives = 194/552 (35%), Gaps = 105/552 (19%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGL 69
            P F+  P   ++V G      C V G P P V W+K G  L    R  +S+     E  L
Sbjct: 1082 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1141

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL---------PS 120
            +++     DAG Y    RN  GE   +A+ ++LE    +  ++  +  L           
Sbjct: 1142 VISMTFADDAGEYTIVVRNKHGET--SASASLLEEADYELLMKSQQEMLYQTQVTAFVQE 1199

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
            P  GE AP F+     +   +   ++    A        Y E      D+ +  S F   
Sbjct: 1200 PKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE------DQEFHISSF--- 1250

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240
                E+     +  RI+   L +                    L      E    D  E+
Sbjct: 1251 ----EERLIKEIEYRIIKTTLEE--------------------LLEEDGEEKMAVDISES 1286

Query: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
             A V        K + + EG    F C + G P P+I W+ +G+ +    R  M   +DG
Sbjct: 1287 EA-VESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1345

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK--------------EPRLRFTRP 346
               L++     +D G+Y   A N  G  + + +L+V+              EP  R  R 
Sbjct: 1346 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRI-RS 1404

Query: 347  LQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADD 406
            L         I +   ++  +R+  A      R+ P R+ E+ +E  + RL         
Sbjct: 1405 LSPRSVSRSPIRMSPARMSPARMSPARM-SPARMSPGRRLEETDESQLERLY-------- 1455

Query: 407  DGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGV-EGRWSRDG 465
                                  P+    P     LEG+ A   ++ +   + E  W  DG
Sbjct: 1456 ---------------------KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDG 1494

Query: 466  EEL-----PVICQSSSGHMHALVLPGVTREDAGEVTF----SLGNSRTTTLLRVKCVKHS 516
            +++       +     G    +++P  T  D+GE T       G S  + +L V+ V+H 
Sbjct: 1495 QQIVNDYTHKVVIKEDGTQSLIIVP-ATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQ 1553

Query: 517  PPGPPILAEMFK 528
                P+  E  K
Sbjct: 1554 V--KPMFVEKLK 1563



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 91/395 (23%), Positives = 142/395 (35%), Gaps = 87/395 (22%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA--EHGL 69
            P F+   + V +  G+  E+K    G P P +VW K    +   +      +G   E  L
Sbjct: 1556 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1615

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP-------- 121
             + + +  D+  Y   A N AG       V V E   ++PE    ER L  P        
Sbjct: 1616 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNV-EVEFAEPE---PERKLIIPRGTYRAKE 1671

Query: 122  -GSGEGAPVFLTGPRSQW------------------------VLRGAEVVLTCRAGGLPE 156
              + E  P+ L   + QW                        + R       CR   + +
Sbjct: 1672 IAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGD 1731

Query: 157  PTLY--WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
            PT+   W  DG  L+        A +     +    SL   +  +R  DSG+  C A N 
Sbjct: 1732 PTMVVEWLHDGKPLEA-------ANRLRMINEFGYCSLDYGVAYSR--DSGIITCRATNK 1782

Query: 215  HGHAQAGA---------LLQVHQPPESPPA---------------------DPDEAPAPV 244
            +G     A         L++  Q PE                         D  E   P 
Sbjct: 1783 YGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKP- 1841

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFV 303
               +   P+   V EG+ A+FRC V G P+P++ W+  G+ +   +R R+ Y   DG   
Sbjct: 1842 --DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHY 1896

Query: 304  LKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
            L ++ C++ D G     A N  G     V+L +++
Sbjct: 1897 LDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1931



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 113/549 (20%), Positives = 201/549 (36%), Gaps = 46/549 (8%)

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT---------V 981
             WTKDG+ + +     L ++     L +      DSG Y C + + + S +         +
Sbjct: 32885 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAI 32944

Query: 982   TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
               TE          E+T      +  V+  E+S++       K   E +  E L L+ + 
Sbjct: 32945 KDTEAQKVSTQKTSEIT----PQKKAVVQEEISQKALRSEEIKMS-EAKSQEKLALKEEA 32999

Query: 1042  PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAAR--SLDLHFGAPGRV 1099
              +   VL + + +       +        T T  A  E   H   +  S  +      R+
Sbjct: 33000 SK---VLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 33056

Query: 1100  ELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR-HE 1158
              L+  +A A + V+W  +G+E+  S+  + G  G  +TLT+  A   D G   C ++  E
Sbjct: 33057 VLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKE 33115

Query: 1159  AIT---FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQ 1214
              I    +++ L++      A  + P    +  G+ V+ +CE+S   +P + W  N  P+ 
Sbjct: 33116 GIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS 33175

Query: 1215  EGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS----GAAPGAPSLSFTVQVAEPPVRVV 1270
                 + +        L I+ A  + +G YT ++    G      SL     V EP   VV
Sbjct: 33176 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 33235

Query: 1271  APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQ------GRVQLEQAGARQ 1324
                +  T   S  G      V +S       +       AS         +  +   + Q
Sbjct: 33236 LRTSGDT---SLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQ 33292

Query: 1325  VLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE- 1382
                V+ + S   G   +      +   L +    +  K+ +  + +++ EG   T  C  
Sbjct: 33293 ESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAF 33352

Query: 1383  VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL--RGCQLGDAGTVTL----RAGST 1436
                P  +VTW   G  +    Q       +  + TL     Q  D G  TL      GS 
Sbjct: 33353 TGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSD 33412

Query: 1437  ATSARLHVR 1445
             + +  +H+R
Sbjct: 33413 SATVNIHIR 33421



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 60/208 (28%), Positives = 78/208 (37%), Gaps = 29/208 (13%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASE---RLSFPADGAEHGLLLTAALPTDAGVY 82
             G        +   P P V W K GQ++   +   + +F +D   + L + +    D   Y
Sbjct: 31704 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 31763

Query: 83    VCRARNAAGEAYAAAAVTV-LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLR 141
                ARN  GE    A +TV L PP +D  L+P  + L            L     Q    
Sbjct: 31764 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRL------------LANAECQ---E 31808

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS-LALRILAAR 200
             G  V    R  G+P PTL WEKDG  L         +L P       G    AL I    
Sbjct: 31809 GQSVCFEIRVSGIPPPTLKWEKDGQPL---------SLGPNIEIIHEGLDYYALHIRDTL 31859

Query: 201   LPDSGVYVCHARNAHGHAQAGALLQVHQ 228
               D+G Y   A N  G     A LQV +
Sbjct: 31860 PEDTGYYRVTATNTAGSTSCQAHLQVER 31887



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 57/217 (26%), Positives = 83/217 (38%), Gaps = 30/217 (13%)

Query: 17    FPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALP 76
             F   + +  G    LK  + G     V W   G +L  SE   +   G++  L +  A  
Sbjct: 33044 FSTQMSINEGQRLVLKANIAGATD--VKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASH 33101

Query: 77    TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRS 136
              D G+  C ++   G       +T L    SD                  AP F++ PRS
Sbjct: 33102 RDEGILTCISKTKEGIVKCQYDLT-LSKELSD------------------APAFISQPRS 33142

Query: 137   QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRI 196
             Q +  G  V+ TC   G P P + W K+ + +     SS+ ++   R         +L I
Sbjct: 33143 QNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS---ISSNVSISRSR------NVYSLEI 33193

Query: 197   LAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               A + DSG Y   A+N  G   A A L V    E P
Sbjct: 33194 RNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEP 33230



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 81/369 (21%), Positives = 132/369 (35%), Gaps = 67/369 (18%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLA--ASERLSFPADGAEHGL 69
            P F+  P   + + G  A     V+G P P   W   GQQ+    + ++    DG +  L
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-SL 1515

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
            ++  A P+D+G +   A+N AG +  +  +TV          +  E  +         P+
Sbjct: 1516 IIVPATPSDSGEWTVVAQNRAGRSSISVILTV----------EAVEHQV--------KPM 1557

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
            F+   ++  +  G+ + +  RA G P P + W K+    D +    +    P    +G  
Sbjct: 1558 FVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS---DIIVPHKY----PKIRIEGTK 1610

Query: 190  ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPAD-----------PD 238
               AL+I +    DS  Y   A N  G       + V      P  +             
Sbjct: 1611 GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAK 1670

Query: 239  EAPAPVVEPLKCAPKTFWVNEG---------------------------KHAKFRCYVMG 271
            E  AP +EPL          EG                            H + R   +G
Sbjct: 1671 EIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIG 1730

Query: 272  KPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
             P   +EW  +G+P L    RL   +  G   L      ++D G+  C A N  G   ++
Sbjct: 1731 DPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTS 1789

Query: 332  VQLHVKEPR 340
              L VK+ +
Sbjct: 1790 ATLIVKDEK 1798



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 193/1091 (17%), Positives = 363/1091 (33%), Gaps = 146/1091 (13%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G++ +F   V  KP  E++W+  G   L +  ++ Y +  G   L++L C   D G Y  
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVE-LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRA 32446

Query: 320   AARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECK---VPNSRIPTAWFRE 376
                N  G+      L              DV G ++     + +   VP S  P     E
Sbjct: 32447 VCTNYKGEASDYATL--------------DVTGGDYTTYASQRRDEEVPRSVFPELTRTE 32492

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGI--YLCEMRGRVRTVA------------ 422
                +   +K  ++E  +  R +  ++    + +  Y       +++ A            
Sbjct: 32493 AYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTT 32552

Query: 423   ---NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ---SS 475
                  T+   IL + PR + V EGE+A    +T    V    W R G+ L    +   ++
Sbjct: 32553 RKIKTTLAARILTK-PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTT 32611

Query: 476   SGHMHALVLPGVTREDAGEVTFSLGNSR-------TTTLLRVKCVKHSPPGPPIL----- 523
             + +     +  V   D G  +  + NS        T T+ + +  + +   PP +     
Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 32671

Query: 524   ----AEMFKGHKNTVLLTWKPPEPA----------PETPFIYRLERQEVGSEDWIQCFSI 569
                  E  K  K       K PEP+            TP   +++   V +   I  F  
Sbjct: 32672 RVKSPEAVKSPKRV-----KSPEPSHPKAVSPTETKPTP-TEKVQHLPVSAPPKITQFLK 32725

Query: 570   EKAGAVEVPGDCVPSEGDYRFRICTVSGHGR----SPHVVFHGSAHLVPTARLVAGLEDV 625
              +A        CV      R +  T    G+    + H  FH SA               
Sbjct: 32726 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSA--------------- 32770

Query: 626   QVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI--L 683
                   D  + L ++ + +      GE +     EG      L++  +     H  +  +
Sbjct: 32771 ------DGTYELKINNLTESD---QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 32821

Query: 684   HAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV 743
                K  D            +  A   I   PV +   QD    + + ++  V      R 
Sbjct: 32822 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 32881

Query: 744   DFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
                A W KDG+ + +     +  D     L + +    DSG + C  +  +     + + 
Sbjct: 32882 --TAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 32939

Query: 804   PPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQ----EVEESDFVVLENEG 859
                 I D          TSE       V +E+   +  +  +    E +  + + L+ E 
Sbjct: 32940 TIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEA 32999

Query: 860   PHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLT 919
                 +     + +     + +  +E    +    +V +     +    ++    +R+VL 
Sbjct: 33000 SKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLK 33059

Query: 920   CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESA-- 977
               +     +V+W  +G E+  S         + + L +      D G   C    +    
Sbjct: 33060 ANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIV 33118

Query: 978   ------SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVE 1030
                   + +  +++ P  I  PR +        + V+  CE+S E +P + W+K+ L + 
Sbjct: 33119 KCQYDLTLSKELSDAPAFISQPRSQNINEG---QNVLFTCEISGEPSPEIEWFKNNLPIS 33175

Query: 1031  ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLD 1090
              S  + + R      L +  A   D G++   A +     + T +     +V   +R + 
Sbjct: 33176 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 33235

Query: 1091  LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE 1150
             L     G   L+   +    Q+   K      +  +    +    +  ++         E
Sbjct: 33236 LR--TSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQE 33293

Query: 1151  YVCE------------TRHEAITFNVILAE----PPVQFLALETTPSPLCVAPGEPVVLS 1194
                E            T+ E+ T  ++ A     PP     +E  PS + +  G+ + ++
Sbjct: 33294 SFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPP----KIEALPSDISIDEGKVLTVA 33349

Query: 1195  CELSRAGAP-VVWSHNGRPVQEGEGLELHAEG--PRRVLCIQAAGPAHAGLYTCQSGAAP 1251
             C  +    P V WS  GR +   E    H E       L I        GLYT   G   
Sbjct: 33350 CAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEF 33409

Query: 1252  GAPSLSFTVQV 1262
             G+ S +  + +
Sbjct: 33410 GSDSATVNIHI 33420



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 60/241 (24%), Positives = 80/241 (33%), Gaps = 46/241 (19%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P  ++G ++  V+ G  V L C   G P PT+ W ++   ++   D      Q G A   
Sbjct: 943  PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIAR-- 999

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE---------------- 231
                  L I  A   DSG + C A N  G       L V    E                
Sbjct: 1000 ------LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1053

Query: 232  -----------------SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                                A P E  AP         K     EG    F C V G P+
Sbjct: 1054 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV---EGGSVVFGCQVGGNPK 1110

Query: 275  PEIEWHWEGRPLLPD-RRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQ 333
            P + W   G PL    R ++ Y  + G   L +    A D G Y    RN  G+T ++  
Sbjct: 1111 PHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASAS 1170

Query: 334  L 334
            L
Sbjct: 1171 L 1171



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 69/279 (24%), Positives = 113/279 (40%), Gaps = 54/279 (19%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE----RLSFPADGAEH 67
           P F +  + V V+ G+ A  +  + G P P V W + GQ ++ S     ++SF    A+ 
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK- 64

Query: 68  GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            L + A    ++G Y  +A N +G+A + A + V    A                     
Sbjct: 65  -LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA--------------------P 103

Query: 128 PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
           P F+   +S  V +G++V L  R  G+P P + + +DG    E+  S  F +        
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGA---EIQSSLDFQISQ------ 154

Query: 188 PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
            G   +L I  A   DSG Y  +A N+ G A + A L V    E P            + 
Sbjct: 155 EGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVP-----------AKK 203

Query: 248 LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            K    T  ++E +  +         E +IE H++ R +
Sbjct: 204 TKTIVSTAQISESRQTRI--------EKKIEAHFDARSI 234



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 63/225 (28%), Positives = 91/225 (40%), Gaps = 30/225 (13%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD---GAEHG 68
             P F    R + V   + A L C V G P P+V W + G+++ A + L +      G  H 
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIA-DGLKYRIQEFKGGYHQ 30986

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
             L++ +    DA VY  RA N  G     A++ V           PA+  LP    G GA 
Sbjct: 30987 LIIASVTDDDATVYQVRATNQGGSVSGTASLEV---------EVPAKIHLPKTLEGMGA- 31036

Query: 129   VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                        LRG  V +     G P+P + W+K    +D   ++ H+ +   R+    
Sbjct: 31037 --------VHALRGEVVSIKIPFSGKPDPVITWQKGQDLID---NNGHYQVIVTRS---- 31081

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               SL       R  D+G YV  A+N  G  Q    L V   P+ P
Sbjct: 31082 FTSLVFPNGVER-KDAGFYVVCAKNRFGIDQKTVELDVADVPDPP 31125



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 46/178 (25%), Positives = 74/178 (41%), Gaps = 5/178 (2%)

Query: 1719 VAVLSELRSVSAREGDGATFECTV--SEVETTGRWELGGRPLRPGARVRIRQEGKKHILV 1776
            V ++ ++ + +  + + A FE  +  +  E    W  G   L P  +  I  +G +H L 
Sbjct: 8656 VTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLR 8715

Query: 1777 LSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSG 1836
            +   + +D G  R   GP  + A L V     +  RH  ++ T+  G+   +    S   
Sbjct: 8716 VKNCQLKDQGNYRLVCGPHIASAKLTVIEPAWE--RHL-QDVTLKEGQTCTMTCQFSVPN 8772

Query: 1837 GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
                W R G  L P  +++       H L I DVR EDQG Y C+     T   L +E
Sbjct: 8773 VKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIE 8830



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 120/558 (21%), Positives = 202/558 (36%), Gaps = 73/558 (13%)

Query: 492   AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
             A E    +G     ++    C    PPGPP   ++    +++V L W  P      P   
Sbjct: 24977 AAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKG 25036

Query: 551   YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSA 610
             Y +E +E  +++W  C         +     +    +Y FRIC ++  G        GS 
Sbjct: 25037 YVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSV 25096

Query: 611   HLV-----PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEP 665
                     P   L A L  V V     A  +L L   I+G       E+K  + EG +  
Sbjct: 25097 VAQERIEPPEIELDADLRKVVVLR---ASATLRLFVTIKGR---PEPEVKWEKAEGILTD 25150

Query: 666   GALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVS 725
                R +IE       L++  V   DSG    ++     +S + T   +   + SP   V+
Sbjct: 25151 ---RAQIEVTSSFTMLVIDNVTRFDSGR---YNLTLENNSGSKTAFVNVRVLDSPSAPVN 25204

Query: 726   LTF--TTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAKVQD 782
             LT      + V L+ E   +D        G K+  +  +V K +  RK    +     + 
Sbjct: 25205 LTIREVKKDSVTLSWEPPLID-------GGAKI--TNYIVEKRETTRKAYATITNNCTKT 25255

Query: 783   SGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDREDAP 837
             +   E   EG S +F V   +      P    +P + V    +    V L  +V R  A 
Sbjct: 25256 TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVK-VSEPPLPPGRVTLV-DVTRNTAT 25313

Query: 838   VRWYK---DGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
             ++W K   DG        V ++ +G  +       +  +       AG+E  +    + +
Sbjct: 25314 IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNE 25373

Query: 895   -------------------VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
                                +   +  P     V A    ++ +  +  RP A V W KDG
Sbjct: 25374 KGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFK-GRPQATVNWRKDG 25432

Query: 936   EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT---------EP 986
             + + E+  + +    TV  L +     ED G Y   + + + S TV +T           
Sbjct: 25433 QTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPG 25492

Query: 987   PVRIIYPRDEVTLIAVTL 1004
             P+RI    DEV+  ++T+
Sbjct: 25493 PIRI----DEVSCDSITI 25506



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 75/318 (23%), Positives = 117/318 (36%), Gaps = 24/318 (7%)

Query: 43    VVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV- 101
             V W  G +QL  SE+     +     L +      D G Y C+  N  GE  + A + V 
Sbjct: 31600 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 31659

Query: 102   ----LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
                 +        ++  +R   +    E  P F     ++    G  V         PEP
Sbjct: 31660 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 31719

Query: 158   TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
              + W K G  +    +   +  +  +          L I +    D   Y   ARN +G 
Sbjct: 31720 HVTWYKSGQKIKPGDNDKKYTFESDKG------LYQLTINSVTTDDDAEYTVVARNKYGE 31773

Query: 218   AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
                 A L V   P  PP D    P       K         EG+   F   V G P P +
Sbjct: 31774 DSCKAKLTVTLHP--PPTDSTLRPM-----FKRLLANAECQEGQSVCFEIRVSGIPPPTL 31826

Query: 278   EWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             +W  +G+PL L     +++   D  + L +     +D G Y   A N+AG T  + Q H+
Sbjct: 31827 KWEKDGQPLSLGPNIEIIHEGLD-YYALHIRDTLPEDTGYYRVTATNTAGST--SCQAHL 31883

Query: 337   KEPRLRFTRPLQDVEGRE 354
             +  RLR+ +  Q+ + +E
Sbjct: 31884 QVERLRYKK--QEFKSKE 31899



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 144/696 (20%), Positives = 245/696 (35%), Gaps = 128/696 (18%)

Query: 252   PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
             P++  V EG+ A+F C   G+P P + W  +G+ L    R  +   +      ++   QA
Sbjct: 32567 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKS-TFEISSVQA 32625

Query: 312   KDRGLYVCAARNSAGQTLSAVQLHVKEPRL---------RFTRPLQDVEGREHGIAVLEC 362
              D G Y     NS G+  +   L +++ R+         R   P   V+  E   +    
Sbjct: 32626 SDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRV 32685

Query: 363   KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
             K P    P A    + +  P  K + +      + I   LKA+             + +A
Sbjct: 32686 KSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPK-ITQFLKAEAS-----------KEIA 32733

Query: 423   NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHM--- 479
              +T                  E++VL  +      E  W +DG++L       +GH    
Sbjct: 32734 KLT---------------CVVESSVLRAK------EVTWYKDGKKL-----KENGHFQFH 32767

Query: 480   ------HALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKG 529
                   + L +  +T  D GE    +    G S+T      +  K        ++E  K 
Sbjct: 32768 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKS 32827

Query: 530   HKNTVLLTW------KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE------V 577
              + T   T       K PEP    P I    +    S D +  F+++  G          
Sbjct: 32828 DQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK 32887

Query: 578   PGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSL 637
              G  +   G Y+                F    H   T+   +GL    V +   +V S 
Sbjct: 32888 DGKAITQGGKYKL---------SEDKGGFFLEIHKTDTSD--SGLYTCTVKNSAGSVSSS 32936

Query: 638   DLSTI--IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH---------AV 686
                TI  I+ T        K++E   Q +   ++  I QK L+   I           A+
Sbjct: 32937 CKLTIKAIKDTEAQKVSTQKTSEITPQ-KKAVVQEEISQKALRSEEIKMSEAKSQEKLAL 32995

Query: 687   KHQDSGALVGFSCPGVQDSAALTIQESPVH-------ILSPQDR---------VSLTFTT 730
             K + S  L+      V+ SAA ++++S VH         S + R           ++   
Sbjct: 32996 KEEASKVLIS---EEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINE 33052

Query: 731   SERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC-- 788
              +R+VL   ++       W  +G ++  SE     + G    L + +A  +D G   C  
Sbjct: 33053 GQRLVLKANIAGAT-DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCIS 33111

Query: 789   -RTEG-VSAFFGVT----VQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWY 841
                EG V   + +T    + D P  I  PR     +    + V+  CE+  E +P + W+
Sbjct: 33112 KTKEGIVKCQYDLTLSKELSDAPAFISQPRSQ---NINEGQNVLFTCEISGEPSPEIEWF 33168

Query: 842   KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEF 877
             K+   +  S  V +        L +     SD G++
Sbjct: 33169 KNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 33204



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/115 (27%), Positives = 50/115 (43%)

Query: 9     GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
             G  P   +  + V    G  A+L C ++G P P + W + G++L  S +    +DG  H 
Sbjct: 30530 GEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT 30589

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGS 123
             L +      D GVY C A N  GE   ++ + +   P   P     E+   + GS
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGS 30644



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 81/379 (21%), Positives = 133/379 (35%), Gaps = 82/379 (21%)

Query: 131   LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD--------------------- 169
             LT PRS  V  G     +C   G P PT+ W + G  L                      
Sbjct: 32564 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 32623

Query: 170   EVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGV-YVCHARNAHGHAQAGALLQVHQ 228
             +  D  ++++    +E    A   L I  AR+ +  V      ++     ++   ++  +
Sbjct: 32624 QASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPK 32683

Query: 229   PPESP-PADP------DEAPAPVVE----PLKCAPK--TFWVNEGKH--AKFRCYVMGK- 272
               +SP P+ P      +  P P  +    P+   PK   F   E     AK  C V    
Sbjct: 32684 RVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSV 32743

Query: 273   -PEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
                 E+ W+ +G+ L  +     +   DG + LK+      D+G YVC      G + + 
Sbjct: 32744 LRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTN 32803

Query: 332   VQ--------LHVKEPRL----------------RFTRP---------------LQDVEG 352
             +Q        +H K  ++                R T P               LQD   
Sbjct: 32804 LQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTV 32863

Query: 353   REHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL 411
                 +A    K      PTA W ++ + +    KY+  E+     L IH+    D G+Y 
Sbjct: 32864 SSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYT 32923

Query: 412   CEMR---GRVRTVANVTVK 427
             C ++   G V +   +T+K
Sbjct: 32924 CTVKNSAGSVSSSCKLTIK 32942



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 44/164 (26%), Positives = 77/164 (46%), Gaps = 10/164 (6%)

Query: 1366 LTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPG--PQVEMAQNGSSRILTLRGCQ 1422
            L  + V EG  ATF   +S  P  +V+W R+G V++    P V+++ +     LT+    
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVT 71

Query: 1423 LGDAGTVTLRA----GSTATSARLHVRETELL--FLRRLQDVRAEEGQDVCLEVETGRVG 1476
              ++G  +L+A    G   ++A L V+       F++RLQ +   +G  V L+V    + 
Sbjct: 72   KANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIP 131

Query: 1477 AAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
                V++ R G  +       ++Q+G ++ L I      D GTY
Sbjct: 132  TP-VVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTY 174



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 12/141 (8%)

Query: 1020 VRWYKDGLEVEESE--ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV--- 1074
            V W++DG  +  S    + +     R +L +PA    + G +   A + S   T T    
Sbjct: 37   VSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELL 96

Query: 1075 ----TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
                TAPP  +     +S+ +  G+  R+++R    P    V++Y+DG E+++S   Q+ 
Sbjct: 97   VKAETAPPNFVQR--LQSMTVRQGSQVRLQVRVTGIPT-PVVKFYRDGAEIQSSLDFQIS 153

Query: 1131 AEGPTRTLTLPHAQPEDAGEY 1151
             EG   +L +  A PED+G Y
Sbjct: 154  QEGDLYSLLIAEAYPEDSGTY 174



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 71/338 (21%), Positives = 130/338 (38%), Gaps = 44/338 (13%)

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
             G+   L I  A   D G+  C ++   G  +    L + +       +  +APA + +P 
Sbjct: 33089 GSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSK-------ELSDAPAFISQP- 33140

Query: 249   KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
                 ++  +NEG++  F C + G+P PEIEW     P+       + R R+  + L++  
Sbjct: 33141 ----RSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRN-VYSLEIRN 33195

Query: 309   CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
                 D G Y   A+N  GQ  +   L V         P ++V  R  G   L+    +  
Sbjct: 33196 ASVSDSGKYTIKAKNFRGQCSATASLMVLP---LVEEPSREVVLRTSGDTSLQGSFSSQS 33252

Query: 369   IPTAWFREDQRL----------LPCRKYEQIEE---GTVRRLIIHRLKADDDGI-YLCEM 414
             +  +  +++             +   K+  +      +++   +    +   GI  + ++
Sbjct: 33253 VQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQL 33312

Query: 415   RGRVRTVANVTVKG--PILKRLPRKLDVLEGE-NAVLLVETLEAGVEGRWSRDGEELPVI 471
                   +    ++G  P ++ LP  + + EG+   V    T E   E  WS  G +   I
Sbjct: 33313 ESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRK---I 33369

Query: 472   CQSSSGHMH--------ALVLPGVTREDAGEVTFSLGN 501
                  G  H         L++  V ++D G  T SLGN
Sbjct: 33370 HSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 33407



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 97/418 (23%), Positives = 155/418 (37%), Gaps = 52/418 (12%)

Query: 373   WFREDQRLLPCRKYEQIEEGTVR-RLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
             W R + R +   K++ +EEG V  +  + R++A    +    +        NV  K P  
Sbjct: 14331 WMRVNSRPIKDLKFK-VEEGVVPDKEYVLRVRA----VNAIGVSEPSEISENVVAKDPDC 14385

Query: 432   KRL----PRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHA---LV 483
             K         + V+EGE   + V      V    W +DG+E+    + +  + H    L 
Sbjct: 14386 KPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLE 14445

Query: 484   LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP 543
             +P   R DAG  T +L N   +    +       PGP    +     K++  LTW+PPE 
Sbjct: 14446 VPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEF 14505

Query: 544   APETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
                TP + Y LER+E G   +I   S E   +  V  D +P+ G+Y FR+  V+  G   
Sbjct: 14506 DGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVK-DLIPN-GEYFFRVKAVNKVGGGE 14563

Query: 603   HVVFHGSAHLV----------------PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG- 645
             ++                         PTA  +       +YDG   +    +  I +G 
Sbjct: 14564 YIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGE 14623

Query: 646   -TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD 704
               W    E L             L Y    KGL+           ++ A +         
Sbjct: 14624 ERWKRCNEHLVP----------ILTY--TAKGLEEGKEYQFRVRAENAAGISEPSRATPP 14671

Query: 705   SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESEL 761
             + A+   ++P  IL    R SL     + + L   +S   +P  TW KD   +   E+
Sbjct: 14672 TKAVDPIDAPKVIL----RTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEI 14725



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 24/209 (11%)

Query: 413   EMRGRVRTVANVTVKGP-------ILKRLPRKLDVLEGENAVLLVET-----LEAGVEGR 460
             + R   RT  N++           + + +P ++D+     ++L V+      L+A V G+
Sbjct: 19263 QFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGK 19322

Query: 461   ------WSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 511
                   W +DG  L     I  +   ++  L L  V R+D+G+ T +  NS  +    +K
Sbjct: 19323 PMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIK 19382

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPP-EPAPETPFIYRLERQEVGSEDWIQCFSIE 570
                   PGPP   ++ K + +  +L+W+PP E        Y ++++E    +W Q  +  
Sbjct: 19383 LKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATV 19442

Query: 571   KAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                +  V  + +    +Y+FRIC  + +G
Sbjct: 19443 PITSCSV--EKLIEGHEYQFRICAENKYG 19469



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 100/471 (21%), Positives = 191/471 (40%), Gaps = 59/471 (12%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G+ A+  C ++G+P P+I+W+  G+ L+  R+  M  D      L V+  + +D G+Y C
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSD-GRTHTLTVMTEEQEDEGVYTC 30605

Query: 320   AARNSAGQTLSAVQLHVK-EPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFRED 377
              A N  G+  ++ +L ++  P+     PL++   G       L        +P   +   
Sbjct: 30606 IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHG 30665

Query: 378   QRLLPCRKYEQIEE-----GTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKG-PIL 431
             Q+LL   +   IE        V + +  +  A    + L  + G V  + +V ++  P  
Sbjct: 30666 QKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDK 30725

Query: 432   KRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVT--- 488
                P  ++ L   +AV+  +   A   G W  +   +   C++  G    LV   ++   
Sbjct: 30726 PTGPIVIEALLKNSAVISWKP-PADDGGSWITN--YVVEKCEAKEGAEWQLVSSAISVTT 30782

Query: 489   ------REDAG-------EVTFSLGNS---RTTTLLRVKCVKHSPPGPPILAEMFKGHKN 532
                    E+AG       + TF + +     +  +++    K   PG P +  +    K+
Sbjct: 30783 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAV---TKD 30839

Query: 533   TVLLTWKPPEPAPETPF-IYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DYRF 590
             + ++ WKPP          Y LE++E     WI   + E    V    + +  EG +Y F
Sbjct: 30840 SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLI--EGLEYEF 30897

Query: 591   RICTVSGHGRS-----PHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS----T 641
             R+   +  G S        +   S   +        L ++ V    +A     ++     
Sbjct: 30898 RVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKP 30957

Query: 642   IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQ-KGLQHRLILHAVKHQDS 691
             I++  W+  G+E+ ++          L+YRI++ KG  H+LI+ +V   D+
Sbjct: 30958 IVK--WYRQGKEIIAD---------GLKYRIQEFKGGYHQLIIASVTDDDA 30997



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 54/214 (25%), Positives = 86/214 (40%), Gaps = 27/214 (12%)

Query: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD-EVWDSSHFALQPGRAE 185
           AP F    +S  VL G+         G P P + W +DG  +          +   GRA+
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64

Query: 186 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
                   L I A    +SG Y   A N  G A + A L V           + AP   V
Sbjct: 65  --------LTIPAVTKANSGRYSLKATNGSGQATSTAELLV---------KAETAPPNFV 107

Query: 246 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 305
           + L    ++  V +G   + +  V G P P ++++ +G  +   +  L ++    G +  
Sbjct: 108 QRL----QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI---QSSLDFQISQEGDLYS 160

Query: 306 VLYCQA--KDRGLYVCAARNSAGQTLSAVQLHVK 337
           +L  +A  +D G Y   A NS G+  S  +L V+
Sbjct: 161 LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 34/119 (28%), Positives = 55/119 (46%), Gaps = 9/119 (7%)

Query: 7     DQGSPPCFLRFPR---PVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD 63
             D+  PP     P+    + V +G   ++   + G+P P + W KG Q+L+ + RL   + 
Sbjct: 22536 DEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKST 22595

Query: 64    GAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
                  L +  A+  D+G Y+ +A+N AGE      V VL+ P       P E P+   G
Sbjct: 22596 DFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG------PPEGPVVISG 22648



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 28/92 (30%), Positives = 48/92 (52%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
           +PP F++  + + V  G++  L+  V G P PVV + + G ++ +S       +G  + L
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSL 161

Query: 70  LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
           L+  A P D+G Y   A N+ G A + A + V
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 195/938 (20%), Positives = 327/938 (34%), Gaps = 198/938 (21%)

Query: 713  SPVHI-LSPQDRVS----LTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKM 766
            +PV I ++P   VS    +T    E V L C +S    P  TWY++  ++E S    +  
Sbjct: 934  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993

Query: 767  DGRKHRLILPEA-------------------------KVQDSGEFECRTEGVSAFFGVT- 800
                 RL++ EA                          VQ S EFE  T  V+  F    
Sbjct: 994  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1053

Query: 801  ---VQDPPVHIVD---------PREHVFVHAITSECV---------MLACEVDREDAP-V 838
               V+   V + D         P E    + IT   V         +  C+V     P V
Sbjct: 1054 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV 1113

Query: 839  RWYKDGQEVEESDF--VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI---- 892
             W K G  +       V    +    +LV+  T   D GE+  V  ++    + +     
Sbjct: 1114 YWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLE 1173

Query: 893  -----------------TDVSSWIVYPS------GKVYVAAVR---LERVVLTCELCRPW 926
                             T V++++  P       G VY    +    E+ ++  ++ +  
Sbjct: 1174 EADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDT 1233

Query: 927  AEVR-WTKDGEEVVESPALLLQKEDTVRRLVLPAVQL-EDSGEYLCEIDDESASFTVTVT 984
              VR + +D E  + S    L KE   R +     +L E+ GE    +D   +    +  
Sbjct: 1234 VVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGF 1293

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLE--RDG 1041
            +  ++     + +         V   C++S    P + WYKDG  ++  E   ++  +DG
Sbjct: 1294 DSRIKNYRILEGMG--------VTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1345

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             R  L +P   PED G +   A +             +  V PAA       GAP  +  
Sbjct: 1346 -RASLRIPVVLPEDEGIYTAFASNIKG----NAICSGKLYVEPAA-----PLGAPTYIPT 1395

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
               V+   S          +  S A    A      ++     P    E   E++ E + 
Sbjct: 1396 LEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERL- 1454

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV---VWSHNGRP-VQEGE 1217
            +  +    PV F  LE   +              +L   G P+    W H+G+  V +  
Sbjct: 1455 YKPVFVLKPVSFKCLEGQTARF------------DLKVVGRPMPETFWFHDGQQIVNDYT 1502

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYT--CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
               +  E   + L I  A P+ +G +T   Q+ A   + S+  TV+  E  V+ +  E  
Sbjct: 1503 HKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKL 1562

Query: 1276 QTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA--SQGRVQLEQAGARQVLRVQGAR 1332
            +  V    G  LE+ V  +G P   + W K+ + +      ++++E       L++    
Sbjct: 1563 K-NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTV 1621

Query: 1333 SGDAGEY----LCDAPQDSRIFLVSVE-----------------------------EPLL 1359
            S D+  Y    +  A +D+    V+VE                             EPL 
Sbjct: 1622 SQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLH 1681

Query: 1360 VKLVSE---------------------LTPLTVHEGDDATFRCEVSP---PDADVTWLRN 1395
            ++   E                     LT L +     A F C ++P   P   V WL +
Sbjct: 1682 LRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHD 1741

Query: 1396 GAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLF 1451
            G  +    ++ M        L        D+G +T RA    G+  TSA L V++ + L 
Sbjct: 1742 GKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSL- 1800

Query: 1452 LRRLQDVRAEEGQDVCLEV-ETGRVGAAGAVRWVRGGQ 1488
               +++ +  EG+     + E  R+   GA+  V   Q
Sbjct: 1801 ---VEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQ 1835



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 67/309 (21%), Positives = 111/309 (35%), Gaps = 55/309 (17%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA----------EDGP 188
            +L G  V   C+  G P P + W KDG  +          LQ GRA          ++G 
Sbjct: 1302 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1361

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ----PPESPPADPDEAPAPV 244
              + A  I    +    +YV  A           L  V +     P S    P       
Sbjct: 1362 YTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR 1421

Query: 245  VEPLKCAPK----------------------------------TFWVNEGKHAKFRCYVM 270
            + P + +P                                   +F   EG+ A+F   V+
Sbjct: 1422 MSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVV 1481

Query: 271  GKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLS 330
            G+P PE  W  +G+ ++ D    +    DG   L ++     D G +   A+N AG++  
Sbjct: 1482 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1541

Query: 331  AVQLHVK----EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRK 385
            +V L V+    + +  F   L++V  +E     ++ +   +  P   W +    ++P  K
Sbjct: 1542 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVP-HK 1600

Query: 386  YEQIE-EGT 393
            Y +I  EGT
Sbjct: 1601 YPKIRIEGT 1609



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 1/93 (1%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             +++++G    +  VV G P P  VW K   +L   +R+     G +  L++  AL  D G
Sbjct: 15114 IQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELD-KDRVVIDNVGTKSELIIKDALRKDHG 15172

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
              YV  A N+ G  +AAA V V + P    +L+P
Sbjct: 15173 RYVITATNSCGSKFAAARVEVFDVPGPVLDLKP 15205



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 1/105 (0%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             S +    P F+  PR   +  G      C + GEP P + W K    ++ S  +S     
Sbjct: 33127 SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR 33186

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP 109
               + L +  A  +D+G Y  +A+N  G+  A A++ VL P   +P
Sbjct: 33187 NVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL-PLVEEP 33230



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 45/157 (28%), Positives = 63/157 (40%), Gaps = 16/157 (10%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + V + +GA   L   V G PPPV+ W K G  LA+  R       +   L++      D
Sbjct: 29454 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYD 29511

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS-------PGSGEGAPV-- 129
             AG Y   A N +G+  A   V V + P   P ++  E    S       P    GAPV  
Sbjct: 29512 AGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNN 29571

Query: 130   FLTGPRSQWVLRGAEVVLTC-----RAGGLPEPTLYW 161
             ++   R   +     V   C     R  GL E T+Y+
Sbjct: 29572 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYY 29608



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 13/178 (7%)

Query: 1640 VTEGDTATFECELSQ-ALADVTWEKDGNALTPS--PRLRLQALGTRRLLQLRRCGPSDAG 1696
            V EG TATFE  +S   + +V+W +DG  ++ S  P +++     R  L +     +++G
Sbjct: 17   VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76

Query: 1697 TYSCAV--GTARA-GPVRLTVRERTVA--VLSELRSVSAREGDGATFECTVSEVET-TGR 1750
             YS     G+ +A     L V+  T     +  L+S++ R+G     +  V+ + T   +
Sbjct: 77   RYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVK 136

Query: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVE 1804
            +   G  ++     +I QEG  + L+++E   ED+G     A    G A S A L V+
Sbjct: 137  FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 4/97 (4%)

Query: 11    PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
             PP F        V++G + ++    +G P P V W K    L  + R++  A+  E+  L
Sbjct: 22147 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN--AESTENNSL 22204

Query: 71    LTA--ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             LT   A   D G YV +  N+AGEA     V VL+ P
Sbjct: 22205 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 22241



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 58/264 (21%), Positives = 108/264 (40%), Gaps = 22/264 (8%)

Query: 1631  IVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRR 1689
             IV G  D  V+    A F  + + +      W KDG A+T   + +L        L++ +
Sbjct: 32854 IVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHK 32913

Query: 1690  CGPSDAGTYSCAVGTARAGPVRLTVRERTVAVL-SELRSVSAREGDGATFECTVSEVETT 1748
                SD+G Y+C V  + AG V  + +    A+  +E + VS ++    T E T  + +  
Sbjct: 32914 TDTSDSGLYTCTVKNS-AGSVSSSCKLTIKAIKDTEAQKVSTQK----TSEIT-PQKKAV 32967

Query: 1749  GRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE--DAGEVRFQAGPAQSLALLEVEAL 1806
              + E+  + LR    +++ +   +  L L E  ++   + EV+  A  +   +++  E  
Sbjct: 32968 VQEEISQKALR-SEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEIT 33026

Query: 1807  PLQMCRHPPR----------EKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEM 1856
                      R          + ++  G+R VL+  ++     V W+  G EL   ++Y  
Sbjct: 33027 KTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDVKWVLNGVELTNSEEYRY 33085

Query: 1857  RSHGPTHSLVIHDVRPEDQGTYCC 1880
                G   +L I      D+G   C
Sbjct: 33086 GVSGSDQTLTIKQASHRDEGILTC 33109



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 180/863 (20%), Positives = 317/863 (36%), Gaps = 125/863 (14%)

Query: 228   QPPESPPADP--DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
             +P ES  A    DE   P +        T  V+ G+  K    + GKP P I+W  +G  
Sbjct: 22524 EPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWI-KGDQ 22582

Query: 286   LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV--------- 336
              L +  RL  +  D    L V      D G Y+  A+N AG+    V + V         
Sbjct: 22583 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 22642

Query: 337   ---------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYE 387
                      ++  L +  PLQD  G    I  +  +   SR+       + + L C+  +
Sbjct: 22643 PVVISGVTAEKCTLAWKPPLQD--GGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 22700

Query: 388   QIE--EGTVRRLIIHRLKADDD---------GIYLCEMRGRVRTVANVTVKGPILKRLPR 436
              +E  E T R + +++    +            ++     +   V  VT    I+     
Sbjct: 22701 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVW--- 22757

Query: 437   KLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHALVLPGVTRED---- 491
             +    +G + +L     +   EG RW+R  + L        G +   V   +   D    
Sbjct: 22758 ERPASDGGSEILGYVLEKRDKEGIRWTRCHKRL-------IGELRLRVTGLIENHDYEFR 22810

Query: 492   -AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP--EPAPETP 548
              + E    L      +  +  C     PGPP   ++    +++V L+W  P  +   E  
Sbjct: 22811 VSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQ 22870

Query: 549   FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHG 608
               Y +E+ +V   +W  C          +  + +  + +Y FRIC ++  G   H    G
Sbjct: 22871 G-YIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPG 22929

Query: 609   SAHLVPTARLVAGLEDVQV----YDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
                ++   +L A   D+ +         A  SL L   I+G       E+K  + +G++ 
Sbjct: 22930 P--IIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGR---PTPEVKWGKVDGEIR 22984

Query: 665   PGALRYRIEQKGLQHRLILHAVKHQDSG--ALVGFSCPGVQDSAALTIQ--ESPVHILSP 720
               A+   I+       L+L  V   DSG   L   +  G + SA +T++  ++P    SP
Sbjct: 22985 DAAI---IDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTK-SAFVTVRVLDTP----SP 23036

Query: 721   QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAK 779
                + +T  T + V +T E   +D        G K++    +V K +  RK    +    
Sbjct: 23037 PVNLKVTEITKDSVSITWEPPLLD-------GGSKIK--NYIVEKREATRKSYAAVVTNC 23087

Query: 780   VQDSGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDRE 834
              ++S + +   EG S +F VT ++      P    DP +   V     +  +   +V R 
Sbjct: 23088 HKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGK--ITVDDVTRN 23145

Query: 835   DAPVRWYK----DGQEVEESDFVVLENEGPH----------RRLVLPATQPSDGGE--FQ 878
                + W K     G ++ +    ++E +  H          + L    T  + G E  F+
Sbjct: 23146 SVSLSWTKPEHDGGSKIIQ---YIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFR 23202

Query: 879   CVAGDE--------CAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVR 930
              VA +E         A   V    V    V P+   Y   V  +  +      RP   + 
Sbjct: 23203 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 23262

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY----LCEIDDESASFTVTVTEP 986
             WTKDG  + ++  + +     +  L +     +D G+Y       +  ++AS  +   + 
Sbjct: 23263 WTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 23322

Query: 987   PVRIIYPRDEVTLIAVTLECVVL 1009
             P     P+  V    V+ E + L
Sbjct: 23323 PDP---PKGPVKFDDVSAESITL 23342



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 44/198 (22%), Positives = 77/198 (38%), Gaps = 24/198 (12%)

Query: 1100  ELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHE 1158
             +L C++       ++WY+ G E+  S   ++ ++G T TLT+   + ED G Y C     
Sbjct: 30551 QLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC----- 30605

Query: 1159  AITFNVILAEPPVQFLALETTPSPLCVAPGEPV----------VLSCELSRAGAPV---V 1205
              I  N +        L L+ TP      PG P+           L   +   G PV    
Sbjct: 30606 -IATNEVGEVETSSKLLLQATPQ---FHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661

Query: 1206  WSHNGRPVQEGEGLEL-HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
             W H  + +Q  E + + + E    ++        HAG Y  Q     G       V++ +
Sbjct: 30662 WFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 30721

Query: 1265  PPVRVVAPEAAQTRVRST 1282
              P +   P   +  ++++
Sbjct: 30722 KPDKPTGPIVIEALLKNS 30739



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 40/149 (26%), Positives = 68/149 (45%), Gaps = 13/149 (8%)

Query: 925  PWAEVRWTKDGEEVVES--PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVT 982
            P  EV W +DG+ +  S  P + +   D   +L +PAV   +SG Y  +  + S   T T
Sbjct: 33   PVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATST 92

Query: 983  V-------TEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEA 1034
                    T PP   +     +T+   +   V L   ++    PV ++Y+DG E++ S  
Sbjct: 93   AELLVKAETAPP-NFVQRLQSMTVRQGSQ--VRLQVRVTGIPTPVVKFYRDGAEIQSSLD 149

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
              + ++G    L++  A PED G +  +A
Sbjct: 150  FQISQEGDLYSLLIAEAYPEDSGTYSVNA 178



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 75/330 (22%), Positives = 128/330 (38%), Gaps = 32/330 (9%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIE-KAG 573
             SPP PP+   +    +  + + WKPPE    +P I Y +E   VG+E W++  S   K  
Sbjct: 14283 SPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDL 14342

Query: 574   AVEVPGDCVPSEGDYRFRICTVSGHGRS-PHVVFHGSAHLVPTARLVAGLE--DVQVYDG 630
               +V    VP + +Y  R+  V+  G S P  +        P  +    LE  D+ V +G
Sbjct: 14343 KFKVEEGVVPDK-EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEG 14401

Query: 631   EDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKH 688
             E     +    +   T  W  +G+E+K+++          R  ++   +   L +     
Sbjct: 14402 EKLSIPVPFRAVPVPTVSWHKDGKEVKASD----------RLTMKNDHISAHLEVPKSVR 14451

Query: 689   QDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD--FP 746
              D+G +   +      SA  +I    + +  P   +  +  T     LT E    D   P
Sbjct: 14452 ADAG-IYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTP 14510

Query: 747   ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFG-------- 798
                Y   ++       +  M G +++L      +  +GE+  R + V+   G        
Sbjct: 14511 ILHYVLERREAGRRTYIPVMSG-ENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 14569

Query: 799   -VTVQDPPVHIVDPREHVFVHAITSECVML 827
              V  QDP     DP   V VH  T+E + +
Sbjct: 14570 PVIAQDPK-QPPDPPVDVEVHNPTAEAMTI 14598



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 40/81 (49%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G   +++  VLG P P V W+KG Q L  ++R++F        L +   + +D+G Y  
Sbjct: 21079 AGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPL 21138

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
              ARN  GE      + V + P
Sbjct: 21139 TARNIVGEVGDVITIQVHDIP 21159



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 127/603 (21%), Positives = 215/603 (35%), Gaps = 98/603 (16%)

Query: 37    GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
             G P   V W K GQ L  + R++  +      L +  A   D G Y     N+AG     
Sbjct: 25420 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 25479

Query: 97    AAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQWVLRGAEVVLTCRAGGLP 155
               + VL+ P     ++  E    S       P +  G + S +++   E   T       
Sbjct: 25480 ITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTT------ 25533

Query: 156   EPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVY---VCHAR 212
                  W     A+                     A  +++I+  RL     Y   VC A 
Sbjct: 25534 -----WHIVSQAV---------------------ARTSIKIV--RLTTGSEYQFRVC-AE 25564

Query: 213   NAHG---HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFW---VNEGKHAKFR 266
             N +G   ++++ A+  V + P SPP  P      VV   K      W   VN+G      
Sbjct: 25565 NRYGKSSYSESSAV--VAEYPFSPPGPP--GTPKVVHATKSTMLVTWQVPVNDGGSRVIG 25620

Query: 267   CYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA------ 320
              ++  K    I W    + L+ D + +     D G + +         G+  C+      
Sbjct: 25621 YHLEYKERSSILWSKANKILIADTQ-MKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPV 25679

Query: 321   -ARNSA---GQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRE 376
              AR+     GQ      +  K   L++++P  D   +  G  V   ++P           
Sbjct: 25680 PARDPCDPPGQP-EVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELP----------- 25727

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-GPILKR-- 433
             D R L C  Y  I+E       +  L  D    +    R    +V+  +   GPI+ +  
Sbjct: 25728 DGRWLKCN-YTNIQETYFE---VTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDD 25783

Query: 434   --LPRKLDVLEGENAVLL----VETLEAGVEGR------WSRDGEELPVICQS---SSGH 478
                PR +  ++  + +++    V  + A + GR      W++DG E+    ++   S+ +
Sbjct: 25784 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN 25843

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLT 537
                L +    R D G+   +L N   T  + V C     PGPP       G       L+
Sbjct: 25844 HTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 25903

Query: 538   W-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS 596
             W +P E        Y +E++E     W  C    +  + +V    +    +Y FR+  V+
Sbjct: 25904 WGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTK--LLKGNEYIFRVTGVN 25961

Query: 597   GHG 599
              +G
Sbjct: 25962 KYG 25964



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 24/85 (28%), Positives = 43/85 (50%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             V + +G++  L   V G+P P ++W KG ++L   E++S    G     ++     +D+G
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSG 29116

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y    +NA+G    +  V VL+ P
Sbjct: 29117 KYTLTVKNASGTKAVSVMVKVLDSP 29141



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 87/433 (20%), Positives = 168/433 (38%), Gaps = 45/433 (10%)

Query: 516   SPPGPPILA-EMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAG 573
             +PP PP    E+    K++V L+W +P +        Y +ER+E  ++ W++    +   
Sbjct: 30327 NPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 30386

Query: 574   AVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLE--DVQVYDGE 631
              +      VP + +Y+FRI   +  G S            P +  V   +  D     GE
Sbjct: 30387 TMYTVTGLVP-DAEYQFRIIAQNDVGLS---------ETSPASEPVVCKDPFDKPSQPGE 30436

Query: 632   DAVFSLDLSTII--------QGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLIL 683
               + S+   ++          G   + G  ++  +        + + RI+ K      +L
Sbjct: 30437 LEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLL 30496

Query: 684   HAVKHQD---SGALVGFSCP---GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
              A +++    +    G S P    +     LT  E+P      +D   +T    E   L+
Sbjct: 30497 EATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD---VTTKLGEAAQLS 30553

Query: 738   CELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC----RTEG 792
             C++     P   WY+ G+++ +S    +  DGR H L +   + +D G + C        
Sbjct: 30554 CQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGE 30613

Query: 793   VSAFFGVTVQ-DPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESD 851
             V     + +Q  P  H   P +  +  A+ S   +    + R    + W+   + ++ S+
Sbjct: 30614 VETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSE 30673

Query: 852   FVVLENEGPHRRLVLPATQ-PSDGGEFQC----VAGDECAYFTVTITDVSSWIVYPSGKV 906
              + +EN   +  LV+   Q  +  G+++     V G   A   V I D       P+G +
Sbjct: 30674 NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPD---KPTGPI 30730

Query: 907   YVAAVRLERVVLT 919
              + A+     V++
Sbjct: 30731 VIEALLKNSAVIS 30743



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 42/188 (22%), Positives = 74/188 (39%), Gaps = 10/188 (5%)

Query: 1638  LEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             + + EG     +  ++ A  DV W  +G  LT S   R    G+ + L +++    D G 
Sbjct: 33048 MSINEGQRLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGI 33106

Query: 1698  YSCAVGTARAGPVR----LTVRER---TVAVLSELRSVSAREGDGATFECTVS-EVETTG 1749
              +C +   + G V+    LT+ +      A +S+ RS +  EG    F C +S E     
Sbjct: 33107 LTC-ISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEI 33165

Query: 1750  RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
              W     P+   + V I +    + L +      D+G+   +A   +         + L 
Sbjct: 33166 EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP 33225

Query: 1810  MCRHPPRE 1817
             +   P RE
Sbjct: 33226 LVEEPSRE 33233



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 2/100 (2%)

Query: 8     QGSPPCFL--RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA 65
             Q +P  FL  +    + V +G + EL   V G+P P + W K    L   +R++      
Sbjct: 13685 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPK 13744

Query: 66    EHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             +  + +  +  +D G Y+  A N  G A A   V VL+ P
Sbjct: 13745 KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP 13784



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/147 (23%), Positives = 67/147 (45%), Gaps = 6/147 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DG+ L    +   SSS  + +L +   ++ED G     + NS  +  + +  +    
Sbjct: 25428 WRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDR 25487

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP    + +   +++ ++W PPE         Y +E++E  S  W          +++
Sbjct: 25488 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 25547

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH 603
             +      SE  Y+FR+C  + +G+S +
Sbjct: 25548 IVRLTTGSE--YQFRVCAENRYGKSSY 25572



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 60/268 (22%), Positives = 101/268 (37%), Gaps = 48/268 (17%)

Query: 1300  VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQD-------SRIFLV 1352
             V WY    +L +  + ++       +L V+     D G Y C    D       + +F+ 
Sbjct: 31600 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 31659

Query: 1353  SVEEPL-------------------LVKLVSELT-PL---TVHEGDDATFRCEVSP-PDA 1388
              V E                     L++   E T PL   T + G++  F   ++  P+ 
Sbjct: 31660 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 31719

Query: 1389  DVTWLRNGAVVTPGPQVEMAQNGSSR---ILTLRGCQLGDAGTVTLRA----GSTATSAR 1441
              VTW ++G  + PG   +     S +    LT+      D    T+ A    G  +  A+
Sbjct: 31720 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 31779

Query: 1442  L----HVRETEL----LFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHD 1493
             L    H   T+     +F R L +   +EGQ VC E+    +     ++W + GQPL   
Sbjct: 31780 LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGI-PPPTLKWEKDGQPLSLG 31838

Query: 1494  SRLSMAQDG-HIHRLFIHGVILADQGTY 1520
               + +  +G   + L I   +  D G Y
Sbjct: 31839 PNIEIIHEGLDYYALHIRDTLPEDTGYY 31866



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 19/187 (10%)

Query: 1725 LRSVSAREGDGATFECTVS-----EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
            L+SV   EG  ATFE  +S     EV      ++      PG ++    +G+  + + + 
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDGRAKLTIPAV 70

Query: 1780 LRAEDAGEVRFQA----GPAQSLA--LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS 1833
             +A ++G    +A    G A S A  L++ E  P    +   +  TV  G +  L+V V+
Sbjct: 71   TKA-NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL-QSMTVRQGSQVRLQVRVT 128

Query: 1834 RSGGHVC-WLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTH 1888
                 V  + R+GAE+     +++   G  +SL+I +  PED GTY   A    G+ ++ 
Sbjct: 129  GIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATST 188

Query: 1889 TRLLVEG 1895
              LLV+G
Sbjct: 189  AELLVQG 195



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 5/88 (5%)

Query: 1812  RHPPREKTVLVGRRAVLEVT-VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDV 1870
             R   ++ T  +G  A L    V R    + W R G EL    KY+M S G TH+L +   
Sbjct: 30536 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTE 30595

Query: 1871  RPEDQGTYCC----QAGQDSTHTRLLVE 1894
               ED+G Y C    + G+  T ++LL++
Sbjct: 30596 EQEDEGVYTCIATNEVGEVETSSKLLLQ 30623



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 25/93 (26%), Positives = 44/93 (47%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V+ G +  +       P P V W K G+++ AS+RL+   D     L +  ++  DAG+Y
Sbjct: 14398 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 14457

Query: 83    VCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
                  N  G A A+  V V+  P    +++ ++
Sbjct: 14458 TITLENKLGSATASINVKVIGLPGPCKDIKASD 14490



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 26/85 (30%), Positives = 40/85 (47%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             + V  G    +   V G P P + W K G+ L   +R+    D     L +  A+  D G
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 17977

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y+  A+N++G A  +A V VL+ P
Sbjct: 17978 KYIISAKNSSGHAQGSAIVNVLDRP 18002



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 33/101 (32%), Positives = 42/101 (41%), Gaps = 2/101 (1%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVW--EKGGQQLAASERLSFPADG 64
             D   P   L+    + V +G    L+  V G+P P V W  +K    L  S R+      
Sbjct: 18197 DLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA 18256

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                   LT A  +D G YV  A N AG   A A V VL+ P
Sbjct: 18257 DSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKP 18297



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 40/149 (26%), Positives = 63/149 (42%), Gaps = 8/149 (5%)

Query: 461   WSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             WS+ G+++    +   +S+     L +   TR+DAGE T +  N   T +  VK      
Sbjct: 20413 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDV 20472

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-IYRLERQEVGSEDW-IQCFSIEKAGAV 575
             PGPP   E+         LTW PP     +P   Y LE++E     W +    I+    V
Sbjct: 20473 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHV 20532

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                   +    +Y FR+  V+ +G+   V
Sbjct: 20533 ATK---LIQGNEYIFRVSAVNHYGKGEPV 20558



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 248   LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKV 306
             ++  P    ++EGK     C   G+P PE+ W   GR +   ++ R    + D    L +
Sbjct: 33331 IEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLII 33390

Query: 307   LYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             +  Q +D GLY  +  N  G   + V +H++
Sbjct: 33391 MDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 83/382 (21%), Positives = 142/382 (37%), Gaps = 51/382 (13%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             LV+    R D G  T  L N   T    +     + P  P   +     K++V LTW+PP
Sbjct: 13452 LVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPP 13511

Query: 542   EPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS--GH 598
             +    +P   Y +E++EV  + W +           VP D V  + +Y F++C  +  G 
Sbjct: 13512 DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP-DLVQGK-EYLFKVCARNKCGP 13569

Query: 599   GRSPHV---VFHGSAHLVP-----------TARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
             G   +V   V   +   VP           TA  +    D    DG   +    +    +
Sbjct: 13570 GEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPR 13629

Query: 645   GT--WFLNGEELKSNEPE--GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP 700
             G+  W   GE +   + E  G  E     YR++    Q                 G S P
Sbjct: 13630 GSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQ-----------------GASKP 13672

Query: 701   G--VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVE 757
                 ++  A+  QE+P   L  +    LT     ++ L   ++    P  TW K    ++
Sbjct: 13673 SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILK 13732

Query: 758   ESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDPPVHIVDPRE 813
             + + + ++   +K  + + ++K  D+G +      V    +A   V V D P     P  
Sbjct: 13733 QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP----GPPA 13788

Query: 814   HVFVHAITSECVMLACEVDRED 835
                +  +T+E  +L     R+D
Sbjct: 13789 AFDITDVTNESCLLTWNPPRDD 13810



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 38/163 (23%), Positives = 62/163 (38%), Gaps = 16/163 (9%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
             +Q  PP  L  P  + + +G +  ++  V G+P P   W+KG  ++  S  L+     + 
Sbjct: 18895 EQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS 18953

Query: 67    HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS----------DPELQPAER 116
               L++      D+G Y   A N++G       V V++ P            D +      
Sbjct: 18954 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSW 19013

Query: 117   PLPSPGSGEGAPVFLTG----PRSQWVLRGAEVVLT-CRAGGL 154
              +P    G     ++       R  WV   A V  T CR G L
Sbjct: 19014 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKL 19056



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 117/570 (20%), Positives = 217/570 (38%), Gaps = 77/570 (13%)

Query: 345   RPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLK 403
             + ++DV  +    A L C++    +P   W+R  + L+  RKY+   +G    L +   +
Sbjct: 30537 KEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEE 30596

Query: 404   ADDDGIYLCEMRGRVRTVANVTVKGPILKRLPR---------KLDVLEGENAVLLVETLE 454
              +D+G+Y C     V  V   T    +L+  P+         K     G    L V  + 
Sbjct: 30597 QEDEGVYTCIATNEVGEVE--TSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIG 30654

Query: 455   AGVEGRWSRDGEEL----PVICQSSSGHMHALVLPGVTRED-AGEVTFSLGNSRTTTL-- 507
               V       G++L      I   ++ H   LV+  V R+  AG+    L N   T    
Sbjct: 30655 RPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAI 30714

Query: 508   --LRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE-----TPFIYRLERQEVGS 560
               + ++     P GP ++  + K   N+ +++WKP  PA +     T ++      + G+
Sbjct: 30715 LDVEIQDKPDKPTGPIVIEALLK---NSAVISWKP--PADDGGSWITNYVVEKCEAKEGA 30769

Query: 561   EDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP-----HVVFHGSAHLVPT 615
             E W    S        +    +     Y FR+   +  G S       VV   S    P 
Sbjct: 30770 E-WQLVSSAISVTTCRIVN--LTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG 30826

Query: 616   ARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT----WFLNGEELKSNE----PEGQVEPGA 667
             A    G   +     +  V +        G     ++L   E K N+       ++    
Sbjct: 30827 A---PGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETV 30883

Query: 668   LRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSP---QDRV 724
                +   +GL++      VK ++ G    +S    + S  +T  +S V I +P   ++  
Sbjct: 30884 FSVKNLIEGLEYEF---RVKCENLGGESEWS----EISEPIT-PKSDVPIQAPHFKEELR 30935

Query: 725   SLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELL--VVKMDGRKHRLILPEAKVQ 781
             +L         L C+++    P   WY+ G+++    L   + +  G  H+LI+      
Sbjct: 30936 NLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDD 30995

Query: 782   DSGEFECRTEG----VSAFFGVTVQDPP-VHIVDPREHV-FVHAITSECVMLACEVDRED 835
             D+  ++ R       VS    + V+ P  +H+    E +  VHA+  E V +      + 
Sbjct: 30996 DATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKP 31055

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLV 865
              PV  ++ GQ+       +++N G ++ +V
Sbjct: 31056 DPVITWQKGQD-------LIDNNGHYQVIV 31078



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 60/287 (20%), Positives = 101/287 (35%), Gaps = 49/287 (17%)

Query: 1461  EEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
             EEG  V    +      +  V W  G + L +  +  +  +  +  L++  +   D GTY
Sbjct: 31580 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 31639

Query: 1521  GCESHHD------------------------RTLARLSVRPRQLRVLRPLEDVTISEGGS 1556
              C+  +D                        RT+ ++  R   +R+L    + T+     
Sbjct: 31640 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 31699

Query: 1557  ATFQLELSQEGVT--------GEWARGGVQLYPG---PKCHIHSDGHRHRLVLNGLGLAD 1605
               +  E  + GVT          W + G ++ PG    K    SD   ++L +N +   D
Sbjct: 31700 TAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDD 31759

Query: 1606  SGCVSFTA------DSLRCAARLIVREVPVTIVRGP------HDLEVTEGDTATFECELS 1653
                 +  A      DS +    + +   P      P       + E  EG +  FE  +S
Sbjct: 31760 DAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVS 31819

Query: 1654  Q-ALADVTWEKDGNALTPSPRLRLQALG-TRRLLQLRRCGPSDAGTY 1698
                   + WEKDG  L+  P + +   G     L +R   P D G Y
Sbjct: 31820 GIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 31866



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 6/107 (5%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             +F   + V +G    L+  V G+P P + W +G +++  S R        +  L++  A+
Sbjct: 23630 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAI 23689

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
               D G Y+ RA N AG       V VL+ P       P E P+   G
Sbjct: 23690 RIDGGQYILRASNVAGSKSFPVNVKVLDRPG------PPEGPVQVTG 23730



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 17/180 (9%)

Query: 1284 GGDLELVVHLSG-PGGPVRWYKDGERLASQGR--VQLEQAGARQVLRVQGARSGDAGEYL 1340
            G       H+SG P   V W++DG+ +++     VQ+  +  R  L +      ++G Y 
Sbjct: 20   GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79

Query: 1341 CDAPQDSRIFLVSVEEPLLVK-------LVSELTPLTVHEGDDATFRCEVSP-PDADVTW 1392
              A   S     + E  LLVK        V  L  +TV +G     +  V+  P   V +
Sbjct: 80   LKATNGSGQATSTAE--LLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKF 137

Query: 1393 LRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETE 1448
             R+GA +      +++Q G    L +      D+GT ++ A    G   ++A L V+  E
Sbjct: 138  YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEE 197



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 23/75 (30%), Positives = 35/75 (46%)

Query: 31    LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAA 90
             LK  + G+P P V W+KG   LA   R+S  +      L++     +DAG Y    +N A
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061

Query: 91    GEAYAAAAVTVLEPP 105
             G      ++ V+  P
Sbjct: 20062 GTKEGTISIKVVGKP 20076



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 6/104 (5%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   V + +G    L+  V G PPP + W K G++L  + +L          L+   +
Sbjct: 21465 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDS 21524

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL 118
                D+G Y   A N  G A     V VL+ P       P E PL
Sbjct: 21525 TRRDSGAYTLTATNPGGFAKHIFNVKVLDRPG------PPEGPL 21562



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 1/89 (1%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G + ++     G PPP V W K  + L +  R S     +   L +      D G Y+ 
Sbjct: 27285 AGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYIL 27344

Query: 85    RARNAAGEAYAA-AAVTVLEPPASDPELQ 112
                N  GE  ++  +V VL+ PA+  +LQ
Sbjct: 27345 TIENGVGEPKSSTVSVKVLDTPAACQKLQ 27373



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 50/213 (23%), Positives = 75/213 (35%), Gaps = 40/213 (18%)

Query: 1721  VLSELRSVSAREGDGATFECTVSEVE--TTGRWELGGRPLRPGARVRIRQEGKKHILVLS 1778
             V  ++      EG    + C +   +  T   W  G R L    +  I  E    IL + 
Sbjct: 31570 VSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVK 31629

Query: 1779  ELRAEDAGEVRFQA----GPAQSLALLEVEAL--------------------PLQMCRHP 1814
             ++   D G  R +     G   S A L V+ +                     +++   P
Sbjct: 31630 DITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERP 31689

Query: 1815  PR------EKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGD---KYEMRSHGPTHS 1864
             P        KT  VG      VT++     HV W + G ++ PGD   KY   S    + 
Sbjct: 31690 PEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQ 31749

Query: 1865  LVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
             L I+ V  +D   Y   A    G+DS   +L V
Sbjct: 31750 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/91 (30%), Positives = 37/91 (40%), Gaps = 1/91 (1%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE-HGLL 70
             P F R         G     +  V G PPP + WEK GQ L+    +    +G + + L 
Sbjct: 31795 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 31854

Query: 71    LTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
             +   LP D G Y   A N AG     A + V
Sbjct: 31855 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 32/124 (25%), Positives = 53/124 (42%), Gaps = 3/124 (2%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             L +     ED G  + ++ N   +  + VK +    PGPP   E+ +  K++  LTWK P
Sbjct: 17274 LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEP 17333

Query: 542   -EPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
              +        Y +ER++V S  W    +  K  +       +     Y FR+   + +GR
Sbjct: 17334 LDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH--LNEGNQYLFRVAAENQYGR 17391

Query: 601   SPHV 604
              P V
Sbjct: 17392 GPFV 17395



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 8/90 (8%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP   E+    K+++ L WKPP     +P   Y +E QE G+ DW +   + +   +
Sbjct: 15704 PPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKR---VNEPDKL 15760

Query: 576   EVPGDCVPSE----GDYRFRICTVSGHGRS 601
                 +CV         YRFR+  V+  G S
Sbjct: 15761 ITTCECVVPNLKELRKYRFRVKAVNEAGES 15790



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 23/83 (27%), Positives = 32/83 (38%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G       ++ G P P   W   G ++   E  +   D     L +   L  D G Y
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEY 17581

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  NAAG    A  +TVL+ P
Sbjct: 17582 QITVSNAAGSKTVAVHLTVLDVP 17604



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/465 (21%), Positives = 172/465 (36%), Gaps = 60/465 (12%)

Query: 1021  RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
             +W  DG E++  E   +E D     L +      D GE+     + +   TV V      
Sbjct: 17543 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 17602

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAP--AGSQVRWYKDGLEVEASDALQLGAEGPTRT- 1137
             +  P    +++    P  + +  +      GS V  Y    +    D   + + G ++T 
Sbjct: 17603 VPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTK 17662

Query: 1138  LTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALE-----TTPSPLCVAPGEPVV 1192
             L +PH Q     EYV   R E    N I   PP+           + PSP    PG+PVV
Sbjct: 17663 LKIPHLQK--GCEYVFRVRAE----NKIGVGPPLDSTPTVAKHKFSPPSP----PGKPVV 17712

Query: 1193  LSCELSRAGAPVVW----SHNGRPVQ---------EGEGLELHAEGPRRVLCIQAAGPAH 1239
                +++   A V W    S  G P+           G+ + ++ + P   L  +  G   
Sbjct: 17713 T--DITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVN-KTPIADLKFRVTGLYE 17769

Query: 1240  AGLYTCQ------SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
                Y  +      +G +  +PS S  ++   P      P   + + +S    DL     L
Sbjct: 17770 GNTYEFRVFAENLAGLSKPSPS-SDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPL 17828

Query: 1294  SGPGGPVRWY-----KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----- 1343
             S  G P+  Y     K G   A   R+  ++   +   RV G   G+   +   A     
Sbjct: 17829 SDGGSPILGYVVECQKPGT--AQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 17886

Query: 1344  ---PQD--SRIFLVSVEEPLLVKL-VSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
                P++    +    +  P  V+L V+    +TV  G        V   P+ D+TW + G
Sbjct: 17887 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 17946

Query: 1397  AVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSAR 1441
              V+    +V++ Q+     L ++     D G   + A +++  A+
Sbjct: 17947 KVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQ 17991



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 72/378 (19%), Positives = 127/378 (33%), Gaps = 62/378 (16%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R + V +G    +   + G P P V W K    L    R +     +   L++      D
Sbjct: 20784 RTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINL--KNRANIENTESFTLLIIPECNRYD 20841

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQ 137
              G +V    N AG+      V VL+ P     L+P +    S       P+   G R + 
Sbjct: 20842 TGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITN 20901

Query: 138   WVLRGAEV-------------------------------VLTCRAGGLPEPTLYWEK--- 163
             +++   E                                V+     G+ EPT   E    
Sbjct: 20902 YIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 20961

Query: 164   -------DGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYV-------- 208
                    D + + ++  S+     P    DG G+ +   ++ A+   S  +         
Sbjct: 20962 SEAPSPPDSLNIMDITKSTVSLAWPKPKHDG-GSKITGYVIEAQRKGSDQWTHITTVKGL 21020

Query: 209   -CHARN-AHGHAQAGALLQVHQPPESPPADP------DEAPAPVVEPLKCAPKTFWVNEG 260
              C  RN   G      ++ V+    S P +       ++   P ++      K      G
Sbjct: 21021 ECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 21080

Query: 261   KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              + K    V+G+P+P + W  +G  +L   +R+ +       +L +  C   D G Y   
Sbjct: 21081 DNIKVEIPVLGRPKPTVTWK-KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 21139

Query: 321   ARNSAGQTLSAVQLHVKE 338
             ARN  G+    + + V +
Sbjct: 21140 ARNIVGEVGDVITIQVHD 21157



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 24/83 (28%), Positives = 39/83 (46%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + +G + +++  V+G P P + W K G+ L  + R++         L +      D G Y
Sbjct: 24323 IQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKY 24382

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A N+AG A    +V VLE P
Sbjct: 24383 TVTATNSAGTATENLSVIVLEKP 24405



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 22/92 (23%), Positives = 40/92 (43%)

Query: 10    SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
             S P  +   +   V S + A+      GEP P  +W K G+ +    +     D     L
Sbjct: 32850 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFL 32909

Query: 70    LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +     +D+G+Y C  +N+AG   ++  +T+
Sbjct: 32910 EIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 52/216 (24%), Positives = 87/216 (40%), Gaps = 29/216 (13%)

Query: 727 TFTTSERVVLTCELSRVDFPA----------TWYKDGQKVEESELLVVKM---DGRKHRL 773
           TFT   + V+  E S   F A          +W++DGQ +  S L  V++   DGR  +L
Sbjct: 7   TFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA-KL 65

Query: 774 ILPEAKVQDSGEFECRTEGVS------AFFGVTVQDPPVHIVDPREHVFVHAITSECVML 827
            +P     +SG +  +    S      A   V  +  P + V   + + V   +   V L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ--VRL 123

Query: 828 ACEVDREDAPV-RWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
              V     PV ++Y+DG E++ S    +  EG    L++    P D G +   A +   
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183

Query: 887 YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL 922
             T T        +   G+  V A + + +V T ++
Sbjct: 184 RATSTAE------LLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 5/122 (4%)

Query: 219   QAGALLQVHQPPESPPADPDEAPAPVVEP---LKCAPKTFW-VNEGKHAKFRCYVMGKPE 274
             +A A   V+  P S P+DP    A  V P   L  A K+   V  G +      V GKP 
Sbjct: 19265 RAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPM 19324

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P + W  +G  L P     M   R+    L++     KD G Y   A NS+G   + ++L
Sbjct: 19325 PTVSWKKDGTLLKPAEGIKMAMQRN-LCTLELFSVNRKDSGDYTITAENSSGSKSATIKL 19383

Query: 335   HV 336
              V
Sbjct: 19384 KV 19385



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 23/87 (26%), Positives = 34/87 (39%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + + V +G   EL   + G PPP   W   G +L  SER++         L +      D
Sbjct: 29746 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRD 29805

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPP 105
              G Y    +N  G       V +L+ P
Sbjct: 29806 TGEYTLELKNVTGTTSETIKVIILDKP 29832



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 48/225 (21%), Positives = 86/225 (38%), Gaps = 25/225 (11%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G    L+C+  G P P + W + G    E+  S  + +         G +  L ++    
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGK---ELIQSRKYKMS------SDGRTHTLTVMTEEQ 30597

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGK 261
              D GVY C A N  G  +  + L +   P+  P            PLK   + ++   G 
Sbjct: 30598 EDEGVYTCIATNEVGEVETSSKLLLQATPQFHPG----------YPLK---EKYYGAVGS 30644

Query: 262   HAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR-GLYVCA 320
               +     +G+P P + W + G+ LL +   +   + +    L +   Q K   G Y   
Sbjct: 30645 TLRLHVMYIGRPVPAMTW-FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ 30703

Query: 321   ARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
               N  G   + + + +++   + T P+  +E      AV+  K P
Sbjct: 30704 LSNVFGTVDAILDVEIQDKPDKPTGPIV-IEALLKNSAVISWKPP 30747



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 2/99 (2%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             +G +G PP     P  + +  G    + C   GEP P V W  GG+++ + E+  F  + 
Sbjct: 33322 AGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIEN 33381

Query: 65    AEH--GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +    L++      D G+Y     N  G   A   + +
Sbjct: 33382 TDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 25/83 (30%), Positives = 35/83 (42%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + SG    +K +V G P P V W K G ++     +          L +  A     GVY
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 28029

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+NA+G A A   V V + P
Sbjct: 28030 TVEAKNASGSAKAEIKVKVQDTP 28052



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 119/577 (20%), Positives = 207/577 (35%), Gaps = 118/577 (20%)

Query: 1111 QVRWYKDGLEVEASDALQLG-AEGPTRTLTLPHAQPEDAGEYVC---ETRHEAITFNVIL 1166
            ++ WYKDG  ++  +  Q+   +    +L +P   PED G Y       +  AI    + 
Sbjct: 1321 KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY 1380

Query: 1167 AEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGP 1226
             EP     A      P  +   EPV      SR  +    S +  P++           P
Sbjct: 1381 VEPAAPLGA------PTYIPTLEPV------SRIRSLSPRSVSRSPIRMSPA----RMSP 1424

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGD 1286
             R+       PA         G        S   ++ +P V V+ P + +     T   D
Sbjct: 1425 ARM------SPARMSPARMSPGRRLEETDESQLERLYKP-VFVLKPVSFKCLEGQTARFD 1477

Query: 1287 LELVVHLSGPGGPVRWYKDGERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAP 1344
            L++V     P     W+ DG+++ +    +V +++ G + ++ V    S D+GE+   A 
Sbjct: 1478 LKVV---GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPS-DSGEWTVVAQ 1533

Query: 1345 QDSRIFLVSV-------EEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
              +    +SV       E  +    V +L  + + EG     +   +  P+ D+ WL+N 
Sbjct: 1534 NRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS 1593

Query: 1397 AVVTPG--PQVEMAQNGSSRILTLRGCQLGDA----GTVTLRAGSTATSARLHVR----- 1445
             ++ P   P++ +        L +      D+     T   +AG   T  +++V      
Sbjct: 1594 DIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAE 1653

Query: 1446 ---ETELLFLR---RLQDVRAEE--------GQDVCLE--------------------VE 1471
               E +L+  R   R +++ A E        GQ+   E                    + 
Sbjct: 1654 PEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1713

Query: 1472 TGRVGAAG-------------AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQG 1518
              R G A               V W+  G+PL   +RL M  +     L        D G
Sbjct: 1714 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSG 1773

Query: 1519 TYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE----LSQEG-VT 1569
               C + +    D T A L V+  +  V    E+  + EG     ++E    ++ EG +T
Sbjct: 1774 IITCRATNKYGTDHTSATLIVKDEKSLV----EESQLPEGRKGLQRIEELERMAHEGALT 1829

Query: 1570 G------EWARGGVQLYPGPKCHIHSDGHRHRLVLNG 1600
            G      E  +  + LYP P   +  +  R R  + G
Sbjct: 1830 GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTG 1866



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 79/341 (23%), Positives = 128/341 (37%), Gaps = 51/341 (14%)

Query: 105   PASDPELQPAERPLPSPG----------SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGL 154
             P+SDP    A RP+  PG          S E A +  T P S         V+ C+  G 
Sbjct: 17790 PSSDPI--KACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG- 17846

Query: 155   PEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
                T  W +  +  DE+     F + PG  E   G     RI AA +   G         
Sbjct: 17847 ---TAQWNR--INKDELIRQCAFRV-PGLIE---GNEYRFRIKAANIVGEG-------EP 17890

Query: 215   HGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                A++     +  PPE             VE          V  G+  +    V G+PE
Sbjct: 17891 RELAESVIAKDILHPPE-------------VELDVTCRDVITVRVGQTIRILARVKGRPE 17937

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P+I W  EG+ L+ ++R  + +D      L++      D G Y+ +A+NS+G    +  +
Sbjct: 17938 PDITWTKEGKVLVREKRVDLIQDLP-RVELQIKEAVRADHGKYIISAKNSSGHAQGSAIV 17996

Query: 335   HVKEPRLRFTRPLQDVE----GREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
             +V    L    P Q+++     +E+     E  + N       F  + R    + +  + 
Sbjct: 17997 NV----LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVA 18052

Query: 391   EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
                 +RLI   L A+++  +      +V     +  K PIL
Sbjct: 18053 SDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPIL 18093



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 25/100 (25%), Positives = 41/100 (41%), Gaps = 1/100 (1%)

Query: 239   EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDR 298
             EA   ++ P    P+   +  GK  +   +V GKP P  +W  +G   +     L     
Sbjct: 18892 EAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKA 18950

Query: 299   DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
             D   +L +     KD G Y   A NS+G     +++ V +
Sbjct: 18951 DSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMD 18990



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 1/85 (1%)

Query: 458   EGRWSRD-GEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             E +W+RD GE L      S+     L++  V R D+G+   ++ NS  +    V      
Sbjct: 21891 EVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLD 21950

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPP 541
              PGPP   ++ +  K +V LTW PP
Sbjct: 21951 TPGPPQDLKVKEVTKTSVTLTWDPP 21975



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 34/119 (28%), Positives = 47/119 (39%), Gaps = 11/119 (9%)

Query: 231   ESPPADPDEAPAPVVEP-------LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             E   +DP     PV+         LK    T+ +  G+  K    V+G+P P I W  +G
Sbjct: 24290 EKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDG 24349

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG---QTLSAVQLHVKEP 339
              P L    R+   +     VL +      D G Y   A NSAG   + LS + L    P
Sbjct: 24350 EP-LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGP 24407



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 23/91 (25%), Positives = 42/91 (46%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             L +   V+  +G   +L+  + G+P P + W K  ++L  +  +          +L+  A
Sbjct: 26876 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDA 26935

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                ++G Y  + RNA G A A   V +L+ P
Sbjct: 26936 DRLNSGCYELKLRNAMGSASATIRVQILDKP 26966



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 21/182 (11%)

Query: 1178 TTPSPLCVAPGEPVVL------SCELSRAGAPVV---WSHNGRPVQEGE--GLELHAEGP 1226
            TT +P    P + VV+      + E   +G PV    W  +G+ +      G+++     
Sbjct: 2    TTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDG 61

Query: 1227 RRVLCIQAAGPAHAGLYTCQ----SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRST 1282
            R  L I A   A++G Y+ +    SG A     L    + A PP  V   ++   R    
Sbjct: 62   RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA-PPNFVQRLQSMTVR---- 116

Query: 1283 PGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
             G  + L V ++G P   V++Y+DG  + S    Q+ Q G    L +  A   D+G Y  
Sbjct: 117  QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176

Query: 1342 DA 1343
            +A
Sbjct: 177  NA 178



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 7/101 (6%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQL-AASERLSFPADGAEHGLLLTAALPTDAGV 81
             V +G    L+  + G+P P VVW K G++L   + R+   +   +  L++   + TD G 
Sbjct: 24719 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 24778

Query: 82    YVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             Y+ +  N  G       V VL+ P       P E PL   G
Sbjct: 24779 YILKLSNVGGTKSIPITVKVLDRPG------PPEGPLKVTG 24813



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 68/300 (22%), Positives = 118/300 (39%), Gaps = 39/300 (13%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAG 573
             SP  PP   +     + T+ L W PP     +  + Y +E+++ G+E W++C F+     
Sbjct: 27853 SPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSEC 27911

Query: 574   AVEVPGDCVPSEGD-YRFRIC------TVSGHGRSPHVVFHGSAHLVPTARLVAGLED-V 625
                V G    S GD Y FRI       T+S   +S  ++     ++ P         D +
Sbjct: 27912 QYTVTG---LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGL 27968

Query: 626   QVYDGEDAVFSLDLSTIIQG------TWFLNGEEL-KSNEPEGQVEPGALRYRIEQKGLQ 678
              +  GE    SL +  ++QG      TWF +G E+ K    E     G+    +      
Sbjct: 27969 IIKSGE----SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRD 28024

Query: 679   HRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTC 738
             HR +        SG+         +    + +Q++P  ++ P   +  T  T E++ L  
Sbjct: 28025 HRGVYTVEAKNASGS--------AKAEIKVKVQDTPGKVVGP---IRFTNITGEKMTLWW 28073

Query: 739   ELSRVD--FPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
             +    D   P T Y   +K E S L    ++ +         K+ +  E++ R   V+ F
Sbjct: 28074 DAPLNDGCAPITHYII-EKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKF 28132



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 38/252 (15%)

Query: 373   WFREDQRLLPCRKY--EQIEEGTVRRLIIHRLKADDDG-------IYLCEMRGRVRTVAN 423
             W R  ++++  R+Y  ++I EG   +L +  + A  +G       + + E +       +
Sbjct: 15048 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELD 15107

Query: 424   VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGEELPV--ICQSS 475
             V+VKG I         ++ G+        + A V GR      W+++  EL    +   +
Sbjct: 15108 VSVKGGI--------QIMAGKTL-----RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDN 15154

Query: 476   SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
              G    L++    R+D G    +  NS  +     +      PGP +  +    ++   L
Sbjct: 15155 VGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCL 15214

Query: 536   LTWKPPEP---APETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
             L W  PE    +  T FI  +ER++     W Q    E++   ++ G  +    +Y+FR+
Sbjct: 15215 LNWSDPEDDGGSEITGFI--IERKDAKMHTWRQPIETERS-KCDITG--LLEGQEYKFRV 15269

Query: 593   CTVSGHGRSPHV 604
                +  G  P V
Sbjct: 15270 IAKNKFGCGPPV 15281



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 34/112 (30%), Positives = 46/112 (41%), Gaps = 11/112 (9%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    L   V G+P P V W+K G  L  +E +          L L +    D+G Y
Sbjct: 19307 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDY 19366

Query: 83    VCRARNAAGEAYAAAAVTVLE---PPA--------SDPELQPAERPLPSPGS 123
                A N++G   A   + VL+   PPA        SD  +   E PL   GS
Sbjct: 19367 TITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGS 19418



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 22/86 (25%), Positives = 42/86 (48%), Gaps = 1/86 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP   +++   +++V L+W  P     +P I Y +E +   S++W++C   +     
Sbjct: 19588 PPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKT 19647

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
                   +  +  Y+FR+  V+  G S
Sbjct: 19648 RFEVTGLMEDTQYQFRVYAVNKIGYS 19673



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 108/551 (19%), Positives = 196/551 (35%), Gaps = 81/551 (14%)

Query: 418   VRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ--- 473
             V  +A   V  P  K L     VL GE+  + V  +        W +D   L    +   
Sbjct: 22137 VPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNA 22196

Query: 474   SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPI-LAEMFKGHKN 532
              S+ +   L +    RED G     L NS    +  +  +    PGPP    +M +   +
Sbjct: 22197 ESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTAD 22256

Query: 533   TVLLTWKPPE-PAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
             ++ L+W PP+     +   Y +E+++  +  W Q  S   A    +    + +  +Y+FR
Sbjct: 22257 SITLSWGPPKYDGGSSINNYIVEKRDTSTTTW-QIVSATVA-RTTIKACRLKTGCEYQFR 22314

Query: 592   ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
             I   + +G+S ++    +    P               G      + LS+        + 
Sbjct: 22315 IAAENRYGKSTYLNSEPTVAQYPFK-----------VPGPPGTPVVTLSS-------RDS 22356

Query: 652   EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
              E++ NEP        + Y +E+K  +   IL    ++       F   G+++      +
Sbjct: 22357 MEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFR 22414

Query: 712   ESPVHI--LSPQDRVSLTFTT---------SERVVLTCELSRVDFPATWYKDGQK----- 755
              S  +I  +    +VS  +            E +++T     + +    Y  G K     
Sbjct: 22415 VSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYI 22474

Query: 756   VEESELLVVKMDGR---------------------KHRLILPEAKVQDSGEFECRTEGVS 794
             VE+ EL     +GR                      HR          +G F   +E   
Sbjct: 22475 VEKKEL----PEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTG 22530

Query: 795   AFFGVTVQDPPVHIVDP--REHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESD 851
             A       DPP   +DP  ++ + VHA   E   +  ++  +  P ++W K  QE+  + 
Sbjct: 22531 AITARDEVDPPRISMDPKYKDTIVVHA--GESFKVDADIYGKPIPTIQWIKGDQELSNTA 22588

Query: 852   FVVLENEGPHRRLVLPATQPSDGGEF----QCVAGDECAYFTVTITDVSSWIVYPSGKVY 907
              + +++      L +      D G +    + VAG+      V + D       P G V 
Sbjct: 22589 RLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG---PPEGPVV 22645

Query: 908   VAAVRLERVVL 918
             ++ V  E+  L
Sbjct: 22646 ISGVTAEKCTL 22656



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 94/441 (21%), Positives = 167/441 (37%), Gaps = 67/441 (15%)

Query: 461   WSRDGEELP--VICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP 518
             WS+ G +L    I  ++  +   L++  V R DAG+ T    N        V    +  P
Sbjct: 29480 WSKQGIDLASRAIIDTTESYS-LLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 29538

Query: 519   GPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEV 577
             GP    ++ +  +++V +TW+ P      P   Y +E++E     +    +        +
Sbjct: 29539 GPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRI 29598

Query: 578   PGDCVPSEGD-YRFRICTVSGHG-----RSPHVVFHGSAHLVP--------TARLVAGLE 623
              G     EG  Y FR+   + +G      +   V      LVP        T   V    
Sbjct: 29599 SGLV---EGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAW 29655

Query: 624   DVQVYDGEDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQ--KGLQH 679
             +  +YDG   +    L     GT  W               ++P  L + +    +G Q+
Sbjct: 29656 EKPLYDGGSRLTGYVLEACKAGTERWM----------KVVTLKPTVLEHTVTSLNEGEQY 29705

Query: 680   RLILHAVKHQDSGALVGFSCPGVQDSAALTIQES---PVHILSPQDRVSLTFTTSERVVL 736
                + A   +      G S P  +   A+T+Q+    P   LS   + ++       V L
Sbjct: 29706 LFRIRAQNEK------GVSEPR-ETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 29758

Query: 737   TCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA 795
                ++    PA +W+  G K+ ESE + V+   +  +L + E  ++D+GE+    + V+ 
Sbjct: 29759 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVT- 29817

Query: 796   FFGVTVQDPPVHIVD----PREHVFVHAITSECVMLACEVDRED--APVRWYKDGQEVEE 849
               G T +   V I+D    P   + +  I +  + ++ E    D  AP+  Y        
Sbjct: 29818 --GTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGY-------- 29867

Query: 850   SDFVVLENEGPHRRLVLPATQ 870
                 V+E    HR   LP ++
Sbjct: 29868 ----VVEQRDAHRPGWLPVSE 29884



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/219 (24%), Positives = 82/219 (37%), Gaps = 32/219 (14%)

Query: 127   APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
             AP F    R+  V   +   L C+  G P+P + W + G  +  + D   +     R ++
Sbjct: 30927 APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEI--IADGLKY-----RIQE 30979

Query: 187   GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
               G    L I +    D+ VY   A N  G     A L+V            E PA +  
Sbjct: 30980 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------------EVPAKI-- 31025

Query: 247   PLKCAPKTFWVNEGKHA------KFRCYVMGKPEPEIEWHWEGRPLLPDRRRL-MYRDRD 299
                  PKT       HA        +    GKP+P I W  +G+ L+ +     +   R 
Sbjct: 31026 ---HLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRS 31081

Query: 300   GGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
                ++     + KD G YV  A+N  G     V+L V +
Sbjct: 31082 FTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 31120



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 58/260 (22%), Positives = 101/260 (38%), Gaps = 55/260 (21%)

Query: 259   EGKHAKFRCYVMGKPEP-EIEWHWEGRPLL-PDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             EG H K+ C +    +  ++ W++  R L   ++  + Y D  G  +L V      D G 
Sbjct: 31581 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED--GVAILYVKDITKLDDGT 31638

Query: 317   YVCAARNSAGQTLSAVQLHVKEPRLRF----TRPLQDVEGREHGIAVLECKVPNSRIP-- 370
             Y C   N  G+  S  +L VK  R  +     R ++ ++ R   + +LE + P   +P  
Sbjct: 31639 YRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLE-RPPEFTLPLY 31697

Query: 371   -----------------------TAWFREDQRLLP---CRKYEQIEEGTVRRLIIHRLKA 404
                                      W++  Q++ P    +KY    +  + +L I+ +  
Sbjct: 31698 NKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTT 31757

Query: 405   DDDGIYLCEMR---GRVRTVANVTVK----------GPILKRLPRKLDVLEGENAVLLVE 451
             DDD  Y    R   G     A +TV            P+ KRL    +  EG++  +  E
Sbjct: 31758 DDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQS--VCFE 31815

Query: 452   TLEAGVEG---RWSRDGEEL 468
                +G+     +W +DG+ L
Sbjct: 31816 IRVSGIPPPTLKWEKDGQPL 31835



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 45/169 (26%), Positives = 63/169 (37%), Gaps = 38/169 (22%)

Query: 85    RARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAE 144
             RA NAAG         + EP  + P  +  + P+ +P       V L    S  V RG E
Sbjct: 14655 RAENAAG---------ISEPSRATPPTKAVD-PIDAP------KVILR--TSLEVKRGDE 14696

Query: 145   VVLTCRAGGLPEPTLYWEKDGMAL-----------------DEVWDSSHFAL---QPGRA 184
             + L     G P PT+ W KD   +                  EV +   F L   Q    
Sbjct: 14697 IALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSI 14756

Query: 185   EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
             ++       LR+  +  PD G+Y+    N HG A+A   + V   P  P
Sbjct: 14757 DNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPP 14805



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 6/145 (4%)

Query: 914   ERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC-- 970
             E   L+C++  RP  +++W + G+E+++S    +  +     L +   + ED G Y C  
Sbjct: 30548 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 30607

Query: 971   --EIDD-ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGL 1027
               E+ + E++S  +    P     YP  E    AV     + +  + R    + W+    
Sbjct: 30608 TNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK 30667

Query: 1028  EVEESEALVLERDGPRCRLVLPAAQ 1052
              ++ SE + +E       LV+   Q
Sbjct: 30668 LLQNSENITIENTEHYTHLVMKNVQ 30692



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 44/168 (26%), Positives = 71/168 (42%), Gaps = 14/168 (8%)

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTG-EWARGG----VQLYPGPKCHIHSDGHRHRLVL 1598
            +PL+ V + EG +ATF+  +S   V    W R G        PG +    SDG R +L +
Sbjct: 10   QPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDG-RAKLTI 67

Query: 1599 NGLGLADSGCVSFTADS----LRCAARLIVR--EVPVTIVRGPHDLEVTEGDTATFECEL 1652
              +  A+SG  S  A +        A L+V+    P   V+    + V +G     +  +
Sbjct: 68   PAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRV 127

Query: 1653 SQALADVT-WEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYS 1699
            +     V  + +DG  +  S   ++   G    L +    P D+GTYS
Sbjct: 128  TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 61/249 (24%), Positives = 93/249 (37%), Gaps = 58/249 (23%)

Query: 1614 DSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSP 1672
            ++ R  A + +   P T+V G  ++ V EG++ T EC +S      VTW ++   +  S 
Sbjct: 928  ETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI 987

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTAR-----AGPVRLTVRERTVAV-- 1721
              ++        L +R     D+G ++C+     GT       A  V     + T AV  
Sbjct: 988  DFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047

Query: 1722 ---LSELRSVSAR----------------------------------EGDGATFECTV-S 1743
                 E R V +R                                  EG    F C V  
Sbjct: 1048 KFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGG 1107

Query: 1744 EVETTGRWELGGRPLRPGARVRI---RQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
              +    W+  G PL  G R ++   +Q G+   LV+S   A+DAGE    VR + G   
Sbjct: 1108 NPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECK-LVISMTFADDAGEYTIVVRNKHGETS 1166

Query: 1797 SLALLEVEA 1805
            + A L  EA
Sbjct: 1167 ASASLLEEA 1175



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 35/144 (24%), Positives = 63/144 (43%), Gaps = 7/144 (4%)

Query: 232   SPPADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
             S P  P ++  P+  P  K   +   V    +A   C V G P+P ++W+ +G+ ++ D 
Sbjct: 30914 SEPITP-KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 30972

Query: 291   RRLMYRDRDGGF-VLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP-RLRFTRPLQ 348
              +   ++  GG+  L +      D  +Y   A N  G       L V+ P ++   + L+
Sbjct: 30973 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLE 31032

Query: 349   DVEGREHGI--AVLECKVPNSRIP 370
              + G  H +   V+  K+P S  P
Sbjct: 31033 GM-GAVHALRGEVVSIKIPFSGKP 31055



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 2/97 (2%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R   +  G    L  ++ G P P V W+K  +      R+     G++  L +  A   D
Sbjct: 17226 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK--LEIRNAAHED 17283

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
              G+Y     N AG    +  V VL+ P    +L+ +E
Sbjct: 17284 GGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSE 17320



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 75/311 (24%), Positives = 119/311 (38%), Gaps = 33/311 (10%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP + E+ K  KN++ + W  P     +    Y LE+++  S  W +    E      
Sbjct: 27066 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLK-ETIRDTR 27124

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH---VVFHGSAHLV----PTARL---------VA 620
                  +    DY++R+C V+  G+ P      F+ +A  +    P A++         + 
Sbjct: 27125 QKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT 27184

Query: 621   GLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHR 680
                   VYDG  AV    +  I QG      EE  +   +G+V          + G+ + 
Sbjct: 27185 LGWSKPVYDGGSAVTGY-VVEIRQG----EEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 27239

Query: 681   LILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERV-VLTCE 739
               + AV     G  +  + P VQ   A  I E+P   L    R S+     E V VL   
Sbjct: 27240 FRVSAVNCAGQGEPIEMNEP-VQ---AKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPF 27295

Query: 740   LSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE-GV----S 794
               R     TW KD + +       ++       L +P+    D+G++    E GV    S
Sbjct: 27296 KGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKS 27355

Query: 795   AFFGVTVQDPP 805
             +   V V D P
Sbjct: 27356 STVSVKVLDTP 27366



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 5/103 (4%)

Query: 492   AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
             A E  + +G     + +  K  +  PPGPP   E     K+ V LTW  P+    +P   
Sbjct: 13858 AAENMYGVGEPVQASPITAK-YQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITG 13916

Query: 551   YRLERQEVGSEDWIQCFSIE-KAGAVEVPGDCVPSEGDYRFRI 592
             Y +ER +  ++ W++C  +  K     V G  + ++  YRFR+
Sbjct: 13917 YWVERLDPDTDKWVRCNKMPVKDTTYRVKG--LTNKKKYRFRV 13957



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 34/164 (20%), Positives = 71/164 (43%), Gaps = 17/164 (10%)

Query: 823   ECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA 881
             E   L+C++     P ++WY+ G+E+ +S    + ++G    L +   +  D G + C+A
Sbjct: 30548 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 30607

Query: 882   GDECAYFTVTITDVSSWIV----------YPSGKVYVAAVRLERVVLTCELCRPWAEVRW 931
              +E     V   + SS ++          YP  + Y  AV     +    + RP   + W
Sbjct: 30608 TNE-----VGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW 30662

Query: 932   TKDGEEVVESPALLLQKEDTVRRLVLPAVQLE-DSGEYLCEIDD 974
                 + +  S  + ++  +    LV+  VQ +  +G+Y  ++ +
Sbjct: 30663 FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSN 30706



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
             SPPGPPI   +      T+ L W+PP        + Y +++Q VG+ +W +C   EK   
Sbjct: 15001 SPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC--TEKMIK 15057

Query: 575   VEVPGDCVPSEG-DYRFRICTVSGHGRSP 602
             V         EG DY+ R+  V+  G  P
Sbjct: 15058 VRQYTVKEIREGADYKLRVSAVNAAGEGP 15086



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 32/91 (35%), Positives = 43/91 (47%), Gaps = 7/91 (7%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPE---PAPETPFIYR-LERQEVGS--EDWIQCFSIE 570
             PP PPI  ++    KNTV L+WKPP+    +P T +I   L     G+  E W QC   +
Sbjct: 16011 PPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRD 16070

Query: 571   KAGAVEVPGDCVPSEGDYRFRICTVSGHGRS 601
                      D V   G+Y FR+  V+  G S
Sbjct: 16071 VEELQFTVEDLVEG-GEYEFRVKAVNAAGVS 16100



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 43/144 (29%), Positives = 52/144 (36%), Gaps = 17/144 (11%)

Query: 93    AYAAAAVTVLEPPA-SDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRA 151
             A A  AV +  P   SDP    AE   P           LT      V  G  V L    
Sbjct: 19266 AIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLT------VKAGTNVCLDATV 19319

Query: 152   GGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHA 211
              G P PT+ W+KDG  L    +    A+Q             L + +    DSG Y   A
Sbjct: 19320 FGKPMPTVSWKKDGTLLKPA-EGIKMAMQRNLC--------TLELFSVNRKDSGDYTITA 19370

Query: 212   RNAHGHAQAGALLQVHQPPESPPA 235
              N+ G   A   L+V   P  PPA
Sbjct: 19371 ENSSGSKSATIKLKVLDKP-GPPA 19393



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 8/109 (7%)

Query: 235   ADPDEAPAPVVEPLKCAP-------KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
             +DP +   PV+      P        TF V  G+  K     +G+P P + WH +  P L
Sbjct: 22130 SDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVP-L 22188

Query: 288   PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
                 R+     +   +L +     +D G YV    NSAG+ +  + + V
Sbjct: 22189 KQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 22237



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 3/100 (3%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   + V +G   ++   + G P PV+ W K G ++    R    +      L +   
Sbjct: 25793 VKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDC 25852

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLE---PPASDPEL 111
             +  D G YV   +N AG    A    VL+   PPA   E+
Sbjct: 25853 IRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEI 25892



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 5/84 (5%)

Query: 42   VVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRAR-NAAGEAYAAAAVT 100
            +V W KG  +L  S++ +F  DG  H + +    P D GVY   AR    GEA + A + 
Sbjct: 8863 IVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELY 8922

Query: 101  V----LEPPASDPELQPAERPLPS 120
            +    ++     P++  +  P+P+
Sbjct: 8923 LTTKEIKLELKPPDIPDSRVPIPT 8946



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 11/112 (9%)

Query: 460   RWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             +W+ DG E+         +      L +    R D GE   ++ N+  +  + V      
Sbjct: 17543 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 17602

Query: 517   PPGPPI----LAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
              PGPP     + ++   H   + ++W+PP+    +P I Y +E+Q+   + W
Sbjct: 17603 VPGPPTGPINILDVTPEH---MTISWQPPKDDGGSPVINYIVEKQDTRKDTW 17651



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 3/122 (2%)

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW 538
             M  LV+P  TR+D+G+ + +L N      + V       PGP    ++    K +  ++W
Sbjct: 18660 MAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSW 18719

Query: 539   KPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
              PPE    +    Y +E++E   + W       K  +  V  + VP   +Y FR+  V+ 
Sbjct: 18720 APPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVT-NLVPG-NEYYFRVTAVNE 18777

Query: 598   HG 599
             +G
Sbjct: 18778 YG 18779



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 108/521 (20%), Positives = 190/521 (36%), Gaps = 75/521 (14%)

Query: 475   SSGHMHALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKGH 530
             SS     L++    + DAG+ T +L    G    T  ++V      P GP    E+    
Sbjct: 20033 SSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTA-- 20090

Query: 531   KNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DY 588
                + L W PP+    +    Y LE+++  +  W+ C S  +     V       EG +Y
Sbjct: 20091 -EAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTR---LHEGMEY 20146

Query: 589   RFRICTVS----GHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
              FR+   +    G G     +       VP A     + DV+ +D     ++    T   
Sbjct: 20147 TFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVR-HDSVSLTWTDPKKT--- 20202

Query: 645   GTWFLNGEELKSNEPEGQVEPGALRYRIEQK---------GLQHRLILHAVKHQDSGALV 695
             G   + G  L+  E    +   A +  I  +         GL++   + A+       L 
Sbjct: 20203 GGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAIN------LA 20256

Query: 696   GFSCPGVQDSAALTIQE-----SPVHILSPQDRVSLTFTTSE----RVVLTCELSRVDFP 746
             G   P +     + +        P  I   ++ V+L +T  +      +    + + D P
Sbjct: 20257 GVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLP 20316

Query: 747   A-TWYKDGQ-KVEESELLVVKM-DGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
             + +W K     V E    V  + +G K+   +  AK   +G     +E           +
Sbjct: 20317 SKSWMKANHVNVPECAFTVTDLVEGGKYEFRI-RAK-NTAGAISAPSESTETIICKDEYE 20374

Query: 804   PPVHIVDPREHVFVHAITSECVML-ACEVDREDAPVR-WYKDGQEVEESDFVVLENEGPH 861
              P  ++DP     +     + ++L A  +  +  P   W K G+++  SD   + +    
Sbjct: 20375 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 20434

Query: 862   RRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVV 917
               L +      D GE+   A    G +  +  VT+ DV      P G V ++ V  E+  
Sbjct: 20435 SMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPG----PPGPVEISNVSAEKAT 20490

Query: 918   LTCELCRPWAEVRWT---KDGEEVVESPALLLQKEDTVRRL 955
             LT           WT   +DG   ++S   +L+K +T R L
Sbjct: 20491 LT-----------WTPPLEDGGSPIKS--YILEKRETSRLL 20518



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 43/170 (25%), Positives = 66/170 (38%), Gaps = 14/170 (8%)

Query: 253   KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP--DRRRLMYRDRDGGFVLKVLYCQ 310
             KT +V  G++ +F   +   PEP + W+  G+ + P  + ++  +    G + L +    
Sbjct: 31699 KTAYV--GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVT 31756

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHV--------KEPRLRFTRPLQDVEGREHGIAVLEC 362
               D   Y   ARN  G+     +L V           R  F R L + E +E      E 
Sbjct: 31757 TDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEI 31816

Query: 363   KVPNSRIPT-AWFREDQRLLPCRKYEQIEEG-TVRRLIIHRLKADDDGIY 410
             +V     PT  W ++ Q L      E I EG     L I     +D G Y
Sbjct: 31817 RVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 31866



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 12/128 (9%)

Query: 119   PSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAG----------GLPEPTLYWEKDGMAL 168
             PS  +GE     +      ++  GA+  L C+AG          G P P   WE DG A 
Sbjct: 15792 PSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAK 15851

Query: 169   DEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ 228
               + D  H   +  + E    +S+ + I   +   +G Y   A+N  G   A   ++V  
Sbjct: 15852 KAMKDGVHDIPEDAQLETAENSSVII-IPECKRSHTGKYSITAKNKAGQKTANCRVKVMD 15910

Query: 229   PPESPPAD 236
              P  PP D
Sbjct: 15911 VP-GPPKD 15917



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 27/131 (20%)

Query: 124   GEGAPVFLTGP----------------RSQWVLR-GAEVVLTCRAGGLPEPTLYWEKDGM 166
             G+G P F T P                R +  +R G    LT R  G P+P + W KD  
Sbjct: 16798 GQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEA 16857

Query: 167   ALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
              + E  D +H    P        A+LAL  + A+  DSG Y     N+ G  +    + V
Sbjct: 16858 DVLED-DRTHIKTTP--------ATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNV 16908

Query: 227   HQPPESPPADP 237
                P  PP  P
Sbjct: 16909 VDRP-GPPVGP 16918



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 2/86 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAGAV 575
             P PP+  E      N+V LTW+PP     +  + Y +E Q+VG E+W +   + E     
Sbjct: 17113 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 17172

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             +     +     Y+FR+  V+  G S
Sbjct: 17173 KYKVTGLRDGQTYKFRVLAVNAAGES 17198



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 43/154 (27%), Positives = 67/154 (43%), Gaps = 19/154 (12%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP         K  V L W  P+    +P   Y +E QE G++DWI+  ++     V
Sbjct: 17409 PPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECV 17468

Query: 576   EVPGDCVPSEGDYRFRIC--TVSGHGRSPHVV-FHGSAHLVPTARLVAGLEDVQVYDG-- 630
              V G  +     YRFR+    + G G     +       LVP +  +    DV++ +G  
Sbjct: 17469 -VTG--LQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVEL----DVKLIEGLV 17521

Query: 631   EDAVFSLDLSTIIQGT------WFLNGEELKSNE 658
               A  ++    II+G       W  +G E+K++E
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE 17555



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 4/113 (3%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILA-EMFKGHKNTVLLTWK- 539
             L++  VTR+D+G  + +  NS  T   ++K V    PGPP    ++     +   L+W  
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHI 19015

Query: 540   PPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
             P E        Y +E+ +V   DW+   +     +  V G  +P + +Y FR+
Sbjct: 19016 PLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRV-GKLIPGQ-EYIFRV 19066



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 42/163 (25%), Positives = 63/163 (38%), Gaps = 22/163 (13%)

Query: 453   LEAGVEGR------WSRDGEELPVICQ----SSSGHMHALVLPGVTREDAGEVTFSLGNS 502
             LEA + G+      WS+DG+EL          S+     LV+    R D G+    L N 
Sbjct: 24727 LEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV 24786

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKPP-EPAPETPFIYRLERQEVGS 560
               T  + +       PGPP       G       L W PP +        Y +E++E   
Sbjct: 24787 GGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSR 24846

Query: 561   EDWIQCFSIEKAGAVEV----PGDCVPSEGDYRFRICTVSGHG 599
               W Q  +  +A   +V    PG+      +Y FR+  V+ +G
Sbjct: 24847 LSWTQVSTEVQALNYKVTKLLPGN------EYIFRVMAVNKYG 24883



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 39/171 (22%), Positives = 71/171 (41%), Gaps = 12/171 (7%)

Query: 1005  ECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC-- 1061
             E   L C++     P ++WY+ G E+ +S    +  DG    L +   + ED G + C  
Sbjct: 30548 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 30607

Query: 1062  --DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQV---RWYK 1116
               + G+      + + A P+   HP     + ++GA G   LR  V   G  V    W+ 
Sbjct: 30608 TNEVGEVETSSKLLLQATPQ--FHPGYPLKEKYYGAVGST-LRLHVMYIGRPVPAMTWFH 30664

Query: 1117  DGLEVEASDALQLGAEGPTRTLTLPHAQPE-DAGEYVCETRHEAITFNVIL 1166
                 ++ S+ + +        L + + Q +  AG+Y  +  +   T + IL
Sbjct: 30665 GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAIL 30715



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 6/112 (5%)

Query: 231  ESPPADPDEAPAPVVEP-----LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
            E+   +    PAPV  P     L    K   V EG+     C++ G P P + W+ E   
Sbjct: 923  EAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 982

Query: 286  LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             +          + G   L +    A+D G + C+A N AG   ++  L V+
Sbjct: 983  -IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 30/120 (25%), Positives = 52/120 (43%), Gaps = 4/120 (3%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKP 540
             LV+P   R D G  T +  N+  T    ++      PGPP+    F+    + + L+W P
Sbjct: 16181 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFP 16240

Query: 541   PEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
             P+    +    Y +E++E   + W+   S  K     +P   +    +Y FRI   + +G
Sbjct: 16241 PKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPK--LLEGHEYVFRIMAQNKYG 16298



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 3/91 (3%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFS 568
             C    PPGPPI  ++    + T  L W  P     +P + Y +E Q+ G+  W  I    
Sbjct: 17798 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 17857

Query: 569   IEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
             + +  A  VPG    +E  +R +   + G G
Sbjct: 17858 LIRQCAFRVPGLIEGNEYRFRIKAANIVGEG 17888



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 71/336 (21%), Positives = 122/336 (36%), Gaps = 30/336 (8%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P  P  A + K +K+ + + W  P+    +P I Y +ER+E  S  W++  +     + E
Sbjct: 19092 PSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKA-NDTLVRSTE 19150

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSP------------HVVFHGSAHLVPTARLVAGLED 624
              P   +    +Y FRI  ++  G SP             V   G   ++   +    L  
Sbjct: 19151 YPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIW 19210

Query: 625   VQ-VYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI 682
              +  +DG   +    +    + G  ++         P+ +     L    E+   Q R I
Sbjct: 19211 ARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLE---EKAQYQFRAI 19267

Query: 683   LHAVKHQDSGALVGFSCPG-VQDSAALTIQESPVHI-LSPQDRVSLTFTTSERVVLTCEL 740
                         V  S P    D   +  +  P  I LS   +  LT      V L   +
Sbjct: 19268 ARTA--------VNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 19319

Query: 741   SRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGV 799
                  P  +W KDG  ++ +E + + M      L L     +DSG++    E  S     
Sbjct: 19320 FGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSA 19379

Query: 800   TVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
             T++   +    P   V ++ + S+  ML+ E   ED
Sbjct: 19380 TIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLED 19415



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 22/71 (30%), Positives = 30/71 (42%)

Query: 35    VLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAY 94
             +LG+P P   W K G+ +  S+     +      L +  A   DAG Y   A N  G   
Sbjct: 20403 ILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKV 20462

Query: 95    AAAAVTVLEPP 105
                 VTVL+ P
Sbjct: 20463 EHVKVTVLDVP 20473



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query: 481   ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKP 540
             +L +    R D+G+ T ++ N  +   L +       PGPP    +    K + +L+W  
Sbjct: 26241 SLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDV 26300

Query: 541   PEPAPETPF-IYRLERQEVGSEDWI 564
             PE     P   Y +E++E   + W+
Sbjct: 26301 PENDGGAPVKNYHIEKREASKKAWV 26325



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 27/114 (23%), Positives = 51/114 (44%), Gaps = 7/114 (6%)

Query: 238   DEAPAPVVEPLKCAPKTF---WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLM 294
             DE   P+VE     P+ F    +  G+  + +  V G+P P + W  +G   +  R  + 
Sbjct: 27951 DENVPPIVE---FGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVE-IEKRMNME 28006

Query: 295   YRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQ 348
               D  G   L V       RG+Y   A+N++G   + +++ V++   +   P++
Sbjct: 28007 ITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIR 28060



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 50/248 (20%), Positives = 90/248 (36%), Gaps = 25/248 (10%)

Query: 1384  SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGT----VTLRAGSTATS 1439
             S P A+V W  NG  +    ++          L +  C   D+GT     T   G  +  
Sbjct: 32399 SKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDY 32458

Query: 1440  ARLHV-----------RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQ 1488
             A L V           R  E +      ++   E   V    +T  + A+ +VR V+   
Sbjct: 32459 ATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQM 32518

Query: 1489  PLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLED 1548
                 ++R S++   H     +    L +      +S  +++  R        R+L     
Sbjct: 32519 T---ETRESLSSYEHSASAEMKSAALEE------KSLEEKSTTRKIKTTLAARILTKPRS 32569

Query: 1549  VTISEGGSATFQLELSQEGV-TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG 1607
             +T+ EG SA F  +   E V T  W R G  L    +  + +  ++    ++ +  +D G
Sbjct: 32570 MTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEG 32629

Query: 1608  CVSFTADS 1615
               S   ++
Sbjct: 32630 NYSVVVEN 32637



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 26/108 (24%), Positives = 39/108 (36%), Gaps = 1/108 (0%)

Query: 229   PPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
             P E      D+  AP ++        +   E  + + +  + GKP P + W     PL  
Sbjct: 19966 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLAT 20025

Query: 289   DRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             D  R+          L V  CQ  D G Y    +N AG     + + V
Sbjct: 20026 D-TRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 20072



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 61/268 (22%), Positives = 96/268 (35%), Gaps = 52/268 (19%)

Query: 312   KDRGLYVCAARNSAGQTLSAVQ----LHVKEPRLRF---TRPLQDVEGREHGIAVLECKV 364
             KD  + V AAR S G  + + +      VK   +     +  +    G E G     CK+
Sbjct: 31532 KDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYVCKI 31591

Query: 365   PNSRIPT--AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM---RGRVR 419
              N    T   W+   ++L    KYE   E  V  L +  +   DDG Y C++    G   
Sbjct: 31592 ENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 31651

Query: 420   TVANVTVKG----------PILKRLPRKLDVLE-------------------GENAVLLV 450
             + A + VKG            +K++ R+ D +                    GEN    V
Sbjct: 31652 SYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGV 31711

Query: 451   E-TLEAGVEGRWSRDGEEL-------PVICQSSSGHMHALVLPGVTREDAGEVTFSLGN- 501
               T+       W + G+++           +S  G ++ L +  VT +D  E T    N 
Sbjct: 31712 TITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG-LYQLTINSVTTDDDAEYTVVARNK 31770

Query: 502   -SRTTTLLRVKCVKHSPPGPPILAEMFK 528
                 +   ++    H PP    L  MFK
Sbjct: 31771 YGEDSCKAKLTVTLHPPPTDSTLRPMFK 31798



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 5/116 (4%)

Query: 223   LLQVHQPPESPP---ADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIE 278
             ++ V++   S P   A P  A   V+EP +K A  ++ V  G+  K    + G+P+P I 
Sbjct: 23203 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 23262

Query: 279   WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             W  +G P L    R+   D      L +      D G Y     N  GQ  +++++
Sbjct: 23263 WTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEI 23317



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 1284  GGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCD 1342
             G DL++ + + G   P + W KDGE L    RV +E+     VL ++     D G+Y   
Sbjct: 24326 GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVT 24385

Query: 1343  A 1343
             A
Sbjct: 24386 A 24386



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V+ G   +   YV GKP P + W+   R  LP    +         V+K   CQ   +G+
Sbjct: 16536 VHAGGVIRIIAYVSGKPPPTVTWNMNER-TLPQEATIETTAISSSMVIK--NCQRSHQGV 16592

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y   A+N AG+    + + V
Sbjct: 16593 YSLLAKNEAGERKKTIIVDV 16612



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 32/80 (40%), Gaps = 1/80 (1%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V  G   +F   + G P P  +W  +G  +  D    +  D     VL +  C  +D G 
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS-VLTIKNCLRRDTGE 17580

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y     N+AG    AV L V
Sbjct: 17581 YQITVSNAAGSKTVAVHLTV 17600



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 1/68 (1%)

Query: 1274  AAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
             A +T V +  G D+++++   G P   V W KD + L S  R  +E   +  +L +    
Sbjct: 27276 ALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVT 27335

Query: 1333  SGDAGEYL 1340
               D G+Y+
Sbjct: 27336 RNDTGKYI 27343



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 1/50 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             P PP+        +++V L W+PP     +P + Y +ER E G ++WI+C
Sbjct: 13292 PSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 13341



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 4/92 (4%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
             +PPG P    +    + +V L W  PE    +    Y +E Q+V   +W +C +      
Sbjct: 30031 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKC-NTTPTKI 30089

Query: 575   VEVPGDCVPSEGDYRFRI--CTVSGHGRSPHV 604
              E     +P   +YRFR+  C   G G    V
Sbjct: 30090 REYTLTHLPQGAEYRFRVLACNAGGPGEPAEV 30121



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + V V    +A  +CV+  E    V+W KG   + +S++    ADG +H L++  +   D
Sbjct: 11493 KDVTVPERRQARFECVLTREAN--VIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDD 11550

Query: 79    AGVY 82
              GVY
Sbjct: 11551 EGVY 11554



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 3/106 (2%)

Query: 231   ESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
             E    D  EAP   ++    A  T  V  G   +    V GKPEP+I W  +   +L   
Sbjct: 13678 EIQAVDTQEAPEIFLDVKLLAGLT--VKAGTKIELPATVTGKPEPKITW-TKADMILKQD 13734

Query: 291   RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             +R+   +      + ++  +  D G Y+  A N  G+  + V+++V
Sbjct: 13735 KRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 13780



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 17/49 (34%), Positives = 29/49 (59%), Gaps = 1/49 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQ 565
             PGPP   ++F   ++ + LTW PPE    +    Y +ER+EV ++ W++
Sbjct: 29932 PGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVR 29980



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 6/88 (6%)

Query: 1725  LRSVSAREGDGATFECTVSEVET-TGRWELGGRPLRPGARVRIRQEG-KKHILVLSELRA 1782
             L +   +EG    FE  VS +   T +WE  G+PL  G  + I  EG   + L + +   
Sbjct: 31801 LANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLP 31860

Query: 1783  EDAGEVRF----QAGPAQSLALLEVEAL 1806
             ED G  R      AG     A L+VE L
Sbjct: 31861 EDTGYYRVTATNTAGSTSCQAHLQVERL 31888



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFSIEKAGA 574
             PGPP   ++    K ++L++W PP     +P   Y LE++E GS  W  +    I K G 
Sbjct: 15599 PGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGL 15658

Query: 575   VEVPGDCVPS--EG-DYRFRICTVSGHGRSP 602
               V  + VP   EG  Y+FR   ++  G  P
Sbjct: 15659 KGVEFN-VPRLLEGVKYQFRAMAINAAGIGP 15688



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 129/621 (20%), Positives = 223/621 (35%), Gaps = 84/621 (13%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PP PP    +    + +  L W+ PE    +  + Y +E Q  G+E W      +   AV
Sbjct: 24212 PPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAV 24271

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS-PHV----VFHGSAHLVPTARLVAGLEDVQVYDG 630
              V G  + S  +Y+FR+   +  G+S P V    V      + P+ +L      +Q   G
Sbjct: 24272 -VTG--LSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQA--G 24326

Query: 631   EDAVFSLDLSTIIQG----TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
             ED    +++  I +     +W  +GE LK             R  +E+      L +   
Sbjct: 24327 ED--LKIEIPVIGRPRPNISWVKDGEPLKQ----------TTRVNVEETATSTVLHIKEG 24374

Query: 687   KHQDSG---ALVGFSCPGVQDSAALTIQESPVHILSPQ--DRVSLTFT--TSERVVLT-- 737
                D G        S     ++ ++ + E P   + P   D VS  F   + E    T  
Sbjct: 24375 NKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGG 24434

Query: 738   CELS------RVDFPATWYKDGQKVEESELLVVKM-DGRKHRL-ILPEAKVQDSGEFECR 789
             C++S      R     TW+     V  + + + K+  G +++  I  E +   S   + +
Sbjct: 24435 CQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSK 24494

Query: 790   TEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR--WYKDGQEV 847
                        +   P     P    FV +I+ + +++       D   +   Y   Q+ 
Sbjct: 24495 ---------AVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKE 24545

Query: 848   EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY-----P 902
             + S   V  N+ P +      T   +G E++     E        + VS   V      P
Sbjct: 24546 KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP 24605

Query: 903   SGKVYVAAVRLERVVLT---------CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVR 953
              G+     +    V L           ++     E +   DG  +  S   +L+ E TV 
Sbjct: 24606 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 24665

Query: 954   RLV------LPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECV 1007
              LV         +    +G +    D   A       + P   + P+ +  ++    E  
Sbjct: 24666 GLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETF 24725

Query: 1008  VLMCELSREDAP-VRWYKDGLEVEESEA-LVLERDGPRCRLVLPAAQPEDGGEFVCD--- 1062
             VL  ++  +  P V W KDG E+EE+ A + ++    +  LV+      DGG+++     
Sbjct: 24726 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 24785

Query: 1063  -AGDDSAFFTVTV---TAPPE 1079
               G  S   TV V     PPE
Sbjct: 24786 VGGTKSIPITVKVLDRPGPPE 24806



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/146 (20%), Positives = 63/146 (43%), Gaps = 7/146 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DGE L    +     +     L +    ++D G+ T +  NS  T    +  +    
Sbjct: 24345 WVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 24404

Query: 518   PGPPILAEMF-KGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PGPP+    F +   + V+++W+PP          Y +E+++  +  W    +      +
Sbjct: 24405 PGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTI 24464

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             ++    + +  +Y+FRI   + +G+S
Sbjct: 24465 KITK--LKTGTEYQFRIFAENRYGKS 24488



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 190/979 (19%), Positives = 339/979 (34%), Gaps = 168/979 (17%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQ---EVGSEDWIQC-FSIEKA 572
             PG P + ++ +   +TV L W  P     +  + Y +ER+   EVG   W++C ++I   
Sbjct: 28942 PGRPEVTDVTR---STVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSD 28998

Query: 573   GAVEVPGDCVPSEGD-YRFRICTVSGHG------RSPHVVFHGSAHLVPTARLVAGLED- 624
                 V      SEGD Y FR+   +  G       S   V     +  P A L A L   
Sbjct: 28999 NFFTVTA---LSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGD 29055

Query: 625   -VQVYDGEDAVFSLDLSTIIQGT------WFLNGEELKSNEPEGQVEPGALRYRIEQKGL 677
              V +  G D V    L   + G       W    +EL   E          +  ++  G 
Sbjct: 29056 LVTIRAGSDLV----LDAAVGGKPEPKIIWTKGDKELDLCE----------KVSLQYTGK 29101

Query: 678   QHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
             +   ++      DSG     +      + A+++    +    P  +++++  T E+  L 
Sbjct: 29102 RATAVIKFCDRSDSGKYT-LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLA 29160

Query: 738   CELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
               L + D  A   +   ++ E S L  V ++G    L     ++  + E+  R   V+ +
Sbjct: 29161 WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKY 29220

Query: 797   F-GVTVQDPPV----------------HIVDPREHVFVHAITSEC-----VMLACEVDRE 834
               GV V+  P+                 +   +EH+ +     E      +       RE
Sbjct: 29221 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKRE 29280

Query: 835   DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
                +RW +  +     D+VV +         L  T   +G ++Q       A      ++
Sbjct: 29281 KKSLRWTRVNK-----DYVVYDTR-------LKVTSLMEGCDYQFRVTAVNAAGNSEPSE 29328

Query: 895   VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTK---DGEEVVESPALLLQKEDT 951
              S++I               RVV T +       + WTK   DG   +    L +Q++DT
Sbjct: 29329 ASNFISCREPSYTPGPPSAPRVVDTTKHS---ISLAWTKPMYDGGTDIVGYVLEMQEKDT 29385

Query: 952   -----------VRRLVLPAVQLEDSGEYLCEIDDESA------SFTVTVTEPPVRIIYPR 994
                        +R        L+   +Y   +   +       S ++   EP  RI  P 
Sbjct: 29386 DQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPD 29445

Query: 995   DEVT---LIAVTLEC---VVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLV 1047
              E+       VT+     + LM  +S    PV  W K G+++  +   +++       L+
Sbjct: 29446 LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDL--ASRAIIDTTESYSLLI 29503

Query: 1048  LPAAQPEDGGEFVCDAGDDSAFFTVTVTA---------PPERIVHPAARSLDLHFGAP-- 1096
             +      D G++  +A + S   + TV           P  ++   +  S+ + +  P  
Sbjct: 29504 VDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 29563

Query: 1097  --GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDA---GEY 1151
               G       V    + +R +K  +  + S  L   +     T+      PE+    GE 
Sbjct: 29564 DGGAPVNNYIVEKREAAMRAFKT-VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE- 29621

Query: 1152  VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVV--------LSCELSRAGA- 1202
              CET    +   V L   P +   ++ T S + +A  +P+            E  +AG  
Sbjct: 29622 PCETSDAVLVSEVPLV--PAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTE 29679

Query: 1203  ---------PVVWSHNGRPVQEGEG--LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAP 1251
                      P V  H    + EGE     + A+  + V                   + P
Sbjct: 29680 RWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGV-------------------SEP 29720

Query: 1252  GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA 1310
                  + TVQ       +      Q  +    G  +ELV+ ++G P     W+  G +L 
Sbjct: 29721 RETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR 29780

Query: 1311  SQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLT 1370
                RV +E       L ++     D GEY  +    +     +++  +L K      P+ 
Sbjct: 29781 ESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIK 29840

Query: 1371  VHEGDDATFRCEVSPPDAD 1389
             + E D  +      PP+ D
Sbjct: 29841 IDEIDATSITISWEPPELD 29859



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 50/188 (26%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 705  SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVV 764
            SA  + Q+    + +P  + S T   +E   L  +    D P T YK    VE  + + V
Sbjct: 847  SATSSAQKITKSVKAPTVKPSETRVRAEPTPLP-QFPFADTPDT-YKSEAGVEVKKEVGV 904

Query: 765  KMDG---RKHRLIL---PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
             + G   R+ R  +    EAKV ++       E         +   P  +V   ++V V 
Sbjct: 905  SITGTTVREERFEVLHGREAKVTETARVPAPVE---------IPVTPPTLVSGLKNVTV- 954

Query: 819  AITSECVMLACEVDREDAP-VRWYKDGQEVEES-DFVVLENEGPHRRLVLPATQPSDGGE 876
             I  E V L C +    +P V WY++  ++E S DF +    G   RL++      D G 
Sbjct: 955  -IEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG-IARLMIREAFAEDSGR 1012

Query: 877  FQCVAGDE 884
            F C A +E
Sbjct: 1013 FTCSAVNE 1020



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 3/92 (3%)

Query: 332  VQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIE 390
            V++ V  P L     L++V   E     LEC +     PT  W+RED ++     ++   
Sbjct: 936  VEIPVTPPTL--VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993

Query: 391  EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
            +  + RL+I    A+D G + C       TV+
Sbjct: 994  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVS 1025



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 33/111 (29%), Positives = 46/111 (41%), Gaps = 7/111 (6%)

Query: 229   PPESPP---ADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
             P E+ P   A+P E PA  VE          +  GK  +    V G+P P   W  E   
Sbjct: 15087 PGETQPVTVAEPQEPPA--VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGE 15144

Query: 286   LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             L  D+ R++  +      L +     KD G YV  A NS G   +A ++ V
Sbjct: 15145 L--DKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 15193



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 23/83 (27%), Positives = 35/83 (42%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    +   V G+PPP V W    + L     +   A  +   +++     +  GVY
Sbjct: 16536 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSS--MVIKNCQRSHQGVY 16593

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+N AGE      V VL+ P
Sbjct: 16594 SLLAKNEAGERKKTIIVDVLDVP 16616



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 21/90 (23%), Positives = 36/90 (40%), Gaps = 2/90 (2%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
             G + +++  + G P P + W K G  L  + R++         L +      D G Y   
Sbjct: 23244 GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGIT 23303

Query: 86    ARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
               N  G+  A+  +  L+ P  DP   P +
Sbjct: 23304 VANVVGQKTASIEIVTLDKP--DPPKGPVK 23331



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 93/414 (22%), Positives = 145/414 (35%), Gaps = 55/414 (13%)

Query: 226   VHQPPES--PPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             + +P +S  P    DE   P +        T  VN G+  +    V GKP P IEW   G
Sbjct: 23604 ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW-LRG 23662

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV------- 336
                + +  R   ++ D   +L V      D G Y+  A N AG     V + V       
Sbjct: 23663 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 23722

Query: 337   -----------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW-FREDQRLLPCR 384
                        ++  L ++ PLQD  G +    V+E K   SR+  AW     + +    
Sbjct: 23723 EGPVQVTGVTSEKCSLTWSPPLQD-GGSDISHYVVE-KRETSRL--AWTVVASEVVTNSL 23778

Query: 385   KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP-ILKRLPRKLDVLEG 443
             K  ++ EG     +   +  +  G+      G     A V +K P +L   P+ L+V   
Sbjct: 23779 KVTKLLEG--NEYVFRIMAVNKYGV------GEPLESAPVLMKNPFVLPGPPKSLEVTNI 23830

Query: 444   ENAVLLV-----------ETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDA 492
                 + V           E +   VE R  R G    + C         L + G+T +  
Sbjct: 23831 AKDSMTVCWNRPDSDGGSEIIGYIVEKR-DRSGIRW-IKCNKRRITDLRLRVTGLTEDHE 23888

Query: 493   GEVTFS------LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW-KPPEPAP 545
              E   S      +G     T+    C     PGPP  A +    KN++ L W KP     
Sbjct: 23889 YEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGG 23948

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                  Y +E  +   E+W                  +    +Y+ R+C ++  G
Sbjct: 23949 SEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVG 24002



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
             V + DAG+   +L NS       +       PGPP+   + +  K++  +TW+PP     
Sbjct: 19756 VNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGG 19815

Query: 547   TPFI-YRLERQEVGSEDW 563
             +P I Y +++++   + W
Sbjct: 19816 SPIINYVVQKRDAERKSW 19833



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 4/91 (4%)

Query: 514   KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKA 572
             +  PPGPP   E+    KNT  ++WK P     +    Y +ER+E  S  W++      +
Sbjct: 20568 RFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVS 20627

Query: 573   G-AVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
                 +V G  +     Y FR+   +  G  P
Sbjct: 20628 DLRCKVTG--LQEGSTYEFRVSAENRAGIGP 20656



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 1/82 (1%)

Query: 461   WSRDGEELPVICQSSSGHMHA-LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
             WSR+  E     Q   G  +  L +    R DAG+    L NS  +    V       PG
Sbjct: 24058 WSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPG 24117

Query: 520   PPILAEMFKGHKNTVLLTWKPP 541
             PP    + +  K++  L W+PP
Sbjct: 24118 PPQNLAVKEVRKDSAFLVWEPP 24139



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 18/64 (28%), Positives = 28/64 (43%), Gaps = 3/64 (4%)

Query: 1657  ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAG---PVRLT 1713
             A V W KDG  L  + R+ + +  T   L ++     D GTY   V  +      P+ + 
Sbjct: 25424 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITII 25483

Query: 1714  VRER 1717
             V +R
Sbjct: 25484 VLDR 25487



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 269   VMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQ 327
             V GKPEP+I W    + L L ++  L Y  +    V+K  +C   D G Y    +N++G 
Sbjct: 29071 VGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIK--FCDRSDSGKYTLTVKNASGT 29128

Query: 328   TLSAVQLHV 336
                +V + V
Sbjct: 29129 KAVSVMVKV 29137



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 22/81 (27%), Positives = 30/81 (37%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G    L   V G PPP + W K    L     L   +   +  L        DAG Y+ 
Sbjct: 19707 AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYIL 19766

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N+ G+      V VL+ P
Sbjct: 19767 TLENSCGKKEYTIVVKVLDTP 19787



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 8/102 (7%)

Query: 1351  LVSVEEPLLVKLVSELTPLTVHEGDDATFRCE-VSPPDADVTWLRNGAVVTPGPQVEMAQ 1409
             L S E P + K   E+  +T   G+ A   C+ V  P  D+ W R G  +    + +M+ 
Sbjct: 30527 LTSGEAPGIRK---EMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSS 30583

Query: 1410  NGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRET 1447
             +G +  LT+   +  D G  T  A    G   TS++L ++ T
Sbjct: 30584 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 30625



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 10/128 (7%)

Query: 1775  LVLSELRAEDAGEVRFQAGPAQS---LALLEVEALPLQMCRHPPREKTVLVGRRAVLEVT 1831
             +V+S  R    G +R Q G + +   +A +E+  +  Q+  H   E+   V  + V ++ 
Sbjct: 31536 MVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIM-HAVGEEGGHV--KYVCKIE 31592

Query: 1832  VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDST 1887
                    V W     +L   +KYE+        L + D+   D GTY C+     G+DS+
Sbjct: 31593 NYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS 31652

Query: 1888  HTRLLVEG 1895
             +  L V+G
Sbjct: 31653 YAELFVKG 31660



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 51/238 (21%), Positives = 89/238 (37%), Gaps = 41/238 (17%)

Query: 965   SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
             S EY   +  E+    V V+EPP+    P   VTL+ VT           R  A ++W K
Sbjct: 25275 SNEYGIGLPAETTE-PVKVSEPPL----PPGRVTLVDVT-----------RNTATIKWEK 25318

Query: 1025  ---DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVT----AP 1077
                DG        + ++  G          +  +       AG++  F    V     + 
Sbjct: 25319 PESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSD 25378

Query: 1078  PERIVHPA-ARSLDLH---------FGAPGRVELRCEVAPAG---SQVRWYKDGLEVEAS 1124
             P ++  P  AR +++          F    R +L+ +V   G   + V W KDG  ++ +
Sbjct: 25379 PRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKET 25438

Query: 1125  DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
               + + +     +L++  A  ED G Y     + A +  V     P+  + L+    P
Sbjct: 25439 TRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITV-----PITIIVLDRPGPP 25491



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 8/116 (6%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKH-SPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
             V  E+A  V  + G SR      +KC +  +PPGPP + ++    K TV L W  P    
Sbjct: 28227 VMAENAAGVGPASGISRL-----IKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDG 28281

Query: 546   ETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
                 I Y +E  +    DW +  + E           + +  +Y+FR+  ++G G+
Sbjct: 28282 GMEIIGYIIEMCKADLGDWHK-VNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 28336



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 30/114 (26%), Positives = 48/114 (42%), Gaps = 7/114 (6%)

Query: 489   REDAGEVTFSLGN--SRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
             R D G       N   R T ++ V  +    PGPP   ++      + LLTW PP     
Sbjct: 13755 RSDTGTYIIEAVNVCGRATAVVEVNVL--DKPGPPAAFDITDVTNESCLLTWNPPRDDGG 13812

Query: 547   TPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
             +    Y +ER+   SE W +  S  K    +     +P++ +Y FR+   + +G
Sbjct: 13813 SKITNYVVERRATDSEVWHKLSSTVKDTNFKAT-KLIPNK-EYIFRVAAENMYG 13864



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 19/79 (24%), Positives = 36/79 (45%)

Query: 925   PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT 984
             P   V W KDG+EV  S  L ++ +     L +P     D+G Y   ++++  S T ++ 
Sbjct: 14414 PVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASIN 14473

Query: 985   EPPVRIIYPRDEVTLIAVT 1003
                + +  P  ++    +T
Sbjct: 14474 VKVIGLPGPCKDIKASDIT 14492



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 16/55 (29%), Positives = 30/55 (54%)

Query: 838   VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
             V W+KDG+EV+ SD + ++N+     L +P +  +D G +     ++    T +I
Sbjct: 14418 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASI 14472



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 17/40 (42%), Positives = 24/40 (60%)

Query: 1112  VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
             V W+KDG EV+ASD L +  +  +  L +P +   DAG Y
Sbjct: 14418 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 14457



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 18/57 (31%), Positives = 29/57 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT 980
             +P    +W K  +EVV S  L + K D+   L++  V  +DSG Y    ++ S + T
Sbjct: 18925 KPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDT 18981



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 15/149 (10%)

Query: 748   TWYKDGQKV---EESELLVVKMDGRKHRLILPEAKVQDSGEF------ECRTEGVSAFFG 798
             TWYK GQK+   +  +    + D   ++L +      D  E+      +   +   A   
Sbjct: 31722 TWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLT 31781

Query: 799   VTVQDPPVH--IVDPREHVFVHAITSECVMLACEVDREDAP---VRWYKDGQEVEESDFV 853
             VT+  PP    +    + +  +A   E   +  E+     P   ++W KDGQ +     +
Sbjct: 31782 VTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNI 31841

Query: 854   VLENEG-PHRRLVLPATQPSDGGEFQCVA 881
              + +EG  +  L +  T P D G ++  A
Sbjct: 31842 EIIHEGLDYYALHIRDTLPEDTGYYRVTA 31870



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 18   PRPVRVVSGAEAELKC--------VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            PRP+ ++ G   +  C        V +       VW K GQ++  S+R+    D   H L
Sbjct: 2353 PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2412

Query: 70   LLTAALPTDAGVY 82
            L+      DAG Y
Sbjct: 2413 LIEDMTKEDAGNY 2425



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 18/60 (30%), Positives = 30/60 (50%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             LV+  VTR D+G    +L N+  +    V       P  P+   + +  K++V L+W+PP
Sbjct: 25163 LVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPP 25222



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 41/171 (23%), Positives = 64/171 (37%), Gaps = 28/171 (16%)

Query: 63    DGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             D +E    +T   P D   +   ARNA G        T+  P  S   +   +  +P   
Sbjct: 27907 DVSECQYTVTGLSPGDRYEFRIIARNAVG--------TISPPSQSSGIIMTRDENVP--- 27955

Query: 123   SGEGAPVFLTGPR---SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                  P+   GP       +  G  + +     G P P + W KDG+ +++  +      
Sbjct: 27956 -----PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---- 28006

Query: 180   QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPP 230
                   D  G S +L +  A     GVY   A+NA G A+A   ++V   P
Sbjct: 28007 ----ITDVLG-STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 28052



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 22/91 (24%), Positives = 41/91 (45%), Gaps = 1/91 (1%)

Query: 1183  LCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG 1241
             L +  GE + +   +     P V W  +G  +++   +E+        L ++ A   H G
Sbjct: 27968 LIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 28027

Query: 1242  LYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
             +YT ++  A G+      V+V + P +VV P
Sbjct: 28028 VYTVEAKNASGSAKAEIKVKVQDTPGKVVGP 28058



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 39/167 (23%), Positives = 65/167 (38%), Gaps = 32/167 (19%)

Query: 453   LEAGVEGR------WSRDGEELPVICQSSS----GHMHALVLPGVTREDAGEVTFSLGNS 502
             L+A V G+      W++  +EL  +C+  S    G     V+    R D+G+ T ++ N+
Sbjct: 29067 LDAAVGGKPEPKIIWTKGDKELD-LCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNA 29125

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWK-PPEPAPETPFIYRLERQEVGSE 561
               T  + V       PGP     + +  +    L W  P E        Y +ER+E    
Sbjct: 29126 SGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRL 29185

Query: 562   DWIQCFSIEKAGAVEVPGDC---------VPSEGDYRFRICTVSGHG 599
             +W           V V G+C         +    +Y FR+  V+ +G
Sbjct: 29186 NW-----------VIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYG 29221



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 1/67 (1%)

Query: 1721  VLSELRSVSAREGDGATFEC-TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
             +L++ RS++  EG+ A F C T  E   T  W   G+ L   AR ++     K    +S 
Sbjct: 32563 ILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISS 32622

Query: 1780  LRAEDAG 1786
             ++A D G
Sbjct: 32623 VQASDEG 32629



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 9/97 (9%)

Query: 139   VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
             V  G ++ L     G PEP + W K  M L +        +     E+ P  S  + I+ 
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITI-----ENVPKKS-TVTIVD 13752

Query: 199   ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPA 235
             ++  D+G Y+  A N  G A A   + V   P  P A
Sbjct: 13753 SKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAA 13789



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 32/111 (28%), Positives = 44/111 (39%), Gaps = 11/111 (9%)

Query: 134   PRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193
             P    +  G ++ +     G P PT  W+K     DEV  SSH A+          +S  
Sbjct: 18905 PEQITIKAGKKLRIEAHVYGKPHPTCKWKK---GEDEVVTSSHLAVHKA------DSSSI 18955

Query: 194   LRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQP-PESPPADPDEAPA 242
             L I      DSG Y   A N+ G   Q   ++ +  P P  PP D  +  A
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDA 19006



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 13/89 (14%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             RP  EV+W +D  E ++  +  ++   +   L++  V   DSG+Y+  +++ S S +  V
Sbjct: 21887 RPAPEVKWARDHGESLDKAS--IESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 21944

Query: 984   TEPPVRII----YPRD----EVTLIAVTL 1004
                 VR++     P+D    EVT  +VTL
Sbjct: 21945 N---VRVLDTPGPPQDLKVKEVTKTSVTL 21970



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 1640  VTEGDTATFECEL-SQALADVTWEKDGNAL-TPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             V  G+T   E ++  + + DV W KDG  L   + R+ +++   +  L ++ C  +D G 
Sbjct: 24719 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 24778

Query: 1698  YSCA---VGTARAGPVRLTVRER 1717
             Y      VG  ++ P+ + V +R
Sbjct: 24779 YILKLSNVGGTKSIPITVKVLDR 24801



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             C  + PPGPP   E+    K+++++TW  P     T    Y LE+++     W +C
Sbjct: 24896 CNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKC 24951



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 29/119 (24%), Positives = 53/119 (44%), Gaps = 10/119 (8%)

Query: 491   DAGEVTFSLGNSRTTTLLRVKCVKHSPPGPP----ILAEMFKGHKNTVLLTWKPPE-PAP 545
             DAG    +  NS  TT   +  V    PGPP    +++++    + +V L W+PP+    
Sbjct: 26543 DAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDI---TEESVTLKWEPPKYDGG 26599

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                  Y L ++E  +  W +  +      ++V    + +  +Y+FRI   +  G S H+
Sbjct: 26600 SQVTNYILLKRETSTAVWTEVSATVARTMMKVMK--LTTGEEYQFRIKAENRFGISDHI 26656



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 24/92 (26%), Positives = 36/92 (39%), Gaps = 2/92 (2%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             R+   + V  G    L   + G+P P+  W K GQ +  S+R           L++  A 
Sbjct: 30141 RYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI--SKRAMIATSETHTELVIKEAD 30198

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS 107
               D+G Y     N  G+      V V+  P S
Sbjct: 30199 RGDSGTYDLVLENKCGKKAVYIKVRVIGSPNS 30230



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 33/158 (20%), Positives = 60/158 (37%), Gaps = 22/158 (13%)

Query: 720   PQDRVSLTFTTSERVVLTCELSRVDFP--------ATWYKDGQKVEESELLVVKMDGRKH 771
             P  + ++   T + +V+  E   +  P         +W+KDG++V+ S+ L +K D    
Sbjct: 14383 PDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISA 14442

Query: 772   RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEV 831
              L +P++   D+G +    E        ++    + +  P + +    IT     L  E 
Sbjct: 14443 HLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEP 14502

Query: 832   DRED--APVRWYKDGQEVEESDFVVLENEGPHRRLVLP 867
                D   P+  Y            VLE     RR  +P
Sbjct: 14503 PEFDGGTPILHY------------VLERREAGRRTYIP 14528



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 1638  LEVTEGDTATFECEL-SQALADVTWEKDGNA--LTPSPRLRLQALGTRRLLQLRRCGPSD 1694
             L V  GDT   E  +  +   +V W KD +A  LT SPR+++          L +   SD
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSD 18270

Query: 1695  AGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV-SAREGDGATFECTV 1742
              G Y     T  AG     V   TV VL +   V + +  D ++  CTV
Sbjct: 18271 GGKY-VVTATNTAGSF---VAYATVNVLDKPGPVRNLKIVDVSSDRCTV 18315



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 17/173 (9%)

Query: 1096  PGRVELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
             PG   +RC  AP    Q  +   GLE +A    Q  A   T     P ++P D    + E
Sbjct: 19232 PGDKWVRCNTAPHQIPQEEYTATGLEEKAQ--YQFRAIARTAVNISPPSEPSDPVTILAE 19289

Query: 1155  TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPV 1213
                  I  +V +              S L V  G  V L   +     P V W  +G  +
Sbjct: 19290 NVPPRIDLSVAMK-------------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLL 19336

Query: 1214  QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
             +  EG+++  +     L + +     +G YT  +  + G+ S +  ++V + P
Sbjct: 19337 KPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K+TV L W KP          Y +E Q  GS+ W    +++  G   
Sbjct: 20965 PSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVK--GLEC 21022

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V  +    E +Y F++  V+  GRS
Sbjct: 21023 VVRNLTEGE-EYTFQVMAVNSAGRS 21046



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 26/102 (25%), Positives = 41/102 (40%), Gaps = 8/102 (7%)

Query: 232   SPPADP-------DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGR 284
             SPP++P       D+  AP ++       T  +  G+  +    V G+P P +EW  +G+
Sbjct: 21441 SPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGK 21500

Query: 285   PLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG 326
               L    +L  +  D    L       +D G Y   A N  G
Sbjct: 21501 E-LEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGG 21541



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 20/87 (22%), Positives = 36/87 (41%)

Query: 833   REDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
             R  A V W KDGQ ++E+  V + +      L +      D G ++    +     TV I
Sbjct: 25421 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 25480

Query: 893   TDVSSWIVYPSGKVYVAAVRLERVVLT 919
             T +      P G + +  V  + + ++
Sbjct: 25481 TIIVLDRPGPPGPIRIDEVSCDSITIS 25507



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K++V LTW  PE    +  + Y +E  E G ++W++C ++ K+    
Sbjct: 26375 PSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKC-AVAKSTHHV 26433

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V G  +    +Y FR+   +  G S
Sbjct: 26434 VSG--LRENSEYFFRVFAENQAGLS 26456



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD---ESASFT 980
             RP   V W KD + +       ++  D+   L +P V   D+G+Y+  I++   E  S T
Sbjct: 27298 RPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 27357

Query: 981   VTV 983
             V+V
Sbjct: 27358 VSV 27360



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 23/89 (25%), Positives = 35/89 (39%), Gaps = 9/89 (10%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G+++VL    GG PEP + W K    LD          +      G  A+  ++      
Sbjct: 29062 GSDLVLDAAVGGKPEPKIIWTKGDKELD-------LCEKVSLQYTGKRATAVIKF--CDR 29112

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPP 230
              DSG Y    +NA G      +++V   P
Sbjct: 29113 SDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 2/75 (2%)

Query: 1637  DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
             D+    G+ A   C++  + L D+ W + G  L  S + ++ + G    L +      D 
Sbjct: 30541 DVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 30600

Query: 1696  GTYSCAVGTARAGPV 1710
             G Y+C + T   G V
Sbjct: 30601 GVYTC-IATNEVGEV 30614



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 18/76 (23%), Positives = 32/76 (42%)

Query: 37    GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
             G P P   W  G + L   +R+      A   L+++ +  +D G+Y  +  N        
Sbjct: 13420 GYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGE 13479

Query: 97    AAVTVLEPPASDPELQ 112
               V V+  P++  EL+
Sbjct: 13480 IDVNVIARPSAPKELK 13495



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
             PP PP   E+    KNT  L W  PE    +P   Y +E+++V  + W
Sbjct: 14083 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGW 14130



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 8/99 (8%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADG----AEHG--LLLTAALP 76
             +G++  +  V+ G P P   WE  G+   A +      P D     AE+   +++     
Sbjct: 15824 AGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKR 15883

Query: 77    TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
             +  G Y   A+N AG+  A   V V++ P    +L+ ++
Sbjct: 15884 SHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSD 15922



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 6/70 (8%)

Query: 924   RPWAEVRWTKDGE--EVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF-- 979
             +P+ EV WTKD +  ++  SP + +       +  L   +  D G+Y+    + + SF  
Sbjct: 18228 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVA 18287

Query: 980   --TVTVTEPP 987
               TV V + P
Sbjct: 18288 YATVNVLDKP 18297



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/81 (23%), Positives = 34/81 (41%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G+   +   + G P P V W+    +L  ++R+S         L +  ++  D+G Y  
Sbjct: 28661 AGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFL 28720

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N AG    +  V V+  P
Sbjct: 28721 TLENTAGVKTFSVTVVVIGRP 28741



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 4/93 (4%)

Query: 1432  RAGSTATSARLHVRETELLFLRR-LQDVRAEEGQDVCLEVE-TGRVGAAGAVRWVRGGQP 1489
             R   TA S +  +   E   +R+ ++DV  + G+   L  +  GR      ++W R G+ 
Sbjct: 30515 RPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGR--PLPDIKWYRFGKE 30572

Query: 1490  LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC 1522
             L    +  M+ DG  H L +      D+G Y C
Sbjct: 30573 LIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 30605



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 15/102 (14%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGG-------QQLAASERLSFPADGAEHGLLLTA 73
             V V +G    L  +V G P P V W K G        Q+   + ++F        L++  
Sbjct: 18616 VIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF--------LVIPN 18667

Query: 74    ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
             +   D+G Y     N AGE      V VL+ P    +L+ ++
Sbjct: 18668 STRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSD 18709



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 16/60 (26%), Positives = 30/60 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             +P   V W KDG  +  +  + +  +  +  L L +V  +DSG+Y    ++ S S + T+
Sbjct: 19322 KPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATI 19381



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 14/38 (36%), Positives = 22/38 (57%)

Query: 1114  WYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
             W K G ++  SD  Q+ +   +  LT+ +A  +DAGEY
Sbjct: 20413 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEY 20450



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 1/84 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP    +    K +  L W KP          Y +E Q+VG E WI+  +       
Sbjct: 20672 PPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 20731

Query: 576   EVPGDCVPSEGDYRFRICTVSGHG 599
             +     + ++  Y FRI  ++  G
Sbjct: 20732 QFVVPDLQTKEKYNFRISAINDAG 20755



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 7/97 (7%)

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGLEVEASDALQLGAEGPTRT 1137
             ++ PA + L   F      +L+ +V   G     V W+KD + ++ +  +   +      
Sbjct: 22145 VIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSL 22204

Query: 1138  LTLPHAQPEDAGEYVCETRH---EAI-TFNVILAEPP 1170
             LT+  A  ED G YV +  +   EAI T NVI+ + P
Sbjct: 22205 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 22241



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 38/148 (25%), Positives = 56/148 (37%), Gaps = 23/148 (15%)

Query: 93    AYAAAAVTVL---EPPASDPELQPAER-PLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLT 148
             ++  AAV V    E   S  E++P ER  +P     +     +T      +  GA + L 
Sbjct: 29414 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVT------IRAGASLRLM 29467

Query: 149   CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRIL-AARLPDSGVY 207
                 G P P + W K G+ L              RA      S +L I+      D+G Y
Sbjct: 29468 VSVSGRPPPVITWSKQGIDL------------ASRAIIDTTESYSLLIVDKVNRYDAGKY 29515

Query: 208   VCHARNAHGHAQAGALLQVHQPPESPPA 235
                A N  G   A  L++V+  P   P+
Sbjct: 29516 TIEAENQSGKKSATVLVKVYDTPGPCPS 29543



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 32/110 (29%), Positives = 49/110 (44%), Gaps = 21/110 (19%)

Query: 424 VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDGE-----ELPVIC 472
           +T + P   +  + + VLEG  A     T EA + G       W RDG+      LP + 
Sbjct: 1   MTTQAPTFTQPLQSVVVLEGSTA-----TFEAHISGFPVPEVSWFRDGQVISTSTLPGVQ 55

Query: 473 QSSSGHMHALVLPGVTREDAG----EVTFSLGNSRTTTLLRVKCVKHSPP 518
            S S     L +P VT+ ++G    + T   G + +T  L VK  + +PP
Sbjct: 56  ISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK-AETAPP 104



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 47/196 (23%), Positives = 80/196 (40%), Gaps = 24/196 (12%)

Query: 343 FTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRL----LPCRKYEQIEEGTVRRL 397
           FT+PLQ V   E   A  E  +    +P  +WFR+ Q +    LP  +     +G  +  
Sbjct: 8   FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQI-SFSDGRAKLT 66

Query: 398 IIHRLKADDD--GIYLCEMRGRVRTVANVTVKG----PILKRLPRKLDVLEGENAVLLVE 451
           I    KA+     +      G+  + A + VK     P   +  + + V +G    L V 
Sbjct: 67  IPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVR 126

Query: 452 TLEAGVEG---RWSRDGEELPVICQ---SSSGHMHALVLPGVTREDAG----EVTFSLGN 501
               G+     ++ RDG E+        S  G +++L++     ED+G      T S+G 
Sbjct: 127 V--TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR 184

Query: 502 SRTTTLLRVKCVKHSP 517
           + +T  L V+  +  P
Sbjct: 185 ATSTAELLVQGEEEVP 200



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 22/104 (21%), Positives = 45/104 (43%), Gaps = 2/104 (1%)

Query: 1630  TIVRGPHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPRLRLQALGTRRLLQLR 1688
             TI    HD+ V EG+  +         +  V+W KDG  +  S RL ++       L++ 
Sbjct: 14388 TIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVP 14447

Query: 1689  RCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSARE 1732
             +   +DAG Y+  +   + G    ++  + + +    + + A +
Sbjct: 14448 KSVRADAGIYTITLEN-KLGSATASINVKVIGLPGPCKDIKASD 14490



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 26/112 (23%), Positives = 42/112 (37%), Gaps = 8/112 (7%)

Query: 232   SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR 291
             S    P +   P + P     +   V EG +      + G P P + W ++  P  PD +
Sbjct: 16103 SATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTW-FKAPPKKPDNK 16161

Query: 292   RLMYRDR-------DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
               +  D        D    L +   +  D GLY   A N+ G     ++L+V
Sbjct: 16162 EPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 16213



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 2/88 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PG P    +    K  V L W+ P+    +P + Y +ER+  GS+DW +           
Sbjct: 18101 PGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHY 18160

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPHV 604
             +   CV ++  Y FR+ T +  G S  V
Sbjct: 18161 MVDRCVENQ-IYEFRVQTKNEGGESDWV 18187



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%)

Query: 153   GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHAR 212
             G P+PT+ W+K    L +    +          +    S  L I      DSG Y   AR
Sbjct: 21091 GRPKPTVTWKKGDQILKQTQRVNF---------ETTATSTILNINECVRSDSGPYPLTAR 21141

Query: 213   NAHGHAQAGALLQVHQPPESPPADP 237
             N  G       +QVH  P  PP  P
Sbjct: 21142 NIVGEVGDVITIQVHDIP-GPPTGP 21165



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 13/40 (32%), Positives = 20/40 (50%)

Query: 1659  VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
             VTW+K    L  + R+  +   T  +L +  C  SD+G Y
Sbjct: 21097 VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPY 21136



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 15/53 (28%), Positives = 29/53 (54%), Gaps = 1/53 (1%)

Query: 515   HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             + PP PP   E+    K+++++ W  P+    +  I Y +ER++   + WI+C
Sbjct: 21652 YGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKC 21704



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    +N+V L+W+ PE    +  + Y +E Q  GS+ W  C ++ K     
Sbjct: 22049 PLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATV-KVTEAT 22107

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             + G  +  E +Y FR+   +  G S
Sbjct: 22108 ITG-LIQGE-EYSFRVSAQNEKGIS 22130



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 29/107 (27%), Positives = 40/107 (37%), Gaps = 10/107 (9%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G  V L     G P PT+ W KD    D+   ++         +       ++ I  A  
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKD----DKELQTNALVCVENTTD-----LASILIKDADR 26937

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
              +SG Y    RNA G A A   +Q+   P  PP  P E      E +
Sbjct: 26938 LNSGCYELKLRNAMGSASATIRVQILDKP-GPPGGPIEFKTVTAEKI 26983



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 18/77 (23%), Positives = 33/77 (42%), Gaps = 1/77 (1%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G   K R  + GKP P IEW+ + + L  +    +    D   +L +      + G Y  
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL-IKDADRLNSGCYEL 26945

Query: 320   AARNSAGQTLSAVQLHV 336
               RN+ G   + +++ +
Sbjct: 26946 KLRNAMGSASATIRVQI 26962



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/83 (28%), Positives = 29/83 (34%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +GA   L     G P P  VW K    L  S R       +   L +      DAG Y
Sbjct: 28369 VRAGASIRLFIAYQGRPTPTAVWSKPDSNL--SLRADIHTTDSFSTLTVENCNRNDAGKY 28426

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  N +G       V VL+ P
Sbjct: 28427 TLTVENNSGSKSITFTVKVLDTP 28449


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score =  461 bits (1185), Expect = e-129
 Identities = 389/1568 (24%), Positives = 676/1568 (43%), Gaps = 73/1568 (4%)

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
            K   V E + A+F C +    E  + W  +G  ++    +          +L +   Q  
Sbjct: 5188 KDVTVPERRQARFECVLTR--EANVIWS-KGPDIIKSSDKFDIIADGKKHILVINDSQFD 5244

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
            D G+Y        G+  SA +L V   RL+F  PL+D   +E   A   C++ + ++   
Sbjct: 5245 DEGVYTAEVE---GKKTSA-RLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVV 5300

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            WF+ D +L   R      EG   +L +  +  DD    + +++ +V+ +++ T +  +L+
Sbjct: 5301 WFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDD----ISQIKAQVKELSS-TAQLKVLE 5355

Query: 433  RLPRKLDVLEGENAVLLVE-TLEAGVEG----RWSRDGEEL---PVICQSSSGHMHALVL 484
              P     L  + AV   E TL+  V      +W +DGEE+   P     + G    L +
Sbjct: 5356 ADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKI 5415

Query: 485  PGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPA 544
                 +D GE     G  +T   + V+        P    E+F G      +    P+  
Sbjct: 5416 KKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVH 5475

Query: 545  PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
             +    ++L+ Q + +    +     K   + +    +   G+  F+    + + +S   
Sbjct: 5476 GQ----WKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQ----AANAKSAAN 5527

Query: 605  VFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
            +      L+     +  L DV+V++ ++A F  ++S   +   +L G          Q  
Sbjct: 5528 LKVKELPLI----FITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGT---------QEI 5574

Query: 665  PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
             G  R+ + + G +H +++ +   +D    + F       S  L I+   +  L+P   V
Sbjct: 5575 TGDDRFELIKDGTKHSMVIKSAAFEDEAKYM-FEAEDKHTSGKLIIEGIRLKFLTPLKDV 5633

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
              T    E  V T ELS  +    W+K+ Q++  +  + ++ +G+ H +   +  + D+ 
Sbjct: 5634 --TAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTS 5691

Query: 785  EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDG 844
            +      G+S+   +TV +   +     +      +  + V+L CE+ + DAPV+W+KDG
Sbjct: 5692 QIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDG 5749

Query: 845  QEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSG 904
            +E++ S   V++ +G  R L+L     SD G++ C  G +     + I D    +V P  
Sbjct: 5750 KEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLH 5809

Query: 905  KVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLED 964
             V V      R     E+        W   GE ++++P   +++E  +  LVL   +L+ 
Sbjct: 5810 SVEVMETETAR--FETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQ 5867

Query: 965  SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
            +G    +  +  +S  + V    + ++ P  +VT+ A   E     CELS ED PV WY 
Sbjct: 5868 TGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAG--ETATFDCELSYEDIPVEWYL 5925

Query: 1025 DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHP 1084
             G ++E S+ +V   +G    L L   + ED GE    A D      + V  PP     P
Sbjct: 5926 KGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKP 5985

Query: 1085 AARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQ 1144
                 D          L CEV+   ++V+W+K+G E+  S   ++ A+G  R L +    
Sbjct: 5986 LE---DQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCT 6042

Query: 1145 PEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV 1204
            PED   Y C+ +    + N+ +  P V+FL   T    L V   E     CELSR  A V
Sbjct: 6043 PEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTD---LQVREKEMARFECELSRENAKV 6099

Query: 1205 VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
             W  +G  +++G+  ++ ++G  R+L I          Y+C+   A  +  L+   + A 
Sbjct: 6100 KWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEA- 6158

Query: 1265 PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQ 1324
                V     A   V  T    ++LV  +S PG  V WYK  E +   GR ++   G ++
Sbjct: 6159 ----VFTKNLANIEVSETD--TIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKR 6212

Query: 1325 VLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS 1384
            +L +Q A   DAG Y C  P       V V E L  + +S+   L + EG+ A F C +S
Sbjct: 6213 ILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHE-LAAEFISKPQNLEILEGEKAEFVCSIS 6271

Query: 1385 PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHV 1444
                 V W R+   +  G + ++  +G  R+L ++   L D GT  +  G+   +A L V
Sbjct: 6272 KESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV 6331

Query: 1445 RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHI 1504
             E +L  +  L+D R +E Q+V    E    GA    +W R  + +   S+  + Q   +
Sbjct: 6332 IE-KLRIVVPLKDTRVKEQQEVVFNCEVNTEGAKA--KWFRNEEAIFDSSKYIILQKDLV 6388

Query: 1505 HRLFIHGVILADQGTYGCESHHDR-----TLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
            + L I    L DQ  Y     + R     + A L V    LR++ PL+D+   E  S TF
Sbjct: 6389 YTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTF 6448

Query: 1560 QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
              ++++  VT +W + G ++    +     D ++H L +   G  D G    TA   +  
Sbjct: 6449 WCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSV 6508

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
            A L++ E P   V    D  VTE D A F C+LS+  A+V W ++G  +    + + +  
Sbjct: 6509 AELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKD 6568

Query: 1680 GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
            G+   L ++ C   D   Y+C V   R    RL V E  V ++   + +    G    F 
Sbjct: 6569 GSIHRLIIKDCRLDDECEYACGV-EDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFL 6627

Query: 1740 CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA 1799
              +++ +   +W      +  G + ++  EGK H L + +++  D GE RF A   ++ A
Sbjct: 6628 AELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARA 6687

Query: 1800 LLEVEALP 1807
             LE+ A P
Sbjct: 6688 KLELAAAP 6695



 Score =  439 bits (1128), Expect = e-122
 Identities = 392/1575 (24%), Positives = 667/1575 (42%), Gaps = 85/1575 (5%)

Query: 327  QTLSAVQ---LHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPC 383
            Q L+A+    L VKE  L F  PL+DV   E   A  EC V        W +    +   
Sbjct: 5164 QALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC-VLTREANVIWSKGPDIIKSS 5222

Query: 384  RKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLD--VL 441
             K++ I +G    L+I+  + DD+G+Y  E+ G+ +T A + V G  LK +    D  V 
Sbjct: 5223 DKFDIIADGKKHILVINDSQFDDEGVYTAEVEGK-KTSARLFVTGIRLKFMSPLEDQTVK 5281

Query: 442  EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFS 498
            EGE A  + E     +   W ++  +L     +  SS G  H L +  VT +D  ++   
Sbjct: 5282 EGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 5341

Query: 499  LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-----IYRL 553
            +    +T  L+V  ++  P     L +     K+ + L  +  +  P   F     I   
Sbjct: 5342 VKELSSTAQLKV--LEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPS 5399

Query: 554  ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
             +  + ++   +   I+KA         +  +G+Y   +C         +V     A L+
Sbjct: 5400 PKYSIKADGLRRILKIKKAD--------LKDKGEY---VCDCGTDKTKANVTVE--ARLI 5446

Query: 614  PTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRI 672
               + + G+E   V+ GE A F ++LS   + G W L G+ L ++ P+ +         I
Sbjct: 5447 KVEKPLYGVE---VFVGETAHFEIELSEPDVHGQWKLKGQPLTAS-PDCE---------I 5493

Query: 673  EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
             + G +H LILH  +   +G  V F     + +A L ++E P+  ++P   V +     +
Sbjct: 5494 IEDGKKHILILHNCQLGMTGE-VSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKD 5550

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
                 CE+SR      W K  Q++   +   +  DG KH +++  A  +D  ++    E 
Sbjct: 5551 EAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAED 5610

Query: 793  VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDF 852
                  + ++   +  + P + V   A   E  +   E+  ++  V+W+K+ Q +  +  
Sbjct: 5611 KHTSGKLIIEGIRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRS 5668

Query: 853  VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVY-VAAV 911
            V +++EG    +        D  + +  A    +   +T+ +      Y +GK+     V
Sbjct: 5669 VSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDP---YFTGKLQDYTGV 5725

Query: 912  RLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCE 971
              + V+L CE+ +  A V+W KDG+E+  S   +++ +   R L+L      D G+Y C+
Sbjct: 5726 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 5785

Query: 972  IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEE 1031
               +  S  + + +  ++++ P   V ++    E      E+S +D    W   G  + +
Sbjct: 5786 CGTDKTSGKLDIEDREIKLVRPLHSVEVMET--ETARFETEISEDDIHANWKLKGEALLQ 5843

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDL 1091
            +    ++ +G    LVL   + +  G     A +  +   + V      ++ P     D+
Sbjct: 5844 TPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLK---DV 5900

Query: 1092 HFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
               A       CE++     V WY  G ++E SD +   +EG   TLTL   + EDAGE 
Sbjct: 5901 TVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEV 5960

Query: 1152 VCETRHEAITFNVILAEPPVQFLALETTP-SPLCVAPGEPVVLSCELSRAGAPVVWSHNG 1210
                +      N+ + EPPV+F    T P     V  G   VL CE+SR  A V W  NG
Sbjct: 5961 QLTAKDFKTHANLFVKEPPVEF----TKPLEDQTVEEGATAVLECEVSRENAKVKWFKNG 6016

Query: 1211 RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVV 1270
              + + +  E+ A+G  R L I    P     YTC +         S  + V  P V  +
Sbjct: 6017 TEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDF----KTSCNLNVVPPHVEFL 6072

Query: 1271 APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
             P     +VR       E    LS     V+W+KDG  +    +  +   GA ++L +  
Sbjct: 6073 RP-LTDLQVREKEMARFEC--ELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINK 6129

Query: 1331 ARSGDAGEYLCDA--PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA 1388
                D  EY C+    + S +  V  EE +  K    L  + V E D     CEVS P A
Sbjct: 6130 CLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTK---NLANIEVSETDTIKLVCEVSKPGA 6186

Query: 1389 DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETE 1448
            +V W +    +    + E+   G  RIL ++   L DAG    R  S+ T  ++ V E  
Sbjct: 6187 EVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELA 6246

Query: 1449 LLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLF 1508
              F+ + Q++   EG+         +   +  V+W R  + L    +  +  DG    L 
Sbjct: 6247 AEFISKPQNLEILEGEKAEFVCSISK--ESFPVQWKRDDKTLESGDKYDVIADGKKRVLV 6304

Query: 1509 IHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
            +    L D GTY       R  A L+V  + LR++ PL+D  + E     F  E++ EG 
Sbjct: 6305 VKDATLQDMGTYVVMVGAARAAAHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGA 6363

Query: 1569 TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC--VSFT---ADSLRCAARLI 1623
              +W R    ++   K  I      + L +    L D     VS T    ++++ AA LI
Sbjct: 6364 KAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLI 6423

Query: 1624 VREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRR 1683
            V E  + IV    D+E  E  + TF C++++    + W K+G  +    R+  +    + 
Sbjct: 6424 VEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKH 6483

Query: 1684 LLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVS 1743
            +L ++ CG  D G Y    G  ++    L + E     +  L   +  E D A F C +S
Sbjct: 6484 MLTIKDCGFPDEGEYIVTAGQDKS-VAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLS 6542

Query: 1744 EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEV 1803
              +   +W   GR ++ G + +  ++G  H L++ + R +D  E        +S A L V
Sbjct: 6543 REKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFV 6602

Query: 1804 EALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTH 1863
            E +P+++ R PP++     G   V    +++    V WLR    +  GDK++M S G  H
Sbjct: 6603 EEIPVEIIR-PPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIH 6661

Query: 1864 SLVIHDVRPEDQGTY 1878
             L I D++P DQG Y
Sbjct: 6662 RLQICDIKPRDQGEY 6676



 Score =  394 bits (1013), Expect = e-109
 Identities = 402/1699 (23%), Positives = 685/1699 (40%), Gaps = 129/1699 (7%)

Query: 228  QPPESPPADPDEAPAPVVEPLKCAPKTFWVNE------------GKHAKFRCYVMGKPEP 275
            +P       PDEAP      LK  P  F V E            G  A F C V   P  
Sbjct: 4787 RPGSGGEKPPDEAP--FTYQLKAVPLKF-VKEIKDIILTESEFVGSSAIFECLV--SPST 4841

Query: 276  EIE-WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             I  W  +G  +    +     D      L ++  Q  D G Y C  R    +  S  +L
Sbjct: 4842 AITTWMKDGSNIRESPKHRFIADGKDR-KLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKL 4900

Query: 335  HVKEPRLRFTRPLQD----VEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
             V+E  +RF + L++    V+G+      L C++ N      W R+D +++   K  +I 
Sbjct: 4901 VVEELPVRFVKTLEEEVTVVKGQP---LYLSCEL-NKERDVVW-RKDGKIV-VEKPGRIV 4954

Query: 391  EGTV---RRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-----GPILKRLPRKLDVLE 442
             G +   R L I+     D G Y   +        +  VK        L +  R   V  
Sbjct: 4955 PGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKP 5014

Query: 443  GENAVLLVETLEAGVEGRWSRDGEELPVICQSSS-----GHMHALVLPGVTREDAGEVTF 497
               A+   +  +     +W +  +E+P      +     G+   L +     ED  E   
Sbjct: 5015 KGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAV 5074

Query: 498  SLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLER-- 555
             +   R                    A++  G +   LL  KP E       IY  E   
Sbjct: 5075 EIEGKRYP------------------AKLTLGEREVELL--KPIEDVT----IYEKESAS 5110

Query: 556  --QEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
               E+   D    + ++       P   + +EG  RF         ++  V++  + + +
Sbjct: 5111 FDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQ-ALNAI 5169

Query: 614  PTARL---------VAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
             TA L            L+DV V +   A F   L+      W    + +KS++      
Sbjct: 5170 TTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTREANVIWSKGPDIIKSSD------ 5223

Query: 665  PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
                ++ I   G +H L+++  +  D G        G + SA L +    +  +SP +  
Sbjct: 5224 ----KFDIIADGKKHILVINDSQFDDEGVYTA-EVEGKKTSARLFVTGIRLKFMSPLE-- 5276

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
              T    E     CELS       W+K+  K+  S  +++  +G+ H+L + E  + D  
Sbjct: 5277 DQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDIS 5336

Query: 785  EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH---AITSECVMLACEVDREDAPVRWY 841
            + + + + +S+   + V +      DP   V +H   A+  + + L CEV + D PV+W+
Sbjct: 5337 QIKAQVKELSSTAQLKVLE-----ADPYFTVKLHDKTAVEKDEITLKCEVSK-DVPVKWF 5390

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            KDG+E+  S    ++ +G  R L +      D GE+ C  G +     VT   V + ++ 
Sbjct: 5391 KDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVT---VEARLIK 5447

Query: 902  PSGKVYVAAVRL-ERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960
                +Y   V + E      EL  P    +W   G+ +  SP   + ++     L+L   
Sbjct: 5448 VEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNC 5507

Query: 961  QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV 1020
            QL  +GE   +  +  ++  + V E P+  I P  +V +     +     CE+SRE    
Sbjct: 5508 QLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKDEAKFECEVSREPKTF 5565

Query: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
            RW K   E+   +   L +DG +  +V+ +A  ED  +++ +A D      + +     +
Sbjct: 5566 RWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLK 5625

Query: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140
             + P     D+            E++    +V+W+K+   +  + ++ +  EG T ++T 
Sbjct: 5626 FLTPLK---DVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITF 5682

Query: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 1200
                 +D  +   E    +    + + E    F               + V+L CE+S+A
Sbjct: 5683 KDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTG---KLQDYTGVEKDEVILQCEISKA 5739

Query: 1201 GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV 1260
             APV W  +G+ ++  +   + A+G +R+L ++ A  +  G YTC      G    S  +
Sbjct: 5740 DAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDC----GTDKTSGKL 5795

Query: 1261 QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA 1320
             + +  +++V P      V  T     E    +S       W   GE L      ++++ 
Sbjct: 5796 DIEDREIKLVRP-LHSVEVMETETARFE--TEISEDDIHANWKLKGEALLQTPDCEIKEE 5852

Query: 1321 GARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
            G    L +   R    G     A        + V +P ++ L+  L  +TV  G+ ATF 
Sbjct: 5853 GKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRV-KPRVIGLLRPLKDVTVTAGETATFD 5911

Query: 1381 CEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA 1440
            CE+S  D  V W   G  + P  +V     G    LTLR  +L DAG V L A    T A
Sbjct: 5912 CELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHA 5971

Query: 1441 RLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQ 1500
             L V+E  + F + L+D   EEG    LE E  R  A   V+W + G  +    +  +  
Sbjct: 5972 NLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA--KVKWFKNGTEILKSKKYEIVA 6029

Query: 1501 DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ 1560
            DG + +L IH     D  TY C++   +T   L+V P  +  LRPL D+ + E   A F+
Sbjct: 6030 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFE 6089

Query: 1561 LELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAA 1620
             ELS+E    +W + G ++  G K  I S G    LV+N   L D    S    + R + 
Sbjct: 6090 CELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSG 6149

Query: 1621 RLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALG 1680
             L V E      +   ++EV+E DT    CE+S+  A+V W K    +  + R  +   G
Sbjct: 6150 MLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEG 6209

Query: 1681 TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC 1740
             +R+L ++     DAG Y+C + ++R    ++ V E     +S+ +++   EG+ A F C
Sbjct: 6210 RKRILVIQNAHLEDAGNYNCRLPSSRTDG-KVKVHELAAEFISKPQNLEILEGEKAEFVC 6268

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA- 1799
            ++S+     +W+   + L  G +  +  +GKK +LV+ +   +D G      G A++ A 
Sbjct: 6269 SISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAH 6328

Query: 1800 LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSH 1859
            L  +E L + +   P ++  V   +  V    V+  G    W R    +    KY +   
Sbjct: 6329 LTVIEKLRIVV---PLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQK 6385

Query: 1860 GPTHSLVIHDVRPEDQGTY 1878
               ++L I D   +DQ  Y
Sbjct: 6386 DLVYTLRIRDAHLDDQANY 6404



 Score =  385 bits (988), Expect = e-106
 Identities = 420/1813 (23%), Positives = 709/1813 (39%), Gaps = 111/1813 (6%)

Query: 105  PASDPELQPAERP-------LPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
            P S  E  P E P       +P     E   + LT   S++V  G+  +  C        
Sbjct: 4788 PGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILT--ESEFV--GSSAIFECLVSPSTAI 4843

Query: 158  TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
            T  W KDG  + E          P       G    L I+  +L D+G Y C  R  +  
Sbjct: 4844 TT-WMKDGSNIRE---------SPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKE 4893

Query: 218  AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
              + A L V + P              V  +K   +   V +G+     C +    E ++
Sbjct: 4894 KTSTAKLVVEELP--------------VRFVKTLEEEVTVVKGQPLYLSCEL--NKERDV 4937

Query: 278  EWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             W  +G+ ++    R++         L +      D G Y     N+     S+    V+
Sbjct: 4938 VWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVE 4997

Query: 338  EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFR--EDQRLLPCRKYEQIEEGTVR 395
              R    +P++D   +  G A+  C +        WF+  ++    P  K E + +G   
Sbjct: 4998 VIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHL 5057

Query: 396  RLIIHRLKADDDGIYLCEMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVET 452
             L I     +D   Y  E+ G+ R  A +T+   +  +LK +   + + E E+A    E 
Sbjct: 5058 YLKIKNAMPEDIAEYAVEIEGK-RYPAKLTLGEREVELLKPI-EDVTIYEKESASFDAEI 5115

Query: 453  LEAGVEGRWSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLR 509
             EA + G+W   GE L   P     + G    L L  V  + AGEV +   N+ TT +L 
Sbjct: 5116 SEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILT 5175

Query: 510  VKCVK--HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCF 567
            VK ++   + P   +     +  +   +LT        E   I+      + S D     
Sbjct: 5176 VKEIELDFAVPLKDVTVPERRQARFECVLT-------REANVIWSKGPDIIKSSDKFDII 5228

Query: 568  SIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQV 627
            +  K   + +       EG Y      V G   S  +   G        + ++ LED  V
Sbjct: 5229 ADGKKHILVINDSQFDDEGVYT---AEVEGKKTSARLFVTGIR-----LKFMSPLEDQTV 5280

Query: 628  YDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
             +GE A F  +LS   +   WF N  +L ++              I  +G  H+L +  V
Sbjct: 5281 KEGETATFVCELSHEKMHVVWFKNDAKLHTSRT----------VLISSEGKTHKLEMKEV 5330

Query: 687  KHQDSGALVGFSCPGVQDSAALTIQES-PVHILSPQDRVSLTFTTSERVVLTCELSRVDF 745
               D   +       +  +A L + E+ P   +   D+   T    + + L CE+S+ D 
Sbjct: 5331 TLDDISQIKA-QVKELSSTAQLKVLEADPYFTVKLHDK---TAVEKDEITLKCEVSK-DV 5385

Query: 746  PATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPP 805
            P  W+KDG+++  S    +K DG +  L + +A ++D GE+ C          VTV+   
Sbjct: 5386 PVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARL 5445

Query: 806  VHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLV 865
            + +  P   V V     E      E+   D   +W   GQ +  S    +  +G    L+
Sbjct: 5446 IKVEKPLYGVEV--FVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILI 5503

Query: 866  LPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRP 925
            L   Q    GE    A +  +   + + ++    + P   V V     +     CE+ R 
Sbjct: 5504 LHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKV--FEKDEAKFECEVSRE 5561

Query: 926  WAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTE 985
                RW K  +E+       L K+ T   +V+ +   ED  +Y+ E +D+  S  + +  
Sbjct: 5562 PKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEG 5621

Query: 986  PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCR 1045
              ++ + P  +VT  A   E  V   ELS ++  V+W+K+   +  + ++ ++ +G    
Sbjct: 5622 IRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 5679

Query: 1046 LVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEV 1105
            +       +D  +   +A   S+   +TV    E   +   +  D        V L+CE+
Sbjct: 5680 ITFKDLSIDDTSQIRVEAMGMSSEAKLTVL---EGDPYFTGKLQDYTGVEKDEVILQCEI 5736

Query: 1106 APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVI 1165
            + A + V+W+KDG E++ S    + A+G  R L L  A   D G+Y C+   +  +  + 
Sbjct: 5737 SKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLD 5796

Query: 1166 LAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEG 1225
            + +  ++   L      + V   E      E+S       W   G  + +    E+  EG
Sbjct: 5797 IEDREIK---LVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEG 5853

Query: 1226 PRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGG 1285
                L +        G      G    A ++  +  +   P RV+        V  T G 
Sbjct: 5854 KIHSLVLHNCRLDQTG------GVDFQAANVKSSAHLRVKP-RVIGLLRPLKDVTVTAGE 5906

Query: 1286 DLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQ 1345
                   LS    PV WY  G++L    +V     G    L ++  +  DAGE    A  
Sbjct: 5907 TATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD 5966

Query: 1346 DSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQV 1405
                  + V+EP  V+    L   TV EG  A   CEVS  +A V W +NG  +    + 
Sbjct: 5967 FKTHANLFVKEPP-VEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKY 6025

Query: 1406 EMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQD 1465
            E+  +G  R L +  C   D  T T  A    TS  L+V    + FLR L D++  E + 
Sbjct: 6026 EIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEM 6085

Query: 1466 VCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESH 1525
               E E  R  A   V+W + G  +    +  +   G +  L I+  +L D+  Y CE  
Sbjct: 6086 ARFECELSRENAK--VKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR 6143

Query: 1526 HDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKC 1585
              RT   L+V   +    + L ++ +SE  +     E+S+ G    W +G  ++    + 
Sbjct: 6144 TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRY 6203

Query: 1586 HIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT 1645
             I ++G +  LV+    L D+G  +    S R   ++ V E+    +  P +LE+ EG+ 
Sbjct: 6204 EILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEK 6263

Query: 1646 ATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTA 1705
            A F C +S+    V W++D   L    +  + A G +R+L ++     D GTY   VG A
Sbjct: 6264 AEFVCSISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAA 6323

Query: 1706 RAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVR 1765
            RA    LTV E+ + ++  L+    +E     F C V+      +W      +   ++  
Sbjct: 6324 RAA-AHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYI 6381

Query: 1766 IRQEGKKHILVLSELRAEDAGE-----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTV 1820
            I Q+   + L + +   +D           +    +S A L VE   L++   P ++   
Sbjct: 6382 ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIV-EPLKDIET 6440

Query: 1821 LVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC 1880
            +  +       V+R    + W + G E+   ++   R     H L I D    D+G Y  
Sbjct: 6441 MEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIV 6500

Query: 1881 QAGQDSTHTRLLV 1893
             AGQD +   LL+
Sbjct: 6501 TAGQDKSVAELLI 6513



 Score =  380 bits (975), Expect = e-105
 Identities = 317/1277 (24%), Positives = 523/1277 (40%), Gaps = 41/1277 (3%)

Query: 622  LEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRL 681
            L D    + ++     ++S  +   WF +GEE+  +           +Y I+  GL+  L
Sbjct: 5364 LHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSP----------KYSIKADGLRRIL 5413

Query: 682  ILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELS 741
             +     +D G  V   C   +  A +T++   + +  P   V +     E      ELS
Sbjct: 5414 KIKKADLKDKGEYV-CDCGTDKTKANVTVEARLIKVEKPLYGVEVF--VGETAHFEIELS 5470

Query: 742  RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTV 801
              D    W   GQ +  S    +  DG+KH LIL   ++  +GE   +     +   + V
Sbjct: 5471 EPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKV 5530

Query: 802  QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPH 861
            ++ P+  + P   V V     +     CEV RE    RW K  QE+   D   L  +G  
Sbjct: 5531 KELPLIFITPLSDVKV--FEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTK 5588

Query: 862  RRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCE 921
              +V+ +    D  ++   A D+     + I  +    + P   V   A   E  V T E
Sbjct: 5589 HSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDV--TAKEKESAVFTVE 5646

Query: 922  LCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTV 981
            L      V+W K+ + +  + ++ +Q E     +    + ++D+ +   E    S+   +
Sbjct: 5647 LSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 5706

Query: 982  TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
            TV E          + T   V  + V+L CE+S+ DAPV+W+KDG E++ S+  V++ DG
Sbjct: 5707 TVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADG 5764

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             +  L+L  A   D G++ CD G D     + +     ++V P   S+++      R E 
Sbjct: 5765 KKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPL-HSVEVMETETARFET 5823

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
              E++       W   G  +  +   ++  EG   +L L + + +  G    +  +   +
Sbjct: 5824 --EISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSS 5881

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLEL 1221
             + +  +P V  + L      + V  GE     CELS    PV W   G+ ++  + +  
Sbjct: 5882 AH-LRVKPRV--IGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVP 5938

Query: 1222 HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRS 1281
             +EG    L ++      AG     +       +L     V EPPV    P   QT    
Sbjct: 5939 RSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----VKEPPVEFTKPLEDQT---V 5991

Query: 1282 TPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
              G    L   +S     V+W+K+G  +    + ++   G  + L +      D   Y C
Sbjct: 5992 EEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC 6051

Query: 1342 DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP 1401
            DA        ++V  P  V+ +  LT L V E + A F CE+S  +A V W ++GA +  
Sbjct: 6052 DAKDFKTSCNLNVVPPH-VEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKK 6110

Query: 1402 GPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAE 1461
            G + ++   G+ RIL +  C L D    +    +  TS  L V E E +F + L ++   
Sbjct: 6111 GKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVS 6170

Query: 1462 EGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYG 1521
            E   + L  E  + GA   V W +G + +    R  +  +G    L I    L D G Y 
Sbjct: 6171 ETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYN 6228

Query: 1522 CESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
            C     RT  ++ V       +   +++ I EG  A F   +S+E    +W R    L  
Sbjct: 6229 CRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLES 6288

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
            G K  + +DG +  LV+    L D G       + R AA L V E  + IV    D  V 
Sbjct: 6289 GDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK 6347

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA 1701
            E     F CE++   A   W ++  A+  S +  +        L++R     D   Y+ +
Sbjct: 6348 EQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVS 6407

Query: 1702 VGTARAGPVR----LTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRP 1757
            +   R   V+    L V E  + ++  L+ +   E    TF C V+ +  T +W   G  
Sbjct: 6408 LTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEE 6467

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            +    RV  R +  KH+L + +    D GE    AG  +S+A L +   P +   H   +
Sbjct: 6468 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHL-ED 6526

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
            +TV     AV    +SR   +V W R G E+  G KY+    G  H L+I D R +D+  
Sbjct: 6527 QTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECE 6586

Query: 1878 YCCQAGQDSTHTRLLVE 1894
            Y C      +  RL VE
Sbjct: 6587 YACGVEDRKSRARLFVE 6603



 Score =  371 bits (952), Expect = e-102
 Identities = 397/1661 (23%), Positives = 670/1661 (40%), Gaps = 102/1661 (6%)

Query: 276  EIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKD-RGLYVCAARNSAGQTLSAVQL 334
            E+ W++E + L+P   +         + L +     +D +G YVC A N +G+T ++ +L
Sbjct: 4463 EVNWYFENK-LVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKL 4521

Query: 335  H-VKEPRLRFTRPLQDVEGREHGIAVLECKV---PNSRIPTAWFREDQRLLPCRKYEQIE 390
              VK       R ++ +E     +A   C++   PN R    WF+  + +    K     
Sbjct: 4522 TVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRF--QWFKAGREIYESDKCSIRS 4579

Query: 391  EGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVANVTVKGP-----ILKRLPRKLDVLE 442
               +  L I R +  D G Y C+     G V   A +TV  P     + K LP +    E
Sbjct: 4580 SKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPERKP--E 4637

Query: 443  GENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLP-GVTREDAGEVTFSLGN 501
             +  V+L   L         R  EE P +       +    +P     +   EV      
Sbjct: 4638 PKEEVVLKSVLR-------KRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVT 4690

Query: 502  SRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE-TPFIYRLERQEVGS 560
             R   +     V    P  P+ A   K      + T KPP   PE TP    +    VG 
Sbjct: 4691 KRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGK 4750

Query: 561  EDWIQCFSIEKA---GAVEVPGDCVPSEGDYRFRICTVSGHGRSP--HVVFHGSAHLVPT 615
            +   +    E A   G ++      PS  +   R       G  P     F      VP 
Sbjct: 4751 KAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAVP- 4809

Query: 616  ARLVAGLEDV----QVYDGEDAVFS--LDLSTIIQGTWFLNGEELKSNEPEGQVEPGALR 669
             + V  ++D+      + G  A+F   +  ST I  TW  +G  ++ +           +
Sbjct: 4810 LKFVKEIKDIILTESEFVGSSAIFECLVSPSTAIT-TWMKDGSNIRESP----------K 4858

Query: 670  YRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD---SAALTIQESPVHILSPQDRVSL 726
            +R    G   +L +  V+  D+G        G ++   +A L ++E PV  +   +   +
Sbjct: 4859 HRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEE-EV 4917

Query: 727  TFTTSERVVLTCELSRVDFPATWYKDGQ-KVEESELLVVKMDGRKHRLILPEAKVQDSGE 785
            T    + + L+CEL++ +    W KDG+  VE+   +V  + G    L + +A   D+G 
Sbjct: 4918 TVVKGQPLYLSCELNK-ERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGT 4976

Query: 786  FECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECV------MLACEVDREDAPVR 839
            +    E  +     +     V +V+      V  I  + V      + AC++ ++   ++
Sbjct: 4977 YTVTVENANNLECSSC----VKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIK 5032

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+K   E+  E +D   +  +G H  L +    P D  E+      +     +T+ +   
Sbjct: 5033 WFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREV 5092

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             ++ P   V +     E      E+       +W   GE +  SP   ++ E   R L L
Sbjct: 5093 ELLKPIEDVTI--YEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTL 5150

Query: 958  PAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTL---IAVTLECVVLMCELS 1014
              V+L+ +GE L +  +   +  +TV E  +    P  +VT+        ECV     L+
Sbjct: 5151 HKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECV-----LT 5205

Query: 1015 REDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV 1074
            RE A V W K    ++ S+   +  DG +  LV+  +Q +D G +  +         + V
Sbjct: 5206 RE-ANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFV 5264

Query: 1075 TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGP 1134
            T    + + P     D            CE++     V W+K+  ++  S  + + +EG 
Sbjct: 5265 TGIRLKFMSPLE---DQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGK 5321

Query: 1135 TRTLTLPHAQPEDAGEYVCETRHEAIT--FNVILAEPPVQFLALETTPSPLCVAPGEPVV 1192
            T  L +     +D  +   + +  + T    V+ A+P       + T         + + 
Sbjct: 5322 THKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKT-----AVEKDEIT 5376

Query: 1193 LSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPG 1252
            L CE+S+   PV W  +G  +       + A+G RR+L I+ A     G Y C  G    
Sbjct: 5377 LKCEVSK-DVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGT--D 5433

Query: 1253 APSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQ 1312
                + TV+      R++  E     V    G      + LS P    +W   G+ L + 
Sbjct: 5434 KTKANVTVE-----ARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTAS 5488

Query: 1313 GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVH 1372
               ++ + G + +L +   + G  GE    A        + V+E  L+  ++ L+ + V 
Sbjct: 5489 PDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLI-FITPLSDVKVF 5547

Query: 1373 EGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
            E D+A F CEVS       WL+    +T   + E+ ++G+   + ++     D       
Sbjct: 5548 EKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFE 5607

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
            A    TS +L +    L FL  L+DV A+E +     VE         V+W +  Q L  
Sbjct: 5608 AEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDNI--RVKWFKNDQRLHT 5665

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTIS 1552
               +SM  +G  H +    + + D      E+    + A+L+V          L+D T  
Sbjct: 5666 TRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYTGV 5725

Query: 1553 EGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFT 1612
            E      Q E+S+     +W + G ++ P     I +DG +  L+L     +D G  +  
Sbjct: 5726 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 5785

Query: 1613 ADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSP 1672
              + + + +L + +  + +VR  H +EV E +TA FE E+S+      W+  G AL  +P
Sbjct: 5786 CGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTP 5845

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSARE 1732
               ++  G    L L  C     G         ++    L V+ R + +L  L+ V+   
Sbjct: 5846 DCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSS-AHLRVKPRVIGLLRPLKDVTVTA 5904

Query: 1733 GDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA 1792
            G+ ATF+C +S  +    W L G+ L P  +V  R EGK H L L +++ EDAGEV+  A
Sbjct: 5905 GETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTA 5964

Query: 1793 GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGD 1852
               ++ A L V+  P++  + P  ++TV  G  AVLE  VSR    V W + G E+    
Sbjct: 5965 KDFKTHANLFVKEPPVEFTK-PLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSK 6023

Query: 1853 KYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            KYE+ + G    LVIHD  PED  TY C A    T   L V
Sbjct: 6024 KYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV 6064



 Score =  349 bits (896), Expect = 1e-95
 Identities = 341/1251 (27%), Positives = 528/1251 (42%), Gaps = 98/1251 (7%)

Query: 701  GVQDSAALTIQESPVHILS---PQDRVSLTFTTSER---VVLTCELSRVDFPATWYKDGQ 754
            G ++ A + IQE+   ++    P     L  T SE    V LT  ++       WY + +
Sbjct: 4413 GTEEVATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSITNAK-EVNWYFENK 4471

Query: 755  KVEESELLVVKMDGRKHRLILPEAKVQD-SGEFECRT------EGVSAFFGVTVQDPPV- 806
             V   E      D   + L++ +   +D  GE+ C           SA   V  +  PV 
Sbjct: 4472 LVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVI 4531

Query: 807  -HIVDPREHVFVHAITSECVMLACEVDREDAP---VRWYKDGQEVEESDFVVLENEGPHR 862
               ++P E    H          CE+  + AP    +W+K G+E+ ESD   + +     
Sbjct: 4532 KRKIEPLEVALGHL-----AKFTCEI--QSAPNVRFQWFKAGREIYESDKCSIRSSKYIS 4584

Query: 863  RLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLER------- 915
             L +  TQ  D GE+ C A +E    + T T     +  P G+  V  +  ER       
Sbjct: 4585 SLEILRTQVVDCGEYTCKASNEYGSVSCTATLT---VTVPGGEKKVRKLLPERKPEPKEE 4641

Query: 916  VVLTCELCR------PWAEVRWTKDGE-------------EVVESPALLLQK----EDTV 952
            VVL   L +      P  E +  +  +             E VE P +  ++    E T 
Sbjct: 4642 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTK 4701

Query: 953  RRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
               + PA+ L  + E   + + E  +      EP    I     V ++    E      E
Sbjct: 4702 VPEIKPAIPLP-APEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEE 4760

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTV 1072
             ++   P++    G+  +    +  ER   R         P  GGE       D A FT 
Sbjct: 4761 AAKPKGPIK----GVPKKTPSPIEAERRKLR---------PGSGGE----KPPDEAPFTY 4803

Query: 1073 TVTAPPERIVHPAARSLDLHFGAPGRVEL-RCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
             + A P + V      +       G   +  C V+P+ +   W KDG  +  S   +  A
Sbjct: 4804 QLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIA 4863

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETR----HEAITFNVILAEPPVQFLALETTPSPLCVAP 1187
            +G  R L +   Q  DAGEY C  R     +  T  +++ E PV+F+  +T    + V  
Sbjct: 4864 DGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFV--KTLEEEVTVVK 4921

Query: 1188 GEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAE-GPRRVLCIQAAGPAHAGLYTCQ 1246
            G+P+ LSCEL++    VVW  +G+ V E  G  +    G  R L I  A    AG YT  
Sbjct: 4922 GQPLYLSCELNKE-RDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVT 4980

Query: 1247 SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
               A      S  V+V E     +        V+  P G       ++     ++W+K  
Sbjct: 4981 VENANNL-ECSSCVKVVEVIRDWLVKPIRDQHVK--PKGTAIFACDIAKDTPNIKWFKGY 5037

Query: 1307 ERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVS 1364
            + + ++   + ++ + G    L+++ A   D  EY  +         +++ E   V+L+ 
Sbjct: 5038 DEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGERE-VELLK 5096

Query: 1365 ELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             +  +T++E + A+F  E+S  D    W   G ++ P P  E+   G  R LTL   +L 
Sbjct: 5097 PIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLD 5156

Query: 1425 DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWV 1484
             AG V  +A +  T+A L V+E EL F   L+DV   E +    E    R      V W 
Sbjct: 5157 QAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTR---EANVIWS 5213

Query: 1485 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            +G   +    +  +  DG  H L I+     D+G Y  E    +T ARL V   +L+ + 
Sbjct: 5214 KGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIRLKFMS 5273

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLA 1604
            PLED T+ EG +ATF  ELS E +   W +   +L+      I S+G  H+L +  + L 
Sbjct: 5274 PLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLD 5333

Query: 1605 DSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKD 1664
            D   +      L   A+L V E         HD    E D  T +CE+S+ +  V W KD
Sbjct: 5334 DISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVP-VKWFKD 5392

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
            G  + PSP+  ++A G RR+L++++    D G Y C  GT +     +TV  R + V   
Sbjct: 5393 GEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKT-KANVTVEARLIKVEKP 5451

Query: 1725 LRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAED 1784
            L  V    G+ A FE  +SE +  G+W+L G+PL       I ++GKKHIL+L   +   
Sbjct: 5452 LYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGM 5511

Query: 1785 AGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLRE 1844
             GEV FQA  A+S A L+V+ LPL     P  +  V     A  E  VSR      WL+ 
Sbjct: 5512 TGEVSFQAANAKSAANLKVKELPLIFIT-PLSDVKVFEKDEAKFECEVSREPKTFRWLKG 5570

Query: 1845 GAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
              E+   D++E+   G  HS+VI     ED+  Y  +A    T  +L++EG
Sbjct: 5571 TQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEG 5621



 Score =  315 bits (807), Expect = 3e-85
 Identities = 253/996 (25%), Positives = 429/996 (43%), Gaps = 47/996 (4%)

Query: 917  VLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI---- 972
            +  C +    A   W KDG  + ESP      +   R+L +  VQL D+GEY C +    
Sbjct: 4832 IFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGN 4891

Query: 973  DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDG-LEVEE 1031
             +++++  + V E PVR +   +E   + V  + + L CEL++E   V W KDG + VE+
Sbjct: 4892 KEKTSTAKLVVEELPVRFVKTLEEEVTV-VKGQPLYLSCELNKE-RDVVWRKDGKIVVEK 4949

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGD----DSAFFTVTVTAPPERIVHPAAR 1087
               +V    G    L +  A   D G +     +    + +     V    + +V P   
Sbjct: 4950 PGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIR- 5008

Query: 1088 SLDLHFGAPGRVELRCEVAPAGSQVRWYK--DGLEVEASDALQLGAEGPTRTLTLPHAQP 1145
              D H    G     C++A     ++W+K  D +  E +D  ++  +G    L + +A P
Sbjct: 5009 --DQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMP 5066

Query: 1146 EDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV 1205
            ED  EY  E   +     + L E  V+ L        + +   E      E+S A  P  
Sbjct: 5067 EDIAEYAVEIEGKRYPAKLTLGEREVELL---KPIEDVTIYEKESASFDAEISEADIPGQ 5123

Query: 1206 WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG--LYTCQSGAAPGAPSL-SFTVQV 1262
            W   G  ++     E+ AEG +R L +       AG  LY   +       ++    +  
Sbjct: 5124 WKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDF 5183

Query: 1263 AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
            A P   V  PE  Q R       +  ++           W K  + + S  +  +   G 
Sbjct: 5184 AVPLKDVTVPERRQARFECVLTREANVI-----------WSKGPDIIKSSDKFDIIADGK 5232

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
            + +L +  ++  D G Y  +       +R+F+  +     +K +S L   TV EG+ ATF
Sbjct: 5233 KHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGETATF 5288

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATS 1439
             CE+S     V W +N A +     V ++  G +  L ++   L D   +  +    +++
Sbjct: 5289 VCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSST 5348

Query: 1440 ARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMA 1499
            A+L V E +  F  +L D  A E  ++ L+ E   V     V+W + G+ +    + S+ 
Sbjct: 5349 AQLKVLEADPYFTVKLHDKTAVEKDEITLKCE---VSKDVPVKWFKDGEEIVPSPKYSIK 5405

Query: 1500 QDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
             DG    L I    L D+G Y C+   D+T A ++V  R ++V +PL  V +  G +A F
Sbjct: 5406 ADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHF 5465

Query: 1560 QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
            ++ELS+  V G+W   G  L   P C I  DG +H L+L+   L  +G VSF A + + A
Sbjct: 5466 EIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA 5525

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
            A L V+E+P+  +    D++V E D A FECE+S+      W K    +T   R  L   
Sbjct: 5526 ANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKD 5585

Query: 1680 GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
            GT+  + ++     D   Y            +L +    +  L+ L+ V+A+E + A F 
Sbjct: 5586 GTKHSMVIKSAAFEDEAKYMFEAEDKHTSG-KLIIEGIRLKFLTPLKDVTAKEKESAVFT 5644

Query: 1740 CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA-GPAQSL 1798
              +S      +W    + L     V ++ EGK H +   +L  +D  ++R +A G +   
Sbjct: 5645 VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 5704

Query: 1799 ALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRS 1858
             L  +E  P    +   ++ T +     +L+  +S++   V W ++G E+ P     +++
Sbjct: 5705 KLTVLEGDPYFTGK--LQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKA 5762

Query: 1859 HGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             G    L++      D G Y C  G D T  +L +E
Sbjct: 5763 DGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIE 5798



 Score =  291 bits (745), Expect = 4e-78
 Identities = 315/1294 (24%), Positives = 508/1294 (39%), Gaps = 122/1294 (9%)

Query: 674  QKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA-LTIQESPVHILSPQDRVSLTFTTSE 732
            +KGLQ    L  + H+  GAL G +    +     + +   PV +L             E
Sbjct: 1764 RKGLQRIEELERMAHE--GALTGVTTDQKEKQKPDIVLYPEPVRVLE-----------GE 1810

Query: 733  RVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE 791
                 C ++    P   WY +GQ + +S+   V+ DG  H L + + K  D+GE +   E
Sbjct: 1811 TARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGEVKVTAE 1869

Query: 792  GVSAFFGVTVQDPPVHIV-------------DPREHVFVHAITSECVMLACEVDREDAPV 838
                  GV      + I              +PR    VH    E   L  EV + D PV
Sbjct: 1870 NPE---GVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVH----EPGKLQFEVQKVDRPV 1922

Query: 839  -----------------RWYKDGQEVEE--SDFVVLENEGPHRRLV---LPATQPSDG-G 875
                                K  +E EE  S F     EG +  +    L + +  +   
Sbjct: 1923 DTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYE 1982

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL------------- 922
            E      DE  ++T  +T+     +   GK+ +   + +++ L+  +             
Sbjct: 1983 ELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQT 2042

Query: 923  --------------CRPWAEVRWTKDGEEVVESPALLLQ-KEDTVRRLVLPAVQLEDSGE 967
                           +P  E  W K+G ++  S  +     ED V  LV+  V  EDS  
Sbjct: 2043 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSAS 2102

Query: 968  YLCE---IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM-CELSREDAPVRWY 1023
             + +   I  E++S    + +    I + ++   ++A   + +    CE S     V+WY
Sbjct: 2103 IMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWY 2162

Query: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVH 1083
            KDG+EV E +   +  D     L +      D  ++ C   +D    T         +V 
Sbjct: 2163 KDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVE 2222

Query: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHA 1143
                  D+        EL C V+P   + +WY + +E++++    + +    + LT+   
Sbjct: 2223 FVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDV 2282

Query: 1144 QPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP 1203
              ED GEY      +  T  + +   P+  L      S   V  G+ V L  ++S     
Sbjct: 2283 TKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQ---GLSDQKVCEGDIVQLEVKVSLESVE 2339

Query: 1204 VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVA 1263
             VW  +G+ VQ  + + +  +    +L I+      AG Y+    A      LS + +V+
Sbjct: 2340 GVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPAL----GLSTSGRVS 2395

Query: 1264 EPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG-GPVRWYKDGERLASQGRVQLEQAGA 1322
               V V+ P      V    G    L   +S P    V+WY + E++    RVQ    G 
Sbjct: 2396 VYSVDVITP---LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT 2452

Query: 1323 RQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE 1382
            +Q L +    + D G Y     +      +SVE+   +K++  L  LT  E  +  F  E
Sbjct: 2453 KQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK---IKIIRGLRDLTCTETQNVVFEVE 2509

Query: 1383 VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARL 1442
            +S    DV W      + P  + ++  +G    LT+      D G  T  AG   TS +L
Sbjct: 2510 LSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKL 2569

Query: 1443 HVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG 1502
             V    +   + L D    E Q+   E E     + G   W+R G+ LP  + +    DG
Sbjct: 2570 TVAGGAIS--KPLTDQTVAESQEAVFECEVANPDSKG--EWLRDGKHLPLTNNIRSESDG 2625

Query: 1503 HIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE 1562
            H  RL I    L D G Y  +    +T A+L V    +++ + L+++T++E   A F +E
Sbjct: 2626 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEA--VKIKKTLKNLTVTETQDAVFTVE 2683

Query: 1563 LSQEGVTG-EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAAR 1621
            L+   V G +W + GV L    K  I   G  + L +    + D     F    L  +AR
Sbjct: 2684 LTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASAR 2743

Query: 1622 LIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGT 1681
            L V  V   I++ P D+   E  T  FE  +S     V W      + PS + RL +   
Sbjct: 2744 LHVETVK--IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERK 2801

Query: 1682 RRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECT 1741
               L L+   PSDAG Y+  VG       +  +   T+ +   ++++   E   A+FEC 
Sbjct: 2802 VHKLMLQNISPSDAGEYTAVVGQLEC---KAKLFVETLHITKTMKNIEVPETKTASFECE 2858

Query: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALL 1801
            VS       W   G  +    + +I  +GK H L++     ED+ E  F  G  Q  A L
Sbjct: 2859 VSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATL 2918

Query: 1802 EVEALPL-QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860
             V  + +  M +    E+   +      EVTV+  G    WL+ G E+   DK +MR+  
Sbjct: 2919 TVTPIMITSMLKDINAEEKDTI----TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKK 2974

Query: 1861 PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             THSL I +V   D   Y   AG+ ++   L VE
Sbjct: 2975 LTHSLNIRNVHFGDAADYTFVAGKATSTATLYVE 3008



 Score =  283 bits (723), Expect = 1e-75
 Identities = 253/1072 (23%), Positives = 449/1072 (41%), Gaps = 36/1072 (3%)

Query: 831  VDREDAPVRWYKDGQEVEESDFVVLE-NEGPHRRLVLPATQPSDGGEFQC----VAGDEC 885
            V + D    WYK+G ++E SD +     E     LV+      D          +AG+  
Sbjct: 2056 VGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETS 2115

Query: 886  AYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945
            ++  + +            +  VA  +       CE   P+ +V+W KDG EV E     
Sbjct: 2116 SHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYR 2175

Query: 946  LQKEDTVRRLVLPAVQLEDSGEYLCE-IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTL 1004
            +  +  V  L +  +   D+ +Y C  ++DE+   T  +      + + ++   +     
Sbjct: 2176 MHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPES 2235

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
                L C +S E+   +WY + +E++ +    +     R  L +     ED GE+     
Sbjct: 2236 YSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVID 2295

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
                   + +   P  I+   +   D        V+L  +V+    +  W KDG EV+ S
Sbjct: 2296 GKKTTCKLKMKPRPIAILQGLS---DQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPS 2352

Query: 1125 DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            D + +  +  +  L +     EDAG Y        ++ +  ++   V  +   T    + 
Sbjct: 2353 DRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVI---TPLKDVN 2409

Query: 1185 VAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLY 1243
            V  G   VL C++S      V W  N   ++  + ++   +G ++ L I     +  G Y
Sbjct: 2410 VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2469

Query: 1244 TCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWY 1303
                G      +LS         V  +        +  T   ++   V LS  G  V W 
Sbjct: 2470 KLIVGRVETNCNLS---------VEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLV 1363
               + +    + ++E  G    L V      D G+Y   A ++     ++V    + K  
Sbjct: 2521 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISK-- 2578

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQL 1423
              LT  TV E  +A F CEV+ PD+   WLR+G  +     +    +G  R L +   +L
Sbjct: 2579 -PLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKL 2637

Query: 1424 GDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRW 1483
             D G  T +  ++ TSA+L V   ++   + L+++   E QD    VE       G V+W
Sbjct: 2638 DDIGEYTYKVATSKTSAKLKVEAVKIK--KTLKNLTVTETQDAVFTVELTHPNVKG-VQW 2694

Query: 1484 VRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVL 1543
            ++ G  L  + + +++  G I+ L I    + D+  YG         ARL V    ++++
Sbjct: 2695 IKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET--VKII 2752

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            +  +DVT  E  +  F++ +S + V  +W    V++ P  K  + S+   H+L+L  +  
Sbjct: 2753 KKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISP 2812

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
            +D+G  +     L C A+L V  + +T  +   ++EV E  TA+FECE+S       W K
Sbjct: 2813 SDAGEYTAVVGQLECKAKLFVETLHIT--KTMKNIEVPETKTASFECEVSHFNVPSMWLK 2870

Query: 1664 DGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLS 1723
            +G  +  S + ++   G    L +      D+  Y+   G  +   V  T+    + + S
Sbjct: 2871 NGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQ---VSATLTVTPIMITS 2927

Query: 1724 ELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
             L+ ++A E D  TFE TV+    + +W   G  ++   + ++R +   H L +  +   
Sbjct: 2928 MLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFG 2987

Query: 1784 DAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLR 1843
            DA +  F AG A S A L VEA  ++  +H  ++  VL  +RA+ E  VS     V W++
Sbjct: 2988 DAADYTFVAGKATSTATLYVEARHIEFRKHI-KDIKVLEKKRAMFECEVSEPDITVQWMK 3046

Query: 1844 EGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
            +  EL   D+ +++     H L+I   R  D G Y   AG + +  +L VEG
Sbjct: 3047 DDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEG 3098



 Score =  263 bits (671), Expect = 2e-69
 Identities = 370/1671 (22%), Positives = 649/1671 (38%), Gaps = 200/1671 (11%)

Query: 233  PPADPDEAPAPVVEPLKCAPKTF------WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            P   PD+     + P   APK F       V +G  A FR  V+GKP+PE EW+  G  +
Sbjct: 2016 PTFKPDKIE---LSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI 2072

Query: 287  LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRL-RFTR 345
                R   Y   D    L +    A+D    +  A N AG+T S   L V+  +L  FT+
Sbjct: 2073 ERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2132

Query: 346  PLQDVEGREHG-IAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKA 404
             LQDV  +E   +A  EC+     +   W+++   +    KY    +  V  L I  +  
Sbjct: 2133 ELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDT 2192

Query: 405  DDDGIYLCEM--RGRVRTVANVTVKGPILKRLP--RKLDVLEGENAVLLVETLEAGVEGR 460
             D   Y C +     V+T A + V+G +++ +   + ++V E  +  L        +EG+
Sbjct: 2193 SDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGK 2252

Query: 461  WSRDGEEL----PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
            W  +  EL         S  G  + L +  VT+ED GE +F +   +TT  L++K     
Sbjct: 2253 WYHNDVELKSNGKYTITSRRGRQN-LTVKDVTKEDQGEYSFVIDGKKTTCKLKMK----- 2306

Query: 517  PPGPPILAEMFKGHK----NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKA 572
             P P  + +     K    + V L  K    + E   ++  + QEV   D +     +++
Sbjct: 2307 -PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEG--VWMKDGQEVQPSDRVHIVIDKQS 2363

Query: 573  GAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGED 632
              + +        G+Y F I  + G   S  V  +    + P       L+DV V +G  
Sbjct: 2364 HMLLIEDMTKEDAGNYSFTIPAL-GLSTSGRVSVYSVDVITP-------LKDVNVIEGTK 2415

Query: 633  AVFSLDLST--IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQD 690
            AV    +S   +    W+LN E++K ++          R +   KG + RL+++     D
Sbjct: 2416 AVLECKVSVPDVTSVKWYLNDEQIKPDD----------RVQAIVKGTKQRLVINRTHASD 2465

Query: 691  SG---ALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA 747
             G    +VG     V+ +  L++++  + I   +D   LT T ++ VV   ELS      
Sbjct: 2466 EGPYKLIVG----RVETNCNLSVEKIKI-IRGLRD---LTCTETQNVVFEVELSHSGIDV 2517

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF-----ECRTEGVSAFFGVTVQ 802
             W    ++++ S    ++  G+ ++L +      D G++     E  T G     G  + 
Sbjct: 2518 LWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAIS 2577

Query: 803  DPPVH--IVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGP 860
             P     + + +E VF            CEV   D+   W +DG+ +  ++ +  E++G 
Sbjct: 2578 KPLTDQTVAESQEAVF-----------ECEVANPDSKGEWLRDGKHLPLTNNIRSESDGH 2626

Query: 861  HRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKV-----YVAAVRLER 915
             RRL++ AT+  D GE+          + V  +  S+ +   + K+      +     + 
Sbjct: 2627 KRRLIIAATKLDDIGEYT---------YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2677

Query: 916  VVLTCELCRPWAE-VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V T EL  P  + V+W K+G  +  +    +  + T+  L +    + D   Y   +  
Sbjct: 2678 AVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGR 2737

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEA 1034
              AS  + V    V+II    +VT  A+    V     +S +  PV+W+   +E++ S+ 
Sbjct: 2738 LGASARLHV--ETVKIIKKPKDVT--ALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDK 2793

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGD---DSAFF--TVTVTAPPERIVHPAARSL 1089
              L  +    +L+L    P D GE+    G     +  F  T+ +T   + I  P  ++ 
Sbjct: 2794 HRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT- 2852

Query: 1090 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
                         CEV+       W K+G+E+E S+  ++  +G    L + +   ED+ 
Sbjct: 2853 ---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSA 2903

Query: 1150 EY--VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWS 1207
            EY  VC     + T  V     P+   ++      +     + +     ++  G    W 
Sbjct: 2904 EYTFVCGNDQVSATLTV----TPIMITSM---LKDINAEEKDTITFEVTVNYEGISYKWL 2956

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE--- 1264
             NG  ++  +  ++  +     L I+      A  YT  +G A    +L    +  E   
Sbjct: 2957 KNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRK 3016

Query: 1265 --PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
                ++V+  + A                 +S P   V+W KD + L    R+++++   
Sbjct: 3017 HIKDIKVLEKKRAM------------FECEVSEPDITVQWMKDDQELQITDRIKIQKEKY 3064

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
               L +   R  DAG+Y   A      +++F+    E   V++ S    + V E   A  
Sbjct: 3065 VHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV----EGRDVRIRSIKKEVQVIEKQRAVV 3120

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRI--LTLRGCQLGDAGTVTLRAGSTA 1437
              EV+  D D  W ++G  +    Q         RI  + +   +  DAG  T  AG   
Sbjct: 3121 EFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNR 3180

Query: 1438 TSARLHVRETE-LLFLRRLQDVRAEEGQDV-CLEVETGRVGAAGAVRWVRGGQPLPHDSR 1495
            +S  L+V   E    L+ LQ V  + G+      V +GR      + W +  Q L    +
Sbjct: 3181 SSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGR--PQPKISWYKEEQLLSTGFK 3238

Query: 1496 LSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RTLARLSVRPRQL----------- 1540
                 DG  + L +      D   Y CE+ +D     T A LSV   ++           
Sbjct: 3239 CKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP 3298

Query: 1541 -RVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
              ++ PL+D   SEG  A FQ  +S   +   W     ++ P     +      ++L + 
Sbjct: 3299 PAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIA 3358

Query: 1600 GLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADV 1659
                 D G  +F A +   A   +     +++     D + +  D    E   SQA+AD 
Sbjct: 3359 EAYPEDEGTYTFVASN---AVGQVSSTANLSLEVQALDRQSSGKDVR--ESAKSQAVADS 3413

Query: 1660 TWEKDGNALTPSPRLRLQALGTRRLLQL-RRCGPSDAGTYSCAVGTARAGPVRLT-VRER 1717
            ++ K+ + ++       Q       +Q+      S   T +    T       L+ + E 
Sbjct: 3414 SFTKEESKISQKEIKSFQGSSYEYEVQVFESVSQSSIHTAASVQDTQLCHTASLSQIAES 3473

Query: 1718 T--------------VAVLSELRSVSAREGDGATFECTVSE---VETTGRWELGGRPLRP 1760
            T                +   L+ V+ + GD A F C + +   ++ T  W   G  +  
Sbjct: 3474 TELSKECAKESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVT--WTHEGAKIEE 3531

Query: 1761 GARVRIRQEGKKHILVLSELRAEDAG----EVRFQAGPAQSLALLEVEALP 1807
              R++  Q G    L +  ++  D G     V    G   + A+L VE  P
Sbjct: 3532 SERLKQSQNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGAP 3582



 Score =  257 bits (657), Expect = 7e-68
 Identities = 273/1217 (22%), Positives = 467/1217 (38%), Gaps = 48/1217 (3%)

Query: 681  LILHAVKHQDSGALV--GFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVV-LT 737
            L++  V  +DS +++    +  G   S A  + ++   I   Q+   +     + +    
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFE 2149

Query: 738  CELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC---RTEGVS 794
            CE S       WYKDG +V E +   +  D + H L +      D+ ++ C     E V 
Sbjct: 2150 CETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVK 2209

Query: 795  AFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVV 854
                + V+   V  V   + + V    S    L C V  E+   +WY +  E++ +    
Sbjct: 2210 TTAKLIVEGAVVEFVKELQDIEVPESYSG--ELECIVSPENIEGKWYHNDVELKSNGKYT 2267

Query: 855  LENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLE 914
            + +    + L +      D GE+  V   +    T  +      I    G         +
Sbjct: 2268 ITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKT--TCKLKMKPRPIAILQGLSDQKVCEGD 2325

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V L  ++     E  W KDG+EV  S  + +  +     L++  +  ED+G Y   I  
Sbjct: 2326 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPA 2385

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESE 1033
               S +  V+   V +I P  +V +I  T    VL C++S  D   V+WY +  +++  +
Sbjct: 2386 LGLSTSGRVSVYSVDVITPLKDVNVIEGTK--AVLECKVSVPDVTSVKWYLNDEQIKPDD 2443

Query: 1034 ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSL-DLH 1092
             +     G + RLV+      D G +    G       ++V    E+I     R L DL 
Sbjct: 2444 RVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSV----EKI--KIIRGLRDLT 2497

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                  V    E++ +G  V W     E++ S   ++ A G    LT+ +   +D G+Y 
Sbjct: 2498 CTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYT 2557

Query: 1153 CETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRP 1212
                    +  + +A   +     + T     VA  +  V  CE++   +   W  +G+ 
Sbjct: 2558 FYAGENMTSGKLTVAGGAISKPLTDQT-----VAESQEAVFECEVANPDSKGEWLRDGKH 2612

Query: 1213 VQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
            +     +   ++G +R L I A      G YT +   +  +  L          V  V  
Sbjct: 2613 LPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLK---------VEAVKI 2663

Query: 1273 EAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGA 1331
            +     +  T   D    V L+ P    V+W K+G  L S  +  +   G    LR++  
Sbjct: 2664 KKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNC 2723

Query: 1332 RSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVT 1391
               D   Y     +      + VE   ++K   ++T L   E     F   VS     V 
Sbjct: 2724 AIVDESVYGFRLGRLGASARLHVETVKIIKKPKDVTAL---ENATVAFEVSVSHDTVPVK 2780

Query: 1392 WLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLF 1451
            W      + P  +  +        L L+     DAG  T   G     A+L V    +  
Sbjct: 2781 WFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHIT- 2839

Query: 1452 LRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHG 1511
             + ++++   E +    E E           W++ G  +    +  +   G +H+L I  
Sbjct: 2840 -KTMKNIEVPETKTASFECEVSHFNVPSM--WLKNGVEIEMSEKFKIVVQGKLHQLIIMN 2896

Query: 1512 VILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE 1571
                D   Y     +D+  A L+V P  + +   L+D+   E  + TF++ ++ EG++ +
Sbjct: 2897 TSTEDSAEYTFVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITFEVTVNYEGISYK 2954

Query: 1572 WARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTI 1631
            W + GV++    KC + +    H L +  +   D+   +F A      A L V    +  
Sbjct: 2955 WLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEF 3014

Query: 1632 VRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCG 1691
             +   D++V E   A FECE+S+    V W KD   L  + R+++Q       L +    
Sbjct: 3015 RKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTR 3074

Query: 1692 PSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRW 1751
             SDAG Y+   G       +L V  R V + S  + V   E   A  E  V+E +    W
Sbjct: 3075 MSDAGKYTVVAG-GNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHW 3133

Query: 1752 ELGGRPLRPGARVRIRQ--EGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
               G  +    + R +   E + H + +SE R  DAGE  F AG  +S   L V A    
Sbjct: 3134 YKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPP 3193

Query: 1810 MCRHPPREKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIH 1868
                  +  TV  G+ A     +S R    + W +E   L  G K +    G  ++L++ 
Sbjct: 3194 QVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLI 3253

Query: 1869 DVRPEDQGTYCCQAGQD 1885
            +  PED   Y C+A  D
Sbjct: 3254 EAFPEDAAVYTCEAKND 3270



 Score =  254 bits (650), Expect = 4e-67
 Identities = 296/1330 (22%), Positives = 527/1330 (39%), Gaps = 109/1330 (8%)

Query: 612  LVPTARLVAGLEDVQ--VYDGEDAVFSLDLST---IIQGTWFLNGEELKSNEPEGQVEPG 666
            LV   +L+   +++Q  V   +D + + +  T    ++  W+ +G E+   +        
Sbjct: 2121 LVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGD-------- 2172

Query: 667  ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD-----SAALTIQESPVHILSPQ 721
              +YR+      H L +  +   D+     +SC  V+D     +A L ++ + V  +   
Sbjct: 2173 --KYRMHSDRKVHFLSILTIDTSDAE---DYSCVLVEDENVKTTAKLIVEGAVVEFVKEL 2227

Query: 722  DRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ 781
              + +  + S    L C +S  +    WY +  +++ +    +     +  L + +   +
Sbjct: 2228 QDIEVPESYSGE--LECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKE 2285

Query: 782  DSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
            D GE+    +G      + ++  P+ I+       V     + V L  +V  E     W 
Sbjct: 2286 DQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKV--CEGDIVQLEVKVSLESVEGVWM 2343

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            KDGQEV+ SD V +  +     L++      D G +          FT+    +S+    
Sbjct: 2344 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYS---------FTIPALGLST---- 2390

Query: 902  PSGKVYVAAVRL------------ERVVLTCELCRP-WAEVRWTKDGEEVVESPALLLQK 948
             SG+V V +V +             + VL C++  P    V+W  + E++     +    
Sbjct: 2391 -SGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV 2449

Query: 949  EDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV 1008
            + T +RLV+      D G Y   +     +  ++V +  ++II    ++T      + VV
Sbjct: 2450 KGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK--IKIIRGLRDLT--CTETQNVV 2505

Query: 1009 LMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA 1068
               ELS     V W     E++ S    +E  G   +L +     +D G++   AG++  
Sbjct: 2506 FEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMT 2565

Query: 1069 FFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQ 1128
               +TV      I  P     D            CEVA   S+  W +DG  +  ++ ++
Sbjct: 2566 SGKLTVAGGA--ISKPLT---DQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIR 2620

Query: 1129 LGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPG 1188
              ++G  R L +   + +D GEY  +     +  +   A+  V+ + ++ T   L V   
Sbjct: 2621 SESDGHKRRLIIAATKLDDIGEYTYK-----VATSKTSAKLKVEAVKIKKTLKNLTVTET 2675

Query: 1189 EPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
            +  V + EL+      V W  NG  ++  E   +  +G    L I+        +Y  + 
Sbjct: 2676 QDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRL 2735

Query: 1248 GAAPGAPSLSF-TVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
            G    +  L   TV++ + P  V A E A               V +S    PV+W+   
Sbjct: 2736 GRLGASARLHVETVKIIKKPKDVTALENATVAFE----------VSVSHDTVPVKWFHKS 2785

Query: 1307 ERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSEL 1366
              +    + +L        L +Q     DAGEY     Q      + VE   + K +  +
Sbjct: 2786 VEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNI 2845

Query: 1367 TPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDA 1426
                V E   A+F CEVS  +    WL+NG  +    + ++   G    L +      D+
Sbjct: 2846 E---VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDS 2902

Query: 1427 GTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRG 1486
               T   G+   SA L V  T ++    L+D+ AEE   +  EV     G +   +W++ 
Sbjct: 2903 AEYTFVCGNDQVSATLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGIS--YKWLKN 2958

Query: 1487 GQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPL 1546
            G  +    +  M      H L I  V   D   Y   +    + A L V  R +   + +
Sbjct: 2959 GVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHI 3018

Query: 1547 EDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADS 1606
            +D+ + E   A F+ E+S+  +T +W +   +L    +  I  + + HRL++    ++D+
Sbjct: 3019 KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3078

Query: 1607 GCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGN 1666
            G  +  A      A+L V    V I     +++V E   A  E E+++   D  W KDG 
Sbjct: 3079 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3138

Query: 1667 ALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
             +    + R + +  RR+  + +     SDAG Y+   G  R+             VL E
Sbjct: 3139 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQE 3198

Query: 1725 LRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
            L+ V+ + G  A F   +S   +    W    + L  G + +   +G+++ L+L E   E
Sbjct: 3199 LQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3258

Query: 1784 DAG----EVRFQAGPAQSLALLEVEALPL-----QMCRHPPREKTVLV------GRRAVL 1828
            DA     E +   G A + A L VE   +     +M  +PP   T L       G+ A  
Sbjct: 3259 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318

Query: 1829 EVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQ 1884
            +  VS +   V W  +  ++ P   + M     T+ L I +  PED+GTY   A    GQ
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3378

Query: 1885 DSTHTRLLVE 1894
             S+   L +E
Sbjct: 3379 VSSTANLSLE 3388



 Score =  254 bits (649), Expect = 6e-67
 Identities = 394/1834 (21%), Positives = 682/1834 (37%), Gaps = 213/1834 (11%)

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
            AP      +SQ V +G++     R  G P+P   W K+G+ ++       +   P   ED
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER--SDRIYWYWP---ED 2085

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
                 L +R + A   DS   +  A N  G   + A L V                 ++ 
Sbjct: 2086 NV-CELVIRDVTAE--DSASIMVKAINIAGETSSHAFLLVQAKQ-------------LIT 2129

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
              +         +   A F C    +P  +++W+ +G  +    +  M+ DR   F L +
Sbjct: 2130 FTQELQDVVAKEKDTMATFECET-SEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHF-LSI 2187

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            L     D   Y C          +A +L V+   + F + LQD+E  E     LEC V  
Sbjct: 2188 LTIDTSDAEDYSCVLVEDENVKTTA-KLIVEGAVVEFVKELQDIEVPESYSGELECIVSP 2246

Query: 367  SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
              I   W+  D  L    KY        + L +  +  +D G Y   + G+  T      
Sbjct: 2247 ENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCK---- 2302

Query: 427  KGPILKRLPRKLDVL---------EGENAVLLVETLEAGVEGRWSRDGEELP------VI 471
                LK  PR + +L         EG+   L V+     VEG W +DG+E+       ++
Sbjct: 2303 ----LKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIV 2358

Query: 472  CQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHK 531
                S   H L++  +T+EDAG  +F++     +T  RV         P     + +G K
Sbjct: 2359 IDKQS---HMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTK 2415

Query: 532  NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
              +      P+    T   + L  +++  +D +Q         + +       EG Y+  
Sbjct: 2416 AVLECKVSVPDV---TSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLI 2472

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
            +  V  +              V   +++ GL D+   + ++ VF ++LS         +G
Sbjct: 2473 VGRVETNCNLS----------VEKIKIIRGLRDLTCTETQNVVFEVELSH--------SG 2514

Query: 652  EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
             ++  N  + +++P + +Y+IE  G  ++L +  +   D G    ++   +  S  LT+ 
Sbjct: 2515 IDVLWNFKDKEIKPSS-KYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMT-SGKLTVA 2572

Query: 712  ESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKH 771
               +     +     T   S+  V  CE++  D    W +DG+ +  +  +  + DG K 
Sbjct: 2573 GGAIS----KPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKR 2628

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVH-------IVDPREHVFVHAITSEC 824
            RLI+   K+ D GE+  +         + V+   +        + + ++ VF   +T   
Sbjct: 2629 RLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPN 2688

Query: 825  VMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDE 884
            V            V+W K+G  +E ++   +  +G    L +            C   DE
Sbjct: 2689 VK----------GVQWIKNGVVLESNEKYAISVKGTIYSLRIK----------NCAIVDE 2728

Query: 885  CAY-FTVTITDVSSWIVYPSGKVY-----VAAVRLERVVLTCELCRPWAEVRWTKDGEEV 938
              Y F +     S+ +   + K+      V A+    V     +      V+W     E+
Sbjct: 2729 SVYGFRLGRLGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEI 2788

Query: 939  VESPALLLQKEDTVRRLVLPAVQLEDSGEYLC---EIDDESASF--TVTVTEPPVRIIYP 993
              S    L  E  V +L+L  +   D+GEY     +++ ++  F  T+ +T+    I  P
Sbjct: 2789 KPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVP 2848

Query: 994  RDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQP 1053
              +              CE+S  + P  W K+G+E+E SE   +   G   +L++     
Sbjct: 2849 ETKTASFE---------CEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTST 2899

Query: 1054 EDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVR 1113
            ED  E+    G+D    T+TVT      +   +   D++      +     V   G   +
Sbjct: 2900 EDSAEYTFVCGNDQVSATLTVTP-----IMITSMLKDINAEEKDTITFEVTVNYEGISYK 2954

Query: 1114 WYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQF 1173
            W K+G+E++++D  Q+  +  T +L + +    DA +Y         T  + +    ++F
Sbjct: 2955 WLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEF 3014

Query: 1174 LALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQ 1233
                     + V   +  +  CE+S     V W  + + +Q  + +++  E     L I 
Sbjct: 3015 ---RKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIP 3071

Query: 1234 AAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
            +   + AG YT  +G       L   V+  +  +R +  E    +V       +E  V+ 
Sbjct: 3072 STRMSDAGKYTVVAGGNVSTAKLF--VEGRDVRIRSIKKEV---QVIEKQRAVVEFEVNE 3126

Query: 1294 SGPGGPVRWYKDGERLASQGRVQLEQAGARQVLR--VQGARSGDAGEYLCDAPQDSRIFL 1351
                    WYKDG  +  Q + + +    R++ R  +   R  DAGEY   A ++     
Sbjct: 3127 DDVDA--HWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVT 3184

Query: 1352 VSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPGPQVEMAQN 1410
            + V  P   +++ EL P+TV  G  A F   +S  P   ++W +   +++ G + +   +
Sbjct: 3185 LYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHD 3244

Query: 1411 GSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELL------------FLRR 1454
            G    L L      DA   T  A    G   TSA L V   E++             +  
Sbjct: 3245 GQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITP 3304

Query: 1455 LQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVIL 1514
            LQD    EGQ    +      G    V W    + +       M Q    ++L I     
Sbjct: 3305 LQDTVTSEGQPARFQCRVS--GTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYP 3362

Query: 1515 ADQGTYGCESHHD----RTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQE---- 1566
             D+GTY   + +      + A LS+  + L      +DV  S    A      ++E    
Sbjct: 3363 EDEGTYTFVASNAVGQVSSTANLSLEVQALDRQSSGKDVRESAKSQAVADSSFTKEESKI 3422

Query: 1567 ------GVTGEWARGGVQLYPG-PKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
                     G      VQ++    +  IH+        +    L  +  +S  A+S   +
Sbjct: 3423 SQKEIKSFQGSSYEYEVQVFESVSQSSIHTAAS-----VQDTQLCHTASLSQIAESTELS 3477

Query: 1620 ---ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLR 1675
               A+    E P   +    D+ V  GDTA F C L   +  DVTW  +G  +  S RL+
Sbjct: 3478 KECAKESTGEAPKIFLH-LQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESERLK 3536

Query: 1676 LQALGTRRLLQLRRCGPSDAGTYSCAVGT---ARAGPVRLTVRERTVAVLSELRSVSARE 1732
                G  + L +      D G YSC V      R     L+V     ++L E R     E
Sbjct: 3537 QSQNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGAPESILHE-RIEQEIE 3595

Query: 1733 GDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA 1792
             +   F  +    E  G      +  +    + +  E   +    ++  +E  G      
Sbjct: 3596 MEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYP---TKFDSEKEG-----T 3647

Query: 1793 GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPG 1851
            GP   + + EV    + M            G  A L VTV       + W   G  L P 
Sbjct: 3648 GP---IFIKEVSNADISM------------GDVATLSVTVIGIPKPKIQWFFNGVLLTPS 3692

Query: 1852 DKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQD 1885
              Y+    G  HSL+I   + ED+G Y C A  D
Sbjct: 3693 ADYKFVFDGDDHSLIILFTKLEDEGEYTCMASND 3726



 Score =  223 bits (568), Expect = 1e-57
 Identities = 293/1337 (21%), Positives = 521/1337 (38%), Gaps = 127/1337 (9%)

Query: 618  LVAGLEDVQVYDGEDAVFSLDLST-IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKG 676
            ++ GL D +V +G+     + +S   ++G W  +G+E++ ++          R  I    
Sbjct: 2312 ILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSD----------RVHIVIDK 2361

Query: 677  LQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVL 736
              H L++  +  +D+G    F+ P +  S +  +    V +++P   V++   T  + VL
Sbjct: 2362 QSHMLLIEDMTKEDAGNY-SFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGT--KAVL 2418

Query: 737  TCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA 795
             C++S  D  +  WY + ++++  + +   + G K RL++      D G ++     V  
Sbjct: 2419 ECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVET 2478

Query: 796  FFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVL 855
               ++V+   + I   R+   +    ++ V+   E+      V W    +E++ S    +
Sbjct: 2479 NCNLSVEKIKI-IRGLRD---LTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKI 2534

Query: 856  ENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLER 915
            E  G   +L +      D G++   AG+      +T+   +  I  P     VA    + 
Sbjct: 2535 EAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGA--ISKPLTDQTVA--ESQE 2590

Query: 916  VVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE 975
             V  CE+  P ++  W +DG+ +  +  +  + +   RRL++ A +L+D GEY  ++   
Sbjct: 2591 AVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATS 2650

Query: 976  SASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEA 1034
              S  + V    ++    +    L     +  V   EL+  +   V+W K+G+ +E +E 
Sbjct: 2651 KTSAKLKVEAVKIK----KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEK 2706

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFG 1094
              +   G    L +      D   +    G   A   + V       V    +  D+   
Sbjct: 2707 YAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET-----VKIIKKPKDVTAL 2761

Query: 1095 APGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
                V     V+     V+W+   +E++ SD  +L +E     L L +  P DAGEY   
Sbjct: 2762 ENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAV 2821

Query: 1155 TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQ 1214
                     +      V+ L +  T   + V   +     CE+S    P +W  NG  ++
Sbjct: 2822 VGQLECKAKLF-----VETLHITKTMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIE 2876

Query: 1215 EGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEA 1274
              E  ++  +G    L I       +  YT   G    + +L+ T  +    ++ +  E 
Sbjct: 2877 MSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAEE 2936

Query: 1275 AQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
              T         +   V ++  G   +W K+G  + S  + Q+        L ++    G
Sbjct: 2937 KDT---------ITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFG 2987

Query: 1335 DAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLR 1394
            DA +Y   A + +    + VE    ++    +  + V E   A F CEVS PD  V W++
Sbjct: 2988 DAADYTFVAGKATSTATLYVEARH-IEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMK 3046

Query: 1395 NGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRR 1454
            +   +    ++++ +      L +   ++ DAG  T+ AG   ++A+L V   ++     
Sbjct: 3047 DDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSI 3106

Query: 1455 LQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHD--SRLSMAQDGHIHRLFIHGV 1512
             ++V+  E Q   +E E           W + G  +      R     +  IHR+FI   
Sbjct: 3107 KKEVQVIEKQRAVVEFEVNEDDVDA--HWYKDGIEINFQVQERHKYVVERRIHRMFISET 3164

Query: 1513 ILADQGTYGCESHHDRTLARLSVR-PRQLRVLRPLEDVTISEGGSATFQLELSQEGVTG- 1570
              +D G Y   +  +R+   L V  P   +VL+ L+ VT+  G  A F   +S       
Sbjct: 3165 RQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKI 3224

Query: 1571 EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC----------VSFTADSLRCAA 1620
             W +    L  G KC    DG  + L+L      D+            V+ T+ SL    
Sbjct: 3225 SWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 3284

Query: 1621 RLIV---REVPV---TIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRL 1674
              +V   +E+PV    I+    D   +EG  A F+C +S     V+W      + PS   
Sbjct: 3285 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 3344

Query: 1675 RLQALGTRRLLQLRRCGPSDAGTY----SCAVGTARAGP-----------------VRLT 1713
            R+        L++    P D GTY    S AVG   +                   VR +
Sbjct: 3345 RMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEVQALDRQSSGKDVRES 3404

Query: 1714 VRERTVAVLS---ELRSVSARE---GDGATFECTVSEVETTGRWELGGRPLRPGARVRIR 1767
             + + VA  S   E   +S +E     G+++E  V   E+  +       +   A V+  
Sbjct: 3405 AKSQAVADSSFTKEESKISQKEIKSFQGSSYEYEVQVFESVSQ-----SSIHTAASVQDT 3459

Query: 1768 Q----EGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVG 1823
            Q         I   +EL  E A E   +A P   L L +V               TV  G
Sbjct: 3460 QLCHTASLSQIAESTELSKECAKESTGEA-PKIFLHLQDV---------------TVKCG 3503

Query: 1824 RRA-VLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC-- 1880
              A  L V    S   V W  EGA++   ++ +   +G    L I +V+  DQG Y C  
Sbjct: 3504 DTAQFLCVLKDDSFIDVTWTHEGAKIEESERLKQSQNGNIQFLTICNVQLVDQGLYSCIV 3563

Query: 1881 --QAGQDSTHTRLLVEG 1895
                G+ +T   L VEG
Sbjct: 3564 HNDCGERTTSAVLSVEG 3580



 Score =  212 bits (540), Expect = 2e-54
 Identities = 423/1972 (21%), Positives = 721/1972 (36%), Gaps = 258/1972 (13%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF--PADGAEHGLLLTAALPTDAG 80
            V  G++A  +  V+G+P P   W K G ++  S+R+ +  P D     L++      D+ 
Sbjct: 2043 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCE-LVIRDVTAEDSA 2101

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
              + +A N AGE  + A + V                           +  T      V 
Sbjct: 2102 SIMVKAINIAGETSSHAFLLVQAKQL----------------------ITFTQELQDVVA 2139

Query: 141  RGAEVVLT--CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            +  + + T  C     P   + W KDGM   EV +   + +   R          L IL 
Sbjct: 2140 KEKDTMATFECETSE-PFVKVKWYKDGM---EVHEGDKYRMHSDRKVH------FLSILT 2189

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN 258
                D+  Y C             L++      +     + A    V+ L+       V 
Sbjct: 2190 IDTSDAEDYSC------------VLVEDENVKTTAKLIVEGAVVEFVKELQ----DIEVP 2233

Query: 259  EGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
            E    +  C V   PE  IE  W    + L    +     R G   L V     +D+G Y
Sbjct: 2234 ESYSGELECIV--SPE-NIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEY 2290

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
                        +  +L +K   +   + L D +  E  I  LE KV    +   W ++ 
Sbjct: 2291 SFVIDGKK----TTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDG 2346

Query: 378  QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM-------RGRVRTVANVTVKGPI 430
            Q + P  +   + +     L+I  +  +D G Y   +        GRV +V +V V  P+
Sbjct: 2347 QEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRV-SVYSVDVITPL 2405

Query: 431  LKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPV---ICQSSSGHMHALVLPG 486
                 + ++V+EG  AVL  +     V   +W  + E++     +     G    LV+  
Sbjct: 2406 -----KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 2460

Query: 487  VTREDAGEVTFSLGNSRTTTLLRVKCVK--------HSPPGPPILAEMFKGHKNT-VLLT 537
                D G     +G   T   L V+ +K               ++ E+   H    VL  
Sbjct: 2461 THASDEGPYKLIVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520

Query: 538  WKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
            +K  E  P +   Y++E              I K   + +  D    EG Y F       
Sbjct: 2521 FKDKEIKPSSK--YKIEAHG----------KIYKLTVLNMMKD---DEGKYTFYAGENMT 2565

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKS 656
             G+   +   G A   P       L D  V + ++AVF  +++    +G W  +G+ L  
Sbjct: 2566 SGK---LTVAGGAISKP-------LTDQTVAESQEAVFECEVANPDSKGEWLRDGKHL-- 2613

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVH 716
                    P     R E  G + RLI+ A K  D G    +     + SA L ++   + 
Sbjct: 2614 --------PLTNNIRSESDGHKRRLIIAATKLDDIGEYT-YKVATSKTSAKLKVEAVKIK 2664

Query: 717  ILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLIL 775
                +   +LT T ++  V T EL+  +     W K+G  +E +E   + + G  + L +
Sbjct: 2665 ----KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI 2720

Query: 776  PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
                + D   +  R   + A   + V+   + I  P++   V A+ +  V     V  + 
Sbjct: 2721 KNCAIVDESVYGFRLGRLGASARLHVETVKI-IKKPKD---VTALENATVAFEVSVSHDT 2776

Query: 836  APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-ECA----YFTV 890
             PV+W+    E++ SD   L +E    +L+L    PSD GE+  V G  EC       T+
Sbjct: 2777 VPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL 2836

Query: 891  TITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKED 950
             IT     I  P  K              CE+        W K+G E+  S    +  + 
Sbjct: 2837 HITKTMKNIEVPETKT---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQG 2887

Query: 951  TVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM 1010
             + +L++     EDS EY     ++  S T+TVT  P+ I     ++   A   + +   
Sbjct: 2888 KLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVT--PIMITSMLKDIN--AEEKDTITFE 2943

Query: 1011 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 1070
              ++ E    +W K+G+E++ ++   +        L +      D  ++   AG  ++  
Sbjct: 2944 VTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTA 3003

Query: 1071 TVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
            T+ V A   R +       D+      R    CEV+     V+W KD  E++ +D +++ 
Sbjct: 3004 TLYVEA---RHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQ 3060

Query: 1131 AEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEP 1190
             E     L +P  +  DAG+Y         T  + +    V+  +++     + V   + 
Sbjct: 3061 KEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIK---KEVQVIEKQR 3117

Query: 1191 VVLSCELSRAGAPVVWSHNGRPV--QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
             V+  E++       W  +G  +  Q  E  +   E     + I     + AG YT  +G
Sbjct: 3118 AVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAG 3177

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGE 1307
                  S++  V   EPP   V  E     V+S  G        +SG P   + WYK+ +
Sbjct: 3178 R--NRSSVTLYVNAPEPPQ--VLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKEEQ 3231

Query: 1308 RLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL----VSVEEPLLVKLV 1363
             L++  + +    G    L +  A   DA  Y C+A  D  +      +SVE P +V   
Sbjct: 3232 LLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPD 3291

Query: 1364 SEL--------TPL---TVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGS 1412
             E+        TPL      EG  A F+C VS  D  V+W      + P     M Q   
Sbjct: 3292 QEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFED 3351

Query: 1413 SRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLFLRRLQDVRAEEGQDVCL 1468
            +  L +      D GT T  A    G  +++A L +    L      +DVR         
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEVQALDRQSSGKDVRESAKSQAVA 3411

Query: 1469 EVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDR 1528
            +    +  +  + + ++  Q   ++  + + +   + +  IH    + Q T  C +    
Sbjct: 3412 DSSFTKEESKISQKEIKSFQGSSYEYEVQVFES--VSQSSIH-TAASVQDTQLCHTASLS 3468

Query: 1529 TLARLSVRPRQL---------RVLRPLEDVTISEGGSATFQLELSQEG-VTGEWARGGVQ 1578
             +A  +   ++          ++   L+DVT+  G +A F   L  +  +   W   G +
Sbjct: 3469 QIAESTELSKECAKESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAK 3528

Query: 1579 LYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDL 1638
            +    +     +G+   L +  + L D G  S    +  C  R       V  V G  + 
Sbjct: 3529 IEESERLKQSQNGNIQFLTICNVQLVDQGLYSCIVHN-DCGERTTSA---VLSVEGAPES 3584

Query: 1639 EVTEGDTATFECELSQALAD-VTWEKDGNALTPSPRLRLQALG-TRRLLQLRRCGPSDAG 1696
             + E      E E+ +  +  ++ E++G     S  L+L  +  T  LL       S++ 
Sbjct: 3585 ILHERIEQEIEMEMKEFSSSFLSAEEEG---LHSAELQLSKINETLELL-------SESP 3634

Query: 1697 TYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGG 1755
             Y     + + G   + ++E + A +S         GD AT   TV  +     +W   G
Sbjct: 3635 VYPTKFDSEKEGTGPIFIKEVSNADISM--------GDVATLSVTVIGIPKPKIQWFFNG 3686

Query: 1756 RPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAG---------------------- 1793
              L P A  +   +G  H L++   + ED GE    A                       
Sbjct: 3687 VLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHK 3746

Query: 1794 --PAQSLALLEVEALPLQMCRHPPREKTVL---VGRRAVLEVTV-SRSGGHVCWLREGAE 1847
                +S     +E L      H  +E   +    G  A+ E TV       V W +E  +
Sbjct: 3747 DTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQ 3806

Query: 1848 LCPGDKYEMRSHGPTHS--LVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
            LC    Y +  H P  S   +++D + ED G Y C+A    G+ +    LLV
Sbjct: 3807 LCTSVYYTI-IHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3857



 Score =  212 bits (539), Expect = 3e-54
 Identities = 217/957 (22%), Positives = 410/957 (42%), Gaps = 63/957 (6%)

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
            K   V  G+ A F C +  +  P +EW+ +G+ L P  + ++ R       L +   + +
Sbjct: 5898 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDK-VVPRSEGKVHTLTLRDVKLE 5955

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
            D G     A++      +   L VKEP + FT+PL+D    E   AVLEC+V        
Sbjct: 5956 DAGEVQLTAKDFK----THANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 6011

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            WF+    +L  +KYE + +G VR+L+IH    +D   Y C+ +   +T  N+ V  P ++
Sbjct: 6012 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD-FKTSCNLNVVPPHVE 6070

Query: 433  --RLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGV 487
              R    L V E E A    E      + +W +DG E+    +    S G +  LV+   
Sbjct: 6071 FLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKC 6130

Query: 488  TREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPET 547
              +D  E +  +  +RT+ +L V  ++        LA +     +T+ L  +  +P  E 
Sbjct: 6131 LLDDEAEYSCEVRTARTSGMLTV--LEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEV 6188

Query: 548  PFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFH 607
              I+    +E+      +  +  +   + +    +   G+Y  R+ +    G+   V  H
Sbjct: 6189 --IWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK---VKVH 6243

Query: 608  GSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPG 666
              A     A  ++  +++++ +GE A F   +S       W  + + L+S +        
Sbjct: 6244 ELA-----AEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGD-------- 6290

Query: 667  ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSL 726
              +Y +   G +  L++     QD G  V       + +A LT+ E    ++  +D    
Sbjct: 6291 --KYDVIADGKKRVLVVKDATLQDMGTYV-VMVGAARAAAHLTVIEKLRIVVPLKD---T 6344

Query: 727  TFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF 786
                 + VV  CE++     A W+++ + + +S   ++      + L + +A + D   +
Sbjct: 6345 RVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANY 6404

Query: 787  EC-----RTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
                   R E V +   + V++  + IV+P +   +  +  + V   C+V+R +  ++W 
Sbjct: 6405 NVSLTNHRGENVKSAANLIVEEEDLRIVEPLKD--IETMEKKSVTFWCKVNRLNVTLKWT 6462

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            K+G+EV   + V    +     L +      D GE+   AG + +   + I +  +  V 
Sbjct: 6463 KNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVE 6522

Query: 902  PSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQ 961
                  V     +  V +C+L R  A V+W ++G E+ E      +K+ ++ RL++   +
Sbjct: 6523 HLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCR 6580

Query: 962  LEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVR 1021
            L+D  EY C ++D  +   + V E PV II P  ++  +      VV + EL+++   V+
Sbjct: 6581 LDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDI--LEAPGADVVFLAELNKDKVEVQ 6638

Query: 1022 WYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERI 1081
            W ++ + V + +   +  +G   RL +   +P D GE+   A D  A   + + A P+  
Sbjct: 6639 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELAAAPK-- 6696

Query: 1082 VHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLP 1141
            +  A + L +  G P  + +  +  P  ++  W+K   E E      +       +  + 
Sbjct: 6697 IKTADQDLVVDVGKPLTMVVPYDAYPK-AEAEWFK---ENEPLSTKTIDTTAEQTSFRIL 6752

Query: 1142 HAQPEDAGEY--VCETRHEA----ITFNVILAEPPVQFLAL-ETTPSPLCVAPGEPV 1191
             A+  D G Y  V + +H      I   VI    PV+ L + ET    + +A  EP+
Sbjct: 6753 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPL 6809



 Score =  202 bits (514), Expect = 3e-51
 Identities = 155/558 (27%), Positives = 257/558 (46%), Gaps = 27/558 (4%)

Query: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNG 1411
            S+E P   K+   +   TV +G DA FR  V   PD +  W +NG  +    ++      
Sbjct: 2028 SMEAP---KIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPE 2084

Query: 1412 SSRI-LTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELL-FLRRLQDVRAEEGQD 1465
             +   L +R     D+ ++ ++A    G T++ A L V+  +L+ F + LQDV A+E   
Sbjct: 2085 DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDT 2144

Query: 1466 VC-LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC-- 1522
            +   E ET        V+W + G  +    +  M  D  +H L I  +  +D   Y C  
Sbjct: 2145 MATFECETSEPFVK--VKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVL 2202

Query: 1523 -ESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
             E  + +T A+L V    +  ++ L+D+ + E  S   +  +S E + G+W    V+L  
Sbjct: 2203 VEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKS 2262

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
              K  I S   R  L +  +   D G  SF  D  +   +L ++  P+ I++G  D +V 
Sbjct: 2263 NGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVC 2322

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC- 1700
            EGD    E ++S    +  W KDG  + PS R+ +       +L +      DAG YS  
Sbjct: 2323 EGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFT 2382

Query: 1701 --AVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRP 1757
              A+G + +G V +     +V V++ L+ V+  EG  A  EC VS  + T  +W L    
Sbjct: 2383 IPALGLSTSGRVSV----YSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQ 2438

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            ++P  RV+   +G K  LV++   A D G  +   G  ++   L VE + +       R+
Sbjct: 2439 IKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIKI---IRGLRD 2495

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
             T    +  V EV +S SG  V W  +  E+ P  KY++ +HG  + L + ++  +D+G 
Sbjct: 2496 LTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGK 2555

Query: 1878 YCCQAGQDSTHTRLLVEG 1895
            Y   AG++ T  +L V G
Sbjct: 2556 YTFYAGENMTSGKLTVAG 2573



 Score =  189 bits (480), Expect = 2e-47
 Identities = 271/1226 (22%), Positives = 469/1226 (38%), Gaps = 182/1226 (14%)

Query: 15   LRFPRPVRVVSGAEAE--LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
            L+F  P++ V+  E E  +  V L      V W K  Q+L  +  +S   +G  H +   
Sbjct: 5624 LKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFK 5683

Query: 73   AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                 D       A   + EA     +TVLE                      G P F  
Sbjct: 5684 DLSIDDTSQIRVEAMGMSSEA----KLTVLE----------------------GDPYFTG 5717

Query: 133  GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
              +    +   EV+L C       P + W KDG    E+  S +  ++     DG    L
Sbjct: 5718 KLQDYTGVEKDEVILQCEISKADAP-VKWFKDGK---EIKPSKNAVIKA----DGKKRML 5769

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             L+   A   D G Y C                      S   D ++    +V PL    
Sbjct: 5770 ILK--KALKSDIGQYTCDCGT---------------DKTSGKLDIEDREIKLVRPLHSVE 5812

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
                V E + A+F   +    E +I  +W+ +               G  +L+   C+ K
Sbjct: 5813 ----VMETETARFETEIS---EDDIHANWKLK---------------GEALLQTPDCEIK 5850

Query: 313  DRG------LYVCAARNSAG------QTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVL 360
            + G      L+ C    + G         S+  L VK   +   RPL+DV       A  
Sbjct: 5851 EEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATF 5910

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420
            +C++    IP  W+ + ++L P  K     EG V  L +  +K +D G      +   +T
Sbjct: 5911 DCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD-FKT 5969

Query: 421  VANVTVKGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SS 475
             AN+ VK P ++      D  V EG  AVL  E      + +W ++G E+    +    +
Sbjct: 5970 HANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVA 6029

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
             G +  LV+   T ED    T    + +T+  L V      PP    L  +         
Sbjct: 6030 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV-----VPPHVEFLRPLTD------- 6077

Query: 536  LTWKPPEPAPETPFIYRLERQEVGSEDWIQC-----FSIEKAGAVE--VPGDC-VPSEGD 587
            L  +  E A     + R   +    +D  +      + I   GAV   V   C +  E +
Sbjct: 6078 LQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAE 6137

Query: 588  YRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGT 646
            Y   + T    G            L   A     L +++V + +      ++S    +  
Sbjct: 6138 YSCEVRTARTSGM--------LTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVI 6189

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSC--PGVQD 704
            W+   EE+        +E G  RY I  +G +  L++     +D+G    ++C  P  + 
Sbjct: 6190 WYKGDEEI--------IETG--RYEILTEGRKRILVIQNAHLEDAG---NYNCRLPSSRT 6236

Query: 705  SAALTIQESPVHILS-PQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLV 763
               + + E     +S PQ   +L     E+    C +S+  FP  W +D + +E  +   
Sbjct: 6237 DGKVKVHELAAEFISKPQ---NLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGDKYD 6293

Query: 764  VKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSE 823
            V  DG+K  L++ +A +QD G +        A   +TV +  + IV P +   V     +
Sbjct: 6294 VIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK--EQQ 6350

Query: 824  CVMLACEVDREDAPVRWYKDGQEV-EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882
             V+  CEV+ E A  +W+++ + + + S +++L+ +  +   +  A              
Sbjct: 6351 EVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHL------------ 6398

Query: 883  DECAYFTVTITDVSSWIVYPSGKVYV--------------AAVRLERVVLTCELCRPWAE 928
            D+ A + V++T+     V  +  + V                +  + V   C++ R    
Sbjct: 6399 DDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVT 6458

Query: 929  VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPV 988
            ++WTK+GEEV     +  + +     L +      D GEY+     + +   + + E P 
Sbjct: 6459 LKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPT 6518

Query: 989  RIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVL 1048
              +   ++ T+     +  V  C+LSRE A V+WY++G E++E +    E+DG   RL++
Sbjct: 6519 EFVEHLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLII 6576

Query: 1049 PAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR-VELRCEVAP 1107
               + +D  E+ C   D  +   + V   P  I+ P    L+    APG  V    E+  
Sbjct: 6577 KDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILE----APGADVVFLAELNK 6632

Query: 1108 AGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILA 1167
               +V+W ++ + V   D  Q+ +EG    L +   +P D GEY    + +     + LA
Sbjct: 6633 DKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELA 6692

Query: 1168 EPPVQFLALETTPSPLCVAPGEPVVL 1193
              P     ++T    L V  G+P+ +
Sbjct: 6693 AAP----KIKTADQDLVVDVGKPLTM 6714



 Score =  116 bits (290), Expect = 2e-25
 Identities = 219/1074 (20%), Positives = 389/1074 (36%), Gaps = 173/1074 (16%)

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+ DGQ++  + +  VV++ +G    +++PAT PSD GE+  VA +     ++++     
Sbjct: 1444 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPAT-PSDSGEWTVVAQNRAGRSSISVILTVE 1502

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             + +    ++V  ++   +    E  R   +VR T +    +    + L+  D +     
Sbjct: 1503 AVEHQVKPMFVEKLKNVNIK---EGSRLEMKVRATGNPNPDI----VWLKNSDIIVPHKY 1555

Query: 958  PAVQLEDS-GEYLCEID----DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
            P +++E + GE   +ID     +SA +T T      R      + T   V +E       
Sbjct: 1556 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGR------DTTRCKVNVEV------ 1603

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCR-LVLPAAQP---------EDGGEFVCD 1062
                        +  E E    L++ R   R + +  P  +P          + G+    
Sbjct: 1604 ------------EFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDK 1651

Query: 1063 AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGL 1119
                  FF   +T+   +   PA      HF         C + P G     V W  DG 
Sbjct: 1652 EKQQKPFFKKKLTSLRLKRFGPA------HF--------ECRLTPIGDPTMVVEWLHDGK 1697

Query: 1120 EVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETT 1179
             +EA++ L++  E    +L    A   D+G   C   ++  T               + T
Sbjct: 1698 PLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGT---------------DHT 1742

Query: 1180 PSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAH 1239
             + L V   + +V   +L            GR     +GL+   E  R          AH
Sbjct: 1743 SATLIVKDEKSLVEESQLP----------EGR-----KGLQRIEELERM---------AH 1778

Query: 1240 AGLYTCQSGAAPGAPSLSFTVQVAEP-PVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGG 1298
             G  T   G             V  P PVRV+  E A+ R R T             P  
Sbjct: 1779 EGALT---GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVT-----------GYPQP 1824

Query: 1299 PVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPL 1358
             V WY +G+ +    R ++   G    L +   +S D GE             V+ E P 
Sbjct: 1825 KVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGE-----------VKVTAENP- 1871

Query: 1359 LVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL 1418
               ++     L + + +D       +P               P P+  + + G  +    
Sbjct: 1872 -EGVIEHKVKLEIQQREDFRSVLRRAP--------------EPRPEFHVHEPGKLQF--- 1913

Query: 1419 RGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAA 1478
                  +   V     +T T   + ++  E +   ++ +   E         E G   A 
Sbjct: 1914 ------EVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 1967

Query: 1479 GAVRWVRGGQPLPHDSRLSMAQDGHIH----RLFIHGVILADQGTYGCESHHDRTLARLS 1534
             AV      +   ++  L   +D  +H            LA++G     +     +  LS
Sbjct: 1968 TAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKI-ELS 2026

Query: 1535 VRPRQLRVLRPLEDVTISEGGSATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIH-SDGH 1592
                  ++   ++  T+ +G  A F++  + +     EW + GV++    + + +  + +
Sbjct: 2027 PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDN 2086

Query: 1593 RHRLVLNGLGLADSG-----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT-A 1646
               LV+  +   DS       ++   ++   A  L+  +  +T  +   D+   E DT A
Sbjct: 2087 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMA 2146

Query: 1647 TFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR 1706
            TFECE S+    V W KDG  +    + R+ +      L +     SDA  YSC +    
Sbjct: 2147 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE 2206

Query: 1707 --AGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARV 1764
                  +L V    V  + EL+ +   E      EC VS     G+W      L+   + 
Sbjct: 2207 NVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKY 2266

Query: 1765 RIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGR 1824
             I     +  L + ++  ED GE  F     ++   L+++  P+ + +    +K V  G 
Sbjct: 2267 TITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQK-VCEGD 2325

Query: 1825 RAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               LEV VS       W+++G E+ P D+  +     +H L+I D+  ED G Y
Sbjct: 2326 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNY 2379



 Score =  100 bits (249), Expect = 1e-20
 Identities = 121/498 (24%), Positives = 198/498 (39%), Gaps = 82/498 (16%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F+  P+ + ++ G +AE  C +  E  PV  W++  + L + ++    ADG +  L++  
Sbjct: 6249 FISKPQNLEILEGEKAEFVCSISKESFPVQ-WKRDDKTLESGDKYDVIADGKKRVLVVKD 6307

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEP-----PASDPELQPAERPLPSPGSGEGAP 128
            A   D G YV       G A AAA +TV+E      P  D  ++  +             
Sbjct: 6308 ATLQDMGTYVV----MVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQ------------- 6350

Query: 129  VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                           EVV  C          ++  +    + ++DSS + +         
Sbjct: 6351 ---------------EVVFNCEVNTEGAKAKWFRNE----EAIFDSSKYIILQ------K 6385

Query: 189  GASLALRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
                 LRI  A L D   Y     N  G + ++ A L V           +E    +VEP
Sbjct: 6386 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIV-----------EEEDLRIVEP 6434

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
            L    K     E K   F C V  +    ++W   G   +P   R+ YR      +L + 
Sbjct: 6435 L----KDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE-VPFDNRVSYRVDKYKHMLTIK 6488

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS 367
             C   D G Y+     +AGQ  S  +L + E    F   L+D    E   AV  C++   
Sbjct: 6489 DCGFPDEGEYIV----TAGQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSRE 6544

Query: 368  RIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK 427
            +    W+R  + +   +KY+  ++G++ RLII   + DD+  Y C +  R ++ A + V+
Sbjct: 6545 KANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDR-KSRARLFVE 6603

Query: 428  GPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQS------SSGHM 479
               ++ +    D+LE  G + V L E  +  VE +W R+     V+ Q       S G +
Sbjct: 6604 EIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNN---MVVVQGDKHQMMSEGKI 6660

Query: 480  HALVLPGVTREDAGEVTF 497
            H L +  +   D GE  F
Sbjct: 6661 HRLQICDIKPRDQGEYRF 6678



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 118/534 (22%), Positives = 204/534 (38%), Gaps = 84/534 (15%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F +  + ++V+    A  +C V  EP   V W K  Q+L  ++R+    +   H LL+ +
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPS 3072

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
               +DAG Y       AG   + A + V                       EG  V +  
Sbjct: 3073 TRMSDAGKYTV----VAGGNVSTAKLFV-----------------------EGRDVRIRS 3105

Query: 134  PRSQ-WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
             + +  V+     V+        +   +W KDG+ ++      H  +   R         
Sbjct: 3106 IKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYVVERRIH------- 3157

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             + I   R  D+G Y   A    G  ++   L V+ P           P  V++ L+  P
Sbjct: 3158 RMFISETRQSDAGEYTFVA----GRNRSSVTLYVNAP----------EPPQVLQELQ--P 3201

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
             T  V  GK A+F   + G+P+P+I W+ E   LL    +  +      + L ++    +
Sbjct: 3202 VT--VQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3258

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRL------------RFTRPLQDVEGREHGIAVL 360
            D  +Y C A+N  G   ++  L V+ P +                PLQD    E   A  
Sbjct: 3259 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY---LCEMRGR 417
            +C+V  + +  +W+ +D+++ P R +   +     +L I     +D+G Y        G+
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3378

Query: 418  VRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSG 477
            V + AN++++   L R     DV E   +  + ++     E + S+  +E+    Q SS 
Sbjct: 3379 VSSTANLSLEVQALDRQSSGKDVRESAKSQAVADSSFTKEESKISQ--KEIKSF-QGSSY 3435

Query: 478  HMHALVLPGVTRED---AGEV-------TFSLGNSRTTTLLRVKCVKHSPPGPP 521
                 V   V++     A  V       T SL     +T L  +C K S    P
Sbjct: 3436 EYEVQVFESVSQSSIHTAASVQDTQLCHTASLSQIAESTELSKECAKESTGEAP 3489



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 98/389 (25%), Positives = 145/389 (37%), Gaps = 67/389 (17%)

Query: 2    KASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFP 61
            K S+G+  +P  FL   + V V  G  A+  CV+  +    V W   G ++  SERL   
Sbjct: 3482 KESTGE--APKIFLHL-QDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESERLKQS 3538

Query: 62   ADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP---------------- 105
             +G    L +      D G+Y C   N  GE   +A ++V   P                
Sbjct: 3539 QNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGAPESILHERIEQEIEMEM 3598

Query: 106  ---------ASDPELQPAERPLP--------------------SPGSGEGAPVFLTGPRS 136
                     A +  L  AE  L                     S   G G P+F+    +
Sbjct: 3599 KEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTG-PIFIKEVSN 3657

Query: 137  QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRI 196
              +  G    L+    G+P+P + W  +G+ L    D            DG   SL   I
Sbjct: 3658 ADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVF-------DGDDHSLI--I 3708

Query: 197  LAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPES-PPADPDEAPAPVVEPL--KCAP- 252
            L  +L D G Y C A N +G     A L+++   E     + + A A  +E L   C P 
Sbjct: 3709 LFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPH 3768

Query: 253  -----KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
                 K     +G  A F   V+G+P P + W  E + L       +  + +G     V 
Sbjct: 3769 FLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVN 3828

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
              Q +D GLY+C A N  G++  A +L V
Sbjct: 3829 DPQREDSGLYICKAENMLGESTCAAELLV 3857



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 116/480 (24%), Positives = 188/480 (39%), Gaps = 54/480 (11%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  L+  +PV V SG  A    V+ G P P + W K  Q L+   +  F  DG E+ LL
Sbjct: 3192 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3251

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            L  A P DA VY C A+N  G A  +A+++V  P    P+ +    P          P  
Sbjct: 3252 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP----------PAI 3301

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +T  +      G      CR  G      ++ KD     ++  S  F +   + ED    
Sbjct: 3302 ITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKD----KKIKPSRFFRMT--QFED---- 3351

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLK- 249
            +  L I  A   D G Y   A NA G   + A L +    E    D   +   V E  K 
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSL----EVQALDRQSSGKDVRESAKS 3407

Query: 250  --CAPKTFWVNEGK--HAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 305
               A  +F   E K    + + +     E E++  +E             +D        
Sbjct: 3408 QAVADSSFTKEESKISQKEIKSFQGSSYEYEVQ-VFESVSQSSIHTAASVQDTQLCHTAS 3466

Query: 306  VLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV- 364
            +    A+   L    A+ S G+    + LH           LQDV  +    A   C + 
Sbjct: 3467 LSQI-AESTELSKECAKESTGEA-PKIFLH-----------LQDVTVKCGDTAQFLCVLK 3513

Query: 365  PNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR---GRVRTV 421
             +S I   W  E  ++    + +Q + G ++ L I  ++  D G+Y C +    G   T 
Sbjct: 3514 DDSFIDVTWTHEGAKIEESERLKQSQNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTS 3573

Query: 422  ANVTVKGP----ILKRLPRKLDVLEGENAVLLVETLEAGV---EGRWSRDGEELPVICQS 474
            A ++V+G     + +R+ +++++   E +   +   E G+   E + S+  E L ++ +S
Sbjct: 3574 AVLSVEGAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSES 3633



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 191/1020 (18%), Positives = 346/1020 (33%), Gaps = 168/1020 (16%)

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVT 891
             A V+WY +G E++ES  +   N      L +      D G ++ V     G+   Y T+ 
Sbjct: 26098 AEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLD 26157

Query: 892   ITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDT 951
             +T    +  Y S +      R     LT      +A   + K  E    S    ++ + T
Sbjct: 26158 VTG-GDYTTYASQRRDEEVPRSVFPELT--RTEAYAVSSFKKTSEMEASSSVREVKSQMT 26214

Query: 952   VRRLVLPAVQLEDSGEYLC------EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLE 1005
               R  L + +   S E          ++++S +  +  T     +  PR   ++     E
Sbjct: 26215 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR---SMTVYEGE 26271

Query: 1006  CVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--- 1061
                  C+   E  P V W + G  +  S    +     +    + + Q  D G +     
Sbjct: 26272 SARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVE 26331

Query: 1062  -DAGDDSAFFTVT----------VTAPPE------RIVHPAA------------------ 1086
                G   A FT+T          VT+PP       R+  P A                  
Sbjct: 26332 NSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAV 26391

Query: 1087  -----------RSLDLHFGAPGRV-------------ELRCEVAPA---GSQVRWYKDGL 1119
                        +   L   AP ++             +L C V  +     +V WYKDG 
Sbjct: 26392 SPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGK 26451

Query: 1120  EVEASDALQL--GAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLAL- 1176
             +++ +   Q    A+G T  L + +    D GEYVCE   E  T    L      F ++ 
Sbjct: 26452 KLKENGHFQFHYSADG-TYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH 26510

Query: 1177  -----------------ETT---------PSPLCVAP-----------GEPVVLSCELSR 1199
                              E+T         P P+   P               V    +  
Sbjct: 26511 EKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKA 26570

Query: 1200  AGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSL 1256
              G P    +W+ +G+ + +G   +L  +     L I     + +GLYTC    + G+ S 
Sbjct: 26571 TGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 26630

Query: 1257  SFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQ 1316
             S  + +           + Q     TP     +   +S         K  E   SQ ++ 
Sbjct: 26631 SCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEA-KSQEKLA 26689

Query: 1317  LEQAGARQVLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGD 1375
             L++  ++ ++  +  +S     E      + ++    S E     ++ +  T ++++EG 
Sbjct: 26690 LKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQ 26749

Query: 1376  DATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGS 1435
                 +  ++    DV W+ NG  +T   +     +GS + LT++     D G +T     
Sbjct: 26750 RLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTC---I 26805

Query: 1436  TATSARLHVRETELLFLRRLQDVRA----------EEGQDVCLEVETGRVGAAGAVRWVR 1485
             + T   +   + +L   + L D  A           EGQ+V    E      +  + W +
Sbjct: 26806 SKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISG-EPSPEIEWFK 26864

Query: 1486  GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDR----TLARLSVRPRQLR 1541
                P+   S +S+++  +++ L I    ++D G Y  ++ + R      A L V P    
Sbjct: 26865 NNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP---L 26921

Query: 1542  VLRPLEDVTISEGGSATFQLELSQEGV--TGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
             V  P  +V +   G  + Q   S + V  +          +        ++     +   
Sbjct: 26922 VEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQ 26981

Query: 1600  GLGLADSGCVSFTADSLRCAARLI-------------VREVPVTIVRGPHDLEVTEGDTA 1646
              +       V  ++ S    + +              +R +P  I   P D+ + EG   
Sbjct: 26982 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 27041

Query: 1647  TFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVG 1703
             T  C  + +   +VTW   G  +    + R     T  L  L +      D G Y+ ++G
Sbjct: 27042 TVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLG 27101



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 113/494 (22%), Positives = 184/494 (37%), Gaps = 82/494 (16%)

Query: 15   LRFPRPVRVVSGAEAELKCVV--LGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
            L+F  P+   +  E E    V  L      VVW K   +L  S  +   ++G  H L + 
Sbjct: 5269 LKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMK 5328

Query: 73   AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                 D    + + +    E  + A + VLE                        P F  
Sbjct: 5329 EVTLDD----ISQIKAQVKELSSTAQLKVLEAD----------------------PYFTV 5362

Query: 133  GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
                +  +   E+ L C      +  + W KDG   +E+  S  ++++        G   
Sbjct: 5363 KLHDKTAVEKDEITLKCEVS--KDVPVKWFKDG---EEIVPSPKYSIK------ADGLRR 5411

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQA---GALLQVHQPPESPPADPDEAPAPVVEPLK 249
             L+I  A L D G YVC        A       L++V            E P   VE   
Sbjct: 5412 ILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKV------------EKPLYGVE--- 5456

Query: 250  CAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL--PDRRRLMYRDRDGGFVLKVL 307
                  +V E  H +     + +P+   +W  +G+PL   PD   +     DG   + +L
Sbjct: 5457 -----VFVGETAHFEIE---LSEPDVHGQWKLKGQPLTASPDCEII----EDGKKHILIL 5504

Query: 308  Y-CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            + CQ    G     A N+     SA  L VKE  L F  PL DV+  E   A  EC+V  
Sbjct: 5505 HNCQLGMTGEVSFQAANAK----SAANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSR 5560

Query: 367  SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
                  W +  Q +    ++E I++GT   ++I     +D+  Y+ E   +  T   + +
Sbjct: 5561 EPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDK-HTSGKLII 5619

Query: 427  KGPILKRLPRKLDVL--EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHA 481
            +G  LK L    DV   E E+AV  VE     +  +W ++ + L     +     G  H+
Sbjct: 5620 EGIRLKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 5679

Query: 482  LVLPGVTREDAGEV 495
            +    ++ +D  ++
Sbjct: 5680 ITFKDLSIDDTSQI 5693



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 63/239 (26%), Positives = 93/239 (38%), Gaps = 32/239 (13%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            +PP  +   + V V+ G    L+C + G P P V W +   Q+ +S             L
Sbjct: 895  TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARL 954

Query: 70   LLTAALPTDAGVYVCRARNAAG-------------EAYAAAAVTVLEPPASDPELQPAER 116
            ++  A   D+G + C A N AG             E +      V E   ++ +     R
Sbjct: 955  MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014

Query: 117  PL---------PSPGSGE-GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGM 166
             +            G GE  AP F+T P  Q ++ G  VV  C+ GG P+P +YW+K G+
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074

Query: 167  ALDEVWD-SSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL 224
             L   +     +  Q G  +        L I      D+G Y    RN HG   A A L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECK--------LVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 92/387 (23%), Positives = 137/387 (35%), Gaps = 78/387 (20%)

Query: 18    PRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPT 77
             PR + V  G  A   C   GEP P V W + GQ L+ S R        +    +++   +
Sbjct: 26262 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQAS 26321

Query: 78    DAGVYVCRARNAAGEAYAAAAVTVL------------------EPPASDPELQPAERPLP 119
             D G Y     N+ G+  A   +T+                   EP    PE   + + + 
Sbjct: 26322 DEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 26381

Query: 120   SPGSG------------------EGAPVFLTGPRSQWVLRGAE---VVLTC--RAGGLPE 156
             SP                     +  PV      +Q++   A      LTC   +  L  
Sbjct: 26382 SPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRA 26441

Query: 157   PTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHG 216
               + W KDG  L E   + HF      + DG   +  L+I      D G YVC      G
Sbjct: 26442 KEVTWYKDGKKLKE---NGHFQFH--YSADG---TYELKINNLTESDQGEYVCEISGEGG 26493

Query: 217   HAQAG------ALLQVHQP--------------PESPPADPDEAPAPVVEPLKCAP---- 252
              ++        A   +H+                ES      E  AP  EP+   P    
Sbjct: 26494 TSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAP--EPISSKPVIVT 26551

Query: 253   --KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
               +   V+    AKF     G+P P   W  +G+ +    +  +  D+ GGF L++    
Sbjct: 26552 GLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDK-GGFFLEIHKTD 26610

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHVK 337
               D GLY C  +NSAG   S+ +L +K
Sbjct: 26611 TSDSGLYTCTVKNSAGSVSSSCKLTIK 26637



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 78/398 (19%)

Query: 22   RVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGLLLTAALPTDA 79
            R++ G      C + G P P + W K G+++   ER  + F  DG    L +   LP D 
Sbjct: 1255 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVLPEDE 1313

Query: 80   GVYVCRARNAAGEAYAAAAVTV-----LEPPASDPELQPAER------------PL---- 118
            G+Y   A N  G A  +  + V     L  P   P L+P  R            P+    
Sbjct: 1314 GIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSP 1373

Query: 119  -----------------PSPG-----SGEG------APVFLTGPRSQWVLRGAEVVLTCR 150
                              SPG     + E        PVF+  P S   L G       +
Sbjct: 1374 ARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLK 1433

Query: 151  AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCH 210
              G P P  +W  DG  +  V D +H  +     EDG   + +L I+ A   DSG +   
Sbjct: 1434 VVGRPMPETFWFHDGQQI--VNDYTHKVV---IKEDG---TQSLIIVPATPSDSGEWTVV 1485

Query: 211  ARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVM 270
            A+N  G +    +L V        A   +     VE L    K   + EG   + +    
Sbjct: 1486 AQNRAGRSSISVILTVE-------AVEHQVKPMFVEKL----KNVNIKEGSRLEMKVRAT 1534

Query: 271  GKPEPEIEWHWEGRPLLPDR-RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTL 329
            G P P+I W      ++P +  ++      G   LK+    ++D   Y   A N AG+  
Sbjct: 1535 GNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDT 1594

Query: 330  SAVQLHVK------EPRLRFTRPLQDVEGREHGIAVLE 361
            +  +++V+      EP  +   P      +E     LE
Sbjct: 1595 TRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELE 1632



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 123/502 (24%), Positives = 190/502 (37%), Gaps = 74/502 (14%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
            G+ A  +C+V      +  W K G  +  S +  F ADG +  L +     +DAG Y C 
Sbjct: 4828 GSSAIFECLV-SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 4886

Query: 86   ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145
             R    E  + A + V E P                          T      V++G  +
Sbjct: 4887 LRLGNKEKTSTAKLVVEELPVR---------------------FVKTLEEEVTVVKGQPL 4925

Query: 146  VLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP-GASLALRILAARLPDS 204
             L+C      E  + W KDG  + E         +PGR   G  G   AL I  A   D+
Sbjct: 4926 YLSCELN--KERDVVWRKDGKIVVE---------KPGRIVPGVIGLMRALTINDADDTDA 4974

Query: 205  GVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAK 264
            G Y     NA+ + +  + ++V +               +V+P+    +   V     A 
Sbjct: 4975 GTYTVTVENAN-NLECSSCVKVVEVIRD----------WLVKPI----RDQHVKPKGTAI 5019

Query: 265  FRCYVMGKPEPEIEWH--WEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
            F C +  K  P I+W   ++  P  P+ +  + RD      LK+     +D   Y   A 
Sbjct: 5020 FACDI-AKDTPNIKWFKGYDEIPAEPNDKTEILRD-GNHLYLKIKNAMPEDIAEY---AV 5074

Query: 323  NSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLP 382
               G+   A +L + E  +   +P++DV   E   A  + ++  + IP  W  + + L P
Sbjct: 5075 EIEGKRYPA-KLTLGEREVELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRP 5133

Query: 383  CRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLE 442
                E   EG  R L +H++K D  G  L +    + T A +TVK   L       DV  
Sbjct: 5134 SPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAI-TTAILTVKEIELDFAVPLKDVTV 5192

Query: 443  GENAVLLVE---TLEAGVEGRWSRDGEELPVICQSS-------SGHMHALVLPGVTREDA 492
             E      E   T EA V   WS+     P I +SS        G  H LV+     +D 
Sbjct: 5193 PERRQARFECVLTREANV--IWSKG----PDIIKSSDKFDIIADGKKHILVINDSQFDDE 5246

Query: 493  GEVTFSLGNSRTTTLLRVKCVK 514
            G  T  +   +T+  L V  ++
Sbjct: 5247 GVYTAEVEGKKTSARLFVTGIR 5268



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 118/552 (21%), Positives = 194/552 (35%), Gaps = 105/552 (19%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGL 69
            P F+  P   ++V G      C V G P P V W+K G  L    R  +S+     E  L
Sbjct: 1036 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1095

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL---------PS 120
            +++     DAG Y    RN  GE   +A+ ++LE    +  ++  +  L           
Sbjct: 1096 VISMTFADDAGEYTIVVRNKHGET--SASASLLEEADYELLMKSQQEMLYQTQVTAFVQE 1153

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
            P  GE AP F+     +   +   ++    A        Y E      D+ +  S F   
Sbjct: 1154 PKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE------DQEFHISSF--- 1204

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240
                E+     +  RI+   L +                    L      E    D  E+
Sbjct: 1205 ----EERLIKEIEYRIIKTTLEE--------------------LLEEDGEEKMAVDISES 1240

Query: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
             A V        K + + EG    F C + G P P+I W+ +G+ +    R  M   +DG
Sbjct: 1241 EA-VESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1299

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK--------------EPRLRFTRP 346
               L++     +D G+Y   A N  G  + + +L+V+              EP  R  R 
Sbjct: 1300 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRI-RS 1358

Query: 347  LQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADD 406
            L         I +   ++  +R+  A      R+ P R+ E+ +E  + RL         
Sbjct: 1359 LSPRSVSRSPIRMSPARMSPARMSPARM-SPARMSPGRRLEETDESQLERLY-------- 1409

Query: 407  DGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGV-EGRWSRDG 465
                                  P+    P     LEG+ A   ++ +   + E  W  DG
Sbjct: 1410 ---------------------KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDG 1448

Query: 466  EEL-----PVICQSSSGHMHALVLPGVTREDAGEVTF----SLGNSRTTTLLRVKCVKHS 516
            +++       +     G    +++P  T  D+GE T       G S  + +L V+ V+H 
Sbjct: 1449 QQIVNDYTHKVVIKEDGTQSLIIVP-ATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQ 1507

Query: 517  PPGPPILAEMFK 528
                P+  E  K
Sbjct: 1508 V--KPMFVEKLK 1517



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 91/395 (23%), Positives = 142/395 (35%), Gaps = 87/395 (22%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA--EHGL 69
            P F+   + V +  G+  E+K    G P P +VW K    +   +      +G   E  L
Sbjct: 1510 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1569

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP-------- 121
             + + +  D+  Y   A N AG       V V E   ++PE    ER L  P        
Sbjct: 1570 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNV-EVEFAEPE---PERKLIIPRGTYRAKE 1625

Query: 122  -GSGEGAPVFLTGPRSQW------------------------VLRGAEVVLTCRAGGLPE 156
              + E  P+ L   + QW                        + R       CR   + +
Sbjct: 1626 IAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGD 1685

Query: 157  PTLY--WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
            PT+   W  DG  L+        A +     +    SL   +  +R  DSG+  C A N 
Sbjct: 1686 PTMVVEWLHDGKPLEA-------ANRLRMINEFGYCSLDYGVAYSR--DSGIITCRATNK 1736

Query: 215  HGHAQAGA---------LLQVHQPPESPPA---------------------DPDEAPAPV 244
            +G     A         L++  Q PE                         D  E   P 
Sbjct: 1737 YGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKP- 1795

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFV 303
               +   P+   V EG+ A+FRC V G P+P++ W+  G+ +   +R R+ Y   DG   
Sbjct: 1796 --DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHY 1850

Query: 304  LKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
            L ++ C++ D G     A N  G     V+L +++
Sbjct: 1851 LDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1885



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 113/549 (20%), Positives = 201/549 (36%), Gaps = 46/549 (8%)

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT---------V 981
             WTKDG+ + +     L ++     L +      DSG Y C + + + S +         +
Sbjct: 26580 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAI 26639

Query: 982   TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
               TE          E+T      +  V+  E+S++       K   E +  E L L+ + 
Sbjct: 26640 KDTEAQKVSTQKTSEIT----PQKKAVVQEEISQKALRSEEIKMS-EAKSQEKLALKEEA 26694

Query: 1042  PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAAR--SLDLHFGAPGRV 1099
              +   VL + + +       +        T T  A  E   H   +  S  +      R+
Sbjct: 26695 SK---VLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 26751

Query: 1100  ELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR-HE 1158
              L+  +A A + V+W  +G+E+  S+  + G  G  +TLT+  A   D G   C ++  E
Sbjct: 26752 VLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKE 26810

Query: 1159  AIT---FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQ 1214
              I    +++ L++      A  + P    +  G+ V+ +CE+S   +P + W  N  P+ 
Sbjct: 26811 GIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS 26870

Query: 1215  EGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS----GAAPGAPSLSFTVQVAEPPVRVV 1270
                 + +        L I+ A  + +G YT ++    G      SL     V EP   VV
Sbjct: 26871 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 26930

Query: 1271  APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQ------GRVQLEQAGARQ 1324
                +  T   S  G      V +S       +       AS         +  +   + Q
Sbjct: 26931 LRTSGDT---SLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQ 26987

Query: 1325  VLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE- 1382
                V+ + S   G   +      +   L +    +  K+ +  + +++ EG   T  C  
Sbjct: 26988 ESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAF 27047

Query: 1383  VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL--RGCQLGDAGTVTL----RAGST 1436
                P  +VTW   G  +    Q       +  + TL     Q  D G  TL      GS 
Sbjct: 27048 TGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSD 27107

Query: 1437  ATSARLHVR 1445
             + +  +H+R
Sbjct: 27108 SATVNIHIR 27116



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 60/208 (28%), Positives = 78/208 (37%), Gaps = 29/208 (13%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASE---RLSFPADGAEHGLLLTAALPTDAGVY 82
             G        +   P P V W K GQ++   +   + +F +D   + L + +    D   Y
Sbjct: 25399 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 25458

Query: 83    VCRARNAAGEAYAAAAVTV-LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLR 141
                ARN  GE    A +TV L PP +D  L+P  + L            L     Q    
Sbjct: 25459 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRL------------LANAECQ---E 25503

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS-LALRILAAR 200
             G  V    R  G+P PTL WEKDG  L         +L P       G    AL I    
Sbjct: 25504 GQSVCFEIRVSGIPPPTLKWEKDGQPL---------SLGPNIEIIHEGLDYYALHIRDTL 25554

Query: 201   LPDSGVYVCHARNAHGHAQAGALLQVHQ 228
               D+G Y   A N  G     A LQV +
Sbjct: 25555 PEDTGYYRVTATNTAGSTSCQAHLQVER 25582



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 57/217 (26%), Positives = 83/217 (38%), Gaps = 30/217 (13%)

Query: 17    FPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALP 76
             F   + +  G    LK  + G     V W   G +L  SE   +   G++  L +  A  
Sbjct: 26739 FSTQMSINEGQRLVLKANIAGATD--VKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASH 26796

Query: 77    TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRS 136
              D G+  C ++   G       +T L    SD                  AP F++ PRS
Sbjct: 26797 RDEGILTCISKTKEGIVKCQYDLT-LSKELSD------------------APAFISQPRS 26837

Query: 137   QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRI 196
             Q +  G  V+ TC   G P P + W K+ + +     SS+ ++   R         +L I
Sbjct: 26838 QNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS---ISSNVSISRSR------NVYSLEI 26888

Query: 197   LAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               A + DSG Y   A+N  G   A A L V    E P
Sbjct: 26889 RNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEP 26925



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 81/369 (21%), Positives = 132/369 (35%), Gaps = 67/369 (18%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLA--ASERLSFPADGAEHGL 69
            P F+  P   + + G  A     V+G P P   W   GQQ+    + ++    DG +  L
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-SL 1469

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
            ++  A P+D+G +   A+N AG +  +  +TV          +  E  +         P+
Sbjct: 1470 IIVPATPSDSGEWTVVAQNRAGRSSISVILTV----------EAVEHQV--------KPM 1511

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
            F+   ++  +  G+ + +  RA G P P + W K+    D +    +    P    +G  
Sbjct: 1512 FVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS---DIIVPHKY----PKIRIEGTK 1564

Query: 190  ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPAD-----------PD 238
               AL+I +    DS  Y   A N  G       + V      P  +             
Sbjct: 1565 GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAK 1624

Query: 239  EAPAPVVEPLKCAPKTFWVNEG---------------------------KHAKFRCYVMG 271
            E  AP +EPL          EG                            H + R   +G
Sbjct: 1625 EIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIG 1684

Query: 272  KPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
             P   +EW  +G+P L    RL   +  G   L      ++D G+  C A N  G   ++
Sbjct: 1685 DPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTS 1743

Query: 332  VQLHVKEPR 340
              L VK+ +
Sbjct: 1744 ATLIVKDEK 1752



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 193/1091 (17%), Positives = 363/1091 (33%), Gaps = 146/1091 (13%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G++ +F   V  KP  E++W+  G   L +  ++ Y +  G   L++L C   D G Y  
Sbjct: 26083 GQNTRFILNVQSKPTAEVKWYHNGVE-LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRA 26141

Query: 320   AARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECK---VPNSRIPTAWFRE 376
                N  G+      L              DV G ++     + +   VP S  P     E
Sbjct: 26142 VCTNYKGEASDYATL--------------DVTGGDYTTYASQRRDEEVPRSVFPELTRTE 26187

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGI--YLCEMRGRVRTVA------------ 422
                +   +K  ++E  +  R +  ++    + +  Y       +++ A            
Sbjct: 26188 AYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTT 26247

Query: 423   ---NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ---SS 475
                  T+   IL + PR + V EGE+A    +T    V    W R G+ L    +   ++
Sbjct: 26248 RKIKTTLAARILTK-PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTT 26306

Query: 476   SGHMHALVLPGVTREDAGEVTFSLGNSR-------TTTLLRVKCVKHSPPGPPIL----- 523
             + +     +  V   D G  +  + NS        T T+ + +  + +   PP +     
Sbjct: 26307 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 26366

Query: 524   ----AEMFKGHKNTVLLTWKPPEPA----------PETPFIYRLERQEVGSEDWIQCFSI 569
                  E  K  K       K PEP+            TP   +++   V +   I  F  
Sbjct: 26367 RVKSPEAVKSPKRV-----KSPEPSHPKAVSPTETKPTP-TEKVQHLPVSAPPKITQFLK 26420

Query: 570   EKAGAVEVPGDCVPSEGDYRFRICTVSGHGR----SPHVVFHGSAHLVPTARLVAGLEDV 625
              +A        CV      R +  T    G+    + H  FH SA               
Sbjct: 26421 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSA--------------- 26465

Query: 626   QVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI--L 683
                   D  + L ++ + +      GE +     EG      L++  +     H  +  +
Sbjct: 26466 ------DGTYELKINNLTESD---QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 26516

Query: 684   HAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV 743
                K  D            +  A   I   PV +   QD    + + ++  V      R 
Sbjct: 26517 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 26576

Query: 744   DFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
                A W KDG+ + +     +  D     L + +    DSG + C  +  +     + + 
Sbjct: 26577 --TAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 26634

Query: 804   PPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQ----EVEESDFVVLENEG 859
                 I D          TSE       V +E+   +  +  +    E +  + + L+ E 
Sbjct: 26635 TIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEA 26694

Query: 860   PHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLT 919
                 +     + +     + +  +E    +    +V +     +    ++    +R+VL 
Sbjct: 26695 SKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLK 26754

Query: 920   CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESA-- 977
               +     +V+W  +G E+  S         + + L +      D G   C    +    
Sbjct: 26755 ANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIV 26813

Query: 978   ------SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVE 1030
                   + +  +++ P  I  PR +        + V+  CE+S E +P + W+K+ L + 
Sbjct: 26814 KCQYDLTLSKELSDAPAFISQPRSQNINEG---QNVLFTCEISGEPSPEIEWFKNNLPIS 26870

Query: 1031  ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLD 1090
              S  + + R      L +  A   D G++   A +     + T +     +V   +R + 
Sbjct: 26871 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 26930

Query: 1091  LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE 1150
             L     G   L+   +    Q+   K      +  +    +    +  ++         E
Sbjct: 26931 LR--TSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQE 26988

Query: 1151  YVCE------------TRHEAITFNVILAE----PPVQFLALETTPSPLCVAPGEPVVLS 1194
                E            T+ E+ T  ++ A     PP     +E  PS + +  G+ + ++
Sbjct: 26989 SFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPP----KIEALPSDISIDEGKVLTVA 27044

Query: 1195  CELSRAGAP-VVWSHNGRPVQEGEGLELHAEG--PRRVLCIQAAGPAHAGLYTCQSGAAP 1251
             C  +    P V WS  GR +   E    H E       L I        GLYT   G   
Sbjct: 27045 CAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEF 27104

Query: 1252  GAPSLSFTVQV 1262
             G+ S +  + +
Sbjct: 27105 GSDSATVNIHI 27115



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 60/241 (24%), Positives = 80/241 (33%), Gaps = 46/241 (19%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P  ++G ++  V+ G  V L C   G P PT+ W ++   ++   D      Q G A   
Sbjct: 897  PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIAR-- 953

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE---------------- 231
                  L I  A   DSG + C A N  G       L V    E                
Sbjct: 954  ------LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1007

Query: 232  -----------------SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                                A P E  AP         K     EG    F C V G P+
Sbjct: 1008 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV---EGGSVVFGCQVGGNPK 1064

Query: 275  PEIEWHWEGRPLLPD-RRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQ 333
            P + W   G PL    R ++ Y  + G   L +    A D G Y    RN  G+T ++  
Sbjct: 1065 PHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASAS 1124

Query: 334  L 334
            L
Sbjct: 1125 L 1125



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 69/279 (24%), Positives = 113/279 (40%), Gaps = 54/279 (19%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE----RLSFPADGAEH 67
           P F +  + V V+ G+ A  +  + G P P V W + GQ ++ S     ++SF    A+ 
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK- 64

Query: 68  GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            L + A    ++G Y  +A N +G+A + A + V    A                     
Sbjct: 65  -LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA--------------------P 103

Query: 128 PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
           P F+   +S  V +G++V L  R  G+P P + + +DG    E+  S  F +        
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGA---EIQSSLDFQISQ------ 154

Query: 188 PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
            G   +L I  A   DSG Y  +A N+ G A + A L V    E P            + 
Sbjct: 155 EGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVP-----------AKK 203

Query: 248 LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            K    T  ++E +  +         E +IE H++ R +
Sbjct: 204 TKTIVSTAQISESRQTRI--------EKKIEAHFDARSI 234



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 63/225 (28%), Positives = 91/225 (40%), Gaps = 30/225 (13%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD---GAEHG 68
             P F    R + V   + A L C V G P P+V W + G+++ A + L +      G  H 
Sbjct: 24623 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIA-DGLKYRIQEFKGGYHQ 24681

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
             L++ +    DA VY  RA N  G     A++ V           PA+  LP    G GA 
Sbjct: 24682 LIIASVTDDDATVYQVRATNQGGSVSGTASLEV---------EVPAKIHLPKTLEGMGA- 24731

Query: 129   VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                        LRG  V +     G P+P + W+K    +D   ++ H+ +   R+    
Sbjct: 24732 --------VHALRGEVVSIKIPFSGKPDPVITWQKGQDLID---NNGHYQVIVTRS---- 24776

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               SL       R  D+G YV  A+N  G  Q    L V   P+ P
Sbjct: 24777 FTSLVFPNGVER-KDAGFYVVCAKNRFGIDQKTVELDVADVPDPP 24820



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG-L 69
            PP FL+  +P+R   G  A  +  V+GEP P V W K  +QL  S   +   +    G  
Sbjct: 3766 PPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTF 3825

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVL 102
            ++      D+G+Y+C+A N  GE+  AA + VL
Sbjct: 3826 IVNDPQREDSGLYICKAENMLGESTCAAELLVL 3858



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 120/558 (21%), Positives = 202/558 (36%), Gaps = 73/558 (13%)

Query: 492   AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
             A E    +G     ++    C    PPGPP   ++    +++V L W  P      P   
Sbjct: 18672 AAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKG 18731

Query: 551   YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSA 610
             Y +E +E  +++W  C         +     +    +Y FRIC ++  G        GS 
Sbjct: 18732 YVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSV 18791

Query: 611   HLV-----PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEP 665
                     P   L A L  V V     A  +L L   I+G       E+K  + EG +  
Sbjct: 18792 VAQERIEPPEIELDADLRKVVVLR---ASATLRLFVTIKGR---PEPEVKWEKAEGILTD 18845

Query: 666   GALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVS 725
                R +IE       L++  V   DSG    ++     +S + T   +   + SP   V+
Sbjct: 18846 ---RAQIEVTSSFTMLVIDNVTRFDSGR---YNLTLENNSGSKTAFVNVRVLDSPSAPVN 18899

Query: 726   LTF--TTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAKVQD 782
             LT      + V L+ E   +D        G K+  +  +V K +  RK    +     + 
Sbjct: 18900 LTIREVKKDSVTLSWEPPLID-------GGAKI--TNYIVEKRETTRKAYATITNNCTKT 18950

Query: 783   SGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDREDAP 837
             +   E   EG S +F V   +      P    +P + V    +    V L  +V R  A 
Sbjct: 18951 TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVK-VSEPPLPPGRVTLV-DVTRNTAT 19008

Query: 838   VRWYK---DGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
             ++W K   DG        V ++ +G  +       +  +       AG+E  +    + +
Sbjct: 19009 IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNE 19068

Query: 895   -------------------VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
                                +   +  P     V A    ++ +  +  RP A V W KDG
Sbjct: 19069 KGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFK-GRPQATVNWRKDG 19127

Query: 936   EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT---------EP 986
             + + E+  + +    TV  L +     ED G Y   + + + S TV +T           
Sbjct: 19128 QTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPG 19187

Query: 987   PVRIIYPRDEVTLIAVTL 1004
             P+RI    DEV+  ++T+
Sbjct: 19188 PIRI----DEVSCDSITI 19201



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 75/318 (23%), Positives = 117/318 (36%), Gaps = 24/318 (7%)

Query: 43    VVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV- 101
             V W  G +QL  SE+     +     L +      D G Y C+  N  GE  + A + V 
Sbjct: 25295 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 25354

Query: 102   ----LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
                 +        ++  +R   +    E  P F     ++    G  V         PEP
Sbjct: 25355 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 25414

Query: 158   TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
              + W K G  +    +   +  +  +          L I +    D   Y   ARN +G 
Sbjct: 25415 HVTWYKSGQKIKPGDNDKKYTFESDKG------LYQLTINSVTTDDDAEYTVVARNKYGE 25468

Query: 218   AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
                 A L V   P  PP D    P       K         EG+   F   V G P P +
Sbjct: 25469 DSCKAKLTVTLHP--PPTDSTLRPM-----FKRLLANAECQEGQSVCFEIRVSGIPPPTL 25521

Query: 278   EWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             +W  +G+PL L     +++   D  + L +     +D G Y   A N+AG T  + Q H+
Sbjct: 25522 KWEKDGQPLSLGPNIEIIHEGLD-YYALHIRDTLPEDTGYYRVTATNTAGST--SCQAHL 25578

Query: 337   KEPRLRFTRPLQDVEGRE 354
             +  RLR+ +  Q+ + +E
Sbjct: 25579 QVERLRYKK--QEFKSKE 25594



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 144/696 (20%), Positives = 245/696 (35%), Gaps = 128/696 (18%)

Query: 252   PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
             P++  V EG+ A+F C   G+P P + W  +G+ L    R  +   +      ++   QA
Sbjct: 26262 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKS-TFEISSVQA 26320

Query: 312   KDRGLYVCAARNSAGQTLSAVQLHVKEPRL---------RFTRPLQDVEGREHGIAVLEC 362
              D G Y     NS G+  +   L +++ R+         R   P   V+  E   +    
Sbjct: 26321 SDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRV 26380

Query: 363   KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
             K P    P A    + +  P  K + +      + I   LKA+             + +A
Sbjct: 26381 KSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPK-ITQFLKAEAS-----------KEIA 26428

Query: 423   NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHM--- 479
              +T                  E++VL  +      E  W +DG++L       +GH    
Sbjct: 26429 KLT---------------CVVESSVLRAK------EVTWYKDGKKL-----KENGHFQFH 26462

Query: 480   ------HALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKG 529
                   + L +  +T  D GE    +    G S+T      +  K        ++E  K 
Sbjct: 26463 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKS 26522

Query: 530   HKNTVLLTW------KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE------V 577
              + T   T       K PEP    P I    +    S D +  F+++  G          
Sbjct: 26523 DQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK 26582

Query: 578   PGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSL 637
              G  +   G Y+                F    H   T+   +GL    V +   +V S 
Sbjct: 26583 DGKAITQGGKYKL---------SEDKGGFFLEIHKTDTSD--SGLYTCTVKNSAGSVSSS 26631

Query: 638   DLSTI--IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH---------AV 686
                TI  I+ T        K++E   Q +   ++  I QK L+   I           A+
Sbjct: 26632 CKLTIKAIKDTEAQKVSTQKTSEITPQ-KKAVVQEEISQKALRSEEIKMSEAKSQEKLAL 26690

Query: 687   KHQDSGALVGFSCPGVQDSAALTIQESPVH-------ILSPQDR---------VSLTFTT 730
             K + S  L+      V+ SAA ++++S VH         S + R           ++   
Sbjct: 26691 KEEASKVLIS---EEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINE 26747

Query: 731   SERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC-- 788
              +R+VL   ++       W  +G ++  SE     + G    L + +A  +D G   C  
Sbjct: 26748 GQRLVLKANIAGAT-DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCIS 26806

Query: 789   -RTEG-VSAFFGVT----VQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWY 841
                EG V   + +T    + D P  I  PR     +    + V+  CE+  E +P + W+
Sbjct: 26807 KTKEGIVKCQYDLTLSKELSDAPAFISQPRSQ---NINEGQNVLFTCEISGEPSPEIEWF 26863

Query: 842   KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEF 877
             K+   +  S  V +        L +     SD G++
Sbjct: 26864 KNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 26899



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/115 (27%), Positives = 50/115 (43%)

Query: 9     GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
             G  P   +  + V    G  A+L C ++G P P + W + G++L  S +    +DG  H 
Sbjct: 24225 GEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT 24284

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGS 123
             L +      D GVY C A N  GE   ++ + +   P   P     E+   + GS
Sbjct: 24285 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGS 24339



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 81/379 (21%), Positives = 133/379 (35%), Gaps = 82/379 (21%)

Query: 131   LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD--------------------- 169
             LT PRS  V  G     +C   G P PT+ W + G  L                      
Sbjct: 26259 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 26318

Query: 170   EVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGV-YVCHARNAHGHAQAGALLQVHQ 228
             +  D  ++++    +E    A   L I  AR+ +  V      ++     ++   ++  +
Sbjct: 26319 QASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPK 26378

Query: 229   PPESP-PADP------DEAPAPVVE----PLKCAPK--TFWVNEGKH--AKFRCYVMGK- 272
               +SP P+ P      +  P P  +    P+   PK   F   E     AK  C V    
Sbjct: 26379 RVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSV 26438

Query: 273   -PEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
                 E+ W+ +G+ L  +     +   DG + LK+      D+G YVC      G + + 
Sbjct: 26439 LRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTN 26498

Query: 332   VQ--------LHVKEPRL----------------RFTRP---------------LQDVEG 352
             +Q        +H K  ++                R T P               LQD   
Sbjct: 26499 LQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTV 26558

Query: 353   REHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL 411
                 +A    K      PTA W ++ + +    KY+  E+     L IH+    D G+Y 
Sbjct: 26559 SSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYT 26618

Query: 412   CEMR---GRVRTVANVTVK 427
             C ++   G V +   +T+K
Sbjct: 26619 CTVKNSAGSVSSSCKLTIK 26637



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 44/164 (26%), Positives = 77/164 (46%), Gaps = 10/164 (6%)

Query: 1366 LTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPG--PQVEMAQNGSSRILTLRGCQ 1422
            L  + V EG  ATF   +S  P  +V+W R+G V++    P V+++ +     LT+    
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVT 71

Query: 1423 LGDAGTVTLRA----GSTATSARLHVRETELL--FLRRLQDVRAEEGQDVCLEVETGRVG 1476
              ++G  +L+A    G   ++A L V+       F++RLQ +   +G  V L+V    + 
Sbjct: 72   KANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIP 131

Query: 1477 AAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
                V++ R G  +       ++Q+G ++ L I      D GTY
Sbjct: 132  TP-VVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTY 174



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 12/141 (8%)

Query: 1020 VRWYKDGLEVEESE--ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV--- 1074
            V W++DG  +  S    + +     R +L +PA    + G +   A + S   T T    
Sbjct: 37   VSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELL 96

Query: 1075 ----TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
                TAPP  +     +S+ +  G+  R+++R    P    V++Y+DG E+++S   Q+ 
Sbjct: 97   VKAETAPPNFVQR--LQSMTVRQGSQVRLQVRVTGIPT-PVVKFYRDGAEIQSSLDFQIS 153

Query: 1131 AEGPTRTLTLPHAQPEDAGEY 1151
             EG   +L +  A PED+G Y
Sbjct: 154  QEGDLYSLLIAEAYPEDSGTY 174



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 71/338 (21%), Positives = 130/338 (38%), Gaps = 44/338 (13%)

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
             G+   L I  A   D G+  C ++   G  +    L + +       +  +APA + +P 
Sbjct: 26784 GSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSK-------ELSDAPAFISQP- 26835

Query: 249   KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
                 ++  +NEG++  F C + G+P PEIEW     P+       + R R+  + L++  
Sbjct: 26836 ----RSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRN-VYSLEIRN 26890

Query: 309   CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
                 D G Y   A+N  GQ  +   L V         P ++V  R  G   L+    +  
Sbjct: 26891 ASVSDSGKYTIKAKNFRGQCSATASLMVLP---LVEEPSREVVLRTSGDTSLQGSFSSQS 26947

Query: 369   IPTAWFREDQRL----------LPCRKYEQIEE---GTVRRLIIHRLKADDDGI-YLCEM 414
             +  +  +++             +   K+  +      +++   +    +   GI  + ++
Sbjct: 26948 VQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQL 27007

Query: 415   RGRVRTVANVTVKG--PILKRLPRKLDVLEGE-NAVLLVETLEAGVEGRWSRDGEELPVI 471
                   +    ++G  P ++ LP  + + EG+   V    T E   E  WS  G +   I
Sbjct: 27008 ESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRK---I 27064

Query: 472   CQSSSGHMH--------ALVLPGVTREDAGEVTFSLGN 501
                  G  H         L++  V ++D G  T SLGN
Sbjct: 27065 HSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 27102



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 97/418 (23%), Positives = 155/418 (37%), Gaps = 52/418 (12%)

Query: 373  WFREDQRLLPCRKYEQIEEGTVR-RLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
            W R + R +   K++ +EEG V  +  + R++A    +    +        NV  K P  
Sbjct: 8026 WMRVNSRPIKDLKFK-VEEGVVPDKEYVLRVRA----VNAIGVSEPSEISENVVAKDPDC 8080

Query: 432  KRL----PRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHA---LV 483
            K         + V+EGE   + V      V    W +DG+E+    + +  + H    L 
Sbjct: 8081 KPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLE 8140

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP 543
            +P   R DAG  T +L N   +    +       PGP    +     K++  LTW+PPE 
Sbjct: 8141 VPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEF 8200

Query: 544  APETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
               TP + Y LER+E G   +I   S E   +  V  D +P+ G+Y FR+  V+  G   
Sbjct: 8201 DGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVK-DLIPN-GEYFFRVKAVNKVGGGE 8258

Query: 603  HVVFHGSAHLV----------------PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG- 645
            ++                         PTA  +       +YDG   +    +  I +G 
Sbjct: 8259 YIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGE 8318

Query: 646  -TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD 704
              W    E L             L Y    KGL+           ++ A +         
Sbjct: 8319 ERWKRCNEHLVP----------ILTY--TAKGLEEGKEYQFRVRAENAAGISEPSRATPP 8366

Query: 705  SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESEL 761
            + A+   ++P  IL    R SL     + + L   +S   +P  TW KD   +   E+
Sbjct: 8367 TKAVDPIDAPKVIL----RTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEI 8420



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 24/209 (11%)

Query: 413   EMRGRVRTVANVTVKGP-------ILKRLPRKLDVLEGENAVLLVET-----LEAGVEGR 460
             + R   RT  N++           + + +P ++D+     ++L V+      L+A V G+
Sbjct: 12958 QFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGK 13017

Query: 461   ------WSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 511
                   W +DG  L     I  +   ++  L L  V R+D+G+ T +  NS  +    +K
Sbjct: 13018 PMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIK 13077

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPP-EPAPETPFIYRLERQEVGSEDWIQCFSIE 570
                   PGPP   ++ K + +  +L+W+PP E        Y ++++E    +W Q  +  
Sbjct: 13078 LKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATV 13137

Query: 571   KAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                +  V  + +    +Y+FRIC  + +G
Sbjct: 13138 PITSCSV--EKLIEGHEYQFRICAENKYG 13164



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 100/471 (21%), Positives = 191/471 (40%), Gaps = 59/471 (12%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G+ A+  C ++G+P P+I+W+  G+ L+  R+  M  D      L V+  + +D G+Y C
Sbjct: 24242 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSD-GRTHTLTVMTEEQEDEGVYTC 24300

Query: 320   AARNSAGQTLSAVQLHVK-EPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFRED 377
              A N  G+  ++ +L ++  P+     PL++   G       L        +P   +   
Sbjct: 24301 IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHG 24360

Query: 378   QRLLPCRKYEQIEE-----GTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKG-PIL 431
             Q+LL   +   IE        V + +  +  A    + L  + G V  + +V ++  P  
Sbjct: 24361 QKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDK 24420

Query: 432   KRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVT--- 488
                P  ++ L   +AV+  +   A   G W  +   +   C++  G    LV   ++   
Sbjct: 24421 PTGPIVIEALLKNSAVISWKP-PADDGGSWITN--YVVEKCEAKEGAEWQLVSSAISVTT 24477

Query: 489   ------REDAG-------EVTFSLGNS---RTTTLLRVKCVKHSPPGPPILAEMFKGHKN 532
                    E+AG       + TF + +     +  +++    K   PG P +  +    K+
Sbjct: 24478 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAV---TKD 24534

Query: 533   TVLLTWKPPEPAPETPF-IYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DYRF 590
             + ++ WKPP          Y LE++E     WI   + E    V    + +  EG +Y F
Sbjct: 24535 SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLI--EGLEYEF 24592

Query: 591   RICTVSGHGRS-----PHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS----T 641
             R+   +  G S        +   S   +        L ++ V    +A     ++     
Sbjct: 24593 RVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKP 24652

Query: 642   IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQ-KGLQHRLILHAVKHQDS 691
             I++  W+  G+E+ ++          L+YRI++ KG  H+LI+ +V   D+
Sbjct: 24653 IVK--WYRQGKEIIAD---------GLKYRIQEFKGGYHQLIIASVTDDDA 24692



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 54/214 (25%), Positives = 86/214 (40%), Gaps = 27/214 (12%)

Query: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD-EVWDSSHFALQPGRAE 185
           AP F    +S  VL G+         G P P + W +DG  +          +   GRA+
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64

Query: 186 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
                   L I A    +SG Y   A N  G A + A L V           + AP   V
Sbjct: 65  --------LTIPAVTKANSGRYSLKATNGSGQATSTAELLV---------KAETAPPNFV 107

Query: 246 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 305
           + L    ++  V +G   + +  V G P P ++++ +G  +   +  L ++    G +  
Sbjct: 108 QRL----QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI---QSSLDFQISQEGDLYS 160

Query: 306 VLYCQA--KDRGLYVCAARNSAGQTLSAVQLHVK 337
           +L  +A  +D G Y   A NS G+  S  +L V+
Sbjct: 161 LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 81/338 (23%), Positives = 134/338 (39%), Gaps = 47/338 (13%)

Query: 700  PGVQDSAALTIQESPVHILSPQDRVSLTF--TTSERVVLTCELSRVDFPA-TWYKDGQKV 756
            P +Q  A  ++QE        Q    +T     S+ ++ T E+S  +  +   Y D   V
Sbjct: 4322 PRIQQGAKTSLQEEMDSFSGSQKVEPITEPEVESKYLISTEEVSYFNVQSRVKYLDATPV 4381

Query: 757  EESELLVVKMDGRKHRLILP----EAKVQDSGEFECRTEGVSAFFGVTVQD--PPVH--I 808
             +     V  D ++   + P    E    +SG  E  T  +    G  +++  P +H  +
Sbjct: 4382 TKGVASAVVSDEKQDESLKPSEEKEESSSESGTEEVATVKIQEAEGGLIKEDGPMIHTPL 4441

Query: 809  VDP--REHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESD-FVVLENEGPHRRLV 865
            VD    E   VH  TS  +  A EV+       WY + + V   + F  L+++  +  ++
Sbjct: 4442 VDTVSEEGDIVHLTTS--ITNAKEVN-------WYFENKLVPSDEKFKCLQDQNTYTLVI 4492

Query: 866  LPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVL------T 919
                     GE+ C A ++      T T     +V  +  V    +    V L      T
Sbjct: 4493 DKVNTEDHQGEYVCEALNDSGK---TATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFT 4549

Query: 920  CEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE--- 975
            CE+   P    +W K G E+ ES    ++    +  L +   Q+ D GEY C+  +E   
Sbjct: 4550 CEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGS 4609

Query: 976  -SASFTVTVTEP----------PVRIIYPRDEVTLIAV 1002
             S + T+TVT P          P R   P++EV L +V
Sbjct: 4610 VSCTATLTVTVPGGEKKVRKLLPERKPEPKEEVVLKSV 4647



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 34/119 (28%), Positives = 55/119 (46%), Gaps = 9/119 (7%)

Query: 7     DQGSPPCFLRFPR---PVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD 63
             D+  PP     P+    + V +G   ++   + G+P P + W KG Q+L+ + RL   + 
Sbjct: 16231 DEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKST 16290

Query: 64    GAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
                  L +  A+  D+G Y+ +A+N AGE      V VL+ P       P E P+   G
Sbjct: 16291 DFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG------PPEGPVVISG 16343



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 28/92 (30%), Positives = 48/92 (52%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
           +PP F++  + + V  G++  L+  V G P PVV + + G ++ +S       +G  + L
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSL 161

Query: 70  LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
           L+  A P D+G Y   A N+ G A + A + V
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 195/938 (20%), Positives = 327/938 (34%), Gaps = 198/938 (21%)

Query: 713  SPVHI-LSPQDRVS----LTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKM 766
            +PV I ++P   VS    +T    E V L C +S    P  TWY++  ++E S    +  
Sbjct: 888  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 767  DGRKHRLILPEA-------------------------KVQDSGEFECRTEGVSAFFGVT- 800
                 RL++ EA                          VQ S EFE  T  V+  F    
Sbjct: 948  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1007

Query: 801  ---VQDPPVHIVD---------PREHVFVHAITSECV---------MLACEVDREDAP-V 838
               V+   V + D         P E    + IT   V         +  C+V     P V
Sbjct: 1008 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV 1067

Query: 839  RWYKDGQEVEESDF--VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI---- 892
             W K G  +       V    +    +LV+  T   D GE+  V  ++    + +     
Sbjct: 1068 YWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLE 1127

Query: 893  -----------------TDVSSWIVYPS------GKVYVAAVR---LERVVLTCELCRPW 926
                             T V++++  P       G VY    +    E+ ++  ++ +  
Sbjct: 1128 EADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDT 1187

Query: 927  AEVR-WTKDGEEVVESPALLLQKEDTVRRLVLPAVQL-EDSGEYLCEIDDESASFTVTVT 984
              VR + +D E  + S    L KE   R +     +L E+ GE    +D   +    +  
Sbjct: 1188 VVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGF 1247

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLE--RDG 1041
            +  ++     + +         V   C++S    P + WYKDG  ++  E   ++  +DG
Sbjct: 1248 DSRIKNYRILEGMG--------VTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1299

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             R  L +P   PED G +   A +             +  V PAA       GAP  +  
Sbjct: 1300 -RASLRIPVVLPEDEGIYTAFASNIKG----NAICSGKLYVEPAA-----PLGAPTYIPT 1349

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
               V+   S          +  S A    A      ++     P    E   E++ E + 
Sbjct: 1350 LEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERL- 1408

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV---VWSHNGRP-VQEGE 1217
            +  +    PV F  LE   +              +L   G P+    W H+G+  V +  
Sbjct: 1409 YKPVFVLKPVSFKCLEGQTARF------------DLKVVGRPMPETFWFHDGQQIVNDYT 1456

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYT--CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
               +  E   + L I  A P+ +G +T   Q+ A   + S+  TV+  E  V+ +  E  
Sbjct: 1457 HKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKL 1516

Query: 1276 QTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA--SQGRVQLEQAGARQVLRVQGAR 1332
            +  V    G  LE+ V  +G P   + W K+ + +      ++++E       L++    
Sbjct: 1517 K-NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTV 1575

Query: 1333 SGDAGEY----LCDAPQDSRIFLVSVE-----------------------------EPLL 1359
            S D+  Y    +  A +D+    V+VE                             EPL 
Sbjct: 1576 SQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLH 1635

Query: 1360 VKLVSE---------------------LTPLTVHEGDDATFRCEVSP---PDADVTWLRN 1395
            ++   E                     LT L +     A F C ++P   P   V WL +
Sbjct: 1636 LRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHD 1695

Query: 1396 GAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLF 1451
            G  +    ++ M        L        D+G +T RA    G+  TSA L V++ + L 
Sbjct: 1696 GKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSL- 1754

Query: 1452 LRRLQDVRAEEGQDVCLEV-ETGRVGAAGAVRWVRGGQ 1488
               +++ +  EG+     + E  R+   GA+  V   Q
Sbjct: 1755 ---VEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQ 1789



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 67/309 (21%), Positives = 111/309 (35%), Gaps = 55/309 (17%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA----------EDGP 188
            +L G  V   C+  G P P + W KDG  +          LQ GRA          ++G 
Sbjct: 1256 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1315

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ----PPESPPADPDEAPAPV 244
              + A  I    +    +YV  A           L  V +     P S    P       
Sbjct: 1316 YTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR 1375

Query: 245  VEPLKCAPK----------------------------------TFWVNEGKHAKFRCYVM 270
            + P + +P                                   +F   EG+ A+F   V+
Sbjct: 1376 MSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVV 1435

Query: 271  GKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLS 330
            G+P PE  W  +G+ ++ D    +    DG   L ++     D G +   A+N AG++  
Sbjct: 1436 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1495

Query: 331  AVQLHVK----EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRK 385
            +V L V+    + +  F   L++V  +E     ++ +   +  P   W +    ++P  K
Sbjct: 1496 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVP-HK 1554

Query: 386  YEQIE-EGT 393
            Y +I  EGT
Sbjct: 1555 YPKIRIEGT 1563



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 1/93 (1%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            +++++G    +  VV G P P  VW K   +L   +R+     G +  L++  AL  D G
Sbjct: 8809 IQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELD-KDRVVIDNVGTKSELIIKDALRKDHG 8867

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
             YV  A N+ G  +AAA V V + P    +L+P
Sbjct: 8868 RYVITATNSCGSKFAAARVEVFDVPGPVLDLKP 8900



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 1/105 (0%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             S +    P F+  PR   +  G      C + GEP P + W K    ++ S  +S     
Sbjct: 26822 SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR 26881

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP 109
               + L +  A  +D+G Y  +A+N  G+  A A++ VL P   +P
Sbjct: 26882 NVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL-PLVEEP 26925



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 45/157 (28%), Positives = 63/157 (40%), Gaps = 16/157 (10%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + V + +GA   L   V G PPPV+ W K G  LA+  R       +   L++      D
Sbjct: 23149 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYD 23206

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS-------PGSGEGAPV-- 129
             AG Y   A N +G+  A   V V + P   P ++  E    S       P    GAPV  
Sbjct: 23207 AGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNN 23266

Query: 130   FLTGPRSQWVLRGAEVVLTC-----RAGGLPEPTLYW 161
             ++   R   +     V   C     R  GL E T+Y+
Sbjct: 23267 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYY 23303



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 13/178 (7%)

Query: 1640 VTEGDTATFECELSQ-ALADVTWEKDGNALTPS--PRLRLQALGTRRLLQLRRCGPSDAG 1696
            V EG TATFE  +S   + +V+W +DG  ++ S  P +++     R  L +     +++G
Sbjct: 17   VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76

Query: 1697 TYSCAV--GTARA-GPVRLTVRERTVA--VLSELRSVSAREGDGATFECTVSEVET-TGR 1750
             YS     G+ +A     L V+  T     +  L+S++ R+G     +  V+ + T   +
Sbjct: 77   RYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVK 136

Query: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVE 1804
            +   G  ++     +I QEG  + L+++E   ED+G     A    G A S A L V+
Sbjct: 137  FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 4/97 (4%)

Query: 11    PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
             PP F        V++G + ++    +G P P V W K    L  + R++  A+  E+  L
Sbjct: 15842 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN--AESTENNSL 15899

Query: 71    LTA--ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             LT   A   D G YV +  N+AGEA     V VL+ P
Sbjct: 15900 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15936



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 58/264 (21%), Positives = 108/264 (40%), Gaps = 22/264 (8%)

Query: 1631  IVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRR 1689
             IV G  D  V+    A F  + + +      W KDG A+T   + +L        L++ +
Sbjct: 26549 IVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHK 26608

Query: 1690  CGPSDAGTYSCAVGTARAGPVRLTVRERTVAVL-SELRSVSAREGDGATFECTVSEVETT 1748
                SD+G Y+C V  + AG V  + +    A+  +E + VS ++    T E T  + +  
Sbjct: 26609 TDTSDSGLYTCTVKNS-AGSVSSSCKLTIKAIKDTEAQKVSTQK----TSEIT-PQKKAV 26662

Query: 1749  GRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE--DAGEVRFQAGPAQSLALLEVEAL 1806
              + E+  + LR    +++ +   +  L L E  ++   + EV+  A  +   +++  E  
Sbjct: 26663 VQEEISQKALR-SEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEIT 26721

Query: 1807  PLQMCRHPPR----------EKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEM 1856
                      R          + ++  G+R VL+  ++     V W+  G EL   ++Y  
Sbjct: 26722 KTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDVKWVLNGVELTNSEEYRY 26780

Query: 1857  RSHGPTHSLVIHDVRPEDQGTYCC 1880
                G   +L I      D+G   C
Sbjct: 26781 GVSGSDQTLTIKQASHRDEGILTC 26804



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 180/863 (20%), Positives = 317/863 (36%), Gaps = 125/863 (14%)

Query: 228   QPPESPPADP--DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
             +P ES  A    DE   P +        T  V+ G+  K    + GKP P I+W  +G  
Sbjct: 16219 EPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWI-KGDQ 16277

Query: 286   LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV--------- 336
              L +  RL  +  D    L V      D G Y+  A+N AG+    V + V         
Sbjct: 16278 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16337

Query: 337   ---------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYE 387
                      ++  L +  PLQD  G    I  +  +   SR+       + + L C+  +
Sbjct: 16338 PVVISGVTAEKCTLAWKPPLQD--GGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16395

Query: 388   QIE--EGTVRRLIIHRLKADDD---------GIYLCEMRGRVRTVANVTVKGPILKRLPR 436
              +E  E T R + +++    +            ++     +   V  VT    I+     
Sbjct: 16396 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVW--- 16452

Query: 437   KLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHALVLPGVTRED---- 491
             +    +G + +L     +   EG RW+R  + L        G +   V   +   D    
Sbjct: 16453 ERPASDGGSEILGYVLEKRDKEGIRWTRCHKRL-------IGELRLRVTGLIENHDYEFR 16505

Query: 492   -AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP--EPAPETP 548
              + E    L      +  +  C     PGPP   ++    +++V L+W  P  +   E  
Sbjct: 16506 VSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQ 16565

Query: 549   FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHG 608
               Y +E+ +V   +W  C          +  + +  + +Y FRIC ++  G   H    G
Sbjct: 16566 G-YIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPG 16624

Query: 609   SAHLVPTARLVAGLEDVQV----YDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
                ++   +L A   D+ +         A  SL L   I+G       E+K  + +G++ 
Sbjct: 16625 P--IIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGR---PTPEVKWGKVDGEIR 16679

Query: 665   PGALRYRIEQKGLQHRLILHAVKHQDSG--ALVGFSCPGVQDSAALTIQ--ESPVHILSP 720
               A+   I+       L+L  V   DSG   L   +  G + SA +T++  ++P    SP
Sbjct: 16680 DAAI---IDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTK-SAFVTVRVLDTP----SP 16731

Query: 721   QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAK 779
                + +T  T + V +T E   +D        G K++    +V K +  RK    +    
Sbjct: 16732 PVNLKVTEITKDSVSITWEPPLLD-------GGSKIK--NYIVEKREATRKSYAAVVTNC 16782

Query: 780   VQDSGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDRE 834
              ++S + +   EG S +F VT ++      P    DP +   V     +  +   +V R 
Sbjct: 16783 HKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGK--ITVDDVTRN 16840

Query: 835   DAPVRWYK----DGQEVEESDFVVLENEGPH----------RRLVLPATQPSDGGE--FQ 878
                + W K     G ++ +    ++E +  H          + L    T  + G E  F+
Sbjct: 16841 SVSLSWTKPEHDGGSKIIQ---YIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFR 16897

Query: 879   CVAGDE--------CAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVR 930
              VA +E         A   V    V    V P+   Y   V  +  +      RP   + 
Sbjct: 16898 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 16957

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY----LCEIDDESASFTVTVTEP 986
             WTKDG  + ++  + +     +  L +     +D G+Y       +  ++AS  +   + 
Sbjct: 16958 WTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 17017

Query: 987   PVRIIYPRDEVTLIAVTLECVVL 1009
             P     P+  V    V+ E + L
Sbjct: 17018 PDP---PKGPVKFDDVSAESITL 17037



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 44/198 (22%), Positives = 77/198 (38%), Gaps = 24/198 (12%)

Query: 1100  ELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHE 1158
             +L C++       ++WY+ G E+  S   ++ ++G T TLT+   + ED G Y C     
Sbjct: 24246 QLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC----- 24300

Query: 1159  AITFNVILAEPPVQFLALETTPSPLCVAPGEPV----------VLSCELSRAGAPV---V 1205
              I  N +        L L+ TP      PG P+           L   +   G PV    
Sbjct: 24301 -IATNEVGEVETSSKLLLQATPQ---FHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 24356

Query: 1206  WSHNGRPVQEGEGLEL-HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
             W H  + +Q  E + + + E    ++        HAG Y  Q     G       V++ +
Sbjct: 24357 WFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 24416

Query: 1265  PPVRVVAPEAAQTRVRST 1282
              P +   P   +  ++++
Sbjct: 24417 KPDKPTGPIVIEALLKNS 24434



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 40/149 (26%), Positives = 68/149 (45%), Gaps = 13/149 (8%)

Query: 925  PWAEVRWTKDGEEVVES--PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVT 982
            P  EV W +DG+ +  S  P + +   D   +L +PAV   +SG Y  +  + S   T T
Sbjct: 33   PVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATST 92

Query: 983  V-------TEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEA 1034
                    T PP   +     +T+   +   V L   ++    PV ++Y+DG E++ S  
Sbjct: 93   AELLVKAETAPP-NFVQRLQSMTVRQGSQ--VRLQVRVTGIPTPVVKFYRDGAEIQSSLD 149

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
              + ++G    L++  A PED G +  +A
Sbjct: 150  FQISQEGDLYSLLIAEAYPEDSGTYSVNA 178



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 75/330 (22%), Positives = 128/330 (38%), Gaps = 32/330 (9%)

Query: 516  SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIE-KAG 573
            SPP PP+   +    +  + + WKPPE    +P I Y +E   VG+E W++  S   K  
Sbjct: 7978 SPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDL 8037

Query: 574  AVEVPGDCVPSEGDYRFRICTVSGHGRS-PHVVFHGSAHLVPTARLVAGLE--DVQVYDG 630
              +V    VP + +Y  R+  V+  G S P  +        P  +    LE  D+ V +G
Sbjct: 8038 KFKVEEGVVPDK-EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEG 8096

Query: 631  EDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKH 688
            E     +    +   T  W  +G+E+K+++          R  ++   +   L +     
Sbjct: 8097 EKLSIPVPFRAVPVPTVSWHKDGKEVKASD----------RLTMKNDHISAHLEVPKSVR 8146

Query: 689  QDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD--FP 746
             D+G +   +      SA  +I    + +  P   +  +  T     LT E    D   P
Sbjct: 8147 ADAG-IYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTP 8205

Query: 747  ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFG-------- 798
               Y   ++       +  M G +++L      +  +GE+  R + V+   G        
Sbjct: 8206 ILHYVLERREAGRRTYIPVMSG-ENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8264

Query: 799  -VTVQDPPVHIVDPREHVFVHAITSECVML 827
             V  QDP     DP   V VH  T+E + +
Sbjct: 8265 PVIAQDPK-QPPDPPVDVEVHNPTAEAMTI 8293



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 40/81 (49%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G   +++  VLG P P V W+KG Q L  ++R++F        L +   + +D+G Y  
Sbjct: 14774 AGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPL 14833

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
              ARN  GE      + V + P
Sbjct: 14834 TARNIVGEVGDVITIQVHDIP 14854



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 127/603 (21%), Positives = 215/603 (35%), Gaps = 98/603 (16%)

Query: 37    GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
             G P   V W K GQ L  + R++  +      L +  A   D G Y     N+AG     
Sbjct: 19115 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 19174

Query: 97    AAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQWVLRGAEVVLTCRAGGLP 155
               + VL+ P     ++  E    S       P +  G + S +++   E   T       
Sbjct: 19175 ITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTT------ 19228

Query: 156   EPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVY---VCHAR 212
                  W     A+                     A  +++I+  RL     Y   VC A 
Sbjct: 19229 -----WHIVSQAV---------------------ARTSIKIV--RLTTGSEYQFRVC-AE 19259

Query: 213   NAHG---HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFW---VNEGKHAKFR 266
             N +G   ++++ A+  V + P SPP  P      VV   K      W   VN+G      
Sbjct: 19260 NRYGKSSYSESSAV--VAEYPFSPPGPP--GTPKVVHATKSTMLVTWQVPVNDGGSRVIG 19315

Query: 267   CYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA------ 320
              ++  K    I W    + L+ D + +     D G + +         G+  C+      
Sbjct: 19316 YHLEYKERSSILWSKANKILIADTQ-MKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPV 19374

Query: 321   -ARNSA---GQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRE 376
              AR+     GQ      +  K   L++++P  D   +  G  V   ++P           
Sbjct: 19375 PARDPCDPPGQP-EVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELP----------- 19422

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-GPILKR-- 433
             D R L C  Y  I+E       +  L  D    +    R    +V+  +   GPI+ +  
Sbjct: 19423 DGRWLKCN-YTNIQETYFE---VTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDD 19478

Query: 434   --LPRKLDVLEGENAVLL----VETLEAGVEGR------WSRDGEELPVICQS---SSGH 478
                PR +  ++  + +++    V  + A + GR      W++DG E+    ++   S+ +
Sbjct: 19479 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN 19538

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLT 537
                L +    R D G+   +L N   T  + V C     PGPP       G       L+
Sbjct: 19539 HTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 19598

Query: 538   W-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS 596
             W +P E        Y +E++E     W  C    +  + +V    +    +Y FR+  V+
Sbjct: 19599 WGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTK--LLKGNEYIFRVTGVN 19656

Query: 597   GHG 599
              +G
Sbjct: 19657 KYG 19659



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 24/85 (28%), Positives = 43/85 (50%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             V + +G++  L   V G+P P ++W KG ++L   E++S    G     ++     +D+G
Sbjct: 22752 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSG 22811

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y    +NA+G    +  V VL+ P
Sbjct: 22812 KYTLTVKNASGTKAVSVMVKVLDSP 22836



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 87/433 (20%), Positives = 168/433 (38%), Gaps = 45/433 (10%)

Query: 516   SPPGPPILA-EMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAG 573
             +PP PP    E+    K++V L+W +P +        Y +ER+E  ++ W++    +   
Sbjct: 24022 NPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 24081

Query: 574   AVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLE--DVQVYDGE 631
              +      VP + +Y+FRI   +  G S            P +  V   +  D     GE
Sbjct: 24082 TMYTVTGLVP-DAEYQFRIIAQNDVGLS---------ETSPASEPVVCKDPFDKPSQPGE 24131

Query: 632   DAVFSLDLSTII--------QGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLIL 683
               + S+   ++          G   + G  ++  +        + + RI+ K      +L
Sbjct: 24132 LEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLL 24191

Query: 684   HAVKHQD---SGALVGFSCP---GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
              A +++    +    G S P    +     LT  E+P      +D   +T    E   L+
Sbjct: 24192 EATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD---VTTKLGEAAQLS 24248

Query: 738   CELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC----RTEG 792
             C++     P   WY+ G+++ +S    +  DGR H L +   + +D G + C        
Sbjct: 24249 CQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGE 24308

Query: 793   VSAFFGVTVQ-DPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESD 851
             V     + +Q  P  H   P +  +  A+ S   +    + R    + W+   + ++ S+
Sbjct: 24309 VETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSE 24368

Query: 852   FVVLENEGPHRRLVLPATQ-PSDGGEFQC----VAGDECAYFTVTITDVSSWIVYPSGKV 906
              + +EN   +  LV+   Q  +  G+++     V G   A   V I D       P+G +
Sbjct: 24369 NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPD---KPTGPI 24425

Query: 907   YVAAVRLERVVLT 919
              + A+     V++
Sbjct: 24426 VIEALLKNSAVIS 24438



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 42/188 (22%), Positives = 74/188 (39%), Gaps = 10/188 (5%)

Query: 1638  LEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             + + EG     +  ++ A  DV W  +G  LT S   R    G+ + L +++    D G 
Sbjct: 26743 MSINEGQRLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGI 26801

Query: 1698  YSCAVGTARAGPVR----LTVRER---TVAVLSELRSVSAREGDGATFECTVS-EVETTG 1749
              +C +   + G V+    LT+ +      A +S+ RS +  EG    F C +S E     
Sbjct: 26802 LTC-ISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEI 26860

Query: 1750  RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
              W     P+   + V I +    + L +      D+G+   +A   +         + L 
Sbjct: 26861 EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP 26920

Query: 1810  MCRHPPRE 1817
             +   P RE
Sbjct: 26921 LVEEPSRE 26928



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 2/100 (2%)

Query: 8    QGSPPCFL--RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA 65
            Q +P  FL  +    + V +G + EL   V G+P P + W K    L   +R++      
Sbjct: 7380 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPK 7439

Query: 66   EHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
            +  + +  +  +D G Y+  A N  G A A   V VL+ P
Sbjct: 7440 KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP 7479



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/147 (23%), Positives = 67/147 (45%), Gaps = 6/147 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DG+ L    +   SSS  + +L +   ++ED G     + NS  +  + +  +    
Sbjct: 19123 WRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDR 19182

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP    + +   +++ ++W PPE         Y +E++E  S  W          +++
Sbjct: 19183 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19242

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH 603
             +      SE  Y+FR+C  + +G+S +
Sbjct: 19243 IVRLTTGSE--YQFRVCAENRYGKSSY 19267



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 60/268 (22%), Positives = 101/268 (37%), Gaps = 48/268 (17%)

Query: 1300  VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQD-------SRIFLV 1352
             V WY    +L +  + ++       +L V+     D G Y C    D       + +F+ 
Sbjct: 25295 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 25354

Query: 1353  SVEEPL-------------------LVKLVSELT-PL---TVHEGDDATFRCEVSP-PDA 1388
              V E                     L++   E T PL   T + G++  F   ++  P+ 
Sbjct: 25355 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 25414

Query: 1389  DVTWLRNGAVVTPGPQVEMAQNGSSR---ILTLRGCQLGDAGTVTLRA----GSTATSAR 1441
              VTW ++G  + PG   +     S +    LT+      D    T+ A    G  +  A+
Sbjct: 25415 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 25474

Query: 1442  L----HVRETEL----LFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHD 1493
             L    H   T+     +F R L +   +EGQ VC E+    +     ++W + GQPL   
Sbjct: 25475 LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGI-PPPTLKWEKDGQPLSLG 25533

Query: 1494  SRLSMAQDG-HIHRLFIHGVILADQGTY 1520
               + +  +G   + L I   +  D G Y
Sbjct: 25534 PNIEIIHEGLDYYALHIRDTLPEDTGYY 25561



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 19/187 (10%)

Query: 1725 LRSVSAREGDGATFECTVS-----EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
            L+SV   EG  ATFE  +S     EV      ++      PG ++    +G+  + + + 
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDGRAKLTIPAV 70

Query: 1780 LRAEDAGEVRFQA----GPAQSLA--LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS 1833
             +A ++G    +A    G A S A  L++ E  P    +   +  TV  G +  L+V V+
Sbjct: 71   TKA-NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL-QSMTVRQGSQVRLQVRVT 128

Query: 1834 RSGGHVC-WLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTH 1888
                 V  + R+GAE+     +++   G  +SL+I +  PED GTY   A    G+ ++ 
Sbjct: 129  GIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATST 188

Query: 1889 TRLLVEG 1895
              LLV+G
Sbjct: 189  AELLVQG 195



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 5/88 (5%)

Query: 1812  RHPPREKTVLVGRRAVLEVT-VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDV 1870
             R   ++ T  +G  A L    V R    + W R G EL    KY+M S G TH+L +   
Sbjct: 24231 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTE 24290

Query: 1871  RPEDQGTYCC----QAGQDSTHTRLLVE 1894
               ED+G Y C    + G+  T ++LL++
Sbjct: 24291 EQEDEGVYTCIATNEVGEVETSSKLLLQ 24318



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 25/93 (26%), Positives = 44/93 (47%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
            V+ G +  +       P P V W K G+++ AS+RL+   D     L +  ++  DAG+Y
Sbjct: 8093 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 8152

Query: 83   VCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
                 N  G A A+  V V+  P    +++ ++
Sbjct: 8153 TITLENKLGSATASINVKVIGLPGPCKDIKASD 8185



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 26/85 (30%), Positives = 40/85 (47%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             + V  G    +   V G P P + W K G+ L   +R+    D     L +  A+  D G
Sbjct: 11613 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 11672

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y+  A+N++G A  +A V VL+ P
Sbjct: 11673 KYIISAKNSSGHAQGSAIVNVLDRP 11697



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 33/101 (32%), Positives = 42/101 (41%), Gaps = 2/101 (1%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVW--EKGGQQLAASERLSFPADG 64
             D   P   L+    + V +G    L+  V G+P P V W  +K    L  S R+      
Sbjct: 11892 DLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA 11951

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                   LT A  +D G YV  A N AG   A A V VL+ P
Sbjct: 11952 DSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKP 11992



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 40/149 (26%), Positives = 63/149 (42%), Gaps = 8/149 (5%)

Query: 461   WSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             WS+ G+++    +   +S+     L +   TR+DAGE T +  N   T +  VK      
Sbjct: 14108 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDV 14167

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-IYRLERQEVGSEDW-IQCFSIEKAGAV 575
             PGPP   E+         LTW PP     +P   Y LE++E     W +    I+    V
Sbjct: 14168 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHV 14227

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                   +    +Y FR+  V+ +G+   V
Sbjct: 14228 ATK---LIQGNEYIFRVSAVNHYGKGEPV 14253



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 248   LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKV 306
             ++  P    ++EGK     C   G+P PE+ W   GR +   ++ R    + D    L +
Sbjct: 27026 IEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLII 27085

Query: 307   LYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             +  Q +D GLY  +  N  G   + V +H++
Sbjct: 27086 MDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 27116



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 83/382 (21%), Positives = 142/382 (37%), Gaps = 51/382 (13%)

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
            LV+    R D G  T  L N   T    +     + P  P   +     K++V LTW+PP
Sbjct: 7147 LVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPP 7206

Query: 542  EPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS--GH 598
            +    +P   Y +E++EV  + W +           VP D V  + +Y F++C  +  G 
Sbjct: 7207 DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP-DLVQGK-EYLFKVCARNKCGP 7264

Query: 599  GRSPHV---VFHGSAHLVP-----------TARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
            G   +V   V   +   VP           TA  +    D    DG   +    +    +
Sbjct: 7265 GEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPR 7324

Query: 645  GT--WFLNGEELKSNEPE--GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP 700
            G+  W   GE +   + E  G  E     YR++    Q                 G S P
Sbjct: 7325 GSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQ-----------------GASKP 7367

Query: 701  G--VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVE 757
                ++  A+  QE+P   L  +    LT     ++ L   ++    P  TW K    ++
Sbjct: 7368 SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILK 7427

Query: 758  ESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDPPVHIVDPRE 813
            + + + ++   +K  + + ++K  D+G +      V    +A   V V D P     P  
Sbjct: 7428 QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP----GPPA 7483

Query: 814  HVFVHAITSECVMLACEVDRED 835
               +  +T+E  +L     R+D
Sbjct: 7484 AFDITDVTNESCLLTWNPPRDD 7505



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 38/163 (23%), Positives = 62/163 (38%), Gaps = 16/163 (9%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
             +Q  PP  L  P  + + +G +  ++  V G+P P   W+KG  ++  S  L+     + 
Sbjct: 12590 EQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS 12648

Query: 67    HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS----------DPELQPAER 116
               L++      D+G Y   A N++G       V V++ P            D +      
Sbjct: 12649 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSW 12708

Query: 117   PLPSPGSGEGAPVFLTG----PRSQWVLRGAEVVLT-CRAGGL 154
              +P    G     ++       R  WV   A V  T CR G L
Sbjct: 12709 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKL 12751



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 117/570 (20%), Positives = 217/570 (38%), Gaps = 77/570 (13%)

Query: 345   RPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLK 403
             + ++DV  +    A L C++    +P   W+R  + L+  RKY+   +G    L +   +
Sbjct: 24232 KEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEE 24291

Query: 404   ADDDGIYLCEMRGRVRTVANVTVKGPILKRLPR---------KLDVLEGENAVLLVETLE 454
              +D+G+Y C     V  V   T    +L+  P+         K     G    L V  + 
Sbjct: 24292 QEDEGVYTCIATNEVGEVE--TSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIG 24349

Query: 455   AGVEGRWSRDGEEL----PVICQSSSGHMHALVLPGVTRED-AGEVTFSLGNSRTTTL-- 507
               V       G++L      I   ++ H   LV+  V R+  AG+    L N   T    
Sbjct: 24350 RPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAI 24409

Query: 508   --LRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE-----TPFIYRLERQEVGS 560
               + ++     P GP ++  + K   N+ +++WKP  PA +     T ++      + G+
Sbjct: 24410 LDVEIQDKPDKPTGPIVIEALLK---NSAVISWKP--PADDGGSWITNYVVEKCEAKEGA 24464

Query: 561   EDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP-----HVVFHGSAHLVPT 615
             E W    S        +    +     Y FR+   +  G S       VV   S    P 
Sbjct: 24465 E-WQLVSSAISVTTCRIVN--LTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG 24521

Query: 616   ARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT----WFLNGEELKSNE----PEGQVEPGA 667
             A    G   +     +  V +        G     ++L   E K N+       ++    
Sbjct: 24522 A---PGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETV 24578

Query: 668   LRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSP---QDRV 724
                +   +GL++      VK ++ G    +S    + S  +T  +S V I +P   ++  
Sbjct: 24579 FSVKNLIEGLEYEF---RVKCENLGGESEWS----EISEPIT-PKSDVPIQAPHFKEELR 24630

Query: 725   SLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELL--VVKMDGRKHRLILPEAKVQ 781
             +L         L C+++    P   WY+ G+++    L   + +  G  H+LI+      
Sbjct: 24631 NLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDD 24690

Query: 782   DSGEFECRTEG----VSAFFGVTVQDPP-VHIVDPREHV-FVHAITSECVMLACEVDRED 835
             D+  ++ R       VS    + V+ P  +H+    E +  VHA+  E V +      + 
Sbjct: 24691 DATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKP 24750

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLV 865
              PV  ++ GQ+       +++N G ++ +V
Sbjct: 24751 DPVITWQKGQD-------LIDNNGHYQVIV 24773



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 60/287 (20%), Positives = 101/287 (35%), Gaps = 49/287 (17%)

Query: 1461  EEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
             EEG  V    +      +  V W  G + L +  +  +  +  +  L++  +   D GTY
Sbjct: 25275 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 25334

Query: 1521  GCESHHD------------------------RTLARLSVRPRQLRVLRPLEDVTISEGGS 1556
              C+  +D                        RT+ ++  R   +R+L    + T+     
Sbjct: 25335 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 25394

Query: 1557  ATFQLELSQEGVT--------GEWARGGVQLYPG---PKCHIHSDGHRHRLVLNGLGLAD 1605
               +  E  + GVT          W + G ++ PG    K    SD   ++L +N +   D
Sbjct: 25395 TAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDD 25454

Query: 1606  SGCVSFTA------DSLRCAARLIVREVPVTIVRGP------HDLEVTEGDTATFECELS 1653
                 +  A      DS +    + +   P      P       + E  EG +  FE  +S
Sbjct: 25455 DAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVS 25514

Query: 1654  Q-ALADVTWEKDGNALTPSPRLRLQALG-TRRLLQLRRCGPSDAGTY 1698
                   + WEKDG  L+  P + +   G     L +R   P D G Y
Sbjct: 25515 GIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 25561



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 6/107 (5%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             +F   + V +G    L+  V G+P P + W +G +++  S R        +  L++  A+
Sbjct: 17325 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAI 17384

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
               D G Y+ RA N AG       V VL+ P       P E P+   G
Sbjct: 17385 RIDGGQYILRASNVAGSKSFPVNVKVLDRPG------PPEGPVQVTG 17425



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 17/180 (9%)

Query: 1284 GGDLELVVHLSG-PGGPVRWYKDGERLASQGR--VQLEQAGARQVLRVQGARSGDAGEYL 1340
            G       H+SG P   V W++DG+ +++     VQ+  +  R  L +      ++G Y 
Sbjct: 20   GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79

Query: 1341 CDAPQDSRIFLVSVEEPLLVK-------LVSELTPLTVHEGDDATFRCEVSP-PDADVTW 1392
              A   S     + E  LLVK        V  L  +TV +G     +  V+  P   V +
Sbjct: 80   LKATNGSGQATSTAE--LLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKF 137

Query: 1393 LRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETE 1448
             R+GA +      +++Q G    L +      D+GT ++ A    G   ++A L V+  E
Sbjct: 138  YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEE 197



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 29/110 (26%), Positives = 43/110 (39%), Gaps = 2/110 (1%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P   R   P+ V  G  A+  C +   P     W K G+++  S++ S  +      L +
Sbjct: 4529 PVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEI 4588

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP--ELQPAERPLP 119
                  D G Y C+A N  G     A +TV  P       +L P  +P P
Sbjct: 4589 LRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPERKPEP 4638



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 23/75 (30%), Positives = 35/75 (46%)

Query: 31    LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAA 90
             LK  + G+P P V W+KG   LA   R+S  +      L++     +DAG Y    +N A
Sbjct: 13697 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 13756

Query: 91    GEAYAAAAVTVLEPP 105
             G      ++ V+  P
Sbjct: 13757 GTKEGTISIKVVGKP 13771



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 6/104 (5%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   V + +G    L+  V G PPP + W K G++L  + +L          L+   +
Sbjct: 15160 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDS 15219

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL 118
                D+G Y   A N  G A     V VL+ P       P E PL
Sbjct: 15220 TRRDSGAYTLTATNPGGFAKHIFNVKVLDRPG------PPEGPL 15257



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 1/89 (1%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G + ++     G PPP V W K  + L +  R S     +   L +      D G Y+ 
Sbjct: 20980 AGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYIL 21039

Query: 85    RARNAAGEAYAA-AAVTVLEPPASDPELQ 112
                N  GE  ++  +V VL+ PA+  +LQ
Sbjct: 21040 TIENGVGEPKSSTVSVKVLDTPAACQKLQ 21068



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 50/213 (23%), Positives = 75/213 (35%), Gaps = 40/213 (18%)

Query: 1721  VLSELRSVSAREGDGATFECTVSEVE--TTGRWELGGRPLRPGARVRIRQEGKKHILVLS 1778
             V  ++      EG    + C +   +  T   W  G R L    +  I  E    IL + 
Sbjct: 25265 VSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVK 25324

Query: 1779  ELRAEDAGEVRFQA----GPAQSLALLEVEAL--------------------PLQMCRHP 1814
             ++   D G  R +     G   S A L V+ +                     +++   P
Sbjct: 25325 DITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERP 25384

Query: 1815  PR------EKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGD---KYEMRSHGPTHS 1864
             P        KT  VG      VT++     HV W + G ++ PGD   KY   S    + 
Sbjct: 25385 PEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQ 25444

Query: 1865  LVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
             L I+ V  +D   Y   A    G+DS   +L V
Sbjct: 25445 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/91 (30%), Positives = 37/91 (40%), Gaps = 1/91 (1%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE-HGLL 70
             P F R         G     +  V G PPP + WEK GQ L+    +    +G + + L 
Sbjct: 25490 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25549

Query: 71    LTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
             +   LP D G Y   A N AG     A + V
Sbjct: 25550 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 25580



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 32/124 (25%), Positives = 53/124 (42%), Gaps = 3/124 (2%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             L +     ED G  + ++ N   +  + VK +    PGPP   E+ +  K++  LTWK P
Sbjct: 10969 LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEP 11028

Query: 542   -EPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
              +        Y +ER++V S  W    +  K  +       +     Y FR+   + +GR
Sbjct: 11029 LDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH--LNEGNQYLFRVAAENQYGR 11086

Query: 601   SPHV 604
              P V
Sbjct: 11087 GPFV 11090



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 8/90 (8%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
            PPGPP   E+    K+++ L WKPP     +P   Y +E QE G+ DW +   + +   +
Sbjct: 9399 PPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKR---VNEPDKL 9455

Query: 576  EVPGDCVPSE----GDYRFRICTVSGHGRS 601
                +CV         YRFR+  V+  G S
Sbjct: 9456 ITTCECVVPNLKELRKYRFRVKAVNEAGES 9485



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 23/83 (27%), Positives = 32/83 (38%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G       ++ G P P   W   G ++   E  +   D     L +   L  D G Y
Sbjct: 11217 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEY 11276

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  NAAG    A  +TVL+ P
Sbjct: 11277 QITVSNAAGSKTVAVHLTVLDVP 11299



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/465 (21%), Positives = 172/465 (36%), Gaps = 60/465 (12%)

Query: 1021  RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
             +W  DG E++  E   +E D     L +      D GE+     + +   TV V      
Sbjct: 11238 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 11297

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAP--AGSQVRWYKDGLEVEASDALQLGAEGPTRT- 1137
             +  P    +++    P  + +  +      GS V  Y    +    D   + + G ++T 
Sbjct: 11298 VPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTK 11357

Query: 1138  LTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALE-----TTPSPLCVAPGEPVV 1192
             L +PH Q     EYV   R E    N I   PP+           + PSP    PG+PVV
Sbjct: 11358 LKIPHLQK--GCEYVFRVRAE----NKIGVGPPLDSTPTVAKHKFSPPSP----PGKPVV 11407

Query: 1193  LSCELSRAGAPVVW----SHNGRPVQ---------EGEGLELHAEGPRRVLCIQAAGPAH 1239
                +++   A V W    S  G P+           G+ + ++ + P   L  +  G   
Sbjct: 11408 T--DITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVN-KTPIADLKFRVTGLYE 11464

Query: 1240  AGLYTCQ------SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
                Y  +      +G +  +PS S  ++   P      P   + + +S    DL     L
Sbjct: 11465 GNTYEFRVFAENLAGLSKPSPS-SDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPL 11523

Query: 1294  SGPGGPVRWY-----KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----- 1343
             S  G P+  Y     K G   A   R+  ++   +   RV G   G+   +   A     
Sbjct: 11524 SDGGSPILGYVVECQKPGT--AQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11581

Query: 1344  ---PQD--SRIFLVSVEEPLLVKL-VSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
                P++    +    +  P  V+L V+    +TV  G        V   P+ D+TW + G
Sbjct: 11582 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11641

Query: 1397  AVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSAR 1441
              V+    +V++ Q+     L ++     D G   + A +++  A+
Sbjct: 11642 KVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQ 11686



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 72/378 (19%), Positives = 127/378 (33%), Gaps = 62/378 (16%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R + V +G    +   + G P P V W K    L    R +     +   L++      D
Sbjct: 14479 RTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINL--KNRANIENTESFTLLIIPECNRYD 14536

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQ 137
              G +V    N AG+      V VL+ P     L+P +    S       P+   G R + 
Sbjct: 14537 TGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITN 14596

Query: 138   WVLRGAEV-------------------------------VLTCRAGGLPEPTLYWEK--- 163
             +++   E                                V+     G+ EPT   E    
Sbjct: 14597 YIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 14656

Query: 164   -------DGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYV-------- 208
                    D + + ++  S+     P    DG G+ +   ++ A+   S  +         
Sbjct: 14657 SEAPSPPDSLNIMDITKSTVSLAWPKPKHDG-GSKITGYVIEAQRKGSDQWTHITTVKGL 14715

Query: 209   -CHARN-AHGHAQAGALLQVHQPPESPPADP------DEAPAPVVEPLKCAPKTFWVNEG 260
              C  RN   G      ++ V+    S P +       ++   P ++      K      G
Sbjct: 14716 ECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 14775

Query: 261   KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              + K    V+G+P+P + W  +G  +L   +R+ +       +L +  C   D G Y   
Sbjct: 14776 DNIKVEIPVLGRPKPTVTWK-KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 14834

Query: 321   ARNSAGQTLSAVQLHVKE 338
             ARN  G+    + + V +
Sbjct: 14835 ARNIVGEVGDVITIQVHD 14852



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 24/83 (28%), Positives = 39/83 (46%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + +G + +++  V+G P P + W K G+ L  + R++         L +      D G Y
Sbjct: 18018 IQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKY 18077

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A N+AG A    +V VLE P
Sbjct: 18078 TVTATNSAGTATENLSVIVLEKP 18100



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 22/92 (23%), Positives = 40/92 (43%)

Query: 10    SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
             S P  +   +   V S + A+      GEP P  +W K G+ +    +     D     L
Sbjct: 26545 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFL 26604

Query: 70    LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +     +D+G+Y C  +N+AG   ++  +T+
Sbjct: 26605 EIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 52/216 (24%), Positives = 87/216 (40%), Gaps = 29/216 (13%)

Query: 727 TFTTSERVVLTCELSRVDFPA----------TWYKDGQKVEESELLVVKM---DGRKHRL 773
           TFT   + V+  E S   F A          +W++DGQ +  S L  V++   DGR  +L
Sbjct: 7   TFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA-KL 65

Query: 774 ILPEAKVQDSGEFECRTEGVS------AFFGVTVQDPPVHIVDPREHVFVHAITSECVML 827
            +P     +SG +  +    S      A   V  +  P + V   + + V   +   V L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ--VRL 123

Query: 828 ACEVDREDAPV-RWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
              V     PV ++Y+DG E++ S    +  EG    L++    P D G +   A +   
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183

Query: 887 YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL 922
             T T        +   G+  V A + + +V T ++
Sbjct: 184 RATSTAE------LLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 5/122 (4%)

Query: 219   QAGALLQVHQPPESPPADPDEAPAPVVEP---LKCAPKTFW-VNEGKHAKFRCYVMGKPE 274
             +A A   V+  P S P+DP    A  V P   L  A K+   V  G +      V GKP 
Sbjct: 12960 RAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPM 13019

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P + W  +G  L P     M   R+    L++     KD G Y   A NS+G   + ++L
Sbjct: 13020 PTVSWKKDGTLLKPAEGIKMAMQRN-LCTLELFSVNRKDSGDYTITAENSSGSKSATIKL 13078

Query: 335   HV 336
              V
Sbjct: 13079 KV 13080



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 23/87 (26%), Positives = 34/87 (39%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + + V +G   EL   + G PPP   W   G +L  SER++         L +      D
Sbjct: 23441 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRD 23500

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPP 105
              G Y    +N  G       V +L+ P
Sbjct: 23501 TGEYTLELKNVTGTTSETIKVIILDKP 23527



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 48/225 (21%), Positives = 86/225 (38%), Gaps = 25/225 (11%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G    L+C+  G P P + W + G    E+  S  + +         G +  L ++    
Sbjct: 24242 GEAAQLSCQIVGRPLPDIKWYRFGK---ELIQSRKYKMS------SDGRTHTLTVMTEEQ 24292

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGK 261
              D GVY C A N  G  +  + L +   P+  P            PLK   + ++   G 
Sbjct: 24293 EDEGVYTCIATNEVGEVETSSKLLLQATPQFHPG----------YPLK---EKYYGAVGS 24339

Query: 262   HAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR-GLYVCA 320
               +     +G+P P + W + G+ LL +   +   + +    L +   Q K   G Y   
Sbjct: 24340 TLRLHVMYIGRPVPAMTW-FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ 24398

Query: 321   ARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
               N  G   + + + +++   + T P+  +E      AV+  K P
Sbjct: 24399 LSNVFGTVDAILDVEIQDKPDKPTGPIV-IEALLKNSAVISWKPP 24442



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 2/99 (2%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             +G +G PP     P  + +  G    + C   GEP P V W  GG+++ + E+  F  + 
Sbjct: 27017 AGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIEN 27076

Query: 65    AEH--GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +    L++      D G+Y     N  G   A   + +
Sbjct: 27077 TDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27115



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 25/83 (30%), Positives = 35/83 (42%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + SG    +K +V G P P V W K G ++     +          L +  A     GVY
Sbjct: 21665 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 21724

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+NA+G A A   V V + P
Sbjct: 21725 TVEAKNASGSAKAEIKVKVQDTP 21747



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 119/577 (20%), Positives = 207/577 (35%), Gaps = 118/577 (20%)

Query: 1111 QVRWYKDGLEVEASDALQLG-AEGPTRTLTLPHAQPEDAGEYVC---ETRHEAITFNVIL 1166
            ++ WYKDG  ++  +  Q+   +    +L +P   PED G Y       +  AI    + 
Sbjct: 1275 KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY 1334

Query: 1167 AEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGP 1226
             EP     A      P  +   EPV      SR  +    S +  P++           P
Sbjct: 1335 VEPAAPLGA------PTYIPTLEPV------SRIRSLSPRSVSRSPIRMSPA----RMSP 1378

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGD 1286
             R+       PA         G        S   ++ +P V V+ P + +     T   D
Sbjct: 1379 ARM------SPARMSPARMSPGRRLEETDESQLERLYKP-VFVLKPVSFKCLEGQTARFD 1431

Query: 1287 LELVVHLSGPGGPVRWYKDGERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAP 1344
            L++V     P     W+ DG+++ +    +V +++ G + ++ V    S D+GE+   A 
Sbjct: 1432 LKVV---GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPS-DSGEWTVVAQ 1487

Query: 1345 QDSRIFLVSV-------EEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
              +    +SV       E  +    V +L  + + EG     +   +  P+ D+ WL+N 
Sbjct: 1488 NRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS 1547

Query: 1397 AVVTPG--PQVEMAQNGSSRILTLRGCQLGDA----GTVTLRAGSTATSARLHVR----- 1445
             ++ P   P++ +        L +      D+     T   +AG   T  +++V      
Sbjct: 1548 DIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAE 1607

Query: 1446 ---ETELLFLR---RLQDVRAEE--------GQDVCLE--------------------VE 1471
               E +L+  R   R +++ A E        GQ+   E                    + 
Sbjct: 1608 PEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1667

Query: 1472 TGRVGAAG-------------AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQG 1518
              R G A               V W+  G+PL   +RL M  +     L        D G
Sbjct: 1668 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSG 1727

Query: 1519 TYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE----LSQEG-VT 1569
               C + +    D T A L V+  +  V    E+  + EG     ++E    ++ EG +T
Sbjct: 1728 IITCRATNKYGTDHTSATLIVKDEKSLV----EESQLPEGRKGLQRIEELERMAHEGALT 1783

Query: 1570 G------EWARGGVQLYPGPKCHIHSDGHRHRLVLNG 1600
            G      E  +  + LYP P   +  +  R R  + G
Sbjct: 1784 GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTG 1820



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 40/139 (28%), Positives = 50/139 (35%), Gaps = 23/139 (16%)

Query: 205  GVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV----EPLKCAPKTFWVNEG 260
            G YVC A N  G     A L V +             APV+    EPL+ A        G
Sbjct: 4502 GEYVCEALNDSGKTATSAKLTVVK-----------RAAPVIKRKIEPLEVAL-------G 4543

Query: 261  KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              AKF C +   P    +W   GR +  +  +   R       L++L  Q  D G Y C 
Sbjct: 4544 HLAKFTCEIQSAPNVRFQWFKAGREIY-ESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 4602

Query: 321  ARNSAGQTLSAVQLHVKEP 339
            A N  G       L V  P
Sbjct: 4603 ASNEYGSVSCTATLTVTVP 4621



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 79/341 (23%), Positives = 128/341 (37%), Gaps = 51/341 (14%)

Query: 105   PASDPELQPAERPLPSPG----------SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGL 154
             P+SDP    A RP+  PG          S E A +  T P S         V+ C+  G 
Sbjct: 11485 PSSDPI--KACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG- 11541

Query: 155   PEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
                T  W +  +  DE+     F + PG  E   G     RI AA +   G         
Sbjct: 11542 ---TAQWNR--INKDELIRQCAFRV-PGLIE---GNEYRFRIKAANIVGEG-------EP 11585

Query: 215   HGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                A++     +  PPE             VE          V  G+  +    V G+PE
Sbjct: 11586 RELAESVIAKDILHPPE-------------VELDVTCRDVITVRVGQTIRILARVKGRPE 11632

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P+I W  EG+ L+ ++R  + +D      L++      D G Y+ +A+NS+G    +  +
Sbjct: 11633 PDITWTKEGKVLVREKRVDLIQDLP-RVELQIKEAVRADHGKYIISAKNSSGHAQGSAIV 11691

Query: 335   HVKEPRLRFTRPLQDVE----GREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
             +V    L    P Q+++     +E+     E  + N       F  + R    + +  + 
Sbjct: 11692 NV----LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVA 11747

Query: 391   EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
                 +RLI   L A+++  +      +V     +  K PIL
Sbjct: 11748 SDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPIL 11788



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 25/100 (25%), Positives = 41/100 (41%), Gaps = 1/100 (1%)

Query: 239   EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDR 298
             EA   ++ P    P+   +  GK  +   +V GKP P  +W  +G   +     L     
Sbjct: 12587 EAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKA 12645

Query: 299   DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
             D   +L +     KD G Y   A NS+G     +++ V +
Sbjct: 12646 DSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMD 12685



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 1/85 (1%)

Query: 458   EGRWSRD-GEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             E +W+RD GE L      S+     L++  V R D+G+   ++ NS  +    V      
Sbjct: 15586 EVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLD 15645

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPP 541
              PGPP   ++ +  K +V LTW PP
Sbjct: 15646 TPGPPQDLKVKEVTKTSVTLTWDPP 15670



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 34/119 (28%), Positives = 47/119 (39%), Gaps = 11/119 (9%)

Query: 231   ESPPADPDEAPAPVVEP-------LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             E   +DP     PV+         LK    T+ +  G+  K    V+G+P P I W  +G
Sbjct: 17985 EKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDG 18044

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG---QTLSAVQLHVKEP 339
              P L    R+   +     VL +      D G Y   A NSAG   + LS + L    P
Sbjct: 18045 EP-LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGP 18102



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 23/91 (25%), Positives = 42/91 (46%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             L +   V+  +G   +L+  + G+P P + W K  ++L  +  +          +L+  A
Sbjct: 20571 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDA 20630

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                ++G Y  + RNA G A A   V +L+ P
Sbjct: 20631 DRLNSGCYELKLRNAMGSASATIRVQILDKP 20661



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 21/182 (11%)

Query: 1178 TTPSPLCVAPGEPVVL------SCELSRAGAPVV---WSHNGRPVQEGE--GLELHAEGP 1226
            TT +P    P + VV+      + E   +G PV    W  +G+ +      G+++     
Sbjct: 2    TTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDG 61

Query: 1227 RRVLCIQAAGPAHAGLYTCQ----SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRST 1282
            R  L I A   A++G Y+ +    SG A     L    + A PP  V   ++   R    
Sbjct: 62   RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA-PPNFVQRLQSMTVR---- 116

Query: 1283 PGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
             G  + L V ++G P   V++Y+DG  + S    Q+ Q G    L +  A   D+G Y  
Sbjct: 117  QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176

Query: 1342 DA 1343
            +A
Sbjct: 177  NA 178



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 7/101 (6%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQL-AASERLSFPADGAEHGLLLTAALPTDAGV 81
             V +G    L+  + G+P P VVW K G++L   + R+   +   +  L++   + TD G 
Sbjct: 18414 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 18473

Query: 82    YVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             Y+ +  N  G       V VL+ P       P E PL   G
Sbjct: 18474 YILKLSNVGGTKSIPITVKVLDRPG------PPEGPLKVTG 18508



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 68/300 (22%), Positives = 118/300 (39%), Gaps = 39/300 (13%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAG 573
             SP  PP   +     + T+ L W PP     +  + Y +E+++ G+E W++C F+     
Sbjct: 21548 SPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSEC 21606

Query: 574   AVEVPGDCVPSEGD-YRFRIC------TVSGHGRSPHVVFHGSAHLVPTARLVAGLED-V 625
                V G    S GD Y FRI       T+S   +S  ++     ++ P         D +
Sbjct: 21607 QYTVTG---LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGL 21663

Query: 626   QVYDGEDAVFSLDLSTIIQG------TWFLNGEEL-KSNEPEGQVEPGALRYRIEQKGLQ 678
              +  GE    SL +  ++QG      TWF +G E+ K    E     G+    +      
Sbjct: 21664 IIKSGE----SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRD 21719

Query: 679   HRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTC 738
             HR +        SG+         +    + +Q++P  ++ P   +  T  T E++ L  
Sbjct: 21720 HRGVYTVEAKNASGS--------AKAEIKVKVQDTPGKVVGP---IRFTNITGEKMTLWW 21768

Query: 739   ELSRVD--FPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
             +    D   P T Y   +K E S L    ++ +         K+ +  E++ R   V+ F
Sbjct: 21769 DAPLNDGCAPITHYII-EKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKF 21827



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 38/150 (25%), Positives = 57/150 (38%), Gaps = 30/150 (20%)

Query: 80   GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWV 139
            G YVC A N +G+   +A +TV++  A  P ++    PL                    V
Sbjct: 4502 GEYVCEALNDSGKTATSAKLTVVKRAA--PVIKRKIEPLE-------------------V 4540

Query: 140  LRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAA 199
              G     TC     P     W K G    E+++S   +++  +         +L IL  
Sbjct: 4541 ALGHLAKFTCEIQSAPNVRFQWFKAGR---EIYESDKCSIRSSKYIS------SLEILRT 4591

Query: 200  RLPDSGVYVCHARNAHGHAQAGALLQVHQP 229
            ++ D G Y C A N +G     A L V  P
Sbjct: 4592 QVVDCGEYTCKASNEYGSVSCTATLTVTVP 4621



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 38/252 (15%)

Query: 373  WFREDQRLLPCRKY--EQIEEGTVRRLIIHRLKADDDG-------IYLCEMRGRVRTVAN 423
            W R  ++++  R+Y  ++I EG   +L +  + A  +G       + + E +       +
Sbjct: 8743 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELD 8802

Query: 424  VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGEELPV--ICQSS 475
            V+VKG I         ++ G+        + A V GR      W+++  EL    +   +
Sbjct: 8803 VSVKGGI--------QIMAGKTL-----RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDN 8849

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
             G    L++    R+D G    +  NS  +     +      PGP +  +    ++   L
Sbjct: 8850 VGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCL 8909

Query: 536  LTWKPPEP---APETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
            L W  PE    +  T FI  +ER++     W Q    E++   ++ G  +    +Y+FR+
Sbjct: 8910 LNWSDPEDDGGSEITGFI--IERKDAKMHTWRQPIETERS-KCDITG--LLEGQEYKFRV 8964

Query: 593  CTVSGHGRSPHV 604
               +  G  P V
Sbjct: 8965 IAKNKFGCGPPV 8976



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 34/112 (30%), Positives = 46/112 (41%), Gaps = 11/112 (9%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    L   V G+P P V W+K G  L  +E +          L L +    D+G Y
Sbjct: 13002 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDY 13061

Query: 83    VCRARNAAGEAYAAAAVTVLE---PPA--------SDPELQPAERPLPSPGS 123
                A N++G   A   + VL+   PPA        SD  +   E PL   GS
Sbjct: 13062 TITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGS 13113



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 22/86 (25%), Positives = 42/86 (48%), Gaps = 1/86 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP   +++   +++V L+W  P     +P I Y +E +   S++W++C   +     
Sbjct: 13283 PPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKT 13342

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
                   +  +  Y+FR+  V+  G S
Sbjct: 13343 RFEVTGLMEDTQYQFRVYAVNKIGYS 13368



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 108/551 (19%), Positives = 196/551 (35%), Gaps = 81/551 (14%)

Query: 418   VRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ--- 473
             V  +A   V  P  K L     VL GE+  + V  +        W +D   L    +   
Sbjct: 15832 VPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNA 15891

Query: 474   SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPI-LAEMFKGHKN 532
              S+ +   L +    RED G     L NS    +  +  +    PGPP    +M +   +
Sbjct: 15892 ESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTAD 15951

Query: 533   TVLLTWKPPE-PAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
             ++ L+W PP+     +   Y +E+++  +  W Q  S   A    +    + +  +Y+FR
Sbjct: 15952 SITLSWGPPKYDGGSSINNYIVEKRDTSTTTW-QIVSATVA-RTTIKACRLKTGCEYQFR 16009

Query: 592   ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
             I   + +G+S ++    +    P               G      + LS+        + 
Sbjct: 16010 IAAENRYGKSTYLNSEPTVAQYPFK-----------VPGPPGTPVVTLSS-------RDS 16051

Query: 652   EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
              E++ NEP        + Y +E+K  +   IL    ++       F   G+++      +
Sbjct: 16052 MEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFR 16109

Query: 712   ESPVHI--LSPQDRVSLTFTT---------SERVVLTCELSRVDFPATWYKDGQK----- 755
              S  +I  +    +VS  +            E +++T     + +    Y  G K     
Sbjct: 16110 VSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYI 16169

Query: 756   VEESELLVVKMDGR---------------------KHRLILPEAKVQDSGEFECRTEGVS 794
             VE+ EL     +GR                      HR          +G F   +E   
Sbjct: 16170 VEKKEL----PEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTG 16225

Query: 795   AFFGVTVQDPPVHIVDP--REHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESD 851
             A       DPP   +DP  ++ + VHA   E   +  ++  +  P ++W K  QE+  + 
Sbjct: 16226 AITARDEVDPPRISMDPKYKDTIVVHA--GESFKVDADIYGKPIPTIQWIKGDQELSNTA 16283

Query: 852   FVVLENEGPHRRLVLPATQPSDGGEF----QCVAGDECAYFTVTITDVSSWIVYPSGKVY 907
              + +++      L +      D G +    + VAG+      V + D       P G V 
Sbjct: 16284 RLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG---PPEGPVV 16340

Query: 908   VAAVRLERVVL 918
             ++ V  E+  L
Sbjct: 16341 ISGVTAEKCTL 16351



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 94/441 (21%), Positives = 167/441 (37%), Gaps = 67/441 (15%)

Query: 461   WSRDGEELP--VICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP 518
             WS+ G +L    I  ++  +   L++  V R DAG+ T    N        V    +  P
Sbjct: 23175 WSKQGIDLASRAIIDTTESYS-LLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 23233

Query: 519   GPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEV 577
             GP    ++ +  +++V +TW+ P      P   Y +E++E     +    +        +
Sbjct: 23234 GPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRI 23293

Query: 578   PGDCVPSEGD-YRFRICTVSGHG-----RSPHVVFHGSAHLVP--------TARLVAGLE 623
              G     EG  Y FR+   + +G      +   V      LVP        T   V    
Sbjct: 23294 SGLV---EGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAW 23350

Query: 624   DVQVYDGEDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQ--KGLQH 679
             +  +YDG   +    L     GT  W               ++P  L + +    +G Q+
Sbjct: 23351 EKPLYDGGSRLTGYVLEACKAGTERWM----------KVVTLKPTVLEHTVTSLNEGEQY 23400

Query: 680   RLILHAVKHQDSGALVGFSCPGVQDSAALTIQES---PVHILSPQDRVSLTFTTSERVVL 736
                + A   +      G S P  +   A+T+Q+    P   LS   + ++       V L
Sbjct: 23401 LFRIRAQNEK------GVSEPR-ETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 23453

Query: 737   TCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA 795
                ++    PA +W+  G K+ ESE + V+   +  +L + E  ++D+GE+    + V+ 
Sbjct: 23454 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVT- 23512

Query: 796   FFGVTVQDPPVHIVD----PREHVFVHAITSECVMLACEVDRED--APVRWYKDGQEVEE 849
               G T +   V I+D    P   + +  I +  + ++ E    D  AP+  Y        
Sbjct: 23513 --GTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGY-------- 23562

Query: 850   SDFVVLENEGPHRRLVLPATQ 870
                 V+E    HR   LP ++
Sbjct: 23563 ----VVEQRDAHRPGWLPVSE 23579



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/219 (24%), Positives = 82/219 (37%), Gaps = 32/219 (14%)

Query: 127   APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
             AP F    R+  V   +   L C+  G P+P + W + G  +  + D   +     R ++
Sbjct: 24622 APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEI--IADGLKY-----RIQE 24674

Query: 187   GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
               G    L I +    D+ VY   A N  G     A L+V            E PA +  
Sbjct: 24675 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------------EVPAKI-- 24720

Query: 247   PLKCAPKTFWVNEGKHA------KFRCYVMGKPEPEIEWHWEGRPLLPDRRRL-MYRDRD 299
                  PKT       HA        +    GKP+P I W  +G+ L+ +     +   R 
Sbjct: 24721 ---HLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRS 24776

Query: 300   GGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
                ++     + KD G YV  A+N  G     V+L V +
Sbjct: 24777 FTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 24815



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 58/260 (22%), Positives = 101/260 (38%), Gaps = 55/260 (21%)

Query: 259   EGKHAKFRCYVMGKPEP-EIEWHWEGRPLL-PDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             EG H K+ C +    +  ++ W++  R L   ++  + Y D  G  +L V      D G 
Sbjct: 25276 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED--GVAILYVKDITKLDDGT 25333

Query: 317   YVCAARNSAGQTLSAVQLHVKEPRLRF----TRPLQDVEGREHGIAVLECKVPNSRIP-- 370
             Y C   N  G+  S  +L VK  R  +     R ++ ++ R   + +LE + P   +P  
Sbjct: 25334 YRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLE-RPPEFTLPLY 25392

Query: 371   -----------------------TAWFREDQRLLP---CRKYEQIEEGTVRRLIIHRLKA 404
                                      W++  Q++ P    +KY    +  + +L I+ +  
Sbjct: 25393 NKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTT 25452

Query: 405   DDDGIYLCEMR---GRVRTVANVTVK----------GPILKRLPRKLDVLEGENAVLLVE 451
             DDD  Y    R   G     A +TV            P+ KRL    +  EG++  +  E
Sbjct: 25453 DDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQS--VCFE 25510

Query: 452   TLEAGVEG---RWSRDGEEL 468
                +G+     +W +DG+ L
Sbjct: 25511 IRVSGIPPPTLKWEKDGQPL 25530



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 45/169 (26%), Positives = 63/169 (37%), Gaps = 38/169 (22%)

Query: 85   RARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAE 144
            RA NAAG         + EP  + P  +  + P+ +P       V L    S  V RG E
Sbjct: 8350 RAENAAG---------ISEPSRATPPTKAVD-PIDAP------KVILR--TSLEVKRGDE 8391

Query: 145  VVLTCRAGGLPEPTLYWEKDGMAL-----------------DEVWDSSHFAL---QPGRA 184
            + L     G P PT+ W KD   +                  EV +   F L   Q    
Sbjct: 8392 IALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSI 8451

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
            ++       LR+  +  PD G+Y+    N HG A+A   + V   P  P
Sbjct: 8452 DNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPP 8500



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 6/145 (4%)

Query: 914   ERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC-- 970
             E   L+C++  RP  +++W + G+E+++S    +  +     L +   + ED G Y C  
Sbjct: 24243 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24302

Query: 971   --EIDD-ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGL 1027
               E+ + E++S  +    P     YP  E    AV     + +  + R    + W+    
Sbjct: 24303 TNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK 24362

Query: 1028  EVEESEALVLERDGPRCRLVLPAAQ 1052
              ++ SE + +E       LV+   Q
Sbjct: 24363 LLQNSENITIENTEHYTHLVMKNVQ 24387



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 44/168 (26%), Positives = 71/168 (42%), Gaps = 14/168 (8%)

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTG-EWARGG----VQLYPGPKCHIHSDGHRHRLVL 1598
            +PL+ V + EG +ATF+  +S   V    W R G        PG +    SDG R +L +
Sbjct: 10   QPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDG-RAKLTI 67

Query: 1599 NGLGLADSGCVSFTADS----LRCAARLIVR--EVPVTIVRGPHDLEVTEGDTATFECEL 1652
              +  A+SG  S  A +        A L+V+    P   V+    + V +G     +  +
Sbjct: 68   PAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRV 127

Query: 1653 SQALADVT-WEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYS 1699
            +     V  + +DG  +  S   ++   G    L +    P D+GTYS
Sbjct: 128  TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 61/249 (24%), Positives = 93/249 (37%), Gaps = 58/249 (23%)

Query: 1614 DSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSP 1672
            ++ R  A + +   P T+V G  ++ V EG++ T EC +S      VTW ++   +  S 
Sbjct: 882  ETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI 941

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTAR-----AGPVRLTVRERTVAV-- 1721
              ++        L +R     D+G ++C+     GT       A  V     + T AV  
Sbjct: 942  DFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001

Query: 1722 ---LSELRSVSAR----------------------------------EGDGATFECTV-S 1743
                 E R V +R                                  EG    F C V  
Sbjct: 1002 KFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGG 1061

Query: 1744 EVETTGRWELGGRPLRPGARVRI---RQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
              +    W+  G PL  G R ++   +Q G+   LV+S   A+DAGE    VR + G   
Sbjct: 1062 NPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECK-LVISMTFADDAGEYTIVVRNKHGETS 1120

Query: 1797 SLALLEVEA 1805
            + A L  EA
Sbjct: 1121 ASASLLEEA 1129



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 35/144 (24%), Positives = 63/144 (43%), Gaps = 7/144 (4%)

Query: 232   SPPADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
             S P  P ++  P+  P  K   +   V    +A   C V G P+P ++W+ +G+ ++ D 
Sbjct: 24609 SEPITP-KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 24667

Query: 291   RRLMYRDRDGGF-VLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP-RLRFTRPLQ 348
              +   ++  GG+  L +      D  +Y   A N  G       L V+ P ++   + L+
Sbjct: 24668 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLE 24727

Query: 349   DVEGREHGI--AVLECKVPNSRIP 370
              + G  H +   V+  K+P S  P
Sbjct: 24728 GM-GAVHALRGEVVSIKIPFSGKP 24750



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 2/97 (2%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R   +  G    L  ++ G P P V W+K  +      R+     G++  L +  A   D
Sbjct: 10921 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK--LEIRNAAHED 10978

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
              G+Y     N AG    +  V VL+ P    +L+ +E
Sbjct: 10979 GGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSE 11015



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 75/311 (24%), Positives = 119/311 (38%), Gaps = 33/311 (10%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP + E+ K  KN++ + W  P     +    Y LE+++  S  W +    E      
Sbjct: 20761 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLK-ETIRDTR 20819

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH---VVFHGSAHLV----PTARL---------VA 620
                  +    DY++R+C V+  G+ P      F+ +A  +    P A++         + 
Sbjct: 20820 QKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT 20879

Query: 621   GLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHR 680
                   VYDG  AV    +  I QG      EE  +   +G+V          + G+ + 
Sbjct: 20880 LGWSKPVYDGGSAVTGY-VVEIRQG----EEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 20934

Query: 681   LILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERV-VLTCE 739
               + AV     G  +  + P VQ   A  I E+P   L    R S+     E V VL   
Sbjct: 20935 FRVSAVNCAGQGEPIEMNEP-VQ---AKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPF 20990

Query: 740   LSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE-GV----S 794
               R     TW KD + +       ++       L +P+    D+G++    E GV    S
Sbjct: 20991 KGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKS 21050

Query: 795   AFFGVTVQDPP 805
             +   V V D P
Sbjct: 21051 STVSVKVLDTP 21061



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 5/103 (4%)

Query: 492  AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
            A E  + +G     + +  K  +  PPGPP   E     K+ V LTW  P+    +P   
Sbjct: 7553 AAENMYGVGEPVQASPITAK-YQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITG 7611

Query: 551  YRLERQEVGSEDWIQCFSIE-KAGAVEVPGDCVPSEGDYRFRI 592
            Y +ER +  ++ W++C  +  K     V G  + ++  YRFR+
Sbjct: 7612 YWVERLDPDTDKWVRCNKMPVKDTTYRVKG--LTNKKKYRFRV 7652



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 34/164 (20%), Positives = 71/164 (43%), Gaps = 17/164 (10%)

Query: 823   ECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA 881
             E   L+C++     P ++WY+ G+E+ +S    + ++G    L +   +  D G + C+A
Sbjct: 24243 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24302

Query: 882   GDECAYFTVTITDVSSWIV----------YPSGKVYVAAVRLERVVLTCELCRPWAEVRW 931
              +E     V   + SS ++          YP  + Y  AV     +    + RP   + W
Sbjct: 24303 TNE-----VGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW 24357

Query: 932   TKDGEEVVESPALLLQKEDTVRRLVLPAVQLE-DSGEYLCEIDD 974
                 + +  S  + ++  +    LV+  VQ +  +G+Y  ++ +
Sbjct: 24358 FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSN 24401



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 516  SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
            SPPGPPI   +      T+ L W+PP        + Y +++Q VG+ +W +C   EK   
Sbjct: 8696 SPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC--TEKMIK 8752

Query: 575  VEVPGDCVPSEG-DYRFRICTVSGHGRSP 602
            V         EG DY+ R+  V+  G  P
Sbjct: 8753 VRQYTVKEIREGADYKLRVSAVNAAGEGP 8781



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 32/91 (35%), Positives = 43/91 (47%), Gaps = 7/91 (7%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPE---PAPETPFIYR-LERQEVGS--EDWIQCFSIE 570
            PP PPI  ++    KNTV L+WKPP+    +P T +I   L     G+  E W QC   +
Sbjct: 9706 PPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRD 9765

Query: 571  KAGAVEVPGDCVPSEGDYRFRICTVSGHGRS 601
                     D V   G+Y FR+  V+  G S
Sbjct: 9766 VEELQFTVEDLVEG-GEYEFRVKAVNAAGVS 9795



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 43/144 (29%), Positives = 52/144 (36%), Gaps = 17/144 (11%)

Query: 93    AYAAAAVTVLEPPA-SDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRA 151
             A A  AV +  P   SDP    AE   P           LT      V  G  V L    
Sbjct: 12961 AIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLT------VKAGTNVCLDATV 13014

Query: 152   GGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHA 211
              G P PT+ W+KDG  L    +    A+Q             L + +    DSG Y   A
Sbjct: 13015 FGKPMPTVSWKKDGTLLKPA-EGIKMAMQRNLC--------TLELFSVNRKDSGDYTITA 13065

Query: 212   RNAHGHAQAGALLQVHQPPESPPA 235
              N+ G   A   L+V   P  PPA
Sbjct: 13066 ENSSGSKSATIKLKVLDKP-GPPA 13088



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 8/109 (7%)

Query: 235   ADPDEAPAPVVEPLKCAP-------KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
             +DP +   PV+      P        TF V  G+  K     +G+P P + WH +  P L
Sbjct: 15825 SDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVP-L 15883

Query: 288   PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
                 R+     +   +L +     +D G YV    NSAG+ +  + + V
Sbjct: 15884 KQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15932



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 3/100 (3%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   + V +G   ++   + G P PV+ W K G ++    R    +      L +   
Sbjct: 19488 VKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDC 19547

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLE---PPASDPEL 111
             +  D G YV   +N AG    A    VL+   PPA   E+
Sbjct: 19548 IRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEI 19587



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 11/112 (9%)

Query: 460   RWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             +W+ DG E+         +      L +    R D GE   ++ N+  +  + V      
Sbjct: 11238 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 11297

Query: 517   PPGPPI----LAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
              PGPP     + ++   H   + ++W+PP+    +P I Y +E+Q+   + W
Sbjct: 11298 VPGPPTGPINILDVTPEH---MTISWQPPKDDGGSPVINYIVEKQDTRKDTW 11346



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 3/122 (2%)

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW 538
             M  LV+P  TR+D+G+ + +L N      + V       PGP    ++    K +  ++W
Sbjct: 12355 MAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSW 12414

Query: 539   KPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
              PPE    +    Y +E++E   + W       K  +  V  + VP   +Y FR+  V+ 
Sbjct: 12415 APPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVT-NLVPG-NEYYFRVTAVNE 12472

Query: 598   HG 599
             +G
Sbjct: 12473 YG 12474



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 108/521 (20%), Positives = 190/521 (36%), Gaps = 75/521 (14%)

Query: 475   SSGHMHALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKGH 530
             SS     L++    + DAG+ T +L    G    T  ++V      P GP    E+    
Sbjct: 13728 SSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTA-- 13785

Query: 531   KNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DY 588
                + L W PP+    +    Y LE+++  +  W+ C S  +     V       EG +Y
Sbjct: 13786 -EAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTR---LHEGMEY 13841

Query: 589   RFRICTVS----GHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
              FR+   +    G G     +       VP A     + DV+ +D     ++    T   
Sbjct: 13842 TFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVR-HDSVSLTWTDPKKT--- 13897

Query: 645   GTWFLNGEELKSNEPEGQVEPGALRYRIEQK---------GLQHRLILHAVKHQDSGALV 695
             G   + G  L+  E    +   A +  I  +         GL++   + A+       L 
Sbjct: 13898 GGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAIN------LA 13951

Query: 696   GFSCPGVQDSAALTIQE-----SPVHILSPQDRVSLTFTTSE----RVVLTCELSRVDFP 746
             G   P +     + +        P  I   ++ V+L +T  +      +    + + D P
Sbjct: 13952 GVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLP 14011

Query: 747   A-TWYKDGQ-KVEESELLVVKM-DGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
             + +W K     V E    V  + +G K+   +  AK   +G     +E           +
Sbjct: 14012 SKSWMKANHVNVPECAFTVTDLVEGGKYEFRI-RAK-NTAGAISAPSESTETIICKDEYE 14069

Query: 804   PPVHIVDPREHVFVHAITSECVML-ACEVDREDAPVR-WYKDGQEVEESDFVVLENEGPH 861
              P  ++DP     +     + ++L A  +  +  P   W K G+++  SD   + +    
Sbjct: 14070 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 14129

Query: 862   RRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVV 917
               L +      D GE+   A    G +  +  VT+ DV      P G V ++ V  E+  
Sbjct: 14130 SMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPG----PPGPVEISNVSAEKAT 14185

Query: 918   LTCELCRPWAEVRWT---KDGEEVVESPALLLQKEDTVRRL 955
             LT           WT   +DG   ++S   +L+K +T R L
Sbjct: 14186 LT-----------WTPPLEDGGSPIKS--YILEKRETSRLL 14213



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 43/170 (25%), Positives = 66/170 (38%), Gaps = 14/170 (8%)

Query: 253   KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP--DRRRLMYRDRDGGFVLKVLYCQ 310
             KT +V  G++ +F   +   PEP + W+  G+ + P  + ++  +    G + L +    
Sbjct: 25394 KTAYV--GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVT 25451

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHV--------KEPRLRFTRPLQDVEGREHGIAVLEC 362
               D   Y   ARN  G+     +L V           R  F R L + E +E      E 
Sbjct: 25452 TDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEI 25511

Query: 363   KVPNSRIPT-AWFREDQRLLPCRKYEQIEEG-TVRRLIIHRLKADDDGIY 410
             +V     PT  W ++ Q L      E I EG     L I     +D G Y
Sbjct: 25512 RVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 25561



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 12/128 (9%)

Query: 119  PSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAG----------GLPEPTLYWEKDGMAL 168
            PS  +GE     +      ++  GA+  L C+AG          G P P   WE DG A 
Sbjct: 9487 PSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAK 9546

Query: 169  DEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ 228
              + D  H   +  + E    +S+ + I   +   +G Y   A+N  G   A   ++V  
Sbjct: 9547 KAMKDGVHDIPEDAQLETAENSSVII-IPECKRSHTGKYSITAKNKAGQKTANCRVKVMD 9605

Query: 229  PPESPPAD 236
             P  PP D
Sbjct: 9606 VP-GPPKD 9612



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 27/131 (20%)

Query: 124   GEGAPVFLTGP----------------RSQWVLR-GAEVVLTCRAGGLPEPTLYWEKDGM 166
             G+G P F T P                R +  +R G    LT R  G P+P + W KD  
Sbjct: 10493 GQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEA 10552

Query: 167   ALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
              + E  D +H    P        A+LAL  + A+  DSG Y     N+ G  +    + V
Sbjct: 10553 DVLED-DRTHIKTTP--------ATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNV 10603

Query: 227   HQPPESPPADP 237
                P  PP  P
Sbjct: 10604 VDRP-GPPVGP 10613



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 2/86 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAGAV 575
             P PP+  E      N+V LTW+PP     +  + Y +E Q+VG E+W +   + E     
Sbjct: 10808 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 10867

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             +     +     Y+FR+  V+  G S
Sbjct: 10868 KYKVTGLRDGQTYKFRVLAVNAAGES 10893



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 43/154 (27%), Positives = 67/154 (43%), Gaps = 19/154 (12%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP         K  V L W  P+    +P   Y +E QE G++DWI+  ++     V
Sbjct: 11104 PPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECV 11163

Query: 576   EVPGDCVPSEGDYRFRIC--TVSGHGRSPHVV-FHGSAHLVPTARLVAGLEDVQVYDG-- 630
              V G  +     YRFR+    + G G     +       LVP +  +    DV++ +G  
Sbjct: 11164 -VTG--LQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVEL----DVKLIEGLV 11216

Query: 631   EDAVFSLDLSTIIQGT------WFLNGEELKSNE 658
               A  ++    II+G       W  +G E+K++E
Sbjct: 11217 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE 11250



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 4/113 (3%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILA-EMFKGHKNTVLLTWK- 539
             L++  VTR+D+G  + +  NS  T   ++K V    PGPP    ++     +   L+W  
Sbjct: 12651 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHI 12710

Query: 540   PPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
             P E        Y +E+ +V   DW+   +     +  V G  +P + +Y FR+
Sbjct: 12711 PLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRV-GKLIPGQ-EYIFRV 12761



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 42/163 (25%), Positives = 63/163 (38%), Gaps = 22/163 (13%)

Query: 453   LEAGVEGR------WSRDGEELPVICQ----SSSGHMHALVLPGVTREDAGEVTFSLGNS 502
             LEA + G+      WS+DG+EL          S+     LV+    R D G+    L N 
Sbjct: 18422 LEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV 18481

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKPP-EPAPETPFIYRLERQEVGS 560
               T  + +       PGPP       G       L W PP +        Y +E++E   
Sbjct: 18482 GGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSR 18541

Query: 561   EDWIQCFSIEKAGAVEV----PGDCVPSEGDYRFRICTVSGHG 599
               W Q  +  +A   +V    PG+      +Y FR+  V+ +G
Sbjct: 18542 LSWTQVSTEVQALNYKVTKLLPGN------EYIFRVMAVNKYG 18578



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 39/171 (22%), Positives = 71/171 (41%), Gaps = 12/171 (7%)

Query: 1005  ECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC-- 1061
             E   L C++     P ++WY+ G E+ +S    +  DG    L +   + ED G + C  
Sbjct: 24243 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24302

Query: 1062  --DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQV---RWYK 1116
               + G+      + + A P+   HP     + ++GA G   LR  V   G  V    W+ 
Sbjct: 24303 TNEVGEVETSSKLLLQATPQ--FHPGYPLKEKYYGAVGST-LRLHVMYIGRPVPAMTWFH 24359

Query: 1117  DGLEVEASDALQLGAEGPTRTLTLPHAQPE-DAGEYVCETRHEAITFNVIL 1166
                 ++ S+ + +        L + + Q +  AG+Y  +  +   T + IL
Sbjct: 24360 GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAIL 24410



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 6/112 (5%)

Query: 231 ESPPADPDEAPAPVVEP-----LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
           E+   +    PAPV  P     L    K   V EG+     C++ G P P + W+ E   
Sbjct: 877 EAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 936

Query: 286 LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
            +          + G   L +    A+D G + C+A N AG   ++  L V+
Sbjct: 937 -IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 30/120 (25%), Positives = 52/120 (43%), Gaps = 4/120 (3%)

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKP 540
            LV+P   R D G  T +  N+  T    ++      PGPP+    F+    + + L+W P
Sbjct: 9876 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFP 9935

Query: 541  PEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
            P+    +    Y +E++E   + W+   S  K     +P   +    +Y FRI   + +G
Sbjct: 9936 PKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPK--LLEGHEYVFRIMAQNKYG 9993



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 3/91 (3%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFS 568
             C    PPGPPI  ++    + T  L W  P     +P + Y +E Q+ G+  W  I    
Sbjct: 11493 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11552

Query: 569   IEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
             + +  A  VPG    +E  +R +   + G G
Sbjct: 11553 LIRQCAFRVPGLIEGNEYRFRIKAANIVGEG 11583



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 71/336 (21%), Positives = 122/336 (36%), Gaps = 30/336 (8%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P  P  A + K +K+ + + W  P+    +P I Y +ER+E  S  W++  +     + E
Sbjct: 12787 PSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKA-NDTLVRSTE 12845

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSP------------HVVFHGSAHLVPTARLVAGLED 624
              P   +    +Y FRI  ++  G SP             V   G   ++   +    L  
Sbjct: 12846 YPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIW 12905

Query: 625   VQ-VYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI 682
              +  +DG   +    +    + G  ++         P+ +     L    E+   Q R I
Sbjct: 12906 ARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLE---EKAQYQFRAI 12962

Query: 683   LHAVKHQDSGALVGFSCPG-VQDSAALTIQESPVHI-LSPQDRVSLTFTTSERVVLTCEL 740
                         V  S P    D   +  +  P  I LS   +  LT      V L   +
Sbjct: 12963 ARTA--------VNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 13014

Query: 741   SRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGV 799
                  P  +W KDG  ++ +E + + M      L L     +DSG++    E  S     
Sbjct: 13015 FGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSA 13074

Query: 800   TVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
             T++   +    P   V ++ + S+  ML+ E   ED
Sbjct: 13075 TIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLED 13110



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 22/71 (30%), Positives = 30/71 (42%)

Query: 35    VLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAY 94
             +LG+P P   W K G+ +  S+     +      L +  A   DAG Y   A N  G   
Sbjct: 14098 ILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKV 14157

Query: 95    AAAAVTVLEPP 105
                 VTVL+ P
Sbjct: 14158 EHVKVTVLDVP 14168



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query: 481   ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKP 540
             +L +    R D+G+ T ++ N  +   L +       PGPP    +    K + +L+W  
Sbjct: 19936 SLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDV 19995

Query: 541   PEPAPETPF-IYRLERQEVGSEDWI 564
             PE     P   Y +E++E   + W+
Sbjct: 19996 PENDGGAPVKNYHIEKREASKKAWV 20020



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 27/114 (23%), Positives = 51/114 (44%), Gaps = 7/114 (6%)

Query: 238   DEAPAPVVEPLKCAPKTF---WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLM 294
             DE   P+VE     P+ F    +  G+  + +  V G+P P + W  +G   +  R  + 
Sbjct: 21646 DENVPPIVE---FGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVE-IEKRMNME 21701

Query: 295   YRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQ 348
               D  G   L V       RG+Y   A+N++G   + +++ V++   +   P++
Sbjct: 21702 ITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIR 21755



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 50/248 (20%), Positives = 90/248 (36%), Gaps = 25/248 (10%)

Query: 1384  SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGT----VTLRAGSTATS 1439
             S P A+V W  NG  +    ++          L +  C   D+GT     T   G  +  
Sbjct: 26094 SKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDY 26153

Query: 1440  ARLHV-----------RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQ 1488
             A L V           R  E +      ++   E   V    +T  + A+ +VR V+   
Sbjct: 26154 ATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQM 26213

Query: 1489  PLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLED 1548
                 ++R S++   H     +    L +      +S  +++  R        R+L     
Sbjct: 26214 T---ETRESLSSYEHSASAEMKSAALEE------KSLEEKSTTRKIKTTLAARILTKPRS 26264

Query: 1549  VTISEGGSATFQLELSQEGV-TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG 1607
             +T+ EG SA F  +   E V T  W R G  L    +  + +  ++    ++ +  +D G
Sbjct: 26265 MTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEG 26324

Query: 1608  CVSFTADS 1615
               S   ++
Sbjct: 26325 NYSVVVEN 26332



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 26/108 (24%), Positives = 39/108 (36%), Gaps = 1/108 (0%)

Query: 229   PPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
             P E      D+  AP ++        +   E  + + +  + GKP P + W     PL  
Sbjct: 13661 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLAT 13720

Query: 289   DRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             D  R+          L V  CQ  D G Y    +N AG     + + V
Sbjct: 13721 D-TRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 13767



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 61/268 (22%), Positives = 96/268 (35%), Gaps = 52/268 (19%)

Query: 312   KDRGLYVCAARNSAGQTLSAVQ----LHVKEPRLRF---TRPLQDVEGREHGIAVLECKV 364
             KD  + V AAR S G  + + +      VK   +     +  +    G E G     CK+
Sbjct: 25227 KDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYVCKI 25286

Query: 365   PNSRIPT--AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM---RGRVR 419
              N    T   W+   ++L    KYE   E  V  L +  +   DDG Y C++    G   
Sbjct: 25287 ENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 25346

Query: 420   TVANVTVKG----------PILKRLPRKLDVLE-------------------GENAVLLV 450
             + A + VKG            +K++ R+ D +                    GEN    V
Sbjct: 25347 SYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGV 25406

Query: 451   E-TLEAGVEGRWSRDGEEL-------PVICQSSSGHMHALVLPGVTREDAGEVTFSLGN- 501
               T+       W + G+++           +S  G ++ L +  VT +D  E T    N 
Sbjct: 25407 TITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG-LYQLTINSVTTDDDAEYTVVARNK 25465

Query: 502   -SRTTTLLRVKCVKHSPPGPPILAEMFK 528
                 +   ++    H PP    L  MFK
Sbjct: 25466 YGEDSCKAKLTVTLHPPPTDSTLRPMFK 25493



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 5/116 (4%)

Query: 223   LLQVHQPPESPP---ADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIE 278
             ++ V++   S P   A P  A   V+EP +K A  ++ V  G+  K    + G+P+P I 
Sbjct: 16898 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 16957

Query: 279   WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             W  +G P L    R+   D      L +      D G Y     N  GQ  +++++
Sbjct: 16958 WTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEI 17012



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 1284  GGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCD 1342
             G DL++ + + G   P + W KDGE L    RV +E+     VL ++     D G+Y   
Sbjct: 18021 GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVT 18080

Query: 1343  A 1343
             A
Sbjct: 18081 A 18081



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V+ G   +   YV GKP P + W+   R  LP    +         V+K   CQ   +G+
Sbjct: 10231 VHAGGVIRIIAYVSGKPPPTVTWNMNER-TLPQEATIETTAISSSMVIK--NCQRSHQGV 10287

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y   A+N AG+    + + V
Sbjct: 10288 YSLLAKNEAGERKKTIIVDV 10307



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 32/80 (40%), Gaps = 1/80 (1%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V  G   +F   + G P P  +W  +G  +  D    +  D     VL +  C  +D G 
Sbjct: 11217 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS-VLTIKNCLRRDTGE 11275

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y     N+AG    AV L V
Sbjct: 11276 YQITVSNAAGSKTVAVHLTV 11295



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 1/68 (1%)

Query: 1274  AAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
             A +T V +  G D+++++   G P   V W KD + L S  R  +E   +  +L +    
Sbjct: 20971 ALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVT 21030

Query: 1333  SGDAGEYL 1340
               D G+Y+
Sbjct: 21031 RNDTGKYI 21038



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 1/50 (2%)

Query: 518  PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
            P PP+        +++V L W+PP     +P + Y +ER E G ++WI+C
Sbjct: 6987 PSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 7036



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 4/92 (4%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
             +PPG P    +    + +V L W  PE    +    Y +E Q+V   +W +C +      
Sbjct: 23726 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKC-NTTPTKI 23784

Query: 575   VEVPGDCVPSEGDYRFRI--CTVSGHGRSPHV 604
              E     +P   +YRFR+  C   G G    V
Sbjct: 23785 REYTLTHLPQGAEYRFRVLACNAGGPGEPAEV 23816



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)

Query: 19   RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
            + V V    +A  +CV+  E    V+W KG   + +S++    ADG +H L++  +   D
Sbjct: 5188 KDVTVPERRQARFECVLTREAN--VIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDD 5245

Query: 79   AGVY 82
             GVY
Sbjct: 5246 EGVY 5249



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 3/106 (2%)

Query: 231  ESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
            E    D  EAP   ++    A  T  V  G   +    V GKPEP+I W  +   +L   
Sbjct: 7373 EIQAVDTQEAPEIFLDVKLLAGLT--VKAGTKIELPATVTGKPEPKITW-TKADMILKQD 7429

Query: 291  RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            +R+   +      + ++  +  D G Y+  A N  G+  + V+++V
Sbjct: 7430 KRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7475



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 17/49 (34%), Positives = 29/49 (59%), Gaps = 1/49 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQ 565
             PGPP   ++F   ++ + LTW PPE    +    Y +ER+EV ++ W++
Sbjct: 23627 PGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVR 23675



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 6/88 (6%)

Query: 1725  LRSVSAREGDGATFECTVSEVET-TGRWELGGRPLRPGARVRIRQEG-KKHILVLSELRA 1782
             L +   +EG    FE  VS +   T +WE  G+PL  G  + I  EG   + L + +   
Sbjct: 25496 LANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLP 25555

Query: 1783  EDAGEVRF----QAGPAQSLALLEVEAL 1806
             ED G  R      AG     A L+VE L
Sbjct: 25556 EDTGYYRVTATNTAGSTSCQAHLQVERL 25583



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 518  PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFSIEKAGA 574
            PGPP   ++    K ++L++W PP     +P   Y LE++E GS  W  +    I K G 
Sbjct: 9294 PGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGL 9353

Query: 575  VEVPGDCVPS--EG-DYRFRICTVSGHGRSP 602
              V  + VP   EG  Y+FR   ++  G  P
Sbjct: 9354 KGVEFN-VPRLLEGVKYQFRAMAINAAGIGP 9383



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 129/621 (20%), Positives = 223/621 (35%), Gaps = 84/621 (13%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PP PP    +    + +  L W+ PE    +  + Y +E Q  G+E W      +   AV
Sbjct: 17907 PPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAV 17966

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS-PHV----VFHGSAHLVPTARLVAGLEDVQVYDG 630
              V G  + S  +Y+FR+   +  G+S P V    V      + P+ +L      +Q   G
Sbjct: 17967 -VTG--LSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQA--G 18021

Query: 631   EDAVFSLDLSTIIQG----TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
             ED    +++  I +     +W  +GE LK             R  +E+      L +   
Sbjct: 18022 ED--LKIEIPVIGRPRPNISWVKDGEPLKQ----------TTRVNVEETATSTVLHIKEG 18069

Query: 687   KHQDSG---ALVGFSCPGVQDSAALTIQESPVHILSPQ--DRVSLTFT--TSERVVLT-- 737
                D G        S     ++ ++ + E P   + P   D VS  F   + E    T  
Sbjct: 18070 NKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGG 18129

Query: 738   CELS------RVDFPATWYKDGQKVEESELLVVKM-DGRKHRL-ILPEAKVQDSGEFECR 789
             C++S      R     TW+     V  + + + K+  G +++  I  E +   S   + +
Sbjct: 18130 CQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSK 18189

Query: 790   TEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR--WYKDGQEV 847
                        +   P     P    FV +I+ + +++       D   +   Y   Q+ 
Sbjct: 18190 ---------AVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKE 18240

Query: 848   EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY-----P 902
             + S   V  N+ P +      T   +G E++     E        + VS   V      P
Sbjct: 18241 KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP 18300

Query: 903   SGKVYVAAVRLERVVLT---------CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVR 953
              G+     +    V L           ++     E +   DG  +  S   +L+ E TV 
Sbjct: 18301 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 18360

Query: 954   RLV------LPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECV 1007
              LV         +    +G +    D   A       + P   + P+ +  ++    E  
Sbjct: 18361 GLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETF 18420

Query: 1008  VLMCELSREDAP-VRWYKDGLEVEESEA-LVLERDGPRCRLVLPAAQPEDGGEFVCD--- 1062
             VL  ++  +  P V W KDG E+EE+ A + ++    +  LV+      DGG+++     
Sbjct: 18421 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 18480

Query: 1063  -AGDDSAFFTVTV---TAPPE 1079
               G  S   TV V     PPE
Sbjct: 18481 VGGTKSIPITVKVLDRPGPPE 18501



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/146 (20%), Positives = 63/146 (43%), Gaps = 7/146 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DGE L    +     +     L +    ++D G+ T +  NS  T    +  +    
Sbjct: 18040 WVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 18099

Query: 518   PGPPILAEMF-KGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PGPP+    F +   + V+++W+PP          Y +E+++  +  W    +      +
Sbjct: 18100 PGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTI 18159

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             ++    + +  +Y+FRI   + +G+S
Sbjct: 18160 KITK--LKTGTEYQFRIFAENRYGKS 18183



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 190/979 (19%), Positives = 339/979 (34%), Gaps = 168/979 (17%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQ---EVGSEDWIQC-FSIEKA 572
             PG P + ++ +   +TV L W  P     +  + Y +ER+   EVG   W++C ++I   
Sbjct: 22637 PGRPEVTDVTR---STVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSD 22693

Query: 573   GAVEVPGDCVPSEGD-YRFRICTVSGHG------RSPHVVFHGSAHLVPTARLVAGLED- 624
                 V      SEGD Y FR+   +  G       S   V     +  P A L A L   
Sbjct: 22694 NFFTVTA---LSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGD 22750

Query: 625   -VQVYDGEDAVFSLDLSTIIQGT------WFLNGEELKSNEPEGQVEPGALRYRIEQKGL 677
              V +  G D V    L   + G       W    +EL   E          +  ++  G 
Sbjct: 22751 LVTIRAGSDLV----LDAAVGGKPEPKIIWTKGDKELDLCE----------KVSLQYTGK 22796

Query: 678   QHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
             +   ++      DSG     +      + A+++    +    P  +++++  T E+  L 
Sbjct: 22797 RATAVIKFCDRSDSGKYT-LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLA 22855

Query: 738   CELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
               L + D  A   +   ++ E S L  V ++G    L     ++  + E+  R   V+ +
Sbjct: 22856 WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKY 22915

Query: 797   F-GVTVQDPPV----------------HIVDPREHVFVHAITSEC-----VMLACEVDRE 834
               GV V+  P+                 +   +EH+ +     E      +       RE
Sbjct: 22916 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKRE 22975

Query: 835   DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
                +RW +  +     D+VV +         L  T   +G ++Q       A      ++
Sbjct: 22976 KKSLRWTRVNK-----DYVVYDTR-------LKVTSLMEGCDYQFRVTAVNAAGNSEPSE 23023

Query: 895   VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTK---DGEEVVESPALLLQKEDT 951
              S++I               RVV T +       + WTK   DG   +    L +Q++DT
Sbjct: 23024 ASNFISCREPSYTPGPPSAPRVVDTTKHS---ISLAWTKPMYDGGTDIVGYVLEMQEKDT 23080

Query: 952   -----------VRRLVLPAVQLEDSGEYLCEIDDESA------SFTVTVTEPPVRIIYPR 994
                        +R        L+   +Y   +   +       S ++   EP  RI  P 
Sbjct: 23081 DQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPD 23140

Query: 995   DEVT---LIAVTLEC---VVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLV 1047
              E+       VT+     + LM  +S    PV  W K G+++  +   +++       L+
Sbjct: 23141 LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDL--ASRAIIDTTESYSLLI 23198

Query: 1048  LPAAQPEDGGEFVCDAGDDSAFFTVTVTA---------PPERIVHPAARSLDLHFGAP-- 1096
             +      D G++  +A + S   + TV           P  ++   +  S+ + +  P  
Sbjct: 23199 VDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 23258

Query: 1097  --GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDA---GEY 1151
               G       V    + +R +K  +  + S  L   +     T+      PE+    GE 
Sbjct: 23259 DGGAPVNNYIVEKREAAMRAFKT-VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE- 23316

Query: 1152  VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVV--------LSCELSRAGA- 1202
              CET    +   V L   P +   ++ T S + +A  +P+            E  +AG  
Sbjct: 23317 PCETSDAVLVSEVPLV--PAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTE 23374

Query: 1203  ---------PVVWSHNGRPVQEGEG--LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAP 1251
                      P V  H    + EGE     + A+  + V                   + P
Sbjct: 23375 RWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGV-------------------SEP 23415

Query: 1252  GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA 1310
                  + TVQ       +      Q  +    G  +ELV+ ++G P     W+  G +L 
Sbjct: 23416 RETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR 23475

Query: 1311  SQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLT 1370
                RV +E       L ++     D GEY  +    +     +++  +L K      P+ 
Sbjct: 23476 ESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIK 23535

Query: 1371  VHEGDDATFRCEVSPPDAD 1389
             + E D  +      PP+ D
Sbjct: 23536 IDEIDATSITISWEPPELD 23554



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 50/188 (26%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 705 SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVV 764
           SA  + Q+    + +P  + S T   +E   L  +    D P T YK    VE  + + V
Sbjct: 801 SATSSAQKITKSVKAPTVKPSETRVRAEPTPLP-QFPFADTPDT-YKSEAGVEVKKEVGV 858

Query: 765 KMDG---RKHRLIL---PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
            + G   R+ R  +    EAKV ++       E         +   P  +V   ++V V 
Sbjct: 859 SITGTTVREERFEVLHGREAKVTETARVPAPVE---------IPVTPPTLVSGLKNVTV- 908

Query: 819 AITSECVMLACEVDREDAP-VRWYKDGQEVEES-DFVVLENEGPHRRLVLPATQPSDGGE 876
            I  E V L C +    +P V WY++  ++E S DF +    G   RL++      D G 
Sbjct: 909 -IEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG-IARLMIREAFAEDSGR 966

Query: 877 FQCVAGDE 884
           F C A +E
Sbjct: 967 FTCSAVNE 974



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 3/92 (3%)

Query: 332 VQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIE 390
           V++ V  P L     L++V   E     LEC +     PT  W+RED ++     ++   
Sbjct: 890 VEIPVTPPTL--VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 391 EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
           +  + RL+I    A+D G + C       TV+
Sbjct: 948 QSGIARLMIREAFAEDSGRFTCSAVNEAGTVS 979



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 33/111 (29%), Positives = 46/111 (41%), Gaps = 7/111 (6%)

Query: 229  PPESPP---ADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
            P E+ P   A+P E PA  VE          +  GK  +    V G+P P   W  E   
Sbjct: 8782 PGETQPVTVAEPQEPPA--VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGE 8839

Query: 286  LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            L  D+ R++  +      L +     KD G YV  A NS G   +A ++ V
Sbjct: 8840 L--DKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 8888



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 23/83 (27%), Positives = 35/83 (42%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    +   V G+PPP V W    + L     +   A  +   +++     +  GVY
Sbjct: 10231 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSS--MVIKNCQRSHQGVY 10288

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+N AGE      V VL+ P
Sbjct: 10289 SLLAKNEAGERKKTIIVDVLDVP 10311



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 21/90 (23%), Positives = 36/90 (40%), Gaps = 2/90 (2%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
             G + +++  + G P P + W K G  L  + R++         L +      D G Y   
Sbjct: 16939 GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGIT 16998

Query: 86    ARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
               N  G+  A+  +  L+ P  DP   P +
Sbjct: 16999 VANVVGQKTASIEIVTLDKP--DPPKGPVK 17026



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 93/414 (22%), Positives = 145/414 (35%), Gaps = 55/414 (13%)

Query: 226   VHQPPES--PPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             + +P +S  P    DE   P +        T  VN G+  +    V GKP P IEW   G
Sbjct: 17299 ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW-LRG 17357

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV------- 336
                + +  R   ++ D   +L V      D G Y+  A N AG     V + V       
Sbjct: 17358 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17417

Query: 337   -----------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW-FREDQRLLPCR 384
                        ++  L ++ PLQD  G +    V+E K   SR+  AW     + +    
Sbjct: 17418 EGPVQVTGVTSEKCSLTWSPPLQD-GGSDISHYVVE-KRETSRL--AWTVVASEVVTNSL 17473

Query: 385   KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP-ILKRLPRKLDVLEG 443
             K  ++ EG     +   +  +  G+      G     A V +K P +L   P+ L+V   
Sbjct: 17474 KVTKLLEG--NEYVFRIMAVNKYGV------GEPLESAPVLMKNPFVLPGPPKSLEVTNI 17525

Query: 444   ENAVLLV-----------ETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDA 492
                 + V           E +   VE R  R G    + C         L + G+T +  
Sbjct: 17526 AKDSMTVCWNRPDSDGGSEIIGYIVEKR-DRSGIRW-IKCNKRRITDLRLRVTGLTEDHE 17583

Query: 493   GEVTFS------LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW-KPPEPAP 545
              E   S      +G     T+    C     PGPP  A +    KN++ L W KP     
Sbjct: 17584 YEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGG 17643

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                  Y +E  +   E+W                  +    +Y+ R+C ++  G
Sbjct: 17644 SEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVG 17697



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
             V + DAG+   +L NS       +       PGPP+   + +  K++  +TW+PP     
Sbjct: 13451 VNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGG 13510

Query: 547   TPFI-YRLERQEVGSEDW 563
             +P I Y +++++   + W
Sbjct: 13511 SPIINYVVQKRDAERKSW 13528



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 4/91 (4%)

Query: 514   KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKA 572
             +  PPGPP   E+    KNT  ++WK P     +    Y +ER+E  S  W++      +
Sbjct: 14263 RFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVS 14322

Query: 573   G-AVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
                 +V G  +     Y FR+   +  G  P
Sbjct: 14323 DLRCKVTG--LQEGSTYEFRVSAENRAGIGP 14351



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 1/82 (1%)

Query: 461   WSRDGEELPVICQSSSGHMHA-LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
             WSR+  E     Q   G  +  L +    R DAG+    L NS  +    V       PG
Sbjct: 17753 WSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPG 17812

Query: 520   PPILAEMFKGHKNTVLLTWKPP 541
             PP    + +  K++  L W+PP
Sbjct: 17813 PPQNLAVKEVRKDSAFLVWEPP 17834



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 18/64 (28%), Positives = 28/64 (43%), Gaps = 3/64 (4%)

Query: 1657  ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAG---PVRLT 1713
             A V W KDG  L  + R+ + +  T   L ++     D GTY   V  +      P+ + 
Sbjct: 19119 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITII 19178

Query: 1714  VRER 1717
             V +R
Sbjct: 19179 VLDR 19182



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 269   VMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQ 327
             V GKPEP+I W    + L L ++  L Y  +    V+K  +C   D G Y    +N++G 
Sbjct: 22766 VGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIK--FCDRSDSGKYTLTVKNASGT 22823

Query: 328   TLSAVQLHV 336
                +V + V
Sbjct: 22824 KAVSVMVKV 22832



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 22/81 (27%), Positives = 30/81 (37%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G    L   V G PPP + W K    L     L   +   +  L        DAG Y+ 
Sbjct: 13402 AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYIL 13461

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N+ G+      V VL+ P
Sbjct: 13462 TLENSCGKKEYTIVVKVLDTP 13482



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 8/102 (7%)

Query: 1351  LVSVEEPLLVKLVSELTPLTVHEGDDATFRCE-VSPPDADVTWLRNGAVVTPGPQVEMAQ 1409
             L S E P + K   E+  +T   G+ A   C+ V  P  D+ W R G  +    + +M+ 
Sbjct: 24222 LTSGEAPGIRK---EMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSS 24278

Query: 1410  NGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRET 1447
             +G +  LT+   +  D G  T  A    G   TS++L ++ T
Sbjct: 24279 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 24320



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 10/128 (7%)

Query: 1775  LVLSELRAEDAGEVRFQAGPAQS---LALLEVEALPLQMCRHPPREKTVLVGRRAVLEVT 1831
             +V+S  R    G +R Q G + +   +A +E+  +  Q+  H   E+   V  + V ++ 
Sbjct: 25231 MVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIM-HAVGEEGGHV--KYVCKIE 25287

Query: 1832  VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDST 1887
                    V W     +L   +KYE+        L + D+   D GTY C+     G+DS+
Sbjct: 25288 NYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS 25347

Query: 1888  HTRLLVEG 1895
             +  L V+G
Sbjct: 25348 YAELFVKG 25355



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 51/238 (21%), Positives = 89/238 (37%), Gaps = 41/238 (17%)

Query: 965   SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
             S EY   +  E+    V V+EPP+    P   VTL+ VT           R  A ++W K
Sbjct: 18970 SNEYGIGLPAETTE-PVKVSEPPL----PPGRVTLVDVT-----------RNTATIKWEK 19013

Query: 1025  ---DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVT----AP 1077
                DG        + ++  G          +  +       AG++  F    V     + 
Sbjct: 19014 PESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSD 19073

Query: 1078  PERIVHPA-ARSLDLH---------FGAPGRVELRCEVAPAG---SQVRWYKDGLEVEAS 1124
             P ++  P  AR +++          F    R +L+ +V   G   + V W KDG  ++ +
Sbjct: 19074 PRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKET 19133

Query: 1125  DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
               + + +     +L++  A  ED G Y     + A +  V     P+  + L+    P
Sbjct: 19134 TRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITV-----PITIIVLDRPGPP 19186



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 8/116 (6%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKH-SPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
             V  E+A  V  + G SR      +KC +  +PPGPP + ++    K TV L W  P    
Sbjct: 21922 VMAENAAGVGPASGISRL-----IKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDG 21976

Query: 546   ETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
                 I Y +E  +    DW +  + E           + +  +Y+FR+  ++G G+
Sbjct: 21977 GMEIIGYIIEMCKADLGDWHK-VNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 22031



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 30/114 (26%), Positives = 48/114 (42%), Gaps = 7/114 (6%)

Query: 489  REDAGEVTFSLGN--SRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
            R D G       N   R T ++ V  +    PGPP   ++      + LLTW PP     
Sbjct: 7450 RSDTGTYIIEAVNVCGRATAVVEVNVL--DKPGPPAAFDITDVTNESCLLTWNPPRDDGG 7507

Query: 547  TPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
            +    Y +ER+   SE W +  S  K    +     +P++ +Y FR+   + +G
Sbjct: 7508 SKITNYVVERRATDSEVWHKLSSTVKDTNFKAT-KLIPNK-EYIFRVAAENMYG 7559



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 19/79 (24%), Positives = 36/79 (45%)

Query: 925  PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT 984
            P   V W KDG+EV  S  L ++ +     L +P     D+G Y   ++++  S T ++ 
Sbjct: 8109 PVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASIN 8168

Query: 985  EPPVRIIYPRDEVTLIAVT 1003
               + +  P  ++    +T
Sbjct: 8169 VKVIGLPGPCKDIKASDIT 8187



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 16/55 (29%), Positives = 30/55 (54%)

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
            V W+KDG+EV+ SD + ++N+     L +P +  +D G +     ++    T +I
Sbjct: 8113 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASI 8167



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 17/40 (42%), Positives = 24/40 (60%)

Query: 1112 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
            V W+KDG EV+ASD L +  +  +  L +P +   DAG Y
Sbjct: 8113 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 8152



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 18/57 (31%), Positives = 29/57 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT 980
             +P    +W K  +EVV S  L + K D+   L++  V  +DSG Y    ++ S + T
Sbjct: 12620 KPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDT 12676



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 15/149 (10%)

Query: 748   TWYKDGQKV---EESELLVVKMDGRKHRLILPEAKVQDSGEF------ECRTEGVSAFFG 798
             TWYK GQK+   +  +    + D   ++L +      D  E+      +   +   A   
Sbjct: 25417 TWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLT 25476

Query: 799   VTVQDPPVH--IVDPREHVFVHAITSECVMLACEVDREDAP---VRWYKDGQEVEESDFV 853
             VT+  PP    +    + +  +A   E   +  E+     P   ++W KDGQ +     +
Sbjct: 25477 VTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNI 25536

Query: 854   VLENEG-PHRRLVLPATQPSDGGEFQCVA 881
              + +EG  +  L +  T P D G ++  A
Sbjct: 25537 EIIHEGLDYYALHIRDTLPEDTGYYRVTA 25565



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 18   PRPVRVVSGAEAELKC--------VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            PRP+ ++ G   +  C        V +       VW K GQ++  S+R+    D   H L
Sbjct: 2307 PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2366

Query: 70   LLTAALPTDAGVY 82
            L+      DAG Y
Sbjct: 2367 LIEDMTKEDAGNY 2379



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 18/60 (30%), Positives = 30/60 (50%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             LV+  VTR D+G    +L N+  +    V       P  P+   + +  K++V L+W+PP
Sbjct: 18858 LVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPP 18917



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 41/171 (23%), Positives = 64/171 (37%), Gaps = 28/171 (16%)

Query: 63    DGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             D +E    +T   P D   +   ARNA G        T+  P  S   +   +  +P   
Sbjct: 21602 DVSECQYTVTGLSPGDRYEFRIIARNAVG--------TISPPSQSSGIIMTRDENVP--- 21650

Query: 123   SGEGAPVFLTGPR---SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                  P+   GP       +  G  + +     G P P + W KDG+ +++  +      
Sbjct: 21651 -----PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---- 21701

Query: 180   QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPP 230
                   D  G S +L +  A     GVY   A+NA G A+A   ++V   P
Sbjct: 21702 ----ITDVLG-STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 21747



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 22/91 (24%), Positives = 41/91 (45%), Gaps = 1/91 (1%)

Query: 1183  LCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG 1241
             L +  GE + +   +     P V W  +G  +++   +E+        L ++ A   H G
Sbjct: 21663 LIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 21722

Query: 1242  LYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
             +YT ++  A G+      V+V + P +VV P
Sbjct: 21723 VYTVEAKNASGSAKAEIKVKVQDTPGKVVGP 21753



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 39/167 (23%), Positives = 65/167 (38%), Gaps = 32/167 (19%)

Query: 453   LEAGVEGR------WSRDGEELPVICQSSS----GHMHALVLPGVTREDAGEVTFSLGNS 502
             L+A V G+      W++  +EL  +C+  S    G     V+    R D+G+ T ++ N+
Sbjct: 22762 LDAAVGGKPEPKIIWTKGDKELD-LCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNA 22820

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWK-PPEPAPETPFIYRLERQEVGSE 561
               T  + V       PGP     + +  +    L W  P E        Y +ER+E    
Sbjct: 22821 SGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRL 22880

Query: 562   DWIQCFSIEKAGAVEVPGDC---------VPSEGDYRFRICTVSGHG 599
             +W           V V G+C         +    +Y FR+  V+ +G
Sbjct: 22881 NW-----------VIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYG 22916



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 1/67 (1%)

Query: 1721  VLSELRSVSAREGDGATFEC-TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
             +L++ RS++  EG+ A F C T  E   T  W   G+ L   AR ++     K    +S 
Sbjct: 26258 ILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISS 26317

Query: 1780  LRAEDAG 1786
             ++A D G
Sbjct: 26318 VQASDEG 26324



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 9/97 (9%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            V  G ++ L     G PEP + W K  M L +        +     E+ P  S  + I+ 
Sbjct: 7397 VKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITI-----ENVPKKS-TVTIVD 7447

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPA 235
            ++  D+G Y+  A N  G A A   + V   P  P A
Sbjct: 7448 SKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAA 7484



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 32/111 (28%), Positives = 44/111 (39%), Gaps = 11/111 (9%)

Query: 134   PRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193
             P    +  G ++ +     G P PT  W+K     DEV  SSH A+          +S  
Sbjct: 12600 PEQITIKAGKKLRIEAHVYGKPHPTCKWKK---GEDEVVTSSHLAVHKA------DSSSI 12650

Query: 194   LRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQP-PESPPADPDEAPA 242
             L I      DSG Y   A N+ G   Q   ++ +  P P  PP D  +  A
Sbjct: 12651 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDA 12701



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 13/89 (14%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             RP  EV+W +D  E ++  +  ++   +   L++  V   DSG+Y+  +++ S S +  V
Sbjct: 15582 RPAPEVKWARDHGESLDKAS--IESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 15639

Query: 984   TEPPVRII----YPRD----EVTLIAVTL 1004
                 VR++     P+D    EVT  +VTL
Sbjct: 15640 N---VRVLDTPGPPQDLKVKEVTKTSVTL 15665



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 1640  VTEGDTATFECEL-SQALADVTWEKDGNAL-TPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             V  G+T   E ++  + + DV W KDG  L   + R+ +++   +  L ++ C  +D G 
Sbjct: 18414 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 18473

Query: 1698  YSCA---VGTARAGPVRLTVRER 1717
             Y      VG  ++ P+ + V +R
Sbjct: 18474 YILKLSNVGGTKSIPITVKVLDR 18496



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             C  + PPGPP   E+    K+++++TW  P     T    Y LE+++     W +C
Sbjct: 18591 CNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKC 18646



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 29/119 (24%), Positives = 53/119 (44%), Gaps = 10/119 (8%)

Query: 491   DAGEVTFSLGNSRTTTLLRVKCVKHSPPGPP----ILAEMFKGHKNTVLLTWKPPE-PAP 545
             DAG    +  NS  TT   +  V    PGPP    +++++    + +V L W+PP+    
Sbjct: 20238 DAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDI---TEESVTLKWEPPKYDGG 20294

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                  Y L ++E  +  W +  +      ++V    + +  +Y+FRI   +  G S H+
Sbjct: 20295 SQVTNYILLKRETSTAVWTEVSATVARTMMKVMK--LTTGEEYQFRIKAENRFGISDHI 20351



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 24/92 (26%), Positives = 36/92 (39%), Gaps = 2/92 (2%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             R+   + V  G    L   + G+P P+  W K GQ +  S+R           L++  A 
Sbjct: 23836 RYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI--SKRAMIATSETHTELVIKEAD 23893

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS 107
               D+G Y     N  G+      V V+  P S
Sbjct: 23894 RGDSGTYDLVLENKCGKKAVYIKVRVIGSPNS 23925



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 33/158 (20%), Positives = 60/158 (37%), Gaps = 22/158 (13%)

Query: 720  PQDRVSLTFTTSERVVLTCELSRVDFP--------ATWYKDGQKVEESELLVVKMDGRKH 771
            P  + ++   T + +V+  E   +  P         +W+KDG++V+ S+ L +K D    
Sbjct: 8078 PDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISA 8137

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEV 831
             L +P++   D+G +    E        ++    + +  P + +    IT     L  E 
Sbjct: 8138 HLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEP 8197

Query: 832  DRED--APVRWYKDGQEVEESDFVVLENEGPHRRLVLP 867
               D   P+  Y            VLE     RR  +P
Sbjct: 8198 PEFDGGTPILHY------------VLERREAGRRTYIP 8223



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 1638  LEVTEGDTATFECEL-SQALADVTWEKDGNA--LTPSPRLRLQALGTRRLLQLRRCGPSD 1694
             L V  GDT   E  +  +   +V W KD +A  LT SPR+++          L +   SD
Sbjct: 11906 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSD 11965

Query: 1695  AGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV-SAREGDGATFECTV 1742
              G Y     T  AG     V   TV VL +   V + +  D ++  CTV
Sbjct: 11966 GGKY-VVTATNTAGSF---VAYATVNVLDKPGPVRNLKIVDVSSDRCTV 12010



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 17/173 (9%)

Query: 1096  PGRVELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
             PG   +RC  AP    Q  +   GLE +A    Q  A   T     P ++P D    + E
Sbjct: 12927 PGDKWVRCNTAPHQIPQEEYTATGLEEKAQ--YQFRAIARTAVNISPPSEPSDPVTILAE 12984

Query: 1155  TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPV 1213
                  I  +V +              S L V  G  V L   +     P V W  +G  +
Sbjct: 12985 NVPPRIDLSVAMK-------------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLL 13031

Query: 1214  QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
             +  EG+++  +     L + +     +G YT  +  + G+ S +  ++V + P
Sbjct: 13032 KPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 13084



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K+TV L W KP          Y +E Q  GS+ W    +++  G   
Sbjct: 14660 PSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVK--GLEC 14717

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V  +    E +Y F++  V+  GRS
Sbjct: 14718 VVRNLTEGE-EYTFQVMAVNSAGRS 14741



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 26/102 (25%), Positives = 41/102 (40%), Gaps = 8/102 (7%)

Query: 232   SPPADP-------DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGR 284
             SPP++P       D+  AP ++       T  +  G+  +    V G+P P +EW  +G+
Sbjct: 15136 SPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGK 15195

Query: 285   PLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG 326
               L    +L  +  D    L       +D G Y   A N  G
Sbjct: 15196 E-LEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGG 15236



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 20/87 (22%), Positives = 36/87 (41%)

Query: 833   REDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
             R  A V W KDGQ ++E+  V + +      L +      D G ++    +     TV I
Sbjct: 19116 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 19175

Query: 893   TDVSSWIVYPSGKVYVAAVRLERVVLT 919
             T +      P G + +  V  + + ++
Sbjct: 19176 TIIVLDRPGPPGPIRIDEVSCDSITIS 19202



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K++V LTW  PE    +  + Y +E  E G ++W++C ++ K+    
Sbjct: 20070 PSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKC-AVAKSTHHV 20128

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V G  +    +Y FR+   +  G S
Sbjct: 20129 VSG--LRENSEYFFRVFAENQAGLS 20151



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD---ESASFT 980
             RP   V W KD + +       ++  D+   L +P V   D+G+Y+  I++   E  S T
Sbjct: 20993 RPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 21052

Query: 981   VTV 983
             V+V
Sbjct: 21053 VSV 21055



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 23/89 (25%), Positives = 35/89 (39%), Gaps = 9/89 (10%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G+++VL    GG PEP + W K    LD          +      G  A+  ++      
Sbjct: 22757 GSDLVLDAAVGGKPEPKIIWTKGDKELD-------LCEKVSLQYTGKRATAVIKF--CDR 22807

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPP 230
              DSG Y    +NA G      +++V   P
Sbjct: 22808 SDSGKYTLTVKNASGTKAVSVMVKVLDSP 22836



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 2/75 (2%)

Query: 1637  DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
             D+    G+ A   C++  + L D+ W + G  L  S + ++ + G    L +      D 
Sbjct: 24236 DVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 24295

Query: 1696  GTYSCAVGTARAGPV 1710
             G Y+C + T   G V
Sbjct: 24296 GVYTC-IATNEVGEV 24309



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 18/76 (23%), Positives = 32/76 (42%)

Query: 37   GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
            G P P   W  G + L   +R+      A   L+++ +  +D G+Y  +  N        
Sbjct: 7115 GYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGE 7174

Query: 97   AAVTVLEPPASDPELQ 112
              V V+  P++  EL+
Sbjct: 7175 IDVNVIARPSAPKELK 7190



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
            PP PP   E+    KNT  L W  PE    +P   Y +E+++V  + W
Sbjct: 7778 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGW 7825



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 8/99 (8%)

Query: 25   SGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADG----AEHG--LLLTAALP 76
            +G++  +  V+ G P P   WE  G+   A +      P D     AE+   +++     
Sbjct: 9519 AGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKR 9578

Query: 77   TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
            +  G Y   A+N AG+  A   V V++ P    +L+ ++
Sbjct: 9579 SHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSD 9617



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 6/70 (8%)

Query: 924   RPWAEVRWTKDGE--EVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF-- 979
             +P+ EV WTKD +  ++  SP + +       +  L   +  D G+Y+    + + SF  
Sbjct: 11923 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVA 11982

Query: 980   --TVTVTEPP 987
               TV V + P
Sbjct: 11983 YATVNVLDKP 11992



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/81 (23%), Positives = 34/81 (41%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G+   +   + G P P V W+    +L  ++R+S         L +  ++  D+G Y  
Sbjct: 22356 AGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFL 22415

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N AG    +  V V+  P
Sbjct: 22416 TLENTAGVKTFSVTVVVIGRP 22436



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 4/93 (4%)

Query: 1432  RAGSTATSARLHVRETELLFLRR-LQDVRAEEGQDVCLEVE-TGRVGAAGAVRWVRGGQP 1489
             R   TA S +  +   E   +R+ ++DV  + G+   L  +  GR      ++W R G+ 
Sbjct: 24210 RPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGR--PLPDIKWYRFGKE 24267

Query: 1490  LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC 1522
             L    +  M+ DG  H L +      D+G Y C
Sbjct: 24268 LIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 24300



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 15/102 (14%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGG-------QQLAASERLSFPADGAEHGLLLTA 73
             V V +G    L  +V G P P V W K G        Q+   + ++F        L++  
Sbjct: 12311 VIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF--------LVIPN 12362

Query: 74    ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
             +   D+G Y     N AGE      V VL+ P    +L+ ++
Sbjct: 12363 STRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSD 12404



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 16/60 (26%), Positives = 30/60 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             +P   V W KDG  +  +  + +  +  +  L L +V  +DSG+Y    ++ S S + T+
Sbjct: 13017 KPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATI 13076



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 14/38 (36%), Positives = 22/38 (57%)

Query: 1114  WYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
             W K G ++  SD  Q+ +   +  LT+ +A  +DAGEY
Sbjct: 14108 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEY 14145



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 1/84 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP    +    K +  L W KP          Y +E Q+VG E WI+  +       
Sbjct: 14367 PPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 14426

Query: 576   EVPGDCVPSEGDYRFRICTVSGHG 599
             +     + ++  Y FRI  ++  G
Sbjct: 14427 QFVVPDLQTKEKYNFRISAINDAG 14450



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 7/97 (7%)

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGLEVEASDALQLGAEGPTRT 1137
             ++ PA + L   F      +L+ +V   G     V W+KD + ++ +  +   +      
Sbjct: 15840 VIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSL 15899

Query: 1138  LTLPHAQPEDAGEYVCETRH---EAI-TFNVILAEPP 1170
             LT+  A  ED G YV +  +   EAI T NVI+ + P
Sbjct: 15900 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15936



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 38/148 (25%), Positives = 56/148 (37%), Gaps = 23/148 (15%)

Query: 93    AYAAAAVTVL---EPPASDPELQPAER-PLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLT 148
             ++  AAV V    E   S  E++P ER  +P     +     +T      +  GA + L 
Sbjct: 23109 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVT------IRAGASLRLM 23162

Query: 149   CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRIL-AARLPDSGVY 207
                 G P P + W K G+ L              RA      S +L I+      D+G Y
Sbjct: 23163 VSVSGRPPPVITWSKQGIDL------------ASRAIIDTTESYSLLIVDKVNRYDAGKY 23210

Query: 208   VCHARNAHGHAQAGALLQVHQPPESPPA 235
                A N  G   A  L++V+  P   P+
Sbjct: 23211 TIEAENQSGKKSATVLVKVYDTPGPCPS 23238



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 32/110 (29%), Positives = 49/110 (44%), Gaps = 21/110 (19%)

Query: 424 VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDGE-----ELPVIC 472
           +T + P   +  + + VLEG  A     T EA + G       W RDG+      LP + 
Sbjct: 1   MTTQAPTFTQPLQSVVVLEGSTA-----TFEAHISGFPVPEVSWFRDGQVISTSTLPGVQ 55

Query: 473 QSSSGHMHALVLPGVTREDAG----EVTFSLGNSRTTTLLRVKCVKHSPP 518
            S S     L +P VT+ ++G    + T   G + +T  L VK  + +PP
Sbjct: 56  ISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK-AETAPP 104



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 47/196 (23%), Positives = 80/196 (40%), Gaps = 24/196 (12%)

Query: 343 FTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRL----LPCRKYEQIEEGTVRRL 397
           FT+PLQ V   E   A  E  +    +P  +WFR+ Q +    LP  +     +G  +  
Sbjct: 8   FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQI-SFSDGRAKLT 66

Query: 398 IIHRLKADDD--GIYLCEMRGRVRTVANVTVKG----PILKRLPRKLDVLEGENAVLLVE 451
           I    KA+     +      G+  + A + VK     P   +  + + V +G    L V 
Sbjct: 67  IPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVR 126

Query: 452 TLEAGVEG---RWSRDGEELPVICQ---SSSGHMHALVLPGVTREDAG----EVTFSLGN 501
               G+     ++ RDG E+        S  G +++L++     ED+G      T S+G 
Sbjct: 127 V--TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR 184

Query: 502 SRTTTLLRVKCVKHSP 517
           + +T  L V+  +  P
Sbjct: 185 ATSTAELLVQGEEEVP 200



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 22/104 (21%), Positives = 45/104 (43%), Gaps = 2/104 (1%)

Query: 1630 TIVRGPHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPRLRLQALGTRRLLQLR 1688
            TI    HD+ V EG+  +         +  V+W KDG  +  S RL ++       L++ 
Sbjct: 8083 TIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVP 8142

Query: 1689 RCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSARE 1732
            +   +DAG Y+  +   + G    ++  + + +    + + A +
Sbjct: 8143 KSVRADAGIYTITLEN-KLGSATASINVKVIGLPGPCKDIKASD 8185



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 26/112 (23%), Positives = 42/112 (37%), Gaps = 8/112 (7%)

Query: 232  SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR 291
            S    P +   P + P     +   V EG +      + G P P + W ++  P  PD +
Sbjct: 9798 SATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTW-FKAPPKKPDNK 9856

Query: 292  RLMYRDR-------DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
              +  D        D    L +   +  D GLY   A N+ G     ++L+V
Sbjct: 9857 EPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9908



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 2/88 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PG P    +    K  V L W+ P+    +P + Y +ER+  GS+DW +           
Sbjct: 11796 PGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHY 11855

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPHV 604
             +   CV ++  Y FR+ T +  G S  V
Sbjct: 11856 MVDRCVENQ-IYEFRVQTKNEGGESDWV 11882



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%)

Query: 153   GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHAR 212
             G P+PT+ W+K    L +    +          +    S  L I      DSG Y   AR
Sbjct: 14786 GRPKPTVTWKKGDQILKQTQRVNF---------ETTATSTILNINECVRSDSGPYPLTAR 14836

Query: 213   NAHGHAQAGALLQVHQPPESPPADP 237
             N  G       +QVH  P  PP  P
Sbjct: 14837 NIVGEVGDVITIQVHDIP-GPPTGP 14860



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 13/40 (32%), Positives = 20/40 (50%)

Query: 1659  VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
             VTW+K    L  + R+  +   T  +L +  C  SD+G Y
Sbjct: 14792 VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPY 14831



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 15/53 (28%), Positives = 29/53 (54%), Gaps = 1/53 (1%)

Query: 515   HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             + PP PP   E+    K+++++ W  P+    +  I Y +ER++   + WI+C
Sbjct: 15347 YGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKC 15399



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    +N+V L+W+ PE    +  + Y +E Q  GS+ W  C ++ K     
Sbjct: 15744 PLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATV-KVTEAT 15802

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             + G  +  E +Y FR+   +  G S
Sbjct: 15803 ITG-LIQGE-EYSFRVSAQNEKGIS 15825



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 29/107 (27%), Positives = 40/107 (37%), Gaps = 10/107 (9%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G  V L     G P PT+ W KD    D+   ++         +       ++ I  A  
Sbjct: 20582 GTSVKLRAGISGKPAPTIEWYKD----DKELQTNALVCVENTTD-----LASILIKDADR 20632

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
              +SG Y    RNA G A A   +Q+   P  PP  P E      E +
Sbjct: 20633 LNSGCYELKLRNAMGSASATIRVQILDKP-GPPGGPIEFKTVTAEKI 20678



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 18/77 (23%), Positives = 33/77 (42%), Gaps = 1/77 (1%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G   K R  + GKP P IEW+ + + L  +    +    D   +L +      + G Y  
Sbjct: 20582 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL-IKDADRLNSGCYEL 20640

Query: 320   AARNSAGQTLSAVQLHV 336
               RN+ G   + +++ +
Sbjct: 20641 KLRNAMGSASATIRVQI 20657



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/83 (28%), Positives = 29/83 (34%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +GA   L     G P P  VW K    L  S R       +   L +      DAG Y
Sbjct: 22064 VRAGASIRLFIAYQGRPTPTAVWSKPDSNL--SLRADIHTTDSFSTLTVENCNRNDAGKY 22121

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  N +G       V VL+ P
Sbjct: 22122 TLTVENNSGSKSITFTVKVLDTP 22144


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score =  461 bits (1185), Expect = e-129
 Identities = 389/1568 (24%), Positives = 676/1568 (43%), Gaps = 73/1568 (4%)

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
            K   V E + A+F C +    E  + W  +G  ++    +          +L +   Q  
Sbjct: 5121 KDVTVPERRQARFECVLTR--EANVIWS-KGPDIIKSSDKFDIIADGKKHILVINDSQFD 5177

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
            D G+Y        G+  SA +L V   RL+F  PL+D   +E   A   C++ + ++   
Sbjct: 5178 DEGVYTAEVE---GKKTSA-RLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVV 5233

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            WF+ D +L   R      EG   +L +  +  DD    + +++ +V+ +++ T +  +L+
Sbjct: 5234 WFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDD----ISQIKAQVKELSS-TAQLKVLE 5288

Query: 433  RLPRKLDVLEGENAVLLVE-TLEAGVEG----RWSRDGEEL---PVICQSSSGHMHALVL 484
              P     L  + AV   E TL+  V      +W +DGEE+   P     + G    L +
Sbjct: 5289 ADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKI 5348

Query: 485  PGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPA 544
                 +D GE     G  +T   + V+        P    E+F G      +    P+  
Sbjct: 5349 KKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVH 5408

Query: 545  PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
             +    ++L+ Q + +    +     K   + +    +   G+  F+    + + +S   
Sbjct: 5409 GQ----WKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQ----AANAKSAAN 5460

Query: 605  VFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
            +      L+     +  L DV+V++ ++A F  ++S   +   +L G          Q  
Sbjct: 5461 LKVKELPLI----FITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGT---------QEI 5507

Query: 665  PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
             G  R+ + + G +H +++ +   +D    + F       S  L I+   +  L+P   V
Sbjct: 5508 TGDDRFELIKDGTKHSMVIKSAAFEDEAKYM-FEAEDKHTSGKLIIEGIRLKFLTPLKDV 5566

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
              T    E  V T ELS  +    W+K+ Q++  +  + ++ +G+ H +   +  + D+ 
Sbjct: 5567 --TAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTS 5624

Query: 785  EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDG 844
            +      G+S+   +TV +   +     +      +  + V+L CE+ + DAPV+W+KDG
Sbjct: 5625 QIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDG 5682

Query: 845  QEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSG 904
            +E++ S   V++ +G  R L+L     SD G++ C  G +     + I D    +V P  
Sbjct: 5683 KEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLH 5742

Query: 905  KVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLED 964
             V V      R     E+        W   GE ++++P   +++E  +  LVL   +L+ 
Sbjct: 5743 SVEVMETETAR--FETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQ 5800

Query: 965  SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
            +G    +  +  +S  + V    + ++ P  +VT+ A   E     CELS ED PV WY 
Sbjct: 5801 TGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAG--ETATFDCELSYEDIPVEWYL 5858

Query: 1025 DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHP 1084
             G ++E S+ +V   +G    L L   + ED GE    A D      + V  PP     P
Sbjct: 5859 KGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKP 5918

Query: 1085 AARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQ 1144
                 D          L CEV+   ++V+W+K+G E+  S   ++ A+G  R L +    
Sbjct: 5919 LE---DQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCT 5975

Query: 1145 PEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV 1204
            PED   Y C+ +    + N+ +  P V+FL   T    L V   E     CELSR  A V
Sbjct: 5976 PEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTD---LQVREKEMARFECELSRENAKV 6032

Query: 1205 VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
             W  +G  +++G+  ++ ++G  R+L I          Y+C+   A  +  L+   + A 
Sbjct: 6033 KWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEA- 6091

Query: 1265 PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQ 1324
                V     A   V  T    ++LV  +S PG  V WYK  E +   GR ++   G ++
Sbjct: 6092 ----VFTKNLANIEVSETD--TIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKR 6145

Query: 1325 VLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS 1384
            +L +Q A   DAG Y C  P       V V E L  + +S+   L + EG+ A F C +S
Sbjct: 6146 ILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHE-LAAEFISKPQNLEILEGEKAEFVCSIS 6204

Query: 1385 PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHV 1444
                 V W R+   +  G + ++  +G  R+L ++   L D GT  +  G+   +A L V
Sbjct: 6205 KESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV 6264

Query: 1445 RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHI 1504
             E +L  +  L+D R +E Q+V    E    GA    +W R  + +   S+  + Q   +
Sbjct: 6265 IE-KLRIVVPLKDTRVKEQQEVVFNCEVNTEGAKA--KWFRNEEAIFDSSKYIILQKDLV 6321

Query: 1505 HRLFIHGVILADQGTYGCESHHDR-----TLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
            + L I    L DQ  Y     + R     + A L V    LR++ PL+D+   E  S TF
Sbjct: 6322 YTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTF 6381

Query: 1560 QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
              ++++  VT +W + G ++    +     D ++H L +   G  D G    TA   +  
Sbjct: 6382 WCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSV 6441

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
            A L++ E P   V    D  VTE D A F C+LS+  A+V W ++G  +    + + +  
Sbjct: 6442 AELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKD 6501

Query: 1680 GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
            G+   L ++ C   D   Y+C V   R    RL V E  V ++   + +    G    F 
Sbjct: 6502 GSIHRLIIKDCRLDDECEYACGV-EDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFL 6560

Query: 1740 CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA 1799
              +++ +   +W      +  G + ++  EGK H L + +++  D GE RF A   ++ A
Sbjct: 6561 AELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARA 6620

Query: 1800 LLEVEALP 1807
             LE+ A P
Sbjct: 6621 KLELAAAP 6628



 Score =  439 bits (1128), Expect = e-122
 Identities = 392/1575 (24%), Positives = 667/1575 (42%), Gaps = 85/1575 (5%)

Query: 327  QTLSAVQ---LHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPC 383
            Q L+A+    L VKE  L F  PL+DV   E   A  EC V        W +    +   
Sbjct: 5097 QALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC-VLTREANVIWSKGPDIIKSS 5155

Query: 384  RKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLD--VL 441
             K++ I +G    L+I+  + DD+G+Y  E+ G+ +T A + V G  LK +    D  V 
Sbjct: 5156 DKFDIIADGKKHILVINDSQFDDEGVYTAEVEGK-KTSARLFVTGIRLKFMSPLEDQTVK 5214

Query: 442  EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFS 498
            EGE A  + E     +   W ++  +L     +  SS G  H L +  VT +D  ++   
Sbjct: 5215 EGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 5274

Query: 499  LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-----IYRL 553
            +    +T  L+V  ++  P     L +     K+ + L  +  +  P   F     I   
Sbjct: 5275 VKELSSTAQLKV--LEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPS 5332

Query: 554  ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
             +  + ++   +   I+KA         +  +G+Y   +C         +V     A L+
Sbjct: 5333 PKYSIKADGLRRILKIKKAD--------LKDKGEY---VCDCGTDKTKANVTVE--ARLI 5379

Query: 614  PTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRI 672
               + + G+E   V+ GE A F ++LS   + G W L G+ L ++ P+ +         I
Sbjct: 5380 KVEKPLYGVE---VFVGETAHFEIELSEPDVHGQWKLKGQPLTAS-PDCE---------I 5426

Query: 673  EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
             + G +H LILH  +   +G  V F     + +A L ++E P+  ++P   V +     +
Sbjct: 5427 IEDGKKHILILHNCQLGMTGE-VSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKD 5483

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
                 CE+SR      W K  Q++   +   +  DG KH +++  A  +D  ++    E 
Sbjct: 5484 EAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAED 5543

Query: 793  VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDF 852
                  + ++   +  + P + V   A   E  +   E+  ++  V+W+K+ Q +  +  
Sbjct: 5544 KHTSGKLIIEGIRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRS 5601

Query: 853  VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVY-VAAV 911
            V +++EG    +        D  + +  A    +   +T+ +      Y +GK+     V
Sbjct: 5602 VSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDP---YFTGKLQDYTGV 5658

Query: 912  RLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCE 971
              + V+L CE+ +  A V+W KDG+E+  S   +++ +   R L+L      D G+Y C+
Sbjct: 5659 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 5718

Query: 972  IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEE 1031
               +  S  + + +  ++++ P   V ++    E      E+S +D    W   G  + +
Sbjct: 5719 CGTDKTSGKLDIEDREIKLVRPLHSVEVMET--ETARFETEISEDDIHANWKLKGEALLQ 5776

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDL 1091
            +    ++ +G    LVL   + +  G     A +  +   + V      ++ P     D+
Sbjct: 5777 TPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLK---DV 5833

Query: 1092 HFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
               A       CE++     V WY  G ++E SD +   +EG   TLTL   + EDAGE 
Sbjct: 5834 TVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEV 5893

Query: 1152 VCETRHEAITFNVILAEPPVQFLALETTP-SPLCVAPGEPVVLSCELSRAGAPVVWSHNG 1210
                +      N+ + EPPV+F    T P     V  G   VL CE+SR  A V W  NG
Sbjct: 5894 QLTAKDFKTHANLFVKEPPVEF----TKPLEDQTVEEGATAVLECEVSRENAKVKWFKNG 5949

Query: 1211 RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVV 1270
              + + +  E+ A+G  R L I    P     YTC +         S  + V  P V  +
Sbjct: 5950 TEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDF----KTSCNLNVVPPHVEFL 6005

Query: 1271 APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
             P     +VR       E    LS     V+W+KDG  +    +  +   GA ++L +  
Sbjct: 6006 RP-LTDLQVREKEMARFEC--ELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINK 6062

Query: 1331 ARSGDAGEYLCDA--PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA 1388
                D  EY C+    + S +  V  EE +  K    L  + V E D     CEVS P A
Sbjct: 6063 CLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTK---NLANIEVSETDTIKLVCEVSKPGA 6119

Query: 1389 DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETE 1448
            +V W +    +    + E+   G  RIL ++   L DAG    R  S+ T  ++ V E  
Sbjct: 6120 EVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELA 6179

Query: 1449 LLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLF 1508
              F+ + Q++   EG+         +   +  V+W R  + L    +  +  DG    L 
Sbjct: 6180 AEFISKPQNLEILEGEKAEFVCSISK--ESFPVQWKRDDKTLESGDKYDVIADGKKRVLV 6237

Query: 1509 IHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
            +    L D GTY       R  A L+V  + LR++ PL+D  + E     F  E++ EG 
Sbjct: 6238 VKDATLQDMGTYVVMVGAARAAAHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGA 6296

Query: 1569 TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC--VSFT---ADSLRCAARLI 1623
              +W R    ++   K  I      + L +    L D     VS T    ++++ AA LI
Sbjct: 6297 KAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLI 6356

Query: 1624 VREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRR 1683
            V E  + IV    D+E  E  + TF C++++    + W K+G  +    R+  +    + 
Sbjct: 6357 VEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKH 6416

Query: 1684 LLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVS 1743
            +L ++ CG  D G Y    G  ++    L + E     +  L   +  E D A F C +S
Sbjct: 6417 MLTIKDCGFPDEGEYIVTAGQDKS-VAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLS 6475

Query: 1744 EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEV 1803
              +   +W   GR ++ G + +  ++G  H L++ + R +D  E        +S A L V
Sbjct: 6476 REKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFV 6535

Query: 1804 EALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTH 1863
            E +P+++ R PP++     G   V    +++    V WLR    +  GDK++M S G  H
Sbjct: 6536 EEIPVEIIR-PPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIH 6594

Query: 1864 SLVIHDVRPEDQGTY 1878
             L I D++P DQG Y
Sbjct: 6595 RLQICDIKPRDQGEY 6609



 Score =  394 bits (1013), Expect = e-109
 Identities = 402/1699 (23%), Positives = 685/1699 (40%), Gaps = 129/1699 (7%)

Query: 228  QPPESPPADPDEAPAPVVEPLKCAPKTFWVNE------------GKHAKFRCYVMGKPEP 275
            +P       PDEAP      LK  P  F V E            G  A F C V   P  
Sbjct: 4720 RPGSGGEKPPDEAP--FTYQLKAVPLKF-VKEIKDIILTESEFVGSSAIFECLV--SPST 4774

Query: 276  EIE-WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             I  W  +G  +    +     D      L ++  Q  D G Y C  R    +  S  +L
Sbjct: 4775 AITTWMKDGSNIRESPKHRFIADGKDR-KLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKL 4833

Query: 335  HVKEPRLRFTRPLQD----VEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
             V+E  +RF + L++    V+G+      L C++ N      W R+D +++   K  +I 
Sbjct: 4834 VVEELPVRFVKTLEEEVTVVKGQP---LYLSCEL-NKERDVVW-RKDGKIV-VEKPGRIV 4887

Query: 391  EGTV---RRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-----GPILKRLPRKLDVLE 442
             G +   R L I+     D G Y   +        +  VK        L +  R   V  
Sbjct: 4888 PGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKP 4947

Query: 443  GENAVLLVETLEAGVEGRWSRDGEELPVICQSSS-----GHMHALVLPGVTREDAGEVTF 497
               A+   +  +     +W +  +E+P      +     G+   L +     ED  E   
Sbjct: 4948 KGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAV 5007

Query: 498  SLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLER-- 555
             +   R                    A++  G +   LL  KP E       IY  E   
Sbjct: 5008 EIEGKRYP------------------AKLTLGEREVELL--KPIEDVT----IYEKESAS 5043

Query: 556  --QEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
               E+   D    + ++       P   + +EG  RF         ++  V++  + + +
Sbjct: 5044 FDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQ-ALNAI 5102

Query: 614  PTARL---------VAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
             TA L            L+DV V +   A F   L+      W    + +KS++      
Sbjct: 5103 TTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTREANVIWSKGPDIIKSSD------ 5156

Query: 665  PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
                ++ I   G +H L+++  +  D G        G + SA L +    +  +SP +  
Sbjct: 5157 ----KFDIIADGKKHILVINDSQFDDEGVYTA-EVEGKKTSARLFVTGIRLKFMSPLE-- 5209

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
              T    E     CELS       W+K+  K+  S  +++  +G+ H+L + E  + D  
Sbjct: 5210 DQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDIS 5269

Query: 785  EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH---AITSECVMLACEVDREDAPVRWY 841
            + + + + +S+   + V +      DP   V +H   A+  + + L CEV + D PV+W+
Sbjct: 5270 QIKAQVKELSSTAQLKVLE-----ADPYFTVKLHDKTAVEKDEITLKCEVSK-DVPVKWF 5323

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            KDG+E+  S    ++ +G  R L +      D GE+ C  G +     VT   V + ++ 
Sbjct: 5324 KDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVT---VEARLIK 5380

Query: 902  PSGKVYVAAVRL-ERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960
                +Y   V + E      EL  P    +W   G+ +  SP   + ++     L+L   
Sbjct: 5381 VEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNC 5440

Query: 961  QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV 1020
            QL  +GE   +  +  ++  + V E P+  I P  +V +     +     CE+SRE    
Sbjct: 5441 QLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKDEAKFECEVSREPKTF 5498

Query: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
            RW K   E+   +   L +DG +  +V+ +A  ED  +++ +A D      + +     +
Sbjct: 5499 RWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLK 5558

Query: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140
             + P     D+            E++    +V+W+K+   +  + ++ +  EG T ++T 
Sbjct: 5559 FLTPLK---DVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITF 5615

Query: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 1200
                 +D  +   E    +    + + E    F               + V+L CE+S+A
Sbjct: 5616 KDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTG---KLQDYTGVEKDEVILQCEISKA 5672

Query: 1201 GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV 1260
             APV W  +G+ ++  +   + A+G +R+L ++ A  +  G YTC      G    S  +
Sbjct: 5673 DAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDC----GTDKTSGKL 5728

Query: 1261 QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA 1320
             + +  +++V P      V  T     E    +S       W   GE L      ++++ 
Sbjct: 5729 DIEDREIKLVRP-LHSVEVMETETARFE--TEISEDDIHANWKLKGEALLQTPDCEIKEE 5785

Query: 1321 GARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
            G    L +   R    G     A        + V +P ++ L+  L  +TV  G+ ATF 
Sbjct: 5786 GKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRV-KPRVIGLLRPLKDVTVTAGETATFD 5844

Query: 1381 CEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA 1440
            CE+S  D  V W   G  + P  +V     G    LTLR  +L DAG V L A    T A
Sbjct: 5845 CELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHA 5904

Query: 1441 RLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQ 1500
             L V+E  + F + L+D   EEG    LE E  R  A   V+W + G  +    +  +  
Sbjct: 5905 NLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA--KVKWFKNGTEILKSKKYEIVA 5962

Query: 1501 DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ 1560
            DG + +L IH     D  TY C++   +T   L+V P  +  LRPL D+ + E   A F+
Sbjct: 5963 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFE 6022

Query: 1561 LELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAA 1620
             ELS+E    +W + G ++  G K  I S G    LV+N   L D    S    + R + 
Sbjct: 6023 CELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSG 6082

Query: 1621 RLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALG 1680
             L V E      +   ++EV+E DT    CE+S+  A+V W K    +  + R  +   G
Sbjct: 6083 MLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEG 6142

Query: 1681 TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC 1740
             +R+L ++     DAG Y+C + ++R    ++ V E     +S+ +++   EG+ A F C
Sbjct: 6143 RKRILVIQNAHLEDAGNYNCRLPSSRTDG-KVKVHELAAEFISKPQNLEILEGEKAEFVC 6201

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA- 1799
            ++S+     +W+   + L  G +  +  +GKK +LV+ +   +D G      G A++ A 
Sbjct: 6202 SISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAH 6261

Query: 1800 LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSH 1859
            L  +E L + +   P ++  V   +  V    V+  G    W R    +    KY +   
Sbjct: 6262 LTVIEKLRIVV---PLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQK 6318

Query: 1860 GPTHSLVIHDVRPEDQGTY 1878
               ++L I D   +DQ  Y
Sbjct: 6319 DLVYTLRIRDAHLDDQANY 6337



 Score =  385 bits (988), Expect = e-106
 Identities = 420/1813 (23%), Positives = 709/1813 (39%), Gaps = 111/1813 (6%)

Query: 105  PASDPELQPAERP-------LPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
            P S  E  P E P       +P     E   + LT   S++V  G+  +  C        
Sbjct: 4721 PGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILT--ESEFV--GSSAIFECLVSPSTAI 4776

Query: 158  TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
            T  W KDG  + E          P       G    L I+  +L D+G Y C  R  +  
Sbjct: 4777 TT-WMKDGSNIRE---------SPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKE 4826

Query: 218  AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
              + A L V + P              V  +K   +   V +G+     C +    E ++
Sbjct: 4827 KTSTAKLVVEELP--------------VRFVKTLEEEVTVVKGQPLYLSCEL--NKERDV 4870

Query: 278  EWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             W  +G+ ++    R++         L +      D G Y     N+     S+    V+
Sbjct: 4871 VWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVE 4930

Query: 338  EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFR--EDQRLLPCRKYEQIEEGTVR 395
              R    +P++D   +  G A+  C +        WF+  ++    P  K E + +G   
Sbjct: 4931 VIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHL 4990

Query: 396  RLIIHRLKADDDGIYLCEMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVET 452
             L I     +D   Y  E+ G+ R  A +T+   +  +LK +   + + E E+A    E 
Sbjct: 4991 YLKIKNAMPEDIAEYAVEIEGK-RYPAKLTLGEREVELLKPI-EDVTIYEKESASFDAEI 5048

Query: 453  LEAGVEGRWSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLR 509
             EA + G+W   GE L   P     + G    L L  V  + AGEV +   N+ TT +L 
Sbjct: 5049 SEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILT 5108

Query: 510  VKCVK--HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCF 567
            VK ++   + P   +     +  +   +LT        E   I+      + S D     
Sbjct: 5109 VKEIELDFAVPLKDVTVPERRQARFECVLT-------REANVIWSKGPDIIKSSDKFDII 5161

Query: 568  SIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQV 627
            +  K   + +       EG Y      V G   S  +   G        + ++ LED  V
Sbjct: 5162 ADGKKHILVINDSQFDDEGVYT---AEVEGKKTSARLFVTGIR-----LKFMSPLEDQTV 5213

Query: 628  YDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
             +GE A F  +LS   +   WF N  +L ++              I  +G  H+L +  V
Sbjct: 5214 KEGETATFVCELSHEKMHVVWFKNDAKLHTSRT----------VLISSEGKTHKLEMKEV 5263

Query: 687  KHQDSGALVGFSCPGVQDSAALTIQES-PVHILSPQDRVSLTFTTSERVVLTCELSRVDF 745
               D   +       +  +A L + E+ P   +   D+   T    + + L CE+S+ D 
Sbjct: 5264 TLDDISQIKA-QVKELSSTAQLKVLEADPYFTVKLHDK---TAVEKDEITLKCEVSK-DV 5318

Query: 746  PATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPP 805
            P  W+KDG+++  S    +K DG +  L + +A ++D GE+ C          VTV+   
Sbjct: 5319 PVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARL 5378

Query: 806  VHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLV 865
            + +  P   V V     E      E+   D   +W   GQ +  S    +  +G    L+
Sbjct: 5379 IKVEKPLYGVEV--FVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILI 5436

Query: 866  LPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRP 925
            L   Q    GE    A +  +   + + ++    + P   V V     +     CE+ R 
Sbjct: 5437 LHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKV--FEKDEAKFECEVSRE 5494

Query: 926  WAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTE 985
                RW K  +E+       L K+ T   +V+ +   ED  +Y+ E +D+  S  + +  
Sbjct: 5495 PKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEG 5554

Query: 986  PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCR 1045
              ++ + P  +VT  A   E  V   ELS ++  V+W+K+   +  + ++ ++ +G    
Sbjct: 5555 IRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 5612

Query: 1046 LVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEV 1105
            +       +D  +   +A   S+   +TV    E   +   +  D        V L+CE+
Sbjct: 5613 ITFKDLSIDDTSQIRVEAMGMSSEAKLTVL---EGDPYFTGKLQDYTGVEKDEVILQCEI 5669

Query: 1106 APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVI 1165
            + A + V+W+KDG E++ S    + A+G  R L L  A   D G+Y C+   +  +  + 
Sbjct: 5670 SKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLD 5729

Query: 1166 LAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEG 1225
            + +  ++   L      + V   E      E+S       W   G  + +    E+  EG
Sbjct: 5730 IEDREIK---LVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEG 5786

Query: 1226 PRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGG 1285
                L +        G      G    A ++  +  +   P RV+        V  T G 
Sbjct: 5787 KIHSLVLHNCRLDQTG------GVDFQAANVKSSAHLRVKP-RVIGLLRPLKDVTVTAGE 5839

Query: 1286 DLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQ 1345
                   LS    PV WY  G++L    +V     G    L ++  +  DAGE    A  
Sbjct: 5840 TATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD 5899

Query: 1346 DSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQV 1405
                  + V+EP  V+    L   TV EG  A   CEVS  +A V W +NG  +    + 
Sbjct: 5900 FKTHANLFVKEPP-VEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKY 5958

Query: 1406 EMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQD 1465
            E+  +G  R L +  C   D  T T  A    TS  L+V    + FLR L D++  E + 
Sbjct: 5959 EIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEM 6018

Query: 1466 VCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESH 1525
               E E  R  A   V+W + G  +    +  +   G +  L I+  +L D+  Y CE  
Sbjct: 6019 ARFECELSRENAK--VKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR 6076

Query: 1526 HDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKC 1585
              RT   L+V   +    + L ++ +SE  +     E+S+ G    W +G  ++    + 
Sbjct: 6077 TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRY 6136

Query: 1586 HIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT 1645
             I ++G +  LV+    L D+G  +    S R   ++ V E+    +  P +LE+ EG+ 
Sbjct: 6137 EILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEK 6196

Query: 1646 ATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTA 1705
            A F C +S+    V W++D   L    +  + A G +R+L ++     D GTY   VG A
Sbjct: 6197 AEFVCSISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAA 6256

Query: 1706 RAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVR 1765
            RA    LTV E+ + ++  L+    +E     F C V+      +W      +   ++  
Sbjct: 6257 RAA-AHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYI 6314

Query: 1766 IRQEGKKHILVLSELRAEDAGE-----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTV 1820
            I Q+   + L + +   +D           +    +S A L VE   L++   P ++   
Sbjct: 6315 ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIV-EPLKDIET 6373

Query: 1821 LVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC 1880
            +  +       V+R    + W + G E+   ++   R     H L I D    D+G Y  
Sbjct: 6374 MEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIV 6433

Query: 1881 QAGQDSTHTRLLV 1893
             AGQD +   LL+
Sbjct: 6434 TAGQDKSVAELLI 6446



 Score =  380 bits (975), Expect = e-105
 Identities = 317/1277 (24%), Positives = 523/1277 (40%), Gaps = 41/1277 (3%)

Query: 622  LEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRL 681
            L D    + ++     ++S  +   WF +GEE+  +           +Y I+  GL+  L
Sbjct: 5297 LHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSP----------KYSIKADGLRRIL 5346

Query: 682  ILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELS 741
             +     +D G  V   C   +  A +T++   + +  P   V +     E      ELS
Sbjct: 5347 KIKKADLKDKGEYV-CDCGTDKTKANVTVEARLIKVEKPLYGVEVF--VGETAHFEIELS 5403

Query: 742  RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTV 801
              D    W   GQ +  S    +  DG+KH LIL   ++  +GE   +     +   + V
Sbjct: 5404 EPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKV 5463

Query: 802  QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPH 861
            ++ P+  + P   V V     +     CEV RE    RW K  QE+   D   L  +G  
Sbjct: 5464 KELPLIFITPLSDVKV--FEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTK 5521

Query: 862  RRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCE 921
              +V+ +    D  ++   A D+     + I  +    + P   V   A   E  V T E
Sbjct: 5522 HSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDV--TAKEKESAVFTVE 5579

Query: 922  LCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTV 981
            L      V+W K+ + +  + ++ +Q E     +    + ++D+ +   E    S+   +
Sbjct: 5580 LSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 5639

Query: 982  TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
            TV E          + T   V  + V+L CE+S+ DAPV+W+KDG E++ S+  V++ DG
Sbjct: 5640 TVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADG 5697

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             +  L+L  A   D G++ CD G D     + +     ++V P   S+++      R E 
Sbjct: 5698 KKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPL-HSVEVMETETARFET 5756

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
              E++       W   G  +  +   ++  EG   +L L + + +  G    +  +   +
Sbjct: 5757 --EISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSS 5814

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLEL 1221
             + +  +P V  + L      + V  GE     CELS    PV W   G+ ++  + +  
Sbjct: 5815 AH-LRVKPRV--IGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVP 5871

Query: 1222 HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRS 1281
             +EG    L ++      AG     +       +L     V EPPV    P   QT    
Sbjct: 5872 RSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----VKEPPVEFTKPLEDQT---V 5924

Query: 1282 TPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
              G    L   +S     V+W+K+G  +    + ++   G  + L +      D   Y C
Sbjct: 5925 EEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC 5984

Query: 1342 DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP 1401
            DA        ++V  P  V+ +  LT L V E + A F CE+S  +A V W ++GA +  
Sbjct: 5985 DAKDFKTSCNLNVVPPH-VEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKK 6043

Query: 1402 GPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAE 1461
            G + ++   G+ RIL +  C L D    +    +  TS  L V E E +F + L ++   
Sbjct: 6044 GKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVS 6103

Query: 1462 EGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYG 1521
            E   + L  E  + GA   V W +G + +    R  +  +G    L I    L D G Y 
Sbjct: 6104 ETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYN 6161

Query: 1522 CESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
            C     RT  ++ V       +   +++ I EG  A F   +S+E    +W R    L  
Sbjct: 6162 CRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLES 6221

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
            G K  + +DG +  LV+    L D G       + R AA L V E  + IV    D  V 
Sbjct: 6222 GDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK 6280

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA 1701
            E     F CE++   A   W ++  A+  S +  +        L++R     D   Y+ +
Sbjct: 6281 EQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVS 6340

Query: 1702 VGTARAGPVR----LTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRP 1757
            +   R   V+    L V E  + ++  L+ +   E    TF C V+ +  T +W   G  
Sbjct: 6341 LTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEE 6400

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            +    RV  R +  KH+L + +    D GE    AG  +S+A L +   P +   H   +
Sbjct: 6401 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHL-ED 6459

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
            +TV     AV    +SR   +V W R G E+  G KY+    G  H L+I D R +D+  
Sbjct: 6460 QTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECE 6519

Query: 1878 YCCQAGQDSTHTRLLVE 1894
            Y C      +  RL VE
Sbjct: 6520 YACGVEDRKSRARLFVE 6536



 Score =  371 bits (952), Expect = e-102
 Identities = 397/1661 (23%), Positives = 670/1661 (40%), Gaps = 102/1661 (6%)

Query: 276  EIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKD-RGLYVCAARNSAGQTLSAVQL 334
            E+ W++E + L+P   +         + L +     +D +G YVC A N +G+T ++ +L
Sbjct: 4396 EVNWYFENK-LVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKL 4454

Query: 335  H-VKEPRLRFTRPLQDVEGREHGIAVLECKV---PNSRIPTAWFREDQRLLPCRKYEQIE 390
              VK       R ++ +E     +A   C++   PN R    WF+  + +    K     
Sbjct: 4455 TVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRF--QWFKAGREIYESDKCSIRS 4512

Query: 391  EGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVANVTVKGP-----ILKRLPRKLDVLE 442
               +  L I R +  D G Y C+     G V   A +TV  P     + K LP +    E
Sbjct: 4513 SKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPERKP--E 4570

Query: 443  GENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLP-GVTREDAGEVTFSLGN 501
             +  V+L   L         R  EE P +       +    +P     +   EV      
Sbjct: 4571 PKEEVVLKSVLR-------KRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVT 4623

Query: 502  SRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE-TPFIYRLERQEVGS 560
             R   +     V    P  P+ A   K      + T KPP   PE TP    +    VG 
Sbjct: 4624 KRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGK 4683

Query: 561  EDWIQCFSIEKA---GAVEVPGDCVPSEGDYRFRICTVSGHGRSP--HVVFHGSAHLVPT 615
            +   +    E A   G ++      PS  +   R       G  P     F      VP 
Sbjct: 4684 KAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAVP- 4742

Query: 616  ARLVAGLEDV----QVYDGEDAVFS--LDLSTIIQGTWFLNGEELKSNEPEGQVEPGALR 669
             + V  ++D+      + G  A+F   +  ST I  TW  +G  ++ +           +
Sbjct: 4743 LKFVKEIKDIILTESEFVGSSAIFECLVSPSTAIT-TWMKDGSNIRESP----------K 4791

Query: 670  YRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD---SAALTIQESPVHILSPQDRVSL 726
            +R    G   +L +  V+  D+G        G ++   +A L ++E PV  +   +   +
Sbjct: 4792 HRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEE-EV 4850

Query: 727  TFTTSERVVLTCELSRVDFPATWYKDGQ-KVEESELLVVKMDGRKHRLILPEAKVQDSGE 785
            T    + + L+CEL++ +    W KDG+  VE+   +V  + G    L + +A   D+G 
Sbjct: 4851 TVVKGQPLYLSCELNK-ERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGT 4909

Query: 786  FECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECV------MLACEVDREDAPVR 839
            +    E  +     +     V +V+      V  I  + V      + AC++ ++   ++
Sbjct: 4910 YTVTVENANNLECSSC----VKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIK 4965

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+K   E+  E +D   +  +G H  L +    P D  E+      +     +T+ +   
Sbjct: 4966 WFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREV 5025

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             ++ P   V +     E      E+       +W   GE +  SP   ++ E   R L L
Sbjct: 5026 ELLKPIEDVTI--YEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTL 5083

Query: 958  PAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTL---IAVTLECVVLMCELS 1014
              V+L+ +GE L +  +   +  +TV E  +    P  +VT+        ECV     L+
Sbjct: 5084 HKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECV-----LT 5138

Query: 1015 REDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV 1074
            RE A V W K    ++ S+   +  DG +  LV+  +Q +D G +  +         + V
Sbjct: 5139 RE-ANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFV 5197

Query: 1075 TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGP 1134
            T    + + P     D            CE++     V W+K+  ++  S  + + +EG 
Sbjct: 5198 TGIRLKFMSPLE---DQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGK 5254

Query: 1135 TRTLTLPHAQPEDAGEYVCETRHEAIT--FNVILAEPPVQFLALETTPSPLCVAPGEPVV 1192
            T  L +     +D  +   + +  + T    V+ A+P       + T         + + 
Sbjct: 5255 THKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKT-----AVEKDEIT 5309

Query: 1193 LSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPG 1252
            L CE+S+   PV W  +G  +       + A+G RR+L I+ A     G Y C  G    
Sbjct: 5310 LKCEVSK-DVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGT--D 5366

Query: 1253 APSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQ 1312
                + TV+      R++  E     V    G      + LS P    +W   G+ L + 
Sbjct: 5367 KTKANVTVE-----ARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTAS 5421

Query: 1313 GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVH 1372
               ++ + G + +L +   + G  GE    A        + V+E  L+  ++ L+ + V 
Sbjct: 5422 PDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLI-FITPLSDVKVF 5480

Query: 1373 EGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
            E D+A F CEVS       WL+    +T   + E+ ++G+   + ++     D       
Sbjct: 5481 EKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFE 5540

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
            A    TS +L +    L FL  L+DV A+E +     VE         V+W +  Q L  
Sbjct: 5541 AEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDNI--RVKWFKNDQRLHT 5598

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTIS 1552
               +SM  +G  H +    + + D      E+    + A+L+V          L+D T  
Sbjct: 5599 TRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYTGV 5658

Query: 1553 EGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFT 1612
            E      Q E+S+     +W + G ++ P     I +DG +  L+L     +D G  +  
Sbjct: 5659 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 5718

Query: 1613 ADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSP 1672
              + + + +L + +  + +VR  H +EV E +TA FE E+S+      W+  G AL  +P
Sbjct: 5719 CGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTP 5778

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSARE 1732
               ++  G    L L  C     G         ++    L V+ R + +L  L+ V+   
Sbjct: 5779 DCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSS-AHLRVKPRVIGLLRPLKDVTVTA 5837

Query: 1733 GDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA 1792
            G+ ATF+C +S  +    W L G+ L P  +V  R EGK H L L +++ EDAGEV+  A
Sbjct: 5838 GETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTA 5897

Query: 1793 GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGD 1852
               ++ A L V+  P++  + P  ++TV  G  AVLE  VSR    V W + G E+    
Sbjct: 5898 KDFKTHANLFVKEPPVEFTK-PLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSK 5956

Query: 1853 KYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            KYE+ + G    LVIHD  PED  TY C A    T   L V
Sbjct: 5957 KYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV 5997



 Score =  349 bits (896), Expect = 1e-95
 Identities = 341/1251 (27%), Positives = 528/1251 (42%), Gaps = 98/1251 (7%)

Query: 701  GVQDSAALTIQESPVHILS---PQDRVSLTFTTSER---VVLTCELSRVDFPATWYKDGQ 754
            G ++ A + IQE+   ++    P     L  T SE    V LT  ++       WY + +
Sbjct: 4346 GTEEVATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSITNAK-EVNWYFENK 4404

Query: 755  KVEESELLVVKMDGRKHRLILPEAKVQD-SGEFECRT------EGVSAFFGVTVQDPPV- 806
             V   E      D   + L++ +   +D  GE+ C           SA   V  +  PV 
Sbjct: 4405 LVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVI 4464

Query: 807  -HIVDPREHVFVHAITSECVMLACEVDREDAP---VRWYKDGQEVEESDFVVLENEGPHR 862
               ++P E    H          CE+  + AP    +W+K G+E+ ESD   + +     
Sbjct: 4465 KRKIEPLEVALGHL-----AKFTCEI--QSAPNVRFQWFKAGREIYESDKCSIRSSKYIS 4517

Query: 863  RLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLER------- 915
             L +  TQ  D GE+ C A +E    + T T     +  P G+  V  +  ER       
Sbjct: 4518 SLEILRTQVVDCGEYTCKASNEYGSVSCTATLT---VTVPGGEKKVRKLLPERKPEPKEE 4574

Query: 916  VVLTCELCR------PWAEVRWTKDGE-------------EVVESPALLLQK----EDTV 952
            VVL   L +      P  E +  +  +             E VE P +  ++    E T 
Sbjct: 4575 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTK 4634

Query: 953  RRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
               + PA+ L  + E   + + E  +      EP    I     V ++    E      E
Sbjct: 4635 VPEIKPAIPLP-APEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEE 4693

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTV 1072
             ++   P++    G+  +    +  ER   R         P  GGE       D A FT 
Sbjct: 4694 AAKPKGPIK----GVPKKTPSPIEAERRKLR---------PGSGGE----KPPDEAPFTY 4736

Query: 1073 TVTAPPERIVHPAARSLDLHFGAPGRVEL-RCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
             + A P + V      +       G   +  C V+P+ +   W KDG  +  S   +  A
Sbjct: 4737 QLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIA 4796

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETR----HEAITFNVILAEPPVQFLALETTPSPLCVAP 1187
            +G  R L +   Q  DAGEY C  R     +  T  +++ E PV+F+  +T    + V  
Sbjct: 4797 DGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFV--KTLEEEVTVVK 4854

Query: 1188 GEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAE-GPRRVLCIQAAGPAHAGLYTCQ 1246
            G+P+ LSCEL++    VVW  +G+ V E  G  +    G  R L I  A    AG YT  
Sbjct: 4855 GQPLYLSCELNKE-RDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVT 4913

Query: 1247 SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
               A      S  V+V E     +        V+  P G       ++     ++W+K  
Sbjct: 4914 VENANNL-ECSSCVKVVEVIRDWLVKPIRDQHVK--PKGTAIFACDIAKDTPNIKWFKGY 4970

Query: 1307 ERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVS 1364
            + + ++   + ++ + G    L+++ A   D  EY  +         +++ E   V+L+ 
Sbjct: 4971 DEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGERE-VELLK 5029

Query: 1365 ELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             +  +T++E + A+F  E+S  D    W   G ++ P P  E+   G  R LTL   +L 
Sbjct: 5030 PIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLD 5089

Query: 1425 DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWV 1484
             AG V  +A +  T+A L V+E EL F   L+DV   E +    E    R      V W 
Sbjct: 5090 QAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTR---EANVIWS 5146

Query: 1485 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            +G   +    +  +  DG  H L I+     D+G Y  E    +T ARL V   +L+ + 
Sbjct: 5147 KGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIRLKFMS 5206

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLA 1604
            PLED T+ EG +ATF  ELS E +   W +   +L+      I S+G  H+L +  + L 
Sbjct: 5207 PLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLD 5266

Query: 1605 DSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKD 1664
            D   +      L   A+L V E         HD    E D  T +CE+S+ +  V W KD
Sbjct: 5267 DISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVP-VKWFKD 5325

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
            G  + PSP+  ++A G RR+L++++    D G Y C  GT +     +TV  R + V   
Sbjct: 5326 GEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKT-KANVTVEARLIKVEKP 5384

Query: 1725 LRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAED 1784
            L  V    G+ A FE  +SE +  G+W+L G+PL       I ++GKKHIL+L   +   
Sbjct: 5385 LYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGM 5444

Query: 1785 AGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLRE 1844
             GEV FQA  A+S A L+V+ LPL     P  +  V     A  E  VSR      WL+ 
Sbjct: 5445 TGEVSFQAANAKSAANLKVKELPLIFIT-PLSDVKVFEKDEAKFECEVSREPKTFRWLKG 5503

Query: 1845 GAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
              E+   D++E+   G  HS+VI     ED+  Y  +A    T  +L++EG
Sbjct: 5504 TQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEG 5554



 Score =  315 bits (807), Expect = 3e-85
 Identities = 253/996 (25%), Positives = 429/996 (43%), Gaps = 47/996 (4%)

Query: 917  VLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI---- 972
            +  C +    A   W KDG  + ESP      +   R+L +  VQL D+GEY C +    
Sbjct: 4765 IFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGN 4824

Query: 973  DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDG-LEVEE 1031
             +++++  + V E PVR +   +E   + V  + + L CEL++E   V W KDG + VE+
Sbjct: 4825 KEKTSTAKLVVEELPVRFVKTLEEEVTV-VKGQPLYLSCELNKE-RDVVWRKDGKIVVEK 4882

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGD----DSAFFTVTVTAPPERIVHPAAR 1087
               +V    G    L +  A   D G +     +    + +     V    + +V P   
Sbjct: 4883 PGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIR- 4941

Query: 1088 SLDLHFGAPGRVELRCEVAPAGSQVRWYK--DGLEVEASDALQLGAEGPTRTLTLPHAQP 1145
              D H    G     C++A     ++W+K  D +  E +D  ++  +G    L + +A P
Sbjct: 4942 --DQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMP 4999

Query: 1146 EDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV 1205
            ED  EY  E   +     + L E  V+ L        + +   E      E+S A  P  
Sbjct: 5000 EDIAEYAVEIEGKRYPAKLTLGEREVELL---KPIEDVTIYEKESASFDAEISEADIPGQ 5056

Query: 1206 WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG--LYTCQSGAAPGAPSL-SFTVQV 1262
            W   G  ++     E+ AEG +R L +       AG  LY   +       ++    +  
Sbjct: 5057 WKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDF 5116

Query: 1263 AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
            A P   V  PE  Q R       +  ++           W K  + + S  +  +   G 
Sbjct: 5117 AVPLKDVTVPERRQARFECVLTREANVI-----------WSKGPDIIKSSDKFDIIADGK 5165

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
            + +L +  ++  D G Y  +       +R+F+  +     +K +S L   TV EG+ ATF
Sbjct: 5166 KHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGETATF 5221

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATS 1439
             CE+S     V W +N A +     V ++  G +  L ++   L D   +  +    +++
Sbjct: 5222 VCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSST 5281

Query: 1440 ARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMA 1499
            A+L V E +  F  +L D  A E  ++ L+ E   V     V+W + G+ +    + S+ 
Sbjct: 5282 AQLKVLEADPYFTVKLHDKTAVEKDEITLKCE---VSKDVPVKWFKDGEEIVPSPKYSIK 5338

Query: 1500 QDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
             DG    L I    L D+G Y C+   D+T A ++V  R ++V +PL  V +  G +A F
Sbjct: 5339 ADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHF 5398

Query: 1560 QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
            ++ELS+  V G+W   G  L   P C I  DG +H L+L+   L  +G VSF A + + A
Sbjct: 5399 EIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA 5458

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
            A L V+E+P+  +    D++V E D A FECE+S+      W K    +T   R  L   
Sbjct: 5459 ANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKD 5518

Query: 1680 GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
            GT+  + ++     D   Y            +L +    +  L+ L+ V+A+E + A F 
Sbjct: 5519 GTKHSMVIKSAAFEDEAKYMFEAEDKHTSG-KLIIEGIRLKFLTPLKDVTAKEKESAVFT 5577

Query: 1740 CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA-GPAQSL 1798
              +S      +W    + L     V ++ EGK H +   +L  +D  ++R +A G +   
Sbjct: 5578 VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 5637

Query: 1799 ALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRS 1858
             L  +E  P    +   ++ T +     +L+  +S++   V W ++G E+ P     +++
Sbjct: 5638 KLTVLEGDPYFTGK--LQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKA 5695

Query: 1859 HGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             G    L++      D G Y C  G D T  +L +E
Sbjct: 5696 DGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIE 5731



 Score =  291 bits (745), Expect = 4e-78
 Identities = 315/1294 (24%), Positives = 508/1294 (39%), Gaps = 122/1294 (9%)

Query: 674  QKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA-LTIQESPVHILSPQDRVSLTFTTSE 732
            +KGLQ    L  + H+  GAL G +    +     + +   PV +L             E
Sbjct: 1764 RKGLQRIEELERMAHE--GALTGVTTDQKEKQKPDIVLYPEPVRVLE-----------GE 1810

Query: 733  RVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE 791
                 C ++    P   WY +GQ + +S+   V+ DG  H L + + K  D+GE +   E
Sbjct: 1811 TARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGEVKVTAE 1869

Query: 792  GVSAFFGVTVQDPPVHIV-------------DPREHVFVHAITSECVMLACEVDREDAPV 838
                  GV      + I              +PR    VH    E   L  EV + D PV
Sbjct: 1870 NPE---GVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVH----EPGKLQFEVQKVDRPV 1922

Query: 839  -----------------RWYKDGQEVEE--SDFVVLENEGPHRRLV---LPATQPSDG-G 875
                                K  +E EE  S F     EG +  +    L + +  +   
Sbjct: 1923 DTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYE 1982

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL------------- 922
            E      DE  ++T  +T+     +   GK+ +   + +++ L+  +             
Sbjct: 1983 ELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQT 2042

Query: 923  --------------CRPWAEVRWTKDGEEVVESPALLLQ-KEDTVRRLVLPAVQLEDSGE 967
                           +P  E  W K+G ++  S  +     ED V  LV+  V  EDS  
Sbjct: 2043 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSAS 2102

Query: 968  YLCE---IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM-CELSREDAPVRWY 1023
             + +   I  E++S    + +    I + ++   ++A   + +    CE S     V+WY
Sbjct: 2103 IMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWY 2162

Query: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVH 1083
            KDG+EV E +   +  D     L +      D  ++ C   +D    T         +V 
Sbjct: 2163 KDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVE 2222

Query: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHA 1143
                  D+        EL C V+P   + +WY + +E++++    + +    + LT+   
Sbjct: 2223 FVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDV 2282

Query: 1144 QPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP 1203
              ED GEY      +  T  + +   P+  L      S   V  G+ V L  ++S     
Sbjct: 2283 TKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQ---GLSDQKVCEGDIVQLEVKVSLESVE 2339

Query: 1204 VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVA 1263
             VW  +G+ VQ  + + +  +    +L I+      AG Y+    A      LS + +V+
Sbjct: 2340 GVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPAL----GLSTSGRVS 2395

Query: 1264 EPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG-GPVRWYKDGERLASQGRVQLEQAGA 1322
               V V+ P      V    G    L   +S P    V+WY + E++    RVQ    G 
Sbjct: 2396 VYSVDVITP---LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT 2452

Query: 1323 RQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE 1382
            +Q L +    + D G Y     +      +SVE+   +K++  L  LT  E  +  F  E
Sbjct: 2453 KQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK---IKIIRGLRDLTCTETQNVVFEVE 2509

Query: 1383 VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARL 1442
            +S    DV W      + P  + ++  +G    LT+      D G  T  AG   TS +L
Sbjct: 2510 LSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKL 2569

Query: 1443 HVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG 1502
             V    +   + L D    E Q+   E E     + G   W+R G+ LP  + +    DG
Sbjct: 2570 TVAGGAIS--KPLTDQTVAESQEAVFECEVANPDSKG--EWLRDGKHLPLTNNIRSESDG 2625

Query: 1503 HIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE 1562
            H  RL I    L D G Y  +    +T A+L V    +++ + L+++T++E   A F +E
Sbjct: 2626 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEA--VKIKKTLKNLTVTETQDAVFTVE 2683

Query: 1563 LSQEGVTG-EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAAR 1621
            L+   V G +W + GV L    K  I   G  + L +    + D     F    L  +AR
Sbjct: 2684 LTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASAR 2743

Query: 1622 LIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGT 1681
            L V  V   I++ P D+   E  T  FE  +S     V W      + PS + RL +   
Sbjct: 2744 LHVETVK--IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERK 2801

Query: 1682 RRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECT 1741
               L L+   PSDAG Y+  VG       +  +   T+ +   ++++   E   A+FEC 
Sbjct: 2802 VHKLMLQNISPSDAGEYTAVVGQLEC---KAKLFVETLHITKTMKNIEVPETKTASFECE 2858

Query: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALL 1801
            VS       W   G  +    + +I  +GK H L++     ED+ E  F  G  Q  A L
Sbjct: 2859 VSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATL 2918

Query: 1802 EVEALPL-QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860
             V  + +  M +    E+   +      EVTV+  G    WL+ G E+   DK +MR+  
Sbjct: 2919 TVTPIMITSMLKDINAEEKDTI----TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKK 2974

Query: 1861 PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             THSL I +V   D   Y   AG+ ++   L VE
Sbjct: 2975 LTHSLNIRNVHFGDAADYTFVAGKATSTATLYVE 3008



 Score =  283 bits (723), Expect = 1e-75
 Identities = 253/1072 (23%), Positives = 449/1072 (41%), Gaps = 36/1072 (3%)

Query: 831  VDREDAPVRWYKDGQEVEESDFVVLE-NEGPHRRLVLPATQPSDGGEFQC----VAGDEC 885
            V + D    WYK+G ++E SD +     E     LV+      D          +AG+  
Sbjct: 2056 VGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETS 2115

Query: 886  AYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945
            ++  + +            +  VA  +       CE   P+ +V+W KDG EV E     
Sbjct: 2116 SHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYR 2175

Query: 946  LQKEDTVRRLVLPAVQLEDSGEYLCE-IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTL 1004
            +  +  V  L +  +   D+ +Y C  ++DE+   T  +      + + ++   +     
Sbjct: 2176 MHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPES 2235

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
                L C +S E+   +WY + +E++ +    +     R  L +     ED GE+     
Sbjct: 2236 YSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVID 2295

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
                   + +   P  I+   +   D        V+L  +V+    +  W KDG EV+ S
Sbjct: 2296 GKKTTCKLKMKPRPIAILQGLS---DQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPS 2352

Query: 1125 DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            D + +  +  +  L +     EDAG Y        ++ +  ++   V  +   T    + 
Sbjct: 2353 DRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVI---TPLKDVN 2409

Query: 1185 VAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLY 1243
            V  G   VL C++S      V W  N   ++  + ++   +G ++ L I     +  G Y
Sbjct: 2410 VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2469

Query: 1244 TCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWY 1303
                G      +LS         V  +        +  T   ++   V LS  G  V W 
Sbjct: 2470 KLIVGRVETNCNLS---------VEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLV 1363
               + +    + ++E  G    L V      D G+Y   A ++     ++V    + K  
Sbjct: 2521 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISK-- 2578

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQL 1423
              LT  TV E  +A F CEV+ PD+   WLR+G  +     +    +G  R L +   +L
Sbjct: 2579 -PLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKL 2637

Query: 1424 GDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRW 1483
             D G  T +  ++ TSA+L V   ++   + L+++   E QD    VE       G V+W
Sbjct: 2638 DDIGEYTYKVATSKTSAKLKVEAVKIK--KTLKNLTVTETQDAVFTVELTHPNVKG-VQW 2694

Query: 1484 VRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVL 1543
            ++ G  L  + + +++  G I+ L I    + D+  YG         ARL V    ++++
Sbjct: 2695 IKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET--VKII 2752

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            +  +DVT  E  +  F++ +S + V  +W    V++ P  K  + S+   H+L+L  +  
Sbjct: 2753 KKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISP 2812

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
            +D+G  +     L C A+L V  + +T  +   ++EV E  TA+FECE+S       W K
Sbjct: 2813 SDAGEYTAVVGQLECKAKLFVETLHIT--KTMKNIEVPETKTASFECEVSHFNVPSMWLK 2870

Query: 1664 DGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLS 1723
            +G  +  S + ++   G    L +      D+  Y+   G  +   V  T+    + + S
Sbjct: 2871 NGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQ---VSATLTVTPIMITS 2927

Query: 1724 ELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
             L+ ++A E D  TFE TV+    + +W   G  ++   + ++R +   H L +  +   
Sbjct: 2928 MLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFG 2987

Query: 1784 DAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLR 1843
            DA +  F AG A S A L VEA  ++  +H  ++  VL  +RA+ E  VS     V W++
Sbjct: 2988 DAADYTFVAGKATSTATLYVEARHIEFRKHI-KDIKVLEKKRAMFECEVSEPDITVQWMK 3046

Query: 1844 EGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
            +  EL   D+ +++     H L+I   R  D G Y   AG + +  +L VEG
Sbjct: 3047 DDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEG 3098



 Score =  257 bits (657), Expect = 7e-68
 Identities = 273/1217 (22%), Positives = 467/1217 (38%), Gaps = 48/1217 (3%)

Query: 681  LILHAVKHQDSGALV--GFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVV-LT 737
            L++  V  +DS +++    +  G   S A  + ++   I   Q+   +     + +    
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFE 2149

Query: 738  CELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC---RTEGVS 794
            CE S       WYKDG +V E +   +  D + H L +      D+ ++ C     E V 
Sbjct: 2150 CETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVK 2209

Query: 795  AFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVV 854
                + V+   V  V   + + V    S    L C V  E+   +WY +  E++ +    
Sbjct: 2210 TTAKLIVEGAVVEFVKELQDIEVPESYSG--ELECIVSPENIEGKWYHNDVELKSNGKYT 2267

Query: 855  LENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLE 914
            + +    + L +      D GE+  V   +    T  +      I    G         +
Sbjct: 2268 ITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKT--TCKLKMKPRPIAILQGLSDQKVCEGD 2325

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V L  ++     E  W KDG+EV  S  + +  +     L++  +  ED+G Y   I  
Sbjct: 2326 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPA 2385

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESE 1033
               S +  V+   V +I P  +V +I  T    VL C++S  D   V+WY +  +++  +
Sbjct: 2386 LGLSTSGRVSVYSVDVITPLKDVNVIEGTK--AVLECKVSVPDVTSVKWYLNDEQIKPDD 2443

Query: 1034 ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSL-DLH 1092
             +     G + RLV+      D G +    G       ++V    E+I     R L DL 
Sbjct: 2444 RVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSV----EKI--KIIRGLRDLT 2497

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                  V    E++ +G  V W     E++ S   ++ A G    LT+ +   +D G+Y 
Sbjct: 2498 CTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYT 2557

Query: 1153 CETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRP 1212
                    +  + +A   +     + T     VA  +  V  CE++   +   W  +G+ 
Sbjct: 2558 FYAGENMTSGKLTVAGGAISKPLTDQT-----VAESQEAVFECEVANPDSKGEWLRDGKH 2612

Query: 1213 VQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
            +     +   ++G +R L I A      G YT +   +  +  L          V  V  
Sbjct: 2613 LPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLK---------VEAVKI 2663

Query: 1273 EAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGA 1331
            +     +  T   D    V L+ P    V+W K+G  L S  +  +   G    LR++  
Sbjct: 2664 KKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNC 2723

Query: 1332 RSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVT 1391
               D   Y     +      + VE   ++K   ++T L   E     F   VS     V 
Sbjct: 2724 AIVDESVYGFRLGRLGASARLHVETVKIIKKPKDVTAL---ENATVAFEVSVSHDTVPVK 2780

Query: 1392 WLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLF 1451
            W      + P  +  +        L L+     DAG  T   G     A+L V    +  
Sbjct: 2781 WFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHIT- 2839

Query: 1452 LRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHG 1511
             + ++++   E +    E E           W++ G  +    +  +   G +H+L I  
Sbjct: 2840 -KTMKNIEVPETKTASFECEVSHFNVPSM--WLKNGVEIEMSEKFKIVVQGKLHQLIIMN 2896

Query: 1512 VILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE 1571
                D   Y     +D+  A L+V P  + +   L+D+   E  + TF++ ++ EG++ +
Sbjct: 2897 TSTEDSAEYTFVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITFEVTVNYEGISYK 2954

Query: 1572 WARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTI 1631
            W + GV++    KC + +    H L +  +   D+   +F A      A L V    +  
Sbjct: 2955 WLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEF 3014

Query: 1632 VRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCG 1691
             +   D++V E   A FECE+S+    V W KD   L  + R+++Q       L +    
Sbjct: 3015 RKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTR 3074

Query: 1692 PSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRW 1751
             SDAG Y+   G       +L V  R V + S  + V   E   A  E  V+E +    W
Sbjct: 3075 MSDAGKYTVVAG-GNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHW 3133

Query: 1752 ELGGRPLRPGARVRIRQ--EGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
               G  +    + R +   E + H + +SE R  DAGE  F AG  +S   L V A    
Sbjct: 3134 YKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPP 3193

Query: 1810 MCRHPPREKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIH 1868
                  +  TV  G+ A     +S R    + W +E   L  G K +    G  ++L++ 
Sbjct: 3194 QVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLI 3253

Query: 1869 DVRPEDQGTYCCQAGQD 1885
            +  PED   Y C+A  D
Sbjct: 3254 EAFPEDAAVYTCEAKND 3270



 Score =  257 bits (657), Expect = 7e-68
 Identities = 274/1222 (22%), Positives = 495/1222 (40%), Gaps = 93/1222 (7%)

Query: 619  VAGLEDVQV---YDGE-DAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQ 674
            V  L+D++V   Y GE + + S +    I+G W+ N  ELKSN           +Y I  
Sbjct: 2224 VKELQDIEVPESYSGELECIVSPEN---IEGKWYHNDVELKSNG----------KYTITS 2270

Query: 675  KGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERV 734
            +  +  L +  V  +D G    F   G + +  L ++  P+ IL  Q          + V
Sbjct: 2271 RRGRQNLTVKDVTKEDQGEY-SFVIDGKKTTCKLKMKPRPIAIL--QGLSDQKVCEGDIV 2327

Query: 735  VLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVS 794
             L  ++S       W KDGQ+V+ S+ + + +D + H L++ +   +D+G +      + 
Sbjct: 2328 QLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALG 2387

Query: 795  AFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFV 853
                  V    V ++ P + V V  I     +L C+V   D   V+WY + ++++  D V
Sbjct: 2388 LSTSGRVSVYSVDVITPLKDVNV--IEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRV 2445

Query: 854  VLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRL 913
                +G  +RLV+  T  SD G ++ + G       +++  +        G   +     
Sbjct: 2446 QAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIK----IIRGLRDLTCTET 2501

Query: 914  ERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEID 973
            + VV   EL     +V W    +E+  S    ++    + +L +  +  +D G+Y     
Sbjct: 2502 QNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAG 2561

Query: 974  DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESE 1033
            +   S  +TV    +    P  + T +A + E V   CE++  D+   W +DG  +  + 
Sbjct: 2562 ENMTSGKLTVAGGAIS--KPLTDQT-VAESQEAV-FECEVANPDSKGEWLRDGKHLPLTN 2617

Query: 1034 ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHF 1093
             +  E DG + RL++ A + +D GE+            + V A     +    ++L +  
Sbjct: 2618 NIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVK---IKKTLKNLTVTE 2674

Query: 1094 --GAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
               A   VEL     P    V+W K+G+ +E+++   +  +G   +L + +    D   Y
Sbjct: 2675 TQDAVFTVEL---THPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 2731

Query: 1152 VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGR 1211
                     +     A   V+ + +   P  +       V     +S    PV W H   
Sbjct: 2732 GFRLGRLGAS-----ARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSV 2786

Query: 1212 PVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSF-TVQVAEPPVRVV 1270
             ++  +   L +E     L +Q   P+ AG YT   G       L   T+ + +    + 
Sbjct: 2787 EIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIE 2846

Query: 1271 APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
             PE        T   + E V H + P     W K+G  +    + ++   G    L +  
Sbjct: 2847 VPET------KTASFECE-VSHFNVPS---MWLKNGVEIEMSEKFKIVVQGKLHQLIIMN 2896

Query: 1331 ARSGDAGEY--LCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA 1388
              + D+ EY  +C   Q S    V+   P+++   S L  +   E D  TF   V+    
Sbjct: 2897 TSTEDSAEYTFVCGNDQVSATLTVT---PIMI--TSMLKDINAEEKDTITFEVTVNYEGI 2951

Query: 1389 DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETE 1448
               WL+NG  +    + +M     +  L +R    GDA   T  AG   ++A L+V    
Sbjct: 2952 SYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARH 3011

Query: 1449 LLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLF 1508
            + F + ++D++  E +    E E         V+W++  Q L    R+ + ++ ++HRL 
Sbjct: 3012 IEFRKHIKDIKVLEKKRAMFECEVSEPDIT--VQWMKDDQELQITDRIKIQKEKYVHRLL 3069

Query: 1509 IHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
            I    ++D G Y   +  + + A+L V  R +R+    ++V + E   A  + E++++ V
Sbjct: 3070 IPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDV 3129

Query: 1569 TGEWARGGVQL-YPGPKCHIHSDGHR-HRLVLNGLGLADSGCVSFTADSLRCAARLIVRE 1626
               W + G+++ +   + H +    R HR+ ++    +D+G  +F A   R +  L V  
Sbjct: 3130 DAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNA 3189

Query: 1627 V-PVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRL 1684
              P  +++    + V  G  A F   +S +    ++W K+   L+   + +    G    
Sbjct: 3190 PEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYT 3249

Query: 1685 LQLRRCGPSDAGTYSC------AVGTARAGPVRLTVRERTV------------AVLSELR 1726
            L L    P DA  Y+C       V T  A    L+V    V            A+++ L+
Sbjct: 3250 LLLIEAFPEDAAVYTCEAKNDYGVATTSAS---LSVEVPEVVSPDQEMPVYPPAIITPLQ 3306

Query: 1727 SVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG 1786
                 EG  A F+C VS  +    W    + ++P    R+ Q    + L ++E   ED G
Sbjct: 3307 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3366

Query: 1787 EVRFQA----GPAQSLALLEVE 1804
               F A    G   S A L +E
Sbjct: 3367 TYTFVASNAVGQVSSTANLSLE 3388



 Score =  257 bits (656), Expect = 9e-68
 Identities = 297/1331 (22%), Positives = 528/1331 (39%), Gaps = 109/1331 (8%)

Query: 612  LVPTARLVAGLEDVQ--VYDGEDAVFSLDLST---IIQGTWFLNGEELKSNEPEGQVEPG 666
            LV   +L+   +++Q  V   +D + + +  T    ++  W+ +G E+   +        
Sbjct: 2121 LVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGD-------- 2172

Query: 667  ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD-----SAALTIQESPVHILSPQ 721
              +YR+      H L +  +   D+     +SC  V+D     +A L ++ + V  +   
Sbjct: 2173 --KYRMHSDRKVHFLSILTIDTSDAE---DYSCVLVEDENVKTTAKLIVEGAVVEFVKEL 2227

Query: 722  DRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ 781
              + +  + S    L C +S  +    WY +  +++ +    +     +  L + +   +
Sbjct: 2228 QDIEVPESYSGE--LECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKE 2285

Query: 782  DSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
            D GE+    +G      + ++  P+ I+       V     + V L  +V  E     W 
Sbjct: 2286 DQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKV--CEGDIVQLEVKVSLESVEGVWM 2343

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            KDGQEV+ SD V +  +     L++      D G +          FT+    +S+    
Sbjct: 2344 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYS---------FTIPALGLST---- 2390

Query: 902  PSGKVYVAAVRL------------ERVVLTCELCRP-WAEVRWTKDGEEVVESPALLLQK 948
             SG+V V +V +             + VL C++  P    V+W  + E++     +    
Sbjct: 2391 -SGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV 2449

Query: 949  EDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV 1008
            + T +RLV+      D G Y   +     +  ++V +  ++II    ++T      + VV
Sbjct: 2450 KGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK--IKIIRGLRDLT--CTETQNVV 2505

Query: 1009 LMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA 1068
               ELS     V W     E++ S    +E  G   +L +     +D G++   AG++  
Sbjct: 2506 FEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMT 2565

Query: 1069 FFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQ 1128
               +TV      I  P     D            CEVA   S+  W +DG  +  ++ ++
Sbjct: 2566 SGKLTVAGGA--ISKPLT---DQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIR 2620

Query: 1129 LGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPG 1188
              ++G  R L +   + +D GEY  +     +  +   A+  V+ + ++ T   L V   
Sbjct: 2621 SESDGHKRRLIIAATKLDDIGEYTYK-----VATSKTSAKLKVEAVKIKKTLKNLTVTET 2675

Query: 1189 EPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
            +  V + EL+      V W  NG  ++  E   +  +G    L I+        +Y  + 
Sbjct: 2676 QDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRL 2735

Query: 1248 GAAPGAPSLSF-TVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
            G    +  L   TV++ + P  V A E A               V +S    PV+W+   
Sbjct: 2736 GRLGASARLHVETVKIIKKPKDVTALENATVAFE----------VSVSHDTVPVKWFHKS 2785

Query: 1307 ERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSEL 1366
              +    + +L        L +Q     DAGEY     Q      + VE   + K +  +
Sbjct: 2786 VEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNI 2845

Query: 1367 TPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDA 1426
                V E   A+F CEVS  +    WL+NG  +    + ++   G    L +      D+
Sbjct: 2846 E---VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDS 2902

Query: 1427 GTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRG 1486
               T   G+   SA L V  T ++    L+D+ AEE   +  EV     G +   +W++ 
Sbjct: 2903 AEYTFVCGNDQVSATLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGIS--YKWLKN 2958

Query: 1487 GQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPL 1546
            G  +    +  M      H L I  V   D   Y   +    + A L V  R +   + +
Sbjct: 2959 GVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHI 3018

Query: 1547 EDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADS 1606
            +D+ + E   A F+ E+S+  +T +W +   +L    +  I  + + HRL++    ++D+
Sbjct: 3019 KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3078

Query: 1607 GCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGN 1666
            G  +  A      A+L V    V I     +++V E   A  E E+++   D  W KDG 
Sbjct: 3079 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3138

Query: 1667 ALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
             +    + R + +  RR+  + +     SDAG Y+   G  R+             VL E
Sbjct: 3139 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQE 3198

Query: 1725 LRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
            L+ V+ + G  A F   +S   +    W    + L  G + +   +G+++ L+L E   E
Sbjct: 3199 LQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3258

Query: 1784 DAG----EVRFQAGPAQSLALLEVEALPL-----QMCRHPPREKTVLV------GRRAVL 1828
            DA     E +   G A + A L VE   +     +M  +PP   T L       G+ A  
Sbjct: 3259 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318

Query: 1829 EVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQ 1884
            +  VS +   V W  +  ++ P   + M     T+ L I +  PED+GTY   A    GQ
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3378

Query: 1885 DSTHTRLLVEG 1895
             S+   L +EG
Sbjct: 3379 VSSTANLSLEG 3389



 Score =  254 bits (650), Expect = 4e-67
 Identities = 329/1456 (22%), Positives = 574/1456 (39%), Gaps = 170/1456 (11%)

Query: 233  PPADPDEAPAPVVEPLKCAPKTF------WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            P   PD+     + P   APK F       V +G  A FR  V+GKP+PE EW+  G  +
Sbjct: 2016 PTFKPDKIE---LSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI 2072

Query: 287  LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRL-RFTR 345
                R   Y   D    L +    A+D    +  A N AG+T S   L V+  +L  FT+
Sbjct: 2073 ERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2132

Query: 346  PLQDVEGREHG-IAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKA 404
             LQDV  +E   +A  EC+     +   W+++   +    KY    +  V  L I  +  
Sbjct: 2133 ELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDT 2192

Query: 405  DDDGIYLCEM--RGRVRTVANVTVKGPILKRLP--RKLDVLEGENAVLLVETLEAGVEGR 460
             D   Y C +     V+T A + V+G +++ +   + ++V E  +  L        +EG+
Sbjct: 2193 SDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGK 2252

Query: 461  WSRDGEEL----PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
            W  +  EL         S  G  + L +  VT+ED GE +F +   +TT  L++K     
Sbjct: 2253 WYHNDVELKSNGKYTITSRRGRQN-LTVKDVTKEDQGEYSFVIDGKKTTCKLKMK----- 2306

Query: 517  PPGPPILAEMFKGHK----NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKA 572
             P P  + +     K    + V L  K    + E   ++  + QEV   D +     +++
Sbjct: 2307 -PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEG--VWMKDGQEVQPSDRVHIVIDKQS 2363

Query: 573  GAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGED 632
              + +        G+Y F I  + G   S  V  +    + P       L+DV V +G  
Sbjct: 2364 HMLLIEDMTKEDAGNYSFTIPAL-GLSTSGRVSVYSVDVITP-------LKDVNVIEGTK 2415

Query: 633  AVFSLDLST--IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQD 690
            AV    +S   +    W+LN E++K ++          R +   KG + RL+++     D
Sbjct: 2416 AVLECKVSVPDVTSVKWYLNDEQIKPDD----------RVQAIVKGTKQRLVINRTHASD 2465

Query: 691  SG---ALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA 747
             G    +VG     V+ +  L++++  + I   +D   LT T ++ VV   ELS      
Sbjct: 2466 EGPYKLIVG----RVETNCNLSVEKIKI-IRGLRD---LTCTETQNVVFEVELSHSGIDV 2517

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF-----ECRTEGVSAFFGVTVQ 802
             W    ++++ S    ++  G+ ++L +      D G++     E  T G     G  + 
Sbjct: 2518 LWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAIS 2577

Query: 803  DPPVH--IVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGP 860
             P     + + +E VF            CEV   D+   W +DG+ +  ++ +  E++G 
Sbjct: 2578 KPLTDQTVAESQEAVF-----------ECEVANPDSKGEWLRDGKHLPLTNNIRSESDGH 2626

Query: 861  HRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKV-----YVAAVRLER 915
             RRL++ AT+  D GE+          + V  +  S+ +   + K+      +     + 
Sbjct: 2627 KRRLIIAATKLDDIGEYT---------YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2677

Query: 916  VVLTCELCRPWAE-VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V T EL  P  + V+W K+G  +  +    +  + T+  L +    + D   Y   +  
Sbjct: 2678 AVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGR 2737

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEA 1034
              AS  + V    V+II    +VT  A+    V     +S +  PV+W+   +E++ S+ 
Sbjct: 2738 LGASARLHV--ETVKIIKKPKDVT--ALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDK 2793

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGD---DSAFF--TVTVTAPPERIVHPAARSL 1089
              L  +    +L+L    P D GE+    G     +  F  T+ +T   + I  P  ++ 
Sbjct: 2794 HRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT- 2852

Query: 1090 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
                         CEV+       W K+G+E+E S+  ++  +G    L + +   ED+ 
Sbjct: 2853 ---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSA 2903

Query: 1150 EY--VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWS 1207
            EY  VC     + T  V     P+   ++      +     + +     ++  G    W 
Sbjct: 2904 EYTFVCGNDQVSATLTV----TPIMITSM---LKDINAEEKDTITFEVTVNYEGISYKWL 2956

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE--- 1264
             NG  ++  +  ++  +     L I+      A  YT  +G A    +L    +  E   
Sbjct: 2957 KNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRK 3016

Query: 1265 --PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
                ++V+  + A                 +S P   V+W KD + L    R+++++   
Sbjct: 3017 HIKDIKVLEKKRAM------------FECEVSEPDITVQWMKDDQELQITDRIKIQKEKY 3064

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
               L +   R  DAG+Y   A      +++F+    E   V++ S    + V E   A  
Sbjct: 3065 VHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV----EGRDVRIRSIKKEVQVIEKQRAVV 3120

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRI--LTLRGCQLGDAGTVTLRAGSTA 1437
              EV+  D D  W ++G  +    Q         RI  + +   +  DAG  T  AG   
Sbjct: 3121 EFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNR 3180

Query: 1438 TSARLHVRETE-LLFLRRLQDVRAEEGQDV-CLEVETGRVGAAGAVRWVRGGQPLPHDSR 1495
            +S  L+V   E    L+ LQ V  + G+      V +GR      + W +  Q L    +
Sbjct: 3181 SSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGR--PQPKISWYKEEQLLSTGFK 3238

Query: 1496 LSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RTLARLSVRPRQL----------- 1540
                 DG  + L +      D   Y CE+ +D     T A LSV   ++           
Sbjct: 3239 CKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP 3298

Query: 1541 -RVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
              ++ PL+D   SEG  A FQ  +S   +   W     ++ P     +      ++L + 
Sbjct: 3299 PAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIA 3358

Query: 1600 GLGLADSGCVSFTADS 1615
                 D G  +F A +
Sbjct: 3359 EAYPEDEGTYTFVASN 3374



 Score =  238 bits (608), Expect = 3e-62
 Identities = 400/1896 (21%), Positives = 700/1896 (36%), Gaps = 265/1896 (13%)

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
            AP      +SQ V +G++     R  G P+P   W K+G+ ++       +   P   ED
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER--SDRIYWYWP---ED 2085

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
                 L +R + A   DS   +  A N  G   + A L V                 ++ 
Sbjct: 2086 NV-CELVIRDVTAE--DSASIMVKAINIAGETSSHAFLLVQAKQ-------------LIT 2129

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
              +         +   A F C    +P  +++W+ +G  +    +  M+ DR   F L +
Sbjct: 2130 FTQELQDVVAKEKDTMATFECET-SEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHF-LSI 2187

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            L     D   Y C          +A +L V+   + F + LQD+E  E     LEC V  
Sbjct: 2188 LTIDTSDAEDYSCVLVEDENVKTTA-KLIVEGAVVEFVKELQDIEVPESYSGELECIVSP 2246

Query: 367  SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
              I   W+  D  L    KY        + L +  +  +D G Y   + G+  T      
Sbjct: 2247 ENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCK---- 2302

Query: 427  KGPILKRLPRKLDVL---------EGENAVLLVETLEAGVEGRWSRDGEELP------VI 471
                LK  PR + +L         EG+   L V+     VEG W +DG+E+       ++
Sbjct: 2303 ----LKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIV 2358

Query: 472  CQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHK 531
                S   H L++  +T+EDAG  +F++     +T  RV         P     + +G K
Sbjct: 2359 IDKQS---HMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTK 2415

Query: 532  NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
              +      P+    T   + L  +++  +D +Q         + +       EG Y+  
Sbjct: 2416 AVLECKVSVPDV---TSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLI 2472

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
            +  V  +              V   +++ GL D+   + ++ VF ++LS         +G
Sbjct: 2473 VGRVETNCNLS----------VEKIKIIRGLRDLTCTETQNVVFEVELSH--------SG 2514

Query: 652  EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
             ++  N  + +++P + +Y+IE  G  ++L +  +   D G    ++   +  S  LT+ 
Sbjct: 2515 IDVLWNFKDKEIKPSS-KYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMT-SGKLTVA 2572

Query: 712  ESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKH 771
               +     +     T   S+  V  CE++  D    W +DG+ +  +  +  + DG K 
Sbjct: 2573 GGAIS----KPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKR 2628

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVH-------IVDPREHVFVHAITSEC 824
            RLI+   K+ D GE+  +         + V+   +        + + ++ VF   +T   
Sbjct: 2629 RLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPN 2688

Query: 825  VMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDE 884
            V            V+W K+G  +E ++   +  +G    L +            C   DE
Sbjct: 2689 VK----------GVQWIKNGVVLESNEKYAISVKGTIYSLRIK----------NCAIVDE 2728

Query: 885  CAY-FTVTITDVSSWIVYPSGKVY-----VAAVRLERVVLTCELCRPWAEVRWTKDGEEV 938
              Y F +     S+ +   + K+      V A+    V     +      V+W     E+
Sbjct: 2729 SVYGFRLGRLGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEI 2788

Query: 939  VESPALLLQKEDTVRRLVLPAVQLEDSGEYLC---EIDDESASF--TVTVTEPPVRIIYP 993
              S    L  E  V +L+L  +   D+GEY     +++ ++  F  T+ +T+    I  P
Sbjct: 2789 KPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVP 2848

Query: 994  RDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQP 1053
              +              CE+S  + P  W K+G+E+E SE   +   G   +L++     
Sbjct: 2849 ETKTASFE---------CEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTST 2899

Query: 1054 EDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVR 1113
            ED  E+    G+D    T+TVT      +   +   D++      +     V   G   +
Sbjct: 2900 EDSAEYTFVCGNDQVSATLTVTP-----IMITSMLKDINAEEKDTITFEVTVNYEGISYK 2954

Query: 1114 WYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQF 1173
            W K+G+E++++D  Q+  +  T +L + +    DA +Y         T  + +    ++F
Sbjct: 2955 WLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEF 3014

Query: 1174 LALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQ 1233
                     + V   +  +  CE+S     V W  + + +Q  + +++  E     L I 
Sbjct: 3015 ---RKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIP 3071

Query: 1234 AAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
            +   + AG YT  +G       L   V+  +  +R +  E    +V       +E  V+ 
Sbjct: 3072 STRMSDAGKYTVVAGGNVSTAKLF--VEGRDVRIRSIKKEV---QVIEKQRAVVEFEVNE 3126

Query: 1294 SGPGGPVRWYKDGERLASQGRVQLEQAGARQVLR--VQGARSGDAGEYLCDAPQDSRIFL 1351
                    WYKDG  +  Q + + +    R++ R  +   R  DAGEY   A ++     
Sbjct: 3127 DDVDA--HWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVT 3184

Query: 1352 VSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPGPQVEMAQN 1410
            + V  P   +++ EL P+TV  G  A F   +S  P   ++W +   +++ G + +   +
Sbjct: 3185 LYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHD 3244

Query: 1411 GSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELL------------FLRR 1454
            G    L L      DA   T  A    G   TSA L V   E++             +  
Sbjct: 3245 GQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITP 3304

Query: 1455 LQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVIL 1514
            LQD    EGQ    +      G    V W    + +       M Q    ++L I     
Sbjct: 3305 LQDTVTSEGQPARFQCRVS--GTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYP 3362

Query: 1515 ADQGTY--------------------GCESHHDRTL-----ARLSVRPRQLRV------L 1543
             D+GTY                    G     + T        LSV  ++  +      +
Sbjct: 3363 EDEGTYTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSVSFKKEPLGQKPSFI 3422

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTG---EWARGGVQLYPGPKCHIH---SDGHRHRLV 1597
            +PL  + +  G +  F   +S  G+     +W      + P      H   S G    L+
Sbjct: 3423 QPLSSLRVHNGETVRFHARVS--GIPKPEIQWFHNQQLILPTKDVVFHFEESTGMALMLI 3480

Query: 1598 LNGLG--LADSGC-VSFTADSLRCAARLIVR-EVPVTIVRGPHDLEVTEGDTATFECELS 1653
            ++          C  + +A    CAA L V  + P +I+    + E+ E +   F     
Sbjct: 3481 VDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHERIEQEI-EMEMKEFSSSFL 3539

Query: 1654 QALADVTWEKDGNALTPSPRLRLQALG-TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRL 1712
             A      E++G     S  L+L  +  T  LL       S++  Y     + + G   +
Sbjct: 3540 SA------EEEG---LHSAELQLSKINETLELL-------SESPVYPTKFDSEKEGTGPI 3583

Query: 1713 TVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGK 1771
             ++E + A +S         GD AT   TV  +     +W   G  L P A  +   +G 
Sbjct: 3584 FIKEVSNADISM--------GDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGD 3635

Query: 1772 KHILVLSELRAEDAGEVRFQAG------------------------PAQSLALLEVEALP 1807
             H L++   + ED GE    A                           +S     +E L 
Sbjct: 3636 DHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLG 3695

Query: 1808 LQMCRHPPREKTVL---VGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYEMRSHGPTH 1863
                 H  +E   +    G  A+ E TV       V W +E  +LC    Y +  H P  
Sbjct: 3696 GPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTI-IHNPNG 3754

Query: 1864 S--LVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
            S   +++D + ED G Y C+A    G+ +    LLV
Sbjct: 3755 SGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3790



 Score =  212 bits (539), Expect = 3e-54
 Identities = 217/957 (22%), Positives = 410/957 (42%), Gaps = 63/957 (6%)

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
            K   V  G+ A F C +  +  P +EW+ +G+ L P  + ++ R       L +   + +
Sbjct: 5831 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDK-VVPRSEGKVHTLTLRDVKLE 5888

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
            D G     A++      +   L VKEP + FT+PL+D    E   AVLEC+V        
Sbjct: 5889 DAGEVQLTAKDFK----THANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 5944

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            WF+    +L  +KYE + +G VR+L+IH    +D   Y C+ +   +T  N+ V  P ++
Sbjct: 5945 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD-FKTSCNLNVVPPHVE 6003

Query: 433  --RLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGV 487
              R    L V E E A    E      + +W +DG E+    +    S G +  LV+   
Sbjct: 6004 FLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKC 6063

Query: 488  TREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPET 547
              +D  E +  +  +RT+ +L V  ++        LA +     +T+ L  +  +P  E 
Sbjct: 6064 LLDDEAEYSCEVRTARTSGMLTV--LEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEV 6121

Query: 548  PFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFH 607
              I+    +E+      +  +  +   + +    +   G+Y  R+ +    G+   V  H
Sbjct: 6122 --IWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK---VKVH 6176

Query: 608  GSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPG 666
              A     A  ++  +++++ +GE A F   +S       W  + + L+S +        
Sbjct: 6177 ELA-----AEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGD-------- 6223

Query: 667  ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSL 726
              +Y +   G +  L++     QD G  V       + +A LT+ E    ++  +D    
Sbjct: 6224 --KYDVIADGKKRVLVVKDATLQDMGTYV-VMVGAARAAAHLTVIEKLRIVVPLKD---T 6277

Query: 727  TFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF 786
                 + VV  CE++     A W+++ + + +S   ++      + L + +A + D   +
Sbjct: 6278 RVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANY 6337

Query: 787  EC-----RTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
                   R E V +   + V++  + IV+P +   +  +  + V   C+V+R +  ++W 
Sbjct: 6338 NVSLTNHRGENVKSAANLIVEEEDLRIVEPLKD--IETMEKKSVTFWCKVNRLNVTLKWT 6395

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            K+G+EV   + V    +     L +      D GE+   AG + +   + I +  +  V 
Sbjct: 6396 KNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVE 6455

Query: 902  PSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQ 961
                  V     +  V +C+L R  A V+W ++G E+ E      +K+ ++ RL++   +
Sbjct: 6456 HLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCR 6513

Query: 962  LEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVR 1021
            L+D  EY C ++D  +   + V E PV II P  ++  +      VV + EL+++   V+
Sbjct: 6514 LDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDI--LEAPGADVVFLAELNKDKVEVQ 6571

Query: 1022 WYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERI 1081
            W ++ + V + +   +  +G   RL +   +P D GE+   A D  A   + + A P+  
Sbjct: 6572 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELAAAPK-- 6629

Query: 1082 VHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLP 1141
            +  A + L +  G P  + +  +  P  ++  W+K   E E      +       +  + 
Sbjct: 6630 IKTADQDLVVDVGKPLTMVVPYDAYPK-AEAEWFK---ENEPLSTKTIDTTAEQTSFRIL 6685

Query: 1142 HAQPEDAGEY--VCETRHEA----ITFNVILAEPPVQFLAL-ETTPSPLCVAPGEPV 1191
             A+  D G Y  V + +H      I   VI    PV+ L + ET    + +A  EP+
Sbjct: 6686 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPL 6742



 Score =  202 bits (514), Expect = 3e-51
 Identities = 155/558 (27%), Positives = 257/558 (46%), Gaps = 27/558 (4%)

Query: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNG 1411
            S+E P   K+   +   TV +G DA FR  V   PD +  W +NG  +    ++      
Sbjct: 2028 SMEAP---KIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPE 2084

Query: 1412 SSRI-LTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELL-FLRRLQDVRAEEGQD 1465
             +   L +R     D+ ++ ++A    G T++ A L V+  +L+ F + LQDV A+E   
Sbjct: 2085 DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDT 2144

Query: 1466 VC-LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC-- 1522
            +   E ET        V+W + G  +    +  M  D  +H L I  +  +D   Y C  
Sbjct: 2145 MATFECETSEPFVK--VKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVL 2202

Query: 1523 -ESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
             E  + +T A+L V    +  ++ L+D+ + E  S   +  +S E + G+W    V+L  
Sbjct: 2203 VEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKS 2262

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
              K  I S   R  L +  +   D G  SF  D  +   +L ++  P+ I++G  D +V 
Sbjct: 2263 NGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVC 2322

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC- 1700
            EGD    E ++S    +  W KDG  + PS R+ +       +L +      DAG YS  
Sbjct: 2323 EGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFT 2382

Query: 1701 --AVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRP 1757
              A+G + +G V +     +V V++ L+ V+  EG  A  EC VS  + T  +W L    
Sbjct: 2383 IPALGLSTSGRVSV----YSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQ 2438

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            ++P  RV+   +G K  LV++   A D G  +   G  ++   L VE + +       R+
Sbjct: 2439 IKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIKI---IRGLRD 2495

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
             T    +  V EV +S SG  V W  +  E+ P  KY++ +HG  + L + ++  +D+G 
Sbjct: 2496 LTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGK 2555

Query: 1878 YCCQAGQDSTHTRLLVEG 1895
            Y   AG++ T  +L V G
Sbjct: 2556 YTFYAGENMTSGKLTVAG 2573



 Score =  189 bits (480), Expect = 2e-47
 Identities = 271/1226 (22%), Positives = 469/1226 (38%), Gaps = 182/1226 (14%)

Query: 15   LRFPRPVRVVSGAEAE--LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
            L+F  P++ V+  E E  +  V L      V W K  Q+L  +  +S   +G  H +   
Sbjct: 5557 LKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFK 5616

Query: 73   AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                 D       A   + EA     +TVLE                      G P F  
Sbjct: 5617 DLSIDDTSQIRVEAMGMSSEA----KLTVLE----------------------GDPYFTG 5650

Query: 133  GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
              +    +   EV+L C       P + W KDG    E+  S +  ++     DG    L
Sbjct: 5651 KLQDYTGVEKDEVILQCEISKADAP-VKWFKDGK---EIKPSKNAVIKA----DGKKRML 5702

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             L+   A   D G Y C                      S   D ++    +V PL    
Sbjct: 5703 ILK--KALKSDIGQYTCDCGT---------------DKTSGKLDIEDREIKLVRPLHSVE 5745

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
                V E + A+F   +    E +I  +W+ +               G  +L+   C+ K
Sbjct: 5746 ----VMETETARFETEIS---EDDIHANWKLK---------------GEALLQTPDCEIK 5783

Query: 313  DRG------LYVCAARNSAG------QTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVL 360
            + G      L+ C    + G         S+  L VK   +   RPL+DV       A  
Sbjct: 5784 EEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATF 5843

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420
            +C++    IP  W+ + ++L P  K     EG V  L +  +K +D G      +   +T
Sbjct: 5844 DCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD-FKT 5902

Query: 421  VANVTVKGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SS 475
             AN+ VK P ++      D  V EG  AVL  E      + +W ++G E+    +    +
Sbjct: 5903 HANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVA 5962

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
             G +  LV+   T ED    T    + +T+  L V      PP    L  +         
Sbjct: 5963 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV-----VPPHVEFLRPLTD------- 6010

Query: 536  LTWKPPEPAPETPFIYRLERQEVGSEDWIQC-----FSIEKAGAVE--VPGDC-VPSEGD 587
            L  +  E A     + R   +    +D  +      + I   GAV   V   C +  E +
Sbjct: 6011 LQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAE 6070

Query: 588  YRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGT 646
            Y   + T    G            L   A     L +++V + +      ++S    +  
Sbjct: 6071 YSCEVRTARTSGM--------LTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVI 6122

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSC--PGVQD 704
            W+   EE+        +E G  RY I  +G +  L++     +D+G    ++C  P  + 
Sbjct: 6123 WYKGDEEI--------IETG--RYEILTEGRKRILVIQNAHLEDAG---NYNCRLPSSRT 6169

Query: 705  SAALTIQESPVHILS-PQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLV 763
               + + E     +S PQ   +L     E+    C +S+  FP  W +D + +E  +   
Sbjct: 6170 DGKVKVHELAAEFISKPQ---NLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGDKYD 6226

Query: 764  VKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSE 823
            V  DG+K  L++ +A +QD G +        A   +TV +  + IV P +   V     +
Sbjct: 6227 VIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK--EQQ 6283

Query: 824  CVMLACEVDREDAPVRWYKDGQEV-EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882
             V+  CEV+ E A  +W+++ + + + S +++L+ +  +   +  A              
Sbjct: 6284 EVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHL------------ 6331

Query: 883  DECAYFTVTITDVSSWIVYPSGKVYV--------------AAVRLERVVLTCELCRPWAE 928
            D+ A + V++T+     V  +  + V                +  + V   C++ R    
Sbjct: 6332 DDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVT 6391

Query: 929  VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPV 988
            ++WTK+GEEV     +  + +     L +      D GEY+     + +   + + E P 
Sbjct: 6392 LKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPT 6451

Query: 989  RIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVL 1048
              +   ++ T+     +  V  C+LSRE A V+WY++G E++E +    E+DG   RL++
Sbjct: 6452 EFVEHLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLII 6509

Query: 1049 PAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR-VELRCEVAP 1107
               + +D  E+ C   D  +   + V   P  I+ P    L+    APG  V    E+  
Sbjct: 6510 KDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILE----APGADVVFLAELNK 6565

Query: 1108 AGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILA 1167
               +V+W ++ + V   D  Q+ +EG    L +   +P D GEY    + +     + LA
Sbjct: 6566 DKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELA 6625

Query: 1168 EPPVQFLALETTPSPLCVAPGEPVVL 1193
              P     ++T    L V  G+P+ +
Sbjct: 6626 AAP----KIKTADQDLVVDVGKPLTM 6647



 Score =  185 bits (469), Expect = 4e-46
 Identities = 322/1474 (21%), Positives = 542/1474 (36%), Gaps = 185/1474 (12%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERL--SFPADGAEHGLLLTAALPTDAG 80
            V  G++A  +  V+G+P P   W K G ++  S+R+   +P D     L++      D+ 
Sbjct: 2043 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCE-LVIRDVTAEDSA 2101

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
              + +A N AGE  + A + V                           +  T      V 
Sbjct: 2102 SIMVKAINIAGETSSHAFLLVQAKQL----------------------ITFTQELQDVVA 2139

Query: 141  RGAEVVLT--CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            +  + + T  C     P   + W KDGM   EV +   + +   R          L IL 
Sbjct: 2140 KEKDTMATFECETSE-PFVKVKWYKDGM---EVHEGDKYRMHSDRKVH------FLSILT 2189

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN 258
                D+  Y C             L++      +     + A    V+ L    +   V 
Sbjct: 2190 IDTSDAEDYSC------------VLVEDENVKTTAKLIVEGAVVEFVKEL----QDIEVP 2233

Query: 259  EGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
            E    +  C V   PE  IE  W    + L    +     R G   L V     +D+G Y
Sbjct: 2234 ESYSGELECIV--SPE-NIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEY 2290

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
                        +  +L +K   +   + L D +  E  I  LE KV    +   W ++ 
Sbjct: 2291 SFVIDGKK----TTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDG 2346

Query: 378  QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL-------CEMRGRVRTVANVTVKGPI 430
            Q + P  +   + +     L+I  +  +D G Y            GRV +V +V V  P+
Sbjct: 2347 QEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRV-SVYSVDVITPL 2405

Query: 431  LKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPV---ICQSSSGHMHALVLPG 486
                 + ++V+EG  AVL  +     V   +W  + E++     +     G    LV+  
Sbjct: 2406 -----KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 2460

Query: 487  VTREDAGEVTFSLGNSRTTTLLRVKCVK--------HSPPGPPILAEMFKGHKN-TVLLT 537
                D G     +G   T   L V+ +K               ++ E+   H    VL  
Sbjct: 2461 THASDEGPYKLIVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520

Query: 538  WKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
            +K  E  P +   Y++E              I K   + +  D    EG Y F       
Sbjct: 2521 FKDKEIKPSSK--YKIEAHG----------KIYKLTVLNMMKD---DEGKYTF---YAGE 2562

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLST-IIQGTWFLNGEELKS 656
            +  S  +   G A   P       L D  V + ++AVF  +++    +G W  +G+ L  
Sbjct: 2563 NMTSGKLTVAGGAISKP-------LTDQTVAESQEAVFECEVANPDSKGEWLRDGKHL-- 2613

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVH 716
                    P     R E  G + RLI+ A K  D G    +     + SA L ++   + 
Sbjct: 2614 --------PLTNNIRSESDGHKRRLIIAATKLDDIGEYT-YKVATSKTSAKLKVEAVKI- 2663

Query: 717  ILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLIL 775
                +   +LT T ++  V T EL+  +     W K+G  +E +E   + + G  + L +
Sbjct: 2664 ---KKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI 2720

Query: 776  PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
                + D   +  R   + A   + V+   + I  P++   V A+ +  V     V  + 
Sbjct: 2721 KNCAIVDESVYGFRLGRLGASARLHVETVKI-IKKPKD---VTALENATVAFEVSVSHDT 2776

Query: 836  APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-ECA----YFTV 890
             PV+W+    E++ SD   L +E    +L+L    PSD GE+  V G  EC       T+
Sbjct: 2777 VPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL 2836

Query: 891  TITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKED 950
             IT     I  P  K              CE+        W K+G E+  S    +  + 
Sbjct: 2837 HITKTMKNIEVPETKT---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQG 2887

Query: 951  TVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM 1010
             + +L++     EDS EY     ++  S T+TVT  P+ I     ++   A   + +   
Sbjct: 2888 KLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVT--PIMITSMLKDIN--AEEKDTITFE 2943

Query: 1011 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 1070
              ++ E    +W K+G+E++ ++   +        L +      D  ++   AG  ++  
Sbjct: 2944 VTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTA 3003

Query: 1071 TVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
            T+ V A   R +       D+      R    CEV+     V+W KD  E++ +D +++ 
Sbjct: 3004 TLYVEA---RHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQ 3060

Query: 1131 AEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEP 1190
             E     L +P  +  DAG+Y         T  + +    V+  +++     + V   + 
Sbjct: 3061 KEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIK---KEVQVIEKQR 3117

Query: 1191 VVLSCELSRAGAPVVWSHNGRPV--QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
             V+  E++       W  +G  +  Q  E  +   E     + I     + AG YT  +G
Sbjct: 3118 AVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAG 3177

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGE 1307
                  S++  V   EPP   V  E     V+S  G        +SG P   + WYK+ +
Sbjct: 3178 R--NRSSVTLYVNAPEPP--QVLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKEEQ 3231

Query: 1308 RLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL----VSVEEPLLVK-- 1361
             L++  + +    G    L +  A   DA  Y C+A  D  +      +SVE P +V   
Sbjct: 3232 LLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPD 3291

Query: 1362 ---------LVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGS 1412
                     +++ L      EG  A F+C VS  D  V+W      + P     M Q   
Sbjct: 3292 QEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFED 3351

Query: 1413 SRILTLRGCQLGDAGTVTLRA----GSTATSARL 1442
            +  L +      D GT T  A    G  +++A L
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3385



 Score =  116 bits (290), Expect = 2e-25
 Identities = 219/1074 (20%), Positives = 389/1074 (36%), Gaps = 173/1074 (16%)

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+ DGQ++  + +  VV++ +G    +++PAT PSD GE+  VA +     ++++     
Sbjct: 1444 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPAT-PSDSGEWTVVAQNRAGRSSISVILTVE 1502

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             + +    ++V  ++   +    E  R   +VR T +    +    + L+  D +     
Sbjct: 1503 AVEHQVKPMFVEKLKNVNIK---EGSRLEMKVRATGNPNPDI----VWLKNSDIIVPHKY 1555

Query: 958  PAVQLEDS-GEYLCEID----DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
            P +++E + GE   +ID     +SA +T T      R      + T   V +E       
Sbjct: 1556 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGR------DTTRCKVNVEV------ 1603

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCR-LVLPAAQP---------EDGGEFVCD 1062
                        +  E E    L++ R   R + +  P  +P          + G+    
Sbjct: 1604 ------------EFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDK 1651

Query: 1063 AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGL 1119
                  FF   +T+   +   PA      HF         C + P G     V W  DG 
Sbjct: 1652 EKQQKPFFKKKLTSLRLKRFGPA------HF--------ECRLTPIGDPTMVVEWLHDGK 1697

Query: 1120 EVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETT 1179
             +EA++ L++  E    +L    A   D+G   C   ++  T               + T
Sbjct: 1698 PLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGT---------------DHT 1742

Query: 1180 PSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAH 1239
             + L V   + +V   +L            GR     +GL+   E  R          AH
Sbjct: 1743 SATLIVKDEKSLVEESQLP----------EGR-----KGLQRIEELERM---------AH 1778

Query: 1240 AGLYTCQSGAAPGAPSLSFTVQVAEP-PVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGG 1298
             G  T   G             V  P PVRV+  E A+ R R T             P  
Sbjct: 1779 EGALT---GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVT-----------GYPQP 1824

Query: 1299 PVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPL 1358
             V WY +G+ +    R ++   G    L +   +S D GE             V+ E P 
Sbjct: 1825 KVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGE-----------VKVTAENP- 1871

Query: 1359 LVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL 1418
               ++     L + + +D       +P               P P+  + + G  +    
Sbjct: 1872 -EGVIEHKVKLEIQQREDFRSVLRRAP--------------EPRPEFHVHEPGKLQF--- 1913

Query: 1419 RGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAA 1478
                  +   V     +T T   + ++  E +   ++ +   E         E G   A 
Sbjct: 1914 ------EVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 1967

Query: 1479 GAVRWVRGGQPLPHDSRLSMAQDGHIH----RLFIHGVILADQGTYGCESHHDRTLARLS 1534
             AV      +   ++  L   +D  +H            LA++G     +     +  LS
Sbjct: 1968 TAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKI-ELS 2026

Query: 1535 VRPRQLRVLRPLEDVTISEGGSATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIH-SDGH 1592
                  ++   ++  T+ +G  A F++  + +     EW + GV++    + + +  + +
Sbjct: 2027 PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDN 2086

Query: 1593 RHRLVLNGLGLADSG-----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT-A 1646
               LV+  +   DS       ++   ++   A  L+  +  +T  +   D+   E DT A
Sbjct: 2087 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMA 2146

Query: 1647 TFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR 1706
            TFECE S+    V W KDG  +    + R+ +      L +     SDA  YSC +    
Sbjct: 2147 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE 2206

Query: 1707 --AGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARV 1764
                  +L V    V  + EL+ +   E      EC VS     G+W      L+   + 
Sbjct: 2207 NVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKY 2266

Query: 1765 RIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGR 1824
             I     +  L + ++  ED GE  F     ++   L+++  P+ + +    +K V  G 
Sbjct: 2267 TITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQK-VCEGD 2325

Query: 1825 RAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               LEV VS       W+++G E+ P D+  +     +H L+I D+  ED G Y
Sbjct: 2326 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNY 2379



 Score =  105 bits (263), Expect = 3e-22
 Identities = 93/343 (27%), Positives = 138/343 (40%), Gaps = 41/343 (11%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  L+  +PV V SG  A    V+ G P P + W K  Q L+   +  F  DG E+ LL
Sbjct: 3192 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3251

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            L  A P DA VY C A+N  G A  +A+++V  P    P+ +    P          P  
Sbjct: 3252 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP----------PAI 3301

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +T  +      G      CR  G      ++ KD     ++  S  F +   + ED    
Sbjct: 3302 ITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKD----KKIKPSRFFRMT--QFED---- 3351

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVH----------------QPPESPP 234
            +  L I  A   D G Y   A NA G   + A L +                     S  
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSVSFK 3411

Query: 235  ADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLM 294
             +P       ++PL     +  V+ G+  +F   V G P+PEI+W    + +LP +  + 
Sbjct: 3412 KEPLGQKPSFIQPL----SSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVF 3467

Query: 295  YRDRDGGFVLKVLY-CQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            + +   G  L ++    ++  G Y C A NSAG+   A  L V
Sbjct: 3468 HFEESTGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTV 3510



 Score =  100 bits (249), Expect = 1e-20
 Identities = 121/498 (24%), Positives = 198/498 (39%), Gaps = 82/498 (16%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F+  P+ + ++ G +AE  C +  E  PV  W++  + L + ++    ADG +  L++  
Sbjct: 6182 FISKPQNLEILEGEKAEFVCSISKESFPVQ-WKRDDKTLESGDKYDVIADGKKRVLVVKD 6240

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEP-----PASDPELQPAERPLPSPGSGEGAP 128
            A   D G YV       G A AAA +TV+E      P  D  ++  +             
Sbjct: 6241 ATLQDMGTYVV----MVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQ------------- 6283

Query: 129  VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                           EVV  C          ++  +    + ++DSS + +         
Sbjct: 6284 ---------------EVVFNCEVNTEGAKAKWFRNE----EAIFDSSKYIILQ------K 6318

Query: 189  GASLALRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
                 LRI  A L D   Y     N  G + ++ A L V           +E    +VEP
Sbjct: 6319 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIV-----------EEEDLRIVEP 6367

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
            L    K     E K   F C V  +    ++W   G   +P   R+ YR      +L + 
Sbjct: 6368 L----KDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE-VPFDNRVSYRVDKYKHMLTIK 6421

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS 367
             C   D G Y+     +AGQ  S  +L + E    F   L+D    E   AV  C++   
Sbjct: 6422 DCGFPDEGEYIV----TAGQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSRE 6477

Query: 368  RIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK 427
            +    W+R  + +   +KY+  ++G++ RLII   + DD+  Y C +  R ++ A + V+
Sbjct: 6478 KANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDR-KSRARLFVE 6536

Query: 428  GPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQS------SSGHM 479
               ++ +    D+LE  G + V L E  +  VE +W R+     V+ Q       S G +
Sbjct: 6537 EIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNN---MVVVQGDKHQMMSEGKI 6593

Query: 480  HALVLPGVTREDAGEVTF 497
            H L +  +   D GE  F
Sbjct: 6594 HRLQICDIKPRDQGEYRF 6611



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 96/385 (24%), Positives = 144/385 (37%), Gaps = 67/385 (17%)

Query: 9    GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
            G  P F++    +RV +G        V G P P + W    Q +  ++ + F  + +   
Sbjct: 3416 GQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEESTGM 3475

Query: 69   --LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP--------------------- 105
              +L+  A    AG Y C+A N+AGEA  AA +TV                         
Sbjct: 3476 ALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHERIEQEIEMEMKEFS 3535

Query: 106  -----ASDPELQPAERPLP--------------------SPGSGEGAPVFLTGPRSQWVL 140
                 A +  L  AE  L                     S   G G P+F+    +  + 
Sbjct: 3536 SSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTG-PIFIKEVSNADIS 3594

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
             G    L+    G+P+P + W  +G+ L    D            DG   SL   IL  +
Sbjct: 3595 MGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVF-------DGDDHSLI--ILFTK 3645

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPES-PPADPDEAPAPVVEPL--KCAP----- 252
            L D G Y C A N +G     A L+++   E     + + A A  +E L   C P     
Sbjct: 3646 LEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKE 3705

Query: 253  -KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
             K     +G  A F   V+G+P P + W  E + L       +  + +G     V   Q 
Sbjct: 3706 LKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVNDPQR 3765

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHV 336
            +D GLY+C A N  G++  A +L V
Sbjct: 3766 EDSGLYICKAENMLGESTCAAELLV 3790



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 95/431 (22%), Positives = 169/431 (39%), Gaps = 71/431 (16%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F +  + ++V+    A  +C V  EP   V W K  Q+L  ++R+    +   H LL+ +
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPS 3072

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
               +DAG Y       AG   + A + V                       EG  V +  
Sbjct: 3073 TRMSDAGKYTV----VAGGNVSTAKLFV-----------------------EGRDVRIRS 3105

Query: 134  PRSQ-WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
             + +  V+     V+        +   +W KDG+ ++      H  +   R         
Sbjct: 3106 IKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYVVERRIH------- 3157

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             + I   R  D+G Y   A    G  ++   L V+ P           P  V++ L+  P
Sbjct: 3158 RMFISETRQSDAGEYTFVA----GRNRSSVTLYVNAP----------EPPQVLQELQ--P 3201

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
             T  V  GK A+F   + G+P+P+I W+ E   LL    +  +      + L ++    +
Sbjct: 3202 VT--VQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3258

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRL------------RFTRPLQDVEGREHGIAVL 360
            D  +Y C A+N  G   ++  L V+ P +                PLQD    E   A  
Sbjct: 3259 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY---LCEMRGR 417
            +C+V  + +  +W+ +D+++ P R +   +     +L I     +D+G Y        G+
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3378

Query: 418  VRTVANVTVKG 428
            V + AN++++G
Sbjct: 3379 VSSTANLSLEG 3389



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 191/1020 (18%), Positives = 346/1020 (33%), Gaps = 168/1020 (16%)

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVT 891
             A V+WY +G E++ES  +   N      L +      D G ++ V     G+   Y T+ 
Sbjct: 26031 AEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLD 26090

Query: 892   ITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDT 951
             +T    +  Y S +      R     LT      +A   + K  E    S    ++ + T
Sbjct: 26091 VTG-GDYTTYASQRRDEEVPRSVFPELT--RTEAYAVSSFKKTSEMEASSSVREVKSQMT 26147

Query: 952   VRRLVLPAVQLEDSGEYLC------EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLE 1005
               R  L + +   S E          ++++S +  +  T     +  PR   ++     E
Sbjct: 26148 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR---SMTVYEGE 26204

Query: 1006  CVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--- 1061
                  C+   E  P V W + G  +  S    +     +    + + Q  D G +     
Sbjct: 26205 SARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVE 26264

Query: 1062  -DAGDDSAFFTVT----------VTAPPE------RIVHPAA------------------ 1086
                G   A FT+T          VT+PP       R+  P A                  
Sbjct: 26265 NSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAV 26324

Query: 1087  -----------RSLDLHFGAPGRV-------------ELRCEVAPA---GSQVRWYKDGL 1119
                        +   L   AP ++             +L C V  +     +V WYKDG 
Sbjct: 26325 SPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGK 26384

Query: 1120  EVEASDALQL--GAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLAL- 1176
             +++ +   Q    A+G T  L + +    D GEYVCE   E  T    L      F ++ 
Sbjct: 26385 KLKENGHFQFHYSADG-TYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH 26443

Query: 1177  -----------------ETT---------PSPLCVAP-----------GEPVVLSCELSR 1199
                              E+T         P P+   P               V    +  
Sbjct: 26444 EKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKA 26503

Query: 1200  AGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSL 1256
              G P    +W+ +G+ + +G   +L  +     L I     + +GLYTC    + G+ S 
Sbjct: 26504 TGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 26563

Query: 1257  SFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQ 1316
             S  + +           + Q     TP     +   +S         K  E   SQ ++ 
Sbjct: 26564 SCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEA-KSQEKLA 26622

Query: 1317  LEQAGARQVLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGD 1375
             L++  ++ ++  +  +S     E      + ++    S E     ++ +  T ++++EG 
Sbjct: 26623 LKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQ 26682

Query: 1376  DATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGS 1435
                 +  ++    DV W+ NG  +T   +     +GS + LT++     D G +T     
Sbjct: 26683 RLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTC---I 26738

Query: 1436  TATSARLHVRETELLFLRRLQDVRA----------EEGQDVCLEVETGRVGAAGAVRWVR 1485
             + T   +   + +L   + L D  A           EGQ+V    E      +  + W +
Sbjct: 26739 SKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISG-EPSPEIEWFK 26797

Query: 1486  GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDR----TLARLSVRPRQLR 1541
                P+   S +S+++  +++ L I    ++D G Y  ++ + R      A L V P    
Sbjct: 26798 NNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP---L 26854

Query: 1542  VLRPLEDVTISEGGSATFQLELSQEGV--TGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
             V  P  +V +   G  + Q   S + V  +          +        ++     +   
Sbjct: 26855 VEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQ 26914

Query: 1600  GLGLADSGCVSFTADSLRCAARLI-------------VREVPVTIVRGPHDLEVTEGDTA 1646
              +       V  ++ S    + +              +R +P  I   P D+ + EG   
Sbjct: 26915 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 26974

Query: 1647  TFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVG 1703
             T  C  + +   +VTW   G  +    + R     T  L  L +      D G Y+ ++G
Sbjct: 26975 TVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLG 27034



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 113/494 (22%), Positives = 184/494 (37%), Gaps = 82/494 (16%)

Query: 15   LRFPRPVRVVSGAEAELKCVV--LGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
            L+F  P+   +  E E    V  L      VVW K   +L  S  +   ++G  H L + 
Sbjct: 5202 LKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMK 5261

Query: 73   AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                 D    + + +    E  + A + VLE                        P F  
Sbjct: 5262 EVTLDD----ISQIKAQVKELSSTAQLKVLEAD----------------------PYFTV 5295

Query: 133  GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
                +  +   E+ L C      +  + W KDG   +E+  S  ++++        G   
Sbjct: 5296 KLHDKTAVEKDEITLKCEVS--KDVPVKWFKDG---EEIVPSPKYSIK------ADGLRR 5344

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQA---GALLQVHQPPESPPADPDEAPAPVVEPLK 249
             L+I  A L D G YVC        A       L++V            E P   VE   
Sbjct: 5345 ILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKV------------EKPLYGVE--- 5389

Query: 250  CAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL--PDRRRLMYRDRDGGFVLKVL 307
                  +V E  H +     + +P+   +W  +G+PL   PD   +     DG   + +L
Sbjct: 5390 -----VFVGETAHFEIE---LSEPDVHGQWKLKGQPLTASPDCEII----EDGKKHILIL 5437

Query: 308  Y-CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            + CQ    G     A N+     SA  L VKE  L F  PL DV+  E   A  EC+V  
Sbjct: 5438 HNCQLGMTGEVSFQAANAK----SAANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSR 5493

Query: 367  SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
                  W +  Q +    ++E I++GT   ++I     +D+  Y+ E   +  T   + +
Sbjct: 5494 EPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDK-HTSGKLII 5552

Query: 427  KGPILKRLPRKLDVL--EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHA 481
            +G  LK L    DV   E E+AV  VE     +  +W ++ + L     +     G  H+
Sbjct: 5553 EGIRLKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 5612

Query: 482  LVLPGVTREDAGEV 495
            +    ++ +D  ++
Sbjct: 5613 ITFKDLSIDDTSQI 5626



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 63/239 (26%), Positives = 93/239 (38%), Gaps = 32/239 (13%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            +PP  +   + V V+ G    L+C + G P P V W +   Q+ +S             L
Sbjct: 895  TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARL 954

Query: 70   LLTAALPTDAGVYVCRARNAAG-------------EAYAAAAVTVLEPPASDPELQPAER 116
            ++  A   D+G + C A N AG             E +      V E   ++ +     R
Sbjct: 955  MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014

Query: 117  PL---------PSPGSGE-GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGM 166
             +            G GE  AP F+T P  Q ++ G  VV  C+ GG P+P +YW+K G+
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074

Query: 167  ALDEVWD-SSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL 224
             L   +     +  Q G  +        L I      D+G Y    RN HG   A A L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECK--------LVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 92/387 (23%), Positives = 137/387 (35%), Gaps = 78/387 (20%)

Query: 18    PRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPT 77
             PR + V  G  A   C   GEP P V W + GQ L+ S R        +    +++   +
Sbjct: 26195 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQAS 26254

Query: 78    DAGVYVCRARNAAGEAYAAAAVTVL------------------EPPASDPELQPAERPLP 119
             D G Y     N+ G+  A   +T+                   EP    PE   + + + 
Sbjct: 26255 DEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 26314

Query: 120   SPGSG------------------EGAPVFLTGPRSQWVLRGAE---VVLTC--RAGGLPE 156
             SP                     +  PV      +Q++   A      LTC   +  L  
Sbjct: 26315 SPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRA 26374

Query: 157   PTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHG 216
               + W KDG  L E   + HF      + DG   +  L+I      D G YVC      G
Sbjct: 26375 KEVTWYKDGKKLKE---NGHFQFH--YSADG---TYELKINNLTESDQGEYVCEISGEGG 26426

Query: 217   HAQAG------ALLQVHQP--------------PESPPADPDEAPAPVVEPLKCAP---- 252
              ++        A   +H+                ES      E  AP  EP+   P    
Sbjct: 26427 TSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAP--EPISSKPVIVT 26484

Query: 253   --KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
               +   V+    AKF     G+P P   W  +G+ +    +  +  D+ GGF L++    
Sbjct: 26485 GLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDK-GGFFLEIHKTD 26543

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHVK 337
               D GLY C  +NSAG   S+ +L +K
Sbjct: 26544 TSDSGLYTCTVKNSAGSVSSSCKLTIK 26570



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 78/398 (19%)

Query: 22   RVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGLLLTAALPTDA 79
            R++ G      C + G P P + W K G+++   ER  + F  DG    L +   LP D 
Sbjct: 1255 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVLPEDE 1313

Query: 80   GVYVCRARNAAGEAYAAAAVTV-----LEPPASDPELQPAER------------PL---- 118
            G+Y   A N  G A  +  + V     L  P   P L+P  R            P+    
Sbjct: 1314 GIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSP 1373

Query: 119  -----------------PSPG-----SGEG------APVFLTGPRSQWVLRGAEVVLTCR 150
                              SPG     + E        PVF+  P S   L G       +
Sbjct: 1374 ARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLK 1433

Query: 151  AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCH 210
              G P P  +W  DG  +  V D +H  +     EDG   + +L I+ A   DSG +   
Sbjct: 1434 VVGRPMPETFWFHDGQQI--VNDYTHKVV---IKEDG---TQSLIIVPATPSDSGEWTVV 1485

Query: 211  ARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVM 270
            A+N  G +    +L V        A   +     VE L    K   + EG   + +    
Sbjct: 1486 AQNRAGRSSISVILTVE-------AVEHQVKPMFVEKL----KNVNIKEGSRLEMKVRAT 1534

Query: 271  GKPEPEIEWHWEGRPLLPDR-RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTL 329
            G P P+I W      ++P +  ++      G   LK+    ++D   Y   A N AG+  
Sbjct: 1535 GNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDT 1594

Query: 330  SAVQLHVK------EPRLRFTRPLQDVEGREHGIAVLE 361
            +  +++V+      EP  +   P      +E     LE
Sbjct: 1595 TRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELE 1632



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 109/476 (22%), Positives = 177/476 (37%), Gaps = 88/476 (18%)

Query: 45   WEKGGQQL--AASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVL 102
            W K G ++     ER  +  +   H + ++    +DAG Y   A      +     V   
Sbjct: 3133 WYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVA--GRNRSSVTLYVNAP 3190

Query: 103  EPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWE 162
            EPP    ELQP                         V  G          G P+P + W 
Sbjct: 3191 EPPQVLQELQPVT-----------------------VQSGKPARFCAVISGRPQPKISWY 3227

Query: 163  KDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGA 222
            K+   L   +                G    L ++ A   D+ VY C A+N +G A   A
Sbjct: 3228 KEEQLLSTGFKCKFLH---------DGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSA 3278

Query: 223  LLQVHQPPE-SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHW 281
             L V  P   SP  +    P  ++ PL+        +EG+ A+F+C V G  + ++ W+ 
Sbjct: 3279 SLSVEVPEVVSPDQEMPVYPPAIITPLQDTV----TSEGQPARFQCRVSGT-DLKVSWYS 3333

Query: 282  EGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL------- 334
            + + + P R   M +  D  + L++     +D G Y   A N+ GQ  S   L       
Sbjct: 3334 KDKKIKPSRFFRMTQFEDT-YQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEGFSK 3392

Query: 335  ----------HV-------KEP---RLRFTRPLQDVEGREHGIAVLECKVPNSRIP---T 371
                      HV       KEP   +  F +PL  +  R H    +      S IP    
Sbjct: 3393 FEENTSNSQWHVSLSVSFKKEPLGQKPSFIQPLSSL--RVHNGETVRFHARVSGIPKPEI 3450

Query: 372  AWFREDQRLLPCRKYE-QIEEGT-VRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTV 426
             WF   Q +LP +      EE T +  ++I    ++  G Y C+     G     A +TV
Sbjct: 3451 QWFHNQQLILPTKDVVFHFEESTGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTV 3510

Query: 427  --KGP---ILKRLPRKLDVLEGENAVLLVETLEAGV---EGRWSRDGEELPVICQS 474
              K P   + +R+ +++++   E +   +   E G+   E + S+  E L ++ +S
Sbjct: 3511 TPKAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSES 3566



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 123/502 (24%), Positives = 190/502 (37%), Gaps = 74/502 (14%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
            G+ A  +C+V      +  W K G  +  S +  F ADG +  L +     +DAG Y C 
Sbjct: 4761 GSSAIFECLV-SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 4819

Query: 86   ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145
             R    E  + A + V E P                          T      V++G  +
Sbjct: 4820 LRLGNKEKTSTAKLVVEELPVR---------------------FVKTLEEEVTVVKGQPL 4858

Query: 146  VLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP-GASLALRILAARLPDS 204
             L+C      E  + W KDG  + E         +PGR   G  G   AL I  A   D+
Sbjct: 4859 YLSCELN--KERDVVWRKDGKIVVE---------KPGRIVPGVIGLMRALTINDADDTDA 4907

Query: 205  GVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAK 264
            G Y     NA+ + +  + ++V +               +V+P+    +   V     A 
Sbjct: 4908 GTYTVTVENAN-NLECSSCVKVVEVIRD----------WLVKPI----RDQHVKPKGTAI 4952

Query: 265  FRCYVMGKPEPEIEWH--WEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
            F C +  K  P I+W   ++  P  P+ +  + RD      LK+     +D   Y   A 
Sbjct: 4953 FACDI-AKDTPNIKWFKGYDEIPAEPNDKTEILRD-GNHLYLKIKNAMPEDIAEY---AV 5007

Query: 323  NSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLP 382
               G+   A +L + E  +   +P++DV   E   A  + ++  + IP  W  + + L P
Sbjct: 5008 EIEGKRYPA-KLTLGEREVELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRP 5066

Query: 383  CRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLE 442
                E   EG  R L +H++K D  G  L +    + T A +TVK   L       DV  
Sbjct: 5067 SPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAI-TTAILTVKEIELDFAVPLKDVTV 5125

Query: 443  GENAVLLVE---TLEAGVEGRWSRDGEELPVICQSS-------SGHMHALVLPGVTREDA 492
             E      E   T EA V   WS+     P I +SS        G  H LV+     +D 
Sbjct: 5126 PERRQARFECVLTREANV--IWSKG----PDIIKSSDKFDIIADGKKHILVINDSQFDDE 5179

Query: 493  GEVTFSLGNSRTTTLLRVKCVK 514
            G  T  +   +T+  L V  ++
Sbjct: 5180 GVYTAEVEGKKTSARLFVTGIR 5201



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 57/227 (25%), Positives = 87/227 (38%), Gaps = 10/227 (4%)

Query: 2    KASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFP 61
            K  S  +G+ P F++      +  G  A L   V+G P P + W   G  L  S    F 
Sbjct: 3572 KFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFV 3631

Query: 62   ADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPA--SDPELQPAERPLP 119
             DG +H L++      D G Y C A N  G+   +A + +        D E + A     
Sbjct: 3632 FDGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSL 3691

Query: 120  SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                G   P FL   +     +G   +      G P PT+ W K+     ++  S ++ +
Sbjct: 3692 EKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKEN---KQLCTSVYYTI 3748

Query: 180  QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
                    P  S    +   +  DSG+Y+C A N  G +   A L V
Sbjct: 3749 -----IHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3790



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 118/552 (21%), Positives = 194/552 (35%), Gaps = 105/552 (19%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGL 69
            P F+  P   ++V G      C V G P P V W+K G  L    R  +S+     E  L
Sbjct: 1036 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1095

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL---------PS 120
            +++     DAG Y    RN  GE   +A+ ++LE    +  ++  +  L           
Sbjct: 1096 VISMTFADDAGEYTIVVRNKHGET--SASASLLEEADYELLMKSQQEMLYQTQVTAFVQE 1153

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
            P  GE AP F+     +   +   ++    A        Y E      D+ +  S F   
Sbjct: 1154 PKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE------DQEFHISSF--- 1204

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240
                E+     +  RI+   L +                    L      E    D  E+
Sbjct: 1205 ----EERLIKEIEYRIIKTTLEE--------------------LLEEDGEEKMAVDISES 1240

Query: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
             A V        K + + EG    F C + G P P+I W+ +G+ +    R  M   +DG
Sbjct: 1241 EA-VESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1299

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK--------------EPRLRFTRP 346
               L++     +D G+Y   A N  G  + + +L+V+              EP  R  R 
Sbjct: 1300 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRI-RS 1358

Query: 347  LQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADD 406
            L         I +   ++  +R+  A      R+ P R+ E+ +E  + RL         
Sbjct: 1359 LSPRSVSRSPIRMSPARMSPARMSPARM-SPARMSPGRRLEETDESQLERLY-------- 1409

Query: 407  DGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGV-EGRWSRDG 465
                                  P+    P     LEG+ A   ++ +   + E  W  DG
Sbjct: 1410 ---------------------KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDG 1448

Query: 466  EEL-----PVICQSSSGHMHALVLPGVTREDAGEVTF----SLGNSRTTTLLRVKCVKHS 516
            +++       +     G    +++P  T  D+GE T       G S  + +L V+ V+H 
Sbjct: 1449 QQIVNDYTHKVVIKEDGTQSLIIVP-ATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQ 1507

Query: 517  PPGPPILAEMFK 528
                P+  E  K
Sbjct: 1508 V--KPMFVEKLK 1517



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 91/395 (23%), Positives = 142/395 (35%), Gaps = 87/395 (22%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA--EHGL 69
            P F+   + V +  G+  E+K    G P P +VW K    +   +      +G   E  L
Sbjct: 1510 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1569

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP-------- 121
             + + +  D+  Y   A N AG       V V E   ++PE    ER L  P        
Sbjct: 1570 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNV-EVEFAEPE---PERKLIIPRGTYRAKE 1625

Query: 122  -GSGEGAPVFLTGPRSQW------------------------VLRGAEVVLTCRAGGLPE 156
              + E  P+ L   + QW                        + R       CR   + +
Sbjct: 1626 IAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGD 1685

Query: 157  PTLY--WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
            PT+   W  DG  L+        A +     +    SL   +  +R  DSG+  C A N 
Sbjct: 1686 PTMVVEWLHDGKPLEA-------ANRLRMINEFGYCSLDYGVAYSR--DSGIITCRATNK 1736

Query: 215  HGHAQAGA---------LLQVHQPPESPPA---------------------DPDEAPAPV 244
            +G     A         L++  Q PE                         D  E   P 
Sbjct: 1737 YGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKP- 1795

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFV 303
               +   P+   V EG+ A+FRC V G P+P++ W+  G+ +   +R R+ Y   DG   
Sbjct: 1796 --DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHY 1850

Query: 304  LKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
            L ++ C++ D G     A N  G     V+L +++
Sbjct: 1851 LDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1885



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 113/549 (20%), Positives = 201/549 (36%), Gaps = 46/549 (8%)

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT---------V 981
             WTKDG+ + +     L ++     L +      DSG Y C + + + S +         +
Sbjct: 26513 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAI 26572

Query: 982   TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
               TE          E+T      +  V+  E+S++       K   E +  E L L+ + 
Sbjct: 26573 KDTEAQKVSTQKTSEIT----PQKKAVVQEEISQKALRSEEIKMS-EAKSQEKLALKEEA 26627

Query: 1042  PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAAR--SLDLHFGAPGRV 1099
              +   VL + + +       +        T T  A  E   H   +  S  +      R+
Sbjct: 26628 SK---VLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 26684

Query: 1100  ELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR-HE 1158
              L+  +A A + V+W  +G+E+  S+  + G  G  +TLT+  A   D G   C ++  E
Sbjct: 26685 VLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKE 26743

Query: 1159  AIT---FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQ 1214
              I    +++ L++      A  + P    +  G+ V+ +CE+S   +P + W  N  P+ 
Sbjct: 26744 GIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS 26803

Query: 1215  EGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS----GAAPGAPSLSFTVQVAEPPVRVV 1270
                 + +        L I+ A  + +G YT ++    G      SL     V EP   VV
Sbjct: 26804 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 26863

Query: 1271  APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQ------GRVQLEQAGARQ 1324
                +  T   S  G      V +S       +       AS         +  +   + Q
Sbjct: 26864 LRTSGDT---SLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQ 26920

Query: 1325  VLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE- 1382
                V+ + S   G   +      +   L +    +  K+ +  + +++ EG   T  C  
Sbjct: 26921 ESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAF 26980

Query: 1383  VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL--RGCQLGDAGTVTL----RAGST 1436
                P  +VTW   G  +    Q       +  + TL     Q  D G  TL      GS 
Sbjct: 26981 TGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSD 27040

Query: 1437  ATSARLHVR 1445
             + +  +H+R
Sbjct: 27041 SATVNIHIR 27049



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 60/208 (28%), Positives = 78/208 (37%), Gaps = 29/208 (13%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASE---RLSFPADGAEHGLLLTAALPTDAGVY 82
             G        +   P P V W K GQ++   +   + +F +D   + L + +    D   Y
Sbjct: 25332 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 25391

Query: 83    VCRARNAAGEAYAAAAVTV-LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLR 141
                ARN  GE    A +TV L PP +D  L+P  + L            L     Q    
Sbjct: 25392 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRL------------LANAECQ---E 25436

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS-LALRILAAR 200
             G  V    R  G+P PTL WEKDG  L         +L P       G    AL I    
Sbjct: 25437 GQSVCFEIRVSGIPPPTLKWEKDGQPL---------SLGPNIEIIHEGLDYYALHIRDTL 25487

Query: 201   LPDSGVYVCHARNAHGHAQAGALLQVHQ 228
               D+G Y   A N  G     A LQV +
Sbjct: 25488 PEDTGYYRVTATNTAGSTSCQAHLQVER 25515



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 57/217 (26%), Positives = 83/217 (38%), Gaps = 30/217 (13%)

Query: 17    FPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALP 76
             F   + +  G    LK  + G     V W   G +L  SE   +   G++  L +  A  
Sbjct: 26672 FSTQMSINEGQRLVLKANIAGATD--VKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASH 26729

Query: 77    TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRS 136
              D G+  C ++   G       +T L    SD                  AP F++ PRS
Sbjct: 26730 RDEGILTCISKTKEGIVKCQYDLT-LSKELSD------------------APAFISQPRS 26770

Query: 137   QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRI 196
             Q +  G  V+ TC   G P P + W K+ + +     SS+ ++   R         +L I
Sbjct: 26771 QNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS---ISSNVSISRSR------NVYSLEI 26821

Query: 197   LAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               A + DSG Y   A+N  G   A A L V    E P
Sbjct: 26822 RNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEP 26858



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 81/369 (21%), Positives = 132/369 (35%), Gaps = 67/369 (18%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLA--ASERLSFPADGAEHGL 69
            P F+  P   + + G  A     V+G P P   W   GQQ+    + ++    DG +  L
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-SL 1469

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
            ++  A P+D+G +   A+N AG +  +  +TV          +  E  +         P+
Sbjct: 1470 IIVPATPSDSGEWTVVAQNRAGRSSISVILTV----------EAVEHQV--------KPM 1511

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
            F+   ++  +  G+ + +  RA G P P + W K+    D +    +    P    +G  
Sbjct: 1512 FVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS---DIIVPHKY----PKIRIEGTK 1564

Query: 190  ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPAD-----------PD 238
               AL+I +    DS  Y   A N  G       + V      P  +             
Sbjct: 1565 GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAK 1624

Query: 239  EAPAPVVEPLKCAPKTFWVNEG---------------------------KHAKFRCYVMG 271
            E  AP +EPL          EG                            H + R   +G
Sbjct: 1625 EIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIG 1684

Query: 272  KPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
             P   +EW  +G+P L    RL   +  G   L      ++D G+  C A N  G   ++
Sbjct: 1685 DPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTS 1743

Query: 332  VQLHVKEPR 340
              L VK+ +
Sbjct: 1744 ATLIVKDEK 1752



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 193/1091 (17%), Positives = 363/1091 (33%), Gaps = 146/1091 (13%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G++ +F   V  KP  E++W+  G   L +  ++ Y +  G   L++L C   D G Y  
Sbjct: 26016 GQNTRFILNVQSKPTAEVKWYHNGVE-LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRA 26074

Query: 320   AARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECK---VPNSRIPTAWFRE 376
                N  G+      L              DV G ++     + +   VP S  P     E
Sbjct: 26075 VCTNYKGEASDYATL--------------DVTGGDYTTYASQRRDEEVPRSVFPELTRTE 26120

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGI--YLCEMRGRVRTVA------------ 422
                +   +K  ++E  +  R +  ++    + +  Y       +++ A            
Sbjct: 26121 AYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTT 26180

Query: 423   ---NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ---SS 475
                  T+   IL + PR + V EGE+A    +T    V    W R G+ L    +   ++
Sbjct: 26181 RKIKTTLAARILTK-PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTT 26239

Query: 476   SGHMHALVLPGVTREDAGEVTFSLGNSR-------TTTLLRVKCVKHSPPGPPIL----- 523
             + +     +  V   D G  +  + NS        T T+ + +  + +   PP +     
Sbjct: 26240 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 26299

Query: 524   ----AEMFKGHKNTVLLTWKPPEPA----------PETPFIYRLERQEVGSEDWIQCFSI 569
                  E  K  K       K PEP+            TP   +++   V +   I  F  
Sbjct: 26300 RVKSPEAVKSPKRV-----KSPEPSHPKAVSPTETKPTP-TEKVQHLPVSAPPKITQFLK 26353

Query: 570   EKAGAVEVPGDCVPSEGDYRFRICTVSGHGR----SPHVVFHGSAHLVPTARLVAGLEDV 625
              +A        CV      R +  T    G+    + H  FH SA               
Sbjct: 26354 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSA--------------- 26398

Query: 626   QVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI--L 683
                   D  + L ++ + +      GE +     EG      L++  +     H  +  +
Sbjct: 26399 ------DGTYELKINNLTESD---QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 26449

Query: 684   HAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV 743
                K  D            +  A   I   PV +   QD    + + ++  V      R 
Sbjct: 26450 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 26509

Query: 744   DFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
                A W KDG+ + +     +  D     L + +    DSG + C  +  +     + + 
Sbjct: 26510 --TAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 26567

Query: 804   PPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQ----EVEESDFVVLENEG 859
                 I D          TSE       V +E+   +  +  +    E +  + + L+ E 
Sbjct: 26568 TIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEA 26627

Query: 860   PHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLT 919
                 +     + +     + +  +E    +    +V +     +    ++    +R+VL 
Sbjct: 26628 SKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLK 26687

Query: 920   CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESA-- 977
               +     +V+W  +G E+  S         + + L +      D G   C    +    
Sbjct: 26688 ANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIV 26746

Query: 978   ------SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVE 1030
                   + +  +++ P  I  PR +        + V+  CE+S E +P + W+K+ L + 
Sbjct: 26747 KCQYDLTLSKELSDAPAFISQPRSQNINEG---QNVLFTCEISGEPSPEIEWFKNNLPIS 26803

Query: 1031  ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLD 1090
              S  + + R      L +  A   D G++   A +     + T +     +V   +R + 
Sbjct: 26804 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 26863

Query: 1091  LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE 1150
             L     G   L+   +    Q+   K      +  +    +    +  ++         E
Sbjct: 26864 LR--TSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQE 26921

Query: 1151  YVCE------------TRHEAITFNVILAE----PPVQFLALETTPSPLCVAPGEPVVLS 1194
                E            T+ E+ T  ++ A     PP     +E  PS + +  G+ + ++
Sbjct: 26922 SFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPP----KIEALPSDISIDEGKVLTVA 26977

Query: 1195  CELSRAGAP-VVWSHNGRPVQEGEGLELHAEG--PRRVLCIQAAGPAHAGLYTCQSGAAP 1251
             C  +    P V WS  GR +   E    H E       L I        GLYT   G   
Sbjct: 26978 CAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEF 27037

Query: 1252  GAPSLSFTVQV 1262
             G+ S +  + +
Sbjct: 27038 GSDSATVNIHI 27048



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 60/241 (24%), Positives = 80/241 (33%), Gaps = 46/241 (19%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P  ++G ++  V+ G  V L C   G P PT+ W ++   ++   D      Q G A   
Sbjct: 897  PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIAR-- 953

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE---------------- 231
                  L I  A   DSG + C A N  G       L V    E                
Sbjct: 954  ------LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1007

Query: 232  -----------------SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                                A P E  AP         K     EG    F C V G P+
Sbjct: 1008 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV---EGGSVVFGCQVGGNPK 1064

Query: 275  PEIEWHWEGRPLLPD-RRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQ 333
            P + W   G PL    R ++ Y  + G   L +    A D G Y    RN  G+T ++  
Sbjct: 1065 PHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASAS 1124

Query: 334  L 334
            L
Sbjct: 1125 L 1125



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 69/279 (24%), Positives = 113/279 (40%), Gaps = 54/279 (19%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE----RLSFPADGAEH 67
           P F +  + V V+ G+ A  +  + G P P V W + GQ ++ S     ++SF    A+ 
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK- 64

Query: 68  GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            L + A    ++G Y  +A N +G+A + A + V    A                     
Sbjct: 65  -LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA--------------------P 103

Query: 128 PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
           P F+   +S  V +G++V L  R  G+P P + + +DG    E+  S  F +        
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGA---EIQSSLDFQISQ------ 154

Query: 188 PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
            G   +L I  A   DSG Y  +A N+ G A + A L V    E P            + 
Sbjct: 155 EGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVP-----------AKK 203

Query: 248 LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            K    T  ++E +  +         E +IE H++ R +
Sbjct: 204 TKTIVSTAQISESRQTRI--------EKKIEAHFDARSI 234



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 63/225 (28%), Positives = 91/225 (40%), Gaps = 30/225 (13%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD---GAEHG 68
             P F    R + V   + A L C V G P P+V W + G+++ A + L +      G  H 
Sbjct: 24556 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIA-DGLKYRIQEFKGGYHQ 24614

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
             L++ +    DA VY  RA N  G     A++ V           PA+  LP    G GA 
Sbjct: 24615 LIIASVTDDDATVYQVRATNQGGSVSGTASLEV---------EVPAKIHLPKTLEGMGA- 24664

Query: 129   VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                        LRG  V +     G P+P + W+K    +D   ++ H+ +   R+    
Sbjct: 24665 --------VHALRGEVVSIKIPFSGKPDPVITWQKGQDLID---NNGHYQVIVTRS---- 24709

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               SL       R  D+G YV  A+N  G  Q    L V   P+ P
Sbjct: 24710 FTSLVFPNGVER-KDAGFYVVCAKNRFGIDQKTVELDVADVPDPP 24753



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG-L 69
            PP FL+  +P+R   G  A  +  V+GEP P V W K  +QL  S   +   +    G  
Sbjct: 3699 PPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTF 3758

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVL 102
            ++      D+G+Y+C+A N  GE+  AA + VL
Sbjct: 3759 IVNDPQREDSGLYICKAENMLGESTCAAELLVL 3791



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 120/558 (21%), Positives = 202/558 (36%), Gaps = 73/558 (13%)

Query: 492   AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
             A E    +G     ++    C    PPGPP   ++    +++V L W  P      P   
Sbjct: 18605 AAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKG 18664

Query: 551   YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSA 610
             Y +E +E  +++W  C         +     +    +Y FRIC ++  G        GS 
Sbjct: 18665 YVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSV 18724

Query: 611   HLV-----PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEP 665
                     P   L A L  V V     A  +L L   I+G       E+K  + EG +  
Sbjct: 18725 VAQERIEPPEIELDADLRKVVVLR---ASATLRLFVTIKGR---PEPEVKWEKAEGILTD 18778

Query: 666   GALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVS 725
                R +IE       L++  V   DSG    ++     +S + T   +   + SP   V+
Sbjct: 18779 ---RAQIEVTSSFTMLVIDNVTRFDSGR---YNLTLENNSGSKTAFVNVRVLDSPSAPVN 18832

Query: 726   LTF--TTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAKVQD 782
             LT      + V L+ E   +D        G K+  +  +V K +  RK    +     + 
Sbjct: 18833 LTIREVKKDSVTLSWEPPLID-------GGAKI--TNYIVEKRETTRKAYATITNNCTKT 18883

Query: 783   SGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDREDAP 837
             +   E   EG S +F V   +      P    +P + V    +    V L  +V R  A 
Sbjct: 18884 TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVK-VSEPPLPPGRVTLV-DVTRNTAT 18941

Query: 838   VRWYK---DGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
             ++W K   DG        V ++ +G  +       +  +       AG+E  +    + +
Sbjct: 18942 IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNE 19001

Query: 895   -------------------VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
                                +   +  P     V A    ++ +  +  RP A V W KDG
Sbjct: 19002 KGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFK-GRPQATVNWRKDG 19060

Query: 936   EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT---------EP 986
             + + E+  + +    TV  L +     ED G Y   + + + S TV +T           
Sbjct: 19061 QTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPG 19120

Query: 987   PVRIIYPRDEVTLIAVTL 1004
             P+RI    DEV+  ++T+
Sbjct: 19121 PIRI----DEVSCDSITI 19134



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 75/318 (23%), Positives = 117/318 (36%), Gaps = 24/318 (7%)

Query: 43    VVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV- 101
             V W  G +QL  SE+     +     L +      D G Y C+  N  GE  + A + V 
Sbjct: 25228 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 25287

Query: 102   ----LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
                 +        ++  +R   +    E  P F     ++    G  V         PEP
Sbjct: 25288 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 25347

Query: 158   TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
              + W K G  +    +   +  +  +          L I +    D   Y   ARN +G 
Sbjct: 25348 HVTWYKSGQKIKPGDNDKKYTFESDKG------LYQLTINSVTTDDDAEYTVVARNKYGE 25401

Query: 218   AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
                 A L V   P  PP D    P       K         EG+   F   V G P P +
Sbjct: 25402 DSCKAKLTVTLHP--PPTDSTLRPM-----FKRLLANAECQEGQSVCFEIRVSGIPPPTL 25454

Query: 278   EWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             +W  +G+PL L     +++   D  + L +     +D G Y   A N+AG T  + Q H+
Sbjct: 25455 KWEKDGQPLSLGPNIEIIHEGLD-YYALHIRDTLPEDTGYYRVTATNTAGST--SCQAHL 25511

Query: 337   KEPRLRFTRPLQDVEGRE 354
             +  RLR+ +  Q+ + +E
Sbjct: 25512 QVERLRYKK--QEFKSKE 25527



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 144/696 (20%), Positives = 245/696 (35%), Gaps = 128/696 (18%)

Query: 252   PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
             P++  V EG+ A+F C   G+P P + W  +G+ L    R  +   +      ++   QA
Sbjct: 26195 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKS-TFEISSVQA 26253

Query: 312   KDRGLYVCAARNSAGQTLSAVQLHVKEPRL---------RFTRPLQDVEGREHGIAVLEC 362
              D G Y     NS G+  +   L +++ R+         R   P   V+  E   +    
Sbjct: 26254 SDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRV 26313

Query: 363   KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
             K P    P A    + +  P  K + +      + I   LKA+             + +A
Sbjct: 26314 KSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPK-ITQFLKAEAS-----------KEIA 26361

Query: 423   NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHM--- 479
              +T                  E++VL  +      E  W +DG++L       +GH    
Sbjct: 26362 KLT---------------CVVESSVLRAK------EVTWYKDGKKL-----KENGHFQFH 26395

Query: 480   ------HALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKG 529
                   + L +  +T  D GE    +    G S+T      +  K        ++E  K 
Sbjct: 26396 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKS 26455

Query: 530   HKNTVLLTW------KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE------V 577
              + T   T       K PEP    P I    +    S D +  F+++  G          
Sbjct: 26456 DQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK 26515

Query: 578   PGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSL 637
              G  +   G Y+                F    H   T+   +GL    V +   +V S 
Sbjct: 26516 DGKAITQGGKYKL---------SEDKGGFFLEIHKTDTSD--SGLYTCTVKNSAGSVSSS 26564

Query: 638   DLSTI--IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH---------AV 686
                TI  I+ T        K++E   Q +   ++  I QK L+   I           A+
Sbjct: 26565 CKLTIKAIKDTEAQKVSTQKTSEITPQ-KKAVVQEEISQKALRSEEIKMSEAKSQEKLAL 26623

Query: 687   KHQDSGALVGFSCPGVQDSAALTIQESPVH-------ILSPQDR---------VSLTFTT 730
             K + S  L+      V+ SAA ++++S VH         S + R           ++   
Sbjct: 26624 KEEASKVLIS---EEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINE 26680

Query: 731   SERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC-- 788
              +R+VL   ++       W  +G ++  SE     + G    L + +A  +D G   C  
Sbjct: 26681 GQRLVLKANIAGAT-DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCIS 26739

Query: 789   -RTEG-VSAFFGVT----VQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWY 841
                EG V   + +T    + D P  I  PR     +    + V+  CE+  E +P + W+
Sbjct: 26740 KTKEGIVKCQYDLTLSKELSDAPAFISQPRSQ---NINEGQNVLFTCEISGEPSPEIEWF 26796

Query: 842   KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEF 877
             K+   +  S  V +        L +     SD G++
Sbjct: 26797 KNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 26832



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/115 (27%), Positives = 50/115 (43%)

Query: 9     GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
             G  P   +  + V    G  A+L C ++G P P + W + G++L  S +    +DG  H 
Sbjct: 24158 GEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT 24217

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGS 123
             L +      D GVY C A N  GE   ++ + +   P   P     E+   + GS
Sbjct: 24218 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGS 24272



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 81/379 (21%), Positives = 133/379 (35%), Gaps = 82/379 (21%)

Query: 131   LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD--------------------- 169
             LT PRS  V  G     +C   G P PT+ W + G  L                      
Sbjct: 26192 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 26251

Query: 170   EVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGV-YVCHARNAHGHAQAGALLQVHQ 228
             +  D  ++++    +E    A   L I  AR+ +  V      ++     ++   ++  +
Sbjct: 26252 QASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPK 26311

Query: 229   PPESP-PADP------DEAPAPVVE----PLKCAPK--TFWVNEGKH--AKFRCYVMGK- 272
               +SP P+ P      +  P P  +    P+   PK   F   E     AK  C V    
Sbjct: 26312 RVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSV 26371

Query: 273   -PEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
                 E+ W+ +G+ L  +     +   DG + LK+      D+G YVC      G + + 
Sbjct: 26372 LRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTN 26431

Query: 332   VQ--------LHVKEPRL----------------RFTRP---------------LQDVEG 352
             +Q        +H K  ++                R T P               LQD   
Sbjct: 26432 LQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTV 26491

Query: 353   REHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL 411
                 +A    K      PTA W ++ + +    KY+  E+     L IH+    D G+Y 
Sbjct: 26492 SSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYT 26551

Query: 412   CEMR---GRVRTVANVTVK 427
             C ++   G V +   +T+K
Sbjct: 26552 CTVKNSAGSVSSSCKLTIK 26570



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 44/164 (26%), Positives = 77/164 (46%), Gaps = 10/164 (6%)

Query: 1366 LTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPG--PQVEMAQNGSSRILTLRGCQ 1422
            L  + V EG  ATF   +S  P  +V+W R+G V++    P V+++ +     LT+    
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVT 71

Query: 1423 LGDAGTVTLRA----GSTATSARLHVRETELL--FLRRLQDVRAEEGQDVCLEVETGRVG 1476
              ++G  +L+A    G   ++A L V+       F++RLQ +   +G  V L+V    + 
Sbjct: 72   KANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIP 131

Query: 1477 AAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
                V++ R G  +       ++Q+G ++ L I      D GTY
Sbjct: 132  TP-VVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTY 174



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 12/141 (8%)

Query: 1020 VRWYKDGLEVEESE--ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV--- 1074
            V W++DG  +  S    + +     R +L +PA    + G +   A + S   T T    
Sbjct: 37   VSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELL 96

Query: 1075 ----TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
                TAPP  +     +S+ +  G+  R+++R    P    V++Y+DG E+++S   Q+ 
Sbjct: 97   VKAETAPPNFVQR--LQSMTVRQGSQVRLQVRVTGIPT-PVVKFYRDGAEIQSSLDFQIS 153

Query: 1131 AEGPTRTLTLPHAQPEDAGEY 1151
             EG   +L +  A PED+G Y
Sbjct: 154  QEGDLYSLLIAEAYPEDSGTY 174



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 71/338 (21%), Positives = 130/338 (38%), Gaps = 44/338 (13%)

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
             G+   L I  A   D G+  C ++   G  +    L + +       +  +APA + +P 
Sbjct: 26717 GSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSK-------ELSDAPAFISQP- 26768

Query: 249   KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
                 ++  +NEG++  F C + G+P PEIEW     P+       + R R+  + L++  
Sbjct: 26769 ----RSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRN-VYSLEIRN 26823

Query: 309   CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
                 D G Y   A+N  GQ  +   L V         P ++V  R  G   L+    +  
Sbjct: 26824 ASVSDSGKYTIKAKNFRGQCSATASLMVLP---LVEEPSREVVLRTSGDTSLQGSFSSQS 26880

Query: 369   IPTAWFREDQRL----------LPCRKYEQIEE---GTVRRLIIHRLKADDDGI-YLCEM 414
             +  +  +++             +   K+  +      +++   +    +   GI  + ++
Sbjct: 26881 VQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQL 26940

Query: 415   RGRVRTVANVTVKG--PILKRLPRKLDVLEGE-NAVLLVETLEAGVEGRWSRDGEELPVI 471
                   +    ++G  P ++ LP  + + EG+   V    T E   E  WS  G +   I
Sbjct: 26941 ESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRK---I 26997

Query: 472   CQSSSGHMH--------ALVLPGVTREDAGEVTFSLGN 501
                  G  H         L++  V ++D G  T SLGN
Sbjct: 26998 HSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 27035



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 97/418 (23%), Positives = 155/418 (37%), Gaps = 52/418 (12%)

Query: 373  WFREDQRLLPCRKYEQIEEGTVR-RLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
            W R + R +   K++ +EEG V  +  + R++A    +    +        NV  K P  
Sbjct: 7959 WMRVNSRPIKDLKFK-VEEGVVPDKEYVLRVRA----VNAIGVSEPSEISENVVAKDPDC 8013

Query: 432  KRL----PRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHA---LV 483
            K         + V+EGE   + V      V    W +DG+E+    + +  + H    L 
Sbjct: 8014 KPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLE 8073

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP 543
            +P   R DAG  T +L N   +    +       PGP    +     K++  LTW+PPE 
Sbjct: 8074 VPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEF 8133

Query: 544  APETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
               TP + Y LER+E G   +I   S E   +  V  D +P+ G+Y FR+  V+  G   
Sbjct: 8134 DGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVK-DLIPN-GEYFFRVKAVNKVGGGE 8191

Query: 603  HVVFHGSAHLV----------------PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG- 645
            ++                         PTA  +       +YDG   +    +  I +G 
Sbjct: 8192 YIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGE 8251

Query: 646  -TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD 704
              W    E L             L Y    KGL+           ++ A +         
Sbjct: 8252 ERWKRCNEHLVP----------ILTY--TAKGLEEGKEYQFRVRAENAAGISEPSRATPP 8299

Query: 705  SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESEL 761
            + A+   ++P  IL    R SL     + + L   +S   +P  TW KD   +   E+
Sbjct: 8300 TKAVDPIDAPKVIL----RTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEI 8353



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 24/209 (11%)

Query: 413   EMRGRVRTVANVTVKGP-------ILKRLPRKLDVLEGENAVLLVET-----LEAGVEGR 460
             + R   RT  N++           + + +P ++D+     ++L V+      L+A V G+
Sbjct: 12891 QFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGK 12950

Query: 461   ------WSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 511
                   W +DG  L     I  +   ++  L L  V R+D+G+ T +  NS  +    +K
Sbjct: 12951 PMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIK 13010

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPP-EPAPETPFIYRLERQEVGSEDWIQCFSIE 570
                   PGPP   ++ K + +  +L+W+PP E        Y ++++E    +W Q  +  
Sbjct: 13011 LKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATV 13070

Query: 571   KAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                +  V  + +    +Y+FRIC  + +G
Sbjct: 13071 PITSCSV--EKLIEGHEYQFRICAENKYG 13097



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 100/471 (21%), Positives = 191/471 (40%), Gaps = 59/471 (12%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G+ A+  C ++G+P P+I+W+  G+ L+  R+  M  D      L V+  + +D G+Y C
Sbjct: 24175 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSD-GRTHTLTVMTEEQEDEGVYTC 24233

Query: 320   AARNSAGQTLSAVQLHVK-EPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFRED 377
              A N  G+  ++ +L ++  P+     PL++   G       L        +P   +   
Sbjct: 24234 IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHG 24293

Query: 378   QRLLPCRKYEQIEE-----GTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKG-PIL 431
             Q+LL   +   IE        V + +  +  A    + L  + G V  + +V ++  P  
Sbjct: 24294 QKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDK 24353

Query: 432   KRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVT--- 488
                P  ++ L   +AV+  +   A   G W  +   +   C++  G    LV   ++   
Sbjct: 24354 PTGPIVIEALLKNSAVISWKP-PADDGGSWITN--YVVEKCEAKEGAEWQLVSSAISVTT 24410

Query: 489   ------REDAG-------EVTFSLGNS---RTTTLLRVKCVKHSPPGPPILAEMFKGHKN 532
                    E+AG       + TF + +     +  +++    K   PG P +  +    K+
Sbjct: 24411 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAV---TKD 24467

Query: 533   TVLLTWKPPEPAPETPF-IYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DYRF 590
             + ++ WKPP          Y LE++E     WI   + E    V    + +  EG +Y F
Sbjct: 24468 SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLI--EGLEYEF 24525

Query: 591   RICTVSGHGRS-----PHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS----T 641
             R+   +  G S        +   S   +        L ++ V    +A     ++     
Sbjct: 24526 RVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKP 24585

Query: 642   IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQ-KGLQHRLILHAVKHQDS 691
             I++  W+  G+E+ ++          L+YRI++ KG  H+LI+ +V   D+
Sbjct: 24586 IVK--WYRQGKEIIAD---------GLKYRIQEFKGGYHQLIIASVTDDDA 24625



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 54/214 (25%), Positives = 86/214 (40%), Gaps = 27/214 (12%)

Query: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD-EVWDSSHFALQPGRAE 185
           AP F    +S  VL G+         G P P + W +DG  +          +   GRA+
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64

Query: 186 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
                   L I A    +SG Y   A N  G A + A L V           + AP   V
Sbjct: 65  --------LTIPAVTKANSGRYSLKATNGSGQATSTAELLV---------KAETAPPNFV 107

Query: 246 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 305
           + L    ++  V +G   + +  V G P P ++++ +G  +   +  L ++    G +  
Sbjct: 108 QRL----QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI---QSSLDFQISQEGDLYS 160

Query: 306 VLYCQA--KDRGLYVCAARNSAGQTLSAVQLHVK 337
           +L  +A  +D G Y   A NS G+  S  +L V+
Sbjct: 161 LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 81/338 (23%), Positives = 134/338 (39%), Gaps = 47/338 (13%)

Query: 700  PGVQDSAALTIQESPVHILSPQDRVSLTF--TTSERVVLTCELSRVDFPA-TWYKDGQKV 756
            P +Q  A  ++QE        Q    +T     S+ ++ T E+S  +  +   Y D   V
Sbjct: 4255 PRIQQGAKTSLQEEMDSFSGSQKVEPITEPEVESKYLISTEEVSYFNVQSRVKYLDATPV 4314

Query: 757  EESELLVVKMDGRKHRLILP----EAKVQDSGEFECRTEGVSAFFGVTVQD--PPVH--I 808
             +     V  D ++   + P    E    +SG  E  T  +    G  +++  P +H  +
Sbjct: 4315 TKGVASAVVSDEKQDESLKPSEEKEESSSESGTEEVATVKIQEAEGGLIKEDGPMIHTPL 4374

Query: 809  VDP--REHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESD-FVVLENEGPHRRLV 865
            VD    E   VH  TS  +  A EV+       WY + + V   + F  L+++  +  ++
Sbjct: 4375 VDTVSEEGDIVHLTTS--ITNAKEVN-------WYFENKLVPSDEKFKCLQDQNTYTLVI 4425

Query: 866  LPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVL------T 919
                     GE+ C A ++      T T     +V  +  V    +    V L      T
Sbjct: 4426 DKVNTEDHQGEYVCEALNDSGK---TATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFT 4482

Query: 920  CEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE--- 975
            CE+   P    +W K G E+ ES    ++    +  L +   Q+ D GEY C+  +E   
Sbjct: 4483 CEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGS 4542

Query: 976  -SASFTVTVTEP----------PVRIIYPRDEVTLIAV 1002
             S + T+TVT P          P R   P++EV L +V
Sbjct: 4543 VSCTATLTVTVPGGEKKVRKLLPERKPEPKEEVVLKSV 4580



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 34/119 (28%), Positives = 55/119 (46%), Gaps = 9/119 (7%)

Query: 7     DQGSPPCFLRFPR---PVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD 63
             D+  PP     P+    + V +G   ++   + G+P P + W KG Q+L+ + RL   + 
Sbjct: 16164 DEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKST 16223

Query: 64    GAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
                  L +  A+  D+G Y+ +A+N AGE      V VL+ P       P E P+   G
Sbjct: 16224 DFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG------PPEGPVVISG 16276



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 28/92 (30%), Positives = 48/92 (52%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
           +PP F++  + + V  G++  L+  V G P PVV + + G ++ +S       +G  + L
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSL 161

Query: 70  LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
           L+  A P D+G Y   A N+ G A + A + V
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 195/938 (20%), Positives = 327/938 (34%), Gaps = 198/938 (21%)

Query: 713  SPVHI-LSPQDRVS----LTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKM 766
            +PV I ++P   VS    +T    E V L C +S    P  TWY++  ++E S    +  
Sbjct: 888  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 767  DGRKHRLILPEA-------------------------KVQDSGEFECRTEGVSAFFGVT- 800
                 RL++ EA                          VQ S EFE  T  V+  F    
Sbjct: 948  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1007

Query: 801  ---VQDPPVHIVD---------PREHVFVHAITSECV---------MLACEVDREDAP-V 838
               V+   V + D         P E    + IT   V         +  C+V     P V
Sbjct: 1008 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV 1067

Query: 839  RWYKDGQEVEESDF--VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI---- 892
             W K G  +       V    +    +LV+  T   D GE+  V  ++    + +     
Sbjct: 1068 YWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLE 1127

Query: 893  -----------------TDVSSWIVYPS------GKVYVAAVR---LERVVLTCELCRPW 926
                             T V++++  P       G VY    +    E+ ++  ++ +  
Sbjct: 1128 EADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDT 1187

Query: 927  AEVR-WTKDGEEVVESPALLLQKEDTVRRLVLPAVQL-EDSGEYLCEIDDESASFTVTVT 984
              VR + +D E  + S    L KE   R +     +L E+ GE    +D   +    +  
Sbjct: 1188 VVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGF 1247

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLE--RDG 1041
            +  ++     + +         V   C++S    P + WYKDG  ++  E   ++  +DG
Sbjct: 1248 DSRIKNYRILEGMG--------VTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1299

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             R  L +P   PED G +   A +             +  V PAA       GAP  +  
Sbjct: 1300 -RASLRIPVVLPEDEGIYTAFASNIKG----NAICSGKLYVEPAA-----PLGAPTYIPT 1349

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
               V+   S          +  S A    A      ++     P    E   E++ E + 
Sbjct: 1350 LEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERL- 1408

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV---VWSHNGRP-VQEGE 1217
            +  +    PV F  LE   +              +L   G P+    W H+G+  V +  
Sbjct: 1409 YKPVFVLKPVSFKCLEGQTARF------------DLKVVGRPMPETFWFHDGQQIVNDYT 1456

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYT--CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
               +  E   + L I  A P+ +G +T   Q+ A   + S+  TV+  E  V+ +  E  
Sbjct: 1457 HKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKL 1516

Query: 1276 QTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA--SQGRVQLEQAGARQVLRVQGAR 1332
            +  V    G  LE+ V  +G P   + W K+ + +      ++++E       L++    
Sbjct: 1517 K-NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTV 1575

Query: 1333 SGDAGEY----LCDAPQDSRIFLVSVE-----------------------------EPLL 1359
            S D+  Y    +  A +D+    V+VE                             EPL 
Sbjct: 1576 SQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLH 1635

Query: 1360 VKLVSE---------------------LTPLTVHEGDDATFRCEVSP---PDADVTWLRN 1395
            ++   E                     LT L +     A F C ++P   P   V WL +
Sbjct: 1636 LRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHD 1695

Query: 1396 GAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLF 1451
            G  +    ++ M        L        D+G +T RA    G+  TSA L V++ + L 
Sbjct: 1696 GKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSL- 1754

Query: 1452 LRRLQDVRAEEGQDVCLEV-ETGRVGAAGAVRWVRGGQ 1488
               +++ +  EG+     + E  R+   GA+  V   Q
Sbjct: 1755 ---VEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQ 1789



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 67/309 (21%), Positives = 111/309 (35%), Gaps = 55/309 (17%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA----------EDGP 188
            +L G  V   C+  G P P + W KDG  +          LQ GRA          ++G 
Sbjct: 1256 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1315

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ----PPESPPADPDEAPAPV 244
              + A  I    +    +YV  A           L  V +     P S    P       
Sbjct: 1316 YTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR 1375

Query: 245  VEPLKCAPK----------------------------------TFWVNEGKHAKFRCYVM 270
            + P + +P                                   +F   EG+ A+F   V+
Sbjct: 1376 MSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVV 1435

Query: 271  GKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLS 330
            G+P PE  W  +G+ ++ D    +    DG   L ++     D G +   A+N AG++  
Sbjct: 1436 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1495

Query: 331  AVQLHVK----EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRK 385
            +V L V+    + +  F   L++V  +E     ++ +   +  P   W +    ++P  K
Sbjct: 1496 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVP-HK 1554

Query: 386  YEQIE-EGT 393
            Y +I  EGT
Sbjct: 1555 YPKIRIEGT 1563



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 1/93 (1%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            +++++G    +  VV G P P  VW K   +L   +R+     G +  L++  AL  D G
Sbjct: 8742 IQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELD-KDRVVIDNVGTKSELIIKDALRKDHG 8800

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
             YV  A N+ G  +AAA V V + P    +L+P
Sbjct: 8801 RYVITATNSCGSKFAAARVEVFDVPGPVLDLKP 8833



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 1/105 (0%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             S +    P F+  PR   +  G      C + GEP P + W K    ++ S  +S     
Sbjct: 26755 SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR 26814

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP 109
               + L +  A  +D+G Y  +A+N  G+  A A++ VL P   +P
Sbjct: 26815 NVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL-PLVEEP 26858



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 45/157 (28%), Positives = 63/157 (40%), Gaps = 16/157 (10%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + V + +GA   L   V G PPPV+ W K G  LA+  R       +   L++      D
Sbjct: 23082 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYD 23139

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS-------PGSGEGAPV-- 129
             AG Y   A N +G+  A   V V + P   P ++  E    S       P    GAPV  
Sbjct: 23140 AGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNN 23199

Query: 130   FLTGPRSQWVLRGAEVVLTC-----RAGGLPEPTLYW 161
             ++   R   +     V   C     R  GL E T+Y+
Sbjct: 23200 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYY 23236



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 13/178 (7%)

Query: 1640 VTEGDTATFECELSQ-ALADVTWEKDGNALTPS--PRLRLQALGTRRLLQLRRCGPSDAG 1696
            V EG TATFE  +S   + +V+W +DG  ++ S  P +++     R  L +     +++G
Sbjct: 17   VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76

Query: 1697 TYSCAV--GTARA-GPVRLTVRERTVA--VLSELRSVSAREGDGATFECTVSEVET-TGR 1750
             YS     G+ +A     L V+  T     +  L+S++ R+G     +  V+ + T   +
Sbjct: 77   RYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVK 136

Query: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVE 1804
            +   G  ++     +I QEG  + L+++E   ED+G     A    G A S A L V+
Sbjct: 137  FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 4/97 (4%)

Query: 11    PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
             PP F        V++G + ++    +G P P V W K    L  + R++  A+  E+  L
Sbjct: 15775 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN--AESTENNSL 15832

Query: 71    LTA--ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             LT   A   D G YV +  N+AGEA     V VL+ P
Sbjct: 15833 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15869



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 58/264 (21%), Positives = 108/264 (40%), Gaps = 22/264 (8%)

Query: 1631  IVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRR 1689
             IV G  D  V+    A F  + + +      W KDG A+T   + +L        L++ +
Sbjct: 26482 IVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHK 26541

Query: 1690  CGPSDAGTYSCAVGTARAGPVRLTVRERTVAVL-SELRSVSAREGDGATFECTVSEVETT 1748
                SD+G Y+C V  + AG V  + +    A+  +E + VS ++    T E T  + +  
Sbjct: 26542 TDTSDSGLYTCTVKNS-AGSVSSSCKLTIKAIKDTEAQKVSTQK----TSEIT-PQKKAV 26595

Query: 1749  GRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE--DAGEVRFQAGPAQSLALLEVEAL 1806
              + E+  + LR    +++ +   +  L L E  ++   + EV+  A  +   +++  E  
Sbjct: 26596 VQEEISQKALR-SEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEIT 26654

Query: 1807  PLQMCRHPPR----------EKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEM 1856
                      R          + ++  G+R VL+  ++     V W+  G EL   ++Y  
Sbjct: 26655 KTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDVKWVLNGVELTNSEEYRY 26713

Query: 1857  RSHGPTHSLVIHDVRPEDQGTYCC 1880
                G   +L I      D+G   C
Sbjct: 26714 GVSGSDQTLTIKQASHRDEGILTC 26737



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 180/863 (20%), Positives = 317/863 (36%), Gaps = 125/863 (14%)

Query: 228   QPPESPPADP--DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
             +P ES  A    DE   P +        T  V+ G+  K    + GKP P I+W  +G  
Sbjct: 16152 EPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWI-KGDQ 16210

Query: 286   LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV--------- 336
              L +  RL  +  D    L V      D G Y+  A+N AG+    V + V         
Sbjct: 16211 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16270

Query: 337   ---------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYE 387
                      ++  L +  PLQD  G    I  +  +   SR+       + + L C+  +
Sbjct: 16271 PVVISGVTAEKCTLAWKPPLQD--GGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16328

Query: 388   QIE--EGTVRRLIIHRLKADDD---------GIYLCEMRGRVRTVANVTVKGPILKRLPR 436
              +E  E T R + +++    +            ++     +   V  VT    I+     
Sbjct: 16329 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVW--- 16385

Query: 437   KLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHALVLPGVTRED---- 491
             +    +G + +L     +   EG RW+R  + L        G +   V   +   D    
Sbjct: 16386 ERPASDGGSEILGYVLEKRDKEGIRWTRCHKRL-------IGELRLRVTGLIENHDYEFR 16438

Query: 492   -AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP--EPAPETP 548
              + E    L      +  +  C     PGPP   ++    +++V L+W  P  +   E  
Sbjct: 16439 VSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQ 16498

Query: 549   FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHG 608
               Y +E+ +V   +W  C          +  + +  + +Y FRIC ++  G   H    G
Sbjct: 16499 G-YIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPG 16557

Query: 609   SAHLVPTARLVAGLEDVQV----YDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
                ++   +L A   D+ +         A  SL L   I+G       E+K  + +G++ 
Sbjct: 16558 P--IIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGR---PTPEVKWGKVDGEIR 16612

Query: 665   PGALRYRIEQKGLQHRLILHAVKHQDSG--ALVGFSCPGVQDSAALTIQ--ESPVHILSP 720
               A+   I+       L+L  V   DSG   L   +  G + SA +T++  ++P    SP
Sbjct: 16613 DAAI---IDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTK-SAFVTVRVLDTP----SP 16664

Query: 721   QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAK 779
                + +T  T + V +T E   +D        G K++    +V K +  RK    +    
Sbjct: 16665 PVNLKVTEITKDSVSITWEPPLLD-------GGSKIK--NYIVEKREATRKSYAAVVTNC 16715

Query: 780   VQDSGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDRE 834
              ++S + +   EG S +F VT ++      P    DP +   V     +  +   +V R 
Sbjct: 16716 HKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGK--ITVDDVTRN 16773

Query: 835   DAPVRWYK----DGQEVEESDFVVLENEGPH----------RRLVLPATQPSDGGE--FQ 878
                + W K     G ++ +    ++E +  H          + L    T  + G E  F+
Sbjct: 16774 SVSLSWTKPEHDGGSKIIQ---YIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFR 16830

Query: 879   CVAGDE--------CAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVR 930
              VA +E         A   V    V    V P+   Y   V  +  +      RP   + 
Sbjct: 16831 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 16890

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY----LCEIDDESASFTVTVTEP 986
             WTKDG  + ++  + +     +  L +     +D G+Y       +  ++AS  +   + 
Sbjct: 16891 WTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 16950

Query: 987   PVRIIYPRDEVTLIAVTLECVVL 1009
             P     P+  V    V+ E + L
Sbjct: 16951 PDP---PKGPVKFDDVSAESITL 16970



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 44/198 (22%), Positives = 77/198 (38%), Gaps = 24/198 (12%)

Query: 1100  ELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHE 1158
             +L C++       ++WY+ G E+  S   ++ ++G T TLT+   + ED G Y C     
Sbjct: 24179 QLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC----- 24233

Query: 1159  AITFNVILAEPPVQFLALETTPSPLCVAPGEPV----------VLSCELSRAGAPV---V 1205
              I  N +        L L+ TP      PG P+           L   +   G PV    
Sbjct: 24234 -IATNEVGEVETSSKLLLQATPQ---FHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 24289

Query: 1206  WSHNGRPVQEGEGLEL-HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
             W H  + +Q  E + + + E    ++        HAG Y  Q     G       V++ +
Sbjct: 24290 WFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 24349

Query: 1265  PPVRVVAPEAAQTRVRST 1282
              P +   P   +  ++++
Sbjct: 24350 KPDKPTGPIVIEALLKNS 24367



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 40/149 (26%), Positives = 68/149 (45%), Gaps = 13/149 (8%)

Query: 925  PWAEVRWTKDGEEVVES--PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVT 982
            P  EV W +DG+ +  S  P + +   D   +L +PAV   +SG Y  +  + S   T T
Sbjct: 33   PVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATST 92

Query: 983  V-------TEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEA 1034
                    T PP   +     +T+   +   V L   ++    PV ++Y+DG E++ S  
Sbjct: 93   AELLVKAETAPP-NFVQRLQSMTVRQGSQ--VRLQVRVTGIPTPVVKFYRDGAEIQSSLD 149

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
              + ++G    L++  A PED G +  +A
Sbjct: 150  FQISQEGDLYSLLIAEAYPEDSGTYSVNA 178



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 75/330 (22%), Positives = 128/330 (38%), Gaps = 32/330 (9%)

Query: 516  SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIE-KAG 573
            SPP PP+   +    +  + + WKPPE    +P I Y +E   VG+E W++  S   K  
Sbjct: 7911 SPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDL 7970

Query: 574  AVEVPGDCVPSEGDYRFRICTVSGHGRS-PHVVFHGSAHLVPTARLVAGLE--DVQVYDG 630
              +V    VP + +Y  R+  V+  G S P  +        P  +    LE  D+ V +G
Sbjct: 7971 KFKVEEGVVPDK-EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEG 8029

Query: 631  EDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKH 688
            E     +    +   T  W  +G+E+K+++          R  ++   +   L +     
Sbjct: 8030 EKLSIPVPFRAVPVPTVSWHKDGKEVKASD----------RLTMKNDHISAHLEVPKSVR 8079

Query: 689  QDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD--FP 746
             D+G +   +      SA  +I    + +  P   +  +  T     LT E    D   P
Sbjct: 8080 ADAG-IYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTP 8138

Query: 747  ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFG-------- 798
               Y   ++       +  M G +++L      +  +GE+  R + V+   G        
Sbjct: 8139 ILHYVLERREAGRRTYIPVMSG-ENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8197

Query: 799  -VTVQDPPVHIVDPREHVFVHAITSECVML 827
             V  QDP     DP   V VH  T+E + +
Sbjct: 8198 PVIAQDPK-QPPDPPVDVEVHNPTAEAMTI 8226



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 40/81 (49%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G   +++  VLG P P V W+KG Q L  ++R++F        L +   + +D+G Y  
Sbjct: 14707 AGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPL 14766

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
              ARN  GE      + V + P
Sbjct: 14767 TARNIVGEVGDVITIQVHDIP 14787



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 127/603 (21%), Positives = 215/603 (35%), Gaps = 98/603 (16%)

Query: 37    GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
             G P   V W K GQ L  + R++  +      L +  A   D G Y     N+AG     
Sbjct: 19048 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 19107

Query: 97    AAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQWVLRGAEVVLTCRAGGLP 155
               + VL+ P     ++  E    S       P +  G + S +++   E   T       
Sbjct: 19108 ITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTT------ 19161

Query: 156   EPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVY---VCHAR 212
                  W     A+                     A  +++I+  RL     Y   VC A 
Sbjct: 19162 -----WHIVSQAV---------------------ARTSIKIV--RLTTGSEYQFRVC-AE 19192

Query: 213   NAHG---HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFW---VNEGKHAKFR 266
             N +G   ++++ A+  V + P SPP  P      VV   K      W   VN+G      
Sbjct: 19193 NRYGKSSYSESSAV--VAEYPFSPPGPP--GTPKVVHATKSTMLVTWQVPVNDGGSRVIG 19248

Query: 267   CYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA------ 320
              ++  K    I W    + L+ D + +     D G + +         G+  C+      
Sbjct: 19249 YHLEYKERSSILWSKANKILIADTQ-MKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPV 19307

Query: 321   -ARNSA---GQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRE 376
              AR+     GQ      +  K   L++++P  D   +  G  V   ++P           
Sbjct: 19308 PARDPCDPPGQP-EVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELP----------- 19355

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-GPILKR-- 433
             D R L C  Y  I+E       +  L  D    +    R    +V+  +   GPI+ +  
Sbjct: 19356 DGRWLKCN-YTNIQETYFE---VTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDD 19411

Query: 434   --LPRKLDVLEGENAVLL----VETLEAGVEGR------WSRDGEELPVICQS---SSGH 478
                PR +  ++  + +++    V  + A + GR      W++DG E+    ++   S+ +
Sbjct: 19412 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN 19471

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLT 537
                L +    R D G+   +L N   T  + V C     PGPP       G       L+
Sbjct: 19472 HTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 19531

Query: 538   W-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS 596
             W +P E        Y +E++E     W  C    +  + +V    +    +Y FR+  V+
Sbjct: 19532 WGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTK--LLKGNEYIFRVTGVN 19589

Query: 597   GHG 599
              +G
Sbjct: 19590 KYG 19592



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 24/85 (28%), Positives = 43/85 (50%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             V + +G++  L   V G+P P ++W KG ++L   E++S    G     ++     +D+G
Sbjct: 22685 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSG 22744

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y    +NA+G    +  V VL+ P
Sbjct: 22745 KYTLTVKNASGTKAVSVMVKVLDSP 22769



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 87/433 (20%), Positives = 168/433 (38%), Gaps = 45/433 (10%)

Query: 516   SPPGPPILA-EMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAG 573
             +PP PP    E+    K++V L+W +P +        Y +ER+E  ++ W++    +   
Sbjct: 23955 NPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 24014

Query: 574   AVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLE--DVQVYDGE 631
              +      VP + +Y+FRI   +  G S            P +  V   +  D     GE
Sbjct: 24015 TMYTVTGLVP-DAEYQFRIIAQNDVGLS---------ETSPASEPVVCKDPFDKPSQPGE 24064

Query: 632   DAVFSLDLSTII--------QGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLIL 683
               + S+   ++          G   + G  ++  +        + + RI+ K      +L
Sbjct: 24065 LEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLL 24124

Query: 684   HAVKHQD---SGALVGFSCP---GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
              A +++    +    G S P    +     LT  E+P      +D   +T    E   L+
Sbjct: 24125 EATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD---VTTKLGEAAQLS 24181

Query: 738   CELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC----RTEG 792
             C++     P   WY+ G+++ +S    +  DGR H L +   + +D G + C        
Sbjct: 24182 CQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGE 24241

Query: 793   VSAFFGVTVQ-DPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESD 851
             V     + +Q  P  H   P +  +  A+ S   +    + R    + W+   + ++ S+
Sbjct: 24242 VETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSE 24301

Query: 852   FVVLENEGPHRRLVLPATQ-PSDGGEFQC----VAGDECAYFTVTITDVSSWIVYPSGKV 906
              + +EN   +  LV+   Q  +  G+++     V G   A   V I D       P+G +
Sbjct: 24302 NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPD---KPTGPI 24358

Query: 907   YVAAVRLERVVLT 919
              + A+     V++
Sbjct: 24359 VIEALLKNSAVIS 24371



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 42/188 (22%), Positives = 74/188 (39%), Gaps = 10/188 (5%)

Query: 1638  LEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             + + EG     +  ++ A  DV W  +G  LT S   R    G+ + L +++    D G 
Sbjct: 26676 MSINEGQRLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGI 26734

Query: 1698  YSCAVGTARAGPVR----LTVRER---TVAVLSELRSVSAREGDGATFECTVS-EVETTG 1749
              +C +   + G V+    LT+ +      A +S+ RS +  EG    F C +S E     
Sbjct: 26735 LTC-ISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEI 26793

Query: 1750  RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
              W     P+   + V I +    + L +      D+G+   +A   +         + L 
Sbjct: 26794 EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP 26853

Query: 1810  MCRHPPRE 1817
             +   P RE
Sbjct: 26854 LVEEPSRE 26861



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 2/100 (2%)

Query: 8    QGSPPCFL--RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA 65
            Q +P  FL  +    + V +G + EL   V G+P P + W K    L   +R++      
Sbjct: 7313 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPK 7372

Query: 66   EHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
            +  + +  +  +D G Y+  A N  G A A   V VL+ P
Sbjct: 7373 KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP 7412



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/147 (23%), Positives = 67/147 (45%), Gaps = 6/147 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DG+ L    +   SSS  + +L +   ++ED G     + NS  +  + +  +    
Sbjct: 19056 WRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDR 19115

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP    + +   +++ ++W PPE         Y +E++E  S  W          +++
Sbjct: 19116 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19175

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH 603
             +      SE  Y+FR+C  + +G+S +
Sbjct: 19176 IVRLTTGSE--YQFRVCAENRYGKSSY 19200



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 60/268 (22%), Positives = 101/268 (37%), Gaps = 48/268 (17%)

Query: 1300  VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQD-------SRIFLV 1352
             V WY    +L +  + ++       +L V+     D G Y C    D       + +F+ 
Sbjct: 25228 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 25287

Query: 1353  SVEEPL-------------------LVKLVSELT-PL---TVHEGDDATFRCEVSP-PDA 1388
              V E                     L++   E T PL   T + G++  F   ++  P+ 
Sbjct: 25288 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 25347

Query: 1389  DVTWLRNGAVVTPGPQVEMAQNGSSR---ILTLRGCQLGDAGTVTLRA----GSTATSAR 1441
              VTW ++G  + PG   +     S +    LT+      D    T+ A    G  +  A+
Sbjct: 25348 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 25407

Query: 1442  L----HVRETEL----LFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHD 1493
             L    H   T+     +F R L +   +EGQ VC E+    +     ++W + GQPL   
Sbjct: 25408 LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGI-PPPTLKWEKDGQPLSLG 25466

Query: 1494  SRLSMAQDG-HIHRLFIHGVILADQGTY 1520
               + +  +G   + L I   +  D G Y
Sbjct: 25467 PNIEIIHEGLDYYALHIRDTLPEDTGYY 25494



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 19/187 (10%)

Query: 1725 LRSVSAREGDGATFECTVS-----EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
            L+SV   EG  ATFE  +S     EV      ++      PG ++    +G+  + + + 
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDGRAKLTIPAV 70

Query: 1780 LRAEDAGEVRFQA----GPAQSLA--LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS 1833
             +A ++G    +A    G A S A  L++ E  P    +   +  TV  G +  L+V V+
Sbjct: 71   TKA-NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL-QSMTVRQGSQVRLQVRVT 128

Query: 1834 RSGGHVC-WLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTH 1888
                 V  + R+GAE+     +++   G  +SL+I +  PED GTY   A    G+ ++ 
Sbjct: 129  GIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATST 188

Query: 1889 TRLLVEG 1895
              LLV+G
Sbjct: 189  AELLVQG 195



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 5/88 (5%)

Query: 1812  RHPPREKTVLVGRRAVLEVT-VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDV 1870
             R   ++ T  +G  A L    V R    + W R G EL    KY+M S G TH+L +   
Sbjct: 24164 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTE 24223

Query: 1871  RPEDQGTYCC----QAGQDSTHTRLLVE 1894
               ED+G Y C    + G+  T ++LL++
Sbjct: 24224 EQEDEGVYTCIATNEVGEVETSSKLLLQ 24251



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 25/93 (26%), Positives = 44/93 (47%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
            V+ G +  +       P P V W K G+++ AS+RL+   D     L +  ++  DAG+Y
Sbjct: 8026 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 8085

Query: 83   VCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
                 N  G A A+  V V+  P    +++ ++
Sbjct: 8086 TITLENKLGSATASINVKVIGLPGPCKDIKASD 8118



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 26/85 (30%), Positives = 40/85 (47%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             + V  G    +   V G P P + W K G+ L   +R+    D     L +  A+  D G
Sbjct: 11546 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 11605

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y+  A+N++G A  +A V VL+ P
Sbjct: 11606 KYIISAKNSSGHAQGSAIVNVLDRP 11630



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 33/101 (32%), Positives = 42/101 (41%), Gaps = 2/101 (1%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVW--EKGGQQLAASERLSFPADG 64
             D   P   L+    + V +G    L+  V G+P P V W  +K    L  S R+      
Sbjct: 11825 DLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA 11884

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                   LT A  +D G YV  A N AG   A A V VL+ P
Sbjct: 11885 DSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKP 11925



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 40/149 (26%), Positives = 63/149 (42%), Gaps = 8/149 (5%)

Query: 461   WSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             WS+ G+++    +   +S+     L +   TR+DAGE T +  N   T +  VK      
Sbjct: 14041 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDV 14100

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-IYRLERQEVGSEDW-IQCFSIEKAGAV 575
             PGPP   E+         LTW PP     +P   Y LE++E     W +    I+    V
Sbjct: 14101 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHV 14160

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                   +    +Y FR+  V+ +G+   V
Sbjct: 14161 ATK---LIQGNEYIFRVSAVNHYGKGEPV 14186



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 248   LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKV 306
             ++  P    ++EGK     C   G+P PE+ W   GR +   ++ R    + D    L +
Sbjct: 26959 IEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLII 27018

Query: 307   LYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             +  Q +D GLY  +  N  G   + V +H++
Sbjct: 27019 MDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 27049



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 83/382 (21%), Positives = 142/382 (37%), Gaps = 51/382 (13%)

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
            LV+    R D G  T  L N   T    +     + P  P   +     K++V LTW+PP
Sbjct: 7080 LVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPP 7139

Query: 542  EPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS--GH 598
            +    +P   Y +E++EV  + W +           VP D V  + +Y F++C  +  G 
Sbjct: 7140 DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP-DLVQGK-EYLFKVCARNKCGP 7197

Query: 599  GRSPHV---VFHGSAHLVP-----------TARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
            G   +V   V   +   VP           TA  +    D    DG   +    +    +
Sbjct: 7198 GEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPR 7257

Query: 645  GT--WFLNGEELKSNEPE--GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP 700
            G+  W   GE +   + E  G  E     YR++    Q                 G S P
Sbjct: 7258 GSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQ-----------------GASKP 7300

Query: 701  G--VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVE 757
                ++  A+  QE+P   L  +    LT     ++ L   ++    P  TW K    ++
Sbjct: 7301 SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILK 7360

Query: 758  ESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDPPVHIVDPRE 813
            + + + ++   +K  + + ++K  D+G +      V    +A   V V D P     P  
Sbjct: 7361 QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP----GPPA 7416

Query: 814  HVFVHAITSECVMLACEVDRED 835
               +  +T+E  +L     R+D
Sbjct: 7417 AFDITDVTNESCLLTWNPPRDD 7438



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 38/163 (23%), Positives = 62/163 (38%), Gaps = 16/163 (9%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
             +Q  PP  L  P  + + +G +  ++  V G+P P   W+KG  ++  S  L+     + 
Sbjct: 12523 EQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS 12581

Query: 67    HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS----------DPELQPAER 116
               L++      D+G Y   A N++G       V V++ P            D +      
Sbjct: 12582 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSW 12641

Query: 117   PLPSPGSGEGAPVFLTG----PRSQWVLRGAEVVLT-CRAGGL 154
              +P    G     ++       R  WV   A V  T CR G L
Sbjct: 12642 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKL 12684



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 117/570 (20%), Positives = 217/570 (38%), Gaps = 77/570 (13%)

Query: 345   RPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLK 403
             + ++DV  +    A L C++    +P   W+R  + L+  RKY+   +G    L +   +
Sbjct: 24165 KEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEE 24224

Query: 404   ADDDGIYLCEMRGRVRTVANVTVKGPILKRLPR---------KLDVLEGENAVLLVETLE 454
              +D+G+Y C     V  V   T    +L+  P+         K     G    L V  + 
Sbjct: 24225 QEDEGVYTCIATNEVGEVE--TSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIG 24282

Query: 455   AGVEGRWSRDGEEL----PVICQSSSGHMHALVLPGVTRED-AGEVTFSLGNSRTTTL-- 507
               V       G++L      I   ++ H   LV+  V R+  AG+    L N   T    
Sbjct: 24283 RPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAI 24342

Query: 508   --LRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE-----TPFIYRLERQEVGS 560
               + ++     P GP ++  + K   N+ +++WKP  PA +     T ++      + G+
Sbjct: 24343 LDVEIQDKPDKPTGPIVIEALLK---NSAVISWKP--PADDGGSWITNYVVEKCEAKEGA 24397

Query: 561   EDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP-----HVVFHGSAHLVPT 615
             E W    S        +    +     Y FR+   +  G S       VV   S    P 
Sbjct: 24398 E-WQLVSSAISVTTCRIVN--LTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG 24454

Query: 616   ARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT----WFLNGEELKSNE----PEGQVEPGA 667
             A    G   +     +  V +        G     ++L   E K N+       ++    
Sbjct: 24455 A---PGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETV 24511

Query: 668   LRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSP---QDRV 724
                +   +GL++      VK ++ G    +S    + S  +T  +S V I +P   ++  
Sbjct: 24512 FSVKNLIEGLEYEF---RVKCENLGGESEWS----EISEPIT-PKSDVPIQAPHFKEELR 24563

Query: 725   SLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELL--VVKMDGRKHRLILPEAKVQ 781
             +L         L C+++    P   WY+ G+++    L   + +  G  H+LI+      
Sbjct: 24564 NLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDD 24623

Query: 782   DSGEFECRTEG----VSAFFGVTVQDPP-VHIVDPREHV-FVHAITSECVMLACEVDRED 835
             D+  ++ R       VS    + V+ P  +H+    E +  VHA+  E V +      + 
Sbjct: 24624 DATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKP 24683

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLV 865
              PV  ++ GQ+       +++N G ++ +V
Sbjct: 24684 DPVITWQKGQD-------LIDNNGHYQVIV 24706



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 60/287 (20%), Positives = 101/287 (35%), Gaps = 49/287 (17%)

Query: 1461  EEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
             EEG  V    +      +  V W  G + L +  +  +  +  +  L++  +   D GTY
Sbjct: 25208 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 25267

Query: 1521  GCESHHD------------------------RTLARLSVRPRQLRVLRPLEDVTISEGGS 1556
              C+  +D                        RT+ ++  R   +R+L    + T+     
Sbjct: 25268 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 25327

Query: 1557  ATFQLELSQEGVT--------GEWARGGVQLYPG---PKCHIHSDGHRHRLVLNGLGLAD 1605
               +  E  + GVT          W + G ++ PG    K    SD   ++L +N +   D
Sbjct: 25328 TAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDD 25387

Query: 1606  SGCVSFTA------DSLRCAARLIVREVPVTIVRGP------HDLEVTEGDTATFECELS 1653
                 +  A      DS +    + +   P      P       + E  EG +  FE  +S
Sbjct: 25388 DAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVS 25447

Query: 1654  Q-ALADVTWEKDGNALTPSPRLRLQALG-TRRLLQLRRCGPSDAGTY 1698
                   + WEKDG  L+  P + +   G     L +R   P D G Y
Sbjct: 25448 GIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 25494



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 6/107 (5%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             +F   + V +G    L+  V G+P P + W +G +++  S R        +  L++  A+
Sbjct: 17258 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAI 17317

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
               D G Y+ RA N AG       V VL+ P       P E P+   G
Sbjct: 17318 RIDGGQYILRASNVAGSKSFPVNVKVLDRPG------PPEGPVQVTG 17358



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 17/180 (9%)

Query: 1284 GGDLELVVHLSG-PGGPVRWYKDGERLASQGR--VQLEQAGARQVLRVQGARSGDAGEYL 1340
            G       H+SG P   V W++DG+ +++     VQ+  +  R  L +      ++G Y 
Sbjct: 20   GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79

Query: 1341 CDAPQDSRIFLVSVEEPLLVK-------LVSELTPLTVHEGDDATFRCEVSP-PDADVTW 1392
              A   S     + E  LLVK        V  L  +TV +G     +  V+  P   V +
Sbjct: 80   LKATNGSGQATSTAE--LLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKF 137

Query: 1393 LRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETE 1448
             R+GA +      +++Q G    L +      D+GT ++ A    G   ++A L V+  E
Sbjct: 138  YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEE 197



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 29/110 (26%), Positives = 43/110 (39%), Gaps = 2/110 (1%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P   R   P+ V  G  A+  C +   P     W K G+++  S++ S  +      L +
Sbjct: 4462 PVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEI 4521

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP--ELQPAERPLP 119
                  D G Y C+A N  G     A +TV  P       +L P  +P P
Sbjct: 4522 LRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPERKPEP 4571



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 23/75 (30%), Positives = 35/75 (46%)

Query: 31    LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAA 90
             LK  + G+P P V W+KG   LA   R+S  +      L++     +DAG Y    +N A
Sbjct: 13630 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 13689

Query: 91    GEAYAAAAVTVLEPP 105
             G      ++ V+  P
Sbjct: 13690 GTKEGTISIKVVGKP 13704



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 6/104 (5%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   V + +G    L+  V G PPP + W K G++L  + +L          L+   +
Sbjct: 15093 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDS 15152

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL 118
                D+G Y   A N  G A     V VL+ P       P E PL
Sbjct: 15153 TRRDSGAYTLTATNPGGFAKHIFNVKVLDRPG------PPEGPL 15190



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 1/89 (1%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G + ++     G PPP V W K  + L +  R S     +   L +      D G Y+ 
Sbjct: 20913 AGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYIL 20972

Query: 85    RARNAAGEAYAA-AAVTVLEPPASDPELQ 112
                N  GE  ++  +V VL+ PA+  +LQ
Sbjct: 20973 TIENGVGEPKSSTVSVKVLDTPAACQKLQ 21001



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 50/213 (23%), Positives = 75/213 (35%), Gaps = 40/213 (18%)

Query: 1721  VLSELRSVSAREGDGATFECTVSEVE--TTGRWELGGRPLRPGARVRIRQEGKKHILVLS 1778
             V  ++      EG    + C +   +  T   W  G R L    +  I  E    IL + 
Sbjct: 25198 VSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVK 25257

Query: 1779  ELRAEDAGEVRFQA----GPAQSLALLEVEAL--------------------PLQMCRHP 1814
             ++   D G  R +     G   S A L V+ +                     +++   P
Sbjct: 25258 DITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERP 25317

Query: 1815  PR------EKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGD---KYEMRSHGPTHS 1864
             P        KT  VG      VT++     HV W + G ++ PGD   KY   S    + 
Sbjct: 25318 PEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQ 25377

Query: 1865  LVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
             L I+ V  +D   Y   A    G+DS   +L V
Sbjct: 25378 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/91 (30%), Positives = 37/91 (40%), Gaps = 1/91 (1%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE-HGLL 70
             P F R         G     +  V G PPP + WEK GQ L+    +    +G + + L 
Sbjct: 25423 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25482

Query: 71    LTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
             +   LP D G Y   A N AG     A + V
Sbjct: 25483 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 25513



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 32/124 (25%), Positives = 53/124 (42%), Gaps = 3/124 (2%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             L +     ED G  + ++ N   +  + VK +    PGPP   E+ +  K++  LTWK P
Sbjct: 10902 LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEP 10961

Query: 542   -EPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
              +        Y +ER++V S  W    +  K  +       +     Y FR+   + +GR
Sbjct: 10962 LDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH--LNEGNQYLFRVAAENQYGR 11019

Query: 601   SPHV 604
              P V
Sbjct: 11020 GPFV 11023



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 8/90 (8%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
            PPGPP   E+    K+++ L WKPP     +P   Y +E QE G+ DW +   + +   +
Sbjct: 9332 PPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKR---VNEPDKL 9388

Query: 576  EVPGDCVPSE----GDYRFRICTVSGHGRS 601
                +CV         YRFR+  V+  G S
Sbjct: 9389 ITTCECVVPNLKELRKYRFRVKAVNEAGES 9418



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 23/83 (27%), Positives = 32/83 (38%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G       ++ G P P   W   G ++   E  +   D     L +   L  D G Y
Sbjct: 11150 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEY 11209

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  NAAG    A  +TVL+ P
Sbjct: 11210 QITVSNAAGSKTVAVHLTVLDVP 11232



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/465 (21%), Positives = 172/465 (36%), Gaps = 60/465 (12%)

Query: 1021  RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
             +W  DG E++  E   +E D     L +      D GE+     + +   TV V      
Sbjct: 11171 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 11230

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAP--AGSQVRWYKDGLEVEASDALQLGAEGPTRT- 1137
             +  P    +++    P  + +  +      GS V  Y    +    D   + + G ++T 
Sbjct: 11231 VPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTK 11290

Query: 1138  LTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALE-----TTPSPLCVAPGEPVV 1192
             L +PH Q     EYV   R E    N I   PP+           + PSP    PG+PVV
Sbjct: 11291 LKIPHLQK--GCEYVFRVRAE----NKIGVGPPLDSTPTVAKHKFSPPSP----PGKPVV 11340

Query: 1193  LSCELSRAGAPVVW----SHNGRPVQ---------EGEGLELHAEGPRRVLCIQAAGPAH 1239
                +++   A V W    S  G P+           G+ + ++ + P   L  +  G   
Sbjct: 11341 T--DITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVN-KTPIADLKFRVTGLYE 11397

Query: 1240  AGLYTCQ------SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
                Y  +      +G +  +PS S  ++   P      P   + + +S    DL     L
Sbjct: 11398 GNTYEFRVFAENLAGLSKPSPS-SDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPL 11456

Query: 1294  SGPGGPVRWY-----KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----- 1343
             S  G P+  Y     K G   A   R+  ++   +   RV G   G+   +   A     
Sbjct: 11457 SDGGSPILGYVVECQKPGT--AQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11514

Query: 1344  ---PQD--SRIFLVSVEEPLLVKL-VSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
                P++    +    +  P  V+L V+    +TV  G        V   P+ D+TW + G
Sbjct: 11515 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11574

Query: 1397  AVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSAR 1441
              V+    +V++ Q+     L ++     D G   + A +++  A+
Sbjct: 11575 KVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQ 11619



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 72/378 (19%), Positives = 127/378 (33%), Gaps = 62/378 (16%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R + V +G    +   + G P P V W K    L    R +     +   L++      D
Sbjct: 14412 RTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINL--KNRANIENTESFTLLIIPECNRYD 14469

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQ 137
              G +V    N AG+      V VL+ P     L+P +    S       P+   G R + 
Sbjct: 14470 TGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITN 14529

Query: 138   WVLRGAEV-------------------------------VLTCRAGGLPEPTLYWEK--- 163
             +++   E                                V+     G+ EPT   E    
Sbjct: 14530 YIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 14589

Query: 164   -------DGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYV-------- 208
                    D + + ++  S+     P    DG G+ +   ++ A+   S  +         
Sbjct: 14590 SEAPSPPDSLNIMDITKSTVSLAWPKPKHDG-GSKITGYVIEAQRKGSDQWTHITTVKGL 14648

Query: 209   -CHARN-AHGHAQAGALLQVHQPPESPPADP------DEAPAPVVEPLKCAPKTFWVNEG 260
              C  RN   G      ++ V+    S P +       ++   P ++      K      G
Sbjct: 14649 ECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 14708

Query: 261   KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              + K    V+G+P+P + W  +G  +L   +R+ +       +L +  C   D G Y   
Sbjct: 14709 DNIKVEIPVLGRPKPTVTWK-KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 14767

Query: 321   ARNSAGQTLSAVQLHVKE 338
             ARN  G+    + + V +
Sbjct: 14768 ARNIVGEVGDVITIQVHD 14785



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 24/83 (28%), Positives = 39/83 (46%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + +G + +++  V+G P P + W K G+ L  + R++         L +      D G Y
Sbjct: 17951 IQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKY 18010

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A N+AG A    +V VLE P
Sbjct: 18011 TVTATNSAGTATENLSVIVLEKP 18033



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 22/92 (23%), Positives = 40/92 (43%)

Query: 10    SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
             S P  +   +   V S + A+      GEP P  +W K G+ +    +     D     L
Sbjct: 26478 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFL 26537

Query: 70    LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +     +D+G+Y C  +N+AG   ++  +T+
Sbjct: 26538 EIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26569



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 52/216 (24%), Positives = 87/216 (40%), Gaps = 29/216 (13%)

Query: 727 TFTTSERVVLTCELSRVDFPA----------TWYKDGQKVEESELLVVKM---DGRKHRL 773
           TFT   + V+  E S   F A          +W++DGQ +  S L  V++   DGR  +L
Sbjct: 7   TFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA-KL 65

Query: 774 ILPEAKVQDSGEFECRTEGVS------AFFGVTVQDPPVHIVDPREHVFVHAITSECVML 827
            +P     +SG +  +    S      A   V  +  P + V   + + V   +   V L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ--VRL 123

Query: 828 ACEVDREDAPV-RWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
              V     PV ++Y+DG E++ S    +  EG    L++    P D G +   A +   
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183

Query: 887 YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL 922
             T T        +   G+  V A + + +V T ++
Sbjct: 184 RATSTAE------LLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 5/122 (4%)

Query: 219   QAGALLQVHQPPESPPADPDEAPAPVVEP---LKCAPKTFW-VNEGKHAKFRCYVMGKPE 274
             +A A   V+  P S P+DP    A  V P   L  A K+   V  G +      V GKP 
Sbjct: 12893 RAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPM 12952

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P + W  +G  L P     M   R+    L++     KD G Y   A NS+G   + ++L
Sbjct: 12953 PTVSWKKDGTLLKPAEGIKMAMQRN-LCTLELFSVNRKDSGDYTITAENSSGSKSATIKL 13011

Query: 335   HV 336
              V
Sbjct: 13012 KV 13013



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 23/87 (26%), Positives = 34/87 (39%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + + V +G   EL   + G PPP   W   G +L  SER++         L +      D
Sbjct: 23374 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRD 23433

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPP 105
              G Y    +N  G       V +L+ P
Sbjct: 23434 TGEYTLELKNVTGTTSETIKVIILDKP 23460



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 48/225 (21%), Positives = 86/225 (38%), Gaps = 25/225 (11%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G    L+C+  G P P + W + G    E+  S  + +         G +  L ++    
Sbjct: 24175 GEAAQLSCQIVGRPLPDIKWYRFGK---ELIQSRKYKMS------SDGRTHTLTVMTEEQ 24225

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGK 261
              D GVY C A N  G  +  + L +   P+  P            PLK   + ++   G 
Sbjct: 24226 EDEGVYTCIATNEVGEVETSSKLLLQATPQFHPG----------YPLK---EKYYGAVGS 24272

Query: 262   HAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR-GLYVCA 320
               +     +G+P P + W + G+ LL +   +   + +    L +   Q K   G Y   
Sbjct: 24273 TLRLHVMYIGRPVPAMTW-FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ 24331

Query: 321   ARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
               N  G   + + + +++   + T P+  +E      AV+  K P
Sbjct: 24332 LSNVFGTVDAILDVEIQDKPDKPTGPIV-IEALLKNSAVISWKPP 24375



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 2/99 (2%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             +G +G PP     P  + +  G    + C   GEP P V W  GG+++ + E+  F  + 
Sbjct: 26950 AGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIEN 27009

Query: 65    AEH--GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +    L++      D G+Y     N  G   A   + +
Sbjct: 27010 TDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27048



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 25/83 (30%), Positives = 35/83 (42%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + SG    +K +V G P P V W K G ++     +          L +  A     GVY
Sbjct: 21598 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 21657

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+NA+G A A   V V + P
Sbjct: 21658 TVEAKNASGSAKAEIKVKVQDTP 21680



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 119/577 (20%), Positives = 207/577 (35%), Gaps = 118/577 (20%)

Query: 1111 QVRWYKDGLEVEASDALQLG-AEGPTRTLTLPHAQPEDAGEYVC---ETRHEAITFNVIL 1166
            ++ WYKDG  ++  +  Q+   +    +L +P   PED G Y       +  AI    + 
Sbjct: 1275 KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY 1334

Query: 1167 AEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGP 1226
             EP     A      P  +   EPV      SR  +    S +  P++           P
Sbjct: 1335 VEPAAPLGA------PTYIPTLEPV------SRIRSLSPRSVSRSPIRMSPA----RMSP 1378

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGD 1286
             R+       PA         G        S   ++ +P V V+ P + +     T   D
Sbjct: 1379 ARM------SPARMSPARMSPGRRLEETDESQLERLYKP-VFVLKPVSFKCLEGQTARFD 1431

Query: 1287 LELVVHLSGPGGPVRWYKDGERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAP 1344
            L++V     P     W+ DG+++ +    +V +++ G + ++ V    S D+GE+   A 
Sbjct: 1432 LKVV---GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPS-DSGEWTVVAQ 1487

Query: 1345 QDSRIFLVSV-------EEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
              +    +SV       E  +    V +L  + + EG     +   +  P+ D+ WL+N 
Sbjct: 1488 NRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS 1547

Query: 1397 AVVTPG--PQVEMAQNGSSRILTLRGCQLGDA----GTVTLRAGSTATSARLHVR----- 1445
             ++ P   P++ +        L +      D+     T   +AG   T  +++V      
Sbjct: 1548 DIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAE 1607

Query: 1446 ---ETELLFLR---RLQDVRAEE--------GQDVCLE--------------------VE 1471
               E +L+  R   R +++ A E        GQ+   E                    + 
Sbjct: 1608 PEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1667

Query: 1472 TGRVGAAG-------------AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQG 1518
              R G A               V W+  G+PL   +RL M  +     L        D G
Sbjct: 1668 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSG 1727

Query: 1519 TYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE----LSQEG-VT 1569
               C + +    D T A L V+  +  V    E+  + EG     ++E    ++ EG +T
Sbjct: 1728 IITCRATNKYGTDHTSATLIVKDEKSLV----EESQLPEGRKGLQRIEELERMAHEGALT 1783

Query: 1570 G------EWARGGVQLYPGPKCHIHSDGHRHRLVLNG 1600
            G      E  +  + LYP P   +  +  R R  + G
Sbjct: 1784 GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTG 1820



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 40/139 (28%), Positives = 50/139 (35%), Gaps = 23/139 (16%)

Query: 205  GVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV----EPLKCAPKTFWVNEG 260
            G YVC A N  G     A L V +             APV+    EPL+ A        G
Sbjct: 4435 GEYVCEALNDSGKTATSAKLTVVK-----------RAAPVIKRKIEPLEVAL-------G 4476

Query: 261  KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              AKF C +   P    +W   GR +  +  +   R       L++L  Q  D G Y C 
Sbjct: 4477 HLAKFTCEIQSAPNVRFQWFKAGREIY-ESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 4535

Query: 321  ARNSAGQTLSAVQLHVKEP 339
            A N  G       L V  P
Sbjct: 4536 ASNEYGSVSCTATLTVTVP 4554



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 79/341 (23%), Positives = 128/341 (37%), Gaps = 51/341 (14%)

Query: 105   PASDPELQPAERPLPSPG----------SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGL 154
             P+SDP    A RP+  PG          S E A +  T P S         V+ C+  G 
Sbjct: 11418 PSSDPI--KACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG- 11474

Query: 155   PEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
                T  W +  +  DE+     F + PG  E   G     RI AA +   G         
Sbjct: 11475 ---TAQWNR--INKDELIRQCAFRV-PGLIE---GNEYRFRIKAANIVGEG-------EP 11518

Query: 215   HGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                A++     +  PPE             VE          V  G+  +    V G+PE
Sbjct: 11519 RELAESVIAKDILHPPE-------------VELDVTCRDVITVRVGQTIRILARVKGRPE 11565

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P+I W  EG+ L+ ++R  + +D      L++      D G Y+ +A+NS+G    +  +
Sbjct: 11566 PDITWTKEGKVLVREKRVDLIQDLP-RVELQIKEAVRADHGKYIISAKNSSGHAQGSAIV 11624

Query: 335   HVKEPRLRFTRPLQDVE----GREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
             +V    L    P Q+++     +E+     E  + N       F  + R    + +  + 
Sbjct: 11625 NV----LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVA 11680

Query: 391   EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
                 +RLI   L A+++  +      +V     +  K PIL
Sbjct: 11681 SDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPIL 11721



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 25/100 (25%), Positives = 41/100 (41%), Gaps = 1/100 (1%)

Query: 239   EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDR 298
             EA   ++ P    P+   +  GK  +   +V GKP P  +W  +G   +     L     
Sbjct: 12520 EAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKA 12578

Query: 299   DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
             D   +L +     KD G Y   A NS+G     +++ V +
Sbjct: 12579 DSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMD 12618



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 1/85 (1%)

Query: 458   EGRWSRD-GEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             E +W+RD GE L      S+     L++  V R D+G+   ++ NS  +    V      
Sbjct: 15519 EVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLD 15578

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPP 541
              PGPP   ++ +  K +V LTW PP
Sbjct: 15579 TPGPPQDLKVKEVTKTSVTLTWDPP 15603



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 34/119 (28%), Positives = 47/119 (39%), Gaps = 11/119 (9%)

Query: 231   ESPPADPDEAPAPVVEP-------LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             E   +DP     PV+         LK    T+ +  G+  K    V+G+P P I W  +G
Sbjct: 17918 EKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDG 17977

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG---QTLSAVQLHVKEP 339
              P L    R+   +     VL +      D G Y   A NSAG   + LS + L    P
Sbjct: 17978 EP-LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGP 18035



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 23/91 (25%), Positives = 42/91 (46%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             L +   V+  +G   +L+  + G+P P + W K  ++L  +  +          +L+  A
Sbjct: 20504 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDA 20563

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                ++G Y  + RNA G A A   V +L+ P
Sbjct: 20564 DRLNSGCYELKLRNAMGSASATIRVQILDKP 20594



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 21/182 (11%)

Query: 1178 TTPSPLCVAPGEPVVL------SCELSRAGAPVV---WSHNGRPVQEGE--GLELHAEGP 1226
            TT +P    P + VV+      + E   +G PV    W  +G+ +      G+++     
Sbjct: 2    TTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDG 61

Query: 1227 RRVLCIQAAGPAHAGLYTCQ----SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRST 1282
            R  L I A   A++G Y+ +    SG A     L    + A PP  V   ++   R    
Sbjct: 62   RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA-PPNFVQRLQSMTVR---- 116

Query: 1283 PGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
             G  + L V ++G P   V++Y+DG  + S    Q+ Q G    L +  A   D+G Y  
Sbjct: 117  QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176

Query: 1342 DA 1343
            +A
Sbjct: 177  NA 178



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 7/101 (6%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQL-AASERLSFPADGAEHGLLLTAALPTDAGV 81
             V +G    L+  + G+P P VVW K G++L   + R+   +   +  L++   + TD G 
Sbjct: 18347 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 18406

Query: 82    YVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             Y+ +  N  G       V VL+ P       P E PL   G
Sbjct: 18407 YILKLSNVGGTKSIPITVKVLDRPG------PPEGPLKVTG 18441



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 68/300 (22%), Positives = 118/300 (39%), Gaps = 39/300 (13%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAG 573
             SP  PP   +     + T+ L W PP     +  + Y +E+++ G+E W++C F+     
Sbjct: 21481 SPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSEC 21539

Query: 574   AVEVPGDCVPSEGD-YRFRIC------TVSGHGRSPHVVFHGSAHLVPTARLVAGLED-V 625
                V G    S GD Y FRI       T+S   +S  ++     ++ P         D +
Sbjct: 21540 QYTVTG---LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGL 21596

Query: 626   QVYDGEDAVFSLDLSTIIQG------TWFLNGEEL-KSNEPEGQVEPGALRYRIEQKGLQ 678
              +  GE    SL +  ++QG      TWF +G E+ K    E     G+    +      
Sbjct: 21597 IIKSGE----SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRD 21652

Query: 679   HRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTC 738
             HR +        SG+         +    + +Q++P  ++ P   +  T  T E++ L  
Sbjct: 21653 HRGVYTVEAKNASGS--------AKAEIKVKVQDTPGKVVGP---IRFTNITGEKMTLWW 21701

Query: 739   ELSRVD--FPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
             +    D   P T Y   +K E S L    ++ +         K+ +  E++ R   V+ F
Sbjct: 21702 DAPLNDGCAPITHYII-EKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKF 21760



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 38/150 (25%), Positives = 57/150 (38%), Gaps = 30/150 (20%)

Query: 80   GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWV 139
            G YVC A N +G+   +A +TV++  A  P ++    PL                    V
Sbjct: 4435 GEYVCEALNDSGKTATSAKLTVVKRAA--PVIKRKIEPLE-------------------V 4473

Query: 140  LRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAA 199
              G     TC     P     W K G    E+++S   +++  +         +L IL  
Sbjct: 4474 ALGHLAKFTCEIQSAPNVRFQWFKAGR---EIYESDKCSIRSSKYIS------SLEILRT 4524

Query: 200  RLPDSGVYVCHARNAHGHAQAGALLQVHQP 229
            ++ D G Y C A N +G     A L V  P
Sbjct: 4525 QVVDCGEYTCKASNEYGSVSCTATLTVTVP 4554



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 38/252 (15%)

Query: 373  WFREDQRLLPCRKY--EQIEEGTVRRLIIHRLKADDDG-------IYLCEMRGRVRTVAN 423
            W R  ++++  R+Y  ++I EG   +L +  + A  +G       + + E +       +
Sbjct: 8676 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELD 8735

Query: 424  VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGEELPV--ICQSS 475
            V+VKG I         ++ G+        + A V GR      W+++  EL    +   +
Sbjct: 8736 VSVKGGI--------QIMAGKTL-----RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDN 8782

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
             G    L++    R+D G    +  NS  +     +      PGP +  +    ++   L
Sbjct: 8783 VGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCL 8842

Query: 536  LTWKPPEP---APETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
            L W  PE    +  T FI  +ER++     W Q    E++   ++ G  +    +Y+FR+
Sbjct: 8843 LNWSDPEDDGGSEITGFI--IERKDAKMHTWRQPIETERS-KCDITG--LLEGQEYKFRV 8897

Query: 593  CTVSGHGRSPHV 604
               +  G  P V
Sbjct: 8898 IAKNKFGCGPPV 8909



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 34/112 (30%), Positives = 46/112 (41%), Gaps = 11/112 (9%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    L   V G+P P V W+K G  L  +E +          L L +    D+G Y
Sbjct: 12935 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDY 12994

Query: 83    VCRARNAAGEAYAAAAVTVLE---PPA--------SDPELQPAERPLPSPGS 123
                A N++G   A   + VL+   PPA        SD  +   E PL   GS
Sbjct: 12995 TITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGS 13046



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 22/86 (25%), Positives = 42/86 (48%), Gaps = 1/86 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP   +++   +++V L+W  P     +P I Y +E +   S++W++C   +     
Sbjct: 13216 PPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKT 13275

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
                   +  +  Y+FR+  V+  G S
Sbjct: 13276 RFEVTGLMEDTQYQFRVYAVNKIGYS 13301



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 108/551 (19%), Positives = 196/551 (35%), Gaps = 81/551 (14%)

Query: 418   VRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ--- 473
             V  +A   V  P  K L     VL GE+  + V  +        W +D   L    +   
Sbjct: 15765 VPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNA 15824

Query: 474   SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPI-LAEMFKGHKN 532
              S+ +   L +    RED G     L NS    +  +  +    PGPP    +M +   +
Sbjct: 15825 ESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTAD 15884

Query: 533   TVLLTWKPPE-PAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
             ++ L+W PP+     +   Y +E+++  +  W Q  S   A    +    + +  +Y+FR
Sbjct: 15885 SITLSWGPPKYDGGSSINNYIVEKRDTSTTTW-QIVSATVA-RTTIKACRLKTGCEYQFR 15942

Query: 592   ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
             I   + +G+S ++    +    P               G      + LS+        + 
Sbjct: 15943 IAAENRYGKSTYLNSEPTVAQYPFK-----------VPGPPGTPVVTLSS-------RDS 15984

Query: 652   EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
              E++ NEP        + Y +E+K  +   IL    ++       F   G+++      +
Sbjct: 15985 MEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFR 16042

Query: 712   ESPVHI--LSPQDRVSLTFTT---------SERVVLTCELSRVDFPATWYKDGQK----- 755
              S  +I  +    +VS  +            E +++T     + +    Y  G K     
Sbjct: 16043 VSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYI 16102

Query: 756   VEESELLVVKMDGR---------------------KHRLILPEAKVQDSGEFECRTEGVS 794
             VE+ EL     +GR                      HR          +G F   +E   
Sbjct: 16103 VEKKEL----PEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTG 16158

Query: 795   AFFGVTVQDPPVHIVDP--REHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESD 851
             A       DPP   +DP  ++ + VHA   E   +  ++  +  P ++W K  QE+  + 
Sbjct: 16159 AITARDEVDPPRISMDPKYKDTIVVHA--GESFKVDADIYGKPIPTIQWIKGDQELSNTA 16216

Query: 852   FVVLENEGPHRRLVLPATQPSDGGEF----QCVAGDECAYFTVTITDVSSWIVYPSGKVY 907
              + +++      L +      D G +    + VAG+      V + D       P G V 
Sbjct: 16217 RLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG---PPEGPVV 16273

Query: 908   VAAVRLERVVL 918
             ++ V  E+  L
Sbjct: 16274 ISGVTAEKCTL 16284



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 94/441 (21%), Positives = 167/441 (37%), Gaps = 67/441 (15%)

Query: 461   WSRDGEELP--VICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP 518
             WS+ G +L    I  ++  +   L++  V R DAG+ T    N        V    +  P
Sbjct: 23108 WSKQGIDLASRAIIDTTESYS-LLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 23166

Query: 519   GPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEV 577
             GP    ++ +  +++V +TW+ P      P   Y +E++E     +    +        +
Sbjct: 23167 GPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRI 23226

Query: 578   PGDCVPSEGD-YRFRICTVSGHG-----RSPHVVFHGSAHLVP--------TARLVAGLE 623
              G     EG  Y FR+   + +G      +   V      LVP        T   V    
Sbjct: 23227 SGLV---EGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAW 23283

Query: 624   DVQVYDGEDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQ--KGLQH 679
             +  +YDG   +    L     GT  W               ++P  L + +    +G Q+
Sbjct: 23284 EKPLYDGGSRLTGYVLEACKAGTERWM----------KVVTLKPTVLEHTVTSLNEGEQY 23333

Query: 680   RLILHAVKHQDSGALVGFSCPGVQDSAALTIQES---PVHILSPQDRVSLTFTTSERVVL 736
                + A   +      G S P  +   A+T+Q+    P   LS   + ++       V L
Sbjct: 23334 LFRIRAQNEK------GVSEPR-ETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 23386

Query: 737   TCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA 795
                ++    PA +W+  G K+ ESE + V+   +  +L + E  ++D+GE+    + V+ 
Sbjct: 23387 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVT- 23445

Query: 796   FFGVTVQDPPVHIVD----PREHVFVHAITSECVMLACEVDRED--APVRWYKDGQEVEE 849
               G T +   V I+D    P   + +  I +  + ++ E    D  AP+  Y        
Sbjct: 23446 --GTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGY-------- 23495

Query: 850   SDFVVLENEGPHRRLVLPATQ 870
                 V+E    HR   LP ++
Sbjct: 23496 ----VVEQRDAHRPGWLPVSE 23512



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/219 (24%), Positives = 82/219 (37%), Gaps = 32/219 (14%)

Query: 127   APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
             AP F    R+  V   +   L C+  G P+P + W + G  +  + D   +     R ++
Sbjct: 24555 APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEI--IADGLKY-----RIQE 24607

Query: 187   GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
               G    L I +    D+ VY   A N  G     A L+V            E PA +  
Sbjct: 24608 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------------EVPAKI-- 24653

Query: 247   PLKCAPKTFWVNEGKHA------KFRCYVMGKPEPEIEWHWEGRPLLPDRRRL-MYRDRD 299
                  PKT       HA        +    GKP+P I W  +G+ L+ +     +   R 
Sbjct: 24654 ---HLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRS 24709

Query: 300   GGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
                ++     + KD G YV  A+N  G     V+L V +
Sbjct: 24710 FTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 24748



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 58/260 (22%), Positives = 101/260 (38%), Gaps = 55/260 (21%)

Query: 259   EGKHAKFRCYVMGKPEP-EIEWHWEGRPLL-PDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             EG H K+ C +    +  ++ W++  R L   ++  + Y D  G  +L V      D G 
Sbjct: 25209 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED--GVAILYVKDITKLDDGT 25266

Query: 317   YVCAARNSAGQTLSAVQLHVKEPRLRF----TRPLQDVEGREHGIAVLECKVPNSRIP-- 370
             Y C   N  G+  S  +L VK  R  +     R ++ ++ R   + +LE + P   +P  
Sbjct: 25267 YRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLE-RPPEFTLPLY 25325

Query: 371   -----------------------TAWFREDQRLLP---CRKYEQIEEGTVRRLIIHRLKA 404
                                      W++  Q++ P    +KY    +  + +L I+ +  
Sbjct: 25326 NKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTT 25385

Query: 405   DDDGIYLCEMR---GRVRTVANVTVK----------GPILKRLPRKLDVLEGENAVLLVE 451
             DDD  Y    R   G     A +TV            P+ KRL    +  EG++  +  E
Sbjct: 25386 DDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQS--VCFE 25443

Query: 452   TLEAGVEG---RWSRDGEEL 468
                +G+     +W +DG+ L
Sbjct: 25444 IRVSGIPPPTLKWEKDGQPL 25463



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 45/169 (26%), Positives = 63/169 (37%), Gaps = 38/169 (22%)

Query: 85   RARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAE 144
            RA NAAG         + EP  + P  +  + P+ +P       V L    S  V RG E
Sbjct: 8283 RAENAAG---------ISEPSRATPPTKAVD-PIDAP------KVILR--TSLEVKRGDE 8324

Query: 145  VVLTCRAGGLPEPTLYWEKDGMAL-----------------DEVWDSSHFAL---QPGRA 184
            + L     G P PT+ W KD   +                  EV +   F L   Q    
Sbjct: 8325 IALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSI 8384

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
            ++       LR+  +  PD G+Y+    N HG A+A   + V   P  P
Sbjct: 8385 DNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPP 8433



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 6/145 (4%)

Query: 914   ERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC-- 970
             E   L+C++  RP  +++W + G+E+++S    +  +     L +   + ED G Y C  
Sbjct: 24176 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24235

Query: 971   --EIDD-ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGL 1027
               E+ + E++S  +    P     YP  E    AV     + +  + R    + W+    
Sbjct: 24236 TNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK 24295

Query: 1028  EVEESEALVLERDGPRCRLVLPAAQ 1052
              ++ SE + +E       LV+   Q
Sbjct: 24296 LLQNSENITIENTEHYTHLVMKNVQ 24320



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 44/168 (26%), Positives = 71/168 (42%), Gaps = 14/168 (8%)

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTG-EWARGG----VQLYPGPKCHIHSDGHRHRLVL 1598
            +PL+ V + EG +ATF+  +S   V    W R G        PG +    SDG R +L +
Sbjct: 10   QPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDG-RAKLTI 67

Query: 1599 NGLGLADSGCVSFTADS----LRCAARLIVR--EVPVTIVRGPHDLEVTEGDTATFECEL 1652
              +  A+SG  S  A +        A L+V+    P   V+    + V +G     +  +
Sbjct: 68   PAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRV 127

Query: 1653 SQALADVT-WEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYS 1699
            +     V  + +DG  +  S   ++   G    L +    P D+GTYS
Sbjct: 128  TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 61/249 (24%), Positives = 93/249 (37%), Gaps = 58/249 (23%)

Query: 1614 DSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSP 1672
            ++ R  A + +   P T+V G  ++ V EG++ T EC +S      VTW ++   +  S 
Sbjct: 882  ETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI 941

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTAR-----AGPVRLTVRERTVAV-- 1721
              ++        L +R     D+G ++C+     GT       A  V     + T AV  
Sbjct: 942  DFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001

Query: 1722 ---LSELRSVSAR----------------------------------EGDGATFECTV-S 1743
                 E R V +R                                  EG    F C V  
Sbjct: 1002 KFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGG 1061

Query: 1744 EVETTGRWELGGRPLRPGARVRI---RQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
              +    W+  G PL  G R ++   +Q G+   LV+S   A+DAGE    VR + G   
Sbjct: 1062 NPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECK-LVISMTFADDAGEYTIVVRNKHGETS 1120

Query: 1797 SLALLEVEA 1805
            + A L  EA
Sbjct: 1121 ASASLLEEA 1129



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 35/144 (24%), Positives = 63/144 (43%), Gaps = 7/144 (4%)

Query: 232   SPPADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
             S P  P ++  P+  P  K   +   V    +A   C V G P+P ++W+ +G+ ++ D 
Sbjct: 24542 SEPITP-KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 24600

Query: 291   RRLMYRDRDGGF-VLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP-RLRFTRPLQ 348
              +   ++  GG+  L +      D  +Y   A N  G       L V+ P ++   + L+
Sbjct: 24601 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLE 24660

Query: 349   DVEGREHGI--AVLECKVPNSRIP 370
              + G  H +   V+  K+P S  P
Sbjct: 24661 GM-GAVHALRGEVVSIKIPFSGKP 24683



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 2/97 (2%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R   +  G    L  ++ G P P V W+K  +      R+     G++  L +  A   D
Sbjct: 10854 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK--LEIRNAAHED 10911

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
              G+Y     N AG    +  V VL+ P    +L+ +E
Sbjct: 10912 GGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSE 10948



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 75/311 (24%), Positives = 119/311 (38%), Gaps = 33/311 (10%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP + E+ K  KN++ + W  P     +    Y LE+++  S  W +    E      
Sbjct: 20694 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLK-ETIRDTR 20752

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH---VVFHGSAHLV----PTARL---------VA 620
                  +    DY++R+C V+  G+ P      F+ +A  +    P A++         + 
Sbjct: 20753 QKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT 20812

Query: 621   GLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHR 680
                   VYDG  AV    +  I QG      EE  +   +G+V          + G+ + 
Sbjct: 20813 LGWSKPVYDGGSAVTGY-VVEIRQG----EEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 20867

Query: 681   LILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERV-VLTCE 739
               + AV     G  +  + P VQ   A  I E+P   L    R S+     E V VL   
Sbjct: 20868 FRVSAVNCAGQGEPIEMNEP-VQ---AKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPF 20923

Query: 740   LSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE-GV----S 794
               R     TW KD + +       ++       L +P+    D+G++    E GV    S
Sbjct: 20924 KGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKS 20983

Query: 795   AFFGVTVQDPP 805
             +   V V D P
Sbjct: 20984 STVSVKVLDTP 20994



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 5/103 (4%)

Query: 492  AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
            A E  + +G     + +  K  +  PPGPP   E     K+ V LTW  P+    +P   
Sbjct: 7486 AAENMYGVGEPVQASPITAK-YQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITG 7544

Query: 551  YRLERQEVGSEDWIQCFSIE-KAGAVEVPGDCVPSEGDYRFRI 592
            Y +ER +  ++ W++C  +  K     V G  + ++  YRFR+
Sbjct: 7545 YWVERLDPDTDKWVRCNKMPVKDTTYRVKG--LTNKKKYRFRV 7585



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 34/164 (20%), Positives = 71/164 (43%), Gaps = 17/164 (10%)

Query: 823   ECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA 881
             E   L+C++     P ++WY+ G+E+ +S    + ++G    L +   +  D G + C+A
Sbjct: 24176 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24235

Query: 882   GDECAYFTVTITDVSSWIV----------YPSGKVYVAAVRLERVVLTCELCRPWAEVRW 931
              +E     V   + SS ++          YP  + Y  AV     +    + RP   + W
Sbjct: 24236 TNE-----VGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW 24290

Query: 932   TKDGEEVVESPALLLQKEDTVRRLVLPAVQLE-DSGEYLCEIDD 974
                 + +  S  + ++  +    LV+  VQ +  +G+Y  ++ +
Sbjct: 24291 FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSN 24334



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 516  SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
            SPPGPPI   +      T+ L W+PP        + Y +++Q VG+ +W +C   EK   
Sbjct: 8629 SPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC--TEKMIK 8685

Query: 575  VEVPGDCVPSEG-DYRFRICTVSGHGRSP 602
            V         EG DY+ R+  V+  G  P
Sbjct: 8686 VRQYTVKEIREGADYKLRVSAVNAAGEGP 8714



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 32/91 (35%), Positives = 43/91 (47%), Gaps = 7/91 (7%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPE---PAPETPFIYR-LERQEVGS--EDWIQCFSIE 570
            PP PPI  ++    KNTV L+WKPP+    +P T +I   L     G+  E W QC   +
Sbjct: 9639 PPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRD 9698

Query: 571  KAGAVEVPGDCVPSEGDYRFRICTVSGHGRS 601
                     D V   G+Y FR+  V+  G S
Sbjct: 9699 VEELQFTVEDLVEG-GEYEFRVKAVNAAGVS 9728



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 43/144 (29%), Positives = 52/144 (36%), Gaps = 17/144 (11%)

Query: 93    AYAAAAVTVLEPPA-SDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRA 151
             A A  AV +  P   SDP    AE   P           LT      V  G  V L    
Sbjct: 12894 AIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLT------VKAGTNVCLDATV 12947

Query: 152   GGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHA 211
              G P PT+ W+KDG  L    +    A+Q             L + +    DSG Y   A
Sbjct: 12948 FGKPMPTVSWKKDGTLLKPA-EGIKMAMQRNLC--------TLELFSVNRKDSGDYTITA 12998

Query: 212   RNAHGHAQAGALLQVHQPPESPPA 235
              N+ G   A   L+V   P  PPA
Sbjct: 12999 ENSSGSKSATIKLKVLDKP-GPPA 13021



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 8/109 (7%)

Query: 235   ADPDEAPAPVVEPLKCAP-------KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
             +DP +   PV+      P        TF V  G+  K     +G+P P + WH +  P L
Sbjct: 15758 SDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVP-L 15816

Query: 288   PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
                 R+     +   +L +     +D G YV    NSAG+ +  + + V
Sbjct: 15817 KQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15865



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 3/100 (3%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   + V +G   ++   + G P PV+ W K G ++    R    +      L +   
Sbjct: 19421 VKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDC 19480

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLE---PPASDPEL 111
             +  D G YV   +N AG    A    VL+   PPA   E+
Sbjct: 19481 IRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEI 19520



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 11/112 (9%)

Query: 460   RWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             +W+ DG E+         +      L +    R D GE   ++ N+  +  + V      
Sbjct: 11171 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 11230

Query: 517   PPGPPI----LAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
              PGPP     + ++   H   + ++W+PP+    +P I Y +E+Q+   + W
Sbjct: 11231 VPGPPTGPINILDVTPEH---MTISWQPPKDDGGSPVINYIVEKQDTRKDTW 11279



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 3/122 (2%)

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW 538
             M  LV+P  TR+D+G+ + +L N      + V       PGP    ++    K +  ++W
Sbjct: 12288 MAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSW 12347

Query: 539   KPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
              PPE    +    Y +E++E   + W       K  +  V  + VP   +Y FR+  V+ 
Sbjct: 12348 APPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVT-NLVPG-NEYYFRVTAVNE 12405

Query: 598   HG 599
             +G
Sbjct: 12406 YG 12407



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 108/521 (20%), Positives = 190/521 (36%), Gaps = 75/521 (14%)

Query: 475   SSGHMHALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKGH 530
             SS     L++    + DAG+ T +L    G    T  ++V      P GP    E+    
Sbjct: 13661 SSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTA-- 13718

Query: 531   KNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DY 588
                + L W PP+    +    Y LE+++  +  W+ C S  +     V       EG +Y
Sbjct: 13719 -EAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTR---LHEGMEY 13774

Query: 589   RFRICTVS----GHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
              FR+   +    G G     +       VP A     + DV+ +D     ++    T   
Sbjct: 13775 TFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVR-HDSVSLTWTDPKKT--- 13830

Query: 645   GTWFLNGEELKSNEPEGQVEPGALRYRIEQK---------GLQHRLILHAVKHQDSGALV 695
             G   + G  L+  E    +   A +  I  +         GL++   + A+       L 
Sbjct: 13831 GGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAIN------LA 13884

Query: 696   GFSCPGVQDSAALTIQE-----SPVHILSPQDRVSLTFTTSE----RVVLTCELSRVDFP 746
             G   P +     + +        P  I   ++ V+L +T  +      +    + + D P
Sbjct: 13885 GVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLP 13944

Query: 747   A-TWYKDGQ-KVEESELLVVKM-DGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
             + +W K     V E    V  + +G K+   +  AK   +G     +E           +
Sbjct: 13945 SKSWMKANHVNVPECAFTVTDLVEGGKYEFRI-RAK-NTAGAISAPSESTETIICKDEYE 14002

Query: 804   PPVHIVDPREHVFVHAITSECVML-ACEVDREDAPVR-WYKDGQEVEESDFVVLENEGPH 861
              P  ++DP     +     + ++L A  +  +  P   W K G+++  SD   + +    
Sbjct: 14003 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 14062

Query: 862   RRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVV 917
               L +      D GE+   A    G +  +  VT+ DV      P G V ++ V  E+  
Sbjct: 14063 SMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPG----PPGPVEISNVSAEKAT 14118

Query: 918   LTCELCRPWAEVRWT---KDGEEVVESPALLLQKEDTVRRL 955
             LT           WT   +DG   ++S   +L+K +T R L
Sbjct: 14119 LT-----------WTPPLEDGGSPIKS--YILEKRETSRLL 14146



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 43/170 (25%), Positives = 66/170 (38%), Gaps = 14/170 (8%)

Query: 253   KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP--DRRRLMYRDRDGGFVLKVLYCQ 310
             KT +V  G++ +F   +   PEP + W+  G+ + P  + ++  +    G + L +    
Sbjct: 25327 KTAYV--GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVT 25384

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHV--------KEPRLRFTRPLQDVEGREHGIAVLEC 362
               D   Y   ARN  G+     +L V           R  F R L + E +E      E 
Sbjct: 25385 TDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEI 25444

Query: 363   KVPNSRIPT-AWFREDQRLLPCRKYEQIEEG-TVRRLIIHRLKADDDGIY 410
             +V     PT  W ++ Q L      E I EG     L I     +D G Y
Sbjct: 25445 RVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 25494



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 12/128 (9%)

Query: 119  PSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAG----------GLPEPTLYWEKDGMAL 168
            PS  +GE     +      ++  GA+  L C+AG          G P P   WE DG A 
Sbjct: 9420 PSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAK 9479

Query: 169  DEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ 228
              + D  H   +  + E    +S+ + I   +   +G Y   A+N  G   A   ++V  
Sbjct: 9480 KAMKDGVHDIPEDAQLETAENSSVII-IPECKRSHTGKYSITAKNKAGQKTANCRVKVMD 9538

Query: 229  PPESPPAD 236
             P  PP D
Sbjct: 9539 VP-GPPKD 9545



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 27/131 (20%)

Query: 124   GEGAPVFLTGP----------------RSQWVLR-GAEVVLTCRAGGLPEPTLYWEKDGM 166
             G+G P F T P                R +  +R G    LT R  G P+P + W KD  
Sbjct: 10426 GQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEA 10485

Query: 167   ALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
              + E  D +H    P        A+LAL  + A+  DSG Y     N+ G  +    + V
Sbjct: 10486 DVLED-DRTHIKTTP--------ATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNV 10536

Query: 227   HQPPESPPADP 237
                P  PP  P
Sbjct: 10537 VDRP-GPPVGP 10546



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 2/86 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAGAV 575
             P PP+  E      N+V LTW+PP     +  + Y +E Q+VG E+W +   + E     
Sbjct: 10741 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 10800

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             +     +     Y+FR+  V+  G S
Sbjct: 10801 KYKVTGLRDGQTYKFRVLAVNAAGES 10826



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 43/154 (27%), Positives = 67/154 (43%), Gaps = 19/154 (12%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP         K  V L W  P+    +P   Y +E QE G++DWI+  ++     V
Sbjct: 11037 PPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECV 11096

Query: 576   EVPGDCVPSEGDYRFRIC--TVSGHGRSPHVV-FHGSAHLVPTARLVAGLEDVQVYDG-- 630
              V G  +     YRFR+    + G G     +       LVP +  +    DV++ +G  
Sbjct: 11097 -VTG--LQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVEL----DVKLIEGLV 11149

Query: 631   EDAVFSLDLSTIIQGT------WFLNGEELKSNE 658
               A  ++    II+G       W  +G E+K++E
Sbjct: 11150 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE 11183



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 4/113 (3%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILA-EMFKGHKNTVLLTWK- 539
             L++  VTR+D+G  + +  NS  T   ++K V    PGPP    ++     +   L+W  
Sbjct: 12584 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHI 12643

Query: 540   PPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
             P E        Y +E+ +V   DW+   +     +  V G  +P + +Y FR+
Sbjct: 12644 PLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRV-GKLIPGQ-EYIFRV 12694



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 42/163 (25%), Positives = 63/163 (38%), Gaps = 22/163 (13%)

Query: 453   LEAGVEGR------WSRDGEELPVICQ----SSSGHMHALVLPGVTREDAGEVTFSLGNS 502
             LEA + G+      WS+DG+EL          S+     LV+    R D G+    L N 
Sbjct: 18355 LEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV 18414

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKPP-EPAPETPFIYRLERQEVGS 560
               T  + +       PGPP       G       L W PP +        Y +E++E   
Sbjct: 18415 GGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSR 18474

Query: 561   EDWIQCFSIEKAGAVEV----PGDCVPSEGDYRFRICTVSGHG 599
               W Q  +  +A   +V    PG+      +Y FR+  V+ +G
Sbjct: 18475 LSWTQVSTEVQALNYKVTKLLPGN------EYIFRVMAVNKYG 18511



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 39/171 (22%), Positives = 71/171 (41%), Gaps = 12/171 (7%)

Query: 1005  ECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC-- 1061
             E   L C++     P ++WY+ G E+ +S    +  DG    L +   + ED G + C  
Sbjct: 24176 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24235

Query: 1062  --DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQV---RWYK 1116
               + G+      + + A P+   HP     + ++GA G   LR  V   G  V    W+ 
Sbjct: 24236 TNEVGEVETSSKLLLQATPQ--FHPGYPLKEKYYGAVGST-LRLHVMYIGRPVPAMTWFH 24292

Query: 1117  DGLEVEASDALQLGAEGPTRTLTLPHAQPE-DAGEYVCETRHEAITFNVIL 1166
                 ++ S+ + +        L + + Q +  AG+Y  +  +   T + IL
Sbjct: 24293 GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAIL 24343



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 6/112 (5%)

Query: 231 ESPPADPDEAPAPVVEP-----LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
           E+   +    PAPV  P     L    K   V EG+     C++ G P P + W+ E   
Sbjct: 877 EAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 936

Query: 286 LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
            +          + G   L +    A+D G + C+A N AG   ++  L V+
Sbjct: 937 -IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 30/120 (25%), Positives = 52/120 (43%), Gaps = 4/120 (3%)

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKP 540
            LV+P   R D G  T +  N+  T    ++      PGPP+    F+    + + L+W P
Sbjct: 9809 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFP 9868

Query: 541  PEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
            P+    +    Y +E++E   + W+   S  K     +P   +    +Y FRI   + +G
Sbjct: 9869 PKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPK--LLEGHEYVFRIMAQNKYG 9926



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 3/91 (3%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFS 568
             C    PPGPPI  ++    + T  L W  P     +P + Y +E Q+ G+  W  I    
Sbjct: 11426 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11485

Query: 569   IEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
             + +  A  VPG    +E  +R +   + G G
Sbjct: 11486 LIRQCAFRVPGLIEGNEYRFRIKAANIVGEG 11516



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 71/336 (21%), Positives = 122/336 (36%), Gaps = 30/336 (8%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P  P  A + K +K+ + + W  P+    +P I Y +ER+E  S  W++  +     + E
Sbjct: 12720 PSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKA-NDTLVRSTE 12778

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSP------------HVVFHGSAHLVPTARLVAGLED 624
              P   +    +Y FRI  ++  G SP             V   G   ++   +    L  
Sbjct: 12779 YPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIW 12838

Query: 625   VQ-VYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI 682
              +  +DG   +    +    + G  ++         P+ +     L    E+   Q R I
Sbjct: 12839 ARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLE---EKAQYQFRAI 12895

Query: 683   LHAVKHQDSGALVGFSCPG-VQDSAALTIQESPVHI-LSPQDRVSLTFTTSERVVLTCEL 740
                         V  S P    D   +  +  P  I LS   +  LT      V L   +
Sbjct: 12896 ARTA--------VNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 12947

Query: 741   SRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGV 799
                  P  +W KDG  ++ +E + + M      L L     +DSG++    E  S     
Sbjct: 12948 FGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSA 13007

Query: 800   TVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
             T++   +    P   V ++ + S+  ML+ E   ED
Sbjct: 13008 TIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLED 13043



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 22/71 (30%), Positives = 30/71 (42%)

Query: 35    VLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAY 94
             +LG+P P   W K G+ +  S+     +      L +  A   DAG Y   A N  G   
Sbjct: 14031 ILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKV 14090

Query: 95    AAAAVTVLEPP 105
                 VTVL+ P
Sbjct: 14091 EHVKVTVLDVP 14101



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query: 481   ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKP 540
             +L +    R D+G+ T ++ N  +   L +       PGPP    +    K + +L+W  
Sbjct: 19869 SLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDV 19928

Query: 541   PEPAPETPF-IYRLERQEVGSEDWI 564
             PE     P   Y +E++E   + W+
Sbjct: 19929 PENDGGAPVKNYHIEKREASKKAWV 19953



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 27/114 (23%), Positives = 51/114 (44%), Gaps = 7/114 (6%)

Query: 238   DEAPAPVVEPLKCAPKTF---WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLM 294
             DE   P+VE     P+ F    +  G+  + +  V G+P P + W  +G   +  R  + 
Sbjct: 21579 DENVPPIVE---FGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVE-IEKRMNME 21634

Query: 295   YRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQ 348
               D  G   L V       RG+Y   A+N++G   + +++ V++   +   P++
Sbjct: 21635 ITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIR 21688



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 50/248 (20%), Positives = 90/248 (36%), Gaps = 25/248 (10%)

Query: 1384  SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGT----VTLRAGSTATS 1439
             S P A+V W  NG  +    ++          L +  C   D+GT     T   G  +  
Sbjct: 26027 SKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDY 26086

Query: 1440  ARLHV-----------RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQ 1488
             A L V           R  E +      ++   E   V    +T  + A+ +VR V+   
Sbjct: 26087 ATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQM 26146

Query: 1489  PLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLED 1548
                 ++R S++   H     +    L +      +S  +++  R        R+L     
Sbjct: 26147 T---ETRESLSSYEHSASAEMKSAALEE------KSLEEKSTTRKIKTTLAARILTKPRS 26197

Query: 1549  VTISEGGSATFQLELSQEGV-TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG 1607
             +T+ EG SA F  +   E V T  W R G  L    +  + +  ++    ++ +  +D G
Sbjct: 26198 MTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEG 26257

Query: 1608  CVSFTADS 1615
               S   ++
Sbjct: 26258 NYSVVVEN 26265



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 26/108 (24%), Positives = 39/108 (36%), Gaps = 1/108 (0%)

Query: 229   PPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
             P E      D+  AP ++        +   E  + + +  + GKP P + W     PL  
Sbjct: 13594 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLAT 13653

Query: 289   DRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             D  R+          L V  CQ  D G Y    +N AG     + + V
Sbjct: 13654 D-TRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 13700



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 61/268 (22%), Positives = 96/268 (35%), Gaps = 52/268 (19%)

Query: 312   KDRGLYVCAARNSAGQTLSAVQ----LHVKEPRLRF---TRPLQDVEGREHGIAVLECKV 364
             KD  + V AAR S G  + + +      VK   +     +  +    G E G     CK+
Sbjct: 25160 KDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYVCKI 25219

Query: 365   PNSRIPT--AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM---RGRVR 419
              N    T   W+   ++L    KYE   E  V  L +  +   DDG Y C++    G   
Sbjct: 25220 ENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 25279

Query: 420   TVANVTVKG----------PILKRLPRKLDVLE-------------------GENAVLLV 450
             + A + VKG            +K++ R+ D +                    GEN    V
Sbjct: 25280 SYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGV 25339

Query: 451   E-TLEAGVEGRWSRDGEEL-------PVICQSSSGHMHALVLPGVTREDAGEVTFSLGN- 501
               T+       W + G+++           +S  G ++ L +  VT +D  E T    N 
Sbjct: 25340 TITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG-LYQLTINSVTTDDDAEYTVVARNK 25398

Query: 502   -SRTTTLLRVKCVKHSPPGPPILAEMFK 528
                 +   ++    H PP    L  MFK
Sbjct: 25399 YGEDSCKAKLTVTLHPPPTDSTLRPMFK 25426



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 5/116 (4%)

Query: 223   LLQVHQPPESPP---ADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIE 278
             ++ V++   S P   A P  A   V+EP +K A  ++ V  G+  K    + G+P+P I 
Sbjct: 16831 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 16890

Query: 279   WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             W  +G P L    R+   D      L +      D G Y     N  GQ  +++++
Sbjct: 16891 WTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEI 16945



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 1284  GGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCD 1342
             G DL++ + + G   P + W KDGE L    RV +E+     VL ++     D G+Y   
Sbjct: 17954 GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVT 18013

Query: 1343  A 1343
             A
Sbjct: 18014 A 18014



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V+ G   +   YV GKP P + W+   R  LP    +         V+K   CQ   +G+
Sbjct: 10164 VHAGGVIRIIAYVSGKPPPTVTWNMNER-TLPQEATIETTAISSSMVIK--NCQRSHQGV 10220

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y   A+N AG+    + + V
Sbjct: 10221 YSLLAKNEAGERKKTIIVDV 10240



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 32/80 (40%), Gaps = 1/80 (1%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V  G   +F   + G P P  +W  +G  +  D    +  D     VL +  C  +D G 
Sbjct: 11150 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS-VLTIKNCLRRDTGE 11208

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y     N+AG    AV L V
Sbjct: 11209 YQITVSNAAGSKTVAVHLTV 11228



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 1/68 (1%)

Query: 1274  AAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
             A +T V +  G D+++++   G P   V W KD + L S  R  +E   +  +L +    
Sbjct: 20904 ALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVT 20963

Query: 1333  SGDAGEYL 1340
               D G+Y+
Sbjct: 20964 RNDTGKYI 20971



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 1/50 (2%)

Query: 518  PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
            P PP+        +++V L W+PP     +P + Y +ER E G ++WI+C
Sbjct: 6920 PSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 6969



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 4/92 (4%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
             +PPG P    +    + +V L W  PE    +    Y +E Q+V   +W +C +      
Sbjct: 23659 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKC-NTTPTKI 23717

Query: 575   VEVPGDCVPSEGDYRFRI--CTVSGHGRSPHV 604
              E     +P   +YRFR+  C   G G    V
Sbjct: 23718 REYTLTHLPQGAEYRFRVLACNAGGPGEPAEV 23749



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)

Query: 19   RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
            + V V    +A  +CV+  E    V+W KG   + +S++    ADG +H L++  +   D
Sbjct: 5121 KDVTVPERRQARFECVLTREAN--VIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDD 5178

Query: 79   AGVY 82
             GVY
Sbjct: 5179 EGVY 5182



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 3/106 (2%)

Query: 231  ESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
            E    D  EAP   ++    A  T  V  G   +    V GKPEP+I W  +   +L   
Sbjct: 7306 EIQAVDTQEAPEIFLDVKLLAGLT--VKAGTKIELPATVTGKPEPKITW-TKADMILKQD 7362

Query: 291  RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            +R+   +      + ++  +  D G Y+  A N  G+  + V+++V
Sbjct: 7363 KRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7408



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 17/49 (34%), Positives = 29/49 (59%), Gaps = 1/49 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQ 565
             PGPP   ++F   ++ + LTW PPE    +    Y +ER+EV ++ W++
Sbjct: 23560 PGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVR 23608



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 6/88 (6%)

Query: 1725  LRSVSAREGDGATFECTVSEVET-TGRWELGGRPLRPGARVRIRQEG-KKHILVLSELRA 1782
             L +   +EG    FE  VS +   T +WE  G+PL  G  + I  EG   + L + +   
Sbjct: 25429 LANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLP 25488

Query: 1783  EDAGEVRF----QAGPAQSLALLEVEAL 1806
             ED G  R      AG     A L+VE L
Sbjct: 25489 EDTGYYRVTATNTAGSTSCQAHLQVERL 25516



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 518  PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFSIEKAGA 574
            PGPP   ++    K ++L++W PP     +P   Y LE++E GS  W  +    I K G 
Sbjct: 9227 PGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGL 9286

Query: 575  VEVPGDCVPS--EG-DYRFRICTVSGHGRSP 602
              V  + VP   EG  Y+FR   ++  G  P
Sbjct: 9287 KGVEFN-VPRLLEGVKYQFRAMAINAAGIGP 9316



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 129/621 (20%), Positives = 223/621 (35%), Gaps = 84/621 (13%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PP PP    +    + +  L W+ PE    +  + Y +E Q  G+E W      +   AV
Sbjct: 17840 PPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAV 17899

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS-PHV----VFHGSAHLVPTARLVAGLEDVQVYDG 630
              V G  + S  +Y+FR+   +  G+S P V    V      + P+ +L      +Q   G
Sbjct: 17900 -VTG--LSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQA--G 17954

Query: 631   EDAVFSLDLSTIIQG----TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
             ED    +++  I +     +W  +GE LK             R  +E+      L +   
Sbjct: 17955 ED--LKIEIPVIGRPRPNISWVKDGEPLKQ----------TTRVNVEETATSTVLHIKEG 18002

Query: 687   KHQDSG---ALVGFSCPGVQDSAALTIQESPVHILSPQ--DRVSLTFT--TSERVVLT-- 737
                D G        S     ++ ++ + E P   + P   D VS  F   + E    T  
Sbjct: 18003 NKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGG 18062

Query: 738   CELS------RVDFPATWYKDGQKVEESELLVVKM-DGRKHRL-ILPEAKVQDSGEFECR 789
             C++S      R     TW+     V  + + + K+  G +++  I  E +   S   + +
Sbjct: 18063 CQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSK 18122

Query: 790   TEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR--WYKDGQEV 847
                        +   P     P    FV +I+ + +++       D   +   Y   Q+ 
Sbjct: 18123 ---------AVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKE 18173

Query: 848   EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY-----P 902
             + S   V  N+ P +      T   +G E++     E        + VS   V      P
Sbjct: 18174 KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP 18233

Query: 903   SGKVYVAAVRLERVVLT---------CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVR 953
              G+     +    V L           ++     E +   DG  +  S   +L+ E TV 
Sbjct: 18234 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 18293

Query: 954   RLV------LPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECV 1007
              LV         +    +G +    D   A       + P   + P+ +  ++    E  
Sbjct: 18294 GLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETF 18353

Query: 1008  VLMCELSREDAP-VRWYKDGLEVEESEA-LVLERDGPRCRLVLPAAQPEDGGEFVCD--- 1062
             VL  ++  +  P V W KDG E+EE+ A + ++    +  LV+      DGG+++     
Sbjct: 18354 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 18413

Query: 1063  -AGDDSAFFTVTV---TAPPE 1079
               G  S   TV V     PPE
Sbjct: 18414 VGGTKSIPITVKVLDRPGPPE 18434



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/146 (20%), Positives = 63/146 (43%), Gaps = 7/146 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DGE L    +     +     L +    ++D G+ T +  NS  T    +  +    
Sbjct: 17973 WVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 18032

Query: 518   PGPPILAEMF-KGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PGPP+    F +   + V+++W+PP          Y +E+++  +  W    +      +
Sbjct: 18033 PGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTI 18092

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             ++    + +  +Y+FRI   + +G+S
Sbjct: 18093 KITK--LKTGTEYQFRIFAENRYGKS 18116



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 190/979 (19%), Positives = 339/979 (34%), Gaps = 168/979 (17%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQ---EVGSEDWIQC-FSIEKA 572
             PG P + ++ +   +TV L W  P     +  + Y +ER+   EVG   W++C ++I   
Sbjct: 22570 PGRPEVTDVTR---STVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSD 22626

Query: 573   GAVEVPGDCVPSEGD-YRFRICTVSGHG------RSPHVVFHGSAHLVPTARLVAGLED- 624
                 V      SEGD Y FR+   +  G       S   V     +  P A L A L   
Sbjct: 22627 NFFTVTA---LSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGD 22683

Query: 625   -VQVYDGEDAVFSLDLSTIIQGT------WFLNGEELKSNEPEGQVEPGALRYRIEQKGL 677
              V +  G D V    L   + G       W    +EL   E          +  ++  G 
Sbjct: 22684 LVTIRAGSDLV----LDAAVGGKPEPKIIWTKGDKELDLCE----------KVSLQYTGK 22729

Query: 678   QHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
             +   ++      DSG     +      + A+++    +    P  +++++  T E+  L 
Sbjct: 22730 RATAVIKFCDRSDSGKYT-LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLA 22788

Query: 738   CELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
               L + D  A   +   ++ E S L  V ++G    L     ++  + E+  R   V+ +
Sbjct: 22789 WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKY 22848

Query: 797   F-GVTVQDPPV----------------HIVDPREHVFVHAITSEC-----VMLACEVDRE 834
               GV V+  P+                 +   +EH+ +     E      +       RE
Sbjct: 22849 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKRE 22908

Query: 835   DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
                +RW +  +     D+VV +         L  T   +G ++Q       A      ++
Sbjct: 22909 KKSLRWTRVNK-----DYVVYDTR-------LKVTSLMEGCDYQFRVTAVNAAGNSEPSE 22956

Query: 895   VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTK---DGEEVVESPALLLQKEDT 951
              S++I               RVV T +       + WTK   DG   +    L +Q++DT
Sbjct: 22957 ASNFISCREPSYTPGPPSAPRVVDTTKHS---ISLAWTKPMYDGGTDIVGYVLEMQEKDT 23013

Query: 952   -----------VRRLVLPAVQLEDSGEYLCEIDDESA------SFTVTVTEPPVRIIYPR 994
                        +R        L+   +Y   +   +       S ++   EP  RI  P 
Sbjct: 23014 DQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPD 23073

Query: 995   DEVT---LIAVTLEC---VVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLV 1047
              E+       VT+     + LM  +S    PV  W K G+++  +   +++       L+
Sbjct: 23074 LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDL--ASRAIIDTTESYSLLI 23131

Query: 1048  LPAAQPEDGGEFVCDAGDDSAFFTVTVTA---------PPERIVHPAARSLDLHFGAP-- 1096
             +      D G++  +A + S   + TV           P  ++   +  S+ + +  P  
Sbjct: 23132 VDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 23191

Query: 1097  --GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDA---GEY 1151
               G       V    + +R +K  +  + S  L   +     T+      PE+    GE 
Sbjct: 23192 DGGAPVNNYIVEKREAAMRAFKT-VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE- 23249

Query: 1152  VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVV--------LSCELSRAGA- 1202
              CET    +   V L   P +   ++ T S + +A  +P+            E  +AG  
Sbjct: 23250 PCETSDAVLVSEVPLV--PAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTE 23307

Query: 1203  ---------PVVWSHNGRPVQEGEG--LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAP 1251
                      P V  H    + EGE     + A+  + V                   + P
Sbjct: 23308 RWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGV-------------------SEP 23348

Query: 1252  GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA 1310
                  + TVQ       +      Q  +    G  +ELV+ ++G P     W+  G +L 
Sbjct: 23349 RETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR 23408

Query: 1311  SQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLT 1370
                RV +E       L ++     D GEY  +    +     +++  +L K      P+ 
Sbjct: 23409 ESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIK 23468

Query: 1371  VHEGDDATFRCEVSPPDAD 1389
             + E D  +      PP+ D
Sbjct: 23469 IDEIDATSITISWEPPELD 23487



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 50/188 (26%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 705 SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVV 764
           SA  + Q+    + +P  + S T   +E   L  +    D P T YK    VE  + + V
Sbjct: 801 SATSSAQKITKSVKAPTVKPSETRVRAEPTPLP-QFPFADTPDT-YKSEAGVEVKKEVGV 858

Query: 765 KMDG---RKHRLIL---PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
            + G   R+ R  +    EAKV ++       E         +   P  +V   ++V V 
Sbjct: 859 SITGTTVREERFEVLHGREAKVTETARVPAPVE---------IPVTPPTLVSGLKNVTV- 908

Query: 819 AITSECVMLACEVDREDAP-VRWYKDGQEVEES-DFVVLENEGPHRRLVLPATQPSDGGE 876
            I  E V L C +    +P V WY++  ++E S DF +    G   RL++      D G 
Sbjct: 909 -IEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG-IARLMIREAFAEDSGR 966

Query: 877 FQCVAGDE 884
           F C A +E
Sbjct: 967 FTCSAVNE 974



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 3/92 (3%)

Query: 332 VQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIE 390
           V++ V  P L     L++V   E     LEC +     PT  W+RED ++     ++   
Sbjct: 890 VEIPVTPPTL--VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 391 EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
           +  + RL+I    A+D G + C       TV+
Sbjct: 948 QSGIARLMIREAFAEDSGRFTCSAVNEAGTVS 979



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 33/111 (29%), Positives = 46/111 (41%), Gaps = 7/111 (6%)

Query: 229  PPESPP---ADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
            P E+ P   A+P E PA  VE          +  GK  +    V G+P P   W  E   
Sbjct: 8715 PGETQPVTVAEPQEPPA--VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGE 8772

Query: 286  LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            L  D+ R++  +      L +     KD G YV  A NS G   +A ++ V
Sbjct: 8773 L--DKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 8821



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 23/83 (27%), Positives = 35/83 (42%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    +   V G+PPP V W    + L     +   A  +   +++     +  GVY
Sbjct: 10164 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSS--MVIKNCQRSHQGVY 10221

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+N AGE      V VL+ P
Sbjct: 10222 SLLAKNEAGERKKTIIVDVLDVP 10244



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 21/90 (23%), Positives = 36/90 (40%), Gaps = 2/90 (2%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
             G + +++  + G P P + W K G  L  + R++         L +      D G Y   
Sbjct: 16872 GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGIT 16931

Query: 86    ARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
               N  G+  A+  +  L+ P  DP   P +
Sbjct: 16932 VANVVGQKTASIEIVTLDKP--DPPKGPVK 16959



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 93/414 (22%), Positives = 145/414 (35%), Gaps = 55/414 (13%)

Query: 226   VHQPPES--PPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             + +P +S  P    DE   P +        T  VN G+  +    V GKP P IEW   G
Sbjct: 17232 ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW-LRG 17290

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV------- 336
                + +  R   ++ D   +L V      D G Y+  A N AG     V + V       
Sbjct: 17291 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17350

Query: 337   -----------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW-FREDQRLLPCR 384
                        ++  L ++ PLQD  G +    V+E K   SR+  AW     + +    
Sbjct: 17351 EGPVQVTGVTSEKCSLTWSPPLQD-GGSDISHYVVE-KRETSRL--AWTVVASEVVTNSL 17406

Query: 385   KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP-ILKRLPRKLDVLEG 443
             K  ++ EG     +   +  +  G+      G     A V +K P +L   P+ L+V   
Sbjct: 17407 KVTKLLEG--NEYVFRIMAVNKYGV------GEPLESAPVLMKNPFVLPGPPKSLEVTNI 17458

Query: 444   ENAVLLV-----------ETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDA 492
                 + V           E +   VE R  R G    + C         L + G+T +  
Sbjct: 17459 AKDSMTVCWNRPDSDGGSEIIGYIVEKR-DRSGIRW-IKCNKRRITDLRLRVTGLTEDHE 17516

Query: 493   GEVTFS------LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW-KPPEPAP 545
              E   S      +G     T+    C     PGPP  A +    KN++ L W KP     
Sbjct: 17517 YEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGG 17576

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                  Y +E  +   E+W                  +    +Y+ R+C ++  G
Sbjct: 17577 SEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVG 17630



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
             V + DAG+   +L NS       +       PGPP+   + +  K++  +TW+PP     
Sbjct: 13384 VNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGG 13443

Query: 547   TPFI-YRLERQEVGSEDW 563
             +P I Y +++++   + W
Sbjct: 13444 SPIINYVVQKRDAERKSW 13461



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 4/91 (4%)

Query: 514   KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKA 572
             +  PPGPP   E+    KNT  ++WK P     +    Y +ER+E  S  W++      +
Sbjct: 14196 RFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVS 14255

Query: 573   G-AVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
                 +V G  +     Y FR+   +  G  P
Sbjct: 14256 DLRCKVTG--LQEGSTYEFRVSAENRAGIGP 14284



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 1/82 (1%)

Query: 461   WSRDGEELPVICQSSSGHMHA-LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
             WSR+  E     Q   G  +  L +    R DAG+    L NS  +    V       PG
Sbjct: 17686 WSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPG 17745

Query: 520   PPILAEMFKGHKNTVLLTWKPP 541
             PP    + +  K++  L W+PP
Sbjct: 17746 PPQNLAVKEVRKDSAFLVWEPP 17767



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 18/64 (28%), Positives = 28/64 (43%), Gaps = 3/64 (4%)

Query: 1657  ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAG---PVRLT 1713
             A V W KDG  L  + R+ + +  T   L ++     D GTY   V  +      P+ + 
Sbjct: 19052 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITII 19111

Query: 1714  VRER 1717
             V +R
Sbjct: 19112 VLDR 19115



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 269   VMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQ 327
             V GKPEP+I W    + L L ++  L Y  +    V+K  +C   D G Y    +N++G 
Sbjct: 22699 VGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIK--FCDRSDSGKYTLTVKNASGT 22756

Query: 328   TLSAVQLHV 336
                +V + V
Sbjct: 22757 KAVSVMVKV 22765



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 22/81 (27%), Positives = 30/81 (37%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G    L   V G PPP + W K    L     L   +   +  L        DAG Y+ 
Sbjct: 13335 AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYIL 13394

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N+ G+      V VL+ P
Sbjct: 13395 TLENSCGKKEYTIVVKVLDTP 13415



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 8/102 (7%)

Query: 1351  LVSVEEPLLVKLVSELTPLTVHEGDDATFRCE-VSPPDADVTWLRNGAVVTPGPQVEMAQ 1409
             L S E P + K   E+  +T   G+ A   C+ V  P  D+ W R G  +    + +M+ 
Sbjct: 24155 LTSGEAPGIRK---EMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSS 24211

Query: 1410  NGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRET 1447
             +G +  LT+   +  D G  T  A    G   TS++L ++ T
Sbjct: 24212 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 24253



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 10/128 (7%)

Query: 1775  LVLSELRAEDAGEVRFQAGPAQS---LALLEVEALPLQMCRHPPREKTVLVGRRAVLEVT 1831
             +V+S  R    G +R Q G + +   +A +E+  +  Q+  H   E+   V  + V ++ 
Sbjct: 25164 MVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIM-HAVGEEGGHV--KYVCKIE 25220

Query: 1832  VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDST 1887
                    V W     +L   +KYE+        L + D+   D GTY C+     G+DS+
Sbjct: 25221 NYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS 25280

Query: 1888  HTRLLVEG 1895
             +  L V+G
Sbjct: 25281 YAELFVKG 25288



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 51/238 (21%), Positives = 89/238 (37%), Gaps = 41/238 (17%)

Query: 965   SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
             S EY   +  E+    V V+EPP+    P   VTL+ VT           R  A ++W K
Sbjct: 18903 SNEYGIGLPAETTE-PVKVSEPPL----PPGRVTLVDVT-----------RNTATIKWEK 18946

Query: 1025  ---DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVT----AP 1077
                DG        + ++  G          +  +       AG++  F    V     + 
Sbjct: 18947 PESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSD 19006

Query: 1078  PERIVHPA-ARSLDLH---------FGAPGRVELRCEVAPAG---SQVRWYKDGLEVEAS 1124
             P ++  P  AR +++          F    R +L+ +V   G   + V W KDG  ++ +
Sbjct: 19007 PRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKET 19066

Query: 1125  DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
               + + +     +L++  A  ED G Y     + A +  V     P+  + L+    P
Sbjct: 19067 TRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITV-----PITIIVLDRPGPP 19119



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 8/116 (6%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKH-SPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
             V  E+A  V  + G SR      +KC +  +PPGPP + ++    K TV L W  P    
Sbjct: 21855 VMAENAAGVGPASGISRL-----IKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDG 21909

Query: 546   ETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
                 I Y +E  +    DW +  + E           + +  +Y+FR+  ++G G+
Sbjct: 21910 GMEIIGYIIEMCKADLGDWHK-VNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 21964



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 30/114 (26%), Positives = 48/114 (42%), Gaps = 7/114 (6%)

Query: 489  REDAGEVTFSLGN--SRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
            R D G       N   R T ++ V  +    PGPP   ++      + LLTW PP     
Sbjct: 7383 RSDTGTYIIEAVNVCGRATAVVEVNVL--DKPGPPAAFDITDVTNESCLLTWNPPRDDGG 7440

Query: 547  TPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
            +    Y +ER+   SE W +  S  K    +     +P++ +Y FR+   + +G
Sbjct: 7441 SKITNYVVERRATDSEVWHKLSSTVKDTNFKAT-KLIPNK-EYIFRVAAENMYG 7492



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 19/79 (24%), Positives = 36/79 (45%)

Query: 925  PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT 984
            P   V W KDG+EV  S  L ++ +     L +P     D+G Y   ++++  S T ++ 
Sbjct: 8042 PVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASIN 8101

Query: 985  EPPVRIIYPRDEVTLIAVT 1003
               + +  P  ++    +T
Sbjct: 8102 VKVIGLPGPCKDIKASDIT 8120



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 16/55 (29%), Positives = 30/55 (54%)

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
            V W+KDG+EV+ SD + ++N+     L +P +  +D G +     ++    T +I
Sbjct: 8046 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASI 8100



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 17/40 (42%), Positives = 24/40 (60%)

Query: 1112 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
            V W+KDG EV+ASD L +  +  +  L +P +   DAG Y
Sbjct: 8046 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 8085



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 18/57 (31%), Positives = 29/57 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT 980
             +P    +W K  +EVV S  L + K D+   L++  V  +DSG Y    ++ S + T
Sbjct: 12553 KPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDT 12609



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 15/149 (10%)

Query: 748   TWYKDGQKV---EESELLVVKMDGRKHRLILPEAKVQDSGEF------ECRTEGVSAFFG 798
             TWYK GQK+   +  +    + D   ++L +      D  E+      +   +   A   
Sbjct: 25350 TWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLT 25409

Query: 799   VTVQDPPVH--IVDPREHVFVHAITSECVMLACEVDREDAP---VRWYKDGQEVEESDFV 853
             VT+  PP    +    + +  +A   E   +  E+     P   ++W KDGQ +     +
Sbjct: 25410 VTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNI 25469

Query: 854   VLENEG-PHRRLVLPATQPSDGGEFQCVA 881
              + +EG  +  L +  T P D G ++  A
Sbjct: 25470 EIIHEGLDYYALHIRDTLPEDTGYYRVTA 25498



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 18   PRPVRVVSGAEAELKC--------VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            PRP+ ++ G   +  C        V +       VW K GQ++  S+R+    D   H L
Sbjct: 2307 PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2366

Query: 70   LLTAALPTDAGVY 82
            L+      DAG Y
Sbjct: 2367 LIEDMTKEDAGNY 2379



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 18/60 (30%), Positives = 30/60 (50%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             LV+  VTR D+G    +L N+  +    V       P  P+   + +  K++V L+W+PP
Sbjct: 18791 LVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPP 18850



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 41/171 (23%), Positives = 64/171 (37%), Gaps = 28/171 (16%)

Query: 63    DGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             D +E    +T   P D   +   ARNA G        T+  P  S   +   +  +P   
Sbjct: 21535 DVSECQYTVTGLSPGDRYEFRIIARNAVG--------TISPPSQSSGIIMTRDENVP--- 21583

Query: 123   SGEGAPVFLTGPR---SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                  P+   GP       +  G  + +     G P P + W KDG+ +++  +      
Sbjct: 21584 -----PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---- 21634

Query: 180   QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPP 230
                   D  G S +L +  A     GVY   A+NA G A+A   ++V   P
Sbjct: 21635 ----ITDVLG-STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 21680



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 22/91 (24%), Positives = 41/91 (45%), Gaps = 1/91 (1%)

Query: 1183  LCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG 1241
             L +  GE + +   +     P V W  +G  +++   +E+        L ++ A   H G
Sbjct: 21596 LIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 21655

Query: 1242  LYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
             +YT ++  A G+      V+V + P +VV P
Sbjct: 21656 VYTVEAKNASGSAKAEIKVKVQDTPGKVVGP 21686



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 39/167 (23%), Positives = 65/167 (38%), Gaps = 32/167 (19%)

Query: 453   LEAGVEGR------WSRDGEELPVICQSSS----GHMHALVLPGVTREDAGEVTFSLGNS 502
             L+A V G+      W++  +EL  +C+  S    G     V+    R D+G+ T ++ N+
Sbjct: 22695 LDAAVGGKPEPKIIWTKGDKELD-LCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNA 22753

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWK-PPEPAPETPFIYRLERQEVGSE 561
               T  + V       PGP     + +  +    L W  P E        Y +ER+E    
Sbjct: 22754 SGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRL 22813

Query: 562   DWIQCFSIEKAGAVEVPGDC---------VPSEGDYRFRICTVSGHG 599
             +W           V V G+C         +    +Y FR+  V+ +G
Sbjct: 22814 NW-----------VIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYG 22849



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 1/67 (1%)

Query: 1721  VLSELRSVSAREGDGATFEC-TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
             +L++ RS++  EG+ A F C T  E   T  W   G+ L   AR ++     K    +S 
Sbjct: 26191 ILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISS 26250

Query: 1780  LRAEDAG 1786
             ++A D G
Sbjct: 26251 VQASDEG 26257



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 9/97 (9%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            V  G ++ L     G PEP + W K  M L +        +     E+ P  S  + I+ 
Sbjct: 7330 VKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITI-----ENVPKKS-TVTIVD 7380

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPA 235
            ++  D+G Y+  A N  G A A   + V   P  P A
Sbjct: 7381 SKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAA 7417



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 32/111 (28%), Positives = 44/111 (39%), Gaps = 11/111 (9%)

Query: 134   PRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193
             P    +  G ++ +     G P PT  W+K     DEV  SSH A+          +S  
Sbjct: 12533 PEQITIKAGKKLRIEAHVYGKPHPTCKWKK---GEDEVVTSSHLAVHKA------DSSSI 12583

Query: 194   LRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQP-PESPPADPDEAPA 242
             L I      DSG Y   A N+ G   Q   ++ +  P P  PP D  +  A
Sbjct: 12584 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDA 12634



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 13/89 (14%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             RP  EV+W +D  E ++  +  ++   +   L++  V   DSG+Y+  +++ S S +  V
Sbjct: 15515 RPAPEVKWARDHGESLDKAS--IESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 15572

Query: 984   TEPPVRII----YPRD----EVTLIAVTL 1004
                 VR++     P+D    EVT  +VTL
Sbjct: 15573 N---VRVLDTPGPPQDLKVKEVTKTSVTL 15598



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 1640  VTEGDTATFECEL-SQALADVTWEKDGNAL-TPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             V  G+T   E ++  + + DV W KDG  L   + R+ +++   +  L ++ C  +D G 
Sbjct: 18347 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 18406

Query: 1698  YSCA---VGTARAGPVRLTVRER 1717
             Y      VG  ++ P+ + V +R
Sbjct: 18407 YILKLSNVGGTKSIPITVKVLDR 18429



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             C  + PPGPP   E+    K+++++TW  P     T    Y LE+++     W +C
Sbjct: 18524 CNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKC 18579



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 29/119 (24%), Positives = 53/119 (44%), Gaps = 10/119 (8%)

Query: 491   DAGEVTFSLGNSRTTTLLRVKCVKHSPPGPP----ILAEMFKGHKNTVLLTWKPPE-PAP 545
             DAG    +  NS  TT   +  V    PGPP    +++++    + +V L W+PP+    
Sbjct: 20171 DAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDI---TEESVTLKWEPPKYDGG 20227

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                  Y L ++E  +  W +  +      ++V    + +  +Y+FRI   +  G S H+
Sbjct: 20228 SQVTNYILLKRETSTAVWTEVSATVARTMMKVMK--LTTGEEYQFRIKAENRFGISDHI 20284



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 24/92 (26%), Positives = 36/92 (39%), Gaps = 2/92 (2%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             R+   + V  G    L   + G+P P+  W K GQ +  S+R           L++  A 
Sbjct: 23769 RYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI--SKRAMIATSETHTELVIKEAD 23826

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS 107
               D+G Y     N  G+      V V+  P S
Sbjct: 23827 RGDSGTYDLVLENKCGKKAVYIKVRVIGSPNS 23858



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 33/158 (20%), Positives = 60/158 (37%), Gaps = 22/158 (13%)

Query: 720  PQDRVSLTFTTSERVVLTCELSRVDFP--------ATWYKDGQKVEESELLVVKMDGRKH 771
            P  + ++   T + +V+  E   +  P         +W+KDG++V+ S+ L +K D    
Sbjct: 8011 PDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISA 8070

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEV 831
             L +P++   D+G +    E        ++    + +  P + +    IT     L  E 
Sbjct: 8071 HLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEP 8130

Query: 832  DRED--APVRWYKDGQEVEESDFVVLENEGPHRRLVLP 867
               D   P+  Y            VLE     RR  +P
Sbjct: 8131 PEFDGGTPILHY------------VLERREAGRRTYIP 8156



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 1638  LEVTEGDTATFECEL-SQALADVTWEKDGNA--LTPSPRLRLQALGTRRLLQLRRCGPSD 1694
             L V  GDT   E  +  +   +V W KD +A  LT SPR+++          L +   SD
Sbjct: 11839 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSD 11898

Query: 1695  AGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV-SAREGDGATFECTV 1742
              G Y     T  AG     V   TV VL +   V + +  D ++  CTV
Sbjct: 11899 GGKY-VVTATNTAGSF---VAYATVNVLDKPGPVRNLKIVDVSSDRCTV 11943



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 17/173 (9%)

Query: 1096  PGRVELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
             PG   +RC  AP    Q  +   GLE +A    Q  A   T     P ++P D    + E
Sbjct: 12860 PGDKWVRCNTAPHQIPQEEYTATGLEEKAQ--YQFRAIARTAVNISPPSEPSDPVTILAE 12917

Query: 1155  TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPV 1213
                  I  +V +              S L V  G  V L   +     P V W  +G  +
Sbjct: 12918 NVPPRIDLSVAMK-------------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLL 12964

Query: 1214  QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
             +  EG+++  +     L + +     +G YT  +  + G+ S +  ++V + P
Sbjct: 12965 KPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 13017



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K+TV L W KP          Y +E Q  GS+ W    +++  G   
Sbjct: 14593 PSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVK--GLEC 14650

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V  +    E +Y F++  V+  GRS
Sbjct: 14651 VVRNLTEGE-EYTFQVMAVNSAGRS 14674



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 26/102 (25%), Positives = 41/102 (40%), Gaps = 8/102 (7%)

Query: 232   SPPADP-------DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGR 284
             SPP++P       D+  AP ++       T  +  G+  +    V G+P P +EW  +G+
Sbjct: 15069 SPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGK 15128

Query: 285   PLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG 326
               L    +L  +  D    L       +D G Y   A N  G
Sbjct: 15129 E-LEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGG 15169



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 20/87 (22%), Positives = 36/87 (41%)

Query: 833   REDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
             R  A V W KDGQ ++E+  V + +      L +      D G ++    +     TV I
Sbjct: 19049 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 19108

Query: 893   TDVSSWIVYPSGKVYVAAVRLERVVLT 919
             T +      P G + +  V  + + ++
Sbjct: 19109 TIIVLDRPGPPGPIRIDEVSCDSITIS 19135



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K++V LTW  PE    +  + Y +E  E G ++W++C ++ K+    
Sbjct: 20003 PSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKC-AVAKSTHHV 20061

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V G  +    +Y FR+   +  G S
Sbjct: 20062 VSG--LRENSEYFFRVFAENQAGLS 20084



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD---ESASFT 980
             RP   V W KD + +       ++  D+   L +P V   D+G+Y+  I++   E  S T
Sbjct: 20926 RPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 20985

Query: 981   VTV 983
             V+V
Sbjct: 20986 VSV 20988



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 23/89 (25%), Positives = 35/89 (39%), Gaps = 9/89 (10%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G+++VL    GG PEP + W K    LD          +      G  A+  ++      
Sbjct: 22690 GSDLVLDAAVGGKPEPKIIWTKGDKELD-------LCEKVSLQYTGKRATAVIKF--CDR 22740

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPP 230
              DSG Y    +NA G      +++V   P
Sbjct: 22741 SDSGKYTLTVKNASGTKAVSVMVKVLDSP 22769



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 2/75 (2%)

Query: 1637  DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
             D+    G+ A   C++  + L D+ W + G  L  S + ++ + G    L +      D 
Sbjct: 24169 DVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 24228

Query: 1696  GTYSCAVGTARAGPV 1710
             G Y+C + T   G V
Sbjct: 24229 GVYTC-IATNEVGEV 24242



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 18/76 (23%), Positives = 32/76 (42%)

Query: 37   GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
            G P P   W  G + L   +R+      A   L+++ +  +D G+Y  +  N        
Sbjct: 7048 GYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGE 7107

Query: 97   AAVTVLEPPASDPELQ 112
              V V+  P++  EL+
Sbjct: 7108 IDVNVIARPSAPKELK 7123



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
            PP PP   E+    KNT  L W  PE    +P   Y +E+++V  + W
Sbjct: 7711 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGW 7758



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 8/99 (8%)

Query: 25   SGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADG----AEHG--LLLTAALP 76
            +G++  +  V+ G P P   WE  G+   A +      P D     AE+   +++     
Sbjct: 9452 AGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKR 9511

Query: 77   TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
            +  G Y   A+N AG+  A   V V++ P    +L+ ++
Sbjct: 9512 SHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSD 9550



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 6/70 (8%)

Query: 924   RPWAEVRWTKDGE--EVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF-- 979
             +P+ EV WTKD +  ++  SP + +       +  L   +  D G+Y+    + + SF  
Sbjct: 11856 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVA 11915

Query: 980   --TVTVTEPP 987
               TV V + P
Sbjct: 11916 YATVNVLDKP 11925



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/81 (23%), Positives = 34/81 (41%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G+   +   + G P P V W+    +L  ++R+S         L +  ++  D+G Y  
Sbjct: 22289 AGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFL 22348

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N AG    +  V V+  P
Sbjct: 22349 TLENTAGVKTFSVTVVVIGRP 22369



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 4/93 (4%)

Query: 1432  RAGSTATSARLHVRETELLFLRR-LQDVRAEEGQDVCLEVE-TGRVGAAGAVRWVRGGQP 1489
             R   TA S +  +   E   +R+ ++DV  + G+   L  +  GR      ++W R G+ 
Sbjct: 24143 RPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGR--PLPDIKWYRFGKE 24200

Query: 1490  LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC 1522
             L    +  M+ DG  H L +      D+G Y C
Sbjct: 24201 LIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 24233



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 15/102 (14%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGG-------QQLAASERLSFPADGAEHGLLLTA 73
             V V +G    L  +V G P P V W K G        Q+   + ++F        L++  
Sbjct: 12244 VIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF--------LVIPN 12295

Query: 74    ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
             +   D+G Y     N AGE      V VL+ P    +L+ ++
Sbjct: 12296 STRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSD 12337



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 16/60 (26%), Positives = 30/60 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             +P   V W KDG  +  +  + +  +  +  L L +V  +DSG+Y    ++ S S + T+
Sbjct: 12950 KPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATI 13009



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 14/38 (36%), Positives = 22/38 (57%)

Query: 1114  WYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
             W K G ++  SD  Q+ +   +  LT+ +A  +DAGEY
Sbjct: 14041 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEY 14078



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 1/84 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP    +    K +  L W KP          Y +E Q+VG E WI+  +       
Sbjct: 14300 PPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 14359

Query: 576   EVPGDCVPSEGDYRFRICTVSGHG 599
             +     + ++  Y FRI  ++  G
Sbjct: 14360 QFVVPDLQTKEKYNFRISAINDAG 14383



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 7/97 (7%)

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGLEVEASDALQLGAEGPTRT 1137
             ++ PA + L   F      +L+ +V   G     V W+KD + ++ +  +   +      
Sbjct: 15773 VIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSL 15832

Query: 1138  LTLPHAQPEDAGEYVCETRH---EAI-TFNVILAEPP 1170
             LT+  A  ED G YV +  +   EAI T NVI+ + P
Sbjct: 15833 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15869



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 38/148 (25%), Positives = 56/148 (37%), Gaps = 23/148 (15%)

Query: 93    AYAAAAVTVL---EPPASDPELQPAER-PLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLT 148
             ++  AAV V    E   S  E++P ER  +P     +     +T      +  GA + L 
Sbjct: 23042 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVT------IRAGASLRLM 23095

Query: 149   CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRIL-AARLPDSGVY 207
                 G P P + W K G+ L              RA      S +L I+      D+G Y
Sbjct: 23096 VSVSGRPPPVITWSKQGIDL------------ASRAIIDTTESYSLLIVDKVNRYDAGKY 23143

Query: 208   VCHARNAHGHAQAGALLQVHQPPESPPA 235
                A N  G   A  L++V+  P   P+
Sbjct: 23144 TIEAENQSGKKSATVLVKVYDTPGPCPS 23171



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 32/110 (29%), Positives = 49/110 (44%), Gaps = 21/110 (19%)

Query: 424 VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDGE-----ELPVIC 472
           +T + P   +  + + VLEG  A     T EA + G       W RDG+      LP + 
Sbjct: 1   MTTQAPTFTQPLQSVVVLEGSTA-----TFEAHISGFPVPEVSWFRDGQVISTSTLPGVQ 55

Query: 473 QSSSGHMHALVLPGVTREDAG----EVTFSLGNSRTTTLLRVKCVKHSPP 518
            S S     L +P VT+ ++G    + T   G + +T  L VK  + +PP
Sbjct: 56  ISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK-AETAPP 104



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 47/196 (23%), Positives = 80/196 (40%), Gaps = 24/196 (12%)

Query: 343 FTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRL----LPCRKYEQIEEGTVRRL 397
           FT+PLQ V   E   A  E  +    +P  +WFR+ Q +    LP  +     +G  +  
Sbjct: 8   FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQI-SFSDGRAKLT 66

Query: 398 IIHRLKADDD--GIYLCEMRGRVRTVANVTVKG----PILKRLPRKLDVLEGENAVLLVE 451
           I    KA+     +      G+  + A + VK     P   +  + + V +G    L V 
Sbjct: 67  IPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVR 126

Query: 452 TLEAGVEG---RWSRDGEELPVICQ---SSSGHMHALVLPGVTREDAG----EVTFSLGN 501
               G+     ++ RDG E+        S  G +++L++     ED+G      T S+G 
Sbjct: 127 V--TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR 184

Query: 502 SRTTTLLRVKCVKHSP 517
           + +T  L V+  +  P
Sbjct: 185 ATSTAELLVQGEEEVP 200



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 22/104 (21%), Positives = 45/104 (43%), Gaps = 2/104 (1%)

Query: 1630 TIVRGPHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPRLRLQALGTRRLLQLR 1688
            TI    HD+ V EG+  +         +  V+W KDG  +  S RL ++       L++ 
Sbjct: 8016 TIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVP 8075

Query: 1689 RCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSARE 1732
            +   +DAG Y+  +   + G    ++  + + +    + + A +
Sbjct: 8076 KSVRADAGIYTITLEN-KLGSATASINVKVIGLPGPCKDIKASD 8118



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 26/112 (23%), Positives = 42/112 (37%), Gaps = 8/112 (7%)

Query: 232  SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR 291
            S    P +   P + P     +   V EG +      + G P P + W ++  P  PD +
Sbjct: 9731 SATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTW-FKAPPKKPDNK 9789

Query: 292  RLMYRDR-------DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
              +  D        D    L +   +  D GLY   A N+ G     ++L+V
Sbjct: 9790 EPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9841



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 2/88 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PG P    +    K  V L W+ P+    +P + Y +ER+  GS+DW +           
Sbjct: 11729 PGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHY 11788

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPHV 604
             +   CV ++  Y FR+ T +  G S  V
Sbjct: 11789 MVDRCVENQ-IYEFRVQTKNEGGESDWV 11815



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%)

Query: 153   GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHAR 212
             G P+PT+ W+K    L +    +          +    S  L I      DSG Y   AR
Sbjct: 14719 GRPKPTVTWKKGDQILKQTQRVNF---------ETTATSTILNINECVRSDSGPYPLTAR 14769

Query: 213   NAHGHAQAGALLQVHQPPESPPADP 237
             N  G       +QVH  P  PP  P
Sbjct: 14770 NIVGEVGDVITIQVHDIP-GPPTGP 14793



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 13/40 (32%), Positives = 20/40 (50%)

Query: 1659  VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
             VTW+K    L  + R+  +   T  +L +  C  SD+G Y
Sbjct: 14725 VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPY 14764



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 15/53 (28%), Positives = 29/53 (54%), Gaps = 1/53 (1%)

Query: 515   HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             + PP PP   E+    K+++++ W  P+    +  I Y +ER++   + WI+C
Sbjct: 15280 YGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKC 15332



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    +N+V L+W+ PE    +  + Y +E Q  GS+ W  C ++ K     
Sbjct: 15677 PLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATV-KVTEAT 15735

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             + G  +  E +Y FR+   +  G S
Sbjct: 15736 ITG-LIQGE-EYSFRVSAQNEKGIS 15758



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 29/107 (27%), Positives = 40/107 (37%), Gaps = 10/107 (9%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G  V L     G P PT+ W KD    D+   ++         +       ++ I  A  
Sbjct: 20515 GTSVKLRAGISGKPAPTIEWYKD----DKELQTNALVCVENTTD-----LASILIKDADR 20565

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
              +SG Y    RNA G A A   +Q+   P  PP  P E      E +
Sbjct: 20566 LNSGCYELKLRNAMGSASATIRVQILDKP-GPPGGPIEFKTVTAEKI 20611



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 18/77 (23%), Positives = 33/77 (42%), Gaps = 1/77 (1%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G   K R  + GKP P IEW+ + + L  +    +    D   +L +      + G Y  
Sbjct: 20515 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL-IKDADRLNSGCYEL 20573

Query: 320   AARNSAGQTLSAVQLHV 336
               RN+ G   + +++ +
Sbjct: 20574 KLRNAMGSASATIRVQI 20590



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/83 (28%), Positives = 29/83 (34%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +GA   L     G P P  VW K    L  S R       +   L +      DAG Y
Sbjct: 21997 VRAGASIRLFIAYQGRPTPTAVWSKPDSNL--SLRADIHTTDSFSTLTVENCNRNDAGKY 22054

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  N +G       V VL+ P
Sbjct: 22055 TLTVENNSGSKSITFTVKVLDTP 22077


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score =  461 bits (1185), Expect = e-129
 Identities = 389/1568 (24%), Positives = 676/1568 (43%), Gaps = 73/1568 (4%)

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
            K   V E + A+F C +    E  + W  +G  ++    +          +L +   Q  
Sbjct: 4996 KDVTVPERRQARFECVLTR--EANVIWS-KGPDIIKSSDKFDIIADGKKHILVINDSQFD 5052

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
            D G+Y        G+  SA +L V   RL+F  PL+D   +E   A   C++ + ++   
Sbjct: 5053 DEGVYTAEVE---GKKTSA-RLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVV 5108

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            WF+ D +L   R      EG   +L +  +  DD    + +++ +V+ +++ T +  +L+
Sbjct: 5109 WFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDD----ISQIKAQVKELSS-TAQLKVLE 5163

Query: 433  RLPRKLDVLEGENAVLLVE-TLEAGVEG----RWSRDGEEL---PVICQSSSGHMHALVL 484
              P     L  + AV   E TL+  V      +W +DGEE+   P     + G    L +
Sbjct: 5164 ADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKI 5223

Query: 485  PGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPA 544
                 +D GE     G  +T   + V+        P    E+F G      +    P+  
Sbjct: 5224 KKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVH 5283

Query: 545  PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
             +    ++L+ Q + +    +     K   + +    +   G+  F+    + + +S   
Sbjct: 5284 GQ----WKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQ----AANAKSAAN 5335

Query: 605  VFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
            +      L+     +  L DV+V++ ++A F  ++S   +   +L G          Q  
Sbjct: 5336 LKVKELPLI----FITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGT---------QEI 5382

Query: 665  PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
             G  R+ + + G +H +++ +   +D    + F       S  L I+   +  L+P   V
Sbjct: 5383 TGDDRFELIKDGTKHSMVIKSAAFEDEAKYM-FEAEDKHTSGKLIIEGIRLKFLTPLKDV 5441

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
              T    E  V T ELS  +    W+K+ Q++  +  + ++ +G+ H +   +  + D+ 
Sbjct: 5442 --TAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTS 5499

Query: 785  EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDG 844
            +      G+S+   +TV +   +     +      +  + V+L CE+ + DAPV+W+KDG
Sbjct: 5500 QIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDG 5557

Query: 845  QEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSG 904
            +E++ S   V++ +G  R L+L     SD G++ C  G +     + I D    +V P  
Sbjct: 5558 KEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLH 5617

Query: 905  KVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLED 964
             V V      R     E+        W   GE ++++P   +++E  +  LVL   +L+ 
Sbjct: 5618 SVEVMETETAR--FETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQ 5675

Query: 965  SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
            +G    +  +  +S  + V    + ++ P  +VT+ A   E     CELS ED PV WY 
Sbjct: 5676 TGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAG--ETATFDCELSYEDIPVEWYL 5733

Query: 1025 DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHP 1084
             G ++E S+ +V   +G    L L   + ED GE    A D      + V  PP     P
Sbjct: 5734 KGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKP 5793

Query: 1085 AARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQ 1144
                 D          L CEV+   ++V+W+K+G E+  S   ++ A+G  R L +    
Sbjct: 5794 LE---DQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCT 5850

Query: 1145 PEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV 1204
            PED   Y C+ +    + N+ +  P V+FL   T    L V   E     CELSR  A V
Sbjct: 5851 PEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTD---LQVREKEMARFECELSRENAKV 5907

Query: 1205 VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
             W  +G  +++G+  ++ ++G  R+L I          Y+C+   A  +  L+   + A 
Sbjct: 5908 KWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEA- 5966

Query: 1265 PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQ 1324
                V     A   V  T    ++LV  +S PG  V WYK  E +   GR ++   G ++
Sbjct: 5967 ----VFTKNLANIEVSETD--TIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKR 6020

Query: 1325 VLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS 1384
            +L +Q A   DAG Y C  P       V V E L  + +S+   L + EG+ A F C +S
Sbjct: 6021 ILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHE-LAAEFISKPQNLEILEGEKAEFVCSIS 6079

Query: 1385 PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHV 1444
                 V W R+   +  G + ++  +G  R+L ++   L D GT  +  G+   +A L V
Sbjct: 6080 KESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV 6139

Query: 1445 RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHI 1504
             E +L  +  L+D R +E Q+V    E    GA    +W R  + +   S+  + Q   +
Sbjct: 6140 IE-KLRIVVPLKDTRVKEQQEVVFNCEVNTEGAKA--KWFRNEEAIFDSSKYIILQKDLV 6196

Query: 1505 HRLFIHGVILADQGTYGCESHHDR-----TLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
            + L I    L DQ  Y     + R     + A L V    LR++ PL+D+   E  S TF
Sbjct: 6197 YTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTF 6256

Query: 1560 QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
              ++++  VT +W + G ++    +     D ++H L +   G  D G    TA   +  
Sbjct: 6257 WCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSV 6316

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
            A L++ E P   V    D  VTE D A F C+LS+  A+V W ++G  +    + + +  
Sbjct: 6317 AELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKD 6376

Query: 1680 GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
            G+   L ++ C   D   Y+C V   R    RL V E  V ++   + +    G    F 
Sbjct: 6377 GSIHRLIIKDCRLDDECEYACGV-EDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFL 6435

Query: 1740 CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA 1799
              +++ +   +W      +  G + ++  EGK H L + +++  D GE RF A   ++ A
Sbjct: 6436 AELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARA 6495

Query: 1800 LLEVEALP 1807
             LE+ A P
Sbjct: 6496 KLELAAAP 6503



 Score =  439 bits (1128), Expect = e-122
 Identities = 392/1575 (24%), Positives = 667/1575 (42%), Gaps = 85/1575 (5%)

Query: 327  QTLSAVQ---LHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPC 383
            Q L+A+    L VKE  L F  PL+DV   E   A  EC V        W +    +   
Sbjct: 4972 QALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC-VLTREANVIWSKGPDIIKSS 5030

Query: 384  RKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLD--VL 441
             K++ I +G    L+I+  + DD+G+Y  E+ G+ +T A + V G  LK +    D  V 
Sbjct: 5031 DKFDIIADGKKHILVINDSQFDDEGVYTAEVEGK-KTSARLFVTGIRLKFMSPLEDQTVK 5089

Query: 442  EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFS 498
            EGE A  + E     +   W ++  +L     +  SS G  H L +  VT +D  ++   
Sbjct: 5090 EGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 5149

Query: 499  LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-----IYRL 553
            +    +T  L+V  ++  P     L +     K+ + L  +  +  P   F     I   
Sbjct: 5150 VKELSSTAQLKV--LEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPS 5207

Query: 554  ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
             +  + ++   +   I+KA         +  +G+Y   +C         +V     A L+
Sbjct: 5208 PKYSIKADGLRRILKIKKAD--------LKDKGEY---VCDCGTDKTKANVTVE--ARLI 5254

Query: 614  PTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRI 672
               + + G+E   V+ GE A F ++LS   + G W L G+ L ++ P+ +         I
Sbjct: 5255 KVEKPLYGVE---VFVGETAHFEIELSEPDVHGQWKLKGQPLTAS-PDCE---------I 5301

Query: 673  EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
             + G +H LILH  +   +G  V F     + +A L ++E P+  ++P   V +     +
Sbjct: 5302 IEDGKKHILILHNCQLGMTGE-VSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKD 5358

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
                 CE+SR      W K  Q++   +   +  DG KH +++  A  +D  ++    E 
Sbjct: 5359 EAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAED 5418

Query: 793  VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDF 852
                  + ++   +  + P + V   A   E  +   E+  ++  V+W+K+ Q +  +  
Sbjct: 5419 KHTSGKLIIEGIRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRS 5476

Query: 853  VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVY-VAAV 911
            V +++EG    +        D  + +  A    +   +T+ +      Y +GK+     V
Sbjct: 5477 VSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDP---YFTGKLQDYTGV 5533

Query: 912  RLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCE 971
              + V+L CE+ +  A V+W KDG+E+  S   +++ +   R L+L      D G+Y C+
Sbjct: 5534 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 5593

Query: 972  IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEE 1031
               +  S  + + +  ++++ P   V ++    E      E+S +D    W   G  + +
Sbjct: 5594 CGTDKTSGKLDIEDREIKLVRPLHSVEVMET--ETARFETEISEDDIHANWKLKGEALLQ 5651

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDL 1091
            +    ++ +G    LVL   + +  G     A +  +   + V      ++ P     D+
Sbjct: 5652 TPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLK---DV 5708

Query: 1092 HFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
               A       CE++     V WY  G ++E SD +   +EG   TLTL   + EDAGE 
Sbjct: 5709 TVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEV 5768

Query: 1152 VCETRHEAITFNVILAEPPVQFLALETTP-SPLCVAPGEPVVLSCELSRAGAPVVWSHNG 1210
                +      N+ + EPPV+F    T P     V  G   VL CE+SR  A V W  NG
Sbjct: 5769 QLTAKDFKTHANLFVKEPPVEF----TKPLEDQTVEEGATAVLECEVSRENAKVKWFKNG 5824

Query: 1211 RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVV 1270
              + + +  E+ A+G  R L I    P     YTC +         S  + V  P V  +
Sbjct: 5825 TEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDF----KTSCNLNVVPPHVEFL 5880

Query: 1271 APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
             P     +VR       E    LS     V+W+KDG  +    +  +   GA ++L +  
Sbjct: 5881 RP-LTDLQVREKEMARFEC--ELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINK 5937

Query: 1331 ARSGDAGEYLCDA--PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA 1388
                D  EY C+    + S +  V  EE +  K    L  + V E D     CEVS P A
Sbjct: 5938 CLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTK---NLANIEVSETDTIKLVCEVSKPGA 5994

Query: 1389 DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETE 1448
            +V W +    +    + E+   G  RIL ++   L DAG    R  S+ T  ++ V E  
Sbjct: 5995 EVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELA 6054

Query: 1449 LLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLF 1508
              F+ + Q++   EG+         +   +  V+W R  + L    +  +  DG    L 
Sbjct: 6055 AEFISKPQNLEILEGEKAEFVCSISK--ESFPVQWKRDDKTLESGDKYDVIADGKKRVLV 6112

Query: 1509 IHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
            +    L D GTY       R  A L+V  + LR++ PL+D  + E     F  E++ EG 
Sbjct: 6113 VKDATLQDMGTYVVMVGAARAAAHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGA 6171

Query: 1569 TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGC--VSFT---ADSLRCAARLI 1623
              +W R    ++   K  I      + L +    L D     VS T    ++++ AA LI
Sbjct: 6172 KAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLI 6231

Query: 1624 VREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRR 1683
            V E  + IV    D+E  E  + TF C++++    + W K+G  +    R+  +    + 
Sbjct: 6232 VEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKH 6291

Query: 1684 LLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVS 1743
            +L ++ CG  D G Y    G  ++    L + E     +  L   +  E D A F C +S
Sbjct: 6292 MLTIKDCGFPDEGEYIVTAGQDKS-VAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLS 6350

Query: 1744 EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEV 1803
              +   +W   GR ++ G + +  ++G  H L++ + R +D  E        +S A L V
Sbjct: 6351 REKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFV 6410

Query: 1804 EALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTH 1863
            E +P+++ R PP++     G   V    +++    V WLR    +  GDK++M S G  H
Sbjct: 6411 EEIPVEIIR-PPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIH 6469

Query: 1864 SLVIHDVRPEDQGTY 1878
             L I D++P DQG Y
Sbjct: 6470 RLQICDIKPRDQGEY 6484



 Score =  394 bits (1013), Expect = e-109
 Identities = 402/1699 (23%), Positives = 685/1699 (40%), Gaps = 129/1699 (7%)

Query: 228  QPPESPPADPDEAPAPVVEPLKCAPKTFWVNE------------GKHAKFRCYVMGKPEP 275
            +P       PDEAP      LK  P  F V E            G  A F C V   P  
Sbjct: 4595 RPGSGGEKPPDEAP--FTYQLKAVPLKF-VKEIKDIILTESEFVGSSAIFECLV--SPST 4649

Query: 276  EIE-WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             I  W  +G  +    +     D      L ++  Q  D G Y C  R    +  S  +L
Sbjct: 4650 AITTWMKDGSNIRESPKHRFIADGKDR-KLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKL 4708

Query: 335  HVKEPRLRFTRPLQD----VEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
             V+E  +RF + L++    V+G+      L C++ N      W R+D +++   K  +I 
Sbjct: 4709 VVEELPVRFVKTLEEEVTVVKGQP---LYLSCEL-NKERDVVW-RKDGKIV-VEKPGRIV 4762

Query: 391  EGTV---RRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-----GPILKRLPRKLDVLE 442
             G +   R L I+     D G Y   +        +  VK        L +  R   V  
Sbjct: 4763 PGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKP 4822

Query: 443  GENAVLLVETLEAGVEGRWSRDGEELPVICQSSS-----GHMHALVLPGVTREDAGEVTF 497
               A+   +  +     +W +  +E+P      +     G+   L +     ED  E   
Sbjct: 4823 KGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAV 4882

Query: 498  SLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLER-- 555
             +   R                    A++  G +   LL  KP E       IY  E   
Sbjct: 4883 EIEGKRYP------------------AKLTLGEREVELL--KPIEDVT----IYEKESAS 4918

Query: 556  --QEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLV 613
               E+   D    + ++       P   + +EG  RF         ++  V++  + + +
Sbjct: 4919 FDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQ-ALNAI 4977

Query: 614  PTARL---------VAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
             TA L            L+DV V +   A F   L+      W    + +KS++      
Sbjct: 4978 TTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTREANVIWSKGPDIIKSSD------ 5031

Query: 665  PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRV 724
                ++ I   G +H L+++  +  D G        G + SA L +    +  +SP +  
Sbjct: 5032 ----KFDIIADGKKHILVINDSQFDDEGVYTA-EVEGKKTSARLFVTGIRLKFMSPLE-- 5084

Query: 725  SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
              T    E     CELS       W+K+  K+  S  +++  +G+ H+L + E  + D  
Sbjct: 5085 DQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDIS 5144

Query: 785  EFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH---AITSECVMLACEVDREDAPVRWY 841
            + + + + +S+   + V +      DP   V +H   A+  + + L CEV + D PV+W+
Sbjct: 5145 QIKAQVKELSSTAQLKVLE-----ADPYFTVKLHDKTAVEKDEITLKCEVSK-DVPVKWF 5198

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            KDG+E+  S    ++ +G  R L +      D GE+ C  G +     VT   V + ++ 
Sbjct: 5199 KDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVT---VEARLIK 5255

Query: 902  PSGKVYVAAVRL-ERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAV 960
                +Y   V + E      EL  P    +W   G+ +  SP   + ++     L+L   
Sbjct: 5256 VEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNC 5315

Query: 961  QLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV 1020
            QL  +GE   +  +  ++  + V E P+  I P  +V +     +     CE+SRE    
Sbjct: 5316 QLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVF--EKDEAKFECEVSREPKTF 5373

Query: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
            RW K   E+   +   L +DG +  +V+ +A  ED  +++ +A D      + +     +
Sbjct: 5374 RWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLK 5433

Query: 1081 IVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140
             + P     D+            E++    +V+W+K+   +  + ++ +  EG T ++T 
Sbjct: 5434 FLTPLK---DVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITF 5490

Query: 1141 PHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 1200
                 +D  +   E    +    + + E    F               + V+L CE+S+A
Sbjct: 5491 KDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTG---KLQDYTGVEKDEVILQCEISKA 5547

Query: 1201 GAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTV 1260
             APV W  +G+ ++  +   + A+G +R+L ++ A  +  G YTC      G    S  +
Sbjct: 5548 DAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDC----GTDKTSGKL 5603

Query: 1261 QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA 1320
             + +  +++V P      V  T     E    +S       W   GE L      ++++ 
Sbjct: 5604 DIEDREIKLVRP-LHSVEVMETETARFE--TEISEDDIHANWKLKGEALLQTPDCEIKEE 5660

Query: 1321 GARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
            G    L +   R    G     A        + V +P ++ L+  L  +TV  G+ ATF 
Sbjct: 5661 GKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRV-KPRVIGLLRPLKDVTVTAGETATFD 5719

Query: 1381 CEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA 1440
            CE+S  D  V W   G  + P  +V     G    LTLR  +L DAG V L A    T A
Sbjct: 5720 CELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHA 5779

Query: 1441 RLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQ 1500
             L V+E  + F + L+D   EEG    LE E  R  A   V+W + G  +    +  +  
Sbjct: 5780 NLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA--KVKWFKNGTEILKSKKYEIVA 5837

Query: 1501 DGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ 1560
            DG + +L IH     D  TY C++   +T   L+V P  +  LRPL D+ + E   A F+
Sbjct: 5838 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFE 5897

Query: 1561 LELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAA 1620
             ELS+E    +W + G ++  G K  I S G    LV+N   L D    S    + R + 
Sbjct: 5898 CELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSG 5957

Query: 1621 RLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALG 1680
             L V E      +   ++EV+E DT    CE+S+  A+V W K    +  + R  +   G
Sbjct: 5958 MLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEG 6017

Query: 1681 TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC 1740
             +R+L ++     DAG Y+C + ++R    ++ V E     +S+ +++   EG+ A F C
Sbjct: 6018 RKRILVIQNAHLEDAGNYNCRLPSSRTDG-KVKVHELAAEFISKPQNLEILEGEKAEFVC 6076

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLA- 1799
            ++S+     +W+   + L  G +  +  +GKK +LV+ +   +D G      G A++ A 
Sbjct: 6077 SISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAH 6136

Query: 1800 LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSH 1859
            L  +E L + +   P ++  V   +  V    V+  G    W R    +    KY +   
Sbjct: 6137 LTVIEKLRIVV---PLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQK 6193

Query: 1860 GPTHSLVIHDVRPEDQGTY 1878
               ++L I D   +DQ  Y
Sbjct: 6194 DLVYTLRIRDAHLDDQANY 6212



 Score =  385 bits (988), Expect = e-106
 Identities = 420/1813 (23%), Positives = 709/1813 (39%), Gaps = 111/1813 (6%)

Query: 105  PASDPELQPAERP-------LPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
            P S  E  P E P       +P     E   + LT   S++V  G+  +  C        
Sbjct: 4596 PGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILT--ESEFV--GSSAIFECLVSPSTAI 4651

Query: 158  TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
            T  W KDG  + E          P       G    L I+  +L D+G Y C  R  +  
Sbjct: 4652 TT-WMKDGSNIRE---------SPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKE 4701

Query: 218  AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
              + A L V + P              V  +K   +   V +G+     C +    E ++
Sbjct: 4702 KTSTAKLVVEELP--------------VRFVKTLEEEVTVVKGQPLYLSCEL--NKERDV 4745

Query: 278  EWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             W  +G+ ++    R++         L +      D G Y     N+     S+    V+
Sbjct: 4746 VWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVE 4805

Query: 338  EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFR--EDQRLLPCRKYEQIEEGTVR 395
              R    +P++D   +  G A+  C +        WF+  ++    P  K E + +G   
Sbjct: 4806 VIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHL 4865

Query: 396  RLIIHRLKADDDGIYLCEMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVET 452
             L I     +D   Y  E+ G+ R  A +T+   +  +LK +   + + E E+A    E 
Sbjct: 4866 YLKIKNAMPEDIAEYAVEIEGK-RYPAKLTLGEREVELLKPI-EDVTIYEKESASFDAEI 4923

Query: 453  LEAGVEGRWSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLR 509
             EA + G+W   GE L   P     + G    L L  V  + AGEV +   N+ TT +L 
Sbjct: 4924 SEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILT 4983

Query: 510  VKCVK--HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCF 567
            VK ++   + P   +     +  +   +LT        E   I+      + S D     
Sbjct: 4984 VKEIELDFAVPLKDVTVPERRQARFECVLT-------REANVIWSKGPDIIKSSDKFDII 5036

Query: 568  SIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQV 627
            +  K   + +       EG Y      V G   S  +   G        + ++ LED  V
Sbjct: 5037 ADGKKHILVINDSQFDDEGVYT---AEVEGKKTSARLFVTGIR-----LKFMSPLEDQTV 5088

Query: 628  YDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
             +GE A F  +LS   +   WF N  +L ++              I  +G  H+L +  V
Sbjct: 5089 KEGETATFVCELSHEKMHVVWFKNDAKLHTSRT----------VLISSEGKTHKLEMKEV 5138

Query: 687  KHQDSGALVGFSCPGVQDSAALTIQES-PVHILSPQDRVSLTFTTSERVVLTCELSRVDF 745
               D   +       +  +A L + E+ P   +   D+   T    + + L CE+S+ D 
Sbjct: 5139 TLDDISQIKA-QVKELSSTAQLKVLEADPYFTVKLHDK---TAVEKDEITLKCEVSK-DV 5193

Query: 746  PATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPP 805
            P  W+KDG+++  S    +K DG +  L + +A ++D GE+ C          VTV+   
Sbjct: 5194 PVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARL 5253

Query: 806  VHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLV 865
            + +  P   V V     E      E+   D   +W   GQ +  S    +  +G    L+
Sbjct: 5254 IKVEKPLYGVEV--FVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILI 5311

Query: 866  LPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRP 925
            L   Q    GE    A +  +   + + ++    + P   V V     +     CE+ R 
Sbjct: 5312 LHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKV--FEKDEAKFECEVSRE 5369

Query: 926  WAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTE 985
                RW K  +E+       L K+ T   +V+ +   ED  +Y+ E +D+  S  + +  
Sbjct: 5370 PKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEG 5429

Query: 986  PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCR 1045
              ++ + P  +VT  A   E  V   ELS ++  V+W+K+   +  + ++ ++ +G    
Sbjct: 5430 IRLKFLTPLKDVT--AKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 5487

Query: 1046 LVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEV 1105
            +       +D  +   +A   S+   +TV    E   +   +  D        V L+CE+
Sbjct: 5488 ITFKDLSIDDTSQIRVEAMGMSSEAKLTVL---EGDPYFTGKLQDYTGVEKDEVILQCEI 5544

Query: 1106 APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVI 1165
            + A + V+W+KDG E++ S    + A+G  R L L  A   D G+Y C+   +  +  + 
Sbjct: 5545 SKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLD 5604

Query: 1166 LAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEG 1225
            + +  ++   L      + V   E      E+S       W   G  + +    E+  EG
Sbjct: 5605 IEDREIK---LVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEG 5661

Query: 1226 PRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGG 1285
                L +        G      G    A ++  +  +   P RV+        V  T G 
Sbjct: 5662 KIHSLVLHNCRLDQTG------GVDFQAANVKSSAHLRVKP-RVIGLLRPLKDVTVTAGE 5714

Query: 1286 DLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQ 1345
                   LS    PV WY  G++L    +V     G    L ++  +  DAGE    A  
Sbjct: 5715 TATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD 5774

Query: 1346 DSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQV 1405
                  + V+EP  V+    L   TV EG  A   CEVS  +A V W +NG  +    + 
Sbjct: 5775 FKTHANLFVKEPP-VEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKY 5833

Query: 1406 EMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQD 1465
            E+  +G  R L +  C   D  T T  A    TS  L+V    + FLR L D++  E + 
Sbjct: 5834 EIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEM 5893

Query: 1466 VCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESH 1525
               E E  R  A   V+W + G  +    +  +   G +  L I+  +L D+  Y CE  
Sbjct: 5894 ARFECELSRENAK--VKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR 5951

Query: 1526 HDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKC 1585
              RT   L+V   +    + L ++ +SE  +     E+S+ G    W +G  ++    + 
Sbjct: 5952 TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRY 6011

Query: 1586 HIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT 1645
             I ++G +  LV+    L D+G  +    S R   ++ V E+    +  P +LE+ EG+ 
Sbjct: 6012 EILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEK 6071

Query: 1646 ATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTA 1705
            A F C +S+    V W++D   L    +  + A G +R+L ++     D GTY   VG A
Sbjct: 6072 AEFVCSISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAA 6131

Query: 1706 RAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVR 1765
            RA    LTV E+ + ++  L+    +E     F C V+      +W      +   ++  
Sbjct: 6132 RAA-AHLTVIEK-LRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYI 6189

Query: 1766 IRQEGKKHILVLSELRAEDAGE-----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTV 1820
            I Q+   + L + +   +D           +    +S A L VE   L++   P ++   
Sbjct: 6190 ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIV-EPLKDIET 6248

Query: 1821 LVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC 1880
            +  +       V+R    + W + G E+   ++   R     H L I D    D+G Y  
Sbjct: 6249 MEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIV 6308

Query: 1881 QAGQDSTHTRLLV 1893
             AGQD +   LL+
Sbjct: 6309 TAGQDKSVAELLI 6321



 Score =  380 bits (975), Expect = e-105
 Identities = 317/1277 (24%), Positives = 523/1277 (40%), Gaps = 41/1277 (3%)

Query: 622  LEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRL 681
            L D    + ++     ++S  +   WF +GEE+  +           +Y I+  GL+  L
Sbjct: 5172 LHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSP----------KYSIKADGLRRIL 5221

Query: 682  ILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELS 741
             +     +D G  V   C   +  A +T++   + +  P   V +     E      ELS
Sbjct: 5222 KIKKADLKDKGEYV-CDCGTDKTKANVTVEARLIKVEKPLYGVEVF--VGETAHFEIELS 5278

Query: 742  RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTV 801
              D    W   GQ +  S    +  DG+KH LIL   ++  +GE   +     +   + V
Sbjct: 5279 EPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKV 5338

Query: 802  QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPH 861
            ++ P+  + P   V V     +     CEV RE    RW K  QE+   D   L  +G  
Sbjct: 5339 KELPLIFITPLSDVKV--FEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTK 5396

Query: 862  RRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCE 921
              +V+ +    D  ++   A D+     + I  +    + P   V   A   E  V T E
Sbjct: 5397 HSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDV--TAKEKESAVFTVE 5454

Query: 922  LCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTV 981
            L      V+W K+ + +  + ++ +Q E     +    + ++D+ +   E    S+   +
Sbjct: 5455 LSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKL 5514

Query: 982  TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
            TV E          + T   V  + V+L CE+S+ DAPV+W+KDG E++ S+  V++ DG
Sbjct: 5515 TVLEGDPYFTGKLQDYT--GVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADG 5572

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             +  L+L  A   D G++ CD G D     + +     ++V P   S+++      R E 
Sbjct: 5573 KKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPL-HSVEVMETETARFET 5631

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
              E++       W   G  +  +   ++  EG   +L L + + +  G    +  +   +
Sbjct: 5632 --EISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSS 5689

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLEL 1221
             + +  +P V  + L      + V  GE     CELS    PV W   G+ ++  + +  
Sbjct: 5690 AH-LRVKPRV--IGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVP 5746

Query: 1222 HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRS 1281
             +EG    L ++      AG     +       +L     V EPPV    P   QT    
Sbjct: 5747 RSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----VKEPPVEFTKPLEDQT---V 5799

Query: 1282 TPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
              G    L   +S     V+W+K+G  +    + ++   G  + L +      D   Y C
Sbjct: 5800 EEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC 5859

Query: 1342 DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP 1401
            DA        ++V  P  V+ +  LT L V E + A F CE+S  +A V W ++GA +  
Sbjct: 5860 DAKDFKTSCNLNVVPPH-VEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKK 5918

Query: 1402 GPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAE 1461
            G + ++   G+ RIL +  C L D    +    +  TS  L V E E +F + L ++   
Sbjct: 5919 GKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVS 5978

Query: 1462 EGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYG 1521
            E   + L  E  + GA   V W +G + +    R  +  +G    L I    L D G Y 
Sbjct: 5979 ETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYN 6036

Query: 1522 CESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
            C     RT  ++ V       +   +++ I EG  A F   +S+E    +W R    L  
Sbjct: 6037 CRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLES 6096

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
            G K  + +DG +  LV+    L D G       + R AA L V E  + IV    D  V 
Sbjct: 6097 GDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK 6155

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA 1701
            E     F CE++   A   W ++  A+  S +  +        L++R     D   Y+ +
Sbjct: 6156 EQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVS 6215

Query: 1702 VGTARAGPVR----LTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRP 1757
            +   R   V+    L V E  + ++  L+ +   E    TF C V+ +  T +W   G  
Sbjct: 6216 LTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEE 6275

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            +    RV  R +  KH+L + +    D GE    AG  +S+A L +   P +   H   +
Sbjct: 6276 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHL-ED 6334

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
            +TV     AV    +SR   +V W R G E+  G KY+    G  H L+I D R +D+  
Sbjct: 6335 QTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECE 6394

Query: 1878 YCCQAGQDSTHTRLLVE 1894
            Y C      +  RL VE
Sbjct: 6395 YACGVEDRKSRARLFVE 6411



 Score =  371 bits (952), Expect = e-102
 Identities = 397/1661 (23%), Positives = 670/1661 (40%), Gaps = 102/1661 (6%)

Query: 276  EIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKD-RGLYVCAARNSAGQTLSAVQL 334
            E+ W++E + L+P   +         + L +     +D +G YVC A N +G+T ++ +L
Sbjct: 4271 EVNWYFENK-LVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKL 4329

Query: 335  H-VKEPRLRFTRPLQDVEGREHGIAVLECKV---PNSRIPTAWFREDQRLLPCRKYEQIE 390
              VK       R ++ +E     +A   C++   PN R    WF+  + +    K     
Sbjct: 4330 TVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRF--QWFKAGREIYESDKCSIRS 4387

Query: 391  EGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVANVTVKGP-----ILKRLPRKLDVLE 442
               +  L I R +  D G Y C+     G V   A +TV  P     + K LP +    E
Sbjct: 4388 SKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPERKP--E 4445

Query: 443  GENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLP-GVTREDAGEVTFSLGN 501
             +  V+L   L         R  EE P +       +    +P     +   EV      
Sbjct: 4446 PKEEVVLKSVLR-------KRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVT 4498

Query: 502  SRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE-TPFIYRLERQEVGS 560
             R   +     V    P  P+ A   K      + T KPP   PE TP    +    VG 
Sbjct: 4499 KRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGK 4558

Query: 561  EDWIQCFSIEKA---GAVEVPGDCVPSEGDYRFRICTVSGHGRSP--HVVFHGSAHLVPT 615
            +   +    E A   G ++      PS  +   R       G  P     F      VP 
Sbjct: 4559 KAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAVP- 4617

Query: 616  ARLVAGLEDV----QVYDGEDAVFS--LDLSTIIQGTWFLNGEELKSNEPEGQVEPGALR 669
             + V  ++D+      + G  A+F   +  ST I  TW  +G  ++ +           +
Sbjct: 4618 LKFVKEIKDIILTESEFVGSSAIFECLVSPSTAIT-TWMKDGSNIRESP----------K 4666

Query: 670  YRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD---SAALTIQESPVHILSPQDRVSL 726
            +R    G   +L +  V+  D+G        G ++   +A L ++E PV  +   +   +
Sbjct: 4667 HRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEE-EV 4725

Query: 727  TFTTSERVVLTCELSRVDFPATWYKDGQ-KVEESELLVVKMDGRKHRLILPEAKVQDSGE 785
            T    + + L+CEL++ +    W KDG+  VE+   +V  + G    L + +A   D+G 
Sbjct: 4726 TVVKGQPLYLSCELNK-ERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGT 4784

Query: 786  FECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECV------MLACEVDREDAPVR 839
            +    E  +     +     V +V+      V  I  + V      + AC++ ++   ++
Sbjct: 4785 YTVTVENANNLECSSC----VKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIK 4840

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+K   E+  E +D   +  +G H  L +    P D  E+      +     +T+ +   
Sbjct: 4841 WFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREV 4900

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             ++ P   V +     E      E+       +W   GE +  SP   ++ E   R L L
Sbjct: 4901 ELLKPIEDVTI--YEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTL 4958

Query: 958  PAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTL---IAVTLECVVLMCELS 1014
              V+L+ +GE L +  +   +  +TV E  +    P  +VT+        ECV     L+
Sbjct: 4959 HKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECV-----LT 5013

Query: 1015 REDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV 1074
            RE A V W K    ++ S+   +  DG +  LV+  +Q +D G +  +         + V
Sbjct: 5014 RE-ANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFV 5072

Query: 1075 TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGP 1134
            T    + + P     D            CE++     V W+K+  ++  S  + + +EG 
Sbjct: 5073 TGIRLKFMSPLE---DQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGK 5129

Query: 1135 TRTLTLPHAQPEDAGEYVCETRHEAIT--FNVILAEPPVQFLALETTPSPLCVAPGEPVV 1192
            T  L +     +D  +   + +  + T    V+ A+P       + T         + + 
Sbjct: 5130 THKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKT-----AVEKDEIT 5184

Query: 1193 LSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPG 1252
            L CE+S+   PV W  +G  +       + A+G RR+L I+ A     G Y C  G    
Sbjct: 5185 LKCEVSK-DVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGT--D 5241

Query: 1253 APSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQ 1312
                + TV+      R++  E     V    G      + LS P    +W   G+ L + 
Sbjct: 5242 KTKANVTVE-----ARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTAS 5296

Query: 1313 GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVH 1372
               ++ + G + +L +   + G  GE    A        + V+E  L+  ++ L+ + V 
Sbjct: 5297 PDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLI-FITPLSDVKVF 5355

Query: 1373 EGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
            E D+A F CEVS       WL+    +T   + E+ ++G+   + ++     D       
Sbjct: 5356 EKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFE 5415

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
            A    TS +L +    L FL  L+DV A+E +     VE         V+W +  Q L  
Sbjct: 5416 AEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDNI--RVKWFKNDQRLHT 5473

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTIS 1552
               +SM  +G  H +    + + D      E+    + A+L+V          L+D T  
Sbjct: 5474 TRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYTGV 5533

Query: 1553 EGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFT 1612
            E      Q E+S+     +W + G ++ P     I +DG +  L+L     +D G  +  
Sbjct: 5534 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD 5593

Query: 1613 ADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSP 1672
              + + + +L + +  + +VR  H +EV E +TA FE E+S+      W+  G AL  +P
Sbjct: 5594 CGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTP 5653

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSARE 1732
               ++  G    L L  C     G         ++    L V+ R + +L  L+ V+   
Sbjct: 5654 DCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSS-AHLRVKPRVIGLLRPLKDVTVTA 5712

Query: 1733 GDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA 1792
            G+ ATF+C +S  +    W L G+ L P  +V  R EGK H L L +++ EDAGEV+  A
Sbjct: 5713 GETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTA 5772

Query: 1793 GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGD 1852
               ++ A L V+  P++  + P  ++TV  G  AVLE  VSR    V W + G E+    
Sbjct: 5773 KDFKTHANLFVKEPPVEFTK-PLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSK 5831

Query: 1853 KYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            KYE+ + G    LVIHD  PED  TY C A    T   L V
Sbjct: 5832 KYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV 5872



 Score =  349 bits (896), Expect = 1e-95
 Identities = 341/1251 (27%), Positives = 528/1251 (42%), Gaps = 98/1251 (7%)

Query: 701  GVQDSAALTIQESPVHILS---PQDRVSLTFTTSER---VVLTCELSRVDFPATWYKDGQ 754
            G ++ A + IQE+   ++    P     L  T SE    V LT  ++       WY + +
Sbjct: 4221 GTEEVATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSITNAK-EVNWYFENK 4279

Query: 755  KVEESELLVVKMDGRKHRLILPEAKVQD-SGEFECRT------EGVSAFFGVTVQDPPV- 806
             V   E      D   + L++ +   +D  GE+ C           SA   V  +  PV 
Sbjct: 4280 LVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVI 4339

Query: 807  -HIVDPREHVFVHAITSECVMLACEVDREDAP---VRWYKDGQEVEESDFVVLENEGPHR 862
               ++P E    H          CE+  + AP    +W+K G+E+ ESD   + +     
Sbjct: 4340 KRKIEPLEVALGHL-----AKFTCEI--QSAPNVRFQWFKAGREIYESDKCSIRSSKYIS 4392

Query: 863  RLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLER------- 915
             L +  TQ  D GE+ C A +E    + T T     +  P G+  V  +  ER       
Sbjct: 4393 SLEILRTQVVDCGEYTCKASNEYGSVSCTATLT---VTVPGGEKKVRKLLPERKPEPKEE 4449

Query: 916  VVLTCELCR------PWAEVRWTKDGE-------------EVVESPALLLQK----EDTV 952
            VVL   L +      P  E +  +  +             E VE P +  ++    E T 
Sbjct: 4450 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTK 4509

Query: 953  RRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
               + PA+ L  + E   + + E  +      EP    I     V ++    E      E
Sbjct: 4510 VPEIKPAIPLP-APEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEE 4568

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTV 1072
             ++   P++    G+  +    +  ER   R         P  GGE       D A FT 
Sbjct: 4569 AAKPKGPIK----GVPKKTPSPIEAERRKLR---------PGSGGE----KPPDEAPFTY 4611

Query: 1073 TVTAPPERIVHPAARSLDLHFGAPGRVEL-RCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
             + A P + V      +       G   +  C V+P+ +   W KDG  +  S   +  A
Sbjct: 4612 QLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIA 4671

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETR----HEAITFNVILAEPPVQFLALETTPSPLCVAP 1187
            +G  R L +   Q  DAGEY C  R     +  T  +++ E PV+F+  +T    + V  
Sbjct: 4672 DGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFV--KTLEEEVTVVK 4729

Query: 1188 GEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAE-GPRRVLCIQAAGPAHAGLYTCQ 1246
            G+P+ LSCEL++    VVW  +G+ V E  G  +    G  R L I  A    AG YT  
Sbjct: 4730 GQPLYLSCELNKE-RDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVT 4788

Query: 1247 SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
               A      S  V+V E     +        V+  P G       ++     ++W+K  
Sbjct: 4789 VENANNL-ECSSCVKVVEVIRDWLVKPIRDQHVK--PKGTAIFACDIAKDTPNIKWFKGY 4845

Query: 1307 ERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVS 1364
            + + ++   + ++ + G    L+++ A   D  EY  +         +++ E   V+L+ 
Sbjct: 4846 DEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGERE-VELLK 4904

Query: 1365 ELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             +  +T++E + A+F  E+S  D    W   G ++ P P  E+   G  R LTL   +L 
Sbjct: 4905 PIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLD 4964

Query: 1425 DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWV 1484
             AG V  +A +  T+A L V+E EL F   L+DV   E +    E    R      V W 
Sbjct: 4965 QAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTR---EANVIWS 5021

Query: 1485 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            +G   +    +  +  DG  H L I+     D+G Y  E    +T ARL V   +L+ + 
Sbjct: 5022 KGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIRLKFMS 5081

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLA 1604
            PLED T+ EG +ATF  ELS E +   W +   +L+      I S+G  H+L +  + L 
Sbjct: 5082 PLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLD 5141

Query: 1605 DSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKD 1664
            D   +      L   A+L V E         HD    E D  T +CE+S+ +  V W KD
Sbjct: 5142 DISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVP-VKWFKD 5200

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
            G  + PSP+  ++A G RR+L++++    D G Y C  GT +     +TV  R + V   
Sbjct: 5201 GEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKT-KANVTVEARLIKVEKP 5259

Query: 1725 LRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAED 1784
            L  V    G+ A FE  +SE +  G+W+L G+PL       I ++GKKHIL+L   +   
Sbjct: 5260 LYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGM 5319

Query: 1785 AGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLRE 1844
             GEV FQA  A+S A L+V+ LPL     P  +  V     A  E  VSR      WL+ 
Sbjct: 5320 TGEVSFQAANAKSAANLKVKELPLIFIT-PLSDVKVFEKDEAKFECEVSREPKTFRWLKG 5378

Query: 1845 GAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
              E+   D++E+   G  HS+VI     ED+  Y  +A    T  +L++EG
Sbjct: 5379 TQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEG 5429



 Score =  315 bits (807), Expect = 3e-85
 Identities = 253/996 (25%), Positives = 429/996 (43%), Gaps = 47/996 (4%)

Query: 917  VLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI---- 972
            +  C +    A   W KDG  + ESP      +   R+L +  VQL D+GEY C +    
Sbjct: 4640 IFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGN 4699

Query: 973  DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDG-LEVEE 1031
             +++++  + V E PVR +   +E   + V  + + L CEL++E   V W KDG + VE+
Sbjct: 4700 KEKTSTAKLVVEELPVRFVKTLEEEVTV-VKGQPLYLSCELNKE-RDVVWRKDGKIVVEK 4757

Query: 1032 SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGD----DSAFFTVTVTAPPERIVHPAAR 1087
               +V    G    L +  A   D G +     +    + +     V    + +V P   
Sbjct: 4758 PGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIR- 4816

Query: 1088 SLDLHFGAPGRVELRCEVAPAGSQVRWYK--DGLEVEASDALQLGAEGPTRTLTLPHAQP 1145
              D H    G     C++A     ++W+K  D +  E +D  ++  +G    L + +A P
Sbjct: 4817 --DQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMP 4874

Query: 1146 EDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV 1205
            ED  EY  E   +     + L E  V+ L        + +   E      E+S A  P  
Sbjct: 4875 EDIAEYAVEIEGKRYPAKLTLGEREVELL---KPIEDVTIYEKESASFDAEISEADIPGQ 4931

Query: 1206 WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG--LYTCQSGAAPGAPSL-SFTVQV 1262
            W   G  ++     E+ AEG +R L +       AG  LY   +       ++    +  
Sbjct: 4932 WKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDF 4991

Query: 1263 AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
            A P   V  PE  Q R       +  ++           W K  + + S  +  +   G 
Sbjct: 4992 AVPLKDVTVPERRQARFECVLTREANVI-----------WSKGPDIIKSSDKFDIIADGK 5040

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
            + +L +  ++  D G Y  +       +R+F+  +     +K +S L   TV EG+ ATF
Sbjct: 5041 KHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGETATF 5096

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATS 1439
             CE+S     V W +N A +     V ++  G +  L ++   L D   +  +    +++
Sbjct: 5097 VCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSST 5156

Query: 1440 ARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMA 1499
            A+L V E +  F  +L D  A E  ++ L+ E   V     V+W + G+ +    + S+ 
Sbjct: 5157 AQLKVLEADPYFTVKLHDKTAVEKDEITLKCE---VSKDVPVKWFKDGEEIVPSPKYSIK 5213

Query: 1500 QDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATF 1559
             DG    L I    L D+G Y C+   D+T A ++V  R ++V +PL  V +  G +A F
Sbjct: 5214 ADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHF 5273

Query: 1560 QLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
            ++ELS+  V G+W   G  L   P C I  DG +H L+L+   L  +G VSF A + + A
Sbjct: 5274 EIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA 5333

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQAL 1679
            A L V+E+P+  +    D++V E D A FECE+S+      W K    +T   R  L   
Sbjct: 5334 ANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKD 5393

Query: 1680 GTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFE 1739
            GT+  + ++     D   Y            +L +    +  L+ L+ V+A+E + A F 
Sbjct: 5394 GTKHSMVIKSAAFEDEAKYMFEAEDKHTSG-KLIIEGIRLKFLTPLKDVTAKEKESAVFT 5452

Query: 1740 CTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA-GPAQSL 1798
              +S      +W    + L     V ++ EGK H +   +L  +D  ++R +A G +   
Sbjct: 5453 VELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 5512

Query: 1799 ALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRS 1858
             L  +E  P    +   ++ T +     +L+  +S++   V W ++G E+ P     +++
Sbjct: 5513 KLTVLEGDPYFTGK--LQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKA 5570

Query: 1859 HGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             G    L++      D G Y C  G D T  +L +E
Sbjct: 5571 DGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIE 5606



 Score =  291 bits (745), Expect = 4e-78
 Identities = 315/1294 (24%), Positives = 508/1294 (39%), Gaps = 122/1294 (9%)

Query: 674  QKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA-LTIQESPVHILSPQDRVSLTFTTSE 732
            +KGLQ    L  + H+  GAL G +    +     + +   PV +L             E
Sbjct: 1764 RKGLQRIEELERMAHE--GALTGVTTDQKEKQKPDIVLYPEPVRVLE-----------GE 1810

Query: 733  RVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE 791
                 C ++    P   WY +GQ + +S+   V+ DG  H L + + K  D+GE +   E
Sbjct: 1811 TARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGEVKVTAE 1869

Query: 792  GVSAFFGVTVQDPPVHIV-------------DPREHVFVHAITSECVMLACEVDREDAPV 838
                  GV      + I              +PR    VH    E   L  EV + D PV
Sbjct: 1870 NPE---GVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVH----EPGKLQFEVQKVDRPV 1922

Query: 839  -----------------RWYKDGQEVEE--SDFVVLENEGPHRRLV---LPATQPSDG-G 875
                                K  +E EE  S F     EG +  +    L + +  +   
Sbjct: 1923 DTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYE 1982

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL------------- 922
            E      DE  ++T  +T+     +   GK+ +   + +++ L+  +             
Sbjct: 1983 ELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQT 2042

Query: 923  --------------CRPWAEVRWTKDGEEVVESPALLLQ-KEDTVRRLVLPAVQLEDSGE 967
                           +P  E  W K+G ++  S  +     ED V  LV+  V  EDS  
Sbjct: 2043 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSAS 2102

Query: 968  YLCE---IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM-CELSREDAPVRWY 1023
             + +   I  E++S    + +    I + ++   ++A   + +    CE S     V+WY
Sbjct: 2103 IMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWY 2162

Query: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVH 1083
            KDG+EV E +   +  D     L +      D  ++ C   +D    T         +V 
Sbjct: 2163 KDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVE 2222

Query: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHA 1143
                  D+        EL C V+P   + +WY + +E++++    + +    + LT+   
Sbjct: 2223 FVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDV 2282

Query: 1144 QPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP 1203
              ED GEY      +  T  + +   P+  L      S   V  G+ V L  ++S     
Sbjct: 2283 TKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQ---GLSDQKVCEGDIVQLEVKVSLESVE 2339

Query: 1204 VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVA 1263
             VW  +G+ VQ  + + +  +    +L I+      AG Y+    A      LS + +V+
Sbjct: 2340 GVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPAL----GLSTSGRVS 2395

Query: 1264 EPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG-GPVRWYKDGERLASQGRVQLEQAGA 1322
               V V+ P      V    G    L   +S P    V+WY + E++    RVQ    G 
Sbjct: 2396 VYSVDVITP---LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT 2452

Query: 1323 RQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE 1382
            +Q L +    + D G Y     +      +SVE+   +K++  L  LT  E  +  F  E
Sbjct: 2453 KQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK---IKIIRGLRDLTCTETQNVVFEVE 2509

Query: 1383 VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARL 1442
            +S    DV W      + P  + ++  +G    LT+      D G  T  AG   TS +L
Sbjct: 2510 LSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKL 2569

Query: 1443 HVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG 1502
             V    +   + L D    E Q+   E E     + G   W+R G+ LP  + +    DG
Sbjct: 2570 TVAGGAIS--KPLTDQTVAESQEAVFECEVANPDSKG--EWLRDGKHLPLTNNIRSESDG 2625

Query: 1503 HIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE 1562
            H  RL I    L D G Y  +    +T A+L V    +++ + L+++T++E   A F +E
Sbjct: 2626 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEA--VKIKKTLKNLTVTETQDAVFTVE 2683

Query: 1563 LSQEGVTG-EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAAR 1621
            L+   V G +W + GV L    K  I   G  + L +    + D     F    L  +AR
Sbjct: 2684 LTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASAR 2743

Query: 1622 LIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGT 1681
            L V  V   I++ P D+   E  T  FE  +S     V W      + PS + RL +   
Sbjct: 2744 LHVETVK--IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERK 2801

Query: 1682 RRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECT 1741
               L L+   PSDAG Y+  VG       +  +   T+ +   ++++   E   A+FEC 
Sbjct: 2802 VHKLMLQNISPSDAGEYTAVVGQLEC---KAKLFVETLHITKTMKNIEVPETKTASFECE 2858

Query: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALL 1801
            VS       W   G  +    + +I  +GK H L++     ED+ E  F  G  Q  A L
Sbjct: 2859 VSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATL 2918

Query: 1802 EVEALPL-QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860
             V  + +  M +    E+   +      EVTV+  G    WL+ G E+   DK +MR+  
Sbjct: 2919 TVTPIMITSMLKDINAEEKDTI----TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKK 2974

Query: 1861 PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             THSL I +V   D   Y   AG+ ++   L VE
Sbjct: 2975 LTHSLNIRNVHFGDAADYTFVAGKATSTATLYVE 3008



 Score =  283 bits (723), Expect = 1e-75
 Identities = 253/1072 (23%), Positives = 449/1072 (41%), Gaps = 36/1072 (3%)

Query: 831  VDREDAPVRWYKDGQEVEESDFVVLE-NEGPHRRLVLPATQPSDGGEFQC----VAGDEC 885
            V + D    WYK+G ++E SD +     E     LV+      D          +AG+  
Sbjct: 2056 VGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETS 2115

Query: 886  AYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945
            ++  + +            +  VA  +       CE   P+ +V+W KDG EV E     
Sbjct: 2116 SHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYR 2175

Query: 946  LQKEDTVRRLVLPAVQLEDSGEYLCE-IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTL 1004
            +  +  V  L +  +   D+ +Y C  ++DE+   T  +      + + ++   +     
Sbjct: 2176 MHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPES 2235

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
                L C +S E+   +WY + +E++ +    +     R  L +     ED GE+     
Sbjct: 2236 YSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVID 2295

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
                   + +   P  I+   +   D        V+L  +V+    +  W KDG EV+ S
Sbjct: 2296 GKKTTCKLKMKPRPIAILQGLS---DQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPS 2352

Query: 1125 DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            D + +  +  +  L +     EDAG Y        ++ +  ++   V  +   T    + 
Sbjct: 2353 DRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVI---TPLKDVN 2409

Query: 1185 VAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLY 1243
            V  G   VL C++S      V W  N   ++  + ++   +G ++ L I     +  G Y
Sbjct: 2410 VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2469

Query: 1244 TCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWY 1303
                G      +LS         V  +        +  T   ++   V LS  G  V W 
Sbjct: 2470 KLIVGRVETNCNLS---------VEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLV 1363
               + +    + ++E  G    L V      D G+Y   A ++     ++V    + K  
Sbjct: 2521 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISK-- 2578

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQL 1423
              LT  TV E  +A F CEV+ PD+   WLR+G  +     +    +G  R L +   +L
Sbjct: 2579 -PLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKL 2637

Query: 1424 GDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRW 1483
             D G  T +  ++ TSA+L V   ++   + L+++   E QD    VE       G V+W
Sbjct: 2638 DDIGEYTYKVATSKTSAKLKVEAVKIK--KTLKNLTVTETQDAVFTVELTHPNVKG-VQW 2694

Query: 1484 VRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVL 1543
            ++ G  L  + + +++  G I+ L I    + D+  YG         ARL V    ++++
Sbjct: 2695 IKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET--VKII 2752

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            +  +DVT  E  +  F++ +S + V  +W    V++ P  K  + S+   H+L+L  +  
Sbjct: 2753 KKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISP 2812

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
            +D+G  +     L C A+L V  + +T  +   ++EV E  TA+FECE+S       W K
Sbjct: 2813 SDAGEYTAVVGQLECKAKLFVETLHIT--KTMKNIEVPETKTASFECEVSHFNVPSMWLK 2870

Query: 1664 DGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLS 1723
            +G  +  S + ++   G    L +      D+  Y+   G  +   V  T+    + + S
Sbjct: 2871 NGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQ---VSATLTVTPIMITS 2927

Query: 1724 ELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
             L+ ++A E D  TFE TV+    + +W   G  ++   + ++R +   H L +  +   
Sbjct: 2928 MLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFG 2987

Query: 1784 DAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLR 1843
            DA +  F AG A S A L VEA  ++  +H  ++  VL  +RA+ E  VS     V W++
Sbjct: 2988 DAADYTFVAGKATSTATLYVEARHIEFRKHI-KDIKVLEKKRAMFECEVSEPDITVQWMK 3046

Query: 1844 EGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
            +  EL   D+ +++     H L+I   R  D G Y   AG + +  +L VEG
Sbjct: 3047 DDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEG 3098



 Score =  276 bits (707), Expect = 1e-73
 Identities = 401/1774 (22%), Positives = 689/1774 (38%), Gaps = 237/1774 (13%)

Query: 233  PPADPDEAPAPVVEPLKCAPKTF------WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            P   PD+     + P   APK F       V +G  A FR  V+GKP+PE EW+  G  +
Sbjct: 2016 PTFKPDKIE---LSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI 2072

Query: 287  LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRL-RFTR 345
                R   Y   D    L +    A+D    +  A N AG+T S   L V+  +L  FT+
Sbjct: 2073 ERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2132

Query: 346  PLQDVEGREHG-IAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKA 404
             LQDV  +E   +A  EC+     +   W+++   +    KY    +  V  L I  +  
Sbjct: 2133 ELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDT 2192

Query: 405  DDDGIYLCEM--RGRVRTVANVTVKGPILKRLP--RKLDVLEGENAVLLVETLEAGVEGR 460
             D   Y C +     V+T A + V+G +++ +   + ++V E  +  L        +EG+
Sbjct: 2193 SDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGK 2252

Query: 461  WSRDGEEL----PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
            W  +  EL         S  G  + L +  VT+ED GE +F +   +TT  L++K     
Sbjct: 2253 WYHNDVELKSNGKYTITSRRGRQN-LTVKDVTKEDQGEYSFVIDGKKTTCKLKMK----- 2306

Query: 517  PPGPPILAEMFKGHK----NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKA 572
             P P  + +     K    + V L  K    + E   ++  + QEV   D +     +++
Sbjct: 2307 -PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEG--VWMKDGQEVQPSDRVHIVIDKQS 2363

Query: 573  GAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGED 632
              + +        G+Y F I  + G   S  V  +    + P       L+DV V +G  
Sbjct: 2364 HMLLIEDMTKEDAGNYSFTIPAL-GLSTSGRVSVYSVDVITP-------LKDVNVIEGTK 2415

Query: 633  AVFSLDLST--IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQD 690
            AV    +S   +    W+LN E++K ++          R +   KG + RL+++     D
Sbjct: 2416 AVLECKVSVPDVTSVKWYLNDEQIKPDD----------RVQAIVKGTKQRLVINRTHASD 2465

Query: 691  SG---ALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA 747
             G    +VG     V+ +  L++++  + I   +D   LT T ++ VV   ELS      
Sbjct: 2466 EGPYKLIVG----RVETNCNLSVEKIKI-IRGLRD---LTCTETQNVVFEVELSHSGIDV 2517

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF-----ECRTEGVSAFFGVTVQ 802
             W    ++++ S    ++  G+ ++L +      D G++     E  T G     G  + 
Sbjct: 2518 LWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAIS 2577

Query: 803  DPPVH--IVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGP 860
             P     + + +E VF            CEV   D+   W +DG+ +  ++ +  E++G 
Sbjct: 2578 KPLTDQTVAESQEAVF-----------ECEVANPDSKGEWLRDGKHLPLTNNIRSESDGH 2626

Query: 861  HRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKV-----YVAAVRLER 915
             RRL++ AT+  D GE+          + V  +  S+ +   + K+      +     + 
Sbjct: 2627 KRRLIIAATKLDDIGEYT---------YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2677

Query: 916  VVLTCELCRPWAE-VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V T EL  P  + V+W K+G  +  +    +  + T+  L +    + D   Y   +  
Sbjct: 2678 AVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGR 2737

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEA 1034
              AS  + V    V+II    +VT  A+    V     +S +  PV+W+   +E++ S+ 
Sbjct: 2738 LGASARLHV--ETVKIIKKPKDVT--ALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDK 2793

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGD---DSAFF--TVTVTAPPERIVHPAARSL 1089
              L  +    +L+L    P D GE+    G     +  F  T+ +T   + I  P  ++ 
Sbjct: 2794 HRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT- 2852

Query: 1090 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
                         CEV+       W K+G+E+E S+  ++  +G    L + +   ED+ 
Sbjct: 2853 ---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSA 2903

Query: 1150 EY--VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWS 1207
            EY  VC     + T  V     P+   ++      +     + +     ++  G    W 
Sbjct: 2904 EYTFVCGNDQVSATLTV----TPIMITSM---LKDINAEEKDTITFEVTVNYEGISYKWL 2956

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE--- 1264
             NG  ++  +  ++  +     L I+      A  YT  +G A    +L    +  E   
Sbjct: 2957 KNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRK 3016

Query: 1265 --PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
                ++V+  + A                 +S P   V+W KD + L    R+++++   
Sbjct: 3017 HIKDIKVLEKKRAM------------FECEVSEPDITVQWMKDDQELQITDRIKIQKEKY 3064

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
               L +   R  DAG+Y   A      +++F+    E   V++ S    + V E   A  
Sbjct: 3065 VHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV----EGRDVRIRSIKKEVQVIEKQRAVV 3120

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRI--LTLRGCQLGDAGTVTLRAGSTA 1437
              EV+  D D  W ++G  +    Q         RI  + +   +  DAG  T  AG   
Sbjct: 3121 EFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNR 3180

Query: 1438 TSARLHVRETE-LLFLRRLQDVRAEEGQDV-CLEVETGRVGAAGAVRWVRGGQPLPHDSR 1495
            +S  L+V   E    L+ LQ V  + G+      V +GR      + W +  Q L    +
Sbjct: 3181 SSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGR--PQPKISWYKEEQLLSTGFK 3238

Query: 1496 LSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RTLARLSVRPRQL----------- 1540
                 DG  + L +      D   Y CE+ +D     T A LSV   ++           
Sbjct: 3239 CKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP 3298

Query: 1541 -RVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
              ++ PL+D   SEG  A FQ  +S   +   W     ++ P     +      ++L + 
Sbjct: 3299 PAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIA 3358

Query: 1600 GLGLADSGCVSFTADS----LRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQA 1655
                 D G  +F A +    +   A L + E P +I+    + E+ E +   F      A
Sbjct: 3359 EAYPEDEGTYTFVASNAVGQVSSTANLSL-EAPESILHERIEQEI-EMEMKEFSSSFLSA 3416

Query: 1656 LADVTWEKDGNALTPSPRLRLQALG-TRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTV 1714
                  E++G     S  L+L  +  T  LL       S++  Y     + + G   + +
Sbjct: 3417 ------EEEG---LHSAELQLSKINETLELL-------SESPVYPTKFDSEKEGTGPIFI 3460

Query: 1715 RERTVAVLSELRSVSAREGDGATFECTVSEV-ETTGRWELGGRPLRPGARVRIRQEGKKH 1773
            +E + A +S         GD AT   TV  + +   +W   G  L P A  +   +G  H
Sbjct: 3461 KEVSNADIS--------MGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDH 3512

Query: 1774 ILVLSELRAEDAGEVRFQAG------------------------PAQSLALLEVEALPLQ 1809
             L++   + ED GE    A                           +S     +E L   
Sbjct: 3513 SLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGP 3572

Query: 1810 MCRHPPREKTVL---VGRRAVLEVT-VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHS- 1864
               H  +E   +    G  A+ E T V      V W +E  +LC    Y +  H P  S 
Sbjct: 3573 CPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTI-IHNPNGSG 3631

Query: 1865 -LVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
              +++D + ED G Y C+A    G+ +    LLV
Sbjct: 3632 TFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665



 Score =  254 bits (650), Expect = 4e-67
 Identities = 296/1330 (22%), Positives = 527/1330 (39%), Gaps = 109/1330 (8%)

Query: 612  LVPTARLVAGLEDVQ--VYDGEDAVFSLDLST---IIQGTWFLNGEELKSNEPEGQVEPG 666
            LV   +L+   +++Q  V   +D + + +  T    ++  W+ +G E+   +        
Sbjct: 2121 LVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGD-------- 2172

Query: 667  ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD-----SAALTIQESPVHILSPQ 721
              +YR+      H L +  +   D+     +SC  V+D     +A L ++ + V  +   
Sbjct: 2173 --KYRMHSDRKVHFLSILTIDTSDAE---DYSCVLVEDENVKTTAKLIVEGAVVEFVKEL 2227

Query: 722  DRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ 781
              + +  + S    L C +S  +    WY +  +++ +    +     +  L + +   +
Sbjct: 2228 QDIEVPESYSGE--LECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKE 2285

Query: 782  DSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
            D GE+    +G      + ++  P+ I+       V     + V L  +V  E     W 
Sbjct: 2286 DQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKV--CEGDIVQLEVKVSLESVEGVWM 2343

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            KDGQEV+ SD V +  +     L++      D G +          FT+    +S+    
Sbjct: 2344 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYS---------FTIPALGLST---- 2390

Query: 902  PSGKVYVAAVRL------------ERVVLTCELCRP-WAEVRWTKDGEEVVESPALLLQK 948
             SG+V V +V +             + VL C++  P    V+W  + E++     +    
Sbjct: 2391 -SGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV 2449

Query: 949  EDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV 1008
            + T +RLV+      D G Y   +     +  ++V +  ++II    ++T      + VV
Sbjct: 2450 KGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK--IKIIRGLRDLT--CTETQNVV 2505

Query: 1009 LMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA 1068
               ELS     V W     E++ S    +E  G   +L +     +D G++   AG++  
Sbjct: 2506 FEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMT 2565

Query: 1069 FFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQ 1128
               +TV      I  P     D            CEVA   S+  W +DG  +  ++ ++
Sbjct: 2566 SGKLTVAGGA--ISKPLT---DQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIR 2620

Query: 1129 LGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPG 1188
              ++G  R L +   + +D GEY  +     +  +   A+  V+ + ++ T   L V   
Sbjct: 2621 SESDGHKRRLIIAATKLDDIGEYTYK-----VATSKTSAKLKVEAVKIKKTLKNLTVTET 2675

Query: 1189 EPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
            +  V + EL+      V W  NG  ++  E   +  +G    L I+        +Y  + 
Sbjct: 2676 QDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRL 2735

Query: 1248 GAAPGAPSLSF-TVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
            G    +  L   TV++ + P  V A E A               V +S    PV+W+   
Sbjct: 2736 GRLGASARLHVETVKIIKKPKDVTALENATVAFE----------VSVSHDTVPVKWFHKS 2785

Query: 1307 ERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSEL 1366
              +    + +L        L +Q     DAGEY     Q      + VE   + K +  +
Sbjct: 2786 VEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNI 2845

Query: 1367 TPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDA 1426
                V E   A+F CEVS  +    WL+NG  +    + ++   G    L +      D+
Sbjct: 2846 E---VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDS 2902

Query: 1427 GTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRG 1486
               T   G+   SA L V  T ++    L+D+ AEE   +  EV     G +   +W++ 
Sbjct: 2903 AEYTFVCGNDQVSATLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGIS--YKWLKN 2958

Query: 1487 GQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPL 1546
            G  +    +  M      H L I  V   D   Y   +    + A L V  R +   + +
Sbjct: 2959 GVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHI 3018

Query: 1547 EDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADS 1606
            +D+ + E   A F+ E+S+  +T +W +   +L    +  I  + + HRL++    ++D+
Sbjct: 3019 KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3078

Query: 1607 GCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGN 1666
            G  +  A      A+L V    V I     +++V E   A  E E+++   D  W KDG 
Sbjct: 3079 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3138

Query: 1667 ALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
             +    + R + +  RR+  + +     SDAG Y+   G  R+             VL E
Sbjct: 3139 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQE 3198

Query: 1725 LRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
            L+ V+ + G  A F   +S   +    W    + L  G + +   +G+++ L+L E   E
Sbjct: 3199 LQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3258

Query: 1784 DAG----EVRFQAGPAQSLALLEVEALPL-----QMCRHPPREKTVLV------GRRAVL 1828
            DA     E +   G A + A L VE   +     +M  +PP   T L       G+ A  
Sbjct: 3259 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318

Query: 1829 EVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQ 1884
            +  VS +   V W  +  ++ P   + M     T+ L I +  PED+GTY   A    GQ
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3378

Query: 1885 DSTHTRLLVE 1894
             S+   L +E
Sbjct: 3379 VSSTANLSLE 3388



 Score =  212 bits (539), Expect = 3e-54
 Identities = 217/957 (22%), Positives = 410/957 (42%), Gaps = 63/957 (6%)

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
            K   V  G+ A F C +  +  P +EW+ +G+ L P  + ++ R       L +   + +
Sbjct: 5706 KDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDK-VVPRSEGKVHTLTLRDVKLE 5763

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA 372
            D G     A++      +   L VKEP + FT+PL+D    E   AVLEC+V        
Sbjct: 5764 DAGEVQLTAKDFK----THANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 5819

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            WF+    +L  +KYE + +G VR+L+IH    +D   Y C+ +   +T  N+ V  P ++
Sbjct: 5820 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD-FKTSCNLNVVPPHVE 5878

Query: 433  --RLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGV 487
              R    L V E E A    E      + +W +DG E+    +    S G +  LV+   
Sbjct: 5879 FLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKC 5938

Query: 488  TREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPET 547
              +D  E +  +  +RT+ +L V  ++        LA +     +T+ L  +  +P  E 
Sbjct: 5939 LLDDEAEYSCEVRTARTSGMLTV--LEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEV 5996

Query: 548  PFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFH 607
              I+    +E+      +  +  +   + +    +   G+Y  R+ +    G+   V  H
Sbjct: 5997 --IWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK---VKVH 6051

Query: 608  GSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS-TIIQGTWFLNGEELKSNEPEGQVEPG 666
              A     A  ++  +++++ +GE A F   +S       W  + + L+S +        
Sbjct: 6052 ELA-----AEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGD-------- 6098

Query: 667  ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSL 726
              +Y +   G +  L++     QD G  V       + +A LT+ E    ++  +D    
Sbjct: 6099 --KYDVIADGKKRVLVVKDATLQDMGTYV-VMVGAARAAAHLTVIEKLRIVVPLKD---T 6152

Query: 727  TFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF 786
                 + VV  CE++     A W+++ + + +S   ++      + L + +A + D   +
Sbjct: 6153 RVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANY 6212

Query: 787  EC-----RTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
                   R E V +   + V++  + IV+P +   +  +  + V   C+V+R +  ++W 
Sbjct: 6213 NVSLTNHRGENVKSAANLIVEEEDLRIVEPLKD--IETMEKKSVTFWCKVNRLNVTLKWT 6270

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            K+G+EV   + V    +     L +      D GE+   AG + +   + I +  +  V 
Sbjct: 6271 KNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVE 6330

Query: 902  PSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQ 961
                  V     +  V +C+L R  A V+W ++G E+ E      +K+ ++ RL++   +
Sbjct: 6331 HLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCR 6388

Query: 962  LEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVR 1021
            L+D  EY C ++D  +   + V E PV II P  ++  +      VV + EL+++   V+
Sbjct: 6389 LDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDI--LEAPGADVVFLAELNKDKVEVQ 6446

Query: 1022 WYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERI 1081
            W ++ + V + +   +  +G   RL +   +P D GE+   A D  A   + + A P+  
Sbjct: 6447 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELAAAPK-- 6504

Query: 1082 VHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLP 1141
            +  A + L +  G P  + +  +  P  ++  W+K   E E      +       +  + 
Sbjct: 6505 IKTADQDLVVDVGKPLTMVVPYDAYPK-AEAEWFK---ENEPLSTKTIDTTAEQTSFRIL 6560

Query: 1142 HAQPEDAGEY--VCETRHEA----ITFNVILAEPPVQFLAL-ETTPSPLCVAPGEPV 1191
             A+  D G Y  V + +H      I   VI    PV+ L + ET    + +A  EP+
Sbjct: 6561 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPL 6617



 Score =  202 bits (514), Expect = 3e-51
 Identities = 155/558 (27%), Positives = 257/558 (46%), Gaps = 27/558 (4%)

Query: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNG 1411
            S+E P   K+   +   TV +G DA FR  V   PD +  W +NG  +    ++      
Sbjct: 2028 SMEAP---KIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPE 2084

Query: 1412 SSRI-LTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELL-FLRRLQDVRAEEGQD 1465
             +   L +R     D+ ++ ++A    G T++ A L V+  +L+ F + LQDV A+E   
Sbjct: 2085 DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDT 2144

Query: 1466 VC-LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC-- 1522
            +   E ET        V+W + G  +    +  M  D  +H L I  +  +D   Y C  
Sbjct: 2145 MATFECETSEPFVK--VKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVL 2202

Query: 1523 -ESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
             E  + +T A+L V    +  ++ L+D+ + E  S   +  +S E + G+W    V+L  
Sbjct: 2203 VEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKS 2262

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
              K  I S   R  L +  +   D G  SF  D  +   +L ++  P+ I++G  D +V 
Sbjct: 2263 NGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVC 2322

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC- 1700
            EGD    E ++S    +  W KDG  + PS R+ +       +L +      DAG YS  
Sbjct: 2323 EGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFT 2382

Query: 1701 --AVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRP 1757
              A+G + +G V +     +V V++ L+ V+  EG  A  EC VS  + T  +W L    
Sbjct: 2383 IPALGLSTSGRVSV----YSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQ 2438

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            ++P  RV+   +G K  LV++   A D G  +   G  ++   L VE + +       R+
Sbjct: 2439 IKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIKI---IRGLRD 2495

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
             T    +  V EV +S SG  V W  +  E+ P  KY++ +HG  + L + ++  +D+G 
Sbjct: 2496 LTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGK 2555

Query: 1878 YCCQAGQDSTHTRLLVEG 1895
            Y   AG++ T  +L V G
Sbjct: 2556 YTFYAGENMTSGKLTVAG 2573



 Score =  189 bits (480), Expect = 2e-47
 Identities = 271/1226 (22%), Positives = 469/1226 (38%), Gaps = 182/1226 (14%)

Query: 15   LRFPRPVRVVSGAEAE--LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
            L+F  P++ V+  E E  +  V L      V W K  Q+L  +  +S   +G  H +   
Sbjct: 5432 LKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFK 5491

Query: 73   AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                 D       A   + EA     +TVLE                      G P F  
Sbjct: 5492 DLSIDDTSQIRVEAMGMSSEA----KLTVLE----------------------GDPYFTG 5525

Query: 133  GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
              +    +   EV+L C       P + W KDG    E+  S +  ++     DG    L
Sbjct: 5526 KLQDYTGVEKDEVILQCEISKADAP-VKWFKDGK---EIKPSKNAVIKA----DGKKRML 5577

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             L+   A   D G Y C                      S   D ++    +V PL    
Sbjct: 5578 ILK--KALKSDIGQYTCDCGT---------------DKTSGKLDIEDREIKLVRPLHSVE 5620

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
                V E + A+F   +    E +I  +W+ +               G  +L+   C+ K
Sbjct: 5621 ----VMETETARFETEIS---EDDIHANWKLK---------------GEALLQTPDCEIK 5658

Query: 313  DRG------LYVCAARNSAG------QTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVL 360
            + G      L+ C    + G         S+  L VK   +   RPL+DV       A  
Sbjct: 5659 EEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATF 5718

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420
            +C++    IP  W+ + ++L P  K     EG V  L +  +K +D G      +   +T
Sbjct: 5719 DCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKD-FKT 5777

Query: 421  VANVTVKGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SS 475
             AN+ VK P ++      D  V EG  AVL  E      + +W ++G E+    +    +
Sbjct: 5778 HANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVA 5837

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
             G +  LV+   T ED    T    + +T+  L V      PP    L  +         
Sbjct: 5838 DGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV-----VPPHVEFLRPLTD------- 5885

Query: 536  LTWKPPEPAPETPFIYRLERQEVGSEDWIQC-----FSIEKAGAVE--VPGDC-VPSEGD 587
            L  +  E A     + R   +    +D  +      + I   GAV   V   C +  E +
Sbjct: 5886 LQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAE 5945

Query: 588  YRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGT 646
            Y   + T    G            L   A     L +++V + +      ++S    +  
Sbjct: 5946 YSCEVRTARTSGM--------LTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVI 5997

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSC--PGVQD 704
            W+   EE+        +E G  RY I  +G +  L++     +D+G    ++C  P  + 
Sbjct: 5998 WYKGDEEI--------IETG--RYEILTEGRKRILVIQNAHLEDAG---NYNCRLPSSRT 6044

Query: 705  SAALTIQESPVHILS-PQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLV 763
               + + E     +S PQ   +L     E+    C +S+  FP  W +D + +E  +   
Sbjct: 6045 DGKVKVHELAAEFISKPQ---NLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGDKYD 6101

Query: 764  VKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSE 823
            V  DG+K  L++ +A +QD G +        A   +TV +  + IV P +   V     +
Sbjct: 6102 VIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTRVK--EQQ 6158

Query: 824  CVMLACEVDREDAPVRWYKDGQEV-EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAG 882
             V+  CEV+ E A  +W+++ + + + S +++L+ +  +   +  A              
Sbjct: 6159 EVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHL------------ 6206

Query: 883  DECAYFTVTITDVSSWIVYPSGKVYV--------------AAVRLERVVLTCELCRPWAE 928
            D+ A + V++T+     V  +  + V                +  + V   C++ R    
Sbjct: 6207 DDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVT 6266

Query: 929  VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPV 988
            ++WTK+GEEV     +  + +     L +      D GEY+     + +   + + E P 
Sbjct: 6267 LKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPT 6326

Query: 989  RIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVL 1048
              +   ++ T+     +  V  C+LSRE A V+WY++G E++E +    E+DG   RL++
Sbjct: 6327 EFVEHLEDQTV--TEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLII 6384

Query: 1049 PAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR-VELRCEVAP 1107
               + +D  E+ C   D  +   + V   P  I+ P    L+    APG  V    E+  
Sbjct: 6385 KDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILE----APGADVVFLAELNK 6440

Query: 1108 AGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILA 1167
               +V+W ++ + V   D  Q+ +EG    L +   +P D GEY    + +     + LA
Sbjct: 6441 DKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELA 6500

Query: 1168 EPPVQFLALETTPSPLCVAPGEPVVL 1193
              P     ++T    L V  G+P+ +
Sbjct: 6501 AAP----KIKTADQDLVVDVGKPLTM 6522



 Score =  188 bits (478), Expect = 4e-47
 Identities = 324/1488 (21%), Positives = 548/1488 (36%), Gaps = 185/1488 (12%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERL--SFPADGAEHGLLLTAALPTDAG 80
            V  G++A  +  V+G+P P   W K G ++  S+R+   +P D     L++      D+ 
Sbjct: 2043 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCE-LVIRDVTAEDSA 2101

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
              + +A N AGE  + A + V                           +  T      V 
Sbjct: 2102 SIMVKAINIAGETSSHAFLLVQAKQL----------------------ITFTQELQDVVA 2139

Query: 141  RGAEVVLT--CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            +  + + T  C     P   + W KDGM   EV +   + +   R          L IL 
Sbjct: 2140 KEKDTMATFECETSE-PFVKVKWYKDGM---EVHEGDKYRMHSDRKVH------FLSILT 2189

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN 258
                D+  Y C             L++      +     + A    V+ L    +   V 
Sbjct: 2190 IDTSDAEDYSC------------VLVEDENVKTTAKLIVEGAVVEFVKEL----QDIEVP 2233

Query: 259  EGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
            E    +  C V   PE  IE  W    + L    +     R G   L V     +D+G Y
Sbjct: 2234 ESYSGELECIV--SPE-NIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEY 2290

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
                        +  +L +K   +   + L D +  E  I  LE KV    +   W ++ 
Sbjct: 2291 SFVIDGKK----TTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDG 2346

Query: 378  QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL-------CEMRGRVRTVANVTVKGPI 430
            Q + P  +   + +     L+I  +  +D G Y            GRV +V +V V  P+
Sbjct: 2347 QEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRV-SVYSVDVITPL 2405

Query: 431  LKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPV---ICQSSSGHMHALVLPG 486
                 + ++V+EG  AVL  +     V   +W  + E++     +     G    LV+  
Sbjct: 2406 -----KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 2460

Query: 487  VTREDAGEVTFSLGNSRTTTLLRVKCVK--------HSPPGPPILAEMFKGHKN-TVLLT 537
                D G     +G   T   L V+ +K               ++ E+   H    VL  
Sbjct: 2461 THASDEGPYKLIVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520

Query: 538  WKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
            +K  E  P +   Y++E              I K   + +  D    EG Y F       
Sbjct: 2521 FKDKEIKPSSK--YKIEAHG----------KIYKLTVLNMMKD---DEGKYTF---YAGE 2562

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLST-IIQGTWFLNGEELKS 656
            +  S  +   G A   P       L D  V + ++AVF  +++    +G W  +G+ L  
Sbjct: 2563 NMTSGKLTVAGGAISKP-------LTDQTVAESQEAVFECEVANPDSKGEWLRDGKHL-- 2613

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVH 716
                    P     R E  G + RLI+ A K  D G    +     + SA L ++   + 
Sbjct: 2614 --------PLTNNIRSESDGHKRRLIIAATKLDDIGEYT-YKVATSKTSAKLKVEAVKI- 2663

Query: 717  ILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLIL 775
                +   +LT T ++  V T EL+  +     W K+G  +E +E   + + G  + L +
Sbjct: 2664 ---KKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI 2720

Query: 776  PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
                + D   +  R   + A   + V+   + I  P++   V A+ +  V     V  + 
Sbjct: 2721 KNCAIVDESVYGFRLGRLGASARLHVETVKI-IKKPKD---VTALENATVAFEVSVSHDT 2776

Query: 836  APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-ECA----YFTV 890
             PV+W+    E++ SD   L +E    +L+L    PSD GE+  V G  EC       T+
Sbjct: 2777 VPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL 2836

Query: 891  TITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKED 950
             IT     I  P  K              CE+        W K+G E+  S    +  + 
Sbjct: 2837 HITKTMKNIEVPETKT---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQG 2887

Query: 951  TVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM 1010
             + +L++     EDS EY     ++  S T+TVT  P+ I     ++   A   + +   
Sbjct: 2888 KLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVT--PIMITSMLKDIN--AEEKDTITFE 2943

Query: 1011 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 1070
              ++ E    +W K+G+E++ ++   +        L +      D  ++   AG  ++  
Sbjct: 2944 VTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTA 3003

Query: 1071 TVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
            T+ V A   R +       D+      R    CEV+     V+W KD  E++ +D +++ 
Sbjct: 3004 TLYVEA---RHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQ 3060

Query: 1131 AEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEP 1190
             E     L +P  +  DAG+Y         T  + +    V+  +++     + V   + 
Sbjct: 3061 KEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIK---KEVQVIEKQR 3117

Query: 1191 VVLSCELSRAGAPVVWSHNGRPV--QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
             V+  E++       W  +G  +  Q  E  +   E     + I     + AG YT  +G
Sbjct: 3118 AVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAG 3177

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGE 1307
                  S++  V   EPP   V  E     V+S  G        +SG P   + WYK+ +
Sbjct: 3178 R--NRSSVTLYVNAPEPP--QVLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKEEQ 3231

Query: 1308 RLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL----VSVEEPLLVK-- 1361
             L++  + +    G    L +  A   DA  Y C+A  D  +      +SVE P +V   
Sbjct: 3232 LLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPD 3291

Query: 1362 ---------LVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGS 1412
                     +++ L      EG  A F+C VS  D  V+W      + P     M Q   
Sbjct: 3292 QEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFED 3351

Query: 1413 SRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLFLRRLQ 1456
            +  L +      D GT T  A    G  +++A L +   E +   R++
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIE 3399



 Score =  125 bits (315), Expect = 3e-28
 Identities = 228/1150 (19%), Positives = 415/1150 (36%), Gaps = 176/1150 (15%)

Query: 43   VVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVL 102
            V+W    +++  S +    A G  + L +   +  D G Y       AGE   +  +TV 
Sbjct: 2517 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTF----YAGENMTSGKLTVA 2572

Query: 103  EPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWE 162
                S P                     LT    Q V    E V  C     P+    W 
Sbjct: 2573 GGAISKP---------------------LT---DQTVAESQEAVFECEVAN-PDSKGEWL 2607

Query: 163  KDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGA 222
            +DG          H  L      +  G    L I A +L D G Y          ++  A
Sbjct: 2608 RDG---------KHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVAT----SKTSA 2654

Query: 223  LLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWE 282
             L+V                     +K   K   V E + A F   +       ++W   
Sbjct: 2655 KLKVE-----------------AVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKN 2697

Query: 283  GRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLR 342
            G  +L    +     +   + L++  C   D  +Y        G+  ++ +LHV+   ++
Sbjct: 2698 G-VVLESNEKYAISVKGTIYSLRIKNCAIVDESVY----GFRLGRLGASARLHVE--TVK 2750

Query: 343  FTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRL 402
              +  +DV   E+     E  V +  +P  WF +   + P  K+  + E  V +L++  +
Sbjct: 2751 IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNI 2810

Query: 403  KADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWS 462
               D G Y   + G++   A + V+   + +  + ++V E + A    E     V   W 
Sbjct: 2811 SPSDAGEYTAVV-GQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSMWL 2869

Query: 463  RDGEELPVICQSS---SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
            ++G E+ +  +      G +H L++   + ED+ E TF  GN + +  L V  +  +   
Sbjct: 2870 KNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSML 2929

Query: 520  PPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPG 579
              I AE     K+T+  T++         + +     E+ S D  Q  + +   ++ +  
Sbjct: 2930 KDINAE----EKDTI--TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRN 2983

Query: 580  DCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDL 639
                   DY F    V+G   S   ++  + H+         ++D++V + + A+F  ++
Sbjct: 2984 VHFGDAADYTF----VAGKATSTATLYVEARHI----EFRKHIKDIKVLEKKRAMFECEV 3035

Query: 640  S-TIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFS 698
            S   I   W  + +EL+  +          R +I+++   HRL++ + +  D+G      
Sbjct: 3036 SEPDITVQWMKDDQELQITD----------RIKIQKEKYVHRLLIPSTRMSDAGKYT-VV 3084

Query: 699  CPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDG----Q 754
              G   +A L ++   V I S +  V +     +R V+  E++  D  A WYKDG     
Sbjct: 3085 AGGNVSTAKLFVEGRDVRIRSIKKEVQV--IEKQRAVVEFEVNEDDVDAHWYKDGIEINF 3142

Query: 755  KVEESELLVVKMDGRKHRLILPEAKVQDSGE--FECRTEGVSAFFGVTVQDPPVHIVDPR 812
            +V+E    VV  + R HR+ + E +  D+GE  F       S    V   +PP  ++   
Sbjct: 3143 QVQERHKYVV--ERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPP-QVLQEL 3199

Query: 813  EHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPS 872
            + V V +        A    R    + WYK+ Q +         ++G    L+L    P 
Sbjct: 3200 QPVTVQS-GKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3258

Query: 873  DGGEFQCVAGDE------CAYFTVTITDVSS----WIVYPSGKVY----VAAVRLERVVL 918
            D   + C A ++       A  +V + +V S      VYP   +           +    
Sbjct: 3259 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318

Query: 919  TCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS 978
             C +     +V W    +++  S    + + +   +L +     ED G Y     +    
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3378

Query: 979  FTVTVT---EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEE---- 1031
             + T     E P  I++ R       +  E  + M E S         ++GL   E    
Sbjct: 3379 VSSTANLSLEAPESILHER-------IEQEIEMEMKEFSSSFLSAE--EEGLHSAELQLS 3429

Query: 1032 --SEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGD------DSAFFTVTVTAPPERIVH 1083
              +E L L  + P       + +   G  F+ +  +      D A  +VTV   P+    
Sbjct: 3430 KINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPK---- 3485

Query: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHA 1143
                                       +++W+ +G+ +  S   +   +G   +L +   
Sbjct: 3486 --------------------------PKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFT 3519

Query: 1144 QPEDAGEYVC 1153
            + ED GEY C
Sbjct: 3520 KLEDEGEYTC 3529



 Score =  116 bits (290), Expect = 2e-25
 Identities = 219/1074 (20%), Positives = 389/1074 (36%), Gaps = 173/1074 (16%)

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+ DGQ++  + +  VV++ +G    +++PAT PSD GE+  VA +     ++++     
Sbjct: 1444 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPAT-PSDSGEWTVVAQNRAGRSSISVILTVE 1502

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             + +    ++V  ++   +    E  R   +VR T +    +    + L+  D +     
Sbjct: 1503 AVEHQVKPMFVEKLKNVNIK---EGSRLEMKVRATGNPNPDI----VWLKNSDIIVPHKY 1555

Query: 958  PAVQLEDS-GEYLCEID----DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
            P +++E + GE   +ID     +SA +T T      R      + T   V +E       
Sbjct: 1556 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGR------DTTRCKVNVEV------ 1603

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCR-LVLPAAQP---------EDGGEFVCD 1062
                        +  E E    L++ R   R + +  P  +P          + G+    
Sbjct: 1604 ------------EFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDK 1651

Query: 1063 AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGL 1119
                  FF   +T+   +   PA      HF         C + P G     V W  DG 
Sbjct: 1652 EKQQKPFFKKKLTSLRLKRFGPA------HF--------ECRLTPIGDPTMVVEWLHDGK 1697

Query: 1120 EVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETT 1179
             +EA++ L++  E    +L    A   D+G   C   ++  T               + T
Sbjct: 1698 PLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGT---------------DHT 1742

Query: 1180 PSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAH 1239
             + L V   + +V   +L            GR     +GL+   E  R          AH
Sbjct: 1743 SATLIVKDEKSLVEESQLP----------EGR-----KGLQRIEELERM---------AH 1778

Query: 1240 AGLYTCQSGAAPGAPSLSFTVQVAEP-PVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGG 1298
             G  T   G             V  P PVRV+  E A+ R R T             P  
Sbjct: 1779 EGALT---GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVT-----------GYPQP 1824

Query: 1299 PVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPL 1358
             V WY +G+ +    R ++   G    L +   +S D GE             V+ E P 
Sbjct: 1825 KVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGE-----------VKVTAENP- 1871

Query: 1359 LVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL 1418
               ++     L + + +D       +P               P P+  + + G  +    
Sbjct: 1872 -EGVIEHKVKLEIQQREDFRSVLRRAP--------------EPRPEFHVHEPGKLQF--- 1913

Query: 1419 RGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAA 1478
                  +   V     +T T   + ++  E +   ++ +   E         E G   A 
Sbjct: 1914 ------EVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 1967

Query: 1479 GAVRWVRGGQPLPHDSRLSMAQDGHIH----RLFIHGVILADQGTYGCESHHDRTLARLS 1534
             AV      +   ++  L   +D  +H            LA++G     +     +  LS
Sbjct: 1968 TAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKI-ELS 2026

Query: 1535 VRPRQLRVLRPLEDVTISEGGSATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIH-SDGH 1592
                  ++   ++  T+ +G  A F++  + +     EW + GV++    + + +  + +
Sbjct: 2027 PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDN 2086

Query: 1593 RHRLVLNGLGLADSG-----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT-A 1646
               LV+  +   DS       ++   ++   A  L+  +  +T  +   D+   E DT A
Sbjct: 2087 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMA 2146

Query: 1647 TFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR 1706
            TFECE S+    V W KDG  +    + R+ +      L +     SDA  YSC +    
Sbjct: 2147 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE 2206

Query: 1707 --AGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARV 1764
                  +L V    V  + EL+ +   E      EC VS     G+W      L+   + 
Sbjct: 2207 NVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKY 2266

Query: 1765 RIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGR 1824
             I     +  L + ++  ED GE  F     ++   L+++  P+ + +    +K V  G 
Sbjct: 2267 TITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQK-VCEGD 2325

Query: 1825 RAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               LEV VS       W+++G E+ P D+  +     +H L+I D+  ED G Y
Sbjct: 2326 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNY 2379



 Score =  100 bits (249), Expect = 1e-20
 Identities = 121/498 (24%), Positives = 198/498 (39%), Gaps = 82/498 (16%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F+  P+ + ++ G +AE  C +  E  PV  W++  + L + ++    ADG +  L++  
Sbjct: 6057 FISKPQNLEILEGEKAEFVCSISKESFPVQ-WKRDDKTLESGDKYDVIADGKKRVLVVKD 6115

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEP-----PASDPELQPAERPLPSPGSGEGAP 128
            A   D G YV       G A AAA +TV+E      P  D  ++  +             
Sbjct: 6116 ATLQDMGTYVV----MVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQ------------- 6158

Query: 129  VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                           EVV  C          ++  +    + ++DSS + +         
Sbjct: 6159 ---------------EVVFNCEVNTEGAKAKWFRNE----EAIFDSSKYIILQ------K 6193

Query: 189  GASLALRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
                 LRI  A L D   Y     N  G + ++ A L V           +E    +VEP
Sbjct: 6194 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIV-----------EEEDLRIVEP 6242

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
            L    K     E K   F C V  +    ++W   G   +P   R+ YR      +L + 
Sbjct: 6243 L----KDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE-VPFDNRVSYRVDKYKHMLTIK 6296

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNS 367
             C   D G Y+     +AGQ  S  +L + E    F   L+D    E   AV  C++   
Sbjct: 6297 DCGFPDEGEYIV----TAGQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSRE 6352

Query: 368  RIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK 427
            +    W+R  + +   +KY+  ++G++ RLII   + DD+  Y C +  R ++ A + V+
Sbjct: 6353 KANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDR-KSRARLFVE 6411

Query: 428  GPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQS------SSGHM 479
               ++ +    D+LE  G + V L E  +  VE +W R+     V+ Q       S G +
Sbjct: 6412 EIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNN---MVVVQGDKHQMMSEGKI 6468

Query: 480  HALVLPGVTREDAGEVTF 497
            H L +  +   D GE  F
Sbjct: 6469 HRLQICDIKPRDQGEYRF 6486



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 104/483 (21%), Positives = 194/483 (40%), Gaps = 77/483 (15%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F +  + ++V+    A  +C V  EP   V W K  Q+L  ++R+    +   H LL+ +
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPS 3072

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
               +DAG Y       AG   + A + V                       EG  V +  
Sbjct: 3073 TRMSDAGKYTV----VAGGNVSTAKLFV-----------------------EGRDVRIRS 3105

Query: 134  PRSQ-WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
             + +  V+     V+        +   +W KDG+ ++      H  +   R         
Sbjct: 3106 IKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYVVERRIH------- 3157

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             + I   R  D+G Y   A    G  ++   L V+ P           P  V++ L+  P
Sbjct: 3158 RMFISETRQSDAGEYTFVA----GRNRSSVTLYVNAP----------EPPQVLQELQ--P 3201

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
             T  V  GK A+F   + G+P+P+I W+ E   LL    +  +      + L ++    +
Sbjct: 3202 VT--VQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3258

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRL------------RFTRPLQDVEGREHGIAVL 360
            D  +Y C A+N  G   ++  L V+ P +                PLQD    E   A  
Sbjct: 3259 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY---LCEMRGR 417
            +C+V  + +  +W+ +D+++ P R +   +     +L I     +D+G Y        G+
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3378

Query: 418  VRTVANVTVKGP---ILKRLPRKLDVLEGENAVLLVETLEAGV---EGRWSRDGEELPVI 471
            V + AN++++ P   + +R+ +++++   E +   +   E G+   E + S+  E L ++
Sbjct: 3379 VSSTANLSLEAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELL 3438

Query: 472  CQS 474
             +S
Sbjct: 3439 SES 3441



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 20/219 (9%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  L+  +PV V SG  A    V+ G P P + W K  Q L+   +  F  DG E+ LL
Sbjct: 3192 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3251

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            L  A P DA VY C A+N  G A  +A+++V  P    P+ +    P          P  
Sbjct: 3252 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP----------PAI 3301

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +T  +      G      CR  G      ++ KD     ++  S  F +   + ED    
Sbjct: 3302 ITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKD----KKIKPSRFFRMT--QFED---- 3351

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQP 229
            +  L I  A   D G Y   A NA G   + A L +  P
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAP 3390



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 191/1020 (18%), Positives = 346/1020 (33%), Gaps = 168/1020 (16%)

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVT 891
             A V+WY +G E++ES  +   N      L +      D G ++ V     G+   Y T+ 
Sbjct: 25906 AEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLD 25965

Query: 892   ITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDT 951
             +T    +  Y S +      R     LT      +A   + K  E    S    ++ + T
Sbjct: 25966 VTG-GDYTTYASQRRDEEVPRSVFPELT--RTEAYAVSSFKKTSEMEASSSVREVKSQMT 26022

Query: 952   VRRLVLPAVQLEDSGEYLC------EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLE 1005
               R  L + +   S E          ++++S +  +  T     +  PR   ++     E
Sbjct: 26023 ETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR---SMTVYEGE 26079

Query: 1006  CVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--- 1061
                  C+   E  P V W + G  +  S    +     +    + + Q  D G +     
Sbjct: 26080 SARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVE 26139

Query: 1062  -DAGDDSAFFTVT----------VTAPPE------RIVHPAA------------------ 1086
                G   A FT+T          VT+PP       R+  P A                  
Sbjct: 26140 NSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAV 26199

Query: 1087  -----------RSLDLHFGAPGRV-------------ELRCEVAPA---GSQVRWYKDGL 1119
                        +   L   AP ++             +L C V  +     +V WYKDG 
Sbjct: 26200 SPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGK 26259

Query: 1120  EVEASDALQL--GAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLAL- 1176
             +++ +   Q    A+G T  L + +    D GEYVCE   E  T    L      F ++ 
Sbjct: 26260 KLKENGHFQFHYSADG-TYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH 26318

Query: 1177  -----------------ETT---------PSPLCVAP-----------GEPVVLSCELSR 1199
                              E+T         P P+   P               V    +  
Sbjct: 26319 EKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKA 26378

Query: 1200  AGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSL 1256
              G P    +W+ +G+ + +G   +L  +     L I     + +GLYTC    + G+ S 
Sbjct: 26379 TGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSS 26438

Query: 1257  SFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQ 1316
             S  + +           + Q     TP     +   +S         K  E   SQ ++ 
Sbjct: 26439 SCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEA-KSQEKLA 26497

Query: 1317  LEQAGARQVLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGD 1375
             L++  ++ ++  +  +S     E      + ++    S E     ++ +  T ++++EG 
Sbjct: 26498 LKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQ 26557

Query: 1376  DATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGS 1435
                 +  ++    DV W+ NG  +T   +     +GS + LT++     D G +T     
Sbjct: 26558 RLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTC---I 26613

Query: 1436  TATSARLHVRETELLFLRRLQDVRA----------EEGQDVCLEVETGRVGAAGAVRWVR 1485
             + T   +   + +L   + L D  A           EGQ+V    E      +  + W +
Sbjct: 26614 SKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISG-EPSPEIEWFK 26672

Query: 1486  GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDR----TLARLSVRPRQLR 1541
                P+   S +S+++  +++ L I    ++D G Y  ++ + R      A L V P    
Sbjct: 26673 NNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP---L 26729

Query: 1542  VLRPLEDVTISEGGSATFQLELSQEGV--TGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
             V  P  +V +   G  + Q   S + V  +          +        ++     +   
Sbjct: 26730 VEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQ 26789

Query: 1600  GLGLADSGCVSFTADSLRCAARLI-------------VREVPVTIVRGPHDLEVTEGDTA 1646
              +       V  ++ S    + +              +R +P  I   P D+ + EG   
Sbjct: 26790 SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVL 26849

Query: 1647  TFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVG 1703
             T  C  + +   +VTW   G  +    + R     T  L  L +      D G Y+ ++G
Sbjct: 26850 TVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLG 26909



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 113/494 (22%), Positives = 184/494 (37%), Gaps = 82/494 (16%)

Query: 15   LRFPRPVRVVSGAEAELKCVV--LGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
            L+F  P+   +  E E    V  L      VVW K   +L  S  +   ++G  H L + 
Sbjct: 5077 LKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMK 5136

Query: 73   AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
                 D    + + +    E  + A + VLE                        P F  
Sbjct: 5137 EVTLDD----ISQIKAQVKELSSTAQLKVLEAD----------------------PYFTV 5170

Query: 133  GPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
                +  +   E+ L C      +  + W KDG   +E+  S  ++++        G   
Sbjct: 5171 KLHDKTAVEKDEITLKCEVS--KDVPVKWFKDG---EEIVPSPKYSIK------ADGLRR 5219

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQA---GALLQVHQPPESPPADPDEAPAPVVEPLK 249
             L+I  A L D G YVC        A       L++V            E P   VE   
Sbjct: 5220 ILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKV------------EKPLYGVE--- 5264

Query: 250  CAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL--PDRRRLMYRDRDGGFVLKVL 307
                  +V E  H +     + +P+   +W  +G+PL   PD   +     DG   + +L
Sbjct: 5265 -----VFVGETAHFEIE---LSEPDVHGQWKLKGQPLTASPDCEII----EDGKKHILIL 5312

Query: 308  Y-CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            + CQ    G     A N+     SA  L VKE  L F  PL DV+  E   A  EC+V  
Sbjct: 5313 HNCQLGMTGEVSFQAANAK----SAANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSR 5368

Query: 367  SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
                  W +  Q +    ++E I++GT   ++I     +D+  Y+ E   +  T   + +
Sbjct: 5369 EPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDK-HTSGKLII 5427

Query: 427  KGPILKRLPRKLDVL--EGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHA 481
            +G  LK L    DV   E E+AV  VE     +  +W ++ + L     +     G  H+
Sbjct: 5428 EGIRLKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHS 5487

Query: 482  LVLPGVTREDAGEV 495
            +    ++ +D  ++
Sbjct: 5488 ITFKDLSIDDTSQI 5501



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 63/239 (26%), Positives = 93/239 (38%), Gaps = 32/239 (13%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            +PP  +   + V V+ G    L+C + G P P V W +   Q+ +S             L
Sbjct: 895  TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARL 954

Query: 70   LLTAALPTDAGVYVCRARNAAG-------------EAYAAAAVTVLEPPASDPELQPAER 116
            ++  A   D+G + C A N AG             E +      V E   ++ +     R
Sbjct: 955  MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014

Query: 117  PL---------PSPGSGE-GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGM 166
             +            G GE  AP F+T P  Q ++ G  VV  C+ GG P+P +YW+K G+
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074

Query: 167  ALDEVWD-SSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL 224
             L   +     +  Q G  +        L I      D+G Y    RN HG   A A L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECK--------LVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 92/387 (23%), Positives = 137/387 (35%), Gaps = 78/387 (20%)

Query: 18    PRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPT 77
             PR + V  G  A   C   GEP P V W + GQ L+ S R        +    +++   +
Sbjct: 26070 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQAS 26129

Query: 78    DAGVYVCRARNAAGEAYAAAAVTVL------------------EPPASDPELQPAERPLP 119
             D G Y     N+ G+  A   +T+                   EP    PE   + + + 
Sbjct: 26130 DEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 26189

Query: 120   SPGSG------------------EGAPVFLTGPRSQWVLRGAE---VVLTC--RAGGLPE 156
             SP                     +  PV      +Q++   A      LTC   +  L  
Sbjct: 26190 SPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRA 26249

Query: 157   PTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHG 216
               + W KDG  L E   + HF      + DG   +  L+I      D G YVC      G
Sbjct: 26250 KEVTWYKDGKKLKE---NGHFQFH--YSADG---TYELKINNLTESDQGEYVCEISGEGG 26301

Query: 217   HAQAG------ALLQVHQP--------------PESPPADPDEAPAPVVEPLKCAP---- 252
              ++        A   +H+                ES      E  AP  EP+   P    
Sbjct: 26302 TSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAP--EPISSKPVIVT 26359

Query: 253   --KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
               +   V+    AKF     G+P P   W  +G+ +    +  +  D+ GGF L++    
Sbjct: 26360 GLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDK-GGFFLEIHKTD 26418

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHVK 337
               D GLY C  +NSAG   S+ +L +K
Sbjct: 26419 TSDSGLYTCTVKNSAGSVSSSCKLTIK 26445



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 78/398 (19%)

Query: 22   RVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGLLLTAALPTDA 79
            R++ G      C + G P P + W K G+++   ER  + F  DG    L +   LP D 
Sbjct: 1255 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVLPEDE 1313

Query: 80   GVYVCRARNAAGEAYAAAAVTV-----LEPPASDPELQPAER------------PL---- 118
            G+Y   A N  G A  +  + V     L  P   P L+P  R            P+    
Sbjct: 1314 GIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSP 1373

Query: 119  -----------------PSPG-----SGEG------APVFLTGPRSQWVLRGAEVVLTCR 150
                              SPG     + E        PVF+  P S   L G       +
Sbjct: 1374 ARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLK 1433

Query: 151  AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCH 210
              G P P  +W  DG  +  V D +H  +     EDG   + +L I+ A   DSG +   
Sbjct: 1434 VVGRPMPETFWFHDGQQI--VNDYTHKVV---IKEDG---TQSLIIVPATPSDSGEWTVV 1485

Query: 211  ARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVM 270
            A+N  G +    +L V        A   +     VE L    K   + EG   + +    
Sbjct: 1486 AQNRAGRSSISVILTVE-------AVEHQVKPMFVEKL----KNVNIKEGSRLEMKVRAT 1534

Query: 271  GKPEPEIEWHWEGRPLLPDR-RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTL 329
            G P P+I W      ++P +  ++      G   LK+    ++D   Y   A N AG+  
Sbjct: 1535 GNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDT 1594

Query: 330  SAVQLHVK------EPRLRFTRPLQDVEGREHGIAVLE 361
            +  +++V+      EP  +   P      +E     LE
Sbjct: 1595 TRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELE 1632



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 89/379 (23%), Positives = 134/379 (35%), Gaps = 64/379 (16%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  +   +      G  A  +C V G    V  W    +++  S           + L 
Sbjct: 3298 PPAIITPLQDTVTSEGQPARFQCRVSGTDLKVS-WYSKDKKIKPSRFFRMTQFEDTYQLE 3356

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP------------------------A 106
            +  A P D G Y   A NA G+  + A +++  P                         A
Sbjct: 3357 IAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKEFSSSFLSA 3416

Query: 107  SDPELQPAERPLP--------------------SPGSGEGAPVFLTGPRSQWVLRGAEVV 146
             +  L  AE  L                     S   G G P+F+    +  +  G    
Sbjct: 3417 EEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTG-PIFIKEVSNADISMGDVAT 3475

Query: 147  LTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGV 206
            L+    G+P+P + W  +G+ L    D            DG   SL   IL  +L D G 
Sbjct: 3476 LSVTVIGIPKPKIQWFFNGVLLTPSADYKFVF-------DGDDHSLI--ILFTKLEDEGE 3526

Query: 207  YVCHARNAHGHAQAGALLQVHQPPES-PPADPDEAPAPVVEPL--KCAP------KTFWV 257
            Y C A N +G     A L+++   E     + + A A  +E L   C P      K    
Sbjct: 3527 YTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRC 3586

Query: 258  NEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
             +G  A F   V+G+P P + W  E + L       +  + +G     V   Q +D GLY
Sbjct: 3587 AQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVNDPQREDSGLY 3646

Query: 318  VCAARNSAGQTLSAVQLHV 336
            +C A N  G++  A +L V
Sbjct: 3647 ICKAENMLGESTCAAELLV 3665



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 123/502 (24%), Positives = 190/502 (37%), Gaps = 74/502 (14%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
            G+ A  +C+V      +  W K G  +  S +  F ADG +  L +     +DAG Y C 
Sbjct: 4636 GSSAIFECLV-SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 4694

Query: 86   ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145
             R    E  + A + V E P                          T      V++G  +
Sbjct: 4695 LRLGNKEKTSTAKLVVEELPVR---------------------FVKTLEEEVTVVKGQPL 4733

Query: 146  VLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP-GASLALRILAARLPDS 204
             L+C      E  + W KDG  + E         +PGR   G  G   AL I  A   D+
Sbjct: 4734 YLSCELN--KERDVVWRKDGKIVVE---------KPGRIVPGVIGLMRALTINDADDTDA 4782

Query: 205  GVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAK 264
            G Y     NA+ + +  + ++V +               +V+P+    +   V     A 
Sbjct: 4783 GTYTVTVENAN-NLECSSCVKVVEVIRD----------WLVKPI----RDQHVKPKGTAI 4827

Query: 265  FRCYVMGKPEPEIEWH--WEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
            F C +  K  P I+W   ++  P  P+ +  + RD      LK+     +D   Y   A 
Sbjct: 4828 FACDI-AKDTPNIKWFKGYDEIPAEPNDKTEILRD-GNHLYLKIKNAMPEDIAEY---AV 4882

Query: 323  NSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLP 382
               G+   A +L + E  +   +P++DV   E   A  + ++  + IP  W  + + L P
Sbjct: 4883 EIEGKRYPA-KLTLGEREVELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRP 4941

Query: 383  CRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLE 442
                E   EG  R L +H++K D  G  L +    + T A +TVK   L       DV  
Sbjct: 4942 SPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAI-TTAILTVKEIELDFAVPLKDVTV 5000

Query: 443  GENAVLLVE---TLEAGVEGRWSRDGEELPVICQSS-------SGHMHALVLPGVTREDA 492
             E      E   T EA V   WS+     P I +SS        G  H LV+     +D 
Sbjct: 5001 PERRQARFECVLTREANV--IWSKG----PDIIKSSDKFDIIADGKKHILVINDSQFDDE 5054

Query: 493  GEVTFSLGNSRTTTLLRVKCVK 514
            G  T  +   +T+  L V  ++
Sbjct: 5055 GVYTAEVEGKKTSARLFVTGIR 5076



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 57/227 (25%), Positives = 87/227 (38%), Gaps = 10/227 (4%)

Query: 2    KASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFP 61
            K  S  +G+ P F++      +  G  A L   V+G P P + W   G  L  S    F 
Sbjct: 3447 KFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFV 3506

Query: 62   ADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPA--SDPELQPAERPLP 119
             DG +H L++      D G Y C A N  G+   +A + +        D E + A     
Sbjct: 3507 FDGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSL 3566

Query: 120  SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                G   P FL   +     +G   +      G P PT+ W K+     ++  S ++ +
Sbjct: 3567 EKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKEN---KQLCTSVYYTI 3623

Query: 180  QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
                    P  S    +   +  DSG+Y+C A N  G +   A L V
Sbjct: 3624 -----IHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 118/552 (21%), Positives = 194/552 (35%), Gaps = 105/552 (19%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGL 69
            P F+  P   ++V G      C V G P P V W+K G  L    R  +S+     E  L
Sbjct: 1036 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1095

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL---------PS 120
            +++     DAG Y    RN  GE   +A+ ++LE    +  ++  +  L           
Sbjct: 1096 VISMTFADDAGEYTIVVRNKHGET--SASASLLEEADYELLMKSQQEMLYQTQVTAFVQE 1153

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
            P  GE AP F+     +   +   ++    A        Y E      D+ +  S F   
Sbjct: 1154 PKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE------DQEFHISSF--- 1204

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240
                E+     +  RI+   L +                    L      E    D  E+
Sbjct: 1205 ----EERLIKEIEYRIIKTTLEE--------------------LLEEDGEEKMAVDISES 1240

Query: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
             A V        K + + EG    F C + G P P+I W+ +G+ +    R  M   +DG
Sbjct: 1241 EA-VESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1299

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK--------------EPRLRFTRP 346
               L++     +D G+Y   A N  G  + + +L+V+              EP  R  R 
Sbjct: 1300 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRI-RS 1358

Query: 347  LQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADD 406
            L         I +   ++  +R+  A      R+ P R+ E+ +E  + RL         
Sbjct: 1359 LSPRSVSRSPIRMSPARMSPARMSPARM-SPARMSPGRRLEETDESQLERLY-------- 1409

Query: 407  DGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGV-EGRWSRDG 465
                                  P+    P     LEG+ A   ++ +   + E  W  DG
Sbjct: 1410 ---------------------KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDG 1448

Query: 466  EEL-----PVICQSSSGHMHALVLPGVTREDAGEVTF----SLGNSRTTTLLRVKCVKHS 516
            +++       +     G    +++P  T  D+GE T       G S  + +L V+ V+H 
Sbjct: 1449 QQIVNDYTHKVVIKEDGTQSLIIVP-ATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQ 1507

Query: 517  PPGPPILAEMFK 528
                P+  E  K
Sbjct: 1508 V--KPMFVEKLK 1517



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 91/395 (23%), Positives = 142/395 (35%), Gaps = 87/395 (22%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA--EHGL 69
            P F+   + V +  G+  E+K    G P P +VW K    +   +      +G   E  L
Sbjct: 1510 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1569

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP-------- 121
             + + +  D+  Y   A N AG       V V E   ++PE    ER L  P        
Sbjct: 1570 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNV-EVEFAEPE---PERKLIIPRGTYRAKE 1625

Query: 122  -GSGEGAPVFLTGPRSQW------------------------VLRGAEVVLTCRAGGLPE 156
              + E  P+ L   + QW                        + R       CR   + +
Sbjct: 1626 IAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGD 1685

Query: 157  PTLY--WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
            PT+   W  DG  L+        A +     +    SL   +  +R  DSG+  C A N 
Sbjct: 1686 PTMVVEWLHDGKPLEA-------ANRLRMINEFGYCSLDYGVAYSR--DSGIITCRATNK 1736

Query: 215  HGHAQAGA---------LLQVHQPPESPPA---------------------DPDEAPAPV 244
            +G     A         L++  Q PE                         D  E   P 
Sbjct: 1737 YGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKP- 1795

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFV 303
               +   P+   V EG+ A+FRC V G P+P++ W+  G+ +   +R R+ Y   DG   
Sbjct: 1796 --DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHY 1850

Query: 304  LKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
            L ++ C++ D G     A N  G     V+L +++
Sbjct: 1851 LDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1885



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 113/549 (20%), Positives = 201/549 (36%), Gaps = 46/549 (8%)

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT---------V 981
             WTKDG+ + +     L ++     L +      DSG Y C + + + S +         +
Sbjct: 26388 WTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAI 26447

Query: 982   TVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDG 1041
               TE          E+T      +  V+  E+S++       K   E +  E L L+ + 
Sbjct: 26448 KDTEAQKVSTQKTSEIT----PQKKAVVQEEISQKALRSEEIKMS-EAKSQEKLALKEEA 26502

Query: 1042  PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAAR--SLDLHFGAPGRV 1099
              +   VL + + +       +        T T  A  E   H   +  S  +      R+
Sbjct: 26503 SK---VLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 26559

Query: 1100  ELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR-HE 1158
              L+  +A A + V+W  +G+E+  S+  + G  G  +TLT+  A   D G   C ++  E
Sbjct: 26560 VLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKE 26618

Query: 1159  AIT---FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQ 1214
              I    +++ L++      A  + P    +  G+ V+ +CE+S   +P + W  N  P+ 
Sbjct: 26619 GIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS 26678

Query: 1215  EGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS----GAAPGAPSLSFTVQVAEPPVRVV 1270
                 + +        L I+ A  + +G YT ++    G      SL     V EP   VV
Sbjct: 26679 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 26738

Query: 1271  APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQ------GRVQLEQAGARQ 1324
                +  T   S  G      V +S       +       AS         +  +   + Q
Sbjct: 26739 LRTSGDT---SLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQ 26795

Query: 1325  VLRVQGARSGDAG-EYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE- 1382
                V+ + S   G   +      +   L +    +  K+ +  + +++ EG   T  C  
Sbjct: 26796 ESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAF 26855

Query: 1383  VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL--RGCQLGDAGTVTL----RAGST 1436
                P  +VTW   G  +    Q       +  + TL     Q  D G  TL      GS 
Sbjct: 26856 TGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSD 26915

Query: 1437  ATSARLHVR 1445
             + +  +H+R
Sbjct: 26916 SATVNIHIR 26924



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 60/208 (28%), Positives = 78/208 (37%), Gaps = 29/208 (13%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASE---RLSFPADGAEHGLLLTAALPTDAGVY 82
             G        +   P P V W K GQ++   +   + +F +D   + L + +    D   Y
Sbjct: 25207 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 25266

Query: 83    VCRARNAAGEAYAAAAVTV-LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLR 141
                ARN  GE    A +TV L PP +D  L+P  + L            L     Q    
Sbjct: 25267 TVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRL------------LANAECQ---E 25311

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS-LALRILAAR 200
             G  V    R  G+P PTL WEKDG  L         +L P       G    AL I    
Sbjct: 25312 GQSVCFEIRVSGIPPPTLKWEKDGQPL---------SLGPNIEIIHEGLDYYALHIRDTL 25362

Query: 201   LPDSGVYVCHARNAHGHAQAGALLQVHQ 228
               D+G Y   A N  G     A LQV +
Sbjct: 25363 PEDTGYYRVTATNTAGSTSCQAHLQVER 25390



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 57/217 (26%), Positives = 83/217 (38%), Gaps = 30/217 (13%)

Query: 17    FPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALP 76
             F   + +  G    LK  + G     V W   G +L  SE   +   G++  L +  A  
Sbjct: 26547 FSTQMSINEGQRLVLKANIAGATD--VKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASH 26604

Query: 77    TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRS 136
              D G+  C ++   G       +T L    SD                  AP F++ PRS
Sbjct: 26605 RDEGILTCISKTKEGIVKCQYDLT-LSKELSD------------------APAFISQPRS 26645

Query: 137   QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRI 196
             Q +  G  V+ TC   G P P + W K+ + +     SS+ ++   R         +L I
Sbjct: 26646 QNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS---ISSNVSISRSR------NVYSLEI 26696

Query: 197   LAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               A + DSG Y   A+N  G   A A L V    E P
Sbjct: 26697 RNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEP 26733



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 81/369 (21%), Positives = 132/369 (35%), Gaps = 67/369 (18%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLA--ASERLSFPADGAEHGL 69
            P F+  P   + + G  A     V+G P P   W   GQQ+    + ++    DG +  L
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-SL 1469

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
            ++  A P+D+G +   A+N AG +  +  +TV          +  E  +         P+
Sbjct: 1470 IIVPATPSDSGEWTVVAQNRAGRSSISVILTV----------EAVEHQV--------KPM 1511

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
            F+   ++  +  G+ + +  RA G P P + W K+    D +    +    P    +G  
Sbjct: 1512 FVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS---DIIVPHKY----PKIRIEGTK 1564

Query: 190  ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPAD-----------PD 238
               AL+I +    DS  Y   A N  G       + V      P  +             
Sbjct: 1565 GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAK 1624

Query: 239  EAPAPVVEPLKCAPKTFWVNEG---------------------------KHAKFRCYVMG 271
            E  AP +EPL          EG                            H + R   +G
Sbjct: 1625 EIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIG 1684

Query: 272  KPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
             P   +EW  +G+P L    RL   +  G   L      ++D G+  C A N  G   ++
Sbjct: 1685 DPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTS 1743

Query: 332  VQLHVKEPR 340
              L VK+ +
Sbjct: 1744 ATLIVKDEK 1752



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 193/1091 (17%), Positives = 363/1091 (33%), Gaps = 146/1091 (13%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G++ +F   V  KP  E++W+  G   L +  ++ Y +  G   L++L C   D G Y  
Sbjct: 25891 GQNTRFILNVQSKPTAEVKWYHNGVE-LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRA 25949

Query: 320   AARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECK---VPNSRIPTAWFRE 376
                N  G+      L              DV G ++     + +   VP S  P     E
Sbjct: 25950 VCTNYKGEASDYATL--------------DVTGGDYTTYASQRRDEEVPRSVFPELTRTE 25995

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGI--YLCEMRGRVRTVA------------ 422
                +   +K  ++E  +  R +  ++    + +  Y       +++ A            
Sbjct: 25996 AYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTT 26055

Query: 423   ---NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ---SS 475
                  T+   IL + PR + V EGE+A    +T    V    W R G+ L    +   ++
Sbjct: 26056 RKIKTTLAARILTK-PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTT 26114

Query: 476   SGHMHALVLPGVTREDAGEVTFSLGNSR-------TTTLLRVKCVKHSPPGPPIL----- 523
             + +     +  V   D G  +  + NS        T T+ + +  + +   PP +     
Sbjct: 26115 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 26174

Query: 524   ----AEMFKGHKNTVLLTWKPPEPA----------PETPFIYRLERQEVGSEDWIQCFSI 569
                  E  K  K       K PEP+            TP   +++   V +   I  F  
Sbjct: 26175 RVKSPEAVKSPKRV-----KSPEPSHPKAVSPTETKPTP-TEKVQHLPVSAPPKITQFLK 26228

Query: 570   EKAGAVEVPGDCVPSEGDYRFRICTVSGHGR----SPHVVFHGSAHLVPTARLVAGLEDV 625
              +A        CV      R +  T    G+    + H  FH SA               
Sbjct: 26229 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSA--------------- 26273

Query: 626   QVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI--L 683
                   D  + L ++ + +      GE +     EG      L++  +     H  +  +
Sbjct: 26274 ------DGTYELKINNLTESD---QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 26324

Query: 684   HAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV 743
                K  D            +  A   I   PV +   QD    + + ++  V      R 
Sbjct: 26325 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 26384

Query: 744   DFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
                A W KDG+ + +     +  D     L + +    DSG + C  +  +     + + 
Sbjct: 26385 --TAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 26442

Query: 804   PPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQ----EVEESDFVVLENEG 859
                 I D          TSE       V +E+   +  +  +    E +  + + L+ E 
Sbjct: 26443 TIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEA 26502

Query: 860   PHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLT 919
                 +     + +     + +  +E    +    +V +     +    ++    +R+VL 
Sbjct: 26503 SKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLK 26562

Query: 920   CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESA-- 977
               +     +V+W  +G E+  S         + + L +      D G   C    +    
Sbjct: 26563 ANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIV 26621

Query: 978   ------SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVE 1030
                   + +  +++ P  I  PR +        + V+  CE+S E +P + W+K+ L + 
Sbjct: 26622 KCQYDLTLSKELSDAPAFISQPRSQNINEG---QNVLFTCEISGEPSPEIEWFKNNLPIS 26678

Query: 1031  ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLD 1090
              S  + + R      L +  A   D G++   A +     + T +     +V   +R + 
Sbjct: 26679 ISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVV 26738

Query: 1091  LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE 1150
             L     G   L+   +    Q+   K      +  +    +    +  ++         E
Sbjct: 26739 LR--TSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQE 26796

Query: 1151  YVCE------------TRHEAITFNVILAE----PPVQFLALETTPSPLCVAPGEPVVLS 1194
                E            T+ E+ T  ++ A     PP     +E  PS + +  G+ + ++
Sbjct: 26797 SFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPP----KIEALPSDISIDEGKVLTVA 26852

Query: 1195  CELSRAGAP-VVWSHNGRPVQEGEGLELHAEG--PRRVLCIQAAGPAHAGLYTCQSGAAP 1251
             C  +    P V WS  GR +   E    H E       L I        GLYT   G   
Sbjct: 26853 CAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEF 26912

Query: 1252  GAPSLSFTVQV 1262
             G+ S +  + +
Sbjct: 26913 GSDSATVNIHI 26923



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 60/241 (24%), Positives = 80/241 (33%), Gaps = 46/241 (19%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P  ++G ++  V+ G  V L C   G P PT+ W ++   ++   D      Q G A   
Sbjct: 897  PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIAR-- 953

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE---------------- 231
                  L I  A   DSG + C A N  G       L V    E                
Sbjct: 954  ------LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1007

Query: 232  -----------------SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                                A P E  AP         K     EG    F C V G P+
Sbjct: 1008 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV---EGGSVVFGCQVGGNPK 1064

Query: 275  PEIEWHWEGRPLLPD-RRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQ 333
            P + W   G PL    R ++ Y  + G   L +    A D G Y    RN  G+T ++  
Sbjct: 1065 PHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASAS 1124

Query: 334  L 334
            L
Sbjct: 1125 L 1125



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 69/279 (24%), Positives = 113/279 (40%), Gaps = 54/279 (19%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE----RLSFPADGAEH 67
           P F +  + V V+ G+ A  +  + G P P V W + GQ ++ S     ++SF    A+ 
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK- 64

Query: 68  GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            L + A    ++G Y  +A N +G+A + A + V    A                     
Sbjct: 65  -LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA--------------------P 103

Query: 128 PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
           P F+   +S  V +G++V L  R  G+P P + + +DG    E+  S  F +        
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGA---EIQSSLDFQISQ------ 154

Query: 188 PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
            G   +L I  A   DSG Y  +A N+ G A + A L V    E P            + 
Sbjct: 155 EGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVP-----------AKK 203

Query: 248 LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            K    T  ++E +  +         E +IE H++ R +
Sbjct: 204 TKTIVSTAQISESRQTRI--------EKKIEAHFDARSI 234



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 63/225 (28%), Positives = 91/225 (40%), Gaps = 30/225 (13%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD---GAEHG 68
             P F    R + V   + A L C V G P P+V W + G+++ A + L +      G  H 
Sbjct: 24431 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIA-DGLKYRIQEFKGGYHQ 24489

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
             L++ +    DA VY  RA N  G     A++ V           PA+  LP    G GA 
Sbjct: 24490 LIIASVTDDDATVYQVRATNQGGSVSGTASLEV---------EVPAKIHLPKTLEGMGA- 24539

Query: 129   VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
                        LRG  V +     G P+P + W+K    +D   ++ H+ +   R+    
Sbjct: 24540 --------VHALRGEVVSIKIPFSGKPDPVITWQKGQDLID---NNGHYQVIVTRS---- 24584

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
               SL       R  D+G YV  A+N  G  Q    L V   P+ P
Sbjct: 24585 FTSLVFPNGVER-KDAGFYVVCAKNRFGIDQKTVELDVADVPDPP 24628



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG-L 69
            PP FL+  +P+R   G  A  +  V+GEP P V W K  +QL  S   +   +    G  
Sbjct: 3574 PPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTF 3633

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVL 102
            ++      D+G+Y+C+A N  GE+  AA + VL
Sbjct: 3634 IVNDPQREDSGLYICKAENMLGESTCAAELLVL 3666



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 120/558 (21%), Positives = 202/558 (36%), Gaps = 73/558 (13%)

Query: 492   AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
             A E    +G     ++    C    PPGPP   ++    +++V L W  P      P   
Sbjct: 18480 AAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKG 18539

Query: 551   YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSA 610
             Y +E +E  +++W  C         +     +    +Y FRIC ++  G        GS 
Sbjct: 18540 YVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSV 18599

Query: 611   HLV-----PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEP 665
                     P   L A L  V V     A  +L L   I+G       E+K  + EG +  
Sbjct: 18600 VAQERIEPPEIELDADLRKVVVLR---ASATLRLFVTIKGR---PEPEVKWEKAEGILTD 18653

Query: 666   GALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVS 725
                R +IE       L++  V   DSG    ++     +S + T   +   + SP   V+
Sbjct: 18654 ---RAQIEVTSSFTMLVIDNVTRFDSGR---YNLTLENNSGSKTAFVNVRVLDSPSAPVN 18707

Query: 726   LTF--TTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAKVQD 782
             LT      + V L+ E   +D        G K+  +  +V K +  RK    +     + 
Sbjct: 18708 LTIREVKKDSVTLSWEPPLID-------GGAKI--TNYIVEKRETTRKAYATITNNCTKT 18758

Query: 783   SGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDREDAP 837
             +   E   EG S +F V   +      P    +P + V    +    V L  +V R  A 
Sbjct: 18759 TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVK-VSEPPLPPGRVTLV-DVTRNTAT 18816

Query: 838   VRWYK---DGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
             ++W K   DG        V ++ +G  +       +  +       AG+E  +    + +
Sbjct: 18817 IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNE 18876

Query: 895   -------------------VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
                                +   +  P     V A    ++ +  +  RP A V W KDG
Sbjct: 18877 KGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFK-GRPQATVNWRKDG 18935

Query: 936   EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT---------EP 986
             + + E+  + +    TV  L +     ED G Y   + + + S TV +T           
Sbjct: 18936 QTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPG 18995

Query: 987   PVRIIYPRDEVTLIAVTL 1004
             P+RI    DEV+  ++T+
Sbjct: 18996 PIRI----DEVSCDSITI 19009



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 75/318 (23%), Positives = 117/318 (36%), Gaps = 24/318 (7%)

Query: 43    VVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV- 101
             V W  G +QL  SE+     +     L +      D G Y C+  N  GE  + A + V 
Sbjct: 25103 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 25162

Query: 102   ----LEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEP 157
                 +        ++  +R   +    E  P F     ++    G  V         PEP
Sbjct: 25163 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 25222

Query: 158   TLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGH 217
              + W K G  +    +   +  +  +          L I +    D   Y   ARN +G 
Sbjct: 25223 HVTWYKSGQKIKPGDNDKKYTFESDKG------LYQLTINSVTTDDDAEYTVVARNKYGE 25276

Query: 218   AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
                 A L V   P  PP D    P       K         EG+   F   V G P P +
Sbjct: 25277 DSCKAKLTVTLHP--PPTDSTLRPM-----FKRLLANAECQEGQSVCFEIRVSGIPPPTL 25329

Query: 278   EWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             +W  +G+PL L     +++   D  + L +     +D G Y   A N+AG T  + Q H+
Sbjct: 25330 KWEKDGQPLSLGPNIEIIHEGLD-YYALHIRDTLPEDTGYYRVTATNTAGST--SCQAHL 25386

Query: 337   KEPRLRFTRPLQDVEGRE 354
             +  RLR+ +  Q+ + +E
Sbjct: 25387 QVERLRYKK--QEFKSKE 25402



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 144/696 (20%), Positives = 245/696 (35%), Gaps = 128/696 (18%)

Query: 252   PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
             P++  V EG+ A+F C   G+P P + W  +G+ L    R  +   +      ++   QA
Sbjct: 26070 PRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKS-TFEISSVQA 26128

Query: 312   KDRGLYVCAARNSAGQTLSAVQLHVKEPRL---------RFTRPLQDVEGREHGIAVLEC 362
              D G Y     NS G+  +   L +++ R+         R   P   V+  E   +    
Sbjct: 26129 SDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRV 26188

Query: 363   KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
             K P    P A    + +  P  K + +      + I   LKA+             + +A
Sbjct: 26189 KSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPK-ITQFLKAEAS-----------KEIA 26236

Query: 423   NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHM--- 479
              +T                  E++VL  +      E  W +DG++L       +GH    
Sbjct: 26237 KLT---------------CVVESSVLRAK------EVTWYKDGKKL-----KENGHFQFH 26270

Query: 480   ------HALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKG 529
                   + L +  +T  D GE    +    G S+T      +  K        ++E  K 
Sbjct: 26271 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKS 26330

Query: 530   HKNTVLLTW------KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE------V 577
              + T   T       K PEP    P I    +    S D +  F+++  G          
Sbjct: 26331 DQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK 26390

Query: 578   PGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSL 637
              G  +   G Y+                F    H   T+   +GL    V +   +V S 
Sbjct: 26391 DGKAITQGGKYKL---------SEDKGGFFLEIHKTDTSD--SGLYTCTVKNSAGSVSSS 26439

Query: 638   DLSTI--IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH---------AV 686
                TI  I+ T        K++E   Q +   ++  I QK L+   I           A+
Sbjct: 26440 CKLTIKAIKDTEAQKVSTQKTSEITPQ-KKAVVQEEISQKALRSEEIKMSEAKSQEKLAL 26498

Query: 687   KHQDSGALVGFSCPGVQDSAALTIQESPVH-------ILSPQDR---------VSLTFTT 730
             K + S  L+      V+ SAA ++++S VH         S + R           ++   
Sbjct: 26499 KEEASKVLIS---EEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINE 26555

Query: 731   SERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC-- 788
              +R+VL   ++       W  +G ++  SE     + G    L + +A  +D G   C  
Sbjct: 26556 GQRLVLKANIAGAT-DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCIS 26614

Query: 789   -RTEG-VSAFFGVT----VQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWY 841
                EG V   + +T    + D P  I  PR     +    + V+  CE+  E +P + W+
Sbjct: 26615 KTKEGIVKCQYDLTLSKELSDAPAFISQPRSQ---NINEGQNVLFTCEISGEPSPEIEWF 26671

Query: 842   KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEF 877
             K+   +  S  V +        L +     SD G++
Sbjct: 26672 KNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 26707



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/115 (27%), Positives = 50/115 (43%)

Query: 9     GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
             G  P   +  + V    G  A+L C ++G P P + W + G++L  S +    +DG  H 
Sbjct: 24033 GEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT 24092

Query: 69    LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGS 123
             L +      D GVY C A N  GE   ++ + +   P   P     E+   + GS
Sbjct: 24093 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGS 24147



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 81/379 (21%), Positives = 133/379 (35%), Gaps = 82/379 (21%)

Query: 131   LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD--------------------- 169
             LT PRS  V  G     +C   G P PT+ W + G  L                      
Sbjct: 26067 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 26126

Query: 170   EVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGV-YVCHARNAHGHAQAGALLQVHQ 228
             +  D  ++++    +E    A   L I  AR+ +  V      ++     ++   ++  +
Sbjct: 26127 QASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPK 26186

Query: 229   PPESP-PADP------DEAPAPVVE----PLKCAPK--TFWVNEGKH--AKFRCYVMGK- 272
               +SP P+ P      +  P P  +    P+   PK   F   E     AK  C V    
Sbjct: 26187 RVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSV 26246

Query: 273   -PEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
                 E+ W+ +G+ L  +     +   DG + LK+      D+G YVC      G + + 
Sbjct: 26247 LRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTN 26306

Query: 332   VQ--------LHVKEPRL----------------RFTRP---------------LQDVEG 352
             +Q        +H K  ++                R T P               LQD   
Sbjct: 26307 LQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTV 26366

Query: 353   REHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL 411
                 +A    K      PTA W ++ + +    KY+  E+     L IH+    D G+Y 
Sbjct: 26367 SSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYT 26426

Query: 412   CEMR---GRVRTVANVTVK 427
             C ++   G V +   +T+K
Sbjct: 26427 CTVKNSAGSVSSSCKLTIK 26445



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 44/164 (26%), Positives = 77/164 (46%), Gaps = 10/164 (6%)

Query: 1366 LTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPG--PQVEMAQNGSSRILTLRGCQ 1422
            L  + V EG  ATF   +S  P  +V+W R+G V++    P V+++ +     LT+    
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVT 71

Query: 1423 LGDAGTVTLRA----GSTATSARLHVRETELL--FLRRLQDVRAEEGQDVCLEVETGRVG 1476
              ++G  +L+A    G   ++A L V+       F++RLQ +   +G  V L+V    + 
Sbjct: 72   KANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIP 131

Query: 1477 AAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
                V++ R G  +       ++Q+G ++ L I      D GTY
Sbjct: 132  TP-VVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTY 174



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 12/141 (8%)

Query: 1020 VRWYKDGLEVEESE--ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV--- 1074
            V W++DG  +  S    + +     R +L +PA    + G +   A + S   T T    
Sbjct: 37   VSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELL 96

Query: 1075 ----TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
                TAPP  +     +S+ +  G+  R+++R    P    V++Y+DG E+++S   Q+ 
Sbjct: 97   VKAETAPPNFVQR--LQSMTVRQGSQVRLQVRVTGIPT-PVVKFYRDGAEIQSSLDFQIS 153

Query: 1131 AEGPTRTLTLPHAQPEDAGEY 1151
             EG   +L +  A PED+G Y
Sbjct: 154  QEGDLYSLLIAEAYPEDSGTY 174



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 71/338 (21%), Positives = 130/338 (38%), Gaps = 44/338 (13%)

Query: 189   GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
             G+   L I  A   D G+  C ++   G  +    L + +       +  +APA + +P 
Sbjct: 26592 GSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSK-------ELSDAPAFISQP- 26643

Query: 249   KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
                 ++  +NEG++  F C + G+P PEIEW     P+       + R R+  + L++  
Sbjct: 26644 ----RSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRN-VYSLEIRN 26698

Query: 309   CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
                 D G Y   A+N  GQ  +   L V         P ++V  R  G   L+    +  
Sbjct: 26699 ASVSDSGKYTIKAKNFRGQCSATASLMVLP---LVEEPSREVVLRTSGDTSLQGSFSSQS 26755

Query: 369   IPTAWFREDQRL----------LPCRKYEQIEE---GTVRRLIIHRLKADDDGI-YLCEM 414
             +  +  +++             +   K+  +      +++   +    +   GI  + ++
Sbjct: 26756 VQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQL 26815

Query: 415   RGRVRTVANVTVKG--PILKRLPRKLDVLEGE-NAVLLVETLEAGVEGRWSRDGEELPVI 471
                   +    ++G  P ++ LP  + + EG+   V    T E   E  WS  G +   I
Sbjct: 26816 ESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRK---I 26872

Query: 472   CQSSSGHMH--------ALVLPGVTREDAGEVTFSLGN 501
                  G  H         L++  V ++D G  T SLGN
Sbjct: 26873 HSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 26910



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 97/418 (23%), Positives = 155/418 (37%), Gaps = 52/418 (12%)

Query: 373  WFREDQRLLPCRKYEQIEEGTVR-RLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
            W R + R +   K++ +EEG V  +  + R++A    +    +        NV  K P  
Sbjct: 7834 WMRVNSRPIKDLKFK-VEEGVVPDKEYVLRVRA----VNAIGVSEPSEISENVVAKDPDC 7888

Query: 432  KRL----PRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHA---LV 483
            K         + V+EGE   + V      V    W +DG+E+    + +  + H    L 
Sbjct: 7889 KPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLE 7948

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP 543
            +P   R DAG  T +L N   +    +       PGP    +     K++  LTW+PPE 
Sbjct: 7949 VPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEF 8008

Query: 544  APETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
               TP + Y LER+E G   +I   S E   +  V  D +P+ G+Y FR+  V+  G   
Sbjct: 8009 DGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVK-DLIPN-GEYFFRVKAVNKVGGGE 8066

Query: 603  HVVFHGSAHLV----------------PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG- 645
            ++                         PTA  +       +YDG   +    +  I +G 
Sbjct: 8067 YIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGE 8126

Query: 646  -TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD 704
              W    E L             L Y    KGL+           ++ A +         
Sbjct: 8127 ERWKRCNEHLVP----------ILTY--TAKGLEEGKEYQFRVRAENAAGISEPSRATPP 8174

Query: 705  SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESEL 761
            + A+   ++P  IL    R SL     + + L   +S   +P  TW KD   +   E+
Sbjct: 8175 TKAVDPIDAPKVIL----RTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEI 8228



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 24/209 (11%)

Query: 413   EMRGRVRTVANVTVKGP-------ILKRLPRKLDVLEGENAVLLVET-----LEAGVEGR 460
             + R   RT  N++           + + +P ++D+     ++L V+      L+A V G+
Sbjct: 12766 QFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGK 12825

Query: 461   ------WSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 511
                   W +DG  L     I  +   ++  L L  V R+D+G+ T +  NS  +    +K
Sbjct: 12826 PMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIK 12885

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPP-EPAPETPFIYRLERQEVGSEDWIQCFSIE 570
                   PGPP   ++ K + +  +L+W+PP E        Y ++++E    +W Q  +  
Sbjct: 12886 LKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATV 12945

Query: 571   KAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                +  V  + +    +Y+FRIC  + +G
Sbjct: 12946 PITSCSV--EKLIEGHEYQFRICAENKYG 12972



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 100/471 (21%), Positives = 191/471 (40%), Gaps = 59/471 (12%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G+ A+  C ++G+P P+I+W+  G+ L+  R+  M  D      L V+  + +D G+Y C
Sbjct: 24050 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSD-GRTHTLTVMTEEQEDEGVYTC 24108

Query: 320   AARNSAGQTLSAVQLHVK-EPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFRED 377
              A N  G+  ++ +L ++  P+     PL++   G       L        +P   +   
Sbjct: 24109 IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHG 24168

Query: 378   QRLLPCRKYEQIEE-----GTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKG-PIL 431
             Q+LL   +   IE        V + +  +  A    + L  + G V  + +V ++  P  
Sbjct: 24169 QKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDK 24228

Query: 432   KRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVT--- 488
                P  ++ L   +AV+  +   A   G W  +   +   C++  G    LV   ++   
Sbjct: 24229 PTGPIVIEALLKNSAVISWKP-PADDGGSWITN--YVVEKCEAKEGAEWQLVSSAISVTT 24285

Query: 489   ------REDAG-------EVTFSLGNS---RTTTLLRVKCVKHSPPGPPILAEMFKGHKN 532
                    E+AG       + TF + +     +  +++    K   PG P +  +    K+
Sbjct: 24286 CRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAV---TKD 24342

Query: 533   TVLLTWKPPEPAPETPF-IYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DYRF 590
             + ++ WKPP          Y LE++E     WI   + E    V    + +  EG +Y F
Sbjct: 24343 SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLI--EGLEYEF 24400

Query: 591   RICTVSGHGRS-----PHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLS----T 641
             R+   +  G S        +   S   +        L ++ V    +A     ++     
Sbjct: 24401 RVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKP 24460

Query: 642   IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQ-KGLQHRLILHAVKHQDS 691
             I++  W+  G+E+ ++          L+YRI++ KG  H+LI+ +V   D+
Sbjct: 24461 IVK--WYRQGKEIIAD---------GLKYRIQEFKGGYHQLIIASVTDDDA 24500



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 54/214 (25%), Positives = 86/214 (40%), Gaps = 27/214 (12%)

Query: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD-EVWDSSHFALQPGRAE 185
           AP F    +S  VL G+         G P P + W +DG  +          +   GRA+
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64

Query: 186 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
                   L I A    +SG Y   A N  G A + A L V           + AP   V
Sbjct: 65  --------LTIPAVTKANSGRYSLKATNGSGQATSTAELLV---------KAETAPPNFV 107

Query: 246 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 305
           + L    ++  V +G   + +  V G P P ++++ +G  +   +  L ++    G +  
Sbjct: 108 QRL----QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI---QSSLDFQISQEGDLYS 160

Query: 306 VLYCQA--KDRGLYVCAARNSAGQTLSAVQLHVK 337
           +L  +A  +D G Y   A NS G+  S  +L V+
Sbjct: 161 LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 81/338 (23%), Positives = 134/338 (39%), Gaps = 47/338 (13%)

Query: 700  PGVQDSAALTIQESPVHILSPQDRVSLTF--TTSERVVLTCELSRVDFPA-TWYKDGQKV 756
            P +Q  A  ++QE        Q    +T     S+ ++ T E+S  +  +   Y D   V
Sbjct: 4130 PRIQQGAKTSLQEEMDSFSGSQKVEPITEPEVESKYLISTEEVSYFNVQSRVKYLDATPV 4189

Query: 757  EESELLVVKMDGRKHRLILP----EAKVQDSGEFECRTEGVSAFFGVTVQD--PPVH--I 808
             +     V  D ++   + P    E    +SG  E  T  +    G  +++  P +H  +
Sbjct: 4190 TKGVASAVVSDEKQDESLKPSEEKEESSSESGTEEVATVKIQEAEGGLIKEDGPMIHTPL 4249

Query: 809  VDP--REHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESD-FVVLENEGPHRRLV 865
            VD    E   VH  TS  +  A EV+       WY + + V   + F  L+++  +  ++
Sbjct: 4250 VDTVSEEGDIVHLTTS--ITNAKEVN-------WYFENKLVPSDEKFKCLQDQNTYTLVI 4300

Query: 866  LPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVL------T 919
                     GE+ C A ++      T T     +V  +  V    +    V L      T
Sbjct: 4301 DKVNTEDHQGEYVCEALNDSGK---TATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFT 4357

Query: 920  CEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE--- 975
            CE+   P    +W K G E+ ES    ++    +  L +   Q+ D GEY C+  +E   
Sbjct: 4358 CEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGS 4417

Query: 976  -SASFTVTVTEP----------PVRIIYPRDEVTLIAV 1002
             S + T+TVT P          P R   P++EV L +V
Sbjct: 4418 VSCTATLTVTVPGGEKKVRKLLPERKPEPKEEVVLKSV 4455



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 34/119 (28%), Positives = 55/119 (46%), Gaps = 9/119 (7%)

Query: 7     DQGSPPCFLRFPR---PVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPAD 63
             D+  PP     P+    + V +G   ++   + G+P P + W KG Q+L+ + RL   + 
Sbjct: 16039 DEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKST 16098

Query: 64    GAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
                  L +  A+  D+G Y+ +A+N AGE      V VL+ P       P E P+   G
Sbjct: 16099 DFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG------PPEGPVVISG 16151



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 28/92 (30%), Positives = 48/92 (52%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
           +PP F++  + + V  G++  L+  V G P PVV + + G ++ +S       +G  + L
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSL 161

Query: 70  LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
           L+  A P D+G Y   A N+ G A + A + V
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 195/938 (20%), Positives = 327/938 (34%), Gaps = 198/938 (21%)

Query: 713  SPVHI-LSPQDRVS----LTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKM 766
            +PV I ++P   VS    +T    E V L C +S    P  TWY++  ++E S    +  
Sbjct: 888  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 767  DGRKHRLILPEA-------------------------KVQDSGEFECRTEGVSAFFGVT- 800
                 RL++ EA                          VQ S EFE  T  V+  F    
Sbjct: 948  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1007

Query: 801  ---VQDPPVHIVD---------PREHVFVHAITSECV---------MLACEVDREDAP-V 838
               V+   V + D         P E    + IT   V         +  C+V     P V
Sbjct: 1008 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV 1067

Query: 839  RWYKDGQEVEESDF--VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI---- 892
             W K G  +       V    +    +LV+  T   D GE+  V  ++    + +     
Sbjct: 1068 YWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLE 1127

Query: 893  -----------------TDVSSWIVYPS------GKVYVAAVR---LERVVLTCELCRPW 926
                             T V++++  P       G VY    +    E+ ++  ++ +  
Sbjct: 1128 EADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDT 1187

Query: 927  AEVR-WTKDGEEVVESPALLLQKEDTVRRLVLPAVQL-EDSGEYLCEIDDESASFTVTVT 984
              VR + +D E  + S    L KE   R +     +L E+ GE    +D   +    +  
Sbjct: 1188 VVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGF 1247

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLE--RDG 1041
            +  ++     + +         V   C++S    P + WYKDG  ++  E   ++  +DG
Sbjct: 1248 DSRIKNYRILEGMG--------VTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1299

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             R  L +P   PED G +   A +             +  V PAA       GAP  +  
Sbjct: 1300 -RASLRIPVVLPEDEGIYTAFASNIKG----NAICSGKLYVEPAA-----PLGAPTYIPT 1349

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
               V+   S          +  S A    A      ++     P    E   E++ E + 
Sbjct: 1350 LEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERL- 1408

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV---VWSHNGRP-VQEGE 1217
            +  +    PV F  LE   +              +L   G P+    W H+G+  V +  
Sbjct: 1409 YKPVFVLKPVSFKCLEGQTARF------------DLKVVGRPMPETFWFHDGQQIVNDYT 1456

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYT--CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
               +  E   + L I  A P+ +G +T   Q+ A   + S+  TV+  E  V+ +  E  
Sbjct: 1457 HKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKL 1516

Query: 1276 QTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA--SQGRVQLEQAGARQVLRVQGAR 1332
            +  V    G  LE+ V  +G P   + W K+ + +      ++++E       L++    
Sbjct: 1517 K-NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTV 1575

Query: 1333 SGDAGEY----LCDAPQDSRIFLVSVE-----------------------------EPLL 1359
            S D+  Y    +  A +D+    V+VE                             EPL 
Sbjct: 1576 SQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLH 1635

Query: 1360 VKLVSE---------------------LTPLTVHEGDDATFRCEVSP---PDADVTWLRN 1395
            ++   E                     LT L +     A F C ++P   P   V WL +
Sbjct: 1636 LRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHD 1695

Query: 1396 GAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLF 1451
            G  +    ++ M        L        D+G +T RA    G+  TSA L V++ + L 
Sbjct: 1696 GKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSL- 1754

Query: 1452 LRRLQDVRAEEGQDVCLEV-ETGRVGAAGAVRWVRGGQ 1488
               +++ +  EG+     + E  R+   GA+  V   Q
Sbjct: 1755 ---VEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQ 1789



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 67/309 (21%), Positives = 111/309 (35%), Gaps = 55/309 (17%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA----------EDGP 188
            +L G  V   C+  G P P + W KDG  +          LQ GRA          ++G 
Sbjct: 1256 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1315

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ----PPESPPADPDEAPAPV 244
              + A  I    +    +YV  A           L  V +     P S    P       
Sbjct: 1316 YTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR 1375

Query: 245  VEPLKCAPK----------------------------------TFWVNEGKHAKFRCYVM 270
            + P + +P                                   +F   EG+ A+F   V+
Sbjct: 1376 MSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVV 1435

Query: 271  GKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLS 330
            G+P PE  W  +G+ ++ D    +    DG   L ++     D G +   A+N AG++  
Sbjct: 1436 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1495

Query: 331  AVQLHVK----EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRK 385
            +V L V+    + +  F   L++V  +E     ++ +   +  P   W +    ++P  K
Sbjct: 1496 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVP-HK 1554

Query: 386  YEQIE-EGT 393
            Y +I  EGT
Sbjct: 1555 YPKIRIEGT 1563



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 1/93 (1%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            +++++G    +  VV G P P  VW K   +L   +R+     G +  L++  AL  D G
Sbjct: 8617 IQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELD-KDRVVIDNVGTKSELIIKDALRKDHG 8675

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
             YV  A N+ G  +AAA V V + P    +L+P
Sbjct: 8676 RYVITATNSCGSKFAAARVEVFDVPGPVLDLKP 8708



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 1/105 (0%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             S +    P F+  PR   +  G      C + GEP P + W K    ++ S  +S     
Sbjct: 26630 SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR 26689

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP 109
               + L +  A  +D+G Y  +A+N  G+  A A++ VL P   +P
Sbjct: 26690 NVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL-PLVEEP 26733



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 45/157 (28%), Positives = 63/157 (40%), Gaps = 16/157 (10%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + V + +GA   L   V G PPPV+ W K G  LA+  R       +   L++      D
Sbjct: 22957 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYD 23014

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS-------PGSGEGAPV-- 129
             AG Y   A N +G+  A   V V + P   P ++  E    S       P    GAPV  
Sbjct: 23015 AGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNN 23074

Query: 130   FLTGPRSQWVLRGAEVVLTC-----RAGGLPEPTLYW 161
             ++   R   +     V   C     R  GL E T+Y+
Sbjct: 23075 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYY 23111



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 13/178 (7%)

Query: 1640 VTEGDTATFECELSQ-ALADVTWEKDGNALTPS--PRLRLQALGTRRLLQLRRCGPSDAG 1696
            V EG TATFE  +S   + +V+W +DG  ++ S  P +++     R  L +     +++G
Sbjct: 17   VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76

Query: 1697 TYSCAV--GTARA-GPVRLTVRERTVA--VLSELRSVSAREGDGATFECTVSEVET-TGR 1750
             YS     G+ +A     L V+  T     +  L+S++ R+G     +  V+ + T   +
Sbjct: 77   RYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVK 136

Query: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVE 1804
            +   G  ++     +I QEG  + L+++E   ED+G     A    G A S A L V+
Sbjct: 137  FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 4/97 (4%)

Query: 11    PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
             PP F        V++G + ++    +G P P V W K    L  + R++  A+  E+  L
Sbjct: 15650 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN--AESTENNSL 15707

Query: 71    LTA--ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             LT   A   D G YV +  N+AGEA     V VL+ P
Sbjct: 15708 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15744



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 58/264 (21%), Positives = 108/264 (40%), Gaps = 22/264 (8%)

Query: 1631  IVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRR 1689
             IV G  D  V+    A F  + + +      W KDG A+T   + +L        L++ +
Sbjct: 26357 IVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHK 26416

Query: 1690  CGPSDAGTYSCAVGTARAGPVRLTVRERTVAVL-SELRSVSAREGDGATFECTVSEVETT 1748
                SD+G Y+C V  + AG V  + +    A+  +E + VS ++    T E T  + +  
Sbjct: 26417 TDTSDSGLYTCTVKNS-AGSVSSSCKLTIKAIKDTEAQKVSTQK----TSEIT-PQKKAV 26470

Query: 1749  GRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE--DAGEVRFQAGPAQSLALLEVEAL 1806
              + E+  + LR    +++ +   +  L L E  ++   + EV+  A  +   +++  E  
Sbjct: 26471 VQEEISQKALR-SEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEIT 26529

Query: 1807  PLQMCRHPPR----------EKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEM 1856
                      R          + ++  G+R VL+  ++     V W+  G EL   ++Y  
Sbjct: 26530 KTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDVKWVLNGVELTNSEEYRY 26588

Query: 1857  RSHGPTHSLVIHDVRPEDQGTYCC 1880
                G   +L I      D+G   C
Sbjct: 26589 GVSGSDQTLTIKQASHRDEGILTC 26612



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 180/863 (20%), Positives = 317/863 (36%), Gaps = 125/863 (14%)

Query: 228   QPPESPPADP--DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
             +P ES  A    DE   P +        T  V+ G+  K    + GKP P I+W  +G  
Sbjct: 16027 EPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWI-KGDQ 16085

Query: 286   LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV--------- 336
              L +  RL  +  D    L V      D G Y+  A+N AG+    V + V         
Sbjct: 16086 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16145

Query: 337   ---------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYE 387
                      ++  L +  PLQD  G    I  +  +   SR+       + + L C+  +
Sbjct: 16146 PVVISGVTAEKCTLAWKPPLQD--GGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16203

Query: 388   QIE--EGTVRRLIIHRLKADDD---------GIYLCEMRGRVRTVANVTVKGPILKRLPR 436
              +E  E T R + +++    +            ++     +   V  VT    I+     
Sbjct: 16204 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVW--- 16260

Query: 437   KLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQSSSGHMHALVLPGVTRED---- 491
             +    +G + +L     +   EG RW+R  + L        G +   V   +   D    
Sbjct: 16261 ERPASDGGSEILGYVLEKRDKEGIRWTRCHKRL-------IGELRLRVTGLIENHDYEFR 16313

Query: 492   -AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP--EPAPETP 548
              + E    L      +  +  C     PGPP   ++    +++V L+W  P  +   E  
Sbjct: 16314 VSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQ 16373

Query: 549   FIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHG 608
               Y +E+ +V   +W  C          +  + +  + +Y FRIC ++  G   H    G
Sbjct: 16374 G-YIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPG 16432

Query: 609   SAHLVPTARLVAGLEDVQV----YDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVE 664
                ++   +L A   D+ +         A  SL L   I+G       E+K  + +G++ 
Sbjct: 16433 P--IIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGR---PTPEVKWGKVDGEIR 16487

Query: 665   PGALRYRIEQKGLQHRLILHAVKHQDSG--ALVGFSCPGVQDSAALTIQ--ESPVHILSP 720
               A+   I+       L+L  V   DSG   L   +  G + SA +T++  ++P    SP
Sbjct: 16488 DAAI---IDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTK-SAFVTVRVLDTP----SP 16539

Query: 721   QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG-RKHRLILPEAK 779
                + +T  T + V +T E   +D        G K++    +V K +  RK    +    
Sbjct: 16540 PVNLKVTEITKDSVSITWEPPLLD-------GGSKIK--NYIVEKREATRKSYAAVVTNC 16590

Query: 780   VQDSGEFECRTEGVSAFFGVTVQDP-----PVHIVDPREHVFVHAITSECVMLACEVDRE 834
              ++S + +   EG S +F VT ++      P    DP +   V     +  +   +V R 
Sbjct: 16591 HKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGK--ITVDDVTRN 16648

Query: 835   DAPVRWYK----DGQEVEESDFVVLENEGPH----------RRLVLPATQPSDGGE--FQ 878
                + W K     G ++ +    ++E +  H          + L    T  + G E  F+
Sbjct: 16649 SVSLSWTKPEHDGGSKIIQ---YIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFR 16705

Query: 879   CVAGDE--------CAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVR 930
              VA +E         A   V    V    V P+   Y   V  +  +      RP   + 
Sbjct: 16706 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 16765

Query: 931   WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY----LCEIDDESASFTVTVTEP 986
             WTKDG  + ++  + +     +  L +     +D G+Y       +  ++AS  +   + 
Sbjct: 16766 WTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 16825

Query: 987   PVRIIYPRDEVTLIAVTLECVVL 1009
             P     P+  V    V+ E + L
Sbjct: 16826 PDP---PKGPVKFDDVSAESITL 16845



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 44/198 (22%), Positives = 77/198 (38%), Gaps = 24/198 (12%)

Query: 1100  ELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHE 1158
             +L C++       ++WY+ G E+  S   ++ ++G T TLT+   + ED G Y C     
Sbjct: 24054 QLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC----- 24108

Query: 1159  AITFNVILAEPPVQFLALETTPSPLCVAPGEPV----------VLSCELSRAGAPV---V 1205
              I  N +        L L+ TP      PG P+           L   +   G PV    
Sbjct: 24109 -IATNEVGEVETSSKLLLQATPQ---FHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 24164

Query: 1206  WSHNGRPVQEGEGLEL-HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
             W H  + +Q  E + + + E    ++        HAG Y  Q     G       V++ +
Sbjct: 24165 WFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 24224

Query: 1265  PPVRVVAPEAAQTRVRST 1282
              P +   P   +  ++++
Sbjct: 24225 KPDKPTGPIVIEALLKNS 24242



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 40/149 (26%), Positives = 68/149 (45%), Gaps = 13/149 (8%)

Query: 925  PWAEVRWTKDGEEVVES--PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVT 982
            P  EV W +DG+ +  S  P + +   D   +L +PAV   +SG Y  +  + S   T T
Sbjct: 33   PVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATST 92

Query: 983  V-------TEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEA 1034
                    T PP   +     +T+   +   V L   ++    PV ++Y+DG E++ S  
Sbjct: 93   AELLVKAETAPP-NFVQRLQSMTVRQGSQ--VRLQVRVTGIPTPVVKFYRDGAEIQSSLD 149

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
              + ++G    L++  A PED G +  +A
Sbjct: 150  FQISQEGDLYSLLIAEAYPEDSGTYSVNA 178



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 75/330 (22%), Positives = 128/330 (38%), Gaps = 32/330 (9%)

Query: 516  SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIE-KAG 573
            SPP PP+   +    +  + + WKPPE    +P I Y +E   VG+E W++  S   K  
Sbjct: 7786 SPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDL 7845

Query: 574  AVEVPGDCVPSEGDYRFRICTVSGHGRS-PHVVFHGSAHLVPTARLVAGLE--DVQVYDG 630
              +V    VP + +Y  R+  V+  G S P  +        P  +    LE  D+ V +G
Sbjct: 7846 KFKVEEGVVPDK-EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEG 7904

Query: 631  EDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKH 688
            E     +    +   T  W  +G+E+K+++          R  ++   +   L +     
Sbjct: 7905 EKLSIPVPFRAVPVPTVSWHKDGKEVKASD----------RLTMKNDHISAHLEVPKSVR 7954

Query: 689  QDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVD--FP 746
             D+G +   +      SA  +I    + +  P   +  +  T     LT E    D   P
Sbjct: 7955 ADAG-IYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTP 8013

Query: 747  ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFG-------- 798
               Y   ++       +  M G +++L      +  +GE+  R + V+   G        
Sbjct: 8014 ILHYVLERREAGRRTYIPVMSG-ENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8072

Query: 799  -VTVQDPPVHIVDPREHVFVHAITSECVML 827
             V  QDP     DP   V VH  T+E + +
Sbjct: 8073 PVIAQDPK-QPPDPPVDVEVHNPTAEAMTI 8101



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 40/81 (49%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G   +++  VLG P P V W+KG Q L  ++R++F        L +   + +D+G Y  
Sbjct: 14582 AGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPL 14641

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
              ARN  GE      + V + P
Sbjct: 14642 TARNIVGEVGDVITIQVHDIP 14662



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 127/603 (21%), Positives = 215/603 (35%), Gaps = 98/603 (16%)

Query: 37    GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
             G P   V W K GQ L  + R++  +      L +  A   D G Y     N+AG     
Sbjct: 18923 GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 18982

Query: 97    AAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQWVLRGAEVVLTCRAGGLP 155
               + VL+ P     ++  E    S       P +  G + S +++   E   T       
Sbjct: 18983 ITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTT------ 19036

Query: 156   EPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVY---VCHAR 212
                  W     A+                     A  +++I+  RL     Y   VC A 
Sbjct: 19037 -----WHIVSQAV---------------------ARTSIKIV--RLTTGSEYQFRVC-AE 19067

Query: 213   NAHG---HAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFW---VNEGKHAKFR 266
             N +G   ++++ A+  V + P SPP  P      VV   K      W   VN+G      
Sbjct: 19068 NRYGKSSYSESSAV--VAEYPFSPPGPP--GTPKVVHATKSTMLVTWQVPVNDGGSRVIG 19123

Query: 267   CYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA------ 320
              ++  K    I W    + L+ D + +     D G + +         G+  C+      
Sbjct: 19124 YHLEYKERSSILWSKANKILIADTQ-MKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPV 19182

Query: 321   -ARNSA---GQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRE 376
              AR+     GQ      +  K   L++++P  D   +  G  V   ++P           
Sbjct: 19183 PARDPCDPPGQP-EVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELP----------- 19230

Query: 377   DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVK-GPILKR-- 433
             D R L C  Y  I+E       +  L  D    +    R    +V+  +   GPI+ +  
Sbjct: 19231 DGRWLKCN-YTNIQETYFE---VTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDD 19286

Query: 434   --LPRKLDVLEGENAVLL----VETLEAGVEGR------WSRDGEELPVICQS---SSGH 478
                PR +  ++  + +++    V  + A + GR      W++DG E+    ++   S+ +
Sbjct: 19287 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN 19346

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLT 537
                L +    R D G+   +L N   T  + V C     PGPP       G       L+
Sbjct: 19347 HTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 19406

Query: 538   W-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS 596
             W +P E        Y +E++E     W  C    +  + +V    +    +Y FR+  V+
Sbjct: 19407 WGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTK--LLKGNEYIFRVTGVN 19464

Query: 597   GHG 599
              +G
Sbjct: 19465 KYG 19467



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 24/85 (28%), Positives = 43/85 (50%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             V + +G++  L   V G+P P ++W KG ++L   E++S    G     ++     +D+G
Sbjct: 22560 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSG 22619

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y    +NA+G    +  V VL+ P
Sbjct: 22620 KYTLTVKNASGTKAVSVMVKVLDSP 22644



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 87/433 (20%), Positives = 168/433 (38%), Gaps = 45/433 (10%)

Query: 516   SPPGPPILA-EMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAG 573
             +PP PP    E+    K++V L+W +P +        Y +ER+E  ++ W++    +   
Sbjct: 23830 NPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITT 23889

Query: 574   AVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLE--DVQVYDGE 631
              +      VP + +Y+FRI   +  G S            P +  V   +  D     GE
Sbjct: 23890 TMYTVTGLVP-DAEYQFRIIAQNDVGLS---------ETSPASEPVVCKDPFDKPSQPGE 23939

Query: 632   DAVFSLDLSTII--------QGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLIL 683
               + S+   ++          G   + G  ++  +        + + RI+ K      +L
Sbjct: 23940 LEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLL 23999

Query: 684   HAVKHQD---SGALVGFSCP---GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
              A +++    +    G S P    +     LT  E+P      +D   +T    E   L+
Sbjct: 24000 EATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD---VTTKLGEAAQLS 24056

Query: 738   CELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC----RTEG 792
             C++     P   WY+ G+++ +S    +  DGR H L +   + +D G + C        
Sbjct: 24057 CQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGE 24116

Query: 793   VSAFFGVTVQ-DPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESD 851
             V     + +Q  P  H   P +  +  A+ S   +    + R    + W+   + ++ S+
Sbjct: 24117 VETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSE 24176

Query: 852   FVVLENEGPHRRLVLPATQ-PSDGGEFQC----VAGDECAYFTVTITDVSSWIVYPSGKV 906
              + +EN   +  LV+   Q  +  G+++     V G   A   V I D       P+G +
Sbjct: 24177 NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPD---KPTGPI 24233

Query: 907   YVAAVRLERVVLT 919
              + A+     V++
Sbjct: 24234 VIEALLKNSAVIS 24246



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 42/188 (22%), Positives = 74/188 (39%), Gaps = 10/188 (5%)

Query: 1638  LEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             + + EG     +  ++ A  DV W  +G  LT S   R    G+ + L +++    D G 
Sbjct: 26551 MSINEGQRLVLKANIAGA-TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGI 26609

Query: 1698  YSCAVGTARAGPVR----LTVRER---TVAVLSELRSVSAREGDGATFECTVS-EVETTG 1749
              +C +   + G V+    LT+ +      A +S+ RS +  EG    F C +S E     
Sbjct: 26610 LTC-ISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEI 26668

Query: 1750  RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
              W     P+   + V I +    + L +      D+G+   +A   +         + L 
Sbjct: 26669 EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP 26728

Query: 1810  MCRHPPRE 1817
             +   P RE
Sbjct: 26729 LVEEPSRE 26736



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 2/100 (2%)

Query: 8    QGSPPCFL--RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA 65
            Q +P  FL  +    + V +G + EL   V G+P P + W K    L   +R++      
Sbjct: 7188 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPK 7247

Query: 66   EHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
            +  + +  +  +D G Y+  A N  G A A   V VL+ P
Sbjct: 7248 KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP 7287



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/147 (23%), Positives = 67/147 (45%), Gaps = 6/147 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DG+ L    +   SSS  + +L +   ++ED G     + NS  +  + +  +    
Sbjct: 18931 WRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDR 18990

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP    + +   +++ ++W PPE         Y +E++E  S  W          +++
Sbjct: 18991 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19050

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH 603
             +      SE  Y+FR+C  + +G+S +
Sbjct: 19051 IVRLTTGSE--YQFRVCAENRYGKSSY 19075



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 60/268 (22%), Positives = 101/268 (37%), Gaps = 48/268 (17%)

Query: 1300  VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQD-------SRIFLV 1352
             V WY    +L +  + ++       +L V+     D G Y C    D       + +F+ 
Sbjct: 25103 VTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK 25162

Query: 1353  SVEEPL-------------------LVKLVSELT-PL---TVHEGDDATFRCEVSP-PDA 1388
              V E                     L++   E T PL   T + G++  F   ++  P+ 
Sbjct: 25163 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEP 25222

Query: 1389  DVTWLRNGAVVTPGPQVEMAQNGSSR---ILTLRGCQLGDAGTVTLRA----GSTATSAR 1441
              VTW ++G  + PG   +     S +    LT+      D    T+ A    G  +  A+
Sbjct: 25223 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 25282

Query: 1442  L----HVRETEL----LFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHD 1493
             L    H   T+     +F R L +   +EGQ VC E+    +     ++W + GQPL   
Sbjct: 25283 LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGI-PPPTLKWEKDGQPLSLG 25341

Query: 1494  SRLSMAQDG-HIHRLFIHGVILADQGTY 1520
               + +  +G   + L I   +  D G Y
Sbjct: 25342 PNIEIIHEGLDYYALHIRDTLPEDTGYY 25369



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 19/187 (10%)

Query: 1725 LRSVSAREGDGATFECTVS-----EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
            L+SV   EG  ATFE  +S     EV      ++      PG ++    +G+  + + + 
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDGRAKLTIPAV 70

Query: 1780 LRAEDAGEVRFQA----GPAQSLA--LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS 1833
             +A ++G    +A    G A S A  L++ E  P    +   +  TV  G +  L+V V+
Sbjct: 71   TKA-NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL-QSMTVRQGSQVRLQVRVT 128

Query: 1834 RSGGHVC-WLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTH 1888
                 V  + R+GAE+     +++   G  +SL+I +  PED GTY   A    G+ ++ 
Sbjct: 129  GIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATST 188

Query: 1889 TRLLVEG 1895
              LLV+G
Sbjct: 189  AELLVQG 195



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 5/88 (5%)

Query: 1812  RHPPREKTVLVGRRAVLEVT-VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDV 1870
             R   ++ T  +G  A L    V R    + W R G EL    KY+M S G TH+L +   
Sbjct: 24039 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTE 24098

Query: 1871  RPEDQGTYCC----QAGQDSTHTRLLVE 1894
               ED+G Y C    + G+  T ++LL++
Sbjct: 24099 EQEDEGVYTCIATNEVGEVETSSKLLLQ 24126



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 25/93 (26%), Positives = 44/93 (47%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
            V+ G +  +       P P V W K G+++ AS+RL+   D     L +  ++  DAG+Y
Sbjct: 7901 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 7960

Query: 83   VCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
                 N  G A A+  V V+  P    +++ ++
Sbjct: 7961 TITLENKLGSATASINVKVIGLPGPCKDIKASD 7993



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 26/85 (30%), Positives = 40/85 (47%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
             + V  G    +   V G P P + W K G+ L   +R+    D     L +  A+  D G
Sbjct: 11421 ITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 11480

Query: 81    VYVCRARNAAGEAYAAAAVTVLEPP 105
              Y+  A+N++G A  +A V VL+ P
Sbjct: 11481 KYIISAKNSSGHAQGSAIVNVLDRP 11505



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 33/101 (32%), Positives = 42/101 (41%), Gaps = 2/101 (1%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVW--EKGGQQLAASERLSFPADG 64
             D   P   L+    + V +G    L+  V G+P P V W  +K    L  S R+      
Sbjct: 11700 DLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA 11759

Query: 65    AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                   LT A  +D G YV  A N AG   A A V VL+ P
Sbjct: 11760 DSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKP 11800



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 40/149 (26%), Positives = 63/149 (42%), Gaps = 8/149 (5%)

Query: 461   WSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             WS+ G+++    +   +S+     L +   TR+DAGE T +  N   T +  VK      
Sbjct: 13916 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDV 13975

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPF-IYRLERQEVGSEDW-IQCFSIEKAGAV 575
             PGPP   E+         LTW PP     +P   Y LE++E     W +    I+    V
Sbjct: 13976 PGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHV 14035

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                   +    +Y FR+  V+ +G+   V
Sbjct: 14036 ATK---LIQGNEYIFRVSAVNHYGKGEPV 14061



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 1/91 (1%)

Query: 248   LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKV 306
             ++  P    ++EGK     C   G+P PE+ W   GR +   ++ R    + D    L +
Sbjct: 26834 IEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLII 26893

Query: 307   LYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             +  Q +D GLY  +  N  G   + V +H++
Sbjct: 26894 MDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 26924



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 83/382 (21%), Positives = 142/382 (37%), Gaps = 51/382 (13%)

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
            LV+    R D G  T  L N   T    +     + P  P   +     K++V LTW+PP
Sbjct: 6955 LVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPP 7014

Query: 542  EPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS--GH 598
            +    +P   Y +E++EV  + W +           VP D V  + +Y F++C  +  G 
Sbjct: 7015 DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP-DLVQGK-EYLFKVCARNKCGP 7072

Query: 599  GRSPHV---VFHGSAHLVP-----------TARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
            G   +V   V   +   VP           TA  +    D    DG   +    +    +
Sbjct: 7073 GEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPR 7132

Query: 645  GT--WFLNGEELKSNEPE--GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP 700
            G+  W   GE +   + E  G  E     YR++    Q                 G S P
Sbjct: 7133 GSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQ-----------------GASKP 7175

Query: 701  G--VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVE 757
                ++  A+  QE+P   L  +    LT     ++ L   ++    P  TW K    ++
Sbjct: 7176 SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILK 7235

Query: 758  ESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDPPVHIVDPRE 813
            + + + ++   +K  + + ++K  D+G +      V    +A   V V D P     P  
Sbjct: 7236 QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP----GPPA 7291

Query: 814  HVFVHAITSECVMLACEVDRED 835
               +  +T+E  +L     R+D
Sbjct: 7292 AFDITDVTNESCLLTWNPPRDD 7313



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 38/163 (23%), Positives = 62/163 (38%), Gaps = 16/163 (9%)

Query: 7     DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
             +Q  PP  L  P  + + +G +  ++  V G+P P   W+KG  ++  S  L+     + 
Sbjct: 12398 EQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS 12456

Query: 67    HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS----------DPELQPAER 116
               L++      D+G Y   A N++G       V V++ P            D +      
Sbjct: 12457 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSW 12516

Query: 117   PLPSPGSGEGAPVFLTG----PRSQWVLRGAEVVLT-CRAGGL 154
              +P    G     ++       R  WV   A V  T CR G L
Sbjct: 12517 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKL 12559



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 117/570 (20%), Positives = 217/570 (38%), Gaps = 77/570 (13%)

Query: 345   RPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLK 403
             + ++DV  +    A L C++    +P   W+R  + L+  RKY+   +G    L +   +
Sbjct: 24040 KEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEE 24099

Query: 404   ADDDGIYLCEMRGRVRTVANVTVKGPILKRLPR---------KLDVLEGENAVLLVETLE 454
              +D+G+Y C     V  V   T    +L+  P+         K     G    L V  + 
Sbjct: 24100 QEDEGVYTCIATNEVGEVE--TSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIG 24157

Query: 455   AGVEGRWSRDGEEL----PVICQSSSGHMHALVLPGVTRED-AGEVTFSLGNSRTTTL-- 507
               V       G++L      I   ++ H   LV+  V R+  AG+    L N   T    
Sbjct: 24158 RPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAI 24217

Query: 508   --LRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE-----TPFIYRLERQEVGS 560
               + ++     P GP ++  + K   N+ +++WKP  PA +     T ++      + G+
Sbjct: 24218 LDVEIQDKPDKPTGPIVIEALLK---NSAVISWKP--PADDGGSWITNYVVEKCEAKEGA 24272

Query: 561   EDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP-----HVVFHGSAHLVPT 615
             E W    S        +    +     Y FR+   +  G S       VV   S    P 
Sbjct: 24273 E-WQLVSSAISVTTCRIVN--LTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG 24329

Query: 616   ARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT----WFLNGEELKSNE----PEGQVEPGA 667
             A    G   +     +  V +        G     ++L   E K N+       ++    
Sbjct: 24330 A---PGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETV 24386

Query: 668   LRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSP---QDRV 724
                +   +GL++      VK ++ G    +S    + S  +T  +S V I +P   ++  
Sbjct: 24387 FSVKNLIEGLEYEF---RVKCENLGGESEWS----EISEPIT-PKSDVPIQAPHFKEELR 24438

Query: 725   SLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELL--VVKMDGRKHRLILPEAKVQ 781
             +L         L C+++    P   WY+ G+++    L   + +  G  H+LI+      
Sbjct: 24439 NLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDD 24498

Query: 782   DSGEFECRTEG----VSAFFGVTVQDPP-VHIVDPREHV-FVHAITSECVMLACEVDRED 835
             D+  ++ R       VS    + V+ P  +H+    E +  VHA+  E V +      + 
Sbjct: 24499 DATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKP 24558

Query: 836   APVRWYKDGQEVEESDFVVLENEGPHRRLV 865
              PV  ++ GQ+       +++N G ++ +V
Sbjct: 24559 DPVITWQKGQD-------LIDNNGHYQVIV 24581



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 60/287 (20%), Positives = 101/287 (35%), Gaps = 49/287 (17%)

Query: 1461  EEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
             EEG  V    +      +  V W  G + L +  +  +  +  +  L++  +   D GTY
Sbjct: 25083 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 25142

Query: 1521  GCESHHD------------------------RTLARLSVRPRQLRVLRPLEDVTISEGGS 1556
              C+  +D                        RT+ ++  R   +R+L    + T+     
Sbjct: 25143 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 25202

Query: 1557  ATFQLELSQEGVT--------GEWARGGVQLYPG---PKCHIHSDGHRHRLVLNGLGLAD 1605
               +  E  + GVT          W + G ++ PG    K    SD   ++L +N +   D
Sbjct: 25203 TAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDD 25262

Query: 1606  SGCVSFTA------DSLRCAARLIVREVPVTIVRGP------HDLEVTEGDTATFECELS 1653
                 +  A      DS +    + +   P      P       + E  EG +  FE  +S
Sbjct: 25263 DAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVS 25322

Query: 1654  Q-ALADVTWEKDGNALTPSPRLRLQALG-TRRLLQLRRCGPSDAGTY 1698
                   + WEKDG  L+  P + +   G     L +R   P D G Y
Sbjct: 25323 GIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 25369



 Score = 44.7 bits (104), Expect = 9e-04
 Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 6/107 (5%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             +F   + V +G    L+  V G+P P + W +G +++  S R        +  L++  A+
Sbjct: 17133 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAI 17192

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
               D G Y+ RA N AG       V VL+ P       P E P+   G
Sbjct: 17193 RIDGGQYILRASNVAGSKSFPVNVKVLDRPG------PPEGPVQVTG 17233



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 17/180 (9%)

Query: 1284 GGDLELVVHLSG-PGGPVRWYKDGERLASQGR--VQLEQAGARQVLRVQGARSGDAGEYL 1340
            G       H+SG P   V W++DG+ +++     VQ+  +  R  L +      ++G Y 
Sbjct: 20   GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79

Query: 1341 CDAPQDSRIFLVSVEEPLLVK-------LVSELTPLTVHEGDDATFRCEVSP-PDADVTW 1392
              A   S     + E  LLVK        V  L  +TV +G     +  V+  P   V +
Sbjct: 80   LKATNGSGQATSTAE--LLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKF 137

Query: 1393 LRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETE 1448
             R+GA +      +++Q G    L +      D+GT ++ A    G   ++A L V+  E
Sbjct: 138  YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEE 197



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 29/110 (26%), Positives = 43/110 (39%), Gaps = 2/110 (1%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P   R   P+ V  G  A+  C +   P     W K G+++  S++ S  +      L +
Sbjct: 4337 PVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEI 4396

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDP--ELQPAERPLP 119
                  D G Y C+A N  G     A +TV  P       +L P  +P P
Sbjct: 4397 LRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPERKPEP 4446



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 23/75 (30%), Positives = 35/75 (46%)

Query: 31    LKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAA 90
             LK  + G+P P V W+KG   LA   R+S  +      L++     +DAG Y    +N A
Sbjct: 13505 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 13564

Query: 91    GEAYAAAAVTVLEPP 105
             G      ++ V+  P
Sbjct: 13565 GTKEGTISIKVVGKP 13579



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 6/104 (5%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   V + +G    L+  V G PPP + W K G++L  + +L          L+   +
Sbjct: 14968 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDS 15027

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL 118
                D+G Y   A N  G A     V VL+ P       P E PL
Sbjct: 15028 TRRDSGAYTLTATNPGGFAKHIFNVKVLDRPG------PPEGPL 15065



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 1/89 (1%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G + ++     G PPP V W K  + L +  R S     +   L +      D G Y+ 
Sbjct: 20788 AGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYIL 20847

Query: 85    RARNAAGEAYAA-AAVTVLEPPASDPELQ 112
                N  GE  ++  +V VL+ PA+  +LQ
Sbjct: 20848 TIENGVGEPKSSTVSVKVLDTPAACQKLQ 20876



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 50/213 (23%), Positives = 75/213 (35%), Gaps = 40/213 (18%)

Query: 1721  VLSELRSVSAREGDGATFECTVSEVE--TTGRWELGGRPLRPGARVRIRQEGKKHILVLS 1778
             V  ++      EG    + C +   +  T   W  G R L    +  I  E    IL + 
Sbjct: 25073 VSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVK 25132

Query: 1779  ELRAEDAGEVRFQA----GPAQSLALLEVEAL--------------------PLQMCRHP 1814
             ++   D G  R +     G   S A L V+ +                     +++   P
Sbjct: 25133 DITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERP 25192

Query: 1815  PR------EKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGD---KYEMRSHGPTHS 1864
             P        KT  VG      VT++     HV W + G ++ PGD   KY   S    + 
Sbjct: 25193 PEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQ 25252

Query: 1865  LVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
             L I+ V  +D   Y   A    G+DS   +L V
Sbjct: 25253 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25285



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 28/91 (30%), Positives = 37/91 (40%), Gaps = 1/91 (1%)

Query: 12    PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE-HGLL 70
             P F R         G     +  V G PPP + WEK GQ L+    +    +G + + L 
Sbjct: 25298 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25357

Query: 71    LTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
             +   LP D G Y   A N AG     A + V
Sbjct: 25358 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 25388



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 32/124 (25%), Positives = 53/124 (42%), Gaps = 3/124 (2%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             L +     ED G  + ++ N   +  + VK +    PGPP   E+ +  K++  LTWK P
Sbjct: 10777 LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEP 10836

Query: 542   -EPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
              +        Y +ER++V S  W    +  K  +       +     Y FR+   + +GR
Sbjct: 10837 LDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH--LNEGNQYLFRVAAENQYGR 10894

Query: 601   SPHV 604
              P V
Sbjct: 10895 GPFV 10898



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 8/90 (8%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
            PPGPP   E+    K+++ L WKPP     +P   Y +E QE G+ DW +   + +   +
Sbjct: 9207 PPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKR---VNEPDKL 9263

Query: 576  EVPGDCVPSE----GDYRFRICTVSGHGRS 601
                +CV         YRFR+  V+  G S
Sbjct: 9264 ITTCECVVPNLKELRKYRFRVKAVNEAGES 9293



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 23/83 (27%), Positives = 32/83 (38%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G       ++ G P P   W   G ++   E  +   D     L +   L  D G Y
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEY 11084

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  NAAG    A  +TVL+ P
Sbjct: 11085 QITVSNAAGSKTVAVHLTVLDVP 11107



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 100/465 (21%), Positives = 172/465 (36%), Gaps = 60/465 (12%)

Query: 1021  RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPER 1080
             +W  DG E++  E   +E D     L +      D GE+     + +   TV V      
Sbjct: 11046 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 11105

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAP--AGSQVRWYKDGLEVEASDALQLGAEGPTRT- 1137
             +  P    +++    P  + +  +      GS V  Y    +    D   + + G ++T 
Sbjct: 11106 VPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTK 11165

Query: 1138  LTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALE-----TTPSPLCVAPGEPVV 1192
             L +PH Q     EYV   R E    N I   PP+           + PSP    PG+PVV
Sbjct: 11166 LKIPHLQK--GCEYVFRVRAE----NKIGVGPPLDSTPTVAKHKFSPPSP----PGKPVV 11215

Query: 1193  LSCELSRAGAPVVW----SHNGRPVQ---------EGEGLELHAEGPRRVLCIQAAGPAH 1239
                +++   A V W    S  G P+           G+ + ++ + P   L  +  G   
Sbjct: 11216 T--DITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVN-KTPIADLKFRVTGLYE 11272

Query: 1240  AGLYTCQ------SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHL 1293
                Y  +      +G +  +PS S  ++   P      P   + + +S    DL     L
Sbjct: 11273 GNTYEFRVFAENLAGLSKPSPS-SDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPL 11331

Query: 1294  SGPGGPVRWY-----KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----- 1343
             S  G P+  Y     K G   A   R+  ++   +   RV G   G+   +   A     
Sbjct: 11332 SDGGSPILGYVVECQKPGT--AQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11389

Query: 1344  ---PQD--SRIFLVSVEEPLLVKL-VSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
                P++    +    +  P  V+L V+    +TV  G        V   P+ D+TW + G
Sbjct: 11390 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11449

Query: 1397  AVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSAR 1441
              V+    +V++ Q+     L ++     D G   + A +++  A+
Sbjct: 11450 KVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQ 11494



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 72/378 (19%), Positives = 127/378 (33%), Gaps = 62/378 (16%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R + V +G    +   + G P P V W K    L    R +     +   L++      D
Sbjct: 14287 RTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINL--KNRANIENTESFTLLIIPECNRYD 14344

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQ 137
              G +V    N AG+      V VL+ P     L+P +    S       P+   G R + 
Sbjct: 14345 TGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITN 14404

Query: 138   WVLRGAEV-------------------------------VLTCRAGGLPEPTLYWEK--- 163
             +++   E                                V+     G+ EPT   E    
Sbjct: 14405 YIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 14464

Query: 164   -------DGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYV-------- 208
                    D + + ++  S+     P    DG G+ +   ++ A+   S  +         
Sbjct: 14465 SEAPSPPDSLNIMDITKSTVSLAWPKPKHDG-GSKITGYVIEAQRKGSDQWTHITTVKGL 14523

Query: 209   -CHARN-AHGHAQAGALLQVHQPPESPPADP------DEAPAPVVEPLKCAPKTFWVNEG 260
              C  RN   G      ++ V+    S P +       ++   P ++      K      G
Sbjct: 14524 ECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAG 14583

Query: 261   KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              + K    V+G+P+P + W  +G  +L   +R+ +       +L +  C   D G Y   
Sbjct: 14584 DNIKVEIPVLGRPKPTVTWK-KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 14642

Query: 321   ARNSAGQTLSAVQLHVKE 338
             ARN  G+    + + V +
Sbjct: 14643 ARNIVGEVGDVITIQVHD 14660



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 24/83 (28%), Positives = 39/83 (46%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + +G + +++  V+G P P + W K G+ L  + R++         L +      D G Y
Sbjct: 17826 IQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKY 17885

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A N+AG A    +V VLE P
Sbjct: 17886 TVTATNSAGTATENLSVIVLEKP 17908



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 22/92 (23%), Positives = 40/92 (43%)

Query: 10    SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
             S P  +   +   V S + A+      GEP P  +W K G+ +    +     D     L
Sbjct: 26353 SKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFL 26412

Query: 70    LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +     +D+G+Y C  +N+AG   ++  +T+
Sbjct: 26413 EIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26444



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 52/216 (24%), Positives = 87/216 (40%), Gaps = 29/216 (13%)

Query: 727 TFTTSERVVLTCELSRVDFPA----------TWYKDGQKVEESELLVVKM---DGRKHRL 773
           TFT   + V+  E S   F A          +W++DGQ +  S L  V++   DGR  +L
Sbjct: 7   TFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA-KL 65

Query: 774 ILPEAKVQDSGEFECRTEGVS------AFFGVTVQDPPVHIVDPREHVFVHAITSECVML 827
            +P     +SG +  +    S      A   V  +  P + V   + + V   +   V L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ--VRL 123

Query: 828 ACEVDREDAPV-RWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
              V     PV ++Y+DG E++ S    +  EG    L++    P D G +   A +   
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183

Query: 887 YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL 922
             T T        +   G+  V A + + +V T ++
Sbjct: 184 RATSTAE------LLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 5/122 (4%)

Query: 219   QAGALLQVHQPPESPPADPDEAPAPVVEP---LKCAPKTFW-VNEGKHAKFRCYVMGKPE 274
             +A A   V+  P S P+DP    A  V P   L  A K+   V  G +      V GKP 
Sbjct: 12768 RAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPM 12827

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P + W  +G  L P     M   R+    L++     KD G Y   A NS+G   + ++L
Sbjct: 12828 PTVSWKKDGTLLKPAEGIKMAMQRN-LCTLELFSVNRKDSGDYTITAENSSGSKSATIKL 12886

Query: 335   HV 336
              V
Sbjct: 12887 KV 12888



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 23/87 (26%), Positives = 34/87 (39%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             + + V +G   EL   + G PPP   W   G +L  SER++         L +      D
Sbjct: 23249 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRD 23308

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPP 105
              G Y    +N  G       V +L+ P
Sbjct: 23309 TGEYTLELKNVTGTTSETIKVIILDKP 23335



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 48/225 (21%), Positives = 86/225 (38%), Gaps = 25/225 (11%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G    L+C+  G P P + W + G    E+  S  + +         G +  L ++    
Sbjct: 24050 GEAAQLSCQIVGRPLPDIKWYRFGK---ELIQSRKYKMS------SDGRTHTLTVMTEEQ 24100

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGK 261
              D GVY C A N  G  +  + L +   P+  P            PLK   + ++   G 
Sbjct: 24101 EDEGVYTCIATNEVGEVETSSKLLLQATPQFHPG----------YPLK---EKYYGAVGS 24147

Query: 262   HAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR-GLYVCA 320
               +     +G+P P + W + G+ LL +   +   + +    L +   Q K   G Y   
Sbjct: 24148 TLRLHVMYIGRPVPAMTW-FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ 24206

Query: 321   ARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVP 365
               N  G   + + + +++   + T P+  +E      AV+  K P
Sbjct: 24207 LSNVFGTVDAILDVEIQDKPDKPTGPIV-IEALLKNSAVISWKPP 24250



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 2/99 (2%)

Query: 5     SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
             +G +G PP     P  + +  G    + C   GEP P V W  GG+++ + E+  F  + 
Sbjct: 26825 AGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIEN 26884

Query: 65    AEH--GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
              +    L++      D G+Y     N  G   A   + +
Sbjct: 26885 TDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 26923



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 25/83 (30%), Positives = 35/83 (42%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             + SG    +K +V G P P V W K G ++     +          L +  A     GVY
Sbjct: 21473 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 21532

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+NA+G A A   V V + P
Sbjct: 21533 TVEAKNASGSAKAEIKVKVQDTP 21555



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 119/577 (20%), Positives = 207/577 (35%), Gaps = 118/577 (20%)

Query: 1111 QVRWYKDGLEVEASDALQLG-AEGPTRTLTLPHAQPEDAGEYVC---ETRHEAITFNVIL 1166
            ++ WYKDG  ++  +  Q+   +    +L +P   PED G Y       +  AI    + 
Sbjct: 1275 KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY 1334

Query: 1167 AEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGP 1226
             EP     A      P  +   EPV      SR  +    S +  P++           P
Sbjct: 1335 VEPAAPLGA------PTYIPTLEPV------SRIRSLSPRSVSRSPIRMSPA----RMSP 1378

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGD 1286
             R+       PA         G        S   ++ +P V V+ P + +     T   D
Sbjct: 1379 ARM------SPARMSPARMSPGRRLEETDESQLERLYKP-VFVLKPVSFKCLEGQTARFD 1431

Query: 1287 LELVVHLSGPGGPVRWYKDGERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAP 1344
            L++V     P     W+ DG+++ +    +V +++ G + ++ V    S D+GE+   A 
Sbjct: 1432 LKVV---GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPS-DSGEWTVVAQ 1487

Query: 1345 QDSRIFLVSV-------EEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
              +    +SV       E  +    V +L  + + EG     +   +  P+ D+ WL+N 
Sbjct: 1488 NRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS 1547

Query: 1397 AVVTPG--PQVEMAQNGSSRILTLRGCQLGDA----GTVTLRAGSTATSARLHVR----- 1445
             ++ P   P++ +        L +      D+     T   +AG   T  +++V      
Sbjct: 1548 DIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAE 1607

Query: 1446 ---ETELLFLR---RLQDVRAEE--------GQDVCLE--------------------VE 1471
               E +L+  R   R +++ A E        GQ+   E                    + 
Sbjct: 1608 PEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1667

Query: 1472 TGRVGAAG-------------AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQG 1518
              R G A               V W+  G+PL   +RL M  +     L        D G
Sbjct: 1668 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSG 1727

Query: 1519 TYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE----LSQEG-VT 1569
               C + +    D T A L V+  +  V    E+  + EG     ++E    ++ EG +T
Sbjct: 1728 IITCRATNKYGTDHTSATLIVKDEKSLV----EESQLPEGRKGLQRIEELERMAHEGALT 1783

Query: 1570 G------EWARGGVQLYPGPKCHIHSDGHRHRLVLNG 1600
            G      E  +  + LYP P   +  +  R R  + G
Sbjct: 1784 GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTG 1820



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 40/139 (28%), Positives = 50/139 (35%), Gaps = 23/139 (16%)

Query: 205  GVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV----EPLKCAPKTFWVNEG 260
            G YVC A N  G     A L V +             APV+    EPL+ A        G
Sbjct: 4310 GEYVCEALNDSGKTATSAKLTVVK-----------RAAPVIKRKIEPLEVAL-------G 4351

Query: 261  KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
              AKF C +   P    +W   GR +  +  +   R       L++L  Q  D G Y C 
Sbjct: 4352 HLAKFTCEIQSAPNVRFQWFKAGREIY-ESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 4410

Query: 321  ARNSAGQTLSAVQLHVKEP 339
            A N  G       L V  P
Sbjct: 4411 ASNEYGSVSCTATLTVTVP 4429



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 79/341 (23%), Positives = 128/341 (37%), Gaps = 51/341 (14%)

Query: 105   PASDPELQPAERPLPSPG----------SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGL 154
             P+SDP    A RP+  PG          S E A +  T P S         V+ C+  G 
Sbjct: 11293 PSSDPI--KACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG- 11349

Query: 155   PEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
                T  W +  +  DE+     F + PG  E   G     RI AA +   G         
Sbjct: 11350 ---TAQWNR--INKDELIRQCAFRV-PGLIE---GNEYRFRIKAANIVGEG-------EP 11393

Query: 215   HGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                A++     +  PPE             VE          V  G+  +    V G+PE
Sbjct: 11394 RELAESVIAKDILHPPE-------------VELDVTCRDVITVRVGQTIRILARVKGRPE 11440

Query: 275   PEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             P+I W  EG+ L+ ++R  + +D      L++      D G Y+ +A+NS+G    +  +
Sbjct: 11441 PDITWTKEGKVLVREKRVDLIQDLP-RVELQIKEAVRADHGKYIISAKNSSGHAQGSAIV 11499

Query: 335   HVKEPRLRFTRPLQDVE----GREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE 390
             +V    L    P Q+++     +E+     E  + N       F  + R    + +  + 
Sbjct: 11500 NV----LDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVA 11555

Query: 391   EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPIL 431
                 +RLI   L A+++  +      +V     +  K PIL
Sbjct: 11556 SDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPIL 11596



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 25/100 (25%), Positives = 41/100 (41%), Gaps = 1/100 (1%)

Query: 239   EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDR 298
             EA   ++ P    P+   +  GK  +   +V GKP P  +W  +G   +     L     
Sbjct: 12395 EAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKA 12453

Query: 299   DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
             D   +L +     KD G Y   A NS+G     +++ V +
Sbjct: 12454 DSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMD 12493



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 1/85 (1%)

Query: 458   EGRWSRD-GEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             E +W+RD GE L      S+     L++  V R D+G+   ++ NS  +    V      
Sbjct: 15394 EVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLD 15453

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPP 541
              PGPP   ++ +  K +V LTW PP
Sbjct: 15454 TPGPPQDLKVKEVTKTSVTLTWDPP 15478



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 34/119 (28%), Positives = 47/119 (39%), Gaps = 11/119 (9%)

Query: 231   ESPPADPDEAPAPVVEP-------LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             E   +DP     PV+         LK    T+ +  G+  K    V+G+P P I W  +G
Sbjct: 17793 EKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDG 17852

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG---QTLSAVQLHVKEP 339
              P L    R+   +     VL +      D G Y   A NSAG   + LS + L    P
Sbjct: 17853 EP-LKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGP 17910



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 23/91 (25%), Positives = 42/91 (46%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             L +   V+  +G   +L+  + G+P P + W K  ++L  +  +          +L+  A
Sbjct: 20379 LEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDA 20438

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
                ++G Y  + RNA G A A   V +L+ P
Sbjct: 20439 DRLNSGCYELKLRNAMGSASATIRVQILDKP 20469



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 21/182 (11%)

Query: 1178 TTPSPLCVAPGEPVVL------SCELSRAGAPVV---WSHNGRPVQEGE--GLELHAEGP 1226
            TT +P    P + VV+      + E   +G PV    W  +G+ +      G+++     
Sbjct: 2    TTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDG 61

Query: 1227 RRVLCIQAAGPAHAGLYTCQ----SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRST 1282
            R  L I A   A++G Y+ +    SG A     L    + A PP  V   ++   R    
Sbjct: 62   RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA-PPNFVQRLQSMTVR---- 116

Query: 1283 PGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
             G  + L V ++G P   V++Y+DG  + S    Q+ Q G    L +  A   D+G Y  
Sbjct: 117  QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176

Query: 1342 DA 1343
            +A
Sbjct: 177  NA 178



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 7/101 (6%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQL-AASERLSFPADGAEHGLLLTAALPTDAGV 81
             V +G    L+  + G+P P VVW K G++L   + R+   +   +  L++   + TD G 
Sbjct: 18222 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 18281

Query: 82    YVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             Y+ +  N  G       V VL+ P       P E PL   G
Sbjct: 18282 YILKLSNVGGTKSIPITVKVLDRPG------PPEGPLKVTG 18316



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 68/300 (22%), Positives = 118/300 (39%), Gaps = 39/300 (13%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAG 573
             SP  PP   +     + T+ L W PP     +  + Y +E+++ G+E W++C F+     
Sbjct: 21356 SPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSEC 21414

Query: 574   AVEVPGDCVPSEGD-YRFRIC------TVSGHGRSPHVVFHGSAHLVPTARLVAGLED-V 625
                V G    S GD Y FRI       T+S   +S  ++     ++ P         D +
Sbjct: 21415 QYTVTG---LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGL 21471

Query: 626   QVYDGEDAVFSLDLSTIIQG------TWFLNGEEL-KSNEPEGQVEPGALRYRIEQKGLQ 678
              +  GE    SL +  ++QG      TWF +G E+ K    E     G+    +      
Sbjct: 21472 IIKSGE----SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRD 21527

Query: 679   HRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTC 738
             HR +        SG+         +    + +Q++P  ++ P   +  T  T E++ L  
Sbjct: 21528 HRGVYTVEAKNASGS--------AKAEIKVKVQDTPGKVVGP---IRFTNITGEKMTLWW 21576

Query: 739   ELSRVD--FPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
             +    D   P T Y   +K E S L    ++ +         K+ +  E++ R   V+ F
Sbjct: 21577 DAPLNDGCAPITHYII-EKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKF 21635



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 38/150 (25%), Positives = 57/150 (38%), Gaps = 30/150 (20%)

Query: 80   GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWV 139
            G YVC A N +G+   +A +TV++  A  P ++    PL                    V
Sbjct: 4310 GEYVCEALNDSGKTATSAKLTVVKRAA--PVIKRKIEPLE-------------------V 4348

Query: 140  LRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAA 199
              G     TC     P     W K G    E+++S   +++  +         +L IL  
Sbjct: 4349 ALGHLAKFTCEIQSAPNVRFQWFKAGR---EIYESDKCSIRSSKYIS------SLEILRT 4399

Query: 200  RLPDSGVYVCHARNAHGHAQAGALLQVHQP 229
            ++ D G Y C A N +G     A L V  P
Sbjct: 4400 QVVDCGEYTCKASNEYGSVSCTATLTVTVP 4429



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 38/252 (15%)

Query: 373  WFREDQRLLPCRKY--EQIEEGTVRRLIIHRLKADDDG-------IYLCEMRGRVRTVAN 423
            W R  ++++  R+Y  ++I EG   +L +  + A  +G       + + E +       +
Sbjct: 8551 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELD 8610

Query: 424  VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGEELPV--ICQSS 475
            V+VKG I         ++ G+        + A V GR      W+++  EL    +   +
Sbjct: 8611 VSVKGGI--------QIMAGKTL-----RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDN 8657

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
             G    L++    R+D G    +  NS  +     +      PGP +  +    ++   L
Sbjct: 8658 VGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVLDLKPVVTNRKMCL 8717

Query: 536  LTWKPPEP---APETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
            L W  PE    +  T FI  +ER++     W Q    E++   ++ G  +    +Y+FR+
Sbjct: 8718 LNWSDPEDDGGSEITGFI--IERKDAKMHTWRQPIETERS-KCDITG--LLEGQEYKFRV 8772

Query: 593  CTVSGHGRSPHV 604
               +  G  P V
Sbjct: 8773 IAKNKFGCGPPV 8784



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 34/112 (30%), Positives = 46/112 (41%), Gaps = 11/112 (9%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    L   V G+P P V W+K G  L  +E +          L L +    D+G Y
Sbjct: 12810 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDY 12869

Query: 83    VCRARNAAGEAYAAAAVTVLE---PPA--------SDPELQPAERPLPSPGS 123
                A N++G   A   + VL+   PPA        SD  +   E PL   GS
Sbjct: 12870 TITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGS 12921



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 22/86 (25%), Positives = 42/86 (48%), Gaps = 1/86 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP   +++   +++V L+W  P     +P I Y +E +   S++W++C   +     
Sbjct: 13091 PPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKT 13150

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
                   +  +  Y+FR+  V+  G S
Sbjct: 13151 RFEVTGLMEDTQYQFRVYAVNKIGYS 13176



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 108/551 (19%), Positives = 196/551 (35%), Gaps = 81/551 (14%)

Query: 418   VRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPVICQ--- 473
             V  +A   V  P  K L     VL GE+  + V  +        W +D   L    +   
Sbjct: 15640 VPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNA 15699

Query: 474   SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPI-LAEMFKGHKN 532
              S+ +   L +    RED G     L NS    +  +  +    PGPP    +M +   +
Sbjct: 15700 ESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTAD 15759

Query: 533   TVLLTWKPPE-PAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
             ++ L+W PP+     +   Y +E+++  +  W Q  S   A    +    + +  +Y+FR
Sbjct: 15760 SITLSWGPPKYDGGSSINNYIVEKRDTSTTTW-QIVSATVA-RTTIKACRLKTGCEYQFR 15817

Query: 592   ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNG 651
             I   + +G+S ++    +    P               G      + LS+        + 
Sbjct: 15818 IAAENRYGKSTYLNSEPTVAQYPFK-----------VPGPPGTPVVTLSS-------RDS 15859

Query: 652   EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
              E++ NEP        + Y +E+K  +   IL    ++       F   G+++      +
Sbjct: 15860 MEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFR 15917

Query: 712   ESPVHI--LSPQDRVSLTFTT---------SERVVLTCELSRVDFPATWYKDGQK----- 755
              S  +I  +    +VS  +            E +++T     + +    Y  G K     
Sbjct: 15918 VSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYI 15977

Query: 756   VEESELLVVKMDGR---------------------KHRLILPEAKVQDSGEFECRTEGVS 794
             VE+ EL     +GR                      HR          +G F   +E   
Sbjct: 15978 VEKKEL----PEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTG 16033

Query: 795   AFFGVTVQDPPVHIVDP--REHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESD 851
             A       DPP   +DP  ++ + VHA   E   +  ++  +  P ++W K  QE+  + 
Sbjct: 16034 AITARDEVDPPRISMDPKYKDTIVVHA--GESFKVDADIYGKPIPTIQWIKGDQELSNTA 16091

Query: 852   FVVLENEGPHRRLVLPATQPSDGGEF----QCVAGDECAYFTVTITDVSSWIVYPSGKVY 907
              + +++      L +      D G +    + VAG+      V + D       P G V 
Sbjct: 16092 RLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPG---PPEGPVV 16148

Query: 908   VAAVRLERVVL 918
             ++ V  E+  L
Sbjct: 16149 ISGVTAEKCTL 16159



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 94/441 (21%), Positives = 167/441 (37%), Gaps = 67/441 (15%)

Query: 461   WSRDGEELP--VICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP 518
             WS+ G +L    I  ++  +   L++  V R DAG+ T    N        V    +  P
Sbjct: 22983 WSKQGIDLASRAIIDTTESYS-LLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 23041

Query: 519   GPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEV 577
             GP    ++ +  +++V +TW+ P      P   Y +E++E     +    +        +
Sbjct: 23042 GPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRI 23101

Query: 578   PGDCVPSEGD-YRFRICTVSGHG-----RSPHVVFHGSAHLVP--------TARLVAGLE 623
              G     EG  Y FR+   + +G      +   V      LVP        T   V    
Sbjct: 23102 SGLV---EGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAW 23158

Query: 624   DVQVYDGEDAVFSLDLSTIIQGT--WFLNGEELKSNEPEGQVEPGALRYRIEQ--KGLQH 679
             +  +YDG   +    L     GT  W               ++P  L + +    +G Q+
Sbjct: 23159 EKPLYDGGSRLTGYVLEACKAGTERWM----------KVVTLKPTVLEHTVTSLNEGEQY 23208

Query: 680   RLILHAVKHQDSGALVGFSCPGVQDSAALTIQES---PVHILSPQDRVSLTFTTSERVVL 736
                + A   +      G S P  +   A+T+Q+    P   LS   + ++       V L
Sbjct: 23209 LFRIRAQNEK------GVSEPR-ETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 23261

Query: 737   TCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA 795
                ++    PA +W+  G K+ ESE + V+   +  +L + E  ++D+GE+    + V+ 
Sbjct: 23262 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVT- 23320

Query: 796   FFGVTVQDPPVHIVD----PREHVFVHAITSECVMLACEVDRED--APVRWYKDGQEVEE 849
               G T +   V I+D    P   + +  I +  + ++ E    D  AP+  Y        
Sbjct: 23321 --GTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGY-------- 23370

Query: 850   SDFVVLENEGPHRRLVLPATQ 870
                 V+E    HR   LP ++
Sbjct: 23371 ----VVEQRDAHRPGWLPVSE 23387



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 54/219 (24%), Positives = 82/219 (37%), Gaps = 32/219 (14%)

Query: 127   APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
             AP F    R+  V   +   L C+  G P+P + W + G  +  + D   +     R ++
Sbjct: 24430 APHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEI--IADGLKY-----RIQE 24482

Query: 187   GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
               G    L I +    D+ VY   A N  G     A L+V            E PA +  
Sbjct: 24483 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------------EVPAKI-- 24528

Query: 247   PLKCAPKTFWVNEGKHA------KFRCYVMGKPEPEIEWHWEGRPLLPDRRRL-MYRDRD 299
                  PKT       HA        +    GKP+P I W  +G+ L+ +     +   R 
Sbjct: 24529 ---HLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRS 24584

Query: 300   GGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
                ++     + KD G YV  A+N  G     V+L V +
Sbjct: 24585 FTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 24623



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 58/260 (22%), Positives = 101/260 (38%), Gaps = 55/260 (21%)

Query: 259   EGKHAKFRCYVMGKPEP-EIEWHWEGRPLL-PDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             EG H K+ C +    +  ++ W++  R L   ++  + Y D  G  +L V      D G 
Sbjct: 25084 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED--GVAILYVKDITKLDDGT 25141

Query: 317   YVCAARNSAGQTLSAVQLHVKEPRLRF----TRPLQDVEGREHGIAVLECKVPNSRIP-- 370
             Y C   N  G+  S  +L VK  R  +     R ++ ++ R   + +LE + P   +P  
Sbjct: 25142 YRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLE-RPPEFTLPLY 25200

Query: 371   -----------------------TAWFREDQRLLP---CRKYEQIEEGTVRRLIIHRLKA 404
                                      W++  Q++ P    +KY    +  + +L I+ +  
Sbjct: 25201 NKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTT 25260

Query: 405   DDDGIYLCEMR---GRVRTVANVTVK----------GPILKRLPRKLDVLEGENAVLLVE 451
             DDD  Y    R   G     A +TV            P+ KRL    +  EG++  +  E
Sbjct: 25261 DDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQS--VCFE 25318

Query: 452   TLEAGVEG---RWSRDGEEL 468
                +G+     +W +DG+ L
Sbjct: 25319 IRVSGIPPPTLKWEKDGQPL 25338



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 45/169 (26%), Positives = 63/169 (37%), Gaps = 38/169 (22%)

Query: 85   RARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAE 144
            RA NAAG         + EP  + P  +  + P+ +P       V L    S  V RG E
Sbjct: 8158 RAENAAG---------ISEPSRATPPTKAVD-PIDAP------KVILR--TSLEVKRGDE 8199

Query: 145  VVLTCRAGGLPEPTLYWEKDGMAL-----------------DEVWDSSHFAL---QPGRA 184
            + L     G P PT+ W KD   +                  EV +   F L   Q    
Sbjct: 8200 IALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSI 8259

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
            ++       LR+  +  PD G+Y+    N HG A+A   + V   P  P
Sbjct: 8260 DNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPP 8308



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 6/145 (4%)

Query: 914   ERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC-- 970
             E   L+C++  RP  +++W + G+E+++S    +  +     L +   + ED G Y C  
Sbjct: 24051 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24110

Query: 971   --EIDD-ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGL 1027
               E+ + E++S  +    P     YP  E    AV     + +  + R    + W+    
Sbjct: 24111 TNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQK 24170

Query: 1028  EVEESEALVLERDGPRCRLVLPAAQ 1052
              ++ SE + +E       LV+   Q
Sbjct: 24171 LLQNSENITIENTEHYTHLVMKNVQ 24195



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 44/168 (26%), Positives = 71/168 (42%), Gaps = 14/168 (8%)

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTG-EWARGG----VQLYPGPKCHIHSDGHRHRLVL 1598
            +PL+ V + EG +ATF+  +S   V    W R G        PG +    SDG R +L +
Sbjct: 10   QPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDG-RAKLTI 67

Query: 1599 NGLGLADSGCVSFTADS----LRCAARLIVR--EVPVTIVRGPHDLEVTEGDTATFECEL 1652
              +  A+SG  S  A +        A L+V+    P   V+    + V +G     +  +
Sbjct: 68   PAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRV 127

Query: 1653 SQALADVT-WEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYS 1699
            +     V  + +DG  +  S   ++   G    L +    P D+GTYS
Sbjct: 128  TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 61/249 (24%), Positives = 93/249 (37%), Gaps = 58/249 (23%)

Query: 1614 DSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSP 1672
            ++ R  A + +   P T+V G  ++ V EG++ T EC +S      VTW ++   +  S 
Sbjct: 882  ETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI 941

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTAR-----AGPVRLTVRERTVAV-- 1721
              ++        L +R     D+G ++C+     GT       A  V     + T AV  
Sbjct: 942  DFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001

Query: 1722 ---LSELRSVSAR----------------------------------EGDGATFECTV-S 1743
                 E R V +R                                  EG    F C V  
Sbjct: 1002 KFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGG 1061

Query: 1744 EVETTGRWELGGRPLRPGARVRI---RQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
              +    W+  G PL  G R ++   +Q G+   LV+S   A+DAGE    VR + G   
Sbjct: 1062 NPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECK-LVISMTFADDAGEYTIVVRNKHGETS 1120

Query: 1797 SLALLEVEA 1805
            + A L  EA
Sbjct: 1121 ASASLLEEA 1129



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 35/144 (24%), Positives = 63/144 (43%), Gaps = 7/144 (4%)

Query: 232   SPPADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
             S P  P ++  P+  P  K   +   V    +A   C V G P+P ++W+ +G+ ++ D 
Sbjct: 24417 SEPITP-KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 24475

Query: 291   RRLMYRDRDGGF-VLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP-RLRFTRPLQ 348
              +   ++  GG+  L +      D  +Y   A N  G       L V+ P ++   + L+
Sbjct: 24476 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLE 24535

Query: 349   DVEGREHGI--AVLECKVPNSRIP 370
              + G  H +   V+  K+P S  P
Sbjct: 24536 GM-GAVHALRGEVVSIKIPFSGKP 24558



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 2/97 (2%)

Query: 19    RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
             R   +  G    L  ++ G P P V W+K  +      R+     G++  L +  A   D
Sbjct: 10729 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK--LEIRNAAHED 10786

Query: 79    AGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
              G+Y     N AG    +  V VL+ P    +L+ +E
Sbjct: 10787 GGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSE 10823



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 75/311 (24%), Positives = 119/311 (38%), Gaps = 33/311 (10%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PGPP + E+ K  KN++ + W  P     +    Y LE+++  S  W +    E      
Sbjct: 20569 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLK-ETIRDTR 20627

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPH---VVFHGSAHLV----PTARL---------VA 620
                  +    DY++R+C V+  G+ P      F+ +A  +    P A++         + 
Sbjct: 20628 QKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT 20687

Query: 621   GLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHR 680
                   VYDG  AV    +  I QG      EE  +   +G+V          + G+ + 
Sbjct: 20688 LGWSKPVYDGGSAVTGY-VVEIRQG----EEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 20742

Query: 681   LILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERV-VLTCE 739
               + AV     G  +  + P VQ   A  I E+P   L    R S+     E V VL   
Sbjct: 20743 FRVSAVNCAGQGEPIEMNEP-VQ---AKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPF 20798

Query: 740   LSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE-GV----S 794
               R     TW KD + +       ++       L +P+    D+G++    E GV    S
Sbjct: 20799 KGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKS 20858

Query: 795   AFFGVTVQDPP 805
             +   V V D P
Sbjct: 20859 STVSVKVLDTP 20869



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 5/103 (4%)

Query: 492  AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI- 550
            A E  + +G     + +  K  +  PPGPP   E     K+ V LTW  P+    +P   
Sbjct: 7361 AAENMYGVGEPVQASPITAK-YQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITG 7419

Query: 551  YRLERQEVGSEDWIQCFSIE-KAGAVEVPGDCVPSEGDYRFRI 592
            Y +ER +  ++ W++C  +  K     V G  + ++  YRFR+
Sbjct: 7420 YWVERLDPDTDKWVRCNKMPVKDTTYRVKG--LTNKKKYRFRV 7460



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 34/164 (20%), Positives = 71/164 (43%), Gaps = 17/164 (10%)

Query: 823   ECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA 881
             E   L+C++     P ++WY+ G+E+ +S    + ++G    L +   +  D G + C+A
Sbjct: 24051 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24110

Query: 882   GDECAYFTVTITDVSSWIV----------YPSGKVYVAAVRLERVVLTCELCRPWAEVRW 931
              +E     V   + SS ++          YP  + Y  AV     +    + RP   + W
Sbjct: 24111 TNE-----VGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW 24165

Query: 932   TKDGEEVVESPALLLQKEDTVRRLVLPAVQLE-DSGEYLCEIDD 974
                 + +  S  + ++  +    LV+  VQ +  +G+Y  ++ +
Sbjct: 24166 FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSN 24209



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 516  SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
            SPPGPPI   +      T+ L W+PP        + Y +++Q VG+ +W +C   EK   
Sbjct: 8504 SPPGPPI-PRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRC--TEKMIK 8560

Query: 575  VEVPGDCVPSEG-DYRFRICTVSGHGRSP 602
            V         EG DY+ R+  V+  G  P
Sbjct: 8561 VRQYTVKEIREGADYKLRVSAVNAAGEGP 8589



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 32/91 (35%), Positives = 43/91 (47%), Gaps = 7/91 (7%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPE---PAPETPFIYR-LERQEVGS--EDWIQCFSIE 570
            PP PPI  ++    KNTV L+WKPP+    +P T +I   L     G+  E W QC   +
Sbjct: 9514 PPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRD 9573

Query: 571  KAGAVEVPGDCVPSEGDYRFRICTVSGHGRS 601
                     D V   G+Y FR+  V+  G S
Sbjct: 9574 VEELQFTVEDLVEG-GEYEFRVKAVNAAGVS 9603



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 43/144 (29%), Positives = 52/144 (36%), Gaps = 17/144 (11%)

Query: 93    AYAAAAVTVLEPPA-SDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRA 151
             A A  AV +  P   SDP    AE   P           LT      V  G  V L    
Sbjct: 12769 AIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLT------VKAGTNVCLDATV 12822

Query: 152   GGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHA 211
              G P PT+ W+KDG  L    +    A+Q             L + +    DSG Y   A
Sbjct: 12823 FGKPMPTVSWKKDGTLLKPA-EGIKMAMQRNLC--------TLELFSVNRKDSGDYTITA 12873

Query: 212   RNAHGHAQAGALLQVHQPPESPPA 235
              N+ G   A   L+V   P  PPA
Sbjct: 12874 ENSSGSKSATIKLKVLDKP-GPPA 12896



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 8/109 (7%)

Query: 235   ADPDEAPAPVVEPLKCAP-------KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
             +DP +   PV+      P        TF V  G+  K     +G+P P + WH +  P L
Sbjct: 15633 SDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVP-L 15691

Query: 288   PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
                 R+     +   +L +     +D G YV    NSAG+ +  + + V
Sbjct: 15692 KQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15740



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 3/100 (3%)

Query: 15    LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
             ++F   + V +G   ++   + G P PV+ W K G ++    R    +      L +   
Sbjct: 19296 VKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDC 19355

Query: 75    LPTDAGVYVCRARNAAGEAYAAAAVTVLE---PPASDPEL 111
             +  D G YV   +N AG    A    VL+   PPA   E+
Sbjct: 19356 IRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEI 19395



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 11/112 (9%)

Query: 460   RWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
             +W+ DG E+         +      L +    R D GE   ++ N+  +  + V      
Sbjct: 11046 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLD 11105

Query: 517   PPGPPI----LAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
              PGPP     + ++   H   + ++W+PP+    +P I Y +E+Q+   + W
Sbjct: 11106 VPGPPTGPINILDVTPEH---MTISWQPPKDDGGSPVINYIVEKQDTRKDTW 11154



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 3/122 (2%)

Query: 479   MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW 538
             M  LV+P  TR+D+G+ + +L N      + V       PGP    ++    K +  ++W
Sbjct: 12163 MAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSW 12222

Query: 539   KPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
              PPE    +    Y +E++E   + W       K  +  V  + VP   +Y FR+  V+ 
Sbjct: 12223 APPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVT-NLVPG-NEYYFRVTAVNE 12280

Query: 598   HG 599
             +G
Sbjct: 12281 YG 12282



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 108/521 (20%), Positives = 190/521 (36%), Gaps = 75/521 (14%)

Query: 475   SSGHMHALVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCVKHSPPGPPILAEMFKGH 530
             SS     L++    + DAG+ T +L    G    T  ++V      P GP    E+    
Sbjct: 13536 SSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTA-- 13593

Query: 531   KNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEG-DY 588
                + L W PP+    +    Y LE+++  +  W+ C S  +     V       EG +Y
Sbjct: 13594 -EAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTR---LHEGMEY 13649

Query: 589   RFRICTVS----GHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
              FR+   +    G G     +       VP A     + DV+ +D     ++    T   
Sbjct: 13650 TFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVR-HDSVSLTWTDPKKT--- 13705

Query: 645   GTWFLNGEELKSNEPEGQVEPGALRYRIEQK---------GLQHRLILHAVKHQDSGALV 695
             G   + G  L+  E    +   A +  I  +         GL++   + A+       L 
Sbjct: 13706 GGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAIN------LA 13759

Query: 696   GFSCPGVQDSAALTIQE-----SPVHILSPQDRVSLTFTTSE----RVVLTCELSRVDFP 746
             G   P +     + +        P  I   ++ V+L +T  +      +    + + D P
Sbjct: 13760 GVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLP 13819

Query: 747   A-TWYKDGQ-KVEESELLVVKM-DGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQD 803
             + +W K     V E    V  + +G K+   +  AK   +G     +E           +
Sbjct: 13820 SKSWMKANHVNVPECAFTVTDLVEGGKYEFRI-RAK-NTAGAISAPSESTETIICKDEYE 13877

Query: 804   PPVHIVDPREHVFVHAITSECVML-ACEVDREDAPVR-WYKDGQEVEESDFVVLENEGPH 861
              P  ++DP     +     + ++L A  +  +  P   W K G+++  SD   + +    
Sbjct: 13878 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 13937

Query: 862   RRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVV 917
               L +      D GE+   A    G +  +  VT+ DV      P G V ++ V  E+  
Sbjct: 13938 SMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPG----PPGPVEISNVSAEKAT 13993

Query: 918   LTCELCRPWAEVRWT---KDGEEVVESPALLLQKEDTVRRL 955
             LT           WT   +DG   ++S   +L+K +T R L
Sbjct: 13994 LT-----------WTPPLEDGGSPIKS--YILEKRETSRLL 14021



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 43/170 (25%), Positives = 66/170 (38%), Gaps = 14/170 (8%)

Query: 253   KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP--DRRRLMYRDRDGGFVLKVLYCQ 310
             KT +V  G++ +F   +   PEP + W+  G+ + P  + ++  +    G + L +    
Sbjct: 25202 KTAYV--GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVT 25259

Query: 311   AKDRGLYVCAARNSAGQTLSAVQLHV--------KEPRLRFTRPLQDVEGREHGIAVLEC 362
               D   Y   ARN  G+     +L V           R  F R L + E +E      E 
Sbjct: 25260 TDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEI 25319

Query: 363   KVPNSRIPT-AWFREDQRLLPCRKYEQIEEG-TVRRLIIHRLKADDDGIY 410
             +V     PT  W ++ Q L      E I EG     L I     +D G Y
Sbjct: 25320 RVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYY 25369



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 12/128 (9%)

Query: 119  PSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAG----------GLPEPTLYWEKDGMAL 168
            PS  +GE     +      ++  GA+  L C+AG          G P P   WE DG A 
Sbjct: 9295 PSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAK 9354

Query: 169  DEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ 228
              + D  H   +  + E    +S+ + I   +   +G Y   A+N  G   A   ++V  
Sbjct: 9355 KAMKDGVHDIPEDAQLETAENSSVII-IPECKRSHTGKYSITAKNKAGQKTANCRVKVMD 9413

Query: 229  PPESPPAD 236
             P  PP D
Sbjct: 9414 VP-GPPKD 9420



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 27/131 (20%)

Query: 124   GEGAPVFLTGP----------------RSQWVLR-GAEVVLTCRAGGLPEPTLYWEKDGM 166
             G+G P F T P                R +  +R G    LT R  G P+P + W KD  
Sbjct: 10301 GQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEA 10360

Query: 167   ALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
              + E  D +H    P        A+LAL  + A+  DSG Y     N+ G  +    + V
Sbjct: 10361 DVLED-DRTHIKTTP--------ATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNV 10411

Query: 227   HQPPESPPADP 237
                P  PP  P
Sbjct: 10412 VDRP-GPPVGP 10421



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 2/86 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC-FSIEKAGAV 575
             P PP+  E      N+V LTW+PP     +  + Y +E Q+VG E+W +   + E     
Sbjct: 10616 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 10675

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             +     +     Y+FR+  V+  G S
Sbjct: 10676 KYKVTGLRDGQTYKFRVLAVNAAGES 10701



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 43/154 (27%), Positives = 67/154 (43%), Gaps = 19/154 (12%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP         K  V L W  P+    +P   Y +E QE G++DWI+  ++     V
Sbjct: 10912 PPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECV 10971

Query: 576   EVPGDCVPSEGDYRFRIC--TVSGHGRSPHVV-FHGSAHLVPTARLVAGLEDVQVYDG-- 630
              V G  +     YRFR+    + G G     +       LVP +  +    DV++ +G  
Sbjct: 10972 -VTG--LQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVEL----DVKLIEGLV 11024

Query: 631   EDAVFSLDLSTIIQGT------WFLNGEELKSNE 658
               A  ++    II+G       W  +G E+K++E
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDE 11058



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 4/113 (3%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILA-EMFKGHKNTVLLTWK- 539
             L++  VTR+D+G  + +  NS  T   ++K V    PGPP    ++     +   L+W  
Sbjct: 12459 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHI 12518

Query: 540   PPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
             P E        Y +E+ +V   DW+   +     +  V G  +P + +Y FR+
Sbjct: 12519 PLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRV-GKLIPGQ-EYIFRV 12569



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 42/163 (25%), Positives = 63/163 (38%), Gaps = 22/163 (13%)

Query: 453   LEAGVEGR------WSRDGEELPVICQ----SSSGHMHALVLPGVTREDAGEVTFSLGNS 502
             LEA + G+      WS+DG+EL          S+     LV+    R D G+    L N 
Sbjct: 18230 LEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV 18289

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKPP-EPAPETPFIYRLERQEVGS 560
               T  + +       PGPP       G       L W PP +        Y +E++E   
Sbjct: 18290 GGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSR 18349

Query: 561   EDWIQCFSIEKAGAVEV----PGDCVPSEGDYRFRICTVSGHG 599
               W Q  +  +A   +V    PG+      +Y FR+  V+ +G
Sbjct: 18350 LSWTQVSTEVQALNYKVTKLLPGN------EYIFRVMAVNKYG 18386



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 39/171 (22%), Positives = 71/171 (41%), Gaps = 12/171 (7%)

Query: 1005  ECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC-- 1061
             E   L C++     P ++WY+ G E+ +S    +  DG    L +   + ED G + C  
Sbjct: 24051 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24110

Query: 1062  --DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQV---RWYK 1116
               + G+      + + A P+   HP     + ++GA G   LR  V   G  V    W+ 
Sbjct: 24111 TNEVGEVETSSKLLLQATPQ--FHPGYPLKEKYYGAVGST-LRLHVMYIGRPVPAMTWFH 24167

Query: 1117  DGLEVEASDALQLGAEGPTRTLTLPHAQPE-DAGEYVCETRHEAITFNVIL 1166
                 ++ S+ + +        L + + Q +  AG+Y  +  +   T + IL
Sbjct: 24168 GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAIL 24218



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 6/112 (5%)

Query: 231 ESPPADPDEAPAPVVEP-----LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
           E+   +    PAPV  P     L    K   V EG+     C++ G P P + W+ E   
Sbjct: 877 EAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 936

Query: 286 LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
            +          + G   L +    A+D G + C+A N AG   ++  L V+
Sbjct: 937 -IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 30/120 (25%), Positives = 52/120 (43%), Gaps = 4/120 (3%)

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKP 540
            LV+P   R D G  T +  N+  T    ++      PGPP+    F+    + + L+W P
Sbjct: 9684 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFP 9743

Query: 541  PEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
            P+    +    Y +E++E   + W+   S  K     +P   +    +Y FRI   + +G
Sbjct: 9744 PKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPK--LLEGHEYVFRIMAQNKYG 9801



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 3/91 (3%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFS 568
             C    PPGPPI  ++    + T  L W  P     +P + Y +E Q+ G+  W  I    
Sbjct: 11301 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11360

Query: 569   IEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
             + +  A  VPG    +E  +R +   + G G
Sbjct: 11361 LIRQCAFRVPGLIEGNEYRFRIKAANIVGEG 11391



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 71/336 (21%), Positives = 122/336 (36%), Gaps = 30/336 (8%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P  P  A + K +K+ + + W  P+    +P I Y +ER+E  S  W++  +     + E
Sbjct: 12595 PSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKA-NDTLVRSTE 12653

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSP------------HVVFHGSAHLVPTARLVAGLED 624
              P   +    +Y FRI  ++  G SP             V   G   ++   +    L  
Sbjct: 12654 YPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIW 12713

Query: 625   VQ-VYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLI 682
              +  +DG   +    +    + G  ++         P+ +     L    E+   Q R I
Sbjct: 12714 ARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLE---EKAQYQFRAI 12770

Query: 683   LHAVKHQDSGALVGFSCPG-VQDSAALTIQESPVHI-LSPQDRVSLTFTTSERVVLTCEL 740
                         V  S P    D   +  +  P  I LS   +  LT      V L   +
Sbjct: 12771 ARTA--------VNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 12822

Query: 741   SRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGV 799
                  P  +W KDG  ++ +E + + M      L L     +DSG++    E  S     
Sbjct: 12823 FGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSA 12882

Query: 800   TVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
             T++   +    P   V ++ + S+  ML+ E   ED
Sbjct: 12883 TIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLED 12918



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 22/71 (30%), Positives = 30/71 (42%)

Query: 35    VLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAY 94
             +LG+P P   W K G+ +  S+     +      L +  A   DAG Y   A N  G   
Sbjct: 13906 ILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKV 13965

Query: 95    AAAAVTVLEPP 105
                 VTVL+ P
Sbjct: 13966 EHVKVTVLDVP 13976



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query: 481   ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKP 540
             +L +    R D+G+ T ++ N  +   L +       PGPP    +    K + +L+W  
Sbjct: 19744 SLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDV 19803

Query: 541   PEPAPETPF-IYRLERQEVGSEDWI 564
             PE     P   Y +E++E   + W+
Sbjct: 19804 PENDGGAPVKNYHIEKREASKKAWV 19828



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 27/114 (23%), Positives = 51/114 (44%), Gaps = 7/114 (6%)

Query: 238   DEAPAPVVEPLKCAPKTF---WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLM 294
             DE   P+VE     P+ F    +  G+  + +  V G+P P + W  +G   +  R  + 
Sbjct: 21454 DENVPPIVE---FGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVE-IEKRMNME 21509

Query: 295   YRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQ 348
               D  G   L V       RG+Y   A+N++G   + +++ V++   +   P++
Sbjct: 21510 ITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIR 21563



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 50/248 (20%), Positives = 90/248 (36%), Gaps = 25/248 (10%)

Query: 1384  SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGT----VTLRAGSTATS 1439
             S P A+V W  NG  +    ++          L +  C   D+GT     T   G  +  
Sbjct: 25902 SKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDY 25961

Query: 1440  ARLHV-----------RETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQ 1488
             A L V           R  E +      ++   E   V    +T  + A+ +VR V+   
Sbjct: 25962 ATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQM 26021

Query: 1489  PLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLED 1548
                 ++R S++   H     +    L +      +S  +++  R        R+L     
Sbjct: 26022 T---ETRESLSSYEHSASAEMKSAALEE------KSLEEKSTTRKIKTTLAARILTKPRS 26072

Query: 1549  VTISEGGSATFQLELSQEGV-TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG 1607
             +T+ EG SA F  +   E V T  W R G  L    +  + +  ++    ++ +  +D G
Sbjct: 26073 MTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEG 26132

Query: 1608  CVSFTADS 1615
               S   ++
Sbjct: 26133 NYSVVVEN 26140



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 26/108 (24%), Positives = 39/108 (36%), Gaps = 1/108 (0%)

Query: 229   PPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
             P E      D+  AP ++        +   E  + + +  + GKP P + W     PL  
Sbjct: 13469 PSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLAT 13528

Query: 289   DRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
             D  R+          L V  CQ  D G Y    +N AG     + + V
Sbjct: 13529 D-TRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 13575



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 61/268 (22%), Positives = 96/268 (35%), Gaps = 52/268 (19%)

Query: 312   KDRGLYVCAARNSAGQTLSAVQ----LHVKEPRLRF---TRPLQDVEGREHGIAVLECKV 364
             KD  + V AAR S G  + + +      VK   +     +  +    G E G     CK+
Sbjct: 25035 KDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYVCKI 25094

Query: 365   PNSRIPT--AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM---RGRVR 419
              N    T   W+   ++L    KYE   E  V  L +  +   DDG Y C++    G   
Sbjct: 25095 ENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 25154

Query: 420   TVANVTVKG----------PILKRLPRKLDVLE-------------------GENAVLLV 450
             + A + VKG            +K++ R+ D +                    GEN    V
Sbjct: 25155 SYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGV 25214

Query: 451   E-TLEAGVEGRWSRDGEEL-------PVICQSSSGHMHALVLPGVTREDAGEVTFSLGN- 501
               T+       W + G+++           +S  G ++ L +  VT +D  E T    N 
Sbjct: 25215 TITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKG-LYQLTINSVTTDDDAEYTVVARNK 25273

Query: 502   -SRTTTLLRVKCVKHSPPGPPILAEMFK 528
                 +   ++    H PP    L  MFK
Sbjct: 25274 YGEDSCKAKLTVTLHPPPTDSTLRPMFK 25301



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 5/116 (4%)

Query: 223   LLQVHQPPESPP---ADPDEAPAPVVEP-LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIE 278
             ++ V++   S P   A P  A   V+EP +K A  ++ V  G+  K    + G+P+P I 
Sbjct: 16706 VVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTIT 16765

Query: 279   WHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
             W  +G P L    R+   D      L +      D G Y     N  GQ  +++++
Sbjct: 16766 WTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEI 16820



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 1284  GGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCD 1342
             G DL++ + + G   P + W KDGE L    RV +E+     VL ++     D G+Y   
Sbjct: 17829 GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVT 17888

Query: 1343  A 1343
             A
Sbjct: 17889 A 17889



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V+ G   +   YV GKP P + W+   R  LP    +         V+K   CQ   +G+
Sbjct: 10039 VHAGGVIRIIAYVSGKPPPTVTWNMNER-TLPQEATIETTAISSSMVIK--NCQRSHQGV 10095

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y   A+N AG+    + + V
Sbjct: 10096 YSLLAKNEAGERKKTIIVDV 10115



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 23/80 (28%), Positives = 32/80 (40%), Gaps = 1/80 (1%)

Query: 257   VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
             V  G   +F   + G P P  +W  +G  +  D    +  D     VL +  C  +D G 
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS-VLTIKNCLRRDTGE 11083

Query: 317   YVCAARNSAGQTLSAVQLHV 336
             Y     N+AG    AV L V
Sbjct: 11084 YQITVSNAAGSKTVAVHLTV 11103



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 1/68 (1%)

Query: 1274  AAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
             A +T V +  G D+++++   G P   V W KD + L S  R  +E   +  +L +    
Sbjct: 20779 ALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVT 20838

Query: 1333  SGDAGEYL 1340
               D G+Y+
Sbjct: 20839 RNDTGKYI 20846



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 1/50 (2%)

Query: 518  PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
            P PP+        +++V L W+PP     +P + Y +ER E G ++WI+C
Sbjct: 6795 PSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 6844



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 4/92 (4%)

Query: 516   SPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGA 574
             +PPG P    +    + +V L W  PE    +    Y +E Q+V   +W +C +      
Sbjct: 23534 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKC-NTTPTKI 23592

Query: 575   VEVPGDCVPSEGDYRFRI--CTVSGHGRSPHV 604
              E     +P   +YRFR+  C   G G    V
Sbjct: 23593 REYTLTHLPQGAEYRFRVLACNAGGPGEPAEV 23624



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)

Query: 19   RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
            + V V    +A  +CV+  E    V+W KG   + +S++    ADG +H L++  +   D
Sbjct: 4996 KDVTVPERRQARFECVLTREAN--VIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDD 5053

Query: 79   AGVY 82
             GVY
Sbjct: 5054 EGVY 5057



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 3/106 (2%)

Query: 231  ESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
            E    D  EAP   ++    A  T  V  G   +    V GKPEP+I W  +   +L   
Sbjct: 7181 EIQAVDTQEAPEIFLDVKLLAGLT--VKAGTKIELPATVTGKPEPKITW-TKADMILKQD 7237

Query: 291  RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            +R+   +      + ++  +  D G Y+  A N  G+  + V+++V
Sbjct: 7238 KRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7283



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 17/49 (34%), Positives = 29/49 (59%), Gaps = 1/49 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQ 565
             PGPP   ++F   ++ + LTW PPE    +    Y +ER+EV ++ W++
Sbjct: 23435 PGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVR 23483



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 6/88 (6%)

Query: 1725  LRSVSAREGDGATFECTVSEVET-TGRWELGGRPLRPGARVRIRQEG-KKHILVLSELRA 1782
             L +   +EG    FE  VS +   T +WE  G+PL  G  + I  EG   + L + +   
Sbjct: 25304 LANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLP 25363

Query: 1783  EDAGEVRF----QAGPAQSLALLEVEAL 1806
             ED G  R      AG     A L+VE L
Sbjct: 25364 EDTGYYRVTATNTAGSTSCQAHLQVERL 25391



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 518  PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW--IQCFSIEKAGA 574
            PGPP   ++    K ++L++W PP     +P   Y LE++E GS  W  +    I K G 
Sbjct: 9102 PGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGL 9161

Query: 575  VEVPGDCVPS--EG-DYRFRICTVSGHGRSP 602
              V  + VP   EG  Y+FR   ++  G  P
Sbjct: 9162 KGVEFN-VPRLLEGVKYQFRAMAINAAGIGP 9191



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 129/621 (20%), Positives = 223/621 (35%), Gaps = 84/621 (13%)

Query: 517   PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PP PP    +    + +  L W+ PE    +  + Y +E Q  G+E W      +   AV
Sbjct: 17715 PPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAV 17774

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS-PHV----VFHGSAHLVPTARLVAGLEDVQVYDG 630
              V G  + S  +Y+FR+   +  G+S P V    V      + P+ +L      +Q   G
Sbjct: 17775 -VTG--LSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQA--G 17829

Query: 631   EDAVFSLDLSTIIQG----TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAV 686
             ED    +++  I +     +W  +GE LK             R  +E+      L +   
Sbjct: 17830 ED--LKIEIPVIGRPRPNISWVKDGEPLKQ----------TTRVNVEETATSTVLHIKEG 17877

Query: 687   KHQDSG---ALVGFSCPGVQDSAALTIQESPVHILSPQ--DRVSLTFT--TSERVVLT-- 737
                D G        S     ++ ++ + E P   + P   D VS  F   + E    T  
Sbjct: 17878 NKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGG 17937

Query: 738   CELS------RVDFPATWYKDGQKVEESELLVVKM-DGRKHRL-ILPEAKVQDSGEFECR 789
             C++S      R     TW+     V  + + + K+  G +++  I  E +   S   + +
Sbjct: 17938 CQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSK 17997

Query: 790   TEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR--WYKDGQEV 847
                        +   P     P    FV +I+ + +++       D   +   Y   Q+ 
Sbjct: 17998 ---------AVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKE 18048

Query: 848   EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY-----P 902
             + S   V  N+ P +      T   +G E++     E        + VS   V      P
Sbjct: 18049 KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP 18108

Query: 903   SGKVYVAAVRLERVVLT---------CELCRPWAEVRWTKDGEEVVESPALLLQKEDTVR 953
              G+     +    V L           ++     E +   DG  +  S   +L+ E TV 
Sbjct: 18109 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 18168

Query: 954   RLV------LPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECV 1007
              LV         +    +G +    D   A       + P   + P+ +  ++    E  
Sbjct: 18169 GLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETF 18228

Query: 1008  VLMCELSREDAP-VRWYKDGLEVEESEA-LVLERDGPRCRLVLPAAQPEDGGEFVCD--- 1062
             VL  ++  +  P V W KDG E+EE+ A + ++    +  LV+      DGG+++     
Sbjct: 18229 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 18288

Query: 1063  -AGDDSAFFTVTV---TAPPE 1079
               G  S   TV V     PPE
Sbjct: 18289 VGGTKSIPITVKVLDRPGPPE 18309



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 30/146 (20%), Positives = 63/146 (43%), Gaps = 7/146 (4%)

Query: 461   WSRDGEELPVICQ---SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP 517
             W +DGE L    +     +     L +    ++D G+ T +  NS  T    +  +    
Sbjct: 17848 WVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 17907

Query: 518   PGPPILAEMF-KGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAV 575
             PGPP+    F +   + V+++W+PP          Y +E+++  +  W    +      +
Sbjct: 17908 PGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTI 17967

Query: 576   EVPGDCVPSEGDYRFRICTVSGHGRS 601
             ++    + +  +Y+FRI   + +G+S
Sbjct: 17968 KITK--LKTGTEYQFRIFAENRYGKS 17991



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 190/979 (19%), Positives = 339/979 (34%), Gaps = 168/979 (17%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQ---EVGSEDWIQC-FSIEKA 572
             PG P + ++ +   +TV L W  P     +  + Y +ER+   EVG   W++C ++I   
Sbjct: 22445 PGRPEVTDVTR---STVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSD 22501

Query: 573   GAVEVPGDCVPSEGD-YRFRICTVSGHG------RSPHVVFHGSAHLVPTARLVAGLED- 624
                 V      SEGD Y FR+   +  G       S   V     +  P A L A L   
Sbjct: 22502 NFFTVTA---LSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGD 22558

Query: 625   -VQVYDGEDAVFSLDLSTIIQGT------WFLNGEELKSNEPEGQVEPGALRYRIEQKGL 677
              V +  G D V    L   + G       W    +EL   E          +  ++  G 
Sbjct: 22559 LVTIRAGSDLV----LDAAVGGKPEPKIIWTKGDKELDLCE----------KVSLQYTGK 22604

Query: 678   QHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLT 737
             +   ++      DSG     +      + A+++    +    P  +++++  T E+  L 
Sbjct: 22605 RATAVIKFCDRSDSGKYT-LTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLA 22663

Query: 738   CELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF 796
               L + D  A   +   ++ E S L  V ++G    L     ++  + E+  R   V+ +
Sbjct: 22664 WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKY 22723

Query: 797   F-GVTVQDPPV----------------HIVDPREHVFVHAITSEC-----VMLACEVDRE 834
               GV V+  P+                 +   +EH+ +     E      +       RE
Sbjct: 22724 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKRE 22783

Query: 835   DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITD 894
                +RW +  +     D+VV +         L  T   +G ++Q       A      ++
Sbjct: 22784 KKSLRWTRVNK-----DYVVYDTR-------LKVTSLMEGCDYQFRVTAVNAAGNSEPSE 22831

Query: 895   VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTK---DGEEVVESPALLLQKEDT 951
              S++I               RVV T +       + WTK   DG   +    L +Q++DT
Sbjct: 22832 ASNFISCREPSYTPGPPSAPRVVDTTKHS---ISLAWTKPMYDGGTDIVGYVLEMQEKDT 22888

Query: 952   -----------VRRLVLPAVQLEDSGEYLCEIDDESA------SFTVTVTEPPVRIIYPR 994
                        +R        L+   +Y   +   +       S ++   EP  RI  P 
Sbjct: 22889 DQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPD 22948

Query: 995   DEVT---LIAVTLEC---VVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLV 1047
              E+       VT+     + LM  +S    PV  W K G+++  +   +++       L+
Sbjct: 22949 LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDL--ASRAIIDTTESYSLLI 23006

Query: 1048  LPAAQPEDGGEFVCDAGDDSAFFTVTVTA---------PPERIVHPAARSLDLHFGAP-- 1096
             +      D G++  +A + S   + TV           P  ++   +  S+ + +  P  
Sbjct: 23007 VDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 23066

Query: 1097  --GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDA---GEY 1151
               G       V    + +R +K  +  + S  L   +     T+      PE+    GE 
Sbjct: 23067 DGGAPVNNYIVEKREAAMRAFKT-VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE- 23124

Query: 1152  VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVV--------LSCELSRAGA- 1202
              CET    +   V L   P +   ++ T S + +A  +P+            E  +AG  
Sbjct: 23125 PCETSDAVLVSEVPLV--PAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTE 23182

Query: 1203  ---------PVVWSHNGRPVQEGEG--LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAP 1251
                      P V  H    + EGE     + A+  + V                   + P
Sbjct: 23183 RWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGV-------------------SEP 23223

Query: 1252  GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA 1310
                  + TVQ       +      Q  +    G  +ELV+ ++G P     W+  G +L 
Sbjct: 23224 RETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLR 23283

Query: 1311  SQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLT 1370
                RV +E       L ++     D GEY  +    +     +++  +L K      P+ 
Sbjct: 23284 ESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIK 23343

Query: 1371  VHEGDDATFRCEVSPPDAD 1389
             + E D  +      PP+ D
Sbjct: 23344 IDEIDATSITISWEPPELD 23362



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 50/188 (26%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 705 SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVV 764
           SA  + Q+    + +P  + S T   +E   L  +    D P T YK    VE  + + V
Sbjct: 801 SATSSAQKITKSVKAPTVKPSETRVRAEPTPLP-QFPFADTPDT-YKSEAGVEVKKEVGV 858

Query: 765 KMDG---RKHRLIL---PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
            + G   R+ R  +    EAKV ++       E         +   P  +V   ++V V 
Sbjct: 859 SITGTTVREERFEVLHGREAKVTETARVPAPVE---------IPVTPPTLVSGLKNVTV- 908

Query: 819 AITSECVMLACEVDREDAP-VRWYKDGQEVEES-DFVVLENEGPHRRLVLPATQPSDGGE 876
            I  E V L C +    +P V WY++  ++E S DF +    G   RL++      D G 
Sbjct: 909 -IEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG-IARLMIREAFAEDSGR 966

Query: 877 FQCVAGDE 884
           F C A +E
Sbjct: 967 FTCSAVNE 974



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 3/92 (3%)

Query: 332 VQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIE 390
           V++ V  P L     L++V   E     LEC +     PT  W+RED ++     ++   
Sbjct: 890 VEIPVTPPTL--VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947

Query: 391 EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
           +  + RL+I    A+D G + C       TV+
Sbjct: 948 QSGIARLMIREAFAEDSGRFTCSAVNEAGTVS 979



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 33/111 (29%), Positives = 46/111 (41%), Gaps = 7/111 (6%)

Query: 229  PPESPP---ADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
            P E+ P   A+P E PA  VE          +  GK  +    V G+P P   W  E   
Sbjct: 8590 PGETQPVTVAEPQEPPA--VELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGE 8647

Query: 286  LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            L  D+ R++  +      L +     KD G YV  A NS G   +A ++ V
Sbjct: 8648 L--DKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV 8696



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 23/83 (27%), Positives = 35/83 (42%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +G    +   V G+PPP V W    + L     +   A  +   +++     +  GVY
Sbjct: 10039 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSS--MVIKNCQRSHQGVY 10096

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                A+N AGE      V VL+ P
Sbjct: 10097 SLLAKNEAGERKKTIIVDVLDVP 10119



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 21/90 (23%), Positives = 36/90 (40%), Gaps = 2/90 (2%)

Query: 26    GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
             G + +++  + G P P + W K G  L  + R++         L +      D G Y   
Sbjct: 16747 GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGIT 16806

Query: 86    ARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
               N  G+  A+  +  L+ P  DP   P +
Sbjct: 16807 VANVVGQKTASIEIVTLDKP--DPPKGPVK 16834



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 93/414 (22%), Positives = 145/414 (35%), Gaps = 55/414 (13%)

Query: 226   VHQPPES--PPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             + +P +S  P    DE   P +        T  VN G+  +    V GKP P IEW   G
Sbjct: 17107 ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW-LRG 17165

Query: 284   RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV------- 336
                + +  R   ++ D   +L V      D G Y+  A N AG     V + V       
Sbjct: 17166 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17225

Query: 337   -----------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW-FREDQRLLPCR 384
                        ++  L ++ PLQD  G +    V+E K   SR+  AW     + +    
Sbjct: 17226 EGPVQVTGVTSEKCSLTWSPPLQD-GGSDISHYVVE-KRETSRL--AWTVVASEVVTNSL 17281

Query: 385   KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP-ILKRLPRKLDVLEG 443
             K  ++ EG     +   +  +  G+      G     A V +K P +L   P+ L+V   
Sbjct: 17282 KVTKLLEG--NEYVFRIMAVNKYGV------GEPLESAPVLMKNPFVLPGPPKSLEVTNI 17333

Query: 444   ENAVLLV-----------ETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDA 492
                 + V           E +   VE R  R G    + C         L + G+T +  
Sbjct: 17334 AKDSMTVCWNRPDSDGGSEIIGYIVEKR-DRSGIRW-IKCNKRRITDLRLRVTGLTEDHE 17391

Query: 493   GEVTFS------LGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTW-KPPEPAP 545
              E   S      +G     T+    C     PGPP  A +    KN++ L W KP     
Sbjct: 17392 YEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGG 17451

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
                  Y +E  +   E+W                  +    +Y+ R+C ++  G
Sbjct: 17452 SEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVG 17505



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
             V + DAG+   +L NS       +       PGPP+   + +  K++  +TW+PP     
Sbjct: 13259 VNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGG 13318

Query: 547   TPFI-YRLERQEVGSEDW 563
             +P I Y +++++   + W
Sbjct: 13319 SPIINYVVQKRDAERKSW 13336



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 4/91 (4%)

Query: 514   KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKA 572
             +  PPGPP   E+    KNT  ++WK P     +    Y +ER+E  S  W++      +
Sbjct: 14071 RFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVS 14130

Query: 573   G-AVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
                 +V G  +     Y FR+   +  G  P
Sbjct: 14131 DLRCKVTG--LQEGSTYEFRVSAENRAGIGP 14159



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 1/82 (1%)

Query: 461   WSRDGEELPVICQSSSGHMHA-LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
             WSR+  E     Q   G  +  L +    R DAG+    L NS  +    V       PG
Sbjct: 17561 WSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPG 17620

Query: 520   PPILAEMFKGHKNTVLLTWKPP 541
             PP    + +  K++  L W+PP
Sbjct: 17621 PPQNLAVKEVRKDSAFLVWEPP 17642



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 18/64 (28%), Positives = 28/64 (43%), Gaps = 3/64 (4%)

Query: 1657  ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAG---PVRLT 1713
             A V W KDG  L  + R+ + +  T   L ++     D GTY   V  +      P+ + 
Sbjct: 18927 ATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITII 18986

Query: 1714  VRER 1717
             V +R
Sbjct: 18987 VLDR 18990



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 269   VMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQ 327
             V GKPEP+I W    + L L ++  L Y  +    V+K  +C   D G Y    +N++G 
Sbjct: 22574 VGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIK--FCDRSDSGKYTLTVKNASGT 22631

Query: 328   TLSAVQLHV 336
                +V + V
Sbjct: 22632 KAVSVMVKV 22640



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 22/81 (27%), Positives = 30/81 (37%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G    L   V G PPP + W K    L     L   +   +  L        DAG Y+ 
Sbjct: 13210 AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYIL 13269

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N+ G+      V VL+ P
Sbjct: 13270 TLENSCGKKEYTIVVKVLDTP 13290



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 8/102 (7%)

Query: 1351  LVSVEEPLLVKLVSELTPLTVHEGDDATFRCE-VSPPDADVTWLRNGAVVTPGPQVEMAQ 1409
             L S E P + K   E+  +T   G+ A   C+ V  P  D+ W R G  +    + +M+ 
Sbjct: 24030 LTSGEAPGIRK---EMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSS 24086

Query: 1410  NGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRET 1447
             +G +  LT+   +  D G  T  A    G   TS++L ++ T
Sbjct: 24087 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 24128



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 10/128 (7%)

Query: 1775  LVLSELRAEDAGEVRFQAGPAQS---LALLEVEALPLQMCRHPPREKTVLVGRRAVLEVT 1831
             +V+S  R    G +R Q G + +   +A +E+  +  Q+  H   E+   V  + V ++ 
Sbjct: 25039 MVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIM-HAVGEEGGHV--KYVCKIE 25095

Query: 1832  VSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDST 1887
                    V W     +L   +KYE+        L + D+   D GTY C+     G+DS+
Sbjct: 25096 NYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS 25155

Query: 1888  HTRLLVEG 1895
             +  L V+G
Sbjct: 25156 YAELFVKG 25163



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 51/238 (21%), Positives = 89/238 (37%), Gaps = 41/238 (17%)

Query: 965   SGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYK 1024
             S EY   +  E+    V V+EPP+    P   VTL+ VT           R  A ++W K
Sbjct: 18778 SNEYGIGLPAETTE-PVKVSEPPL----PPGRVTLVDVT-----------RNTATIKWEK 18821

Query: 1025  ---DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVT----AP 1077
                DG        + ++  G          +  +       AG++  F    V     + 
Sbjct: 18822 PESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSD 18881

Query: 1078  PERIVHPA-ARSLDLH---------FGAPGRVELRCEVAPAG---SQVRWYKDGLEVEAS 1124
             P ++  P  AR +++          F    R +L+ +V   G   + V W KDG  ++ +
Sbjct: 18882 PRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKET 18941

Query: 1125  DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
               + + +     +L++  A  ED G Y     + A +  V     P+  + L+    P
Sbjct: 18942 TRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITV-----PITIIVLDRPGPP 18994



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 8/116 (6%)

Query: 487   VTREDAGEVTFSLGNSRTTTLLRVKCVKH-SPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
             V  E+A  V  + G SR      +KC +  +PPGPP + ++    K TV L W  P    
Sbjct: 21730 VMAENAAGVGPASGISRL-----IKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDG 21784

Query: 546   ETPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGR 600
                 I Y +E  +    DW +  + E           + +  +Y+FR+  ++G G+
Sbjct: 21785 GMEIIGYIIEMCKADLGDWHK-VNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGK 21839



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 30/114 (26%), Positives = 48/114 (42%), Gaps = 7/114 (6%)

Query: 489  REDAGEVTFSLGN--SRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPE 546
            R D G       N   R T ++ V  +    PGPP   ++      + LLTW PP     
Sbjct: 7258 RSDTGTYIIEAVNVCGRATAVVEVNVL--DKPGPPAAFDITDVTNESCLLTWNPPRDDGG 7315

Query: 547  TPFI-YRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHG 599
            +    Y +ER+   SE W +  S  K    +     +P++ +Y FR+   + +G
Sbjct: 7316 SKITNYVVERRATDSEVWHKLSSTVKDTNFKAT-KLIPNK-EYIFRVAAENMYG 7367



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 19/79 (24%), Positives = 36/79 (45%)

Query: 925  PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVT 984
            P   V W KDG+EV  S  L ++ +     L +P     D+G Y   ++++  S T ++ 
Sbjct: 7917 PVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASIN 7976

Query: 985  EPPVRIIYPRDEVTLIAVT 1003
               + +  P  ++    +T
Sbjct: 7977 VKVIGLPGPCKDIKASDIT 7995



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 16/55 (29%), Positives = 30/55 (54%)

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
            V W+KDG+EV+ SD + ++N+     L +P +  +D G +     ++    T +I
Sbjct: 7921 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASI 7975



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 17/40 (42%), Positives = 24/40 (60%)

Query: 1112 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
            V W+KDG EV+ASD L +  +  +  L +P +   DAG Y
Sbjct: 7921 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 7960



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 18/57 (31%), Positives = 29/57 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT 980
             +P    +W K  +EVV S  L + K D+   L++  V  +DSG Y    ++ S + T
Sbjct: 12428 KPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDT 12484



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 15/149 (10%)

Query: 748   TWYKDGQKV---EESELLVVKMDGRKHRLILPEAKVQDSGEF------ECRTEGVSAFFG 798
             TWYK GQK+   +  +    + D   ++L +      D  E+      +   +   A   
Sbjct: 25225 TWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLT 25284

Query: 799   VTVQDPPVH--IVDPREHVFVHAITSECVMLACEVDREDAP---VRWYKDGQEVEESDFV 853
             VT+  PP    +    + +  +A   E   +  E+     P   ++W KDGQ +     +
Sbjct: 25285 VTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNI 25344

Query: 854   VLENEG-PHRRLVLPATQPSDGGEFQCVA 881
              + +EG  +  L +  T P D G ++  A
Sbjct: 25345 EIIHEGLDYYALHIRDTLPEDTGYYRVTA 25373



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 18   PRPVRVVSGAEAELKC--------VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            PRP+ ++ G   +  C        V +       VW K GQ++  S+R+    D   H L
Sbjct: 2307 PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2366

Query: 70   LLTAALPTDAGVY 82
            L+      DAG Y
Sbjct: 2367 LIEDMTKEDAGNY 2379



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 18/60 (30%), Positives = 30/60 (50%)

Query: 482   LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
             LV+  VTR D+G    +L N+  +    V       P  P+   + +  K++V L+W+PP
Sbjct: 18666 LVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPP 18725



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 41/171 (23%), Positives = 64/171 (37%), Gaps = 28/171 (16%)

Query: 63    DGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPG 122
             D +E    +T   P D   +   ARNA G        T+  P  S   +   +  +P   
Sbjct: 21410 DVSECQYTVTGLSPGDRYEFRIIARNAVG--------TISPPSQSSGIIMTRDENVP--- 21458

Query: 123   SGEGAPVFLTGPR---SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                  P+   GP       +  G  + +     G P P + W KDG+ +++  +      
Sbjct: 21459 -----PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---- 21509

Query: 180   QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPP 230
                   D  G S +L +  A     GVY   A+NA G A+A   ++V   P
Sbjct: 21510 ----ITDVLG-STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 21555



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 22/91 (24%), Positives = 41/91 (45%), Gaps = 1/91 (1%)

Query: 1183  LCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG 1241
             L +  GE + +   +     P V W  +G  +++   +E+        L ++ A   H G
Sbjct: 21471 LIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 21530

Query: 1242  LYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
             +YT ++  A G+      V+V + P +VV P
Sbjct: 21531 VYTVEAKNASGSAKAEIKVKVQDTPGKVVGP 21561



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 39/167 (23%), Positives = 65/167 (38%), Gaps = 32/167 (19%)

Query: 453   LEAGVEGR------WSRDGEELPVICQSSS----GHMHALVLPGVTREDAGEVTFSLGNS 502
             L+A V G+      W++  +EL  +C+  S    G     V+    R D+G+ T ++ N+
Sbjct: 22570 LDAAVGGKPEPKIIWTKGDKELD-LCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNA 22628

Query: 503   RTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWK-PPEPAPETPFIYRLERQEVGSE 561
               T  + V       PGP     + +  +    L W  P E        Y +ER+E    
Sbjct: 22629 SGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRL 22688

Query: 562   DWIQCFSIEKAGAVEVPGDC---------VPSEGDYRFRICTVSGHG 599
             +W           V V G+C         +    +Y FR+  V+ +G
Sbjct: 22689 NW-----------VIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYG 22724



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 1/67 (1%)

Query: 1721  VLSELRSVSAREGDGATFEC-TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
             +L++ RS++  EG+ A F C T  E   T  W   G+ L   AR ++     K    +S 
Sbjct: 26066 ILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISS 26125

Query: 1780  LRAEDAG 1786
             ++A D G
Sbjct: 26126 VQASDEG 26132



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 9/97 (9%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            V  G ++ L     G PEP + W K  M L +        +     E+ P  S  + I+ 
Sbjct: 7205 VKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITI-----ENVPKKS-TVTIVD 7255

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPA 235
            ++  D+G Y+  A N  G A A   + V   P  P A
Sbjct: 7256 SKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAA 7292



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 32/111 (28%), Positives = 44/111 (39%), Gaps = 11/111 (9%)

Query: 134   PRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193
             P    +  G ++ +     G P PT  W+K     DEV  SSH A+          +S  
Sbjct: 12408 PEQITIKAGKKLRIEAHVYGKPHPTCKWKK---GEDEVVTSSHLAVHKA------DSSSI 12458

Query: 194   LRILAARLPDSGVYVCHARNAHG-HAQAGALLQVHQP-PESPPADPDEAPA 242
             L I      DSG Y   A N+ G   Q   ++ +  P P  PP D  +  A
Sbjct: 12459 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDA 12509



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 13/89 (14%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             RP  EV+W +D  E ++  +  ++   +   L++  V   DSG+Y+  +++ S S +  V
Sbjct: 15390 RPAPEVKWARDHGESLDKAS--IESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 15447

Query: 984   TEPPVRII----YPRD----EVTLIAVTL 1004
                 VR++     P+D    EVT  +VTL
Sbjct: 15448 N---VRVLDTPGPPQDLKVKEVTKTSVTL 15473



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 1640  VTEGDTATFECEL-SQALADVTWEKDGNAL-TPSPRLRLQALGTRRLLQLRRCGPSDAGT 1697
             V  G+T   E ++  + + DV W KDG  L   + R+ +++   +  L ++ C  +D G 
Sbjct: 18222 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQ 18281

Query: 1698  YSCA---VGTARAGPVRLTVRER 1717
             Y      VG  ++ P+ + V +R
Sbjct: 18282 YILKLSNVGGTKSIPITVKVLDR 18304



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 512   CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             C  + PPGPP   E+    K+++++TW  P     T    Y LE+++     W +C
Sbjct: 18399 CNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKC 18454



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 29/119 (24%), Positives = 53/119 (44%), Gaps = 10/119 (8%)

Query: 491   DAGEVTFSLGNSRTTTLLRVKCVKHSPPGPP----ILAEMFKGHKNTVLLTWKPPE-PAP 545
             DAG    +  NS  TT   +  V    PGPP    +++++    + +V L W+PP+    
Sbjct: 20046 DAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDI---TEESVTLKWEPPKYDGG 20102

Query: 546   ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
                  Y L ++E  +  W +  +      ++V    + +  +Y+FRI   +  G S H+
Sbjct: 20103 SQVTNYILLKRETSTAVWTEVSATVARTMMKVMK--LTTGEEYQFRIKAENRFGISDHI 20159



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 24/92 (26%), Positives = 36/92 (39%), Gaps = 2/92 (2%)

Query: 16    RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
             R+   + V  G    L   + G+P P+  W K GQ +  S+R           L++  A 
Sbjct: 23644 RYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI--SKRAMIATSETHTELVIKEAD 23701

Query: 76    PTDAGVYVCRARNAAGEAYAAAAVTVLEPPAS 107
               D+G Y     N  G+      V V+  P S
Sbjct: 23702 RGDSGTYDLVLENKCGKKAVYIKVRVIGSPNS 23733



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 33/158 (20%), Positives = 60/158 (37%), Gaps = 22/158 (13%)

Query: 720  PQDRVSLTFTTSERVVLTCELSRVDFP--------ATWYKDGQKVEESELLVVKMDGRKH 771
            P  + ++   T + +V+  E   +  P         +W+KDG++V+ S+ L +K D    
Sbjct: 7886 PDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISA 7945

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEV 831
             L +P++   D+G +    E        ++    + +  P + +    IT     L  E 
Sbjct: 7946 HLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEP 8005

Query: 832  DRED--APVRWYKDGQEVEESDFVVLENEGPHRRLVLP 867
               D   P+  Y            VLE     RR  +P
Sbjct: 8006 PEFDGGTPILHY------------VLERREAGRRTYIP 8031



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 1638  LEVTEGDTATFECEL-SQALADVTWEKDGNA--LTPSPRLRLQALGTRRLLQLRRCGPSD 1694
             L V  GDT   E  +  +   +V W KD +A  LT SPR+++          L +   SD
Sbjct: 11714 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSD 11773

Query: 1695  AGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV-SAREGDGATFECTV 1742
              G Y     T  AG     V   TV VL +   V + +  D ++  CTV
Sbjct: 11774 GGKY-VVTATNTAGSF---VAYATVNVLDKPGPVRNLKIVDVSSDRCTV 11818



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 17/173 (9%)

Query: 1096  PGRVELRCEVAPAG-SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE 1154
             PG   +RC  AP    Q  +   GLE +A    Q  A   T     P ++P D    + E
Sbjct: 12735 PGDKWVRCNTAPHQIPQEEYTATGLEEKAQ--YQFRAIARTAVNISPPSEPSDPVTILAE 12792

Query: 1155  TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPV 1213
                  I  +V +              S L V  G  V L   +     P V W  +G  +
Sbjct: 12793 NVPPRIDLSVAMK-------------SLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLL 12839

Query: 1214  QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
             +  EG+++  +     L + +     +G YT  +  + G+ S +  ++V + P
Sbjct: 12840 KPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 12892



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K+TV L W KP          Y +E Q  GS+ W    +++  G   
Sbjct: 14468 PSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVK--GLEC 14525

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V  +    E +Y F++  V+  GRS
Sbjct: 14526 VVRNLTEGE-EYTFQVMAVNSAGRS 14549



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 26/102 (25%), Positives = 41/102 (40%), Gaps = 8/102 (7%)

Query: 232   SPPADP-------DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGR 284
             SPP++P       D+  AP ++       T  +  G+  +    V G+P P +EW  +G+
Sbjct: 14944 SPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGK 15003

Query: 285   PLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG 326
               L    +L  +  D    L       +D G Y   A N  G
Sbjct: 15004 E-LEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGG 15044



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 20/87 (22%), Positives = 36/87 (41%)

Query: 833   REDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI 892
             R  A V W KDGQ ++E+  V + +      L +      D G ++    +     TV I
Sbjct: 18924 RPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPI 18983

Query: 893   TDVSSWIVYPSGKVYVAAVRLERVVLT 919
             T +      P G + +  V  + + ++
Sbjct: 18984 TIIVLDRPGPPGPIRIDEVSCDSITIS 19010



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    K++V LTW  PE    +  + Y +E  E G ++W++C ++ K+    
Sbjct: 19878 PSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKC-AVAKSTHHV 19936

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             V G  +    +Y FR+   +  G S
Sbjct: 19937 VSG--LRENSEYFFRVFAENQAGLS 19959



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 3/63 (4%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD---ESASFT 980
             RP   V W KD + +       ++  D+   L +P V   D+G+Y+  I++   E  S T
Sbjct: 20801 RPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 20860

Query: 981   VTV 983
             V+V
Sbjct: 20861 VSV 20863



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 23/89 (25%), Positives = 35/89 (39%), Gaps = 9/89 (10%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G+++VL    GG PEP + W K    LD          +      G  A+  ++      
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWTKGDKELD-------LCEKVSLQYTGKRATAVIKF--CDR 22615

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPP 230
              DSG Y    +NA G      +++V   P
Sbjct: 22616 SDSGKYTLTVKNASGTKAVSVMVKVLDSP 22644



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 2/75 (2%)

Query: 1637  DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
             D+    G+ A   C++  + L D+ W + G  L  S + ++ + G    L +      D 
Sbjct: 24044 DVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 24103

Query: 1696  GTYSCAVGTARAGPV 1710
             G Y+C + T   G V
Sbjct: 24104 GVYTC-IATNEVGEV 24117



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 18/76 (23%), Positives = 32/76 (42%)

Query: 37   GEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAA 96
            G P P   W  G + L   +R+      A   L+++ +  +D G+Y  +  N        
Sbjct: 6923 GYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGE 6982

Query: 97   AAVTVLEPPASDPELQ 112
              V V+  P++  EL+
Sbjct: 6983 IDVNVIARPSAPKELK 6998



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)

Query: 517  PPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDW 563
            PP PP   E+    KNT  L W  PE    +P   Y +E+++V  + W
Sbjct: 7586 PPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGW 7633



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 8/99 (8%)

Query: 25   SGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADG----AEHG--LLLTAALP 76
            +G++  +  V+ G P P   WE  G+   A +      P D     AE+   +++     
Sbjct: 9327 AGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKR 9386

Query: 77   TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
            +  G Y   A+N AG+  A   V V++ P    +L+ ++
Sbjct: 9387 SHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSD 9425



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 6/70 (8%)

Query: 924   RPWAEVRWTKDGE--EVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF-- 979
             +P+ EV WTKD +  ++  SP + +       +  L   +  D G+Y+    + + SF  
Sbjct: 11731 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVA 11790

Query: 980   --TVTVTEPP 987
               TV V + P
Sbjct: 11791 YATVNVLDKP 11800



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 19/81 (23%), Positives = 34/81 (41%)

Query: 25    SGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVC 84
             +G+   +   + G P P V W+    +L  ++R+S         L +  ++  D+G Y  
Sbjct: 22164 AGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFL 22223

Query: 85    RARNAAGEAYAAAAVTVLEPP 105
                N AG    +  V V+  P
Sbjct: 22224 TLENTAGVKTFSVTVVVIGRP 22244



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 4/93 (4%)

Query: 1432  RAGSTATSARLHVRETELLFLRR-LQDVRAEEGQDVCLEVE-TGRVGAAGAVRWVRGGQP 1489
             R   TA S +  +   E   +R+ ++DV  + G+   L  +  GR      ++W R G+ 
Sbjct: 24018 RPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGR--PLPDIKWYRFGKE 24075

Query: 1490  LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC 1522
             L    +  M+ DG  H L +      D+G Y C
Sbjct: 24076 LIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 24108



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 15/102 (14%)

Query: 21    VRVVSGAEAELKCVVLGEPPPVVVWEKGG-------QQLAASERLSFPADGAEHGLLLTA 73
             V V +G    L  +V G P P V W K G        Q+   + ++F        L++  
Sbjct: 12119 VIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAF--------LVIPN 12170

Query: 74    ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAE 115
             +   D+G Y     N AGE      V VL+ P    +L+ ++
Sbjct: 12171 STRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSD 12212



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 16/60 (26%), Positives = 30/60 (50%)

Query: 924   RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTV 983
             +P   V W KDG  +  +  + +  +  +  L L +V  +DSG+Y    ++ S S + T+
Sbjct: 12825 KPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATI 12884



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 14/38 (36%), Positives = 22/38 (57%)

Query: 1114  WYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
             W K G ++  SD  Q+ +   +  LT+ +A  +DAGEY
Sbjct: 13916 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEY 13953



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 1/84 (1%)

Query: 517   PPGPPILAEMFKGHKNTVLLTW-KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAV 575
             PPGPP    +    K +  L W KP          Y +E Q+VG E WI+  +       
Sbjct: 14175 PPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRIT 14234

Query: 576   EVPGDCVPSEGDYRFRICTVSGHG 599
             +     + ++  Y FRI  ++  G
Sbjct: 14235 QFVVPDLQTKEKYNFRISAINDAG 14258



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 7/97 (7%)

Query: 1081  IVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGLEVEASDALQLGAEGPTRT 1137
             ++ PA + L   F      +L+ +V   G     V W+KD + ++ +  +   +      
Sbjct: 15648 VIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSL 15707

Query: 1138  LTLPHAQPEDAGEYVCETRH---EAI-TFNVILAEPP 1170
             LT+  A  ED G YV +  +   EAI T NVI+ + P
Sbjct: 15708 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15744



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 38/148 (25%), Positives = 56/148 (37%), Gaps = 23/148 (15%)

Query: 93    AYAAAAVTVL---EPPASDPELQPAER-PLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLT 148
             ++  AAV V    E   S  E++P ER  +P     +     +T      +  GA + L 
Sbjct: 22917 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVT------IRAGASLRLM 22970

Query: 149   CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRIL-AARLPDSGVY 207
                 G P P + W K G+ L              RA      S +L I+      D+G Y
Sbjct: 22971 VSVSGRPPPVITWSKQGIDL------------ASRAIIDTTESYSLLIVDKVNRYDAGKY 23018

Query: 208   VCHARNAHGHAQAGALLQVHQPPESPPA 235
                A N  G   A  L++V+  P   P+
Sbjct: 23019 TIEAENQSGKKSATVLVKVYDTPGPCPS 23046



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 32/110 (29%), Positives = 49/110 (44%), Gaps = 21/110 (19%)

Query: 424 VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDGE-----ELPVIC 472
           +T + P   +  + + VLEG  A     T EA + G       W RDG+      LP + 
Sbjct: 1   MTTQAPTFTQPLQSVVVLEGSTA-----TFEAHISGFPVPEVSWFRDGQVISTSTLPGVQ 55

Query: 473 QSSSGHMHALVLPGVTREDAG----EVTFSLGNSRTTTLLRVKCVKHSPP 518
            S S     L +P VT+ ++G    + T   G + +T  L VK  + +PP
Sbjct: 56  ISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK-AETAPP 104



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 47/196 (23%), Positives = 80/196 (40%), Gaps = 24/196 (12%)

Query: 343 FTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRL----LPCRKYEQIEEGTVRRL 397
           FT+PLQ V   E   A  E  +    +P  +WFR+ Q +    LP  +     +G  +  
Sbjct: 8   FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQI-SFSDGRAKLT 66

Query: 398 IIHRLKADDD--GIYLCEMRGRVRTVANVTVKG----PILKRLPRKLDVLEGENAVLLVE 451
           I    KA+     +      G+  + A + VK     P   +  + + V +G    L V 
Sbjct: 67  IPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVR 126

Query: 452 TLEAGVEG---RWSRDGEELPVICQ---SSSGHMHALVLPGVTREDAG----EVTFSLGN 501
               G+     ++ RDG E+        S  G +++L++     ED+G      T S+G 
Sbjct: 127 V--TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR 184

Query: 502 SRTTTLLRVKCVKHSP 517
           + +T  L V+  +  P
Sbjct: 185 ATSTAELLVQGEEEVP 200



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 22/104 (21%), Positives = 45/104 (43%), Gaps = 2/104 (1%)

Query: 1630 TIVRGPHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPRLRLQALGTRRLLQLR 1688
            TI    HD+ V EG+  +         +  V+W KDG  +  S RL ++       L++ 
Sbjct: 7891 TIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVP 7950

Query: 1689 RCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSARE 1732
            +   +DAG Y+  +   + G    ++  + + +    + + A +
Sbjct: 7951 KSVRADAGIYTITLEN-KLGSATASINVKVIGLPGPCKDIKASD 7993



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 26/112 (23%), Positives = 42/112 (37%), Gaps = 8/112 (7%)

Query: 232  SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR 291
            S    P +   P + P     +   V EG +      + G P P + W ++  P  PD +
Sbjct: 9606 SATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTW-FKAPPKKPDNK 9664

Query: 292  RLMYRDR-------DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
              +  D        D    L +   +  D GLY   A N+ G     ++L+V
Sbjct: 9665 EPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9716



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 2/88 (2%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             PG P    +    K  V L W+ P+    +P + Y +ER+  GS+DW +           
Sbjct: 11604 PGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHY 11663

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRSPHV 604
             +   CV ++  Y FR+ T +  G S  V
Sbjct: 11664 MVDRCVENQ-IYEFRVQTKNEGGESDWV 11690



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%)

Query: 153   GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHAR 212
             G P+PT+ W+K    L +    +          +    S  L I      DSG Y   AR
Sbjct: 14594 GRPKPTVTWKKGDQILKQTQRVNF---------ETTATSTILNINECVRSDSGPYPLTAR 14644

Query: 213   NAHGHAQAGALLQVHQPPESPPADP 237
             N  G       +QVH  P  PP  P
Sbjct: 14645 NIVGEVGDVITIQVHDIP-GPPTGP 14668



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 13/40 (32%), Positives = 20/40 (50%)

Query: 1659  VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
             VTW+K    L  + R+  +   T  +L +  C  SD+G Y
Sbjct: 14600 VTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPY 14639



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 15/53 (28%), Positives = 29/53 (54%), Gaps = 1/53 (1%)

Query: 515   HSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQC 566
             + PP PP   E+    K+++++ W  P+    +  I Y +ER++   + WI+C
Sbjct: 15155 YGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKC 15207



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 4/85 (4%)

Query: 518   PGPPILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQCFSIEKAGAVE 576
             P PP    +    +N+V L+W+ PE    +  + Y +E Q  GS+ W  C ++ K     
Sbjct: 15552 PLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATV-KVTEAT 15610

Query: 577   VPGDCVPSEGDYRFRICTVSGHGRS 601
             + G  +  E +Y FR+   +  G S
Sbjct: 15611 ITG-LIQGE-EYSFRVSAQNEKGIS 15633



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 29/107 (27%), Positives = 40/107 (37%), Gaps = 10/107 (9%)

Query: 142   GAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARL 201
             G  V L     G P PT+ W KD    D+   ++         +       ++ I  A  
Sbjct: 20390 GTSVKLRAGISGKPAPTIEWYKD----DKELQTNALVCVENTTD-----LASILIKDADR 20440

Query: 202   PDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
              +SG Y    RNA G A A   +Q+   P  PP  P E      E +
Sbjct: 20441 LNSGCYELKLRNAMGSASATIRVQILDKP-GPPGGPIEFKTVTAEKI 20486



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 18/77 (23%), Positives = 33/77 (42%), Gaps = 1/77 (1%)

Query: 260   GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
             G   K R  + GKP P IEW+ + + L  +    +    D   +L +      + G Y  
Sbjct: 20390 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL-IKDADRLNSGCYEL 20448

Query: 320   AARNSAGQTLSAVQLHV 336
               RN+ G   + +++ +
Sbjct: 20449 KLRNAMGSASATIRVQI 20465



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 24/83 (28%), Positives = 29/83 (34%), Gaps = 2/83 (2%)

Query: 23    VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
             V +GA   L     G P P  VW K    L  S R       +   L +      DAG Y
Sbjct: 21872 VRAGASIRLFIAYQGRPTPTAVWSKPDSNL--SLRADIHTTDSFSTLTVENCNRNDAGKY 21929

Query: 83    VCRARNAAGEAYAAAAVTVLEPP 105
                  N +G       V VL+ P
Sbjct: 21930 TLTVENNSGSKSITFTVKVLDTP 21952


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  321 bits (823), Expect = 4e-87
 Identities = 516/2007 (25%), Positives = 766/2007 (38%), Gaps = 277/2007 (13%)

Query: 18   PRPVR--VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
            P PV   V+  A   L+C+  G PPP V W KG Q +++   ++   DG    L +  A 
Sbjct: 699  PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQ 756

Query: 76   PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR 135
             +DAG Y C A N AG       + V  PP     L P+   LP P              
Sbjct: 757  LSDAGSYRCVASNVAGSTELRYGLRVNVPPRI--TLPPS---LPGP-------------- 797

Query: 136  SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALR 195
               VL    V LTC A G P PTL W KDG  +             GR          L 
Sbjct: 798  ---VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR---------VLT 845

Query: 196  ILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTF 255
            + +AR  DSG Y C A +A G  +   +LQVH P           P+ + E L  +    
Sbjct: 846  LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMP-----------PSILGEELNVS---- 890

Query: 256  WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRG 315
             V   +     C     P P + W  +GRPL P     +  D+    +L+V      D G
Sbjct: 891  -VVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK---ALLQVDRADVWDAG 946

Query: 316  LYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFR 375
             Y C A N AG++     L+V    +   R    +  RE     L C+      P   +R
Sbjct: 947  HYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWR 1006

Query: 376  EDQRLLPCRKYEQIEEGTVRRLI-IHRLKADDDGIYLCEMRGRVRTVAN---------VT 425
            +D + LP           V RL+ + + +   +G Y CE    V   +            
Sbjct: 1007 KDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 1066

Query: 426  VKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGE----ELPVICQSS 475
            + GP  +  P ++ V++       V TLE    G+      W RDG+    EL +  Q+ 
Sbjct: 1067 IAGP--REPPTQVSVVQDG-----VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ 1119

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNS-----RTTTLLRVKCVKHSPPGPPILAEMFKGH 530
               +H              V  +L          + L+  + +    P   I A +   H
Sbjct: 1120 GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAAL---H 1176

Query: 531  KNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRF 590
                LL      P P   +    E    G + ++    +     +++        G Y  
Sbjct: 1177 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYL----LAGGWMLKMTQTQEQDSGLYSC 1232

Query: 591  RICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDV-QVYDGEDAVFSLDLSTIIQG--TW 647
                 +G  R    V      LVP +     LE+V +V DG+ A    +++   Q   TW
Sbjct: 1233 LASNEAGEARRNFSV----EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW 1288

Query: 648  FLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA 707
            F +G  L   +    + P  +  ++ Q  L        +    +   VG      Q    
Sbjct: 1289 FKDGRPLARGDAH-HISPDGVLLQVLQANLSSAGHYSCI----AANAVGEKTKHFQ---- 1339

Query: 708  LTIQESPVHILSPQDRV--SLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVV 764
            L++  +P  +   +D     +T T +  + L CE      P  TW KDG   E S    +
Sbjct: 1340 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR--NI 1397

Query: 765  KMDGRKHRLILPEAKVQDSGEFECRT-----EGVSAFFGVTVQDPPVHIVDPREHVFVHA 819
            ++    H L +  A+ +D+G++ C       E V  +    +  P +   DP   V V  
Sbjct: 1398 QLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKE 1457

Query: 820  I---TSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            +    +  + L CE      P +RWYKDGQ V  S  + +  EG  R L +  TQ SD G
Sbjct: 1458 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSDSG 1515

Query: 876  EFQC----VAGDECAYFTVTIT---------------DVSSWIVYPSGKV--YVAAVRLE 914
             + C    VAG++   F V I                ++ S      G V  Y   V   
Sbjct: 1516 RYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENN 1575

Query: 915  RVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC--- 970
               L C+    P  ++ W ++ + +     + + +   V  L +P V+ E++G Y C   
Sbjct: 1576 PAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV--LQIPLVRAENAGRYSCKAS 1633

Query: 971  -EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV-LMCELSREDAP-VRWYKDGL 1027
             E+ ++   + + V  PPV +    + V  + V     V L C       P + W ++GL
Sbjct: 1634 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL 1693

Query: 1028 EVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVH 1083
                S  L +  DG    L +  A+  D   ++C     AG     FT+ V  PP     
Sbjct: 1694 PFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR---- 1747

Query: 1084 PAARSLDLHFGAP---GRVELRCEV-APAGSQVRWYKDGLEVEASDALQLGAE----GPT 1135
                 LDL          V L C+V A    +V WYKD      S AL LG E      T
Sbjct: 1748 --IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKD------SQALSLGEEVFLLPGT 1799

Query: 1136 RTLTLPHAQPEDAGEYVCETRHEA------ITFNVILAEPPVQFLALETTPSPLCVAPGE 1189
             TL L  A+  D+G Y CE  + A      +  +V++  PP    A       + V  G+
Sbjct: 1800 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV--PPAFRQAPRGPQDAVLVRVGD 1857

Query: 1190 PVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
              VLSCE      P V W  +G+P+   +  +    G R  L IQ A  +  GLY+C+  
Sbjct: 1858 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR--LEIQEAQVSDKGLYSCKVS 1915

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGE 1307
               G    +FT+ V  PP            V    G  L L   +SG P   V W KD  
Sbjct: 1916 NVAGEAVRTFTLTVQVPP---TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRM 1972

Query: 1308 RLASQGRVQLEQAGAR-QVLRVQGARSGDAGEYLCDA----PQDSRIFLVSVEEPLLVKL 1362
             + S     +   G R Q+ R+Q A+   AG Y C A     +  + F+V+V     ++ 
Sbjct: 1973 PVESSAVHGVVSRGGRLQLSRLQPAQ---AGTYTCVAENTQAEARKDFVVAVLVAPRIRS 2029

Query: 1363 VSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVV--TPGPQVEMAQNGSSRILTLR 1419
                    V EG +    CE    P  DV WL++G+ +    GP +    +G S  L L+
Sbjct: 2030 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGS--LVLK 2087

Query: 1420 GCQLGDAGTVTLRAGSTA-TSARLHVRETELLFLRRLQDVRAEEGQDVCL--EVETGRVG 1476
            G +  DAG  T  A + A   ARLH     +L    ++      G  V    E+ T    
Sbjct: 2088 GLRASDAGAYTCVAHNPAGEDARLHT--VNVLVPPTIKQGADGSGTLVSRPGELVTMVCP 2145

Query: 1477 AAGA----VRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLA- 1531
              G+    V W++ G PLP   R  +   GH  R  I  V LAD G + C +     +A 
Sbjct: 2146 VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLR--ISKVQLADAGIFTCVAASPAGVAD 2203

Query: 1532 -RLSVRPRQLRVLRPLE---DVTISEGGSATFQLELSQEGV---TGEWARGGVQLYPGPK 1584
               +++ +   VL P+E   DV +  G  +  +L     GV      W + G  L     
Sbjct: 2204 RNFTLQVQVPPVLEPVEFQNDVVVVRG--SLVELPCEARGVPLPLVSWMKDGEPLLS--- 2258

Query: 1585 CHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPH-------- 1636
                S      L L  +G  DSG  S  A S    AR   R   +T++  PH        
Sbjct: 2259 ---QSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR---RHFQLTVMEPPHIEDSGQPT 2312

Query: 1637 DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
            +L +T G      C+       ++TW KDG ALT   RL   +  T R+L++R     DA
Sbjct: 2313 ELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT---RLENNSRAT-RVLRVR-----DA 2363

Query: 1696 GTYSCAVGTARAGPVRLTVRERTVAVLSEL-----RSVSAREGDGATFECTV-SEVETTG 1749
            G Y+C +  + AG +  + R R  A  + +     R V          EC+V +E     
Sbjct: 2364 GLYTC-LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKI 2422

Query: 1750 RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVEA 1805
             W   G  L+  A  +  + G+   L L  L   D+G+     R  AG       +E+  
Sbjct: 2423 TWHRDGIVLQEDAHTQFPERGR--FLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT 2480

Query: 1806 LPLQMCRHPPREKTVLVGRRAVLEVTVSR-SGGHVCWLREGAELCP-GDKYEMRSHGPTH 1863
            +P    R  P    V V + A+L           V W ++   L P   ++E+   G   
Sbjct: 2481 VP--TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG--- 2535

Query: 1864 SLVIHDVRPEDQGTYCCQAGQDSTHTR 1890
            SL I  V  +D G Y C A   +   R
Sbjct: 2536 SLRIQPVLAQDAGHYLCLASNSAGSDR 2562



 Score =  290 bits (743), Expect = 7e-78
 Identities = 509/2005 (25%), Positives = 746/2005 (37%), Gaps = 260/2005 (12%)

Query: 15   LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
            LR    + V  G    L C   G P P + W K GQ L                L L  A
Sbjct: 975  LRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 1034

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
                 G Y C   N  G +     + V  PP      +P                    P
Sbjct: 1035 QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREP--------------------P 1074

Query: 135  RSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG---PGAS 191
                V++     L C A G P PT+ WE+DG              QP  AE G       
Sbjct: 1075 TQVSVVQDGVATLECNATGKPPPTVTWERDG--------------QPVGAELGLQLQNQG 1120

Query: 192  LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCA 251
             +L +  A+   +G Y C A N  G A+    L V  PPE      D  P   +     +
Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE---LIGDLDPLTNITAALHS 1177

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            P T            C  MG P P I W     P+ P     +     GG++LK+   Q 
Sbjct: 1178 PLTLL----------CEAMGIPPPAIRWFRGEEPVSPGEDTYLLA---GGWMLKMTQTQE 1224

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDV-EGREHGIAVLECKVPNSRIP 370
            +D GLY C A N AG+      + V  P       L++V +  +   A L C V     P
Sbjct: 1225 QDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1284

Query: 371  -TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRV---------RT 420
               WF++ + L     +    +G + +++   L +   G Y C     V           
Sbjct: 1285 KLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSS--AGHYSCIAANAVGEKTKHFQLSV 1342

Query: 421  VANVTVKGPILKRLPRKLDVLEGENAVLLVETLE-AGVEGRWSRDGE--ELPVICQSSSG 477
            +   T+ G        ++ V       L+ E L        W +DG   E     Q   G
Sbjct: 1343 LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG 1402

Query: 478  HMHALVLPGVTREDAGE----VTFSLG----NSRTTTLLRVKCVKHSPPGPPILAEMFKG 529
              H L +    +EDAG+    VT  LG    N     L+     K  P G   + E+   
Sbjct: 1403 -THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTK 1461

Query: 530  HKNTVLL---TWKPPEPA--------PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVP 578
              +T+ L   +W  P P         P TP   RL+    G    IQ   +  +G     
Sbjct: 1462 VNSTLTLECESWAVPPPTIRWYKDGQPVTP-SSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1520

Query: 579  GDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAG--LEDVQVYDGEDAVFS 636
               V  E D  F +             F  +  ++       G   E  ++ +   A   
Sbjct: 1521 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1580

Query: 637  LDLSTIIQG--TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGAL 694
             D + I     TW+   + L + +    ++ G +            L +  V+ +++G  
Sbjct: 1581 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV------------LQIPLVRAENAGR- 1627

Query: 695  VGFSCPGVQDSA------ALTIQESPVHILSPQDRV-SLTFTTSERVVLTCELSRVDFPA 747
              +SC    +         L +   PV +   ++ V  +T   S  V L C       P 
Sbjct: 1628 --YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPT 1685

Query: 748  -TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE----GVSAFFGVTVQ 802
             +W ++G     S  L V  DG+   L +  A+V D+  + C  E         F + VQ
Sbjct: 1686 ISWLQNGLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1743

Query: 803  DPP-VHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGP 860
             PP +  +D  +   V AI +  V L C+V     P V WYKD Q +   + V L   G 
Sbjct: 1744 VPPRIAGLDLEQ---VTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL-LPGT 1799

Query: 861  HRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRL-ER 915
            H  L L   + SD G + C     AG +     +++    ++   P G      VR+ ++
Sbjct: 1800 H-TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK 1858

Query: 916  VVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVR---RLVLPAVQLEDSGEYLCE 971
             VL+CE    P   V W KDG+     P +L Q+   +R   RL +   Q+ D G Y C+
Sbjct: 1859 AVLSCETDALPEPTVTWYKDGQ-----PLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCK 1913

Query: 972  IDDESA----SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDG 1026
            + + +     +FT+TV  PP     P+ E T+  V    +VL C++S   AP V W KD 
Sbjct: 1914 VSNVAGEAVRTFTLTVQVPPT-FENPKTE-TVSQVAGSPLVLTCDVSGVPAPTVTWLKDR 1971

Query: 1027 LEVEESEAL-VLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA----FFTVTVTAPPERI 1081
            + VE S    V+ R G   RL L   QP   G + C A +  A     F V V   P   
Sbjct: 1972 MPVESSAVHGVVSRGG---RLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR 2028

Query: 1082 VHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDG--LEVEASDALQLGAEGPTRTLT 1139
                AR   +  G   R++   +  P    V W KDG  L  +    L+   +G   +L 
Sbjct: 2029 SSGVAREHHVLEGQEVRLDCEADGQPP-PDVAWLKDGSPLGQDMGPHLRFYLDG--GSLV 2085

Query: 1140 LPHAQPEDAGEYVCETRHEA------ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVL 1193
            L   +  DAG Y C   + A       T NV++  PP      + +   L   PGE V +
Sbjct: 2086 LKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV--PPTIKQGADGS-GTLVSRPGELVTM 2142

Query: 1194 SCELSRAGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAA 1250
             C +   G+P   V W  +G P+   +   LH  G    L I     A AG++TC + + 
Sbjct: 2143 VCPV--RGSPPIHVSWLKDGLPLPLSQRTLLHGSG--HTLRISKVQLADAGIFTCVAASP 2198

Query: 1251 PGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERL 1309
             G    +FT+QV  PP  V+ P   Q  V    G  +EL     G   P V W KDGE L
Sbjct: 2199 AGVADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 2256

Query: 1310 ASQGRVQLEQAGARQVLRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSE 1365
             SQ    LEQ  +   L+++   +GD+G Y C    +A +  R F ++V EP  ++   +
Sbjct: 2257 LSQ---SLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQ 2310

Query: 1366 LTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             T L++  G      C+    P  ++TW ++G  +T        +N S     LR   + 
Sbjct: 2311 PTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT------RLENNSRATRVLR---VR 2361

Query: 1425 DAGTVTL----RAGSTATSARLHVR-ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAG 1479
            DAG  T      AG+   S R+ V+    ++  R  + V       + LE        A 
Sbjct: 2362 DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSV-EAEPAP 2420

Query: 1480 AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPR- 1538
             + W R G  L  D+     + G    L +  +  AD G Y C + +      ++ R   
Sbjct: 2421 KITWHRDGIVLQEDAHTQFPERGRF--LQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2478

Query: 1539 ----QLRVLRPLEDVTISEGGSATFQLELSQEGVTG---EWARGGVQLYP-GPKCHIHSD 1590
                 +R   P  +V++++    T  L    +GV      W +  V L P  P+  I  +
Sbjct: 2479 HTVPTIRSGPPAVNVSVNQ----TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPE 2534

Query: 1591 GHRHRLVLNGLGLADSG----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTA 1646
            G    L +  +   D+G      S +A S R    L V E P  I   P +L +T    A
Sbjct: 2535 G---SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPSNLTLTAHTPA 2590

Query: 1647 TFECELSQALAD-VTWEKDGNALTPSPRLRLQALGTRRL----LQLRRCGPSDAGTYSCA 1701
               CE S +    V W KDG  L      RLQ    R L    L L   GP D+  + C 
Sbjct: 2591 LLPCEASGSPKPLVVWWKDGQKLD----FRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 2646

Query: 1702 VGTARAGPVRL---TVR-ERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRP 1757
            V        RL   TV    T+A      +V+       T   T     T    + G + 
Sbjct: 2647 VSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQL 2706

Query: 1758 LRPGARVRIRQEGKKHILVLSELRA-EDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPR 1816
               G+  R+   G   I     + A       R  AG A     L V+A P+      P 
Sbjct: 2707 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVV----KPL 2762

Query: 1817 EKTVLVGRRAVLEVTVSRSG---GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE 1873
               V       + +    SG     + W +EG  +  G   ++    P   L I    PE
Sbjct: 2763 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVL---PGGQLRIAHASPE 2819

Query: 1874 DQGTYCC----QAGQDSTHTRLLVE 1894
            D G Y C     AG     TRL+V+
Sbjct: 2820 DAGNYLCIAKNSAGSAMGKTRLVVQ 2844



 Score =  266 bits (679), Expect = 2e-70
 Identities = 487/1940 (25%), Positives = 719/1940 (37%), Gaps = 279/1940 (14%)

Query: 78   DAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQ 137
            D G+Y C A N AGE+    A+ VL PP  +P                       GP ++
Sbjct: 668  DEGIYTCAATNLAGESKREVALKVLVPPNIEP-----------------------GPVNK 704

Query: 138  WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRIL 197
             VL  A V L C A G+P P + W K    +   W     ++  GR          LRI 
Sbjct: 705  AVLENASVTLECLASGVPPPDVSWFKGHQPVSS-WMGVTVSVD-GR---------VLRIE 753

Query: 198  AARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWV 257
             A+L D+G Y C A N  G  +    L+V+ PP      P   P PV+           V
Sbjct: 754  QAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRI--TLPPSLPGPVL-----------V 800

Query: 258  NEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
            N     +  C   G P P + W  +G P+ P     + +   GG VL +   +A D G Y
Sbjct: 801  N--TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGL-QVFPGGRVLTLASARASDSGRY 857

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPT-AWFRE 376
             C A ++ G+    V L V  P       L         +A LEC+      P  +W+++
Sbjct: 858  SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA-LECQSHAMPPPVLSWWKD 916

Query: 377  DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM-----RGRVRTVANVTVKGPIL 431
             + L P        +  +  L + R    D G Y CE      R       NV V     
Sbjct: 917  GRPLEPRPGVHLSADKAL--LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFP 974

Query: 432  KRLPRKLDVLEGENAVLLVETLEAGV---EGRWSRDGEELP---VICQSSSGHMHALVLP 485
             R    L V EG    L  E    GV   +  W +DG+ LP      Q  S     L L 
Sbjct: 975  LRESHTLTVREGHPTSLSCEC--RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLG 1032

Query: 486  GVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP------GPPILAEMFKGHKNTV--LLT 537
                   G  T    N    +   ++   H PP       PP    + +    T+    T
Sbjct: 1033 QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT 1092

Query: 538  WKPPEPAPETPFIYRLERQEVGSEDWI------QCFSIEKA-----GAVEVPGDCVPSEG 586
             KPP         +  + Q VG+E  +      Q   +E+A     G      + +    
Sbjct: 1093 GKPPPTV-----TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147

Query: 587  DYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT 646
            + +F +  +      P ++      L P   + A L        E     +    I    
Sbjct: 1148 ERKFELSVLV----PPELI----GDLDPLTNITAALHSPLTLLCE--AMGIPPPAI---R 1194

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSA 706
            WF  GEE         V PG   Y +    +   L +   + QDSG    +SC    + A
Sbjct: 1195 WF-RGEE--------PVSPGEDTYLLAGGWM---LKMTQTQEQDSGL---YSCL-ASNEA 1238

Query: 707  ALTIQESPVHILSPQDRVSLTFTTSERVV---------LTCELSRVDFP-ATWYKDGQKV 756
                +   V +L P    S+     E V+         L C ++    P  TW+KDG+ +
Sbjct: 1239 GEARRNFSVEVLVPP---SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1295

Query: 757  EESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDPPVHI--VD 810
               +   +  DG   +++  +A +  +G + C         +  F ++V   P  +   +
Sbjct: 1296 ARGDAHHISPDGVLLQVL--QANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAE 1353

Query: 811  PREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPAT 869
                  V    +  + L CE     +P + W KDG   E S  + L   G H   +L A 
Sbjct: 1354 DSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNA- 1411

Query: 870  QPSDGGEFQCVAGDECA-----YFTVTITDVSSWIVYPSGKVYVAAVRLE-RVVLTCELC 923
            Q  D G++ CV  +E       Y    +   S     P G+V V  V+ +    LT E C
Sbjct: 1412 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLE-C 1470

Query: 924  RPWA----EVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDE 975
              WA     +RW KDG+ V  +P+  LQ     R L +   Q+ DSG YLC       ++
Sbjct: 1471 ESWAVPPPTIRWYKDGQPV--TPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED 1528

Query: 976  SASFTVTVTEPPV----------RIIYPRDEVTLIAVT--LECV-----VLMCELSREDA 1018
               F V +  PP+            I  R+E     VT   E V      L C+ +    
Sbjct: 1529 DQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPP 1588

Query: 1019 P-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVT 1073
            P + WY++   +   + + + + G    L +P  + E+ G + C A    G+D   + + 
Sbjct: 1589 PDLTWYREDQPLSAGDEVSVLQGGR--VLQIPLVRAENAGRYSCKASNEVGEDWLHYELL 1646

Query: 1074 VTAPPERIVHPAARSLDLHFGAPGRVELRC-EVAPAGSQVRWYKDGLEVEASDALQLGAE 1132
            V  PP  +        ++   A   V L+C  +      + W ++GL    S  LQ+  +
Sbjct: 1647 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1706

Query: 1133 GPTRTLTLPHAQPEDAGEYVCETRHEAIT----FNVILAEPP-VQFLALETTPSPLCVAP 1187
            G  + L +  A+  DA  Y+C   ++A +    F + +  PP +  L LE   + L    
Sbjct: 1707 G--QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAIL---- 1760

Query: 1188 GEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQ 1246
               V L C++     P V W  + + +  GE  E+        L +  A  + +G+YTC+
Sbjct: 1761 NSSVSLPCDVHAHPNPEVTWYKDSQALSLGE--EVFLLPGTHTLQLGRARLSDSGMYTCE 1818

Query: 1247 SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKD 1305
            +  A G       + V  PP    AP   Q  V    G    L       P   V WYKD
Sbjct: 1819 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1878

Query: 1306 GERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCD----APQDSRIFLVSVEEPLLVK 1361
            G+ L    R Q  + G R  L +Q A+  D G Y C     A +  R F ++V+ P   +
Sbjct: 1879 GQPLVLAQRTQALRGGQR--LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE 1936

Query: 1362 LVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRG 1420
                 T   V  G      C+VS  P   VTWL++   V       +   G    L L  
Sbjct: 1937 NPKTETVSQV-AGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGR--LQLSR 1993

Query: 1421 CQLGDAGTVTLRAGSTATSARLHVRETELLFLR-RLQDVRAE----EGQDVCLEVETGRV 1475
             Q   AGT T  A +T   AR       L+  R R   V  E    EGQ+V L+ E    
Sbjct: 1994 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQ 2053

Query: 1476 GAAGAVRWVRGGQPLPHD--SRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARL 1533
                 V W++ G PL  D    L    DG    L + G+  +D G Y C +H+    A  
Sbjct: 2054 PPPD-VAWLKDGSPLGQDMGPHLRFYLDG--GSLVLKGLRASDAGAYTCVAHNP---AGE 2107

Query: 1534 SVRPRQLRVLRPLEDVTISEGGSATFQLELSQEG--------------VTGEWARGGVQL 1579
              R   + VL P    TI +G   +  L +S+ G              +   W + G+ L
Sbjct: 2108 DARLHTVNVLVP---PTIKQGADGSGTL-VSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 2163

Query: 1580 YPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADS-LRCAARLIVREVPVTIVRGP--- 1635
                +  +H  GH  R  ++ + LAD+G  +  A S    A R    +V V  V  P   
Sbjct: 2164 PLSQRTLLHGSGHTLR--ISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEF 2221

Query: 1636 -HDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPS 1693
             +D+ V  G      CE     L  V+W KDG  L        Q+L     LQL   G  
Sbjct: 2222 QNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLS------QSLEQGPSLQLEAVGAG 2275

Query: 1694 DAGTYSCAVGTARAGPVR----LTVRERT-VAVLSELRSVSAREGDGATFECTVSEV-ET 1747
            D+GTYSC V  + AG  R    LTV E   +    +   +S   G      C      + 
Sbjct: 2276 DSGTYSC-VAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 2334

Query: 1748 TGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG----EVRFQAGPAQSLALLEV 1803
               W   G+ L      R+    +        LR  DAG         AG  +    + V
Sbjct: 2335 NITWHKDGQAL-----TRLENNSR----ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2385

Query: 1804 EALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYEMRSHGPT 1862
            +A P  +    PR    L   + VLE +V +     + W R+G  L      +    G  
Sbjct: 2386 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG-- 2443

Query: 1863 HSLVIHDVRPEDQGTYCCQA 1882
              L +  +   D G Y C A
Sbjct: 2444 RFLQLQALSTADSGDYSCTA 2463



 Score =  225 bits (574), Expect = 3e-58
 Identities = 463/1997 (23%), Positives = 723/1997 (36%), Gaps = 272/1997 (13%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V V       L C  L  P P + W K G    AS  +        HGL +  A   DAG
Sbjct: 1360 VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP--GTHGLQILNAQKEDAG 1417

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
             Y C   N  GEA     V VL PP+   +                 P+   G +     
Sbjct: 1418 QYTCVVTNELGEAVKNYHVEVLIPPSISKD----------------DPLGEVGVKEVKTK 1461

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
              + + L C +  +P PT+ W KDG             + P       G    L+I   +
Sbjct: 1462 VNSTLTLECESWAVPPPTIRWYKDGQ-----------PVTPSSRLQVLGEGRLLQIQPTQ 1510

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV----EPLKCAPKTFW 256
            + DSG Y+C A N  G       + +  PP         A   ++    E      +   
Sbjct: 1511 VSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYRE 1570

Query: 257  VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
            + E   A   C     P P++ W+ E +PL       + +   GG VL++   +A++ G 
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ---GGRVLQIPLVRAENAGR 1627

Query: 317  YVCAARNSAGQTLSAVQLHVKEPR--LRFTRPL-QDVEGREHGIAVLECKVPNSRIPT-A 372
            Y C A N  G+     +L V  P   L  T  L ++V         L+C    + +PT +
Sbjct: 1628 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1687

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            W +      P  + + +E+G V  L +   +  D   Y+C    +  +   +     +  
Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFT---LRV 1742

Query: 433  RLPRKLDVLEGENAVLLVET---------LEAGVEGRWSRDGEELPVICQSSSGHMHALV 483
            ++P ++  L+ E    ++ +              E  W +D + L      S G     +
Sbjct: 1743 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL------SLGE-EVFL 1795

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRV-----KCVKHSPPGPPILAEMFKGHKNTVLLTW 538
            LPG      G    S     T   L       K V+ S   PP   +  +G ++ VL+  
Sbjct: 1796 LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV 1855

Query: 539  K-------PPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
                      +  PE    +  + Q +      Q  ++     +E+    V  +G Y  +
Sbjct: 1856 GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQ--ALRGGQRLEIQEAQVSDKGLYSCK 1913

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFL 649
            +  V+G        F  +  + PT       E V    G   V + D+S +     TW  
Sbjct: 1914 VSNVAGEAVR---TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK 1969

Query: 650  NGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALT 709
            +   ++S+   G V  G             RL L  ++   +G    ++C      A   
Sbjct: 1970 DRMPVESSAVHGVVSRGG------------RLQLSRLQPAQAGT---YTCVAENTQAEAR 2014

Query: 710  IQESPVHILSPQDRVSLT-----FTTSERVVLTCELSRVDFP-ATWYKDGQKV--EESEL 761
                   +++P+ R S           + V L CE      P   W KDG  +  +    
Sbjct: 2015 KDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPH 2074

Query: 762  LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA----FFGVTVQDPPVHIVDPREHVFV 817
            L   +DG    L+L   +  D+G + C     +        V V  PP           +
Sbjct: 2075 LRFYLDGGS--LVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTL 2132

Query: 818  HAITSECVMLACEVDREDAP--VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
             +   E V + C V R   P  V W KDG  +  S   +L   G    L +   Q +D G
Sbjct: 2133 VSRPGELVTMVCPV-RGSPPIHVSWLKDGLPLPLSQRTLLHGSG--HTLRISKVQLADAG 2189

Query: 876  EFQCVA------GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR-PWAE 928
             F CVA       D      V +  V   + + +    V  VR   V L CE    P   
Sbjct: 2190 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQND---VVVVRGSLVELPCEARGVPLPL 2246

Query: 929  VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVT 984
            V W KDGE       LL Q  +    L L AV   DSG Y C    E  +    F +TV 
Sbjct: 2247 VSWMKDGE------PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM 2300

Query: 985  EPPVRIIYPRDEVTLIAVTLEC-VVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGP 1042
            EPP   I    + T +++T    + L+C+      P + W+KDG      +AL    +  
Sbjct: 2301 EPP--HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG------QALTRLENNS 2352

Query: 1043 RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR 1098
            R   VL   +  D G + C     AG     F V V APP  IV P      +   APG+
Sbjct: 2353 RATRVL---RVRDAGLYTCLAESPAGAIEKSFRVRVQAPP-NIVGPRGPRFVVGL-APGQ 2407

Query: 1099 VELRCEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH 1157
            + L C V A    ++ W++DG+ ++     Q    G  R L L      D+G+Y C  R+
Sbjct: 2408 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG--RFLQLQALSTADSGDYSCTARN 2465

Query: 1158 EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQ-E 1215
             A + +V           + + P  + V+  +  +L C+     AP+V W  +  P+   
Sbjct: 2466 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 2525

Query: 1216 GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
                E+  EG  R   IQ      AG Y C +  + G+      ++V EPP   +AP  +
Sbjct: 2526 SPRFEILPEGSLR---IQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP--AIAPSPS 2580

Query: 1276 Q-TRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERL---ASQGRVQLEQAGARQVLRVQG 1330
              T    TP     L    SG   P V W+KDG++L     QG  +L  + A   L +  
Sbjct: 2581 NLTLTAHTPA---LLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---LLLTA 2634

Query: 1331 ARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRC-EVSP 1385
                D+ ++ C    +  +  R++ V+V  P    +  + T  TV         C     
Sbjct: 2635 PGPQDSAQFECVVSNEVGEAHRLYQVTVHVP--PTIADDQTDFTVTMMAPVVLTCHSTGI 2692

Query: 1386 PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD-----AGTVTLRAGSTATSA 1440
            P   V+W + GA +        A+    R+      ++G      AG  T  A ++A  A
Sbjct: 2693 PAPTVSWSKAGAQLG-------ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 2745

Query: 1441 RLHVRETELL--FLRRLQD-VRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLS 1497
              HV  T      ++ L   VRA   ++V L  E   +     + W + G  +       
Sbjct: 2746 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI-PRPTITWQKEGLNVATGVSTQ 2804

Query: 1498 MAQDGHIHRLFIHGVILADQGTYGCESHHDRTLA----RLSVRPRQLRVLRPLEDVTISE 1553
            +   G   +L I      D G Y C + +    A    RL V+   + +   L D++ +E
Sbjct: 2805 VLPGG---QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLPDLSTTE 2860

Query: 1554 G----------GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            G          GS    +   ++G     A G   + P  +           L++  L  
Sbjct: 2861 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-----------LLVKNLEG 2909

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
             D+G  + TA++    AR   R V +TI+  P           T   + S  L D  W +
Sbjct: 2910 QDAGTYTCTAENAVGRAR---RRVHLTILVLP--------VFTTLPGDRSLRLGDRLWLR 2958

Query: 1664 DGNALTPSPRL------RLQALGTRR-----LLQLRRCGPSDAGTYSC----AVGTARAG 1708
                 +P+PR+      R    G         LQ       D+GTY C     VG  +A 
Sbjct: 2959 CAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV 3018

Query: 1709 PVRLTVRERTVAVLSELRSVSAREGDGATFECTV-SEVETTGRWELGGRPLRPGARVRIR 1767
               + V+E  V        +    G     +C V  +      W   G PLR      +R
Sbjct: 3019 SF-VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGS---HLR 3074

Query: 1768 QEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVEALPLQMCRHPPREKTVLVG 1823
             + +   L +     +DAG  +  A    G A+ + +L +++ P+      P++ TV  G
Sbjct: 3075 HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVE--PQDMTVRSG 3132

Query: 1824 RRAVLEV-TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
                L           + WL+ G  L    +       P  SL + +V   D GTY C A
Sbjct: 3133 DDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL---PDGSLWLENVETGDAGTYDCVA 3189

Query: 1883 ----GQDSTHTRLLVEG 1895
                G  +    L+V G
Sbjct: 3190 HNLLGSATARAFLVVRG 3206



 Score =  172 bits (435), Expect = 4e-42
 Identities = 315/1337 (23%), Positives = 507/1337 (37%), Gaps = 143/1337 (10%)

Query: 652  EELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQ 711
            E  K  +P   V PG    ++++ G   R+    V  +     V FS  G Q        
Sbjct: 250  EWTKDRQP---VLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV 306

Query: 712  ESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRK 770
             +P  I    +   +       V L CE   V  P  TW+KDG  +  S  +V    GR+
Sbjct: 307  HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ 366

Query: 771  HRLILPEAKVQDSGEFECR-TEGVSAFFGVTVQD----PPVHIVDPREHVFVHAITSECV 825
              L L  A+  D+G + C+ +  V A    T  D    P +     R +V V A+    V
Sbjct: 367  --LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV-VKAVAGRPV 423

Query: 826  MLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA--- 881
             L C      +P + W+ +G  V ES+   LE +G   RL  P    S  G + CVA   
Sbjct: 424  ALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASS--GLYSCVASSP 481

Query: 882  -GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWTKDGEEVV 939
             G+    ++V +  V   ++   G   V  +  + + L C+    P   ++W ++G    
Sbjct: 482  AGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAE 540

Query: 940  ESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS------------FTVTVTEPP 987
            E   + +  + T   L +  V+L+ SG + C+  +E+ +            +   V E P
Sbjct: 541  ELAGVQVASQGTT--LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 598

Query: 988  V-RIIYPRDEVTLIAVTLECVVLMCELSREDAPV--RWYKDGLEVEESEALVLERDGPRC 1044
            + +  +  +  +      +  V     +    P+   W   G    E   + +    P  
Sbjct: 599  IGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP- 657

Query: 1045 RLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVE 1100
             L +      D G + C A    G+      + V  PP   + P   +  +   A   +E
Sbjct: 658  PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN--IEPGPVNKAVLENASVTLE 715

Query: 1101 LRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA- 1159
                  P    V W+K    V +   + +  +G  R L +  AQ  DAG Y C   + A 
Sbjct: 716  CLASGVPP-PDVSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYRCVASNVAG 772

Query: 1160 ---ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQE 1215
               + + + +  PP +     + P P+ V    PV L+C  + A +P ++W  +G PV  
Sbjct: 773  STELRYGLRVNVPP-RITLPPSLPGPVLV--NTPVRLTCNATGAPSPTLMWLKDGNPVSP 829

Query: 1216 G--EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPE 1273
                GL++   G  RVL + +A  + +G Y+C + +A G       +QV  PP   +  E
Sbjct: 830  AGTPGLQVFPGG--RVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP--SILGE 885

Query: 1274 AAQTRVRSTPGGDLELVVHLSGPGGPV-RWYKDGERLASQGRVQLEQAGARQVLRVQGAR 1332
                 V +     LE   H   P  PV  W+KDG  L  +  V L  +  + +L+V  A 
Sbjct: 886  ELNVSVVANESVALECQSHAMPP--PVLSWWKDGRPLEPRPGVHL--SADKALLQVDRAD 941

Query: 1333 SGDAGEYLCD----APQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPD 1387
              DAG Y C+    A +  + + ++V    +  L  E   LTV EG   +  CE    P 
Sbjct: 942  VWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPL-RESHTLTVREGHPTSLSCECRGVPF 1000

Query: 1388 ADVTWLRNGAVVTPGPQVEMAQ-NGSSRILTLRGCQLGDAGTVTLR----AGSTATSARL 1442
              ++W ++G  + PG    +   +   R+L L   QL   GT T       G+++   +L
Sbjct: 1001 PKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQL 1059

Query: 1443 HVRETELLFLRRLQDVRAEEGQDVCLEVETGRVG-AAGAVRWVRGGQPLPHDSRLSMAQD 1501
             V     +   R    +    QD    +E    G     V W R GQP+  +  L +   
Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ 1119

Query: 1502 GHIHRLFIHGVILADQGTYGCESHHDRTLAR------LSVRPRQLRVLRPLEDVTISEGG 1555
            G    L +     A  G Y C + +    A       + V P  +  L PL ++T +   
Sbjct: 1120 G--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHS 1177

Query: 1556 SATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTAD 1614
              T   E +        W RG   + PG   ++ + G    L +      DSG  S  A 
Sbjct: 1178 PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG--WMLKMTQTQEQDSGLYSCLAS 1235

Query: 1615 SLRCAARLIVREVPVTIVRGP----HDLE----VTEGDTATFECELS-QALADVTWEKDG 1665
            +    AR   R   V ++  P     DLE    V +G TA   C ++      +TW KDG
Sbjct: 1236 NEAGEAR---RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDG 1292

Query: 1666 NALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSEL 1725
              L       +   G   LLQ+ +   S AG YSC    A    V    +   ++VL   
Sbjct: 1293 RPLARGDAHHISPDGV--LLQVLQANLSSAGHYSCIAANA----VGEKTKHFQLSVLLAP 1346

Query: 1726 RSVSAREGDGATFECTVSEVETTG-------------RWELGGRPLRPGARVRIRQEGKK 1772
              +   E D A  E TV+                    W   G P      +++      
Sbjct: 1347 TILGGAE-DSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP--GT 1403

Query: 1773 HILVLSELRAEDAGE----VRFQAGPAQSLALLEVEALPLQMCRHPP------REKTVLV 1822
            H L +   + EDAG+    V  + G A     +EV  +P  + +  P      +E    V
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV-LIPPSISKDDPLGEVGVKEVKTKV 1462

Query: 1823 GRRAVLEV-TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC- 1880
                 LE  + +     + W ++G  + P  + ++   G    L I   +  D G Y C 
Sbjct: 1463 NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSDSGRYLCV 1520

Query: 1881 ---QAGQDSTHTRLLVE 1894
                AG+D     +L++
Sbjct: 1521 ATNVAGEDDQDFNVLIQ 1537



 Score =  167 bits (424), Expect = 7e-41
 Identities = 277/1182 (23%), Positives = 433/1182 (36%), Gaps = 165/1182 (13%)

Query: 819  AITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQ 878
            ++T EC  LA  V   D  V W+K  Q V     V +  +G  R L +   Q SD G ++
Sbjct: 711  SVTLEC--LASGVPPPD--VSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYR 764

Query: 879  CVAGDECAYFTVTI---TDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWTKD 934
            CVA +      +      +V   I  P        V    V LTC     P   + W KD
Sbjct: 765  CVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP-VRLTCNATGAPSPTLMWLKD 823

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRI 990
            G  V  +    LQ     R L L + +  DSG Y C     + ++     + V  PP  +
Sbjct: 824  GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL 883

Query: 991  IYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLVLP 1049
                +E+ +  V  E V L C+      PV  W+KDG  +E    + L  D  +  L + 
Sbjct: 884  ---GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD--KALLQVD 938

Query: 1050 AAQPEDGGEFVCD----AGDDSAFFTVTVTAPPERIVHPAARS--LDLHFGAPGRVELRC 1103
             A   D G + C+    AG     + + V   P   V P   S  L +  G P  +   C
Sbjct: 939  RADVWDAGHYTCEALNQAGRSEKHYNLNVWVAP---VFPLRESHTLTVREGHPTSLSCEC 995

Query: 1104 EVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFN 1163
               P   ++ W KDG  +    A         R L L  AQ    G Y CE  +      
Sbjct: 996  RGVPF-PKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN------ 1048

Query: 1164 VILAEPPVQFLALETTPSPLCVAPGEPV---------VLSCELSRAGAP---VVWSHNGR 1211
              +     Q L LE    P    P EP          V + E +  G P   V W  +G+
Sbjct: 1049 --VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 1106

Query: 1212 PVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVA 1271
            PV    GL+L  +G  + L ++ A  AH G Y+C +    G     F + V  PP  ++ 
Sbjct: 1107 PVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP-ELIG 1163

Query: 1272 PEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
                 T + +     L L+    G P   +RW++ GE   S G      AG   +L++  
Sbjct: 1164 DLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR-GEEPVSPGEDTYLLAGG-WMLKMTQ 1221

Query: 1331 ARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS-P 1385
             +  D+G Y C    +A +  R F V V  P  ++       + V +G  A   C V+  
Sbjct: 1222 TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGH 1281

Query: 1386 PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
            P   +TW ++G  +  G    ++ +G   +L +    L  AG  +  A +       H +
Sbjct: 1282 PQPKLTWFKDGRPLARGDAHHISPDGV--LLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 1339

Query: 1446 ETELLFLRRLQDVRAEEGQDVCLEVET-------GRVGAAGAVRWVRGGQPLPHDSRLSM 1498
             + LL    L        ++V + V              +  + W++ G P      + +
Sbjct: 1340 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 1399

Query: 1499 AQDGHIHRLFIHGVILADQGTYGC----------ESHHDRTLARLSVRPRQLRVLRPLED 1548
                  H L I      D G Y C          +++H   L      P  +    PL +
Sbjct: 1400 LPG--THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGE 1452

Query: 1549 VTISE---GGSATFQLELSQEGV---TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
            V + E     ++T  LE     V   T  W + G  + P  +  +  +G    L +    
Sbjct: 1453 VGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQ 1510

Query: 1603 LADSG---CVSFT---------------------ADSLRCAARLIVREVP----VTIVRG 1634
            ++DSG   CV+                             A  ++ RE      VT  R 
Sbjct: 1511 VSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR- 1569

Query: 1635 PHDLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPS 1693
                E+ E + A   C+ +     D+TW ++   L+    + +   G  R+LQ+      
Sbjct: 1570 ----EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRAE 1623

Query: 1694 DAGTYSCAVGT------------ARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC- 1740
            +AG YSC                    PV L   E  V        V+       + +C 
Sbjct: 1624 NAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELV------EEVTVNASSTVSLQCP 1677

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
             +     T  W   G P  P  R+++ ++G+  +L +S     DA         QAG A+
Sbjct: 1678 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1735

Query: 1797 SLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYE 1855
             L  L V+ +P ++      + T ++     L   V +     V W ++   L  G+  E
Sbjct: 1736 KLFTLRVQ-VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE--E 1792

Query: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQ----AGQDSTHTRLLV 1893
            +     TH+L +   R  D G Y C+    AG+D    +L V
Sbjct: 1793 VFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 1834



 Score =  143 bits (361), Expect = 1e-33
 Identities = 259/1094 (23%), Positives = 412/1094 (37%), Gaps = 168/1094 (15%)

Query: 15   LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
            + F   V VV G+  EL C   G P P+V W K G+ L +      P+      L L A 
Sbjct: 2219 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS------LQLEAV 2272

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
               D+G Y C A + AGEA     +TV+EPP  +   QP E  L                
Sbjct: 2273 GAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTP-------------- 2318

Query: 135  RSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLAL 194
                   GA + L C A G P+P + W KDG AL  + ++S                 A 
Sbjct: 2319 -------GAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR----------------AT 2355

Query: 195  RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKT 254
            R+L  R+ D+G+Y C A +  G  +    ++V  PP             +V P    P+ 
Sbjct: 2356 RVL--RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPN------------IVGPR--GPRF 2399

Query: 255  FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
                        C V  +P P+I WH +G  L  D     + +R  G  L++      D 
Sbjct: 2400 VVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQED-AHTQFPER--GRFLQLQALSTADS 2456

Query: 315  GLYVCAARNSAGQTLSAVQLHVKE-PRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW 373
            G Y C ARN+AG T  A ++ +   P +R   P  +V   +   A+L C+      P   
Sbjct: 2457 GDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQ--TALLPCQADGVPAPLVS 2514

Query: 374  FREDQRLLPCR--KYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTV-K 427
            +R+D+  L  R  ++E + EG++R   I  + A D G YLC      G  R   ++ V +
Sbjct: 2515 WRKDRVPLDPRSPRFEILPEGSLR---IQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE 2571

Query: 428  GPILKRLPRKLDVLEGENAVLLVETLEAGVE-GRWSRDGEELPVICQSSSGHM---HALV 483
             P +   P  L +     A+L  E   +      W +DG++L    Q  +  +   +AL+
Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2631

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNT-----VLLTW 538
            L     +D+ +    + N         +   H    PP +A+       T     VL   
Sbjct: 2632 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIADDQTDFTVTMMAPVVLTCH 2688

Query: 539  KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVP-SEGDYRFRICTVSG 597
                PAP     +     ++G+      + +  +GA+E+ G  +P   G Y    C+   
Sbjct: 2689 STGIPAPTVS--WSKAGAQLGARG--SGYRVSPSGALEI-GQALPIHAGRY---TCSARN 2740

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELK 655
                 H     +    P  + +  +  V+    E+ +   + S I +   TW   G  + 
Sbjct: 2741 SAGVAHKHVFLTVQASPVVKPLPSV--VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVA 2798

Query: 656  SNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSG---ALVGFSCPGVQDSAALTIQE 712
            +      +  G LR            I HA   +D+G    +   S         L +Q 
Sbjct: 2799 TGVSTQVLPGGQLR------------IAHA-SPEDAGNYLCIAKNSAGSAMGKTRLVVQV 2845

Query: 713  SPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESE-LLVVKMDGRK 770
             PV      D   L+ T      L C+      P  TW KDGQ V  +E    ++  G  
Sbjct: 2846 PPVIENGLPD---LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG-- 2900

Query: 771  HRLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVM 826
              L++   + QD+G + C  E           +T+   PV    P +         + + 
Sbjct: 2901 -ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR---SLRLGDRLW 2956

Query: 827  LACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC-----V 880
            L C       P + W  + + V E    V E +G    L   A    D G + C     V
Sbjct: 2957 LRCAARGSPTPRIGWTVNDRPVTEG---VSEQDG-GSTLQRAAVSREDSGTYVCWAENRV 3012

Query: 881  AGDECAYFT------VTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKD 934
               +   F       V   +  S++V P G     +++L+ VV       P  ++ W KD
Sbjct: 3013 GRTQAVSFVHVKEAPVLQGEAFSYLVEPVG----GSIQLDCVVRG----DPVPDIHWIKD 3064

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE----SASFTVTVTEPPVRI 990
            G  +  S    L+ +     L +   + +D+G Y C  ++E         + +   PV  
Sbjct: 3065 GLPLRGSH---LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQ 3121

Query: 991  IYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLP 1049
            + P+D   +   + + V L C+ + E  P + W + G  +  S  L    DG    L L 
Sbjct: 3122 VEPQD---MTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG---SLWLE 3175

Query: 1050 AAQPEDGGEFVCDA 1063
              +  D G + C A
Sbjct: 3176 NVETGDAGTYDCVA 3189



 Score =  141 bits (355), Expect = 7e-33
 Identities = 285/1221 (23%), Positives = 452/1221 (37%), Gaps = 140/1221 (11%)

Query: 773  LILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLA 828
            L L      DSG++EC+        S    + V  PP    D R+   V  +  + + L 
Sbjct: 59   LFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRK-ANVSGMAGQSLTLE 117

Query: 829  CEVDREDAP-VRWYKDGQEVEE-------SDFVVLENEGPHR------RLVLPATQPSDG 874
            C+ +    P + W KD Q V            +     G HR       L  P  QP   
Sbjct: 118  CDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRS 177

Query: 875  GEFQCVAGDECAYFTVTITDVSSWIVYPSGKVY----------------VAAVRLERVVL 918
            G     AG            ++ +  +P+   +                V  +    V L
Sbjct: 178  GRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVEL 237

Query: 919  TCELCR-PWAEVRWTKDGEEVVES-PALLLQKEDTVRRLVLPAVQLEDSGEYLC----EI 972
             C     P  +V WTKD + V+   P L +Q++  V R+      + D G Y C      
Sbjct: 238  QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT--GSHVGDEGRYQCVAFSPA 295

Query: 973  DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV-LMCELSREDAP-VRWYKDGLEVE 1030
              ++  F + V  PP   I+  +E   +AV  + +V L+CE      P + W+KDG  + 
Sbjct: 296  GQQARDFQLRVHAPPT--IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLP 353

Query: 1031 ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTAPPERIVHPAA 1086
             S  +V  R G +  L L  AQ  D G + C A    G       + V  PP  I     
Sbjct: 354  TSTKVVYTRGGRQ--LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT-IEGAGG 410

Query: 1087 RSLDLHFGAPGRVELRCEVAPAGSQ-VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQP 1145
            R   +   A   V L C      S  + W+ +GL V  S+  +L  +G    L  P    
Sbjct: 411  RPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA- 469

Query: 1146 EDAGEYVCETRH---EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGA 1202
              +G Y C       EA+    +  + P Q L  E       +  G+P+ L C+ S +  
Sbjct: 470  -SSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV-GQPLELPCQASGSPV 527

Query: 1203 PVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQ 1261
            P + W  NGRP +E  G+++ ++G    L I      H+GL+ CQ+    G       V 
Sbjct: 528  PTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 585

Query: 1262 V-AEPPVRVVAPEAAQ----TRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQ 1316
            V  E    V+     Q        S+     +  VH      P     +G    S G + 
Sbjct: 586  VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEG--WCSPGSLW 643

Query: 1317 LEQAGARQV------LRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPL- 1369
             E  G          L+++     D G Y C A   +      V   +LV    E  P+ 
Sbjct: 644  GEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN 703

Query: 1370 -TVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAG 1427
              V E    T  C  S  P  DV+W +    V+    V ++ +G  R+L +   QL DAG
Sbjct: 704  KAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAG 761

Query: 1428 TVTLRAGSTA--TSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGA-AGAVRWV 1484
            +    A + A  T  R  +R      +     +      +  + +     GA +  + W+
Sbjct: 762  SYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWL 821

Query: 1485 RGGQPLPHDSR--LSMAQDGHIHRLFIHGVILADQGTYGC-------ESHHDRTLARLSV 1535
            + G P+       L +   G +  L +     +D G Y C       E   D  L ++ +
Sbjct: 822  KDGNPVSPAGTPGLQVFPGGRV--LTLASARASDSGRYSCVAVSAVGEDRQDVVL-QVHM 878

Query: 1536 RPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTG---EWARGGVQLYPGPKCHIHSDGH 1592
             P  L      E++ +S   + +  LE     +      W + G  L P P  H+ +D  
Sbjct: 879  PPSILG-----EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD-- 931

Query: 1593 RHRLVLNGLGLADSGCVSFTADSLRCAAR------LIVREVPVTIVRGPHDLEVTEGDTA 1646
            +  L ++   + D+G   +T ++L  A R      L V   PV  +R  H L V EG   
Sbjct: 932  KALLQVDRADVWDAG--HYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPT 989

Query: 1647 TFECEL-SQALADVTWEKDGNALTPSPRLRLQAL-GTRRLLQLRRCGPSDAGTYSC---- 1700
            +  CE        ++W KDG  L P     LQ +    RLL L +   +  GTY+C    
Sbjct: 990  SLSCECRGVPFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN 1048

Query: 1701 AVGTARAG-PVRLTVRERTVAVLSELRSVSAREGDGATFECTVS-EVETTGRWELGGRPL 1758
             VG +     + + V  +          VS  +   AT EC  + +   T  WE  G+P+
Sbjct: 1049 VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV 1108

Query: 1759 RPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ------AGPAQSLALLEVEALPLQMCR 1812
                 ++++ +G+     L   RA+ A   R+       AG A+    L V  +P ++  
Sbjct: 1109 GAELGLQLQNQGQS----LHVERAQAAHTGRYSCVAENLAGRAERKFELSV-LVPPELIG 1163

Query: 1813 HPPREKTVLVGRRAVLEVTVSRSG---GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHD 1869
                   +     + L +     G     + W R    + PG+   + + G    L +  
Sbjct: 1164 DLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG--WMLKMTQ 1221

Query: 1870 VRPEDQGTYCCQAGQDSTHTR 1890
             + +D G Y C A  ++   R
Sbjct: 1222 TQEQDSGLYSCLASNEAGEAR 1242



 Score =  127 bits (319), Expect = 1e-28
 Identities = 137/470 (29%), Positives = 187/470 (39%), Gaps = 84/470 (17%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA---SERLSFPADGAEH 67
            PP          V   A   L C   G P P V W K G QL A     R+S P+   E 
Sbjct: 2665 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVS-PSGALEI 2723

Query: 68   GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            G     ALP  AG Y C ARN+AG A+    +TV        +  P  +PLPS       
Sbjct: 2724 G----QALPIHAGRYTCSARNSAGVAHKHVFLTV--------QASPVVKPLPS------- 2764

Query: 128  PVFLTGPRSQWVLRGA---EVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA 184
                       V+R     EV+L C A G+P PT+ W+K+G+    V       + PG  
Sbjct: 2765 -----------VVRAVAEEEVLLPCEASGIPRPTITWQKEGL---NVATGVSTQVLPGG- 2809

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPV 244
                     LRI  A   D+G Y+C A+N+ G A     L V  PP      PD +    
Sbjct: 2810 --------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLS---- 2857

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVL 304
                          EG HA   C   G PEP I W  +G+P+     +   +   G  ++
Sbjct: 2858 ------------TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQP-SGELLV 2904

Query: 305  KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV 364
            K L  + +D G Y C A N+ G+    V L +    +  T P  D   R      L C  
Sbjct: 2905 KNL--EGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLP-GDRSLRLGDRLWLRCAA 2961

Query: 365  PNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC--EMR-GRVRTV 421
              S  P   +  + R +     EQ    T++R  + R   +D G Y+C  E R GR + V
Sbjct: 2962 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVGRTQAV 3018

Query: 422  ANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVI 471
            + V VK         +  VL+GE    LVE +   ++      G+ +P I
Sbjct: 3019 SFVHVK---------EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDI 3059



 Score =  117 bits (292), Expect = 1e-25
 Identities = 119/430 (27%), Positives = 166/430 (38%), Gaps = 62/430 (14%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP     P  + + +   A L C   G P P+VVW K GQ+L    +         + LL
Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2631

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            LTA  P D+  + C   N  GEA+    VTV  PP    +       + +P         
Sbjct: 2632 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP--------- 2682

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
                          VVLTC + G+P PT+ W K G  L      S + + P         
Sbjct: 2683 --------------VVLTCHSTGIPAPTVSWSKAGAQLGA--RGSGYRVSP--------- 2717

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
            S AL I  A    +G Y C ARN+ G A     L V               +PVV+PL  
Sbjct: 2718 SGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ-------------ASPVVKPL-- 2762

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
             P        +     C   G P P I W  EG   L     +  +   GG  L++ +  
Sbjct: 2763 -PSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPGG-QLRIAHAS 2817

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP 370
             +D G Y+C A+NSAG  +   +L V+ P +     L D+   E   A L CK   S  P
Sbjct: 2818 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLPDLSTTEGSHAFLPCKARGSPEP 2876

Query: 371  T-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVANVTV 426
               W ++ Q +        I+      L++  L+  D G Y C      GR R   ++T+
Sbjct: 2877 NITWDKDGQPVSGAEGKFTIQPS--GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2934

Query: 427  KG-PILKRLP 435
               P+   LP
Sbjct: 2935 LVLPVFTTLP 2944



 Score =  111 bits (278), Expect = 6e-24
 Identities = 127/472 (26%), Positives = 177/472 (37%), Gaps = 69/472 (14%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  L     V VV+     L+C     PPPV+ W K G+ L     +   AD A   L 
Sbjct: 879  PPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL--LQ 936

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +  A   DAG Y C A N AG +     + V                         APVF
Sbjct: 937  VDRADVWDAGHYTCEALNQAGRSEKHYNLNVWV-----------------------APVF 973

Query: 131  -LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
             L    +  V  G    L+C   G+P P + W KDG  L            PG       
Sbjct: 974  PLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL------------PGEGAGLQH 1021

Query: 190  ASLALRIL---AARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
             S   R+L    A+L   G Y C   N  G++     L+VH PP+   A P E P  V  
Sbjct: 1022 VSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI--AGPREPPTQVS- 1078

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
                      V +   A   C   GKP P + W  +G+P+      L  + ++ G  L V
Sbjct: 1079 ----------VVQDGVATLECNATGKPPPTVTWERDGQPV---GAELGLQLQNQGQSLHV 1125

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP--RLRFTRPLQDVEGREHGIAVLECKV 364
               QA   G Y C A N AG+     +L V  P   +    PL ++    H    L C+ 
Sbjct: 1126 ERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEA 1185

Query: 365  PNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRT 420
                 P   WFR ++ + P      +  G + ++   + +  D G+Y C      G  R 
Sbjct: 1186 MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMT--QTQEQDSGLYSCLASNEAGEARR 1243

Query: 421  VANVTVKGPIL---KRLPRKLDVLEGENAVLLVE-TLEAGVEGRWSRDGEEL 468
              +V V  P     + L   + VL+G+ A L+   T     +  W +DG  L
Sbjct: 1244 NFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1295



 Score =  107 bits (267), Expect = 1e-22
 Identities = 252/1068 (23%), Positives = 390/1068 (36%), Gaps = 163/1068 (15%)

Query: 925  PWAEVRWTK--DGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFT-- 980
            P  +V W K    E +   P + + +E +   L L +V   DSG+Y C+  +E  S +  
Sbjct: 30   PKPQVTWRKGPSSEPLHGQPGVAVLEEGS---LFLASVSPADSGDYECQATNEVGSTSRR 86

Query: 981  ---VTVTEPPVRIIYPRDEVTLIA---VTLEC---------VVLMCELSREDAPVRWYKD 1025
               V    P +R    +  V+ +A   +TLEC         +V + +      P+ W   
Sbjct: 87   AKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 146

Query: 1026 GLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDS----------AFFTVTVT 1075
            G ++   +            L  P  QP   G     AG  +          A F    T
Sbjct: 147  GWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPT 206

Query: 1076 -------APPERIVHPAARSLDLHFGAPGRVELRCEVAPAGS-QVRWYKDGLEV-EASDA 1126
                   APP  +   AA+ +    GA   VEL+C  +   + QV W KD   V      
Sbjct: 207  PHAFSPPAPPSVLGAGAAQEVLGLAGAD--VELQCWTSGVPTPQVEWTKDRQPVLPGGPH 264

Query: 1127 LQLGAEGPTRTLTLPHAQPEDAGEYVC----ETRHEAITFNVILAEPPVQFLALETTPSP 1182
            LQ+  +G    +T  H    D G Y C        +A  F + +  PP  + + ET    
Sbjct: 265  LQVQEDGQVLRITGSHV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNET--GE 320

Query: 1183 LCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAG 1241
            + V     V L CE      P + W  +G  +     + ++  G R+ L +  A  + AG
Sbjct: 321  VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV-VYTRGGRQ-LQLGRAQSSDAG 378

Query: 1242 LYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPV 1300
            +YTC++  A GA   +  + V  PP  +         V++  G  + L     G P   +
Sbjct: 379  VYTCKASNAVGAAEKATRLDVYVPPT-IEGAGGRPYVVKAVAGRPVALECVARGHPSPTL 437

Query: 1301 RWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC--DAPQDSRI--FLVSVEE 1356
             W+ +G  +A     +LE  G+  VLR++      +G Y C   +P    +  + V V+ 
Sbjct: 438  SWHHEGLPVAESNESRLETDGS--VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 495

Query: 1357 PLLVKLVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRI 1415
            P  + +   L  +T   G      C+ S  P   + WL+NG        V++A  G++  
Sbjct: 496  PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT-- 553

Query: 1416 LTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRV 1475
            L +   +L  +G    +A + A +A   V  +          V  E    V LEV  G+ 
Sbjct: 554  LHIDHVELDHSGLFACQATNEAGTAGAEVEVS----------VHGEWAPGV-LEVPIGQ- 601

Query: 1476 GAAGAVRWVRGGQPLPHDSRLSMAQDGHIHR----------------------------- 1506
                   W        H S    A D  +HR                             
Sbjct: 602  -----YHW-----GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV 651

Query: 1507 -------LFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRP--LEDVTISEG--G 1555
                   L I  V L D+G Y C +     LA  S R   L+VL P  +E   +++    
Sbjct: 652  AYSLPPPLQIEKVDLRDEGIYTCAA---TNLAGESKREVALKVLVPPNIEPGPVNKAVLE 708

Query: 1556 SATFQLELSQEGVTG---EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFT 1612
            +A+  LE    GV      W +G   +       +  DG   R  +    L+D+G     
Sbjct: 709  NASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLR--IEQAQLSDAGSYRCV 766

Query: 1613 ADSLRCAARL---IVREVPVTIVRGPH-DLEVTEGDTATFECELSQALA-DVTWEKDGNA 1667
            A ++  +  L   +   VP  I   P     V         C  + A +  + W KDGN 
Sbjct: 767  ASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP 826

Query: 1668 LTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC----AVGTARAGPVRLTVRERTVAVLS 1723
            ++P+    LQ     R+L L     SD+G YSC    AVG  R   V         ++L 
Sbjct: 827  VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILG 884

Query: 1724 ELRSVSAREGDGATFECTVSEV-ETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRA 1782
            E  +VS    +    EC    +      W   GRPL P  R  +     K +L +     
Sbjct: 885  EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP--RPGVHLSADKALLQVDRADV 942

Query: 1783 EDAG----EVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG- 1837
             DAG    E   QAG ++    L V   P+     P RE   L  R            G 
Sbjct: 943  WDAGHYTCEALNQAGRSEKHYNLNVWVAPV----FPLRESHTLTVREGHPTSLSCECRGV 998

Query: 1838 ---HVCWLREGAELCPGDKYEMRSHGPTHSLV-IHDVRPEDQGTYCCQ 1881
                + W ++G  L PG+   ++       L+ +   +   +GTY C+
Sbjct: 999  PFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045



 Score =  105 bits (262), Expect = 4e-22
 Identities = 107/404 (26%), Positives = 148/404 (36%), Gaps = 63/404 (15%)

Query: 24  VSGAEAELKCVVLGEPPPVVVWEKGGQQ-LAASERLSFPADGAEHGLLLTAALPTDAGVY 82
           ++GA+ EL+C   G P P V W K  Q  L     L    DG    L +T +   D G Y
Sbjct: 230 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDG--QVLRITGSHVGDEGRY 287

Query: 83  VCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRG 142
            C A + AG+      + V  PP                GS E   V         V+  
Sbjct: 288 QCVAFSPAGQQARDFQLRVHAPPT-------------IWGSNETGEVA--------VMED 326

Query: 143 AEVVLTCRAGGLPEPTLYWEKDGMALDE----VWDSSHFALQPGRAEDGPGASLALRILA 198
             V L C A G+P P + W KDG  L      V+      LQ GRA+             
Sbjct: 327 HLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS----------- 375

Query: 199 ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN 258
               D+GVY C A NA G A+    L V+ P             P +E     P      
Sbjct: 376 ----DAGVYTCKASNAVGAAEKATRLDVYVP-------------PTIEGAGGRPYVVKAV 418

Query: 259 EGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYV 318
            G+     C   G P P + WH EG P+       +  D   G VL++        GLY 
Sbjct: 419 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETD---GSVLRLESPGEASSGLYS 475

Query: 319 CAARNSAGQTLSAVQLHVK-EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPT-AWFRE 376
           C A + AG+ +    + V+  P+L     L  V         L C+   S +PT  W + 
Sbjct: 476 CVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN 535

Query: 377 DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420
            +        +   +GT   L I  ++ D  G++ C+      T
Sbjct: 536 GRPAEELAGVQVASQGTT--LHIDHVELDHSGLFACQATNEAGT 577



 Score =  101 bits (252), Expect = 6e-21
 Identities = 208/827 (25%), Positives = 310/827 (37%), Gaps = 104/827 (12%)

Query: 1137 TLTLPHAQPEDAGEYVCETRHEAITFN-----VILAEPPVQFLALETTPSPL-------- 1183
            +L L    P D+G+Y C+  +E  + +     V+   P ++    +   S +        
Sbjct: 58   SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 117

Query: 1184 CVAPGEPV---VLSCELSRAGAPVVWSHNGRPVQEGE--GLELHAEGPRRVLCIQAAGPA 1238
            C A G PV   V   +    G P+ W+  G  +  G+  G  L  EG  + L      P 
Sbjct: 118  CDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG--QSLHFPRIQPG 175

Query: 1239 HAGLYTCQSGA-----APGAPSLSFTVQVAEP-------PVRVVAPEAAQTRVRSTPGGD 1286
             +G    Q+G      AP    L+   Q   P       P  V+   AAQ  V    G D
Sbjct: 176  RSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQ-EVLGLAGAD 234

Query: 1287 LELVVHLSG-PGGPVRWYKDGERLASQG-RVQLEQAGARQVLRVQGARSGDAGEYLC--- 1341
            +EL    SG P   V W KD + +   G  +Q+++ G  QVLR+ G+  GD G Y C   
Sbjct: 235  VELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDG--QVLRITGSHVGDEGRYQCVAF 292

Query: 1342 -DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVV 1399
              A Q +R F + V  P  +   +E   + V E       CE    P  ++TW ++GA++
Sbjct: 293  SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 352

Query: 1400 TPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGST------ATSARLHVRETELLFLR 1453
                +V   + G  R L L   Q  DAG  T +A +       AT   ++V  T      
Sbjct: 353  PTSTKVVYTRGG--RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 410

Query: 1454 RLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVI 1513
            R   V+A  G+ V LE    R   +  + W   G P+   +   +  DG + RL   G  
Sbjct: 411  RPYVVKAVAGRPVALEC-VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGE- 468

Query: 1514 LADQGTYGC--ESHHDRTLARLSVR---PRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
             A  G Y C   S     + + SV    P QL V   L  VT   G       + S   V
Sbjct: 469  -ASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPV 527

Query: 1569 -TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREV 1627
             T +W + G          + S G    L ++ + L  SG  +  A +    A   V EV
Sbjct: 528  PTIQWLQNGRPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGTAGAEV-EV 584

Query: 1628 PVTIVRGPHDLEVTEGD-------TATFECELSQAL-----------ADVTWEKDGNALT 1669
             V     P  LEV  G         ++F       +               W   G +L 
Sbjct: 585  SVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG-SLW 643

Query: 1670 PSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELR--- 1726
              P     A      LQ+ +    D G Y+CA  T  AG  +   RE  + VL       
Sbjct: 644  GEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCA-ATNLAGESK---REVALKVLVPPNIEP 699

Query: 1727 ---SVSAREGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKHILVLSELRA 1782
               + +  E    T EC  S V      W  G +P+     V +  +G+  +L + + + 
Sbjct: 700  GPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQL 757

Query: 1783 EDAGEVRF----QAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG- 1837
             DAG  R      AG  +    L V  +P ++   P     VLV     + +T + +G  
Sbjct: 758  SDAGSYRCVASNVAGSTELRYGLRVN-VPPRITLPPSLPGPVLV--NTPVRLTCNATGAP 814

Query: 1838 --HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
               + WL++G  + P     ++       L +   R  D G Y C A
Sbjct: 815  SPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVA 861



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 102/410 (24%), Positives = 148/410 (36%), Gaps = 55/410 (13%)

Query: 33  CVVLGEPPPVVVWEKGGQQLAASERLSFPADGA---EHGLLLTAALPTDAGVYVCRARNA 89
           C   G P P V W KG     +SE L      A   E  L L +  P D+G Y C+A N 
Sbjct: 24  CGTHGTPKPQVTWRKG----PSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNE 79

Query: 90  AGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTC 149
            G     A + V  PP+                  +G    ++G      + G  + L C
Sbjct: 80  VGSTSRRAKLVVYVPPSI---------------REDGRKANVSG------MAGQSLTLEC 118

Query: 150 RAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVC 209
            A G P P + W KD   +      + +    G  + G            RL D G  + 
Sbjct: 119 DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG----------GHRLLDEGQSLH 168

Query: 210 HARNAHGH-----AQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN------ 258
             R   G      AQAG   Q   P  +  A  ++ P P        P            
Sbjct: 169 FPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVL 228

Query: 259 --EGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
              G   + +C+  G P P++EW  + +P+LP    L    ++ G VL++      D G 
Sbjct: 229 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQV--QEDGQVLRITGSHVGDEGR 286

Query: 317 YVCAARNSAGQTLSAVQLHV-KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFR 375
           Y C A + AGQ     QL V   P +  +    +V   E  +  L C+      P   + 
Sbjct: 287 YQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF 346

Query: 376 EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVT 425
           +D  LLP         G  R+L + R ++ D G+Y C+    V      T
Sbjct: 347 KDGALLPTSTKVVYTRGG-RQLQLGRAQSSDAGVYTCKASNAVGAAEKAT 395



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 87/316 (27%), Positives = 126/316 (39%), Gaps = 50/316 (15%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
           V V+     +L C   G P P + W K G  L  S ++ +   G +  L L  A  +DAG
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ--LQLGRAQSSDAG 378

Query: 81  VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
           VY C+A NA G A  A  + V  PP  +             G+G G P  +        +
Sbjct: 379 VYTCKASNAVGAAEKATRLDVYVPPTIE-------------GAG-GRPYVVK------AV 418

Query: 141 RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
            G  V L C A G P PTL W  +G+ + E   S+   L+     DG      LR+ +  
Sbjct: 419 AGRPVALECVARGHPSPTLSWHHEGLPVAE---SNESRLE----TDGS----VLRLESPG 467

Query: 201 LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEG 260
              SG+Y C A +  G A     ++V  PP+   A+       +V              G
Sbjct: 468 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV--------------G 513

Query: 261 KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
           +  +  C   G P P I+W   GRP          +    G  L + + +    GL+ C 
Sbjct: 514 QPLELPCQASGSPVPTIQWLQNGRPA---EELAGVQVASQGTTLHIDHVELDHSGLFACQ 570

Query: 321 ARNSAGQTLSAVQLHV 336
           A N AG   + V++ V
Sbjct: 571 ATNEAGTAGAEVEVSV 586



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 95/354 (26%), Positives = 132/354 (37%), Gaps = 59/354 (16%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P F   P    +  G    L+C   G P P + W    + +  +E +S    G+   L  
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPV--TEGVSEQDGGST--LQR 2993

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
             A    D+G YVC A N  G   A + V V E P    E                A  +L
Sbjct: 2994 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGE----------------AFSYL 3037

Query: 132  TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS 191
              P       G  + L C   G P P ++W KDG+ L      SH   Q    ++G    
Sbjct: 3038 VEPV------GGSIQLDCVVRGDPVPDIHWIKDGLPLR----GSHLRHQ---LQNG---- 3080

Query: 192  LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCA 251
             +L I      D+G Y C A N  G A+   +L +   P                  +  
Sbjct: 3081 -SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV----------------FQVE 3123

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            P+   V  G     RC   G+P P IEW   G+PL   RR  +    DG   L+ +  + 
Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRR--LRTLPDGSLWLENV--ET 3179

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVK-EPRLRFTRPLQDVEGREHGIAVLECKV 364
             D G Y C A N  G   +   L V+ EP+  +      + GR+ G+A L   V
Sbjct: 3180 GDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSV 3233



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 131/543 (24%), Positives = 197/543 (36%), Gaps = 71/543 (13%)

Query: 11  PPCFLRFPRPVRV--VSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
           PP      R   V  ++G    L+C   G P P +VW K  Q +     L +   G + G
Sbjct: 94  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP--LGWAGYGWDLG 151

Query: 69  LLLTAA---LPTDAGVYVCRAR-NAAGEAYAAAAVTVLEPPASDPELQPAER-PLPSPGS 123
                    L     ++  R +   +G   A A  +          L   E+ P P   S
Sbjct: 152 WGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFS 211

Query: 124 GEGAPVFLTGPRSQWVL--RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQP 181
               P  L    +Q VL   GA+V L C   G+P P + W KD   +  +    H  +Q 
Sbjct: 212 PPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV--LPGGPHLQVQ- 268

Query: 182 GRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAP 241
              EDG      LRI  + + D G Y C A +  G       L+VH PP    ++     
Sbjct: 269 ---EDGQ----VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV 321

Query: 242 APVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGG 301
           A              V E    +  C   G P P I W  +G  LLP   +++Y    GG
Sbjct: 322 A--------------VMEDHLVQLLCEARGVPTPNITWFKDGA-LLPTSTKVVYTR--GG 364

Query: 302 FVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGI---- 357
             L++   Q+ D G+Y C A N+ G    A +L V  P       ++   GR + +    
Sbjct: 365 RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP-----PTIEGAGGRPYVVKAVA 419

Query: 358 ---AVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE 413
                LEC       PT +W  E   +    +     +G+V RL          G+Y C 
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRL--ESPGEASSGLYSCV 477

Query: 414 MRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLV--ETLEAGVEG--------RWSR 463
                       ++  +  ++P +L V EG   V  +  + LE   +         +W +
Sbjct: 478 ASS---PAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ 534

Query: 464 DG---EELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGP 520
           +G   EEL  +  +S G    L +  V  + +G       N   T    V+   H    P
Sbjct: 535 NGRPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAP 592

Query: 521 PIL 523
            +L
Sbjct: 593 GVL 595



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 100/402 (24%), Positives = 137/402 (34%), Gaps = 60/402 (14%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
           V  + G   EL C   G P P + W + G+       +   + G    L +       +G
Sbjct: 508 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT--LHIDHVELDHSG 565

Query: 81  VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
           ++ C+A N AG A A   V+V                      GE AP  L  P  Q+  
Sbjct: 566 LFACQATNEAGTAGAEVEVSV---------------------HGEWAPGVLEVPIGQYHW 604

Query: 141 RGAEVVLTCRAGGLPEPTLYWEKDGMA-LDEVWDSSHFALQPGRAEDGP-GASLA----- 193
            G E   +  A   P     W       L E W S      PG     P G  +A     
Sbjct: 605 -GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS------PGSLWGEPTGIPVAYSLPP 657

Query: 194 -LRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
            L+I    L D G+Y C A N  G ++    L+V  PP   P   ++A            
Sbjct: 658 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKA------------ 705

Query: 253 KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
               V E       C   G P P++ W    +P+       +  D   G VL++   Q  
Sbjct: 706 ----VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD---GRVLRIEQAQLS 758

Query: 313 DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPT- 371
           D G Y C A N AG T     L V  P      P        +    L C    +  PT 
Sbjct: 759 DAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTL 818

Query: 372 AWFREDQRLLPC-RKYEQIEEGTVRRLIIHRLKADDDGIYLC 412
            W ++   + P      Q+  G  R L +   +A D G Y C
Sbjct: 819 MWLKDGNPVSPAGTPGLQVFPGG-RVLTLASARASDSGRYSC 859



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 38/96 (39%), Positives = 46/96 (47%), Gaps = 3/96 (3%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            S P F   P+ + V SG +  L+C   GEP P + W + GQ L AS RL    DG+   L
Sbjct: 3116 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS---L 3172

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             L      DAG Y C A N  G A A A + V   P
Sbjct: 3173 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  321 bits (822), Expect = 5e-87
 Identities = 516/2007 (25%), Positives = 765/2007 (38%), Gaps = 277/2007 (13%)

Query: 18   PRPVR--VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAAL 75
            P PV   V+  A   L+C+  G PPP V W KG Q +++   ++   DG    L +  A 
Sbjct: 608  PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQ 665

Query: 76   PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR 135
             +DAG Y C A N AG       + V  PP     L P+   LP P              
Sbjct: 666  LSDAGSYRCVASNVAGSTELRYGLRVNVPPRI--TLPPS---LPGP-------------- 706

Query: 136  SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALR 195
               VL    V LTC A G P PTL W KDG  +             GR          L 
Sbjct: 707  ---VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR---------VLT 754

Query: 196  ILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTF 255
            + +AR  DSG Y C A +A G  +   +LQVH P           P+ + E L  +    
Sbjct: 755  LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMP-----------PSILGEELNVS---- 799

Query: 256  WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRG 315
             V   +     C     P P + W  +GRPL P     +  D+    +L+V      D G
Sbjct: 800  -VVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADK---ALLQVDRADVWDAG 855

Query: 316  LYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFR 375
             Y C A N AG +     L+V    +   R    +  RE     L C+      P   +R
Sbjct: 856  HYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWR 915

Query: 376  EDQRLLPCRKYEQIEEGTVRRLI-IHRLKADDDGIYLCEMRGRVRTVAN---------VT 425
            +D + LP           V RL+ + + +   +G Y CE    V   +            
Sbjct: 916  KDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 975

Query: 426  VKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGE----ELPVICQSS 475
            + GP  +  P ++ V++       V TLE    G+      W RDG+    EL +  Q+ 
Sbjct: 976  IAGP--REPPTQVSVVQDG-----VATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQ 1028

Query: 476  SGHMHALVLPGVTREDAGEVTFSLGNS-----RTTTLLRVKCVKHSPPGPPILAEMFKGH 530
               +H              V  +L          + L+  + +    P   I A +   H
Sbjct: 1029 GQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAAL---H 1085

Query: 531  KNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRF 590
                LL      P P   +    E    G + ++    +     +++        G Y  
Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYL----LAGGWMLKMTQTQEQDSGLYSC 1141

Query: 591  RICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDV-QVYDGEDAVFSLDLSTIIQG--TW 647
                 +G  R    V      LVP +     LE+V +V DG+ A    +++   Q   TW
Sbjct: 1142 LASNEAGEARRNFSV----EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW 1197

Query: 648  FLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA 707
            F +G  L   +    + P  +  ++ Q  L        +    +   VG      Q    
Sbjct: 1198 FKDGRPLARGDAH-HISPDGVLLQVLQANLSSAGHYSCI----AANAVGEKTKHFQ---- 1248

Query: 708  LTIQESPVHILSPQDRV--SLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVV 764
            L++  +P  +   +D     +T T +  + L CE      P  TW KDG   E S    +
Sbjct: 1249 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR--NI 1306

Query: 765  KMDGRKHRLILPEAKVQDSGEFECRT-----EGVSAFFGVTVQDPPVHIVDPREHVFVHA 819
            ++    H L +  A+ +D+G++ C       E V  +    +  P +   DP   V V  
Sbjct: 1307 QLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKE 1366

Query: 820  I---TSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            +    +  + L CE      P +RWYKDGQ V  S  + +  EG  R L +  TQ SD G
Sbjct: 1367 VKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSDSG 1424

Query: 876  EFQC----VAGDECAYFTVTIT---------------DVSSWIVYPSGKV--YVAAVRLE 914
             + C    VAG++   F V I                ++ S      G V  Y   V   
Sbjct: 1425 RYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENN 1484

Query: 915  RVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC--- 970
               L C+    P  ++ W ++ + +     + + +   V  L +P V+ E++G Y C   
Sbjct: 1485 PAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV--LQIPLVRAENAGRYSCKAS 1542

Query: 971  -EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV-LMCELSREDAP-VRWYKDGL 1027
             E+ ++   + + V  PPV +    + V  + V     V L C       P + W ++GL
Sbjct: 1543 NEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGL 1602

Query: 1028 EVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVH 1083
                S  L +  DG    L +  A+  D   ++C     AG     FT+ V  PP     
Sbjct: 1603 PFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR---- 1656

Query: 1084 PAARSLDLHFGAP---GRVELRCEV-APAGSQVRWYKDGLEVEASDALQLGAE----GPT 1135
                 LDL          V L C+V A    +V WYKD      S AL LG E      T
Sbjct: 1657 --IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKD------SQALSLGEEVFLLPGT 1708

Query: 1136 RTLTLPHAQPEDAGEYVCETRHEA------ITFNVILAEPPVQFLALETTPSPLCVAPGE 1189
             TL L  A+  D+G Y CE  + A      +  +V++  PP    A       + V  G+
Sbjct: 1709 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV--PPAFRQAPRGPQDAVLVRVGD 1766

Query: 1190 PVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
              VLSCE      P V W  +G+P+   +  +    G R  L IQ A  +  GLY+C+  
Sbjct: 1767 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR--LEIQEAQVSDKGLYSCKVS 1824

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGE 1307
               G    +FT+ V  PP            V    G  L L   +SG P   V W KD  
Sbjct: 1825 NVAGEAVRTFTLTVQVPP---TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRM 1881

Query: 1308 RLASQGRVQLEQAGAR-QVLRVQGARSGDAGEYLCDA----PQDSRIFLVSVEEPLLVKL 1362
             + S     +   G R Q+ R+Q A+   AG Y C A     +  + F+V+V     ++ 
Sbjct: 1882 PVESSAVHGVVSRGGRLQLSRLQPAQ---AGTYTCVAENTQAEARKDFVVAVLVAPRIRS 1938

Query: 1363 VSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVV--TPGPQVEMAQNGSSRILTLR 1419
                    V EG +    CE    P  DV WL++G+ +    GP +    +G S  L L+
Sbjct: 1939 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGS--LVLK 1996

Query: 1420 GCQLGDAGTVTLRAGSTA-TSARLHVRETELLFLRRLQDVRAEEGQDVCL--EVETGRVG 1476
            G +  DAG  T  A + A   ARLH     +L    ++      G  V    E+ T    
Sbjct: 1997 GLRASDAGAYTCVAHNPAGEDARLHT--VNVLVPPTIKQGADGSGTLVSRPGELVTMVCP 2054

Query: 1477 AAGA----VRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLA- 1531
              G+    V W++ G PLP   R  +   GH  R  I  V LAD G + C +     +A 
Sbjct: 2055 VRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLR--ISKVQLADAGIFTCVAASPAGVAD 2112

Query: 1532 -RLSVRPRQLRVLRPLE---DVTISEGGSATFQLELSQEGV---TGEWARGGVQLYPGPK 1584
               +++ +   VL P+E   DV +  G  +  +L     GV      W + G  L     
Sbjct: 2113 RNFTLQVQVPPVLEPVEFQNDVVVVRG--SLVELPCEARGVPLPLVSWMKDGEPLLS--- 2167

Query: 1585 CHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPH-------- 1636
                S      L L  +G  DSG  S  A S    AR   R   +T++  PH        
Sbjct: 2168 ---QSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR---RHFQLTVMEPPHIEDSGQPT 2221

Query: 1637 DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
            +L +T G      C+       ++TW KDG ALT   RL   +  T R+L++R     DA
Sbjct: 2222 ELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT---RLENNSRAT-RVLRVR-----DA 2272

Query: 1696 GTYSCAVGTARAGPVRLTVRERTVAVLSEL-----RSVSAREGDGATFECTV-SEVETTG 1749
            G Y+C +  + AG +  + R R  A  + +     R V          EC+V +E     
Sbjct: 2273 GLYTC-LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKI 2331

Query: 1750 RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVEA 1805
             W   G  L+  A  +  + G+   L L  L   D+G+     R  AG       +E+  
Sbjct: 2332 TWHRDGIVLQEDAHTQFPERGR--FLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT 2389

Query: 1806 LPLQMCRHPPREKTVLVGRRAVLEVTVSR-SGGHVCWLREGAELCP-GDKYEMRSHGPTH 1863
            +P    R  P    V V + A+L           V W ++   L P   ++E+   G   
Sbjct: 2390 VP--TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG--- 2444

Query: 1864 SLVIHDVRPEDQGTYCCQAGQDSTHTR 1890
            SL I  V  +D G Y C A   +   R
Sbjct: 2445 SLRIQPVLAQDAGHYLCLASNSAGSDR 2471



 Score =  288 bits (737), Expect = 3e-77
 Identities = 508/2005 (25%), Positives = 745/2005 (37%), Gaps = 260/2005 (12%)

Query: 15   LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
            LR    + V  G    L C   G P P + W K GQ L                L L  A
Sbjct: 884  LRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 943

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
                 G Y C   N  G +     + V  PP      +P                    P
Sbjct: 944  QLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREP--------------------P 983

Query: 135  RSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG---PGAS 191
                V++     L C A G P PT+ WE+DG              QP  AE G       
Sbjct: 984  TQVSVVQDGVATLECNATGKPPPTVTWERDG--------------QPVGAELGLQLQNQG 1029

Query: 192  LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCA 251
             +L +  A+   +G Y C A N  G A+    L V  PPE      D  P   +     +
Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE---LIGDLDPLTNITAALHS 1086

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            P T            C  MG P P I W     P+ P     +     GG++LK+   Q 
Sbjct: 1087 PLTLL----------CEAMGIPPPAIRWFRGEEPVSPGEDTYLLA---GGWMLKMTQTQE 1133

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDV-EGREHGIAVLECKVPNSRIP 370
            +D GLY C A N AG+      + V  P       L++V +  +   A L C V     P
Sbjct: 1134 QDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1193

Query: 371  -TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRV---------RT 420
               WF++ + L     +    +G + +++   L +   G Y C     V           
Sbjct: 1194 KLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSS--AGHYSCIAANAVGEKTKHFQLSV 1251

Query: 421  VANVTVKGPILKRLPRKLDVLEGENAVLLVETLE-AGVEGRWSRDGE--ELPVICQSSSG 477
            +   T+ G        ++ V       L+ E L        W +DG   E     Q   G
Sbjct: 1252 LLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG 1311

Query: 478  HMHALVLPGVTREDAGE----VTFSLG----NSRTTTLLRVKCVKHSPPGPPILAEMFKG 529
              H L +    +EDAG+    VT  LG    N     L+     K  P     + E+   
Sbjct: 1312 -THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTK 1370

Query: 530  HKNTVLL---TWKPPEPA--------PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVP 578
              +T+ L   +W  P P         P TP   RL+    G    IQ   +  +G     
Sbjct: 1371 VNSTLTLECESWAVPPPTIRWYKDGQPVTP-SSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1429

Query: 579  GDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAG--LEDVQVYDGEDAVFS 636
               V  E D  F +             F  +  ++       G   E  ++ +   A   
Sbjct: 1430 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489

Query: 637  LDLSTIIQG--TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGAL 694
             D + I     TW+   + L + +    ++ G +            L +  V+ +++G  
Sbjct: 1490 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV------------LQIPLVRAENAGR- 1536

Query: 695  VGFSCPGVQDSA------ALTIQESPVHILSPQDRV-SLTFTTSERVVLTCELSRVDFPA 747
              +SC    +         L +   PV +   ++ V  +T   S  V L C       P 
Sbjct: 1537 --YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPT 1594

Query: 748  -TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE----GVSAFFGVTVQ 802
             +W ++G     S  L V  DG+   L +  A+V D+  + C  E         F + VQ
Sbjct: 1595 ISWLQNGLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1652

Query: 803  DPP-VHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGP 860
             PP +  +D  +   V AI +  V L C+V     P V WYKD Q +   + V L   G 
Sbjct: 1653 VPPRIAGLDLEQ---VTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL-LPGT 1708

Query: 861  HRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRL-ER 915
            H  L L   + SD G + C     AG +     +++    ++   P G      VR+ ++
Sbjct: 1709 H-TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK 1767

Query: 916  VVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVR---RLVLPAVQLEDSGEYLCE 971
             VL+CE    P   V W KDG+     P +L Q+   +R   RL +   Q+ D G Y C+
Sbjct: 1768 AVLSCETDALPEPTVTWYKDGQ-----PLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCK 1822

Query: 972  IDDESA----SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDG 1026
            + + +     +FT+TV  PP     P+ E T+  V    +VL C++S   AP V W KD 
Sbjct: 1823 VSNVAGEAVRTFTLTVQVPPT-FENPKTE-TVSQVAGSPLVLTCDVSGVPAPTVTWLKDR 1880

Query: 1027 LEVEESEAL-VLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA----FFTVTVTAPPERI 1081
            + VE S    V+ R G   RL L   QP   G + C A +  A     F V V   P   
Sbjct: 1881 MPVESSAVHGVVSRGG---RLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR 1937

Query: 1082 VHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDG--LEVEASDALQLGAEGPTRTLT 1139
                AR   +  G   R++   +  P    V W KDG  L  +    L+   +G   +L 
Sbjct: 1938 SSGVAREHHVLEGQEVRLDCEADGQPP-PDVAWLKDGSPLGQDMGPHLRFYLDG--GSLV 1994

Query: 1140 LPHAQPEDAGEYVCETRHEA------ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVL 1193
            L   +  DAG Y C   + A       T NV++  PP      + +   L   PGE V +
Sbjct: 1995 LKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV--PPTIKQGADGS-GTLVSRPGELVTM 2051

Query: 1194 SCELSRAGAP---VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAA 1250
             C +   G+P   V W  +G P+   +   LH  G    L I     A AG++TC + + 
Sbjct: 2052 VCPV--RGSPPIHVSWLKDGLPLPLSQRTLLHGSG--HTLRISKVQLADAGIFTCVAASP 2107

Query: 1251 PGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERL 1309
             G    +FT+QV  PP  V+ P   Q  V    G  +EL     G   P V W KDGE L
Sbjct: 2108 AGVADRNFTLQVQVPP--VLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPL 2165

Query: 1310 ASQGRVQLEQAGARQVLRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSE 1365
             SQ    LEQ  +   L+++   +GD+G Y C    +A +  R F ++V EP  ++   +
Sbjct: 2166 LSQ---SLEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQ 2219

Query: 1366 LTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
             T L++  G      C+    P  ++TW ++G  +T        +N S     LR   + 
Sbjct: 2220 PTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT------RLENNSRATRVLR---VR 2270

Query: 1425 DAGTVTL----RAGSTATSARLHVR-ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAG 1479
            DAG  T      AG+   S R+ V+    ++  R  + V       + LE        A 
Sbjct: 2271 DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSV-EAEPAP 2329

Query: 1480 AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPR- 1538
             + W R G  L  D+     + G    L +  +  AD G Y C + +      ++ R   
Sbjct: 2330 KITWHRDGIVLQEDAHTQFPERGRF--LQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2387

Query: 1539 ----QLRVLRPLEDVTISEGGSATFQLELSQEGVTG---EWARGGVQLYP-GPKCHIHSD 1590
                 +R   P  +V++++    T  L    +GV      W +  V L P  P+  I  +
Sbjct: 2388 HTVPTIRSGPPAVNVSVNQ----TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPE 2443

Query: 1591 GHRHRLVLNGLGLADSG----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTA 1646
            G    L +  +   D+G      S +A S R    L V E P  I   P +L +T    A
Sbjct: 2444 G---SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE-PPAIAPSPSNLTLTAHTPA 2499

Query: 1647 TFECELSQALAD-VTWEKDGNALTPSPRLRLQALGTRRL----LQLRRCGPSDAGTYSCA 1701
               CE S +    V W KDG  L      RLQ    R L    L L   GP D+  + C 
Sbjct: 2500 LLPCEASGSPKPLVVWWKDGQKLD----FRLQQGAYRLLPSNALLLTAPGPQDSAQFECV 2555

Query: 1702 VGTARAGPVRL---TVR-ERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRP 1757
            V        RL   TV    T+A      +V+       T   T     T    + G + 
Sbjct: 2556 VSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQL 2615

Query: 1758 LRPGARVRIRQEGKKHILVLSELRA-EDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPR 1816
               G+  R+   G   I     + A       R  AG A     L V+A P+      P 
Sbjct: 2616 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVV----KPL 2671

Query: 1817 EKTVLVGRRAVLEVTVSRSG---GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE 1873
               V       + +    SG     + W +EG  +  G   ++    P   L I    PE
Sbjct: 2672 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVL---PGGQLRIAHASPE 2728

Query: 1874 DQGTYCC----QAGQDSTHTRLLVE 1894
            D G Y C     AG     TRL+V+
Sbjct: 2729 DAGNYLCIAKNSAGSAMGKTRLVVQ 2753



 Score =  261 bits (668), Expect = 4e-69
 Identities = 485/1940 (25%), Positives = 718/1940 (37%), Gaps = 279/1940 (14%)

Query: 78   DAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQ 137
            D G+Y C A N AGE+    A+ VL PP  +P                       GP ++
Sbjct: 577  DEGIYTCAATNLAGESKREVALKVLVPPNIEP-----------------------GPVNK 613

Query: 138  WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRIL 197
             VL  A V L C A G+P P + W K    +   W     ++  GR          LRI 
Sbjct: 614  AVLENASVTLECLASGVPPPDVSWFKGHQPVSS-WMGVTVSVD-GR---------VLRIE 662

Query: 198  AARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWV 257
             A+L D+G Y C A N  G  +    L+V+ PP      P   P PV+           V
Sbjct: 663  QAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRI--TLPPSLPGPVL-----------V 709

Query: 258  NEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
            N     +  C   G P P + W  +G P+ P     + +   GG VL +   +A D G Y
Sbjct: 710  N--TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGL-QVFPGGRVLTLASARASDSGRY 766

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPT-AWFRE 376
             C A ++ G+    V L V  P       L         +A LEC+      P  +W+++
Sbjct: 767  SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA-LECQSHAMPPPVLSWWKD 825

Query: 377  DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRV-----RTVANVTVKGPIL 431
             + L P        +  +  L + R    D G Y CE   +          NV V     
Sbjct: 826  GRPLEPRPGVHLSADKAL--LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP 883

Query: 432  KRLPRKLDVLEGENAVLLVETLEAGV---EGRWSRDGEELP---VICQSSSGHMHALVLP 485
             R    L V EG    L  E    GV   +  W +DG+ LP      Q  S     L L 
Sbjct: 884  LRESHTLTVREGHPTRLSCEC--RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLG 941

Query: 486  GVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP------GPPILAEMFKGHKNTV--LLT 537
                   G  T    N    +   ++   H PP       PP    + +    T+    T
Sbjct: 942  QAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT 1001

Query: 538  WKPPEPAPETPFIYRLERQEVGSEDWI------QCFSIEKA-----GAVEVPGDCVPSEG 586
             KPP         +  + Q VG+E  +      Q   +E+A     G      + +    
Sbjct: 1002 GKPPPTV-----TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056

Query: 587  DYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT 646
            + +F +  +      P ++      L P   + A L        E     +    I    
Sbjct: 1057 ERKFELSVLV----PPELI----GDLDPLTNITAALHSPLTLLCE--AMGIPPPAI---R 1103

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSA 706
            WF  GEE         V PG   Y +    +   L +   + QDSG    +SC    + A
Sbjct: 1104 WF-RGEE--------PVSPGEDTYLLAGGWM---LKMTQTQEQDSGL---YSCL-ASNEA 1147

Query: 707  ALTIQESPVHILSPQDRVSLTFTTSERVV---------LTCELSRVDFP-ATWYKDGQKV 756
                +   V +L P    S+     E V+         L C ++    P  TW+KDG+ +
Sbjct: 1148 GEARRNFSVEVLVPP---SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1204

Query: 757  EESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV----SAFFGVTVQDPPVHI--VD 810
               +   +  DG   +++  +A +  +G + C         +  F ++V   P  +   +
Sbjct: 1205 ARGDAHHISPDGVLLQVL--QANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAE 1262

Query: 811  PREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPAT 869
                  V    +  + L CE     +P + W KDG   E S  + L   G H   +L A 
Sbjct: 1263 DSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNA- 1320

Query: 870  QPSDGGEFQCVAGDECA-----YFTVTITDVSSWIVYPSGKVYVAAVRLE-RVVLTCELC 923
            Q  D G++ CV  +E       Y    +   S     P  +V V  V+ +    LT E C
Sbjct: 1321 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLE-C 1379

Query: 924  RPWA----EVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDE 975
              WA     +RW KDG+ V  +P+  LQ     R L +   Q+ DSG YLC       ++
Sbjct: 1380 ESWAVPPPTIRWYKDGQPV--TPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGED 1437

Query: 976  SASFTVTVTEPPV----------RIIYPRDEVTLIAVT--LECV-----VLMCELSREDA 1018
               F V +  PP+            I  R+E     VT   E V      L C+ +    
Sbjct: 1438 DQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPP 1497

Query: 1019 P-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVT 1073
            P + WY++   +   + + + + G    L +P  + E+ G + C A    G+D   + + 
Sbjct: 1498 PDLTWYREDQPLSAGDEVSVLQGGR--VLQIPLVRAENAGRYSCKASNEVGEDWLHYELL 1555

Query: 1074 VTAPPERIVHPAARSLDLHFGAPGRVELRC-EVAPAGSQVRWYKDGLEVEASDALQLGAE 1132
            V  PP  +        ++   A   V L+C  +      + W ++GL    S  LQ+  +
Sbjct: 1556 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1615

Query: 1133 GPTRTLTLPHAQPEDAGEYVCETRHEAIT----FNVILAEPP-VQFLALETTPSPLCVAP 1187
            G  + L +  A+  DA  Y+C   ++A +    F + +  PP +  L LE   + L    
Sbjct: 1616 G--QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAIL---- 1669

Query: 1188 GEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQ 1246
               V L C++     P V W  + + +  GE  E+        L +  A  + +G+YTC+
Sbjct: 1670 NSSVSLPCDVHAHPNPEVTWYKDSQALSLGE--EVFLLPGTHTLQLGRARLSDSGMYTCE 1727

Query: 1247 SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKD 1305
            +  A G       + V  PP    AP   Q  V    G    L       P   V WYKD
Sbjct: 1728 ALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKD 1787

Query: 1306 GERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCD----APQDSRIFLVSVEEPLLVK 1361
            G+ L    R Q  + G R  L +Q A+  D G Y C     A +  R F ++V+ P   +
Sbjct: 1788 GQPLVLAQRTQALRGGQR--LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFE 1845

Query: 1362 LVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRG 1420
                 T   V  G      C+VS  P   VTWL++   V       +   G    L L  
Sbjct: 1846 NPKTETVSQV-AGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGR--LQLSR 1902

Query: 1421 CQLGDAGTVTLRAGSTATSARLHVRETELLFLR-RLQDVRAE----EGQDVCLEVETGRV 1475
             Q   AGT T  A +T   AR       L+  R R   V  E    EGQ+V L+ E    
Sbjct: 1903 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQ 1962

Query: 1476 GAAGAVRWVRGGQPLPHD--SRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARL 1533
                 V W++ G PL  D    L    DG    L + G+  +D G Y C +H+    A  
Sbjct: 1963 PPPD-VAWLKDGSPLGQDMGPHLRFYLDG--GSLVLKGLRASDAGAYTCVAHNP---AGE 2016

Query: 1534 SVRPRQLRVLRPLEDVTISEGGSATFQLELSQEG--------------VTGEWARGGVQL 1579
              R   + VL P    TI +G   +  L +S+ G              +   W + G+ L
Sbjct: 2017 DARLHTVNVLVP---PTIKQGADGSGTL-VSRPGELVTMVCPVRGSPPIHVSWLKDGLPL 2072

Query: 1580 YPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADS-LRCAARLIVREVPVTIVRGP--- 1635
                +  +H  GH  R  ++ + LAD+G  +  A S    A R    +V V  V  P   
Sbjct: 2073 PLSQRTLLHGSGHTLR--ISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEF 2130

Query: 1636 -HDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPS 1693
             +D+ V  G      CE     L  V+W KDG  L        Q+L     LQL   G  
Sbjct: 2131 QNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLS------QSLEQGPSLQLEAVGAG 2184

Query: 1694 DAGTYSCAVGTARAGPVR----LTVRERT-VAVLSELRSVSAREGDGATFECTVSEV-ET 1747
            D+GTYSC V  + AG  R    LTV E   +    +   +S   G      C      + 
Sbjct: 2185 DSGTYSC-VAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 2243

Query: 1748 TGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG----EVRFQAGPAQSLALLEV 1803
               W   G+ L      R+    +        LR  DAG         AG  +    + V
Sbjct: 2244 NITWHKDGQAL-----TRLENNSR----ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRV 2294

Query: 1804 EALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYEMRSHGPT 1862
            +A P  +    PR    L   + VLE +V +     + W R+G  L      +    G  
Sbjct: 2295 QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG-- 2352

Query: 1863 HSLVIHDVRPEDQGTYCCQA 1882
              L +  +   D G Y C A
Sbjct: 2353 RFLQLQALSTADSGDYSCTA 2372



 Score =  226 bits (575), Expect = 2e-58
 Identities = 463/1997 (23%), Positives = 723/1997 (36%), Gaps = 272/1997 (13%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V V       L C  L  P P + W K G    AS  +        HGL +  A   DAG
Sbjct: 1269 VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP--GTHGLQILNAQKEDAG 1326

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
             Y C   N  GEA     V VL PP+   +                 P+   G +     
Sbjct: 1327 QYTCVVTNELGEAVKNYHVEVLIPPSISKD----------------DPLAEVGVKEVKTK 1370

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
              + + L C +  +P PT+ W KDG             + P       G    L+I   +
Sbjct: 1371 VNSTLTLECESWAVPPPTIRWYKDGQ-----------PVTPSSRLQVLGEGRLLQIQPTQ 1419

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV----EPLKCAPKTFW 256
            + DSG Y+C A N  G       + +  PP         A   ++    E      +   
Sbjct: 1420 VSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYRE 1479

Query: 257  VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
            + E   A   C     P P++ W+ E +PL       + +   GG VL++   +A++ G 
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ---GGRVLQIPLVRAENAGR 1536

Query: 317  YVCAARNSAGQTLSAVQLHVKEPR--LRFTRPL-QDVEGREHGIAVLECKVPNSRIPT-A 372
            Y C A N  G+     +L V  P   L  T  L ++V         L+C    + +PT +
Sbjct: 1537 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1596

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            W +      P  + + +E+G V  L +   +  D   Y+C    +  +   +     +  
Sbjct: 1597 WLQNGLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFT---LRV 1651

Query: 433  RLPRKLDVLEGENAVLLVET---------LEAGVEGRWSRDGEELPVICQSSSGHMHALV 483
            ++P ++  L+ E    ++ +              E  W +D + L      S G     +
Sbjct: 1652 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL------SLGE-EVFL 1704

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRV-----KCVKHSPPGPPILAEMFKGHKNTVLLTW 538
            LPG      G    S     T   L       K V+ S   PP   +  +G ++ VL+  
Sbjct: 1705 LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV 1764

Query: 539  K-------PPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
                      +  PE    +  + Q +      Q  ++     +E+    V  +G Y  +
Sbjct: 1765 GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQ--ALRGGQRLEIQEAQVSDKGLYSCK 1822

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFL 649
            +  V+G        F  +  + PT       E V    G   V + D+S +     TW  
Sbjct: 1823 VSNVAGEAVR---TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK 1878

Query: 650  NGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALT 709
            +   ++S+   G V  G             RL L  ++   +G    ++C      A   
Sbjct: 1879 DRMPVESSAVHGVVSRGG------------RLQLSRLQPAQAGT---YTCVAENTQAEAR 1923

Query: 710  IQESPVHILSPQDRVSLT-----FTTSERVVLTCELSRVDFP-ATWYKDGQKV--EESEL 761
                   +++P+ R S           + V L CE      P   W KDG  +  +    
Sbjct: 1924 KDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPH 1983

Query: 762  LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA----FFGVTVQDPPVHIVDPREHVFV 817
            L   +DG    L+L   +  D+G + C     +        V V  PP           +
Sbjct: 1984 LRFYLDGGS--LVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTL 2041

Query: 818  HAITSECVMLACEVDREDAP--VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
             +   E V + C V R   P  V W KDG  +  S   +L   G    L +   Q +D G
Sbjct: 2042 VSRPGELVTMVCPV-RGSPPIHVSWLKDGLPLPLSQRTLLHGSG--HTLRISKVQLADAG 2098

Query: 876  EFQCVA------GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR-PWAE 928
             F CVA       D      V +  V   + + +    V  VR   V L CE    P   
Sbjct: 2099 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQND---VVVVRGSLVELPCEARGVPLPL 2155

Query: 929  VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVT 984
            V W KDGE       LL Q  +    L L AV   DSG Y C    E  +    F +TV 
Sbjct: 2156 VSWMKDGE------PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM 2209

Query: 985  EPPVRIIYPRDEVTLIAVTLEC-VVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGP 1042
            EPP   I    + T +++T    + L+C+      P + W+KDG      +AL    +  
Sbjct: 2210 EPP--HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG------QALTRLENNS 2261

Query: 1043 RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR 1098
            R   VL   +  D G + C     AG     F V V APP  IV P      +   APG+
Sbjct: 2262 RATRVL---RVRDAGLYTCLAESPAGAIEKSFRVRVQAPP-NIVGPRGPRFVVGL-APGQ 2316

Query: 1099 VELRCEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH 1157
            + L C V A    ++ W++DG+ ++     Q    G  R L L      D+G+Y C  R+
Sbjct: 2317 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG--RFLQLQALSTADSGDYSCTARN 2374

Query: 1158 EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQ-E 1215
             A + +V           + + P  + V+  +  +L C+     AP+V W  +  P+   
Sbjct: 2375 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 2434

Query: 1216 GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
                E+  EG  R   IQ      AG Y C +  + G+      ++V EPP   +AP  +
Sbjct: 2435 SPRFEILPEGSLR---IQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP--AIAPSPS 2489

Query: 1276 Q-TRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERL---ASQGRVQLEQAGARQVLRVQG 1330
              T    TP     L    SG   P V W+KDG++L     QG  +L  + A   L +  
Sbjct: 2490 NLTLTAHTPA---LLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---LLLTA 2543

Query: 1331 ARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRC-EVSP 1385
                D+ ++ C    +  +  R++ V+V  P    +  + T  TV         C     
Sbjct: 2544 PGPQDSAQFECVVSNEVGEAHRLYQVTVHVP--PTIADDQTDFTVTMMAPVVLTCHSTGI 2601

Query: 1386 PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD-----AGTVTLRAGSTATSA 1440
            P   V+W + GA +        A+    R+      ++G      AG  T  A ++A  A
Sbjct: 2602 PAPTVSWSKAGAQLG-------ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 2654

Query: 1441 RLHVRETELL--FLRRLQD-VRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLS 1497
              HV  T      ++ L   VRA   ++V L  E   +     + W + G  +       
Sbjct: 2655 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI-PRPTITWQKEGLNVATGVSTQ 2713

Query: 1498 MAQDGHIHRLFIHGVILADQGTYGCESHHDRTLA----RLSVRPRQLRVLRPLEDVTISE 1553
            +   G   +L I      D G Y C + +    A    RL V+   + +   L D++ +E
Sbjct: 2714 VLPGG---QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLPDLSTTE 2769

Query: 1554 G----------GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            G          GS    +   ++G     A G   + P  +           L++  L  
Sbjct: 2770 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-----------LLVKNLEG 2818

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
             D+G  + TA++    AR   R V +TI+  P           T   + S  L D  W +
Sbjct: 2819 QDAGTYTCTAENAVGRAR---RRVHLTILVLP--------VFTTLPGDRSLRLGDRLWLR 2867

Query: 1664 DGNALTPSPRL------RLQALGTRR-----LLQLRRCGPSDAGTYSC----AVGTARAG 1708
                 +P+PR+      R    G         LQ       D+GTY C     VG  +A 
Sbjct: 2868 CAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV 2927

Query: 1709 PVRLTVRERTVAVLSELRSVSAREGDGATFECTV-SEVETTGRWELGGRPLRPGARVRIR 1767
               + V+E  V        +    G     +C V  +      W   G PLR      +R
Sbjct: 2928 SF-VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGS---HLR 2983

Query: 1768 QEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVEALPLQMCRHPPREKTVLVG 1823
             + +   L +     +DAG  +  A    G A+ + +L +++ P+      P++ TV  G
Sbjct: 2984 HQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVE--PQDMTVRSG 3041

Query: 1824 RRAVLEV-TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
                L           + WL+ G  L    +       P  SL + +V   D GTY C A
Sbjct: 3042 DDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL---PDGSLWLENVETGDAGTYDCVA 3098

Query: 1883 ----GQDSTHTRLLVEG 1895
                G  +    L+V G
Sbjct: 3099 HNLLGSATARAFLVVRG 3115



 Score =  172 bits (436), Expect = 3e-42
 Identities = 327/1404 (23%), Positives = 523/1404 (37%), Gaps = 147/1404 (10%)

Query: 585  EGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQ 644
            EGD     C       +    FH      P+       ++V    G D    ++L     
Sbjct: 96   EGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD----VELQCWTS 151

Query: 645  GTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD 704
            G      E  K  +P   V PG    ++++ G   R+    V  +     V FS  G Q 
Sbjct: 152  GVPTPQVEWTKDRQP---VLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA 208

Query: 705  SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLV 763
                    +P  I    +   +       V L CE   V  P  TW+KDG  +  S  +V
Sbjct: 209  RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268

Query: 764  VKMDGRKHRLILPEAKVQDSGEFECR-TEGVSAFFGVTVQD----PPVHIVDPREHVFVH 818
                GR+  L L  A+  D+G + C+ +  V A    T  D    P +     R +V V 
Sbjct: 269  YTRGGRQ--LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV-VK 325

Query: 819  AITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEF 877
            A+    V L C      +P + W+ +G  V ES+   LE +G   RL  P    S  G +
Sbjct: 326  AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASS--GLY 383

Query: 878  QCVA----GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWT 932
             CVA    G+    ++V +  V   ++   G   V  +  + + L C+    P   ++W 
Sbjct: 384  SCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWL 442

Query: 933  KDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS------------FT 980
            ++G    E   + +  + T   L +  V+L+ SG + C+  +E+ +            + 
Sbjct: 443  QNGRPAEELAGVQVASQGTT--LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWA 500

Query: 981  VTVTEPPV-RIIYPRDEVTLIAVTLECVVLMCELSREDAPV--RWYKDGLEVEESEALVL 1037
              V E P+ +  +  +  +      +  V     +    P+   W   G    E   + +
Sbjct: 501  PGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV 560

Query: 1038 ERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTAPPERIVHPAARSLDLHF 1093
                P   L +      D G + C A    G+      + V  PP   + P   +  +  
Sbjct: 561  AYSLPP-PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN--IEPGPVNKAVLE 617

Query: 1094 GAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVC 1153
             A   +E      P    V W+K    V +   + +  +G  R L +  AQ  DAG Y C
Sbjct: 618  NASVTLECLASGVPP-PDVSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYRC 674

Query: 1154 ETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSH 1208
               + A    + + + +  PP +     + P P+ V    PV L+C  + A +P ++W  
Sbjct: 675  VASNVAGSTELRYGLRVNVPP-RITLPPSLPGPVLV--NTPVRLTCNATGAPSPTLMWLK 731

Query: 1209 NGRPVQEG--EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
            +G PV      GL++   G  RVL + +A  + +G Y+C + +A G       +QV  PP
Sbjct: 732  DGNPVSPAGTPGLQVFPGG--RVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 789

Query: 1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPV-RWYKDGERLASQGRVQLEQAGARQV 1325
               +  E     V +     LE   H   P  PV  W+KDG  L  +  V L  +  + +
Sbjct: 790  --SILGEELNVSVVANESVALECQSHAMPP--PVLSWWKDGRPLEPRPGVHL--SADKAL 843

Query: 1326 LRVQGARSGDAGEYLCD----APQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRC 1381
            L+V  A   DAG Y C+    A    + + ++V    +  L  E   LTV EG      C
Sbjct: 844  LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPL-RESHTLTVREGHPTRLSC 902

Query: 1382 EV-SPPDADVTWLRNGAVVTPGPQVEMAQ-NGSSRILTLRGCQLGDAGTVTLR----AGS 1435
            E    P   ++W ++G  + PG    +   +   R+L L   QL   GT T       G+
Sbjct: 903  ECRGVPFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGN 961

Query: 1436 TATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVG-AAGAVRWVRGGQPLPHDS 1494
            ++   +L V     +   R    +    QD    +E    G     V W R GQP+  + 
Sbjct: 962  SSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 1021

Query: 1495 RLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLAR------LSVRPRQLRVLRPLED 1548
             L +   G    L +     A  G Y C + +    A       + V P  +  L PL +
Sbjct: 1022 GLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN 1079

Query: 1549 VTISEGGSATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG 1607
            +T +     T   E +        W RG   + PG   ++ + G    L +      DSG
Sbjct: 1080 ITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG--WMLKMTQTQEQDSG 1137

Query: 1608 CVSFTADSLRCAARLIVREVPVTIVRGP----HDLE----VTEGDTATFECELS-QALAD 1658
              S  A +    AR   R   V ++  P     DLE    V +G TA   C ++      
Sbjct: 1138 LYSCLASNEAGEAR---RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1194

Query: 1659 VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERT 1718
            +TW KDG  L       +   G   LLQ+ +   S AG YSC    A    V    +   
Sbjct: 1195 LTWFKDGRPLARGDAHHISPDGV--LLQVLQANLSSAGHYSCIAANA----VGEKTKHFQ 1248

Query: 1719 VAVLSELRSVSAREGDGATFECTVSEVETTG-------------RWELGGRPLRPGARVR 1765
            ++VL     +   E D A  E TV+                    W   G P      ++
Sbjct: 1249 LSVLLAPTILGGAE-DSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQ 1307

Query: 1766 IRQEGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVEALPLQMCRHPP------ 1815
            +      H L +   + EDAG+    V  + G A     +EV  +P  + +  P      
Sbjct: 1308 LLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV-LIPPSISKDDPLAEVGV 1364

Query: 1816 REKTVLVGRRAVLEV-TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPED 1874
            +E    V     LE  + +     + W ++G  + P  + ++   G    L I   +  D
Sbjct: 1365 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSD 1422

Query: 1875 QGTYCC----QAGQDSTHTRLLVE 1894
             G Y C     AG+D     +L++
Sbjct: 1423 SGRYLCVATNVAGEDDQDFNVLIQ 1446



 Score =  171 bits (432), Expect = 8e-42
 Identities = 278/1182 (23%), Positives = 434/1182 (36%), Gaps = 165/1182 (13%)

Query: 819  AITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQ 878
            ++T EC  LA  V   D  V W+K  Q V     V +  +G  R L +   Q SD G ++
Sbjct: 620  SVTLEC--LASGVPPPD--VSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYR 673

Query: 879  CVAGDECAYFTVTI---TDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWTKD 934
            CVA +      +      +V   I  P        V    V LTC     P   + W KD
Sbjct: 674  CVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP-VRLTCNATGAPSPTLMWLKD 732

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRI 990
            G  V  +    LQ     R L L + +  DSG Y C     + ++     + V  PP  +
Sbjct: 733  GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL 792

Query: 991  IYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLVLP 1049
                +E+ +  V  E V L C+      PV  W+KDG  +E    + L  D  +  L + 
Sbjct: 793  ---GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD--KALLQVD 847

Query: 1050 AAQPEDGGEFVCD----AGDDSAFFTVTVTAPPERIVHPAARS--LDLHFGAPGRVELRC 1103
             A   D G + C+    AG     + + V   P   V P   S  L +  G P R+   C
Sbjct: 848  RADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP---VFPLRESHTLTVREGHPTRLSCEC 904

Query: 1104 EVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFN 1163
               P   ++ W KDG  +    A         R L L  AQ    G Y CE  +      
Sbjct: 905  RGVPF-PKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN------ 957

Query: 1164 VILAEPPVQFLALETTPSPLCVAPGEPV---------VLSCELSRAGAP---VVWSHNGR 1211
              +     Q L LE    P    P EP          V + E +  G P   V W  +G+
Sbjct: 958  --VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 1015

Query: 1212 PVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVA 1271
            PV    GL+L  +G  + L ++ A  AH G Y+C +    G     F + V  PP  ++ 
Sbjct: 1016 PVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP-ELIG 1072

Query: 1272 PEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
                 T + +     L L+    G P   +RW++ GE   S G      AG   +L++  
Sbjct: 1073 DLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR-GEEPVSPGEDTYLLAGG-WMLKMTQ 1130

Query: 1331 ARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS-P 1385
             +  D+G Y C    +A +  R F V V  P  ++       + V +G  A   C V+  
Sbjct: 1131 TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGH 1190

Query: 1386 PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
            P   +TW ++G  +  G    ++ +G   +L +    L  AG  +  A +       H +
Sbjct: 1191 PQPKLTWFKDGRPLARGDAHHISPDGV--LLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 1248

Query: 1446 ETELLFLRRLQDVRAEEGQDVCLEVET-------GRVGAAGAVRWVRGGQPLPHDSRLSM 1498
             + LL    L        ++V + V              +  + W++ G P      + +
Sbjct: 1249 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 1308

Query: 1499 AQDGHIHRLFIHGVILADQGTYGC----------ESHHDRTLARLSVRPRQLRVLRPLED 1548
                  H L I      D G Y C          +++H   L      P  +    PL +
Sbjct: 1309 LPG--THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLAE 1361

Query: 1549 VTISE---GGSATFQLELSQEGV---TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
            V + E     ++T  LE     V   T  W + G  + P  +  +  +G    L +    
Sbjct: 1362 VGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQ 1419

Query: 1603 LADSG---CVSFT---------------------ADSLRCAARLIVREVP----VTIVRG 1634
            ++DSG   CV+                             A  ++ RE      VT  R 
Sbjct: 1420 VSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR- 1478

Query: 1635 PHDLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPS 1693
                E+ E + A   C+ +     D+TW ++   L+    + +   G  R+LQ+      
Sbjct: 1479 ----EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRAE 1532

Query: 1694 DAGTYSCAVGT------------ARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC- 1740
            +AG YSC                    PV L   E  V        V+       + +C 
Sbjct: 1533 NAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELV------EEVTVNASSTVSLQCP 1586

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
             +     T  W   G P  P  R+++ ++G+  +L +S     DA         QAG A+
Sbjct: 1587 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 1644

Query: 1797 SLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYE 1855
             L  L V+ +P ++      + T ++     L   V +     V W ++   L  G+  E
Sbjct: 1645 KLFTLRVQ-VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE--E 1701

Query: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQ----AGQDSTHTRLLV 1893
            +     TH+L +   R  D G Y C+    AG+D    +L V
Sbjct: 1702 VFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 1743



 Score =  147 bits (371), Expect = 1e-34
 Identities = 244/1011 (24%), Positives = 387/1011 (38%), Gaps = 123/1011 (12%)

Query: 950  DTVRRLVLPAVQLEDSGEYLCEIDDESAS----FTVTVTEPPVRIIYPRDEVTLIAVTLE 1005
            D  + L  P +Q  DSG Y C  ++++ +    F + V  PP  ++       ++ +   
Sbjct: 84   DEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP-SVLGAGAAQEVLGLAGA 142

Query: 1006 CVVLMCELSREDAP-VRWYKDGLEV-EESEALVLERDGPRCRLVLPAAQPEDGGEFVC-- 1061
             V L C  S    P V W KD   V      L ++ DG   R+    +   D G + C  
Sbjct: 143  DVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT--GSHVGDEGRYQCVA 200

Query: 1062 --DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGS-QVRWYKDG 1118
               AG  +  F + V APP   +  +  + ++       V+L CE     +  + W+KDG
Sbjct: 201  FSPAGQQARDFQLRVHAPPT--IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 258

Query: 1119 LEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH-----EAITFNVILAEPPVQF 1173
              +  S  +     G  R L L  AQ  DAG Y C+  +     E  T   +   P ++ 
Sbjct: 259  ALLPTSTKVVYTRGG--RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE- 315

Query: 1174 LALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCI 1232
                  P  +    G PV L C      +P + W H G PV E     L  +G   VL +
Sbjct: 316  -GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS--VLRL 372

Query: 1233 QAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVH 1292
            ++ G A +GLY+C + +  G   L ++V+V  PP  +VA    Q  V +  G  LEL   
Sbjct: 373  ESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ--VTTIVGQPLELPCQ 430

Query: 1293 LSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL 1351
             SG P   ++W ++G        VQ+   G    L +       +G + C A  ++    
Sbjct: 431  ASGSPVPTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSGLFACQATNEAGTAG 488

Query: 1352 VSVEEPLLVKLVSELTPLTV-------HEGDD--ATFRCEVSP-----------PDADVT 1391
              VE    V +  E  P  +       H G +  ++F     P           P     
Sbjct: 489  AEVE----VSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEG 544

Query: 1392 WLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLF 1451
            W   G++      + +A +     L +    L D G  T  A + A  ++  V       
Sbjct: 545  WCSPGSLWGEPTGIPVAYS-LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA------ 597

Query: 1452 LRRLQDVRAEEGQDVCLEVETGRVG----AAGA----VRWVRGGQPLPHDSRLSMAQDGH 1503
            L+ L     E G      +E   V     A+G     V W +G QP+     ++++ DG 
Sbjct: 598  LKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR 657

Query: 1504 IHRLFIHGVILADQGTYGC------ESHHDRTLARLSVRPR---------QLRVLRPLED 1548
            + R  I    L+D G+Y C       S   R   R++V PR          + V  P+  
Sbjct: 658  VLR--IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRL 715

Query: 1549 VTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG- 1607
               + G  +   + L            G+Q++PG +           L L     +DSG 
Sbjct: 716  TCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV----------LTLASARASDSGR 765

Query: 1608 --CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALAD--VTWEK 1663
              CV+ +A        ++   +P +I+    ++ V   ++   EC+ S A+    ++W K
Sbjct: 766  YSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ-SHAMPPPVLSWWK 824

Query: 1664 DGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAG----PVRLTVRERTV 1719
            DG  L P P + L A   + LLQ+ R    DAG Y+C     +AG       L V    V
Sbjct: 825  DGRPLEPRPGVHLSA--DKALLQVDRADVWDAGHYTCE-ALNQAGHSEKHYNLNVWVAPV 881

Query: 1720 AVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQ-EGKKHILVL 1777
              L E  +++ REG      C    V      W   G+PL PG    ++       +L L
Sbjct: 882  FPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYL 940

Query: 1778 SELRAEDAG----EVRFQAGPAQSLALLEVEALP-LQMCRHPPREKTVLVGRRAVLEVTV 1832
             + +    G    E     G +     LEV   P +   R PP + +V+    A LE   
Sbjct: 941  GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNA 1000

Query: 1833 S-RSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
            + +    V W R+G  +  G +  ++      SL +   +    G Y C A
Sbjct: 1001 TGKPPPTVTWERDGQPV--GAELGLQLQNQGQSLHVERAQAAHTGRYSCVA 1049



 Score =  143 bits (361), Expect = 1e-33
 Identities = 259/1094 (23%), Positives = 412/1094 (37%), Gaps = 168/1094 (15%)

Query: 15   LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
            + F   V VV G+  EL C   G P P+V W K G+ L +      P+      L L A 
Sbjct: 2128 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS------LQLEAV 2181

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
               D+G Y C A + AGEA     +TV+EPP  +   QP E  L                
Sbjct: 2182 GAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTP-------------- 2227

Query: 135  RSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLAL 194
                   GA + L C A G P+P + W KDG AL  + ++S                 A 
Sbjct: 2228 -------GAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR----------------AT 2264

Query: 195  RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKT 254
            R+L  R+ D+G+Y C A +  G  +    ++V  PP             +V P    P+ 
Sbjct: 2265 RVL--RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPN------------IVGPR--GPRF 2308

Query: 255  FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
                        C V  +P P+I WH +G  L  D     + +R  G  L++      D 
Sbjct: 2309 VVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQED-AHTQFPER--GRFLQLQALSTADS 2365

Query: 315  GLYVCAARNSAGQTLSAVQLHVKE-PRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW 373
            G Y C ARN+AG T  A ++ +   P +R   P  +V   +   A+L C+      P   
Sbjct: 2366 GDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQ--TALLPCQADGVPAPLVS 2423

Query: 374  FREDQRLLPCR--KYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTV-K 427
            +R+D+  L  R  ++E + EG++R   I  + A D G YLC      G  R   ++ V +
Sbjct: 2424 WRKDRVPLDPRSPRFEILPEGSLR---IQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE 2480

Query: 428  GPILKRLPRKLDVLEGENAVLLVETLEAGVE-GRWSRDGEELPVICQSSSGHM---HALV 483
             P +   P  L +     A+L  E   +      W +DG++L    Q  +  +   +AL+
Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2540

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNT-----VLLTW 538
            L     +D+ +    + N         +   H    PP +A+       T     VL   
Sbjct: 2541 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIADDQTDFTVTMMAPVVLTCH 2597

Query: 539  KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVP-SEGDYRFRICTVSG 597
                PAP     +     ++G+      + +  +GA+E+ G  +P   G Y    C+   
Sbjct: 2598 STGIPAPTVS--WSKAGAQLGARG--SGYRVSPSGALEI-GQALPIHAGRY---TCSARN 2649

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELK 655
                 H     +    P  + +  +  V+    E+ +   + S I +   TW   G  + 
Sbjct: 2650 SAGVAHKHVFLTVQASPVVKPLPSV--VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVA 2707

Query: 656  SNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSG---ALVGFSCPGVQDSAALTIQE 712
            +      +  G LR            I HA   +D+G    +   S         L +Q 
Sbjct: 2708 TGVSTQVLPGGQLR------------IAHA-SPEDAGNYLCIAKNSAGSAMGKTRLVVQV 2754

Query: 713  SPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESE-LLVVKMDGRK 770
             PV      D   L+ T      L C+      P  TW KDGQ V  +E    ++  G  
Sbjct: 2755 PPVIENGLPD---LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG-- 2809

Query: 771  HRLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVM 826
              L++   + QD+G + C  E           +T+   PV    P +         + + 
Sbjct: 2810 -ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR---SLRLGDRLW 2865

Query: 827  LACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC-----V 880
            L C       P + W  + + V E    V E +G    L   A    D G + C     V
Sbjct: 2866 LRCAARGSPTPRIGWTVNDRPVTEG---VSEQDG-GSTLQRAAVSREDSGTYVCWAENRV 2921

Query: 881  AGDECAYFT------VTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKD 934
               +   F       V   +  S++V P G     +++L+ VV       P  ++ W KD
Sbjct: 2922 GRTQAVSFVHVKEAPVLQGEAFSYLVEPVG----GSIQLDCVVRG----DPVPDIHWIKD 2973

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE----SASFTVTVTEPPVRI 990
            G  +  S    L+ +     L +   + +D+G Y C  ++E         + +   PV  
Sbjct: 2974 GLPLRGSH---LRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQ 3030

Query: 991  IYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLP 1049
            + P+D   +   + + V L C+ + E  P + W + G  +  S  L    DG    L L 
Sbjct: 3031 VEPQD---MTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG---SLWLE 3084

Query: 1050 AAQPEDGGEFVCDA 1063
              +  D G + C A
Sbjct: 3085 NVETGDAGTYDCVA 3098



 Score =  127 bits (319), Expect = 1e-28
 Identities = 137/470 (29%), Positives = 187/470 (39%), Gaps = 84/470 (17%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA---SERLSFPADGAEH 67
            PP          V   A   L C   G P P V W K G QL A     R+S P+   E 
Sbjct: 2574 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVS-PSGALEI 2632

Query: 68   GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            G     ALP  AG Y C ARN+AG A+    +TV        +  P  +PLPS       
Sbjct: 2633 G----QALPIHAGRYTCSARNSAGVAHKHVFLTV--------QASPVVKPLPS------- 2673

Query: 128  PVFLTGPRSQWVLRGA---EVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA 184
                       V+R     EV+L C A G+P PT+ W+K+G+    V       + PG  
Sbjct: 2674 -----------VVRAVAEEEVLLPCEASGIPRPTITWQKEGL---NVATGVSTQVLPGG- 2718

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPV 244
                     LRI  A   D+G Y+C A+N+ G A     L V  PP      PD +    
Sbjct: 2719 --------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLS---- 2766

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVL 304
                          EG HA   C   G PEP I W  +G+P+     +   +   G  ++
Sbjct: 2767 ------------TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQP-SGELLV 2813

Query: 305  KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV 364
            K L  + +D G Y C A N+ G+    V L +    +  T P  D   R      L C  
Sbjct: 2814 KNL--EGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLP-GDRSLRLGDRLWLRCAA 2870

Query: 365  PNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC--EMR-GRVRTV 421
              S  P   +  + R +     EQ    T++R  + R   +D G Y+C  E R GR + V
Sbjct: 2871 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVGRTQAV 2927

Query: 422  ANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVI 471
            + V VK         +  VL+GE    LVE +   ++      G+ +P I
Sbjct: 2928 SFVHVK---------EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDI 2968



 Score =  117 bits (292), Expect = 1e-25
 Identities = 119/430 (27%), Positives = 166/430 (38%), Gaps = 62/430 (14%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP     P  + + +   A L C   G P P+VVW K GQ+L    +         + LL
Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2540

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            LTA  P D+  + C   N  GEA+    VTV  PP    +       + +P         
Sbjct: 2541 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP--------- 2591

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
                          VVLTC + G+P PT+ W K G  L      S + + P         
Sbjct: 2592 --------------VVLTCHSTGIPAPTVSWSKAGAQLGA--RGSGYRVSP--------- 2626

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
            S AL I  A    +G Y C ARN+ G A     L V               +PVV+PL  
Sbjct: 2627 SGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ-------------ASPVVKPL-- 2671

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
             P        +     C   G P P I W  EG   L     +  +   GG  L++ +  
Sbjct: 2672 -PSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPGG-QLRIAHAS 2726

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP 370
             +D G Y+C A+NSAG  +   +L V+ P +     L D+   E   A L CK   S  P
Sbjct: 2727 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLPDLSTTEGSHAFLPCKARGSPEP 2785

Query: 371  T-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVANVTV 426
               W ++ Q +        I+      L++  L+  D G Y C      GR R   ++T+
Sbjct: 2786 NITWDKDGQPVSGAEGKFTIQPS--GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2843

Query: 427  KG-PILKRLP 435
               P+   LP
Sbjct: 2844 LVLPVFTTLP 2853



 Score =  111 bits (277), Expect = 8e-24
 Identities = 127/472 (26%), Positives = 177/472 (37%), Gaps = 69/472 (14%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  L     V VV+     L+C     PPPV+ W K G+ L     +   AD A   L 
Sbjct: 788  PPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL--LQ 845

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +  A   DAG Y C A N AG +     + V                         APVF
Sbjct: 846  VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWV-----------------------APVF 882

Query: 131  -LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
             L    +  V  G    L+C   G+P P + W KDG  L            PG       
Sbjct: 883  PLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPL------------PGEGAGLQH 930

Query: 190  ASLALRIL---AARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
             S   R+L    A+L   G Y C   N  G++     L+VH PP+   A P E P  V  
Sbjct: 931  VSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI--AGPREPPTQVS- 987

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
                      V +   A   C   GKP P + W  +G+P+      L  + ++ G  L V
Sbjct: 988  ----------VVQDGVATLECNATGKPPPTVTWERDGQPV---GAELGLQLQNQGQSLHV 1034

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP--RLRFTRPLQDVEGREHGIAVLECKV 364
               QA   G Y C A N AG+     +L V  P   +    PL ++    H    L C+ 
Sbjct: 1035 ERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEA 1094

Query: 365  PNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRT 420
                 P   WFR ++ + P      +  G + ++   + +  D G+Y C      G  R 
Sbjct: 1095 MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMT--QTQEQDSGLYSCLASNEAGEARR 1152

Query: 421  VANVTVKGPIL---KRLPRKLDVLEGENAVLLVE-TLEAGVEGRWSRDGEEL 468
              +V V  P     + L   + VL+G+ A L+   T     +  W +DG  L
Sbjct: 1153 NFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPL 1204



 Score =  105 bits (262), Expect = 4e-22
 Identities = 196/755 (25%), Positives = 288/755 (38%), Gaps = 80/755 (10%)

Query: 1184 CVAPGEPV---VLSCELSRAGAPVVWSHNGRPVQEGE--GLELHAEGPRRVLCIQAAGPA 1238
            C A G PV   V   +    G P+ W+  G  +  G+  G  L  EG  + L        
Sbjct: 40   CDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG--QSLHFPRIQEG 97

Query: 1239 HAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PG 1297
             +GLY+C++    G     F + V  PP  V+   AAQ  V    G D+EL    SG P 
Sbjct: 98   DSGLYSCRAENQAGTAQRDFHLLVLTPP-SVLGAGAAQ-EVLGLAGADVELQCWTSGVPT 155

Query: 1298 GPVRWYKDGERLASQG-RVQLEQAGARQVLRVQGARSGDAGEYLC----DAPQDSRIFLV 1352
              V W KD + +   G  +Q+++ G  QVLR+ G+  GD G Y C     A Q +R F +
Sbjct: 156  PQVEWTKDRQPVLPGGPHLQVQEDG--QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL 213

Query: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNG 1411
             V  P  +   +E   + V E       CE    P  ++TW ++GA++    +V   + G
Sbjct: 214  RVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG 273

Query: 1412 SSRILTLRGCQLGDAGTVTLRAGST------ATSARLHVRETELLFLRRLQDVRAEEGQD 1465
              R L L   Q  DAG  T +A +       AT   ++V  T      R   V+A  G+ 
Sbjct: 274  --RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP 331

Query: 1466 VCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC--E 1523
            V LE    R   +  + W   G P+   +   +  DG + RL   G   A  G Y C   
Sbjct: 332  VALEC-VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGE--ASSGLYSCVAS 388

Query: 1524 SHHDRTLARLSVR---PRQLRVLRPLEDVTISEGGSATFQLELSQEGV-TGEWARGGVQL 1579
            S     + + SV    P QL V   L  VT   G       + S   V T +W + G   
Sbjct: 389  SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPA 448

Query: 1580 YPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLE 1639
                   + S G    L ++ + L  SG  +  A +    A   V EV V     P  LE
Sbjct: 449  EELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGTAGAEV-EVSVHGEWAPGVLE 505

Query: 1640 VTEGD-------TATFECELSQAL-----------ADVTWEKDGNALTPSPRLRLQALGT 1681
            V  G         ++F       +               W   G +L   P     A   
Sbjct: 506  VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSL 564

Query: 1682 RRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELR------SVSAREGDG 1735
               LQ+ +    D G Y+CA  T  AG  +   RE  + VL          + +  E   
Sbjct: 565  PPPLQIEKVDLRDEGIYTCA-ATNLAGESK---REVALKVLVPPNIEPGPVNKAVLENAS 620

Query: 1736 ATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRF---- 1790
             T EC  S V      W  G +P+     V +  +G+  +L + + +  DAG  R     
Sbjct: 621  VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQLSDAGSYRCVASN 678

Query: 1791 QAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG---HVCWLREGAE 1847
             AG  +    L V  +P ++   P     VLV     + +T + +G     + WL++G  
Sbjct: 679  VAGSTELRYGLRVN-VPPRITLPPSLPGPVLV--NTPVRLTCNATGAPSPTLMWLKDGNP 735

Query: 1848 LCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
            + P     ++       L +   R  D G Y C A
Sbjct: 736  VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVA 770



 Score =  105 bits (262), Expect = 4e-22
 Identities = 107/404 (26%), Positives = 148/404 (36%), Gaps = 63/404 (15%)

Query: 24  VSGAEAELKCVVLGEPPPVVVWEKGGQQ-LAASERLSFPADGAEHGLLLTAALPTDAGVY 82
           ++GA+ EL+C   G P P V W K  Q  L     L    DG    L +T +   D G Y
Sbjct: 139 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDG--QVLRITGSHVGDEGRY 196

Query: 83  VCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRG 142
            C A + AG+      + V  PP                GS E   V         V+  
Sbjct: 197 QCVAFSPAGQQARDFQLRVHAPPT-------------IWGSNETGEVA--------VMED 235

Query: 143 AEVVLTCRAGGLPEPTLYWEKDGMALDE----VWDSSHFALQPGRAEDGPGASLALRILA 198
             V L C A G+P P + W KDG  L      V+      LQ GRA+             
Sbjct: 236 HLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS----------- 284

Query: 199 ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN 258
               D+GVY C A NA G A+    L V+ P             P +E     P      
Sbjct: 285 ----DAGVYTCKASNAVGAAEKATRLDVYVP-------------PTIEGAGGRPYVVKAV 327

Query: 259 EGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYV 318
            G+     C   G P P + WH EG P+       +  D   G VL++        GLY 
Sbjct: 328 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETD---GSVLRLESPGEASSGLYS 384

Query: 319 CAARNSAGQTLSAVQLHVK-EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPT-AWFRE 376
           C A + AG+ +    + V+  P+L     L  V         L C+   S +PT  W + 
Sbjct: 385 CVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN 444

Query: 377 DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT 420
            +        +   +GT   L I  ++ D  G++ C+      T
Sbjct: 445 GRPAEELAGVQVASQGTT--LHIDHVELDHSGLFACQATNEAGT 486



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 87/316 (27%), Positives = 126/316 (39%), Gaps = 50/316 (15%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
           V V+     +L C   G P P + W K G  L  S ++ +   G +  L L  A  +DAG
Sbjct: 230 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ--LQLGRAQSSDAG 287

Query: 81  VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
           VY C+A NA G A  A  + V  PP  +             G+G G P  +        +
Sbjct: 288 VYTCKASNAVGAAEKATRLDVYVPPTIE-------------GAG-GRPYVVK------AV 327

Query: 141 RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
            G  V L C A G P PTL W  +G+ + E   S+   L+     DG      LR+ +  
Sbjct: 328 AGRPVALECVARGHPSPTLSWHHEGLPVAE---SNESRLE----TDGS----VLRLESPG 376

Query: 201 LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEG 260
              SG+Y C A +  G A     ++V  PP+   A+       +V              G
Sbjct: 377 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV--------------G 422

Query: 261 KHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCA 320
           +  +  C   G P P I+W   GRP          +    G  L + + +    GL+ C 
Sbjct: 423 QPLELPCQASGSPVPTIQWLQNGRPA---EELAGVQVASQGTTLHIDHVELDHSGLFACQ 479

Query: 321 ARNSAGQTLSAVQLHV 336
           A N AG   + V++ V
Sbjct: 480 ATNEAGTAGAEVEVSV 495



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 136/551 (24%), Positives = 200/551 (36%), Gaps = 100/551 (18%)

Query: 11  PPCFLRFPRPVRV--VSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
           PP      R   V  ++G    L+C   G P P +VW K  Q +     L +   G + G
Sbjct: 16  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP--LGWAGYGWDLG 73

Query: 69  ---------------LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
                          L        D+G+Y CRA N AG A     + VL PP+       
Sbjct: 74  WGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSV------ 127

Query: 114 AERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWD 173
                     G GA   + G      L GA+V L C   G+P P + W KD   +  +  
Sbjct: 128 ---------LGAGAAQEVLG------LAGADVELQCWTSGVPTPQVEWTKDRQPV--LPG 170

Query: 174 SSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP 233
             H  +Q    EDG      LRI  + + D G Y C A +  G       L+VH PP   
Sbjct: 171 GPHLQVQ----EDGQ----VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW 222

Query: 234 PADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRL 293
            ++     A              V E    +  C   G P P I W  +G  LLP   ++
Sbjct: 223 GSNETGEVA--------------VMEDHLVQLLCEARGVPTPNITWFKDG-ALLPTSTKV 267

Query: 294 MYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGR 353
           +Y    GG  L++   Q+ D G+Y C A N+ G    A +L V  P       ++   GR
Sbjct: 268 VY--TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP-----PTIEGAGGR 320

Query: 354 EHGI-------AVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKAD 405
            + +         LEC       PT +W  E   +    +     +G+V RL        
Sbjct: 321 PYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRL--ESPGEA 378

Query: 406 DDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLV--ETLEAGVEG---- 459
             G+Y C             ++  +  ++P +L V EG   V  +  + LE   +     
Sbjct: 379 SSGLYSCVASS---PAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435

Query: 460 ----RWSRDG---EELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKC 512
               +W ++G   EEL  +  +S G    L +  V  + +G       N   T    V+ 
Sbjct: 436 VPTIQWLQNGRPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGTAGAEVEV 493

Query: 513 VKHSPPGPPIL 523
             H    P +L
Sbjct: 494 SVHGEWAPGVL 504



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 95/354 (26%), Positives = 132/354 (37%), Gaps = 59/354 (16%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P F   P    +  G    L+C   G P P + W    + +  +E +S    G+   L  
Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPV--TEGVSEQDGGST--LQR 2902

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
             A    D+G YVC A N  G   A + V V E P    E                A  +L
Sbjct: 2903 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGE----------------AFSYL 2946

Query: 132  TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS 191
              P       G  + L C   G P P ++W KDG+ L      SH   Q    ++G    
Sbjct: 2947 VEPV------GGSIQLDCVVRGDPVPDIHWIKDGLPLR----GSHLRHQ---LQNG---- 2989

Query: 192  LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCA 251
             +L I      D+G Y C A N  G A+   +L +   P                  +  
Sbjct: 2990 -SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV----------------FQVE 3032

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            P+   V  G     RC   G+P P IEW   G+PL   RR  +    DG   L+ +  + 
Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRR--LRTLPDGSLWLENV--ET 3088

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVK-EPRLRFTRPLQDVEGREHGIAVLECKV 364
             D G Y C A N  G   +   L V+ EP+  +      + GR+ G+A L   V
Sbjct: 3089 GDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSV 3142



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 100/402 (24%), Positives = 137/402 (34%), Gaps = 60/402 (14%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
           V  + G   EL C   G P P + W + G+       +   + G    L +       +G
Sbjct: 417 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT--LHIDHVELDHSG 474

Query: 81  VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
           ++ C+A N AG A A   V+V                      GE AP  L  P  Q+  
Sbjct: 475 LFACQATNEAGTAGAEVEVSV---------------------HGEWAPGVLEVPIGQYHW 513

Query: 141 RGAEVVLTCRAGGLPEPTLYWEKDGMA-LDEVWDSSHFALQPGRAEDGP-GASLA----- 193
            G E   +  A   P     W       L E W S      PG     P G  +A     
Sbjct: 514 -GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS------PGSLWGEPTGIPVAYSLPP 566

Query: 194 -LRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
            L+I    L D G+Y C A N  G ++    L+V  PP   P   ++A            
Sbjct: 567 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKA------------ 614

Query: 253 KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
               V E       C   G P P++ W    +P+       +  D   G VL++   Q  
Sbjct: 615 ----VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD---GRVLRIEQAQLS 667

Query: 313 DRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPT- 371
           D G Y C A N AG T     L V  P      P        +    L C    +  PT 
Sbjct: 668 DAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTL 727

Query: 372 AWFREDQRLLPC-RKYEQIEEGTVRRLIIHRLKADDDGIYLC 412
            W ++   + P      Q+  G  R L +   +A D G Y C
Sbjct: 728 MWLKDGNPVSPAGTPGLQVFPGG-RVLTLASARASDSGRYSC 768



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 113/428 (26%), Positives = 157/428 (36%), Gaps = 69/428 (16%)

Query: 1505 HRLFIHGVIL-------ADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEG--- 1554
            HRL   G  L        D G Y C + +    A+   R   L VL P   +        
Sbjct: 80   HRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQ---RDFHLLVLTPPSVLGAGAAQEV 136

Query: 1555 ---GSATFQLELSQEGVTG---EWARGGVQLYPG-PKCHIHSDGHRHRLVLNGLGLADSG 1607
                 A  +L+    GV     EW +    + PG P   +  DG   R+   G  + D G
Sbjct: 137  LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT--GSHVGDEG 194

Query: 1608 ---CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALAD------ 1658
               CV+F+    +     +    P TI  G ++     G+ A  E  L Q L +      
Sbjct: 195  RYQCVAFSPAGQQARDFQLRVHAPPTIW-GSNET----GEVAVMEDHLVQLLCEARGVPT 249

Query: 1659 --VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC----AVGTA-RAGPVR 1711
              +TW KDG AL P+    +   G R+L QL R   SDAG Y+C    AVG A +A  + 
Sbjct: 250  PNITWFKDG-ALLPTSTKVVYTRGGRQL-QLGRAQSSDAGVYTCKASNAVGAAEKATRLD 307

Query: 1712 LTVRERTVAVLSELRSVSAREGDGATFECTV-SEVETTGRWELGGRPLRPGARVRIRQEG 1770
            + V             V A  G     EC        T  W   G P+      R+  +G
Sbjct: 308  VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG 367

Query: 1771 KKHILVLSELRAEDAGE---------VRFQAGPAQSLALLEVEALPLQMCRHPPREKTVL 1821
                   S LR E  GE             AG A     +EV+  P  +      + T +
Sbjct: 368  -------SVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTI 420

Query: 1822 VGRRAVLEVTVSRSGGHV---CWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
            VG+   LE+    SG  V    WL+ G         ++ S G T  L I  V  +  G +
Sbjct: 421  VGQ--PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT--LHIDHVELDHSGLF 476

Query: 1879 CCQAGQDS 1886
             CQA  ++
Sbjct: 477  ACQATNEA 484



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 38/96 (39%), Positives = 46/96 (47%), Gaps = 3/96 (3%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            S P F   P+ + V SG +  L+C   GEP P + W + GQ L AS RL    DG+   L
Sbjct: 3025 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS---L 3081

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             L      DAG Y C A N  G A A A + V   P
Sbjct: 3082 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  301 bits (772), Expect = 3e-81
 Identities = 472/2000 (23%), Positives = 773/2000 (38%), Gaps = 252/2000 (12%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA-SERLSFPADGAEHGLLLTAALPTDA 79
            V VV      L+C   G P P + W K G  +++ S  L   + G    L LT+A  +D 
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI--LALTSAQISDT 2078

Query: 80   GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWV 139
            G Y C A NAAGE      + V  PP    E Q                          V
Sbjct: 2079 GRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVS-----------------------V 2115

Query: 140  LRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA-----L 194
            L    V L C++  +P PTL W KDG  L +                 PG S++     L
Sbjct: 2116 LISQAVELLCQSDAIPPPTLTWLKDGHPLLKK----------------PGLSISENRSVL 2159

Query: 195  RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKT 254
            +I  A++ D+G Y C A N  G  +    + +  PP    +D                  
Sbjct: 2160 KIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDE--------------LTQ 2205

Query: 255  FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
              V EG      C   G P P + W  +G P+L D    + R   GG  L++   +  D 
Sbjct: 2206 LTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRV-RILSGGRQLQISIAEKSDA 2264

Query: 315  GLYVCAARNSAGQTLSAVQLHVK-EPRLRFT--RPLQDVEGREHGIAVLECKVPNSRIPT 371
             LY C A N AG       L V   P +  +   P + +  R   I+ LEC+V     PT
Sbjct: 2265 ALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSIS-LECEVQGIPPPT 2323

Query: 372  A-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVK 427
              W ++   L+  +  E ++EG + +L    +   D G Y+C    + G      +++V 
Sbjct: 2324 VTWMKDGHPLIKAKGVEILDEGHILQL--KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVH 2381

Query: 428  GPIL----KRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPV---ICQSSSGHM 479
             P       R P  + V+E  +  L  E     +    W +DG  + +   +   S G M
Sbjct: 2382 APPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM 2441

Query: 480  HALVLPGVTREDAGEVTF----SLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVL 535
              L L   T EDAG+ T     + G  R    L V    H   G   L ++    K +V 
Sbjct: 2442 --LRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIV-GENTLEDVKVKEKQSVT 2498

Query: 536  LTWKPP-EPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICT 594
            LT +    P PE    +  + Q +  ++     S  +   +++    VP  G Y     +
Sbjct: 2499 LTCEVTGNPVPE--ITWHKDGQPLQEDEAHHIISGGRF--LQITNVQVPHTGRYTCLASS 2554

Query: 595  VSGH-GRSPHVVFHGSAHLVPTARLVAGL------EDVQVYDGEDA-----VFSLDLSTI 642
             +GH  RS    F  +  + PT   +AG+      EDV V            +S   +TI
Sbjct: 2555 PAGHKSRS----FSLNVFVSPT---IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATI 2607

Query: 643  IQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGV 702
               TWF +G  L+SN    ++ PG    +I      +      V   ++G ++      V
Sbjct: 2608 ---TWFKDGTPLESNR-NIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKV 2663

Query: 703  QDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESEL 761
                 +   +     LSP++   +    +  + L CE   +   + +WYKDGQ ++  + 
Sbjct: 2664 YIPPIINKGDLWGPGLSPKE---VKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH 2720

Query: 762  LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF----FGVTVQDPPV--------HIV 809
            + +  +G  H L + EA++ D+G + C    ++      F V +Q PP         +++
Sbjct: 2721 VNIAANG--HTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNML 2778

Query: 810  DP-REHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLP 867
            D  R       I +  + L CE +    P + WYKDG  +  SD V++   G  R L +P
Sbjct: 2779 DTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG--RVLQIP 2836

Query: 868  ATQPSDGGEFQCVAGDECAYFT------VTITDVSSWIVYPSGKVYVAAVRLERVVLTCE 921
              +  D G + CVA +E    +      V +  +         +     V    ++    
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLS 2896

Query: 922  LCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS--- 978
               P     W KDG+ ++E           + +++    Q+ D G Y+C  ++ + S   
Sbjct: 2897 SGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQIL--NTQITDIGRYVCVAENTAGSAKK 2954

Query: 979  -FTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALV 1036
             F + V  PP  +I P+ E  L  V    + L CE+S    P + W K+   ++ +   +
Sbjct: 2955 YFNLNVHVPP-SVIGPKSE-NLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL 3012

Query: 1037 LERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLH 1092
            +   G   +++   A+  DGGE+ C     AG+    F++TV  PP    H +     ++
Sbjct: 3013 IVPGGRTLQII--RAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVN 3070

Query: 1093 FGAPGRVELRCEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
                  V L CE  A     + WYK+G  +  S  +++ A+G  + L +  A+  D G+Y
Sbjct: 3071 VREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QMLHIKKAEVSDTGQY 3128

Query: 1152 VCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAP-GEPVVLSCELSRAGAPVV- 1205
            VC   + A      F++ +  PP    ++E     + V     PV L+C+ +    P + 
Sbjct: 3129 VCRAINVAGRDDKNFHLNVYVPP----SIEGPEREVIVETISNPVTLTCDATGIPPPTIA 3184

Query: 1206 WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEP 1265
            W  N + ++  + LE+        L I  +  + +G YTC +    G     + + +  P
Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244

Query: 1266 PVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQ 1324
            P   VA     + V    G ++ELV + +G   P ++W KDG+ +AS    ++  +    
Sbjct: 3245 PS--VAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGS 3302

Query: 1325 VLRVQGARSGDAGEYLC----DAPQDSRIFLVSVE-EPLLVKLVSELTPLTVHEGDDATF 1379
             L + GA + D G+Y C     A ++ RIF ++V   P +     E   L          
Sbjct: 3303 TLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINI 3362

Query: 1380 RCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTAT 1438
             C  +  P   + WL+NG  +     + +   G  +++ +   Q+ D    T  A + A 
Sbjct: 3363 ECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG--QVIRIVRAQVSDVAVYTCVASNRAG 3420

Query: 1439 SARLHVR-----ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHD 1493
                H          +      +++   +G    +   T    A  ++ W+R GQPL  D
Sbjct: 3421 VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAP-SMAWLRDGQPLGLD 3479

Query: 1494 SRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRP------LE 1547
            + L+++  G + +L        D G Y C + ++   A    +   L+VL P       E
Sbjct: 3480 AHLTVSTHGMVLQLL--KAETEDSGKYTCIASNE---AGEVSKHFILKVLEPPHINGSEE 3534

Query: 1548 DVTISEGGSATFQLELSQEGVTG---EWARGGVQLYPGPKC-HIHSDGHRHRLVLNGLGL 1603
               IS   +   +L     G+      W + G    P P+   + + G    L ++   +
Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTWMKDG---RPLPQTDQVQTLGGGEVLRISTAQV 3591

Query: 1604 ADSG---CVSFTADSLRCAARLIVREVPVTI--VRGPHDLEVTEGDTATFECELSQALAD 1658
             D+G   C++ +         L+   VP  I     P D+ V      T EC+ S A+  
Sbjct: 3592 EDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECK-SDAVPP 3650

Query: 1659 --VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRE 1716
              +TW ++G  L  +PR+R+ + G  R LQ+      D   Y+C          R  +  
Sbjct: 3651 PVITWLRNGERLQATPRVRILSGG--RYLQINNADLGDTANYTCVASNIAGKTTREFILT 3708

Query: 1717 RTVA--VLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRPLRPG-ARVRIRQEGKK 1772
              V   +    +S+          EC    V T    W   G  L    AR  I + G  
Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFL 3768

Query: 1773 HILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHP-----PREKTVLVGRRAV 1827
            HI         D G     A  A   A  +   + LQ+   P     P   TV+V  +  
Sbjct: 3769 HI---QSAHVTDTGRYLCMATNA---AGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTT 3822

Query: 1828 LEVTVS---------RSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
            L    +         R  GH+  + +       + Y + S G   SLVI     +D  TY
Sbjct: 3823 LACEATGIPKPSINWRKNGHLLNVDQNQ-----NSYRLLSSG---SLVIISPSVDDTATY 3874

Query: 1879 CCQ----AGQDSTHTRLLVE 1894
             C     AG D     L V+
Sbjct: 3875 ECTVTNGAGDDKRTVDLTVQ 3894



 Score =  283 bits (725), Expect = 9e-76
 Identities = 468/1999 (23%), Positives = 772/1999 (38%), Gaps = 281/1999 (14%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP     P+      G+E  + C   G P P + W      +  S R    +DG    L 
Sbjct: 611  PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGT---LF 667

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            +  A P DAG+Y C A N+AG     + +  +E                       AP  
Sbjct: 668  IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE-----------------------APKL 704

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +       V  G   V+ C+  G+P P + W K  +   E+  S+   + P         
Sbjct: 705  MVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDL---ELRPSTFLIIDPLLG------ 755

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE--SPPADPDEAPAPVVEPL 248
               L+I   +  D+G Y C A N  G A     L V  PP     PAD            
Sbjct: 756  --LLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVS---------- 803

Query: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEW-HWEGRPLL--PDRRRLMYRDRDGGFVLK 305
                    +  G +    CYV G PEP I+W   +  P+   P     + + R G   L 
Sbjct: 804  --------MEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG--ALF 853

Query: 306  VLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK---EPRLRFTRPLQDV-EGREHGIAVLE 361
            +L   A D+G Y+C A N  G+  S   + V     P +  +  + +V EG++     L 
Sbjct: 854  ILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQ---LTLP 910

Query: 362  CK-VPNSRIP-TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRG 416
            C  +  + IP   W +    LL         +G+   L I R++  D G Y C    + G
Sbjct: 911  CTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS---LHIERVQLQDGGEYTCVASNVAG 967

Query: 417  RVRTVANVTVKG-PILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGEELP 469
                  +V V   P ++   + L  +EG     +  TL     G       WS+ GE + 
Sbjct: 968  TNNKTTSVVVHVLPTIQHGQQILSTIEG-----IPVTLPCKASGNPKPSVIWSKKGELIS 1022

Query: 470  V-ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP---------- 518
                + S+G   +L +     E++GE   +  N+      +V+   +  P          
Sbjct: 1023 TSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS 1082

Query: 519  -GPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEV 577
               P+   +  G + T+     P E     P I    ++      +    +   +G++++
Sbjct: 1083 QDKPVEISVLAGEEVTL-----PCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKI 1137

Query: 578  PGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSL 637
                    G Y   +C  +    +       + H+ P  ++  G + ++V  G+     +
Sbjct: 1138 TETRTSDSGMY---LCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQVGQ----RV 1188

Query: 638  DLSTIIQG------TW-------FLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH 684
            D+    QG      TW        ++GE   SN P+G +        I+Q       I  
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN-PDGTLS-------IDQATPSDAGIYT 1240

Query: 685  AVKHQDSGALVGFSCPGVQDSAALTIQESP-VHILSP------QDRVSLTFTTSERVVLT 737
             V    +G          +    L +QE P V  L P      Q+RV+     ++R+   
Sbjct: 1241 CVATNIAGT--------DETEITLHVQEPPTVEDLEPPYNTTFQERVA-----NQRIEFP 1287

Query: 738  CELSRVDFPA-TWYKDGQKVEESEL-LVVKMDGRKHRLILPEAKVQDSGEFEC----RTE 791
            C       P   W  +G+++   E  + +  DG    L++      D+GE+ C       
Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGREPGISILEDGT--LLVIASVTPYDNGEYICVAVNEAG 1345

Query: 792  GVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEES 850
                 + + V  PPV I D  +   V  + ++   L CEV+   +P + WYKD  +V ES
Sbjct: 1346 TTERKYNLKVHVPPV-IKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES 1404

Query: 851  DFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSWIVYPSGKV 906
              +   N G  + L L    P D G + C    +AG    YF + +  V   I+  +   
Sbjct: 1405 STIQTVNNG--KILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL-VPPTIIGTNFPN 1461

Query: 907  YVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEV-VESPALLLQKEDTVRRLVLPAVQLED 964
             V+ V    V L C++   P+ ++ W KDG+ + +  P + L     V  L L   +  D
Sbjct: 1462 EVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRND 1519

Query: 965  SGEYLCEIDD----ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV-LMCELSREDAP 1019
             G Y C + +    ++    +T+  PP   I   +  T I+V +  ++ L CE      P
Sbjct: 1520 KGRYQCTVSNAAGKQAKDIKLTIYIPP--SIKGGNVTTDISVLINSLIKLECETRGLPMP 1577

Query: 1020 -VRWYKDGLEV-EESEALVLERDGPRCRLVLPAAQPEDGGEFVCD----AGDDSAFFTVT 1073
             + WYKDG  +   S+AL +++      L +P AQ  D   + C     AG     F V 
Sbjct: 1578 AITWYKDGQPIMSSSQALYIDKGQ---YLHIPRAQVSDSATYTCHVANVAGTAEKSFHVD 1634

Query: 1074 VTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQV-RWYKDGLEVEASDALQLGAE 1132
            V  PP  I    A  L+        + L C+ A   S +  W KDG+ V+A+D +++ A 
Sbjct: 1635 VYVPP-MIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAG 1693

Query: 1133 GPTRTLTLPHAQPEDAGEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPG 1188
            G  + L +  AQ  D G+Y+C     A    I + V +  PP      ET  S   V   
Sbjct: 1694 G--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDET--SYFIVMVN 1749

Query: 1189 EPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
              + L C ++ +  P ++W  +G+ + E +G ++   G  R L I  A  ++ GLY C +
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNG--RKLVIAQAQVSNTGLYRCMA 1807

Query: 1248 GAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGE 1307
                G     F V V  PP    +  + +  V+  P   L+ + +   P   + W KD +
Sbjct: 1808 ANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA-LQCIAN-GIPNPSITWLKDDQ 1865

Query: 1308 RL-ASQGRVQLEQAGARQVLRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKL 1362
             +  +QG ++++ +G  +VL++      DAG Y C     A +  +   + V EP  ++ 
Sbjct: 1866 PVNTAQGNLKIQSSG--RVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLED 1923

Query: 1363 VSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGC 1421
              ++   TV   +     C+ +  P   +TW ++  +++    +     G  +I+ +   
Sbjct: 1924 AGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRG--QIIDIESA 1981

Query: 1422 QLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQD----------VCLEVE 1471
            Q+ DAG     A ++A +       TEL +  ++    +  G +          V LE E
Sbjct: 1982 QISDAGIYKCVAINSAGA-------TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECE 2034

Query: 1472 TGRVGAAGAVRWVRGGQPLPHDSR-LSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTL 1530
               +  A ++ W++ G P+   S  L +   G I  L +    ++D G Y C + +    
Sbjct: 2035 ARGI-PAPSLTWLKDGSPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVN---A 2088

Query: 1531 ARLSVRPRQLRVLRPL----EDVTISEGGSATFQLELSQEGV---TGEWARGGVQLYPGP 1583
            A    R   LRV  P     E+  +S   S   +L    + +   T  W + G  L   P
Sbjct: 2089 AGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKP 2148

Query: 1584 KCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPH------- 1636
               I    +R  L +    + D+G   +T ++   A +   +   V I   P+       
Sbjct: 2149 GLSISE--NRSVLKIEDAQVQDTG--RYTCEATNVAGK-TEKNYNVNIWVPPNIGGSDEL 2203

Query: 1637 -DLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSD 1694
              L V EG+  +  CE S     ++ W+K G+ +      R++ L   R LQ+     SD
Sbjct: 2204 TQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSD 2263

Query: 1695 AGTYSC----AVGTARAG-PVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEV-ETT 1748
            A  YSC      GTA+    +++ +R       S    +    G   + EC V  +   T
Sbjct: 2264 AALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPT 2323

Query: 1749 GRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVE 1804
              W   G PL     V I  EG  HIL L  +   D G         AG       L V 
Sbjct: 2324 VTWMKDGHPLIKAKGVEILDEG--HILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVH 2381

Query: 1805 ALPLQMCRHPPREKTVLVGRRAVLEVTVSRSG---GHVCWLREGAELCPGDKYEMRSHGP 1861
            A P  +  H   E   +V + +V  +T   SG     + W ++G  +   +   + S G 
Sbjct: 2382 APPSIIGNHRSPENISVVEKNSV-SLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGG- 2439

Query: 1862 THSLVIHDVRPEDQGTYCC 1880
               L +     ED G Y C
Sbjct: 2440 -RMLRLMQTTMEDAGQYTC 2457



 Score =  269 bits (687), Expect = 2e-71
 Identities = 469/2025 (23%), Positives = 751/2025 (37%), Gaps = 300/2025 (14%)

Query: 10   SPPCFL---RFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
            +PP  +   R P  + VV      L C   G P P + W K G  ++ S  +   + G  
Sbjct: 2382 APPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM 2441

Query: 67   HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP--ASDPELQPAERPLPSPGSG 124
              L+ T     DAG Y C  RNAAGE      ++VL PP    +  L+  +         
Sbjct: 2442 LRLMQTTM--EDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVK--------- 2490

Query: 125  EGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA 184
                          V     V LTC   G P P + W KDG  L E  D +H  +  GR 
Sbjct: 2491 --------------VKEKQSVTLTCEVTGNPVPEITWHKDGQPLQE--DEAHHIISGGRF 2534

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPV 244
                     L+I   ++P +G Y C A +  GH      L V   P       D  P  V
Sbjct: 2535 ---------LQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVL 304
               L                  C     P   I W  +G PL  +R     R   GG  L
Sbjct: 2586 TVILNSPTSLV-----------CEAYSYPPATITWFKDGTPLESNRN---IRILPGGRTL 2631

Query: 305  KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPL-------QDVEGREHGI 357
            ++L  Q  + G Y C A N AG+ +   ++ V  P +     L       ++V+ + +  
Sbjct: 2632 QILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNT 2691

Query: 358  AVLECK---VPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC-- 412
              LEC+   +P++ +  +W+++ Q L           G    L I   +  D G Y C  
Sbjct: 2692 LTLECEAYAIPSASL--SWYKDGQPLKSDDHVNIAANG--HTLQIKEAQISDTGRYTCVA 2747

Query: 413  -EMRGRVRTVANVTVKGPI-------------LKRLPRKLDVLEGENAVLLVETLEAGVE 458
              + G      +V ++ P                R     DV+      L  ET  A   
Sbjct: 2748 SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPP 2807

Query: 459  G-RWSRDGEELPVICQSSSGHMHALVLPG--------VTREDAGEVTFSLGNSRTTTLLR 509
               W +DG  L     +SS  +  L+LPG           EDAG  T    N      L+
Sbjct: 2808 TLTWYKDGHPL-----TSSDKV--LILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQ 2860

Query: 510  VKCVKHSPPGPPILAEMFKG-------------HKNTVLLTWKPPEPAPETPFIYRLERQ 556
                   PP       + KG             +K+ ++       PAP     ++ + Q
Sbjct: 2861 YDVRVLVPP-------IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNS--WQKDGQ 2911

Query: 557  EVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTA 616
             +  +D  +  S      +++    +   G Y   +C       S    F+ + H VP +
Sbjct: 2912 PLLEDDHHKFLS--NGRILQILNTQITDIGRY---VCVAENTAGSAKKYFNLNVH-VPPS 2965

Query: 617  RLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELKSNEPEGQVEPGALRYRIEQ 674
             +    E++ V        + ++S       +W  N + +K N     + PG    +I +
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNT-NTLIVPGGRTLQIIR 3024

Query: 675  KGLQHRLILHAVKHQDSGALVGFSCPGVQDSA------ALTIQESPVHILSPQDRVSLTF 728
                        K  D G    ++C  +  +       +LT+   P   +   D  SL+ 
Sbjct: 3025 -----------AKVSDGGE---YTCIAINQAGESKKKFSLTVYVPPS--IKDHDSESLSV 3068

Query: 729  TTSER---VVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
                    V L CE + V  P  TWYK+G+ + ES  + +  DG+   L + +A+V D+G
Sbjct: 3069 VNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQM--LHIKKAEVSDTG 3126

Query: 785  EFECRTEGVSAF----FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VR 839
            ++ CR   V+      F + V  PP  I  P   V V  I++  V L C+      P + 
Sbjct: 3127 QYVCRAINVAGRDDKNFHLNVYVPP-SIEGPEREVIVETISNP-VTLTCDATGIPPPTIA 3184

Query: 840  WYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD------ECAYFTVTIT 893
            W K+ + +E SD + +       +L +  +Q SD G + C+A +      +  + ++ + 
Sbjct: 3185 WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP 3244

Query: 894  DVSSWIVYPSGKVYVAAVRLERVVLTCELCR-PWAEVRWTKDGEEVVESPALLLQKEDTV 952
               +    PS    V+ +  E V L C     P   ++W KDG+ +       ++     
Sbjct: 3245 PSVAGAEIPSD---VSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG 3301

Query: 953  RRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV 1008
              L +      D+G+Y C       +E   F + V   P  I   +DE   +   ++  +
Sbjct: 3302 STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPT-IRGNKDEAEKLMTLVDTSI 3360

Query: 1009 -LMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----D 1062
             + C  +    P + W K+GL +  S  + L   G   R+V   AQ  D   + C     
Sbjct: 3361 NIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIV--RAQVSDVAVYTCVASNR 3418

Query: 1063 AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVE 1122
            AG D+  + + V APP          + +  G+   +    +  PA S   W +DG  + 
Sbjct: 3419 AGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMA-WLRDGQPLG 3477

Query: 1123 ASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA--ITFNVILA--EPPVQFLALET 1178
                L +   G    L L  A+ ED+G+Y C   +EA  ++ + IL   EPP   +    
Sbjct: 3478 LDAHLTVSTHG--MVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP--HINGSE 3533

Query: 1179 TPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGP 1237
                + V    P+ L+C  S   AP + W  +GRP+ + +  ++   G   VL I  A  
Sbjct: 3534 EHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTD--QVQTLGGGEVLRISTAQV 3591

Query: 1238 AHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG 1297
               G YTC + +  G     + V+V  PP      E     V       LE     + P 
Sbjct: 3592 EDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSD-AVPP 3650

Query: 1298 GPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAP----QDSRIFLVS 1353
              + W ++GERL +  RV++   G  + L++  A  GD   Y C A     + +R F+++
Sbjct: 3651 PVITWLRNGERLQATPRVRILSGG--RYLQINNADLGDTANYTCVASNIAGKTTREFILT 3708

Query: 1354 VEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPG-PQVEMAQNGS 1412
            V  P  +K   +   + +++        E   P   +TW ++GAV+     +  + +NG 
Sbjct: 3709 VNVPPNIKGGPQSLVILLNKSTVLECIAE-GVPTPRITWRKDGAVLAGNHARYSILENG- 3766

Query: 1413 SRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVET 1472
               L ++   + D G     A + A + R   R  +L                V + V+T
Sbjct: 3767 --FLHIQSAHVTDTGRYLCMATNAAGTDR---RRIDLQVHVPPSIAPGPTNMTVIVNVQT 3821

Query: 1473 GRVGAAG-----AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILA------DQGTYG 1521
                 A      ++ W + G  L  D      Q+ + +RL   G ++       D  TY 
Sbjct: 3822 TLACEATGIPKPSINWRKNGHLLNVD------QNQNSYRLLSSGSLVIISPSVDDTATYE 3875

Query: 1522 CE----SHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTG-EWARGG 1576
            C     +  D+    L+V+        P  D  +++   A      S        W + G
Sbjct: 3876 CTVTNGAGDDKRTVDLTVQVPPSIADEPT-DFLVTKHAPAVITCTASGVPFPSIHWTKNG 3934

Query: 1577 VQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLR------CAAR--------- 1621
            ++L P        DG+R         +  SG +   A  L       C AR         
Sbjct: 3935 IRLLP------RGDGYR---------ILSSGAIEILATQLNHAGRYTCVARNAAGSAHRH 3979

Query: 1622 --LIVREVPVTIVRGPHDLEVTEGDTATFECELSQALAD-VTWEKDGNALTPSPRLRLQA 1678
              L V E PV I   P +L V   +     CE +   +  +TW+K+G  +  S R    A
Sbjct: 3980 VTLHVHEPPV-IQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNH--A 4036

Query: 1679 LGTRRLLQLRRCGPSDAGTYSCAV----GTARAGPVRLTVRERTVAVLSELRSVSAREGD 1734
            +     LQ+ R    DAGTY C      GTA  G ++L V+   V +   L+        
Sbjct: 4037 VLPSGGLQISRAVREDAGTYMCVAQNPAGTA-LGKIKLNVQVPPV-ISPHLKEYVIAVDK 4094

Query: 1735 GATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA- 1792
              T  C    +      W   GR +    R R+   G    L ++ ++  DAG     A 
Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGS---LQIAFVQPGDAGHYTCMAA 4151

Query: 1793 ---GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLE-VTVSRSGGHVCWLREGAEL 1848
               G + +   L V   P    R      TV    +A+L  V        + W ++   L
Sbjct: 4152 NVAGSSSTSTKLTVHVPP--RIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLL 4209

Query: 1849 CPG-DKYEMRSHGPTHSLVIHDVRPEDQGTYCC---QAGQDSTHT 1889
                 KY    +G    L++ +V  ED G Y C    A  + THT
Sbjct: 4210 ANLLGKYTAEPYG---ELILENVVLEDSGFYTCVANNAAGEDTHT 4251



 Score =  263 bits (672), Expect = 1e-69
 Identities = 466/2028 (22%), Positives = 763/2028 (37%), Gaps = 311/2028 (15%)

Query: 7    DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
            D GSPP F++ P  V +  G+   L C V G P P + W    ++L      S P   + 
Sbjct: 788  DVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW----RRLDNMPIFSRPFSVSS 843

Query: 67   HGLLLTAAL------PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS 120
               L T AL       +D G Y+C A N  G+  +   VTV                   
Sbjct: 844  ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV------------------- 884

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCR-AGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
              +G  AP+    P    V+ G ++ L C    G P P   W K+   L     + +  +
Sbjct: 885  --TGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML---LQNPYITV 939

Query: 180  QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE 239
            +     DG     +L I   +L D G Y C A N  G       + VH            
Sbjct: 940  R----SDG-----SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVH------------ 978

Query: 240  APAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRD 299
                V+  ++   +     EG      C   G P+P + W  +G  L+           D
Sbjct: 979  ----VLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGE-LISTSSAKFSAGAD 1033

Query: 300  GGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIA- 358
            G   L V+    ++ G YVC A N+AG     VQL V      + RP   V G + G++ 
Sbjct: 1034 GS--LYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV------YVRP--RVFGDQRGLSQ 1083

Query: 359  --------------VLECKVPNSRIP-TAWFREDQRLLP-CRKYEQIEEGTVRRLIIHRL 402
                           L C+V +   P   W +E Q + P   ++  +  G+++   I   
Sbjct: 1084 DKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMK---ITET 1140

Query: 403  KADDDGIYLC---EMRGRVRTVANVTVK-GPILKRLPRKLDVLEGENAVLLVETLEAGVE 458
            +  D G+YLC    + G V     + V   P ++R P+ L V  G+            V+
Sbjct: 1141 RTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQR-----------VD 1189

Query: 459  GRWSRDGEELPVICQSSSG---------HMH----ALVLPGVTREDAGEVTFSLGNSRTT 505
               +  G  LPVI  S  G         H+      L +   T  DAG  T    N   T
Sbjct: 1190 IPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGT 1249

Query: 506  TLLRVKCVKHSPPG----PPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLE--RQEVG 559
                +      PP      P     F+       + +  P      P I  L   R+  G
Sbjct: 1250 DETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTG 1309

Query: 560  SEDWIQCFSIEKAGAVEVPGDCVP-SEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARL 618
             E  I   SI + G + V     P   G+Y   IC       +    ++   H+ P  + 
Sbjct: 1310 REPGI---SILEDGTLLVIASVTPYDNGEY---ICVAVNEAGTTERKYNLKVHVPPVIKD 1363

Query: 619  VAGLEDVQVYDGEDAVFSLDLSTIIQGT------WFLNGEELKSNEPEGQVEPGALRYRI 672
               + +V V   +      +L   ++GT      W+ +  ++  +     V  G +    
Sbjct: 1364 KEQVTNVSVLLNQ----LTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKI---- 1415

Query: 673  EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
                    L L     +D+G    +SC  + + A  + +   + +L P   +   F    
Sbjct: 1416 --------LKLFRATPEDAGR---YSCKAI-NIAGTSQKYFNIDVLVPPTIIGTNFPNEV 1463

Query: 733  RVVLT------CELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGE 785
             VVL       C++    FP   W+KDG+ +   +  V  +D R   L L  A+  D G 
Sbjct: 1464 SVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGR 1522

Query: 786  FECRTEGVSA----FFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRW 840
            ++C     +        +T+  PP  I        +  + +  + L CE      P + W
Sbjct: 1523 YQCTVSNAAGKQAKDIKLTIYIPP-SIKGGNVTTDISVLINSLIKLECETRGLPMPAITW 1581

Query: 841  YKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTI---T 893
            YKDGQ +  S   +  ++G +  L +P  Q SD   + C    VAG     F V +    
Sbjct: 1582 YKDGQPIMSSSQALYIDKGQY--LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP 1639

Query: 894  DVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTV 952
             +   +  P  K  V A     + L C+    P   + W KDG  V  +  + +  E   
Sbjct: 1640 MIEGNLATPLNKQVVIA---HSLTLECKAAGNPSPILTWLKDGVPVKANDNIRI--EAGG 1694

Query: 953  RRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV 1008
            ++L + + Q  D G+Y+C       ++   + V V  PP   I   DE +   V +  ++
Sbjct: 1695 KKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPA--IEGGDETSYFIVMVNNLL 1752

Query: 1009 -LMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----D 1062
             L C ++    P + W KDG  ++E +   +  +G   +LV+  AQ  + G + C     
Sbjct: 1753 ELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGR--KLVIAQAQVSNTGLYRCMAANT 1810

Query: 1063 AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEV-APAGSQVRWYKDGLEV 1121
            AGD    F VTV  PP       +  + + +     V L+C         + W KD   V
Sbjct: 1811 AGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKP---VALQCIANGIPNPSITWLKDDQPV 1867

Query: 1122 EASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA----ITFNVILAEPPVQFLALE 1177
              +    L  +   R L +     EDAG Y C   + A        + + EPP    +LE
Sbjct: 1868 NTAQG-NLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPP----SLE 1922

Query: 1178 TTPSPL--CVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQA 1234
                 L   V    PV L C+ +    PV+ W  + R +     +     G  +++ I++
Sbjct: 1923 DAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRG--QIIDIES 1980

Query: 1235 AGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLS 1294
            A  + AG+Y C +  + GA  L +++QV   P    +   +   V       + L     
Sbjct: 1981 AQISDAGIYKCVAINSAGATELFYSLQVHVAP----SISGSNNMVAVVVNNPVRLECEAR 2036

Query: 1295 G-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQ-------- 1345
            G P   + W KDG  ++S        +G R +L +  A+  D G Y C A          
Sbjct: 2037 GIPAPSLTWLKDGSPVSSFSNGLQVLSGGR-ILALTSAQISDTGRYTCVAVNAAGEKQRD 2095

Query: 1346 -DSRIFL---VSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP 1401
             D R+++   +  EE  +  L+S+   L      DA     + PP   +TWL++G  +  
Sbjct: 2096 IDLRVYVPPNIMGEEQNVSVLISQAVELLCQ--SDA-----IPPP--TLTWLKDGHPLLK 2146

Query: 1402 GPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTA--TSARLHVR---ETELLFLRRLQ 1456
             P + +++N S  +L +   Q+ D G  T  A + A  T    +V       +     L 
Sbjct: 2147 KPGLSISENRS--VLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT 2204

Query: 1457 DVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDS--RLSMAQDGHIHRLFIHGVIL 1514
             +   EG  + L  E+  +     + W + G P+  DS  R+ +   G   +L I     
Sbjct: 2205 QLTVIEGNLISLLCESSGIPPPNLI-WKKKGSPVLTDSMGRVRILSGG--RQLQISIAEK 2261

Query: 1515 ADQGTYGCESHHDRTLAR------LSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
            +D   Y C + +    A+      + +RP          ++ ++ G S + + E+  +G+
Sbjct: 2262 SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV--QGI 2319

Query: 1569 ---TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSFTADSLRCAARL 1622
               T  W + G  L       I  +G  H L L  + ++D+G   CV+     +      
Sbjct: 2320 PPPTVTWMKDGHPLIKAKGVEILDEG--HILQLKNIHVSDTGRYVCVAVNVAGMTDKKYD 2377

Query: 1623 IVREVPVTIV---RGPHDLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQA 1678
            +    P +I+   R P ++ V E ++ +  CE S   L  +TW KDG  ++ S  +R+ +
Sbjct: 2378 LSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILS 2437

Query: 1679 LGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVR------LTVRERTVAVLSELRSVSARE 1732
             G  R+L+L +    DAG Y+C V  A AG  R      + V    V   + L  V  +E
Sbjct: 2438 GG--RMLRLMQTTMEDAGQYTCVVRNA-AGEERKIFGLSVLVPPHIVGE-NTLEDVKVKE 2493

Query: 1733 GDGATFECTVSEVETTGR------WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG 1786
                T  C     E TG       W   G+PL+      I   G+   L ++ ++    G
Sbjct: 2494 KQSVTLTC-----EVTGNPVPEITWHKDGQPLQEDEAHHIISGGR--FLQITNVQVPHTG 2546

Query: 1787 E----VRFQAGPAQSLALLEVEALP----LQMCRHPPREKTVLVGRRAVLEVTVSRSGGH 1838
                     AG       L V   P    +    +P     +L    +++    S     
Sbjct: 2547 RYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPAT 2606

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDS 1886
            + W ++G  L       +   G T  L I + + ++ G Y C A  ++
Sbjct: 2607 ITWFKDGTPLESNRNIRILPGGRT--LQILNAQEDNAGRYSCVATNEA 2652



 Score =  261 bits (667), Expect = 5e-69
 Identities = 447/1894 (23%), Positives = 710/1894 (37%), Gaps = 267/1894 (14%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
            V+      L C     PPP + W K G  L +S+++     G    L +  A   DAG Y
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRV--LQIPRAKVEDAGRY 2846

Query: 83   VCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRG 142
             C A N AGE      V VL PP     ++ A   LP   +               VL  
Sbjct: 2847 TCVAVNEAGEDSLQYDVRVLVPPI----IKGANSDLPEEVT---------------VLVN 2887

Query: 143  AEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLP 202
               ++ C + G P P   W+KDG  L E  D  H  L  GR          L+IL  ++ 
Sbjct: 2888 KSALIECLSSGSPAPRNSWQKDGQPLLE--DDHHKFLSNGRI---------LQILNTQIT 2936

Query: 203  DSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKH 262
            D G YVC A N  G A+    L VH PP             V+ P K    T  VN    
Sbjct: 2937 DIGRYVCVAENTAGSAKKYFNLNVHVPPS------------VIGP-KSENLTVVVNN--F 2981

Query: 263  AKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
                C V G P P++ W    +P+  +   L+     GG  L+++  +  D G Y C A 
Sbjct: 2982 ISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIV---PGGRTLQIIRAKVSDGGEYTCIAI 3038

Query: 323  NSAGQTLSAVQLHVKEP---RLRFTRPLQDVEGREHGIAVLECKVPNSRIPT---AWFRE 376
            N AG++     L V  P   +   +  L  V  RE     LEC+  ++ +P     W++ 
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECE--SNAVPPPVITWYKN 3096

Query: 377  DQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPR 436
             + +      E + +G +  L I + +  D G Y+C           + V G   K    
Sbjct: 3097 GRMITESTHVEILADGQM--LHIKKAEVSDTGQYVCRA---------INVAGRDDKNFHL 3145

Query: 437  KLDV---LEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTREDAG 493
             + V   +EG    ++VET+   V       G   P I    +          +   D+ 
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKR-------IENSDSL 3198

Query: 494  EVTFSLGNSRTTTLLRVKCVKHSPPGP-PILAEMFKG--HKNTVLLTWKPPEPAPE---- 546
            EV    G S+    L++   +HS  G    +A   +G   K   L    PP  A      
Sbjct: 3199 EVRILSGGSK----LQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPS 3254

Query: 547  --------------------TPFIYRL-ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSE 585
                                TP I  L + + + S +  +         + + G      
Sbjct: 3255 DVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDT 3314

Query: 586  GDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQ- 644
            G Y    C  +        +F+ + ++ PT R   G +D    + E  +  +D S  I+ 
Sbjct: 3315 GKYT---CVATNPAGEEDRIFNLNVYVTPTIR---GNKD----EAEKLMTLVDTSINIEC 3364

Query: 645  ---GT------WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALV 695
               GT      W  NG  L          P +   R+   G   R++   V        V
Sbjct: 3365 RATGTPPPQINWLKNGLPL----------PLSSHIRLLAAGQVIRIVRAQVSDVAVYTCV 3414

Query: 696  GFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQ 754
              +  GV +        +P ++ +      +T        + C       P+  W +DGQ
Sbjct: 3415 ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474

Query: 755  KVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVD 810
             +     L V   G   +L+  +A+ +DSG++ C        VS  F + V +PP HI  
Sbjct: 3475 PLGLDAHLTVSTHGMVLQLL--KAETEDSGKYTCIASNEAGEVSKHFILKVLEPP-HING 3531

Query: 811  PREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPAT 869
              EH  +  I +  + L C      AP + W KDG+ + ++D V  +  G    L +   
Sbjct: 3532 SEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQV--QTLGGGEVLRISTA 3589

Query: 870  QPSDGGEFQCVA----GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL-CR 924
            Q  D G + C+A    GD+   + V +  V   I        +  +R  +V L C+    
Sbjct: 3590 QVEDTGRYTCLASSPAGDDDKEYLVRV-HVPPNIAGTDEPRDITVLRNRQVTLECKSDAV 3648

Query: 925  PWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD----ESASFT 980
            P   + W ++GE +  +P + +      R L +    L D+  Y C   +     +  F 
Sbjct: 3649 PPPVITWLRNGERLQATPRVRILSGG--RYLQINNADLGDTANYTCVASNIAGKTTREFI 3706

Query: 981  VTVTEPPVRIIYPRDEVTLI--AVTLECVVLMCELSREDAPVRWYKDGLEVEESEAL--V 1036
            +TV  PP     P+  V L+  +  LEC+       R    + W KDG  +  + A   +
Sbjct: 3707 LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPR----ITWRKDGAVLAGNHARYSI 3762

Query: 1037 LERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLH 1092
            LE       L + +A   D G ++C     AG D     + V  PP     P   ++ ++
Sbjct: 3763 LENGF----LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVN 3818

Query: 1093 FGAPGRVELRCEVAPAGS-QVRWYKDG--LEVEAS-DALQLGAEGPTRTLTLPHAQPEDA 1148
                 +  L CE        + W K+G  L V+ + ++ +L + G   +L +     +D 
Sbjct: 3819 V----QTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSG---SLVIISPSVDDT 3871

Query: 1149 GEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV 1204
              Y C   + A     T ++ +  PP    ++   P+   V    P V++C  S    P 
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPP----SIADEPTDFLVTKHAPAVITCTASGVPFPS 3927

Query: 1205 V-WSHNG-RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQV 1262
            + W+ NG R +  G+G  + + G   +L  Q     HAG YTC +  A G+     T+ V
Sbjct: 3928 IHWTKNGIRLLPRGDGYRILSSGAIEILATQLN---HAGRYTCVARNAAGSAHRHVTLHV 3984

Query: 1263 AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGR--VQLEQ 1319
             EPP  V+ P+ ++  V       + L    +G   P + W K+G  + + GR    L  
Sbjct: 3985 HEPP--VIQPQPSELHV--ILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPS 4040

Query: 1320 AGARQVLRVQGARSGDAGEYLCDA--PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDA 1377
             G    L++  A   DAG Y+C A  P  + +  + +   +   +   L    +      
Sbjct: 4041 GG----LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096

Query: 1378 TFRCEVSP-PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR---- 1432
            T  CE    P  D+TW ++G  +    +  +  +GS +I  +   Q GDAG  T      
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFV---QPGDAGHYTCMAANV 4153

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
            AGS++TS +L V     +          E  Q +   V  G      A+ W +    L  
Sbjct: 4154 AGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGI--PTPAINWKKDNVLLA- 4210

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHH----DRTLARLSVRPRQLRVLRPLED 1548
             + L          L +  V+L D G Y C +++    D     L+V         P  D
Sbjct: 4211 -NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP-GD 4268

Query: 1549 VTISEGGSATFQLELSQEGVTG------EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
            V++++G     QL LS +  TG       W      + P    H  S      LV+  + 
Sbjct: 4269 VSLNKGE----QLRLSCK-ATGIPLPKLTWTFNN-NIIP---AHFDSVNGHSELVIERVS 4319

Query: 1603 LADSGCVSFTADS----LRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECEL-SQALA 1657
              DSG    TA++    ++    + V+E PV     P +     G  A   CE+      
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTP 4379

Query: 1658 DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVR----LT 1713
             + W + G  +  S R+R    G+   L +      DAG Y+C V T  AG V     LT
Sbjct: 4380 TIQWNRKGVDIEISHRIRQLGNGS---LAIYGTVNEDAGDYTC-VATNEAGVVERSMSLT 4435

Query: 1714 VRERTVAVLSELRSVSAREGDGATFEC-TVSEVETTGRWELGGRPLRPGARVRIRQEGKK 1772
            ++   +  L  + +V    G      C    E + T  W   G  +    RV +      
Sbjct: 4436 LQSPPIITLEPVETV-INAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS- 4493

Query: 1773 HILVLSELRAEDAGEVRFQAGPAQSLALLEVEAL 1806
              L +++ + ED  E    A       L+ V  +
Sbjct: 4494 --LYIADAQKEDTSEFECVARNLMGSVLVRVPVI 4525



 Score =  256 bits (654), Expect = 1e-67
 Identities = 468/1993 (23%), Positives = 744/1993 (37%), Gaps = 259/1993 (12%)

Query: 7    DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPA---D 63
            D   PP  ++ P  V V  G  A L C+++      + W++  + +    RL+ PA    
Sbjct: 515  DVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDV----RLAEPARIRT 570

Query: 64   GAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGS 123
             A   L L +    DAG Y C   +  G + A+  +TV EPP                  
Sbjct: 571  LANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPK----------------- 613

Query: 124  GEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGR 183
                      P++Q    G+EV + C A G P+P + W  + M +      SH   +   
Sbjct: 614  ------VTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI----VGSH---RYRM 660

Query: 184  AEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAP 243
              DG      L I  A   D+G+Y C A N+ G  +  + L+  + P+            
Sbjct: 661  TSDG-----TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPK------------ 703

Query: 244  VVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFV 303
                L        V  G      C   G P P+++W      L P     +  D   G +
Sbjct: 704  ----LMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPS--TFLIIDPLLG-L 756

Query: 304  LKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECK 363
            LK+   Q  D G Y C A N AG+    + L V  P +    P  DV         L C 
Sbjct: 757  LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEP-ADVSMEIGSNVTLPCY 815

Query: 364  VPNSRIPT-AWFREDQRLLPCRKY--EQIEEGTVRRLIIHRLKADDDGIYLCEMR---GR 417
            V     PT  W R D   +  R +    I +     L I  L A D G Y+CE     G+
Sbjct: 816  VQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK 875

Query: 418  VRTVANVTVKG---PILKRLPRKLDVLEGENAVLLVETLEAG---VEGRWSRDGEEL--- 468
            +++   VTV G   P++   P   +V+EG+   L   TL AG    E RW ++   L   
Sbjct: 876  IQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPC-TLLAGNPIPERRWIKNSAMLLQN 934

Query: 469  PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP----GPPILA 524
            P I   S G +H   +  V  +D GE T    N   T       V H  P    G  IL+
Sbjct: 935  PYITVRSDGSLH---IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILS 991

Query: 525  EMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPS 584
             +       + +T          P +   ++ E+ S    + FS    G++ V       
Sbjct: 992  TI-----EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAK-FSAGADGSLYVVSPGGEE 1045

Query: 585  EGDYRFRICTVSGHG-RSPHVVFHGSAHLVPTARLVAGLE-----DVQVYDGEDAVFSLD 638
             G+Y       +G+  R   +  +    +    R   GL      ++ V  GE+     +
Sbjct: 1046 SGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQR---GLSQDKPVEISVLAGEEVTLPCE 1102

Query: 639  LSTIIQG--TWFLNGEELKSNEPEGQVEP-GALRY---RIEQKGLQHRLILHAVKHQDSG 692
            + ++     TW    + +    P     P G+++    R    G+   +  +   +    
Sbjct: 1103 VKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQA 1162

Query: 693  ALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYK 751
              +    P         IQ  P H         L     +RV + C       P  TW K
Sbjct: 1163 VKLNVHVPP-------KIQRGPKH---------LKVQVGQRVDIPCNAQGTPLPVITWSK 1206

Query: 752  DGQ-KVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF----FGVTVQDPPV 806
             G   + + E  V   DG    L + +A   D+G + C    ++        + VQ+PP 
Sbjct: 1207 GGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPT 1263

Query: 807  --HIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEV--EESDFVVLENEGPH 861
               +  P    F   + ++ +   C       P ++W  +G+E+   E    +LE+    
Sbjct: 1264 VEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILED---G 1320

Query: 862  RRLVLPATQPSDGGEFQCVAGDECAYF--TVTITDVSSWIVYPSGKVYVAAVRLERVV-L 918
              LV+ +  P D GE+ CVA +E         +      ++    +V   +V L ++  L
Sbjct: 1321 TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNL 1380

Query: 919  TCEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESA 977
             CE+   P   + W KD  +V ES    +Q  +  + L L     ED+G Y C+  + + 
Sbjct: 1381 FCEVEGTPSPIIMWYKDNVQVTESST--IQTVNNGKILKLFRATPEDAGRYSCKAINIAG 1438

Query: 978  S----FTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDG--LEVE 1030
            +    F + V  PP  II       +  V    V L C++     P + W+KDG  L + 
Sbjct: 1439 TSQKYFNIDVLVPPT-IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG 1497

Query: 1031 ESEALVLERDGPRCRLVLPAAQPEDGGEFVCD----AGDDSAFFTVTVTAPPERIVHPAA 1086
            +    +L+R      L L  A+  D G + C     AG  +    +T+  PP   +    
Sbjct: 1498 DPNVELLDRGQV---LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPS--IKGGN 1552

Query: 1087 RSLDLHFGAPGRVELRCEV----APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPH 1142
             + D+       ++L CE      PA   + WYKDG  + +S       +G  + L +P 
Sbjct: 1553 VTTDISVLINSLIKLECETRGLPMPA---ITWYKDGQPIMSSSQALYIDKG--QYLHIPR 1607

Query: 1143 AQPEDAGEYVCETRHEAIT----FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELS 1198
            AQ  D+  Y C   + A T    F+V +  PP+    L  TP    V     + L C+ +
Sbjct: 1608 AQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNL-ATPLNKQVVIAHSLTLECKAA 1666

Query: 1199 RAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLS 1257
               +P++ W  +G PV+  + + + A G +  L I +A     G Y C + +  G   + 
Sbjct: 1667 GNPSPILTWLKDGVPVKANDNIRIEAGGKK--LEIMSAQEIDRGQYICVATSVAGEKEIK 1724

Query: 1258 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQ 1316
            + V V  PP      E +   V       LEL  H++G P   + W KDG+ +  +   +
Sbjct: 1725 YEVDVLVPPAIEGGDETSYFIV--MVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFK 1782

Query: 1317 LEQAGARQVLRVQGARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVH 1372
            +   G + V  +  A+  + G Y C     A    + F V+V  P  +K  S L+   V 
Sbjct: 1783 ILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIK-SSGLSERVVV 1839

Query: 1373 EGDDATFRCEVSP-PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAG---- 1427
            +      +C  +  P+  +TWL++   V    Q  +    S R+L +    L DAG    
Sbjct: 1840 KYKPVALQCIANGIPNPSITWLKDDQPVNTA-QGNLKIQSSGRVLQIAKTLLEDAGRYTC 1898

Query: 1428 TVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVC----LEVETGRVG-AAGAVR 1482
              T  AG T    +LHV E        L+D      + V     +++E    G     + 
Sbjct: 1899 VATNAAGETQQHIQLHVHEPP-----SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVIT 1953

Query: 1483 WVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRV 1542
            W +  + L   + ++    G I  + I    ++D G Y C + +      L      L+V
Sbjct: 1954 WYKDNRLLSGSTSMTFLNRGQI--IDIESAQISDAGIYKCVAINSAGATELFY---SLQV 2008

Query: 1543 LRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
                  V  S  GS      +    V  E    G+   P P      DG       NGL 
Sbjct: 2009 -----HVAPSISGSNNMVAVVVNNPVRLECEARGI---PAPSLTWLKDGSPVSSFSNGLQ 2060

Query: 1603 LADSG-----------------CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT 1645
            +   G                 CV+  A   +     +   VP  I+    ++ V     
Sbjct: 2061 VLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120

Query: 1646 ATFECELSQAL--ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC--- 1700
                C+ S A+    +TW KDG+ L   P L +     R +L++      D G Y+C   
Sbjct: 2121 VELLCQ-SDAIPPPTLTWLKDGHPLLKKPGLSISE--NRSVLKIEDAQVQDTGRYTCEAT 2177

Query: 1701 --AVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGR-WELGGRP 1757
              A  T +   V + V    +    EL  ++  EG+  +  C  S +      W+  G P
Sbjct: 2178 NVAGKTEKNYNVNIWV-PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSP 2236

Query: 1758 LRPGA--RVRIRQEGKKHILVLSELRAEDAG----EVRFQAGPAQSLALLEVEALP-LQM 1810
            +   +  RVRI   G++  L +S     DA          AG A+    L+V   P +  
Sbjct: 2237 VLTDSMGRVRILSGGRQ--LQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITN 2294

Query: 1811 CRHPPREKTVLVGRRAVLEVTVSR-SGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHD 1869
                P E  V  G+   LE  V       V W+++G  L      E+   G  H L + +
Sbjct: 2295 SGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEG--HILQLKN 2352

Query: 1870 VRPEDQGTYCCQA 1882
            +   D G Y C A
Sbjct: 2353 IHVSDTGRYVCVA 2365



 Score =  215 bits (548), Expect = 3e-55
 Identities = 410/1874 (21%), Positives = 701/1874 (37%), Gaps = 256/1874 (13%)

Query: 30   ELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNA 89
            ++ C V    P  + + + G  L   + L    + A   L +     +D G Y C A ++
Sbjct: 448  QIPCSVDSLLPFTLSFVRNGVTLGVDQYLK---ESASVNLDIAKVTLSDEGFYECIAVSS 504

Query: 90   AGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTC 149
            AG   A     V EPP   P +Q                     P +  V  G   VLTC
Sbjct: 505  AGTGRAQTFFDVSEPP---PVIQV--------------------PNNVTVTPGERAVLTC 541

Query: 150  RAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVC 209
                  +  L W+++        D      +P R      A+L+L + + +  D+G Y C
Sbjct: 542  LIISAVDYNLTWQRN--------DRDVRLAEPARIRTL--ANLSLELKSVKFNDAGEYHC 591

Query: 210  HARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYV 269
               +  G + A   L V +PP+                +   PK      G      C  
Sbjct: 592  MVSSEGGSSAASVFLTVQEPPK----------------VTVMPKNQSFTGGSEVSIMCSA 635

Query: 270  MGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG-QT 328
             G P+P+I W      ++   R  M  D      L +     KD G+Y C A NSAG   
Sbjct: 636  TGYPKPKIAWTVNDMFIVGSHRYRMTSDG----TLFIKNAAPKDAGIYGCLASNSAGTDK 691

Query: 329  LSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRKYE 387
             ++   +++ P+L   +   ++      I V+ECK      P   WF+ D  L P     
Sbjct: 692  QNSTLRYIEAPKLMVVQ--SELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFL- 748

Query: 388  QIEEGTVRRLIIHRLKADDDGIYLC-EMRGRVRTVANVTV---KGPILKRLPRKLDVLEG 443
             I +  +  L I   +  D G Y C  +    R    +T+     P+  + P  + +  G
Sbjct: 749  -IIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807

Query: 444  ENAVLLVETLEAGVEG------RWSRDGEELPV------ICQSSSGHMHALVLPGVTRED 491
             N      TL   V+G      +W R  + +P+      +   S     AL +  +   D
Sbjct: 808  SNV-----TLPCYVQGYPEPTIKWRR-LDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861

Query: 492  AG----EVTFSLGNSRTTTLLRVKCVKHSPPG-PPILAEMFKGHKNTVLLTWKPPEPAPE 546
             G    E     G  ++ T + V  +     G  P +A + +G + T+  T     P PE
Sbjct: 862  KGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPE 921

Query: 547  TPFIYRLERQEVGSEDWIQ--CFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG-HGRSPH 603
              +I         S   +Q    ++   G++ +    +   G+Y      V+G + ++  
Sbjct: 922  RRWI-------KNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTS 974

Query: 604  VVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQV 663
            VV H    +    ++++ +E + V     A  +   S I    W   GE + ++  +   
Sbjct: 975  VVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI----WSKKGELISTSSAKFSA 1030

Query: 664  EPGALRYRIEQKGLQHRLILHAVKHQDSGALV-------GFSCPGVQDSAALTIQESP-- 714
                  Y +   G            ++SG  V       G++   VQ    LT+   P  
Sbjct: 1031 GADGSLYVVSPGG------------EESGEYVCTATNTAGYAKRKVQ----LTVYVRPRV 1074

Query: 715  ---VHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRK 770
                  LS    V ++    E V L CE+  +  P  TW K+ Q +         +    
Sbjct: 1075 FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGS 1134

Query: 771  HRLILPEAKVQDSGEFECRTEGVSAFFGVTVQ---DPPVHIVDPREHVFVHAITSECVML 827
             +  + E +  DSG + C    ++      V+     P  I    +H+ V     + V +
Sbjct: 1135 MK--ITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQ--VGQRVDI 1190

Query: 828  ACEVDREDAPV-RWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCV----AG 882
             C       PV  W K G  +       + N  P   L +    PSD G + CV    AG
Sbjct: 1191 PCNAQGTPLPVITWSKGGSTMLVDGEHHVSN--PDGTLSIDQATPSDAGIYTCVATNIAG 1248

Query: 883  DECAYFTVTITDVSSW--IVYPSGKVYVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEVV 939
             +    T+ + +  +   +  P    +   V  +R+   C     P   ++W  +G E+ 
Sbjct: 1249 TDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELT 1308

Query: 940  -ESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS----FTVTVTEPPVRIIYPR 994
               P + + ++ T+  LV+ +V   D+GEY+C   +E+ +    + + V  PPV  I  +
Sbjct: 1309 GREPGISILEDGTL--LVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPV--IKDK 1364

Query: 995  DEVTLIAVTL-ECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQ 1052
            ++VT ++V L +   L CE+    +P + WYKD ++V ES  +    +G   +L    A 
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLF--RAT 1422

Query: 1053 PEDGGEFVCD----AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEV-AP 1107
            PED G + C     AG    +F + V  PP  I       + +       V L C+V   
Sbjct: 1423 PEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRD--VALECQVKGT 1480

Query: 1108 AGSQVRWYKDGLEVEASDA-LQLGAEGPTRTLTLPHAQPEDAGEYVCETRH----EAITF 1162
                + W+KDG  +   D  ++L   G  + L L +A+  D G Y C   +    +A   
Sbjct: 1481 PFPDIHWFKDGKPLFLGDPNVELLDRG--QVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538

Query: 1163 NVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLEL 1221
             + +  PP   +      + + V     + L CE      P + W  +G+P+        
Sbjct: 1539 KLTIYIPP--SIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALY 1596

Query: 1222 HAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRS 1281
              +G  + L I  A  + +  YTC      G    SF V V  PP+ +    A     + 
Sbjct: 1597 IDKG--QYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPM-IEGNLATPLNKQV 1653

Query: 1282 TPGGDLELVVHLSGPGGPV-RWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYL 1340
                 L L    +G   P+  W KDG  + +   +++E  G +  L +  A+  D G+Y+
Sbjct: 1654 VIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK--LEIMSAQEIDRGQYI 1711

Query: 1341 CDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF-----------RCEVS-PPDA 1388
            C A        V+ E+ +  + V  L P  +  GD+ ++            C V+  P  
Sbjct: 1712 CVATS------VAGEKEIKYE-VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPP 1764

Query: 1389 DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSAR------L 1442
             + WL++G ++      ++  NG  R L +   Q+ + G     A +TA   +      +
Sbjct: 1765 TIMWLKDGQLIDERDGFKILLNG--RKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822

Query: 1443 HVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPL-PHDSRLSMAQD 1501
            HV  T  +    L +    + + V L+     +    ++ W++  QP+      L +   
Sbjct: 1823 HVPPT--IKSSGLSERVVVKYKPVALQCIANGI-PNPSITWLKDDQPVNTAQGNLKIQSS 1879

Query: 1502 GHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQL 1561
            G +  L I   +L D G Y C +      A  + +  QL V  P    ++ + G    + 
Sbjct: 1880 GRV--LQIAKTLLEDAGRYTCVA---TNAAGETQQHIQLHVHEP---PSLEDAGKMLNET 1931

Query: 1562 ELSQEGVTGEWARGGVQLYPGPKCHIHSDG------------HRHRLV-LNGLGLADSGC 1608
             L    V  E    G    P P    + D             +R +++ +    ++D+G 
Sbjct: 1932 VLVSNPVQLECKAAG---NPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGI 1988

Query: 1609 VSFTADSLRCAARLIVR---EVPVTIVRGPHDLEVTEGDTATFECELSQALA-DVTWEKD 1664
                A +   A  L       V  +I    + + V   +    ECE     A  +TW KD
Sbjct: 1989 YKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVA---V 1721
            G+ ++ S    LQ L   R+L L     SD G Y+C V    AG  +  +  R      +
Sbjct: 2049 GSPVS-SFSNGLQVLSGGRILALTSAQISDTGRYTC-VAVNAAGEKQRDIDLRVYVPPNI 2106

Query: 1722 LSELRSVSAREGDGATFECTVSEV-ETTGRWELGGRPL--RPGARVRIRQEGKKHILVLS 1778
            + E ++VS          C    +   T  W   G PL  +PG  +       + +L + 
Sbjct: 2107 MGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSI----SENRSVLKIE 2162

Query: 1779 ELRAEDAGEVRFQA 1792
            + + +D G    +A
Sbjct: 2163 DAQVQDTGRYTCEA 2176



 Score =  199 bits (506), Expect = 2e-50
 Identities = 309/1266 (24%), Positives = 487/1266 (38%), Gaps = 149/1266 (11%)

Query: 714  PVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHR 772
            P  ++ P+   +LT   +  + LTCE+S    P  +W K+ Q ++ +   ++   GR  +
Sbjct: 2963 PPSVIGPKSE-NLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQ 3021

Query: 773  LILPEAKVQDSGEFEC----RTEGVSAFFGVTVQDPP-VHIVDPREHVFVHAITSECVML 827
            +I   AKV D GE+ C    +       F +TV  PP +   D      V+      V L
Sbjct: 3022 II--RAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSL 3079

Query: 828  ACEVDREDAPV-RWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAG 882
             CE +    PV  WYK+G+ + ES  V +  +G  + L +   + SD G++ C    VAG
Sbjct: 3080 ECESNAVPPPVITWYKNGRMITESTHVEILADG--QMLHIKKAEVSDTGQYVCRAINVAG 3137

Query: 883  DECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR-PWAEVRWTKDGEEVVES 941
             +   F + +  V   I  P  +V V  +    V LTC+    P   + W K+ + +  S
Sbjct: 3138 RDDKNFHLNVY-VPPSIEGPEREVIVETIS-NPVTLTCDATGIPPPTIAWLKNHKRIENS 3195

Query: 942  PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS----FTVTVTEPP--VRIIYPRD 995
             +L ++      +L +   Q  DSG Y C   +        + +++  PP       P D
Sbjct: 3196 DSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD 3255

Query: 996  EVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPE 1054
               L+   +E   L+C  +    P ++W KDG  +   E   +        L +  A   
Sbjct: 3256 VSVLLGENVE---LVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS 3312

Query: 1055 DGGEFVC----DAGDDSAFFTVTVTAPPE-RIVHPAARSLDLHFGAPGRVELRCEVAPAG 1109
            D G++ C     AG++   F + V   P  R     A  L         +E R    P  
Sbjct: 3313 DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP- 3371

Query: 1110 SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT----FNVI 1165
             Q+ W K+GL +  S  ++L A G  + + +  AQ  D   Y C   + A      +N+ 
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAG--QVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429

Query: 1166 LAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAE 1224
            +  PP    ++ T    + V  G    ++C      AP + W  +G+P+     L +   
Sbjct: 3430 VFAPPNMDNSMGT--EEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTH 3487

Query: 1225 GPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPG 1284
            G   VL +  A    +G YTC +    G  S  F ++V EPP    + E  +  V     
Sbjct: 3488 G--MVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISV--IVN 3543

Query: 1285 GDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC-- 1341
              LEL    SG P   + W KDG  L    +VQ    G  +VLR+  A+  D G Y C  
Sbjct: 3544 NPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQT--LGGGEVLRISTAQVEDTGRYTCLA 3601

Query: 1342 --DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAV 1398
               A  D + +LV V  P  +    E   +TV      T  C+    P   +TWLRNG  
Sbjct: 3602 SSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGER 3661

Query: 1399 VTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDV 1458
            +   P+V +   G  R L +    LGD    T  A + A       RE  L         
Sbjct: 3662 LQATPRVRILSGG--RYLQINNADLGDTANYTCVASNIAGKT---TREFILTVNVPPNIK 3716

Query: 1459 RAEEGQDVCLEVETGRVGAAGAV-----RWVRGGQPLP-HDSRLSMAQDGHIHRLFIHGV 1512
               +   + L   T     A  V      W + G  L  + +R S+ ++G +H   I   
Sbjct: 3717 GGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLH---IQSA 3773

Query: 1513 ILADQGTYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
             + D G Y C + +    DR    L V         P  ++T+      T   E +  G+
Sbjct: 3774 HVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPT-NMTVIVNVQTTLACEAT--GI 3830

Query: 1569 TG---EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARL--- 1622
                  W + G  L      ++  + + +RL+ +G  +  S  V  TA +  C       
Sbjct: 3831 PKPSINWRKNGHLL------NVDQNQNSYRLLSSGSLVIISPSVDDTA-TYECTVTNGAG 3883

Query: 1623 -------IVREVPVTIVRGPHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTP-SPR 1673
                   +  +VP +I   P D  VT+   A   C  S      + W K+G  L P    
Sbjct: 3884 DDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDG 3943

Query: 1674 LRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGP---VRLTVRERTVAVLSELRSVSA 1730
             R+ + G   +L  +    + AG Y+C    A       V L V E  V +  +   +  
Sbjct: 3944 YRILSSGAIEILATQL---NHAGRYTCVARNAAGSAHRHVTLHVHEPPV-IQPQPSELHV 3999

Query: 1731 REGDGATFECTVSEVETTGR------WELGGRPLRPGARVRIRQEGKKHILV------LS 1778
               +     C     E TG       W+  G        + +   G+ H ++      +S
Sbjct: 4000 ILNNPILLPC-----EATGTPSPFITWQKEG--------INVNTSGRNHAVLPSGGLQIS 4046

Query: 1779 ELRAEDAGE----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSR 1834
                EDAG      +  AG A     L V+  P+      P  K  ++     + ++   
Sbjct: 4047 RAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVIS----PHLKEYVIAVDKPITLSCEA 4102

Query: 1835 SG---GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQ----AGQDST 1887
             G     + W ++G  +    +  + S G   SL I  V+P D G Y C     AG  ST
Sbjct: 4103 DGLPPPDITWHKDGRAIVESIRQRVLSSG---SLQIAFVQPGDAGHYTCMAANVAGSSST 4159

Query: 1888 HTRLLV 1893
             T+L V
Sbjct: 4160 STKLTV 4165



 Score =  145 bits (366), Expect = 4e-34
 Identities = 217/903 (24%), Positives = 342/903 (37%), Gaps = 135/903 (14%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE-RLSFPADGAEHGL 69
            PP     P+ + ++      L+C+  G P P + W K G  LA +  R S   +G  H  
Sbjct: 3712 PPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLH-- 3769

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
             + +A  TD G Y+C A NAAG       + V  PP+  P                    
Sbjct: 3770 -IQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAP-------------------- 3808

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
               GP +  V+   +  L C A G+P+P++ W K+G  L+   + + + L          
Sbjct: 3809 ---GPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLL--------- 3856

Query: 190  ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLK 249
            +S +L I++  + D+  Y C   N  G  +    L V    + PP+  DE          
Sbjct: 3857 SSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTV----QVPPSIADE---------- 3902

Query: 250  CAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYC 309
              P  F V +   A   C   G P P I W   G  LLP  R   YR    G  +++L  
Sbjct: 3903 --PTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLP--RGDGYRILSSG-AIEILAT 3957

Query: 310  QAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRI 369
            Q    G Y C ARN+AG     V LHV EP +   +P  ++    +   +L C+   +  
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP-SELHVILNNPILLPCEATGTPS 4016

Query: 370  P-TAWFREDQRL-LPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTV-----A 422
            P   W +E   +    R +  +  G ++   I R   +D G Y+C  +    T       
Sbjct: 4017 PFITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKL 4073

Query: 423  NVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDG----EELPVIC 472
            NV V   I   L  K  V+  +  +    TL    +G       W +DG    E +    
Sbjct: 4074 NVQVPPVISPHL--KEYVIAVDKPI----TLSCEADGLPPPDITWHKDGRAIVESIRQRV 4127

Query: 473  QSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKN 532
             SS     A V PG    DAG  T    N   ++    K   H PP        +  ++N
Sbjct: 4128 LSSGSLQIAFVQPG----DAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNEN 4183

Query: 533  TVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRI 592
            +  +     +  P TP I   ++  V   + +  ++ E  G + +    +   G   F  
Sbjct: 4184 SQAILPCVADGIP-TPAI-NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSG---FYT 4238

Query: 593  CTV-SGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI--IQGTWFL 649
            C   +  G   H V   + H++PT   + G  DV +  GE    S   + I   + TW  
Sbjct: 4239 CVANNAAGEDTHTV-SLTVHVLPTFTELPG--DVSLNKGEQLRLSCKATGIPLPKLTWTF 4295

Query: 650  NGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALV---GFSCPGVQDSA 706
            N   + ++               +       L++  V  +DSG  V     S   V+   
Sbjct: 4296 NNNIIPAH--------------FDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIG 4341

Query: 707  ALTIQESPVHILS-PQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVV 764
             + ++E PV     P + +          +L CE+     P   W + G  +E S  +  
Sbjct: 4342 FVYVKEPPVFKGDYPSNWIE---PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQ 4398

Query: 765  KMDGRKHRLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVDPREHVFVHAI 820
              +G    L +     +D+G++ C        V     +T+Q PP+  ++P E V     
Sbjct: 4399 LGNG---SLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVI---N 4452

Query: 821  TSECVMLACEVDREDAP-VRWYKDGQEVEESDFV-VLENEGPHRRLVLPATQPSDGGEFQ 878
                ++L C+   E  P + W + G  +   D V VL N      L +   Q  D  EF+
Sbjct: 4453 AGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS----LYIADAQKEDTSEFE 4508

Query: 879  CVA 881
            CVA
Sbjct: 4509 CVA 4511



 Score =  131 bits (330), Expect = 5e-30
 Identities = 241/1004 (24%), Positives = 391/1004 (38%), Gaps = 116/1004 (11%)

Query: 948  KEDTVRRLVLPAVQLEDSGEYLCEIDDES----ASFTVTVTEPPVRIIYPRDEVTLIAVT 1003
            KE     L +  V L D G Y C     +    A     V+EPP  I  P +    + VT
Sbjct: 477  KESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNN----VTVT 532

Query: 1004 L-ECVVLMCEL-SREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC 1061
              E  VL C + S  D  + W ++  +V  +E   + R      L L + +  D GE+ C
Sbjct: 533  PGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARI-RTLANLSLELKSVKFNDAGEYHC 591

Query: 1062 ----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGS-QVRWYK 1116
                + G  +A   +TV  PP+  V P  +S    F     V + C        ++ W  
Sbjct: 592  MVSSEGGSSAASVFLTVQEPPKVTVMPKNQS----FTGGSEVSIMCSATGYPKPKIAWTV 647

Query: 1117 DGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLAL 1176
            + + +  S   ++ ++G   TL + +A P+DAG Y C   + A T         ++   L
Sbjct: 648  NDMFIVGSHRYRMTSDG---TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKL 704

Query: 1177 ETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAG 1236
                S L VA G+  V+ C+ S    P V    G  ++      L  +    +L IQ   
Sbjct: 705  MVVQSELLVALGDITVMECKTSGIPPPQVKWFKG-DLELRPSTFLIIDPLLGLLKIQETQ 763

Query: 1237 PAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG- 1295
               AG YTC +    G  +   T+ V  PPV +  P      +    G ++ L  ++ G 
Sbjct: 764  DLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEI----GSNVTLPCYVQGY 819

Query: 1296 PGGPVRWYKDG-----ERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIF 1350
            P   ++W +        R  S   +   + GA  +L +    + D G Y+C+A       
Sbjct: 820  PEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLW---ASDKGTYICEAENQ---- 872

Query: 1351 LVSVEEPLLVKLVSELTPL--------TVHEGDDATFRCEV--SPPDADVTWLRNGAVVT 1400
               ++    V +   + PL         V EG   T  C +    P  +  W++N A++ 
Sbjct: 873  FGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLL 932

Query: 1401 PGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTA------TSARLHVRETELLFLRR 1454
              P + +  +GS   L +   QL D G  T  A + A      TS  +HV  T       
Sbjct: 933  QNPYITVRSDGS---LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT---IQHG 986

Query: 1455 LQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDS-RLSMAQDGHIHRLFIHGVI 1513
             Q +   EG  V L  +        +V W + G+ +   S + S   DG ++ +   G  
Sbjct: 987  QQILSTIEGIPVTLPCKASG-NPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-- 1043

Query: 1514 LADQGTYGCESHHDRTLAR------LSVRPRQLRVLRPLE-----DVTISEGGSATFQLE 1562
              + G Y C + +    A+      + VRPR     R L      ++++  G   T   E
Sbjct: 1044 -EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCE 1102

Query: 1563 L-SQEGVTGEWARGGVQLYP-GPKCHIHSDGHRHRLVLNGLGLADSG---CVSFT-ADSL 1616
            + S       WA+    + P  P+   H+      + +     +DSG   CV+   A ++
Sbjct: 1103 VKSLPPPIITWAKETQLISPFSPR---HTFLPSGSMKITETRTSDSGMYLCVATNIAGNV 1159

Query: 1617 RCAARLIVREVPVTIVRGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLR 1675
              A +L V  VP  I RGP  L+V  G      C      L  +TW K G+ +       
Sbjct: 1160 TQAVKLNV-HVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHH 1218

Query: 1676 LQALGTRRLLQLRRCGPSDAGTYSCAVGTARAG----PVRLTVRE-RTVAVLSELRSVSA 1730
            +        L + +  PSDAG Y+C V T  AG     + L V+E  TV  L    + + 
Sbjct: 1219 VS--NPDGTLSIDQATPSDAGIYTC-VATNIAGTDETEITLHVQEPPTVEDLEPPYNTTF 1275

Query: 1731 RE---GDGATFECTVSEV-ETTGRWELGGRPL---RPGARVRIRQEGKKHILVLSELRAE 1783
            +E        F C      + T +W   GR L    PG  + I ++G   +LV++ +   
Sbjct: 1276 QERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPG--ISILEDGT--LLVIASVTPY 1331

Query: 1784 DAGE----VRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGH- 1838
            D GE       +AG  +    L+V   P+   +      +VL+ +   L   V  +    
Sbjct: 1332 DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPI 1391

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
            + W ++  ++      +  ++G    L +    PED G Y C+A
Sbjct: 1392 IMWYKDNVQVTESSTIQTVNNGKI--LKLFRATPEDAGRYSCKA 1433



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 81/327 (24%), Positives = 116/327 (35%), Gaps = 60/327 (18%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P F   P  V +  G +  L C   G P P + W      + A     F +      L++
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH----FDSVNGHSELVI 4315

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
                  D+G YVC A N+ G   A   V V EP                       PVF 
Sbjct: 4316 ERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP-----------------------PVFK 4352

Query: 132  TGPRSQWV-LRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
                S W+   G   +L C   G P PT+ W + G+ +    + SH   Q G        
Sbjct: 4353 GDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDI----EISHRIRQLGNG------ 4402

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
              +L I      D+G Y C A N  G  +    L +  P           P   +EP++ 
Sbjct: 4403 --SLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSP-----------PIITLEPVET 4449

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
                  +N G      C   G+P+P I W  +G  +  D R  +  +      L +   Q
Sbjct: 4450 V-----INAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS----LYIADAQ 4500

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVK 337
             +D   + C ARN  G  L  V + V+
Sbjct: 4501 KEDTSEFECVARNLMGSVLVRVPVIVQ 4527



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 54/204 (26%), Positives = 88/204 (43%), Gaps = 40/204 (19%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
            G  A L C V G+P P + W + G  +  S R+    +G+   L +   +  DAG Y C 
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS---LAIYGTVNEDAGDYTCV 4420

Query: 86   ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145
            A N AG    + ++T+  PP     L+P E  + +                     G ++
Sbjct: 4421 ATNEAGVVERSMSLTLQSPPIIT--LEPVETVINA---------------------GGKI 4457

Query: 146  VLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSG 205
            +L C+A G P+PT+ W + G ++   WD     L          ++ +L I  A+  D+ 
Sbjct: 4458 ILNCQATGEPQPTITWSRQGHSIS--WDDRVNVL----------SNNSLYIADAQKEDTS 4505

Query: 206  VYVCHARNAHGH--AQAGALLQVH 227
             + C ARN  G    +   ++QVH
Sbjct: 4506 EFECVARNLMGSVLVRVPVIVQVH 4529



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 3/92 (3%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            SPP     P    + +G +  L C   GEP P + W + G  ++  +R++  ++   + L
Sbjct: 4438 SPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSN---NSL 4494

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
             +  A   D   + C ARN  G       V V
Sbjct: 4495 YIADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 54/221 (24%), Positives = 86/221 (38%), Gaps = 22/221 (9%)

Query: 1685 LQLRRCGPSDAGTYSC-AVGTARAGPVRLTVR-ERTVAVLSELRSVSAREGDGATFECTV 1742
            L + +   SD G Y C AV +A  G  +          V+    +V+   G+ A   C +
Sbjct: 484  LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLI 543

Query: 1743 -SEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQS 1797
             S V+    W+   R +R     RIR       L L  ++  DAGE    V  + G + +
Sbjct: 544  ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-LELKSVKFNDAGEYHCMVSSEGGSSAA 602

Query: 1798 LALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSG---GHVCWLREGAELCPGDKY 1854
               L V+  P       P+ ++   G    + +  S +G     + W      +    +Y
Sbjct: 603  SVFLTVQEPPKVTVM--PKNQSFTGGSE--VSIMCSATGYPKPKIAWTVNDMFIVGSHRY 658

Query: 1855 EMRSHGPTHSLVIHDVRPEDQGTYCC----QAGQDSTHTRL 1891
             M S G   +L I +  P+D G Y C     AG D  ++ L
Sbjct: 659  RMTSDG---TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696


>gi|110349721 titin isoform novex-3 [Homo sapiens]
          Length = 5604

 Score =  291 bits (745), Expect = 4e-78
 Identities = 315/1294 (24%), Positives = 508/1294 (39%), Gaps = 122/1294 (9%)

Query: 674  QKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAA-LTIQESPVHILSPQDRVSLTFTTSE 732
            +KGLQ    L  + H+  GAL G +    +     + +   PV +L             E
Sbjct: 1810 RKGLQRIEELERMAHE--GALTGVTTDQKEKQKPDIVLYPEPVRVLE-----------GE 1856

Query: 733  RVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTE 791
                 C ++    P   WY +GQ + +S+   V+ DG  H L + + K  D+GE +   E
Sbjct: 1857 TARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGEVKVTAE 1915

Query: 792  GVSAFFGVTVQDPPVHIV-------------DPREHVFVHAITSECVMLACEVDREDAPV 838
                  GV      + I              +PR    VH    E   L  EV + D PV
Sbjct: 1916 NPE---GVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVH----EPGKLQFEVQKVDRPV 1968

Query: 839  -----------------RWYKDGQEVEE--SDFVVLENEGPHRRLV---LPATQPSDG-G 875
                                K  +E EE  S F     EG +  +    L + +  +   
Sbjct: 1969 DTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYE 2028

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL------------- 922
            E      DE  ++T  +T+     +   GK+ +   + +++ L+  +             
Sbjct: 2029 ELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQT 2088

Query: 923  --------------CRPWAEVRWTKDGEEVVESPALLLQ-KEDTVRRLVLPAVQLEDSGE 967
                           +P  E  W K+G ++  S  +     ED V  LV+  V  EDS  
Sbjct: 2089 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSAS 2148

Query: 968  YLCE---IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM-CELSREDAPVRWY 1023
             + +   I  E++S    + +    I + ++   ++A   + +    CE S     V+WY
Sbjct: 2149 IMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWY 2208

Query: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVH 1083
            KDG+EV E +   +  D     L +      D  ++ C   +D    T         +V 
Sbjct: 2209 KDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVE 2268

Query: 1084 PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHA 1143
                  D+        EL C V+P   + +WY + +E++++    + +    + LT+   
Sbjct: 2269 FVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDV 2328

Query: 1144 QPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP 1203
              ED GEY      +  T  + +   P+  L      S   V  G+ V L  ++S     
Sbjct: 2329 TKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQ---GLSDQKVCEGDIVQLEVKVSLESVE 2385

Query: 1204 VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVA 1263
             VW  +G+ VQ  + + +  +    +L I+      AG Y+    A      LS + +V+
Sbjct: 2386 GVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPAL----GLSTSGRVS 2441

Query: 1264 EPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG-GPVRWYKDGERLASQGRVQLEQAGA 1322
               V V+ P      V    G    L   +S P    V+WY + E++    RVQ    G 
Sbjct: 2442 VYSVDVITP---LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT 2498

Query: 1323 RQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCE 1382
            +Q L +    + D G Y     +      +SVE+   +K++  L  LT  E  +  F  E
Sbjct: 2499 KQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK---IKIIRGLRDLTCTETQNVVFEVE 2555

Query: 1383 VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARL 1442
            +S    DV W      + P  + ++  +G    LT+      D G  T  AG   TS +L
Sbjct: 2556 LSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKL 2615

Query: 1443 HVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG 1502
             V    +   + L D    E Q+   E E     + G   W+R G+ LP  + +    DG
Sbjct: 2616 TVAGGAIS--KPLTDQTVAESQEAVFECEVANPDSKG--EWLRDGKHLPLTNNIRSESDG 2671

Query: 1503 HIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE 1562
            H  RL I    L D G Y  +    +T A+L V    +++ + L+++T++E   A F +E
Sbjct: 2672 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEA--VKIKKTLKNLTVTETQDAVFTVE 2729

Query: 1563 LSQEGVTG-EWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAAR 1621
            L+   V G +W + GV L    K  I   G  + L +    + D     F    L  +AR
Sbjct: 2730 LTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASAR 2789

Query: 1622 LIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGT 1681
            L V  V   I++ P D+   E  T  FE  +S     V W      + PS + RL +   
Sbjct: 2790 LHVETVK--IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERK 2847

Query: 1682 RRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECT 1741
               L L+   PSDAG Y+  VG       +  +   T+ +   ++++   E   A+FEC 
Sbjct: 2848 VHKLMLQNISPSDAGEYTAVVGQLEC---KAKLFVETLHITKTMKNIEVPETKTASFECE 2904

Query: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALL 1801
            VS       W   G  +    + +I  +GK H L++     ED+ E  F  G  Q  A L
Sbjct: 2905 VSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATL 2964

Query: 1802 EVEALPL-QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHG 1860
             V  + +  M +    E+   +      EVTV+  G    WL+ G E+   DK +MR+  
Sbjct: 2965 TVTPIMITSMLKDINAEEKDTI----TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKK 3020

Query: 1861 PTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
             THSL I +V   D   Y   AG+ ++   L VE
Sbjct: 3021 LTHSLNIRNVHFGDAADYTFVAGKATSTATLYVE 3054



 Score =  283 bits (723), Expect = 1e-75
 Identities = 253/1072 (23%), Positives = 449/1072 (41%), Gaps = 36/1072 (3%)

Query: 831  VDREDAPVRWYKDGQEVEESDFVVLE-NEGPHRRLVLPATQPSDGGEFQC----VAGDEC 885
            V + D    WYK+G ++E SD +     E     LV+      D          +AG+  
Sbjct: 2102 VGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETS 2161

Query: 886  AYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945
            ++  + +            +  VA  +       CE   P+ +V+W KDG EV E     
Sbjct: 2162 SHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYR 2221

Query: 946  LQKEDTVRRLVLPAVQLEDSGEYLCE-IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTL 1004
            +  +  V  L +  +   D+ +Y C  ++DE+   T  +      + + ++   +     
Sbjct: 2222 MHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPES 2281

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
                L C +S E+   +WY + +E++ +    +     R  L +     ED GE+     
Sbjct: 2282 YSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVID 2341

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
                   + +   P  I+   +   D        V+L  +V+    +  W KDG EV+ S
Sbjct: 2342 GKKTTCKLKMKPRPIAILQGLS---DQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPS 2398

Query: 1125 DALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            D + +  +  +  L +     EDAG Y        ++ +  ++   V  +   T    + 
Sbjct: 2399 DRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVI---TPLKDVN 2455

Query: 1185 VAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLY 1243
            V  G   VL C++S      V W  N   ++  + ++   +G ++ L I     +  G Y
Sbjct: 2456 VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2515

Query: 1244 TCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWY 1303
                G      +LS         V  +        +  T   ++   V LS  G  V W 
Sbjct: 2516 KLIVGRVETNCNLS---------VEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2566

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLV 1363
               + +    + ++E  G    L V      D G+Y   A ++     ++V    + K  
Sbjct: 2567 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISK-- 2624

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQL 1423
              LT  TV E  +A F CEV+ PD+   WLR+G  +     +    +G  R L +   +L
Sbjct: 2625 -PLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKL 2683

Query: 1424 GDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRW 1483
             D G  T +  ++ TSA+L V   ++   + L+++   E QD    VE       G V+W
Sbjct: 2684 DDIGEYTYKVATSKTSAKLKVEAVKIK--KTLKNLTVTETQDAVFTVELTHPNVKG-VQW 2740

Query: 1484 VRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVL 1543
            ++ G  L  + + +++  G I+ L I    + D+  YG         ARL V    ++++
Sbjct: 2741 IKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET--VKII 2798

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            +  +DVT  E  +  F++ +S + V  +W    V++ P  K  + S+   H+L+L  +  
Sbjct: 2799 KKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISP 2858

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
            +D+G  +     L C A+L V  + +T  +   ++EV E  TA+FECE+S       W K
Sbjct: 2859 SDAGEYTAVVGQLECKAKLFVETLHIT--KTMKNIEVPETKTASFECEVSHFNVPSMWLK 2916

Query: 1664 DGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLS 1723
            +G  +  S + ++   G    L +      D+  Y+   G  +   V  T+    + + S
Sbjct: 2917 NGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQ---VSATLTVTPIMITS 2973

Query: 1724 ELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
             L+ ++A E D  TFE TV+    + +W   G  ++   + ++R +   H L +  +   
Sbjct: 2974 MLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFG 3033

Query: 1784 DAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLR 1843
            DA +  F AG A S A L VEA  ++  +H  ++  VL  +RA+ E  VS     V W++
Sbjct: 3034 DAADYTFVAGKATSTATLYVEARHIEFRKHI-KDIKVLEKKRAMFECEVSEPDITVQWMK 3092

Query: 1844 EGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEG 1895
            +  EL   D+ +++     H L+I   R  D G Y   AG + +  +L VEG
Sbjct: 3093 DDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEG 3144



 Score =  259 bits (661), Expect = 2e-68
 Identities = 275/1223 (22%), Positives = 496/1223 (40%), Gaps = 93/1223 (7%)

Query: 619  VAGLEDVQV---YDGE-DAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQ 674
            V  L+D++V   Y GE + + S +    I+G W+ N  ELKSN           +Y I  
Sbjct: 2270 VKELQDIEVPESYSGELECIVSPEN---IEGKWYHNDVELKSNG----------KYTITS 2316

Query: 675  KGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERV 734
            +  +  L +  V  +D G    F   G + +  L ++  P+ IL  Q          + V
Sbjct: 2317 RRGRQNLTVKDVTKEDQGEY-SFVIDGKKTTCKLKMKPRPIAIL--QGLSDQKVCEGDIV 2373

Query: 735  VLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVS 794
             L  ++S       W KDGQ+V+ S+ + + +D + H L++ +   +D+G +      + 
Sbjct: 2374 QLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALG 2433

Query: 795  AFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFV 853
                  V    V ++ P + V V  I     +L C+V   D   V+WY + ++++  D V
Sbjct: 2434 LSTSGRVSVYSVDVITPLKDVNV--IEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRV 2491

Query: 854  VLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRL 913
                +G  +RLV+  T  SD G ++ + G       +++  +        G   +     
Sbjct: 2492 QAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIK----IIRGLRDLTCTET 2547

Query: 914  ERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEID 973
            + VV   EL     +V W    +E+  S    ++    + +L +  +  +D G+Y     
Sbjct: 2548 QNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAG 2607

Query: 974  DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESE 1033
            +   S  +TV    +    P  + T +A + E V   CE++  D+   W +DG  +  + 
Sbjct: 2608 ENMTSGKLTVAGGAIS--KPLTDQT-VAESQEAV-FECEVANPDSKGEWLRDGKHLPLTN 2663

Query: 1034 ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHF 1093
             +  E DG + RL++ A + +D GE+            + V A     +    ++L +  
Sbjct: 2664 NIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVK---IKKTLKNLTVTE 2720

Query: 1094 --GAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY 1151
               A   VEL     P    V+W K+G+ +E+++   +  +G   +L + +    D   Y
Sbjct: 2721 TQDAVFTVEL---THPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 2777

Query: 1152 VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGR 1211
                     +     A   V+ + +   P  +       V     +S    PV W H   
Sbjct: 2778 GFRLGRLGAS-----ARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSV 2832

Query: 1212 PVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSF-TVQVAEPPVRVV 1270
             ++  +   L +E     L +Q   P+ AG YT   G       L   T+ + +    + 
Sbjct: 2833 EIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIE 2892

Query: 1271 APEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
             PE        T   + E V H + P     W K+G  +    + ++   G    L +  
Sbjct: 2893 VPET------KTASFECE-VSHFNVPS---MWLKNGVEIEMSEKFKIVVQGKLHQLIIMN 2942

Query: 1331 ARSGDAGEY--LCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDA 1388
              + D+ EY  +C   Q S    V+   P+++   S L  +   E D  TF   V+    
Sbjct: 2943 TSTEDSAEYTFVCGNDQVSATLTVT---PIMI--TSMLKDINAEEKDTITFEVTVNYEGI 2997

Query: 1389 DVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETE 1448
               WL+NG  +    + +M     +  L +R    GDA   T  AG   ++A L+V    
Sbjct: 2998 SYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARH 3057

Query: 1449 LLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLF 1508
            + F + ++D++  E +    E E         V+W++  Q L    R+ + ++ ++HRL 
Sbjct: 3058 IEFRKHIKDIKVLEKKRAMFECEVSEPDIT--VQWMKDDQELQITDRIKIQKEKYVHRLL 3115

Query: 1509 IHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
            I    ++D G Y   +  + + A+L V  R +R+    ++V + E   A  + E++++ V
Sbjct: 3116 IPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDV 3175

Query: 1569 TGEWARGGVQL-YPGPKCHIHSDGHR-HRLVLNGLGLADSGCVSFTADSLRCAARLIVRE 1626
               W + G+++ +   + H +    R HR+ ++    +D+G  +F A   R +  L V  
Sbjct: 3176 DAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNA 3235

Query: 1627 V-PVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRL 1684
              P  +++    + V  G  A F   +S +    ++W K+   L+   + +    G    
Sbjct: 3236 PEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYT 3295

Query: 1685 LQLRRCGPSDAGTYSC------AVGTARAGPVRLTVRERTV------------AVLSELR 1726
            L L    P DA  Y+C       V T  A    L+V    V            A+++ L+
Sbjct: 3296 LLLIEAFPEDAAVYTCEAKNDYGVATTSAS---LSVEVPEVVSPDQEMPVYPPAIITPLQ 3352

Query: 1727 SVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG 1786
                 EG  A F+C VS  +    W    + ++P    R+ Q    + L ++E   ED G
Sbjct: 3353 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3412

Query: 1787 EVRFQA----GPAQSLALLEVEA 1805
               F A    G   S A L +EA
Sbjct: 3413 TYTFVASNAVGQVSSTANLSLEA 3435



 Score =  257 bits (657), Expect = 7e-68
 Identities = 273/1217 (22%), Positives = 467/1217 (38%), Gaps = 48/1217 (3%)

Query: 681  LILHAVKHQDSGALV--GFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVV-LT 737
            L++  V  +DS +++    +  G   S A  + ++   I   Q+   +     + +    
Sbjct: 2136 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFE 2195

Query: 738  CELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC---RTEGVS 794
            CE S       WYKDG +V E +   +  D + H L +      D+ ++ C     E V 
Sbjct: 2196 CETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVK 2255

Query: 795  AFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVV 854
                + V+   V  V   + + V    S    L C V  E+   +WY +  E++ +    
Sbjct: 2256 TTAKLIVEGAVVEFVKELQDIEVPESYSG--ELECIVSPENIEGKWYHNDVELKSNGKYT 2313

Query: 855  LENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLE 914
            + +    + L +      D GE+  V   +    T  +      I    G         +
Sbjct: 2314 ITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKT--TCKLKMKPRPIAILQGLSDQKVCEGD 2371

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V L  ++     E  W KDG+EV  S  + +  +     L++  +  ED+G Y   I  
Sbjct: 2372 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPA 2431

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESE 1033
               S +  V+   V +I P  +V +I  T    VL C++S  D   V+WY +  +++  +
Sbjct: 2432 LGLSTSGRVSVYSVDVITPLKDVNVIEGTK--AVLECKVSVPDVTSVKWYLNDEQIKPDD 2489

Query: 1034 ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSL-DLH 1092
             +     G + RLV+      D G +    G       ++V    E+I     R L DL 
Sbjct: 2490 RVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSV----EKI--KIIRGLRDLT 2543

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                  V    E++ +G  V W     E++ S   ++ A G    LT+ +   +D G+Y 
Sbjct: 2544 CTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYT 2603

Query: 1153 CETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRP 1212
                    +  + +A   +     + T     VA  +  V  CE++   +   W  +G+ 
Sbjct: 2604 FYAGENMTSGKLTVAGGAISKPLTDQT-----VAESQEAVFECEVANPDSKGEWLRDGKH 2658

Query: 1213 VQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
            +     +   ++G +R L I A      G YT +   +  +  L          V  V  
Sbjct: 2659 LPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLK---------VEAVKI 2709

Query: 1273 EAAQTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGA 1331
            +     +  T   D    V L+ P    V+W K+G  L S  +  +   G    LR++  
Sbjct: 2710 KKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNC 2769

Query: 1332 RSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVT 1391
               D   Y     +      + VE   ++K   ++T L   E     F   VS     V 
Sbjct: 2770 AIVDESVYGFRLGRLGASARLHVETVKIIKKPKDVTAL---ENATVAFEVSVSHDTVPVK 2826

Query: 1392 WLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLF 1451
            W      + P  +  +        L L+     DAG  T   G     A+L V    +  
Sbjct: 2827 WFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHIT- 2885

Query: 1452 LRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHG 1511
             + ++++   E +    E E           W++ G  +    +  +   G +H+L I  
Sbjct: 2886 -KTMKNIEVPETKTASFECEVSHFNVPSM--WLKNGVEIEMSEKFKIVVQGKLHQLIIMN 2942

Query: 1512 VILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE 1571
                D   Y     +D+  A L+V P  + +   L+D+   E  + TF++ ++ EG++ +
Sbjct: 2943 TSTEDSAEYTFVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITFEVTVNYEGISYK 3000

Query: 1572 WARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTI 1631
            W + GV++    KC + +    H L +  +   D+   +F A      A L V    +  
Sbjct: 3001 WLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEF 3060

Query: 1632 VRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCG 1691
             +   D++V E   A FECE+S+    V W KD   L  + R+++Q       L +    
Sbjct: 3061 RKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTR 3120

Query: 1692 PSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRW 1751
             SDAG Y+   G       +L V  R V + S  + V   E   A  E  V+E +    W
Sbjct: 3121 MSDAGKYTVVAG-GNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHW 3179

Query: 1752 ELGGRPLRPGARVRIRQ--EGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQ 1809
               G  +    + R +   E + H + +SE R  DAGE  F AG  +S   L V A    
Sbjct: 3180 YKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPP 3239

Query: 1810 MCRHPPREKTVLVGRRAVLEVTVS-RSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIH 1868
                  +  TV  G+ A     +S R    + W +E   L  G K +    G  ++L++ 
Sbjct: 3240 QVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLI 3299

Query: 1869 DVRPEDQGTYCCQAGQD 1885
            +  PED   Y C+A  D
Sbjct: 3300 EAFPEDAAVYTCEAKND 3316



 Score =  256 bits (655), Expect = 1e-67
 Identities = 367/1657 (22%), Positives = 644/1657 (38%), Gaps = 207/1657 (12%)

Query: 233  PPADPDEAPAPVVEPLKCAPKTF------WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            P   PD+     + P   APK F       V +G  A FR  V+GKP+PE EW+  G  +
Sbjct: 2062 PTFKPDKIE---LSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI 2118

Query: 287  LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRL-RFTR 345
                R   Y   D    L +    A+D    +  A N AG+T S   L V+  +L  FT+
Sbjct: 2119 ERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2178

Query: 346  PLQDVEGREHG-IAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKA 404
             LQDV  +E   +A  EC+     +   W+++   +    KY    +  V  L I  +  
Sbjct: 2179 ELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDT 2238

Query: 405  DDDGIYLCEM--RGRVRTVANVTVKGPILKRLP--RKLDVLEGENAVLLVETLEAGVEGR 460
             D   Y C +     V+T A + V+G +++ +   + ++V E  +  L        +EG+
Sbjct: 2239 SDAEDYSCVLVEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGK 2298

Query: 461  WSRDGEEL----PVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHS 516
            W  +  EL         S  G  + L +  VT+ED GE +F +   +TT  L++K     
Sbjct: 2299 WYHNDVELKSNGKYTITSRRGRQN-LTVKDVTKEDQGEYSFVIDGKKTTCKLKMK----- 2352

Query: 517  PPGPPILAEMFKGHK----NTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKA 572
             P P  + +     K    + V L  K    + E   ++  + QEV   D +     +++
Sbjct: 2353 -PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEG--VWMKDGQEVQPSDRVHIVIDKQS 2409

Query: 573  GAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGED 632
              + +        G+Y F I  + G   S  V  +    + P       L+DV V +G  
Sbjct: 2410 HMLLIEDMTKEDAGNYSFTIPAL-GLSTSGRVSVYSVDVITP-------LKDVNVIEGTK 2461

Query: 633  AVFSLDLST--IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQD 690
            AV    +S   +    W+LN E++K ++          R +   KG + RL+++     D
Sbjct: 2462 AVLECKVSVPDVTSVKWYLNDEQIKPDD----------RVQAIVKGTKQRLVINRTHASD 2511

Query: 691  SG---ALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA 747
             G    +VG     V+ +  L++++  + I   +D   LT T ++ VV   ELS      
Sbjct: 2512 EGPYKLIVG----RVETNCNLSVEKIKI-IRGLRD---LTCTETQNVVFEVELSHSGIDV 2563

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEF-----ECRTEGVSAFFGVTVQ 802
             W    ++++ S    ++  G+ ++L +      D G++     E  T G     G  + 
Sbjct: 2564 LWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAIS 2623

Query: 803  DPPVH--IVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGP 860
             P     + + +E VF            CEV   D+   W +DG+ +  ++ +  E++G 
Sbjct: 2624 KPLTDQTVAESQEAVF-----------ECEVANPDSKGEWLRDGKHLPLTNNIRSESDGH 2672

Query: 861  HRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKV-----YVAAVRLER 915
             RRL++ AT+  D GE+          + V  +  S+ +   + K+      +     + 
Sbjct: 2673 KRRLIIAATKLDDIGEYT---------YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2723

Query: 916  VVLTCELCRPWAE-VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
             V T EL  P  + V+W K+G  +  +    +  + T+  L +    + D   Y   +  
Sbjct: 2724 AVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGR 2783

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEA 1034
              AS  + V    V+II    +VT  A+    V     +S +  PV+W+   +E++ S+ 
Sbjct: 2784 LGASARLHV--ETVKIIKKPKDVT--ALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDK 2839

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDAGD---DSAFF--TVTVTAPPERIVHPAARSL 1089
              L  +    +L+L    P D GE+    G     +  F  T+ +T   + I  P  ++ 
Sbjct: 2840 HRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT- 2898

Query: 1090 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
                         CEV+       W K+G+E+E S+  ++  +G    L + +   ED+ 
Sbjct: 2899 ---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSA 2949

Query: 1150 EY--VCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWS 1207
            EY  VC     + T  V     P+   ++      +     + +     ++  G    W 
Sbjct: 2950 EYTFVCGNDQVSATLTV----TPIMITSM---LKDINAEEKDTITFEVTVNYEGISYKWL 3002

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE--- 1264
             NG  ++  +  ++  +     L I+      A  YT  +G A    +L    +  E   
Sbjct: 3003 KNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRK 3062

Query: 1265 --PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGA 1322
                ++V+  + A                 +S P   V+W KD + L    R+++++   
Sbjct: 3063 HIKDIKVLEKKRAM------------FECEVSEPDITVQWMKDDQELQITDRIKIQKEKY 3110

Query: 1323 RQVLRVQGARSGDAGEYLCDA---PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
               L +   R  DAG+Y   A      +++F+    E   V++ S    + V E   A  
Sbjct: 3111 VHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFV----EGRDVRIRSIKKEVQVIEKQRAVV 3166

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRI--LTLRGCQLGDAGTVTLRAGSTA 1437
              EV+  D D  W ++G  +    Q         RI  + +   +  DAG  T  AG   
Sbjct: 3167 EFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNR 3226

Query: 1438 TSARLHVRETE-LLFLRRLQDVRAEEGQDV-CLEVETGRVGAAGAVRWVRGGQPLPHDSR 1495
            +S  L+V   E    L+ LQ V  + G+      V +GR      + W +  Q L    +
Sbjct: 3227 SSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGR--PQPKISWYKEEQLLSTGFK 3284

Query: 1496 LSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RTLARLSVRPRQL----------- 1540
                 DG  + L +      D   Y CE+ +D     T A LSV   ++           
Sbjct: 3285 CKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP 3344

Query: 1541 -RVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLN 1599
              ++ PL+D   SEG  A FQ  +S   +   W     ++ P     +      ++L + 
Sbjct: 3345 PAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIA 3404

Query: 1600 GLGLADSGCVSFTADS----LRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQA 1655
                 D G  +F A +    +   A L + E P +I+    + E+       F    S+ 
Sbjct: 3405 EAYPEDEGTYTFVASNAVGQVSSTANLSL-EAPESILHERIEQEIEMEMKELF----SEG 3459

Query: 1656 LADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVR 1715
             ++ +     +A + S  +  +++  +R              Y+  + +  + P      
Sbjct: 3460 ESEHSERDTRDAFSDSEDIDHKSMAAKR--------------YASRISSTSSWPEYF--- 3502

Query: 1716 ERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKH- 1773
                +   +L      EG+   F C +    T    W    RP+  G R  I+ E   H 
Sbjct: 3503 --KPSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHH 3560

Query: 1774 ---ILVLSELRAEDAGEVRFQA----GPAQSLALLEV 1803
                L +  ++  D+G  R  A    G A+S A L V
Sbjct: 3561 HSSSLEIKRVQDRDSGSYRLLAINSEGSAESTASLLV 3597



 Score =  254 bits (650), Expect = 4e-67
 Identities = 296/1330 (22%), Positives = 527/1330 (39%), Gaps = 109/1330 (8%)

Query: 612  LVPTARLVAGLEDVQ--VYDGEDAVFSLDLST---IIQGTWFLNGEELKSNEPEGQVEPG 666
            LV   +L+   +++Q  V   +D + + +  T    ++  W+ +G E+   +        
Sbjct: 2167 LVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGD-------- 2218

Query: 667  ALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD-----SAALTIQESPVHILSPQ 721
              +YR+      H L +  +   D+     +SC  V+D     +A L ++ + V  +   
Sbjct: 2219 --KYRMHSDRKVHFLSILTIDTSDAE---DYSCVLVEDENVKTTAKLIVEGAVVEFVKEL 2273

Query: 722  DRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ 781
              + +  + S    L C +S  +    WY +  +++ +    +     +  L + +   +
Sbjct: 2274 QDIEVPESYSGE--LECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKE 2331

Query: 782  DSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWY 841
            D GE+    +G      + ++  P+ I+       V     + V L  +V  E     W 
Sbjct: 2332 DQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKV--CEGDIVQLEVKVSLESVEGVWM 2389

Query: 842  KDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            KDGQEV+ SD V +  +     L++      D G +          FT+    +S+    
Sbjct: 2390 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYS---------FTIPALGLST---- 2436

Query: 902  PSGKVYVAAVRL------------ERVVLTCELCRP-WAEVRWTKDGEEVVESPALLLQK 948
             SG+V V +V +             + VL C++  P    V+W  + E++     +    
Sbjct: 2437 -SGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV 2495

Query: 949  EDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV 1008
            + T +RLV+      D G Y   +     +  ++V +  ++II    ++T      + VV
Sbjct: 2496 KGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK--IKIIRGLRDLT--CTETQNVV 2551

Query: 1009 LMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA 1068
               ELS     V W     E++ S    +E  G   +L +     +D G++   AG++  
Sbjct: 2552 FEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMT 2611

Query: 1069 FFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQ 1128
               +TV      I  P     D            CEVA   S+  W +DG  +  ++ ++
Sbjct: 2612 SGKLTVAGGA--ISKPLT---DQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIR 2666

Query: 1129 LGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPG 1188
              ++G  R L +   + +D GEY  +     +  +   A+  V+ + ++ T   L V   
Sbjct: 2667 SESDGHKRRLIIAATKLDDIGEYTYK-----VATSKTSAKLKVEAVKIKKTLKNLTVTET 2721

Query: 1189 EPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
            +  V + EL+      V W  NG  ++  E   +  +G    L I+        +Y  + 
Sbjct: 2722 QDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRL 2781

Query: 1248 GAAPGAPSLSF-TVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
            G    +  L   TV++ + P  V A E A               V +S    PV+W+   
Sbjct: 2782 GRLGASARLHVETVKIIKKPKDVTALENATVAFE----------VSVSHDTVPVKWFHKS 2831

Query: 1307 ERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSEL 1366
              +    + +L        L +Q     DAGEY     Q      + VE   + K +  +
Sbjct: 2832 VEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNI 2891

Query: 1367 TPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDA 1426
                V E   A+F CEVS  +    WL+NG  +    + ++   G    L +      D+
Sbjct: 2892 E---VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDS 2948

Query: 1427 GTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRG 1486
               T   G+   SA L V  T ++    L+D+ AEE   +  EV     G +   +W++ 
Sbjct: 2949 AEYTFVCGNDQVSATLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGIS--YKWLKN 3004

Query: 1487 GQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPL 1546
            G  +    +  M      H L I  V   D   Y   +    + A L V  R +   + +
Sbjct: 3005 GVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHI 3064

Query: 1547 EDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADS 1606
            +D+ + E   A F+ E+S+  +T +W +   +L    +  I  + + HRL++    ++D+
Sbjct: 3065 KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3124

Query: 1607 GCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGN 1666
            G  +  A      A+L V    V I     +++V E   A  E E+++   D  W KDG 
Sbjct: 3125 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3184

Query: 1667 ALTPSPRLRLQALGTRRL--LQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSE 1724
             +    + R + +  RR+  + +     SDAG Y+   G  R+             VL E
Sbjct: 3185 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQE 3244

Query: 1725 LRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
            L+ V+ + G  A F   +S   +    W    + L  G + +   +G+++ L+L E   E
Sbjct: 3245 LQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3304

Query: 1784 DAG----EVRFQAGPAQSLALLEVEALPL-----QMCRHPPREKTVLV------GRRAVL 1828
            DA     E +   G A + A L VE   +     +M  +PP   T L       G+ A  
Sbjct: 3305 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3364

Query: 1829 EVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQ 1884
            +  VS +   V W  +  ++ P   + M     T+ L I +  PED+GTY   A    GQ
Sbjct: 3365 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3424

Query: 1885 DSTHTRLLVE 1894
             S+   L +E
Sbjct: 3425 VSSTANLSLE 3434



 Score =  202 bits (514), Expect = 3e-51
 Identities = 155/558 (27%), Positives = 257/558 (46%), Gaps = 27/558 (4%)

Query: 1353 SVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNG 1411
            S+E P   K+   +   TV +G DA FR  V   PD +  W +NG  +    ++      
Sbjct: 2074 SMEAP---KIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPE 2130

Query: 1412 SSRI-LTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELL-FLRRLQDVRAEEGQD 1465
             +   L +R     D+ ++ ++A    G T++ A L V+  +L+ F + LQDV A+E   
Sbjct: 2131 DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDT 2190

Query: 1466 VC-LEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC-- 1522
            +   E ET        V+W + G  +    +  M  D  +H L I  +  +D   Y C  
Sbjct: 2191 MATFECETSEPFVK--VKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVL 2248

Query: 1523 -ESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYP 1581
             E  + +T A+L V    +  ++ L+D+ + E  S   +  +S E + G+W    V+L  
Sbjct: 2249 VEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKS 2308

Query: 1582 GPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVT 1641
              K  I S   R  L +  +   D G  SF  D  +   +L ++  P+ I++G  D +V 
Sbjct: 2309 NGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVC 2368

Query: 1642 EGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC- 1700
            EGD    E ++S    +  W KDG  + PS R+ +       +L +      DAG YS  
Sbjct: 2369 EGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFT 2428

Query: 1701 --AVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRP 1757
              A+G + +G V +     +V V++ L+ V+  EG  A  EC VS  + T  +W L    
Sbjct: 2429 IPALGLSTSGRVSV----YSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQ 2484

Query: 1758 LRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPRE 1817
            ++P  RV+   +G K  LV++   A D G  +   G  ++   L VE + +       R+
Sbjct: 2485 IKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKIKI---IRGLRD 2541

Query: 1818 KTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGT 1877
             T    +  V EV +S SG  V W  +  E+ P  KY++ +HG  + L + ++  +D+G 
Sbjct: 2542 LTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGK 2601

Query: 1878 YCCQAGQDSTHTRLLVEG 1895
            Y   AG++ T  +L V G
Sbjct: 2602 YTFYAGENMTSGKLTVAG 2619



 Score =  189 bits (480), Expect = 2e-47
 Identities = 327/1504 (21%), Positives = 555/1504 (36%), Gaps = 185/1504 (12%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERL--SFPADGAEHGLLLTAALPTDAG 80
            V  G++A  +  V+G+P P   W K G ++  S+R+   +P D     L++      D+ 
Sbjct: 2089 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCE-LVIRDVTAEDSA 2147

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
              + +A N AGE  + A + V                           +  T      V 
Sbjct: 2148 SIMVKAINIAGETSSHAFLLVQAKQL----------------------ITFTQELQDVVA 2185

Query: 141  RGAEVVLT--CRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
            +  + + T  C     P   + W KDGM   EV +   + +   R          L IL 
Sbjct: 2186 KEKDTMATFECETSE-PFVKVKWYKDGM---EVHEGDKYRMHSDRKVH------FLSILT 2235

Query: 199  ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVN 258
                D+  Y C             L++      +     + A    V+ L    +   V 
Sbjct: 2236 IDTSDAEDYSC------------VLVEDENVKTTAKLIVEGAVVEFVKEL----QDIEVP 2279

Query: 259  EGKHAKFRCYVMGKPEPEIEWHWEGRPL-LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLY 317
            E    +  C V   PE  IE  W    + L    +     R G   L V     +D+G Y
Sbjct: 2280 ESYSGELECIV--SPE-NIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEY 2336

Query: 318  VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
                        +  +L +K   +   + L D +  E  I  LE KV    +   W ++ 
Sbjct: 2337 SFVIDGKK----TTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDG 2392

Query: 378  QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL-------CEMRGRVRTVANVTVKGPI 430
            Q + P  +   + +     L+I  +  +D G Y            GRV +V +V V  P+
Sbjct: 2393 QEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRV-SVYSVDVITPL 2451

Query: 431  LKRLPRKLDVLEGENAVLLVETLEAGVEG-RWSRDGEELPV---ICQSSSGHMHALVLPG 486
                 + ++V+EG  AVL  +     V   +W  + E++     +     G    LV+  
Sbjct: 2452 -----KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 2506

Query: 487  VTREDAGEVTFSLGNSRTTTLLRVKCVK--------HSPPGPPILAEMFKGHKN-TVLLT 537
                D G     +G   T   L V+ +K               ++ E+   H    VL  
Sbjct: 2507 THASDEGPYKLIVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2566

Query: 538  WKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSG 597
            +K  E  P +   Y++E              I K   + +  D    EG Y F       
Sbjct: 2567 FKDKEIKPSSK--YKIEAHG----------KIYKLTVLNMMKD---DEGKYTF---YAGE 2608

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLST-IIQGTWFLNGEELKS 656
            +  S  +   G A   P       L D  V + ++AVF  +++    +G W  +G+ L  
Sbjct: 2609 NMTSGKLTVAGGAISKP-------LTDQTVAESQEAVFECEVANPDSKGEWLRDGKHL-- 2659

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVH 716
                    P     R E  G + RLI+ A K  D G    +     + SA L ++   + 
Sbjct: 2660 --------PLTNNIRSESDGHKRRLIIAATKLDDIGEYT-YKVATSKTSAKLKVEAVKI- 2709

Query: 717  ILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLIL 775
                +   +LT T ++  V T EL+  +     W K+G  +E +E   + + G  + L +
Sbjct: 2710 ---KKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI 2766

Query: 776  PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDRED 835
                + D   +  R   + A   + V+   + I  P++   V A+ +  V     V  + 
Sbjct: 2767 KNCAIVDESVYGFRLGRLGASARLHVETVKI-IKKPKD---VTALENATVAFEVSVSHDT 2822

Query: 836  APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-ECA----YFTV 890
             PV+W+    E++ SD   L +E    +L+L    PSD GE+  V G  EC       T+
Sbjct: 2823 VPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL 2882

Query: 891  TITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKED 950
             IT     I  P  K              CE+        W K+G E+  S    +  + 
Sbjct: 2883 HITKTMKNIEVPETKT---------ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQG 2933

Query: 951  TVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLM 1010
             + +L++     EDS EY     ++  S T+TVT  P+ I     ++   A   + +   
Sbjct: 2934 KLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVT--PIMITSMLKDIN--AEEKDTITFE 2989

Query: 1011 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 1070
              ++ E    +W K+G+E++ ++   +        L +      D  ++   AG  ++  
Sbjct: 2990 VTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTA 3049

Query: 1071 TVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
            T+ V A   R +       D+      R    CEV+     V+W KD  E++ +D +++ 
Sbjct: 3050 TLYVEA---RHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQ 3106

Query: 1131 AEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEP 1190
             E     L +P  +  DAG+Y         T  + +    V+  +++     + V   + 
Sbjct: 3107 KEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIK---KEVQVIEKQR 3163

Query: 1191 VVLSCELSRAGAPVVWSHNGRPV--QEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSG 1248
             V+  E++       W  +G  +  Q  E  +   E     + I     + AG YT  +G
Sbjct: 3164 AVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAG 3223

Query: 1249 AAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGE 1307
                  S++  V   EPP   V  E     V+S  G        +SG P   + WYK+ +
Sbjct: 3224 R--NRSSVTLYVNAPEPP--QVLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKEEQ 3277

Query: 1308 RLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL----VSVEEPLLVK-- 1361
             L++  + +    G    L +  A   DA  Y C+A  D  +      +SVE P +V   
Sbjct: 3278 LLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPD 3337

Query: 1362 ---------LVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGS 1412
                     +++ L      EG  A F+C VS  D  V+W      + P     M Q   
Sbjct: 3338 QEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFED 3397

Query: 1413 SRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLFLRRLQDVRAEEGQDVCL 1468
            +  L +      D GT T  A    G  +++A L +   E +   R++     E +++  
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKELFS 3457

Query: 1469 EVET 1472
            E E+
Sbjct: 3458 EGES 3461



 Score =  129 bits (324), Expect = 3e-29
 Identities = 238/1189 (20%), Positives = 420/1189 (35%), Gaps = 219/1189 (18%)

Query: 43   VVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVL 102
            V+W    +++  S +    A G  + L +   +  D G Y       AGE   +  +TV 
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTF----YAGENMTSGKLTVA 2618

Query: 103  EPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWE 162
                S P                     LT    Q V    E V  C     P+    W 
Sbjct: 2619 GGAISKP---------------------LT---DQTVAESQEAVFECEVAN-PDSKGEWL 2653

Query: 163  KDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGA 222
            +DG          H  L      +  G    L I A +L D G Y          ++  A
Sbjct: 2654 RDG---------KHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVAT----SKTSA 2700

Query: 223  LLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWE 282
             L+V                     +K   K   V E + A F   +       ++W   
Sbjct: 2701 KLKVE-----------------AVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKN 2743

Query: 283  GRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLR 342
            G  +L    +     +   + L++  C   D  +Y        G+  ++ +LHV+   ++
Sbjct: 2744 G-VVLESNEKYAISVKGTIYSLRIKNCAIVDESVY----GFRLGRLGASARLHVE--TVK 2796

Query: 343  FTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRL 402
              +  +DV   E+     E  V +  +P  WF +   + P  K+  + E  V +L++  +
Sbjct: 2797 IIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNI 2856

Query: 403  KADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWS 462
               D G Y   + G++   A + V+   + +  + ++V E + A    E     V   W 
Sbjct: 2857 SPSDAGEYTAVV-GQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSMWL 2915

Query: 463  RDGEELPVICQSS---SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
            ++G E+ +  +      G +H L++   + ED+ E TF  GN + +  L V  +  +   
Sbjct: 2916 KNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSML 2975

Query: 520  PPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPG 579
              I AE     K+T+  T++         + +     E+ S D  Q  + +   ++ +  
Sbjct: 2976 KDINAE----EKDTI--TFEVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRN 3029

Query: 580  DCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDL 639
                   DY F    V+G   S   ++  + H+         ++D++V + + A+F  ++
Sbjct: 3030 VHFGDAADYTF----VAGKATSTATLYVEARHI----EFRKHIKDIKVLEKKRAMFECEV 3081

Query: 640  S-TIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFS 698
            S   I   W  + +EL+  +          R +I+++   HRL++ + +  D+G      
Sbjct: 3082 SEPDITVQWMKDDQELQITD----------RIKIQKEKYVHRLLIPSTRMSDAGKYT-VV 3130

Query: 699  CPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDG----Q 754
              G   +A L ++   V I S +  V +     +R V+  E++  D  A WYKDG     
Sbjct: 3131 AGGNVSTAKLFVEGRDVRIRSIKKEVQV--IEKQRAVVEFEVNEDDVDAHWYKDGIEINF 3188

Query: 755  KVEESELLVVKMDGRKHRLILPEAKVQDSGE--FECRTEGVSAFFGVTVQDPPVHIVDPR 812
            +V+E    VV  + R HR+ + E +  D+GE  F       S    V   +PP  ++   
Sbjct: 3189 QVQERHKYVV--ERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPP-QVLQEL 3245

Query: 813  EHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPS 872
            + V V +        A    R    + WYK+ Q +         ++G    L+L    P 
Sbjct: 3246 QPVTVQS-GKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3304

Query: 873  DGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWT 932
            D   + C A ++   + V  T  S  +  P                  E+  P       
Sbjct: 3305 DAAVYTCEAKND---YGVATTSASLSVEVP------------------EVVSP------- 3336

Query: 933  KDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIY 992
             D E  V  PA++   +DTV     PA        + C +                    
Sbjct: 3337 -DQEMPVYPPAIITPLQDTVTSEGQPA-------RFQCRV-------------------- 3368

Query: 993  PRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQ 1052
                                 S  D  V WY    +++ S    + +     +L +  A 
Sbjct: 3369 ---------------------SGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAY 3407

Query: 1053 PEDGGEFVCDA----GDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPA 1108
            PED G +   A    G  S+   +++ AP   +     + +++        EL  E    
Sbjct: 3408 PEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEM-----KELFSEGESE 3462

Query: 1109 GSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAE 1168
             S+        + E  D   + A+     ++   + P    EY   +  + +TF  +L  
Sbjct: 3463 HSERDTRDAFSDSEDIDHKSMAAKRYASRISSTSSWP----EYFKPSFTQKLTFKYVL-- 3516

Query: 1169 PPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEG 1216
                               GEPVV +C L     P + W HN RP+  G
Sbjct: 3517 ------------------EGEPVVFTCRLIACPTPEMTWFHNNRPIPTG 3547



 Score =  116 bits (290), Expect = 2e-25
 Identities = 219/1074 (20%), Positives = 389/1074 (36%), Gaps = 173/1074 (16%)

Query: 840  WYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            W+ DGQ++  + +  VV++ +G    +++PAT PSD GE+  VA +     ++++     
Sbjct: 1490 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPAT-PSDSGEWTVVAQNRAGRSSISVILTVE 1548

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVL 957
             + +    ++V  ++   +    E  R   +VR T +    +    + L+  D +     
Sbjct: 1549 AVEHQVKPMFVEKLKNVNIK---EGSRLEMKVRATGNPNPDI----VWLKNSDIIVPHKY 1601

Query: 958  PAVQLEDS-GEYLCEID----DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
            P +++E + GE   +ID     +SA +T T      R      + T   V +E       
Sbjct: 1602 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGR------DTTRCKVNVEV------ 1649

Query: 1013 LSREDAPVRWYKDGLEVEESEALVLERDGPRCR-LVLPAAQP---------EDGGEFVCD 1062
                        +  E E    L++ R   R + +  P  +P          + G+    
Sbjct: 1650 ------------EFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDK 1697

Query: 1063 AGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGL 1119
                  FF   +T+   +   PA      HF         C + P G     V W  DG 
Sbjct: 1698 EKQQKPFFKKKLTSLRLKRFGPA------HF--------ECRLTPIGDPTMVVEWLHDGK 1743

Query: 1120 EVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETT 1179
             +EA++ L++  E    +L    A   D+G   C   ++  T               + T
Sbjct: 1744 PLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGT---------------DHT 1788

Query: 1180 PSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAH 1239
             + L V   + +V   +L            GR     +GL+   E  R          AH
Sbjct: 1789 SATLIVKDEKSLVEESQLP----------EGR-----KGLQRIEELERM---------AH 1824

Query: 1240 AGLYTCQSGAAPGAPSLSFTVQVAEP-PVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGG 1298
             G  T   G             V  P PVRV+  E A+ R R T             P  
Sbjct: 1825 EGALT---GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVT-----------GYPQP 1870

Query: 1299 PVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPL 1358
             V WY +G+ +    R ++   G    L +   +S D GE             V+ E P 
Sbjct: 1871 KVNWYLNGQLIRKSKRFRVRYDGI-HYLDIVDCKSYDTGE-----------VKVTAENP- 1917

Query: 1359 LVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTL 1418
               ++     L + + +D       +P               P P+  + + G  +    
Sbjct: 1918 -EGVIEHKVKLEIQQREDFRSVLRRAP--------------EPRPEFHVHEPGKLQF--- 1959

Query: 1419 RGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAA 1478
                  +   V     +T T   + ++  E +   ++ +   E         E G   A 
Sbjct: 1960 ------EVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 2013

Query: 1479 GAVRWVRGGQPLPHDSRLSMAQDGHIH----RLFIHGVILADQGTYGCESHHDRTLARLS 1534
             AV      +   ++  L   +D  +H            LA++G     +     +  LS
Sbjct: 2014 TAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKI-ELS 2072

Query: 1535 VRPRQLRVLRPLEDVTISEGGSATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIH-SDGH 1592
                  ++   ++  T+ +G  A F++  + +     EW + GV++    + + +  + +
Sbjct: 2073 PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDN 2132

Query: 1593 RHRLVLNGLGLADSG-----CVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT-A 1646
               LV+  +   DS       ++   ++   A  L+  +  +T  +   D+   E DT A
Sbjct: 2133 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMA 2192

Query: 1647 TFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTAR 1706
            TFECE S+    V W KDG  +    + R+ +      L +     SDA  YSC +    
Sbjct: 2193 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE 2252

Query: 1707 --AGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARV 1764
                  +L V    V  + EL+ +   E      EC VS     G+W      L+   + 
Sbjct: 2253 NVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKY 2312

Query: 1765 RIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGR 1824
             I     +  L + ++  ED GE  F     ++   L+++  P+ + +    +K V  G 
Sbjct: 2313 TITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQK-VCEGD 2371

Query: 1825 RAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               LEV VS       W+++G E+ P D+  +     +H L+I D+  ED G Y
Sbjct: 2372 IVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNY 2425



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 95/432 (21%), Positives = 169/432 (39%), Gaps = 71/432 (16%)

Query: 14   FLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            F +  + ++V+    A  +C V  EP   V W K  Q+L  ++R+    +   H LL+ +
Sbjct: 3060 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPS 3118

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
               +DAG Y       AG   + A + V                       EG  V +  
Sbjct: 3119 TRMSDAGKYTV----VAGGNVSTAKLFV-----------------------EGRDVRIRS 3151

Query: 134  PRSQ-WVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASL 192
             + +  V+     V+        +   +W KDG+ ++      H  +   R         
Sbjct: 3152 IKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYVVERRIH------- 3203

Query: 193  ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAP 252
             + I   R  D+G Y   A    G  ++   L V+ P           P  V++ L+  P
Sbjct: 3204 RMFISETRQSDAGEYTFVA----GRNRSSVTLYVNAP----------EPPQVLQELQ--P 3247

Query: 253  KTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAK 312
             T  V  GK A+F   + G+P+P+I W+ E   LL    +  +      + L ++    +
Sbjct: 3248 VT--VQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3304

Query: 313  DRGLYVCAARNSAGQTLSAVQLHVKEPRL------------RFTRPLQDVEGREHGIAVL 360
            D  +Y C A+N  G   ++  L V+ P +                PLQD    E   A  
Sbjct: 3305 DAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3364

Query: 361  ECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY---LCEMRGR 417
            +C+V  + +  +W+ +D+++ P R +   +     +L I     +D+G Y        G+
Sbjct: 3365 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 3424

Query: 418  VRTVANVTVKGP 429
            V + AN++++ P
Sbjct: 3425 VSSTANLSLEAP 3436



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 94/380 (24%), Positives = 137/380 (36%), Gaps = 74/380 (19%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  L+  +PV V SG  A    V+ G P P + W K  Q L+   +  F  DG E+ LL
Sbjct: 3238 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLL 3297

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            L  A P DA VY C A+N  G A  +A+++V  P    P+ +    P          P  
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYP----------PAI 3347

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +T  +      G      CR  G      ++ KD     ++  S  F +   + ED    
Sbjct: 3348 ITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKD----KKIKPSRFFRMT--QFED---- 3397

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPP-------------------- 230
            +  L I  A   D G Y   A NA G   + A L +  P                     
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKELFS 3457

Query: 231  --ESPPADPD------------------EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVM 270
              ES  ++ D                  +  A  +      P+ F  +  +   F+  + 
Sbjct: 3458 EGESEHSERDTRDAFSDSEDIDHKSMAAKRYASRISSTSSWPEYFKPSFTQKLTFKYVLE 3517

Query: 271  GKP-----------EPEIEWHWEGRPLLPDRRRLMYRDRD---GGFVLKVLYCQAKDRGL 316
            G+P            PE+ W    RP+    RR++  + D       L++   Q +D G 
Sbjct: 3518 GEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHHHSSSLEIKRVQDRDSGS 3577

Query: 317  YVCAARNSAGQTLSAVQLHV 336
            Y   A NS G   S   L V
Sbjct: 3578 YRLLAINSEGSAESTASLLV 3597



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 63/239 (26%), Positives = 93/239 (38%), Gaps = 32/239 (13%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            +PP  +   + V V+ G    L+C + G P P V W +   Q+ +S             L
Sbjct: 941  TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARL 1000

Query: 70   LLTAALPTDAGVYVCRARNAAG-------------EAYAAAAVTVLEPPASDPELQPAER 116
            ++  A   D+G + C A N AG             E +      V E   ++ +     R
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1060

Query: 117  PL---------PSPGSGE-GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGM 166
             +            G GE  AP F+T P  Q ++ G  VV  C+ GG P+P +YW+K G+
Sbjct: 1061 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1120

Query: 167  ALDEVWD-SSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL 224
             L   +     +  Q G  +        L I      D+G Y    RN HG   A A L
Sbjct: 1121 PLTTGYRYKVSYNKQTGECK--------LVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 95/398 (23%), Positives = 144/398 (36%), Gaps = 78/398 (19%)

Query: 22   RVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGLLLTAALPTDA 79
            R++ G      C + G P P + W K G+++   ER  + F  DG    L +   LP D 
Sbjct: 1301 RILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVLPEDE 1359

Query: 80   GVYVCRARNAAGEAYAAAAVTV-----LEPPASDPELQPAER------------PL---- 118
            G+Y   A N  G A  +  + V     L  P   P L+P  R            P+    
Sbjct: 1360 GIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSP 1419

Query: 119  -----------------PSPG-----SGEG------APVFLTGPRSQWVLRGAEVVLTCR 150
                              SPG     + E        PVF+  P S   L G       +
Sbjct: 1420 ARMSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLK 1479

Query: 151  AGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCH 210
              G P P  +W  DG  +  V D +H  +     EDG   + +L I+ A   DSG +   
Sbjct: 1480 VVGRPMPETFWFHDGQQI--VNDYTHKVV---IKEDG---TQSLIIVPATPSDSGEWTVV 1531

Query: 211  ARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVM 270
            A+N  G +    +L V        A   +     VE L    K   + EG   + +    
Sbjct: 1532 AQNRAGRSSISVILTVE-------AVEHQVKPMFVEKL----KNVNIKEGSRLEMKVRAT 1580

Query: 271  GKPEPEIEWHWEGRPLLPDR-RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTL 329
            G P P+I W      ++P +  ++      G   LK+    ++D   Y   A N AG+  
Sbjct: 1581 GNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDT 1640

Query: 330  SAVQLHVK------EPRLRFTRPLQDVEGREHGIAVLE 361
            +  +++V+      EP  +   P      +E     LE
Sbjct: 1641 TRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELE 1678



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 118/552 (21%), Positives = 194/552 (35%), Gaps = 105/552 (19%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASER--LSFPADGAEHGL 69
            P F+  P   ++V G      C V G P P V W+K G  L    R  +S+     E  L
Sbjct: 1082 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1141

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL---------PS 120
            +++     DAG Y    RN  GE   +A+ ++LE    +  ++  +  L           
Sbjct: 1142 VISMTFADDAGEYTIVVRNKHGET--SASASLLEEADYELLMKSQQEMLYQTQVTAFVQE 1199

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
            P  GE AP F+     +   +   ++    A        Y E      D+ +  S F   
Sbjct: 1200 PKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE------DQEFHISSF--- 1250

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240
                E+     +  RI+   L +                    L      E    D  E+
Sbjct: 1251 ----EERLIKEIEYRIIKTTLEE--------------------LLEEDGEEKMAVDISES 1286

Query: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
             A V        K + + EG    F C + G P P+I W+ +G+ +    R  M   +DG
Sbjct: 1287 EA-VESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1345

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK--------------EPRLRFTRP 346
               L++     +D G+Y   A N  G  + + +L+V+              EP  R  R 
Sbjct: 1346 RASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRI-RS 1404

Query: 347  LQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADD 406
            L         I +   ++  +R+  A      R+ P R+ E+ +E  + RL         
Sbjct: 1405 LSPRSVSRSPIRMSPARMSPARMSPARM-SPARMSPGRRLEETDESQLERLY-------- 1455

Query: 407  DGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGV-EGRWSRDG 465
                                  P+    P     LEG+ A   ++ +   + E  W  DG
Sbjct: 1456 ---------------------KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDG 1494

Query: 466  EEL-----PVICQSSSGHMHALVLPGVTREDAGEVTF----SLGNSRTTTLLRVKCVKHS 516
            +++       +     G    +++P  T  D+GE T       G S  + +L V+ V+H 
Sbjct: 1495 QQIVNDYTHKVVIKEDGTQSLIIVP-ATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQ 1553

Query: 517  PPGPPILAEMFK 528
                P+  E  K
Sbjct: 1554 V--KPMFVEKLK 1563



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 91/395 (23%), Positives = 142/395 (35%), Gaps = 87/395 (22%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA--EHGL 69
            P F+   + V +  G+  E+K    G P P +VW K    +   +      +G   E  L
Sbjct: 1556 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1615

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP-------- 121
             + + +  D+  Y   A N AG       V V E   ++PE    ER L  P        
Sbjct: 1616 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNV-EVEFAEPE---PERKLIIPRGTYRAKE 1671

Query: 122  -GSGEGAPVFLTGPRSQW------------------------VLRGAEVVLTCRAGGLPE 156
              + E  P+ L   + QW                        + R       CR   + +
Sbjct: 1672 IAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGD 1731

Query: 157  PTLY--WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNA 214
            PT+   W  DG  L+        A +     +    SL   +  +R  DSG+  C A N 
Sbjct: 1732 PTMVVEWLHDGKPLEA-------ANRLRMINEFGYCSLDYGVAYSR--DSGIITCRATNK 1782

Query: 215  HGHAQAGA---------LLQVHQPPESPPA---------------------DPDEAPAPV 244
            +G     A         L++  Q PE                         D  E   P 
Sbjct: 1783 YGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKP- 1841

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRR-RLMYRDRDGGFV 303
               +   P+   V EG+ A+FRC V G P+P++ W+  G+ +   +R R+ Y   DG   
Sbjct: 1842 --DIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHY 1896

Query: 304  LKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
            L ++ C++ D G     A N  G     V+L +++
Sbjct: 1897 LDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1931



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 102/450 (22%), Positives = 150/450 (33%), Gaps = 85/450 (18%)

Query: 7    DQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE 66
            D   PP F+      +V           V G P P V W +    L   ER+     G  
Sbjct: 5178 DNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNV 5237

Query: 67   HGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAER---PLPSPGS 123
              L ++     + G Y+C A N  GEA + A V          ++ P E     LP P +
Sbjct: 5238 CSLEISNIQKGEGGEYMCHAVNIIGEAKSFANV----------DIMPQEERVVALPPPVT 5287

Query: 124  GEGAPVF-LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPG 182
             +    F L    S       E+VL              EKD   + E          P 
Sbjct: 5288 HQHVMEFDLEHTTSSRTPSPQEIVLEVELS---------EKD---VKEFEKQVKIVTVPE 5335

Query: 183  RAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPA 242
               D     ++L +L     D  +    +R          L     PP            
Sbjct: 5336 FTPDHKSMIVSLDVLPFNFVDPNM---DSREGEDKELKIDLEVFEMPPR----------- 5381

Query: 243  PVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGF 302
              + P+ C    F + E   A F+C V+G P PE++W+ E   + PD  + +  +  G  
Sbjct: 5382 -FIMPI-C---DFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKGSH 5436

Query: 303  VLKVLYCQAKDRGLYVCAARNSAGQ------------------------TLSAV------ 332
             LK+      D   Y C A N  G+                        TLS++      
Sbjct: 5437 TLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVL 5496

Query: 333  ---------QLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPC 383
                     +  V E   RF + + D        A  +C V  S  PT ++ +D +L+  
Sbjct: 5497 KSNYTDSFFEFQVVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQG 5556

Query: 384  RKYEQIEEGT-VRRLIIHRLKADDDGIYLC 412
            R++   E GT    L I  L   D+G Y C
Sbjct: 5557 RRFTVEESGTGFHNLFITSLVKSDEGEYRC 5586



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 81/369 (21%), Positives = 132/369 (35%), Gaps = 67/369 (18%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLA--ASERLSFPADGAEHGL 69
            P F+  P   + + G  A     V+G P P   W   GQQ+    + ++    DG +  L
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-SL 1515

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
            ++  A P+D+G +   A+N AG +  +  +TV          +  E  +         P+
Sbjct: 1516 IIVPATPSDSGEWTVVAQNRAGRSSISVILTV----------EAVEHQV--------KPM 1557

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
            F+   ++  +  G+ + +  RA G P P + W K+    D +    +    P    +G  
Sbjct: 1558 FVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS---DIIVPHKY----PKIRIEGTK 1610

Query: 190  ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPAD-----------PD 238
               AL+I +    DS  Y   A N  G       + V      P  +             
Sbjct: 1611 GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAK 1670

Query: 239  EAPAPVVEPLKCAPKTFWVNEG---------------------------KHAKFRCYVMG 271
            E  AP +EPL          EG                            H + R   +G
Sbjct: 1671 EIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIG 1730

Query: 272  KPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
             P   +EW  +G+P L    RL   +  G   L      ++D G+  C A N  G   ++
Sbjct: 1731 DPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTS 1789

Query: 332  VQLHVKEPR 340
              L VK+ +
Sbjct: 1790 ATLIVKDEK 1798



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 60/241 (24%), Positives = 80/241 (33%), Gaps = 46/241 (19%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P  ++G ++  V+ G  V L C   G P PT+ W ++   ++   D      Q G A   
Sbjct: 943  PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIAR-- 999

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE---------------- 231
                  L I  A   DSG + C A N  G       L V    E                
Sbjct: 1000 ------LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1053

Query: 232  -----------------SPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPE 274
                                A P E  AP         K     EG    F C V G P+
Sbjct: 1054 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV---EGGSVVFGCQVGGNPK 1110

Query: 275  PEIEWHWEGRPLLPD-RRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQ 333
            P + W   G PL    R ++ Y  + G   L +    A D G Y    RN  G+T ++  
Sbjct: 1111 PHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASAS 1170

Query: 334  L 334
            L
Sbjct: 1171 L 1171



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 69/279 (24%), Positives = 113/279 (40%), Gaps = 54/279 (19%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE----RLSFPADGAEH 67
           P F +  + V V+ G+ A  +  + G P P V W + GQ ++ S     ++SF    A+ 
Sbjct: 6   PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK- 64

Query: 68  GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            L + A    ++G Y  +A N +G+A + A + V    A                     
Sbjct: 65  -LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA--------------------P 103

Query: 128 PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
           P F+   +S  V +G++V L  R  G+P P + + +DG    E+  S  F +        
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGA---EIQSSLDFQISQ------ 154

Query: 188 PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
            G   +L I  A   DSG Y  +A N+ G A + A L V    E P            + 
Sbjct: 155 EGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVP-----------AKK 203

Query: 248 LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            K    T  ++E +  +         E +IE H++ R +
Sbjct: 204 TKTIVSTAQISESRQTRI--------EKKIEAHFDARSI 234



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 59/232 (25%), Positives = 87/232 (37%), Gaps = 27/232 (11%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE-RLSFPADGAEHGL 69
            PP F+      ++   ++A  KC V+G P P V W K    +     +     +   H L
Sbjct: 5379 PPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKGSHTL 5438

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSG----- 124
             +     +D+  Y CRA N  GEA     +T+ +        + ++  L S         
Sbjct: 5439 KIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKS 5498

Query: 125  ------------EGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVW 172
                        EG P F+ G    +   G      C   G P PT+YW KDG    ++ 
Sbjct: 5499 NYTDSFFEFQVVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDG----KLV 5554

Query: 173  DSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL 224
                F ++    E G G    L I +    D G Y C A N  G A++ A L
Sbjct: 5555 QGRRFTVE----ESGTGFH-NLFITSLVKSDEGEYRCVATNKSGMAESFAAL 5601



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 44/164 (26%), Positives = 77/164 (46%), Gaps = 10/164 (6%)

Query: 1366 LTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPG--PQVEMAQNGSSRILTLRGCQ 1422
            L  + V EG  ATF   +S  P  +V+W R+G V++    P V+++ +     LT+    
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVT 71

Query: 1423 LGDAGTVTLRA----GSTATSARLHVRETELL--FLRRLQDVRAEEGQDVCLEVETGRVG 1476
              ++G  +L+A    G   ++A L V+       F++RLQ +   +G  V L+V    + 
Sbjct: 72   KANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIP 131

Query: 1477 AAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
                V++ R G  +       ++Q+G ++ L I      D GTY
Sbjct: 132  TP-VVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTY 174



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 39/141 (27%), Positives = 67/141 (47%), Gaps = 12/141 (8%)

Query: 1020 VRWYKDGLEVEESE--ALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV--- 1074
            V W++DG  +  S    + +     R +L +PA    + G +   A + S   T T    
Sbjct: 37   VSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELL 96

Query: 1075 ----TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 1130
                TAPP  +     +S+ +  G+  R+++R    P    V++Y+DG E+++S   Q+ 
Sbjct: 97   VKAETAPPNFVQR--LQSMTVRQGSQVRLQVRVTGIPT-PVVKFYRDGAEIQSSLDFQIS 153

Query: 1131 AEGPTRTLTLPHAQPEDAGEY 1151
             EG   +L +  A PED+G Y
Sbjct: 154  QEGDLYSLLIAEAYPEDSGTY 174



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 54/214 (25%), Positives = 86/214 (40%), Gaps = 27/214 (12%)

Query: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD-EVWDSSHFALQPGRAE 185
           AP F    +S  VL G+         G P P + W +DG  +          +   GRA+
Sbjct: 5   APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64

Query: 186 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 245
                   L I A    +SG Y   A N  G A + A L V           + AP   V
Sbjct: 65  --------LTIPAVTKANSGRYSLKATNGSGQATSTAELLV---------KAETAPPNFV 107

Query: 246 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 305
           + L    ++  V +G   + +  V G P P ++++ +G  +   +  L ++    G +  
Sbjct: 108 QRL----QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI---QSSLDFQISQEGDLYS 160

Query: 306 VLYCQA--KDRGLYVCAARNSAGQTLSAVQLHVK 337
           +L  +A  +D G Y   A NS G+  S  +L V+
Sbjct: 161 LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 1/92 (1%)

Query: 11   PPCFLR-FPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            PP  L+  P+  R   G    L+C++ GEP PVV W + G  L  +++  F      H L
Sbjct: 4157 PPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQL 4216

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
             +      D+G Y C A N +G   + + +TV
Sbjct: 4217 YIKDVNSQDSGKYKCVAENNSGAVESVSDLTV 4248



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 28/92 (30%), Positives = 48/92 (52%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
           +PP F++  + + V  G++  L+  V G P PVV + + G ++ +S       +G  + L
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSL 161

Query: 70  LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
           L+  A P D+G Y   A N+ G A + A + V
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 195/938 (20%), Positives = 327/938 (34%), Gaps = 198/938 (21%)

Query: 713  SPVHI-LSPQDRVS----LTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKM 766
            +PV I ++P   VS    +T    E V L C +S    P  TWY++  ++E S    +  
Sbjct: 934  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993

Query: 767  DGRKHRLILPEA-------------------------KVQDSGEFECRTEGVSAFFGVT- 800
                 RL++ EA                          VQ S EFE  T  V+  F    
Sbjct: 994  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEE 1053

Query: 801  ---VQDPPVHIVD---------PREHVFVHAITSECV---------MLACEVDREDAP-V 838
               V+   V + D         P E    + IT   V         +  C+V     P V
Sbjct: 1054 KRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV 1113

Query: 839  RWYKDGQEVEESDF--VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTI---- 892
             W K G  +       V    +    +LV+  T   D GE+  V  ++    + +     
Sbjct: 1114 YWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLE 1173

Query: 893  -----------------TDVSSWIVYPS------GKVYVAAVR---LERVVLTCELCRPW 926
                             T V++++  P       G VY    +    E+ ++  ++ +  
Sbjct: 1174 EADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDT 1233

Query: 927  AEVR-WTKDGEEVVESPALLLQKEDTVRRLVLPAVQL-EDSGEYLCEIDDESASFTVTVT 984
              VR + +D E  + S    L KE   R +     +L E+ GE    +D   +    +  
Sbjct: 1234 VVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGF 1293

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLE--RDG 1041
            +  ++     + +         V   C++S    P + WYKDG  ++  E   ++  +DG
Sbjct: 1294 DSRIKNYRILEGMG--------VTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG 1345

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             R  L +P   PED G +   A +             +  V PAA       GAP  +  
Sbjct: 1346 -RASLRIPVVLPEDEGIYTAFASNIKG----NAICSGKLYVEPAA-----PLGAPTYIPT 1395

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT 1161
               V+   S          +  S A    A      ++     P    E   E++ E + 
Sbjct: 1396 LEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERL- 1454

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV---VWSHNGRP-VQEGE 1217
            +  +    PV F  LE   +              +L   G P+    W H+G+  V +  
Sbjct: 1455 YKPVFVLKPVSFKCLEGQTARF------------DLKVVGRPMPETFWFHDGQQIVNDYT 1502

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYT--CQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
               +  E   + L I  A P+ +G +T   Q+ A   + S+  TV+  E  V+ +  E  
Sbjct: 1503 HKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKL 1562

Query: 1276 QTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLA--SQGRVQLEQAGARQVLRVQGAR 1332
            +  V    G  LE+ V  +G P   + W K+ + +      ++++E       L++    
Sbjct: 1563 K-NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTV 1621

Query: 1333 SGDAGEY----LCDAPQDSRIFLVSVE-----------------------------EPLL 1359
            S D+  Y    +  A +D+    V+VE                             EPL 
Sbjct: 1622 SQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLH 1681

Query: 1360 VKLVSE---------------------LTPLTVHEGDDATFRCEVSP---PDADVTWLRN 1395
            ++   E                     LT L +     A F C ++P   P   V WL +
Sbjct: 1682 LRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHD 1741

Query: 1396 GAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLF 1451
            G  +    ++ M        L        D+G +T RA    G+  TSA L V++ + L 
Sbjct: 1742 GKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSL- 1800

Query: 1452 LRRLQDVRAEEGQDVCLEV-ETGRVGAAGAVRWVRGGQ 1488
               +++ +  EG+     + E  R+   GA+  V   Q
Sbjct: 1801 ---VEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQ 1835



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 67/309 (21%), Positives = 111/309 (35%), Gaps = 55/309 (17%)

Query: 139  VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA----------EDGP 188
            +L G  V   C+  G P P + W KDG  +          LQ GRA          ++G 
Sbjct: 1302 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1361

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ----PPESPPADPDEAPAPV 244
              + A  I    +    +YV  A           L  V +     P S    P       
Sbjct: 1362 YTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR 1421

Query: 245  VEPLKCAPK----------------------------------TFWVNEGKHAKFRCYVM 270
            + P + +P                                   +F   EG+ A+F   V+
Sbjct: 1422 MSPARMSPARMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVV 1481

Query: 271  GKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLS 330
            G+P PE  W  +G+ ++ D    +    DG   L ++     D G +   A+N AG++  
Sbjct: 1482 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1541

Query: 331  AVQLHVK----EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRK 385
            +V L V+    + +  F   L++V  +E     ++ +   +  P   W +    ++P  K
Sbjct: 1542 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVP-HK 1600

Query: 386  YEQIE-EGT 393
            Y +I  EGT
Sbjct: 1601 YPKIRIEGT 1609



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 2/92 (2%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAE-HGL 69
            PP F++         G  A  +C+V G P P V W K G+ L    R +    G   H L
Sbjct: 5513 PPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGK-LVQGRRFTVEESGTGFHNL 5571

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
             +T+ + +D G Y C A N +G A + AA+T+
Sbjct: 5572 FITSLVKSDEGEYRCVATNKSGMAESFAALTL 5603



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 48/178 (26%), Positives = 84/178 (47%), Gaps = 13/178 (7%)

Query: 1640 VTEGDTATFECELSQ-ALADVTWEKDGNALTPS--PRLRLQALGTRRLLQLRRCGPSDAG 1696
            V EG TATFE  +S   + +V+W +DG  ++ S  P +++     R  L +     +++G
Sbjct: 17   VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76

Query: 1697 TYSCAV--GTARA-GPVRLTVRERTVA--VLSELRSVSAREGDGATFECTVSEVET-TGR 1750
             YS     G+ +A     L V+  T     +  L+S++ R+G     +  V+ + T   +
Sbjct: 77   RYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVK 136

Query: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVE 1804
            +   G  ++     +I QEG  + L+++E   ED+G     A    G A S A L V+
Sbjct: 137  FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 40/149 (26%), Positives = 68/149 (45%), Gaps = 13/149 (8%)

Query: 925  PWAEVRWTKDGEEVVES--PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVT 982
            P  EV W +DG+ +  S  P + +   D   +L +PAV   +SG Y  +  + S   T T
Sbjct: 33   PVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATST 92

Query: 983  V-------TEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEA 1034
                    T PP   +     +T+   +   V L   ++    PV ++Y+DG E++ S  
Sbjct: 93   AELLVKAETAPP-NFVQRLQSMTVRQGSQ--VRLQVRVTGIPTPVVKFYRDGAEIQSSLD 149

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
              + ++G    L++  A PED G +  +A
Sbjct: 150  FQISQEGDLYSLLIAEAYPEDSGTYSVNA 178



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 52/187 (27%), Positives = 87/187 (46%), Gaps = 19/187 (10%)

Query: 1725 LRSVSAREGDGATFECTVS-----EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSE 1779
            L+SV   EG  ATFE  +S     EV      ++      PG ++    +G+  + + + 
Sbjct: 12   LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDGRAKLTIPAV 70

Query: 1780 LRAEDAGEVRFQA----GPAQSLA--LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS 1833
             +A ++G    +A    G A S A  L++ E  P    +   +  TV  G +  L+V V+
Sbjct: 71   TKA-NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL-QSMTVRQGSQVRLQVRVT 128

Query: 1834 RSGGHVC-WLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTH 1888
                 V  + R+GAE+     +++   G  +SL+I +  PED GTY   A    G+ ++ 
Sbjct: 129  GIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATST 188

Query: 1889 TRLLVEG 1895
              LLV+G
Sbjct: 189  AELLVQG 195



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 62/297 (20%), Positives = 109/297 (36%), Gaps = 33/297 (11%)

Query: 1252 GAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLAS 1311
            G P+ +   +  E P   + P   +    +T  G +  V  L  PG  V+WY++   L  
Sbjct: 5168 GTPNEAIEPKDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPG--VKWYRNKSLLEP 5225

Query: 1312 QGRVQLEQAGARQVLRVQGARSGDAGEYLCDA----------------PQDSRIFLVSVE 1355
              R+++E+ G    L +   + G+ GEY+C A                PQ+ R+  V++ 
Sbjct: 5226 DERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERV--VALP 5283

Query: 1356 EPLLVKLVSEL-----TPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQN 1410
             P+  + V E      T        +     E+S  D      +   V  P    E   +
Sbjct: 5284 PPVTHQHVMEFDLEHTTSSRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVP----EFTPD 5339

Query: 1411 GSSRILTLRGCQLG--DAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCL 1468
              S I++L        D    +           L V E    F+  + D +  E  D   
Sbjct: 5340 HKSMIVSLDVLPFNFVDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVF 5399

Query: 1469 EVETGRVGAAGAVRWVRGGQPL-PHDSRLSMAQDGHIHRLFIHGVILADQGTYGCES 1524
            +     +     V+W +    + P + +  ++++   H L I  V L+D  TY C +
Sbjct: 5400 KCSVIGI-PTPEVKWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRA 5455



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 36/138 (26%), Positives = 56/138 (40%), Gaps = 23/138 (16%)

Query: 1020 VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVT 1075
            V+WY++   +E  E + +ER G  C L +   Q  +GGE++C A    G+  +F  V + 
Sbjct: 5214 VKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIM 5273

Query: 1076 APPERIV-------HPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQ 1128
               ER+V       H      DL      R     E+             LEVE S+   
Sbjct: 5274 PQEERVVALPPPVTHQHVMEFDLEHTTSSRTPSPQEIV------------LEVELSEKDV 5321

Query: 1129 LGAEGPTRTLTLPHAQPE 1146
               E   + +T+P   P+
Sbjct: 5322 KEFEKQVKIVTVPEFTPD 5339



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 17/180 (9%)

Query: 1284 GGDLELVVHLSG-PGGPVRWYKDGERLASQGR--VQLEQAGARQVLRVQGARSGDAGEYL 1340
            G       H+SG P   V W++DG+ +++     VQ+  +  R  L +      ++G Y 
Sbjct: 20   GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79

Query: 1341 CDAPQDSRIFLVSVEEPLLVK-------LVSELTPLTVHEGDDATFRCEVSP-PDADVTW 1392
              A   S     + E  LLVK        V  L  +TV +G     +  V+  P   V +
Sbjct: 80   LKATNGSGQATSTAE--LLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKF 137

Query: 1393 LRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETE 1448
             R+GA +      +++Q G    L +      D+GT ++ A    G   ++A L V+  E
Sbjct: 138  YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEE 197



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 52/231 (22%), Positives = 76/231 (32%), Gaps = 63/231 (27%)

Query: 143  AEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLP 202
            ++ V  C   G+P P + W K+ M ++   D+  + +   +       S  L+I    L 
Sbjct: 5395 SDAVFKCSVIGIPTPEVKWYKEYMCIEP--DNIKYVISEEKG------SHTLKIRNVCLS 5446

Query: 203  DSGVYVCHARNAHGHAQAGALLQV------------------------------------ 226
            DS  Y C A N  G A     L +                                    
Sbjct: 5447 DSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFFE 5506

Query: 227  HQPPESPPA---DPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG 283
             Q  E PP       +  AP+               G  A F+C V G P P + W+ +G
Sbjct: 5507 FQVVEGPPRFIKGISDCYAPI---------------GTAAYFQCLVRGSPRPTVYWYKDG 5551

Query: 284  RPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQL 334
            + L+  RR  +     G   L +      D G Y C A N +G   S   L
Sbjct: 5552 K-LVQGRRFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGMAESFAAL 5601



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 52/216 (24%), Positives = 87/216 (40%), Gaps = 29/216 (13%)

Query: 727 TFTTSERVVLTCELSRVDFPA----------TWYKDGQKVEESELLVVKM---DGRKHRL 773
           TFT   + V+  E S   F A          +W++DGQ +  S L  V++   DGR  +L
Sbjct: 7   TFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA-KL 65

Query: 774 ILPEAKVQDSGEFECRTEGVS------AFFGVTVQDPPVHIVDPREHVFVHAITSECVML 827
            +P     +SG +  +    S      A   V  +  P + V   + + V   +   V L
Sbjct: 66  TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ--VRL 123

Query: 828 ACEVDREDAPV-RWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
              V     PV ++Y+DG E++ S    +  EG    L++    P D G +   A +   
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183

Query: 887 YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL 922
             T T        +   G+  V A + + +V T ++
Sbjct: 184 RATSTAE------LLVQGEEEVPAKKTKTIVSTAQI 213



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 119/577 (20%), Positives = 207/577 (35%), Gaps = 118/577 (20%)

Query: 1111 QVRWYKDGLEVEASDALQLG-AEGPTRTLTLPHAQPEDAGEYVC---ETRHEAITFNVIL 1166
            ++ WYKDG  ++  +  Q+   +    +L +P   PED G Y       +  AI    + 
Sbjct: 1321 KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY 1380

Query: 1167 AEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGP 1226
             EP     A      P  +   EPV      SR  +    S +  P++           P
Sbjct: 1381 VEPAAPLGA------PTYIPTLEPV------SRIRSLSPRSVSRSPIRMSPA----RMSP 1424

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGD 1286
             R+       PA         G        S   ++ +P V V+ P + +     T   D
Sbjct: 1425 ARM------SPARMSPARMSPGRRLEETDESQLERLYKP-VFVLKPVSFKCLEGQTARFD 1477

Query: 1287 LELVVHLSGPGGPVRWYKDGERLASQ--GRVQLEQAGARQVLRVQGARSGDAGEYLCDAP 1344
            L++V     P     W+ DG+++ +    +V +++ G + ++ V    S D+GE+   A 
Sbjct: 1478 LKVV---GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPS-DSGEWTVVAQ 1533

Query: 1345 QDSRIFLVSV-------EEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNG 1396
              +    +SV       E  +    V +L  + + EG     +   +  P+ D+ WL+N 
Sbjct: 1534 NRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS 1593

Query: 1397 AVVTPG--PQVEMAQNGSSRILTLRGCQLGDA----GTVTLRAGSTATSARLHVR----- 1445
             ++ P   P++ +        L +      D+     T   +AG   T  +++V      
Sbjct: 1594 DIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAE 1653

Query: 1446 ---ETELLFLR---RLQDVRAEE--------GQDVCLE--------------------VE 1471
               E +L+  R   R +++ A E        GQ+   E                    + 
Sbjct: 1654 PEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1713

Query: 1472 TGRVGAAG-------------AVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQG 1518
              R G A               V W+  G+PL   +RL M  +     L        D G
Sbjct: 1714 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSG 1773

Query: 1519 TYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLE----LSQEG-VT 1569
               C + +    D T A L V+  +  V    E+  + EG     ++E    ++ EG +T
Sbjct: 1774 IITCRATNKYGTDHTSATLIVKDEKSLV----EESQLPEGRKGLQRIEELERMAHEGALT 1829

Query: 1570 G------EWARGGVQLYPGPKCHIHSDGHRHRLVLNG 1600
            G      E  +  + LYP P   +  +  R R  + G
Sbjct: 1830 GVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTG 1866



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 24/99 (24%), Positives = 42/99 (42%), Gaps = 1/99 (1%)

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            PK     EG      C + G+P+P + W   G  LL   ++  + + +    L +    +
Sbjct: 4165 PKHARCREGDSIILECLISGEPQPVVTWFQNG-VLLKQNQKFQFEEVNCSHQLYIKDVNS 4223

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDV 350
            +D G Y C A N++G   S   L V+    R     +++
Sbjct: 4224 QDSGKYKCVAENNSGAVESVSDLTVEPVTYRENSQFENI 4262



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 21/182 (11%)

Query: 1178 TTPSPLCVAPGEPVVL------SCELSRAGAPVV---WSHNGRPVQEGE--GLELHAEGP 1226
            TT +P    P + VV+      + E   +G PV    W  +G+ +      G+++     
Sbjct: 2    TTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDG 61

Query: 1227 RRVLCIQAAGPAHAGLYTCQ----SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRST 1282
            R  L I A   A++G Y+ +    SG A     L    + A PP  V   ++   R    
Sbjct: 62   RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETA-PPNFVQRLQSMTVR---- 116

Query: 1283 PGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
             G  + L V ++G P   V++Y+DG  + S    Q+ Q G    L +  A   D+G Y  
Sbjct: 117  QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176

Query: 1342 DA 1343
            +A
Sbjct: 177  NA 178



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 44/168 (26%), Positives = 71/168 (42%), Gaps = 14/168 (8%)

Query: 1544 RPLEDVTISEGGSATFQLELSQEGVTG-EWARGG----VQLYPGPKCHIHSDGHRHRLVL 1598
            +PL+ V + EG +ATF+  +S   V    W R G        PG +    SDG R +L +
Sbjct: 10   QPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF-SDG-RAKLTI 67

Query: 1599 NGLGLADSGCVSFTADS----LRCAARLIVR--EVPVTIVRGPHDLEVTEGDTATFECEL 1652
              +  A+SG  S  A +        A L+V+    P   V+    + V +G     +  +
Sbjct: 68   PAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRV 127

Query: 1653 SQALADVT-WEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYS 1699
            +     V  + +DG  +  S   ++   G    L +    P D+GTYS
Sbjct: 128  TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 61/249 (24%), Positives = 93/249 (37%), Gaps = 58/249 (23%)

Query: 1614 DSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSP 1672
            ++ R  A + +   P T+V G  ++ V EG++ T EC +S      VTW ++   +  S 
Sbjct: 928  ETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI 987

Query: 1673 RLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTAR-----AGPVRLTVRERTVAV-- 1721
              ++        L +R     D+G ++C+     GT       A  V     + T AV  
Sbjct: 988  DFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047

Query: 1722 ---LSELRSVSAR----------------------------------EGDGATFECTV-S 1743
                 E R V +R                                  EG    F C V  
Sbjct: 1048 KFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGG 1107

Query: 1744 EVETTGRWELGGRPLRPGARVRI---RQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
              +    W+  G PL  G R ++   +Q G+   LV+S   A+DAGE    VR + G   
Sbjct: 1108 NPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECK-LVISMTFADDAGEYTIVVRNKHGETS 1166

Query: 1797 SLALLEVEA 1805
            + A L  EA
Sbjct: 1167 ASASLLEEA 1175



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 46/192 (23%), Positives = 68/192 (35%), Gaps = 46/192 (23%)

Query: 735  VLTCELSRVDFPAT-WYKDGQKVEESEL-LVVKMDGRKHRLILPEAKVQDSGEFECR--- 789
            V  C +  +  P   WYK+   +E   +  V+  +   H L +    + DS  + CR   
Sbjct: 5398 VFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVN 5457

Query: 790  -----------TEGVSAFFGVTVQDPPVHIVDPREHV---------------------FV 817
                       T G S  F V  +   V +    E +                     F+
Sbjct: 5458 CVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEFQVVEGPPRFI 5517

Query: 818  HAITSEC-------VMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPAT 869
              I S+C           C V     P V WYKDG+ V+   F V E+      L + + 
Sbjct: 5518 KGI-SDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTGFHNLFITSL 5576

Query: 870  QPSDGGEFQCVA 881
              SD GE++CVA
Sbjct: 5577 VKSDEGEYRCVA 5588



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 60/295 (20%), Positives = 101/295 (34%), Gaps = 36/295 (12%)

Query: 1628 PVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQ 1686
            P + ++     EV EGD+  F C         VTW  +   +  +    + +L    +L 
Sbjct: 3943 PPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILT 4002

Query: 1687 LRRCGPSDAGTYSCAV----GTARAGPVR---------------------LTVRERTVAV 1721
            L      + G+ +C +    GT +   +                      L   E    V
Sbjct: 4003 LSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDEEEELALV 4062

Query: 1722 LSELR----SVSAREGDGATFECTVSEVETTGRWELGGRP--LRPGARVRIRQEGK--KH 1773
              + +    S+S           T   V  +G  EL   P  ++  A   I ++ K  K 
Sbjct: 4063 FDQAKGAHPSMSQEGQTNLHLLKTNPPVPPSGDTELLSFPVEIQVTAATPIPEQDKESKE 4122

Query: 1774 ILVLSELRAEDAGEVRFQAGPAQSLALL-EVEALPLQMCRHPPREKTVLVGRRAVLEVTV 1832
            +    EL  +   + +    P      L ++   P +M +  P+      G   +LE  +
Sbjct: 4123 VFQTEELEPKAMPQDQVTQSPKHRFVFLSDITNEPPKMLQEMPKHARCREGDSIILECLI 4182

Query: 1833 SRSGGHVC-WLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDS 1886
            S     V  W + G  L    K++      +H L I DV  +D G Y C A  +S
Sbjct: 4183 SGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYKCVAENNS 4237



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 85/394 (21%), Positives = 145/394 (36%), Gaps = 79/394 (20%)

Query: 1481 VRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCES----HHDRTLARLSVR 1536
            V+W R    L  D R+ M + G++  L I  +   + G Y C +       ++ A + + 
Sbjct: 5214 VKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIM 5273

Query: 1537 PRQLRVLR-------------PLEDVTISEGGS---ATFQLELSQEGVTGEWARGGVQLY 1580
            P++ RV+               LE  T S   S      ++ELS++ V  E+ +  V++ 
Sbjct: 5274 PQEERVVALPPPVTHQHVMEFDLEHTTSSRTPSPQEIVLEVELSEKDVK-EFEK-QVKIV 5331

Query: 1581 PGPKCHIHSDGHRHRLV---LNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHD 1637
              P+    +  H+  +V   +      D    S   +       L V E+P   +    D
Sbjct: 5332 TVPE---FTPDHKSMIVSLDVLPFNFVDPNMDSREGEDKELKIDLEVFEMPPRFIMPICD 5388

Query: 1638 LEVTEGDTATFECE-LSQALADVTWEKDGNALTP-SPRLRLQALGTRRLLQLRRCGPSDA 1695
             ++ E   A F+C  +     +V W K+   + P + +  +        L++R    SD+
Sbjct: 5389 FKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDS 5448

Query: 1696 GTYSC----AVG--------TARAGPVRLTVRERTVAVLSEL------------------ 1725
             TY C     VG        T     +   + +++   LS L                  
Sbjct: 5449 ATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEFQ 5508

Query: 1726 ---------RSVS---AREGDGATFECTV-SEVETTGRWELGGRPLRPGARVRIRQEGKK 1772
                     + +S   A  G  A F+C V      T  W   G+ L  G R  + + G  
Sbjct: 5509 VVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGK-LVQGRRFTVEESGTG 5567

Query: 1773 -HILVLSELRAEDAGEVRF----QAGPAQSLALL 1801
             H L ++ L   D GE R     ++G A+S A L
Sbjct: 5568 FHNLFITSLVKSDEGEYRCVATNKSGMAESFAAL 5601



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 6/112 (5%)

Query: 231  ESPPADPDEAPAPVVEP-----LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
            E+   +    PAPV  P     L    K   V EG+     C++ G P P + W+ E   
Sbjct: 923  EAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 982

Query: 286  LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
             +          + G   L +    A+D G + C+A N AG   ++  L V+
Sbjct: 983  -IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 15/119 (12%)

Query: 1258 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPV-RWYKDGERLASQGRVQ 1316
            F   +   P +++       R R   G  + L   +SG   PV  W+++G  L    + Q
Sbjct: 4149 FLSDITNEPPKMLQEMPKHARCRE--GDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQ 4206

Query: 1317 LEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELT--PLTVHE 1373
             E+      L ++   S D+G+Y C A  +S            V+ VS+LT  P+T  E
Sbjct: 4207 FEEVNCSHQLYIKDVNSQDSGKYKCVAENNSG----------AVESVSDLTVEPVTYRE 4255



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 28/111 (25%), Positives = 46/111 (41%), Gaps = 6/111 (5%)

Query: 1623 IVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGT 1681
            I  E P  +   P      EGD+   EC +S +    VTW ++G  L  + + + + +  
Sbjct: 4153 ITNEPPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNC 4212

Query: 1682 RRLLQLRRCGPSDAGTYSCAVGTARAGPVR----LTVRERTVAVLSELRSV 1728
               L ++     D+G Y C V    +G V     LTV   T    S+  ++
Sbjct: 4213 SHQLYIKDVNSQDSGKYKC-VAENNSGAVESVSDLTVEPVTYRENSQFENI 4262



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 50/188 (26%), Positives = 78/188 (41%), Gaps = 22/188 (11%)

Query: 705  SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVV 764
            SA  + Q+    + +P  + S T   +E   L  +    D P T YK    VE  + + V
Sbjct: 847  SATSSAQKITKSVKAPTVKPSETRVRAEPTPLP-QFPFADTPDT-YKSEAGVEVKKEVGV 904

Query: 765  KMDG---RKHRLIL---PEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVH 818
             + G   R+ R  +    EAKV ++       E         +   P  +V   ++V V 
Sbjct: 905  SITGTTVREERFEVLHGREAKVTETARVPAPVE---------IPVTPPTLVSGLKNVTV- 954

Query: 819  AITSECVMLACEVDREDAP-VRWYKDGQEVEES-DFVVLENEGPHRRLVLPATQPSDGGE 876
             I  E V L C +    +P V WY++  ++E S DF +    G   RL++      D G 
Sbjct: 955  -IEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG-IARLMIREAFAEDSGR 1012

Query: 877  FQCVAGDE 884
            F C A +E
Sbjct: 1013 FTCSAVNE 1020



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 3/92 (3%)

Query: 332  VQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIE 390
            V++ V  P L     L++V   E     LEC +     PT  W+RED ++     ++   
Sbjct: 936  VEIPVTPPTL--VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993

Query: 391  EGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
            +  + RL+I    A+D G + C       TV+
Sbjct: 994  QSGIARLMIREAFAEDSGRFTCSAVNEAGTVS 1025



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 22/84 (26%), Positives = 43/84 (51%), Gaps = 2/84 (2%)

Query: 732  ERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRT 790
            + ++L C +S    P  TW+++G  +++++    +     H+L + +   QDSG+++C  
Sbjct: 4174 DSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYKCVA 4233

Query: 791  EGVSAFFGVTVQDPPVHIVDPREH 814
            E  S     +V D  V  V  RE+
Sbjct: 4234 ENNSGAV-ESVSDLTVEPVTYREN 4256



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/97 (22%), Positives = 36/97 (37%), Gaps = 7/97 (7%)

Query: 247  PLKCAPKTFW------VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
            P +C P          V EG    F C+  G P+P + W+    P +P  +  +    + 
Sbjct: 3939 PQRCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMP-IPRNQNFIIHSLEN 3997

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
              +L +     ++ G   C   N  G   +   L VK
Sbjct: 3998 YSILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVK 4034



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 53/255 (20%), Positives = 96/255 (37%), Gaps = 32/255 (12%)

Query: 805  PVHIVDPREHV----FVHAITS----ECVMLACEVDREDAPV---RWYKDGQEVEESDFV 853
            P   ++P+++     F+  +T     E   L   V+ E  PV   +WY++   +E  + +
Sbjct: 5170 PNEAIEPKDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERI 5229

Query: 854  VLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSWIVY---PSGKV 906
             +E  G    L +   Q  +GGE+ C    + G+  ++  V I      +V    P    
Sbjct: 5230 KMERVGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQ 5289

Query: 907  YVAAVRLE-----------RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRL 955
            +V    LE            +VL  EL     +V+  +   ++V  P      +  +  L
Sbjct: 5290 HVMEFDLEHTTSSRTPSPQEIVLEVELSE--KDVKEFEKQVKIVTVPEFTPDHKSMIVSL 5347

Query: 956  VLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSR 1015
             +      D      E +D+     + V E P R I P  +   I    + V     +  
Sbjct: 5348 DVLPFNFVDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFK-IPENSDAVFKCSVIGI 5406

Query: 1016 EDAPVRWYKDGLEVE 1030
                V+WYK+ + +E
Sbjct: 5407 PTPEVKWYKEYMCIE 5421



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 31/109 (28%), Positives = 45/109 (41%), Gaps = 7/109 (6%)

Query: 229  PPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
            P E+     +E P   +EPL        V E     F   V G P P ++W+     L P
Sbjct: 5170 PNEAIEPKDNEMPPSFIEPLTKRK----VYENTTLGFIVEVEGLPVPGVKWYRNKSLLEP 5225

Query: 289  DRRRLMYRDRDGGFV-LKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
            D R  M  +R G    L++   Q  + G Y+C A N  G+  S   + +
Sbjct: 5226 DERIKM--ERVGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDI 5272



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 18   PRPVRVVSGAEAELKC--------VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            PRP+ ++ G   +  C        V +       VW K GQ++  S+R+    D   H L
Sbjct: 2353 PRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2412

Query: 70   LLTAALPTDAGVY 82
            L+      DAG Y
Sbjct: 2413 LIEDMTKEDAGNY 2425



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 62/271 (22%), Positives = 100/271 (36%), Gaps = 75/271 (27%)

Query: 482  LVLPGVTREDAGEVTFSL----GNSRTTTLLRVKCV-KHSPPGPPI------------LA 524
            L L  V  ++ G +T  L    G  +TT++L+VK   KH      +            LA
Sbjct: 4001 LTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDEEEELA 4060

Query: 525  EMF------------KGHKNTVLLTWKPP-EPAPETPFI-YRLERQEVGS-------EDW 563
             +F            +G  N  LL   PP  P+ +T  + + +E Q   +       ++ 
Sbjct: 4061 LVFDQAKGAHPSMSQEGQTNLHLLKTNPPVPPSGDTELLSFPVEIQVTAATPIPEQDKES 4120

Query: 564  IQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLE 623
             + F  E+     +P D V     +RF              VF       P   L    +
Sbjct: 4121 KEVFQTEELEPKAMPQDQVTQSPKHRF--------------VFLSDITNEPPKMLQEMPK 4166

Query: 624  DVQVYDGEDAVFSLDLSTIIQG------TWFLNGEELKSNEPEGQVEPGALRYRIEQKGL 677
              +  +G+    S+ L  +I G      TWF NG  LK N+          +++ E+   
Sbjct: 4167 HARCREGD----SIILECLISGEPQPVVTWFQNGVLLKQNQ----------KFQFEEVNC 4212

Query: 678  QHRLILHAVKHQDSGALVGFSCPGVQDSAAL 708
             H+L +  V  QDSG    + C    +S A+
Sbjct: 4213 SHQLYIKDVNSQDSGK---YKCVAENNSGAV 4240



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 19/105 (18%)

Query: 1112 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH---EAITF------ 1162
            V+WY++   +E  + +++   G   +L + + Q  + GEY+C   +   EA +F      
Sbjct: 5214 VKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIM 5273

Query: 1163 ----NVILAEPPVQF-----LALETTPSPLCVAPGEPVVLSCELS 1198
                 V+   PPV         LE T S    +P E +VL  ELS
Sbjct: 5274 PQEERVVALPPPVTHQHVMEFDLEHTTSSRTPSPQE-IVLEVELS 5317



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 30/135 (22%), Positives = 51/135 (37%), Gaps = 18/135 (13%)

Query: 101  VLEPPASDPELQPAERPLPSPG---------SGEGAPVFLTGPRSQWVLRGAEVVLTCRA 151
            V +    +P+  P ++   SP          + E   +    P+      G  ++L C  
Sbjct: 4123 VFQTEELEPKAMPQDQVTQSPKHRFVFLSDITNEPPKMLQEMPKHARCREGDSIILECLI 4182

Query: 152  GGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHA 211
             G P+P + W ++G+ L +   +  F  +          S  L I      DSG Y C A
Sbjct: 4183 SGEPQPVVTWFQNGVLLKQ---NQKFQFEE------VNCSHQLYIKDVNSQDSGKYKCVA 4233

Query: 212  RNAHGHAQAGALLQV 226
             N  G  ++ + L V
Sbjct: 4234 ENNSGAVESVSDLTV 4248



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 18/87 (20%), Positives = 38/87 (43%), Gaps = 3/87 (3%)

Query: 796  FFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPV-RWYKDGQEVEESDFVV 854
            F      +PP  + +  +H        + ++L C +  E  PV  W+++G  ++++    
Sbjct: 4149 FLSDITNEPPKMLQEMPKHA--RCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQ 4206

Query: 855  LENEGPHRRLVLPATQPSDGGEFQCVA 881
             E      +L +      D G+++CVA
Sbjct: 4207 FEEVNCSHQLYIKDVNSQDSGKYKCVA 4233



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 4/79 (5%)

Query: 353  REHGIAVLECKVPNSRIPTA-WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYL 411
            RE    +LEC +     P   WF+    L   +K++  E     +L I  + + D G Y 
Sbjct: 4171 REGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYK 4230

Query: 412  C---EMRGRVRTVANVTVK 427
            C      G V +V+++TV+
Sbjct: 4231 CVAENNSGAVESVSDLTVE 4249



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 15/64 (23%), Positives = 35/64 (54%), Gaps = 1/64 (1%)

Query: 1005 ECVVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
            + ++L C +S E  PV  W+++G+ +++++    E      +L +     +D G++ C A
Sbjct: 4174 DSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYKCVA 4233

Query: 1064 GDDS 1067
             ++S
Sbjct: 4234 ENNS 4237



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 31/135 (22%), Positives = 54/135 (40%), Gaps = 5/135 (3%)

Query: 297  DRDGGFVLKVLYCQAKDRG-LYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREH 355
            +R+ G   +  Y   ++RG  Y     +S G    A++    E    F  PL   +  E+
Sbjct: 5138 EREDGTPNEHFYTPTEERGSAYEIWRSDSFGTPNEAIEPKDNEMPPSFIEPLTKRKVYEN 5197

Query: 356  GIAVLECKVPNSRIP-TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC-- 412
                   +V    +P   W+R    L P  + +    G V  L I  ++  + G Y+C  
Sbjct: 5198 TTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHA 5257

Query: 413  -EMRGRVRTVANVTV 426
              + G  ++ ANV +
Sbjct: 5258 VNIIGEAKSFANVDI 5272



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 32/110 (29%), Positives = 49/110 (44%), Gaps = 21/110 (19%)

Query: 424 VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDGE-----ELPVIC 472
           +T + P   +  + + VLEG  A     T EA + G       W RDG+      LP + 
Sbjct: 1   MTTQAPTFTQPLQSVVVLEGSTA-----TFEAHISGFPVPEVSWFRDGQVISTSTLPGVQ 55

Query: 473 QSSSGHMHALVLPGVTREDAG----EVTFSLGNSRTTTLLRVKCVKHSPP 518
            S S     L +P VT+ ++G    + T   G + +T  L VK  + +PP
Sbjct: 56  ISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK-AETAPP 104



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 47/196 (23%), Positives = 80/196 (40%), Gaps = 24/196 (12%)

Query: 343 FTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRL----LPCRKYEQIEEGTVRRL 397
           FT+PLQ V   E   A  E  +    +P  +WFR+ Q +    LP  +     +G  +  
Sbjct: 8   FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQI-SFSDGRAKLT 66

Query: 398 IIHRLKADDD--GIYLCEMRGRVRTVANVTVKG----PILKRLPRKLDVLEGENAVLLVE 451
           I    KA+     +      G+  + A + VK     P   +  + + V +G    L V 
Sbjct: 67  IPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVR 126

Query: 452 TLEAGVEG---RWSRDGEELPVICQ---SSSGHMHALVLPGVTREDAG----EVTFSLGN 501
               G+     ++ RDG E+        S  G +++L++     ED+G      T S+G 
Sbjct: 127 V--TGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR 184

Query: 502 SRTTTLLRVKCVKHSP 517
           + +T  L V+  +  P
Sbjct: 185 ATSTAELLVQGEEEVP 200


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  251 bits (640), Expect = 6e-66
 Identities = 443/1878 (23%), Positives = 695/1878 (37%), Gaps = 214/1878 (11%)

Query: 19   RPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTD 78
            + V+    +   L+C     PPP + W K GQ +  S RL    +G    L +     +D
Sbjct: 2647 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSD 2704

Query: 79   AGVYVCRARNAAGEAYAAAAVTVLEPPASDP--ELQPAERPLPSPGSGEGAPVFLTGPRS 136
            +G Y+C A N AGE      V +  PP      +   A   L       G    +T  R 
Sbjct: 2705 SGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG---VTEYRE 2761

Query: 137  QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMAL---DEVWDSSHFALQPGRAEDGPGASLA 193
              ++      L C    +P P L W ++   L   DEV       LQ GR          
Sbjct: 2762 --IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEV-----SVLQGGR---------V 2805

Query: 194  LRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPK 253
            L+I   R  ++G Y C A N  G       L V  PP     D +E    V         
Sbjct: 2806 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVI-LGDTEELVEEVT-------- 2856

Query: 254  TFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKD 313
               VN       +C  +G P P I W   G P  P  R  +  D   G VL+V   +  D
Sbjct: 2857 ---VNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED---GQVLQVSTAEVAD 2910

Query: 314  RGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW 373
               Y+C A N AG       L V+ P       L+ V    +    L C V     P   
Sbjct: 2911 AASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVT 2970

Query: 374  FREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTV-KGP 429
            + +D + L   +   +  GT   L + R +  D G+Y CE     GR + +  ++V   P
Sbjct: 2971 WYKDSQALSLGEEVFLLPGT-HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPP 3029

Query: 430  ILKRLPR----KLDVLEGENAVLLVETLEAGVEG--RWSRDGEELPVICQSSSGHM--HA 481
              ++ PR     + V  G+ AVL  ET +A  E    W +DG+ L V+ Q +        
Sbjct: 3030 AFRQAPRGPQDAVLVRVGDKAVLSCET-DALPEPTVTWYKDGQPL-VLAQRTQALRGGQR 3087

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP---GPPILAEMFKGHKNTVLLTW 538
            L +      D G  +  + N     +         PP    P             VL   
Sbjct: 3088 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 3147

Query: 539  KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGH 598
                PAP   ++    +  +  E       + + G +++        G Y          
Sbjct: 3148 VSGVPAPTVTWL----KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE 3203

Query: 599  GRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNE 658
             R   VV   +  + P  R      +  V +G++    + L     G    +   LK   
Sbjct: 3204 ARKDFVV---AVLVAPRIRSSGVAREHHVLEGQE----VRLDCEADGQPPPDVAWLKDGS 3256

Query: 659  PEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSC----PGVQDSAALTIQ--E 712
            P GQ     LR+ ++       L+L  ++  D+GA   ++C    P  +D+   T+    
Sbjct: 3257 PLGQDMGPHLRFYLDGGS----LVLKGLRASDAGA---YTCVAHNPAGEDARLHTVNVLV 3309

Query: 713  SPVHILSPQDRVSLTFTTSERVVLTCEL-SRVDFPATWYKDGQKVEESELLVVKMDGRKH 771
             P          +L     E V + C +        +W KDG  +  S+  +  + G  H
Sbjct: 3310 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTL--LHGSGH 3367

Query: 772  RLILPEAKVQDSGEFECRTEGVSAF----FGVTVQDPPVHIVDPRE-HVFVHAITSECVM 826
             L + + ++ D+G F C     +      F + VQ PPV  ++P E    V  +    V 
Sbjct: 3368 TLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPV--LEPVEFQNDVVVVRGSLVE 3425

Query: 827  LACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCV----A 881
            L CE      P V W KDG+ +          +GP   L L A    D G + CV    A
Sbjct: 3426 LPCEARGVPLPLVSWMKDGEPLLSQSL----EQGP--SLQLEAVGAGDSGTYSCVAVSEA 3479

Query: 882  GDECAYFTVTITDVSSWIVYPSGK-VYVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEVV 939
            G+   +F +T+ +     +  SG+   ++      + L C+    P   + W KDG+ + 
Sbjct: 3480 GEARRHFQLTVMEPPH--IEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT 3537

Query: 940  ESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESA----SFTVTVTEPPVRIIYPRD 995
                  L+      R+    +++ D+G Y C  +  +     SF V V  PP  I+ PR 
Sbjct: 3538 R-----LENNSRATRV----LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPP-NIVGPRG 3587

Query: 996  EVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPE 1054
               ++ +    +VL C +  E AP + W++DG+ ++E         G    L L A    
Sbjct: 3588 PRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGR--FLQLQALSTA 3645

Query: 1055 DGGEFVCD----AGDDSAFFTVTV-TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAG 1109
            D G++ C     AG  S  F V + T P  R   PA   +++       +  + +  PA 
Sbjct: 3646 DSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPA---VNVSVNQTALLPCQADGVPA- 3701

Query: 1110 SQVRWYKDGLEVE-ASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAIT----FNV 1164
              V W KD + ++  S   ++  EG   +L +     +DAG Y+C   + A +     ++
Sbjct: 3702 PLVSWRKDRVPLDPRSPRFEILPEG---SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL 3758

Query: 1165 ILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHA 1223
             + EPP    A+  +PS L +    P +L CE S +  P VVW  +G+ +        + 
Sbjct: 3759 RVLEPP----AIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYR 3814

Query: 1224 EGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTP 1283
              P   L + A GP  +  + C      G     + V V  PP   +A +  QT    T 
Sbjct: 3815 LLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPP--TIADD--QTDFTVTM 3870

Query: 1284 GGDLELVVHLSG-PGGPVRWYKDGERLASQGR-VQLEQAGARQVLRVQGARSGDAGEYLC 1341
               + L  H +G P   V W K G +L ++G   ++  +GA   L +  A    AG Y C
Sbjct: 3871 MAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA---LEIGQALPIHAGRYTC 3927

Query: 1342 DAPQDS-----RIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRN 1395
             A   +      +FL     P++  L S +  +   E       CE S  P   +TW + 
Sbjct: 3928 SARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEE---VLLPCEASGIPRPTITWQKE 3984

Query: 1396 GAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRL 1455
            G  V  G   ++   G  RI        G+   +   +  +A      V +   +    L
Sbjct: 3985 GLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGL 4044

Query: 1456 QDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLP-HDSRLSMAQDGHIHRLFIHGVIL 1514
             D+   EG    L  +  R      + W + GQP+   + + ++   G    L +  +  
Sbjct: 4045 PDLSTTEGSHAFLPCK-ARGSPEPNITWDKDGQPVSGAEGKFTIQPSG---ELLVKNLEG 4100

Query: 1515 ADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE--W 1572
             D GTY C + +    AR     R++ +   +  V  +  G  + +L        G+  W
Sbjct: 4101 QDAGTYTCTAENAVGRAR-----RRVHLTILVLPVFTTLPGDRSLRL--------GDRLW 4147

Query: 1573 ARGGVQLYPGPKC-----------HIHSDGHRHRLVLNGLGLADSGCVSFTADS----LR 1617
             R   +  P P+             +        L    +   DSG     A++     +
Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQ 4207

Query: 1618 CAARLIVREVPVTIVRGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRL 1676
              + + V+E PV        L    G +   +C +    + D+ W KDG  L  S  LR 
Sbjct: 4208 AVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGS-HLRH 4266

Query: 1677 QALGTRRLLQLRRCGPSDAGTYSCAVGTAR--AGPVRLTVRERTVAVLSELRSVSAREGD 1734
            Q       L + R    DAG Y C        A  V + V +       E + ++ R GD
Sbjct: 4267 QL--QNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGD 4324

Query: 1735 GATFEC-TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA- 1792
                 C    E   T  W   G+PLR   R+R   +G    L L  +   DAG     A 
Sbjct: 4325 DVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS---LWLENVETGDAGTYDCVAH 4381

Query: 1793 ---GPAQSLALLEVEALP 1807
               G A + A L V   P
Sbjct: 4382 NLLGSATARAFLVVRGEP 4399



 Score =  231 bits (589), Expect = 5e-60
 Identities = 480/2057 (23%), Positives = 747/2057 (36%), Gaps = 317/2057 (15%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP  +  P  V V  G  A L C VLGE P  + W +  + L AS      A  A+  L 
Sbjct: 517  PPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST--GRVAQLADLSLE 573

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            ++  +PTD G Y C A NA G   A+  + V E                       AP  
Sbjct: 574  ISGIIPTDGGRYQCVASNANGVTRASVWLLVRE-----------------------APQV 610

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
                 SQ   +G EV ++C A G P P + W ++  AL E  DS       G        
Sbjct: 611  SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIHVDAQG-------- 660

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
               L I      D+G Y C A N  G  Q    L    PP                 +  
Sbjct: 661  --TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS----------------VSA 702

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
                  V  G+ A   C   G P P + W+  G  +      ++  +      L++   Q
Sbjct: 703  VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM------ILAPEGSSSGKLRIPAAQ 756

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHV-KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRI 369
             +D G Y C A N  G   + +QL V   P+L  T   +DV       A+L C+      
Sbjct: 757  ERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPP 814

Query: 370  PT-AWFREDQRLLPCR-------KYEQIEEGTVRRLIIHRLKADDDGIYLCEMR---GRV 418
            PT  W R D + L  R       +  Q + G    L    +  +D   Y+CE R   G+V
Sbjct: 815  PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV---LFFESVAPEDQAPYVCEARNVFGKV 871

Query: 419  RTVANVTVKG---PILKRLPRKLDVLEGENAVL--LVETLEAGVEGRWSRDGEELPVICQ 473
            +  A + V G   P +      + VLEG+   L  +V       E  W +DG  LP   +
Sbjct: 872  QAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR 931

Query: 474  SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP-------------GP 520
             S     +L L    +E AG  +    N+  +    V+ V   PP             G 
Sbjct: 932  HSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 991

Query: 521  P---------ILAEMFKGHKNTVLLTWKPP-------------EPAPETPFIY------- 551
            P         + A      K T  LT + P             +P+ +    Y       
Sbjct: 992  PASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 1051

Query: 552  --------RLERQEVGSEDWI-QCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSP 602
                    RL    +    ++ + + +  +G++ +    V   G Y    CT S    S 
Sbjct: 1052 VGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYE---CTASNPAGSA 1108

Query: 603  HVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG------TWFLNGEELKS 656
               +     + P  ++  G   ++V  GE    +LDL+ + +G      +W  +G  L+ 
Sbjct: 1109 SHRYVLGVQVPP--QVQPGPRVLKVLVGE----ALDLNCVAEGNPEPQLSWSKDGVVLQG 1162

Query: 657  NEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVH 716
              P+G V                     A++  D+G    + C    +SA +   E  + 
Sbjct: 1163 RGPQGSVH------------------FAAIRTSDAGR---YRCE-ASNSAGVDAWEVELR 1200

Query: 717  ILSP----QDRVS--LTFTTSERVVLTCELSRVDFP-ATWYK--DGQKVEESELLVVKMD 767
            +L P     D  S  L     E   L C       P  TW K    + +     + V  +
Sbjct: 1201 VLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE 1260

Query: 768  GRKHRLILPEAKVQDSGEFECRTE----GVSAFFGVTVQDPPVHIVDPREHVFVHAITSE 823
            G    L L      DSG++EC+        S    + V  PP    D R+   V  +  +
Sbjct: 1261 G---SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRK-ANVSGMAGQ 1316

Query: 824  CVMLACEVDREDAP-VRWYKDGQEV---------------EESDFVVLENEGPHRRLVLP 867
             + L C+ +    P + W KD Q V                +     L +EG  + L  P
Sbjct: 1317 SLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG--QSLHFP 1374

Query: 868  ATQPSDGGEFQCVAGDECA-----YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL 922
              Q  D G + C A ++       +  + +T  S  ++       V  +    V L C  
Sbjct: 1375 RIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS--VLGAGAAQEVLGLAGADVELQCWT 1432

Query: 923  CR-PWAEVRWTKDGEEVVE-SPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDES 976
               P  +V WTKD + V+   P L +Q++  V R+      + D G Y C        ++
Sbjct: 1433 SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT--GSHVGDEGRYQCVAFSPAGQQA 1490

Query: 977  ASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV-LMCELSREDAP-VRWYKDGLEVEESEA 1034
              F + V  PP   I+  +E   +AV  + +V L+CE      P + W+KDG  +  S  
Sbjct: 1491 RDFQLRVHAPPT--IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK 1548

Query: 1035 LVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTAPPERIVHPAARSLD 1090
            +V  R G   +L L  AQ  D G + C A    G       + V  PP  I     R   
Sbjct: 1549 VVYTRGGR--QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP-TIEGAGGRPYV 1605

Query: 1091 LHFGAPGRVELRCEVAPAGS-QVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
            +   A   V L C      S  + W+ +GL V  S+  +L  +G    L  P      +G
Sbjct: 1606 VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESP--GEASSG 1663

Query: 1150 EYVC---ETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV- 1205
             Y C       EA+    +  + P Q L  E       +  G+P+ L C+ S +  P + 
Sbjct: 1664 LYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV-GQPLELPCQASGSPVPTIQ 1722

Query: 1206 WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQV-AE 1264
            W  NGRP +E  G+++ ++G    L I      H+GL+ CQ+    G       V V  E
Sbjct: 1723 WLQNGRPAEELAGVQVASQG--TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGE 1780

Query: 1265 PPVRVVAPEAAQ----TRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQA 1320
                V+     Q        S+     +  VH      P     +G    S G +  E  
Sbjct: 1781 WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEG--WCSPGSLWGEPT 1838

Query: 1321 GARQV------LRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPL--TVH 1372
            G          L+++     D G Y C A   +      V   +LV    E  P+   V 
Sbjct: 1839 GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVL 1898

Query: 1373 EGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTL 1431
            E    T  C  S  P  DV+W +    V+    V ++ +G  R+L +   QL DAG+   
Sbjct: 1899 ENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYRC 1956

Query: 1432 RAGSTA--TSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGA-AGAVRWVRGGQ 1488
             A + A  T  R  +R      +     +      +  + +     GA +  + W++ G 
Sbjct: 1957 VASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN 2016

Query: 1489 PLPHDSR--LSMAQDGHIHRLFIHGVILADQGTYGC-------ESHHDRTLARLSVRPRQ 1539
            P+       L +   G +  L +     +D G Y C       E   D  L ++ + P  
Sbjct: 2017 PVSPAGTPGLQVFPGGRV--LTLASARASDSGRYSCVAVSAVGEDRQDVVL-QVHMPPSI 2073

Query: 1540 LRVLRPLEDVTISEGGSATFQLELSQEGVTG---EWARGGVQLYPGPKCHIHSDGHRHRL 1596
            L      E++ +S   + +  LE     +      W + G  L P P  H+ +D  +  L
Sbjct: 2074 LG-----EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD--KALL 2126

Query: 1597 VLNGLGLADSGCVSFTADSLRCAA------RLIVREVPVTIVRGPHDLEVTEGDTATFEC 1650
             ++   + D+G   +T ++L  A        L V   PV  +R  H L V EG   +  C
Sbjct: 2127 QVDRADVWDAG--HYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSC 2184

Query: 1651 EL-SQALADVTWEKDGNALTPSPRLRLQAL-GTRRLLQLRRCGPSDAGTYSC----AVGT 1704
            E        ++W KDG  L P     LQ +    RLL L +   +  GTY+C     VG 
Sbjct: 2185 ECRGVPFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGN 2243

Query: 1705 ARAG-PVRLTVRERTVAVLSELRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGA 1762
            +     + + V  +          VS  +   AT EC  + +   T  WE  G+P+    
Sbjct: 2244 SSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 2303

Query: 1763 RVRIRQEGKKHILVLSELRAEDAGEVRFQ------AGPAQSLALLEVEALPLQMCRHPPR 1816
             ++++ +G+     L   RA+ A   R+       AG A+    L V  +P ++      
Sbjct: 2304 GLQLQNQGQS----LHVERAQAAHTGRYSCVAENLAGRAERKFELSV-LVPPELIGDLDP 2358

Query: 1817 EKTVLVGRRAVLEVTVSRSG---GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE 1873
               +     + L +     G     + W R    + PG+   + + G    L +   + +
Sbjct: 2359 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG--WMLKMTQTQEQ 2416

Query: 1874 DQGTYCCQAGQDSTHTR 1890
            D G Y C A  ++   R
Sbjct: 2417 DSGLYSCLASNEAGEAR 2433



 Score =  225 bits (574), Expect = 3e-58
 Identities = 463/1997 (23%), Positives = 723/1997 (36%), Gaps = 272/1997 (13%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V V       L C  L  P P + W K G    AS  +        HGL +  A   DAG
Sbjct: 2551 VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP--GTHGLQILNAQKEDAG 2608

Query: 81   VYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVL 140
             Y C   N  GEA     V VL PP+   +                 P+   G +     
Sbjct: 2609 QYTCVVTNELGEAVKNYHVEVLIPPSISKD----------------DPLGEVGVKEVKTK 2652

Query: 141  RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
              + + L C +  +P PT+ W KDG             + P       G    L+I   +
Sbjct: 2653 VNSTLTLECESWAVPPPTIRWYKDGQ-----------PVTPSSRLQVLGEGRLLQIQPTQ 2701

Query: 201  LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV----EPLKCAPKTFW 256
            + DSG Y+C A N  G       + +  PP         A   ++    E      +   
Sbjct: 2702 VSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYRE 2761

Query: 257  VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
            + E   A   C     P P++ W+ E +PL       + +   GG VL++   +A++ G 
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ---GGRVLQIPLVRAENAGR 2818

Query: 317  YVCAARNSAGQTLSAVQLHVKEPR--LRFTRPL-QDVEGREHGIAVLECKVPNSRIPT-A 372
            Y C A N  G+     +L V  P   L  T  L ++V         L+C    + +PT +
Sbjct: 2819 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 2878

Query: 373  WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILK 432
            W +      P  + + +E+G V  L +   +  D   Y+C    +  +   +     +  
Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQV--LQVSTAEVADAASYMCVAENQAGSAEKLFT---LRV 2933

Query: 433  RLPRKLDVLEGENAVLLVET---------LEAGVEGRWSRDGEELPVICQSSSGHMHALV 483
            ++P ++  L+ E    ++ +              E  W +D + L      S G     +
Sbjct: 2934 QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQAL------SLGE-EVFL 2986

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRV-----KCVKHSPPGPPILAEMFKGHKNTVLLTW 538
            LPG      G    S     T   L       K V+ S   PP   +  +G ++ VL+  
Sbjct: 2987 LPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV 3046

Query: 539  K-------PPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFR 591
                      +  PE    +  + Q +      Q  ++     +E+    V  +G Y  +
Sbjct: 3047 GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQ--ALRGGQRLEIQEAQVSDKGLYSCK 3104

Query: 592  ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFL 649
            +  V+G        F  +  + PT       E V    G   V + D+S +     TW  
Sbjct: 3105 VSNVAGEAVR---TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLK 3160

Query: 650  NGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALT 709
            +   ++S+   G V  G             RL L  ++   +G    ++C      A   
Sbjct: 3161 DRMPVESSAVHGVVSRGG------------RLQLSRLQPAQAGT---YTCVAENTQAEAR 3205

Query: 710  IQESPVHILSPQDRVSLT-----FTTSERVVLTCELSRVDFP-ATWYKDGQKV--EESEL 761
                   +++P+ R S           + V L CE      P   W KDG  +  +    
Sbjct: 3206 KDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPH 3265

Query: 762  LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSA----FFGVTVQDPPVHIVDPREHVFV 817
            L   +DG    L+L   +  D+G + C     +        V V  PP           +
Sbjct: 3266 LRFYLDGGS--LVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTL 3323

Query: 818  HAITSECVMLACEVDREDAP--VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
             +   E V + C V R   P  V W KDG  +  S   +L   G    L +   Q +D G
Sbjct: 3324 VSRPGELVTMVCPV-RGSPPIHVSWLKDGLPLPLSQRTLLHGSG--HTLRISKVQLADAG 3380

Query: 876  EFQCVA------GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR-PWAE 928
             F CVA       D      V +  V   + + +    V  VR   V L CE    P   
Sbjct: 3381 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQND---VVVVRGSLVELPCEARGVPLPL 3437

Query: 929  VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVT 984
            V W KDGE       LL Q  +    L L AV   DSG Y C    E  +    F +TV 
Sbjct: 3438 VSWMKDGE------PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM 3491

Query: 985  EPPVRIIYPRDEVTLIAVTLEC-VVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGP 1042
            EPP   I    + T +++T    + L+C+      P + W+KDG      +AL    +  
Sbjct: 3492 EPP--HIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG------QALTRLENNS 3543

Query: 1043 RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGR 1098
            R   VL   +  D G + C     AG     F V V APP  IV P      +   APG+
Sbjct: 3544 RATRVL---RVRDAGLYTCLAESPAGAIEKSFRVRVQAPP-NIVGPRGPRFVVGL-APGQ 3598

Query: 1099 VELRCEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH 1157
            + L C V A    ++ W++DG+ ++     Q    G  R L L      D+G+Y C  R+
Sbjct: 3599 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG--RFLQLQALSTADSGDYSCTARN 3656

Query: 1158 EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQ-E 1215
             A + +V           + + P  + V+  +  +L C+     AP+V W  +  P+   
Sbjct: 3657 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 3716

Query: 1216 GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
                E+  EG  R   IQ      AG Y C +  + G+      ++V EPP   +AP  +
Sbjct: 3717 SPRFEILPEGSLR---IQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPP--AIAPSPS 3771

Query: 1276 Q-TRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERL---ASQGRVQLEQAGARQVLRVQG 1330
              T    TP     L    SG   P V W+KDG++L     QG  +L  + A   L +  
Sbjct: 3772 NLTLTAHTPA---LLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA---LLLTA 3825

Query: 1331 ARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRC-EVSP 1385
                D+ ++ C    +  +  R++ V+V  P    +  + T  TV         C     
Sbjct: 3826 PGPQDSAQFECVVSNEVGEAHRLYQVTVHVP--PTIADDQTDFTVTMMAPVVLTCHSTGI 3883

Query: 1386 PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD-----AGTVTLRAGSTATSA 1440
            P   V+W + GA +        A+    R+      ++G      AG  T  A ++A  A
Sbjct: 3884 PAPTVSWSKAGAQLG-------ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 3936

Query: 1441 RLHVRETELL--FLRRLQD-VRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLS 1497
              HV  T      ++ L   VRA   ++V L  E   +     + W + G  +       
Sbjct: 3937 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI-PRPTITWQKEGLNVATGVSTQ 3995

Query: 1498 MAQDGHIHRLFIHGVILADQGTYGCESHHDRTLA----RLSVRPRQLRVLRPLEDVTISE 1553
            +   G   +L I      D G Y C + +    A    RL V+   + +   L D++ +E
Sbjct: 3996 VLPGG---QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLPDLSTTE 4051

Query: 1554 G----------GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL 1603
            G          GS    +   ++G     A G   + P  +           L++  L  
Sbjct: 4052 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-----------LLVKNLEG 4100

Query: 1604 ADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEK 1663
             D+G  + TA++    AR   R V +TI+  P           T   + S  L D  W +
Sbjct: 4101 QDAGTYTCTAENAVGRAR---RRVHLTILVLP--------VFTTLPGDRSLRLGDRLWLR 4149

Query: 1664 DGNALTPSPRL------RLQALGTRR-----LLQLRRCGPSDAGTYSC----AVGTARAG 1708
                 +P+PR+      R    G         LQ       D+GTY C     VG  +A 
Sbjct: 4150 CAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAV 4209

Query: 1709 PVRLTVRERTVAVLSELRSVSAREGDGATFECTV-SEVETTGRWELGGRPLRPGARVRIR 1767
               + V+E  V        +    G     +C V  +      W   G PLR      +R
Sbjct: 4210 SF-VHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGS---HLR 4265

Query: 1768 QEGKKHILVLSELRAEDAGEVRFQA----GPAQSLALLEVEALPLQMCRHPPREKTVLVG 1823
             + +   L +     +DAG  +  A    G A+ + +L +++ P+      P++ TV  G
Sbjct: 4266 HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVE--PQDMTVRSG 4323

Query: 1824 RRAVLEV-TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
                L           + WL+ G  L    +       P  SL + +V   D GTY C A
Sbjct: 4324 DDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL---PDGSLWLENVETGDAGTYDCVA 4380

Query: 1883 ----GQDSTHTRLLVEG 1895
                G  +    L+V G
Sbjct: 4381 HNLLGSATARAFLVVRG 4397



 Score =  217 bits (552), Expect = 1e-55
 Identities = 482/2065 (23%), Positives = 730/2065 (35%), Gaps = 298/2065 (14%)

Query: 9    GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKG-----GQQLAASE--RLSFP 61
            G  P     PR V V  G  A L C   G PPP V W +G     G +L A    R   P
Sbjct: 783  GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQP 842

Query: 62   ADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP 121
              G    L   +  P D   YVC ARN  G+  A A + V                    
Sbjct: 843  DSGV---LFFESVAPEDQAPYVCEARNVFGKVQAEARLIV-------------------- 879

Query: 122  GSGEGAPVFLTGPRSQWVLRGAEVVLTCRA-GGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
             +G   P   +   +  VL G  V L C    G P P  +W KDG  L            
Sbjct: 880  -TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL------------ 926

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE- 239
            P  +     A  +L +  A    +G Y C A N  G       L V  PP   P      
Sbjct: 927  PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI 986

Query: 240  ------APAPVVEPLKCAPKTFWVNE-------GKH---AKFRCYVMGKPEPE------- 276
                  A  P V     AP   W  E       G H   +K    ++ +P  +       
Sbjct: 987  TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 1046

Query: 277  ----------------------IEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
                                   ++ WE   LLP               L++   Q  D 
Sbjct: 1047 TATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGS------------LRLAQVQVGDS 1094

Query: 315  GLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAV-LECKVPNSRIPTAW 373
            G Y C A N AG       L V+ P     +P   V     G A+ L C    +  P   
Sbjct: 1095 GHYECTASNPAGSASHRYVLGVQVPPQ--VQPGPRVLKVLVGEALDLNCVAEGNPEPQLS 1152

Query: 374  FREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA---NVTVKGPI 430
            + +D  +L  R      +G+V    I   +  D G Y CE        A    + V  P 
Sbjct: 1153 WSKDGVVLQGRG----PQGSVHFAAI---RTSDAGRYRCEASNSAGVDAWEVELRVLEPP 1205

Query: 431  LKRLPRKLDVLE---GENAVLLVE---TLEAGVEGRWSRDGEEL---PVICQSSSGHMHA 481
                     +LE   GENA L      T +  V  R     E L   P +     G   +
Sbjct: 1206 HWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG---S 1262

Query: 482  LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP-----GPPILAEMFKGHKNTVLL 536
            L L  V+  D+G+      N   +T  R K V + PP     G         G   T+  
Sbjct: 1263 LFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLEC 1322

Query: 537  TWKPPEPAPETPFIYRLERQEVGSE----------DWIQCFS---IEKAGAVEVPGDCVP 583
                  P PE   ++  + Q VG             W Q      +++  ++  P     
Sbjct: 1323 DANG-FPVPE--IVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI--- 1376

Query: 584  SEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTII 643
             EGD     C       +    FH      P+       ++V    G D    ++L    
Sbjct: 1377 QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD----VELQCWT 1432

Query: 644  QGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQ 703
             G      E  K  +P   V PG    ++++ G   R+    V  +     V FS  G Q
Sbjct: 1433 SGVPTPQVEWTKDRQP---VLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQ 1489

Query: 704  DSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELL 762
                     +P  I    +   +       V L CE   V  P  TW+KDG  +  S  +
Sbjct: 1490 ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV 1549

Query: 763  VVKMDGRKHRLILPEAKVQDSGEFECR-TEGVSAFFGVTVQD----PPVHIVDPREHVFV 817
            V    GR+  L L  A+  D+G + C+ +  V A    T  D    P +     R +V V
Sbjct: 1550 VYTRGGRQ--LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV-V 1606

Query: 818  HAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGE 876
             A+    V L C      +P + W+ +G  V ES+   LE +G   RL  P    S  G 
Sbjct: 1607 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASS--GL 1664

Query: 877  FQCVA----GDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRW 931
            + CVA    G+    ++V +  V   ++   G   V  +  + + L C+    P   ++W
Sbjct: 1665 YSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 1723

Query: 932  TKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS------------F 979
             ++G    E   + +  + T   L +  V+L+ SG + C+  +E+ +            +
Sbjct: 1724 LQNGRPAEELAGVQVASQGTT--LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 1781

Query: 980  TVTVTEPPV-RIIYPRDEVTLIAVTLECVVLMCELSREDAPV--RWYKDGLEVEESEALV 1036
               V E P+ +  +  +  +      +  V     +    P+   W   G    E   + 
Sbjct: 1782 APGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP 1841

Query: 1037 LERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTAPPERIVHPAARSLDLH 1092
            +    P   L +      D G + C A    G+      + V  PP   + P   +  + 
Sbjct: 1842 VAYSLPP-PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN--IEPGPVNKAVL 1898

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
              A   +E      P    V W+K    V +   + +  +G  R L +  AQ  DAG Y 
Sbjct: 1899 ENASVTLECLASGVPP-PDVSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYR 1955

Query: 1153 CETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWS 1207
            C   + A    + + + +  PP +     + P P+ V    PV L+C  + A +P ++W 
Sbjct: 1956 CVASNVAGSTELRYGLRVNVPP-RITLPPSLPGPVLV--NTPVRLTCNATGAPSPTLMWL 2012

Query: 1208 HNGRPVQEG--EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEP 1265
             +G PV      GL++   G  RVL + +A  + +G Y+C + +A G       +QV  P
Sbjct: 2013 KDGNPVSPAGTPGLQVFPGG--RVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMP 2070

Query: 1266 PVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPV-RWYKDGERLASQGRVQLEQAGARQ 1324
            P   +  E     V +     LE   H   P  PV  W+KDG  L  +  V L  +  + 
Sbjct: 2071 P--SILGEELNVSVVANESVALECQSHAMPP--PVLSWWKDGRPLEPRPGVHL--SADKA 2124

Query: 1325 VLRVQGARSGDAGEYLCD----APQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
            +L+V  A   DAG Y C+    A    + + ++V    +  L  E   LTV EG   +  
Sbjct: 2125 LLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPL-RESHTLTVREGHPTSLS 2183

Query: 1381 CEV-SPPDADVTWLRNGAVVTPGPQVEMAQ-NGSSRILTLRGCQLGDAGTVTLR----AG 1434
            CE    P   ++W ++G  + PG    +   +   R+L L   QL   GT T       G
Sbjct: 2184 CECRGVPFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG 2242

Query: 1435 STATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVG-AAGAVRWVRGGQPLPHD 1493
            +++   +L V     +   R    +    QD    +E    G     V W R GQP+  +
Sbjct: 2243 NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE 2302

Query: 1494 SRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLAR------LSVRPRQLRVLRPLE 1547
              L +   G    L +     A  G Y C + +    A       + V P  +  L PL 
Sbjct: 2303 LGLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLT 2360

Query: 1548 DVTISEGGSATFQLE-LSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADS 1606
            ++T +     T   E +        W RG   + PG   ++ + G    L +      DS
Sbjct: 2361 NITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG--WMLKMTQTQEQDS 2418

Query: 1607 GCVSFTADSLRCAARLIVREVPVTIVRGP----HDLE----VTEGDTATFECELS-QALA 1657
            G  S  A +    AR   R   V ++  P     DLE    V +G TA   C ++     
Sbjct: 2419 GLYSCLASNEAGEAR---RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 2475

Query: 1658 DVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRER 1717
             +TW KDG  L       +   G   LLQ+ +   S AG YSC    A    V    +  
Sbjct: 2476 KLTWFKDGRPLARGDAHHISPDGV--LLQVLQANLSSAGHYSCIAANA----VGEKTKHF 2529

Query: 1718 TVAVLSELRSVSAREGDGATFECTVSEVETTG-------------RWELGGRPLRPGARV 1764
             ++VL     +   E D A  E TV+                    W   G P      +
Sbjct: 2530 QLSVLLAPTILGGAE-DSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNI 2588

Query: 1765 RIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVEALPLQMCRHPP----- 1815
            ++      H L +   + EDAG+    V  + G A     +EV  +P  + +  P     
Sbjct: 2589 QLLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV-LIPPSISKDDPLGEVG 2645

Query: 1816 -REKTVLVGRRAVLEV-TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE 1873
             +E    V     LE  + +     + W ++G  + P  + ++   G    L I   +  
Sbjct: 2646 VKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVS 2703

Query: 1874 DQGTYCC----QAGQDSTHTRLLVE 1894
            D G Y C     AG+D     +L++
Sbjct: 2704 DSGRYLCVATNVAGEDDQDFNVLIQ 2728



 Score =  217 bits (552), Expect = 1e-55
 Identities = 326/1314 (24%), Positives = 516/1314 (39%), Gaps = 156/1314 (11%)

Query: 681  LILHAVKHQDSGALVGFSCPGV----QDSAALTIQ-ESPVHILSPQDRVSLTFTTSERVV 735
            L L + +  DSG    +SC  V    +D   + +Q   P  IL  +  VS+    +E V 
Sbjct: 2035 LTLASARASDSGR---YSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVV--ANESVA 2089

Query: 736  LTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVS 794
            L C+   +  P  +W+KDG+ +E    + +  D  K  L +  A V D+G + C     +
Sbjct: 2090 LECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD--KALLQVDRADVWDAGHYTCEALNQA 2147

Query: 795  AF----FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEE 849
                  + + V   PV  +  RE   +         L+CE      P + W KDGQ +  
Sbjct: 2148 GHSEKHYNLNVWVAPVFPL--RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPG 2205

Query: 850  SDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSWIVYP-SG 904
                +       R L L   Q +  G + C    V G+      + +  V   I  P   
Sbjct: 2206 EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV-HVPPQIAGPREP 2264

Query: 905  KVYVAAVRLERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLE 963
               V+ V+     L C    +P   V W +DG+ V     L LQ +   + L +   Q  
Sbjct: 2265 PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG--QSLHVERAQAA 2322

Query: 964  DSGEYLCEIDDESA----SFTVTVTEPPVRIIYPRDEVTLIAVTLEC-VVLMCELSREDA 1018
             +G Y C  ++ +      F ++V  PP  +I   D +T I   L   + L+CE      
Sbjct: 2323 HTGRYSCVAENLAGRAERKFELSVLVPP-ELIGDLDPLTNITAALHSPLTLLCEAMGIPP 2381

Query: 1019 P-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVT 1073
            P +RW++    V   E   L   G    L +   Q +D G + C    +AG+    F+V 
Sbjct: 2382 PAIRWFRGEEPVSPGEDTYLLAGG--WMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 2439

Query: 1074 VTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGS-QVRWYKDGLEVEASDALQLGAE 1132
            V  PP          + +  G      L C V      ++ W+KDG  +   DA  +  +
Sbjct: 2440 VLVPPSIENEDLEEVIKVLDGQTAH--LMCNVTGHPQPKLTWFKDGRPLARGDAHHISPD 2497

Query: 1133 GPTRTLTLPHAQPEDAGEYVC--------ETRHEAITFNVILAEPPVQFLALETTPSPLC 1184
            G    L +  A    AG Y C        +T+H  ++   +L  P +   A ++    + 
Sbjct: 2498 GVL--LQVLQANLSSAGHYSCIAANAVGEKTKHFQLS---VLLAPTILGGAEDSADEEVT 2552

Query: 1185 VAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLY 1243
            V    P+ L CE     +P + W  +G P +    ++L        L I  A    AG Y
Sbjct: 2553 VTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG--THGLQILNAQKEDAGQY 2610

Query: 1244 TCQSGAAPGAPSLSFTVQVAEPP-------VRVVAPEAAQTRVRSTPGGDLELVVHLSGP 1296
            TC      G    ++ V+V  PP       +  V  +  +T+V ST   + E     + P
Sbjct: 2611 TCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECE---SWAVP 2667

Query: 1297 GGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAP----QDSRIFLV 1352
               +RWYKDG+ +    R+Q+   G  ++L++Q  +  D+G YLC A     +D + F V
Sbjct: 2668 PPTIRWYKDGQPVTPSSRLQV--LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 2725

Query: 1353 SVEEPLLVKLVSELTPL------------------TVHEGDDATFRCEVSP-PDADVTWL 1393
             ++ P + + V + +                     + E + A   C+ +  P  D+TW 
Sbjct: 2726 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 2785

Query: 1394 RNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFL- 1452
            R    ++ G +V + Q G  R+L +   +  +AG  + +A +      LH    ELL L 
Sbjct: 2786 REDQPLSAGDEVSVLQGG--RVLQIPLVRAENAGRYSCKASNEVGEDWLHY---ELLVLT 2840

Query: 1453 ---------RRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGH 1503
                       +++V       V L+           + W++ G P     RL + +DG 
Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPA-LGNPVPTISWLQNGLPFSPSPRLQVLEDGQ 2899

Query: 1504 IHRLFIHGVILADQGTYGCESHHDRTLA------RLSVRPRQLRVLRPLEDVTISEGGSA 1557
            +  L +    +AD  +Y C + +    A      R+ V PR   +   LE VT     S 
Sbjct: 2900 V--LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGL--DLEQVTAILNSSV 2955

Query: 1558 TFQLEL-SQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSL 1616
            +   ++ +       W +    L  G +  +      H L L    L+DSG   +T ++L
Sbjct: 2956 SLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG--THTLQLGRARLSDSGM--YTCEAL 3011

Query: 1617 RCAAR--------LIVREVPVTIVRGPHD-LEVTEGDTATFECELSQALAD--VTWEKDG 1665
              A R        ++V        RGP D + V  GD A   CE + AL +  VTW KDG
Sbjct: 3012 NAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE-TDALPEPTVTWYKDG 3070

Query: 1666 NALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVR---LTVRERTVAVL 1722
              L  + R   QAL   + L+++    SD G YSC V       VR   LTV+       
Sbjct: 3071 QPLVLAQRT--QALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFEN 3128

Query: 1723 SELRSVSAREGDGATFECTVSEVET-TGRWELGGRPLRPGARVRIRQEGKKHILVLSELR 1781
             +  +VS   G      C VS V   T  W     P+   A   +   G +  L LS L+
Sbjct: 3129 PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGR--LQLSRLQ 3186

Query: 1782 AEDAGEVRFQAGPAQSLA----LLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS-RSG 1836
               AG     A   Q+ A    ++ V   P        RE  VL G+   L+     +  
Sbjct: 3187 PAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPP 3246

Query: 1837 GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCC----QAGQDS 1886
              V WL++G+ L       +R +    SLV+  +R  D G Y C     AG+D+
Sbjct: 3247 PDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDA 3300



 Score =  182 bits (463), Expect = 2e-45
 Identities = 306/1251 (24%), Positives = 486/1251 (38%), Gaps = 152/1251 (12%)

Query: 734  VVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            V L C  S V  P  +W+K  Q V     + V +DGR  R  + +A++ D+G + C    
Sbjct: 1903 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLR--IEQAQLSDAGSYRCVASN 1960

Query: 793  VSAF----FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEV 847
            V+      +G+ V  PP   + P   +    + +  V L C      +P + W KDG  V
Sbjct: 1961 VAGSTELRYGLRVNVPPRITLPP--SLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPV 2018

Query: 848  EESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWIVYPS 903
              +    L+     R L L + + SD G + CVA    G++     + +    S +    
Sbjct: 2019 SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL---G 2075

Query: 904  GKVYVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQL 962
             ++ V+ V  E V L C+    P   + W KDG  +   P + L  +  +  L +    +
Sbjct: 2076 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL--LQVDRADV 2133

Query: 963  EDSGEYLCEIDDESA----SFTVTVTEPPVRIIYP-RDEVTLIAVTLECVVLMCELSRED 1017
             D+G Y CE  +++      + + V   PV   +P R+  TL         L CE     
Sbjct: 2134 WDAGHYTCEALNQAGHSEKHYNLNVWVAPV---FPLRESHTLTVREGHPTSLSCECRGVP 2190

Query: 1018 AP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCD----AGDDSAFFTV 1072
             P + W KDG  +    A +         L L  AQ    G + C+     G+ S    +
Sbjct: 2191 FPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQL 2250

Query: 1073 TVTAPPERIVHPAARSLDLHFGAPGRVELRCE-VAPAGSQVRWYKDGLEVEASDALQLGA 1131
             V  PP+ I  P      +     G   L C         V W +DG  V A   LQL  
Sbjct: 2251 EVHVPPQ-IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN 2309

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAP 1187
            +G  ++L +  AQ    G Y C   + A      F + +  PP     L+   + +  A 
Sbjct: 2310 QG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTN-ITAAL 2366

Query: 1188 GEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQ 1246
              P+ L CE      P + W     PV  GE   L A G   +L +       +GLY+C 
Sbjct: 2367 HSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG--WMLKMTQTQEQDSGLYSCL 2424

Query: 1247 SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKD 1305
            +    G    +F+V+V  PP   +  E  +  ++   G    L+ +++G P   + W+KD
Sbjct: 2425 ASNEAGEARRNFSVEVLVPP--SIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 2482

Query: 1306 GERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAP----QDSRIFLVSVEEPLLVK 1361
            G  LA      +   G   +L+V  A    AG Y C A     + ++ F +SV   LL  
Sbjct: 2483 GRPLARGDAHHISPDGV--LLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV---LLAP 2537

Query: 1362 LV------SELTPLTVHEGDDATFRCE-VSPPDADVTWLRNGAVVTPGPQVEMAQNGSSR 1414
             +      S    +TV   +  +  CE ++ P  ++TW+++GA       +++     + 
Sbjct: 2538 TILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP--GTH 2595

Query: 1415 ILTLRGCQLGDAG----TVTLRAGSTATSARLHV------RETELLFLRRLQDVRAEEGQ 1464
             L +   Q  DAG     VT   G    +  + V       + + L    +++V+ +   
Sbjct: 2596 GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 2655

Query: 1465 DVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCES 1524
             + LE E+  V     +RW + GQP+   SRL +  +G +  L I    ++D G Y C +
Sbjct: 2656 TLTLECESWAV-PPPTIRWYKDGQPVTPSSRLQVLGEGRL--LQIQPTQVSDSGRYLCVA 2712

Query: 1525 HHDRTLARLSVRPRQLRVLRPLEDVTISEGG-SATFQLELSQEGVTGEWARGGVQLY--- 1580
             +           +   VL  +  +    G  SA F++ LS+E    E ARGGV  Y   
Sbjct: 2713 TN-----VAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI-LSRE----EEARGGVTEYREI 2762

Query: 1581 ---------------PGPKCHIH------SDGHRHRLVLNGLGLADSGCVSFTADSLRCA 1619
                           P P    +      S G    ++  G  L      +  A    C 
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 2822

Query: 1620 A-----------RLIVREVPVTI---VRGPHDLEVTEGDTATFEC-ELSQALADVTWEKD 1664
            A            L+V   PV +        ++ V    T + +C  L   +  ++W ++
Sbjct: 2823 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882

Query: 1665 GNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAG------PVRLTVRERT 1718
            G   +PSP  RLQ L   ++LQ+     +DA +Y C V   +AG       +R+ V  R 
Sbjct: 2883 GLPFSPSP--RLQVLEDGQVLQVSTAEVADAASYMC-VAENQAGSAEKLFTLRVQVPPRI 2939

Query: 1719 VAVLSELRSVSAREGDGATFECTV-SEVETTGRWELGGRPLRPGARVRIRQEGKKHILVL 1777
              +  +L  V+A      +  C V +       W    + L  G  V +      H L L
Sbjct: 2940 AGL--DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP--GTHTLQL 2995

Query: 1778 SELRAEDAG----EVRFQAGPAQSLALLEVEALPL--QMCRHPPREKTVLVGRRAVLEV- 1830
               R  D+G    E    AG  Q L  L V   P   Q  R P     V VG +AVL   
Sbjct: 2996 GRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 3055

Query: 1831 TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQ 1881
            T +     V W ++G  L    + +    G    L I + +  D+G Y C+
Sbjct: 3056 TDALPEPTVTWYKDGQPLVLAQRTQALRGG--QRLEIQEAQVSDKGLYSCK 3104



 Score =  168 bits (425), Expect = 5e-41
 Identities = 277/1182 (23%), Positives = 433/1182 (36%), Gaps = 165/1182 (13%)

Query: 819  AITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQ 878
            ++T EC  LA  V   D  V W+K  Q V     V +  +G  R L +   Q SD G ++
Sbjct: 1902 SVTLEC--LASGVPPPD--VSWFKGHQPVSSWMGVTVSVDG--RVLRIEQAQLSDAGSYR 1955

Query: 879  CVAGDECAYFTVTI---TDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWTKD 934
            CVA +      +      +V   I  P        V    V LTC     P   + W KD
Sbjct: 1956 CVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP-VRLTCNATGAPSPTLMWLKD 2014

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRI 990
            G  V  +    LQ     R L L + +  DSG Y C     + ++     + V  PP  +
Sbjct: 2015 GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL 2074

Query: 991  IYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVEESEALVLERDGPRCRLVLP 1049
                +E+ +  V  E V L C+      PV  W+KDG  +E    + L  D  +  L + 
Sbjct: 2075 ---GEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD--KALLQVD 2129

Query: 1050 AAQPEDGGEFVCD----AGDDSAFFTVTVTAPPERIVHPAARS--LDLHFGAPGRVELRC 1103
             A   D G + C+    AG     + + V   P   V P   S  L +  G P  +   C
Sbjct: 2130 RADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP---VFPLRESHTLTVREGHPTSLSCEC 2186

Query: 1104 EVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFN 1163
               P   ++ W KDG  +    A         R L L  AQ    G Y CE  +      
Sbjct: 2187 RGVPF-PKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSN------ 2239

Query: 1164 VILAEPPVQFLALETTPSPLCVAPGEPV---------VLSCELSRAGAP---VVWSHNGR 1211
              +     Q L LE    P    P EP          V + E +  G P   V W  +G+
Sbjct: 2240 --VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 2297

Query: 1212 PVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVA 1271
            PV    GL+L  +G  + L ++ A  AH G Y+C +    G     F + V  PP  ++ 
Sbjct: 2298 PVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPP-ELIG 2354

Query: 1272 PEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
                 T + +     L L+    G P   +RW++ GE   S G      AG   +L++  
Sbjct: 2355 DLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR-GEEPVSPGEDTYLLAGG-WMLKMTQ 2412

Query: 1331 ARSGDAGEYLC----DAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS-P 1385
             +  D+G Y C    +A +  R F V V  P  ++       + V +G  A   C V+  
Sbjct: 2413 TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGH 2472

Query: 1386 PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
            P   +TW ++G  +  G    ++ +G   +L +    L  AG  +  A +       H +
Sbjct: 2473 PQPKLTWFKDGRPLARGDAHHISPDGV--LLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 2530

Query: 1446 ETELLFLRRLQDVRAEEGQDVCLEVET-------GRVGAAGAVRWVRGGQPLPHDSRLSM 1498
             + LL    L        ++V + V              +  + W++ G P      + +
Sbjct: 2531 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 2590

Query: 1499 AQDGHIHRLFIHGVILADQGTYGC----------ESHHDRTLARLSVRPRQLRVLRPLED 1548
                  H L I      D G Y C          +++H   L      P  +    PL +
Sbjct: 2591 LPG--THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGE 2643

Query: 1549 VTISE---GGSATFQLELSQEGV---TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
            V + E     ++T  LE     V   T  W + G  + P  +  +  +G    L +    
Sbjct: 2644 VGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQ 2701

Query: 1603 LADSG---CVSFT---------------------ADSLRCAARLIVREVP----VTIVRG 1634
            ++DSG   CV+                             A  ++ RE      VT  R 
Sbjct: 2702 VSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR- 2760

Query: 1635 PHDLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPS 1693
                E+ E + A   C+ +     D+TW ++   L+    + +   G  R+LQ+      
Sbjct: 2761 ----EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRAE 2814

Query: 1694 DAGTYSCAVGT------------ARAGPVRLTVRERTVAVLSELRSVSAREGDGATFEC- 1740
            +AG YSC                    PV L   E  V        V+       + +C 
Sbjct: 2815 NAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELV------EEVTVNASSTVSLQCP 2868

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQ 1796
             +     T  W   G P  P  R+++ ++G+  +L +S     DA         QAG A+
Sbjct: 2869 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVSTAEVADAASYMCVAENQAGSAE 2926

Query: 1797 SLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYE 1855
             L  L V+ +P ++      + T ++     L   V +     V W ++   L  G+  E
Sbjct: 2927 KLFTLRVQ-VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGE--E 2983

Query: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQ----AGQDSTHTRLLV 1893
            +     TH+L +   R  D G Y C+    AG+D    +L V
Sbjct: 2984 VFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 3025



 Score =  151 bits (381), Expect = 7e-36
 Identities = 306/1252 (24%), Positives = 470/1252 (37%), Gaps = 215/1252 (17%)

Query: 778  AKVQDSGEFEC----RTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDR 833
            A   + G +EC    R     A   + V DPP  +V P  +V V     E  +L+C V  
Sbjct: 486  ASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV-PAPNVTVSP--GETAVLSCRVLG 542

Query: 834  EDAP--VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVT 891
            E AP  + W +D + +  S   V +       L +    P+DGG +QCVA +        
Sbjct: 543  E-APYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANG----- 594

Query: 892  ITDVSSWIVY---PSGKVYVAAVRLERVVLTCELCR----PWAEVRWTKDGEEVVESPAL 944
            +T  S W++    P   ++ ++    + V     C     P   + W+++ + + E   +
Sbjct: 595  VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI 654

Query: 945  LLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRIIYPRDEVTLI 1000
             +  + T   L++  V  ED+G Y C    E+  +  + T+  T+PP   +   + V L+
Sbjct: 655  HVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP--SVSAVNAVVLV 709

Query: 1001 AVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRC-RLVLPAAQPEDGGE 1058
            AV  E  VL+CE S    P V WY+ GLE      ++L  +G    +L +PAAQ  D G 
Sbjct: 710  AVGEE-AVLVCEASGVPPPRVIWYRGGLE------MILAPEGSSSGKLRIPAAQERDAGT 762

Query: 1059 FVCDA----GDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRW 1114
            + C A    GD SA   + V   P+    P  R + +  G    +  R    P  + V W
Sbjct: 763  YTCRAVNELGDASAEIQLAVGHAPQLTELP--RDVTVELGRSALLACRATGRPPPT-VTW 819

Query: 1115 YK-DGLEVEASDALQLGAEGPTRT-------LTLPHAQPEDAGEYVCETRH-----EAIT 1161
             + DG  +     L+LGA   +R+       L      PED   YVCE R+     +A  
Sbjct: 820  RRGDGQPL----GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEA 875

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV---WSHNGRPVQEGEG 1218
              ++    P Q  +   T   + V  G+PV L C +  AG P+    W  +GRP+  G  
Sbjct: 876  RLIVTGHAPPQIASSAPT---VRVLEGQPVSLPC-IVLAGRPLPERHWLKDGRPLPPGSR 931

Query: 1219 LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTR 1278
              + A+G    L +  A   HAG Y+C +    G+      + V  PP   + P A  T 
Sbjct: 932  HSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP--RIHPTA--TH 984

Query: 1279 VRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQG-RVQLEQAGARQVLRVQGARSGDA 1336
              +  G    L    SG P   + W K+   L S+G    + + G    L +    + DA
Sbjct: 985  HITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDA 1041

Query: 1337 GEYLCDAPQ----DSRIFLVSVEEPLLVKLVSE---------LTPLTVHEGDDATFRCEV 1383
            G Y+C A       S+   +SV    L K V E         L    V  GD   + C  
Sbjct: 1042 GAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTA 1101

Query: 1384 SPPDAD-----VTWLRNGAVVTPGPQV---------------------EMAQNGSSRILT 1417
            S P        V  ++    V PGP+V                     +++ +    +L 
Sbjct: 1102 SNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQ 1161

Query: 1418 LRGCQ---------LGDAGTVTLRAGSTATSARLHVRETELLFLR-----------RLQD 1457
             RG Q           DAG     A   + SA +   E EL  L             L+ 
Sbjct: 1162 GRGPQGSVHFAAIRTSDAGRYRCEA---SNSAGVDAWEVELRVLEPPHWGADETSGLLER 1218

Query: 1458 VRAEEGQDVCLEVETGRVGAAGAVRWVRG--GQPLPHDSRLSMAQDGHIHRLFIHGVILA 1515
            V  E     C      R      V W +G   +PL     +++ ++G    LF+  V  A
Sbjct: 1219 VAGENASLPC----PARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG---SLFLASVSPA 1271

Query: 1516 DQGTYGCESHHD-----RTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELS------ 1564
            D G Y C++ ++     R    +   P  +R      +V+   G S T + + +      
Sbjct: 1272 DSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE 1331

Query: 1565 --------QEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGL-------ADSGCV 1609
                      GV   WA  G  L  G           HRL+  G  L        DSG  
Sbjct: 1332 IVWLKDAQLVGVPLGWAGYGWDLGWG-------QVGGHRLLDEGQSLHFPRIQEGDSGLY 1384

Query: 1610 SFTADSLRCAAR----LIVREVPVTIVRG-PHDLEVTEGDTATFECELSQA-LADVTWEK 1663
            S  A++    A+    L+V   P  +  G   ++    G     +C  S      V W K
Sbjct: 1385 SCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444

Query: 1664 DGNALTP-SPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRER----- 1717
            D   + P  P L++Q  G  ++L++      D G Y C V  + AG      + R     
Sbjct: 1445 DRQPVLPGGPHLQVQEDG--QVLRITGSHVGDEGRYQC-VAFSPAGQQARDFQLRVHAPP 1501

Query: 1718 TVAVLSELRSVSAREGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKHILV 1776
            T+   +E   V+  E       C    V T    W   G  L    +V   + G++  L 
Sbjct: 1502 TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ--LQ 1559

Query: 1777 LSELRAEDAGEVRFQA----GPAQSLALLEVEALP-LQMCRHPPREKTVLVGRRAVLE-V 1830
            L   ++ DAG    +A    G A+    L+V   P ++     P     + GR   LE V
Sbjct: 1560 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECV 1619

Query: 1831 TVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
                    + W  EG  +   ++  + + G    L +        G Y C A
Sbjct: 1620 ARGHPSPTLSWHHEGLPVAESNESRLETDGSV--LRLESPGEASSGLYSCVA 1669



 Score =  146 bits (368), Expect = 2e-34
 Identities = 416/1840 (22%), Positives = 647/1840 (35%), Gaps = 318/1840 (17%)

Query: 196  ILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTF 255
            IL A   + G Y C A +  G  +A A + V  PP      P   PAP V          
Sbjct: 483  ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP------PQLVPAPNVT--------- 527

Query: 256  WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRG 315
             V+ G+ A   C V+G+    + W  + R L     R+    +     L++      D G
Sbjct: 528  -VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA---QLADLSLEISGIIPTDGG 583

Query: 316  LYVCAARNSAGQTLSAVQLHVKE-PRLRFTRPLQDV-EGREHGIAVLECKVPNSRIPTAW 373
             Y C A N+ G T ++V L V+E P++      Q   +G E  ++      P   I  +W
Sbjct: 584  RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI--SW 641

Query: 374  FREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRV----RTVANVTVKGP 429
             RE Q L    +     +GT   LII  +  +D G Y C+    V     TV       P
Sbjct: 642  SRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 698

Query: 430  ILKRLPRKLDVLEGENAVLLVETLEAGVEGR---WSRDGEELPVICQSSSGHMHALVLPG 486
             +  +   + V  GE AVL+ E   +GV      W R G E+ +  + SS     L +P 
Sbjct: 699  SVSAVNAVVLVAVGEEAVLVCEA--SGVPPPRVIWYRGGLEMILAPEGSSS--GKLRIPA 754

Query: 487  VTREDAGEVTFSLGNSRTTTLLRVK-CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
                DAG  T    N        ++  V H+P    +  ++      + LL  +     P
Sbjct: 755  AQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPP 814

Query: 546  ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV- 604
             T    R + Q +G           + GA        P  G   F   +V+   ++P+V 
Sbjct: 815  PTVTWRRGDGQPLGL----------RLGAGRGSRSRQPDSGVLFFE--SVAPEDQAPYVC 862

Query: 605  -VFHGSAHLVPTARL-VAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNE--PE 660
               +    +   ARL V G    Q+      V  L+   +      L G  L       +
Sbjct: 863  EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 922

Query: 661  GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD-SAALTIQESPVHILS 719
            G+  P   R+ I   G  H L     +H    + V  +  G Q     L +Q  P     
Sbjct: 923  GRPLPPGSRHSIRADGSLH-LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP----- 976

Query: 720  PQDRVSLTFT---TSERV--VLTCELSRVDFPA-TWYKDGQKV-EESELLVVKMDGRKHR 772
               R+  T T   T+E V   L C  S V  P  TW K+   +        V  +G    
Sbjct: 977  ---RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---T 1030

Query: 773  LILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVD 832
            L++ +   QD+G + C       F    ++                 ++   + L+  V 
Sbjct: 1031 LLIAQPSAQDAGAYVCTATNTVGFSSQEMR-----------------LSVNRLALSKYV- 1072

Query: 833  REDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD---ECAYFT 889
                   W + G               P   L L   Q  D G ++C A +     ++  
Sbjct: 1073 -------WEEYGLL-------------PSGSLRLAQVQVGDSGHYECTASNPAGSASHRY 1112

Query: 890  VTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQK 948
            V    V    V P  +V    V  E + L C     P  ++ W+KDG        ++LQ 
Sbjct: 1113 VLGVQVPPQ-VQPGPRVLKVLVG-EALDLNCVAEGNPEPQLSWSKDG--------VVLQG 1162

Query: 949  EDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYP----RDEVT--LIAV 1002
                  +   A++  D+G Y CE    S S  V   E  +R++ P     DE +  L  V
Sbjct: 1163 RGPQGSVHFAAIRTSDAGRYRCE---ASNSAGVDAWEVELRVLEPPHWGADETSGLLERV 1219

Query: 1003 TLECVVLMCELSREDAPVRWYKDGLEVE----ESEALVLERDGPRCRLVLPAAQPEDGGE 1058
              E   L C       P   ++ G   E    +    VLE       L L +  P D G+
Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGS----LFLASVSPADSGD 1275

Query: 1059 FVCDA----GDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEV-APAGSQVR 1113
            + C A    G  S    + V  PP   +    R  ++   A   + L C+       ++ 
Sbjct: 1276 YECQATNEVGSTSRRAKLVVYVPPS--IREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333

Query: 1114 WYKDGLEVEASDA-------LQLGAEGPTR------TLTLPHAQPEDAGEYVCETRHEAI 1160
            W KD   V            L  G  G  R      +L  P  Q  D+G Y C   ++A 
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393

Query: 1161 T----FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQE 1215
            T    F++++  PP   L        L +A G  V L C  S    P V W+ + +PV  
Sbjct: 1394 TAQRDFHLLVLTPP-SVLGAGAAQEVLGLA-GADVELQCWTSGVPTPQVEWTKDRQPVLP 1451

Query: 1216 GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
            G G  L  +   +VL I  +     G Y C + +  G  +  F ++V  PP    + E  
Sbjct: 1452 G-GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETG 1510

Query: 1276 QTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
            +  V       ++L+    G P   + W+KDG  L +  +V   + G +  L++  A+S 
Sbjct: 1511 EVAVME--DHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ--LQLGRAQSS 1566

Query: 1335 DAGEYLCD-------APQDSRIFLV---SVE----EPLLVKLVSELTPLTVHEGDDATFR 1380
            DAG Y C        A + +R+ +    ++E     P +VK V+         G      
Sbjct: 1567 DAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA---------GRPVALE 1617

Query: 1381 CEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATS 1439
            C     P   ++W   G  V    +  +  +GS  +L L       +G  +  A S A  
Sbjct: 1618 CVARGHPSPTLSWHHEGLPVAESNESRLETDGS--VLRLESPGEASSGLYSCVASSPAGE 1675

Query: 1440 ARLHVR-----ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDS 1494
            A L          +LL    L  V    GQ + L  +         ++W++ G+P    +
Sbjct: 1676 AVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASG-SPVPTIQWLQNGRPAEELA 1734

Query: 1495 RLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEG 1554
             + +A  G    L I  V L   G + C++                           +E 
Sbjct: 1735 GVQVASQG--TTLHIDHVELDHSGLFACQA--------------------------TNEA 1766

Query: 1555 GSATFQLELSQEGVTGEWARGGVQLYPG-----------------PKCHIHSDGHRHRLV 1597
            G+A  ++E+S   V GEWA G +++  G                 P  H     H    +
Sbjct: 1767 GTAGAEVEVS---VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPL 1823

Query: 1598 LNG----------------------------LGLADSGCVSFTADSLRCAARLIVR---E 1626
            + G                            + L D G  +  A +L   ++  V     
Sbjct: 1824 VEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL 1883

Query: 1627 VPVTIVRGPHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPRLRLQALGTRRLL 1685
            VP  I  GP +  V E  + T EC  S     DV+W K    ++    + +   G  R+L
Sbjct: 1884 VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RVL 1941

Query: 1686 QLRRCGPSDAGTYSCAVGTARAGP-----VRLTVRERTVAVLSELRSVSAREGDGATFEC 1740
            ++ +   SDAG+Y C              +R+ V  R     S    V        T   
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNA 2001

Query: 1741 TVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLAL 1800
            T +   T   W   G P+ P     ++      +L L+  RA D+G     A  A     
Sbjct: 2002 TGAPSPTL-MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDR 2060

Query: 1801 LEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVC-----------WLREGAELC 1849
             +V  L + M   PP     ++G    + V  + S    C           W ++G  L 
Sbjct: 2061 QDV-VLQVHM---PPS----ILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 2112

Query: 1850 PGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHT 1889
            P     + +      +   DV   D G Y C+A   + H+
Sbjct: 2113 PRPGVHLSADKALLQVDRADV--WDAGHYTCEALNQAGHS 2150



 Score =  143 bits (361), Expect = 1e-33
 Identities = 259/1094 (23%), Positives = 412/1094 (37%), Gaps = 168/1094 (15%)

Query: 15   LRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAA 74
            + F   V VV G+  EL C   G P P+V W K G+ L +      P+      L L A 
Sbjct: 3410 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS------LQLEAV 3463

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
               D+G Y C A + AGEA     +TV+EPP  +   QP E  L                
Sbjct: 3464 GAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTP-------------- 3509

Query: 135  RSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLAL 194
                   GA + L C A G P+P + W KDG AL  + ++S                 A 
Sbjct: 3510 -------GAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR----------------AT 3546

Query: 195  RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKT 254
            R+L  R+ D+G+Y C A +  G  +    ++V  PP             +V P    P+ 
Sbjct: 3547 RVL--RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPN------------IVGPR--GPRF 3590

Query: 255  FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
                        C V  +P P+I WH +G  L  D     + +R  G  L++      D 
Sbjct: 3591 VVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQED-AHTQFPER--GRFLQLQALSTADS 3647

Query: 315  GLYVCAARNSAGQTLSAVQLHVKE-PRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAW 373
            G Y C ARN+AG T  A ++ +   P +R   P  +V   +   A+L C+      P   
Sbjct: 3648 GDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQ--TALLPCQADGVPAPLVS 3705

Query: 374  FREDQRLLPCR--KYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTV-K 427
            +R+D+  L  R  ++E + EG++R   I  + A D G YLC      G  R   ++ V +
Sbjct: 3706 WRKDRVPLDPRSPRFEILPEGSLR---IQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE 3762

Query: 428  GPILKRLPRKLDVLEGENAVLLVETLEAGVE-GRWSRDGEELPVICQSSSGHM---HALV 483
             P +   P  L +     A+L  E   +      W +DG++L    Q  +  +   +AL+
Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 3822

Query: 484  LPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNT-----VLLTW 538
            L     +D+ +    + N         +   H    PP +A+       T     VL   
Sbjct: 3823 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHV---PPTIADDQTDFTVTMMAPVVLTCH 3879

Query: 539  KPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVP-SEGDYRFRICTVSG 597
                PAP     +     ++G+      + +  +GA+E+ G  +P   G Y    C+   
Sbjct: 3880 STGIPAPTVS--WSKAGAQLGARG--SGYRVSPSGALEI-GQALPIHAGRY---TCSARN 3931

Query: 598  HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELK 655
                 H     +    P  + +  +  V+    E+ +   + S I +   TW   G  + 
Sbjct: 3932 SAGVAHKHVFLTVQASPVVKPLPSV--VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVA 3989

Query: 656  SNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSG---ALVGFSCPGVQDSAALTIQE 712
            +      +  G LR            I HA   +D+G    +   S         L +Q 
Sbjct: 3990 TGVSTQVLPGGQLR------------IAHA-SPEDAGNYLCIAKNSAGSAMGKTRLVVQV 4036

Query: 713  SPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESE-LLVVKMDGRK 770
             PV      D   L+ T      L C+      P  TW KDGQ V  +E    ++  G  
Sbjct: 4037 PPVIENGLPD---LSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG-- 4091

Query: 771  HRLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVM 826
              L++   + QD+G + C  E           +T+   PV    P +         + + 
Sbjct: 4092 -ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR---SLRLGDRLW 4147

Query: 827  LACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC-----V 880
            L C       P + W  + + V E    V E +G    L   A    D G + C     V
Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVTEG---VSEQDG-GSTLQRAAVSREDSGTYVCWAENRV 4203

Query: 881  AGDECAYFT------VTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKD 934
               +   F       V   +  S++V P G     +++L+ VV       P  ++ W KD
Sbjct: 4204 GRTQAVSFVHVKEAPVLQGEAFSYLVEPVG----GSIQLDCVVRG----DPVPDIHWIKD 4255

Query: 935  GEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE----SASFTVTVTEPPVRI 990
            G  +  S    L+ +     L +   + +D+G Y C  ++E         + +   PV  
Sbjct: 4256 GLPLRGSH---LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQ 4312

Query: 991  IYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLP 1049
            + P+D   +   + + V L C+ + E  P + W + G  +  S  L    DG    L L 
Sbjct: 4313 VEPQD---MTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG---SLWLE 4366

Query: 1050 AAQPEDGGEFVCDA 1063
              +  D G + C A
Sbjct: 4367 NVETGDAGTYDCVA 4380



 Score =  127 bits (319), Expect = 1e-28
 Identities = 137/470 (29%), Positives = 187/470 (39%), Gaps = 84/470 (17%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA---SERLSFPADGAEH 67
            PP          V   A   L C   G P P V W K G QL A     R+S P+   E 
Sbjct: 3856 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVS-PSGALEI 3914

Query: 68   GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
            G     ALP  AG Y C ARN+AG A+    +TV        +  P  +PLPS       
Sbjct: 3915 G----QALPIHAGRYTCSARNSAGVAHKHVFLTV--------QASPVVKPLPS------- 3955

Query: 128  PVFLTGPRSQWVLRGA---EVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA 184
                       V+R     EV+L C A G+P PT+ W+K+G+    V       + PG  
Sbjct: 3956 -----------VVRAVAEEEVLLPCEASGIPRPTITWQKEGL---NVATGVSTQVLPGG- 4000

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPV 244
                     LRI  A   D+G Y+C A+N+ G A     L V  PP      PD +    
Sbjct: 4001 --------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLS---- 4048

Query: 245  VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVL 304
                          EG HA   C   G PEP I W  +G+P+     +   +   G  ++
Sbjct: 4049 ------------TTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQP-SGELLV 4095

Query: 305  KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV 364
            K L  + +D G Y C A N+ G+    V L +    +  T P  D   R      L C  
Sbjct: 4096 KNL--EGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLP-GDRSLRLGDRLWLRCAA 4152

Query: 365  PNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC--EMR-GRVRTV 421
              S  P   +  + R +     EQ    T++R  + R   +D G Y+C  E R GR + V
Sbjct: 4153 RGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVGRTQAV 4209

Query: 422  ANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVI 471
            + V VK         +  VL+GE    LVE +   ++      G+ +P I
Sbjct: 4210 SFVHVK---------EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDI 4250



 Score =  117 bits (292), Expect = 1e-25
 Identities = 119/430 (27%), Positives = 166/430 (38%), Gaps = 62/430 (14%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP     P  + + +   A L C   G P P+VVW K GQ+L    +         + LL
Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 3822

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            LTA  P D+  + C   N  GEA+    VTV  PP    +       + +P         
Sbjct: 3823 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP--------- 3873

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
                          VVLTC + G+P PT+ W K G  L      S + + P         
Sbjct: 3874 --------------VVLTCHSTGIPAPTVSWSKAGAQLGA--RGSGYRVSP--------- 3908

Query: 191  SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
            S AL I  A    +G Y C ARN+ G A     L V               +PVV+PL  
Sbjct: 3909 SGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ-------------ASPVVKPL-- 3953

Query: 251  APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
             P        +     C   G P P I W  EG   L     +  +   GG  L++ +  
Sbjct: 3954 -PSVVRAVAEEEVLLPCEASGIPRPTITWQKEG---LNVATGVSTQVLPGG-QLRIAHAS 4008

Query: 311  AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP 370
             +D G Y+C A+NSAG  +   +L V+ P +     L D+   E   A L CK   S  P
Sbjct: 4009 PEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV-IENGLPDLSTTEGSHAFLPCKARGSPEP 4067

Query: 371  T-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR---GRVRTVANVTV 426
               W ++ Q +        I+      L++  L+  D G Y C      GR R   ++T+
Sbjct: 4068 NITWDKDGQPVSGAEGKFTIQPS--GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 4125

Query: 427  KG-PILKRLP 435
               P+   LP
Sbjct: 4126 LVLPVFTTLP 4135



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 95/354 (26%), Positives = 132/354 (37%), Gaps = 59/354 (16%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P F   P    +  G    L+C   G P P + W    + +  +E +S    G+   L  
Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPV--TEGVSEQDGGST--LQR 4184

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
             A    D+G YVC A N  G   A + V V E P    E                A  +L
Sbjct: 4185 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGE----------------AFSYL 4228

Query: 132  TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS 191
              P       G  + L C   G P P ++W KDG+ L      SH   Q    ++G    
Sbjct: 4229 VEPV------GGSIQLDCVVRGDPVPDIHWIKDGLPLR----GSHLRHQ---LQNG---- 4271

Query: 192  LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCA 251
             +L I      D+G Y C A N  G A+   +L +   P                  +  
Sbjct: 4272 -SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV----------------FQVE 4314

Query: 252  PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
            P+   V  G     RC   G+P P IEW   G+PL   RR  +    DG   L+ +  + 
Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRR--LRTLPDGSLWLENV--ET 4370

Query: 312  KDRGLYVCAARNSAGQTLSAVQLHVK-EPRLRFTRPLQDVEGREHGIAVLECKV 364
             D G Y C A N  G   +   L V+ EP+  +      + GR+ G+A L   V
Sbjct: 4371 GDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKFGVATLNTSV 4424



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 96/381 (25%), Positives = 137/381 (35%), Gaps = 67/381 (17%)

Query: 74  ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
           A   + G Y C A + AG   A A + V +PP   P+L PA     SPG           
Sbjct: 486 ASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP---PQLVPAPNVTVSPGE---------- 532

Query: 134 PRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193
                       VL+CR  G     L W +D   L             GR      A L+
Sbjct: 533 ----------TAVLSCRVLGEAPYNLTWVRDWRVL---------PASTGRV--AQLADLS 571

Query: 194 LRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPK 253
           L I      D G Y C A NA+G  +A   L V + P+                +     
Sbjct: 572 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----------------VSIHTS 615

Query: 254 TFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKD 313
           +   ++G   K  C   G P P I W  E + L  D R  ++ D  G  +++ +    +D
Sbjct: 616 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQGTLIIQGV--APED 671

Query: 314 RGLYVCAARNSAGQTLSAVQLHVKE-PRLRFTRPLQDVEGREHGIAVLECK-VPNSRIPT 371
            G Y C A N  G     V L+  + P +     +  V   E  + V E   VP  R+  
Sbjct: 672 AGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV-- 729

Query: 372 AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC----EMRGRVRTVANVTVK 427
            W+R    ++        E  +  +L I   +  D G Y C    E+      +      
Sbjct: 730 IWYRGGLEMILAP-----EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH 784

Query: 428 GPILKRLPRKLDVLEGENAVL 448
            P L  LPR + V  G +A+L
Sbjct: 785 APQLTELPRDVTVELGRSALL 805



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 184/770 (23%), Positives = 272/770 (35%), Gaps = 120/770 (15%)

Query: 1186 APGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHA----EGPRRVLCIQAAGPAHAG 1241
            APG   + S EL+++    + +   +P+  G   +L        P+    ++  G  H G
Sbjct: 352  APGR--LDSVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEG 409

Query: 1242 LYTCQ------SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG 1295
                +      SG APGAP +S   ++      +  P      V S     L+L      
Sbjct: 410  NPLLRVSGVSYSGVAPGAPLVSMAPRIHG---YLHQPLLVSCSVHSALPFRLQL------ 460

Query: 1296 PGGPVRWYKDGE-RLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRI----- 1349
                    + GE RL  +   Q     + ++LR   A   + G Y C A   +       
Sbjct: 461  --------RRGEARLGEERHFQESGNSSWEILR---ASKAEEGTYECTAVSRAGTGRAKA 509

Query: 1350 -FLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEM 1407
              +V+   P LV   +    +TV  G+ A   C V      ++TW+R+  V+ P     +
Sbjct: 510  QIVVTDPPPQLVPAPN----VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL-PASTGRV 564

Query: 1408 AQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLFLRRLQDVRAEEG 1463
            AQ      L + G    D G     A    G T  S  L VRE   + +           
Sbjct: 565  AQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ---HFS 620

Query: 1464 QDVCLEVETGRVG-AAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC 1522
            Q V ++V     G     + W R  Q L  DSR+ +   G    L I GV   D G Y C
Sbjct: 621  QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSC 677

Query: 1523 ESHHD-----RTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE---WAR 1574
            ++ ++      T+      P  +  +  +  V ++ G  A    E S  GV      W R
Sbjct: 678  QATNEVGTDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEAS--GVPPPRVIWYR 733

Query: 1575 GGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTA----DSLRCAARLIVREVPVT 1630
            GG+++   P+    S G   +L +      D+G  +  A           +L V   P  
Sbjct: 734  GGLEMILAPEGS--SSG---KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-Q 787

Query: 1631 IVRGPHDLEVTEGDTATFECELS-QALADVTWEK-DGNALTPSPRLRLQA-LGTRR---- 1683
            +   P D+ V  G +A   C  + +    VTW + DG  L     LRL A  G+R     
Sbjct: 788  LTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLG----LRLGAGRGSRSRQPD 843

Query: 1684 --LLQLRRCGPSDAGTYSCAV----GTARAGPVRLTVRERTVAVLSELRSVSAREGDGAT 1737
              +L      P D   Y C      G  +A    +        + S   +V   EG   +
Sbjct: 844  SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 903

Query: 1738 FECTVSEVETTGR------WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ 1791
              C V      GR      W   GRPL PG+R  IR +G  H   L     E AG     
Sbjct: 904  LPCIV----LAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH---LDRALQEHAGRYSCV 956

Query: 1792 AGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSG---GHVCWLRE-GAE 1847
            A         +VE +     R  P     +        +    SG     + W +E  A 
Sbjct: 957  ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNAL 1016

Query: 1848 LCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
               G  Y +   G   +L+I     +D G Y C A    G  S   RL V
Sbjct: 1017 TSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 38/96 (39%), Positives = 46/96 (47%), Gaps = 3/96 (3%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            S P F   P+ + V SG +  L+C   GEP P + W + GQ L AS RL    DG+   L
Sbjct: 4307 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS---L 4363

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPP 105
             L      DAG Y C A N  G A A A + V   P
Sbjct: 4364 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  224 bits (570), Expect = 8e-58
 Identities = 474/1977 (23%), Positives = 710/1977 (35%), Gaps = 403/1977 (20%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKG-GQQLAASERLSFPADGAEHG 68
            S P     P  + V  G  AE +C   G P P + W  G G QL        PA    HG
Sbjct: 1864 SAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQL--------PAKAQIHG 1915

Query: 69   --LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEG 126
              L L A  PTD   Y+CRA ++AG+  A A + V                      G G
Sbjct: 1916 GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHV---------------------HGGG 1954

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
             P     P    V  G  V L CRA G+P  T+ W K+G +L            P +A  
Sbjct: 1955 GPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL------------PPQARS 2002

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
                   L I A    D+G Y+C A +  G AQA   + V    ++ P            
Sbjct: 2003 ERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASP-----------P 2051

Query: 247  PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
            P+K    +  V EG+     C V G    ++ W+  G  L P         +  G  L++
Sbjct: 2052 PVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-------HTQVHGSRLRL 2104

Query: 307  LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE---------PRLRFTRPLQDVEGREH-- 355
                  D G YVC   N +G   +++ + V           P    TRP++      H  
Sbjct: 2105 PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA 2164

Query: 356  --GIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE 413
                  L C VP        + +    LP R       G++ RL  H++   D G Y+C 
Sbjct: 2165 EGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQ---THGSLLRL--HQVTPADSGEYVCH 2219

Query: 414  MRGR--------VRTVANVTVKGPI--LKRLPRKLDVLEGENAVL-LVETLEAGVEGRWS 462
            + G         + T+    + GPI  ++       V EG+   L  V   +A  +  W 
Sbjct: 2220 VVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY 2279

Query: 463  RDGEELPV----------------------ICQSSSGHMHALVLPGVTREDAGEVTFSLG 500
            + G  LP                       +C++S+G M A +   VT      + +  G
Sbjct: 2280 KRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNG-MEASITVTVTGTQGANLAYPAG 2338

Query: 501  NSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYR-----LER 555
               +T  +R++      P    +AE      N V+    P +   +  +  R     +  
Sbjct: 2339 ---STQPIRIE------PSSSQVAEGQTLDLNCVV----PGQSHAQVTWHKRGGSLPVRH 2385

Query: 556  QEVGSEDWIQCFSIEKAGAVE----VPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAH 611
            Q  GS   ++ +    A + E    V G  VP E      + T+   G  P      +  
Sbjct: 2386 QTHGS--LLRLYQASPADSGEYVCRVLGSSVPLEASV---LVTIEPAGSVP------ALG 2434

Query: 612  LVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG------TWFLNGEELKSNEPEGQVEP 665
            + PT R+ +     QV +G+    +LDL+ ++ G      TW   G              
Sbjct: 2435 VTPTVRIES--SSSQVAEGQ----TLDLNCLVAGQAHAQVTWHKRG-------------- 2474

Query: 666  GALRYRIEQKGLQHRLILHAVKHQDSG----ALVGFSCPGVQDSAAL-TIQES------- 713
            G+L  R +  G + RL+   V   DSG     +VG S  G Q+++ L TIQ+        
Sbjct: 2475 GSLPARHQVHGSRLRLL--QVTPADSGEYVCRVVGSS--GTQEASVLVTIQQRLSGSHSQ 2530

Query: 714  ----PVHILSPQDRVSLTFTTSERVVLTCEL-SRVDFPATWYKDGQKVEESELLVVKMDG 768
                PV I S     S +      + L C + S+     TWYK G  +     +V     
Sbjct: 2531 GVAYPVRIESS----SASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV----- 2581

Query: 769  RKHRLILPEAKVQDSGEFECRTEGVS----AFFGVTVQ----------DPPVHIVDPREH 814
               RL +P+    DSGE+ C     +        VT+Q           PP+ I      
Sbjct: 2582 -GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT 2640

Query: 815  VFVHAITSECVMLACEVDRE-DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSD 873
            V    +  + + L C V R+  A + WYK G  +        +  G H R  L     +D
Sbjct: 2641 V----VEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH----QTHGSHLR--LHQMSVAD 2690

Query: 874  GGEFQCVAGDECAYFTVTIT-DVSSWIVYPSGKVYVAAVRL----------ERVVLTCEL 922
             GE+ C A +       +I   VS     PS       +R+          E + L C +
Sbjct: 2691 SGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVV 2750

Query: 923  -CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDES----A 977
              +  A+V W K G       +L    +    RL L  V   DSGEY+C +   S    A
Sbjct: 2751 PGQAHAQVTWHKRG------GSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEA 2804

Query: 978  SFTVTVT--------------EPPVRIIYPRDEVTL-IAVTLECVVLMCELSREDAPVRW 1022
            S  VT+                PP+RI      V     + L+CVV      +  A V W
Sbjct: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVV----PGQAHAQVTW 2860

Query: 1023 YKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTA------ 1076
            +K G  +     +     GP  R  L    P D GE+ C     S     +V        
Sbjct: 2861 HKRGGNLPARHQV----HGPLLR--LNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSS 2914

Query: 1077 ----PPERIVHPA-ARSLDLHFGAPGRVELRCEV-APAGSQVRWYKDGLEVEASDALQLG 1130
                P   +  P    +   H      ++L C V   A +QV WYK G  + A      G
Sbjct: 2915 PGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH-G 2973

Query: 1131 AEGPTRTLTLPHAQPEDAGEYVCETR-----HEAITFNVILAEPP-------VQFLALET 1178
            ++     L L    P D+GEYVC         +  +F V +  PP       ++   +  
Sbjct: 2974 SQ-----LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV--PPSEGSSYRLRSPVISI 3026

Query: 1179 TPSPLCVAPGEPVVLSCELSRAGAPV--VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAG 1236
             P    V  G+     C +    AP+   W    + +++     +H      ++ I    
Sbjct: 3027 DPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELED----NVHISPNGSIITIVGTR 3082

Query: 1237 PAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGP 1296
            P++ G Y C +  A G       + V  PP   V PE     V+      LE  V    P
Sbjct: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE-GPVWVKVGKAVTLE-CVSAGEP 3140

Query: 1297 GGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA--------PQDSR 1348
                RW +     A   +       +  VL++  A+  DAG Y+C A         Q   
Sbjct: 3141 RSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV 3200

Query: 1349 IFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEM 1407
            I       P   ++ +E   LTV  G  AT RC  +  P   + W +   + +P P    
Sbjct: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK---LRSPLPWQHR 3257

Query: 1408 AQNGSSRILTLRGCQLGDAG----TVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEG 1463
             + G + I+     Q  D+G      T  AG    +  LHV E+        +    + G
Sbjct: 3258 LE-GDTLIIPRVAQQ--DSGQYICNATSPAGHAEATIILHV-ESPPYATTVPEHASVQAG 3313

Query: 1464 QDV---CLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
            + V   CL   T  +      +W R G  LP     + A++  +H          D G Y
Sbjct: 3314 ETVQLQCLAHGTPPL----TFQWSRVGSSLP---GRATARNELLH---FERAAPEDSGRY 3363

Query: 1521 GCESHHD----RTLARLSVR--PRQL-------------RVLRPLEDVTISEGGSATFQL 1561
             C   +        A+L V+  P  L             +V   LE  T S G S  F  
Sbjct: 3364 RCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE--TKSIGASVEFHC 3421

Query: 1562 EL-SQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTA----DSL 1616
             + S  G    W + G QL PG   H   DG    L +  L  +  G     A       
Sbjct: 3422 AVPSDRGTQLRWFKEGGQLPPG---HSVQDG---VLRIQNLDQSCQGTYICQAHGPWGKA 3475

Query: 1617 RCAARLIVREVPVTIVRGPHDLE-VTEGDTATFEC-ELSQALADVTWEKDGNALTPSPRL 1674
            + +A+L+++ +P  ++     ++ V  G    FEC  L      VTW K G  L P    
Sbjct: 3476 QASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG--- 3532

Query: 1675 RLQALGTRRLLQLRRCGPSDAGTYSC----AVGTARAGPVRLTVRERTVAVLSELRSVSA 1730
             +Q+ G  R+  +     +DAG Y C    A GT ++  + L    + +  +S  + V  
Sbjct: 3533 IVQSGGVVRIAHVEL---ADAGQYRCTATNAAGTTQSHVLLLV---QALPQISMPQEVRV 3586

Query: 1731 REGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG 1786
              G  A F C  S   T    W      L P +R+      + ++L+L  +R +DAG
Sbjct: 3587 PAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL------ENNMLMLPSVRPQDAG 3637



 Score =  213 bits (542), Expect = 1e-54
 Identities = 502/2067 (24%), Positives = 749/2067 (36%), Gaps = 405/2067 (19%)

Query: 19   RPVRVVSGAEAELKCVVLGEPPP-VVVWEKGGQQLAASERLSFPADGAEHGLLLTAALP- 76
            R   V  GA+    C    + P   +VW +       +  + F      +G+L    +  
Sbjct: 1779 RSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDF------NGILTIRNVQL 1832

Query: 77   TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGE-GAPVFLTGPR 135
            +DAG YVC   N        A + V                     SG   APV    P 
Sbjct: 1833 SDAGTYVCTGSNMFAMDQGTATLHV-------------------QASGTLSAPVVSIHPP 1873

Query: 136  SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALR 195
               V  G      C A G P PTL W                   P +A+   G    LR
Sbjct: 1874 QLTVQPGQLAEFRCSATGSPTPTLEWT-----------GGPGGQLPAKAQIHGGI---LR 1919

Query: 196  ILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTF 255
            + A    D   Y+C A ++ G   A A+L VH               P V+    +P+  
Sbjct: 1920 LPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG-----------GGGPRVQ---VSPERT 1965

Query: 256  WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRG 315
             V+ G+  +  C   G P   I W  EG  L P  R     +R     L +      D G
Sbjct: 1966 QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARS----ERTDIATLLIPAITTADAG 2021

Query: 316  LYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAV-----LECKVPNS-RI 369
             Y+C A + AG   + +Q+ V         P++ +E     +       L C V  S   
Sbjct: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPVK-IESSSPSVTEGQTLDLNCVVAGSAHA 2080

Query: 370  PTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR-GRVRTVANVTVK- 427
               W+R    L P   + Q+      RL + ++   D G Y+C +  G     A++TV  
Sbjct: 2081 QVTWYRRGGSLPP---HTQVHGS---RLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134

Query: 428  ------GPILKRLP---RKLDVLEGENAVLLVETLE--------AGVEGRWSRDGEELPV 470
                  GP    +P   R + +    + V   +TL+        A  +  W + G  LP 
Sbjct: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194

Query: 471  ICQSSSGHMHALVLPGVTREDAGE----VTFSLGNSRTTTLLRVKCVKHSPPGPPILAEM 526
              Q+   H   L L  VT  D+GE    V  + G    + L+ ++      P PP+  E 
Sbjct: 2195 RHQT---HGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIES 2251

Query: 527  FKG---HKNTVLLTWKPPEPAPETPFIYR------LERQEVGSEDWIQCFSIEKAGAVEV 577
                     T+ L+      A      Y+         Q  GS  +I   S   AG    
Sbjct: 2252 SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYV- 2310

Query: 578  PGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSL 637
               C  S G       TV+G   +      GS     T  +       QV +G+    +L
Sbjct: 2311 ---CRASNGMEASITVTVTGTQGANLAYPAGS-----TQPIRIEPSSSQVAEGQ----TL 2358

Query: 638  DLSTIIQG------TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDS 691
            DL+ ++ G      TW   G              G+L  R +  G   RL  +     DS
Sbjct: 2359 DLNCVVPGQSHAQVTWHKRG--------------GSLPVRHQTHGSLLRL--YQASPADS 2402

Query: 692  GALV----GFSCPGVQDSAALTIQES---PVHILSPQDRV---SLTFTTSERVVLTCELS 741
            G  V    G S P ++ S  +TI+ +   P   ++P  R+   S      + + L C ++
Sbjct: 2403 GEYVCRVLGSSVP-LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVA 2461

Query: 742  -RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVS----AF 796
             +     TW+K G  +        ++ G + RL+  +    DSGE+ CR  G S    A 
Sbjct: 2462 GQAHAQVTWHKRGGSLPARH----QVHGSRLRLL--QVTPADSGEYVCRVVGSSGTQEAS 2515

Query: 797  FGVTVQDP-----------PVHIVDPREHVFV-HAITSECVMLACEVDREDAP--VRWYK 842
              VT+Q             PV I      +   H +   C++ +       AP  + WYK
Sbjct: 2516 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVAS------QAPHTITWYK 2569

Query: 843  DGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCV----AGDECAYFTVTITDV-SS 897
             G  +     +V        RL +P   P+D GE+ C     AG       VTI    SS
Sbjct: 2570 RGGSLPSRHQIV------GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 2623

Query: 898  WIVYPSGKVYVAA-----VRLERVVLTCELCR-PWAEVRWTKDGEEVVESPALLLQKEDT 951
             +   S  + + +     V  + + L C + R P A + W K G       +L  + +  
Sbjct: 2624 HVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGG------SLPSRHQTH 2677

Query: 952  VRRLVLPAVQLEDSGEYLCE----IDDESASFTVTVTEP-----------PVRIIYPRDE 996
               L L  + + DSGEY+C     ID   AS  ++V+             P+RI      
Sbjct: 2678 GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH 2737

Query: 997  VTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPED 1055
            V     + L CVV      +  A V W+K G       +L         RL L    P D
Sbjct: 2738 VAEGETLDLNCVVP----GQAHAQVTWHKRG------GSLPSHHQTRGSRLRLHHVSPAD 2787

Query: 1056 GGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPG-------------- 1097
             GE+VC     +G   A   VT+ A     VH  A       GAP               
Sbjct: 2788 SGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPG-----GAPPIRIEPSSSRVAEGQ 2842

Query: 1098 RVELRCEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR 1156
             ++L+C V   A +QV W+K G  + A   +     GP   L L    P D+GEY C+  
Sbjct: 2843 TLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH----GPL--LRLNQVSPADSGEYSCQVT 2896

Query: 1157 HEAITFN---VILAEP------PVQFLA--LETTPSPLCVAPGEPVVLSCEL-SRAGAPV 1204
              + T     ++  EP      P   LA  +    S   V  G+ + L+C +  +A A V
Sbjct: 2897 GSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV 2956

Query: 1205 VWSHNG-----RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPS-LSF 1258
             W   G     R    G  L LH              PA +G Y C++ + PG     SF
Sbjct: 2957 TWYKRGGSLPARHQTHGSQLRLHL-----------VSPADSGEYVCRAASGPGPEQEASF 3005

Query: 1259 TVQVAEPPVR---------VVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERL 1309
            TV V  PP           V++ +   + V+       + ++H       + W    + L
Sbjct: 3006 TVTV--PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL 3063

Query: 1310 ASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQD----SRIFLVSVEEPLLVKLVSE 1365
              +  V +   G+  ++ + G R  + G Y C A         +  +SV  P  V ++ E
Sbjct: 3064 --EDNVHISPNGS--IITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE 3119

Query: 1366 LTPLTVHEGDDATFRC-EVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
              P+ V  G   T  C     P +   W R  +      Q       S  +L +   +  
Sbjct: 3120 -GPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPS 3178

Query: 1425 DAGTVTLRAGSTATSARLHVR---ETELLFLRRLQDVRAEEGQDVCLEVETG-----RVG 1476
            DAGT    A +   +A+  V    +T  +     Q V+AEE +   L VE G     R  
Sbjct: 3179 DAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQ-VQAEEAE---LTVEAGHTATLRCS 3234

Query: 1477 AAGA----VRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLAR 1532
            A G+    + W +   PLP   RL          L I  V   D G Y C +      A 
Sbjct: 3235 ATGSPAPTIHWSKLRSPLPWQHRLEG------DTLIIPRVAQQDSGQYICNATSPAGHAE 3288

Query: 1533 LSVRPRQLRVLRPLEDVTISEGGSA----TFQLELSQEG---VTGEWARGGVQLYPGPKC 1585
             ++    L V  P    T+ E  S     T QL+    G   +T +W+R G  L PG   
Sbjct: 3289 ATII---LHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-PG--- 3341

Query: 1586 HIHSDGHRHRLVLNGLGLADSG---C-VSFTADSLRCAARLIVREVPVTI---------- 1631
               +      L        DSG   C V+    S    A+L+V+  P ++          
Sbjct: 3342 --RATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGST 3399

Query: 1632 --VRGPHDLEVTE-GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQL 1687
              V+    LE    G +  F C + S     + W K+G  L P   ++        +L++
Sbjct: 3400 PTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ------DGVLRI 3453

Query: 1688 RRCGPSDAGTYSCAV----GTARAGPVRLTVRERTVAVLSELRSV-SAREGDGATFEC-T 1741
            +    S  GTY C      G A+A   +L ++     +++   SV +   G    FEC  
Sbjct: 3454 QNLDQSCQGTYICQAHGPWGKAQAS-AQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA 3512

Query: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQS 1797
            + + +    W   G  LRPG    I Q G   ++ ++ +   DAG+ R  A    G  QS
Sbjct: 3513 LGDPKPQVTWSKVGGHLRPG----IVQSGG--VVRIAHVELADAGQYRCTATNAAGTTQS 3566

Query: 1798 LALLEVEALP-LQMCRHPPREKTVLVGRRAVLEVTVSR-SGGHVCWLREGAELCPGDKYE 1855
              LL V+ALP + M    P+E  V  G  AV     S      + W +    L P  + E
Sbjct: 3567 HVLLLVQALPQISM----PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE 3622

Query: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
                   + L++  VRP+D GTY C A
Sbjct: 3623 ------NNMLMLPSVRPQDAGTYVCTA 3643



 Score =  187 bits (476), Expect = 6e-47
 Identities = 450/1967 (22%), Positives = 693/1967 (35%), Gaps = 373/1967 (18%)

Query: 121  PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEK-DGMALDEVWDSSHFAL 179
            P + +   V    P    V +G    L C+  G P    YW + DG  +       H   
Sbjct: 1670 PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS 1729

Query: 180  QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP-PADPD 238
            +             L   + +  D+GVY+C  RN H    + A L V + P  P     +
Sbjct: 1730 E-------------LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVE 1776

Query: 239  EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGK-PEPEIEWHWEGRPLLPDRRRLMYRD 297
            E  +  V P            G    F C    K P   + W       LP R       
Sbjct: 1777 EQRSQSVRP------------GADVTFICTAKSKSPAYTLVWTRLHNGKLPTRA------ 1818

Query: 298  RDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK------EPRLRFTRPLQDVE 351
             D   +L +   Q  D G YVC   N          LHV+       P +    P   V+
Sbjct: 1819 MDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQ 1878

Query: 352  GREHGIAVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY 410
              +  +A   C    S  PT  W       LP +   QI  G +R   +  ++  D   Y
Sbjct: 1879 PGQ--LAEFRCSATGSPTPTLEWTGGPGGQLPAK--AQIHGGILR---LPAVEPTDQAQY 1931

Query: 411  LCEMRGRV-RTVANVTVK-----GPILKRLPRKLDVLEGENAVLLVETLEAGVEG---RW 461
            LC       + VA   +      GP ++  P +  V  G    L      AGV      W
Sbjct: 1932 LCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRA--AGVPSATITW 1989

Query: 462  SRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPP 521
             ++G  LP   +S    +  L++P +T  DAG   F L            CV  SP G  
Sbjct: 1990 RKEGGSLPPQARSERTDIATLLIPAITTADAG---FYL------------CVATSPAGTA 2034

Query: 522  ILAEMFKGHKNTVLLTWKPPEPAP-----ETPFIYRLERQE----VGSEDWIQCFSIEKA 572
                  +     V+L+     P P      +P +   +  +    V      Q     + 
Sbjct: 2035 ------QARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRG 2088

Query: 573  GA-----------VEVPGDCVPSEGDYRFRICTVSGHGRSPHV--VFHGSAHLVPTARLV 619
            G+           + +P       G+Y  R+   SG   +     V HG+ H  P+   V
Sbjct: 2089 GSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGT-HSGPSYTPV 2147

Query: 620  AG-LEDVQVYDGEDAVF---SLDLSTIIQG------TWFLNGEELKSNEPEGQVEPGALR 669
             G    +++      V    +LDL+ ++ G      TW   G              G+L 
Sbjct: 2148 PGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRG--------------GSLP 2193

Query: 670  YRIEQKGLQHRLILHAVKHQDSGA----LVGFSCPGVQDSAALTIQESPVHILSPQDRV- 724
             R +  G    L LH V   DSG     +VG S P ++ S  +TI+ S +    P  R+ 
Sbjct: 2194 ARHQTHG--SLLRLHQVTPADSGEYVCHVVGTSGP-LEASVLVTIEASVIPGPIPPVRIE 2250

Query: 725  --SLTFTTSERVVLTCELS-RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ 781
              S T    + + L+C ++ +     TWYK G        L  +   R  RL + +A   
Sbjct: 2251 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS------LPARHQVRGSRLYIFQASPA 2304

Query: 782  DSGEFECR-TEGVSAFFGVTV-------------QDPPVHIVDPREHVFVHAITSECVML 827
            D+G++ CR + G+ A   VTV                P+ I      V       + + L
Sbjct: 2305 DAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQV----AEGQTLDL 2360

Query: 828  ACEV-DREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC-VAGDEC 885
             C V  +  A V W+K G  +       + ++     L L    P+D GE+ C V G   
Sbjct: 2361 NCVVPGQSHAQVTWHKRGGSLP------VRHQTHGSLLRLYQASPADSGEYVCRVLGSSV 2414

Query: 886  ---AYFTVTIT---DVSSWIVYPSGKVYVAAVRL---ERVVLTCELC-RPWAEVRWTKDG 935
               A   VTI     V +  V P+ ++  ++ ++   + + L C +  +  A+V W K G
Sbjct: 2415 PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474

Query: 936  EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI----DDESASFTVTVTEP----- 986
                   +L  + +    RL L  V   DSGEY+C +      + AS  VT+ +      
Sbjct: 2475 ------GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSH 2528

Query: 987  ------PVRIIYPRDEVTLI---AVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVL 1037
                  PVRI       +L     + L C+V     S+    + WYK G  +     +V 
Sbjct: 2529 SQGVAYPVRI--ESSSASLANGHTLDLNCLV----ASQAPHTITWYKRGGSLPSRHQIV- 2581

Query: 1038 ERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHF 1093
                   RL +P   P D GE+VC     AG       VT+       V   +  + +  
Sbjct: 2582 -----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES 2636

Query: 1094 GAPGRVE-----LRCEVA-PAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPED 1147
             +P  VE     L C VA    + + WYK G       +L    +     L L      D
Sbjct: 2637 SSPTVVEGQTLDLNCVVARQPQAIITWYKRG------GSLPSRHQTHGSHLRLHQMSVAD 2690

Query: 1148 AGEYVCETRH--EAITFNVILA--------EPPVQFLALETTPSPLCVAPGEPVVLSCEL 1197
            +GEYVC   +  +A+  +++++          P   + +    S   VA GE + L+C +
Sbjct: 2691 SGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVV 2750

Query: 1198 -SRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSL 1256
              +A A V W       + G  L  H +     L +    PA +G Y C+   + G    
Sbjct: 2751 PGQAHAQVTWH------KRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEA 2804

Query: 1257 SFTVQV--------------AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG---GP 1299
            S  V +                PP+R+   E + +RV      DL+ VV    PG     
Sbjct: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRI---EPSSSRVAEGQTLDLKCVV----PGQAHAQ 2857

Query: 1300 VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIF----LVSVE 1355
            V W+K G  L ++ +V         +LR+      D+GEY C     S       LV++E
Sbjct: 2858 VTWHKRGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE 2911

Query: 1356 EP---------LLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQV 1405
                       L   +  E +   V EG      C V     A VTW + G  +    Q 
Sbjct: 2912 PSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQT 2971

Query: 1406 EMAQNGSSRILTLRGCQLGDAGTVTLRAGS-----TATSARLHVRETELLFLRRLQDV-- 1458
              +Q      L L      D+G    RA S        S  + V  +E    R    V  
Sbjct: 2972 HGSQ------LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025

Query: 1459 ------RAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGV 1512
                    ++GQD   +       A  ++ W    Q L  +  + ++ +G I  + I G 
Sbjct: 3026 IDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNGSI--ITIVGT 3081

Query: 1513 ILADQGTYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ-LELSQEG 1567
              ++ GTY C + +     +++  LSV       + P   V +  G + T + +   +  
Sbjct: 3082 RPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPR 3141

Query: 1568 VTGEWAR-GGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVRE 1626
             +  W R          + +   D H   L ++    +D+G     A +    A+  V  
Sbjct: 3142 SSARWTRISSTPAKLEQRTYGLMDSHA-VLQISSAKPSDAGTYVCLAQNALGTAQKQVEV 3200

Query: 1627 VPVTIVRGP---------HDLEVTEGDTATFECELSQALA-DVTWEKDGNALTPSPRLRL 1676
            +  T    P          +L V  G TAT  C  + + A  + W K  + L    RL  
Sbjct: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260

Query: 1677 QALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTV---RERTVAVLSELRSVSAREG 1733
              L   R+ Q       D+G Y C   T+ AG    T+    E      +     S + G
Sbjct: 3261 DTLIIPRVAQ------QDSGQYICN-ATSPAGHAEATIILHVESPPYATTVPEHASVQAG 3313

Query: 1734 DGATFECTV-SEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA 1792
            +    +C        T +W   G  L PG     R   +  +L       ED+G  R + 
Sbjct: 3314 ETVQLQCLAHGTPPLTFQWSRVGSSL-PG-----RATARNELLHFERAAPEDSGRYRCRV 3367

Query: 1793 ----------------GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRS 1835
                            GP  SL    + A      +  P+ +T  +G        V S  
Sbjct: 3368 TNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDR 3427

Query: 1836 GGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
            G  + W +EG +L PG   +         L I ++    QGTY CQA
Sbjct: 3428 GTQLRWFKEGGQLPPGHSVQ------DGVLRIQNLDQSCQGTYICQA 3468



 Score =  122 bits (305), Expect = 4e-27
 Identities = 270/1150 (23%), Positives = 406/1150 (35%), Gaps = 192/1150 (16%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG- 68
            SPP  +    P  VV G   +L CVV  +P  ++ W K G  L        P+    HG 
Sbjct: 2629 SPPIRIESSSPT-VVEGQTLDLNCVVARQPQAIITWYKRGGSL--------PSRHQTHGS 2679

Query: 69   -LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
             L L      D+G YVCRA N   +A  A+ V  + P A  P    +  P+    S    
Sbjct: 2680 HLRLHQMSVADSGEYVCRANNNI-DALEASIVISVSPSAGSPSAPGSSMPIRIESS---- 2734

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
                    S  V  G  + L C   G     + W K G +L      SH   +  R    
Sbjct: 2735 --------SSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLP-----SHHQTRGSR---- 2777

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
                  LR+      DSG YVC    + G  +A  L+ +     S    P    AP   P
Sbjct: 2778 ------LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP---P 2828

Query: 248  LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
            ++  P +  V EG+    +C V G+   ++ WH  G  L P R ++       G +L++ 
Sbjct: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQVH------GPLLRLN 2881

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKE------PRLRFTRPLQDVEGREH----GI 357
                 D G Y C    S+G   ++V + ++       P     +P+       H      
Sbjct: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941

Query: 358  AVLECKVPN-SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRG 416
              L C VP  +     W++    L P R      +     L +H +   D G Y+C    
Sbjct: 2942 LDLNCVVPGQAHAQVTWYKRGGSL-PARHQTHGSQ-----LRLHLVSPADSGEYVCRAAS 2995

Query: 417  ----RVRTVANVTV----------KGPILKRLPRKLDVLEGENAVL--LVETLEAGVEGR 460
                       VTV          + P++   P    V +G++A    L+    A +   
Sbjct: 2996 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 3055

Query: 461  WSRDGEELPV-ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
            W    +EL   +  S +G +  +V  G    + G       N+       V    H PP 
Sbjct: 3056 WKTRNQELEDNVHISPNGSIITIV--GTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPT 3113

Query: 520  PPILAE---MFKGHKNTVLLTWKPPEPAPETPFIY------RLERQEVGSEDWIQCFSIE 570
              +L E     K  K   L      EP     +        +LE++  G  D      I 
Sbjct: 3114 VSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQIS 3173

Query: 571  KAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDG 630
             A     P D     G Y        G  +    V      +V T  +  G   VQ  + 
Sbjct: 3174 SAK----PSDA----GTYVCLAQNALGTAQKQVEV------IVDTGAMAPGAPQVQAEEA 3219

Query: 631  EDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRL-----ILHA 685
            E  V +   +T+             +  P   +    LR  +     QHRL     I+  
Sbjct: 3220 ELTVEAGHTATLRCSA---------TGSPAPTIHWSKLRSPLPW---QHRLEGDTLIIPR 3267

Query: 686  VKHQDSGALV--GFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV 743
            V  QDSG  +    S  G  ++  +   ESP +  +  +  S+     E V L C L+  
Sbjct: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQ--AGETVQLQC-LAHG 3324

Query: 744  DFPAT--WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG----VSAFF 797
              P T  W + G        L  +   R   L    A  +DSG + CR         AF 
Sbjct: 3325 TPPLTFQWSRVGSS------LPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFA 3378

Query: 798  GVTVQDPPVHIV--------DPREHVFVHAITSEC---VMLACEVDRE-DAPVRWYKDGQ 845
             + VQ PP  +          P   V     T      V   C V  +    +RW+K+G 
Sbjct: 3379 QLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGG 3438

Query: 846  EVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWIVY 901
            ++     V    +G  R   +     S  G + C A    G   A   + I  + S ++ 
Sbjct: 3439 QLPPGHSV---QDGVLR---IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLIN 3492

Query: 902  PSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQ 961
                V    V          L  P  +V W+K G  +      ++Q    VR   +  V+
Sbjct: 3493 IRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG---IVQSGGVVR---IAHVE 3546

Query: 962  LEDSGEYLCEIDDESA---SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDA 1018
            L D+G+Y C   + +    S  + + +   +I  P+ EV + A +    V  C  S    
Sbjct: 3547 LADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ-EVRVPAGS--AAVFPCIASGYPT 3603

Query: 1019 P-VRWYK-DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTV 1072
            P + W K DG    +S    LE +     L+LP+ +P+D G +VC A    G   AF  +
Sbjct: 3604 PDISWSKLDGSLPPDSR---LENN----MLMLPSVRPQDAGTYVCTATNRQGKVKAFAHL 3656

Query: 1073 TVTAPPERIV 1082
             V   PER+V
Sbjct: 3657 QV---PERVV 3663



 Score =  117 bits (293), Expect = 1e-25
 Identities = 138/501 (27%), Positives = 190/501 (37%), Gaps = 89/501 (17%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEK--------GGQQLAASERLSFPADGAEHGLLLTAA 74
            V  G    L+C V G PP    W +        G QQ      L FP+            
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPS-----------V 1736

Query: 75   LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
             P+DAGVY+C  RN      + A + V E P+         +P+          V +   
Sbjct: 1737 QPSDAGVYICTCRNLHQSNTSRAELLVTEAPS---------KPI---------TVTVEEQ 1778

Query: 135  RSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLAL 194
            RSQ V  GA+V   C A          +    A   VW   H    P RA D  G    L
Sbjct: 1779 RSQSVRPGADVTFICTA----------KSKSPAYTLVWTRLHNGKLPTRAMDFNG---IL 1825

Query: 195  RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKT 254
             I   +L D+G YVC   N     Q  A L V               APVV      P  
Sbjct: 1826 TIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA--------SGTLSAPVV---SIHPPQ 1874

Query: 255  FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
              V  G+ A+FRC   G P P +EW       LP + ++       G +L++   +  D+
Sbjct: 1875 LTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQI------HGGILRLPAVEPTDQ 1928

Query: 315  GLYVCAARNSAGQTLSAVQLHVK---EPRLRFTRPLQDVE-GREHGIAVLECKVPNSRIP 370
              Y+C A +SAGQ ++   LHV     PR++ +     V  GR   +      VP++ I 
Sbjct: 1929 AQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI- 1987

Query: 371  TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---------EMRGRVRTV 421
              W +E   L P  + E+ +  T   L+I  +   D G YLC         + R +V  +
Sbjct: 1988 -TWRKEGGSLPPQARSERTDIAT---LLIPAITTADAGFYLCVATSPAGTAQARIQVVVL 2043

Query: 422  ANVTVKGPILKRLPRKLDVLEGENAVL-LVETLEAGVEGRWSRDGEELPVICQSSSGHMH 480
            +      P +K       V EG+   L  V    A  +  W R G  LP   Q    H  
Sbjct: 2044 SASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV---HGS 2100

Query: 481  ALVLPGVTREDAGEVTFSLGN 501
             L LP V+  D+GE    + N
Sbjct: 2101 RLRLPQVSPADSGEYVCRVEN 2121



 Score =  117 bits (293), Expect = 1e-25
 Identities = 318/1298 (24%), Positives = 468/1298 (36%), Gaps = 241/1298 (18%)

Query: 748  TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG----------VSAFF 797
            TWY+ G  +     +         RL LP+    DSGE+ CR E           VS   
Sbjct: 2083 TWYRRGGSLPPHTQV------HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLH 2136

Query: 798  G---------VTVQDPPVHIVDPREHVFVHAITSECVMLACEVDRE-DAPVRWYKDGQEV 847
            G         V     P+ I     HV       + + L C V  +  A V W+K G  +
Sbjct: 2137 GTHSGPSYTPVPGSTRPIRIEPSSSHV----AEGQTLDLNCVVPGQAHAQVTWHKRGGSL 2192

Query: 848  EESDFVVLENEGPHRRLVLPATQPSDGGEFQC--VAGDECAYFTVTITDVSSWIVYPSGK 905
                     ++     L L    P+D GE+ C  V        +V +T  +S I  P   
Sbjct: 2193 PA------RHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPP 2246

Query: 906  VYVAA-----VRLERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPA 959
            V + +        + + L+C +  +  A+V W K G  +   PA   + +    RL +  
Sbjct: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL---PA---RHQVRGSRLYIFQ 2300

Query: 960  VQLEDSGEYLCEIDDE-SASFTVTVTEPP-VRIIYPRDEVTLIAVT-------------L 1004
                D+G+Y+C   +   AS TVTVT      + YP      I +              L
Sbjct: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDL 2360

Query: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
             CVV      +  A V W+K G       +L +        L L  A P D GE+VC   
Sbjct: 2361 NCVVP----GQSHAQVTWHKRG------GSLPVRHQTHGSLLRLYQASPADSGEYVCRVL 2410

Query: 1065 DDS----AFFTVTVT---APPERIVHPAAR--SLDLHFGAPGRVELRCEVA-PAGSQVRW 1114
              S    A   VT+    + P   V P  R  S          ++L C VA  A +QV W
Sbjct: 2411 GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470

Query: 1115 YKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCET-----RHEA---ITFNVIL 1166
            +K G  + A   +          L L    P D+GEYVC         EA   +T    L
Sbjct: 2471 HKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRL 2524

Query: 1167 AEPPVQFLA--LETTPSPLCVAPGEPVVLSCEL-SRAGAPVVWSHNGRPVQEGEGLELHA 1223
            +    Q +A  +    S   +A G  + L+C + S+A   + W   G  +     +    
Sbjct: 2525 SGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV--- 2581

Query: 1224 EGPRRVLCIQAAGPAHAGLYTCQ--SGAAPGAPSLSFTVQVA--------EPPVRVVAPE 1273
             G R  L I    PA +G Y C   +GA     SL  T+Q +         PP+R+   E
Sbjct: 2582 -GSR--LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRI---E 2635

Query: 1274 AAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARS 1333
            ++   V      DL  VV    P   + WYK G  L S+ +           LR+     
Sbjct: 2636 SSSPTVVEGQTLDLNCVVARQ-PQAIITWYKRGGSLPSRHQTHGSH------LRLHQMSV 2688

Query: 1334 GDAGEYLC------DAPQDSRIFLVSVEEPL------LVKLVSELTPLTVHEGDDATFRC 1381
             D+GEY+C      DA + S +  VS            + +  E +   V EG+     C
Sbjct: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2748

Query: 1382 EV-SPPDADVTWLRNGAVVTPGPQ----------VEMAQNGS--SRILTLRGCQLGDAGT 1428
             V     A VTW + G  +    Q          V  A +G    R++   G  L  +  
Sbjct: 2749 VVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG-PLEASVL 2807

Query: 1429 VTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGA-VRWVRGG 1487
            VT+ A     S+ +HV         R++   +   +   L+++    G A A V W + G
Sbjct: 2808 VTIEASG---SSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRG 2864

Query: 1488 QPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLE 1547
              LP   ++      H   L ++ V  AD G Y C+          SV    L  + P  
Sbjct: 2865 GNLPARHQV------HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASV----LVTIEPSS 2914

Query: 1548 DVTISEGGSAT-FQLELSQEGVT------------GEWARGGVQLYP-GPKCHIHSDGHR 1593
               I   G A    +E S   VT            G+ A   V  Y  G         H 
Sbjct: 2915 PGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQ-AHAQVTWYKRGGSLPARHQTHG 2973

Query: 1594 HRLVLNGLGLADSG---CVSFTADSLRCAARLIVREVPV----------TIVRGPHDLEV 1640
             +L L+ +  ADSG   C + +       A   V   P            I   P    V
Sbjct: 2974 SQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTV 3033

Query: 1641 TEGDTATFECELSQALADVTWE--------KDGNALTPSPRLRLQALGTRRLLQLRRCGP 1692
             +G  A+F+C +    A ++ E        +D   ++P+  + +  +GTR         P
Sbjct: 3034 QQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSI-ITIVGTR---------P 3083

Query: 1693 SDAGTYSCAVGTARA---GPVRLTVR-ERTVAVLSELRSVSAREGDGATFEC-TVSEVET 1747
            S+ GTY C    A       V L+V    TV+VL E   V  + G   T EC +  E  +
Sbjct: 3084 SNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE-GPVWVKVGKAVTLECVSAGEPRS 3142

Query: 1748 TGRWELGGRPLRPGARVRIRQEG---KKHILVLSELRAEDAGEVRFQAGPAQSLALLEVE 1804
            + RW    R     A++  R  G      +L +S  +  DAG     A  A   A  +VE
Sbjct: 3143 SARWT---RISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVE 3199

Query: 1805 ALPLQMCRHP--------PREKTVLVGRRAVLEVTVSRSGGH-VCWLREGAELCPGDKYE 1855
             +       P          E TV  G  A L  + + S    + W +  + L     ++
Sbjct: 3200 VIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL----PWQ 3255

Query: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
             R  G T  L+I  V  +D G Y C A   + H    +
Sbjct: 3256 HRLEGDT--LIIPRVAQQDSGQYICNATSPAGHAEATI 3291



 Score =  117 bits (292), Expect = 1e-25
 Identities = 215/913 (23%), Positives = 330/913 (36%), Gaps = 134/913 (14%)

Query: 9    GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
            G+PP  +  P   RV  G   +LKCVV G+    V W K G  L A  ++  P       
Sbjct: 2825 GAPPIRIE-PSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL------ 2877

Query: 69   LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
            L L    P D+G Y C+   ++G   A+  VT+ EP  S P       P+P+PG  +  P
Sbjct: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI-EP--SSP------GPIPAPGLAQ--P 2926

Query: 129  VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
            +++    S  V  G  + L C   G     + W K G +L            P R +   
Sbjct: 2927 IYIEASSSH-VTEGQTLDLNCVVPGQAHAQVTWYKRGGSL------------PARHQT-H 2972

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
            G+ L L +++    DSG YVC A +  G  Q  A   V  PP    +    +P   ++  
Sbjct: 2973 GSQLRLHLVSP--ADSGEYVCRAASGPGPEQE-ASFTVTVPPSEGSSYRLRSPVISID-- 3027

Query: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEP-EIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
               P +  V +G+ A F+C +     P  +EW    + L  +           G ++ ++
Sbjct: 3028 ---PPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN-----VHISPNGSIITIV 3079

Query: 308  YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLEC-KVPN 366
              +  + G Y C A N+ G   S V L V  P      P   V  +      LEC     
Sbjct: 3080 GTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGE 3139

Query: 367  SRIPTAWFR--EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT---- 420
             R    W R       L  R Y  ++   V  L I   K  D G Y+C  +  + T    
Sbjct: 3140 PRSSARWTRISSTPAKLEQRTYGLMDSHAV--LQISSAKPSDAGTYVCLAQNALGTAQKQ 3197

Query: 421  VANVTVKGPILKRLPRKLDVLEGENAVLLVE-----TLEAGVEG------RWSRDGEELP 469
            V  +   G +    P+    ++ E A L VE     TL     G       WS+    LP
Sbjct: 3198 VEVIVDTGAMAPGAPQ----VQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLP 3253

Query: 470  VICQSSSGHMHALVLPGVTREDAGE----VTFSLGNSRTTTLLRVKCVKHSPPGPPILAE 525
               +        L++P V ++D+G+     T   G++  T +L V+    SPP    + E
Sbjct: 3254 WQHRLEG---DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVE----SPPYATTVPE 3306

Query: 526  MFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSE 585
                     +         P   F    +   VGS   +   +  +   +          
Sbjct: 3307 HASVQAGETVQLQCLAHGTPPLTF----QWSRVGSS--LPGRATARNELLHFERAAPEDS 3360

Query: 586  GDYRFRICTVSGHGRS-PHVVFHGSAHLVPTARLVAG----------LEDVQVYDGEDAV 634
            G YR R+    G   +   ++  G    +P   + AG          LE   +    +  
Sbjct: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420

Query: 635  FSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGAL 694
             ++      Q  WF  G +L    P   V+ G LR +   +  Q   I  A  H   G  
Sbjct: 3421 CAVPSDRGTQLRWFKEGGQL---PPGHSVQDGVLRIQNLDQSCQGTYICQA--HGPWGK- 3474

Query: 695  VGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTC-ELSRVDFPATWYKDG 753
                    Q SA L IQ  P  +++ +  V  T      V   C  L       TW K G
Sbjct: 3475 -------AQASAQLVIQALPSVLINIRTSVQ-TVVVGHAVEFECLALGDPKPQVTWSKVG 3526

Query: 754  QKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC---RTEGVSAFFGVTVQDPPVHIVD 810
              +      +V+  G    + +   ++ D+G++ C      G +    + +      I  
Sbjct: 3527 GHLRPG---IVQSGG---VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISM 3580

Query: 811  PREHVFVHAITSECVMLACEVDREDAP-VRWYK-DGQEVEESDFVVLENEGPHRRLVLPA 868
            P+E   V        +  C       P + W K DG    +S    LEN      L+LP+
Sbjct: 3581 PQE---VRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR---LEN----NMLMLPS 3630

Query: 869  TQPSDGGEFQCVA 881
             +P D G + C A
Sbjct: 3631 VRPQDAGTYVCTA 3643



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 92/341 (26%), Positives = 124/341 (36%), Gaps = 72/341 (21%)

Query: 1    MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 60
            + A+S   GS P     P+      GA  E  C V  +    + W K G QL        
Sbjct: 3389 LPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP------- 3441

Query: 61   PADGAEHGLLLTAALPTDA-GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
            P    + G+L    L     G Y+C+A    G+A A+A + +                  
Sbjct: 3442 PGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI------------------ 3483

Query: 120  SPGSGEGAPVFLTGPRS--QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHF 177
                 +  P  L   R+  Q V+ G  V   C A G P+P + W K G          H 
Sbjct: 3484 -----QALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVG---------GH- 3528

Query: 178  ALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADP 237
             L+PG  + G      +RI    L D+G Y C A NA G  Q+  LL V   P+   + P
Sbjct: 3529 -LRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI--SMP 3581

Query: 238  DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRD 297
             E   P                G  A F C   G P P+I W      L PD R      
Sbjct: 3582 QEVRVPA---------------GSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL----- 3621

Query: 298  RDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
                 +L +   + +D G YVC A N  G+  +   L V E
Sbjct: 3622 --ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 28/110 (25%), Positives = 44/110 (40%), Gaps = 9/110 (8%)

Query: 11  PPCFLRFPRP-VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
           PP  +  PR  ++   G      CV +G P P++ W      + +  R++  ++G    L
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464

Query: 70  LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
           ++     +D G Y C A NA G  +          P    EL P   P P
Sbjct: 465 IIRDVKESDQGAYTCEAMNARGMVFGI--------PDGVLELVPQRGPCP 506



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 35/113 (30%), Positives = 43/113 (38%), Gaps = 10/113 (8%)

Query: 105 PASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQWVLRGAEVVLTCRAGGLPEPTLYWEK 163
           PAS    + ++ P  S   G   P  +T PR S    RG  V  TC A G+P P + W  
Sbjct: 383 PASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRL 442

Query: 164 DGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHG 216
           +       W   H    P       G    L I   +  D G Y C A NA G
Sbjct: 443 N-------W--GHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 2/82 (2%)

Query: 1627 VPVTIVRGPHD-LEVTEGDTATFEC-ELSQALADVTWEKDGNALTPSPRLRLQALGTRRL 1684
            +P  +V  P + ++ + G T TF C  +      + W  +   +   PR+ + + G R  
Sbjct: 404  MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463

Query: 1685 LQLRRCGPSDAGTYSCAVGTAR 1706
            L +R    SD G Y+C    AR
Sbjct: 464  LIIRDVKESDQGAYTCEAMNAR 485



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 8/88 (9%)

Query: 241 PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEW--HWEGRPLLPDRRRLMYRDR 298
           P  VV P +   ++   + G+   F C  +G P P I W  +W     +P   R+     
Sbjct: 405 PPQVVTPPR---ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGH---IPSHPRVTVTSE 458

Query: 299 DGGFVLKVLYCQAKDRGLYVCAARNSAG 326
            G   L +   +  D+G Y C A N+ G
Sbjct: 459 GGRGTLIIRDVKESDQGAYTCEAMNARG 486


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score =  164 bits (416), Expect = 6e-40
 Identities = 217/869 (24%), Positives = 334/869 (38%), Gaps = 131/869 (15%)

Query: 21   VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
            V V  GA+  LKC++   PPP V W K G  L +  RL   A+G  H LLL  A   DAG
Sbjct: 731  VVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAG 790

Query: 81   VYVCRARNAAGEAYAAAAVTV-------------------LEPPASDPE------LQPAE 115
             Y+  A N  G+A  AA++TV                   L PP   PE        P  
Sbjct: 791  SYMATATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTM 850

Query: 116  RPLPSPG------SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALD 169
            +P PS          +  P F      Q V  G +V+++ R  G P+P + W ++   + 
Sbjct: 851  KPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVR 910

Query: 170  EVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQP 229
               D   F      AE+  G    LRILAA   D+G Y C A N +G  Q  A L+V   
Sbjct: 911  P--DQRRF------AEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAH 962

Query: 230  PESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPD 289
            PES           V+ PL+       V  G+ A F C V G  + E++W   GR L P 
Sbjct: 963  PES-------RSLAVLAPLQDVD----VGAGEMALFECLVAGPTDVEVDWLCRGRLLQPA 1011

Query: 290  RRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLR--FTRPL 347
              +           L +      D G+Y C    +  +   + +L V+ P L   FTR L
Sbjct: 1012 LLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVR-PSLAPLFTRLL 1070

Query: 348  QDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADD 406
            +DVE  E   A  +CK+  +  P   W      +         ++G +  L I  + ++D
Sbjct: 1071 EDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSED 1130

Query: 407  DGIY---LCEMRGRVRTVANVTVKGP---------ILKRLPR--------KLDVLEGENA 446
            +G+Y        G+    A + V+ P          L+++P         +L+ L   + 
Sbjct: 1131 EGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEQGELERLSIPDF 1190

Query: 447  VLLVETLEAGVEGRWSRD----GEELPVICQSSSGH---------------MHALVLPGV 487
            +  ++ LE G+      +    G   P I    +GH               +H LV P V
Sbjct: 1191 LRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAV 1250

Query: 488  TREDAGEVTFSLGNSRTTTLLRVKCVKH-----SPPGPPILA-EMFKGHKNTVLLTWKPP 541
              + AG     + N     L +  C  H       PGPP  A ++       V LTW PP
Sbjct: 1251 GPQHAGVYKSVIANK----LGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPP 1306

Query: 542  EPA-----PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVS 596
                    P++   Y ++ Q +GS+ W    +  +       G     +  +R    TV 
Sbjct: 1307 RSLDMAIDPDS-LTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLSTTVK 1365

Query: 597  GHGR-SP-----HVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFL 649
               + SP      ++ HG   L     ++   + V V +G+ A  ++  + +  Q  W  
Sbjct: 1366 SSSKPSPPSEPVQLLEHGPT-LEEAPAMLDKPDIVYVVEGQPASVTVTFNHVEAQVVWRS 1424

Query: 650  NGEELKSNEPEGQVEPGALRYRIEQ-KGLQHRLILHAVKHQDSGAL--VGFSCPGVQD-S 705
                L        +E  A  Y + Q    Q+ L +  V  +D GAL     +  G Q  S
Sbjct: 1425 CRGAL--------LEARAGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCS 1476

Query: 706  AALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVK 765
              L + E+P    S  + V +    + R  +  E   +     WYKD   + ES  +   
Sbjct: 1477 VTLELAEAP-RFESIMEDVEVGAGETARFAVVVEGKPLP-DIMWYKDEVLLTESSHVSFV 1534

Query: 766  MDGRKHRLILPEAKVQDSGEFECRTEGVS 794
             +  +  L++     QD G + C  + ++
Sbjct: 1535 YEENECSLVVLSTGAQDGGVYTCTAQNLA 1563



 Score =  135 bits (340), Expect = 4e-31
 Identities = 141/477 (29%), Positives = 200/477 (41%), Gaps = 64/477 (13%)

Query: 1249 AAPGAPSLSFT----VQVAEPPVRVVAPEAAQTRVRSTPGGDLEL-VVHLSGPGGPVRWY 1303
            A P +P L  +    V   E P+     E     V   PG D+ L  +  + P   V W+
Sbjct: 697  ARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWH 756

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLV 1363
            KDG  L S+GR+ L   G R  L ++ AR+ DAG Y+  A  +  +   +    L V+  
Sbjct: 757  KDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNE--LGQATCAASLTVRPG 814

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDA----DVTWLRNGAVVTPGPQVEMAQNGSSRILTLR 1419
               +P +     D  +   +SPP+       TW R     TP  +   +QN  S      
Sbjct: 815  GSTSPFSSPITSDEEY---LSPPEEFPEPGETWPR-----TPTMKPSPSQNRRS------ 860

Query: 1420 GCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAG 1479
                 D G+   +A  T              F   L D    EGQDV + +   +     
Sbjct: 861  ----SDTGS---KAPPT--------------FKVSLMDQSVREGQDVIMSIRV-QGEPKP 898

Query: 1480 AVRWVRGGQPL-PHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RTLARLS 1534
             V W+R  QP+ P   R +   +G + RL I      D G Y C++ ++    +  ARL 
Sbjct: 899  VVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLE 958

Query: 1535 VRP----RQLRVLRPLEDVTISEGGSATFQ-LELSQEGVTGEWARGGVQLYPG-PKCHIH 1588
            VR     R L VL PL+DV +  G  A F+ L      V  +W   G  L P   KC +H
Sbjct: 959  VRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMH 1018

Query: 1589 SDGHRHRLVLNGLGLADSGC----VSFTADSLRCAARLIVR-EVPVTIVRGPHDLEVTEG 1643
             DG + +L+L  +   DSG     +S   D L C+ARL VR  +     R   D+EV EG
Sbjct: 1019 FDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEG 1078

Query: 1644 DTATFECELSQALAD-VTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYS 1699
              A F+C++S      VTW   G  +  S  LRL+  G    L +   G  D G Y+
Sbjct: 1079 RAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYA 1135



 Score =  111 bits (278), Expect = 6e-24
 Identities = 123/456 (26%), Positives = 182/456 (39%), Gaps = 74/456 (16%)

Query: 107  SDPELQPAERPLPSPGSGE-GAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDG 165
            + PEL+ ++    S G     APVF    ++  V  GA+V+L C     P P + W KDG
Sbjct: 700  TSPELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDG 759

Query: 166  MALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQ 225
             AL          L   RAE   G    L +  AR  D+G Y+  A N  G A   A L 
Sbjct: 760  SALR---SEGRLLL---RAE---GERHTLLLREARAADAGSYMATATNELGQATCAASLT 810

Query: 226  VH-------------------QPPESPPADPDEAP-APVVEPLKC-----------APKT 254
            V                     PPE  P   +  P  P ++P              AP T
Sbjct: 811  VRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSPSQNRRSSDTGSKAPPT 870

Query: 255  FWVN-------EGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
            F V+       EG+       V G+P+P + W    +P+ PD+RR       G   L++L
Sbjct: 871  FKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRIL 930

Query: 308  YCQAKDRGLYVCAARNSAG----QTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECK 363
              +  D G Y C A N  G    +    V+ H +   L    PLQDV+     +A+ EC 
Sbjct: 931  AAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECL 990

Query: 364  VPN-SRIPTAWFREDQRLLPC-RKYEQIEEGTVRRLIIHRLKADDDGIYLCEM---RGRV 418
            V   + +   W    + L P   K +   +G   +L++  +  DD G+Y C++   +  +
Sbjct: 991  VAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDEL 1050

Query: 419  RTVANVTVK---GPILKRLPRKLDVLEGENAVLLVETLEAGVEG------RWSRDG---E 466
               A +TV+    P+  RL   ++VLEG  A       +  + G       W+  G   E
Sbjct: 1051 TCSARLTVRPSLAPLFTRLLEDVEVLEGRAA-----RFDCKISGTPPPVVTWTHFGCPME 1105

Query: 467  ELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNS 502
            E   +     G +H+L +  V  ED G    S  N+
Sbjct: 1106 ESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNT 1141



 Score =  105 bits (262), Expect = 4e-22
 Identities = 179/711 (25%), Positives = 246/711 (34%), Gaps = 142/711 (19%)

Query: 5    SGDQGS--PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE-RLSFP 61
            S D GS  PP F        V  G +  +   V GEP PVV W +  Q +   + R +  
Sbjct: 860  SSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEE 919

Query: 62   ADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP 121
            A+G    L + AA   DAG Y C+A N  G     A + V   P S      A       
Sbjct: 920  AEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDV 979

Query: 122  GSGEGA--PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
            G+GE A     + GP         EV   CR G L +P L   K            HF  
Sbjct: 980  GAGEMALFECLVAGPTD------VEVDWLCR-GRLLQPALLKCK-----------MHF-- 1019

Query: 180  QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE 239
                     G    L + +    DSGVY C    A       A L V          P  
Sbjct: 1020 --------DGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVR---------PSL 1062

Query: 240  AP--APVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRD 297
            AP    ++E ++       V EG+ A+F C + G P P + W   G P + +   L  R 
Sbjct: 1063 APLFTRLLEDVE-------VLEGRAARFDCKISGTPPPVVTWTHFGCP-MEESENLRLRQ 1114

Query: 298  RDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLR--------------- 342
              G   L + +  ++D GLY  +A N+ GQ   + QL+V+EPR                 
Sbjct: 1115 DGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIP 1174

Query: 343  ---------------FTRPLQDVEGREHGIAVLECKVPNSRIPT-AWFREDQRLLPCRKY 386
                           F RPLQD+E      A+LEC+V     PT +WF    R+      
Sbjct: 1175 EEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDR 1234

Query: 387  EQIEEGTVRRLIIHRLKADDDGIY---LCEMRGRVRTVANVTVKGPILKRLPRKLDVLEG 443
               +   V RL+   +     G+Y   +    G+    A++ V            DV+ G
Sbjct: 1235 RMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYV-----------TDVVPG 1283

Query: 444  --ENAVLLVETLEAGVEGRWSR--------DGEELPVICQS---SSGHMHALVLPGVTRE 490
              + A  +V      V   W+         D + L    Q     S    ALV  G+   
Sbjct: 1284 PPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALV-TGLREP 1342

Query: 491  DAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTV----LLTWKPP----- 541
                     G      +L       S P PP        H  T+     +  KP      
Sbjct: 1343 GWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPVQLLEHGPTLEEAPAMLDKPDIVYVV 1402

Query: 542  --EPAPETPFIYRLERQEVGSEDWIQCFSI---EKAGAVEVPGDCVPSEGDYRFRICTVS 596
              +PA  T     +E Q V    W  C       +AG  E+     P +  Y  RIC VS
Sbjct: 1403 EGQPASVTVTFNHVEAQVV----WRSCRGALLEARAGVYEL---SQPDDDQYCLRICRVS 1455

Query: 597  GHGRSPHVVFHGSAH----------LVPTARLVAGLEDVQVYDGEDAVFSL 637
                        + H          L    R  + +EDV+V  GE A F++
Sbjct: 1456 RRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVGAGETARFAV 1506



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 166/676 (24%), Positives = 250/676 (36%), Gaps = 128/676 (18%)

Query: 1076 APPERIVHPAARSLD-LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAE-- 1132
            APP R   P A+++  L +  PG   L     P   +    K+    EA   L+ G E  
Sbjct: 625  APPGRKREPPAQAVRFLPWATPG---LEGAAVPQTLE----KNRAGPEAEKRLRRGPEED 677

Query: 1133 GPTRTLTLPHAQPEDAGEYVCETRHEAITFN---VILAEPPVQFLALETTPSPLCVAPGE 1189
            GP        A+ +  G     T  E  + +   V   E P++    E     + VAPG 
Sbjct: 678  GPWGPWDRRGARSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGA 737

Query: 1190 PVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLY----- 1243
             V+L C ++    P V W  +G  ++    L L AEG R  L ++ A  A AG Y     
Sbjct: 738  DVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATAT 797

Query: 1244 ------TCQSGAA--PGAPSLSFTVQVAE------------------PPVRVVAPEAAQT 1277
                  TC +     PG  +  F+  +                    P    + P  +Q 
Sbjct: 798  NELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSPSQN 857

Query: 1278 RVRSTPGG-------------------DLELVVHLSGPGGPV-RWYKDGERLASQGRVQL 1317
            R  S  G                    D+ + + + G   PV  W ++ + +    R   
Sbjct: 858  RRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFA 917

Query: 1318 EQA-GARQVLRVQGARSGDAGEYLCDAPQD-------SRIFLVSVEEPLLVKLVSELTPL 1369
            E+A G    LR+  A  GDAG Y C A  +       +R+ + +  E   + +++ L  +
Sbjct: 918  EEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDV 977

Query: 1370 TVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGP-QVEMAQNGSSRILTLRGCQLGDAG 1427
             V  G+ A F C V+ P D +V WL  G ++ P   + +M  +G    L L      D+G
Sbjct: 978  DVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSG 1037

Query: 1428 TVTLRAGST----ATSARLHVRETEL-LFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVR 1482
              T +  +       SARL VR +   LF R L+DV   EG+    + +         V 
Sbjct: 1038 VYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPP-VVT 1096

Query: 1483 WVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVR------ 1536
            W   G P+     L + QDG +H L I  V   D+G Y   + +    A  S +      
Sbjct: 1097 WTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEP 1156

Query: 1537 --------------------PRQLRV--------LRPLEDVTISEGGSATFQLELSQEGV 1568
                                P Q  +        LRPL+D+ +  G +    LE    G+
Sbjct: 1157 RTAASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEV--GLAKEAMLECQVTGL 1214

Query: 1569 ---TGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCV-SFTADSL---RCAAR 1621
               T  W   G ++       +      HRLV   +G   +G   S  A+ L    C A 
Sbjct: 1215 PYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAH 1274

Query: 1622 LIVREVPVTIVRGPHD 1637
            L V +V    V GP D
Sbjct: 1275 LYVTDV----VPGPPD 1286



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 124/531 (23%), Positives = 189/531 (35%), Gaps = 65/531 (12%)

Query: 768  GRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVML 827
            GR+ R   PE +  D        E + A         PV  + P ++V V       V+L
Sbjct: 694  GRRARPTSPELESSDDSYVSAGEEPLEA---------PVFEI-PLQNVVV--APGADVLL 741

Query: 828  ACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECA 886
             C +     P V W+KDG  +     ++L  EG    L+L   + +D G +   A +E  
Sbjct: 742  KCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNELG 801

Query: 887  YFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLL 946
              T      +S  V P G              T     P           E    P    
Sbjct: 802  QATC----AASLTVRPGGS-------------TSPFSSPITSDEEYLSPPEEFPEPGETW 844

Query: 947  QKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLEC 1006
             +  T++       +  D+G           +F V++ +  VR               + 
Sbjct: 845  PRTPTMKPSPSQNRRSSDTG------SKAPPTFKVSLMDQSVR-------------EGQD 885

Query: 1007 VVLMCELSREDAP-VRWYKDGLEVE-ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
            V++   +  E  P V W ++   V  +      E +G  CRL + AA+  D G + C A 
Sbjct: 886  VIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAV 945

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSL-------DLHFGAPGRVELRCEVA-PAGSQVRWYK 1116
            ++  +      A  E   HP +RSL       D+  GA       C VA P   +V W  
Sbjct: 946  NE--YGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLC 1003

Query: 1117 DG-LEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCE--TRHEAITFNVILAEPPVQF 1173
             G L   A    ++  +G    L L     +D+G Y C+  T  + +T +  L   P   
Sbjct: 1004 RGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLA 1063

Query: 1174 LALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCI 1232
                     + V  G      C++S    PVV W+H G P++E E L L  +G    L I
Sbjct: 1064 PLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHI 1123

Query: 1233 QAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTP 1283
               G    GLY   +    G    S  + V EP      P +   ++ S P
Sbjct: 1124 AHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIP 1174



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 123/532 (23%), Positives = 193/532 (36%), Gaps = 109/532 (20%)

Query: 1455 LQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVIL 1514
            LQ+V    G DV L+           V W + G  L  + RL +  +G  H L +     
Sbjct: 728  LQNVVVAPGADVLLKCII-TANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARA 786

Query: 1515 ADQGTYGCESHHD----RTLARLSVRP------------RQLRVLRPLEDVT-------- 1550
            AD G+Y   + ++       A L+VRP                 L P E+          
Sbjct: 787  ADAGSYMATATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPR 846

Query: 1551 -------------ISEGGSA---TFQLELSQEGVT------------GE------WARGG 1576
                          S+ GS    TF++ L  + V             GE      W R  
Sbjct: 847  TPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNR 906

Query: 1577 VQLYPGPKCHIH-SDGHRHRLVLNGLGLADSGCVSFTA----DSLRCAARLIVREVP--- 1628
              + P  +     ++G   RL +      D+G  +  A     + +C ARL VR  P   
Sbjct: 907  QPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESR 966

Query: 1629 -VTIVRGPHDLEVTEGDTATFECELSQAL-ADVTWEKDGNALTPSP-RLRLQALGTRRLL 1685
             + ++    D++V  G+ A FEC ++     +V W   G  L P+  + ++   G +  L
Sbjct: 967  SLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKL 1026

Query: 1686 QLRRCGPSDAGTYSCAVGTAR---AGPVRLTVRERTVAVLSEL-RSVSAREGDGATFECT 1741
             L      D+G Y+C + TA+       RLTVR     + + L   V   EG  A F+C 
Sbjct: 1027 LLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCK 1086

Query: 1742 VSEVET-TGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA-------- 1792
            +S        W   G P+     +R+RQ+G  H L ++ + +ED G     A        
Sbjct: 1087 ISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAH 1146

Query: 1793 ---------------GPAQSLALL----------EVEALPLQMCRHPPREKTVLVGRRAV 1827
                           GP+  L  +          E+E L +     P ++  V + + A+
Sbjct: 1147 CSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAM 1206

Query: 1828 LEVTVSRSG-GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
            LE  V+      + W   G  +   D   M  +   H LV   V P+  G Y
Sbjct: 1207 LECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVY 1258



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 102/442 (23%), Positives = 157/442 (35%), Gaps = 78/442 (17%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
            S P FLR  + + V    EA L+C V G P P + W   G ++ +S+          H L
Sbjct: 1186 SIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRL 1245

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
            +  A  P  AGVY     N  G+A   A + V +                 PG  +GAP 
Sbjct: 1246 VFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVV---------------PGPPDGAPQ 1290

Query: 130  FLTGPRSQWVLRGAEVVLTCRAGGL------PEPTLYWEKDGMALDEVWDSSHFAL-QPG 182
             +        + G  V LT            P+   Y  +  +   + W +    L +PG
Sbjct: 1291 VVA-------VTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPG 1343

Query: 183  RAEDG--PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADP--- 237
             A  G   G     R+L+  +  S                           SPP++P   
Sbjct: 1344 WAATGLRKGVQHIFRVLSTTVKSSS------------------------KPSPPSEPVQL 1379

Query: 238  -------DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDR 290
                   +EAPA + +P        +V EG+ A          E ++ W      LL  R
Sbjct: 1380 LEHGPTLEEAPAMLDKP-----DIVYVVEGQPASVTV-TFNHVEAQVVWRSCRGALLEAR 1433

Query: 291  RRL--MYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQ 348
              +  + +  D  + L++     +D G   C ARN  G    +V L + E   RF   ++
Sbjct: 1434 AGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAP-RFESIME 1492

Query: 349  DVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDD 407
            DVE      A     V    +P   W++++  L        + E     L++    A D 
Sbjct: 1493 DVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDG 1552

Query: 408  GIYLC---EMRGRVRTVANVTV 426
            G+Y C    + G V   A + V
Sbjct: 1553 GVYTCTAQNLAGEVSCKAELAV 1574



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 178/850 (20%), Positives = 281/850 (33%), Gaps = 145/850 (17%)

Query: 734  VVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDS--------- 783
            V+L C ++    P  +W+KDG  +     L+++ +G +H L+L EA+  D+         
Sbjct: 739  VLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATN 798

Query: 784  --GEFECRTE-------GVSAFFGVTVQD-----PPVHIVDPREH--------------- 814
              G+  C            S F      D     PP    +P E                
Sbjct: 799  ELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSPSQNR 858

Query: 815  -----------VFVHAITSECV------MLACEVDREDAPV-RWYKDGQEVEESDFVVLE 856
                        F  ++  + V      +++  V  E  PV  W ++ Q V        E
Sbjct: 859  RSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAE 918

Query: 857  N-EGPHRRLVLPATQPSDGGEFQCVAGDEC------AYFTVTITDVSSWIVYPSGKVYVA 909
              EG   RL + A +  D G + C A +E       A   V     S  +   +    V 
Sbjct: 919  EAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVD 978

Query: 910  AVRLERVVLTCELCRPW-AEVRWTKDGEEVVESPALLLQK---EDTVRRLVLPAVQLEDS 965
                E  +  C +  P   EV W   G  +   PALL  K   +    +L+L +V  +DS
Sbjct: 979  VGAGEMALFECLVAGPTDVEVDWLCRGRLL--QPALLKCKMHFDGRKCKLLLTSVHEDDS 1036

Query: 966  GEYLCEI----DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-V 1020
            G Y C++    D+ + S  +TV  P +  ++ R    +  +        C++S    P V
Sbjct: 1037 GVYTCKLSTAKDELTCSARLTV-RPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVV 1095

Query: 1021 RWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTVTA 1076
             W   G  +EESE L L +DG    L +     ED G +   A    G       + V  
Sbjct: 1096 TWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEE 1155

Query: 1077 PPERIVHPAAR---------------------------SLDLHFGAPGRVELRCEVAPAG 1109
            P      P+++                             DL  G      L C+V    
Sbjct: 1156 PRTAASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLP 1215

Query: 1110 -SQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEY---VCETRHEAITF--- 1162
               + W+ +G  +++SD  ++        L  P   P+ AG Y   +     +A  +   
Sbjct: 1216 YPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHL 1275

Query: 1163 ---NVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGL 1219
               +V+   P      +  T   + +    P  L   +          H      +   L
Sbjct: 1276 YVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTAL 1335

Query: 1220 ELHAEGPRRVLCIQAAGPAHAGLY---TCQSGAAPGAPS-----LSFTVQVAEPPVRVVA 1271
                  P         G  H       T +S + P  PS     L     + E P  +  
Sbjct: 1336 VTGLREPGWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPVQLLEHGPTLEEAPAMLDK 1395

Query: 1272 PEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERL--ASQGRVQLEQAGARQ-VLRV 1328
            P+     V    G    + V  +     V W      L  A  G  +L Q    Q  LR+
Sbjct: 1396 PDI----VYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRI 1451

Query: 1329 QGARSGDAGEYLCDA-----PQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV 1383
                  D G   C A      Q   + L   E P   +  S +  + V  G+ A F   V
Sbjct: 1452 CRVSRRDMGALTCTARNRHGTQTCSVTLELAEAP---RFESIMEDVEVGAGETARFAVVV 1508

Query: 1384 -SPPDADVTWLRNGAVVTPGPQVEMA--QNGSSRILTLRGCQLGDAGTVTLR--AGSTAT 1438
               P  D+ W ++  ++T    V     +N  S ++   G Q G   T T +  AG  + 
Sbjct: 1509 EGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSC 1568

Query: 1439 SARLHVRETE 1448
             A L V   +
Sbjct: 1569 KAELAVHSAQ 1578



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 49/158 (31%), Positives = 70/158 (44%), Gaps = 27/158 (17%)

Query: 85  RARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGE----GAPVFLTGPRSQWVL 140
           +AR   GE     A     PP+  P + P    + + G       GAPVFL   ++  V 
Sbjct: 3   KARGTRGEDAGTRA-----PPS--PGVPPKRAKVGAGGGAPVAVAGAPVFLRPLKNAAVC 55

Query: 141 RGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAAR 200
            G++V L     G P+P+L W +DG  L            P  A +   + L LR   A+
Sbjct: 56  AGSDVRLRVVVSGTPQPSLRWFRDGQLL------------PAPAPE--PSCLWLRRCGAQ 101

Query: 201 LPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPD 238
             D+GVY C A+N  G A   A+L V +  +S  A+ D
Sbjct: 102 --DAGVYSCMAQNERGRASCEAVLTVLEVGDSETAEDD 137



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 36/93 (38%), Positives = 45/93 (48%), Gaps = 9/93 (9%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL- 70
           P FLR  +   V +G++  L+ VV G P P + W + GQ L        PA   E   L 
Sbjct: 43  PVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLL--------PAPAPEPSCLW 94

Query: 71  LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLE 103
           L      DAGVY C A+N  G A   A +TVLE
Sbjct: 95  LRRCGAQDAGVYSCMAQNERGRASCEAVLTVLE 127



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 63/220 (28%), Positives = 81/220 (36%), Gaps = 38/220 (17%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQL----AASERLSFPADGAEH 67
            P  L  P  V VV G  A +  V        VVW      L    A    LS P D  ++
Sbjct: 1390 PAMLDKPDIVYVVEGQPASVT-VTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDD-QY 1447

Query: 68   GLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
             L +      D G   C ARN  G    +  + + E P  +  ++  E      G+GE A
Sbjct: 1448 CLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVE-----VGAGETA 1502

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
                         R A VV      G P P + W KD + L E   SSH +      E  
Sbjct: 1503 -------------RFAVVV-----EGKPLPDIMWYKDEVLLTE---SSHVSFVYEENE-- 1539

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVH 227
                 +L +L+    D GVY C A+N  G     A L VH
Sbjct: 1540 ----CSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVH 1575



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 88/398 (22%), Positives = 154/398 (38%), Gaps = 65/398 (16%)

Query: 622  LEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRL 681
            L D  V +G+D + S+     +QG        L++ +P   V P   R+  E +G   RL
Sbjct: 875  LMDQSVREGQDVIMSIR----VQGEPKPVVSWLRNRQP---VRPDQRRFAEEAEGGLCRL 927

Query: 682  ILHAVKHQDSGALVGFSCPGVQD------SAALTIQESP----VHILSPQDRVSLTFTTS 731
             + A +  D+G    ++C  V +       A L ++  P    + +L+P   V +     
Sbjct: 928  RILAAERGDAGF---YTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVG--AG 982

Query: 732  ERVVLTCELSR-VDFPATWYKDGQKVEESELLVVKM--DGRKHRLILPEAKVQDSGEFEC 788
            E  +  C ++   D    W   G+ ++ + LL  KM  DGRK +L+L      DSG + C
Sbjct: 983  EMALFECLVAGPTDVEVDWLCRGRLLQPA-LLKCKMHFDGRKCKLLLTSVHEDDSGVYTC 1041

Query: 789  R----TEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKD 843
            +     + ++    +TV+ P +  +  R    V  +        C++     P V W   
Sbjct: 1042 KLSTAKDELTCSARLTVR-PSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHF 1100

Query: 844  GQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWI 899
            G  +EES+ + L  +G    L +      D G +   A    G       + + +  +  
Sbjct: 1101 GCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAA 1160

Query: 900  VYPSGKVYVAAV--------RLERV--------------------VLTCELC-RPWAEVR 930
              PS K+              LER+                    +L C++   P+  + 
Sbjct: 1161 SGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTIS 1220

Query: 931  WTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
            W  +G  +  S    + +   V RLV PAV  + +G Y
Sbjct: 1221 WFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVY 1258



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 34/111 (30%), Positives = 53/111 (47%), Gaps = 6/111 (5%)

Query: 1169 PPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQ-EGEGLELHAEGP 1226
            PPV  + L+       +  GE   L C  +   AP + W  + + ++ E   + +  +  
Sbjct: 2583 PPVFHIKLKDQ----VLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDG 2638

Query: 1227 RRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQT 1277
            R++L I  AG  HAGLY C +    G+ + S TV VA  P ++  PE  QT
Sbjct: 2639 RQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQT 2689



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 39/135 (28%), Positives = 56/135 (41%), Gaps = 19/135 (14%)

Query: 1565 QEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIV 1624
            ++G  G W R G +            G R R     L  +D   VS   + L       V
Sbjct: 676  EDGPWGPWDRRGARS--------QGKGRRARPTSPELESSDDSYVSAGEEPLEAP----V 723

Query: 1625 REVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRR 1683
             E+P+       ++ V  G     +C ++      V+W KDG+AL    RL L+A G R 
Sbjct: 724  FEIPL------QNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERH 777

Query: 1684 LLQLRRCGPSDAGTY 1698
             L LR    +DAG+Y
Sbjct: 778  TLLLREARAADAGSY 792



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 34/94 (36%), Positives = 40/94 (42%), Gaps = 21/94 (22%)

Query: 1661 WEKDGNAL-TPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTV 1719
            W +DG  L  P+P            L LRRCG  DAG YSC     R        R    
Sbjct: 76   WFRDGQLLPAPAPE--------PSCLWLRRCGAQDAGVYSCMAQNERG-------RASCE 120

Query: 1720 AVLSELRSVSAREGDGATFECTVSEVETTGRWEL 1753
            AVL+ L       GD  T E  +S+V+ T R EL
Sbjct: 121  AVLTVL-----EVGDSETAEDDISDVQGTQRLEL 149



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 33/103 (32%), Positives = 44/103 (42%), Gaps = 19/103 (18%)

Query: 240 APAPV-VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL---LPDRRRLMY 295
           A APV + PLK A     V  G   + R  V G P+P + W  +G+ L    P+   L  
Sbjct: 40  AGAPVFLRPLKNAA----VCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWL 95

Query: 296 RDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
           R            C A+D G+Y C A+N  G+      L V E
Sbjct: 96  RR-----------CGAQDAGVYSCMAQNERGRASCEAVLTVLE 127



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 29/118 (24%), Positives = 48/118 (40%), Gaps = 2/118 (1%)

Query: 259  EGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYV 318
            EG+ A   C     P P I W  + + L  +   ++   +DG  +L +     +  GLY 
Sbjct: 2597 EGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYE 2656

Query: 319  CAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRE 376
            C+A N  G   S+  + V     +   P  +V       A++  K  +SR P  +  E
Sbjct: 2657 CSATNVLGSITSSCTVAVARVPGKLAPP--EVPQTYQDTALVLWKPGDSRAPCTYTLE 2712



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 32/119 (26%), Positives = 43/119 (36%), Gaps = 14/119 (11%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            PVF    + Q +L G    L C     P P + W KD  +L         + + GR    
Sbjct: 2584 PVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQ--- 2640

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQ------PPESPPADPDEA 240
                  L I  A    +G+Y C A N  G   +   + V +      PPE P    D A
Sbjct: 2641 -----LLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTA 2694



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 61/247 (24%), Positives = 91/247 (36%), Gaps = 24/247 (9%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPA--DGAEHG 68
            PP F    +   ++ G  A L C+    P P + W K  + L +   +   +  DG +  
Sbjct: 2583 PPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQL- 2641

Query: 69   LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTV------LEPPASDPELQPAERPLPSPG 122
            L +  A    AG+Y C A N  G   ++  V V      L PP      Q     L  PG
Sbjct: 2642 LSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTALVLWKPG 2701

Query: 123  SGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQ-P 181
                AP   T  R        E V    + G+P+   Y+    +    V  +  F +   
Sbjct: 2702 DSR-APCTYTLERRV----DGESVWHPVSSGIPD--CYYNVTHL---PVGVTVRFRVACA 2751

Query: 182  GRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPA-DPDEA 240
             RA  GP ++ + ++      DS         AH  A   +     +PP+SP +  P  A
Sbjct: 2752 NRAGQGPFSNSSEKVFVRGTQDSSAV---PSAAHQEAPVTSRPARARPPDSPTSLAPPLA 2808

Query: 241  PAPVVEP 247
            PA    P
Sbjct: 2809 PAAPTPP 2815



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 50/183 (27%), Positives = 71/183 (38%), Gaps = 39/183 (21%)

Query: 440  VLEGENAVLLVETLEAGVEG---RWSRDGEEL----PVICQSSSGHMHALVLPGVTREDA 492
            +LEGE A LL   L A        W +D + L     VI  S       L +P   +  A
Sbjct: 2595 LLEGEAATLLC--LPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHA 2652

Query: 493  G-------EVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
            G        V  S+ +S T  + RV       PG     E+ + +++T L+ WKP +   
Sbjct: 2653 GLYECSATNVLGSITSSCTVAVARV-------PGKLAPPEVPQTYQDTALVLWKPGD--S 2703

Query: 546  ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDC------VPSEGDYRFRICTVSGHG 599
              P  Y LER+  G   W    S        +P DC      +P     RFR+   +  G
Sbjct: 2704 RAPCTYTLERRVDGESVWHPVSS-------GIP-DCYYNVTHLPVGVTVRFRVACANRAG 2755

Query: 600  RSP 602
            + P
Sbjct: 2756 QGP 2758



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 40/172 (23%), Positives = 72/172 (41%), Gaps = 13/172 (7%)

Query: 927  AEVRWTKDGEEVVESPA---LLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD----ESASF 979
            A+V W      ++E+ A    L Q +D    L +  V   D G   C   +    ++ S 
Sbjct: 1418 AQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSV 1477

Query: 980  TVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLER 1039
            T+ + E P R     ++V + A       ++ E  +    + WYKD + + ES  +    
Sbjct: 1478 TLELAEAP-RFESIMEDVEVGAGETARFAVVVE-GKPLPDIMWYKDEVLLTESSHVSFVY 1535

Query: 1040 DGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDL 1091
            +   C LV+ +   +DGG + C A +        V+   E  VH A  ++++
Sbjct: 1536 EENECSLVVLSTGAQDGGVYTCTAQN----LAGEVSCKAELAVHSAQTAMEV 1583



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 2/67 (2%)

Query: 1637 DLEVTEGDTATFECELSQALAD-VTWEKDGNALTPSPRLRLQALGT-RRLLQLRRCGPSD 1694
            D  + EG+ AT  C  +   A  ++W KD  +L   P + + +    R+LL + R G   
Sbjct: 2592 DQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRH 2651

Query: 1695 AGTYSCA 1701
            AG Y C+
Sbjct: 2652 AGLYECS 2658



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 13/44 (29%), Positives = 24/44 (54%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
            V W ++G+ L    +  +R+ G  H+L++ + R  D G+Y   A
Sbjct: 753  VSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATA 796


>gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens]
          Length = 1326

 Score =  145 bits (366), Expect = 4e-34
 Identities = 112/431 (25%), Positives = 193/431 (44%), Gaps = 16/431 (3%)

Query: 654  LKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQES 713
            +K  EP  +++    +Y ++Q G ++ L++  V   D+G +   S    + SA LT+ + 
Sbjct: 269  IKGTEPL-RIQYSLGKYDVKQMGTKYMLVISNVNMNDAG-IYSLSVGDKRMSAELTVLDE 326

Query: 714  PVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESEL--LVVKMDGRKH 771
            P+  L     V +T    +  V    LS+ +    W  +G++++  +   + V  DG  H
Sbjct: 327  PLKFLGEMKPVKVT--ERQTAVFEIRLSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTH 384

Query: 772  RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEV 831
             L + +A++ DSGEF      +     +T+   P+  V   ++V V   +  C  L CE+
Sbjct: 385  TLKIKDARLSDSGEFSAEAGNLVQKAQLTIDRIPIKFVSNLKNVRVKERSRAC--LECEL 442

Query: 832  DREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA---GDECAYF 888
              +D  +RW KDGQ +       + +EG    L++   Q SDGGE+  VA   GD   Y+
Sbjct: 443  TSKDVTLRWKKDGQLLMHGTKYSMNHEGKRAELIIEDAQLSDGGEYTVVAMQDGDPTEYY 502

Query: 889  TVTITDVSSWI-VYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQ 947
            +  I  V   +    SG   V A       L   L     E  W KDG+E+ + P + + 
Sbjct: 503  STAIVTVEERLATVKSGMSDVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGMQIV 562

Query: 948  KEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLE-- 1005
            K+  V +L+ P++  E  G+Y        +  +V + +PP       + +   A+T++  
Sbjct: 563  KQGAVHKLIFPSMGPEHEGKYTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVG 622

Query: 1006 -CVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA 1063
                +      +  P V WYKDG+EV E E + +ER   +  L +     ED G  +   
Sbjct: 623  HTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKL 682

Query: 1064 GDDSAFFTVTV 1074
             +D    T T+
Sbjct: 683  KNDHGSATATL 693



 Score =  117 bits (294), Expect = 8e-26
 Identities = 148/647 (22%), Positives = 249/647 (38%), Gaps = 69/647 (10%)

Query: 1261 QVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKD-GERLASQGRVQLEQ 1319
            +  E P  V APE  +   R+   G+ +   H+S       W ++ G  +    ++  + 
Sbjct: 68   EFVEKPQPVTAPEGDKAVFRARVQGNAK--PHIS-------WKRESGIPIKESAKIFYDS 118

Query: 1320 AGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATF 1379
                 VL+++   S D+  Y C A  D    + +V              L V EG +   
Sbjct: 119  INKEHVLKLEPLTSDDSDNYKCIASNDHADAIYTVS-------------LLVTEGQEKMD 165

Query: 1380 RCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATS 1439
              ++         L+  A   P  + +   N    +  L      D   V +  G T   
Sbjct: 166  FKKM---------LKKRAPPAPKKKQKKVANEKEMLEILSKVPKKDFEKVCMEYGFTDFR 216

Query: 1440 ARLHV-----RETELLFLRRLQDVRAEEGQ-------DVCLEVETGRVGAAGAVRWVRGG 1487
              L       ++ E+  +R L+ +  +E +       D  +E++   V     + W++G 
Sbjct: 217  GLLRKLKEMKKKVEVEAIRILKPLEDKETKVDTTVVFDCIMELKDPNV----KMIWIKGT 272

Query: 1488 QPLPHDSRLS---MAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLR 1544
            +PL     L    + Q G  + L I  V + D G Y       R  A L+V    L+ L 
Sbjct: 273  EPLRIQYSLGKYDVKQMGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLG 332

Query: 1545 PLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHI--HSDGHRHRLVLNGLG 1602
             ++ V ++E  +A F++ LS++     W   G +L    K  I    DG  H L +    
Sbjct: 333  EMKPVKVTERQTAVFEIRLSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDAR 392

Query: 1603 LADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWE 1662
            L+DSG  S  A +L   A+L +  +P+  V    ++ V E   A  ECEL+     + W+
Sbjct: 393  LSDSGEFSAEAGNLVQKAQLTIDRIPIKFVSNLKNVRVKERSRACLECELTSKDVTLRWK 452

Query: 1663 KDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAV-----GTARAGPVRLTVRER 1717
            KDG  L    +  +   G R  L +     SD G Y+         T       +TV ER
Sbjct: 453  KDGQLLMHGTKYSMNHEGKRAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTVEER 512

Query: 1718 TVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVL 1777
               V S +  V A  G  A     +++ +  G W   G+ +     ++I ++G  H L+ 
Sbjct: 513  LATVKSGMSDVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGMQIVKQGAVHKLIF 572

Query: 1778 SELRAEDAGEVRFQAGPAQSLALLEVEALPL-------QMCRHPPREKTVLVGRRAVLEV 1830
              +  E  G+  F+A   +S A + +   P         +  H     TV VG  A ++V
Sbjct: 573  PSMGPEHEGKYTFRAKGTESEASVFIADPPTIDPSVLEALAAH---AITVKVGHTAHIKV 629

Query: 1831 TV-SRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQG 1876
                +    V W ++G E+   ++  M        L I +   ED G
Sbjct: 630  PFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSG 676



 Score =  117 bits (292), Expect = 1e-25
 Identities = 93/361 (25%), Positives = 160/361 (44%), Gaps = 15/361 (4%)

Query: 1535 VRPRQLRVLRPLEDVTISEGGSATFQ--LELSQEGVTGEWARGGVQL---YPGPKCHIHS 1589
            V    +R+L+PLED       +  F   +EL    V   W +G   L   Y   K  +  
Sbjct: 229  VEVEAIRILKPLEDKETKVDTTVVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQ 288

Query: 1590 DGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFE 1649
             G ++ LV++ + + D+G  S +    R +A L V + P+  +     ++VTE  TA FE
Sbjct: 289  MGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEMKPVKVTERQTAVFE 348

Query: 1650 CELSQALADVTWEKDGNALTPSPRLRLQAL--GTRRLLQLRRCGPSDAGTYSCAVGTARA 1707
              LS+   +  W+ +G  L    +  +     G    L+++    SD+G +S   G    
Sbjct: 349  IRLSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEAGNL-V 407

Query: 1708 GPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIR 1767
               +LT+    +  +S L++V  +E   A  EC ++  + T RW+  G+ L  G +  + 
Sbjct: 408  QKAQLTIDRIPIKFVSNLKNVRVKERSRACLECELTSKDVTLRWKKDGQLLMHGTKYSMN 467

Query: 1768 QEGKKHILVLSELRAEDAGE---VRFQAG-PAQ--SLALLEVEALPLQMCRHPPREKTVL 1821
             EGK+  L++ + +  D GE   V  Q G P +  S A++ VE   L   +    +    
Sbjct: 468  HEGKRAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTVEER-LATVKSGMSDVHAA 526

Query: 1822 VGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQ 1881
             G  A L V ++       WL++G E+      ++   G  H L+   + PE +G Y  +
Sbjct: 527  TGSPAELCVVLNDEKVEGVWLKDGKEITDLPGMQIVKQGAVHKLIFPSMGPEHEGKYTFR 586

Query: 1882 A 1882
            A
Sbjct: 587  A 587



 Score =  100 bits (250), Expect = 1e-20
 Identities = 133/641 (20%), Positives = 244/641 (38%), Gaps = 51/641 (7%)

Query: 801  VQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVR--WYKDGQEVEESDFVV---- 854
            V+   + I+ P E       T+  V+  C ++ +D  V+  W K G E     + +    
Sbjct: 229  VEVEAIRILKPLEDKETKVDTT--VVFDCIMELKDPNVKMIWIK-GTEPLRIQYSLGKYD 285

Query: 855  LENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLE 914
            ++  G    LV+     +D G +    GD+     +T+ D    + +      V     +
Sbjct: 286  VKQMGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEP--LKFLGEMKPVKVTERQ 343

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPA--LLLQKEDTVRRLVLPAVQLEDSGEYLCEI 972
              V    L +      W  +G+E+       + + ++     L +   +L DSGE+  E 
Sbjct: 344  TAVFEIRLSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEA 403

Query: 973  DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEES 1032
             +      +T+   P++ +     V +   +  C  L CEL+ +D  +RW KDG  +   
Sbjct: 404  GNLVQKAQLTIDRIPIKFVSNLKNVRVKERSRAC--LECELTSKDVTLRWKKDGQLLMHG 461

Query: 1033 EALVLERDGPRCRLVLPAAQPEDGGEFVCDA---GDDSAFFTVTVTAPPERIVHPAARSL 1089
                +  +G R  L++  AQ  DGGE+   A   GD + +++  +    ER+    +   
Sbjct: 462  TKYSMNHEGKRAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTVEERLATVKSGMS 521

Query: 1090 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
            D+H       EL   +     +  W KDG E+     +Q+  +G    L  P   PE  G
Sbjct: 522  DVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGMQIVKQGAVHKLIFPSMGPEHEG 581

Query: 1150 EYVCETRHEAITFNVILAEPP-VQFLALETTPS-PLCVAPGEPVVLSCELSRAGAP-VVW 1206
            +Y    +      +V +A+PP +    LE   +  + V  G    +         P V W
Sbjct: 582  KYTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHTAHIKVPFRGKPLPKVTW 641

Query: 1207 SHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
              +G  V E E + +     + +L I       +GL   +     G+ + +  + V + P
Sbjct: 642  YKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKNDHGSATATLHLSVLDRP 701

Query: 1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRW---YKDGERLASQGRVQLEQAGAR 1323
                            P G +E  + LSG    ++W     +G R  +Q  V+    G +
Sbjct: 702  --------------KPPQGRVEF-LELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKK 746

Query: 1324 QVLRVQGARSGDAGEYLCDAPQDS-----RIFLVS---VEEPLLVKLVSELTPLTVHEGD 1375
              +++ G   G    +  +  ++      RI  V+   V +PL  + V    P+      
Sbjct: 747  SWIKI-GEVDGKVTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAGNPIEPPGFA 805

Query: 1376 DATFRCEVSPPDADVTW---LRNGAVVTPGPQVEMAQNGSS 1413
                  +V+     +TW    ++G     G  VE  + GS+
Sbjct: 806  SQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSN 846



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 73/268 (27%), Positives = 118/268 (44%), Gaps = 9/268 (3%)

Query: 1629 VTIVRGPHDLEVTEGDTATFEC--ELSQALADVTWEKDGNALTPSPRLR---LQALGTRR 1683
            + I++   D E     T  F+C  EL      + W K    L     L    ++ +GT+ 
Sbjct: 234  IRILKPLEDKETKVDTTVVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQMGTKY 293

Query: 1684 LLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVS 1743
            +L +     +DAG YS +VG  R     LTV +  +  L E++ V   E   A FE  +S
Sbjct: 294  MLVISNVNMNDAGIYSLSVGDKRMS-AELTVLDEPLKFLGEMKPVKVTERQTAVFEIRLS 352

Query: 1744 EVETTGRWELGGRPLRPGAR--VRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALL 1801
            + E    W+  G+ L+   +  + + ++G  H L + + R  D+GE   +AG     A L
Sbjct: 353  KKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEAGNLVQKAQL 412

Query: 1802 EVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGP 1861
             ++ +P++   +    + V    RA LE  ++     + W ++G  L  G KY M   G 
Sbjct: 413  TIDRIPIKFVSNLKNVR-VKERSRACLECELTSKDVTLRWKKDGQLLMHGTKYSMNHEGK 471

Query: 1862 THSLVIHDVRPEDQGTYCCQAGQDSTHT 1889
               L+I D +  D G Y   A QD   T
Sbjct: 472  RAELIIEDAQLSDGGEYTVVAMQDGDPT 499



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 114/518 (22%), Positives = 210/518 (40%), Gaps = 33/518 (6%)

Query: 988  VRIIYP-RDEVTLIAVTLECVVLMCELSREDAPVR--WYK--DGLEVEESEALV-LERDG 1041
            +RI+ P  D+ T +  T   VV  C +  +D  V+  W K  + L ++ S     +++ G
Sbjct: 234  IRILKPLEDKETKVDTT---VVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQMG 290

Query: 1042 PRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVEL 1101
             +  LV+      D G +    GD      +TV   P + +    + + +        E+
Sbjct: 291  TKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEM-KPVKVTERQTAVFEI 349

Query: 1102 RCEVAPAGSQVRWYKDGLEVEASDALQL--GAEGPTRTLTLPHAQPEDAGEYVCETRHEA 1159
            R  ++       W  +G E++  D  ++    +G T TL +  A+  D+GE+  E  +  
Sbjct: 350  R--LSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEAGNLV 407

Query: 1160 ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGL 1219
                + +   P++F++       + V       L CEL+     + W  +G+ +  G   
Sbjct: 408  QKAQLTIDRIPIKFVS---NLKNVRVKERSRACLECELTSKDVTLRWKKDGQLLMHGTKY 464

Query: 1220 ELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRV 1279
             ++ EG R  L I+ A  +  G YT  +    G P+  ++  +     R+   ++  + V
Sbjct: 465  SMNHEGKRAELIIEDAQLSDGGEYTVVA-MQDGDPTEYYSTAIVTVEERLATVKSGMSDV 523

Query: 1280 RSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEY 1339
             +  G   EL V L+       W KDG+ +     +Q+ + GA   L          G+Y
Sbjct: 524  HAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGMQIVKQGAVHKLIFPSMGPEHEGKY 583

Query: 1340 LCDAP---QDSRIFLV---SVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTW 1392
               A     ++ +F+    +++  +L  L +    +TV  G  A  +      P   VTW
Sbjct: 584  TFRAKGTESEASVFIADPPTIDPSVLEALAAHA--ITVKVGHTAHIKVPFRGKPLPKVTW 641

Query: 1393 LRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFL 1452
             ++G  VT   +V M +     +LT+  C   D+G + L+  +   SA      T  L L
Sbjct: 642  YKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKNDHGSA------TATLHL 695

Query: 1453 RRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPL 1490
              L   +  +G+   LE+    V          GG+P+
Sbjct: 696  SVLDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPV 733



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 149/673 (22%), Positives = 255/673 (37%), Gaps = 103/673 (15%)

Query: 239 EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDR 298
           E P PV  P           EG  A FR  V G  +P I W  E    + +  ++ Y   
Sbjct: 71  EKPQPVTAP-----------EGDKAVFRARVQGNAKPHISWKRESGIPIKESAKIFYDSI 119

Query: 299 DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIA 358
           +   VLK+    + D   Y C A N     +  V L V E + +        +       
Sbjct: 120 NKEHVLKLEPLTSDDSDNYKCIASNDHADAIYTVSLLVTEGQEKMDFKKMLKKRAPPAPK 179

Query: 359 VLECKVPNSRIPTAWFREDQRLLPCRKYEQI--EEG-TVRRLIIHRLKADDDGIYLCEMR 415
             + KV N +       E    +P + +E++  E G T  R ++ +LK         EM+
Sbjct: 180 KKQKKVANEK----EMLEILSKVPKKDFEKVCMEYGFTDFRGLLRKLK---------EMK 226

Query: 416 GRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ-- 473
            +V   A   +K   L+    K+D     + ++  E  +  V+  W +  E L +     
Sbjct: 227 KKVEVEAIRILKP--LEDKETKVDTTVVFDCIM--ELKDPNVKMIWIKGTEPLRIQYSLG 282

Query: 474 ----SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRV--KCVKHSPPGPPILAEMF 527
                  G  + LV+  V   DAG  + S+G+ R +  L V  + +K      P+     
Sbjct: 283 KYDVKQMGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEMKPVKVTER 342

Query: 528 KGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGD 587
           +     + L+ K P       F+++   +E+  +D  +  ++ + G              
Sbjct: 343 QTAVFEIRLSKKEPN------FVWKFNGKELKRDDKYE-ITVSEDGLTHT---------- 385

Query: 588 YRFRICTVSGHGRSPHVVFHGSA-HLVPTARL---------VAGLEDVQVYDGEDAVFSL 637
            + +   +S  G      F   A +LV  A+L         V+ L++V+V +   A    
Sbjct: 386 LKIKDARLSDSGE-----FSAEAGNLVQKAQLTIDRIPIKFVSNLKNVRVKERSRACLEC 440

Query: 638 DL-STIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVG 696
           +L S  +   W          + +GQ+     +Y +  +G +  LI+   +  D G    
Sbjct: 441 ELTSKDVTLRW----------KKDGQLLMHGTKYSMNHEGKRAELIIEDAQLSDGGE--- 487

Query: 697 FSCPGVQD--------SAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPAT 748
           ++   +QD        +A +T++E    + S    V     T     L   L+       
Sbjct: 488 YTVVAMQDGDPTEYYSTAIVTVEERLATVKSGMSDVHA--ATGSPAELCVVLNDEKVEGV 545

Query: 749 WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHI 808
           W KDG+++ +   + +   G  H+LI P    +  G++  R +G  +   V + DPP   
Sbjct: 546 WLKDGKEITDLPGMQIVKQGAVHKLIFPSMGPEHEGKYTFRAKGTESEASVFIADPPT-- 603

Query: 809 VDPR--EHVFVHAITSECVMLA-CEVDREDAP---VRWYKDGQEVEESDFVVLENEGPHR 862
           +DP   E +  HAIT +    A  +V     P   V WYKDG EV E + V +E      
Sbjct: 604 IDPSVLEALAAHAITVKVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQA 663

Query: 863 RLVLPATQPSDGG 875
            L +      D G
Sbjct: 664 LLTISNCVREDSG 676



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 135/593 (22%), Positives = 229/593 (38%), Gaps = 86/593 (14%)

Query: 33  CVV-LGEPPPVVVWEKGGQQLAASERLS---FPADGAEHGLLLTAALPTDAGVYVCRARN 88
           C++ L +P   ++W KG + L     L        G ++ L+++     DAG+Y      
Sbjct: 255 CIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQMGTKYMLVISNVNMNDAGIYSL---- 310

Query: 89  AAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLT 148
           + G+   +A +TVL+ P                  GE  PV +T  ++       E+ L+
Sbjct: 311 SVGDKRMSAELTVLDEPLKF--------------LGEMKPVKVTERQTAVF----EIRLS 352

Query: 149 CRAGGLPEPTLYWEKDGMAL--DEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGV 206
            +     EP   W+ +G  L  D+ ++ +        +EDG   +  L+I  ARL DSG 
Sbjct: 353 KK-----EPNFVWKFNGKELKRDDKYEITV-------SEDG--LTHTLKIKDARLSDSGE 398

Query: 207 YVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFR 266
           +          A+AG L+Q  Q         D  P   V  L    K   V E   A   
Sbjct: 399 F---------SAEAGNLVQKAQ------LTIDRIPIKFVSNL----KNVRVKERSRACLE 439

Query: 267 CYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAG 326
           C +  K +  + W  +G+ L+   +  M  +     ++ +   Q  D G Y   A     
Sbjct: 440 CELTSK-DVTLRWKKDGQLLMHGTKYSMNHEGKRAELI-IEDAQLSDGGEYTVVAMQDGD 497

Query: 327 QT--LSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCR 384
            T   S   + V+E        + DV       A L   + + ++   W ++ + +    
Sbjct: 498 PTEYYSTAIVTVEERLATVKSGMSDVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLP 557

Query: 385 KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGP------ILKRL-PRK 437
             + +++G V +LI   +  + +G Y    +G   + A+V +  P      +L+ L    
Sbjct: 558 GMQIVKQGAVHKLIFPSMGPEHEGKYTFRAKG-TESEASVFIADPPTIDPSVLEALAAHA 616

Query: 438 LDVLEGENAVLLVETLEAGV-EGRWSRDGEELPV---ICQSSSGHMHALVLPGVTREDAG 493
           + V  G  A + V      + +  W +DG E+     +          L +    RED+G
Sbjct: 617 ITVKVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSG 676

Query: 494 EVTFSLGNSR-TTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP---APETPF 549
            +   L N   + T      V   P  P    E  +   + V + WK P+     P T F
Sbjct: 677 LILLKLKNDHGSATATLHLSVLDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQF 736

Query: 550 IYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGD-YRFRICTVSGHGRS 601
           I  +ER+ VG + WI+   ++  G V         EG  Y+FRI  V+  G S
Sbjct: 737 I--VERRAVGKKSWIKIGEVD--GKVTNFSTNKVEEGKAYQFRILAVNSEGVS 785



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 87/441 (19%), Positives = 176/441 (39%), Gaps = 35/441 (7%)

Query: 1191 VVLSC--ELSRAGAPVVWSHNGRPVQEGEGL---ELHAEGPRRVLCIQAAGPAHAGLYTC 1245
            VV  C  EL      ++W     P++    L   ++   G + +L I       AG+Y+ 
Sbjct: 251  VVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQMGTKYMLVISNVNMNDAGIYSL 310

Query: 1246 QSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKD 1305
                + G   +S  + V + P++ +        V+ T        + LS       W  +
Sbjct: 311  ----SVGDKRMSAELTVLDEPLKFLGE---MKPVKVTERQTAVFEIRLSKKEPNFVWKFN 363

Query: 1306 GERLASQGRVQL--EQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLV 1363
            G+ L    + ++   + G    L+++ AR  D+GE+  +A    +   ++++  + +K V
Sbjct: 364  GKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEAGNLVQKAQLTIDR-IPIKFV 422

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQL 1423
            S L  + V E   A   CE++  D  + W ++G ++  G +  M   G    L +   QL
Sbjct: 423  SNLKNVRVKERSRACLECELTSKDVTLRWKKDGQLLMHGTKYSMNHEGKRAELIIEDAQL 482

Query: 1424 GDAGTVTLRAGSTA------TSARLHVRETELLFLRRLQDVRAEEGQ--DVCLEVETGRV 1475
             D G  T+ A          ++A + V E        + DV A  G   ++C+ +   +V
Sbjct: 483  SDGGEYTVVAMQDGDPTEYYSTAIVTVEERLATVKSGMSDVHAATGSPAELCVVLNDEKV 542

Query: 1476 GAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY-----GCESHHDRTL 1530
                   W++ G+ +     + + + G +H+L    +    +G Y     G ES     +
Sbjct: 543  EGV----WLKDGKEITDLPGMQIVKQGAVHKLIFPSMGPEHEGKYTFRAKGTESEASVFI 598

Query: 1531 A-RLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTG-EWARGGVQLYPGPKCHIH 1588
            A   ++ P  L  L     +T+  G +A  ++    + +    W + G+++    +  + 
Sbjct: 599  ADPPTIDPSVLEAL-AAHAITVKVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSME 657

Query: 1589 SDGHRHRLVLNGLGLADSGCV 1609
                +  L ++     DSG +
Sbjct: 658  RGEDQALLTISNCVREDSGLI 678



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 51/188 (27%), Positives = 79/188 (42%), Gaps = 8/188 (4%)

Query: 1714 VRERTVAVLSELRSVSAREGDGATFECTVSEVETTGR--WELGGRPLRPG---ARVRIRQ 1768
            V    + +L  L     +      F+C +   +   +  W  G  PLR      +  ++Q
Sbjct: 229  VEVEAIRILKPLEDKETKVDTTVVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQ 288

Query: 1769 EGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVL 1828
             G K++LV+S +   DAG      G  +  A L V   PL+        K V   + AV 
Sbjct: 289  MGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEMKPVK-VTERQTAVF 347

Query: 1829 EVTVSRSGGHVCWLREGAELCPGDKYEMR--SHGPTHSLVIHDVRPEDQGTYCCQAGQDS 1886
            E+ +S+   +  W   G EL   DKYE+     G TH+L I D R  D G +  +AG   
Sbjct: 348  EIRLSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEAGNLV 407

Query: 1887 THTRLLVE 1894
               +L ++
Sbjct: 408  QKAQLTID 415



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 75/328 (22%), Positives = 115/328 (35%), Gaps = 50/328 (15%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
           P  F+   + VRV   + A L+C +  +    + W+K GQ L    + S   +G    L+
Sbjct: 418 PIKFVSNLKNVRVKERSRACLECELTSKDV-TLRWKKDGQLLMHGTKYSMNHEGKRAELI 476

Query: 71  LTAALPTDAGVYVCRARNAAG--EAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
           +  A  +D G Y   A       E Y+ A VTV E       L   +  +    +  G+P
Sbjct: 477 IEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTVEE------RLATVKSGMSDVHAATGSP 530

Query: 129 VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
             L    +   + G                  W KDG  + ++         PG      
Sbjct: 531 AELCVVLNDEKVEGV-----------------WLKDGKEITDL---------PGMQIVKQ 564

Query: 189 GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
           GA   L   +      G Y   A+     A                ADP      V+E L
Sbjct: 565 GAVHKLIFPSMGPEHEGKYTFRAKGTESEASVFI------------ADPPTIDPSVLEAL 612

Query: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
             A     V  G  A  +    GKP P++ W+ +G  +  + R  M R  D   +L +  
Sbjct: 613 --AAHAITVKVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQA-LLTISN 669

Query: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHV 336
           C  +D GL +   +N  G   + + L V
Sbjct: 670 CVREDSGLILLKLKNDHGSATATLHLSV 697



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 24/85 (28%), Positives = 42/85 (49%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAG 80
           + V  G  A +K    G+P P V W K G ++   ER+S      +  L ++  +  D+G
Sbjct: 617 ITVKVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSG 676

Query: 81  VYVCRARNAAGEAYAAAAVTVLEPP 105
           + + + +N  G A A   ++VL+ P
Sbjct: 677 LILLKLKNDHGSATATLHLSVLDRP 701



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 81/335 (24%), Positives = 118/335 (35%), Gaps = 39/335 (11%)

Query: 11   PPCFLRFPRPVRVVS------GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
            PP   +F    R+ S      G    +     G PPP V+W+K G      E ++   + 
Sbjct: 998  PPAAPKFDLSARLKSHMVVRAGTALCIHAAFSGSPPPDVIWQKDGVPTKGRETITKSKNH 1057

Query: 65   AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSG 124
            ++   L+ +   +D+GVY    +N  GEA     V V + P     L+  E  +P+    
Sbjct: 1058 SQ--FLINSTKRSDSGVYRILLQNEFGEARYDIHVRVADFPRPPTNLRLFEE-VPN---- 1110

Query: 125  EGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSH--FALQPG 182
                V LT   S  V    E             T Y      A + V+ + +    L PG
Sbjct: 1111 ---TVTLTWNHSPDVQEDGEAHYIIMKRDASTATWY-----TAAERVFSNKYTVTGLLPG 1162

Query: 183  RAEDGPGASLALRILAA-RLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAP 241
            R           R++A   + DS              Q   L    +P E    D   AP
Sbjct: 1163 R-------KYYFRVVARNEIGDSEPLDSRDTWLINKDQIQDLSAKLKPYEK--KDWRHAP 1213

Query: 242  APVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGG 301
               V PLK  P T  V  G+     C  +G P P +   ++G   +    +  Y    G 
Sbjct: 1214 R-FVTPLK--PHT--VLRGQDCTMTCAFLGNPRPTVTL-YKGDVNITANSKFWYNSTSGV 1267

Query: 302  FVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV 336
              L +  C  KD G Y     N  G+  S+  L V
Sbjct: 1268 CTLVIPTCTLKDSGDYSVLVENELGKDRSSCTLTV 1302



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 26/95 (27%), Positives = 42/95 (44%), Gaps = 1/95 (1%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEK-GGQQLAASERLSFPADGAEHG 68
           S P F+  P+PV    G +A  +  V G   P + W++  G  +  S ++ + +   EH 
Sbjct: 65  SVPEFVEKPQPVTAPEGDKAVFRARVQGNAKPHISWKRESGIPIKESAKIFYDSINKEHV 124

Query: 69  LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLE 103
           L L      D+  Y C A N   +A    ++ V E
Sbjct: 125 LKLEPLTSDDSDNYKCIASNDHADAIYTVSLLVTE 159



 Score = 39.3 bits (90), Expect = 0.037
 Identities = 22/92 (23%), Positives = 40/92 (43%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
            P F+   +P  V+ G +  + C  LG P P V   KG   + A+ +  + +      L++
Sbjct: 1213 PRFVTPLKPHTVLRGQDCTMTCAFLGNPRPTVTLYKGDVNITANSKFWYNSTSGVCTLVI 1272

Query: 72   TAALPTDAGVYVCRARNAAGEAYAAAAVTVLE 103
                  D+G Y     N  G+  ++  +TV +
Sbjct: 1273 PTCTLKDSGDYSVLVENELGKDRSSCTLTVYD 1304


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  143 bits (361), Expect = 1e-33
 Identities = 192/716 (26%), Positives = 301/716 (42%), Gaps = 101/716 (14%)

Query: 778  AKVQDSGEFEC----RTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDR 833
            A   + G +EC    R     A   + V DPP  +V P  +V V     E  +L+C V  
Sbjct: 369  ASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV-PAPNVTVSP--GETAVLSCRVLG 425

Query: 834  EDAP--VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVT 891
            E AP  + W +D + +  S   V +       L +    P+DGG +QCVA +        
Sbjct: 426  E-APYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANG----- 477

Query: 892  ITDVSSWIVY---PSGKVYVAAVRLERVVLTCELCR----PWAEVRWTKDGEEVVESPAL 944
            +T  S W++    P   ++ ++    + V     C     P   + W+++ + + E   +
Sbjct: 478  VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI 537

Query: 945  LLQKEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRIIYPRDEVTLI 1000
             +  + T   L++  V  ED+G Y C    E+  +  + T+  T+PP   +   + V L+
Sbjct: 538  HVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP--SVSAVNAVVLV 592

Query: 1001 AVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRC-RLVLPAAQPEDGGE 1058
            AV  E  VL+CE S    P V WY+ GLE      ++L  +G    +L +PAAQ  D G 
Sbjct: 593  AVGEE-AVLVCEASGVPPPRVIWYRGGLE------MILAPEGSSSGKLRIPAAQERDAGT 645

Query: 1059 FVCDA----GDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRW 1114
            + C A    GD SA   + V   P+    P  R + +  G    +  R    P  + V W
Sbjct: 646  YTCRAVNELGDASAEIQLAVGHAPQLTELP--RDVTVELGRSALLACRATGRPPPT-VTW 702

Query: 1115 YK-DGLEVEASDALQLGAEGPTRT-------LTLPHAQPEDAGEYVCETRH-----EAIT 1161
             + DG  +     L+LGA   +R+       L      PED   YVCE R+     +A  
Sbjct: 703  RRGDGQPL----GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEA 758

Query: 1162 FNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV---WSHNGRPVQEGEG 1218
              ++    P Q  +   T   + V  G+PV L C +  AG P+    W  +GRP+  G  
Sbjct: 759  RLIVTGHAPPQIASSAPT---VRVLEGQPVSLPC-IVLAGRPLPERHWLKDGRPLPPGSR 814

Query: 1219 LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTR 1278
              + A+G    L +  A   HAG Y+C +    G+      + V  PP   + P A  T 
Sbjct: 815  HSIRADGS---LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP--RIHPTA--TH 867

Query: 1279 VRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQG-RVQLEQAGARQVLRVQGARSGDA 1336
              +  G    L    SG P   + W K+   L S+G    + + G    L +    + DA
Sbjct: 868  HITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDA 924

Query: 1337 GEYLCDAPQ----DSRIFLVSVEEPLLVKL-----VSELTPLTVHEGDDATFRCEV--SP 1385
            G Y+C A       S+   +SV     + +      +    +T   G++ T  CE   SP
Sbjct: 925  GAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSP 984

Query: 1386 PDADVTWLRNGAVVTP-GPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSA 1440
            P   VTW ++   V P   +  +  +GS R+  +   Q+GD+G     A + A SA
Sbjct: 985  PPL-VTWTKDSRPVPPITNRYGLLPSGSLRLAQV---QVGDSGHYECTASNPAGSA 1036



 Score =  129 bits (323), Expect = 4e-29
 Identities = 142/502 (28%), Positives = 186/502 (37%), Gaps = 122/502 (24%)

Query: 11   PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            PP        V V  G EA L C   G PPP V+W +GG ++  +     P   +   L 
Sbjct: 580  PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILA-----PEGSSSGKLR 634

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
            + AA   DAG Y CRA N  G+A A   + V                         AP  
Sbjct: 635  IPAAQERDAGTYTCRAVNELGDASAEIQLAV-----------------------GHAPQL 671

Query: 131  LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
               PR   V  G   +L CRA G P PT+ W +                       G G 
Sbjct: 672  TELPRDVTVELGRSALLACRATGRPPPTVTWRR-----------------------GDGQ 708

Query: 191  SLALRILA-----ARLPDSGV-------------YVCHARNAHGHAQAGALLQV--HQPP 230
             L LR+ A     +R PDSGV             YVC ARN  G  QA A L V  H PP
Sbjct: 709  PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768

Query: 231  ESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVM-GKPEPEIEWHWEGRPLLPD 289
            +   + P                T  V EG+     C V+ G+P PE  W  +GRPL P 
Sbjct: 769  QIASSAP----------------TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPG 812

Query: 290  RRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQD 349
             R  +  D      L +     +  G Y C A N+AG     V+L V+ P      P   
Sbjct: 813  SRHSIRADGS----LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR--IHPTAT 866

Query: 350  VEGREHGI-AVLECKVPNSRIPTAWFREDQRLLPCR--KYEQIEEGTVRRLIIHRLKADD 406
                  G+ A L C       PT  + ++   L  R   Y   +EGT   L+I +  A D
Sbjct: 867  HHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGT---LLIAQPSAQD 923

Query: 407  DGIYLC-----------EMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEA 455
             G Y+C           EMR  V T   + + G     +P ++    GE       TL+ 
Sbjct: 924  AGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV-----TLDC 978

Query: 456  GVEG------RWSRDGEELPVI 471
              +G       W++D   +P I
Sbjct: 979  EAKGSPPPLVTWTKDSRPVPPI 1000



 Score =  109 bits (273), Expect = 2e-23
 Identities = 139/525 (26%), Positives = 194/525 (36%), Gaps = 82/525 (15%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
           PP  +  P  V V  G  A L C VLGE P  + W +  + L AS      A  A+  L 
Sbjct: 400 PPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST--GRVAQLADLSLE 456

Query: 71  LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
           ++  +PTD G Y C A NA G   A+  + V E                       AP  
Sbjct: 457 ISGIIPTDGGRYQCVASNANGVTRASVWLLVRE-----------------------APQV 493

Query: 131 LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
                SQ   +G EV ++C A G P P + W ++  AL E  DS       G        
Sbjct: 494 SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIHVDAQG-------- 543

Query: 191 SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
              L I      D+G Y C A N  G  Q    L    PP                 +  
Sbjct: 544 --TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS----------------VSA 585

Query: 251 APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
                 V  G+ A   C   G P P + W+  G  +      ++  +      L++   Q
Sbjct: 586 VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM------ILAPEGSSSGKLRIPAAQ 639

Query: 311 AKDRGLYVCAARNSAGQTLSAVQLHV-KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRI 369
            +D G Y C A N  G   + +QL V   P+L  T   +DV       A+L C+      
Sbjct: 640 ERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPP 697

Query: 370 PT-AWFREDQRLLPCR-------KYEQIEEGTVRRLIIHRLKADDDGIYLCEMR---GRV 418
           PT  W R D + L  R       +  Q + G    L    +  +D   Y+CE R   G+V
Sbjct: 698 PTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGV---LFFESVAPEDQAPYVCEARNVFGKV 754

Query: 419 RTVANVTVKG---PILKRLPRKLDVLEGENAVL--LVETLEAGVEGRWSRDGEELPVICQ 473
           +  A + V G   P +      + VLEG+   L  +V       E  W +DG  LP   +
Sbjct: 755 QAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR 814

Query: 474 SSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPP 518
            S     +L L    +E AG  +    N+  +    V+ V   PP
Sbjct: 815 HSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859



 Score =  103 bits (256), Expect = 2e-21
 Identities = 114/421 (27%), Positives = 149/421 (35%), Gaps = 76/421 (18%)

Query: 9    GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKG-GQQL------AASERLSFP 61
            G  P     PR V V  G  A L C   G PPP V W +G GQ L          R   P
Sbjct: 666  GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQP 725

Query: 62   ADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSP 121
              G    L   +  P D   YVC ARN  G+  A A + V                    
Sbjct: 726  DSGV---LFFESVAPEDQAPYVCEARNVFGKVQAEARLIV-------------------- 762

Query: 122  GSGEGAPVFLTGPRSQWVLRGAEVVLTCRA-GGLPEPTLYWEKDGMALDEVWDSSHFALQ 180
             +G   P   +   +  VL G  V L C    G P P  +W KDG  L            
Sbjct: 763  -TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL------------ 809

Query: 181  PGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240
            P  +     A  +L +  A    +G Y C A N  G       L V  PP   P      
Sbjct: 810  PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI 869

Query: 241  PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
                             NEG  A   C   G P P I W  E   L    R   Y     
Sbjct: 870  ----------------TNEGVPASLPCVASGVPAPTITWTKETNAL--TSRGPHYNVSKE 911

Query: 301  GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK-EPRLRFTR------PLQDVEGR 353
            G +L +    A+D G YVC A N+ G +   ++L V  +PR+          PLQ V  +
Sbjct: 912  GTLL-IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQ-VTAK 969

Query: 354  EHGIAVLECKVPNSRIPTAWFREDQRLLP--CRKYEQIEEGTVRRLIIHRLKADDDGIYL 411
                  L+C+   S  P   + +D R +P    +Y  +  G++R   + +++  D G Y 
Sbjct: 970  AGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLR---LAQVQVGDSGHYE 1026

Query: 412  C 412
            C
Sbjct: 1027 C 1027



 Score =  102 bits (253), Expect = 5e-21
 Identities = 181/704 (25%), Positives = 264/704 (37%), Gaps = 92/704 (13%)

Query: 1047 VLPAAQPEDGG---EFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVE-LR 1102
            +L A++ E+G      V  AG   A   + VT PP ++V     ++     +PG    L 
Sbjct: 366  ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV-----SPGETAVLS 420

Query: 1103 CEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH---- 1157
            C V   A   + W +D   + AS      A+    +L +    P D G Y C   +    
Sbjct: 421  CRVLGEAPYNLTWVRDWRVLPASTGRV--AQLADLSLEISGIIPTDGGRYQCVASNANGV 478

Query: 1158 -EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQE 1215
              A  + ++   P V   ++ T+      + G  V +SC  S    P + WS   + +QE
Sbjct: 479  TRASVWLLVREAPQV---SIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQALQE 533

Query: 1216 GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAA 1275
               + + A+G    L IQ   P  AG Y+CQ+    G    + T+   +PP    +  A 
Sbjct: 534  DSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP----SVSAV 586

Query: 1276 QTRVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
               V    G +  LV   SG   P V WY+ G  +     +   +  +   LR+  A+  
Sbjct: 587  NAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQER 641

Query: 1335 DAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPL----TVHEGDDATFRCEVSP-PDAD 1389
            DAG Y C A  +  +   S E  L V    +LT L    TV  G  A   C  +  P   
Sbjct: 642  DAGTYTCRAVNE--LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT 699

Query: 1390 VTWLRNGAVVTPGPQVEMAQNGSSR-----ILTLRGCQLGDAGTVTLRA----GSTATSA 1440
            VTW R G     G ++   +   SR     +L        D       A    G     A
Sbjct: 700  VTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEA 758

Query: 1441 RLHVR-ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMA 1499
            RL V              VR  EGQ V L              W++ G+PLP  SR S+ 
Sbjct: 759  RLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIR 818

Query: 1500 QDGHIHRLFIHGVILADQGTYGC-------ESHHDRTLARLSVRPRQLRVLRPLEDVTIS 1552
             DG +H   +   +    G Y C         H D  L  + V PR    + P     I+
Sbjct: 819  ADGSLH---LDRALQEHAGRYSCVATNTAGSQHRDVELV-VQVPPR----IHPTATHHIT 870

Query: 1553 EGGSATFQLELSQEGV---TGEWARGGVQLYP-GPKCHIHSDGHRHRLVLNGLGLADSGC 1608
              G     L     GV   T  W +    L   GP  ++  +G    L++      D+G 
Sbjct: 871  NEG-VPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLIAQPSAQDAGA 926

Query: 1609 VSFTADSL----RCAARLIVREVPVTIVRGPHD----LEVT--EGDTATFECELSQALAD 1658
               TA +         RL V   P   + G  +    L+VT   G+  T +CE   +   
Sbjct: 927  YVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP 986

Query: 1659 -VTWEKDGNALTP-SPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
             VTW KD   + P + R  L   G+ RL Q++     D+G Y C
Sbjct: 987  LVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQ---VGDSGHYEC 1027



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 92/318 (28%), Positives = 118/318 (37%), Gaps = 50/318 (15%)

Query: 10   SPPCFLRFPRPVRVVSGAEAELKCVVL-GEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
            +PP        VRV+ G    L C+VL G P P   W K G+ L    R S  ADG+ H 
Sbjct: 766  APPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH- 824

Query: 69   LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
              L  AL   AG Y C A N AG  +    + V  PP   P                 A 
Sbjct: 825  --LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPT----------------AT 866

Query: 129  VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
              +T         G    L C A G+P PT+ W K+  AL       H+ +    +++G 
Sbjct: 867  HHITN-------EGVPASLPCVASGVPAPTITWTKETNALTS--RGPHYNV----SKEG- 912

Query: 189  GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
                 L I      D+G YVC A N  G +     L V+  P         A  P+    
Sbjct: 913  ----TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTA 968

Query: 249  KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
            K          G+     C   G P P + W  + RP+ P   R  Y     G  L++  
Sbjct: 969  KA---------GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR--YGLLPSGS-LRLAQ 1016

Query: 309  CQAKDRGLYVCAARNSAG 326
             Q  D G Y C A N AG
Sbjct: 1017 VQVGDSGHYECTASNPAG 1034



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 172/753 (22%), Positives = 251/753 (33%), Gaps = 132/753 (17%)

Query: 74   ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
            A   + G Y C A + AG   A A + V +PP   P+L PA     SPG           
Sbjct: 369  ASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP---PQLVPAPNVTVSPGE---------- 415

Query: 134  PRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLA 193
                        VL+CR  G     L W +D   L             GR      A L+
Sbjct: 416  ----------TAVLSCRVLGEAPYNLTWVRDWRVL---------PASTGRV--AQLADLS 454

Query: 194  LRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPK 253
            L I      D G Y C A NA+G  +A   L V + P+                +     
Sbjct: 455  LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----------------VSIHTS 498

Query: 254  TFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKD 313
            +   ++G   K  C   G P P I W  E + L  D R  ++ D  G  +++ +    +D
Sbjct: 499  SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQGTLIIQGV--APED 554

Query: 314  RGLYVCAARNSAGQTLSAVQLHVKE-PRLRFTRPLQDVEGREHGIAVLECK-VPNSRIPT 371
             G Y C A N  G     V L+  + P +     +  V   E  + V E   VP  R+  
Sbjct: 555  AGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV-- 612

Query: 372  AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC----EMRGRVRTVANVTVK 427
             W+R    ++        E  +  +L I   +  D G Y C    E+      +      
Sbjct: 613  IWYRGGLEMILAP-----EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH 667

Query: 428  GPILKRLPRKLDVLEGENAVLLVE-TLEAGVEGRWSR-DGEELPVICQSSSGHMH----- 480
             P L  LPR + V  G +A+L    T        W R DG+ L +   +  G        
Sbjct: 668  APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 727

Query: 481  -ALVLPGVTREDAGEVTFSLGN--SRTTTLLRVKCVKHSPP---GPPILAEMFKGHKNTV 534
              L    V  ED         N   +     R+    H+PP          + +G   ++
Sbjct: 728  GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 787

Query: 535  LLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICT 594
                    P PE  ++        GS       SI   G++ +        G Y      
Sbjct: 788  PCIVLAGRPLPERHWLKDGRPLPPGSR-----HSIRADGSLHLDRALQEHAGRYSCVATN 842

Query: 595  VSG-HGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG------TW 647
             +G   R   +V      + PTA      E V             L  +  G      TW
Sbjct: 843  TAGSQHRDVELVVQVPPRIHPTATHHITNEGVPA----------SLPCVASGVPAPTITW 892

Query: 648  FLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGA-------LVGFSCP 700
                  L S  P          Y + ++G    L++     QD+GA        VGFS  
Sbjct: 893  TKETNALTSRGP---------HYNVSKEG---TLLIAQPSAQDAGAYVCTATNTVGFS-- 938

Query: 701  GVQDSAALTIQESP-VHILSPQDR---VSLTFTTSERVVLTCELSRVDFP-ATWYKDGQK 755
                   L++   P +H+   ++    + +T    E V L CE      P  TW KD + 
Sbjct: 939  --SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRP 996

Query: 756  VEESELLVVKMDGRKHRLILPEAKVQDSGEFEC 788
            V         +     R  L + +V DSG +EC
Sbjct: 997  VPPITNRYGLLPSGSLR--LAQVQVGDSGHYEC 1027



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 177/722 (24%), Positives = 263/722 (36%), Gaps = 90/722 (12%)

Query: 196  ILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTF 255
            IL A   + G Y C A +  G  +A A + V  PP      P   PAP V          
Sbjct: 366  ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP------PQLVPAPNVT--------- 410

Query: 256  WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRG 315
             V+ G+ A   C V+G+    + W  + R L     R+    +     L++      D G
Sbjct: 411  -VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA---QLADLSLEISGIIPTDGG 466

Query: 316  LYVCAARNSAGQTLSAVQLHVKE-PRLRFTRPLQDV-EGREHGIAVLECKVPNSRIPTAW 373
             Y C A N+ G T ++V L V+E P++      Q   +G E  ++      P   I  +W
Sbjct: 467  RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI--SW 524

Query: 374  FREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRV----RTVANVTVKGP 429
             RE Q L    +     +GT   LII  +  +D G Y C+    V     TV       P
Sbjct: 525  SRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581

Query: 430  ILKRLPRKLDVLEGENAVLLVETLEAGVEGR---WSRDGEELPVICQSSSGHMHALVLPG 486
             +  +   + V  GE AVL+ E   +GV      W R G E+ +  + SS     L +P 
Sbjct: 582  SVSAVNAVVLVAVGEEAVLVCEA--SGVPPPRVIWYRGGLEMILAPEGSSS--GKLRIPA 637

Query: 487  VTREDAGEVTFSLGNSRTTTLLRVK-CVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
                DAG  T    N        ++  V H+P    +  ++      + LL  +     P
Sbjct: 638  AQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPP 697

Query: 546  ETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV- 604
             T    R + Q +G           + GA        P  G   F   +V+   ++P+V 
Sbjct: 698  PTVTWRRGDGQPLGL----------RLGAGRGSRSRQPDSGVLFFE--SVAPEDQAPYVC 745

Query: 605  -VFHGSAHLVPTARL-VAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNE--PE 660
               +    +   ARL V G    Q+      V  L+   +      L G  L       +
Sbjct: 746  EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805

Query: 661  GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQD-SAALTIQESPVHILS 719
            G+  P   R+ I   G  H L     +H    + V  +  G Q     L +Q  P     
Sbjct: 806  GRPLPPGSRHSIRADGSLH-LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP----- 859

Query: 720  PQDRVSLTFT---TSERV--VLTCELSRVDFPA-TWYKDGQKV-EESELLVVKMDGRKHR 772
               R+  T T   T+E V   L C  S V  P  TW K+   +        V  +G    
Sbjct: 860  ---RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---T 913

Query: 773  LILPEAKVQDSGEFECRTEGVSAFFGVTVQ-----DPPVHIVDPRE---HVFVHAITSEC 824
            L++ +   QD+G + C       F    ++      P +H+   R     + V A   E 
Sbjct: 914  LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEE 973

Query: 825  VMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEG--PHRRLVLPATQPSDGGEFQCVA 881
            V L CE      P V W KD + V      +    G  P   L L   Q  D G ++C A
Sbjct: 974  VTLDCEAKGSPPPLVTWTKDSRPVPP----ITNRYGLLPSGSLRLAQVQVGDSGHYECTA 1029

Query: 882  GD 883
             +
Sbjct: 1030 SN 1031



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 184/770 (23%), Positives = 272/770 (35%), Gaps = 120/770 (15%)

Query: 1186 APGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHA----EGPRRVLCIQAAGPAHAG 1241
            APG   + S EL+++    + +   +P+  G   +L        P+    ++  G  H G
Sbjct: 235  APGR--LDSVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEG 292

Query: 1242 LYTCQ------SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG 1295
                +      SG APGAP +S   ++      +  P      V S     L+L      
Sbjct: 293  NPLLRVSGVSYSGVAPGAPLVSMAPRIHG---YLHQPLLVSCSVHSALPFRLQL------ 343

Query: 1296 PGGPVRWYKDGE-RLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRI----- 1349
                    + GE RL  +   Q     + ++LR   A   + G Y C A   +       
Sbjct: 344  --------RRGEARLGEERHFQESGNSSWEILR---ASKAEEGTYECTAVSRAGTGRAKA 392

Query: 1350 -FLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEM 1407
              +V+   P LV   +    +TV  G+ A   C V      ++TW+R+  V+ P     +
Sbjct: 393  QIVVTDPPPQLVPAPN----VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL-PASTGRV 447

Query: 1408 AQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRETELLFLRRLQDVRAEEG 1463
            AQ      L + G    D G     A    G T  S  L VRE   + +           
Sbjct: 448  AQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ---HFS 503

Query: 1464 QDVCLEVETGRVG-AAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGC 1522
            Q V ++V     G     + W R  Q L  DSR+ +   G    L I GV   D G Y C
Sbjct: 504  QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSC 560

Query: 1523 ESHHD-----RTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE---WAR 1574
            ++ ++      T+      P  +  +  +  V ++ G  A    E S  GV      W R
Sbjct: 561  QATNEVGTDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEAS--GVPPPRVIWYR 616

Query: 1575 GGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTA----DSLRCAARLIVREVPVT 1630
            GG+++   P+    S G   +L +      D+G  +  A           +L V   P  
Sbjct: 617  GGLEMILAPEGS--SSG---KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAP-Q 670

Query: 1631 IVRGPHDLEVTEGDTATFECELS-QALADVTWEK-DGNALTPSPRLRLQA-LGTRR---- 1683
            +   P D+ V  G +A   C  + +    VTW + DG  L     LRL A  G+R     
Sbjct: 671  LTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLG----LRLGAGRGSRSRQPD 726

Query: 1684 --LLQLRRCGPSDAGTYSCAV----GTARAGPVRLTVRERTVAVLSELRSVSAREGDGAT 1737
              +L      P D   Y C      G  +A    +        + S   +V   EG   +
Sbjct: 727  SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 786

Query: 1738 FECTVSEVETTGR------WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ 1791
              C V      GR      W   GRPL PG+R  IR +G  H   L     E AG     
Sbjct: 787  LPCIV----LAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH---LDRALQEHAGRYSCV 839

Query: 1792 AGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSG---GHVCWLRE-GAE 1847
            A         +VE +     R  P     +        +    SG     + W +E  A 
Sbjct: 840  ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNAL 899

Query: 1848 LCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA----GQDSTHTRLLV 1893
               G  Y +   G   +L+I     +D G Y C A    G  S   RL V
Sbjct: 900  TSRGPHYNVSKEG---TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 64/231 (27%), Positives = 88/231 (38%), Gaps = 38/231 (16%)

Query: 26   GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 85
            G  A L CV  G P P + W K  +  A + R        E  LL+      DAG YVC 
Sbjct: 873  GVPASLPCVASGVPAPTITWTK--ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCT 930

Query: 86   ARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEV 145
            A N  G +     ++V   P          R   +       P+ +T         G EV
Sbjct: 931  ATNTVGFSSQEMRLSVNTKP----------RIHMNGSRNANVPLQVTAKA------GEEV 974

Query: 146  VLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSG 205
             L C A G P P + W KD   +  +  ++ + L P         S +LR+   ++ DSG
Sbjct: 975  TLDCEAKGSPPPLVTWTKDSRPVPPI--TNRYGLLP---------SGSLRLAQVQVGDSG 1023

Query: 206  VYVCHARNAHGHAQAGALLQVH-----QPPESP----PADPDEAPAPVVEP 247
             Y C A N  G A    +L V      QP   P    PA       P+++P
Sbjct: 1024 HYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQP 1074



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 132/527 (25%), Positives = 191/527 (36%), Gaps = 80/527 (15%)

Query: 678  QHRLILHAVKHQDSGALVGFSCPGVQ----DSAALTIQESPVHILSPQDRVSLTFTTSER 733
            Q  LI+  V  +D+G    +SC        D   +T+  +    +S  + V L     E 
Sbjct: 542  QGTLIIQGVAPEDAG---NYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV-AVGEE 597

Query: 734  VVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
             VL CE S V  P   WY+ G      E+++        +L +P A+ +D+G + CR   
Sbjct: 598  AVLVCEASGVPPPRVIWYRGGL-----EMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652

Query: 793  ----VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYK-DGQE 846
                 SA   + V   P     PR+   V        +LAC       P V W + DGQ 
Sbjct: 653  ELGDASAEIQLAVGHAPQLTELPRD---VTVELGRSALLACRATGRPPPTVTWRRGDGQP 709

Query: 847  VEESDFVVLENEGPHRR------LVLPATQPSDGGEFQC----VAGDECAYFTVTITDVS 896
            +      +    G   R      L   +  P D   + C    V G   A   + +T  +
Sbjct: 710  L---GLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA 766

Query: 897  SWIVYPSGKVYVAAVRLERVVLTCELC--RPWAEVRWTKDGEEVVESPALLLQKEDTVRR 954
               +  S    V  +  + V L C +   RP  E  W KDG  +       ++ + +   
Sbjct: 767  PPQIASSAPT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS--- 822

Query: 955  LVLPAVQLEDSGEYLCEIDDESAS----FTVTVTEPPVRIIYPRDEVTLIAVTLECV--V 1008
            L L     E +G Y C   + + S      + V  PP   I+P        +T E V   
Sbjct: 823  LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP--RIHP---TATHHITNEGVPAS 877

Query: 1009 LMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRL----VLPAAQP--EDGGEFVC 1061
            L C  S   AP + W K        E   L   GP   +     L  AQP  +D G +VC
Sbjct: 878  LPCVASGVPAPTITWTK--------ETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 929

Query: 1062 DA----GDDSAFFTVTVTAPPERIVHPAARS----LDLHFGAPGRVELRCEVAPAGSQ-V 1112
             A    G  S    ++V   P RI    +R+    L +   A   V L CE   +    V
Sbjct: 930  TATNTVGFSSQEMRLSVNTKP-RIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLV 988

Query: 1113 RWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA 1159
             W KD   V            P+ +L L   Q  D+G Y C   + A
Sbjct: 989  TWTKDSRPV--PPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPA 1033


>gi|133908641 myosin binding protein C, fast type [Homo sapiens]
          Length = 1141

 Score =  125 bits (313), Expect = 5e-28
 Identities = 99/357 (27%), Positives = 153/357 (42%), Gaps = 37/357 (10%)

Query: 1551 ISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVS 1610
            +  G      +E+S   +T +W + G ++ P  K    + G +  L +N   LAD     
Sbjct: 268  VDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYE 327

Query: 1611 FTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTP 1670
                  +C   L V+E PV IV    D +V  GD      E+S+  A V W KDG  LT 
Sbjct: 328  VAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQVMWMKDGVELTR 387

Query: 1671 ----SPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELR 1726
                  R R +  G R +L        D G Y       +     L V E+ + VL ++ 
Sbjct: 388  EDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQC-EAELIVEEKQLEVLQDIA 446

Query: 1727 SVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG 1786
             ++ +  + A F+C VS+ + TG+W   G  +RP  R+ I   G+ H LV+ ++R ED G
Sbjct: 447  DLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEG 506

Query: 1787 EVRF-QAGPAQSLAL------LEVEALPLQM-------CRHPPREKTVLV--GRRAVLEV 1830
            +  F   G A SL+       ++VE +P Q        C     E  ++V  G +  L+V
Sbjct: 507  DYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSENAIVVVAGNKLRLDV 566

Query: 1831 TVSRSGGHVC-WLREGAELCPGDKYEMRSHGPTH--------SLVIHDVRPEDQGTY 1878
            +++     V  WL+       GD+    + G T         S VI   + ED+G Y
Sbjct: 567  SITGEPPPVATWLK-------GDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGRY 616



 Score =  121 bits (304), Expect = 6e-27
 Identities = 79/268 (29%), Positives = 124/268 (46%), Gaps = 8/268 (2%)

Query: 1371 VHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVT 1430
            V  G+      E+S PD  + W +NG  + P  +      G  RILT+  C L D     
Sbjct: 268  VDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYE 327

Query: 1431 LRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPL 1490
            +          L V+E  +L +  L+D +   G  V + VE    GA   V W++ G  L
Sbjct: 328  VAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQ--VMWMKDGVEL 385

Query: 1491 PHD----SRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPL 1546
              +    +R    +DG  H L    V+  D+G Y   ++  +  A L V  +QL VL+ +
Sbjct: 386  TREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEEKQLEVLQDI 445

Query: 1547 EDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADS 1606
             D+T+     A F+ E+S E VTG+W + GV++ P  +  I   G  H+LV++ +   D 
Sbjct: 446  ADLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDE 505

Query: 1607 GCVSFTAD--SLRCAARLIVREVPVTIV 1632
            G  +F  D  +L  +A+L   E+ V  V
Sbjct: 506  GDYTFVPDGYALSLSAKLNFLEIKVEYV 533



 Score = 97.8 bits (242), Expect = 9e-20
 Identities = 71/244 (29%), Positives = 109/244 (44%), Gaps = 6/244 (2%)

Query: 1639 EVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            +V  G+      E+S     + W K+G  + PS +   + +G +R+L + +C  +D   Y
Sbjct: 267  QVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAY 326

Query: 1699 SCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPL 1758
              AV   +     L V+E  V +++ L       GD       VSE      W   G  L
Sbjct: 327  EVAVKDEKCF-TELFVKEPPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQVMWMKDGVEL 385

Query: 1759 RP----GARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHP 1814
                   AR R +++GK+HIL+ S++  ED G  +      Q  A L VE   L++ +  
Sbjct: 386  TREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEEKQLEVLQ-D 444

Query: 1815 PREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPED 1874
              + TV    +AV +  VS       W + G E+ P  +  +   G  H LVI DVRPED
Sbjct: 445  IADLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPED 504

Query: 1875 QGTY 1878
            +G Y
Sbjct: 505  EGDY 508



 Score = 95.1 bits (235), Expect = 6e-19
 Identities = 100/410 (24%), Positives = 166/410 (40%), Gaps = 46/410 (11%)

Query: 702  VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESEL 761
            V+ SAA T +  P + +   DR         ++ L  E+S  D    W+K+GQ+++ S  
Sbjct: 252  VKKSAAFTKKLDPAYQV---DR-------GNKIKLMVEISDPDLTLKWFKNGQEIKPSSK 301

Query: 762  LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPRE--HVFVHA 819
             V +  G+K  L + +  + D   +E   +    F  + V++PPV IV P E   VFV  
Sbjct: 302  YVFENVGKKRILTINKCTLADDAAYEVAVKDEKCFTELFVKEPPVLIVTPLEDQQVFV-- 359

Query: 820  ITSECVMLACEVDREDAPVRWYKDGQEVEESDFVV----LENEGPHRRLVLPATQPSDGG 875
               + V +A EV  E A V W KDG E+   D        + +G    L+       D G
Sbjct: 360  --GDRVEMAVEVSEEGAQVMWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRG 417

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDG 935
             +Q +         + + +    ++     + V A   E+ V  CE+       +W K+G
Sbjct: 418  RYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKA--SEQAVFKCEVSDEKVTGKWYKNG 475

Query: 936  EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIY-PR 994
             EV  S  + +       +LV+  V+ ED G+Y    D  + S +  +    +++ Y P+
Sbjct: 476  VEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPK 535

Query: 995  DEV--------------TLIAVTLECVVLMCELSREDAPVRWYKDGLEV--EESEALVLE 1038
             E                ++ V    + L   ++ E  PV  +  G EV         +E
Sbjct: 536  QEPPKIHLDCSGKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIE 595

Query: 1039 RDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFF---TVTVTAPPERI 1081
            +       V+ +AQ ED G +        G+D A      V V  PPE +
Sbjct: 596  KRVDCSSFVIESAQREDEGRYTIKVTNPVGEDVASIFLQVVDVPDPPEAV 645



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 88/351 (25%), Positives = 138/351 (39%), Gaps = 26/351 (7%)

Query: 1007 VVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDD 1066
            + LM E+S  D  ++W+K+G E++ S   V E  G +  L +      D   +     D+
Sbjct: 274  IKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVKDE 333

Query: 1067 SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDA 1126
              F  + V  PP  IV P     D       RVE+  EV+  G+QV W KDG+E+   D+
Sbjct: 334  KCFTELFVKEPPVLIVTPLE---DQQVFVGDRVEMAVEVSEEGAQVMWMKDGVELTREDS 390

Query: 1127 L----QLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSP 1182
                 +   +G    L       ED G Y   T        +I+ E  ++ L      + 
Sbjct: 391  FKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEEKQLEVL---QDIAD 447

Query: 1183 LCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGL 1242
            L V   E  V  CE+S       W  NG  V+  + + +   G    L I    P   G 
Sbjct: 448  LTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGD 507

Query: 1243 YTCQSGAAPGAPSLSFTVQVAEPPVRVV------------APEAAQTRVRSTPGGDLELV 1290
            YT        A SLS  +   E  V  V            + + ++  +    G  L L 
Sbjct: 508  YTFVPDGY--ALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSENAIVVVAGNKLRLD 565

Query: 1291 VHLSGPGGPVRWYKDGERL--ASQGRVQLEQAGARQVLRVQGARSGDAGEY 1339
            V ++G   PV  +  G+ +   ++GR ++E+        ++ A+  D G Y
Sbjct: 566  VSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGRY 616



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 95/407 (23%), Positives = 163/407 (40%), Gaps = 52/407 (12%)

Query: 647  WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSA 706
            WF NG+E+K +           +Y  E  G +  L ++     D  A        V+D  
Sbjct: 289  WFKNGQEIKPSS----------KYVFENVGKKRILTINKCTLADDAAYE----VAVKDEK 334

Query: 707  ALT---IQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLV 763
              T   ++E PV I++P +   +     +RV +  E+S       W KDG ++   +   
Sbjct: 335  CFTELFVKEPPVLIVTPLEDQQVF--VGDRVEMAVEVSEEGAQVMWMKDGVELTREDSFK 392

Query: 764  V----KMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHA 819
                 K DG++H LI  +   +D G ++  T G      + V++  + ++     + V A
Sbjct: 393  ARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEEKQLEVLQDIADLTVKA 452

Query: 820  ITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC 879
              SE  +  CEV  E    +WYK+G EV  S  + + + G   +LV+   +P D G++  
Sbjct: 453  --SEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTF 510

Query: 880  VAGDECAYFTVTITDVSSWIVYP------------SGK------VYVAAVRLER-VVLTC 920
            V        +  +  +   + Y             SGK      V VA  +L   V +T 
Sbjct: 511  VPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSENAIVVVAGNKLRLDVSITG 570

Query: 921  ELCRPWAEVRWTKDGEEVVESPA--LLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESAS 978
            E   P     W K G+EV  +      ++K       V+ + Q ED G Y  ++ +    
Sbjct: 571  E---PPPVATWLK-GDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGRYTIKVTNPVGE 626

Query: 979  FTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDA--PVRWY 1023
               ++    V +  P + V + +V  +  +L+ E    D   PV  Y
Sbjct: 627  DVASIFLQVVDVPDPPEAVRITSVGEDWAILVWEPPMYDGGKPVTGY 673



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 82/331 (24%), Positives = 136/331 (41%), Gaps = 37/331 (11%)

Query: 614 PTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRI 672
           P   +V  LED QV+ G+    ++++S    Q  W  +G EL   +          RYR 
Sbjct: 344 PPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQVMWMKDGVELTREDSF------KARYRF 397

Query: 673 EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
           ++ G +H LI   V  +D G     +  G Q  A L ++E  + +L  QD   LT   SE
Sbjct: 398 KKDGKRHILIFSDVVQEDRGRYQVITNGG-QCEAELIVEEKQLEVL--QDIADLTVKASE 454

Query: 733 RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
           + V  CE+S       WYK+G +V  S+ + +   GR H+L++ + + +D G++    +G
Sbjct: 455 QAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDG 514

Query: 793 VSA-------FFGVTVQDPPVHIVDPREHVFVHAITSECVM---------LACEVDREDA 836
            +        F  + V+  P     P+ H+     TSE  +         L   +  E  
Sbjct: 515 YALSLSAKLNFLEIKVEYVPKQ-EPPKIHLDCSGKTSENAIVVVAGNKLRLDVSITGEPP 573

Query: 837 PVRWYKDGQEV--EESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTV 890
           PV  +  G EV         +E        V+ + Q  D G +        G++ A   +
Sbjct: 574 PVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGRYTIKVTNPVGEDVASIFL 633

Query: 891 TITDVSSWIVYPSGKVYVAAVRLERVVLTCE 921
            + DV      P   V + +V  +  +L  E
Sbjct: 634 QVVDVPD----PPEAVRITSVGEDWAILVWE 660



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 70/272 (25%), Positives = 109/272 (40%), Gaps = 16/272 (5%)

Query: 1188 GEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQS 1247
            G  + L  E+S     + W  NG+ ++          G +R+L I     A    Y    
Sbjct: 271  GNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYE--- 327

Query: 1248 GAAPGAPSLSFTVQVAEPPVRVVAP-EAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1306
              A         + V EPPV +V P E  Q  V    G  +E+ V +S  G  V W KDG
Sbjct: 328  -VAVKDEKCFTELFVKEPPVLIVTPLEDQQVFV----GDRVEMAVEVSEEGAQVMWMKDG 382

Query: 1307 ERLASQ----GRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKL 1362
              L  +     R + ++ G R +L        D G Y            + VEE  L ++
Sbjct: 383  VELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEEKQL-EV 441

Query: 1363 VSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQ 1422
            + ++  LTV   + A F+CEVS       W +NG  V P  ++ ++  G    L +   +
Sbjct: 442  LQDIADLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVR 501

Query: 1423 LGDAGTVTLRAGSTA--TSARLHVRETELLFL 1452
              D G  T      A   SA+L+  E ++ ++
Sbjct: 502  PEDEGDYTFVPDGYALSLSAKLNFLEIKVEYV 533



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 42/157 (26%), Positives = 69/157 (43%), Gaps = 5/157 (3%)

Query: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALL 1801
            +S+ + T +W   G+ ++P ++      GKK IL +++    D           +    L
Sbjct: 280  ISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVKDEKCFTEL 339

Query: 1802 EVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGD----KYEMR 1857
             V+  P+ +   P  ++ V VG R  + V VS  G  V W+++G EL   D    +Y  +
Sbjct: 340  FVKEPPVLIVT-PLEDQQVFVGDRVEMAVEVSEEGAQVMWMKDGVELTREDSFKARYRFK 398

Query: 1858 SHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
              G  H L+  DV  ED+G Y            L+VE
Sbjct: 399  KDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVE 435



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 52/246 (21%), Positives = 93/246 (37%), Gaps = 14/246 (5%)

Query: 1098 RVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH 1157
            +++L  E++     ++W+K+G E++ S        G  R LT+      D   Y    + 
Sbjct: 273  KIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKRILTINKCTLADDAAYEVAVKD 332

Query: 1158 EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGE 1217
            E     + + EPPV    + T      V  G+ V ++ E+S  GA V+W  +G  +   +
Sbjct: 333  EKCFTELFVKEPPV---LIVTPLEDQQVFVGDRVEMAVEVSEEGAQVMWMKDGVELTRED 389

Query: 1218 GLE----LHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPE 1273
              +       +G R +L          G Y   +        L     + E     V  +
Sbjct: 390  SFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAEL-----IVEEKQLEVLQD 444

Query: 1274 AAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARS 1333
             A   V+++     +  V      G  +WYK+G  +    R+ +   G    L +   R 
Sbjct: 445  IADLTVKASEQAVFKCEVSDEKVTG--KWYKNGVEVRPSKRITISHVGRFHKLVIDDVRP 502

Query: 1334 GDAGEY 1339
             D G+Y
Sbjct: 503  EDEGDY 508



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 61/285 (21%), Positives = 116/285 (40%), Gaps = 42/285 (14%)

Query: 312 KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPT 371
           +DRG Y      + GQ     +L V+E +L   + + D+  +    AV +C+V + ++  
Sbjct: 414 EDRGRYQVIT--NGGQC--EAELIVEEKQLEVLQDIADLTVKASEQAVFKCEVSDEKVTG 469

Query: 372 AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVAN----VTVK 427
            W++    + P ++      G   +L+I  ++ +D+G Y     G   +++     + +K
Sbjct: 470 KWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIK 529

Query: 428 GPIL-KRLPRKLDV----LEGENAVLLVE----TLEAGVEGR------WSRDGE------ 466
              + K+ P K+ +       ENA+++V      L+  + G       W +  E      
Sbjct: 530 VEYVPKQEPPKIHLDCSGKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTE 589

Query: 467 -----ELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPP 521
                E  V C S        V+    RED G  T  + N     +  +       P PP
Sbjct: 590 GRTRIEKRVDCSS-------FVIESAQREDEGRYTIKVTNPVGEDVASIFLQVVDVPDPP 642

Query: 522 ILAEMFKGHKNTVLLTWKPPEPAPETPFI-YRLERQEVGSEDWIQ 565
               +    ++  +L W+PP      P   Y +ER++ GS+ W++
Sbjct: 643 EAVRITSVGEDWAILVWEPPMYDGGKPVTGYLVERKKKGSQRWMK 687



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 30/82 (36%), Positives = 36/82 (43%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
            VV+G  A L C V G P P VVW K   ++    +           L +    P DAG Y
Sbjct: 1059 VVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTY 1118

Query: 83   VCRARNAAGEAYAAAAVTVLEP 104
             CRA N  GEA A   + V  P
Sbjct: 1119 TCRAVNELGEALAECKLEVRVP 1140



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 66/281 (23%), Positives = 110/281 (39%), Gaps = 22/281 (7%)

Query: 255 FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
           + V+ G   K    +   P+  ++W   G+ + P  +  ++ +     +L +  C   D 
Sbjct: 266 YQVDRGNKIKLMVEI-SDPDLTLKWFKNGQEIKPSSK-YVFENVGKKRILTINKCTLADD 323

Query: 315 GLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWF 374
             Y  A ++    T    +L VKEP +    PL+D +        +  +V        W 
Sbjct: 324 AAYEVAVKDEKCFT----ELFVKEPPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQVMWM 379

Query: 375 REDQRLLP----CRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPI 430
           ++   L        +Y   ++G    LI   +  +D G Y     G  +  A + V+   
Sbjct: 380 KDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGG-QCEAELIVEEKQ 438

Query: 431 LKRLP--RKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGHMHALVLP 485
           L+ L     L V   E AV   E  +  V G+W ++G E+     I  S  G  H LV+ 
Sbjct: 439 LEVLQDIADLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKLVID 498

Query: 486 GVTREDAGEVTF-----SLGNSRTTTLLRVKCVKHSPPGPP 521
            V  ED G+ TF     +L  S     L +K V++ P   P
Sbjct: 499 DVRPEDEGDYTFVPDGYALSLSAKLNFLEIK-VEYVPKQEP 538



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 96/415 (23%), Positives = 144/415 (34%), Gaps = 48/415 (11%)

Query: 104 PPASDPELQPAERPLP--SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGG--LPE-PT 158
           PP   P   P E P    SP + E   VFL  P S  V  G + V+  +  G  LP+ PT
Sbjct: 26  PPKEAPAEAPKEAPPEDQSPTAEEPTGVFLKKPDSVSVETGKDAVVVAKVNGKELPDKPT 85

Query: 159 LYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHA 218
           + W K           + F+ +          ++ L I    L D G Y    +      
Sbjct: 86  IKWFKGKWLELGSKSGARFSFKESHNSASNVYTVELHIGKVVLGDRGYYRLEVKAKDTCD 145

Query: 219 QAGALLQVHQPPESPPADPDEA----------PAPVVEPLKCAPKTFWVNEGKHAKFRCY 268
             G  + V  P +       E+           A  ++      K   V E K  K +  
Sbjct: 146 SCGFNIDVEAPRQDASGQSLESFKRTSEKKSDTAGELDFSGLLKKREVVEEEKKKKKKDD 205

Query: 269 V-MGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQ 327
             +G P PEI   WE   LL   ++  Y        +   Y     RG+          +
Sbjct: 206 DDLGIP-PEI---WE---LLKGAKKSEYEK------IAFQYGITDLRGML---------K 243

Query: 328 TLSAVQLHVKEPRLRFTRPLQDVEGREHGIAV-LECKVPNSRIPTAWFREDQRLLPCRKY 386
            L   ++ VK+    FT+ L      + G  + L  ++ +  +   WF+  Q + P  KY
Sbjct: 244 RLKKAKVEVKKSAA-FTKKLDPAYQVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKY 302

Query: 387 EQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLP-RKLDVLEGEN 445
                G  R L I++    DD  Y   ++           + P+L   P     V  G+ 
Sbjct: 303 VFENVGKKRILTINKCTLADDAAYEVAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDR 362

Query: 446 AVLLVETLEAGVEGRWSRDGEELPVICQ-------SSSGHMHALVLPGVTREDAG 493
             + VE  E G +  W +DG EL               G  H L+   V +ED G
Sbjct: 363 VEMAVEVSEEGAQVMWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRG 417



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 26/86 (30%), Positives = 41/86 (47%), Gaps = 5/86 (5%)

Query: 23  VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE---RLSFPADGAEHGLLLTAALPTDA 79
           VV+G +  L   + GEPPPV  W KG +    +E   R+    D +    ++ +A   D 
Sbjct: 556 VVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCS--SFVIESAQREDE 613

Query: 80  GVYVCRARNAAGEAYAAAAVTVLEPP 105
           G Y  +  N  GE  A+  + V++ P
Sbjct: 614 GRYTIKVTNPVGEDVASIFLQVVDVP 639



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 32/103 (31%), Positives = 40/103 (38%), Gaps = 9/103 (8%)

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
            AP FLT    + V+ G    L C   G P+P + W K+ M + E          P     
Sbjct: 1047 APKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIRE---------DPKFLIT 1097

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQP 229
                 L L I      D+G Y C A N  G A A   L+V  P
Sbjct: 1098 NYQGVLTLNIRRPSPFDAGTYTCRAVNELGEALAECKLEVRVP 1140



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 1/81 (1%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G  A   C V G P+P++ W      +  D + L+  +  G   L +      D G Y C
Sbjct: 1062 GYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLI-TNYQGVLTLNIRRPSPFDAGTYTC 1120

Query: 320  AARNSAGQTLSAVQLHVKEPR 340
             A N  G+ L+  +L V+ P+
Sbjct: 1121 RAVNELGEALAECKLEVRVPQ 1141



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 54/217 (24%), Positives = 82/217 (37%), Gaps = 26/217 (11%)

Query: 23  VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
           V +  +A  KC V  E      W K G ++  S+R++    G  H L++    P D G Y
Sbjct: 450 VKASEQAVFKCEVSDEKV-TGKWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDY 508

Query: 83  VCRARNAAGEAYA---AAAVTVLEPPAS-DPELQPAERPLPSPGSGEGAPVFLTGPRSQW 138
                    + YA   +A +  LE      P+ +P +  L   G         T   +  
Sbjct: 509 -----TFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGK--------TSENAIV 555

Query: 139 VLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILA 198
           V+ G ++ L     G P P   W K     DEV+ ++    +  +  D      +  I +
Sbjct: 556 VVAGNKLRLDVSITGEPPPVATWLKG----DEVFTTTEGRTRIEKRVD----CSSFVIES 607

Query: 199 ARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPA 235
           A+  D G Y     N  G   A   LQV   P+ P A
Sbjct: 608 AQREDEGRYTIKVTNPVGEDVASIFLQVVDVPDPPEA 644



 Score = 31.6 bits (70), Expect = 7.7
 Identities = 19/65 (29%), Positives = 27/65 (41%), Gaps = 1/65 (1%)

Query: 1637 DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
            D  V  G +A   C +       V W K+   +   P+  +        L +RR  P DA
Sbjct: 1056 DRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDA 1115

Query: 1696 GTYSC 1700
            GTY+C
Sbjct: 1116 GTYTC 1120


>gi|148596957 myosin binding protein C, cardiac [Homo sapiens]
          Length = 1274

 Score =  124 bits (312), Expect = 7e-28
 Identities = 160/671 (23%), Positives = 246/671 (36%), Gaps = 105/671 (15%)

Query: 1008 VLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDS 1067
            V   E  R    VRW + G ++  S    L  +G R  L +    P D G +   AG   
Sbjct: 28   VFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSK 87

Query: 1068 AFFTVTV--TAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASD 1125
              F + V      E ++ PA    +   GAPG  E     A  G      K      +S 
Sbjct: 88   VKFDLKVIEAEKAEPMLAPAPAPAEAT-GAPG--EAPAPAAELGESAPSPKGS----SSA 140

Query: 1126 ALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCV 1185
            AL     GPT     P A  +  G +V   +   +T                        
Sbjct: 141  ALN----GPT-----PGAPDDPIGLFVMRPQDGEVTV----------------------- 168

Query: 1186 APGEPVVLSCELSRAGA---PVVWSHNGRPV----QEGEGLELHAEGPRRV------LCI 1232
              G  +  S  ++ A     PVV    G+ V    + G+ L+LH    R        L I
Sbjct: 169  --GGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHI 226

Query: 1233 QAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELV-- 1290
              A PA  G Y C+          +F + V E                +   GDL+L+  
Sbjct: 227  TDAQPAFTGSYRCEVSTKDKFDCSNFNLTVHE----------------AMGTGDLDLLSA 270

Query: 1291 ---VHLSGPGGPVRWYKDGERLASQGRVQLEQAGAR--QVLRVQGARSGDAGEYLCDAPQ 1345
                 L+G G  +    +   +     +  ++   R  +  +++     D  E L  AP 
Sbjct: 271  FRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPP 330

Query: 1346 DS------------------RIFLVSVEEPLLVKLVSELTPL-TVHEGDDATFRCEVSPP 1386
                                R+  +  +E        +L P   V +G       E++  
Sbjct: 331  SEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADH 390

Query: 1387 DADVTWLRNGAVVT-PGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
            DA+V WL+NG  +   G +      G+ R LT+  C L D        G    S  L V+
Sbjct: 391  DAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVK 450

Query: 1446 ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDS--RLSMAQDGH 1503
            E  +L  R L+D     GQ V  E E    GA   V+W++ G  L  +   +    +DG 
Sbjct: 451  EPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQ--VKWLKDGVELTREETFKYRFKKDGQ 508

Query: 1504 IHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLEL 1563
             H L I+  +L D G Y   +   + LA L V+ ++L V + + D+ +     A F+ E+
Sbjct: 509  RHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKCEV 568

Query: 1564 SQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRC--AAR 1621
            S E V G W + G +L P  +  +   G  H+L ++ +  AD    SF  +   C  +A+
Sbjct: 569  SDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAK 628

Query: 1622 LIVREVPVTIV 1632
            L   EV +  V
Sbjct: 629  LHFMEVKIDFV 639



 Score =  122 bits (307), Expect = 3e-27
 Identities = 162/649 (24%), Positives = 247/649 (38%), Gaps = 86/649 (13%)

Query: 1087 RSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPE 1146
            RS+++  G+P   E   E   AG +VRW + G ++ AS+   L  EG   TLT+    P 
Sbjct: 17   RSVEVAAGSPAVFE--AETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPA 74

Query: 1147 DAGEYVCETRHEAITFN--VILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV 1204
            D G Y        + F+  VI AE     LA    P+P   AP E           GAP 
Sbjct: 75   DQGSYAVIAGSSKVKFDLKVIEAEKAEPMLA----PAP---APAEAT---------GAP- 117

Query: 1205 VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
                 G        L   A  P+        G + A L    +G  PGAP     + V  
Sbjct: 118  -----GEAPAPAAELGESAPSPK--------GSSSAAL----NGPTPGAPDDPIGLFVMR 160

Query: 1265 PPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG----GPVRWYKDGERLASQGRV----Q 1316
            P    V           T GG +     ++G        V+W+K G+ +    +V    Q
Sbjct: 161  PQDGEV-----------TVGGSITFSARVAGASLLKPPVVKWFK-GKWVDLSSKVGQHLQ 208

Query: 1317 LEQAGARQV------LRVQGARSGDAGEYLCDAPQDSRI----FLVSVEEPLL---VKLV 1363
            L  +  R        L +  A+    G Y C+     +     F ++V E +    + L+
Sbjct: 209  LHDSYDRASKVYLFELHITDAQPAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLL 268

Query: 1364 SELTPLTVHEGDDATFRCEVSPPDADVTWL--RNGAVVTPGPQVEMAQNGSSRILTLRGC 1421
            S     ++  G              D + L  +  +  TP      A         LR  
Sbjct: 269  SAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQA 328

Query: 1422 QLGDAGTVTLRAGSTATSARLH----VRETE---LLFLRRLQDV-RAEEGQDVCLEVETG 1473
               +   +  + G T     L     +R  E     F ++L+   +  +G  + L VE  
Sbjct: 329  PPSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELA 388

Query: 1474 RVGAAGAVRWVRGGQPLPHD-SRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLAR 1532
               A   V+W++ GQ +    S+      G    L I    LAD   Y C    ++    
Sbjct: 389  DHDAE--VKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTE 446

Query: 1533 LSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGP--KCHIHSD 1590
            L V+   + + RPLED  +  G    F+ E+S+EG   +W + GV+L      K     D
Sbjct: 447  LFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKD 506

Query: 1591 GHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFEC 1650
            G RH L++N   L D+G  +      +  A LIV+E  + + +   DL V   D A F+C
Sbjct: 507  GQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKC 566

Query: 1651 ELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYS 1699
            E+S       W K+G  L P  R+++  +G    L +    P+D   YS
Sbjct: 567  EVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYS 615



 Score =  107 bits (267), Expect = 1e-22
 Identities = 212/928 (22%), Positives = 332/928 (35%), Gaps = 163/928 (17%)

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPA-LLLQKEDTVRRLVLPAVQLEDSGEYLCEID 973
            ++ LT EL    AEV+W K+G+E+  S +  + +     R L +    L D   Y C + 
Sbjct: 380  KIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVG 439

Query: 974  DESASFTVTVTEPPVRIIYP-RDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEV--E 1030
             E  S  + V EPPV I  P  D++ ++   +E     CE+S E A V+W KDG+E+  E
Sbjct: 440  GEKCSTELFVKEPPVLITRPLEDQLVMVGQRVE---FECEVSEEGAQVKWLKDGVELTRE 496

Query: 1031 ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLD 1090
            E+     ++DG R  L++  A  ED G +        A   + V      +    A   D
Sbjct: 497  ETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIA---D 553

Query: 1091 LHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE 1150
            L  GA  +   +CEV+    +  W K+G E+     +++   G    LT+    P D  +
Sbjct: 554  LMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEAD 613

Query: 1151 YVCETRHEAITFNVIL------------AEPP-VQFLALETTPSPLCVAPGEPVVLSCEL 1197
            Y       A   +  L             EPP +        P  + V  G  + L   +
Sbjct: 614  YSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPI 673

Query: 1198 SRAGAPVV-----------------------------WSHNGRPVQEGEG-LELHAEGPR 1227
            S   AP V                             W  + + + E EG + +     R
Sbjct: 674  SGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDR 733

Query: 1228 RVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDL 1287
             +  ++ A     G+YT       G   ++ TV+V + P    AP+ +         G+ 
Sbjct: 734  SIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNV-------GED 786

Query: 1288 ELVVHLSGP----GGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA 1343
               V    P    G P+  Y    +     R         Q L  +  R  +   Y    
Sbjct: 787  SCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVY---- 842

Query: 1344 PQDSRIFLVS---------VEEPLL-VKLVSELTPLTVHEGDDATFRCEVSPPDADVTWL 1393
              + R++ V+           +P + +   SE T L V +  D T   +  PP+      
Sbjct: 843  --EMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVSLKWRPPE------ 894

Query: 1394 RNGAVVTPGPQVEMAQNGSSR-ILTLRGCQLGDAGTVTLRAGSTATSARLHVRE------ 1446
            R GA    G  VE    G S  +  L+G  L +  ++ ++   T       VR       
Sbjct: 895  RVGAGGLDGYSVEYCPEGCSEWVAALQG--LTEHTSILVKDLPTGARLLFRVRAHNMAGP 952

Query: 1447 ------------TELLFLRRL-------QDVRAEEGQDVCLEVETGRVGAAGAVRWVRGG 1487
                         E+L   RL       Q ++ + G+ V L +   +      V W + G
Sbjct: 953  GAPVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPF-QGKPRPQVTWTKEG 1011

Query: 1488 QPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY----GCESHHDRTLARLSV-----RPR 1538
            QPL  +  +S+        LFI        GTY      E+  D+    L V      P+
Sbjct: 1012 QPLAGE-EVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQ 1070

Query: 1539 QLRVL-----------RPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKC-- 1585
             LRV            +P +DV  +E    T Q     +  T EW    ++ Y    C  
Sbjct: 1071 DLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQ---KADKKTMEWFT-VLEHYRRTHCVV 1126

Query: 1586 --HIHSDGHRHRLV-LNGLGLADSGCVSFTADSLRCAARLIVREVP----VTIVRGPH-- 1636
               I  +G+  R+   N +G +D      T + +      I  E P    +     P   
Sbjct: 1127 PELIIGNGYYFRVFSQNMVGFSDRAAT--TKEPVFIPRPGITYEPPNYKALDFSEAPSFT 1184

Query: 1637 ----DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCG 1691
                +  V  G TA   C +       ++W K+G  L    R R+ +      L++R+  
Sbjct: 1185 QPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPC 1244

Query: 1692 PSDAGTYSCAV----GTARAGPVRLTVR 1715
            P D G Y C      G AR    RL VR
Sbjct: 1245 PFDGGIYVCRATNLQGEARC-ECRLEVR 1271



 Score =  103 bits (256), Expect = 2e-21
 Identities = 68/243 (27%), Positives = 106/243 (43%), Gaps = 4/243 (1%)

Query: 1551 ISEGGSATFQLELSQEGVTGEWARGGVQLY-PGPKCHIHSDGHRHRLVLNGLGLADSGCV 1609
            +S+G      +EL+      +W + G ++   G K    S G +  L ++   LAD    
Sbjct: 375  VSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAY 434

Query: 1610 SFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALT 1669
                   +C+  L V+E PV I R   D  V  G    FECE+S+  A V W KDG  LT
Sbjct: 435  QCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELT 494

Query: 1670 PSP--RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRS 1727
                 + R +  G R  L +      DAG Y+      +A    L V+E+ + V   +  
Sbjct: 495  REETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQA-LAELIVQEKKLEVYQSIAD 553

Query: 1728 VSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE 1787
            +     D A F+C VS+    G W   G+ L P +R+++   G+ H L + ++   D  +
Sbjct: 554  LMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEAD 613

Query: 1788 VRF 1790
              F
Sbjct: 614  YSF 616



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 70/245 (28%), Positives = 112/245 (45%), Gaps = 9/245 (3%)

Query: 1639 EVTEGDTATFECELSQALADVTWEKDGNALTPS-PRLRLQALGTRRLLQLRRCGPSDAGT 1697
            +V++G       EL+   A+V W K+G  +  S  +   +++G +R L + +C  +D   
Sbjct: 374  QVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAA 433

Query: 1698 YSCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRP 1757
            Y C VG  +     L V+E  V +   L       G    FEC VSE     +W   G  
Sbjct: 434  YQCVVGGEKCS-TELFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVE 492

Query: 1758 L--RPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPP 1815
            L      + R +++G++H L+++E   EDAG         Q+LA L V+   L++ +   
Sbjct: 493  LTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIA 552

Query: 1816 REKTVLVGRR--AVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE 1873
                ++VG +  AV +  VS       WL+ G EL P  + ++   G  H L I DV P 
Sbjct: 553  ---DLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPA 609

Query: 1874 DQGTY 1878
            D+  Y
Sbjct: 610  DEADY 614



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 77/276 (27%), Positives = 119/276 (43%), Gaps = 15/276 (5%)

Query: 1185 VAPGEPVVLSCELSRAGAPVVWSHNGRPVQ-EGEGLELHAEGPRRVLCIQAAGPAHAGLY 1243
            V+ G  + L+ EL+   A V W  NG+ +Q  G      + G +R L I     A    Y
Sbjct: 375  VSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAY 434

Query: 1244 TCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWY 1303
             C      G    S  + V EPPV +  P   Q  +    G  +E    +S  G  V+W 
Sbjct: 435  QC----VVGGEKCSTELFVKEPPVLITRPLEDQLVM---VGQRVEFECEVSEEGAQVKWL 487

Query: 1304 KDGERLASQG--RVQLEQAGARQVLRVQGARSGDAGEY-LCDAPQDSRIFLVSVEEPLLV 1360
            KDG  L  +   + + ++ G R  L +  A   DAG Y LC +   +   L+  E+ L  
Sbjct: 488  KDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKL-- 545

Query: 1361 KLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRG 1420
            ++   +  L V   D A F+CEVS  +    WL+NG  + P  +++++  G    LT+  
Sbjct: 546  EVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDD 605

Query: 1421 CQLGDAGTVTLRAGSTA--TSARLHVRETELLFLRR 1454
                D    +      A   SA+LH  E ++ F+ R
Sbjct: 606  VTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPR 641



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 86/349 (24%), Positives = 137/349 (39%), Gaps = 45/349 (12%)

Query: 825  VMLACEVDREDAPVRWYKDGQEVEESDF-VVLENEGPHRRLVLPATQPSDGGEFQCVAGD 883
            + L  E+   DA V+W K+GQE++ S    + E+ G  R L +     +D   +QCV G 
Sbjct: 381  IRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGG 440

Query: 884  ECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVV--ES 941
            E     + + +    I  P     V     +RV   CE+    A+V+W KDG E+   E+
Sbjct: 441  EKCSTELFVKEPPVLITRPLEDQLVMVG--QRVEFECEVSEEGAQVKWLKDGVELTREET 498

Query: 942  PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIA 1001
                 +K+     L++    LED+G Y        A   + V E  + +   +    L+ 
Sbjct: 499  FKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVY--QSIADLMV 556

Query: 1002 VTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGE--- 1058
               +  V  CE+S E+    W K+G E+     + +   G   +L +    P D  +   
Sbjct: 557  GAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSF 616

Query: 1059 ----FVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRV----------ELRCE 1104
                F C+      F  V +   P +          +H   PGR+          +LR +
Sbjct: 617  VPEGFACNLSAKLHFMEVKIDFVPRQ------EPPKIHLDCPGRIPDTIVVVAGNKLRLD 670

Query: 1105 VAPAGS---QVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGE 1150
            V  +G     V W K         A+  G + P R    P A PED G+
Sbjct: 671  VPISGDPAPTVIWQK---------AITQGNKAPAR--PAPDA-PEDTGD 707



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 61/240 (25%), Positives = 103/240 (42%), Gaps = 9/240 (3%)

Query: 733 RVVLTCELSRVDFPATWYKDGQKVEES-ELLVVKMDGRKHRLILPEAKVQDSGEFECRTE 791
           ++ LT EL+  D    W K+GQ+++ S    + +  G K  L + +  + D   ++C   
Sbjct: 380 KIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVG 439

Query: 792 GVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEV--EE 849
           G      + V++PPV I  P E   V  +  + V   CEV  E A V+W KDG E+  EE
Sbjct: 440 GEKCSTELFVKEPPVLITRPLEDQLV--MVGQRVEFECEVSEEGAQVKWLKDGVELTREE 497

Query: 850 SDFVVLENEGPHRRLVLPATQPSDGGEFQ-CVAGDECAYFTVTITDVSSWIVYPSGKVYV 908
           +     + +G    L++      D G +  C +G +       I       VY S    +
Sbjct: 498 TFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQA--LAELIVQEKKLEVYQSIADLM 555

Query: 909 AAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
              + ++ V  CE+        W K+G+E+V    + +     V +L +  V   D  +Y
Sbjct: 556 VGAK-DQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADY 614



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 61/239 (25%), Positives = 107/239 (44%), Gaps = 22/239 (9%)

Query: 647 WFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQD 704
           W  NG+E++ +           +Y  E  G +  L +      D  A   + C   G + 
Sbjct: 396 WLKNGQEIQMS---------GSKYIFESIGAKRTLTISQCSLADDAA---YQCVVGGEKC 443

Query: 705 SAALTIQESPVHILSP-QDRVSLTFTTSERVVLTCELSRVDFPATWYKDGQKV--EESEL 761
           S  L ++E PV I  P +D++ +     +RV   CE+S       W KDG ++  EE+  
Sbjct: 444 STELFVKEPPVLITRPLEDQLVMV---GQRVEFECEVSEEGAQVKWLKDGVELTREETFK 500

Query: 762 LVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAIT 821
              K DG++H LI+ EA ++D+G +   T G  A   + VQ+  + +      + V A  
Sbjct: 501 YRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGA-- 558

Query: 822 SECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCV 880
            +  +  CEV  E+    W K+G+E+     + + + G   +L +    P+D  ++  V
Sbjct: 559 KDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFV 617



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 155/681 (22%), Positives = 251/681 (36%), Gaps = 94/681 (13%)

Query: 614  PTARLVAGLEDVQVYDGEDAVFSLDLSTI-IQGTWFLNGEELKSNEPEGQVEPGALRYRI 672
            P   +   LED  V  G+   F  ++S    Q  W  +G EL   E          +YR 
Sbjct: 452  PPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREE--------TFKYRF 503

Query: 673  EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
            ++ G +H LI++    +D+G        G Q  A L +QE  + +   Q    L     +
Sbjct: 504  KKDGQRHHLIINEAMLEDAGHYA-LCTSGGQALAELIVQEKKLEVY--QSIADLMVGAKD 560

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            + V  CE+S  +    W K+G+++     + V   GR H+L + +    D  ++    EG
Sbjct: 561  QAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEG 620

Query: 793  VSA-------FFGVTV-----QDPP-VHIVDP-REHVFVHAITSECVMLACEVDREDAP- 837
             +        F  V +     Q+PP +H+  P R    +  +    + L   +  + AP 
Sbjct: 621  FACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPT 680

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQ-PSDGGEFQCVAGDECAYFTVTITDVS 896
            V W K          +   N+ P R    PA   P D G+      DE  +    + +  
Sbjct: 681  VIWQK---------AITQGNKAPAR----PAPDAPEDTGD-----SDEWVFDKKLLCET- 721

Query: 897  SWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLV 956
                   G+V V   + +R + T E      E  +T      V++P    Q   TV+ + 
Sbjct: 722  ------EGRVRVETTK-DRSIFTVEGAEKEDEGVYT----VTVKNPVGEDQVNLTVKVID 770

Query: 957  LP----AVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCE 1012
            +P    A ++ + GE  C +  E  ++     +P +  I  R +            L+ E
Sbjct: 771  VPDAPAAPKISNVGEDSCTVQWEPPAY--DGGQPILGYILERKKKKSYRWMRLNFDLIQE 828

Query: 1013 LSREDAPVRWYKDG----LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSA 1068
            LS E    R   +G    + V    A+ + R  P  +  +P   P +       A +D +
Sbjct: 829  LSHE---ARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHL---AVEDVS 882

Query: 1069 FFTVTVT-APPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDAL 1127
              TV++   PPER+            GA G      E  P G    W    L+       
Sbjct: 883  DTTVSLKWRPPERV------------GAGGLDGYSVEYCPEGCS-EWVA-ALQGLTEHTS 928

Query: 1128 QLGAEGPTRTLTLPHAQPED-AGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVA 1186
             L  + PT    L   +  + AG     T  E +T   IL  P +Q          +   
Sbjct: 929  ILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPRLQL--PRHLRQTIQKK 986

Query: 1187 PGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC 1245
             GEPV L         P V W+  G+P+  GE + +       +L I+AA   H+G Y  
Sbjct: 987  VGEPVNLLIPFQGKPRPQVTWTKEGQPL-AGEEVSIRNSPTDTILFIRAARRVHSGTYQV 1045

Query: 1246 QSGAAPGAPSLSFTVQVAEPP 1266
                       +  +QV + P
Sbjct: 1046 TVRIENMEDKATLVLQVVDKP 1066



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 59/232 (25%), Positives = 95/232 (40%), Gaps = 14/232 (6%)

Query: 274 EPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQ 333
           + E++W   G+ +     + ++        L +  C   D   Y C      G    + +
Sbjct: 391 DAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVV----GGEKCSTE 446

Query: 334 LHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLL--PCRKYEQIEE 391
           L VKEP +  TRPL+D           EC+V        W ++   L      KY   ++
Sbjct: 447 LFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKD 506

Query: 392 GTVRRLIIHRLKADDDGIY-LCEMRGRVRTVANVTVKGPILKRLPRKLDVLEG--ENAVL 448
           G    LII+    +D G Y LC   G+   +A + V+   L+      D++ G  + AV 
Sbjct: 507 GQRHHLIINEAMLEDAGHYALCTSGGQA--LAELIVQEKKLEVYQSIADLMVGAKDQAVF 564

Query: 449 LVETLEAGVEGRWSRDGEEL---PVICQSSSGHMHALVLPGVTREDAGEVTF 497
             E  +  V G W ++G+EL     I  S  G +H L +  VT  D  + +F
Sbjct: 565 KCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSF 616



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 6/140 (4%)

Query: 1750 RWELGGRPLR-PGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPL 1808
            +W   G+ ++  G++      G K  L +S+    D    +   G  +    L V+  P+
Sbjct: 395  KWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPV 454

Query: 1809 QMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGD--KYEMRSHGPTHSLV 1866
             + R P  ++ V+VG+R   E  VS  G  V WL++G EL   +  KY  +  G  H L+
Sbjct: 455  LITR-PLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLI 513

Query: 1867 IHDVRPEDQGTY--CCQAGQ 1884
            I++   ED G Y  C   GQ
Sbjct: 514  INEAMLEDAGHYALCTSGGQ 533



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 29/87 (33%), Positives = 41/87 (47%)

Query: 1807 PLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLV 1866
            P+      PR   V  G  AV E    R+G  V W R G+++   +KY + + G  H+L 
Sbjct: 8    PVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLT 67

Query: 1867 IHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            + +V P DQG+Y   AG       L V
Sbjct: 68   VREVGPADQGSYAVIAGSSKVKFDLKV 94



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 25/72 (34%), Positives = 40/72 (55%)

Query: 1635 PHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSD 1694
            P  +EV  G  A FE E  +A   V W++ G+ ++ S +  L   GTR  L +R  GP+D
Sbjct: 16   PRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPAD 75

Query: 1695 AGTYSCAVGTAR 1706
             G+Y+   G+++
Sbjct: 76   QGSYAVIAGSSK 87



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 34/112 (30%), Positives = 46/112 (41%), Gaps = 6/112 (5%)

Query: 1175 ALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQA 1234
            A    P  + VA G P V   E  RAG  V W   G  +       L  EG R  L ++ 
Sbjct: 11   AFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVRE 70

Query: 1235 AGPAHAGLYTCQSGAAPGAPSLSFTVQV--AEPPVRVVAPEAAQTRVRSTPG 1284
             GPA  G Y   +G++     + F ++V  AE    ++AP  A       PG
Sbjct: 71   VGPADQGSYAVIAGSS----KVKFDLKVIEAEKAEPMLAPAPAPAEATGAPG 118



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 29/82 (35%), Positives = 36/82 (43%)

Query: 23   VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVY 82
            V++G  A L C V G P P + W K G  L    R    +      L +    P D G+Y
Sbjct: 1192 VIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIY 1251

Query: 83   VCRARNAAGEAYAAAAVTVLEP 104
            VCRA N  GEA     + V  P
Sbjct: 1252 VCRATNLQGEARCECRLEVRVP 1273



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 36/125 (28%), Positives = 55/125 (44%), Gaps = 11/125 (8%)

Query: 14  FLRFPRPVRVVSGAEAELKCVVLGEPPPVVV-WEKGGQQLAASERLSFPADGAEHGLLLT 72
           F + PR V V +G+ A  +     E   V V W++GG  ++AS +     +G  H L + 
Sbjct: 12  FSKKPRSVEVAAGSPAVFEAET--ERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVR 69

Query: 73  AALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLT 132
              P D G Y       AG +     + V+E   ++P L PA    P+P    GAP    
Sbjct: 70  EVGPADQGSYAV----IAGSSKVKFDLKVIEAEKAEPMLAPA----PAPAEATGAPGEAP 121

Query: 133 GPRSQ 137
            P ++
Sbjct: 122 APAAE 126



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 36/114 (31%), Positives = 51/114 (44%), Gaps = 6/114 (5%)

Query: 227  HQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
            ++PP     D  EAP+   +PL        V  G  A   C V G P+P+I W   G  L
Sbjct: 1167 YEPPNYKALDFSEAPS-FTQPLVNRS----VIAGYTAMLCCAVRGSPKPKISWFKNGLDL 1221

Query: 287  LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPR 340
              D R  M+  + G   L++      D G+YVC A N  G+     +L V+ P+
Sbjct: 1222 GEDARFRMF-SKQGVLTLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVPQ 1274



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 32/103 (31%), Positives = 44/103 (42%), Gaps = 9/103 (8%)

Query: 127  APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
            AP F     ++ V+ G   +L C   G P+P + W K+G+ L E      F+ Q      
Sbjct: 1180 APSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQ------ 1233

Query: 187  GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQP 229
                 L L I      D G+YVC A N  G A+    L+V  P
Sbjct: 1234 ---GVLTLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVP 1273



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 2/70 (2%)

Query: 1451 FLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIH 1510
            F ++ + V    G     E ET R G    VRW RGG  +   ++  +A +G  H L + 
Sbjct: 12   FSKKPRSVEVAAGSPAVFEAETERAGVK--VRWQRGGSDISASNKYGLATEGTRHTLTVR 69

Query: 1511 GVILADQGTY 1520
             V  ADQG+Y
Sbjct: 70   EVGPADQGSY 79



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 53/224 (23%), Positives = 89/224 (39%), Gaps = 27/224 (12%)

Query: 189 GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
           GA   L I    L D   Y C      G  +    L V +PP             +  PL
Sbjct: 416 GAKRTLTISQCSLADDAAYQCVV----GGEKCSTELFVKEPP-----------VLITRPL 460

Query: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
           +       V  G+  +F C V  +   +++W  +G  L  +     YR +  G    ++ 
Sbjct: 461 EDQ----LVMVGQRVEFECEV-SEEGAQVKWLKDGVELTREET-FKYRFKKDGQRHHLII 514

Query: 309 CQA--KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
            +A  +D G Y  A   S GQ L+  +L V+E +L   + + D+       AV +C+V +
Sbjct: 515 NEAMLEDAGHY--ALCTSGGQALA--ELIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSD 570

Query: 367 SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY 410
             +   W +  + L+P  + +    G V +L I  +   D+  Y
Sbjct: 571 ENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADY 614



 Score = 40.0 bits (92), Expect = 0.022
 Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 4/98 (4%)

Query: 1726 RSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDA 1785
            RSV    G  A FE          RW+ GG  +    +  +  EG +H L + E+   D 
Sbjct: 17   RSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQ 76

Query: 1786 GEVRFQAGPAQ---SLALLEVE-ALPLQMCRHPPREKT 1819
            G     AG ++    L ++E E A P+      P E T
Sbjct: 77   GSYAVIAGSSKVKFDLKVIEAEKAEPMLAPAPAPAEAT 114



 Score = 39.7 bits (91), Expect = 0.028
 Identities = 25/79 (31%), Positives = 37/79 (46%), Gaps = 3/79 (3%)

Query: 435 PRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ---SSSGHMHALVLPGVTRED 491
           PR ++V  G  AV   ET  AGV+ RW R G ++    +   ++ G  H L +  V   D
Sbjct: 16  PRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPAD 75

Query: 492 AGEVTFSLGNSRTTTLLRV 510
            G      G+S+    L+V
Sbjct: 76  QGSYAVIAGSSKVKFDLKV 94



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 17/65 (26%), Positives = 29/65 (44%)

Query: 830 EVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFT 889
           E +R    VRW + G ++  S+   L  EG    L +    P+D G +  +AG     F 
Sbjct: 32  ETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFD 91

Query: 890 VTITD 894
           + + +
Sbjct: 92  LKVIE 96



 Score = 36.6 bits (83), Expect = 0.24
 Identities = 53/172 (30%), Positives = 66/172 (38%), Gaps = 26/172 (15%)

Query: 66   EHGLLLTAALPTDAGV-YVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSG 124
            EH  +L   LPT A + +  RA N AG     A VT  EP      LQ     LP     
Sbjct: 925  EHTSILVKDLPTGARLLFRVRAHNMAGPG---APVTTTEPVTVQEILQRPRLQLPR---- 977

Query: 125  EGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRA 184
                  L     + V  G  V L     G P P + W K+G  L         A +    
Sbjct: 978  -----HLRQTIQKKV--GEPVNLLIPFQGKPRPQVTWTKEGQPL---------AGEEVSI 1021

Query: 185  EDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPAD 236
             + P  ++ L I AAR   SG Y    R  +   +A  +LQV   P SPP D
Sbjct: 1022 RNSPTDTI-LFIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKP-SPPQD 1071



 Score = 36.2 bits (82), Expect = 0.31
 Identities = 53/232 (22%), Positives = 82/232 (35%), Gaps = 39/232 (16%)

Query: 28  EAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRAR 87
           +A  KC V  E    V W K G++L    R+     G  H L +    P D   Y     
Sbjct: 561 QAVFKCEVSDENVRGV-WLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADY----- 614

Query: 88  NAAGEAYA---AAAVTVLEPPASD-PELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGA 143
           +   E +A   +A +  +E      P  +P +  L  PG           P +  V+ G 
Sbjct: 615 SFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRI---------PDTIVVVAGN 665

Query: 144 EVVLTCRAGGLPEPTLYWEK-------------------DGMALDEVWDSSHFALQPGRA 184
           ++ L     G P PT+ W+K                    G + + V+D        GR 
Sbjct: 666 KLRLDVPISGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRV 725

Query: 185 EDGPGASLAL-RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPA 235
                   ++  +  A   D GVY    +N  G  Q    ++V   P++P A
Sbjct: 726 RVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAA 777



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 22/73 (30%), Positives = 30/73 (41%), Gaps = 1/73 (1%)

Query: 1823 GRRAVLEVTVSRSGGHVCWLREGAEL-CPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQ 1881
            G +  L V ++     V WL+ G E+   G KY   S G   +L I      D   Y C 
Sbjct: 378  GHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCV 437

Query: 1882 AGQDSTHTRLLVE 1894
             G +   T L V+
Sbjct: 438  VGGEKCSTELFVK 450



 Score = 35.8 bits (81), Expect = 0.41
 Identities = 33/105 (31%), Positives = 48/105 (45%), Gaps = 15/105 (14%)

Query: 6   GDQGSPPCFLRFP-----RPVR---VVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE- 56
           G++ S   F++ P     RP+    V+ G   E +C V  E    V W K G +L   E 
Sbjct: 440 GEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEV-SEEGAQVKWLKDGVELTREET 498

Query: 57  -RLSFPADGAEHGLLLTAALPTDAGVY-VCRARNAAGEAYAAAAV 99
            +  F  DG  H L++  A+  DAG Y +C    + G+A A   V
Sbjct: 499 FKYRFKKDGQRHHLIINEAMLEDAGHYALC---TSGGQALAELIV 540



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 5/102 (4%)

Query: 15   LRFPRPVRVVS----GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
            L+ PR +R       G    L     G+P P V W K GQ L A E +S      +  L 
Sbjct: 973  LQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPL-AGEEVSIRNSPTDTILF 1031

Query: 71   LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQ 112
            + AA    +G Y    R    E  A   + V++ P+   +L+
Sbjct: 1032 IRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLR 1073



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 28/122 (22%), Positives = 41/122 (33%), Gaps = 29/122 (23%)

Query: 13  CFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKG---GQQLAASERLSFPADGAEHG- 68
           C  R P  + VV+G +  L   + G+P P V+W+K    G +  A      P D  +   
Sbjct: 651 CPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDE 710

Query: 69  -------------------------LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLE 103
                                      +  A   D GVY    +N  GE      V V++
Sbjct: 711 WVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVID 770

Query: 104 PP 105
            P
Sbjct: 771 VP 772


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  117 bits (293), Expect = 1e-25
 Identities = 144/612 (23%), Positives = 224/612 (36%), Gaps = 132/612 (21%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
           PP  +  P  V V  G    L C   G P P + W K G+++   +      D   H +L
Sbjct: 46  PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDK-----DDPRSHRML 100

Query: 71  LTAA------------LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL 118
           L +                D G YVC ARN  GEA +  A   +     D          
Sbjct: 101 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD---------- 150

Query: 119 PSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCR-AGGLPEPTLYWEKDGMALDEVWDSSHF 177
                      F   P    V  G   +L C+   G PEPT+YW+KD + +D+       
Sbjct: 151 -----------FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDD--KEERI 197

Query: 178 ALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADP 237
           +++ G+          L I   R  D+G+Y C   N  G              +S PA+ 
Sbjct: 198 SIRGGK----------LMISNTRKSDAGMYTCVGTNMVGER------------DSDPAEL 235

Query: 238 D--EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMY 295
              E P  +  P+        V E +  +FRC V G P+P + W  +   L   R R   
Sbjct: 236 TVFERPTFLRRPINQV-----VLEEEAVEFRCQVQGDPQPTVRWKKDDADL--PRGRYDI 288

Query: 296 RDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREH 355
           +D    + L++    + D G Y+C A N  G+  ++  L V+ P     RP   +  +  
Sbjct: 289 KD---DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGR 345

Query: 356 GIAVLECKVPNSRIPTAWFRED--QRLL----PCRKYEQIEEGTVRRLIIHRLKADDDGI 409
            +    C+   +  P  +++++  Q LL    P +   +        L I  ++  D G 
Sbjct: 346 TV-TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 404

Query: 410 YLCEMRGRVRTVANVTVKGPILKRLPRKL-DVLEGENAVLLVE---TLEAGVEG----RW 461
           Y+C+          +TV G IL +   ++ DVL      ++++        V+G    + 
Sbjct: 405 YICQA---------LTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 455

Query: 462 SRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP---- 517
              G+ LPVI     G       P  T ++ G  T  + N R +      CV  S     
Sbjct: 456 KATGDPLPVISWLKEGFTFPGRDPRATIQEQG--TLQIKNLRISDTGTYTCVATSSSGET 513

Query: 518 ------------------------PGPPILAEMFKGHKNTVLLTWKPPEPA--PETPFIY 551
                                   PGPP   ++    KN+V L+W+P  P   P + +I 
Sbjct: 514 SWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYII 573

Query: 552 RLERQEVGSEDW 563
               Q V S  W
Sbjct: 574 EAFSQSV-SNSW 584



 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 100/353 (28%), Positives = 146/353 (41%), Gaps = 54/353 (15%)

Query: 122 GSGEGA--------PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWD 173
           G G+G+        P  +  P    V +G    L C+A G P PT+ W KDG  ++   D
Sbjct: 33  GQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKD 92

Query: 174 S--SHFALQPGRAEDGPGASLALRILAAR--LPDSGVYVCHARNAHGHA-QAGALLQVHQ 228
              SH  L P       G+   LRI+  R   PD G YVC ARN  G A    A L+V  
Sbjct: 93  DPRSHRMLLPS------GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL 146

Query: 229 PPESPPADPDEAPAPVVEP--LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL 286
             +    +P +      EP  L+C P                  G PEP I W  +   +
Sbjct: 147 LRDDFRQNPTDVVVAAGEPAILECQPP----------------RGHPEPTIYWKKDKVRI 190

Query: 287 LPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLS-AVQLHVKEPRLRFTR 345
                R+  R    G  L +   +  D G+Y C   N  G+  S   +L V E      R
Sbjct: 191 DDKEERISIR----GGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRR 246

Query: 346 PLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKAD 405
           P+  V   E  +    C+V     PT  +++D   LP  +Y+  ++ T+R   I +  + 
Sbjct: 247 PINQVVLEEEAVE-FRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLR---IKKTMST 302

Query: 406 DDGIYLC--EMR-GRVRTVANVTVKGP---ILKRLPRKLDVLEGENAVLLVET 452
           D+G Y+C  E R G++   A +TV+ P   +++  PR   V +G       ET
Sbjct: 303 DEGTYMCIAENRVGKMEASATLTVRAPPQFVVR--PRDQIVAQGRTVTFPCET 353



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 69/254 (27%), Positives = 98/254 (38%), Gaps = 53/254 (20%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG- 68
           +PP F+  PR   V  G      C   G P P V W+K G     S+ L FP    +   
Sbjct: 328 APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEG-----SQNLLFPNQPQQPNS 382

Query: 69  ---------LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
                    L +T    +DAG Y+C+A   AG   A A + V +     P          
Sbjct: 383 RCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP---------- 432

Query: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                   P+ L GP +Q +      +L C+A G P P + W K+G              
Sbjct: 433 -------PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF----------- 474

Query: 180 QPGRAEDGPGASL----ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE--SP 233
            PGR    P A++     L+I   R+ D+G Y C A ++ G     A+L V +     S 
Sbjct: 475 -PGR---DPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISK 530

Query: 234 PADPDEAPAPVVEP 247
             D  + P P  +P
Sbjct: 531 NYDLSDLPGPPSKP 544



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 132/501 (26%), Positives = 204/501 (40%), Gaps = 84/501 (16%)

Query: 1258 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLAS-----Q 1312
            F  ++ E P  V+  +   T +     G          P   + WYKDGER+ +     +
Sbjct: 45   FPPRIVEHPSDVIVSKGEPTTLNCKAEGR---------PTPTIEWYKDGERVETDKDDPR 95

Query: 1313 GRVQLEQAGARQVLR-VQGARS-GDAGEYLCDAPQDSRIFL---VSVEEPLLVKLVSE-- 1365
                L  +G+   LR V G RS  D G Y+C A    R +L   VS    L V L+ +  
Sbjct: 96   SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVA----RNYLGEAVSRNASLEVALLRDDF 151

Query: 1366 ---LTPLTVHEGDDATFRCEV--SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRG 1420
                T + V  G+ A   C+     P+  + W ++   +    +    + G    L +  
Sbjct: 152  RQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK---LMISN 208

Query: 1421 CQLGDAGTVT-----LRAGSTATSARLHVRETELLFLRR--LQDVRAEEGQDVCLEVETG 1473
             +  DAG  T     +     +  A L V E    FLRR   Q V  EE  +   +V+  
Sbjct: 209  TRKSDAGMYTCVGTNMVGERDSDPAELTVFERP-TFLRRPINQVVLEEEAVEFRCQVQG- 266

Query: 1474 RVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RT 1529
                   VRW +    LP   R  +  D   + L I   +  D+GTY C + +       
Sbjct: 267  --DPQPTVRWKKDDADLPR-GRYDIKDD---YTLRIKKTMSTDEGTYMCIAENRVGKMEA 320

Query: 1530 LARLSVRPRQLRVLRPLEDVTISEGGSATFQLELS---QEGVTGEWARGGVQ-------- 1578
             A L+VR     V+RP  D  +++G + TF  E     Q  V   W + G Q        
Sbjct: 321  SATLTVRAPPQFVVRP-RDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLLFPNQP 377

Query: 1579 LYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSFT-ADSLRCAARLIVREV-----PV 1629
              P  +C +   G    L +  +  +D+G   C + T A S+   A+L V +V     P 
Sbjct: 378  QQPNSRCSVSPTGD---LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 434

Query: 1630 TIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALT-PSPRLRLQALGTRRLLQL 1687
             I++GP +  +    TA  +C+ +   L  ++W K+G       PR  +Q  GT   LQ+
Sbjct: 435  IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT---LQI 491

Query: 1688 RRCGPSDAGTYSCAVGTARAG 1708
            +    SD GTY+C V T+ +G
Sbjct: 492  KNLRISDTGTYTC-VATSSSG 511



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 129/532 (24%), Positives = 203/532 (38%), Gaps = 120/532 (22%)

Query: 802  QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGP 860
            +D P  IV+    V V     E   L C+ +    P + WYKDG+ VE       +++  
Sbjct: 43   EDFPPRIVEHPSDVIVSK--GEPTTLNCKAEGRPTPTIEWYKDGERVETD-----KDDPR 95

Query: 861  HRRLVLPA------------TQPSDGGEFQCVAGDECAYFTVTITDVSSWIV------YP 902
              R++LP+                D G + CVA +   Y    ++  +S  V      + 
Sbjct: 96   SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARN---YLGEAVSRNASLEVALLRDDFR 152

Query: 903  SGKVYVAAVRLERVVLTCELCR--PWAEVRWTKDGEEVVESPALLLQKEDTVR--RLVLP 958
                 V     E  +L C+  R  P   + W KD   + +      ++  ++R  +L++ 
Sbjct: 153  QNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDK-----EERISIRGGKLMIS 207

Query: 959  AVQLEDSGEYLC-------EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMC 1011
              +  D+G Y C       E D + A   +TV E P  +  P ++V L     E V   C
Sbjct: 208  NTRKSDAGMYTCVGTNMVGERDSDPAE--LTVFERPTFLRRPINQVVLEE---EAVEFRC 262

Query: 1012 ELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDD 1066
            ++  +  P VRW KD  ++      + +    R +  +      D G ++C A    G  
Sbjct: 263  QVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMST----DEGTYMCIAENRVGKM 318

Query: 1067 SAFFTVTVTAPPERIVHPAARSLDLHFGAPGR-VELRCEVA----PAGSQVRWYKDGLEV 1121
             A  T+TV APP+ +V P  + +     A GR V   CE      PA   V W K+G + 
Sbjct: 319  EASATLTVRAPPQFVVRPRDQIV-----AQGRTVTFPCETKGNPQPA---VFWQKEGSQN 370

Query: 1122 -----EASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITF-------------- 1162
                 +        +  PT  LT+ + Q  DAG Y+C+    A +               
Sbjct: 371  LLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTD 430

Query: 1163 ---NVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEG 1218
                +IL  P  Q LA++ T    C A G+P+           PV+ W          EG
Sbjct: 431  RPPPIILQGPANQTLAVDGTALLKCKATGDPL-----------PVISWLK--------EG 471

Query: 1219 LELHAEGPRR------VLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
                   PR        L I+    +  G YTC + ++ G  S S  + V E
Sbjct: 472  FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 523



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 110/472 (23%), Positives = 179/472 (37%), Gaps = 79/472 (16%)

Query: 732  ERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKV---------- 780
            E   L C+      P   WYKDG++VE       K D R HR++LP   +          
Sbjct: 62   EPTTLNCKAEGRPTPTIEWYKDGERVETD-----KDDPRSHRMLLPSGSLFFLRIVHGRR 116

Query: 781  --QDSGEFECRTE---GVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDR-- 833
               D G + C      G +     +++   +     +    V     E  +L C+  R  
Sbjct: 117  SKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGH 176

Query: 834  EDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-----ECAYF 888
             +  + W KD   +++ +  +    G   +L++  T+ SD G + CV  +     +    
Sbjct: 177  PEPTIYWKKDKVRIDDKEERISIRGG---KLMISNTRKSDAGMYTCVGTNMVGERDSDPA 233

Query: 889  TVTITDVSSWIVYPSGKVYVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQ 947
             +T+ +  +++  P  +V    +  E V   C++   P   VRW KD  ++      +  
Sbjct: 234  ELTVFERPTFLRRPINQV---VLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDI-- 288

Query: 948  KEDTVRRLVLPAVQLEDSGEYLC----EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVT 1003
            K+D   R  +      D G Y+C     +    AS T+TV  PP  ++ PRD++     T
Sbjct: 289  KDDYTLR--IKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRT 346

Query: 1004 LECVVLMCELSREDAP-VRWYKDGLEVEESEALVL----ERDGPRCR------LVLPAAQ 1052
               V   CE      P V W K+G     S+ L+     ++   RC       L +   Q
Sbjct: 347  ---VTFPCETKGNPQPAVFWQKEG-----SQNLLFPNQPQQPNSRCSVSPTGDLTITNIQ 398

Query: 1053 PEDGGEFVCD----AGDDSAFFTVTVT------APPERIVHPAARSLDLHFGAPGRVELR 1102
              D G ++C     AG   A   + VT       PP  +  PA ++L       G   L+
Sbjct: 399  RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL----AVDGTALLK 454

Query: 1103 CEVAPAGSQV-RWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVC 1153
            C+       V  W K+G      D      E    TL + + +  D G Y C
Sbjct: 455  CKATGDPLPVISWLKEGFTFPGRDPRATIQE--QGTLQIKNLRISDTGTYTC 504



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 98/379 (25%), Positives = 152/379 (40%), Gaps = 54/379 (14%)

Query: 1541 RVLRPLEDVTISEGGSATFQLELSQEG---VTGEWARGGVQLYPGPKCHIHSDGHRHRLV 1597
            R++    DV +S+G   T  L    EG    T EW + G ++          D   HR++
Sbjct: 48   RIVEHPSDVIVSKGEPTT--LNCKAEGRPTPTIEWYKDGERVETDK-----DDPRSHRML 100

Query: 1598 LNGLGL------------ADSG---CVS--FTADSLRCAARLIVREVPVTIVRGPHDLEV 1640
            L    L             D G   CV+  +  +++   A L V  +     + P D+ V
Sbjct: 101  LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 160

Query: 1641 TEGDTATFECELSQALADVT--WEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
              G+ A  EC+  +   + T  W+KD   +      R+   G + ++   R   SDAG Y
Sbjct: 161  AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE-RISIRGGKLMISNTR--KSDAGMY 217

Query: 1699 SCA----VGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVS-EVETTGRWEL 1753
            +C     VG   + P  LTV ER   +   +  V   E +   F C V  + + T RW+ 
Sbjct: 218  TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE-EAVEFRCQVQGDPQPTVRWKK 276

Query: 1754 GGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVEALPLQ 1809
                L P  R  I+ +   + L + +  + D G        + G  ++ A L V A P  
Sbjct: 277  DDADL-PRGRYDIKDD---YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 332

Query: 1810 MCRHPPREKTVLVGRRAVLEV-TVSRSGGHVCWLREGAE--LCPGDKYEMRSH---GPTH 1863
            + R  PR++ V  GR       T       V W +EG++  L P    +  S     PT 
Sbjct: 333  VVR--PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 390

Query: 1864 SLVIHDVRPEDQGTYCCQA 1882
             L I +++  D G Y CQA
Sbjct: 391  DLTITNIQRSDAGYYICQA 409



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 117/522 (22%), Positives = 181/522 (34%), Gaps = 103/522 (19%)

Query: 986  PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRC 1044
            PP  + +P D   +I    E   L C+      P + WYKDG  VE       ++D PR 
Sbjct: 46   PPRIVEHPSD---VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVET------DKDDPRS 96

Query: 1045 -RLVLPAAQ------------PEDGGEFVC------------DAGDDSAFFTVTVTAPPE 1079
             R++LP+                D G +VC            +A  + A         P 
Sbjct: 97   HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 156

Query: 1080 RIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLT 1139
             +V  A        G P  +E +         + W KD + ++  +  ++   G    L 
Sbjct: 157  DVVVAA--------GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE-RISIRGGK--LM 205

Query: 1140 LPHAQPEDAGEYVCETRHEAITFNVI--LAEPPVQFLALETT-----PSPLCVAPGEPVV 1192
            + + +  DAG Y C      +  N++      P +    E       P    V   E V 
Sbjct: 206  ISNTRKSDAGMYTC------VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVE 259

Query: 1193 LSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAP 1251
              C++     P V W  +   +  G     +       L I+       G Y C +    
Sbjct: 260  FRCQVQGDPQPTVRWKKDDADLPRGR----YDIKDDYTLRIKKTMSTDEGTYMCIAENRV 315

Query: 1252 GAPSLSFTVQVAEPPVRVVAPE---AAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGER 1308
            G    S T+ V  PP  VV P     AQ R  + P            P   V W K+G +
Sbjct: 316  GKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP------CETKGNPQPAVFWQKEGSQ 369

Query: 1309 --------LASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLV 1360
                         R  +   G   +  +Q     DAG Y+C A   +   L   +  +  
Sbjct: 370  NLLFPNQPQQPNSRCSVSPTGDLTITNIQ---RSDAGYYICQALTVAGSILAKAQLEVTD 426

Query: 1361 KLVSELTPL--------TVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPG--PQVEMAQ 1409
             L     P+        T+     A  +C+ +  P   ++WL+ G    PG  P+  + +
Sbjct: 427  VLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG-FTFPGRDPRATIQE 485

Query: 1410 NGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRET 1447
             G+ +I  LR   + D GT T  A    G T+ SA L V E+
Sbjct: 486  QGTLQIKNLR---ISDTGTYTCVATSSSGETSWSAVLDVTES 524



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 80/294 (27%), Positives = 122/294 (41%), Gaps = 37/294 (12%)

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQA 1678
            A L V E P T +R P +  V E +   F C++       V W+KD   L   PR R   
Sbjct: 233  AELTVFERP-TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL---PRGRYD- 287

Query: 1679 LGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVR----LTVRERTVAVLSELRSVSAREGD 1734
            +     L++++   +D GTY C +   R G +     LTVR     V+     + A +G 
Sbjct: 288  IKDDYTLRIKKTMSTDEGTYMC-IAENRVGKMEASATLTVRAPPQFVVRPRDQIVA-QGR 345

Query: 1735 GATFEC-TVSEVETTGRWELGG--------RPLRPGARVRIRQEGKKHILVLSELRAEDA 1785
              TF C T    +    W+  G        +P +P +R  +   G    L ++ ++  DA
Sbjct: 346  TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD---LTITNIQRSDA 402

Query: 1786 GEVRFQA----GPAQSLALLEVEAL----PLQMCRHPPREKTVLVGRRAVLEVTVSRSGG 1837
            G    QA    G   + A LEV  +    P  +    P  +T+ V   A+L+   +    
Sbjct: 403  GYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 462

Query: 1838 HVC-WLREGAELCPGD-KYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHT 1889
             V  WL+EG      D +  ++  G   +L I ++R  D GTY C A   S  T
Sbjct: 463  PVISWLKEGFTFPGRDPRATIQEQG---TLQIKNLRISDTGTYTCVATSSSGET 513



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 43/201 (21%), Positives = 75/201 (37%), Gaps = 33/201 (16%)

Query: 702 VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDG------- 753
           ++ SA LT++  P  ++ P+D++         V   CE      PA  W K+G       
Sbjct: 318 MEASATLTVRAPPQFVVRPRDQI---VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 374

Query: 754 -QKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFF----------GVTVQ 802
            Q  + +    V   G    L +   +  D+G + C+   V+              +T +
Sbjct: 375 NQPQQPNSRCSVSPTG---DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 431

Query: 803 DPPVHIVDPREHVFVHAITSECVMLACEVDREDAPV-RWYKDGQEVEESD-FVVLENEGP 860
            PP+ +  P              +L C+   +  PV  W K+G      D    ++ +G 
Sbjct: 432 PPPIILQGPANQTLA---VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQG- 487

Query: 861 HRRLVLPATQPSDGGEFQCVA 881
              L +   + SD G + CVA
Sbjct: 488 --TLQIKNLRISDTGTYTCVA 506


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  117 bits (293), Expect = 1e-25
 Identities = 144/612 (23%), Positives = 224/612 (36%), Gaps = 132/612 (21%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
           PP  +  P  V V  G    L C   G P P + W K G+++   +      D   H +L
Sbjct: 30  PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDK-----DDPRSHRML 84

Query: 71  LTAA------------LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPL 118
           L +                D G YVC ARN  GEA +  A   +     D          
Sbjct: 85  LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD---------- 134

Query: 119 PSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCR-AGGLPEPTLYWEKDGMALDEVWDSSHF 177
                      F   P    V  G   +L C+   G PEPT+YW+KD + +D+       
Sbjct: 135 -----------FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDD--KEERI 181

Query: 178 ALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADP 237
           +++ G+          L I   R  D+G+Y C   N  G              +S PA+ 
Sbjct: 182 SIRGGK----------LMISNTRKSDAGMYTCVGTNMVGER------------DSDPAEL 219

Query: 238 D--EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMY 295
              E P  +  P+        V E +  +FRC V G P+P + W  +   L   R R   
Sbjct: 220 TVFERPTFLRRPINQV-----VLEEEAVEFRCQVQGDPQPTVRWKKDDADL--PRGRYDI 272

Query: 296 RDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREH 355
           +D    + L++    + D G Y+C A N  G+  ++  L V+ P     RP   +  +  
Sbjct: 273 KD---DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGR 329

Query: 356 GIAVLECKVPNSRIPTAWFRED--QRLL----PCRKYEQIEEGTVRRLIIHRLKADDDGI 409
            +    C+   +  P  +++++  Q LL    P +   +        L I  ++  D G 
Sbjct: 330 TV-TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 388

Query: 410 YLCEMRGRVRTVANVTVKGPILKRLPRKL-DVLEGENAVLLVE---TLEAGVEG----RW 461
           Y+C+          +TV G IL +   ++ DVL      ++++        V+G    + 
Sbjct: 389 YICQA---------LTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 439

Query: 462 SRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSP---- 517
              G+ LPVI     G       P  T ++ G  T  + N R +      CV  S     
Sbjct: 440 KATGDPLPVISWLKEGFTFPGRDPRATIQEQG--TLQIKNLRISDTGTYTCVATSSSGET 497

Query: 518 ------------------------PGPPILAEMFKGHKNTVLLTWKPPEPA--PETPFIY 551
                                   PGPP   ++    KN+V L+W+P  P   P + +I 
Sbjct: 498 SWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYII 557

Query: 552 RLERQEVGSEDW 563
               Q V S  W
Sbjct: 558 EAFSQSV-SNSW 568



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 69/254 (27%), Positives = 98/254 (38%), Gaps = 53/254 (20%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG- 68
           +PP F+  PR   V  G      C   G P P V W+K G     S+ L FP    +   
Sbjct: 312 APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEG-----SQNLLFPNQPQQPNS 366

Query: 69  ---------LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
                    L +T    +DAG Y+C+A   AG   A A + V +     P          
Sbjct: 367 RCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP---------- 416

Query: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
                   P+ L GP +Q +      +L C+A G P P + W K+G              
Sbjct: 417 -------PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF----------- 458

Query: 180 QPGRAEDGPGASL----ALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPE--SP 233
            PGR    P A++     L+I   R+ D+G Y C A ++ G     A+L V +     S 
Sbjct: 459 -PGR---DPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISK 514

Query: 234 PADPDEAPAPVVEP 247
             D  + P P  +P
Sbjct: 515 NYDLSDLPGPPSKP 528



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 132/501 (26%), Positives = 204/501 (40%), Gaps = 84/501 (16%)

Query: 1258 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLAS-----Q 1312
            F  ++ E P  V+  +   T +     G          P   + WYKDGER+ +     +
Sbjct: 29   FPPRIVEHPSDVIVSKGEPTTLNCKAEGR---------PTPTIEWYKDGERVETDKDDPR 79

Query: 1313 GRVQLEQAGARQVLR-VQGARS-GDAGEYLCDAPQDSRIFL---VSVEEPLLVKLVSE-- 1365
                L  +G+   LR V G RS  D G Y+C A    R +L   VS    L V L+ +  
Sbjct: 80   SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVA----RNYLGEAVSRNASLEVALLRDDF 135

Query: 1366 ---LTPLTVHEGDDATFRCEV--SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRG 1420
                T + V  G+ A   C+     P+  + W ++   +    +    + G    L +  
Sbjct: 136  RQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK---LMISN 192

Query: 1421 CQLGDAGTVT-----LRAGSTATSARLHVRETELLFLRR--LQDVRAEEGQDVCLEVETG 1473
             +  DAG  T     +     +  A L V E    FLRR   Q V  EE  +   +V+  
Sbjct: 193  TRKSDAGMYTCVGTNMVGERDSDPAELTVFERP-TFLRRPINQVVLEEEAVEFRCQVQG- 250

Query: 1474 RVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD----RT 1529
                   VRW +    LP   R  +  D   + L I   +  D+GTY C + +       
Sbjct: 251  --DPQPTVRWKKDDADLPR-GRYDIKDD---YTLRIKKTMSTDEGTYMCIAENRVGKMEA 304

Query: 1530 LARLSVRPRQLRVLRPLEDVTISEGGSATFQLELS---QEGVTGEWARGGVQ-------- 1578
             A L+VR     V+RP  D  +++G + TF  E     Q  V   W + G Q        
Sbjct: 305  SATLTVRAPPQFVVRP-RDQIVAQGRTVTFPCETKGNPQPAVF--WQKEGSQNLLFPNQP 361

Query: 1579 LYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSFT-ADSLRCAARLIVREV-----PV 1629
              P  +C +   G    L +  +  +D+G   C + T A S+   A+L V +V     P 
Sbjct: 362  QQPNSRCSVSPTGD---LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 418

Query: 1630 TIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALT-PSPRLRLQALGTRRLLQL 1687
             I++GP +  +    TA  +C+ +   L  ++W K+G       PR  +Q  GT   LQ+
Sbjct: 419  IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT---LQI 475

Query: 1688 RRCGPSDAGTYSCAVGTARAG 1708
            +    SD GTY+C V T+ +G
Sbjct: 476  KNLRISDTGTYTC-VATSSSG 495



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 129/532 (24%), Positives = 203/532 (38%), Gaps = 120/532 (22%)

Query: 802  QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGP 860
            +D P  IV+    V V     E   L C+ +    P + WYKDG+ VE       +++  
Sbjct: 27   EDFPPRIVEHPSDVIVSK--GEPTTLNCKAEGRPTPTIEWYKDGERVETD-----KDDPR 79

Query: 861  HRRLVLPA------------TQPSDGGEFQCVAGDECAYFTVTITDVSSWIV------YP 902
              R++LP+                D G + CVA +   Y    ++  +S  V      + 
Sbjct: 80   SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARN---YLGEAVSRNASLEVALLRDDFR 136

Query: 903  SGKVYVAAVRLERVVLTCELCR--PWAEVRWTKDGEEVVESPALLLQKEDTVR--RLVLP 958
                 V     E  +L C+  R  P   + W KD   + +      ++  ++R  +L++ 
Sbjct: 137  QNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDK-----EERISIRGGKLMIS 191

Query: 959  AVQLEDSGEYLC-------EIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMC 1011
              +  D+G Y C       E D + A   +TV E P  +  P ++V L     E V   C
Sbjct: 192  NTRKSDAGMYTCVGTNMVGERDSDPAE--LTVFERPTFLRRPINQVVLEE---EAVEFRC 246

Query: 1012 ELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDD 1066
            ++  +  P VRW KD  ++      + +    R +  +      D G ++C A    G  
Sbjct: 247  QVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMST----DEGTYMCIAENRVGKM 302

Query: 1067 SAFFTVTVTAPPERIVHPAARSLDLHFGAPGR-VELRCEVA----PAGSQVRWYKDGLEV 1121
             A  T+TV APP+ +V P  + +     A GR V   CE      PA   V W K+G + 
Sbjct: 303  EASATLTVRAPPQFVVRPRDQIV-----AQGRTVTFPCETKGNPQPA---VFWQKEGSQN 354

Query: 1122 -----EASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITF-------------- 1162
                 +        +  PT  LT+ + Q  DAG Y+C+    A +               
Sbjct: 355  LLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTD 414

Query: 1163 ---NVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEG 1218
                +IL  P  Q LA++ T    C A G+P+           PV+ W          EG
Sbjct: 415  RPPPIILQGPANQTLAVDGTALLKCKATGDPL-----------PVISWLK--------EG 455

Query: 1219 LELHAEGPRR------VLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
                   PR        L I+    +  G YTC + ++ G  S S  + V E
Sbjct: 456  FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 507



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 116/501 (23%), Positives = 191/501 (38%), Gaps = 83/501 (16%)

Query: 704  DSAALTIQESPVHILS-PQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESEL 761
            D + L  ++ P  I+  P D +    +  E   L C+      P   WYKDG++VE    
Sbjct: 20   DGSRLRQEDFPPRIVEHPSDVI---VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD-- 74

Query: 762  LVVKMDGRKHRLILPEAKV------------QDSGEFECRTE---GVSAFFGVTVQDPPV 806
               K D R HR++LP   +             D G + C      G +     +++   +
Sbjct: 75   ---KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL 131

Query: 807  HIVDPREHVFVHAITSECVMLACEVDR--EDAPVRWYKDGQEVEESDFVVLENEGPHRRL 864
                 +    V     E  +L C+  R   +  + W KD   +++ +  +    G   +L
Sbjct: 132  RDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGG---KL 188

Query: 865  VLPATQPSDGGEFQCVAGD-----ECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLT 919
            ++  T+ SD G + CV  +     +     +T+ +  +++  P  +V    +  E V   
Sbjct: 189  MISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQV---VLEEEAVEFR 245

Query: 920  CEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC----EIDD 974
            C++   P   VRW KD  ++      +  K+D   R  +      D G Y+C     +  
Sbjct: 246  CQVQGDPQPTVRWKKDDADLPRGRYDI--KDDYTLR--IKKTMSTDEGTYMCIAENRVGK 301

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESE 1033
              AS T+TV  PP  ++ PRD++     T   V   CE      P V W K+G     S+
Sbjct: 302  MEASATLTVRAPPQFVVRPRDQIVAQGRT---VTFPCETKGNPQPAVFWQKEG-----SQ 353

Query: 1034 ALVL----ERDGPRCR------LVLPAAQPEDGGEFVCD----AGDDSAFFTVTVT---- 1075
             L+     ++   RC       L +   Q  D G ++C     AG   A   + VT    
Sbjct: 354  NLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413

Query: 1076 --APPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQV-RWYKDGLEVEASDALQLGAE 1132
               PP  +  PA ++L       G   L+C+       V  W K+G      D      E
Sbjct: 414  DRPPPIILQGPANQTL----AVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQE 469

Query: 1133 GPTRTLTLPHAQPEDAGEYVC 1153
                TL + + +  D G Y C
Sbjct: 470  --QGTLQIKNLRISDTGTYTC 488



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 98/379 (25%), Positives = 152/379 (40%), Gaps = 54/379 (14%)

Query: 1541 RVLRPLEDVTISEGGSATFQLELSQEG---VTGEWARGGVQLYPGPKCHIHSDGHRHRLV 1597
            R++    DV +S+G   T  L    EG    T EW + G ++          D   HR++
Sbjct: 32   RIVEHPSDVIVSKGEPTT--LNCKAEGRPTPTIEWYKDGERVETDK-----DDPRSHRML 84

Query: 1598 LNGLGL------------ADSG---CVS--FTADSLRCAARLIVREVPVTIVRGPHDLEV 1640
            L    L             D G   CV+  +  +++   A L V  +     + P D+ V
Sbjct: 85   LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 144

Query: 1641 TEGDTATFECELSQALADVT--WEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
              G+ A  EC+  +   + T  W+KD   +      R+   G + ++   R   SDAG Y
Sbjct: 145  AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE-RISIRGGKLMISNTR--KSDAGMY 201

Query: 1699 SCA----VGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVS-EVETTGRWEL 1753
            +C     VG   + P  LTV ER   +   +  V   E +   F C V  + + T RW+ 
Sbjct: 202  TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE-EAVEFRCQVQGDPQPTVRWKK 260

Query: 1754 GGRPLRPGARVRIRQEGKKHILVLSELRAEDAGE----VRFQAGPAQSLALLEVEALPLQ 1809
                L P  R  I+ +   + L + +  + D G        + G  ++ A L V A P  
Sbjct: 261  DDADL-PRGRYDIKDD---YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 316

Query: 1810 MCRHPPREKTVLVGRRAVLEV-TVSRSGGHVCWLREGAE--LCPGDKYEMRSH---GPTH 1863
            + R  PR++ V  GR       T       V W +EG++  L P    +  S     PT 
Sbjct: 317  VVR--PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 374

Query: 1864 SLVIHDVRPEDQGTYCCQA 1882
             L I +++  D G Y CQA
Sbjct: 375  DLTITNIQRSDAGYYICQA 393



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 117/522 (22%), Positives = 181/522 (34%), Gaps = 103/522 (19%)

Query: 986  PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRC 1044
            PP  + +P D   +I    E   L C+      P + WYKDG  VE       ++D PR 
Sbjct: 30   PPRIVEHPSD---VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVET------DKDDPRS 80

Query: 1045 -RLVLPAAQ------------PEDGGEFVC------------DAGDDSAFFTVTVTAPPE 1079
             R++LP+                D G +VC            +A  + A         P 
Sbjct: 81   HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140

Query: 1080 RIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLT 1139
             +V  A        G P  +E +         + W KD + ++  +  ++   G    L 
Sbjct: 141  DVVVAA--------GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE-RISIRGGK--LM 189

Query: 1140 LPHAQPEDAGEYVCETRHEAITFNVI--LAEPPVQFLALETT-----PSPLCVAPGEPVV 1192
            + + +  DAG Y C      +  N++      P +    E       P    V   E V 
Sbjct: 190  ISNTRKSDAGMYTC------VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVE 243

Query: 1193 LSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAP 1251
              C++     P V W  +   +  G     +       L I+       G Y C +    
Sbjct: 244  FRCQVQGDPQPTVRWKKDDADLPRGR----YDIKDDYTLRIKKTMSTDEGTYMCIAENRV 299

Query: 1252 GAPSLSFTVQVAEPPVRVVAPE---AAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGER 1308
            G    S T+ V  PP  VV P     AQ R  + P            P   V W K+G +
Sbjct: 300  GKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP------CETKGNPQPAVFWQKEGSQ 353

Query: 1309 --------LASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLV 1360
                         R  +   G   +  +Q     DAG Y+C A   +   L   +  +  
Sbjct: 354  NLLFPNQPQQPNSRCSVSPTGDLTITNIQ---RSDAGYYICQALTVAGSILAKAQLEVTD 410

Query: 1361 KLVSELTPL--------TVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPG--PQVEMAQ 1409
             L     P+        T+     A  +C+ +  P   ++WL+ G    PG  P+  + +
Sbjct: 411  VLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG-FTFPGRDPRATIQE 469

Query: 1410 NGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRET 1447
             G+ +I  LR   + D GT T  A    G T+ SA L V E+
Sbjct: 470  QGTLQIKNLR---ISDTGTYTCVATSSSGETSWSAVLDVTES 508



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 80/294 (27%), Positives = 122/294 (41%), Gaps = 37/294 (12%)

Query: 1620 ARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQA 1678
            A L V E P T +R P +  V E +   F C++       V W+KD   L   PR R   
Sbjct: 217  AELTVFERP-TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL---PRGRYD- 271

Query: 1679 LGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVR----LTVRERTVAVLSELRSVSAREGD 1734
            +     L++++   +D GTY C +   R G +     LTVR     V+     + A +G 
Sbjct: 272  IKDDYTLRIKKTMSTDEGTYMC-IAENRVGKMEASATLTVRAPPQFVVRPRDQIVA-QGR 329

Query: 1735 GATFEC-TVSEVETTGRWELGG--------RPLRPGARVRIRQEGKKHILVLSELRAEDA 1785
              TF C T    +    W+  G        +P +P +R  +   G    L ++ ++  DA
Sbjct: 330  TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD---LTITNIQRSDA 386

Query: 1786 GEVRFQA----GPAQSLALLEVEAL----PLQMCRHPPREKTVLVGRRAVLEVTVSRSGG 1837
            G    QA    G   + A LEV  +    P  +    P  +T+ V   A+L+   +    
Sbjct: 387  GYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 446

Query: 1838 HVC-WLREGAELCPGD-KYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHT 1889
             V  WL+EG      D +  ++  G   +L I ++R  D GTY C A   S  T
Sbjct: 447  PVISWLKEGFTFPGRDPRATIQEQG---TLQIKNLRISDTGTYTCVATSSSGET 497



 Score = 32.0 bits (71), Expect = 5.9
 Identities = 43/201 (21%), Positives = 75/201 (37%), Gaps = 33/201 (16%)

Query: 702 VQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDG------- 753
           ++ SA LT++  P  ++ P+D++         V   CE      PA  W K+G       
Sbjct: 302 MEASATLTVRAPPQFVVRPRDQI---VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 358

Query: 754 -QKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFF----------GVTVQ 802
            Q  + +    V   G    L +   +  D+G + C+   V+              +T +
Sbjct: 359 NQPQQPNSRCSVSPTG---DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDR 415

Query: 803 DPPVHIVDPREHVFVHAITSECVMLACEVDREDAPV-RWYKDGQEVEESD-FVVLENEGP 860
            PP+ +  P              +L C+   +  PV  W K+G      D    ++ +G 
Sbjct: 416 PPPIILQGPANQTLA---VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQG- 471

Query: 861 HRRLVLPATQPSDGGEFQCVA 881
              L +   + SD G + CVA
Sbjct: 472 --TLQIKNLRISDTGTYTCVA 490


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score =  117 bits (293), Expect = 1e-25
 Identities = 126/414 (30%), Positives = 169/414 (40%), Gaps = 75/414 (18%)

Query: 14  FLRFPRPVRVVSGAEAELKCVV-LGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLT 72
           F + P  V V  G  A L+CV   G P P V W K G +L   E       G    L+++
Sbjct: 168 FRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGK---LMMS 224

Query: 73  AALPTDAGVYVCRARNAAGEAYAAAA-VTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
             L +DAG+YVC A N AGE  +AAA V VLE P+                       FL
Sbjct: 225 HTLKSDAGMYVCVASNMAGERESAAAEVMVLERPS-----------------------FL 261

Query: 132 TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEK-DGMALDEVWDSSHFALQPGRAEDGPGA 190
             P +Q VL  A V   C   G P P L W K DG             L  GR E     
Sbjct: 262 RRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDG------------ELPTGRYEIRSDH 309

Query: 191 SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
           SL +  ++A   D G Y C A N+ G A+A   L VH PP+      D+  AP       
Sbjct: 310 SLWIGHVSAE--DEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP------- 360

Query: 251 APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEG-RPLLPDRRRLMYRDR---DGGFVLKV 306
                    G+   F+C   G P P I W  EG + LL   + L    R        L +
Sbjct: 361 ---------GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411

Query: 307 LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAV------L 360
              Q  D G YVC A + AG  L+   L +K   L    P+  ++G  +   V      L
Sbjct: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPV-ILQGPANQTLVLGSSVWL 470

Query: 361 ECKVPNSRIPTAWFREDQRLL--PCRKYEQIEEGTVRRLIIHRLKADDDGIYLC 412
            C+V  +  P+  +++D + L     +++ +  GT   L I  ++  D G Y C
Sbjct: 471 PCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGT---LYIANVQEMDMGFYSC 521



 Score =  107 bits (266), Expect = 1e-22
 Identities = 92/328 (28%), Positives = 134/328 (40%), Gaps = 46/328 (14%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
           P FLR P    V++ A     C V G+PPP + W K   +L    R    +D   H L +
Sbjct: 258 PSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTG-RYEIRSD---HSLWI 313

Query: 72  TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
                 D G Y C A N+ G A A+ +++V  PP                         +
Sbjct: 314 GHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ-----------------------LV 350

Query: 132 TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQP-GRAEDGPGA 190
           T P+ Q    G  V   C   G P P ++W+K+G    +V      +LQP GR    P  
Sbjct: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEG---SQVLLFPSQSLQPTGRFSVSPRG 407

Query: 191 SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
              L I A +  D+G YVC A +  G   A ALL++        A  D  P  +++    
Sbjct: 408 Q--LNITAVQRGDAGYYVCQAVSVAGSILAKALLEI------KGASLDGLPPVILQ---- 455

Query: 251 APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
            P    +  G      C V G P+P + W  +G+ L  D   L ++    G  L +   Q
Sbjct: 456 GPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGD--DLQFKTMANG-TLYIANVQ 512

Query: 311 AKDRGLYVCAARNSAGQTLSAVQLHVKE 338
             D G Y C A++S G+   +  L ++E
Sbjct: 513 EMDMGFYSCVAKSSTGEATWSGWLKMRE 540



 Score =  105 bits (261), Expect = 5e-22
 Identities = 151/592 (25%), Positives = 219/592 (36%), Gaps = 128/592 (21%)

Query: 6   GDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGA 65
           G + + P  +  P  + V  G  A L C   G P P + W K G ++A         D  
Sbjct: 58  GPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVRE-----DPR 112

Query: 66  EHGLLLTAA------------LPTDAGVYVCRARN---AAGEAYAAAAVTVLEPPASDPE 110
            H LLL +                D GVY C ARN   AA    A+  V VL        
Sbjct: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDD----- 167

Query: 111 LQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTC-RAGGLPEPTLYWEKDGMALD 169
                              F   P +  V  G   VL C    G PEP++ W KDG  L 
Sbjct: 168 -------------------FRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLK 208

Query: 170 EVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQ-AGALLQVHQ 228
           E         + GR     G  +    L +   D+G+YVC A N  G  + A A + V +
Sbjct: 209 E---------EEGRITIRGGKLMMSHTLKS---DAGMYVCVASNMAGERESAAAEVMVLE 256

Query: 229 PP---ESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRP 285
            P     P      A APV                    F C V G P P + W  E   
Sbjct: 257 RPSFLRRPVNQVVLADAPVT-------------------FLCEVKGDPPPRLRWRKEDGE 297

Query: 286 LLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTR 345
            LP  R  +  D      L + +  A+D G Y C A NS G+  ++  L V  P    T+
Sbjct: 298 -LPTGRYEIRSDHS----LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQ 352

Query: 346 PLQDVEGREHGIAVLECKVPNSRIPTAWFRED---------QRLLPCRKYEQIEEGTVRR 396
           P   +      +A  +C+   +  P  +++++         Q L P  ++     G   +
Sbjct: 353 PQDQMAAPGESVA-FQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRG---Q 408

Query: 397 LIIHRLKADDDGIYLCE---MRGRVRTVANVTVKGPILKRLPRKLDVLEG-ENAVLLVET 452
           L I  ++  D G Y+C+   + G +   A + +KG  L  LP    +L+G  N  L++ +
Sbjct: 409 LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPV--ILQGPANQTLVLGS 466

Query: 453 ---LEAGVEG------RWSRDGEELP-VICQSSSGHMHALVLPGVTREDAG----EVTFS 498
              L   V G      RW +DG+ L     Q  +     L +  V   D G        S
Sbjct: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSS 526

Query: 499 LGNSRTTTLLRVK----------CVKHSPPGPPILAEMFKGHKNTVLLTWKP 540
            G +  +  L+++              SPPG P    + +  KN++ LTWKP
Sbjct: 527 TGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKP 578



 Score = 97.8 bits (242), Expect = 9e-20
 Identities = 103/360 (28%), Positives = 143/360 (39%), Gaps = 47/360 (13%)

Query: 105 PASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKD 164
           P  DP L  +       G  +  P  +  P    V RG    L CRA G P P + W K+
Sbjct: 46  PPGDPSLNGSR-----VGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKN 100

Query: 165 GMALDEVWDS--SHFALQPGRAEDGPGASLALRILAAR--LPDSGVYVCHARNAHGHAQA 220
           G  +  V +   +H  L P       GA    RI+  R   PD GVY C ARN  G A +
Sbjct: 101 GARVATVREDPRAHRLLLPS------GALFFPRIVHGRRARPDEGVYTCVARNYLGAAAS 154

Query: 221 -GALLQVHQPPESPPADPDEAPAPVVEP--LKCAPKTFWVNEGKHAKFRCYVMGKPEPEI 277
             A L+V    +     P      V EP  L+C P                  G PEP +
Sbjct: 155 RNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPP----------------RGHPEPSV 198

Query: 278 EWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLS-AVQLHV 336
            W  +G  L  +  R+  R    G  L + +    D G+YVC A N AG+  S A ++ V
Sbjct: 199 SWRKDGARLKEEEGRITIR----GGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMV 254

Query: 337 KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRR 396
            E      RP+  V   +  +  L C+V     P   +R++   LP  +YE   +     
Sbjct: 255 LERPSFLRRPVNQVVLADAPVTFL-CEVKGDPPPRLRWRKEDGELPTGRYEIRSD---HS 310

Query: 397 LIIHRLKADDDGIYLCEMR---GRVRTVANVTVK-GPILKRLPRKLDVLEGENAVLLVET 452
           L I  + A+D+G Y C      GR     +++V   P L   P+      GE+     ET
Sbjct: 311 LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCET 370



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 133/518 (25%), Positives = 205/518 (39%), Gaps = 92/518 (17%)

Query: 749  WYKDGQKVEESELLVVKMDGRKHRLILPEAKV------------QDSGEFECRTE---GV 793
            WYK+G +V       V+ D R HRL+LP   +             D G + C      G 
Sbjct: 97   WYKNGARVA-----TVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGA 151

Query: 794  SAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDR--EDAPVRWYKDGQEVEESD 851
            +A    +++   +     +    V     E  +L C   R   +  V W KDG  ++E +
Sbjct: 152  AASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEE 211

Query: 852  FVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-----ECAYFTVTITDVSSWIVYPSGKV 906
              +    G   +L++  T  SD G + CVA +     E A   V + +  S++  P  +V
Sbjct: 212  GRITIRGG---KLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQV 268

Query: 907  YVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDS 965
             +A      V   CE+   P   +RW K+  E+      +         L +  V  ED 
Sbjct: 269  VLADA---PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHS----LWIGHVSAEDE 321

Query: 966  GEYLCEIDDE----SASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-V 1020
            G Y C  ++      AS +++V  PP  +  P+D+   +A   E V   CE      P +
Sbjct: 322  GTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQ---MAAPGESVAFQCETKGNPPPAI 378

Query: 1021 RWYKDGLEVEESEALVLERDG-----PRCRLVLPAAQPEDGGEFVCD----AGDDSAFFT 1071
             W K+G +V    +  L+  G     PR +L + A Q  D G +VC     AG   A   
Sbjct: 379  FWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKAL 438

Query: 1072 VTVTA------PPERIVHPAARSLDLHFGAPGRVELRCEVA--PAGSQVRWYKDGLEVEA 1123
            + +        PP  +  PA ++L L       V L C V   P  S VRW KDG  ++ 
Sbjct: 439  LEIKGASLDGLPPVILQGPANQTLVL----GSSVWLPCRVTGNPQPS-VRWKKDGQWLQG 493

Query: 1124 SD-ALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA--ITFN---------VILAEPPV 1171
             D   +  A G   TL + + Q  D G Y C  +      T++          +  +PP 
Sbjct: 494  DDLQFKTMANG---TLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPP- 549

Query: 1172 QFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHN 1209
                  T PS    AP +PVV   E+++    + W  N
Sbjct: 550  ------TEPSSPPGAPSQPVV--TEITKNSITLTWKPN 579



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 117/460 (25%), Positives = 177/460 (38%), Gaps = 66/460 (14%)

Query: 924  RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQL------------EDSGEYLCE 971
            RP   + W K+G  V       ++++    RL+LP+  L             D G Y C 
Sbjct: 90   RPRPNIEWYKNGARVAT-----VREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCV 144

Query: 972  IDD---ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSR--EDAPVRWYKDG 1026
              +    +AS   ++    +R  + +    ++    E  VL C   R   +  V W KDG
Sbjct: 145  ARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDG 204

Query: 1027 LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGD-----DSAFFTVTVTAPPERI 1081
              ++E E  +  R G   +L++      D G +VC A +     +SA   V V   P  +
Sbjct: 205  ARLKEEEGRITIRGG---KLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFL 261

Query: 1082 VHPAARSLDLHFGAPGRVELRCEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTL 1140
              P  + +     A   V   CEV      ++RW K+  E+      ++ ++    +L +
Sbjct: 262  RRPVNQVVL----ADAPVTFLCEVKGDPPPRLRWRKEDGELPTG-RYEIRSD---HSLWI 313

Query: 1141 PHAQPEDAGEYVCETRHEA----ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCE 1196
             H   ED G Y C   +       + ++ +  PP     L T P     APGE V   CE
Sbjct: 314  GHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP----QLVTQPQDQMAAPGESVAFQCE 369

Query: 1197 LSRAGAPVV-WSHNGRPVQEGEGLELHAEG-----PRRVLCIQAAGPAHAGLYTCQSGAA 1250
                  P + W   G  V       L   G     PR  L I A     AG Y CQ+ + 
Sbjct: 370  TKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSV 429

Query: 1251 PGAPSLSFTVQV------AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWY 1303
             G+      +++        PPV +  P A QT V    G  + L   ++G P   VRW 
Sbjct: 430  AGSILAKALLEIKGASLDGLPPVILQGP-ANQTLVL---GSSVWLPCRVTGNPQPSVRWK 485

Query: 1304 KDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA 1343
            KDG+ L  QG     +  A   L +   +  D G Y C A
Sbjct: 486  KDGQWL--QGDDLQFKTMANGTLYIANVQEMDMGFYSCVA 523



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 87/374 (23%), Positives = 144/374 (38%), Gaps = 38/374 (10%)

Query: 1356 EPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVT-----PGPQVEMAQ 1409
            E  + ++V +   L V  G+ AT  C     P  ++ W +NGA V      P     +  
Sbjct: 60   EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLP 119

Query: 1410 NGS---SRILTLRGCQLGDAGTVTLRA-----GSTATSARLHVRETELLFLRRLQDVRAE 1461
            +G+    RI+  R  +  D G  T  A      + + +A L V      F +   +V   
Sbjct: 120  SGALFFPRIVHGRRAR-PDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA 178

Query: 1462 EGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYG 1521
             G+   LE    R     +V W + G  L  +      + G   +L +   + +D G Y 
Sbjct: 179  VGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGG---KLMMSHTLKSDAGMYV 235

Query: 1522 CESHH-----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTG-EWARG 1575
            C + +     +   A + V  R   + RP+  V +++    TF  E+  +      W + 
Sbjct: 236  CVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADA-PVTFLCEVKGDPPPRLRWRKE 294

Query: 1576 GVQLYPGPKCHIHSDGHRHRLVLNGLGLADSG---CVSFTADSLRCAARLIVREVPVTIV 1632
              +L P  +  I SD   H L +  +   D G   CV+  +     A+  +   VP  +V
Sbjct: 295  DGEL-PTGRYEIRSD---HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350

Query: 1633 RGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALG-----TRRLLQ 1686
              P D     G++  F+CE        + W+K+G+ +   P   LQ  G      R  L 
Sbjct: 351  TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLN 410

Query: 1687 LRRCGPSDAGTYSC 1700
            +      DAG Y C
Sbjct: 411  ITAVQRGDAGYYVC 424



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 81/274 (29%), Positives = 109/274 (39%), Gaps = 33/274 (12%)

Query: 1631 IVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTP---SPR-----LRLQALGT 1681
            IV  P DL V+ G+ AT  C    +   ++ W K+G  +      PR     L   AL  
Sbjct: 66   IVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFF 125

Query: 1682 RRLLQLRRCGPSDAGTYSCA----VGTARAGPVRLTVRERTVAVLSELRSVSAREGDGAT 1737
             R++  RR  P D G Y+C     +G A +    L V            +V    G+ A 
Sbjct: 126  PRIVHGRRARP-DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAV 184

Query: 1738 FECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHI----LVLSELRAEDAGE----VR 1789
             EC    V   G  E      + GAR++  +EG+  I    L++S     DAG       
Sbjct: 185  LEC----VPPRGHPEPSVSWRKDGARLK-EEEGRITIRGGKLMMSHTLKSDAGMYVCVAS 239

Query: 1790 FQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGG-HVCWLREGAEL 1848
              AG  +S A  EV  L        P  + VL          V       + W +E  EL
Sbjct: 240  NMAGERESAAA-EVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL 298

Query: 1849 CPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
             P  +YE+RS    HSL I  V  ED+GTY C A
Sbjct: 299  -PTGRYEIRSD---HSLWIGHVSAEDEGTYTCVA 328



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 42/128 (32%), Positives = 57/128 (44%), Gaps = 9/128 (7%)

Query: 1   MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 60
           +K +S D G PP  L+ P    +V G+   L C V G P P V W+K GQ L   + L F
Sbjct: 441 IKGASLD-GLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD-LQF 498

Query: 61  PADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPS 120
               A   L +      D G Y C A+++ GEA  +  + + E     P+      P   
Sbjct: 499 KT-MANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPD------PPTE 551

Query: 121 PGSGEGAP 128
           P S  GAP
Sbjct: 552 PSSPPGAP 559



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 63/250 (25%), Positives = 99/250 (39%), Gaps = 37/250 (14%)

Query: 654 LKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGA---LVGFSCPGVQDSAALTI 710
           L+  + +G++  G  RY I      H L +  V  +D G    +   S    + S +L++
Sbjct: 289 LRWRKEDGELPTG--RYEIRS---DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343

Query: 711 QESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGR 769
              P  +  PQD+++      E V   CE      PA  W K+G +V       ++  GR
Sbjct: 344 HVPPQLVTQPQDQMA---APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGR 400

Query: 770 -----KHRLILPEAKVQDSGEFECRTEGVSAFF---------GVTVQD-PPVHIVDPREH 814
                + +L +   +  D+G + C+   V+            G ++   PPV +  P   
Sbjct: 401 FSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ 460

Query: 815 VFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESD--FVVLENEGPHRRLVLPATQP 871
             V       V L C V     P VRW KDGQ ++  D  F  + N      L +   Q 
Sbjct: 461 TLV---LGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN----GTLYIANVQE 513

Query: 872 SDGGEFQCVA 881
            D G + CVA
Sbjct: 514 MDMGFYSCVA 523



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 100/387 (25%), Positives = 146/387 (37%), Gaps = 72/387 (18%)

Query: 1180 PSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPR----------- 1227
            P  L V+ GEP  L C       P + W  NG  V          E PR           
Sbjct: 70   PPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVR------EDPRAHRLLLPSGAL 123

Query: 1228 ---RVLCIQAAGPAHAGLYTCQSGAAPG-APSLSFTVQVAEPPVRVVAPEAAQTRVRSTP 1283
               R++  + A P   G+YTC +    G A S + +++VA            +   R +P
Sbjct: 124  FFPRIVHGRRARP-DEGVYTCVARNYLGAAASRNASLEVA----------VLRDDFRQSP 172

Query: 1284 G---------GDLELVVHLSGPGGPVRWYKDGERL-ASQGRVQLEQAGARQVLRVQGARS 1333
            G           LE V     P   V W KDG RL   +GR+ +   G +  L +     
Sbjct: 173  GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR--GGK--LMMSHTLK 228

Query: 1334 GDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSEL-TPLTVHEGDDA--TFRCEV-SPPDAD 1389
             DAG Y+C A   +     +  E ++++  S L  P+      DA  TF CEV   P   
Sbjct: 229  SDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR 288

Query: 1390 VTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVR 1445
            + W +    +  G + E+  + S   L +      D GT T  A    G    S  L V 
Sbjct: 289  LRWRKEDGELPTG-RYEIRSDHS---LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH 344

Query: 1446 ETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGG--------QPLPHDSRLS 1497
                L + + QD  A  G+ V  + ET +     A+ W + G        Q L    R S
Sbjct: 345  VPPQL-VTQPQDQMAAPGESVAFQCET-KGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFS 402

Query: 1498 MAQDGHIHRLFIHGVILADQGTYGCES 1524
            ++  G ++   I  V   D G Y C++
Sbjct: 403  VSPRGQLN---ITAVQRGDAGYYVCQA 426


>gi|46049110 myosin binding protein C, slow type isoform 4 [Homo
            sapiens]
          Length = 1123

 Score =  116 bits (291), Expect = 2e-25
 Identities = 130/532 (24%), Positives = 212/532 (39%), Gaps = 37/532 (6%)

Query: 1207 SHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
            S  G+ +Q  E  E H+      + I  A    AG Y C+        S SF ++V E  
Sbjct: 104  SKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHES- 162

Query: 1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVL 1326
                          +TP  D+      SG G       D   L  +  V+ +Q    QV 
Sbjct: 163  ------------TGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVK-QQEEEPQVD 209

Query: 1327 RVQGARSGDAGEYLCDAPQDS---------RIFLVSVEEPLLVKLVSELTPL-TVHEGDD 1376
              +  ++    EY   A Q           R+  +  EE         L P   V +G  
Sbjct: 210  VWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGR 269

Query: 1377 ATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGST 1436
              F  E++ P  +V W +NG  + P  +      G  RIL +  CQ+ D     + AG  
Sbjct: 270  VRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDE 329

Query: 1437 ATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPL--PHDS 1494
              S  L VRE  ++  ++L+D  A  G+ V LE E     A   V+W + G+ +     S
Sbjct: 330  KCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDA--NVKWFKNGEEIIPGPKS 387

Query: 1495 RLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEG 1554
            R  +  +G  H L I G   AD   Y   +   ++ A+LSV  + L++L PL D T++ G
Sbjct: 388  RYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLG 447

Query: 1555 GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTAD 1614
                 + E+S E + G+W + G+ +    +  +   G  H+LV+      D G   F  D
Sbjct: 448  KEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPD 506

Query: 1615 --SLRCAARLIVREVPVTIVRG---PHDLEVTEGDTATFECELS-QALADVTWEKDGNAL 1668
              ++   A++ V + P  I+ G    + + V  G+    E  +S +      W +   A+
Sbjct: 507  AYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAI 566

Query: 1669 TP-SPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTV 1719
               S R+R ++      L +      D+G Y   +    AG    +++ + V
Sbjct: 567  MEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKN-EAGEAHASIKVKVV 617



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/368 (26%), Positives = 159/368 (43%), Gaps = 12/368 (3%)

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
            RV    EL  P  EV+W K+G+E+  S   + + +   R L +   Q+ D  EY     D
Sbjct: 269  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 328

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEV--EES 1032
            E  S  + V EPP+ +    ++ T  A   E V L CE+S +DA V+W+K+G E+     
Sbjct: 329  EKCSTELFVREPPIMVTKQLEDTT--AYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 386

Query: 1033 EALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLH 1092
                +  +G +  L++  A   D  E+        +   ++V   P +I+ P     D  
Sbjct: 387  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLT---DQT 443

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                  + L+CE++      +W K+GL V+ SD L++  +G    L + +A  ED G+YV
Sbjct: 444  VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYV 502

Query: 1153 C--ETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHN 1209
               +  +  +   V + +PP   L      + + V  G  + L   +S    P  +WS  
Sbjct: 503  FAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 562

Query: 1210 GRPVQEGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVR 1268
             + + EG G +   +      L I  A    +G+Y        G    S  V+V + P  
Sbjct: 563  DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 622

Query: 1269 VVAPEAAQ 1276
             VAP   +
Sbjct: 623  PVAPTVTE 630



 Score =  113 bits (283), Expect = 2e-24
 Identities = 83/342 (24%), Positives = 146/342 (42%), Gaps = 22/342 (6%)

Query: 1551 ISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVS 1610
            + +GG   F +EL+   +  +W + G ++ P  K      G +  L +N   + D     
Sbjct: 264  VDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYY 323

Query: 1611 FTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTP 1670
             TA   +C+  L VRE P+ + +   D     G+    ECE+S+  A+V W K+G  + P
Sbjct: 324  VTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIP 383

Query: 1671 SP--RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV 1728
             P  R R++  G + +L +     +DA  YS  + T      +L+V  + + +L+ L   
Sbjct: 384  GPKSRYRIRVEGKKHILIIEGATKADAAEYS-VMTTGGQSSAKLSVDLKPLKILTPLTDQ 442

Query: 1729 SAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEV 1788
            +   G     +C +SE    G+W   G P++   R+++  +G+ H LV++    ED G+ 
Sbjct: 443  TVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 501

Query: 1789 RFQAGPAQSLALLEVEALPLQMCRHPPR----------EKTVLVGRRAVLEVTVS-RSGG 1837
             F           +V  +       PP+            TV+ G +  LE+ +S     
Sbjct: 502  VFAPDAYNVTLPAKVHVI------DPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 555

Query: 1838 HVCWLREGAELCPGD-KYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               W R    +  G  +    S+  + +LVI     +D G Y
Sbjct: 556  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVY 597



 Score =  112 bits (280), Expect = 3e-24
 Identities = 75/243 (30%), Positives = 115/243 (47%), Gaps = 7/243 (2%)

Query: 1639 EVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            +V +G    F  EL+    +V W K+G  + PS +   +  G +R+L +  C  +D   Y
Sbjct: 263  QVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 322

Query: 1699 SCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPL 1758
                G  +     L VRE  + V  +L   +A  G+    EC VSE +   +W   G  +
Sbjct: 323  YVTAGDEKCS-TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI 381

Query: 1759 RPG--ARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPR 1816
             PG  +R RIR EGKKHIL++      DA E        QS A L V+  PL++   P  
Sbjct: 382  IPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILT-PLT 440

Query: 1817 EKTVLVGRRAVLEVTVSRS-GGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQ 1875
            ++TV +G+   L+  +S +  G   W + G  +   D+ ++   G  H LVI +   ED+
Sbjct: 441  DQTVNLGKEICLKCEISENIPGK--WTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDE 498

Query: 1876 GTY 1878
            G Y
Sbjct: 499  GDY 501



 Score =  108 bits (270), Expect = 5e-23
 Identities = 92/328 (28%), Positives = 155/328 (47%), Gaps = 11/328 (3%)

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            V+WYK+GQE+  S   + E++G  R L +   Q +D  E+   AGDE     + + +   
Sbjct: 283  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPP- 341

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESP--ALLLQKEDTVRRL 955
             I+         A   ERV L CE+    A V+W K+GEE++  P     ++ E     L
Sbjct: 342  -IMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHIL 400

Query: 956  VLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSR 1015
            ++      D+ EY        +S  ++V   P++I+ P  + T+      C  L CE+S 
Sbjct: 401  IIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEIC--LKCEIS- 457

Query: 1016 EDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--DAGDDSAFFTVT 1073
            E+ P +W K+GL V+ES+ L +   G   +LV+  A  ED G++V   DA + +    V 
Sbjct: 458  ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVH 517

Query: 1074 VTAPPERIVH--PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
            V  PP+ I+    A  ++ +  G   R+E+     P    +    D   +E S  ++  +
Sbjct: 518  VIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTES 577

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETRHEA 1159
               + TL +  A+ +D+G Y    ++EA
Sbjct: 578  YPDSSTLVIDIAERDDSGVYHINLKNEA 605



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 86/365 (23%), Positives = 149/365 (40%), Gaps = 20/365 (5%)

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            RV    EL+       WYK+GQ++  S   + +  G +  L +   ++ D  E+      
Sbjct: 269  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 328

Query: 793  VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEV--EES 850
                  + V++PP+ +    E     A   E V L CEV  +DA V+W+K+G+E+     
Sbjct: 329  EKCSTELFVREPPIMVTKQLED--TTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 386

Query: 851  DFVVLENEGPHRRLVLPATQPSDGGEFQCV--AGDECAYFTVTITDVSSWIVYPSGKVYV 908
                +  EG    L++     +D  E+  +   G   A  +V +  +          V +
Sbjct: 387  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNL 446

Query: 909  AAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
                 + + L CE+       +WTK+G  V ES  L +  +  + +LV+     ED G+Y
Sbjct: 447  G----KEICLKCEISEN-IPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 501

Query: 969  LCEIDDESASF--TVTVTEPPVRIIYPRD-EVTLIAVTLECVVLMCELSREDAP-VRWYK 1024
            +   D  + +    V V +PP  I+   D + T+  +    + L   +S E  P   W +
Sbjct: 502  VFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSR 561

Query: 1025 DGLEVEESEALVLERDGP-RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPE 1079
                + E    +     P    LV+  A+ +D G +      +AG+  A   V V   P+
Sbjct: 562  GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPD 621

Query: 1080 RIVHP 1084
              V P
Sbjct: 622  PPVAP 626



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 85/358 (23%), Positives = 145/358 (40%), Gaps = 21/358 (5%)

Query: 1097 GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR 1156
            GRV    E+A    +V+WYK+G E+  S       +G  R L + + Q  D  EY     
Sbjct: 268  GRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAG 327

Query: 1157 HEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEG 1216
             E  +  + + EPP+         +  C   GE V L CE+S   A V W  NG  +  G
Sbjct: 328  DEKCSTELFVREPPIMVTKQLEDTTAYC---GERVELECEVSEDDANVKWFKNGEEIIPG 384

Query: 1217 --EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEA 1274
                  +  EG + +L I+ A  A A  Y+  +     +  LS  ++    P++++ P  
Sbjct: 385  PKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLK----PLKILTPLT 440

Query: 1275 AQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
             QT      G ++ L   +S    P +W K+G  +    R+++   G    L +  A + 
Sbjct: 441  DQT---VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTE 496

Query: 1335 DAGEYLCDAPQDSRIFL---VSVEEP--LLVKLVSELTPLTVHEGDDATFRCEVS-PPDA 1388
            D G+Y+  AP    + L   V V +P  +++  +     +TV  G+       +S  P  
Sbjct: 497  DEGDYVF-APDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 555

Query: 1389 DVTWLRNGAVVTPGP-QVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
               W R    +  G  ++       S  L +   +  D+G   +   + A  A   ++
Sbjct: 556  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIK 613



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 80/305 (26%), Positives = 126/305 (41%), Gaps = 32/305 (10%)

Query: 614 PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT-WFLNGEELKSNEPEGQVEPGALRYRI 672
           P   +   LED   Y GE      ++S       WF NGEE+        +     RYRI
Sbjct: 340 PPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI--------IPGPKSRYRI 391

Query: 673 EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
             +G +H LI+      D+ A       G Q SA L++   P+ IL+P      T    +
Sbjct: 392 RVEGKKHILIIEGATKADA-AEYSVMTTGGQSSAKLSVDLKPLKILTPL--TDQTVNLGK 448

Query: 733 RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            + L CE+S  + P  W K+G  V+ES+ L V   GR H+L++  A  +D G++    + 
Sbjct: 449 EICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA 507

Query: 793 VSAFFGVTVQDPPVHIVDPREHVF--------VHAITSECVMLACEVDREDAPVRWYKDG 844
               + VT+    VH++DP + +         V  I    + L   +  E  P   +  G
Sbjct: 508 ----YNVTL-PAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 562

Query: 845 QE--VEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSW 898
            +  +E S  +  E+      LV+   +  D G +       AG+  A   V + D    
Sbjct: 563 DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 622

Query: 899 IVYPS 903
            V P+
Sbjct: 623 PVAPT 627



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 63/257 (24%), Positives = 108/257 (42%), Gaps = 15/257 (5%)

Query: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
           K     + V++G   +F    +  P+ E++W+  G+ + P  + + +  +    +L +  
Sbjct: 256 KILDPAYQVDKGGRVRF-VVELADPKLEVKWYKNGQEIRPSTKYI-FEHKGCQRILFINN 313

Query: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
           CQ  D   Y      +AG    + +L V+EP +  T+ L+D          LEC+V    
Sbjct: 314 CQMTDDSEYYV----TAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 369

Query: 369 IPTAWFREDQRLLPCRK--YEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
               WF+  + ++P  K  Y    EG    LII      D   Y     G  ++ A ++V
Sbjct: 370 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGG-QSSAKLSV 428

Query: 427 KGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDG---EELPVICQSSSGHMHA 481
               LK L    D  V  G+   L  E  E  + G+W+++G   +E   +     G +H 
Sbjct: 429 DLKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHK 487

Query: 482 LVLPGVTREDAGEVTFS 498
           LV+     ED G+  F+
Sbjct: 488 LVIANALTEDEGDYVFA 504



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 71/325 (21%), Positives = 131/325 (40%), Gaps = 31/325 (9%)

Query: 260 GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGG--FVLKVLYCQAKDRGLY 317
           G+  +  C V  + +  ++W   G  ++P  +   YR R  G   +L +      D   Y
Sbjct: 356 GERVELECEV-SEDDANVKWFKNGEEIIPGPKS-RYRIRVEGKKHILIIEGATKADAAEY 413

Query: 318 VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
             +   + GQ  S+ +L V    L+   PL D          L+C++ +  IP  W +  
Sbjct: 414 --SVMTTGGQ--SSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEI-SENIPGKWTKNG 468

Query: 378 QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRK 437
             +    + + + +G + +L+I     +D+G Y+           NVT+   +    P K
Sbjct: 469 LPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVF-----APDAYNVTLPAKVHVIDPPK 523

Query: 438 --LDVLEGENAVLLVE----TLEAGVEGR------WSRDGEELPV----ICQSSSGHMHA 481
             LD L+ +N V ++      LE  + G       WSR  + +      I   S      
Sbjct: 524 IILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSST 583

Query: 482 LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
           LV+    R+D+G    +L N        +K      P PP+   + +   +  ++ W+PP
Sbjct: 584 LVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPP 643

Query: 542 EPAPETPFI-YRLERQEVGSEDWIQ 565
                +P + Y +ER++  S  W++
Sbjct: 644 AYDGGSPILGYFIERKKKQSSRWMR 668



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQ-LAASERLSFPADGAEHGLLLTAALPTDA 79
           V V++G +  L+  + GEPPP  +W +G +  +  S R+   +      L++  A   D+
Sbjct: 535 VTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDS 594

Query: 80  GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
           GVY    +N AGEA+A+  V V++ P  DP + P
Sbjct: 595 GVYHINLKNEAGEAHASIKVKVVDFP--DPPVAP 626



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 36/155 (23%), Positives = 64/155 (41%), Gaps = 8/155 (5%)

Query: 363 KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
           ++ + ++   W++  Q + P  KY    +G  R L I+  +  DD  Y     G  +   
Sbjct: 275 ELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV-TAGDEKCST 333

Query: 423 NVTVKGPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQSS----- 475
            + V+ P +    +  D     GE   L  E  E     +W ++GEE+    +S      
Sbjct: 334 ELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRV 393

Query: 476 SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRV 510
            G  H L++ G T+ DA E +      +++  L V
Sbjct: 394 EGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSV 428



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 70/314 (22%), Positives = 114/314 (36%), Gaps = 56/314 (17%)

Query: 26  GAEAELKCVVLGEPPPVVVWEKGGQQL--AASERLSFPADGAEHGLLLTAALPTDAGVYV 83
           G   EL+C V  E    V W K G+++      R     +G +H L++  A   DA  Y 
Sbjct: 356 GERVELECEV-SEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEY- 413

Query: 84  CRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGA 143
                  G++ A  +V          +L+P +               LT    Q V  G 
Sbjct: 414 -SVMTTGGQSSAKLSV----------DLKPLK--------------ILTPLTDQTVNLGK 448

Query: 144 EVVLTCRAG-GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLP 202
           E+ L C     +P     W K+G+ + E        +  GR          L I  A   
Sbjct: 449 EICLKCEISENIPGK---WTKNGLPVQE--SDRLKVVHKGRIHK-------LVIANALTE 496

Query: 203 DSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKH 262
           D G YV  A +A+          V  P +    DP   P  +++ L  A  T  V  G  
Sbjct: 497 DEGDYV-FAPDAYN---------VTLPAKVHVIDP---PKIILDGLD-ADNTVTVIAGNK 542

Query: 263 AKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
            +    + G+P P+  W    + ++    R+          L +   +  D G+Y    +
Sbjct: 543 LRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLK 602

Query: 323 NSAGQTLSAVQLHV 336
           N AG+  +++++ V
Sbjct: 603 NEAGEAHASIKVKV 616



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 1/78 (1%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G +A   C V G P+P+I W      ++ D R  M+ ++ G   L++      D G Y C
Sbjct: 1043 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQ-GVCTLEIRKPSPYDGGTYCC 1101

Query: 320  AARNSAGQTLSAVQLHVK 337
             A N  G      +L VK
Sbjct: 1102 KAVNDLGTVEIECKLEVK 1119



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 20/68 (29%), Positives = 28/68 (41%)

Query: 24   VSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYV 83
            ++G  A L C V G P P + W K    +    R    ++     L +    P D G Y 
Sbjct: 1041 IAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYC 1100

Query: 84   CRARNAAG 91
            C+A N  G
Sbjct: 1101 CKAVNDLG 1108



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 68/342 (19%), Positives = 125/342 (36%), Gaps = 48/342 (14%)

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQT 1277
            GL   A+   RV  + AAG +    Y+         P L    ++ EPP   +     QT
Sbjct: 781  GLPTDAKIFVRVKAVNAAGASEPKYYS--------QPIL--VKEIIEPPKIRIPRHLKQT 830

Query: 1278 RVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDA 1336
             +R   G  + LV+   G   P + W KDG  +  + ++ +  +    ++ ++ A    +
Sbjct: 831  YIRRV-GEAVNLVIPFQGKPRPELTWKKDGAEI-DKNQINIRNSETDTIIFIRKAERSHS 888

Query: 1337 GEYLCDAPQDSRIFLVSVE--------EPLLVKLVS---ELTPLT----VHEGDDATFRC 1381
            G+Y      D  +   S++         P +VK+     E   LT      +G+ A    
Sbjct: 889  GKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGY 948

Query: 1382 EVSPPDA-DVTWL-------RNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA 1433
             +   D   + W        R  A +T   ++ +      R+ +   C L +  T+T  +
Sbjct: 949  TIQKADKKSMEWFTVIEHYHRTSATIT---ELVIGNEYYFRVFSENMCGLSEDATMTKES 1005

Query: 1434 GSTATSARLHVRET--------ELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVR 1485
               A   +++              +F + L +  A  G +  L     R      + W++
Sbjct: 1006 AVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSV-RGNPKPKITWMK 1064

Query: 1486 GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD 1527
                +  D R  M  +  +  L I      D GTY C++ +D
Sbjct: 1065 NKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1106



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 1643 GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
            G  AT  C +       +TW K+  A+   PR R+ +      L++R+  P D GTY C
Sbjct: 1043 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCC 1101



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 15/47 (31%), Positives = 23/47 (48%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQD 1885
            + W++    +    +Y M S+    +L I    P D GTYCC+A  D
Sbjct: 1060 ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1106



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 5/77 (6%)

Query: 1374 GDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
            G +AT  C V   P   +TW++N   +   P+  M  N     L +R     D GT   +
Sbjct: 1043 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCK 1102

Query: 1433 A----GSTATSARLHVR 1445
            A    G+     +L V+
Sbjct: 1103 AVNDLGTVEIECKLEVK 1119



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 4/72 (5%)

Query: 34  VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEA 93
           V L +P   V W K GQ++  S +  F   G +  L +     TD   Y       AG+ 
Sbjct: 274 VELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV----TAGDE 329

Query: 94  YAAAAVTVLEPP 105
             +  + V EPP
Sbjct: 330 KCSTELFVREPP 341



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/55 (30%), Positives = 23/55 (41%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            V W + G E+ P  KY     G    L I++ +  D   Y   AG +   T L V
Sbjct: 283  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFV 337


>gi|46049119 myosin binding protein C, slow type isoform 3 [Homo
            sapiens]
          Length = 1141

 Score =  116 bits (291), Expect = 2e-25
 Identities = 130/532 (24%), Positives = 212/532 (39%), Gaps = 37/532 (6%)

Query: 1207 SHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
            S  G+ +Q  E  E H+      + I  A    AG Y C+        S SF ++V E  
Sbjct: 104  SKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHES- 162

Query: 1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVL 1326
                          +TP  D+      SG G       D   L  +  V+ +Q    QV 
Sbjct: 163  ------------TGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVK-QQEEEPQVD 209

Query: 1327 RVQGARSGDAGEYLCDAPQDS---------RIFLVSVEEPLLVKLVSELTPL-TVHEGDD 1376
              +  ++    EY   A Q           R+  +  EE         L P   V +G  
Sbjct: 210  VWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGR 269

Query: 1377 ATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGST 1436
              F  E++ P  +V W +NG  + P  +      G  RIL +  CQ+ D     + AG  
Sbjct: 270  VRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDE 329

Query: 1437 ATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPL--PHDS 1494
              S  L VRE  ++  ++L+D  A  G+ V LE E     A   V+W + G+ +     S
Sbjct: 330  KCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDA--NVKWFKNGEEIIPGPKS 387

Query: 1495 RLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEG 1554
            R  +  +G  H L I G   AD   Y   +   ++ A+LSV  + L++L PL D T++ G
Sbjct: 388  RYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLG 447

Query: 1555 GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTAD 1614
                 + E+S E + G+W + G+ +    +  +   G  H+LV+      D G   F  D
Sbjct: 448  KEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPD 506

Query: 1615 --SLRCAARLIVREVPVTIVRG---PHDLEVTEGDTATFECELS-QALADVTWEKDGNAL 1668
              ++   A++ V + P  I+ G    + + V  G+    E  +S +      W +   A+
Sbjct: 507  AYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAI 566

Query: 1669 TP-SPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTV 1719
               S R+R ++      L +      D+G Y   +    AG    +++ + V
Sbjct: 567  MEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKN-EAGEAHASIKVKVV 617



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/368 (26%), Positives = 159/368 (43%), Gaps = 12/368 (3%)

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
            RV    EL  P  EV+W K+G+E+  S   + + +   R L +   Q+ D  EY     D
Sbjct: 269  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 328

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEV--EES 1032
            E  S  + V EPP+ +    ++ T  A   E V L CE+S +DA V+W+K+G E+     
Sbjct: 329  EKCSTELFVREPPIMVTKQLEDTT--AYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 386

Query: 1033 EALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLH 1092
                +  +G +  L++  A   D  E+        +   ++V   P +I+ P     D  
Sbjct: 387  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLT---DQT 443

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                  + L+CE++      +W K+GL V+ SD L++  +G    L + +A  ED G+YV
Sbjct: 444  VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYV 502

Query: 1153 C--ETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHN 1209
               +  +  +   V + +PP   L      + + V  G  + L   +S    P  +WS  
Sbjct: 503  FAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 562

Query: 1210 GRPVQEGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVR 1268
             + + EG G +   +      L I  A    +G+Y        G    S  V+V + P  
Sbjct: 563  DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 622

Query: 1269 VVAPEAAQ 1276
             VAP   +
Sbjct: 623  PVAPTVTE 630



 Score =  113 bits (283), Expect = 2e-24
 Identities = 83/342 (24%), Positives = 146/342 (42%), Gaps = 22/342 (6%)

Query: 1551 ISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVS 1610
            + +GG   F +EL+   +  +W + G ++ P  K      G +  L +N   + D     
Sbjct: 264  VDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYY 323

Query: 1611 FTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTP 1670
             TA   +C+  L VRE P+ + +   D     G+    ECE+S+  A+V W K+G  + P
Sbjct: 324  VTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIP 383

Query: 1671 SP--RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV 1728
             P  R R++  G + +L +     +DA  YS  + T      +L+V  + + +L+ L   
Sbjct: 384  GPKSRYRIRVEGKKHILIIEGATKADAAEYS-VMTTGGQSSAKLSVDLKPLKILTPLTDQ 442

Query: 1729 SAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEV 1788
            +   G     +C +SE    G+W   G P++   R+++  +G+ H LV++    ED G+ 
Sbjct: 443  TVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 501

Query: 1789 RFQAGPAQSLALLEVEALPLQMCRHPPR----------EKTVLVGRRAVLEVTVS-RSGG 1837
             F           +V  +       PP+            TV+ G +  LE+ +S     
Sbjct: 502  VFAPDAYNVTLPAKVHVI------DPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 555

Query: 1838 HVCWLREGAELCPGD-KYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               W R    +  G  +    S+  + +LVI     +D G Y
Sbjct: 556  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVY 597



 Score =  112 bits (280), Expect = 3e-24
 Identities = 75/243 (30%), Positives = 115/243 (47%), Gaps = 7/243 (2%)

Query: 1639 EVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            +V +G    F  EL+    +V W K+G  + PS +   +  G +R+L +  C  +D   Y
Sbjct: 263  QVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 322

Query: 1699 SCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPL 1758
                G  +     L VRE  + V  +L   +A  G+    EC VSE +   +W   G  +
Sbjct: 323  YVTAGDEKCS-TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI 381

Query: 1759 RPG--ARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPR 1816
             PG  +R RIR EGKKHIL++      DA E        QS A L V+  PL++   P  
Sbjct: 382  IPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILT-PLT 440

Query: 1817 EKTVLVGRRAVLEVTVSRS-GGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQ 1875
            ++TV +G+   L+  +S +  G   W + G  +   D+ ++   G  H LVI +   ED+
Sbjct: 441  DQTVNLGKEICLKCEISENIPGK--WTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDE 498

Query: 1876 GTY 1878
            G Y
Sbjct: 499  GDY 501



 Score =  108 bits (270), Expect = 5e-23
 Identities = 92/328 (28%), Positives = 155/328 (47%), Gaps = 11/328 (3%)

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            V+WYK+GQE+  S   + E++G  R L +   Q +D  E+   AGDE     + + +   
Sbjct: 283  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPP- 341

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESP--ALLLQKEDTVRRL 955
             I+         A   ERV L CE+    A V+W K+GEE++  P     ++ E     L
Sbjct: 342  -IMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHIL 400

Query: 956  VLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSR 1015
            ++      D+ EY        +S  ++V   P++I+ P  + T+      C  L CE+S 
Sbjct: 401  IIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEIC--LKCEIS- 457

Query: 1016 EDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--DAGDDSAFFTVT 1073
            E+ P +W K+GL V+ES+ L +   G   +LV+  A  ED G++V   DA + +    V 
Sbjct: 458  ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVH 517

Query: 1074 VTAPPERIVH--PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
            V  PP+ I+    A  ++ +  G   R+E+     P    +    D   +E S  ++  +
Sbjct: 518  VIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTES 577

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETRHEA 1159
               + TL +  A+ +D+G Y    ++EA
Sbjct: 578  YPDSSTLVIDIAERDDSGVYHINLKNEA 605



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 86/365 (23%), Positives = 149/365 (40%), Gaps = 20/365 (5%)

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            RV    EL+       WYK+GQ++  S   + +  G +  L +   ++ D  E+      
Sbjct: 269  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 328

Query: 793  VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEV--EES 850
                  + V++PP+ +    E     A   E V L CEV  +DA V+W+K+G+E+     
Sbjct: 329  EKCSTELFVREPPIMVTKQLED--TTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 386

Query: 851  DFVVLENEGPHRRLVLPATQPSDGGEFQCV--AGDECAYFTVTITDVSSWIVYPSGKVYV 908
                +  EG    L++     +D  E+  +   G   A  +V +  +          V +
Sbjct: 387  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNL 446

Query: 909  AAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
                 + + L CE+       +WTK+G  V ES  L +  +  + +LV+     ED G+Y
Sbjct: 447  G----KEICLKCEISEN-IPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 501

Query: 969  LCEIDDESASF--TVTVTEPPVRIIYPRD-EVTLIAVTLECVVLMCELSREDAP-VRWYK 1024
            +   D  + +    V V +PP  I+   D + T+  +    + L   +S E  P   W +
Sbjct: 502  VFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSR 561

Query: 1025 DGLEVEESEALVLERDGP-RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPE 1079
                + E    +     P    LV+  A+ +D G +      +AG+  A   V V   P+
Sbjct: 562  GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPD 621

Query: 1080 RIVHP 1084
              V P
Sbjct: 622  PPVAP 626



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 85/358 (23%), Positives = 145/358 (40%), Gaps = 21/358 (5%)

Query: 1097 GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR 1156
            GRV    E+A    +V+WYK+G E+  S       +G  R L + + Q  D  EY     
Sbjct: 268  GRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAG 327

Query: 1157 HEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEG 1216
             E  +  + + EPP+         +  C   GE V L CE+S   A V W  NG  +  G
Sbjct: 328  DEKCSTELFVREPPIMVTKQLEDTTAYC---GERVELECEVSEDDANVKWFKNGEEIIPG 384

Query: 1217 --EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEA 1274
                  +  EG + +L I+ A  A A  Y+  +     +  LS  ++    P++++ P  
Sbjct: 385  PKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLK----PLKILTPLT 440

Query: 1275 AQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
             QT      G ++ L   +S    P +W K+G  +    R+++   G    L +  A + 
Sbjct: 441  DQT---VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTE 496

Query: 1335 DAGEYLCDAPQDSRIFL---VSVEEP--LLVKLVSELTPLTVHEGDDATFRCEVS-PPDA 1388
            D G+Y+  AP    + L   V V +P  +++  +     +TV  G+       +S  P  
Sbjct: 497  DEGDYVF-APDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 555

Query: 1389 DVTWLRNGAVVTPGP-QVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
               W R    +  G  ++       S  L +   +  D+G   +   + A  A   ++
Sbjct: 556  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIK 613



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 80/305 (26%), Positives = 126/305 (41%), Gaps = 32/305 (10%)

Query: 614 PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT-WFLNGEELKSNEPEGQVEPGALRYRI 672
           P   +   LED   Y GE      ++S       WF NGEE+        +     RYRI
Sbjct: 340 PPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI--------IPGPKSRYRI 391

Query: 673 EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
             +G +H LI+      D+ A       G Q SA L++   P+ IL+P      T    +
Sbjct: 392 RVEGKKHILIIEGATKADA-AEYSVMTTGGQSSAKLSVDLKPLKILTPL--TDQTVNLGK 448

Query: 733 RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            + L CE+S  + P  W K+G  V+ES+ L V   GR H+L++  A  +D G++    + 
Sbjct: 449 EICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA 507

Query: 793 VSAFFGVTVQDPPVHIVDPREHVF--------VHAITSECVMLACEVDREDAPVRWYKDG 844
               + VT+    VH++DP + +         V  I    + L   +  E  P   +  G
Sbjct: 508 ----YNVTL-PAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 562

Query: 845 QE--VEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSW 898
            +  +E S  +  E+      LV+   +  D G +       AG+  A   V + D    
Sbjct: 563 DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 622

Query: 899 IVYPS 903
            V P+
Sbjct: 623 PVAPT 627



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 63/257 (24%), Positives = 108/257 (42%), Gaps = 15/257 (5%)

Query: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
           K     + V++G   +F    +  P+ E++W+  G+ + P  + + +  +    +L +  
Sbjct: 256 KILDPAYQVDKGGRVRF-VVELADPKLEVKWYKNGQEIRPSTKYI-FEHKGCQRILFINN 313

Query: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
           CQ  D   Y      +AG    + +L V+EP +  T+ L+D          LEC+V    
Sbjct: 314 CQMTDDSEYYV----TAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 369

Query: 369 IPTAWFREDQRLLPCRK--YEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
               WF+  + ++P  K  Y    EG    LII      D   Y     G  ++ A ++V
Sbjct: 370 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGG-QSSAKLSV 428

Query: 427 KGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDG---EELPVICQSSSGHMHA 481
               LK L    D  V  G+   L  E  E  + G+W+++G   +E   +     G +H 
Sbjct: 429 DLKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHK 487

Query: 482 LVLPGVTREDAGEVTFS 498
           LV+     ED G+  F+
Sbjct: 488 LVIANALTEDEGDYVFA 504



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 71/325 (21%), Positives = 131/325 (40%), Gaps = 31/325 (9%)

Query: 260 GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGG--FVLKVLYCQAKDRGLY 317
           G+  +  C V  + +  ++W   G  ++P  +   YR R  G   +L +      D   Y
Sbjct: 356 GERVELECEV-SEDDANVKWFKNGEEIIPGPKS-RYRIRVEGKKHILIIEGATKADAAEY 413

Query: 318 VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
             +   + GQ  S+ +L V    L+   PL D          L+C++ +  IP  W +  
Sbjct: 414 --SVMTTGGQ--SSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEI-SENIPGKWTKNG 468

Query: 378 QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRK 437
             +    + + + +G + +L+I     +D+G Y+           NVT+   +    P K
Sbjct: 469 LPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVF-----APDAYNVTLPAKVHVIDPPK 523

Query: 438 --LDVLEGENAVLLVE----TLEAGVEGR------WSRDGEELPV----ICQSSSGHMHA 481
             LD L+ +N V ++      LE  + G       WSR  + +      I   S      
Sbjct: 524 IILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSST 583

Query: 482 LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
           LV+    R+D+G    +L N        +K      P PP+   + +   +  ++ W+PP
Sbjct: 584 LVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPP 643

Query: 542 EPAPETPFI-YRLERQEVGSEDWIQ 565
                +P + Y +ER++  S  W++
Sbjct: 644 AYDGGSPILGYFIERKKKQSSRWMR 668



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQ-LAASERLSFPADGAEHGLLLTAALPTDA 79
           V V++G +  L+  + GEPPP  +W +G +  +  S R+   +      L++  A   D+
Sbjct: 535 VTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDS 594

Query: 80  GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
           GVY    +N AGEA+A+  V V++ P  DP + P
Sbjct: 595 GVYHINLKNEAGEAHASIKVKVVDFP--DPPVAP 626



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 36/155 (23%), Positives = 64/155 (41%), Gaps = 8/155 (5%)

Query: 363 KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
           ++ + ++   W++  Q + P  KY    +G  R L I+  +  DD  Y     G  +   
Sbjct: 275 ELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV-TAGDEKCST 333

Query: 423 NVTVKGPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQSS----- 475
            + V+ P +    +  D     GE   L  E  E     +W ++GEE+    +S      
Sbjct: 334 ELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRV 393

Query: 476 SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRV 510
            G  H L++ G T+ DA E +      +++  L V
Sbjct: 394 EGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSV 428



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 70/314 (22%), Positives = 114/314 (36%), Gaps = 56/314 (17%)

Query: 26  GAEAELKCVVLGEPPPVVVWEKGGQQL--AASERLSFPADGAEHGLLLTAALPTDAGVYV 83
           G   EL+C V  E    V W K G+++      R     +G +H L++  A   DA  Y 
Sbjct: 356 GERVELECEV-SEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEY- 413

Query: 84  CRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGA 143
                  G++ A  +V          +L+P +               LT    Q V  G 
Sbjct: 414 -SVMTTGGQSSAKLSV----------DLKPLK--------------ILTPLTDQTVNLGK 448

Query: 144 EVVLTCRAG-GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLP 202
           E+ L C     +P     W K+G+ + E        +  GR          L I  A   
Sbjct: 449 EICLKCEISENIPGK---WTKNGLPVQE--SDRLKVVHKGRIHK-------LVIANALTE 496

Query: 203 DSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKH 262
           D G YV  A +A+          V  P +    DP   P  +++ L  A  T  V  G  
Sbjct: 497 DEGDYV-FAPDAYN---------VTLPAKVHVIDP---PKIILDGLD-ADNTVTVIAGNK 542

Query: 263 AKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
            +    + G+P P+  W    + ++    R+          L +   +  D G+Y    +
Sbjct: 543 LRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLK 602

Query: 323 NSAGQTLSAVQLHV 336
           N AG+  +++++ V
Sbjct: 603 NEAGEAHASIKVKV 616



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 1/78 (1%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G +A   C V G P+P+I W      ++ D R  M+ ++ G   L++      D G Y C
Sbjct: 1061 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQ-GVCTLEIRKPSPYDGGTYCC 1119

Query: 320  AARNSAGQTLSAVQLHVK 337
             A N  G      +L VK
Sbjct: 1120 KAVNDLGTVEIECKLEVK 1137



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 20/68 (29%), Positives = 28/68 (41%)

Query: 24   VSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYV 83
            ++G  A L C V G P P + W K    +    R    ++     L +    P D G Y 
Sbjct: 1059 IAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYC 1118

Query: 84   CRARNAAG 91
            C+A N  G
Sbjct: 1119 CKAVNDLG 1126



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 68/342 (19%), Positives = 125/342 (36%), Gaps = 48/342 (14%)

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQT 1277
            GL   A+   RV  + AAG +    Y+         P L    ++ EPP   +     QT
Sbjct: 799  GLPTDAKIFVRVKAVNAAGASEPKYYS--------QPIL--VKEIIEPPKIRIPRHLKQT 848

Query: 1278 RVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDA 1336
             +R   G  + LV+   G   P + W KDG  +  + ++ +  +    ++ ++ A    +
Sbjct: 849  YIRRV-GEAVNLVIPFQGKPRPELTWKKDGAEI-DKNQINIRNSETDTIIFIRKAERSHS 906

Query: 1337 GEYLCDAPQDSRIFLVSVE--------EPLLVKLVS---ELTPLT----VHEGDDATFRC 1381
            G+Y      D  +   S++         P +VK+     E   LT      +G+ A    
Sbjct: 907  GKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGY 966

Query: 1382 EVSPPDA-DVTWL-------RNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA 1433
             +   D   + W        R  A +T   ++ +      R+ +   C L +  T+T  +
Sbjct: 967  TIQKADKKSMEWFTVIEHYHRTSATIT---ELVIGNEYYFRVFSENMCGLSEDATMTKES 1023

Query: 1434 GSTATSARLHVRET--------ELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVR 1485
               A   +++              +F + L +  A  G +  L     R      + W++
Sbjct: 1024 AVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSV-RGNPKPKITWMK 1082

Query: 1486 GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD 1527
                +  D R  M  +  +  L I      D GTY C++ +D
Sbjct: 1083 NKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1124



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 1643 GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
            G  AT  C +       +TW K+  A+   PR R+ +      L++R+  P D GTY C
Sbjct: 1061 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCC 1119



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 15/47 (31%), Positives = 23/47 (48%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQD 1885
            + W++    +    +Y M S+    +L I    P D GTYCC+A  D
Sbjct: 1078 ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1124



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 5/77 (6%)

Query: 1374 GDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
            G +AT  C V   P   +TW++N   +   P+  M  N     L +R     D GT   +
Sbjct: 1061 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCK 1120

Query: 1433 A----GSTATSARLHVR 1445
            A    G+     +L V+
Sbjct: 1121 AVNDLGTVEIECKLEVK 1137



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 4/72 (5%)

Query: 34  VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEA 93
           V L +P   V W K GQ++  S +  F   G +  L +     TD   Y       AG+ 
Sbjct: 274 VELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV----TAGDE 329

Query: 94  YAAAAVTVLEPP 105
             +  + V EPP
Sbjct: 330 KCSTELFVREPP 341



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/55 (30%), Positives = 23/55 (41%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            V W + G E+ P  KY     G    L I++ +  D   Y   AG +   T L V
Sbjct: 283  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFV 337


>gi|46049125 myosin binding protein C, slow type isoform 2 [Homo
            sapiens]
          Length = 1148

 Score =  116 bits (291), Expect = 2e-25
 Identities = 130/532 (24%), Positives = 212/532 (39%), Gaps = 37/532 (6%)

Query: 1207 SHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
            S  G+ +Q  E  E H+      + I  A    AG Y C+        S SF ++V E  
Sbjct: 129  SKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHES- 187

Query: 1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVL 1326
                          +TP  D+      SG G       D   L  +  V+ +Q    QV 
Sbjct: 188  ------------TGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVK-QQEEEPQVD 234

Query: 1327 RVQGARSGDAGEYLCDAPQDS---------RIFLVSVEEPLLVKLVSELTPL-TVHEGDD 1376
              +  ++    EY   A Q           R+  +  EE         L P   V +G  
Sbjct: 235  VWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGR 294

Query: 1377 ATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGST 1436
              F  E++ P  +V W +NG  + P  +      G  RIL +  CQ+ D     + AG  
Sbjct: 295  VRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDE 354

Query: 1437 ATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPL--PHDS 1494
              S  L VRE  ++  ++L+D  A  G+ V LE E     A   V+W + G+ +     S
Sbjct: 355  KCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDA--NVKWFKNGEEIIPGPKS 412

Query: 1495 RLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEG 1554
            R  +  +G  H L I G   AD   Y   +   ++ A+LSV  + L++L PL D T++ G
Sbjct: 413  RYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLG 472

Query: 1555 GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTAD 1614
                 + E+S E + G+W + G+ +    +  +   G  H+LV+      D G   F  D
Sbjct: 473  KEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPD 531

Query: 1615 --SLRCAARLIVREVPVTIVRG---PHDLEVTEGDTATFECELS-QALADVTWEKDGNAL 1668
              ++   A++ V + P  I+ G    + + V  G+    E  +S +      W +   A+
Sbjct: 532  AYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAI 591

Query: 1669 TP-SPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTV 1719
               S R+R ++      L +      D+G Y   +    AG    +++ + V
Sbjct: 592  MEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKN-EAGEAHASIKVKVV 642



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/368 (26%), Positives = 159/368 (43%), Gaps = 12/368 (3%)

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
            RV    EL  P  EV+W K+G+E+  S   + + +   R L +   Q+ D  EY     D
Sbjct: 294  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 353

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEV--EES 1032
            E  S  + V EPP+ +    ++ T  A   E V L CE+S +DA V+W+K+G E+     
Sbjct: 354  EKCSTELFVREPPIMVTKQLEDTT--AYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 411

Query: 1033 EALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLH 1092
                +  +G +  L++  A   D  E+        +   ++V   P +I+ P     D  
Sbjct: 412  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLT---DQT 468

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                  + L+CE++      +W K+GL V+ SD L++  +G    L + +A  ED G+YV
Sbjct: 469  VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYV 527

Query: 1153 C--ETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHN 1209
               +  +  +   V + +PP   L      + + V  G  + L   +S    P  +WS  
Sbjct: 528  FAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 587

Query: 1210 GRPVQEGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVR 1268
             + + EG G +   +      L I  A    +G+Y        G    S  V+V + P  
Sbjct: 588  DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 647

Query: 1269 VVAPEAAQ 1276
             VAP   +
Sbjct: 648  PVAPTVTE 655



 Score =  113 bits (283), Expect = 2e-24
 Identities = 83/342 (24%), Positives = 146/342 (42%), Gaps = 22/342 (6%)

Query: 1551 ISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVS 1610
            + +GG   F +EL+   +  +W + G ++ P  K      G +  L +N   + D     
Sbjct: 289  VDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYY 348

Query: 1611 FTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTP 1670
             TA   +C+  L VRE P+ + +   D     G+    ECE+S+  A+V W K+G  + P
Sbjct: 349  VTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIP 408

Query: 1671 SP--RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV 1728
             P  R R++  G + +L +     +DA  YS  + T      +L+V  + + +L+ L   
Sbjct: 409  GPKSRYRIRVEGKKHILIIEGATKADAAEYS-VMTTGGQSSAKLSVDLKPLKILTPLTDQ 467

Query: 1729 SAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEV 1788
            +   G     +C +SE    G+W   G P++   R+++  +G+ H LV++    ED G+ 
Sbjct: 468  TVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 526

Query: 1789 RFQAGPAQSLALLEVEALPLQMCRHPPR----------EKTVLVGRRAVLEVTVS-RSGG 1837
             F           +V  +       PP+            TV+ G +  LE+ +S     
Sbjct: 527  VFAPDAYNVTLPAKVHVI------DPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 580

Query: 1838 HVCWLREGAELCPGD-KYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               W R    +  G  +    S+  + +LVI     +D G Y
Sbjct: 581  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVY 622



 Score =  112 bits (280), Expect = 3e-24
 Identities = 75/243 (30%), Positives = 115/243 (47%), Gaps = 7/243 (2%)

Query: 1639 EVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            +V +G    F  EL+    +V W K+G  + PS +   +  G +R+L +  C  +D   Y
Sbjct: 288  QVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 347

Query: 1699 SCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPL 1758
                G  +     L VRE  + V  +L   +A  G+    EC VSE +   +W   G  +
Sbjct: 348  YVTAGDEKCS-TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI 406

Query: 1759 RPG--ARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPR 1816
             PG  +R RIR EGKKHIL++      DA E        QS A L V+  PL++   P  
Sbjct: 407  IPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILT-PLT 465

Query: 1817 EKTVLVGRRAVLEVTVSRS-GGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQ 1875
            ++TV +G+   L+  +S +  G   W + G  +   D+ ++   G  H LVI +   ED+
Sbjct: 466  DQTVNLGKEICLKCEISENIPGK--WTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDE 523

Query: 1876 GTY 1878
            G Y
Sbjct: 524  GDY 526



 Score =  108 bits (270), Expect = 5e-23
 Identities = 92/328 (28%), Positives = 155/328 (47%), Gaps = 11/328 (3%)

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            V+WYK+GQE+  S   + E++G  R L +   Q +D  E+   AGDE     + + +   
Sbjct: 308  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPP- 366

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESP--ALLLQKEDTVRRL 955
             I+         A   ERV L CE+    A V+W K+GEE++  P     ++ E     L
Sbjct: 367  -IMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHIL 425

Query: 956  VLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSR 1015
            ++      D+ EY        +S  ++V   P++I+ P  + T+      C  L CE+S 
Sbjct: 426  IIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEIC--LKCEIS- 482

Query: 1016 EDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--DAGDDSAFFTVT 1073
            E+ P +W K+GL V+ES+ L +   G   +LV+  A  ED G++V   DA + +    V 
Sbjct: 483  ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVH 542

Query: 1074 VTAPPERIVH--PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
            V  PP+ I+    A  ++ +  G   R+E+     P    +    D   +E S  ++  +
Sbjct: 543  VIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTES 602

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETRHEA 1159
               + TL +  A+ +D+G Y    ++EA
Sbjct: 603  YPDSSTLVIDIAERDDSGVYHINLKNEA 630



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 86/365 (23%), Positives = 149/365 (40%), Gaps = 20/365 (5%)

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            RV    EL+       WYK+GQ++  S   + +  G +  L +   ++ D  E+      
Sbjct: 294  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 353

Query: 793  VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEV--EES 850
                  + V++PP+ +    E     A   E V L CEV  +DA V+W+K+G+E+     
Sbjct: 354  EKCSTELFVREPPIMVTKQLED--TTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 411

Query: 851  DFVVLENEGPHRRLVLPATQPSDGGEFQCV--AGDECAYFTVTITDVSSWIVYPSGKVYV 908
                +  EG    L++     +D  E+  +   G   A  +V +  +          V +
Sbjct: 412  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNL 471

Query: 909  AAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
                 + + L CE+       +WTK+G  V ES  L +  +  + +LV+     ED G+Y
Sbjct: 472  G----KEICLKCEISEN-IPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 526

Query: 969  LCEIDDESASF--TVTVTEPPVRIIYPRD-EVTLIAVTLECVVLMCELSREDAP-VRWYK 1024
            +   D  + +    V V +PP  I+   D + T+  +    + L   +S E  P   W +
Sbjct: 527  VFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSR 586

Query: 1025 DGLEVEESEALVLERDGP-RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPE 1079
                + E    +     P    LV+  A+ +D G +      +AG+  A   V V   P+
Sbjct: 587  GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPD 646

Query: 1080 RIVHP 1084
              V P
Sbjct: 647  PPVAP 651



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 85/358 (23%), Positives = 145/358 (40%), Gaps = 21/358 (5%)

Query: 1097 GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR 1156
            GRV    E+A    +V+WYK+G E+  S       +G  R L + + Q  D  EY     
Sbjct: 293  GRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAG 352

Query: 1157 HEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEG 1216
             E  +  + + EPP+         +  C   GE V L CE+S   A V W  NG  +  G
Sbjct: 353  DEKCSTELFVREPPIMVTKQLEDTTAYC---GERVELECEVSEDDANVKWFKNGEEIIPG 409

Query: 1217 --EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEA 1274
                  +  EG + +L I+ A  A A  Y+  +     +  LS  ++    P++++ P  
Sbjct: 410  PKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLK----PLKILTPLT 465

Query: 1275 AQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
             QT      G ++ L   +S    P +W K+G  +    R+++   G    L +  A + 
Sbjct: 466  DQT---VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTE 521

Query: 1335 DAGEYLCDAPQDSRIFL---VSVEEP--LLVKLVSELTPLTVHEGDDATFRCEVS-PPDA 1388
            D G+Y+  AP    + L   V V +P  +++  +     +TV  G+       +S  P  
Sbjct: 522  DEGDYVF-APDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 580

Query: 1389 DVTWLRNGAVVTPGP-QVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
               W R    +  G  ++       S  L +   +  D+G   +   + A  A   ++
Sbjct: 581  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIK 638



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 80/305 (26%), Positives = 126/305 (41%), Gaps = 32/305 (10%)

Query: 614 PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT-WFLNGEELKSNEPEGQVEPGALRYRI 672
           P   +   LED   Y GE      ++S       WF NGEE+        +     RYRI
Sbjct: 365 PPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI--------IPGPKSRYRI 416

Query: 673 EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
             +G +H LI+      D+ A       G Q SA L++   P+ IL+P      T    +
Sbjct: 417 RVEGKKHILIIEGATKADA-AEYSVMTTGGQSSAKLSVDLKPLKILTPL--TDQTVNLGK 473

Query: 733 RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            + L CE+S  + P  W K+G  V+ES+ L V   GR H+L++  A  +D G++    + 
Sbjct: 474 EICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA 532

Query: 793 VSAFFGVTVQDPPVHIVDPREHVF--------VHAITSECVMLACEVDREDAPVRWYKDG 844
               + VT+    VH++DP + +         V  I    + L   +  E  P   +  G
Sbjct: 533 ----YNVTL-PAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 587

Query: 845 QE--VEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSW 898
            +  +E S  +  E+      LV+   +  D G +       AG+  A   V + D    
Sbjct: 588 DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 647

Query: 899 IVYPS 903
            V P+
Sbjct: 648 PVAPT 652



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 63/257 (24%), Positives = 108/257 (42%), Gaps = 15/257 (5%)

Query: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
           K     + V++G   +F    +  P+ E++W+  G+ + P  + + +  +    +L +  
Sbjct: 281 KILDPAYQVDKGGRVRF-VVELADPKLEVKWYKNGQEIRPSTKYI-FEHKGCQRILFINN 338

Query: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
           CQ  D   Y      +AG    + +L V+EP +  T+ L+D          LEC+V    
Sbjct: 339 CQMTDDSEYYV----TAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 394

Query: 369 IPTAWFREDQRLLPCRK--YEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
               WF+  + ++P  K  Y    EG    LII      D   Y     G  ++ A ++V
Sbjct: 395 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGG-QSSAKLSV 453

Query: 427 KGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDG---EELPVICQSSSGHMHA 481
               LK L    D  V  G+   L  E  E  + G+W+++G   +E   +     G +H 
Sbjct: 454 DLKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHK 512

Query: 482 LVLPGVTREDAGEVTFS 498
           LV+     ED G+  F+
Sbjct: 513 LVIANALTEDEGDYVFA 529



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 71/325 (21%), Positives = 131/325 (40%), Gaps = 31/325 (9%)

Query: 260 GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGG--FVLKVLYCQAKDRGLY 317
           G+  +  C V  + +  ++W   G  ++P  +   YR R  G   +L +      D   Y
Sbjct: 381 GERVELECEV-SEDDANVKWFKNGEEIIPGPKS-RYRIRVEGKKHILIIEGATKADAAEY 438

Query: 318 VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
             +   + GQ  S+ +L V    L+   PL D          L+C++ +  IP  W +  
Sbjct: 439 --SVMTTGGQ--SSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEI-SENIPGKWTKNG 493

Query: 378 QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRK 437
             +    + + + +G + +L+I     +D+G Y+           NVT+   +    P K
Sbjct: 494 LPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVF-----APDAYNVTLPAKVHVIDPPK 548

Query: 438 --LDVLEGENAVLLVE----TLEAGVEGR------WSRDGEELPV----ICQSSSGHMHA 481
             LD L+ +N V ++      LE  + G       WSR  + +      I   S      
Sbjct: 549 IILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSST 608

Query: 482 LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
           LV+    R+D+G    +L N        +K      P PP+   + +   +  ++ W+PP
Sbjct: 609 LVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPP 668

Query: 542 EPAPETPFI-YRLERQEVGSEDWIQ 565
                +P + Y +ER++  S  W++
Sbjct: 669 AYDGGSPILGYFIERKKKQSSRWMR 693



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQ-LAASERLSFPADGAEHGLLLTAALPTDA 79
           V V++G +  L+  + GEPPP  +W +G +  +  S R+   +      L++  A   D+
Sbjct: 560 VTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDS 619

Query: 80  GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
           GVY    +N AGEA+A+  V V++ P  DP + P
Sbjct: 620 GVYHINLKNEAGEAHASIKVKVVDFP--DPPVAP 651



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 36/155 (23%), Positives = 64/155 (41%), Gaps = 8/155 (5%)

Query: 363 KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
           ++ + ++   W++  Q + P  KY    +G  R L I+  +  DD  Y     G  +   
Sbjct: 300 ELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV-TAGDEKCST 358

Query: 423 NVTVKGPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQSS----- 475
            + V+ P +    +  D     GE   L  E  E     +W ++GEE+    +S      
Sbjct: 359 ELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRV 418

Query: 476 SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRV 510
            G  H L++ G T+ DA E +      +++  L V
Sbjct: 419 EGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSV 453



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 70/314 (22%), Positives = 114/314 (36%), Gaps = 56/314 (17%)

Query: 26  GAEAELKCVVLGEPPPVVVWEKGGQQL--AASERLSFPADGAEHGLLLTAALPTDAGVYV 83
           G   EL+C V  E    V W K G+++      R     +G +H L++  A   DA  Y 
Sbjct: 381 GERVELECEV-SEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEY- 438

Query: 84  CRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGA 143
                  G++ A  +V          +L+P +               LT    Q V  G 
Sbjct: 439 -SVMTTGGQSSAKLSV----------DLKPLK--------------ILTPLTDQTVNLGK 473

Query: 144 EVVLTCRAG-GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLP 202
           E+ L C     +P     W K+G+ + E        +  GR          L I  A   
Sbjct: 474 EICLKCEISENIPGK---WTKNGLPVQE--SDRLKVVHKGRIHK-------LVIANALTE 521

Query: 203 DSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKH 262
           D G YV  A +A+          V  P +    DP   P  +++ L  A  T  V  G  
Sbjct: 522 DEGDYV-FAPDAYN---------VTLPAKVHVIDP---PKIILDGLD-ADNTVTVIAGNK 567

Query: 263 AKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
            +    + G+P P+  W    + ++    R+          L +   +  D G+Y    +
Sbjct: 568 LRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLK 627

Query: 323 NSAGQTLSAVQLHV 336
           N AG+  +++++ V
Sbjct: 628 NEAGEAHASIKVKV 641



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 1/78 (1%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G +A   C V G P+P+I W      ++ D R  M+ ++ G   L++      D G Y C
Sbjct: 1068 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQ-GVCTLEIRKPSPYDGGTYCC 1126

Query: 320  AARNSAGQTLSAVQLHVK 337
             A N  G      +L VK
Sbjct: 1127 KAVNDLGTVEIECKLEVK 1144



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 20/68 (29%), Positives = 28/68 (41%)

Query: 24   VSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYV 83
            ++G  A L C V G P P + W K    +    R    ++     L +    P D G Y 
Sbjct: 1066 IAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYC 1125

Query: 84   CRARNAAG 91
            C+A N  G
Sbjct: 1126 CKAVNDLG 1133



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 68/342 (19%), Positives = 125/342 (36%), Gaps = 48/342 (14%)

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQT 1277
            GL   A+   RV  + AAG +    Y+         P L    ++ EPP   +     QT
Sbjct: 806  GLPTDAKIFVRVKAVNAAGASEPKYYS--------QPIL--VKEIIEPPKIRIPRHLKQT 855

Query: 1278 RVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDA 1336
             +R   G  + LV+   G   P + W KDG  +  + ++ +  +    ++ ++ A    +
Sbjct: 856  YIRRV-GEAVNLVIPFQGKPRPELTWKKDGAEI-DKNQINIRNSETDTIIFIRKAERSHS 913

Query: 1337 GEYLCDAPQDSRIFLVSVE--------EPLLVKLVS---ELTPLT----VHEGDDATFRC 1381
            G+Y      D  +   S++         P +VK+     E   LT      +G+ A    
Sbjct: 914  GKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGY 973

Query: 1382 EVSPPDA-DVTWL-------RNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA 1433
             +   D   + W        R  A +T   ++ +      R+ +   C L +  T+T  +
Sbjct: 974  TIQKADKKSMEWFTVIEHYHRTSATIT---ELVIGNEYYFRVFSENMCGLSEDATMTKES 1030

Query: 1434 GSTATSARLHVRET--------ELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVR 1485
               A   +++              +F + L +  A  G +  L     R      + W++
Sbjct: 1031 AVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSV-RGNPKPKITWMK 1089

Query: 1486 GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD 1527
                +  D R  M  +  +  L I      D GTY C++ +D
Sbjct: 1090 NKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1131



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 1643 GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
            G  AT  C +       +TW K+  A+   PR R+ +      L++R+  P D GTY C
Sbjct: 1068 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCC 1126



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 15/47 (31%), Positives = 23/47 (48%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQD 1885
            + W++    +    +Y M S+    +L I    P D GTYCC+A  D
Sbjct: 1085 ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1131



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 5/77 (6%)

Query: 1374 GDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
            G +AT  C V   P   +TW++N   +   P+  M  N     L +R     D GT   +
Sbjct: 1068 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCK 1127

Query: 1433 A----GSTATSARLHVR 1445
            A    G+     +L V+
Sbjct: 1128 AVNDLGTVEIECKLEVK 1144



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 4/72 (5%)

Query: 34  VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEA 93
           V L +P   V W K GQ++  S +  F   G +  L +     TD   Y       AG+ 
Sbjct: 299 VELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV----TAGDE 354

Query: 94  YAAAAVTVLEPP 105
             +  + V EPP
Sbjct: 355 KCSTELFVREPP 366



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/55 (30%), Positives = 23/55 (41%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            V W + G E+ P  KY     G    L I++ +  D   Y   AG +   T L V
Sbjct: 308  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFV 362


>gi|45976288 myosin binding protein C, slow type isoform 1 [Homo
            sapiens]
          Length = 1171

 Score =  116 bits (291), Expect = 2e-25
 Identities = 130/532 (24%), Positives = 212/532 (39%), Gaps = 37/532 (6%)

Query: 1207 SHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
            S  G+ +Q  E  E H+      + I  A    AG Y C+        S SF ++V E  
Sbjct: 129  SKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHES- 187

Query: 1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVL 1326
                          +TP  D+      SG G       D   L  +  V+ +Q    QV 
Sbjct: 188  ------------TGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVK-QQEEEPQVD 234

Query: 1327 RVQGARSGDAGEYLCDAPQDS---------RIFLVSVEEPLLVKLVSELTPL-TVHEGDD 1376
              +  ++    EY   A Q           R+  +  EE         L P   V +G  
Sbjct: 235  VWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGR 294

Query: 1377 ATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGST 1436
              F  E++ P  +V W +NG  + P  +      G  RIL +  CQ+ D     + AG  
Sbjct: 295  VRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDE 354

Query: 1437 ATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPL--PHDS 1494
              S  L VRE  ++  ++L+D  A  G+ V LE E     A   V+W + G+ +     S
Sbjct: 355  KCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDA--NVKWFKNGEEIIPGPKS 412

Query: 1495 RLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEG 1554
            R  +  +G  H L I G   AD   Y   +   ++ A+LSV  + L++L PL D T++ G
Sbjct: 413  RYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLG 472

Query: 1555 GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTAD 1614
                 + E+S E + G+W + G+ +    +  +   G  H+LV+      D G   F  D
Sbjct: 473  KEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPD 531

Query: 1615 --SLRCAARLIVREVPVTIVRG---PHDLEVTEGDTATFECELS-QALADVTWEKDGNAL 1668
              ++   A++ V + P  I+ G    + + V  G+    E  +S +      W +   A+
Sbjct: 532  AYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAI 591

Query: 1669 TP-SPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTV 1719
               S R+R ++      L +      D+G Y   +    AG    +++ + V
Sbjct: 592  MEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKN-EAGEAHASIKVKVV 642



 Score =  116 bits (291), Expect = 2e-25
 Identities = 96/368 (26%), Positives = 159/368 (43%), Gaps = 12/368 (3%)

Query: 915  RVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974
            RV    EL  P  EV+W K+G+E+  S   + + +   R L +   Q+ D  EY     D
Sbjct: 294  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 353

Query: 975  ESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEV--EES 1032
            E  S  + V EPP+ +    ++ T  A   E V L CE+S +DA V+W+K+G E+     
Sbjct: 354  EKCSTELFVREPPIMVTKQLEDTT--AYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 411

Query: 1033 EALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLH 1092
                +  +G +  L++  A   D  E+        +   ++V   P +I+ P     D  
Sbjct: 412  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLT---DQT 468

Query: 1093 FGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYV 1152
                  + L+CE++      +W K+GL V+ SD L++  +G    L + +A  ED G+YV
Sbjct: 469  VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYV 527

Query: 1153 C--ETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHN 1209
               +  +  +   V + +PP   L      + + V  G  + L   +S    P  +WS  
Sbjct: 528  FAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 587

Query: 1210 GRPVQEGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVR 1268
             + + EG G +   +      L I  A    +G+Y        G    S  V+V + P  
Sbjct: 588  DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 647

Query: 1269 VVAPEAAQ 1276
             VAP   +
Sbjct: 648  PVAPTVTE 655



 Score =  113 bits (283), Expect = 2e-24
 Identities = 83/342 (24%), Positives = 146/342 (42%), Gaps = 22/342 (6%)

Query: 1551 ISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVS 1610
            + +GG   F +EL+   +  +W + G ++ P  K      G +  L +N   + D     
Sbjct: 289  VDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYY 348

Query: 1611 FTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELSQALADVTWEKDGNALTP 1670
             TA   +C+  L VRE P+ + +   D     G+    ECE+S+  A+V W K+G  + P
Sbjct: 349  VTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIP 408

Query: 1671 SP--RLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERTVAVLSELRSV 1728
             P  R R++  G + +L +     +DA  YS  + T      +L+V  + + +L+ L   
Sbjct: 409  GPKSRYRIRVEGKKHILIIEGATKADAAEYS-VMTTGGQSSAKLSVDLKPLKILTPLTDQ 467

Query: 1729 SAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEV 1788
            +   G     +C +SE    G+W   G P++   R+++  +G+ H LV++    ED G+ 
Sbjct: 468  TVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 526

Query: 1789 RFQAGPAQSLALLEVEALPLQMCRHPPR----------EKTVLVGRRAVLEVTVS-RSGG 1837
             F           +V  +       PP+            TV+ G +  LE+ +S     
Sbjct: 527  VFAPDAYNVTLPAKVHVI------DPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 580

Query: 1838 HVCWLREGAELCPGD-KYEMRSHGPTHSLVIHDVRPEDQGTY 1878
               W R    +  G  +    S+  + +LVI     +D G Y
Sbjct: 581  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVY 622



 Score =  112 bits (280), Expect = 3e-24
 Identities = 75/243 (30%), Positives = 115/243 (47%), Gaps = 7/243 (2%)

Query: 1639 EVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            +V +G    F  EL+    +V W K+G  + PS +   +  G +R+L +  C  +D   Y
Sbjct: 288  QVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 347

Query: 1699 SCAVGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPL 1758
                G  +     L VRE  + V  +L   +A  G+    EC VSE +   +W   G  +
Sbjct: 348  YVTAGDEKCS-TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI 406

Query: 1759 RPG--ARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPR 1816
             PG  +R RIR EGKKHIL++      DA E        QS A L V+  PL++   P  
Sbjct: 407  IPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILT-PLT 465

Query: 1817 EKTVLVGRRAVLEVTVSRS-GGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQ 1875
            ++TV +G+   L+  +S +  G   W + G  +   D+ ++   G  H LVI +   ED+
Sbjct: 466  DQTVNLGKEICLKCEISENIPGK--WTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDE 523

Query: 1876 GTY 1878
            G Y
Sbjct: 524  GDY 526



 Score =  108 bits (270), Expect = 5e-23
 Identities = 92/328 (28%), Positives = 155/328 (47%), Gaps = 11/328 (3%)

Query: 838  VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSS 897
            V+WYK+GQE+  S   + E++G  R L +   Q +D  E+   AGDE     + + +   
Sbjct: 308  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPP- 366

Query: 898  WIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESP--ALLLQKEDTVRRL 955
             I+         A   ERV L CE+    A V+W K+GEE++  P     ++ E     L
Sbjct: 367  -IMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHIL 425

Query: 956  VLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSR 1015
            ++      D+ EY        +S  ++V   P++I+ P  + T+      C  L CE+S 
Sbjct: 426  IIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEIC--LKCEIS- 482

Query: 1016 EDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC--DAGDDSAFFTVT 1073
            E+ P +W K+GL V+ES+ L +   G   +LV+  A  ED G++V   DA + +    V 
Sbjct: 483  ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVH 542

Query: 1074 VTAPPERIVH--PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGA 1131
            V  PP+ I+    A  ++ +  G   R+E+     P    +    D   +E S  ++  +
Sbjct: 543  VIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTES 602

Query: 1132 EGPTRTLTLPHAQPEDAGEYVCETRHEA 1159
               + TL +  A+ +D+G Y    ++EA
Sbjct: 603  YPDSSTLVIDIAERDDSGVYHINLKNEA 630



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 86/365 (23%), Positives = 149/365 (40%), Gaps = 20/365 (5%)

Query: 733  RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            RV    EL+       WYK+GQ++  S   + +  G +  L +   ++ D  E+      
Sbjct: 294  RVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGD 353

Query: 793  VSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEV--EES 850
                  + V++PP+ +    E     A   E V L CEV  +DA V+W+K+G+E+     
Sbjct: 354  EKCSTELFVREPPIMVTKQLED--TTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPK 411

Query: 851  DFVVLENEGPHRRLVLPATQPSDGGEFQCV--AGDECAYFTVTITDVSSWIVYPSGKVYV 908
                +  EG    L++     +D  E+  +   G   A  +V +  +          V +
Sbjct: 412  SRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNL 471

Query: 909  AAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
                 + + L CE+       +WTK+G  V ES  L +  +  + +LV+     ED G+Y
Sbjct: 472  G----KEICLKCEISEN-IPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY 526

Query: 969  LCEIDDESASF--TVTVTEPPVRIIYPRD-EVTLIAVTLECVVLMCELSREDAP-VRWYK 1024
            +   D  + +    V V +PP  I+   D + T+  +    + L   +S E  P   W +
Sbjct: 527  VFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSR 586

Query: 1025 DGLEVEESEALVLERDGP-RCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPE 1079
                + E    +     P    LV+  A+ +D G +      +AG+  A   V V   P+
Sbjct: 587  GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPD 646

Query: 1080 RIVHP 1084
              V P
Sbjct: 647  PPVAP 651



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 85/358 (23%), Positives = 145/358 (40%), Gaps = 21/358 (5%)

Query: 1097 GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR 1156
            GRV    E+A    +V+WYK+G E+  S       +G  R L + + Q  D  EY     
Sbjct: 293  GRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAG 352

Query: 1157 HEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEG 1216
             E  +  + + EPP+         +  C   GE V L CE+S   A V W  NG  +  G
Sbjct: 353  DEKCSTELFVREPPIMVTKQLEDTTAYC---GERVELECEVSEDDANVKWFKNGEEIIPG 409

Query: 1217 --EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEA 1274
                  +  EG + +L I+ A  A A  Y+  +     +  LS  ++    P++++ P  
Sbjct: 410  PKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLK----PLKILTPLT 465

Query: 1275 AQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSG 1334
             QT      G ++ L   +S    P +W K+G  +    R+++   G    L +  A + 
Sbjct: 466  DQT---VNLGKEICLKCEIS-ENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTE 521

Query: 1335 DAGEYLCDAPQDSRIFL---VSVEEP--LLVKLVSELTPLTVHEGDDATFRCEVS-PPDA 1388
            D G+Y+  AP    + L   V V +P  +++  +     +TV  G+       +S  P  
Sbjct: 522  DEGDYVF-APDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPP 580

Query: 1389 DVTWLRNGAVVTPGP-QVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVR 1445
               W R    +  G  ++       S  L +   +  D+G   +   + A  A   ++
Sbjct: 581  KAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIK 638



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 80/305 (26%), Positives = 126/305 (41%), Gaps = 32/305 (10%)

Query: 614 PTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT-WFLNGEELKSNEPEGQVEPGALRYRI 672
           P   +   LED   Y GE      ++S       WF NGEE+        +     RYRI
Sbjct: 365 PPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEI--------IPGPKSRYRI 416

Query: 673 EQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSE 732
             +G +H LI+      D+ A       G Q SA L++   P+ IL+P      T    +
Sbjct: 417 RVEGKKHILIIEGATKADA-AEYSVMTTGGQSSAKLSVDLKPLKILTPL--TDQTVNLGK 473

Query: 733 RVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG 792
            + L CE+S  + P  W K+G  V+ES+ L V   GR H+L++  A  +D G++    + 
Sbjct: 474 EICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA 532

Query: 793 VSAFFGVTVQDPPVHIVDPREHVF--------VHAITSECVMLACEVDREDAPVRWYKDG 844
               + VT+    VH++DP + +         V  I    + L   +  E  P   +  G
Sbjct: 533 ----YNVTL-PAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRG 587

Query: 845 QE--VEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYFTVTITDVSSW 898
            +  +E S  +  E+      LV+   +  D G +       AG+  A   V + D    
Sbjct: 588 DKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDP 647

Query: 899 IVYPS 903
            V P+
Sbjct: 648 PVAPT 652



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 63/257 (24%), Positives = 108/257 (42%), Gaps = 15/257 (5%)

Query: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLY 308
           K     + V++G   +F    +  P+ E++W+  G+ + P  + + +  +    +L +  
Sbjct: 281 KILDPAYQVDKGGRVRF-VVELADPKLEVKWYKNGQEIRPSTKYI-FEHKGCQRILFINN 338

Query: 309 CQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSR 368
           CQ  D   Y      +AG    + +L V+EP +  T+ L+D          LEC+V    
Sbjct: 339 CQMTDDSEYYV----TAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 394

Query: 369 IPTAWFREDQRLLPCRK--YEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426
               WF+  + ++P  K  Y    EG    LII      D   Y     G  ++ A ++V
Sbjct: 395 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGG-QSSAKLSV 453

Query: 427 KGPILKRLPRKLD--VLEGENAVLLVETLEAGVEGRWSRDG---EELPVICQSSSGHMHA 481
               LK L    D  V  G+   L  E  E  + G+W+++G   +E   +     G +H 
Sbjct: 454 DLKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHK 512

Query: 482 LVLPGVTREDAGEVTFS 498
           LV+     ED G+  F+
Sbjct: 513 LVIANALTEDEGDYVFA 529



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 71/325 (21%), Positives = 131/325 (40%), Gaps = 31/325 (9%)

Query: 260 GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGG--FVLKVLYCQAKDRGLY 317
           G+  +  C V  + +  ++W   G  ++P  +   YR R  G   +L +      D   Y
Sbjct: 381 GERVELECEV-SEDDANVKWFKNGEEIIPGPKS-RYRIRVEGKKHILIIEGATKADAAEY 438

Query: 318 VCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIPTAWFRED 377
             +   + GQ  S+ +L V    L+   PL D          L+C++ +  IP  W +  
Sbjct: 439 --SVMTTGGQ--SSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEI-SENIPGKWTKNG 493

Query: 378 QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRK 437
             +    + + + +G + +L+I     +D+G Y+           NVT+   +    P K
Sbjct: 494 LPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVF-----APDAYNVTLPAKVHVIDPPK 548

Query: 438 --LDVLEGENAVLLVE----TLEAGVEGR------WSRDGEELPV----ICQSSSGHMHA 481
             LD L+ +N V ++      LE  + G       WSR  + +      I   S      
Sbjct: 549 IILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSST 608

Query: 482 LVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPP 541
           LV+    R+D+G    +L N        +K      P PP+   + +   +  ++ W+PP
Sbjct: 609 LVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPP 668

Query: 542 EPAPETPFI-YRLERQEVGSEDWIQ 565
                +P + Y +ER++  S  W++
Sbjct: 669 AYDGGSPILGYFIERKKKQSSRWMR 693



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 21  VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQ-LAASERLSFPADGAEHGLLLTAALPTDA 79
           V V++G +  L+  + GEPPP  +W +G +  +  S R+   +      L++  A   D+
Sbjct: 560 VTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDS 619

Query: 80  GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQP 113
           GVY    +N AGEA+A+  V V++ P  DP + P
Sbjct: 620 GVYHINLKNEAGEAHASIKVKVVDFP--DPPVAP 651



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 36/155 (23%), Positives = 64/155 (41%), Gaps = 8/155 (5%)

Query: 363 KVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVA 422
           ++ + ++   W++  Q + P  KY    +G  R L I+  +  DD  Y     G  +   
Sbjct: 300 ELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV-TAGDEKCST 358

Query: 423 NVTVKGPILKRLPRKLDVLE--GENAVLLVETLEAGVEGRWSRDGEELPVICQSS----- 475
            + V+ P +    +  D     GE   L  E  E     +W ++GEE+    +S      
Sbjct: 359 ELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRV 418

Query: 476 SGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRV 510
            G  H L++ G T+ DA E +      +++  L V
Sbjct: 419 EGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSV 453



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 70/314 (22%), Positives = 114/314 (36%), Gaps = 56/314 (17%)

Query: 26  GAEAELKCVVLGEPPPVVVWEKGGQQL--AASERLSFPADGAEHGLLLTAALPTDAGVYV 83
           G   EL+C V  E    V W K G+++      R     +G +H L++  A   DA  Y 
Sbjct: 381 GERVELECEV-SEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEY- 438

Query: 84  CRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGA 143
                  G++ A  +V          +L+P +               LT    Q V  G 
Sbjct: 439 -SVMTTGGQSSAKLSV----------DLKPLK--------------ILTPLTDQTVNLGK 473

Query: 144 EVVLTCRAG-GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLP 202
           E+ L C     +P     W K+G+ + E        +  GR          L I  A   
Sbjct: 474 EICLKCEISENIPGK---WTKNGLPVQE--SDRLKVVHKGRIHK-------LVIANALTE 521

Query: 203 DSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKH 262
           D G YV  A +A+          V  P +    DP   P  +++ L  A  T  V  G  
Sbjct: 522 DEGDYV-FAPDAYN---------VTLPAKVHVIDP---PKIILDGLD-ADNTVTVIAGNK 567

Query: 263 AKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAAR 322
            +    + G+P P+  W    + ++    R+          L +   +  D G+Y    +
Sbjct: 568 LRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLK 627

Query: 323 NSAGQTLSAVQLHV 336
           N AG+  +++++ V
Sbjct: 628 NEAGEAHASIKVKV 641



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 29/100 (29%), Positives = 43/100 (43%), Gaps = 3/100 (3%)

Query: 260  GKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVC 319
            G +A   C V G P+P+I W      ++ D R  M+ ++ G   L++      D G Y C
Sbjct: 1068 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQ-GVCTLEIRKPSPYDGGTYCC 1126

Query: 320  AARNSAGQTLSAVQLHVKEPRLRFTRPLQDV--EGREHGI 357
             A N  G      +L VK        P Q V  EG++  +
Sbjct: 1127 KAVNDLGTVEIECKLEVKVIYQGVNTPGQPVFLEGQQQSL 1166



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 30/112 (26%), Positives = 40/112 (35%), Gaps = 18/112 (16%)

Query: 24   VSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYV 83
            ++G  A L C V G P P + W K    +    R    ++     L +    P D G Y 
Sbjct: 1066 IAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYC 1125

Query: 84   CRARNAAG--EAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTG 133
            C+A N  G  E      V V+    + P                G PVFL G
Sbjct: 1126 CKAVNDLGTVEIECKLEVKVIYQGVNTP----------------GQPVFLEG 1161



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 68/342 (19%), Positives = 125/342 (36%), Gaps = 48/342 (14%)

Query: 1218 GLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQT 1277
            GL   A+   RV  + AAG +    Y+         P L    ++ EPP   +     QT
Sbjct: 806  GLPTDAKIFVRVKAVNAAGASEPKYYS--------QPIL--VKEIIEPPKIRIPRHLKQT 855

Query: 1278 RVRSTPGGDLELVVHLSGPGGP-VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDA 1336
             +R   G  + LV+   G   P + W KDG  +  + ++ +  +    ++ ++ A    +
Sbjct: 856  YIRRV-GEAVNLVIPFQGKPRPELTWKKDGAEI-DKNQINIRNSETDTIIFIRKAERSHS 913

Query: 1337 GEYLCDAPQDSRIFLVSVE--------EPLLVKLVS---ELTPLT----VHEGDDATFRC 1381
            G+Y      D  +   S++         P +VK+     E   LT      +G+ A    
Sbjct: 914  GKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGY 973

Query: 1382 EVSPPDA-DVTWL-------RNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA 1433
             +   D   + W        R  A +T   ++ +      R+ +   C L +  T+T  +
Sbjct: 974  TIQKADKKSMEWFTVIEHYHRTSATIT---ELVIGNEYYFRVFSENMCGLSEDATMTKES 1030

Query: 1434 GSTATSARLHVRET--------ELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVR 1485
               A   +++              +F + L +  A  G +  L     R      + W++
Sbjct: 1031 AVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSV-RGNPKPKITWMK 1089

Query: 1486 GGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHD 1527
                +  D R  M  +  +  L I      D GTY C++ +D
Sbjct: 1090 NKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1131



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 1643 GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC 1700
            G  AT  C +       +TW K+  A+   PR R+ +      L++R+  P D GTY C
Sbjct: 1068 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCC 1126



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 15/47 (31%), Positives = 23/47 (48%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQD 1885
            + W++    +    +Y M S+    +L I    P D GTYCC+A  D
Sbjct: 1085 ITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND 1131



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 5/77 (6%)

Query: 1374 GDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
            G +AT  C V   P   +TW++N   +   P+  M  N     L +R     D GT   +
Sbjct: 1068 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCK 1127

Query: 1433 A----GSTATSARLHVR 1445
            A    G+     +L V+
Sbjct: 1128 AVNDLGTVEIECKLEVK 1144



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 4/72 (5%)

Query: 34  VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCRARNAAGEA 93
           V L +P   V W K GQ++  S +  F   G +  L +     TD   Y       AG+ 
Sbjct: 299 VELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYV----TAGDE 354

Query: 94  YAAAAVTVLEPP 105
             +  + V EPP
Sbjct: 355 KCSTELFVREPP 366



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/55 (30%), Positives = 23/55 (41%)

Query: 1839 VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
            V W + G E+ P  KY     G    L I++ +  D   Y   AG +   T L V
Sbjct: 308  VKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFV 362


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  112 bits (281), Expect = 3e-24
 Identities = 149/592 (25%), Positives = 218/592 (36%), Gaps = 109/592 (18%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA------SERLSFPADG 64
           PP  +  P  + V  G  A L C   G P P + W KGG+++        S R+  P+ G
Sbjct: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS-G 86

Query: 65  AEHGLLLTAALPT--DAGVYVCRARNAAGEAY---AAAAVTVLEPPASDPELQPAERPLP 119
           +   L +     +  D GVYVC ARN  GEA    A+  V +L                 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------------- 132

Query: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCR-AGGLPEPTLYWEKDGMALDEVWDSSHFA 178
                     F   P    V  G   V+ C+   G PEPT+ W+KDG  LD+        
Sbjct: 133 ----------FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERIT 180

Query: 179 LQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPD 238
           ++ G+          L I   R  D+G YVC   N  G  ++          E       
Sbjct: 181 IRGGK----------LMITYTRKSDAGKYVCVGTNMVGERES----------EVAELTVL 220

Query: 239 EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDR 298
           E P+ V  P   A     V     A+F+C   G P P + W  +   L   R    Y  R
Sbjct: 221 ERPSFVKRPSNLA-----VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR----YEIR 271

Query: 299 DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIA 358
           D    LK+    A D G Y C A N  G+  ++  L V+EP     +P   V      + 
Sbjct: 272 D-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV- 329

Query: 359 VLECKVPNSRIPTAWFRED--QRLL----PCRKYEQIEEGTVRRLIIHRLKADDDGIYLC 412
             +C+   +  P  ++R +  Q LL    P +   +        L I  ++  D G Y+C
Sbjct: 330 TFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYIC 389

Query: 413 E---MRGRVRTVANVTVKGPILKRLP--------RKLDVLEGENAVLLVETLEAGVEGRW 461
           +   + G + T A + V   I  R P         +   ++G   +  V T        W
Sbjct: 390 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 449

Query: 462 SRDGEELPV----ICQSSSGHMHALVLPGVTREDAGEVT----FSLGNSRTTTLLRVK-- 511
            +DG  +      I Q  +G    L +      D G  T       G +  +  + V+  
Sbjct: 450 RKDGVLVSTQDSRIKQLENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF 506

Query: 512 CVKHSPPGP---------PILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLE 554
            V   PP P         P   E+    +NTV L+W+P   +  TP  Y +E
Sbjct: 507 GVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 558



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 128/538 (23%), Positives = 209/538 (38%), Gaps = 84/538 (15%)

Query: 726  LTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKV---- 780
            L  +  E   L C+      P   WYK G++VE       K D R HR++LP   +    
Sbjct: 38   LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD-----KDDPRSHRMLLPSGSLFFLR 92

Query: 781  --------QDSGEFECRTE---GVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLAC 829
                     D G + C      G +     +++   +     +    V     E  ++ C
Sbjct: 93   IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152

Query: 830  EVDR--EDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD---- 883
            +  R   +  + W KDG  +++ D  +    G   +L++  T+ SD G++ CV  +    
Sbjct: 153  QPPRGHPEPTISWKKDGSPLDDKDERITIRGG---KLMITYTRKSDAGKYVCVGTNMVGE 209

Query: 884  -ECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR-PWAEVRWTKDGEEVVES 941
             E     +T+ +  S++  PS    +A    +     CE    P   VRW KD  E+ +S
Sbjct: 210  RESEVAELTVLERPSFVKRPSN---LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266

Query: 942  PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD----ESASFTVTVTEPPVRIIYPRDEV 997
               +  ++D    L +  V   D G Y C  ++      AS T+TV EPP  ++ PRD+V
Sbjct: 267  RYEI--RDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 322

Query: 998  TLIAVTLECVVLMCELSREDAP-VRWYKDGLE--------VEESEALVLERDGPRCRLVL 1048
              +  T   V   CE +    P + W ++G +         + S    + + G    L +
Sbjct: 323  VALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD---LTI 376

Query: 1049 PAAQPEDGGEFVCD----AGD--DSAFFTVT--VTAPPERIVHPAARSLDLHFGAPGRVE 1100
               Q  D G ++C     AG     A+  VT  +   P  ++      ++      G   
Sbjct: 377  TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--PVNQTVAVDGTFV 434

Query: 1101 LRCEVAPAGSQV---RWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVC--ET 1155
            L C     GS V    W KDG+ V   D+     E     L + +A+  D G Y C   T
Sbjct: 435  LSC--VATGSPVPTILWRKDGVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIAST 490

Query: 1156 RHEAITFNVILAEP----PVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHN 1209
                 T++  +       PVQ     T P+ +  AP +P V   ++SR    + W  N
Sbjct: 491  PSGEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEV--TDVSRNTVTLSWQPN 545



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 128/521 (24%), Positives = 206/521 (39%), Gaps = 82/521 (15%)

Query: 802  QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGP 860
            +D P  IV+    + V     E   L C+ +    P + WYK G+ VE       +++  
Sbjct: 25   EDFPPRIVEHPSDLIVSK--GEPATLNCKAEGRPTPTIEWYKGGERVETD-----KDDPR 77

Query: 861  HRRLVLPA-------------TQPSDGGEFQCVAGDECAYFTVTITDVSSWIV------Y 901
              R++LP+             ++P D G + CVA +   Y    ++  +S  V      +
Sbjct: 78   SHRMLLPSGSLFFLRIVHGRKSRP-DEGVYVCVARN---YLGEAVSHNASLEVAILRDDF 133

Query: 902  PSGKVYVAAVRLERVVLTCELCR--PWAEVRWTKDGEEVVESPALLLQKEDTVR--RLVL 957
                  V     E  V+ C+  R  P   + W KDG     SP     +  T+R  +L++
Sbjct: 134  RQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG-----SPLDDKDERITIRGGKLMI 188

Query: 958  PAVQLEDSGEYLCEIDD-----ESASFTVTVTEPPVRIIYPRDEVTLIAVTLE-CVVLMC 1011
               +  D+G+Y+C   +     ES    +TV E P  +  P +    +AVT++      C
Sbjct: 189  TYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN----LAVTVDDSAEFKC 244

Query: 1012 ELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDD 1066
            E   +  P VRW KD  E+ +S   + +    + R V       D G + C A    G  
Sbjct: 245  EARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAG----DMGSYTCVAENMVGKA 300

Query: 1067 SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLE-----V 1121
             A  T+TV  PP  +V P  + + L      + E      PA   + W ++G +      
Sbjct: 301  EASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA---IFWRREGSQNLLFSY 357

Query: 1122 EASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITF---------NVILAEPPVQ 1172
            +   +    +   T  LT+ + Q  D G Y+C+T + A +          +VI   PP  
Sbjct: 358  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP- 416

Query: 1173 FLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLC 1231
               +   P    VA     VLSC  + +  P ++W  +G  V   +      E    VL 
Sbjct: 417  --VIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG--VLQ 472

Query: 1232 IQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
            I+ A     G YTC +    G  + S  ++V E  V V  P
Sbjct: 473  IRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 513



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 121/519 (23%), Positives = 187/519 (36%), Gaps = 99/519 (19%)

Query: 986  PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRC 1044
            PP  + +P D   LI    E   L C+      P + WYK G  VE       ++D PR 
Sbjct: 28   PPRIVEHPSD---LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET------DKDDPRS 78

Query: 1045 -RLVLPAAQ------------PEDGGEFVC-------DAGDDSAFFTVTVTAPPERIVHP 1084
             R++LP+                D G +VC       +A   +A   V +     R  +P
Sbjct: 79   HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR-QNP 137

Query: 1085 AARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQ 1144
            +   + +  G P  +E +         + W KDG  ++  D       G    L + + +
Sbjct: 138  S--DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK---LMITYTR 192

Query: 1145 PEDAGEYVCE------TRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELS 1198
              DAG+YVC        R   +    +L  P     +    PS L V   +     CE  
Sbjct: 193  KSDAGKYVCVGTNMVGERESEVAELTVLERP-----SFVKRPSNLAVTVDDSAEFKCEAR 247

Query: 1199 RAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLS 1257
                P V W  +   + +    E+  +     L I+       G YTC +    G    S
Sbjct: 248  GDPVPTVRWRKDDGELPKSR-YEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303

Query: 1258 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGER--------L 1309
             T+ V EPP  VV P      +  T     E       P   + W ++G +         
Sbjct: 304  ATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT---GNPQPAIFWRREGSQNLLFSYQPP 360

Query: 1310 ASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELT-- 1367
             S  R  + Q G   +  VQ     D G Y+C          ++V   ++ K   E+T  
Sbjct: 361  QSSSRFSVSQTGDLTITNVQ---RSDVGYYICQT--------LNVAGSIITKAYLEVTDV 409

Query: 1368 -----PLTVHEGD-------DATF--RC-EVSPPDADVTWLRNGAVV-TPGPQVEMAQNG 1411
                 P  + +G        D TF   C     P   + W ++G +V T   +++  +NG
Sbjct: 410  IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG 469

Query: 1412 SSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRE 1446
               +L +R  +LGD G  T  A    G    SA + V+E
Sbjct: 470  ---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 91/378 (24%), Positives = 145/378 (38%), Gaps = 44/378 (11%)

Query: 1355 EEPLLVKLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVT-----PGPQVEMA 1408
            +E    ++V   + L V +G+ AT  C+    P   + W + G  V      P     + 
Sbjct: 24   QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83

Query: 1409 QNGSSRILTLRGCQLG--DAGTVTLRAGSTATSARLHVRETELLFLR-----RLQDVRAE 1461
             +GS   L +   +    D G     A +    A  H    E+  LR        DV   
Sbjct: 84   PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143

Query: 1462 EGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYG 1521
             G+   +E +  R      + W + G PL         + G   +L I     +D G Y 
Sbjct: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG---KLMITYTRKSDAGKYV 200

Query: 1522 C-----ESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV-TGEWARG 1575
            C         +  +A L+V  R   V RP  ++ ++   SA F+ E   + V T  W + 
Sbjct: 201  CVGTNMVGERESEVAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259

Query: 1576 GVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSL----RCAARLIVREVPVTI 1631
              +L P  +  I  D   H L +  +   D G  +  A+++      +A L V+E P  +
Sbjct: 260  DGEL-PKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315

Query: 1632 VRGPHDLEVTEGDTATFECELS-QALADVTWEKDG--NAL------TPSPRLRLQALGTR 1682
            V+ P D  V  G T TF+CE +      + W ++G  N L        S R  +   G  
Sbjct: 316  VK-PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 374

Query: 1683 RLLQLRRCGPSDAGTYSC 1700
             +  ++R   SD G Y C
Sbjct: 375  TITNVQR---SDVGYYIC 389



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 114/461 (24%), Positives = 175/461 (37%), Gaps = 83/461 (18%)

Query: 1481 VRWVRGGQPL------PHDSRLSMAQDGHIHRLFIHG-VILADQGTYGCESHHDRTLARL 1533
            + W +GG+ +      P   R+ +          +HG     D+G Y C + +    A  
Sbjct: 60   IEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVS 119

Query: 1534 SVRPRQLRVLRP-----LEDVTISEGGSATFQLE--LSQEGVTGEWARGGVQLYPGPKCH 1586
                 ++ +LR        DV ++ G  A  + +        T  W + G  L       
Sbjct: 120  HNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL------- 172

Query: 1587 IHSDGHRHRLVLNGLGL-------ADSG---CV--SFTADSLRCAARLIVREVPVTIVRG 1634
               D    R+ + G  L       +D+G   CV  +   +     A L V E P + V+ 
Sbjct: 173  ---DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERP-SFVKR 228

Query: 1635 PHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPS 1693
            P +L VT  D+A F+CE     +  V W KD   L P  R  ++   T   L++R+    
Sbjct: 229  PSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDDHT---LKIRKVTAG 284

Query: 1694 DAGTYSCA----VGTARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTG 1749
            D G+Y+C     VG A A    LTV+E    V+     V A  G   TF+C     E TG
Sbjct: 285  DMGSYTCVAENMVGKAEAS-ATLTVQEPPHFVVKPRDQVVAL-GRTVTFQC-----EATG 337

Query: 1750 R------WELGG--------RPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ---- 1791
                   W   G        +P +  +R  + Q G    L ++ ++  D G    Q    
Sbjct: 338  NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD---LTITNVQRSDVGYYICQTLNV 394

Query: 1792 AGPAQSLALLEVEAL----PLQMCRHPPREKTVLVGRRAVLEVTVSRSG-GHVCWLREGA 1846
            AG   + A LEV  +    P  + R  P  +TV V    VL    + S    + W ++G 
Sbjct: 395  AGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV 454

Query: 1847 ELCPGD-KYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDS 1886
             +   D + +   +G    L I   +  D G Y C A   S
Sbjct: 455  LVSTQDSRIKQLENG---VLQIRYAKLGDTGRYTCIASTPS 492



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 58/237 (24%), Positives = 91/237 (38%), Gaps = 39/237 (16%)

Query: 669 RYRIEQKGLQHRLILHAVKHQDSGALVGFSCPG------VQDSAALTIQESPVHILSPQD 722
           RY I      H L +  V   D G+   ++C         + SA LT+QE P  ++ P+D
Sbjct: 267 RYEIRD---DHTLKIRKVTAGDMGS---YTCVAENMVGKAEASATLTVQEPPHFVVKPRD 320

Query: 723 RVSLTFTTSERVVLTCELSRVDFPAT-WYKDG--------QKVEESELLVVKMDGRKHRL 773
           +V         V   CE +    PA  W ++G        Q  + S    V   G    L
Sbjct: 321 QV---VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG---DL 374

Query: 774 ILPEAKVQDSGEFECRTEGVS------AFFGVT--VQDPPVHIVDPREHVFVHAITSECV 825
            +   +  D G + C+T  V+      A+  VT  + D P  ++         A+    V
Sbjct: 375 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 434

Query: 826 MLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA 881
            L+C       P + W KDG  V   D  + + E  +  L +   +  D G + C+A
Sbjct: 435 -LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIA 488


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  112 bits (281), Expect = 3e-24
 Identities = 149/592 (25%), Positives = 218/592 (36%), Gaps = 109/592 (18%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA------SERLSFPADG 64
           PP  +  P  + V  G  A L C   G P P + W KGG+++        S R+  P+ G
Sbjct: 67  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS-G 125

Query: 65  AEHGLLLTAALPT--DAGVYVCRARNAAGEAY---AAAAVTVLEPPASDPELQPAERPLP 119
           +   L +     +  D GVYVC ARN  GEA    A+  V +L                 
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------------- 171

Query: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCR-AGGLPEPTLYWEKDGMALDEVWDSSHFA 178
                     F   P    V  G   V+ C+   G PEPT+ W+KDG  LD+        
Sbjct: 172 ----------FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERIT 219

Query: 179 LQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPD 238
           ++ G+          L I   R  D+G YVC   N  G  ++          E       
Sbjct: 220 IRGGK----------LMITYTRKSDAGKYVCVGTNMVGERES----------EVAELTVL 259

Query: 239 EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDR 298
           E P+ V  P   A     V     A+F+C   G P P + W  +   L   R    Y  R
Sbjct: 260 ERPSFVKRPSNLA-----VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR----YEIR 310

Query: 299 DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIA 358
           D    LK+    A D G Y C A N  G+  ++  L V+EP     +P   V      + 
Sbjct: 311 D-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV- 368

Query: 359 VLECKVPNSRIPTAWFRED--QRLL----PCRKYEQIEEGTVRRLIIHRLKADDDGIYLC 412
             +C+   +  P  ++R +  Q LL    P +   +        L I  ++  D G Y+C
Sbjct: 369 TFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYIC 428

Query: 413 E---MRGRVRTVANVTVKGPILKRLP--------RKLDVLEGENAVLLVETLEAGVEGRW 461
           +   + G + T A + V   I  R P         +   ++G   +  V T        W
Sbjct: 429 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 488

Query: 462 SRDGEELPV----ICQSSSGHMHALVLPGVTREDAGEVT----FSLGNSRTTTLLRVK-- 511
            +DG  +      I Q  +G    L +      D G  T       G +  +  + V+  
Sbjct: 489 RKDGVLVSTQDSRIKQLENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF 545

Query: 512 CVKHSPPGP---------PILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLE 554
            V   PP P         P   E+    +NTV L+W+P   +  TP  Y +E
Sbjct: 546 GVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597



 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 128/538 (23%), Positives = 209/538 (38%), Gaps = 84/538 (15%)

Query: 726  LTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILPEAKV---- 780
            L  +  E   L C+      P   WYK G++VE       K D R HR++LP   +    
Sbjct: 77   LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD-----KDDPRSHRMLLPSGSLFFLR 131

Query: 781  --------QDSGEFECRTE---GVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLAC 829
                     D G + C      G +     +++   +     +    V     E  ++ C
Sbjct: 132  IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 191

Query: 830  EVDR--EDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD---- 883
            +  R   +  + W KDG  +++ D  +    G   +L++  T+ SD G++ CV  +    
Sbjct: 192  QPPRGHPEPTISWKKDGSPLDDKDERITIRGG---KLMITYTRKSDAGKYVCVGTNMVGE 248

Query: 884  -ECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCR-PWAEVRWTKDGEEVVES 941
             E     +T+ +  S++  PS    +A    +     CE    P   VRW KD  E+ +S
Sbjct: 249  RESEVAELTVLERPSFVKRPSN---LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305

Query: 942  PALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD----ESASFTVTVTEPPVRIIYPRDEV 997
               +  ++D    L +  V   D G Y C  ++      AS T+TV EPP  ++ PRD+V
Sbjct: 306  RYEI--RDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 361

Query: 998  TLIAVTLECVVLMCELSREDAP-VRWYKDGLE--------VEESEALVLERDGPRCRLVL 1048
              +  T   V   CE +    P + W ++G +         + S    + + G    L +
Sbjct: 362  VALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD---LTI 415

Query: 1049 PAAQPEDGGEFVCD----AGD--DSAFFTVT--VTAPPERIVHPAARSLDLHFGAPGRVE 1100
               Q  D G ++C     AG     A+  VT  +   P  ++      ++      G   
Sbjct: 416  TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--PVNQTVAVDGTFV 473

Query: 1101 LRCEVAPAGSQV---RWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVC--ET 1155
            L C     GS V    W KDG+ V   D+     E     L + +A+  D G Y C   T
Sbjct: 474  LSC--VATGSPVPTILWRKDGVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIAST 529

Query: 1156 RHEAITFNVILAEP----PVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHN 1209
                 T++  +       PVQ     T P+ +  AP +P V   ++SR    + W  N
Sbjct: 530  PSGEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEV--TDVSRNTVTLSWQPN 584



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 128/521 (24%), Positives = 206/521 (39%), Gaps = 82/521 (15%)

Query: 802  QDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGP 860
            +D P  IV+    + V     E   L C+ +    P + WYK G+ VE       +++  
Sbjct: 64   EDFPPRIVEHPSDLIVSK--GEPATLNCKAEGRPTPTIEWYKGGERVETD-----KDDPR 116

Query: 861  HRRLVLPA-------------TQPSDGGEFQCVAGDECAYFTVTITDVSSWIV------Y 901
              R++LP+             ++P D G + CVA +   Y    ++  +S  V      +
Sbjct: 117  SHRMLLPSGSLFFLRIVHGRKSRP-DEGVYVCVARN---YLGEAVSHNASLEVAILRDDF 172

Query: 902  PSGKVYVAAVRLERVVLTCELCR--PWAEVRWTKDGEEVVESPALLLQKEDTVR--RLVL 957
                  V     E  V+ C+  R  P   + W KDG     SP     +  T+R  +L++
Sbjct: 173  RQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG-----SPLDDKDERITIRGGKLMI 227

Query: 958  PAVQLEDSGEYLCEIDD-----ESASFTVTVTEPPVRIIYPRDEVTLIAVTLE-CVVLMC 1011
               +  D+G+Y+C   +     ES    +TV E P  +  P +    +AVT++      C
Sbjct: 228  TYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN----LAVTVDDSAEFKC 283

Query: 1012 ELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDD 1066
            E   +  P VRW KD  E+ +S   + +    + R V       D G + C A    G  
Sbjct: 284  EARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAG----DMGSYTCVAENMVGKA 339

Query: 1067 SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLE-----V 1121
             A  T+TV  PP  +V P  + + L      + E      PA   + W ++G +      
Sbjct: 340  EASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA---IFWRREGSQNLLFSY 396

Query: 1122 EASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITF---------NVILAEPPVQ 1172
            +   +    +   T  LT+ + Q  D G Y+C+T + A +          +VI   PP  
Sbjct: 397  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP- 455

Query: 1173 FLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLC 1231
               +   P    VA     VLSC  + +  P ++W  +G  V   +      E    VL 
Sbjct: 456  --VIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG--VLQ 511

Query: 1232 IQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAP 1272
            I+ A     G YTC +    G  + S  ++V E  V V  P
Sbjct: 512  IRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 552



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 125/536 (23%), Positives = 193/536 (36%), Gaps = 103/536 (19%)

Query: 973  DDESASFTVTVTE----PPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VRWYKDGL 1027
            DD S  +T +       PP  + +P D   LI    E   L C+      P + WYK G 
Sbjct: 50   DDNSLGYTGSRLRQEDFPPRIVEHPSD---LIVSKGEPATLNCKAEGRPTPTIEWYKGGE 106

Query: 1028 EVEESEALVLERDGPRC-RLVLPAAQ------------PEDGGEFVC-------DAGDDS 1067
             VE       ++D PR  R++LP+                D G +VC       +A   +
Sbjct: 107  RVET------DKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHN 160

Query: 1068 AFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDAL 1127
            A   V +     R  +P+   + +  G P  +E +         + W KDG  ++  D  
Sbjct: 161  ASLEVAILRDDFR-QNPS--DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER 217

Query: 1128 QLGAEGPTRTLTLPHAQPEDAGEYVCE------TRHEAITFNVILAEPPVQFLALETTPS 1181
                 G    L + + +  DAG+YVC        R   +    +L  P     +    PS
Sbjct: 218  ITIRGGK---LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERP-----SFVKRPS 269

Query: 1182 PLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHA 1240
             L V   +     CE      P V W  +   + +    E+  +     L I+       
Sbjct: 270  NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEIRDD---HTLKIRKVTAGDM 325

Query: 1241 GLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPV 1300
            G YTC +    G    S T+ V EPP  VV P      +  T     E       P   +
Sbjct: 326  GSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT---GNPQPAI 382

Query: 1301 RWYKDGER--------LASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLV 1352
             W ++G +          S  R  + Q G   +  VQ     D G Y+C          +
Sbjct: 383  FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ---RSDVGYYICQT--------L 431

Query: 1353 SVEEPLLVKLVSELT-------PLTVHEGD-------DATF--RC-EVSPPDADVTWLRN 1395
            +V   ++ K   E+T       P  + +G        D TF   C     P   + W ++
Sbjct: 432  NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 491

Query: 1396 GAVV-TPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRA----GSTATSARLHVRE 1446
            G +V T   +++  +NG   +L +R  +LGD G  T  A    G    SA + V+E
Sbjct: 492  GVLVSTQDSRIKQLENG---VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 544



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 122/505 (24%), Positives = 190/505 (37%), Gaps = 86/505 (17%)

Query: 1438 TSARLHVRETELLFLRRLQDVRAEEGQDVCLEVET-GRVGAAGAVRWVRGGQPL------ 1490
            T +RL   +     +    D+   +G+   L  +  GR      + W +GG+ +      
Sbjct: 57   TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGR--PTPTIEWYKGGERVETDKDD 114

Query: 1491 PHDSRLSMAQDGHIHRLFIHG-VILADQGTYGCESHHDRTLARLSVRPRQLRVLRP---- 1545
            P   R+ +          +HG     D+G Y C + +    A       ++ +LR     
Sbjct: 115  PRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ 174

Query: 1546 -LEDVTISEGGSATFQLE--LSQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLG 1602
               DV ++ G  A  + +        T  W + G  L          D    R+ + G  
Sbjct: 175  NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----------DDKDERITIRGGK 224

Query: 1603 L-------ADSG---CV--SFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFEC 1650
            L       +D+G   CV  +   +     A L V E P + V+ P +L VT  D+A F+C
Sbjct: 225  LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERP-SFVKRPSNLAVTVDDSAEFKC 283

Query: 1651 EL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCA----VGTA 1705
            E     +  V W KD   L P  R  ++   T   L++R+    D G+Y+C     VG A
Sbjct: 284  EARGDPVPTVRWRKDDGEL-PKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVGKA 339

Query: 1706 RAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGR------WELGG---- 1755
             A    LTV+E    V+     V A  G   TF+C     E TG       W   G    
Sbjct: 340  EAS-ATLTVQEPPHFVVKPRDQVVAL-GRTVTFQC-----EATGNPQPAIFWRREGSQNL 392

Query: 1756 ----RPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQ----AGPAQSLALLEVEAL- 1806
                +P +  +R  + Q G    L ++ ++  D G    Q    AG   + A LEV  + 
Sbjct: 393  LFSYQPPQSSSRFSVSQTGD---LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 449

Query: 1807 ---PLQMCRHPPREKTVLVGRRAVLEVTVSRSG-GHVCWLREGAELCPGD-KYEMRSHGP 1861
               P  + R  P  +TV V    VL    + S    + W ++G  +   D + +   +G 
Sbjct: 450  ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG- 508

Query: 1862 THSLVIHDVRPEDQGTYCCQAGQDS 1886
               L I   +  D G Y C A   S
Sbjct: 509  --VLQIRYAKLGDTGRYTCIASTPS 531



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 58/237 (24%), Positives = 91/237 (38%), Gaps = 39/237 (16%)

Query: 669 RYRIEQKGLQHRLILHAVKHQDSGALVGFSCPG------VQDSAALTIQESPVHILSPQD 722
           RY I      H L +  V   D G+   ++C         + SA LT+QE P  ++ P+D
Sbjct: 306 RYEIRD---DHTLKIRKVTAGDMGS---YTCVAENMVGKAEASATLTVQEPPHFVVKPRD 359

Query: 723 RVSLTFTTSERVVLTCELSRVDFPAT-WYKDG--------QKVEESELLVVKMDGRKHRL 773
           +V         V   CE +    PA  W ++G        Q  + S    V   G    L
Sbjct: 360 QV---VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG---DL 413

Query: 774 ILPEAKVQDSGEFECRTEGVS------AFFGVT--VQDPPVHIVDPREHVFVHAITSECV 825
            +   +  D G + C+T  V+      A+  VT  + D P  ++         A+    V
Sbjct: 414 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 473

Query: 826 MLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA 881
            L+C       P + W KDG  V   D  + + E  +  L +   +  D G + C+A
Sbjct: 474 -LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIA 527


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  111 bits (278), Expect = 6e-24
 Identities = 114/403 (28%), Positives = 156/403 (38%), Gaps = 64/403 (15%)

Query: 18  PRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE--RLSFPADGAEHGLLLTAAL 75
           P+ V V SG      C   G P P ++W      L   +  RL+   DG    L++    
Sbjct: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT---LMIRNTR 296

Query: 76  PTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGPR 135
            +D GVY C ARN+AGEA   +A+           L+ +  P          P F+  P+
Sbjct: 297 ESDQGVYQCMARNSAGEAKTQSAM-----------LRYSSLP--------AKPSFVIQPQ 337

Query: 136 SQWVLRGAEVVLTCRAGGLPEPTLYWEKD-GMALDEVWDSSHFALQPGRAEDGPGASLAL 194
              VL G    L C A G P P + W +D G+ LD    S H A   G         L L
Sbjct: 338 DTEVLIGTSTTLECMATGHPHPLITWTRDNGLELD---GSRHVATSSG---------LYL 385

Query: 195 RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKT 254
           + +  R  D G + CHA N+HG  QA A + V  PP+                    PK 
Sbjct: 386 QNITQR--DHGRFTCHANNSHGTVQAAANIIVQAPPQ----------------FTVTPKD 427

Query: 255 FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
             V E    ++ C   G P P I W   G  L  + +  +         L++      D+
Sbjct: 428 QVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVL----SSGTLRIDRAAQHDQ 483

Query: 315 GLYVCAARNSAGQTLSAVQLHVKEPRLR-FTRPLQDVEGREHGIAVLECKVPNSRIP-TA 372
           G Y C A +S G    +VQL VK   L  FT+  QD          + C       P   
Sbjct: 484 GQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIIT 543

Query: 373 WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR 415
           W +E  ++    K+   +EGT   L I+     D G Y C  R
Sbjct: 544 WNKEGVQITESGKFHVDDEGT---LTIYDAGFPDQGRYECVAR 583



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 87/326 (26%), Positives = 123/326 (37%), Gaps = 59/326 (18%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEK-GGQQLAASERLSFPADGAEHGLL 70
           P F+  P+   V+ G    L+C+  G P P++ W +  G +L  S  ++        GL 
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVA-----TSSGLY 384

Query: 71  LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
           L      D G + C A N+ G   AAA + V  PP                        F
Sbjct: 385 LQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ-----------------------F 421

Query: 131 LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
              P+ Q VL    V   C A G P P + W K G  L    +  H  L  G        
Sbjct: 422 TVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--EGQHTVLSSG-------- 471

Query: 191 SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKC 250
              LRI  A   D G Y C A ++ G  +    L V      P A         +     
Sbjct: 472 --TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-----KPKA---------LAVFTQ 515

Query: 251 APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
            P+   V  GK+    C+  G+P+P I W+ EG  +    +   + D +G   L +    
Sbjct: 516 LPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGK--FHVDDEG--TLTIYDAG 571

Query: 311 AKDRGLYVCAARNSAGQTLSAVQLHV 336
             D+G Y C ARNS G  ++ + L V
Sbjct: 572 FPDQGRYECVARNSFGLAVTNMFLTV 597



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 62/217 (28%), Positives = 91/217 (41%), Gaps = 36/217 (16%)

Query: 10  SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
           +PP F   P+   V+     E  C   G PPPV+VW K G QL    + +  + G    L
Sbjct: 417 APPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT---L 473

Query: 70  LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPV 129
            +  A   D G Y C+A ++ G    +  +TV +P A                      V
Sbjct: 474 RIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV-KPKA--------------------LAV 512

Query: 130 FLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPG 189
           F   P+   V  G  + ++C A G P+P + W K+G+   ++ +S  F +     ++G  
Sbjct: 513 FTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGV---QITESGKFHVD----DEG-- 563

Query: 190 ASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
               L I  A  PD G Y C ARN+ G A     L V
Sbjct: 564 ---TLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 77/319 (24%), Positives = 126/319 (39%), Gaps = 47/319 (14%)

Query: 1119 LEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRH---EAITFNVILAEPPVQFLA 1175
            L++E    L +  +G   TL + + +  D G Y C  R+   EA T + +L     ++ +
Sbjct: 274  LDLEDDTRLNVFDDG---TLMIRNTRESDQGVYQCMARNSAGEAKTQSAML-----RYSS 325

Query: 1176 LETTPSPLCVAPGEPVVL-----SCELSRAGAP---VVWSHNGRPVQEGEGLELHAEGPR 1227
            L   PS   + P +  VL     + E    G P   + W+ +        GLEL  +G R
Sbjct: 326  LPAKPS-FVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDN-------GLEL--DGSR 375

Query: 1228 RV-----LCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRST 1282
             V     L +Q       G +TC +  + G    +  + V  PP   V P+         
Sbjct: 376  HVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHA 435

Query: 1283 PGGDLELVVHLSGPGGPVR-WYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341
                +E +    G   PV  W K G +L  +G+  +  +G    LR+  A   D G+Y C
Sbjct: 436  ----VEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGT---LRIDRAAQHDQGQYEC 488

Query: 1342 DAPQDSRIFLVSVEEPLLVKLVSELTPL----TVHEGDDATFRCEV-SPPDADVTWLRNG 1396
             A     +  VSV+  +  K ++  T L    +V  G +    C     P   +TW + G
Sbjct: 489  QAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEG 548

Query: 1397 AVVTPGPQVEMAQNGSSRI 1415
              +T   +  +   G+  I
Sbjct: 549  VQITESGKFHVDDEGTLTI 567



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 83/376 (22%), Positives = 141/376 (37%), Gaps = 37/376 (9%)

Query: 817  VHAITSECVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            V   +   V   C  +    P + W  +   ++  D   L N      L++  T+ SD G
Sbjct: 243  VEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRL-NVFDDGTLMIRNTRESDQG 301

Query: 876  EFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVL----TCELC---RPWAE 928
             +QC+A +       T + +  +   P+   +V   +   V++    T E      P   
Sbjct: 302  VYQCMARNSAGE-AKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPL 360

Query: 929  VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDE----SASFTVTVT 984
            + WT+D    ++    +     T   L L  +   D G + C  ++      A+  + V 
Sbjct: 361  ITWTRDNGLELDGSRHVA----TSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQ 416

Query: 985  EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPV-RWYKDGLEVE-ESEALVLERDGP 1042
             PP   + P+D+V L    +E    +CE      PV  W K G ++  E +  VL     
Sbjct: 417  APPQFTVTPKDQVVLEEHAVE---WLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG-- 471

Query: 1043 RCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTV--TAPPERIVHPAARSLDLHFGAPGRVE 1100
               L +  A   D G++ C A        V+V  T  P+ +        D        + 
Sbjct: 472  --TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNIN 529

Query: 1101 LRCEVAPAGSQ-VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHE- 1158
            + C         + W K+G+++  S    +  EG   TLT+  A   D G Y C  R+  
Sbjct: 530  ISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG---TLTIYDAGFPDQGRYECVARNSF 586

Query: 1159 --AITFNVILAEPPVQ 1172
              A+T N+ L    +Q
Sbjct: 587  GLAVT-NMFLTVTAIQ 601



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 63/278 (22%), Positives = 102/278 (36%), Gaps = 38/278 (13%)

Query: 709 TIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMD 767
           ++   P  ++ PQD   L  T++    L C  +    P  TW +D           +++D
Sbjct: 325 SLPAKPSFVIQPQDTEVLIGTST---TLECMATGHPHPLITWTRDNG---------LELD 372

Query: 768 GRKH-----RLILPEAKVQDSGEFECRTEG----VSAFFGVTVQDPPVHIVDPREHVFVH 818
           G +H      L L     +D G F C        V A   + VQ PP   V P++ V   
Sbjct: 373 GSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQV--- 429

Query: 819 AITSECVMLACEVDREDAPVR-WYKDGQEVE-ESDFVVLENEGPHRRLVLPATQPSDGGE 876
            +    V   CE D    PV  W K G ++  E    VL +      L +      D G+
Sbjct: 430 VLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSG----TLRIDRAAQHDQGQ 485

Query: 877 FQCVAGDECAYFTVTI---TDVSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWT 932
           ++C A        V++       +  V+       +    + + ++C     P   + W 
Sbjct: 486 YECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWN 545

Query: 933 KDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLC 970
           K+G ++ ES    +  E T   L +      D G Y C
Sbjct: 546 KEGVQITESGKFHVDDEGT---LTIYDAGFPDQGRYEC 580



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 68/293 (23%), Positives = 107/293 (36%), Gaps = 45/293 (15%)

Query: 1610 SFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNAL 1668
            S T +   C +  I  E        P D+EV  G+T  F C        ++ W  + ++L
Sbjct: 223  SVTVEEFNCQSPRITFE--------PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSL 274

Query: 1669 TPSPRLRLQALGTRRLLQLRRCGPSDAGTYSC----AVGTAR--AGPVRLTVRERTVAVL 1722
                  RL       L+ +R    SD G Y C    + G A+  +  +R +      + +
Sbjct: 275  DLEDDTRLNVFDDGTLM-IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFV 333

Query: 1723 SELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVR-IRQEGKKHI-----LV 1776
             + +      G   T EC       TG       PL    R   +  +G +H+     L 
Sbjct: 334  IQPQDTEVLIGTSTTLECM-----ATGH----PHPLITWTRDNGLELDGSRHVATSSGLY 384

Query: 1777 LSELRAEDAGEVRFQA----GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV 1832
            L  +   D G     A    G  Q+ A + V+A P       P+++ VL      +E   
Sbjct: 385  LQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPP--QFTVTPKDQVVL--EEHAVEWLC 440

Query: 1833 SRSGGH---VCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
               G     + W + G +L    ++ + S G   +L I      DQG Y CQA
Sbjct: 441  EADGNPPPVIVWTKTGGQLPVEGQHTVLSSG---TLRIDRAAQHDQGQYECQA 490



 Score = 34.7 bits (78), Expect = 0.91
 Identities = 71/362 (19%), Positives = 131/362 (36%), Gaps = 38/362 (10%)

Query: 1361 KLVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVT--PGPQVEMAQNGSSRILT 1417
            ++  E   + V  G+   F C     P  ++ W+ N   +      ++ +  +G+   L 
Sbjct: 235  RITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGT---LM 291

Query: 1418 LRGCQLGDAGTVTLRAGSTATSARLH---VRETEL----LFLRRLQDVRAEEGQDVCLE- 1469
            +R  +  D G     A ++A  A+     +R + L     F+ + QD     G    LE 
Sbjct: 292  IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351

Query: 1470 VETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHR---LFIHGVILADQGTYGCESHH 1526
            + TG       + W R       D+ L +    H+     L++  +   D G + C +++
Sbjct: 352  MATGHPHPL--ITWTR-------DNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANN 402

Query: 1527 D----RTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPG 1582
                 +  A + V+      + P + V + E                  W + G QL   
Sbjct: 403  SHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462

Query: 1583 PKCHIHSDGHRH--RLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTI-VRGPHDLE 1639
             +  + S G     R   +  G  +   VS +    + + +L V+   + +  + P D  
Sbjct: 463  GQHTVLSSGTLRIDRAAQHDQGQYECQAVS-SLGVKKVSVQLTVKPKALAVFTQLPQDTS 521

Query: 1640 VTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            V  G      C    +    +TW K+G  +T S +  +   GT   L +   G  D G Y
Sbjct: 522  VEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGT---LTIYDAGFPDQGRY 578

Query: 1699 SC 1700
             C
Sbjct: 579  EC 580


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score =  110 bits (276), Expect = 1e-23
 Identities = 92/332 (27%), Positives = 138/332 (41%), Gaps = 29/332 (8%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
           P F    +   V+ G +  L+C V G P P + W   GQ +  + R +  A  AE  L +
Sbjct: 514 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYA-RSTCEAGVAE--LHI 570

Query: 72  TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
             ALP D G Y C A NA G+   +A VTV E  +S    + +E  LP   S   AP+FL
Sbjct: 571 QDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSS----RKSEYLLPVAPSKPTAPIFL 626

Query: 132 TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS 191
            G     V+ G++V +T +  G P P + W  +G  + E  D  HF        +  G  
Sbjct: 627 QGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHF--------EQRGTQ 677

Query: 192 LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP-LKC 250
            +L I      D+G Y C A N+ G  +  A+L V +P +              +P    
Sbjct: 678 HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDG------------TQPWFIS 725

Query: 251 APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
            P++   + G+     C + G P P + W  +G+ L  D         +  F L +   Q
Sbjct: 726 KPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQ 785

Query: 311 AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLR 342
               G Y    +N  G+    V L ++    R
Sbjct: 786 PWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 817



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 105/426 (24%), Positives = 156/426 (36%), Gaps = 58/426 (13%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE-RLSFPADGAEHGLL 70
           P F   P+   V      + +C V G P P V W   G  +   E  +    D   H L 
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473

Query: 71  LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
           L  A   D+G Y C A NA G+   +  + V                       E AP F
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVM-----------------EVAPSF 516

Query: 131 LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +  +   V+ G + VL C   G P P + W  +G  +      +    + G AE     
Sbjct: 517 SSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI----QYARSTCEAGVAE----- 567

Query: 191 SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP------PADPDEAPAPV 244
              L I  A   D G Y C A NA G     A + VH+   S       P  P +  AP+
Sbjct: 568 ---LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPI 624

Query: 245 ----VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
               +  LK       V +G        V G P PE+ W   G   + +     +  R  
Sbjct: 625 FLQGLSDLK-------VMDGSQVTMTVQVSGNPPPEVIWLHNGNE-IQESEDFHFEQRGT 676

Query: 301 GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP----RLRFTRPLQDVEGREHG 356
              L +     +D G Y C A NSAG+  +   L V+EP    +  F    + V      
Sbjct: 677 QHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQ 736

Query: 357 IAVLECKVPNSRIPTA-WFREDQRLLPCR---KYEQIEEGTVRRLIIHRLKADDDGIYLC 412
             ++ C +     PT  W R+ + L  C+    +E ++   V  L++ +++    G Y  
Sbjct: 737 SVLISCAIAGDPFPTVHWLRDGKAL--CKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEI 794

Query: 413 EMRGRV 418
            ++ RV
Sbjct: 795 LLKNRV 800



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 167/734 (22%), Positives = 269/734 (36%), Gaps = 109/734 (14%)

Query: 838  VRWYKDGQEVEESDFVVLEN--EGPHRRLVLPATQPSDGGEFQCVA--GDECAYFTVTIT 893
            V W+++GQ +      +L+    G    LV+ A    D G++ C A  G      TV +T
Sbjct: 64   VTWHRNGQPITSGGRFLLDCGIRGTFS-LVIHAVHEEDRGKYTCEATNGSGARQVTVELT 122

Query: 894  DVSSW--------IVYPSGKVYVA-----------------AVRLERVVL--------TC 920
               S+        +    G  + A                 A +L RVV+        +C
Sbjct: 123  VEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSC 182

Query: 921  ELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF 979
            ++  RP  +V W K    +  S  + + +++ ++ L +  V  +D G Y C + + S   
Sbjct: 183  KITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKA 242

Query: 980  TVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLER 1039
            +++        I   D      V  E      ++ +E   V   +  L+  E+ A     
Sbjct: 243  SMSAELS----IQGLDSANRSFVR-ETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNC 297

Query: 1040 DGPRCRLVLPAA---QPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAP 1096
              P+     P A   QP+   E   ++  DS       TAP   ++   + S+ L     
Sbjct: 298  SSPQRGGSPPWAANSQPQPPRESKLESCKDSPR-----TAPQTPVLQKTSSSITLQAA-- 350

Query: 1097 GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPE-DAGEYVCET 1155
                 R +  P          GL V +    +     P R  T P  QP   + + V + 
Sbjct: 351  -----RVQPEPRAP-------GLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKA 398

Query: 1156 RHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQ 1214
             +  I       +    F   E+ P    V   + V   CE+S    P V W   G PV+
Sbjct: 399  ANRRIPME---GQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVR 455

Query: 1215 EGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPE 1273
              EG +E++ +     LC+  A    +G Y+C +  A G  S S+T+QV    V  VAP 
Sbjct: 456  RQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPS 515

Query: 1274 AAQTRVRSTPGGDLELVVHLSGPGGPV---RWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
             +            + V+  S  G PV    W  +G+ +  Q      +AG  + L +Q 
Sbjct: 516  FSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI--QYARSTCEAGVAE-LHIQD 572

Query: 1331 ARSGDAGEYLC---------------------DAPQDSRIFLVSVEEPLLVKLVSELTPL 1369
            A   D G Y C                      + +   +  V+  +P     +  L+ L
Sbjct: 573  ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 632

Query: 1370 TVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGT 1428
             V +G   T   +VS  P  +V WL NG  +         Q G+   L ++     D GT
Sbjct: 633  KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGT 692

Query: 1429 VTLR----AGSTATSARLHVRE----TELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGA 1480
             T      AG   T A L V+E    T+  F+ + + V A  GQ V +            
Sbjct: 693  YTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAG-DPFPT 751

Query: 1481 VRWVRGGQPLPHDS 1494
            V W+R G+ L  D+
Sbjct: 752  VHWLRDGKALCKDT 765



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 112/424 (26%), Positives = 156/424 (36%), Gaps = 77/424 (18%)

Query: 105 PASDPELQP-----------AERPLPSPGSGEGA-PVFLTGPRSQWVLRGAEVVLTCRAG 152
           PA+ P  QP           A R +P  G  + A P F + P+SQ V     V   C   
Sbjct: 379 PATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVS 438

Query: 153 GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA-SLALRILAARLPDSGVYVCHA 211
           G+P+P + W  +G  +           Q G  E    A S  L +L AR  DSG Y C A
Sbjct: 439 GIPKPEVAWFLEGTPVRR---------QEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTA 489

Query: 212 RNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMG 271
            NA G       LQV +           A   V        K   V EG+    +C V G
Sbjct: 490 SNAQGQLSCSWTLQVER----------LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRG 539

Query: 272 KPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
            P P I W   G+P+   R         G   L +     +D G Y C A N+ GQ   +
Sbjct: 540 TPVPRITWLLNGQPIQYARSTC----EAGVAELHIQDALPEDHGTYTCLAENALGQVSCS 595

Query: 332 VQLHVKEPRLR------------------FTRPLQDVEGREHGIAVLECKVPNSRIP-TA 372
             + V E +                    F + L D++  +     +  +V  +  P   
Sbjct: 596 AWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVI 655

Query: 373 WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTVKGP 429
           W      +     +   + GT   L I  +  +D G Y CE     G VRT A +TV+ P
Sbjct: 656 WLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP 715

Query: 430 --------ILKRLPRKLDVLEGENAVLLVETLEAG---VEGRWSRDGEELPVICQSSSGH 478
                   I K  PR +    G++  +L+    AG       W RDG+ L   C+  +GH
Sbjct: 716 HDGTQPWFISK--PRSVTASLGQS--VLISCAIAGDPFPTVHWLRDGKAL---CK-DTGH 767

Query: 479 MHAL 482
              L
Sbjct: 768 FEVL 771



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/257 (28%), Positives = 109/257 (42%), Gaps = 33/257 (12%)

Query: 5    SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
            S  QG+ P F +  + V V  G +  L+C V  +PP  ++W   G+ L  ++ +    +G
Sbjct: 1091 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEG 1150

Query: 65   AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASD----PELQP------- 113
            +   + +  ALP D G+Y C A+N AG+A  +  VTV + PAS+    PE++        
Sbjct: 1151 SLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSL 1210

Query: 114  ------------AERPLP-SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLY 160
                         ++P P +P      P  +  P  Q V  G  V L  +  G    T  
Sbjct: 1211 PPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCT 1270

Query: 161  WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQA 220
            W K      ++ +S H  ++   +E+G      L ILAAR    G Y     N  G  QA
Sbjct: 1271 WMK---FRKQIQESEHMKVE--NSENGS----KLTILAARQEHCGCYTLLVENKLGSRQA 1321

Query: 221  GALLQVHQPPESPPADP 237
               L V   P+ P   P
Sbjct: 1322 QVNLTVVDKPDPPAGTP 1338



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 169/755 (22%), Positives = 266/755 (35%), Gaps = 164/755 (21%)

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
            D S   ++ +T  P  I+ P  R+L +  GA  + E R    P   QV W+++G  + + 
Sbjct: 20   DPSRVDSMPLTEAPAFILPP--RNLCIKEGATAKFEGRVRGYPE-PQVTWHRNGQPITSG 76

Query: 1125 DA--LQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVI------------LAEPP 1170
                L  G  G T +L +     ED G+Y CE  + +    V             L +P 
Sbjct: 77   GRFLLDCGIRG-TFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPV 135

Query: 1171 VQFL--------ALETTPS--------------PLCVAPGEPVVLSCELSRAGAP-VVWS 1207
            V           A+ET PS               + V  G+    SC+++    P V W 
Sbjct: 136  VSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWL 195

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC--QSGAAPGAPSLSFTVQ---- 1261
                P+Q    + +  +   +VL I        G+YTC   +G+   + S   ++Q    
Sbjct: 196  KGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDS 255

Query: 1262 ---------------VAEPPVRVVAPE--------AAQTRVRSTP--GGDLELVVHLSGP 1296
                           V +    V++ E        AA+++  S+P  GG      + S P
Sbjct: 256  ANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAAN-SQP 314

Query: 1297 GGP----VRWYKDGERLASQGRVQLEQAGA--RQVLRVQ--------GARSGDAGEYLCD 1342
              P    +   KD  R A Q  V  + + +   Q  RVQ        G  S    E    
Sbjct: 315  QPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRP 374

Query: 1343 AP----------------------QDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
            AP                       + RI +    +    K  S+     V E     FR
Sbjct: 375  APPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFR 434

Query: 1381 CEVSP-PDADVTWLRNGAVV-TPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGS--- 1435
            CEVS  P  +V W   G  V      +E+ ++  S  L L   +  D+GT +  A +   
Sbjct: 435  CEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQG 494

Query: 1436 ------TATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQP 1489
                  T    RL V E    F   L+D    EGQD  L+    R      + W+  GQP
Sbjct: 495  QLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSV-RGTPVPRITWLLNGQP 553

Query: 1490 LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESH--------------HDRTLARLS- 1534
            + +      A    +H   I   +  D GTY C +               H++  +R S 
Sbjct: 554  IQYARSTCEAGVAELH---IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSE 610

Query: 1535 -------VRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE-WARGGVQLYPGPKCH 1586
                    +P     L+ L D+ + +G   T  +++S        W   G ++      H
Sbjct: 611  YLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH 670

Query: 1587 IHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHD--------- 1637
                G +H L +  +   D+G  ++T ++   A    VR   V  V+ PHD         
Sbjct: 671  FEQRGTQHSLCIQEVFPEDTG--TYTCEAWNSAGE--VRTQAVLTVQEPHDGTQPWFISK 726

Query: 1638 ---LEVTEGDTATFECELS-QALADVTWEKDGNAL 1668
               +  + G +    C ++      V W +DG AL
Sbjct: 727  PRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKAL 761



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 64/229 (27%), Positives = 96/229 (41%), Gaps = 27/229 (11%)

Query: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
           AP F+  PR+  +  GA      R  G PEP + W ++G  +        F L     + 
Sbjct: 32  APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS---GGRFLL-----DC 83

Query: 187 GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL--------QVHQPPESPP-ADP 237
           G   + +L I A    D G Y C A N  G  Q    L        Q+ QP  S    D 
Sbjct: 84  GIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDR 143

Query: 238 DEAPAPVVEPL---KCAPK------TFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
             APA    P    +C PK         V EG+  +F C + G+P+P++ W     PL P
Sbjct: 144 FSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQP 203

Query: 289 DRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
              R+   +++G  VL++      D G+Y C   N +G+   + +L ++
Sbjct: 204 S-ARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 82/297 (27%), Positives = 114/297 (38%), Gaps = 40/297 (13%)

Query: 252 PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
           P++  V E +  KFRC V G P+PE+ W  EG P+      +   +  G   L +L  + 
Sbjct: 420 PQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKART 479

Query: 312 KDRGLYVCAARNSAGQ-----TLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
           +D G Y C A N+ GQ     TL   +L V E    F+  L+D    E    VL+C V  
Sbjct: 480 RDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRG 539

Query: 367 SRIP-TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVA 422
           + +P   W    Q   P +      E  V  L I     +D G Y C      G+V   A
Sbjct: 540 TPVPRITWLLNGQ---PIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSA 596

Query: 423 NVTV--------------------KGPILKRLPRKLDVLEGENAVLLVETL-EAGVEGRW 461
            VTV                      PI  +    L V++G    + V+       E  W
Sbjct: 597 WVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIW 656

Query: 462 SRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTF----SLGNSRTTTLLRVK 511
             +G E+           G  H+L +  V  ED G  T     S G  RT  +L V+
Sbjct: 657 LHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ 713



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 89/371 (23%), Positives = 146/371 (39%), Gaps = 43/371 (11%)

Query: 1005 ECVVLMCELSREDAP-VRWYKDGLEVEESEALV-LERDGPRCRLVLPAAQPEDGGEFVCD 1062
            + V   CE+S    P V W+ +G  V   E  + +  D     L L  A+  D G + C 
Sbjct: 429  QTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCT 488

Query: 1063 AGDDSAFFTVTVTAPPERI----VHPAARSL--DLHFGAPGRVELRCEVAPAG-SQVRWY 1115
            A +     + + T   ER+    V P+  S+  D          L+C V      ++ W 
Sbjct: 489  ASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWL 548

Query: 1116 KDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA--------ITFNVILA 1167
             +G  ++ + +     E     L +  A PED G Y C   +          +T +   +
Sbjct: 549  LNGQPIQYARST---CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKS 605

Query: 1168 EPPVQFL-----ALETTP------SPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQE 1215
                ++L     +  T P      S L V  G  V ++ ++S    P V+W HNG  +QE
Sbjct: 606  SRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQE 665

Query: 1216 GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEP-----PVRVV 1270
             E       G +  LCIQ   P   G YTC++  + G       + V EP     P  + 
Sbjct: 666  SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFIS 725

Query: 1271 APEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQ-GRVQLEQAGARQVLRV 1328
             P +    V ++ G  + +   ++G P   V W +DG+ L    G  ++ Q      L +
Sbjct: 726  KPRS----VTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVL 781

Query: 1329 QGARSGDAGEY 1339
            +  +   AG+Y
Sbjct: 782  KKVQPWHAGQY 792



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 57/232 (24%), Positives = 88/232 (37%), Gaps = 37/232 (15%)

Query: 234 PADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRL 293
           P+  D  P          P+   + EG  AKF   V G PEP++ WH  G+P+    R L
Sbjct: 21  PSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFL 80

Query: 294 MYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK---------------- 337
           +     G F L +     +DRG Y C A N +G     V+L V+                
Sbjct: 81  LDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTL 140

Query: 338 -----------------EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQR 379
                            E   +F   L  V  +E  +    CK+     P   W + +  
Sbjct: 141 GDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVP 200

Query: 380 LLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM---RGRVRTVANVTVKG 428
           L P  +    E+  ++ L IH +  DD G+Y C +    G+    A ++++G
Sbjct: 201 LQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG 252



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 70/298 (23%), Positives = 107/298 (35%), Gaps = 54/298 (18%)

Query: 1635 PHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPR----LRLQALGTRRLLQLRR 1689
            P   EV E  T  F CE+S     +V W  +G   TP  R    + +        L L +
Sbjct: 420  PQSQEVKENQTVKFRCEVSGIPKPEVAWFLEG---TPVRRQEGSIEVYEDAGSHYLCLLK 476

Query: 1690 CGPSDAGTYSCAVGTARAG--------PVRLTVRERTVAVLSELRSVSAREGDGATFECT 1741
                D+GTYSC    A+            RL V E   +  S L+  +  EG     +C+
Sbjct: 477  ARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCS 536

Query: 1742 VSEVETTG-RWELGGRPLRPGARVRIRQEGKKHI-------------------------- 1774
            V         W L G+P++           + HI                          
Sbjct: 537  VRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSA 596

Query: 1775 -LVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS 1833
             + + E ++    E      P++  A + ++ L          +  V+ G +  + V VS
Sbjct: 597  WVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS---------DLKVMDGSQVTMTVQVS 647

Query: 1834 RSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTR 1890
             +    V WL  G E+   + +     G  HSL I +V PED GTY C+A   +   R
Sbjct: 648  GNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVR 705



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 63/232 (27%), Positives = 83/232 (35%), Gaps = 31/232 (13%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG--- 68
           P F+  PR + +  GA A+ +  V G P P V W + GQ + +  R  F  D    G   
Sbjct: 33  PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGR--FLLDCGIRGTFS 90

Query: 69  LLLTAALPTDAGVYVCRARNAAGEAYAAAAVT------------VLEPPASDPELQPAER 116
           L++ A    D G Y C A N +G       +T            V+     D    PA  
Sbjct: 91  LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVE 150

Query: 117 PLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSH 176
             PS   GE  P F T      V  G     +C+  G P+P + W K            +
Sbjct: 151 TRPSIW-GECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLK-----------GN 198

Query: 177 FALQPGR--AEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
             LQP    +         L I      D GVY C   N  G A   A L +
Sbjct: 199 VPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 90/387 (23%), Positives = 150/387 (38%), Gaps = 62/387 (16%)

Query: 626 QVYDGEDAVFSLDLSTIIQG--TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLIL 683
           +V + +   F  ++S I +    WFL G  ++  E  G +E       + +    H L L
Sbjct: 424 EVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQE--GSIE-------VYEDAGSHYLCL 474

Query: 684 HAVKHQDSGALVGFSCPGV----QDSAALTIQESPVHILSPQDRVSLTFTT-----SERV 734
              + +DSG    +SC       Q S + T+Q   + ++      S           +  
Sbjct: 475 LKARTRDSGT---YSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDF 531

Query: 735 VLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG- 792
           VL C +     P  TW  +GQ ++ +           H   + +A  +D G + C  E  
Sbjct: 532 VLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH---IQDALPEDHGTYTCLAENA 588

Query: 793 ---VSAFFGVTVQDP----------PVHIVDPREHVFVHAITSECVM------LACEVDR 833
              VS    VTV +           PV    P   +F+  ++   VM      +  +V  
Sbjct: 589 LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSG 648

Query: 834 EDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYF 888
              P V W  +G E++ES+    E  G    L +    P D G + C     AG+     
Sbjct: 649 NPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQA 708

Query: 889 TVTITD----VSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWTKDGEEVVESPA 943
            +T+ +       W +  S    V A   + V+++C +   P+  V W +DG+ + +   
Sbjct: 709 VLTVQEPHDGTQPWFI--SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG 766

Query: 944 --LLLQKEDTVRRLVLPAVQLEDSGEY 968
              +LQ ED V  LVL  VQ   +G+Y
Sbjct: 767 HFEVLQNED-VFTLVLKKVQPWHAGQY 792



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 83/367 (22%), Positives = 137/367 (37%), Gaps = 40/367 (10%)

Query: 914  ERVVLTCELCR-PWAEVRWTKDGEEVVESPALLLQKEDTVRR-LVLPAVQLEDSGEYLCE 971
            + V   CE+   P  EV W  +G  V      +   ED     L L   +  DSG Y C 
Sbjct: 429  QTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCT 488

Query: 972  IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV-------LMCELSREDAP-VRWY 1023
              +     + + T    R+       +  +V  +C V       L C +     P + W 
Sbjct: 489  ASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWL 548

Query: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTV----T 1075
             +G  ++ + +     +     L +  A PED G + C A    G  S    VTV    +
Sbjct: 549  LNGQPIQYARSTC---EAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKS 605

Query: 1076 APPERIVHPAARSL-----------DLHFGAPGRVELRCEVAP-AGSQVRWYKDGLEVEA 1123
            +     + P A S            DL      +V +  +V+     +V W  +G E++ 
Sbjct: 606  SRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQE 665

Query: 1124 SDALQLGAEGPTRTLTLPHAQPEDAGEYVCE---TRHEAITFNVILAEPPVQFLA--LET 1178
            S+       G   +L +    PED G Y CE   +  E  T  V+  + P         +
Sbjct: 666  SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFIS 725

Query: 1179 TPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEG-LELHAEGPRRVLCIQAAG 1236
             P  +  + G+ V++SC ++    P V W  +G+ + +  G  E+        L ++   
Sbjct: 726  KPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQ 785

Query: 1237 PAHAGLY 1243
            P HAG Y
Sbjct: 786  PWHAGQY 792



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 88/381 (23%), Positives = 141/381 (37%), Gaps = 49/381 (12%)

Query: 1451 FLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH-DSRLSMAQDGHIHRLFI 1509
            F  + Q    +E Q V    E   +     V W   G P+   +  + + +D   H L +
Sbjct: 416  FESKPQSQEVKENQTVKFRCEVSGIPKP-EVAWFLEGTPVRRQEGSIEVYEDAGSHYLCL 474

Query: 1510 HGVILADQGTYGCESHHDR------------TLARLSVRPRQLRVLRPLEDVTISEGGSA 1557
                  D GTY C + + +             LA + V P    VL+   D  + EG   
Sbjct: 475  LKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLK---DCAVIEGQDF 531

Query: 1558 TFQLELSQEGVTG-EWARGGVQL-YPGPKC-------HIHS---DGHRHRLVLNGLGLAD 1605
              Q  +    V    W   G  + Y    C       HI     + H     L    L  
Sbjct: 532  VLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQ 591

Query: 1606 SGCVSFTADSLRCAARLIVREVPVT--------IVRGPHDLEVTEGDTATFECELS-QAL 1656
              C ++     + ++R     +PV          ++G  DL+V +G   T   ++S    
Sbjct: 592  VSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPP 651

Query: 1657 ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVR----L 1712
             +V W  +GN +  S     +  GT+  L ++   P D GTY+C    + AG VR    L
Sbjct: 652  PEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNS-AGEVRTQAVL 710

Query: 1713 TVRERTVAV----LSELRSVSAREGDGATFECTVS-EVETTGRWELGGRPL-RPGARVRI 1766
            TV+E         +S+ RSV+A  G      C ++ +   T  W   G+ L +      +
Sbjct: 711  TVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEV 770

Query: 1767 RQEGKKHILVLSELRAEDAGE 1787
             Q      LVL +++   AG+
Sbjct: 771  LQNEDVFTLVLKKVQPWHAGQ 791



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 82/336 (24%), Positives = 124/336 (36%), Gaps = 50/336 (14%)

Query: 1587 IHSDGHRHRLVLNGLGLADSGCVSFTADS----LRCA-----ARLIVREVPVTIVRGPHD 1637
            ++ D   H L L      DSG  S TA +    L C+      RL V EV  +      D
Sbjct: 463  VYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD 522

Query: 1638 LEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAG 1696
              V EG     +C +    +  +TW  +G    P    R         L ++   P D G
Sbjct: 523  CAVIEGQDFVLQCSVRGTPVPRITWLLNGQ---PIQYARSTCEAGVAELHIQDALPEDHG 579

Query: 1697 TYSCAVGTARAGPVR----LTVRERTVAVLSE------------------LRSVSAREGD 1734
            TY+C    A  G V     +TV E+  +  SE                  L  +   +G 
Sbjct: 580  TYTCLAENA-LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGS 638

Query: 1735 GATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG----EVR 1789
              T    VS        W   G  ++        Q G +H L + E+  ED G    E  
Sbjct: 639  QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAW 698

Query: 1790 FQAGPAQSLALLEVE-----ALPLQMCRHPPREKTVLVGRRAVLEVTVSRSG-GHVCWLR 1843
              AG  ++ A+L V+       P  + +  PR  T  +G+  ++   ++      V WLR
Sbjct: 699  NSAGEVRTQAVLTVQEPHDGTQPWFISK--PRSVTASLGQSVLISCAIAGDPFPTVHWLR 756

Query: 1844 EGAELCPG-DKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
            +G  LC     +E+  +    +LV+  V+P   G Y
Sbjct: 757  DGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY 792



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 30/92 (32%), Positives = 44/92 (47%), Gaps = 3/92 (3%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE--RLSFPADGAEHGL 69
            P F +  R + VV G+ A   C + G P P VVW K  Q +  S   ++ +  DG    L
Sbjct: 1758 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDG-NCSL 1816

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
            +++     D   Y C+A N+ GEA   A + V
Sbjct: 1817 IISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1848



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 28/91 (30%), Positives = 37/91 (40%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
           PP F      V V  G      C + G P P V W KG   L  S R+S         L 
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219

Query: 71  LTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
           +      D GVY C   N +G+A  +A +++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 3/133 (2%)

Query: 1153 CETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSR-AGAPVVWSHNGR 1211
            C+  H   T N   +E      A +     + VA G+ ++L C++S    A ++W+ NG+
Sbjct: 1077 CKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGK 1136

Query: 1212 PVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPV--RV 1269
             ++  + + L  EG    + I+ A P   GLY C +    G    S  V V + P     
Sbjct: 1137 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1196

Query: 1270 VAPEAAQTRVRST 1282
             APE    R +S+
Sbjct: 1197 KAPEMKSRRPKSS 1209



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 25/81 (30%), Positives = 37/81 (45%)

Query: 257  VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
            V EG  A+F C + G P+PE+ W  + + +   R   +  D DG   L +      D   
Sbjct: 1769 VVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAK 1828

Query: 317  YVCAARNSAGQTLSAVQLHVK 337
            Y C A NS G+     +L V+
Sbjct: 1829 YTCKAVNSLGEATCTAELIVE 1849



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 42/144 (29%), Positives = 61/144 (42%), Gaps = 23/144 (15%)

Query: 257  VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA--KDR 314
            V EGK    +C V   P   I W   G+ L   +  ++ ++   G +  V   +A  +DR
Sbjct: 1109 VAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQE---GSLCSVSIEKALPEDR 1165

Query: 315  GLYVCAARNSAGQTLSAVQLHV---------KEPRLRFTRP---LQDVEGREHGIAVLEC 362
            GLY C A+N AGQ   + Q+ V         K P ++  RP   L  V G E    V + 
Sbjct: 1166 GLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKK 1225

Query: 363  KVPNSRIPTAW------FREDQRL 380
              P +    A       F EDQ++
Sbjct: 1226 PAPKTPPKAAMPPQIIQFPEDQKV 1249



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 45/171 (26%), Positives = 67/171 (39%), Gaps = 14/171 (8%)

Query: 1723 SELRSVSAREGDGATFECTVSEV-ETTGRWELGGRPLR-PGARVRIRQEGKKHILVLSEL 1780
            S+ +S   +E     F C VS + +    W L G P+R     + + ++   H L L + 
Sbjct: 418  SKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKA 477

Query: 1781 RAEDAGEVRFQAGPAQSLA----LLEVEALPLQMCRHP----PREKTVLVGRRAVLEVTV 1832
            R  D+G     A  AQ        L+VE L +           ++  V+ G+  VL+ +V
Sbjct: 478  RTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSV 537

Query: 1833 SRSG-GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
              +    + WL  G    P              L I D  PED GTY C A
Sbjct: 538  RGTPVPRITWLLNGQ---PIQYARSTCEAGVAELHIQDALPEDHGTYTCLA 585



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 1/102 (0%)

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
            AG+T    R   + T   F ++LQDV   EG+ + L+ +      A  + W   G+ L  
Sbjct: 1082 AGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATII-WTLNGKTLKT 1140

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLS 1534
               + ++Q+G +  + I   +  D+G Y C + +D   A  S
Sbjct: 1141 TKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1182



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 49/201 (24%), Positives = 72/201 (35%), Gaps = 42/201 (20%)

Query: 1626 EVPVTIVRGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQA--LGTR 1682
            E P  I+  P +L + EG TA FE  +       VTW ++G  +T   R  L     GT 
Sbjct: 31   EAPAFILP-PRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTF 89

Query: 1683 RLLQLRRCGPSDAGTYSCAVGT---ARAGPVRLTVRERTVAVLSE--------------- 1724
             L+ +      D G Y+C       AR   V LTV       L +               
Sbjct: 90   SLV-IHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPA 148

Query: 1725 ------------------LRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVR 1765
                              L  V  +EG    F C ++   +    W  G  PL+P ARV 
Sbjct: 149  VETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVS 208

Query: 1766 IRQEGKKHILVLSELRAEDAG 1786
            + ++    +L +  +  +D G
Sbjct: 209  VSEKNGMQVLEIHGVNQDDVG 229



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 33/100 (33%), Positives = 43/100 (43%), Gaps = 7/100 (7%)

Query: 1797 SLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYE 1855
            S+ L E  A  L     PPR   +  G  A  E  V       V W R G  +  G ++ 
Sbjct: 26   SMPLTEAPAFIL-----PPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFL 80

Query: 1856 MRSH-GPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
            +      T SLVIH V  ED+G Y C+A   S   ++ VE
Sbjct: 81   LDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 27/99 (27%), Positives = 44/99 (44%), Gaps = 4/99 (4%)

Query: 1640 VTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            V EG    F C+++ +    VTW K    L PS R+ +      ++L++      D G Y
Sbjct: 172  VKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVY 231

Query: 1699 SCAV--GTARAG-PVRLTVRERTVAVLSELRSVSAREGD 1734
            +C V  G+ +A     L+++    A  S +R   A   D
Sbjct: 232  TCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD 270



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 22/77 (28%), Positives = 40/77 (51%), Gaps = 5/77 (6%)

Query: 1007 VVLMCELSRED-APVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC---- 1061
            ++L C++S +  A + W  +G  ++ ++ ++L ++G  C + +  A PED G + C    
Sbjct: 1115 LLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKN 1174

Query: 1062 DAGDDSAFFTVTVTAPP 1078
            DAG       VTV   P
Sbjct: 1175 DAGQAECSCQVTVDDAP 1191



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 24/126 (19%)

Query: 343  FTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRKYE-QIEEGTVRRLIIH 400
            F++ ++D+E  E   A  +CK+     P   WF++DQ +   R ++   +E     LII 
Sbjct: 1760 FSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIIS 1819

Query: 401  RLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR 460
             +  DDD  Y C+    V ++   T                    A L+VET+E G EG 
Sbjct: 1820 DVCGDDDAKYTCK---AVNSLGEATC------------------TAELIVETMEEG-EGE 1857

Query: 461  WSRDGE 466
               + E
Sbjct: 1858 GEEEEE 1863



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 1/85 (1%)

Query: 9   GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA-SERLSFPADGAEH 67
           G+ P F+  PR V    G    + C + G+P P V W + G+ L   +       +    
Sbjct: 718 GTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVF 777

Query: 68  GLLLTAALPTDAGVYVCRARNAAGE 92
            L+L    P  AG Y    +N  GE
Sbjct: 778 TLVLKKVQPWHAGQYEILLKNRVGE 802



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%)

Query: 817  VHAITSECVMLACEVDRED-APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            VH    + ++L C+V  +  A + W  +G+ ++ + F++L  EG    + +    P D G
Sbjct: 1107 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRG 1166

Query: 876  EFQCVAGDE 884
             ++CVA ++
Sbjct: 1167 LYKCVAKND 1175



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 34/112 (30%), Positives = 45/112 (40%), Gaps = 8/112 (7%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P F    R   V+ G+     C+  G P+P + W KD  ++ E   S HF  Q    EDG
Sbjct: 1758 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRE---SRHF--QIDYDEDG 1812

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE 239
               + +L I      D   Y C A N+ G A   A L V    E      +E
Sbjct: 1813 ---NCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEE 1861



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 18/71 (25%), Positives = 38/71 (53%), Gaps = 1/71 (1%)

Query: 1090 DLHFGAPGRVELRCEVAP-AGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDA 1148
            D+H     ++ L+C+V+    + + W  +G  ++ +  + L  EG   ++++  A PED 
Sbjct: 1106 DVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR 1165

Query: 1149 GEYVCETRHEA 1159
            G Y C  +++A
Sbjct: 1166 GLYKCVAKNDA 1176



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 5/62 (8%)

Query: 925 PWAEVRWTKDGEEVVESPALLLQKEDTVR---RLVLPAVQLEDSGEYLCEIDDESASFTV 981
           P  +V W ++G+ +      LL  +  +R    LV+ AV  ED G+Y CE  + S +  V
Sbjct: 60  PEPQVTWHRNGQPITSGGRFLL--DCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQV 117

Query: 982 TV 983
           TV
Sbjct: 118 TV 119



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/65 (26%), Positives = 29/65 (44%), Gaps = 1/65 (1%)

Query: 1637 DLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
            D+ V EG     +C++S    A + W  +G  L  +  + L   G+   + + +  P D 
Sbjct: 1106 DVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR 1165

Query: 1696 GTYSC 1700
            G Y C
Sbjct: 1166 GLYKC 1170



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 4/67 (5%)

Query: 1637 DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRL--QALGTRRLLQLRRCGPS 1693
            DLEV EG  A F+C++      +V W KD  ++  S   ++     G   L+    CG  
Sbjct: 1766 DLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDD 1825

Query: 1694 DAGTYSC 1700
            DA  Y+C
Sbjct: 1826 DA-KYTC 1831


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score =  110 bits (276), Expect = 1e-23
 Identities = 92/332 (27%), Positives = 138/332 (41%), Gaps = 29/332 (8%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLL 71
           P F    +   V+ G +  L+C V G P P + W   GQ +  + R +  A  AE  L +
Sbjct: 514 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYA-RSTCEAGVAE--LHI 570

Query: 72  TAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFL 131
             ALP D G Y C A NA G+   +A VTV E  +S    + +E  LP   S   AP+FL
Sbjct: 571 QDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSS----RKSEYLLPVAPSKPTAPIFL 626

Query: 132 TGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS 191
            G     V+ G++V +T +  G P P + W  +G  + E  D  HF        +  G  
Sbjct: 627 QGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHF--------EQRGTQ 677

Query: 192 LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP-LKC 250
            +L I      D+G Y C A N+ G  +  A+L V +P +              +P    
Sbjct: 678 HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDG------------TQPWFIS 725

Query: 251 APKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQ 310
            P++   + G+     C + G P P + W  +G+ L  D         +  F L +   Q
Sbjct: 726 KPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQ 785

Query: 311 AKDRGLYVCAARNSAGQTLSAVQLHVKEPRLR 342
               G Y    +N  G+    V L ++    R
Sbjct: 786 PWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 817



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 105/426 (24%), Positives = 156/426 (36%), Gaps = 58/426 (13%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE-RLSFPADGAEHGLL 70
           P F   P+   V      + +C V G P P V W   G  +   E  +    D   H L 
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473

Query: 71  LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVF 130
           L  A   D+G Y C A NA G+   +  + V                       E AP F
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVM-----------------EVAPSF 516

Query: 131 LTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA 190
            +  +   V+ G + VL C   G P P + W  +G  +      +    + G AE     
Sbjct: 517 SSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI----QYARSTCEAGVAE----- 567

Query: 191 SLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP------PADPDEAPAPV 244
              L I  A   D G Y C A NA G     A + VH+   S       P  P +  AP+
Sbjct: 568 ---LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPI 624

Query: 245 ----VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDG 300
               +  LK       V +G        V G P PE+ W   G   + +     +  R  
Sbjct: 625 FLQGLSDLK-------VMDGSQVTMTVQVSGNPPPEVIWLHNGNE-IQESEDFHFEQRGT 676

Query: 301 GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP----RLRFTRPLQDVEGREHG 356
              L +     +D G Y C A NSAG+  +   L V+EP    +  F    + V      
Sbjct: 677 QHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQ 736

Query: 357 IAVLECKVPNSRIPTA-WFREDQRLLPCR---KYEQIEEGTVRRLIIHRLKADDDGIYLC 412
             ++ C +     PT  W R+ + L  C+    +E ++   V  L++ +++    G Y  
Sbjct: 737 SVLISCAIAGDPFPTVHWLRDGKAL--CKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEI 794

Query: 413 EMRGRV 418
            ++ RV
Sbjct: 795 LLKNRV 800



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 167/734 (22%), Positives = 269/734 (36%), Gaps = 109/734 (14%)

Query: 838  VRWYKDGQEVEESDFVVLEN--EGPHRRLVLPATQPSDGGEFQCVA--GDECAYFTVTIT 893
            V W+++GQ +      +L+    G    LV+ A    D G++ C A  G      TV +T
Sbjct: 64   VTWHRNGQPITSGGRFLLDCGIRGTFS-LVIHAVHEEDRGKYTCEATNGSGARQVTVELT 122

Query: 894  DVSSW--------IVYPSGKVYVA-----------------AVRLERVVL--------TC 920
               S+        +    G  + A                 A +L RVV+        +C
Sbjct: 123  VEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSC 182

Query: 921  ELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASF 979
            ++  RP  +V W K    +  S  + + +++ ++ L +  V  +D G Y C + + S   
Sbjct: 183  KITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKA 242

Query: 980  TVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLER 1039
            +++        I   D      V  E      ++ +E   V   +  L+  E+ A     
Sbjct: 243  SMSAELS----IQGLDSANRSFVR-ETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNC 297

Query: 1040 DGPRCRLVLPAA---QPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAP 1096
              P+     P A   QP+   E   ++  DS       TAP   ++   + S+ L     
Sbjct: 298  SSPQRGGSPPWAANSQPQPPRESKLESCKDSPR-----TAPQTPVLQKTSSSITLQAA-- 350

Query: 1097 GRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPE-DAGEYVCET 1155
                 R +  P          GL V +    +     P R  T P  QP   + + V + 
Sbjct: 351  -----RVQPEPRAP-------GLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKA 398

Query: 1156 RHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQ 1214
             +  I       +    F   E+ P    V   + V   CE+S    P V W   G PV+
Sbjct: 399  ANRRIPME---GQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVR 455

Query: 1215 EGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPE 1273
              EG +E++ +     LC+  A    +G Y+C +  A G  S S+T+QV    V  VAP 
Sbjct: 456  RQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPS 515

Query: 1274 AAQTRVRSTPGGDLELVVHLSGPGGPV---RWYKDGERLASQGRVQLEQAGARQVLRVQG 1330
             +            + V+  S  G PV    W  +G+ +  Q      +AG  + L +Q 
Sbjct: 516  FSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI--QYARSTCEAGVAE-LHIQD 572

Query: 1331 ARSGDAGEYLC---------------------DAPQDSRIFLVSVEEPLLVKLVSELTPL 1369
            A   D G Y C                      + +   +  V+  +P     +  L+ L
Sbjct: 573  ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 632

Query: 1370 TVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGT 1428
             V +G   T   +VS  P  +V WL NG  +         Q G+   L ++     D GT
Sbjct: 633  KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGT 692

Query: 1429 VTLR----AGSTATSARLHVRE----TELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGA 1480
             T      AG   T A L V+E    T+  F+ + + V A  GQ V +            
Sbjct: 693  YTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAG-DPFPT 751

Query: 1481 VRWVRGGQPLPHDS 1494
            V W+R G+ L  D+
Sbjct: 752  VHWLRDGKALCKDT 765



 Score = 92.0 bits (227), Expect = 5e-18
 Identities = 112/424 (26%), Positives = 156/424 (36%), Gaps = 77/424 (18%)

Query: 105 PASDPELQP-----------AERPLPSPGSGEGA-PVFLTGPRSQWVLRGAEVVLTCRAG 152
           PA+ P  QP           A R +P  G  + A P F + P+SQ V     V   C   
Sbjct: 379 PATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVS 438

Query: 153 GLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGA-SLALRILAARLPDSGVYVCHA 211
           G+P+P + W  +G  +           Q G  E    A S  L +L AR  DSG Y C A
Sbjct: 439 GIPKPEVAWFLEGTPVRR---------QEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTA 489

Query: 212 RNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMG 271
            NA G       LQV +           A   V        K   V EG+    +C V G
Sbjct: 490 SNAQGQLSCSWTLQVER----------LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRG 539

Query: 272 KPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSA 331
            P P I W   G+P+   R         G   L +     +D G Y C A N+ GQ   +
Sbjct: 540 TPVPRITWLLNGQPIQYARSTC----EAGVAELHIQDALPEDHGTYTCLAENALGQVSCS 595

Query: 332 VQLHVKEPRLR------------------FTRPLQDVEGREHGIAVLECKVPNSRIP-TA 372
             + V E +                    F + L D++  +     +  +V  +  P   
Sbjct: 596 AWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVI 655

Query: 373 WFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTVKGP 429
           W      +     +   + GT   L I  +  +D G Y CE     G VRT A +TV+ P
Sbjct: 656 WLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP 715

Query: 430 --------ILKRLPRKLDVLEGENAVLLVETLEAG---VEGRWSRDGEELPVICQSSSGH 478
                   I K  PR +    G++  +L+    AG       W RDG+ L   C+  +GH
Sbjct: 716 HDGTQPWFISK--PRSVTASLGQS--VLISCAIAGDPFPTVHWLRDGKAL---CK-DTGH 767

Query: 479 MHAL 482
              L
Sbjct: 768 FEVL 771



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/257 (28%), Positives = 109/257 (42%), Gaps = 33/257 (12%)

Query: 5    SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADG 64
            S  QG+ P F +  + V V  G +  L+C V  +PP  ++W   G+ L  ++ +    +G
Sbjct: 1091 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEG 1150

Query: 65   AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASD----PELQP------- 113
            +   + +  ALP D G+Y C A+N AG+A  +  VTV + PAS+    PE++        
Sbjct: 1151 SLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSL 1210

Query: 114  ------------AERPLP-SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLY 160
                         ++P P +P      P  +  P  Q V  G  V L  +  G    T  
Sbjct: 1211 PPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCT 1270

Query: 161  WEKDGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQA 220
            W K      ++ +S H  ++   +E+G      L ILAAR    G Y     N  G  QA
Sbjct: 1271 WMK---FRKQIQESEHMKVE--NSENGS----KLTILAARQEHCGCYTLLVENKLGSRQA 1321

Query: 221  GALLQVHQPPESPPADP 237
               L V   P+ P   P
Sbjct: 1322 QVNLTVVDKPDPPAGTP 1338



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 169/755 (22%), Positives = 266/755 (35%), Gaps = 164/755 (21%)

Query: 1065 DDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS 1124
            D S   ++ +T  P  I+ P  R+L +  GA  + E R    P   QV W+++G  + + 
Sbjct: 20   DPSRVDSMPLTEAPAFILPP--RNLCIKEGATAKFEGRVRGYPE-PQVTWHRNGQPITSG 76

Query: 1125 DA--LQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVI------------LAEPP 1170
                L  G  G T +L +     ED G+Y CE  + +    V             L +P 
Sbjct: 77   GRFLLDCGIRG-TFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPV 135

Query: 1171 VQFL--------ALETTPS--------------PLCVAPGEPVVLSCELSRAGAP-VVWS 1207
            V           A+ET PS               + V  G+    SC+++    P V W 
Sbjct: 136  VSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWL 195

Query: 1208 HNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC--QSGAAPGAPSLSFTVQ---- 1261
                P+Q    + +  +   +VL I        G+YTC   +G+   + S   ++Q    
Sbjct: 196  KGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDS 255

Query: 1262 ---------------VAEPPVRVVAPE--------AAQTRVRSTP--GGDLELVVHLSGP 1296
                           V +    V++ E        AA+++  S+P  GG      + S P
Sbjct: 256  ANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAAN-SQP 314

Query: 1297 GGP----VRWYKDGERLASQGRVQLEQAGA--RQVLRVQ--------GARSGDAGEYLCD 1342
              P    +   KD  R A Q  V  + + +   Q  RVQ        G  S    E    
Sbjct: 315  QPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRP 374

Query: 1343 AP----------------------QDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFR 1380
            AP                       + RI +    +    K  S+     V E     FR
Sbjct: 375  APPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFR 434

Query: 1381 CEVSP-PDADVTWLRNGAVV-TPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGS--- 1435
            CEVS  P  +V W   G  V      +E+ ++  S  L L   +  D+GT +  A +   
Sbjct: 435  CEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQG 494

Query: 1436 ------TATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQP 1489
                  T    RL V E    F   L+D    EGQD  L+    R      + W+  GQP
Sbjct: 495  QLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSV-RGTPVPRITWLLNGQP 553

Query: 1490 LPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESH--------------HDRTLARLS- 1534
            + +      A    +H   I   +  D GTY C +               H++  +R S 
Sbjct: 554  IQYARSTCEAGVAELH---IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSE 610

Query: 1535 -------VRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGE-WARGGVQLYPGPKCH 1586
                    +P     L+ L D+ + +G   T  +++S        W   G ++      H
Sbjct: 611  YLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH 670

Query: 1587 IHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHD--------- 1637
                G +H L +  +   D+G  ++T ++   A    VR   V  V+ PHD         
Sbjct: 671  FEQRGTQHSLCIQEVFPEDTG--TYTCEAWNSAGE--VRTQAVLTVQEPHDGTQPWFISK 726

Query: 1638 ---LEVTEGDTATFECELS-QALADVTWEKDGNAL 1668
               +  + G +    C ++      V W +DG AL
Sbjct: 727  PRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKAL 761



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 64/229 (27%), Positives = 96/229 (41%), Gaps = 27/229 (11%)

Query: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
           AP F+  PR+  +  GA      R  G PEP + W ++G  +        F L     + 
Sbjct: 32  APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS---GGRFLL-----DC 83

Query: 187 GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALL--------QVHQPPESPP-ADP 237
           G   + +L I A    D G Y C A N  G  Q    L        Q+ QP  S    D 
Sbjct: 84  GIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDR 143

Query: 238 DEAPAPVVEPL---KCAPK------TFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
             APA    P    +C PK         V EG+  +F C + G+P+P++ W     PL P
Sbjct: 144 FSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQP 203

Query: 289 DRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK 337
              R+   +++G  VL++      D G+Y C   N +G+   + +L ++
Sbjct: 204 S-ARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 82/297 (27%), Positives = 114/297 (38%), Gaps = 40/297 (13%)

Query: 252 PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA 311
           P++  V E +  KFRC V G P+PE+ W  EG P+      +   +  G   L +L  + 
Sbjct: 420 PQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKART 479

Query: 312 KDRGLYVCAARNSAGQ-----TLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKVPN 366
           +D G Y C A N+ GQ     TL   +L V E    F+  L+D    E    VL+C V  
Sbjct: 480 RDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRG 539

Query: 367 SRIP-TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVA 422
           + +P   W    Q   P +      E  V  L I     +D G Y C      G+V   A
Sbjct: 540 TPVPRITWLLNGQ---PIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSA 596

Query: 423 NVTV--------------------KGPILKRLPRKLDVLEGENAVLLVETL-EAGVEGRW 461
            VTV                      PI  +    L V++G    + V+       E  W
Sbjct: 597 WVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIW 656

Query: 462 SRDGEELPV---ICQSSSGHMHALVLPGVTREDAGEVTF----SLGNSRTTTLLRVK 511
             +G E+           G  H+L +  V  ED G  T     S G  RT  +L V+
Sbjct: 657 LHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ 713



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 89/371 (23%), Positives = 146/371 (39%), Gaps = 43/371 (11%)

Query: 1005 ECVVLMCELSREDAP-VRWYKDGLEVEESEALV-LERDGPRCRLVLPAAQPEDGGEFVCD 1062
            + V   CE+S    P V W+ +G  V   E  + +  D     L L  A+  D G + C 
Sbjct: 429  QTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCT 488

Query: 1063 AGDDSAFFTVTVTAPPERI----VHPAARSL--DLHFGAPGRVELRCEVAPAG-SQVRWY 1115
            A +     + + T   ER+    V P+  S+  D          L+C V      ++ W 
Sbjct: 489  ASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWL 548

Query: 1116 KDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA--------ITFNVILA 1167
             +G  ++ + +     E     L +  A PED G Y C   +          +T +   +
Sbjct: 549  LNGQPIQYARST---CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKS 605

Query: 1168 EPPVQFL-----ALETTP------SPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQE 1215
                ++L     +  T P      S L V  G  V ++ ++S    P V+W HNG  +QE
Sbjct: 606  SRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQE 665

Query: 1216 GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEP-----PVRVV 1270
             E       G +  LCIQ   P   G YTC++  + G       + V EP     P  + 
Sbjct: 666  SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFIS 725

Query: 1271 APEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQ-GRVQLEQAGARQVLRV 1328
             P +    V ++ G  + +   ++G P   V W +DG+ L    G  ++ Q      L +
Sbjct: 726  KPRS----VTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVL 781

Query: 1329 QGARSGDAGEY 1339
            +  +   AG+Y
Sbjct: 782  KKVQPWHAGQY 792



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 57/232 (24%), Positives = 88/232 (37%), Gaps = 37/232 (15%)

Query: 234 PADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRL 293
           P+  D  P          P+   + EG  AKF   V G PEP++ WH  G+P+    R L
Sbjct: 21  PSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFL 80

Query: 294 MYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK---------------- 337
           +     G F L +     +DRG Y C A N +G     V+L V+                
Sbjct: 81  LDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTL 140

Query: 338 -----------------EPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQR 379
                            E   +F   L  V  +E  +    CK+     P   W + +  
Sbjct: 141 GDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVP 200

Query: 380 LLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEM---RGRVRTVANVTVKG 428
           L P  +    E+  ++ L IH +  DD G+Y C +    G+    A ++++G
Sbjct: 201 LQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG 252



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 70/298 (23%), Positives = 107/298 (35%), Gaps = 54/298 (18%)

Query: 1635 PHDLEVTEGDTATFECELSQA-LADVTWEKDGNALTPSPR----LRLQALGTRRLLQLRR 1689
            P   EV E  T  F CE+S     +V W  +G   TP  R    + +        L L +
Sbjct: 420  PQSQEVKENQTVKFRCEVSGIPKPEVAWFLEG---TPVRRQEGSIEVYEDAGSHYLCLLK 476

Query: 1690 CGPSDAGTYSCAVGTARAG--------PVRLTVRERTVAVLSELRSVSAREGDGATFECT 1741
                D+GTYSC    A+            RL V E   +  S L+  +  EG     +C+
Sbjct: 477  ARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCS 536

Query: 1742 VSEVETTG-RWELGGRPLRPGARVRIRQEGKKHI-------------------------- 1774
            V         W L G+P++           + HI                          
Sbjct: 537  VRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSA 596

Query: 1775 -LVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVS 1833
             + + E ++    E      P++  A + ++ L          +  V+ G +  + V VS
Sbjct: 597  WVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS---------DLKVMDGSQVTMTVQVS 647

Query: 1834 RSGG-HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTR 1890
             +    V WL  G E+   + +     G  HSL I +V PED GTY C+A   +   R
Sbjct: 648  GNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVR 705



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 63/232 (27%), Positives = 83/232 (35%), Gaps = 31/232 (13%)

Query: 12  PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG--- 68
           P F+  PR + +  GA A+ +  V G P P V W + GQ + +  R  F  D    G   
Sbjct: 33  PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGR--FLLDCGIRGTFS 90

Query: 69  LLLTAALPTDAGVYVCRARNAAGEAYAAAAVT------------VLEPPASDPELQPAER 116
           L++ A    D G Y C A N +G       +T            V+     D    PA  
Sbjct: 91  LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVE 150

Query: 117 PLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSH 176
             PS   GE  P F T      V  G     +C+  G P+P + W K            +
Sbjct: 151 TRPSIW-GECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLK-----------GN 198

Query: 177 FALQPGR--AEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV 226
             LQP    +         L I      D GVY C   N  G A   A L +
Sbjct: 199 VPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 90/387 (23%), Positives = 150/387 (38%), Gaps = 62/387 (16%)

Query: 626 QVYDGEDAVFSLDLSTIIQG--TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLIL 683
           +V + +   F  ++S I +    WFL G  ++  E  G +E       + +    H L L
Sbjct: 424 EVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQE--GSIE-------VYEDAGSHYLCL 474

Query: 684 HAVKHQDSGALVGFSCPGV----QDSAALTIQESPVHILSPQDRVSLTFTT-----SERV 734
              + +DSG    +SC       Q S + T+Q   + ++      S           +  
Sbjct: 475 LKARTRDSGT---YSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDF 531

Query: 735 VLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG- 792
           VL C +     P  TW  +GQ ++ +           H   + +A  +D G + C  E  
Sbjct: 532 VLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH---IQDALPEDHGTYTCLAENA 588

Query: 793 ---VSAFFGVTVQDP----------PVHIVDPREHVFVHAITSECVM------LACEVDR 833
              VS    VTV +           PV    P   +F+  ++   VM      +  +V  
Sbjct: 589 LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSG 648

Query: 834 EDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC----VAGDECAYF 888
              P V W  +G E++ES+    E  G    L +    P D G + C     AG+     
Sbjct: 649 NPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQA 708

Query: 889 TVTITD----VSSWIVYPSGKVYVAAVRLERVVLTCELC-RPWAEVRWTKDGEEVVESPA 943
            +T+ +       W +  S    V A   + V+++C +   P+  V W +DG+ + +   
Sbjct: 709 VLTVQEPHDGTQPWFI--SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG 766

Query: 944 --LLLQKEDTVRRLVLPAVQLEDSGEY 968
              +LQ ED V  LVL  VQ   +G+Y
Sbjct: 767 HFEVLQNED-VFTLVLKKVQPWHAGQY 792



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 83/367 (22%), Positives = 137/367 (37%), Gaps = 40/367 (10%)

Query: 914  ERVVLTCELCR-PWAEVRWTKDGEEVVESPALLLQKEDTVRR-LVLPAVQLEDSGEYLCE 971
            + V   CE+   P  EV W  +G  V      +   ED     L L   +  DSG Y C 
Sbjct: 429  QTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCT 488

Query: 972  IDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVV-------LMCELSREDAP-VRWY 1023
              +     + + T    R+       +  +V  +C V       L C +     P + W 
Sbjct: 489  ASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWL 548

Query: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTVTV----T 1075
             +G  ++ + +     +     L +  A PED G + C A    G  S    VTV    +
Sbjct: 549  LNGQPIQYARSTC---EAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKS 605

Query: 1076 APPERIVHPAARSL-----------DLHFGAPGRVELRCEVAP-AGSQVRWYKDGLEVEA 1123
            +     + P A S            DL      +V +  +V+     +V W  +G E++ 
Sbjct: 606  SRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQE 665

Query: 1124 SDALQLGAEGPTRTLTLPHAQPEDAGEYVCE---TRHEAITFNVILAEPPVQFLA--LET 1178
            S+       G   +L +    PED G Y CE   +  E  T  V+  + P         +
Sbjct: 666  SEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFIS 725

Query: 1179 TPSPLCVAPGEPVVLSCELSRAGAPVV-WSHNGRPVQEGEG-LELHAEGPRRVLCIQAAG 1236
             P  +  + G+ V++SC ++    P V W  +G+ + +  G  E+        L ++   
Sbjct: 726  KPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQ 785

Query: 1237 PAHAGLY 1243
            P HAG Y
Sbjct: 786  PWHAGQY 792



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 88/381 (23%), Positives = 141/381 (37%), Gaps = 49/381 (12%)

Query: 1451 FLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH-DSRLSMAQDGHIHRLFI 1509
            F  + Q    +E Q V    E   +     V W   G P+   +  + + +D   H L +
Sbjct: 416  FESKPQSQEVKENQTVKFRCEVSGIPKP-EVAWFLEGTPVRRQEGSIEVYEDAGSHYLCL 474

Query: 1510 HGVILADQGTYGCESHHDR------------TLARLSVRPRQLRVLRPLEDVTISEGGSA 1557
                  D GTY C + + +             LA + V P    VL+   D  + EG   
Sbjct: 475  LKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLK---DCAVIEGQDF 531

Query: 1558 TFQLELSQEGVTG-EWARGGVQL-YPGPKC-------HIHS---DGHRHRLVLNGLGLAD 1605
              Q  +    V    W   G  + Y    C       HI     + H     L    L  
Sbjct: 532  VLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQ 591

Query: 1606 SGCVSFTADSLRCAARLIVREVPVT--------IVRGPHDLEVTEGDTATFECELS-QAL 1656
              C ++     + ++R     +PV          ++G  DL+V +G   T   ++S    
Sbjct: 592  VSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPP 651

Query: 1657 ADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVR----L 1712
             +V W  +GN +  S     +  GT+  L ++   P D GTY+C    + AG VR    L
Sbjct: 652  PEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNS-AGEVRTQAVL 710

Query: 1713 TVRERTVAV----LSELRSVSAREGDGATFECTVS-EVETTGRWELGGRPL-RPGARVRI 1766
            TV+E         +S+ RSV+A  G      C ++ +   T  W   G+ L +      +
Sbjct: 711  TVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEV 770

Query: 1767 RQEGKKHILVLSELRAEDAGE 1787
             Q      LVL +++   AG+
Sbjct: 771  LQNEDVFTLVLKKVQPWHAGQ 791



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 82/336 (24%), Positives = 124/336 (36%), Gaps = 50/336 (14%)

Query: 1587 IHSDGHRHRLVLNGLGLADSGCVSFTADS----LRCA-----ARLIVREVPVTIVRGPHD 1637
            ++ D   H L L      DSG  S TA +    L C+      RL V EV  +      D
Sbjct: 463  VYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD 522

Query: 1638 LEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAG 1696
              V EG     +C +    +  +TW  +G    P    R         L ++   P D G
Sbjct: 523  CAVIEGQDFVLQCSVRGTPVPRITWLLNGQ---PIQYARSTCEAGVAELHIQDALPEDHG 579

Query: 1697 TYSCAVGTARAGPVR----LTVRERTVAVLSE------------------LRSVSAREGD 1734
            TY+C    A  G V     +TV E+  +  SE                  L  +   +G 
Sbjct: 580  TYTCLAENA-LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGS 638

Query: 1735 GATFECTVS-EVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG----EVR 1789
              T    VS        W   G  ++        Q G +H L + E+  ED G    E  
Sbjct: 639  QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAW 698

Query: 1790 FQAGPAQSLALLEVE-----ALPLQMCRHPPREKTVLVGRRAVLEVTVSRSG-GHVCWLR 1843
              AG  ++ A+L V+       P  + +  PR  T  +G+  ++   ++      V WLR
Sbjct: 699  NSAGEVRTQAVLTVQEPHDGTQPWFISK--PRSVTASLGQSVLISCAIAGDPFPTVHWLR 756

Query: 1844 EGAELCPG-DKYEMRSHGPTHSLVIHDVRPEDQGTY 1878
            +G  LC     +E+  +    +LV+  V+P   G Y
Sbjct: 757  DGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY 792



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 30/92 (32%), Positives = 44/92 (47%), Gaps = 3/92 (3%)

Query: 12   PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASE--RLSFPADGAEHGL 69
            P F +  R + VV G+ A   C + G P P VVW K  Q +  S   ++ +  DG    L
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDG-NCSL 1867

Query: 70   LLTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
            +++     D   Y C+A N+ GEA   A + V
Sbjct: 1868 IISDVCGDDDAKYTCKAVNSLGEATCTAELIV 1899



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 28/91 (30%), Positives = 37/91 (40%)

Query: 11  PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 70
           PP F      V V  G      C + G P P V W KG   L  S R+S         L 
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219

Query: 71  LTAALPTDAGVYVCRARNAAGEAYAAAAVTV 101
           +      D GVY C   N +G+A  +A +++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 3/133 (2%)

Query: 1153 CETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSR-AGAPVVWSHNGR 1211
            C+  H   T N   +E      A +     + VA G+ ++L C++S    A ++W+ NG+
Sbjct: 1077 CKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGK 1136

Query: 1212 PVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPV--RV 1269
             ++  + + L  EG    + I+ A P   GLY C +    G    S  V V + P     
Sbjct: 1137 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1196

Query: 1270 VAPEAAQTRVRST 1282
             APE    R +S+
Sbjct: 1197 KAPEMKSRRPKSS 1209



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 25/81 (30%), Positives = 37/81 (45%)

Query: 257  VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
            V EG  A+F C + G P+PE+ W  + + +   R   +  D DG   L +      D   
Sbjct: 1820 VVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAK 1879

Query: 317  YVCAARNSAGQTLSAVQLHVK 337
            Y C A NS G+     +L V+
Sbjct: 1880 YTCKAVNSLGEATCTAELIVE 1900



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 42/144 (29%), Positives = 61/144 (42%), Gaps = 23/144 (15%)

Query: 257  VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQA--KDR 314
            V EGK    +C V   P   I W   G+ L   +  ++ ++   G +  V   +A  +DR
Sbjct: 1109 VAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQE---GSLCSVSIEKALPEDR 1165

Query: 315  GLYVCAARNSAGQTLSAVQLHV---------KEPRLRFTRP---LQDVEGREHGIAVLEC 362
            GLY C A+N AGQ   + Q+ V         K P ++  RP   L  V G E    V + 
Sbjct: 1166 GLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKK 1225

Query: 363  KVPNSRIPTAW------FREDQRL 380
              P +    A       F EDQ++
Sbjct: 1226 PAPKTPPKAAMPPQIIQFPEDQKV 1249



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 45/171 (26%), Positives = 67/171 (39%), Gaps = 14/171 (8%)

Query: 1723 SELRSVSAREGDGATFECTVSEV-ETTGRWELGGRPLR-PGARVRIRQEGKKHILVLSEL 1780
            S+ +S   +E     F C VS + +    W L G P+R     + + ++   H L L + 
Sbjct: 418  SKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKA 477

Query: 1781 RAEDAGEVRFQAGPAQSLA----LLEVEALPLQMCRHP----PREKTVLVGRRAVLEVTV 1832
            R  D+G     A  AQ        L+VE L +           ++  V+ G+  VL+ +V
Sbjct: 478  RTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSV 537

Query: 1833 SRSG-GHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
              +    + WL  G    P              L I D  PED GTY C A
Sbjct: 538  RGTPVPRITWLLNGQ---PIQYARSTCEAGVAELHIQDALPEDHGTYTCLA 585



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 1/102 (0%)

Query: 1433 AGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPH 1492
            AG+T    R   + T   F ++LQDV   EG+ + L+ +      A  + W   G+ L  
Sbjct: 1082 AGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATII-WTLNGKTLKT 1140

Query: 1493 DSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLS 1534
               + ++Q+G +  + I   +  D+G Y C + +D   A  S
Sbjct: 1141 TKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1182



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 49/201 (24%), Positives = 72/201 (35%), Gaps = 42/201 (20%)

Query: 1626 EVPVTIVRGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQA--LGTR 1682
            E P  I+  P +L + EG TA FE  +       VTW ++G  +T   R  L     GT 
Sbjct: 31   EAPAFILP-PRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTF 89

Query: 1683 RLLQLRRCGPSDAGTYSCAVGT---ARAGPVRLTVRERTVAVLSE--------------- 1724
             L+ +      D G Y+C       AR   V LTV       L +               
Sbjct: 90   SLV-IHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPA 148

Query: 1725 ------------------LRSVSAREGDGATFECTVS-EVETTGRWELGGRPLRPGARVR 1765
                              L  V  +EG    F C ++   +    W  G  PL+P ARV 
Sbjct: 149  VETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVS 208

Query: 1766 IRQEGKKHILVLSELRAEDAG 1786
            + ++    +L +  +  +D G
Sbjct: 209  VSEKNGMQVLEIHGVNQDDVG 229



 Score = 38.9 bits (89), Expect = 0.048
 Identities = 33/100 (33%), Positives = 43/100 (43%), Gaps = 7/100 (7%)

Query: 1797 SLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRSGGHVCWLREGAELCPGDKYE 1855
            S+ L E  A  L     PPR   +  G  A  E  V       V W R G  +  G ++ 
Sbjct: 26   SMPLTEAPAFIL-----PPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFL 80

Query: 1856 MRSH-GPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
            +      T SLVIH V  ED+G Y C+A   S   ++ VE
Sbjct: 81   LDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 27/99 (27%), Positives = 44/99 (44%), Gaps = 4/99 (4%)

Query: 1640 VTEGDTATFECELS-QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTY 1698
            V EG    F C+++ +    VTW K    L PS R+ +      ++L++      D G Y
Sbjct: 172  VKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVY 231

Query: 1699 SCAV--GTARAG-PVRLTVRERTVAVLSELRSVSAREGD 1734
            +C V  G+ +A     L+++    A  S +R   A   D
Sbjct: 232  TCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD 270



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 22/77 (28%), Positives = 40/77 (51%), Gaps = 5/77 (6%)

Query: 1007 VVLMCELSRED-APVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC---- 1061
            ++L C++S +  A + W  +G  ++ ++ ++L ++G  C + +  A PED G + C    
Sbjct: 1115 LLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKN 1174

Query: 1062 DAGDDSAFFTVTVTAPP 1078
            DAG       VTV   P
Sbjct: 1175 DAGQAECSCQVTVDDAP 1191



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 24/126 (19%)

Query: 343  FTRPLQDVEGREHGIAVLECKVPNSRIP-TAWFREDQRLLPCRKYE-QIEEGTVRRLIIH 400
            F++ ++D+E  E   A  +CK+     P   WF++DQ +   R ++   +E     LII 
Sbjct: 1811 FSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIIS 1870

Query: 401  RLKADDDGIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGR 460
             +  DDD  Y C+    V ++   T                    A L+VET+E G EG 
Sbjct: 1871 DVCGDDDAKYTCK---AVNSLGEATC------------------TAELIVETMEEG-EGE 1908

Query: 461  WSRDGE 466
               + E
Sbjct: 1909 GEEEEE 1914



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 1/85 (1%)

Query: 9   GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAA-SERLSFPADGAEH 67
           G+ P F+  PR V    G    + C + G+P P V W + G+ L   +       +    
Sbjct: 718 GTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVF 777

Query: 68  GLLLTAALPTDAGVYVCRARNAAGE 92
            L+L    P  AG Y    +N  GE
Sbjct: 778 TLVLKKVQPWHAGQYEILLKNRVGE 802



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 18/69 (26%), Positives = 37/69 (53%), Gaps = 1/69 (1%)

Query: 817  VHAITSECVMLACEVDRED-APVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGG 875
            VH    + ++L C+V  +  A + W  +G+ ++ + F++L  EG    + +    P D G
Sbjct: 1107 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRG 1166

Query: 876  EFQCVAGDE 884
             ++CVA ++
Sbjct: 1167 LYKCVAKND 1175



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 34/112 (30%), Positives = 45/112 (40%), Gaps = 8/112 (7%)

Query: 128  PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
            P F    R   V+ G+     C+  G P+P + W KD  ++ E   S HF  Q    EDG
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRE---SRHF--QIDYDEDG 1863

Query: 188  PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE 239
               + +L I      D   Y C A N+ G A   A L V    E      +E
Sbjct: 1864 ---NCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEE 1912



 Score = 35.0 bits (79), Expect = 0.70
 Identities = 18/71 (25%), Positives = 38/71 (53%), Gaps = 1/71 (1%)

Query: 1090 DLHFGAPGRVELRCEVAP-AGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDA 1148
            D+H     ++ L+C+V+    + + W  +G  ++ +  + L  EG   ++++  A PED 
Sbjct: 1106 DVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR 1165

Query: 1149 GEYVCETRHEA 1159
            G Y C  +++A
Sbjct: 1166 GLYKCVAKNDA 1176



 Score = 32.7 bits (73), Expect = 3.5
 Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 5/62 (8%)

Query: 925 PWAEVRWTKDGEEVVESPALLLQKEDTVR---RLVLPAVQLEDSGEYLCEIDDESASFTV 981
           P  +V W ++G+ +      LL  +  +R    LV+ AV  ED G+Y CE  + S +  V
Sbjct: 60  PEPQVTWHRNGQPITSGGRFLL--DCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQV 117

Query: 982 TV 983
           TV
Sbjct: 118 TV 119



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 17/65 (26%), Positives = 29/65 (44%), Gaps = 1/65 (1%)

Query: 1637 DLEVTEGDTATFECELSQ-ALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDA 1695
            D+ V EG     +C++S    A + W  +G  L  +  + L   G+   + + +  P D 
Sbjct: 1106 DVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR 1165

Query: 1696 GTYSC 1700
            G Y C
Sbjct: 1166 GLYKC 1170



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 4/67 (5%)

Query: 1637 DLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRL--QALGTRRLLQLRRCGPS 1693
            DLEV EG  A F+C++      +V W KD  ++  S   ++     G   L+    CG  
Sbjct: 1817 DLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDD 1876

Query: 1694 DAGTYSC 1700
            DA  Y+C
Sbjct: 1877 DA-KYTC 1882


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,826,359
Number of Sequences: 37866
Number of extensions: 4585177
Number of successful extensions: 31556
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 282
Number of HSP's that attempted gapping in prelim test: 13543
Number of HSP's gapped (non-prelim): 8064
length of query: 1896
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1779
effective length of database: 13,817,196
effective search space: 24580791684
effective search space used: 24580791684
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.