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Search of human proteins with 109689695
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109689695 transient receptor potential cation channel,
subfamily M, member 8 [Homo sapiens]
(1104 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109689695 transient receptor potential cation channel, subfam... 2249 0.0
gi|4507689 transient receptor potential cation channel, subfamil... 838 0.0
gi|21314671 transient receptor potential cation channel, subfami... 576 e-164
gi|11225266 transient receptor potential cation channel, subfami... 571 e-162
gi|154091314 transient receptor potential cation channel, subfam... 322 2e-87
gi|154091318 transient receptor potential cation channel, subfam... 286 1e-76
gi|154091316 transient receptor potential cation channel, subfam... 283 6e-76
gi|154091320 transient receptor potential cation channel, subfam... 282 1e-75
gi|154091310 transient receptor potential cation channel, subfam... 276 1e-73
gi|154091312 transient receptor potential cation channel, subfam... 274 4e-73
gi|154091308 transient receptor potential cation channel, subfam... 272 1e-72
gi|94538366 transient receptor potential cation channel, subfami... 253 5e-67
gi|148612863 transient receptor potential cation channel, subfam... 240 6e-63
gi|18921093 transient receptor potential cation channel, subfami... 216 1e-55
gi|45935368 transient receptor potential cation channel, subfami... 151 4e-36
gi|55953096 transient receptor potential cation channel, subfami... 141 4e-33
gi|209863030 transient receptor potential cation channel, subfam... 109 2e-23
gi|209863026 transient receptor potential cation channel, subfam... 109 2e-23
gi|209863024 transient receptor potential cation channel, subfam... 109 2e-23
gi|7706747 transient receptor potential cation channel, subfamil... 109 2e-23
gi|6912736 transient receptor potential cation channel, subfamil... 102 3e-21
gi|209863028 transient receptor potential cation channel, subfam... 99 2e-20
gi|209863032 transient receptor potential cation channel, subfam... 95 4e-19
gi|194733735 transient receptor potential cation channel, subfam... 67 7e-11
gi|4507687 transient receptor potential cation channel, subfamil... 67 7e-11
gi|4507685 transient receptor potential cation channel, subfamil... 63 1e-09
gi|9966865 transient receptor potential cation channel, subfamil... 62 2e-09
gi|5730102 transient receptor potential cation channel, subfamil... 59 2e-08
gi|21735483 transient receptor potential cation channel, subfami... 52 4e-06
gi|22547184 transient receptor potential cation channel, subfami... 47 1e-04
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 2249 bits (5828), Expect = 0.0
Identities = 1104/1104 (100%), Positives = 1104/1104 (100%)
Query: 1 MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD 60
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD
Sbjct: 1 MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD 60
Query: 61 SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL 120
SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
Sbjct: 61 SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL 120
Query: 121 SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL 180
SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
Sbjct: 121 SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL 180
Query: 181 TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY 240
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY
Sbjct: 181 TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY 240
Query: 241 LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP 300
LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
Sbjct: 241 LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP 300
Query: 301 IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR 360
IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
Sbjct: 301 IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR 360
Query: 361 FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE 420
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE
Sbjct: 361 FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE 420
Query: 421 QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN 480
QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
Sbjct: 421 QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN 480
Query: 481 GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR 540
GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
Sbjct: 481 GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR 540
Query: 541 NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT 600
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
Sbjct: 541 NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT 600
Query: 601 LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA 660
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
Sbjct: 601 LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA 660
Query: 661 VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH 720
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
Sbjct: 661 VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH 720
Query: 721 KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC 780
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC
Sbjct: 721 KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC 780
Query: 781 DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT 840
DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
Sbjct: 781 DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT 840
Query: 841 LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF 900
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
Sbjct: 841 LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF 900
Query: 901 RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
Sbjct: 901 RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY
Sbjct: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH
Sbjct: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
Query: 1081 RFRQLDTKLNDLKGLLKEIANKIK 1104
RFRQLDTKLNDLKGLLKEIANKIK
Sbjct: 1081 RFRQLDTKLNDLKGLLKEIANKIK 1104
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 838 bits (2166), Expect = 0.0
Identities = 457/1084 (42%), Positives = 661/1084 (60%), Gaps = 63/1084 (5%)
Query: 38 ESDLVNFIQANFKKRECVFFTKDSKATEN---VCKCGYAQSQHMEGT---QINQSEKWNY 91
+ L ++I N KK+ECV+F + SK ++ VC+CGY QH+E Q +W+
Sbjct: 56 QESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDP 115
Query: 92 KKHTKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTG 150
KKH +E PTDAFGDI F L +K KY+R+S DT + ++Y L+TQHW L PNL+ISVTG
Sbjct: 116 KKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTG 175
Query: 151 GAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEEN- 208
GAKNF +KPR++ IF R L+ +AQ+ GAWI+TGG+H G+MK +GE VRD ++S S +E
Sbjct: 176 GAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGE 235
Query: 209 IVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCH 268
++ IG+A WG V R+ LI G F A+Y++D+ + L LD+NH+H +LVD+G H
Sbjct: 236 LITIGVATWGTVHRREGLIH---PTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTH 292
Query: 269 GHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVV 328
G VE LR +LEK+ISE+T + KIPIVC GG TL I+ + N PCVV
Sbjct: 293 GQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVV 352
Query: 329 VEGSGQIADVIASLVEVEDA-LTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILEC 387
VEGSG++ADVIA + + + +T S +++KL F E W K +++I+
Sbjct: 353 VEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRR 412
Query: 388 SHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQ-DKDNWNGQLKLLLEWNQLDLANDEI 446
LLTV + + G + V AI AL KA + + +NW+ QLKL + WN++D+A EI
Sbjct: 413 RQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEI 472
Query: 447 FTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSN-HFSTLV 505
F ++ +W+ +DL M ALI ++P+FV+LFLENG+ L++F+T D L L+ N S L
Sbjct: 473 FMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLF 532
Query: 506 YRNLQ--------------IAKNSYNDALLTFVWKLVANFRRGFRKEDRNGR-------- 543
+ LQ A + + +L+ +F + R+
Sbjct: 533 HSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPV 592
Query: 544 DEMDIELHDVS------------PITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAA 591
+ + + VS T P++ L IWAI+QN++EL+ +IW Q++ C AA
Sbjct: 593 PHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAA 652
Query: 592 LGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAW 651
L SK+LK L+K + D +++ E LA EYE RA+ +FTECY DE+ A++LL EAW
Sbjct: 653 LACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAW 712
Query: 652 GGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVS 711
G + CL+LA+EA D F++ G+Q FL+K W+G++S D W++ LC+ PL+ G +S
Sbjct: 713 GKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLIS 772
Query: 712 FRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVL 771
FR+K + AFFT+P VVF N++ Y AFL LFAYVL++DF VP E +
Sbjct: 773 FREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAI 832
Query: 772 YSLVFVLFCDEVRQWYVN---------GVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNK 822
Y +F L C+E+RQ + + YF+D WN +D + F+AG+ RL
Sbjct: 833 YLWLFSLVCEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL---IP 889
Query: 823 SSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFG 882
++LY GRVI LD+I+F LRL+HIFT+S+ LGPKII+++RM+ DVFFFLFL AVW+V+FG
Sbjct: 890 ATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFG 949
Query: 883 VARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNES-KPLCV 941
VA+Q IL NE+R W+FR +Y YL +FGQ+P +DG ++ HC+ G + KP C
Sbjct: 950 VAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCP 1009
Query: 942 ELD-EHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYF 1000
E D P FPEW+T+ L+C+Y+L TNILL+NLL+AMF YT VQE+ DQ+WKFQR+
Sbjct: 1010 ESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHD 1069
Query: 1001 LVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMK 1060
L++EY R P PFI+ ++ + +K+ +++ + KNE+ L+WE +K
Sbjct: 1070 LIEEYHGRPAAPPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLK 1129
Query: 1061 ENYL 1064
ENYL
Sbjct: 1130 ENYL 1133
>gi|21314671 transient receptor potential cation channel, subfamily M,
member 4 [Homo sapiens]
Length = 1214
Score = 576 bits (1484), Expect = e-164
Identities = 382/1185 (32%), Positives = 609/1185 (51%), Gaps = 143/1185 (12%)
Query: 43 NFIQANFKKRECVFFTKDSKATEN-VCKCGYAQSQH----ME---GTQINQSEKWNYKKH 94
++I FKK+ C F DS +C+CG ++ H ME G + W+ H
Sbjct: 9 SWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAV--VTVWDSDAH 66
Query: 95 TKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAK 153
T E PTDA+G++ F G+K ++RLS TD +Y L+T+ W + PNLV+SV GG+
Sbjct: 67 TTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSG 126
Query: 154 NFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAI 212
L+ ++ + R L+ AQS GAWI+TGG H G+ +++G VRD+ ++ + +VA+
Sbjct: 127 GPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAM 186
Query: 213 GIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPL-YILDNNHTHLLLVDNGCHGHP 271
G+A WG+V NRDTLI + +G F A+Y D + + LD N++ LVD+G HG
Sbjct: 187 GVAPWGVVRNRDTLI---NPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCL 243
Query: 272 TVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEG 331
E + R +LE YIS++ G IP++ G ++ L I + + ++PC++V G
Sbjct: 244 GGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAG 303
Query: 332 SGQIADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLL 391
SG AD +A +E A S ++ R R P+ + E ++ I+ LL
Sbjct: 304 SGGAADCLAETLEDTLAPGSGGARQGEAR--DRIRRFFPKGDLEVLQAQVERIMTRKELL 361
Query: 392 TVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDR 451
TV E+ +E + + AL KA +SE + +L+L + WN++D+A E+F D
Sbjct: 362 TVYSSEDGSEEFETIVLK-ALVKACGSSEASA--YLDELRLAVAWNRVDIAQSELFRGDI 418
Query: 452 RWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNL-- 509
+W S L+ + AL+ DRP+FVRL + +GL+L FLT L +L+S S + RNL
Sbjct: 419 QWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLD 478
Query: 510 ------------------QIAKNSYNDALLTFVWKLVA-----------NFRRGFRKEDR 540
++ L + K+ A + +GF +
Sbjct: 479 QASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMY 538
Query: 541 NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT 600
D+ L + + + P L +WA+L N+ +++ WE +ALGA LL+
Sbjct: 539 LLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRV 598
Query: 601 LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA 660
+A+++ D A ++LA ++E V+LF ECY S E A +LL+ C WG + CL+LA
Sbjct: 599 MARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLA 658
Query: 661 VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKK----- 715
++A + F AQ GVQ+ L+++W+G+++ T W ++L F PL+ ++FRK
Sbjct: 659 MQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPT 718
Query: 716 ----------------------PVDK--------------------HKKLLWYYVAFFTS 733
P +K ++ L + F+ +
Sbjct: 719 REELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGA 778
Query: 734 PFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPP---ELVLYSLVFVLFCDEVRQWYVNG 790
P +F NVV Y+ FLLLF+ VLL+DF P PP EL+LY F L C+E+RQ G
Sbjct: 779 PVTIFMGNVVSYLLFLLLFSRVLLVDFQ--PAPPGSLELLLYFWAFTLLCEELRQGLSGG 836
Query: 791 VN--------------------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRV 830
Y D WN D + L F+ G+ RL + GR
Sbjct: 837 GGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL---TPGLYHLGRT 893
Query: 831 IFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILR 890
+ C+D+++FT+RL+HIFTV++ LGPKI+++ +M+ DVFFFLF VW+VA+GVA +G+LR
Sbjct: 894 VLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLR 953
Query: 891 QNEQRWRWIFRSVIYEPYLAMFGQVP-SDVDGTTYDFAHCTF-TGNESKPLCVELDEHNL 948
+ + I R V Y PYL +FGQ+P D+D + ++C+ G + P + +
Sbjct: 954 PRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGT-CV 1012
Query: 949 PRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR 1008
++ W+ + L+ I++L NILLVNLL+AMF YT G VQ N+D WK QRY L++E+ SR
Sbjct: 1013 SQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSR 1072
Query: 1009 LNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESS--------VCCFKNEDNETLAWEGVMK 1060
+ PFIV ++ ++++ + C + ++ + S V K + + L WE V K
Sbjct: 1073 PALAPPFIVISHLRLLLR---QLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHK 1129
Query: 1061 ENYLV-KINTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKIK 1104
EN+L+ + K SE ++ +++D L L G ++E ++K
Sbjct: 1130 ENFLLARARDKRESDSERLKRTSQKVDLALKQL-GHIREYEQRLK 1173
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 571 bits (1472), Expect = e-162
Identities = 375/1104 (33%), Positives = 578/1104 (52%), Gaps = 129/1104 (11%)
Query: 104 GDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMR 162
G++ F GKK GK++R+ +L++LL WHL PNLV+S+ G + FA+K +R
Sbjct: 26 GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85
Query: 163 KIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTI-SRSSEENIVAIGIAAWGMV 220
+ + L+ AQS GAWILT GL +++G+ VRD+++ S S++ +VA+G+A+ G V
Sbjct: 86 DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145
Query: 221 SNRDTLIRNCDAEGYFLAQYLMDDF-TRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRN 279
+R L +A+ F Y DD ++ PL LD+N +H +LV+ G G +LR
Sbjct: 146 LHRRILE---EAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRL 202
Query: 280 QLEKYISERTIQDSNYGG----KIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQI 335
+LEK+ISE Q + YGG +IP++C G TL+ I+ +++ P +++ GSG I
Sbjct: 203 RLEKHISE---QRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGI 259
Query: 336 ADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIK 395
ADV+A+LV L +++ P E+ W K L+ I HLLTV
Sbjct: 260 ADVLAALVNQPHLLVPKVAEKQFKEKFPS--KHFSWEDIVRWTKLLQNITSHQHLLTVYD 317
Query: 396 MEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWES 455
E+ G E + I AL KA + Q+ ++ +LKL + W+++D+A EIF D W+S
Sbjct: 318 FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377
Query: 456 ADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELF-SNHFSTLVYRNLQIAKN 514
DL+EVM AL+ ++P+FVRLF++NG ++ FLT+ L EL+ S +L++ LQ
Sbjct: 378 CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQ---R 434
Query: 515 SYNDALLTF----------------------VWKLVANFR----RGFRKEDRNGRDEMDI 548
+A LT V +++ +F RGF ++ R G D
Sbjct: 435 KQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPG-DRRRA 493
Query: 549 E------------LHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASK 596
E L D++ + +P + LF+WA+LQN+ E++ W + AAL A K
Sbjct: 494 EKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACK 553
Query: 597 LLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNC 656
+LK ++ ++ + AA + E +YE A++LF+ECYS+ E A LLV W + C
Sbjct: 554 ILKEMSHLETEAEAARATREA--KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTC 611
Query: 657 LELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKK- 715
L LA EA + F A GVQ FL++ W+G+++ T +++ LV ++F ++
Sbjct: 612 LHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEA 671
Query: 716 -------------PVDKHKK----------------------------LLWYYVAFFTSP 734
+D K LL + F+ +P
Sbjct: 672 PLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAP 731
Query: 735 FVVFSWNVVFYIAFLLLFAYVLLMDFHSVPH---PPELVLYSLVFVLFCDEVRQWYVNGV 791
VF NVV Y AFL LF YVLL+DF P PE+ LY VF L +E+RQ +
Sbjct: 732 VTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDE 791
Query: 792 N---------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLR 842
+ Y D WN D + +F FI G+ R+ S+ +GR + +D+++FTLR
Sbjct: 792 DTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRM---LPSAFEAGRTVLAMDFMVFTLR 848
Query: 843 LIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRS 902
LIHIF + + LGPKII+++RM+ DVFFFLF +VW+VA+GV Q +L ++ R WIFR
Sbjct: 849 LIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRR 908
Query: 903 VIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPR-FPEWITIPLV 960
V+Y PYL +FGQ+P D +D +C+ + PL +E D + P + W+ I L+
Sbjct: 909 VLYRPYLQIFGQIPLDEIDEAR---VNCS-----THPLLLE-DSPSCPSLYANWLVILLL 959
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
++L TN+LL+NLL+AMF YT VQ N D WKFQRY L+ EY R + PFI+ ++
Sbjct: 960 VTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSH 1019
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
+ +++ FK + K D + + WE V KEN+L K+ + D+ E+
Sbjct: 1020 LSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLR 1079
Query: 1081 RFRQLDTKLNDLKGLLKEIANKIK 1104
+ + G L+E +IK
Sbjct: 1080 KTAHRVDFIAKYLGGLREQEKRIK 1103
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 322 bits (824), Expect = 2e-87
Identities = 226/741 (30%), Positives = 363/741 (48%), Gaps = 96/741 (12%)
Query: 43 NFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQIN-----------------Q 85
++I+ F KRECV +K C CG QH+ T Q
Sbjct: 63 SWIERAFYKRECVHIIPSTKDPHRCC-CGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQ 121
Query: 86 SEKWNYKKHTKEFPTDAFGDIQFETLGKKGK--YIRLSCDTDAEILYELLTQHWHLKTPN 143
SEKW+ KHT+ PTDAFG I+F+ G K Y+R+S DT ++L L+T+ W L+ P
Sbjct: 122 SEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPK 181
Query: 144 LVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTIS 202
L+ISV GG +NF L+P+++++F + LI A + GAWI TGG + G+++++G+ ++D+ +
Sbjct: 182 LLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDH--A 239
Query: 203 RSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLL 262
S I IGIA WG+V N++ LI Y M T +L++ H+H +L
Sbjct: 240 SKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLT-----VLNSMHSHFIL 294
Query: 263 VDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKN 322
DNG G E KLR QLEK+IS + I ++ G +P+V GG + + +++
Sbjct: 295 ADNGTTGKYGAEVKLRRQLEKHISLQKI-NTRIGQGVPVVALIVEGGPNVISIVLEYLRD 353
Query: 323 K--IPCVVVEGSGQIADVIA--SLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWI 378
+P VV +GSG+ +D++A E L + +++++L+ + +T + + +I
Sbjct: 354 TPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFI 413
Query: 379 KWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQ 438
L E ++ L+TV +M G + + AI AL K + S D QL L L WN+
Sbjct: 414 I-LMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPD------QLSLALAWNR 466
Query: 439 LDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFS 498
+D+A +IF ++W L++ M AL+ DR FV+L +ENG+++ +FLT L EL++
Sbjct: 467 VDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYN 526
Query: 499 NHF--STLVYRNLQIAKN---------SYNDALLTFVWKLVANFR--------------- 532
S +Y ++ K S D L + + +R
Sbjct: 527 TRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNL 586
Query: 533 --------------------RGFRKEDRNGRDEMDIELHDVSPITRH---PLQALFIWAI 569
R RK + +E+DI+L D P H P L +WA+
Sbjct: 587 FGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDD--PEINHFPFPFHELMVWAV 644
Query: 570 LQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGE-SEEL---ANEYETRA 625
L +++++ W+ AL A KL K +A ++ + + S+EL + ++ A
Sbjct: 645 LMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLA 704
Query: 626 VELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGE 685
VEL + Y DE LA +LL Y + W + CL+LAV A + FIA Q L+ W G
Sbjct: 705 VELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGR 764
Query: 686 I-SRDTKNWKIILCLFIIPLV 705
+ R K+IL + + P +
Sbjct: 765 LRMRKNSGLKVILGILLPPSI 785
Score = 172 bits (435), Expect = 2e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 865 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 924
Query: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 925 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 982
Query: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 983 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 1042
Query: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 1043 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 1093
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 1094 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1153
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 1154 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1202
Query: 1081 RFRQLDTKLN 1090
FR+ D + N
Sbjct: 1203 -FREKDDRFN 1211
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 286 bits (731), Expect = 1e-76
Identities = 194/638 (30%), Positives = 322/638 (50%), Gaps = 66/638 (10%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY 295
M T +L++ H+H +L DNG G E KLR QLEK+IS + I ++
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKI-NTRI 173
Query: 296 GGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVVEGSGQIADVIA--SLVEVEDALTS 351
G +P+V GG + + +++ +P VV +GSG+ +D++A E L +
Sbjct: 174 GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLIN 233
Query: 352 SAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYA 411
+++++L+ + +T + + +I L E ++ L+TV +M G + + AI A
Sbjct: 234 ESLRDQLLVTIQKTFTYTRTQAQHLFII-LMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 412 LYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRP 471
L K + S D QL L L WN++D+A +IF ++W L++ M AL+ DR
Sbjct: 293 LLKGANASAPD------QLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRV 346
Query: 472 KFVRLFLENGLNLRKFLTHDVLTELFSNHF--STLVYRNLQIAKN---------SYNDAL 520
FV+L +ENG+++ +FLT L EL++ S +Y ++ K S D
Sbjct: 347 DFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIG 406
Query: 521 LTFVWKLVANFR-------------------------RGFRKEDRNGRDEMDIELHDVSP 555
L + + +R R RK + +E+DI+L D P
Sbjct: 407 LVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTKKREEEVDIDLDD--P 464
Query: 556 ITRH---PLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAG 612
H P L +WA+L +++++ W+ AL A KL K +A ++ +
Sbjct: 465 EINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVD 524
Query: 613 E-SEEL---ANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHF 668
+ S+EL + ++ AVEL + Y DE LA +LL Y + W + CL+LAV A + F
Sbjct: 525 DISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDF 584
Query: 669 IAQPGVQNFLSKQWYGEI-SRDTKNWKIILCLFIIPLV 705
IA Q L+ W G + R K+IL + + P +
Sbjct: 585 IAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSI 622
Score = 172 bits (435), Expect = 2e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 702 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 761
Query: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 762 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 819
Query: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 820 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 879
Query: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 880 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 930
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 931 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 990
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 991 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1039
Query: 1081 RFRQLDTKLN 1090
FR+ D + N
Sbjct: 1040 -FREKDDRFN 1048
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 283 bits (724), Expect = 6e-76
Identities = 194/650 (29%), Positives = 322/650 (49%), Gaps = 78/650 (12%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY 295
M T +L++ H+H +L DNG G E KLR QLEK+IS + I ++
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKI-NTRI 173
Query: 296 GGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVVEGSGQIADVIA--SLVEVEDALTS 351
G +P+V GG + + +++ +P VV +GSG+ +D++A E L +
Sbjct: 174 GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLIN 233
Query: 352 SAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYA 411
+++++L+ + +T + + +I L E ++ L+TV +M G + + AI A
Sbjct: 234 ESLRDQLLVTIQKTFTYTRTQAQHLFII-LMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 412 LYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRP 471
L K + S D QL L L WN++D+A +IF ++W L++ M AL+ DR
Sbjct: 293 LLKGANASAPD------QLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRV 346
Query: 472 KFVRLFLENGLNLRKFLTHDVLTELFSNHF---STLVYRNLQIAKNSY-NDALLTFVWKL 527
FV+L +ENG+++ +FLT L EL++ +TL + + K Y + F L
Sbjct: 347 DFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNL 406
Query: 528 VANFR--------------------------------------------RGFRKEDRNGR 543
++R R RK +
Sbjct: 407 PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTKKRE 466
Query: 544 DEMDIELHDVSPITRH---PLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT 600
+E+DI+L D P H P L +WA+L +++++ W+ AL A KL K
Sbjct: 467 EEVDIDLDD--PEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKA 524
Query: 601 LAKVKNDINAAGE-SEEL---ANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNC 656
+A ++ + + S+EL + ++ AVEL + Y DE LA +LL Y + W + C
Sbjct: 525 MAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATC 584
Query: 657 LELAVEATDQHFIAQPGVQNFLSKQWYGEI-SRDTKNWKIILCLFIIPLV 705
L+LAV A + FIA Q L+ W G + R K+IL + + P +
Sbjct: 585 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSI 634
Score = 172 bits (435), Expect = 2e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 714 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 773
Query: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 774 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 831
Query: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 832 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 891
Query: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 892 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 942
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 943 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1002
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 1003 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1051
Query: 1081 RFRQLDTKLN 1090
FR+ D + N
Sbjct: 1052 -FREKDDRFN 1060
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 282 bits (721), Expect = 1e-75
Identities = 194/648 (29%), Positives = 322/648 (49%), Gaps = 76/648 (11%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY 295
M T +L++ H+H +L DNG G E KLR QLEK+IS + I ++
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKI-NTRI 173
Query: 296 GGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVVEGSGQIADVIA--SLVEVEDALTS 351
G +P+V GG + + +++ +P VV +GSG+ +D++A E L +
Sbjct: 174 GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLIN 233
Query: 352 SAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYA 411
+++++L+ + +T + + +I L E ++ L+TV +M G + + AI A
Sbjct: 234 ESLRDQLLVTIQKTFTYTRTQAQHLFII-LMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 412 LYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRP 471
L K + S D QL L L WN++D+A +IF ++W L++ M AL+ DR
Sbjct: 293 LLKGANASAPD------QLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRV 346
Query: 472 KFVRLFLENGLNLRKFLTHDVLTELFSNHF--STLVYRNLQIAKN---------SYNDAL 520
FV+L +ENG+++ +FLT L EL++ S +Y ++ K S D
Sbjct: 347 DFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIG 406
Query: 521 LTFVWKLVANFR-----------------------------------RGFRKEDRNGRDE 545
L + + +R R RK + +E
Sbjct: 407 LVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEE 466
Query: 546 MDIELHDVSPITRH---PLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLA 602
+DI+L D P H P L +WA+L +++++ W+ AL A KL K +A
Sbjct: 467 VDIDLDD--PEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMA 524
Query: 603 KVKNDINAAGE-SEEL---ANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLE 658
++ + + S+EL + ++ AVEL + Y DE LA +LL Y + W + CL+
Sbjct: 525 HEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQ 584
Query: 659 LAVEATDQHFIAQPGVQNFLSKQWYGEI-SRDTKNWKIILCLFIIPLV 705
LAV A + FIA Q L+ W G + R K+IL + + P +
Sbjct: 585 LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSI 632
Score = 172 bits (435), Expect = 2e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 712 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 771
Query: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 772 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 829
Query: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 830 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 889
Query: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 890 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 940
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 941 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1000
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 1001 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1049
Query: 1081 RFRQLDTKLN 1090
FR+ D + N
Sbjct: 1050 -FREKDDRFN 1058
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 276 bits (705), Expect = 1e-73
Identities = 196/662 (29%), Positives = 322/662 (48%), Gaps = 89/662 (13%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQ---- 291
M T +L++ H+H +L DNG G E KLR QLEK+IS + I
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCL 174
Query: 292 -------------------DS-NYGGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVV 329
DS G +P+V GG + + +++ +P VV
Sbjct: 175 PFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVC 234
Query: 330 EGSGQIADVIA--SLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILEC 387
+GSG+ +D++A E L + +++++L+ + +T + + +I L E ++
Sbjct: 235 DGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFII-LMECMKK 293
Query: 388 SHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIF 447
L+TV +M G + + AI AL K + S D QL L L WN++D+A +IF
Sbjct: 294 KELITVFRMGSEGHQDIDLAILTALLKGANASAPD------QLSLALAWNRVDIARSQIF 347
Query: 448 TNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHF--STLV 505
++W L++ M AL+ DR FV+L +ENG+++ +FLT L EL++ S +
Sbjct: 348 IYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTL 407
Query: 506 YRNLQIAKN---------SYNDALLTFVWKLVANFR------------------------ 532
Y ++ K S D L + + +R
Sbjct: 408 YHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIP 467
Query: 533 -RGFRKEDRNGRDEMDIELHDVSPITRH---PLQALFIWAILQNKKELSKVIWEQTRGCT 588
R RK + +E+DI+L D P H P L +WA+L +++++ W+
Sbjct: 468 LRRGRKTTKKREEEVDIDLDD--PEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAM 525
Query: 589 LAALGASKLLKTLAKVKNDINAAGE-SEEL---ANEYETRAVELFTECYSSDEDLAEQLL 644
AL A KL K +A ++ + + S+EL + ++ AVEL + Y DE LA +LL
Sbjct: 526 AKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLL 585
Query: 645 VYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEI-SRDTKNWKIILCLFIIP 703
Y + W + CL+LAV A + FIA Q L+ W G + R K+IL + + P
Sbjct: 586 TYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPP 645
Query: 704 LV 705
+
Sbjct: 646 SI 647
Score = 172 bits (435), Expect = 2e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 727 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 786
Query: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 787 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 844
Query: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 845 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 904
Query: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 905 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 955
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 956 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1015
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 1016 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1064
Query: 1081 RFRQLDTKLN 1090
FR+ D + N
Sbjct: 1065 -FREKDDRFN 1073
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 274 bits (700), Expect = 4e-73
Identities = 192/658 (29%), Positives = 322/658 (48%), Gaps = 84/658 (12%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY 295
M T +L++ H+H +L DNG G E KLR QLEK+IS + I ++
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKI-NTRI 173
Query: 296 GGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVVEGSGQIADVIA--SLVEVEDALTS 351
G +P+V GG + + +++ +P VV +GSG+ +D++A E L +
Sbjct: 174 GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLIN 233
Query: 352 SAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYA 411
+++++L+ + +T + + +I L E ++ L+TV +M G + + AI A
Sbjct: 234 ESLRDQLLVTIQKTFTYTRTQAQHLFII-LMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 412 LYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRP 471
L K + S D QL L L WN++D+A +IF ++W L++ M AL+ DR
Sbjct: 293 LLKGANASAPD------QLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRV 346
Query: 472 KFVRLFLENGLNLRKFLTHDVLTELFSNHF---STLVYRNLQIAKNSYN----------- 517
FV+L +ENG+++ +FLT L EL++ +TL + + K Y
Sbjct: 347 DFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNL 406
Query: 518 ---------DALLTFVWKLVANFRRGFRK------------------------ED----R 540
D L + + +R + + ED R
Sbjct: 407 PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLR 466
Query: 541 NGRD-----EMDIELHDVSPITRH---PLQALFIWAILQNKKELSKVIWEQTRGCTLAAL 592
GR E ++++ P H P L +WA+L +++++ W+ AL
Sbjct: 467 RGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKAL 526
Query: 593 GASKLLKTLAKVKNDINAAGE-SEEL---ANEYETRAVELFTECYSSDEDLAEQLLVYSC 648
A KL K +A ++ + + S+EL + ++ AVEL + Y DE LA +LL Y
Sbjct: 527 VACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYEL 586
Query: 649 EAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEI-SRDTKNWKIILCLFIIPLV 705
+ W + CL+LAV A + FIA Q L+ W G + R K+IL + + P +
Sbjct: 587 KNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSI 644
Score = 172 bits (435), Expect = 2e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 724 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 783
Query: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 784 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 841
Query: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 842 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 901
Query: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 902 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 952
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 953 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1012
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 1013 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1061
Query: 1081 RFRQLDTKLN 1090
FR+ D + N
Sbjct: 1062 -FREKDDRFN 1070
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 272 bits (695), Expect = 1e-72
Identities = 196/672 (29%), Positives = 322/672 (47%), Gaps = 99/672 (14%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQ---- 291
M T +L++ H+H +L DNG G E KLR QLEK+IS + I
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCL 174
Query: 292 -------------------DS-NYGGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVV 329
DS G +P+V GG + + +++ +P VV
Sbjct: 175 PFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVC 234
Query: 330 EGSGQIADVIA--SLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILEC 387
+GSG+ +D++A E L + +++++L+ + +T + + +I L E ++
Sbjct: 235 DGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFII-LMECMKK 293
Query: 388 SHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIF 447
L+TV +M G + + AI AL K + S D QL L L WN++D+A +IF
Sbjct: 294 KELITVFRMGSEGHQDIDLAILTALLKGANASAPD------QLSLALAWNRVDIARSQIF 347
Query: 448 TNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHF--STLV 505
++W L++ M AL+ DR FV+L +ENG+++ +FLT L EL++ S +
Sbjct: 348 IYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTL 407
Query: 506 YRNLQIAKN---------SYNDALLTFVWKLVANFR------------------------ 532
Y ++ K S D L + + +R
Sbjct: 408 YHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKAL 467
Query: 533 -----------RGFRKEDRNGRDEMDIELHDVSPITRH---PLQALFIWAILQNKKELSK 578
R RK + +E+DI+L D P H P L +WA+L +++++
Sbjct: 468 KLLGMEDDIPLRRGRKTTKKREEEVDIDLDD--PEINHFPFPFHELMVWAVLMKRQKMAL 525
Query: 579 VIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGE-SEEL---ANEYETRAVELFTECYS 634
W+ AL A KL K +A ++ + + S+EL + ++ AVEL + Y
Sbjct: 526 FFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYK 585
Query: 635 SDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEI-SRDTKNW 693
DE LA +LL Y + W + CL+LAV A + FIA Q L+ W G + R
Sbjct: 586 QDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL 645
Query: 694 KIILCLFIIPLV 705
K+IL + + P +
Sbjct: 646 KVILGILLPPSI 657
Score = 172 bits (435), Expect = 2e-42
Identities = 109/370 (29%), Positives = 193/370 (52%), Gaps = 32/370 (8%)
Query: 730 FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVN 789
F+ +P V F + + YI +L+LF Y++L+ P E ++ S +F L +++R+ ++
Sbjct: 737 FYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMS 796
Query: 790 GVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTL 841
+ + WNV D + + F G++ RL S GRVI+C++ I + +
Sbjct: 797 EPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRS--DGRVIYCVNIIYWYI 854
Query: 842 RLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFR 901
RL+ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL NE+ + +
Sbjct: 855 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 914
Query: 902 SVIYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV 960
++ Y PY ++G+V +D +D C ++L + WI ++
Sbjct: 915 NIFYMPYWMIYGEVFADQID------PPCGQNETREDGKIIQLPP---CKTGAWIVPAIM 965
Query: 961 CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY 1020
Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ + R +P P I+F++
Sbjct: 966 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1025
Query: 1021 FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH 1080
M+ + CC+ + ES + D + + ++ L K++ EE
Sbjct: 1026 MTMIFQ---HLCCRWRKHES------DPDERDYGLKLFITDDELKKVHDFEEQCIEEY-- 1074
Query: 1081 RFRQLDTKLN 1090
FR+ D + N
Sbjct: 1075 -FREKDDRFN 1083
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 253 bits (647), Expect = 5e-67
Identities = 190/690 (27%), Positives = 331/690 (47%), Gaps = 120/690 (17%)
Query: 453 WESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHF---STLVYRNL 509
W +A L++ M AL+ DR FV+L +ENG+N++ FLT L EL++ +TL
Sbjct: 457 WVNA-LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVR 515
Query: 510 QIAKNS----YNDALLTFVWKLV-------------ANFR-------------------- 532
+ K++ Y+ +L+ L NFR
Sbjct: 516 DVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGM 575
Query: 533 -------RGFRKEDRNGRDEMDIELHDVSPIT-RHPLQALFIWAILQNKKELSKVIWEQT 584
+G +K+ + +E+DI++ D + ++P L +WA+L +++++ +W++
Sbjct: 576 EDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRG 635
Query: 585 RGCTLAALGASKLLKTLAKVKNDINAAGE-SEELAN---EYETRAVELFTECYSSDEDLA 640
AL A KL K +A ++ + + S++L N ++ A+EL + Y DE +A
Sbjct: 636 EESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIA 695
Query: 641 EQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEIS-RDTKNWKIILCL 699
+LL Y + W S CL+LAV A + FIA Q L+ W G + R K+I+ +
Sbjct: 696 MKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGI 755
Query: 700 FIIPLVGCGFVSFR----------KKPVD------------------------KHKKLLW 725
+ P + F+ FR K+ D +HKK
Sbjct: 756 LLPPTIL--FLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRS 813
Query: 726 YYVA-----FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC 780
+ F+ +P V F + + Y+ +LLLF YV+L+ P E ++ S + L
Sbjct: 814 IPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLAL 873
Query: 781 DEVRQWYVNGVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIF 832
+++R+ ++ + + WN+ D + + F+ G + RL N+ + GRVI+
Sbjct: 874 EKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQ--NQPYMGYGRVIY 931
Query: 833 CLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQN 892
C+D I + +R++ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL
Sbjct: 932 CVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPE 991
Query: 893 EQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVE-LDEHNLPRF 951
E+ + R++ Y PY ++G+V +D E P C E L + R
Sbjct: 992 EKPSWKLARNIFYMPYWMIYGEVFAD---------QIDLYAMEINPPCGENLYDEEGKRL 1042
Query: 952 P-----EWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYC 1006
P W+T L+ Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ +
Sbjct: 1043 PPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFH 1102
Query: 1007 SRLNIPFPFIVFAYFYMVVKKCFKCCCKEK 1036
R +P P I+ ++ Y+++ + C K++
Sbjct: 1103 DRPVLPPPMIILSHIYIIIMRLSGRCRKKR 1132
Score = 211 bits (537), Expect = 3e-54
Identities = 131/409 (32%), Positives = 223/409 (54%), Gaps = 36/409 (8%)
Query: 66 NVCKCGYAQSQHM-------------EGTQIN-QSEKWNYKKHTKEFPTDAFGDIQFETL 111
N C CG +QH+ E Q+ Q EKW+ KHT+ +PTD++G ++F+
Sbjct: 5 NRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGG 64
Query: 112 G--KKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-L 168
G K YIR+S DT + L L+ + W L+ P L+ISV GG +NF ++P+++++F + L
Sbjct: 65 GYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGL 124
Query: 169 IYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIR 228
I A + GAWI TGG G++ ++G+ ++D+ S S + AIGIA WG+V N++ L+
Sbjct: 125 IKAAMTTGAWIFTGGVSTGVISHVGDALKDH--SSKSRGRVCAIGIAPWGIVENKEDLVG 182
Query: 229 NCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISER 288
Y Q + + ++ L +L+N+HTH +L DNG G E KLR LEK+IS +
Sbjct: 183 KDVTRVY---QTMSNPLSK--LSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQ 237
Query: 289 TIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVVEGSGQIADVIASLVEV- 345
I ++ G +P+V GG + + ++ + IP V+ +GSG+ +D+++ +
Sbjct: 238 KI-NTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYC 296
Query: 346 -EDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIV 404
E + + +++E+L+ + +T + + ++ + E ++ L+TV +M G + +
Sbjct: 297 EEGGIINESLREQLLVTIQKTFN-YNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDI 355
Query: 405 SNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRW 453
AI AL K + S D QL L L WN++D+A +IF W
Sbjct: 356 EMAILTALLKGTNVSAPD------QLSLALAWNRVDIARSQIFVFGPHW 398
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 240 bits (612), Expect = 6e-63
Identities = 158/490 (32%), Positives = 262/490 (53%), Gaps = 49/490 (10%)
Query: 43 NFIQANFKKRECVFFTKDSKATENV------------CKCGYAQSQHM------------ 78
++I++ KRECV+ SK C CG QH
Sbjct: 5 SWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSD 64
Query: 79 --EGTQINQS-EKWNYKKHTKEFPTDAFGDIQFE--TLGKKGKYIRLSCDTDAEILYELL 133
G NQ+ E+W+ +KHT++ PTDA+G I F+ + + KY+RLS DT E++ +LL
Sbjct: 65 VKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLL 124
Query: 134 TQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYI 192
+ W ++ P LVISV GG + F L PR++++ + LI A + GAWILTGG + G+ K++
Sbjct: 125 LKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHV 184
Query: 193 GEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYI 252
G+ ++++ SRSS + I IGIA WG++ NR+ L+ Y Q L++ ++ L +
Sbjct: 185 GDALKEHA-SRSSRK-ICTIGIAPWGVIENRNDLVGRDVVAPY---QTLLNPLSK--LNV 237
Query: 253 LDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKET 312
L+N H+H +LVD+G G E +LR +LEK I+++ I + G +P+V GG
Sbjct: 238 LNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIH-ARIGQGVPVVALIFEGGPNV 296
Query: 313 LKAINTSIKNK--IPCVVVEGSGQIADVIASLVEV--EDALTSSAVKEKLVRFLPRTVSR 368
+ + ++ +P VV EG+G+ AD++A + + E A + ++ + +T +
Sbjct: 297 ILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFN- 355
Query: 369 LPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNG 428
+ E + L E ++ L+TV + + + AI AL K + S D
Sbjct: 356 FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFD------ 409
Query: 429 QLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFL 488
QL L L W+++D+A + +F ++W L++ M AL+ DR FV+L +ENG+++ KFL
Sbjct: 410 QLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFL 469
Query: 489 THDVLTELFS 498
T L EL++
Sbjct: 470 TIPRLEELYN 479
Score = 147 bits (372), Expect = 4e-35
Identities = 98/400 (24%), Positives = 198/400 (49%), Gaps = 49/400 (12%)
Query: 727 YVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQW 786
+ AF+ +P V F +N + Y+ FL+L+ +V+L+ +P E ++ + +F ++VR+
Sbjct: 845 FYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREI 904
Query: 787 YVNGVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSS-NKSSLY------SGRVI 831
+++ +F+D +N+ DT+ + F G R + N ++ Y +GR+I
Sbjct: 905 FMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLI 964
Query: 832 FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQ 891
+CL+ I + +RL+ V++ GP ++M+ +M+ ++F+ + + A+ +++FGV R+ IL
Sbjct: 965 YCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP 1024
Query: 892 NEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRF 951
+E + + +++ PY +FG+V Y+ C ++ +P+
Sbjct: 1025 HEAPSWTLAKDIVFHPYWMIFGEV------YAYEIDVCA-------------NDSVIPQI 1065
Query: 952 ---PEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR 1008
W+T L +Y+ I++VNLL+A F V+ ++ VWK+QRY + Y +
Sbjct: 1066 CGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK 1125
Query: 1009 LNIPFPFIVFAYFYMVVKKCFKCCC----KEKNMESSVCCFKNEDNETL-AWEGVMKENY 1063
+P P I+ ++ + F C C K+K + ED + L +E E Y
Sbjct: 1126 PVLPPPLIILSH----IVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMY 1181
Query: 1064 LVKINTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKI 1103
+ + K + SEE R R ++ + +KE+ +++
Sbjct: 1182 FNEKDDKFHSGSEE---RIRVTFERVEQMCIQIKEVGDRV 1218
Score = 85.9 bits (211), Expect = 2e-16
Identities = 48/152 (31%), Positives = 80/152 (52%), Gaps = 5/152 (3%)
Query: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLA-KVKNDINAAGESEEL 617
+PL L IWA L ++ +++ +W+ AL A K+ +++A + K SEEL
Sbjct: 620 YPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEEL 679
Query: 618 ---ANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674
+N++ AVEL + + DE +A +LL Y + W S CL+LAV + + F+A
Sbjct: 680 KQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCT 739
Query: 675 QNFLSKQWYGEISRDTKNW-KIILCLFIIPLV 705
Q LS W G ++ +W K+IL + + P +
Sbjct: 740 QMLLSDMWMGRLNMRKNSWYKVILSILVPPAI 771
>gi|18921093 transient receptor potential cation channel, subfamily
M, member 6 [Homo sapiens]
Length = 2022
Score = 216 bits (549), Expect = 1e-55
Identities = 151/500 (30%), Positives = 256/500 (51%), Gaps = 45/500 (9%)
Query: 43 NFIQANFKKRECVFFTKDSK----------ATENV--CKCGYAQSQH--------MEGTQ 82
++I+ F KREC SK +N+ C CG H + +
Sbjct: 15 SWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTISAAK 74
Query: 83 INQSEKWNYKKHTKEFPTDAFGDIQFETLGKK---GKYIRLSCDTDAEILYELLTQHWHL 139
+SE+W+ +KHT + PTD FG I F+ G+ KYIR S DT + L L+ + W +
Sbjct: 75 GKESEQWSVEKHTTKSPTDTFGTINFQD-GEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 133
Query: 140 KTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRD 198
+ P LVISV GG +NF + + ++IFS+ L+ A++ GAWI+T G + G+ K++G+ ++
Sbjct: 134 ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKS 193
Query: 199 NTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHT 258
+ S S I +GI WG++ N+ LI + Y D L L++ H+
Sbjct: 194 H--SSHSLRKIWTVGIPPWGVIENQRDLIGKD-----VVCLYQTLDNPLSKLTTLNSMHS 246
Query: 259 HLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINT 318
H +L D+G G E KLR LEKY+S + I + G +P+V GG + ++
Sbjct: 247 HFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQG-VPVVGLVVEGGPNVILSVWE 305
Query: 319 SIKNKIPCVVVEGSGQIADVIASLVE--VEDALTSSAVKEKLVRFLPRTVSRLPEEETES 376
++K+K P VV EG+G+ AD++A + ++ + VKE+++ + T + ++++
Sbjct: 306 TVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFN-FSLKQSKH 364
Query: 377 WIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEW 436
+ L E + +T+ + + + AI AL K + S + QL L + W
Sbjct: 365 LFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASE------QLNLAMAW 418
Query: 437 NQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTEL 496
+++D+A I ++ W+ L++ M AL+ DR FV+L +E G+NL +FLT L EL
Sbjct: 419 DRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEEL 478
Query: 497 FSNH---FSTLVYRNLQIAK 513
++ +TL++ +Q K
Sbjct: 479 YNTKQGPTNTLLHHLVQDVK 498
Score = 185 bits (469), Expect = 2e-46
Identities = 140/620 (22%), Positives = 275/620 (44%), Gaps = 106/620 (17%)
Query: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGE-SEEL 617
+P L +WA+L +++++ W+ T+ A+ A L + +A + + + SEEL
Sbjct: 606 YPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEEL 665
Query: 618 AN---EYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674
N ++ A++L + + +E +A LL Y W S CL+LAV + F++
Sbjct: 666 KNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCT 725
Query: 675 QNFLSKQWYGEISRDTKNW-KIILCLFIIPLVGCGFVSFRKK------PVDKHKKLLWYY 727
Q L+ W G + +W KII+ + + P + + F+ K P + + +WYY
Sbjct: 726 QMLLTDMWMGRLKMRKNSWLKIIISIILPPTILT--LEFKSKAEMSHVPQSQDFQFMWYY 783
Query: 728 ------------------------------------------------VAFFTSPFVVFS 739
F+++P V F
Sbjct: 784 SDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFW 843
Query: 740 WNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFT---- 795
+ + Y+AFL+LF Y +L++ P E ++ +F + VR+ ++ FT
Sbjct: 844 FYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVK 903
Query: 796 ----DLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSR 851
+ WN+ +T+ + F AG V R + +GR+I+C+D I + RL+ F V++
Sbjct: 904 VWISEYWNLTETVAIGLFSAGFVLRWGDPPFHT--AGRLIYCIDIIFWFSRLLDFFAVNQ 961
Query: 852 NLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAM 911
+ GP + M+ +M ++F+ + + A+ +++FGVAR+ IL E + R +++EPY +
Sbjct: 962 HAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMI 1021
Query: 912 FGQV-PSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNIL 970
+G+V ++D + S+P C ++T L +Y+ I+
Sbjct: 1022 YGEVYAGEIDVCS------------SQPSCPP---------GSFLTPFLQAVYLFVQYII 1060
Query: 971 LVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFK 1030
+VNLL+A F ++ ++ +WK+ RY + Y + +P P I+ ++ ++++ +
Sbjct: 1061 MVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLR---R 1117
Query: 1031 CCC-------KEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRHRFR 1083
CC +E ++ + K + + +E E Y + K D + R R
Sbjct: 1118 LCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKY---FHEKMEDVNCSCEERIR 1174
Query: 1084 QLDTKLNDLKGLLKEIANKI 1103
++ ++ LKE+ K+
Sbjct: 1175 VTSERVTEMYFQLKEMNEKV 1194
>gi|45935368 transient receptor potential cation channel, subfamily
M, member 3 isoform h [Homo sapiens]
Length = 230
Score = 151 bits (381), Expect = 4e-36
Identities = 82/227 (36%), Positives = 135/227 (59%), Gaps = 11/227 (4%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY 295
M T +L++ H+H +L DNG G E KLR QLEK+IS + I ++
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKI-NTRI 173
Query: 296 GGKIPIVCFAQGGGKETLKAINTSIKN--KIPCVVVEGSGQIADVIA 340
G +P+V GG + + +++ +P VV +GSG+ +D++A
Sbjct: 174 GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILA 220
>gi|55953096 transient receptor potential cation channel, subfamily
M, member 3 isoform c [Homo sapiens]
Length = 255
Score = 141 bits (355), Expect = 4e-33
Identities = 84/251 (33%), Positives = 135/251 (53%), Gaps = 34/251 (13%)
Query: 117 YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSK 175
Y+R+S DT ++L L+T+ W L+ P L+ISV GG +NF L+P+++++F + LI A +
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 176 GAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGY 235
GAWI TGG + G+++++G+ ++D+ + S I IGIA WG+V N++ LI Y
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPY 119
Query: 236 FLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQ---- 291
M T +L++ H+H +L DNG G E KLR QLEK+IS + I
Sbjct: 120 QTMSNPMSKLT-----VLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCL 174
Query: 292 -----DS---------------NYGGKIPIVCFAQGGGKETLKAINTSIKN--KIPCVVV 329
DS G +P+V GG + + +++ +P VV
Sbjct: 175 PFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVC 234
Query: 330 EGSGQIADVIA 340
+GSG+ +D++A
Sbjct: 235 DGSGRASDILA 245
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 109 bits (272), Expect = 2e-23
Identities = 118/486 (24%), Positives = 208/486 (42%), Gaps = 60/486 (12%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYS- 647
L A S L+ L+KV+N+ + E EEL+ + + A +L + SS E E +L Y
Sbjct: 218 LTAFQLSWELQELSKVENEFKS--EYEELSRQCKQFAKDLLDQTRSSRE--LEIILNYRD 273
Query: 648 ----CEAWGGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILC 698
E G++ L+LA++ + F+AQP Q L+ +WY E ++W K++ C
Sbjct: 274 DNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTC 333
Query: 699 LFI---IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA-- 753
I P+ ++ K P+ F PF+ F + Y+ FL L
Sbjct: 334 FIIGLLFPVFSVCYLIAPKSPLG----------LFIRKPFIKFICHTASYLTFLFLLLLA 383
Query: 754 --YVLLMDFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLF 807
++ D + PP +V + + V E++Q + G+ +Y D WN+MD +
Sbjct: 384 SQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNS 443
Query: 808 YFIAGIVFRLHSSNKSSLYSGR-------------VIFCLDYIIFTLRLIHIFTVSRNLG 854
++A I ++ + K S + R +F + I +LRLI +FT + +LG
Sbjct: 444 LYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLG 503
Query: 855 PKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ 914
P I L RML+D+ FLF++ + ++AF + E+ + + E F
Sbjct: 504 PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAF-- 561
Query: 915 VPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNL 974
T ++ F + F E++ + Y + + ++L+N+
Sbjct: 562 ------STLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNM 615
Query: 975 LVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR-LNIPFPFIVF---AYFYMVVKKCFK 1030
L+AM + + ++ D WKF R L Y +P PF V + ++K +
Sbjct: 616 LIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWT 675
Query: 1031 CCCKEK 1036
CK+K
Sbjct: 676 HLCKKK 681
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 109 bits (272), Expect = 2e-23
Identities = 118/486 (24%), Positives = 208/486 (42%), Gaps = 60/486 (12%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYS- 647
L A S L+ L+KV+N+ + E EEL+ + + A +L + SS E E +L Y
Sbjct: 218 LTAFQLSWELQELSKVENEFKS--EYEELSRQCKQFAKDLLDQTRSSRE--LEIILNYRD 273
Query: 648 ----CEAWGGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILC 698
E G++ L+LA++ + F+AQP Q L+ +WY E ++W K++ C
Sbjct: 274 DNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTC 333
Query: 699 LFI---IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA-- 753
I P+ ++ K P+ F PF+ F + Y+ FL L
Sbjct: 334 FIIGLLFPVFSVCYLIAPKSPLG----------LFIRKPFIKFICHTASYLTFLFLLLLA 383
Query: 754 --YVLLMDFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLF 807
++ D + PP +V + + V E++Q + G+ +Y D WN+MD +
Sbjct: 384 SQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNS 443
Query: 808 YFIAGIVFRLHSSNKSSLYSGR-------------VIFCLDYIIFTLRLIHIFTVSRNLG 854
++A I ++ + K S + R +F + I +LRLI +FT + +LG
Sbjct: 444 LYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLG 503
Query: 855 PKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ 914
P I L RML+D+ FLF++ + ++AF + E+ + + E F
Sbjct: 504 PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAF-- 561
Query: 915 VPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNL 974
T ++ F + F E++ + Y + + ++L+N+
Sbjct: 562 ------STLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNM 615
Query: 975 LVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR-LNIPFPFIVF---AYFYMVVKKCFK 1030
L+AM + + ++ D WKF R L Y +P PF V + ++K +
Sbjct: 616 LIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWT 675
Query: 1031 CCCKEK 1036
CK+K
Sbjct: 676 HLCKKK 681
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 109 bits (272), Expect = 2e-23
Identities = 118/486 (24%), Positives = 208/486 (42%), Gaps = 60/486 (12%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYS- 647
L A S L+ L+KV+N+ + E EEL+ + + A +L + SS E E +L Y
Sbjct: 218 LTAFQLSWELQELSKVENEFKS--EYEELSRQCKQFAKDLLDQTRSSRE--LEIILNYRD 273
Query: 648 ----CEAWGGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILC 698
E G++ L+LA++ + F+AQP Q L+ +WY E ++W K++ C
Sbjct: 274 DNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTC 333
Query: 699 LFI---IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA-- 753
I P+ ++ K P+ F PF+ F + Y+ FL L
Sbjct: 334 FIIGLLFPVFSVCYLIAPKSPLG----------LFIRKPFIKFICHTASYLTFLFLLLLA 383
Query: 754 --YVLLMDFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLF 807
++ D + PP +V + + V E++Q + G+ +Y D WN+MD +
Sbjct: 384 SQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNS 443
Query: 808 YFIAGIVFRLHSSNKSSLYSGR-------------VIFCLDYIIFTLRLIHIFTVSRNLG 854
++A I ++ + K S + R +F + I +LRLI +FT + +LG
Sbjct: 444 LYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLG 503
Query: 855 PKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ 914
P I L RML+D+ FLF++ + ++AF + E+ + + E F
Sbjct: 504 PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAF-- 561
Query: 915 VPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNL 974
T ++ F + F E++ + Y + + ++L+N+
Sbjct: 562 ------STLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNM 615
Query: 975 LVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR-LNIPFPFIVF---AYFYMVVKKCFK 1030
L+AM + + ++ D WKF R L Y +P PF V + ++K +
Sbjct: 616 LIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWT 675
Query: 1031 CCCKEK 1036
CK+K
Sbjct: 676 HLCKKK 681
>gi|7706747 transient receptor potential cation channel, subfamily C,
member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 109 bits (272), Expect = 2e-23
Identities = 118/486 (24%), Positives = 208/486 (42%), Gaps = 60/486 (12%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYS- 647
L A S L+ L+KV+N+ + E EEL+ + + A +L + SS E E +L Y
Sbjct: 218 LTAFQLSWELQELSKVENEFKS--EYEELSRQCKQFAKDLLDQTRSSRE--LEIILNYRD 273
Query: 648 ----CEAWGGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILC 698
E G++ L+LA++ + F+AQP Q L+ +WY E ++W K++ C
Sbjct: 274 DNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTC 333
Query: 699 LFI---IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA-- 753
I P+ ++ K P+ F PF+ F + Y+ FL L
Sbjct: 334 FIIGLLFPVFSVCYLIAPKSPLG----------LFIRKPFIKFICHTASYLTFLFLLLLA 383
Query: 754 --YVLLMDFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLF 807
++ D + PP +V + + V E++Q + G+ +Y D WN+MD +
Sbjct: 384 SQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNS 443
Query: 808 YFIAGIVFRLHSSNKSSLYSGR-------------VIFCLDYIIFTLRLIHIFTVSRNLG 854
++A I ++ + K S + R +F + I +LRLI +FT + +LG
Sbjct: 444 LYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLG 503
Query: 855 PKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ 914
P I L RML+D+ FLF++ + ++AF + E+ + + E F
Sbjct: 504 PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAF-- 561
Query: 915 VPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNL 974
T ++ F + F E++ + Y + + ++L+N+
Sbjct: 562 ------STLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNM 615
Query: 975 LVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR-LNIPFPFIVF---AYFYMVVKKCFK 1030
L+AM + + ++ D WKF R L Y +P PF V + ++K +
Sbjct: 616 LIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWT 675
Query: 1031 CCCKEK 1036
CK+K
Sbjct: 676 HLCKKK 681
>gi|6912736 transient receptor potential cation channel, subfamily C,
member 5 [Homo sapiens]
Length = 973
Score = 102 bits (253), Expect = 3e-21
Identities = 106/449 (23%), Positives = 193/449 (42%), Gaps = 66/449 (14%)
Query: 598 LKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDE---------DLAEQLLVYSC 648
LK L+KV+N+ A E EEL+ + + A +L + SS E D +E+L
Sbjct: 227 LKELSKVENEFKA--EYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEEL---DP 281
Query: 649 EAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWY-GEISRDTKNW--KIILCL---FII 702
+ + L++A++ + F+AQP Q L+ WY G K+W K++ C+ F+
Sbjct: 282 QKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLF 341
Query: 703 PLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA----YVLLM 758
P++ ++ + + F PF+ F + Y+ FL + +++
Sbjct: 342 PMLSIAYLISPRSNLG----------LFIKKPFIKFICHTASYLTFLFMLLLASQHIVRT 391
Query: 759 DFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNG-VNYFTDLWNVMDTLGLFYFIAGIV 814
D H PP +V + + V E+++ + G Y D WN+MD ++A I
Sbjct: 392 DLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATIS 451
Query: 815 FRLHSSNKSSLYSG----------------RVIFCLDYIIFTLRLIHIFTVSRNLGPKII 858
++ + K Y+G +F + I+ +LRLI +FT + +LGP I
Sbjct: 452 LKIVAYVK---YNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQI 508
Query: 859 MLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEP--YLAMFGQVP 916
L RML+D+ FLF++ + ++AF + E R I EP + +
Sbjct: 509 SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETR-------AIDEPNNCKGIRCEKQ 561
Query: 917 SDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLV 976
++ T ++ F + F E++ + Y + + ++L+N+L+
Sbjct: 562 NNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLI 621
Query: 977 AMFGYTVGTVQENNDQVWKFQRYFLVQEY 1005
AM + + ++ D WKF R L Y
Sbjct: 622 AMMNNSYQLIADHADIEWKFARTKLWMSY 650
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 99.0 bits (245), Expect = 2e-20
Identities = 90/327 (27%), Positives = 153/327 (46%), Gaps = 48/327 (14%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYS- 647
L A S L+ L+KV+N+ + E EEL+ + + A +L + SS E E +L Y
Sbjct: 218 LTAFQLSWELQELSKVENEFKS--EYEELSRQCKQFAKDLLDQTRSSRE--LEIILNYRD 273
Query: 648 ----CEAWGGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILC 698
E G++ L+LA++ + F+AQP Q L+ +WY E ++W K++ C
Sbjct: 274 DNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTC 333
Query: 699 LFI---IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA-- 753
I P+ ++ K P+ F PF+ F + Y+ FL L
Sbjct: 334 FIIGLLFPVFSVCYLIAPKSPLG----------LFIRKPFIKFICHTASYLTFLFLLLLA 383
Query: 754 --YVLLMDFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLF 807
++ D + PP +V + + V E++Q + G+ +Y D WN+MD +
Sbjct: 384 SQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNS 443
Query: 808 YFIAGIVFRLHSSNKSSLYSGR-------------VIFCLDYIIFTLRLIHIFTVSRNLG 854
++A I ++ + K S + R +F + I +LRLI +FT + +LG
Sbjct: 444 LYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLG 503
Query: 855 PKIIMLQRMLIDVFFFLFLFAVWMVAF 881
P I L RML+D+ FLF++ + ++AF
Sbjct: 504 PLQISLGRMLLDILKFLFIYCLVLLAF 530
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 94.7 bits (234), Expect = 4e-19
Identities = 93/403 (23%), Positives = 168/403 (41%), Gaps = 49/403 (12%)
Query: 665 DQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILCLFI---IPLVGCGFVSFRKKPVD 718
++ F+AQP Q L+ +WY E ++W K++ C I P+ ++ K P+
Sbjct: 124 EKQFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLG 183
Query: 719 KHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA----YVLLMDFHSVPHPPELVLYSL 774
F PF+ F + Y+ FL L ++ D + PP +V + +
Sbjct: 184 ----------LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMI 233
Query: 775 ---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGR- 829
V E++Q + G+ +Y D WN+MD + ++A I ++ + K S + R
Sbjct: 234 LPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRE 293
Query: 830 ------------VIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVW 877
+F + I +LRLI +FT + +LGP I L RML+D+ FLF++ +
Sbjct: 294 SWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLV 353
Query: 878 MVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESK 937
++AF + E+ + + E F T ++ F
Sbjct: 354 LLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAF--------STLFETLQSLFWSIFGL 405
Query: 938 PLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQ 997
+ F E++ + Y + + ++L+N+L+AM + + ++ D WKF
Sbjct: 406 INLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFA 465
Query: 998 RYFLVQEYCSR-LNIPFPFIVF---AYFYMVVKKCFKCCCKEK 1036
R L Y +P PF V + ++K + CK+K
Sbjct: 466 RTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKK 508
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 67.4 bits (163), Expect = 7e-11
Identities = 111/525 (21%), Positives = 198/525 (37%), Gaps = 113/525 (21%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDE---------DL 639
L AL S L LA ++ + + +L+ + + V + C S+E +
Sbjct: 309 LTALELSNELAKLANIEKEFK--NDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLES 366
Query: 640 AEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCL 699
AE L V+ +A + ++LA++ + F+A P Q L WY +S + I CL
Sbjct: 367 AEPLEVHRHKA--SLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCL 424
Query: 700 FIIPL-VGCGF--VSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVL 756
++ + +G F + + P + K+L SPF+ F + +I FL L +
Sbjct: 425 VVLVVALGLPFLAIGYWIAPCSRLGKIL-------RSPFMKFVAHAASFIIFLGLLVFNA 477
Query: 757 LMDFHSVPHPP----------------------ELVLYSLVFVLFCDEVRQWYVNGVN-Y 793
F + P E+++ V + E ++ ++ G Y
Sbjct: 478 SDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREY 537
Query: 794 FTDLWNVMDTLGLFYFIAGIVFRLHS---SNKSSLYSGRVI------------------- 831
LWNV+D L FIA R + + K+ Y +
Sbjct: 538 ILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTY 597
Query: 832 -----------------FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLF 874
+ + ++ R+ +I + + GP I L R + D+F F+ LF
Sbjct: 598 ARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLF 657
Query: 875 AVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYL-AMFGQVPSDVDGTTYDFAHCTFTG 933
+ AF + ++Y YL A + V+ + F
Sbjct: 658 IMVFFAFMIGM----------------FILYSYYLGAKVNAAFTTVEESFKTLFWSIFGL 701
Query: 934 NESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQV 993
+E + ++ D +F E I L IY ++ ++L+N+L+AM + +++++D
Sbjct: 702 SEVTSVVLKYDH----KFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVE 757
Query: 994 WKFQRYFLVQEYC-SRLNIPFPFIV------FAYFYMVVKKCFKC 1031
WKF R L Y +P PF + F YF M + KC
Sbjct: 758 WKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKC 802
>gi|4507687 transient receptor potential cation channel, subfamily C,
member 3 isoform b [Homo sapiens]
Length = 848
Score = 67.4 bits (163), Expect = 7e-11
Identities = 111/525 (21%), Positives = 198/525 (37%), Gaps = 113/525 (21%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDE---------DL 639
L AL S L LA ++ + + +L+ + + V + C S+E +
Sbjct: 236 LTALELSNELAKLANIEKEFK--NDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLES 293
Query: 640 AEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCL 699
AE L V+ +A + ++LA++ + F+A P Q L WY +S + I CL
Sbjct: 294 AEPLEVHRHKA--SLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCL 351
Query: 700 FIIPL-VGCGF--VSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVL 756
++ + +G F + + P + K+L SPF+ F + +I FL L +
Sbjct: 352 VVLVVALGLPFLAIGYWIAPCSRLGKIL-------RSPFMKFVAHAASFIIFLGLLVFNA 404
Query: 757 LMDFHSVPHPP----------------------ELVLYSLVFVLFCDEVRQWYVNGVN-Y 793
F + P E+++ V + E ++ ++ G Y
Sbjct: 405 SDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREY 464
Query: 794 FTDLWNVMDTLGLFYFIAGIVFRLHS---SNKSSLYSGRVI------------------- 831
LWNV+D L FIA R + + K+ Y +
Sbjct: 465 ILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTY 524
Query: 832 -----------------FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLF 874
+ + ++ R+ +I + + GP I L R + D+F F+ LF
Sbjct: 525 ARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLF 584
Query: 875 AVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYL-AMFGQVPSDVDGTTYDFAHCTFTG 933
+ AF + ++Y YL A + V+ + F
Sbjct: 585 IMVFFAFMIGM----------------FILYSYYLGAKVNAAFTTVEESFKTLFWSIFGL 628
Query: 934 NESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQV 993
+E + ++ D +F E I L IY ++ ++L+N+L+AM + +++++D
Sbjct: 629 SEVTSVVLKYDH----KFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVE 684
Query: 994 WKFQRYFLVQEYC-SRLNIPFPFIV------FAYFYMVVKKCFKC 1031
WKF R L Y +P PF + F YF M + KC
Sbjct: 685 WKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKC 729
>gi|4507685 transient receptor potential cation channel, subfamily C,
member 1 [Homo sapiens]
Length = 759
Score = 63.2 bits (152), Expect = 1e-09
Identities = 110/542 (20%), Positives = 210/542 (38%), Gaps = 92/542 (16%)
Query: 617 LANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQN 676
LA +R +E+ SSDE L ++ L+ E + L+LA++ + F++Q Q
Sbjct: 239 LAQARNSRELEVILNHTSSDEPLDKRGLL---EERMNLSRLKLAIKYNQKEFVSQSNCQQ 295
Query: 677 FLSKQWYGEIS--RDTKNWKIILCLFII----PLVGCGFVSFRKKPVDKHKKLLWYYVAF 730
FL+ W+G++S R K I+ + + P++ ++ K +
Sbjct: 296 FLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGR----------I 345
Query: 731 FTSPFVVFSWNVVFYIAFLL---LFAYVLLMDFHSVPHP-----PELVLYSLVFVLFCDE 782
+PF+ F + Y FLL L++ V D + P L++ ++ +++ D
Sbjct: 346 IHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDI 405
Query: 783 VRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRV------------ 830
R WY ++ + N + + ++A ++ + NK ++ R
Sbjct: 406 KRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAE 465
Query: 831 -IFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGIL 889
+F ++ LRL ++T S LGP I + +ML D FL +F + + +F + +
Sbjct: 466 GLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLY 525
Query: 890 RQN--------------EQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNE 935
+ EQ+ F S I + A+F + + AH
Sbjct: 526 DKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCF-ALFWYI--------FSLAHVA----- 571
Query: 936 SKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWK 995
+ V + ++ +V Y + I+L LLVAM + + + D+ WK
Sbjct: 572 ---IFVTRFSYG-EELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWK 627
Query: 996 FQRYFLVQEYC-SRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNE-----D 1049
F R L Y + +P PF ++ C ++ +C ++
Sbjct: 628 FARAKLWLSYFDDKCTLPPPF-------NIIPSPKTICYMISSLSKWICSHTSKGKVKRQ 680
Query: 1050 NETLAWEGVMK---ENYLVKINTKANDTSEEMRHRFRQLD----TKLNDLKGLLKEIANK 1102
N W + + ENY + + MR + + D LN+L+ L + N+
Sbjct: 681 NSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNE 740
Query: 1103 IK 1104
I+
Sbjct: 741 IR 742
>gi|9966865 transient receptor potential cation channel, subfamily C,
member 7 [Homo sapiens]
Length = 862
Score = 62.4 bits (150), Expect = 2e-09
Identities = 107/527 (20%), Positives = 194/527 (36%), Gaps = 109/527 (20%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLL---- 644
L AL S L LA ++ + + +L+ + + V + C ++E E +L
Sbjct: 240 LTALELSNELARLANIETEFK--NDYRKLSMQCKDFVVGVLDLCRDTEE--VEAILNGDV 295
Query: 645 ---VYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFI 701
V+S + ++LA++ + F+A P Q L WY +S + + L +
Sbjct: 296 NFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAV 355
Query: 702 IPL-VGCGF--VSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLM 758
+ +G F +++ P K + L SPF+ F + V + FL L
Sbjct: 356 FGVSIGLPFLAIAYWIAPCSKLGRTL-------RSPFMKFVAHAVSFTIFLGLLVVNASD 408
Query: 759 DFHSVPHPP----------------------ELVLYSLVFVLFCDEVRQ-WYVNGVNYFT 795
F V P E+++ V + E ++ W Y
Sbjct: 409 RFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVL 468
Query: 796 DLWNVMDTLGLFYFIAGIVFRLHS---SNKSSLYSGRVI--------------------- 831
LWN++D L F+A R + + ++ LY + +
Sbjct: 469 HLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYAR 528
Query: 832 ---------------FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAV 876
+ + ++ R+ +I + + GP I L R + D+F F+ +F +
Sbjct: 529 DKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIM 588
Query: 877 WMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNES 936
VAF + + +R Y P + V+ + F +E
Sbjct: 589 VFVAFMIGMFNLYSY--------YRGAKYNPAF-------TTVEESFKTLFWSIFGLSEV 633
Query: 937 KPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKF 996
+ ++ D +F E I L +Y ++ ++L+N+L+AM + ++E+ D WKF
Sbjct: 634 ISVVLKYDH----KFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKF 689
Query: 997 QRYFLVQEYCSR-LNIPFPFIV------FAYFYMVVKKCFKCCCKEK 1036
R L Y +P PF + F Y M +K C CK K
Sbjct: 690 ARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSK 736
>gi|5730102 transient receptor potential cation channel, subfamily C,
member 6 [Homo sapiens]
Length = 931
Score = 59.3 bits (142), Expect = 2e-08
Identities = 104/521 (19%), Positives = 197/521 (37%), Gaps = 119/521 (22%)
Query: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSC 648
+ AL S L LA ++ + + ++L+ + + V L C +++E E +L
Sbjct: 295 MTALELSNELAVLANIEKEFK--NDYKKLSMQCKDFVVGLLDLCRNTEE--VEAILNGDV 350
Query: 649 EAW-----GGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFI 701
E G N L+LA++ + F+A P Q L WY +S + + L +
Sbjct: 351 ETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVV 410
Query: 702 IPL-VGCGFVS--FRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLM 758
+ + +G F++ + P K K++ PF+ F + + FL L
Sbjct: 411 LAVAIGLPFLALIYWFAPCSKMGKIM-------RGPFMKFVAHAASFTIFLGLLVMNAAD 463
Query: 759 DFHSVPHPP----------------------ELVLYSLVFVLFCDEVRQWYVNGVN-YFT 795
F P E+++ S V + E ++ + G Y
Sbjct: 464 RFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLF 523
Query: 796 DLWNVMDTLGLFYFIAGIVFRL----HSSNKSSLYSGRV--------------------- 830
+LWN++D L F A + R H+S S+
Sbjct: 524 ELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLAR 583
Query: 831 --------------IFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAV 876
++ + ++ R+ +I + + GP I L R + D+F F+ +F +
Sbjct: 584 IKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIM 643
Query: 877 WMVAFGVARQGIL------RQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCT 930
VAF + + +QNE + + E + +F +
Sbjct: 644 VFVAFMIGMFNLYSYYIGAKQNEAF------TTVEESFKTLFWAI--------------- 682
Query: 931 FTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENN 990
F +E K + + + +F E I L +Y ++ I+L+N+L+AM + ++++
Sbjct: 683 FGLSEVKSVVINYNH----KFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDA 738
Query: 991 DQVWKFQR---YFLVQEYCSRLNIPFPFIVF--AYFYMVVK 1026
D WKF R +F E L +PF + + FY+++K
Sbjct: 739 DVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLK 779
>gi|21735483 transient receptor potential cation channel, subfamily V,
member 3 [Homo sapiens]
Length = 790
Score = 51.6 bits (122), Expect = 4e-06
Identities = 64/281 (22%), Positives = 125/281 (44%), Gaps = 46/281 (16%)
Query: 744 FYIAFLLLFAYVLLMDFHSVPHPPELV-------LYSLVFVLF---CDEVRQWYVNGVNY 793
FY L L +Y + ++PHP L L +FVL C V++ +
Sbjct: 450 FYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLR 509
Query: 794 FTDLWNVM-DTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSR- 851
+DL +++ D F F V + S + CL + L ++ +R
Sbjct: 510 PSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACL-VLAMALGWANMLYYTRG 568
Query: 852 --NLGPKIIMLQRMLI-DVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPY 908
++G +M+Q++++ DV FLF++ V+++ FGVA ++ +
Sbjct: 569 FQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEK----------------- 611
Query: 909 LAMFGQVPSD-VDGTTY-DFAHCTFTGNESKPLCVELDEHNLPRFPEW--ITIPLVCIYM 964
P D D ++Y F+ E L + L + N+ + ++ + + L+ Y+
Sbjct: 612 ------CPKDNKDCSSYGSFSDAVL---ELFKLTIGLGDLNIQQNSKYPILFLFLLITYV 662
Query: 965 LSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEY 1005
+ T +LL+N+L+A+ G TV V + ++++W+ QR + E+
Sbjct: 663 ILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEF 703
>gi|22547184 transient receptor potential cation channel, subfamily
V, member 4 isoform a [Homo sapiens]
Length = 871
Score = 47.0 bits (110), Expect = 1e-04
Identities = 66/287 (22%), Positives = 128/287 (44%), Gaps = 44/287 (15%)
Query: 736 VVFSWNVVFYIAFLLLF---AYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVN 792
V F NVV Y+ +++F AY ++ PP ++ ++ EV + +
Sbjct: 469 VSFYINVVSYLCAMVIFTLTAYYQPLE----GTPPYPYRTTVDYLRLAGEVITLFTGVLF 524
Query: 793 YFTDLWNVM-------------DTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIF 839
+FT++ ++ + L YFI ++ + ++LY + L ++F
Sbjct: 525 FFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIV----SAALYLAGIEAYLAVMVF 580
Query: 840 TLRL--IHIFTVSRNL---GPKIIMLQRMLI-DVFFFLFLFAVWMVAFGVARQGILRQNE 893
L L ++ +R L G IM+Q++L D+F FL ++ ++M+ + A +L
Sbjct: 581 ALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCA 640
Query: 894 QRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCV---ELDEHNLPR 950
+ + PS D T+ TF + K L + +L+ + +
Sbjct: 641 N-----MKVCNEDQTNCTVPTYPSCRDSETFS----TFLLDLFK-LTIGMGDLEMLSSTK 690
Query: 951 FPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQ 997
+P + I L+ Y++ T +LL+N+L+A+ G TVG V + + +WK Q
Sbjct: 691 YPV-VFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQ 736
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,582,313
Number of Sequences: 37866
Number of extensions: 1716211
Number of successful extensions: 4260
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 3999
Number of HSP's gapped (non-prelim): 131
length of query: 1104
length of database: 18,247,518
effective HSP length: 113
effective length of query: 991
effective length of database: 13,968,660
effective search space: 13842942060
effective search space used: 13842942060
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.