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Search of human proteins with 14210504
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14210504 adaptor-related protein complex 1, mu 1 subunit
isoform 2 [Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14210504 adaptor-related protein complex 1, mu 1 subunit isof... 849 0.0
gi|194473724 adaptor-related protein complex 1, mu 1 subunit iso... 840 0.0
gi|9506797 adaptor-related protein complex 1, mu 2 subunit [Homo... 702 0.0
gi|68799814 adaptor-related protein complex 2, mu 1 subunit isof... 331 7e-91
gi|14917109 adaptor-related protein complex 2, mu 1 subunit isof... 328 4e-90
gi|14917111 adaptor-related protein complex 4, mu 1 subunit [Hom... 189 4e-48
gi|6912240 adaptor-related protein complex 3, mu 1 subunit [Homo... 186 5e-47
gi|46370095 adaptor-related protein complex 3, mu 1 subunit [Hom... 186 5e-47
gi|197209857 adaptor-related protein complex 3, mu 2 subunit [Ho... 175 6e-44
gi|5803000 adaptor-related protein complex 3, mu 2 subunit [Homo... 175 6e-44
gi|21361863 stonin 2 [Homo sapiens] 75 9e-14
gi|26787993 stonin 1 [Homo sapiens] 73 4e-13
gi|29553944 STON1-GTF2A1L protein [Homo sapiens] 73 4e-13
gi|224451116 Mu-2 related death-inducing protein [Homo sapiens] 40 0.003
gi|11863154 archain isoform 1 [Homo sapiens] 40 0.005
gi|88703051 adaptor-related protein complex 1, sigma 3 subunit [... 33 0.64
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 32 0.83
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 32 0.83
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 32 0.83
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 32 0.83
gi|4557471 adaptor-related protein complex 1, sigma 1 subunit [H... 32 1.4
gi|22027655 adaptor-related protein complex 1 sigma 2 subunit [H... 31 1.9
gi|189409104 adaptor-related protein complex 4, sigma 1 subunit ... 31 1.9
gi|70906430 adaptor-related protein complex 2, sigma 1 subunit i... 31 2.4
gi|229892306 shugoshin-like 2 isoform 1 [Homo sapiens] 30 3.2
gi|229892197 shugoshin-like 2 isoform 3 [Homo sapiens] 30 3.2
gi|94981553 slow cardiac myosin regulatory light chain 2 [Homo s... 30 3.2
gi|11038643 adaptor-related protein complex 2, sigma 1 subunit i... 30 5.4
gi|24430144 glutathione S-transferase alpha 3 [Homo sapiens] 29 7.1
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 29 7.1
>gi|14210504 adaptor-related protein complex 1, mu 1 subunit isoform
2 [Homo sapiens]
Length = 423
Score = 849 bits (2194), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 60
MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
Sbjct: 1 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 60
Query: 61 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 120
KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
Sbjct: 61 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 120
Query: 121 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 180
GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
Sbjct: 121 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 180
Query: 181 LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQ 240
LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQ
Sbjct: 181 LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQ 240
Query: 241 CVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQ 300
CVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQ
Sbjct: 241 CVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQ 300
Query: 301 FKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHF 360
FKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHF
Sbjct: 301 FKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHF 360
Query: 361 GLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQL 420
GLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQL
Sbjct: 361 GLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQL 420
Query: 421 RTQ 423
RTQ
Sbjct: 421 RTQ 423
>gi|194473724 adaptor-related protein complex 1, mu 1 subunit
isoform 1 [Homo sapiens]
Length = 435
Score = 840 bits (2171), Expect = 0.0
Identities = 423/435 (97%), Positives = 423/435 (97%), Gaps = 12/435 (2%)
Query: 1 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 60
MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
Sbjct: 1 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 60
Query: 61 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 120
KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
Sbjct: 61 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 120
Query: 121 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 180
GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
Sbjct: 121 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 180
Query: 181 LL------------VSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 228
LL VSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
Sbjct: 181 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 240
Query: 229 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH 288
KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
Sbjct: 241 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH 300
Query: 289 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF 348
SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
Sbjct: 301 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF 360
Query: 349 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW 408
PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
Sbjct: 361 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW 420
Query: 409 VRYITQNGDYQLRTQ 423
VRYITQNGDYQLRTQ
Sbjct: 421 VRYITQNGDYQLRTQ 435
>gi|9506797 adaptor-related protein complex 1, mu 2 subunit [Homo
sapiens]
Length = 423
Score = 702 bits (1812), Expect = 0.0
Identities = 337/422 (79%), Positives = 389/422 (92%)
Query: 1 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 60
MSASAV++LD+KGK LI RNY+GDV MS++EHFMP+L+++EEEG L+P+L+HG V F+WI
Sbjct: 1 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI 60
Query: 61 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 120
KH+NLYLVAT+ KNA SLV+SFLYK ++VF EYFKELEEESIRDNFVI+YELLDELMDF
Sbjct: 61 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF 120
Query: 121 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 180
G+PQTTDSKILQEYITQ+ +KLETG R P TVTNAVSWRSEGIKY+KNEVF+DVIESVN
Sbjct: 121 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN 180
Query: 181 LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQ 240
LLV+ANG+VL SEIVG+IK++VFLSGMPELRLGLND+VLF+ TGR K+KSVELEDVKFHQ
Sbjct: 181 LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRSKNKSVELEDVKFHQ 240
Query: 241 CVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQ 300
CVRLSRF+NDRTISFIPPDG+FELMSYRL+T VKPLIWIESVIEK SHSR+E M+KAK Q
Sbjct: 241 CVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQ 300
Query: 301 FKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHF 360
FK++S AN VEI +PVP+DADSP+FKT+VGS K+VPE + ++WSIKSFPGGKEYLMRAHF
Sbjct: 301 FKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRAHF 360
Query: 361 GLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQL 420
GLPSVE E+ EG+PPI VKFEIPYFT SGIQVRY+KIIEKSGYQALPWVRYITQ+GDYQL
Sbjct: 361 GLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDYQL 420
Query: 421 RT 422
RT
Sbjct: 421 RT 422
>gi|68799814 adaptor-related protein complex 2, mu 1 subunit isoform
b [Homo sapiens]
Length = 433
Score = 331 bits (849), Expect = 7e-91
Identities = 171/430 (39%), Positives = 265/430 (61%), Gaps = 16/430 (3%)
Query: 6 VYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNL 65
+++ + KG+VLI R YR D+ + V+ F ++ ++ + SP+ F +K +N+
Sbjct: 5 LFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHVKRSNI 63
Query: 66 YLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQT 125
+L A +K+N ++VF FLYK+ V + YF ++ EE+I++NFV+IYELLDE++DFGYPQ
Sbjct: 64 WLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQN 123
Query: 126 TDSKILQEYITQEGHKLETGAPRPPAT--VTNAVSWRSEGIKYRKNEVFLDVIESVNLLV 183
+++ L+ +ITQ+G K +T + T VT + WR EGIKYR+NE+FLDV+ESVNLL+
Sbjct: 124 SETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLM 183
Query: 184 SANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS--------KSVELED 235
S G VL + + G + M+ +LSGMPE + G+NDK++ + G+G + +S+ ++D
Sbjct: 184 SPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDD 243
Query: 236 VKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMI 295
FHQCVRLS+F+++R+ISFIPPDGEFELM YR + + ++ + +++E +
Sbjct: 244 CTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKV 303
Query: 296 KAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYL 355
KS FK A +E+ IP P + + G K+ + IVW IK G KE
Sbjct: 304 VIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQ 363
Query: 356 MRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEK----SGYQALPWVRY 411
+ A L + K +PPIS+ FE+P F SG++VRYLK+ E S + + WVRY
Sbjct: 364 ISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIKWVRY 422
Query: 412 ITQNGDYQLR 421
I ++G Y+ R
Sbjct: 423 IGRSGIYETR 432
>gi|14917109 adaptor-related protein complex 2, mu 1 subunit isoform
a [Homo sapiens]
Length = 435
Score = 328 bits (842), Expect = 4e-90
Identities = 169/432 (39%), Positives = 265/432 (61%), Gaps = 18/432 (4%)
Query: 6 VYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNL 65
+++ + KG+VLI R YR D+ + V+ F ++ ++ + SP+ F +K +N+
Sbjct: 5 LFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHVKRSNI 63
Query: 66 YLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQT 125
+L A +K+N ++VF FLYK+ V + YF ++ EE+I++NFV+IYELLDE++DFGYPQ
Sbjct: 64 WLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQN 123
Query: 126 TDSKILQEYITQEG----HKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNL 181
+++ L+ +ITQ+G H+ + + + VT + WR EGIKYR+NE+FLDV+ESVNL
Sbjct: 124 SETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNL 183
Query: 182 LVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS--------KSVEL 233
L+S G VL + + G + M+ +LSGMPE + G+NDK++ + G+G + +S+ +
Sbjct: 184 LMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAI 243
Query: 234 EDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEY 293
+D FHQCVRLS+F+++R+ISFIPPDGEFELM YR + + ++ + +++E
Sbjct: 244 DDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEV 303
Query: 294 MIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKE 353
+ KS FK A +E+ IP P + + G K+ + IVW IK G KE
Sbjct: 304 KVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKE 363
Query: 354 YLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEK----SGYQALPWV 409
+ A L + K +PPIS+ FE+P F SG++VRYLK+ E S + + WV
Sbjct: 364 SQISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIKWV 422
Query: 410 RYITQNGDYQLR 421
RYI ++G Y+ R
Sbjct: 423 RYIGRSGIYETR 434
>gi|14917111 adaptor-related protein complex 4, mu 1 subunit [Homo
sapiens]
Length = 453
Score = 189 bits (480), Expect = 4e-48
Identities = 126/455 (27%), Positives = 224/455 (49%), Gaps = 42/455 (9%)
Query: 4 SAVYVLDLKGKVLICRNYRGDV---DMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 60
S ++L KG LI +++RGD D++E+ + + +E + ++ H G F+ I
Sbjct: 3 SQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPV---VMHHHGRHFIHI 59
Query: 61 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 120
+H+ LYLV T+ +N + L ++ + +Y L E +I N ++YELLDE++D+
Sbjct: 60 RHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDY 119
Query: 121 GYPQTTDSKILQEYITQE------------------GHKLETGAPRPPATVTNAV-SWRS 161
GY QTT +++L+ +I E G + + P + + V S RS
Sbjct: 120 GYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRS 179
Query: 162 EGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFD 221
+ + +KNEVFLDV+E +++L+++NG++L+ ++ G I+++ FL E+R+GL ++
Sbjct: 180 D--QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVG 237
Query: 222 NTG-RGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVK---PLI 277
+ RG + +++V FH V L FE+ R + PP GE +M Y+L+ + P
Sbjct: 238 KSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFR 297
Query: 278 WIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPE 337
SV R++ +K + +S A NV +H+P+P S + + K
Sbjct: 298 LFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELA 357
Query: 338 NSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKP---------PISVKFEIPYFTTS 388
+ W + GG + +P G P S+ FE+P T S
Sbjct: 358 EGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCS 417
Query: 389 GIQVRYLKIIEKSGYQALP--WVRYITQNGDYQLR 421
G+QVR+L++ + A P WVR+++ + Y +R
Sbjct: 418 GLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIR 452
>gi|6912240 adaptor-related protein complex 3, mu 1 subunit [Homo
sapiens]
Length = 418
Score = 186 bits (471), Expect = 5e-47
Identities = 118/433 (27%), Positives = 213/433 (49%), Gaps = 33/433 (7%)
Query: 5 AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64
++++++ G + + ++++ V S ++F + + + P+++ + I +
Sbjct: 4 SLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDK 63
Query: 65 LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124
L+ V+ + V FL++V F +YF E E +I+DN VI+YELL+E++D G+P
Sbjct: 64 LFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPL 123
Query: 125 TTDSKILQEYI----------TQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLD 174
T+S IL+E I G P ++N + WR G+KY NE + D
Sbjct: 124 ATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSN-IPWRRAGVKYTNNEAYFD 182
Query: 175 VIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELE 234
V+E ++ ++ +G+ + +EI G I + LSGMP+L L + L L+
Sbjct: 183 VVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRL-------------LD 229
Query: 235 DVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTH--VKPLIWIESVI---EKHSHS 289
DV FH C+R R+E++R +SFIPPDG F L+SYR+++ V ++++ I E S
Sbjct: 230 DVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCG 289
Query: 290 RIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFP 349
R + I K + T + + + +P + T GS + P + W +
Sbjct: 290 RFDITIGPKQNMGK--TIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKIT 347
Query: 350 GGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWV 409
K ++ L S A E P ++++F+I SG++V L + + Y+ V
Sbjct: 348 PQKLPSLKGLVNLQS-GAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEK-YKPFKGV 405
Query: 410 RYITQNGDYQLRT 422
+Y+T+ G +Q+RT
Sbjct: 406 KYVTKAGKFQVRT 418
>gi|46370095 adaptor-related protein complex 3, mu 1 subunit [Homo
sapiens]
Length = 418
Score = 186 bits (471), Expect = 5e-47
Identities = 118/433 (27%), Positives = 213/433 (49%), Gaps = 33/433 (7%)
Query: 5 AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64
++++++ G + + ++++ V S ++F + + + P+++ + I +
Sbjct: 4 SLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDK 63
Query: 65 LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124
L+ V+ + V FL++V F +YF E E +I+DN VI+YELL+E++D G+P
Sbjct: 64 LFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPL 123
Query: 125 TTDSKILQEYI----------TQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLD 174
T+S IL+E I G P ++N + WR G+KY NE + D
Sbjct: 124 ATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSN-IPWRRAGVKYTNNEAYFD 182
Query: 175 VIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELE 234
V+E ++ ++ +G+ + +EI G I + LSGMP+L L + L L+
Sbjct: 183 VVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRL-------------LD 229
Query: 235 DVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTH--VKPLIWIESVI---EKHSHS 289
DV FH C+R R+E++R +SFIPPDG F L+SYR+++ V ++++ I E S
Sbjct: 230 DVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCG 289
Query: 290 RIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFP 349
R + I K + T + + + +P + T GS + P + W +
Sbjct: 290 RFDITIGPKQNMGK--TIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKIT 347
Query: 350 GGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWV 409
K ++ L S A E P ++++F+I SG++V L + + Y+ V
Sbjct: 348 PQKLPSLKGLVNLQS-GAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEK-YKPFKGV 405
Query: 410 RYITQNGDYQLRT 422
+Y+T+ G +Q+RT
Sbjct: 406 KYVTKAGKFQVRT 418
>gi|197209857 adaptor-related protein complex 3, mu 2 subunit [Homo
sapiens]
Length = 418
Score = 175 bits (444), Expect = 6e-44
Identities = 115/437 (26%), Positives = 207/437 (47%), Gaps = 41/437 (9%)
Query: 5 AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64
++++++ G + + ++++ V S ++F E + P++ + + +
Sbjct: 4 SLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHK 63
Query: 65 LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124
++ VA + V FL++VV F +YF E I+DN V++YE+L+E++D G+P
Sbjct: 64 IFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPL 123
Query: 125 TTDSKILQEYI----------------TQEGHKLETGAPRPPATVTNAVSWRSEGIKYRK 168
T+S IL+E I T G +L TG + V WR G+KY
Sbjct: 124 ATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQ-------LSVVPWRRTGVKYTN 176
Query: 169 NEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 228
NE + DVIE ++ ++ +G+ + +EI G I V L+GMP+L L + L
Sbjct: 177 NEAYFDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRL--------- 227
Query: 229 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRL---NTHVKPLIWIESVIEK 285
L+DV FH CVR R+E++R +SFIPPDG F L+SY + N P+ ++ +
Sbjct: 228 ----LDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFR 283
Query: 286 HSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSI 345
S S + I + T V + +P + + G+ + P + W +
Sbjct: 284 DSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDV 343
Query: 346 KSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQA 405
K ++ L + ++ E P I+++F+I SG++V L + + Y+
Sbjct: 344 GKINPQKLPSLKGTMSLQAGASKPDE-NPTINLQFKIQQLAISGLKVNRLDMYGEK-YKP 401
Query: 406 LPWVRYITQNGDYQLRT 422
++Y+T+ G +Q+RT
Sbjct: 402 FKGIKYMTKAGKFQVRT 418
>gi|5803000 adaptor-related protein complex 3, mu 2 subunit [Homo
sapiens]
Length = 418
Score = 175 bits (444), Expect = 6e-44
Identities = 115/437 (26%), Positives = 207/437 (47%), Gaps = 41/437 (9%)
Query: 5 AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64
++++++ G + + ++++ V S ++F E + P++ + + +
Sbjct: 4 SLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHK 63
Query: 65 LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124
++ VA + V FL++VV F +YF E I+DN V++YE+L+E++D G+P
Sbjct: 64 IFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPL 123
Query: 125 TTDSKILQEYI----------------TQEGHKLETGAPRPPATVTNAVSWRSEGIKYRK 168
T+S IL+E I T G +L TG + V WR G+KY
Sbjct: 124 ATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQ-------LSVVPWRRTGVKYTN 176
Query: 169 NEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 228
NE + DVIE ++ ++ +G+ + +EI G I V L+GMP+L L + L
Sbjct: 177 NEAYFDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRL--------- 227
Query: 229 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRL---NTHVKPLIWIESVIEK 285
L+DV FH CVR R+E++R +SFIPPDG F L+SY + N P+ ++ +
Sbjct: 228 ----LDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFR 283
Query: 286 HSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSI 345
S S + I + T V + +P + + G+ + P + W +
Sbjct: 284 DSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDV 343
Query: 346 KSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQA 405
K ++ L + ++ E P I+++F+I SG++V L + + Y+
Sbjct: 344 GKINPQKLPSLKGTMSLQAGASKPDE-NPTINLQFKIQQLAISGLKVNRLDMYGEK-YKP 401
Query: 406 LPWVRYITQNGDYQLRT 422
++Y+T+ G +Q+RT
Sbjct: 402 FKGIKYMTKAGKFQVRT 418
>gi|21361863 stonin 2 [Homo sapiens]
Length = 905
Score = 75.5 bits (184), Expect = 9e-14
Identities = 75/304 (24%), Positives = 119/304 (39%), Gaps = 57/304 (18%)
Query: 163 GIKYRKNEVFLDVIESVNLLVSANGN-VLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFD 221
G+ Y + E+ +DV + + +VS N +L+ ++ I + FLSG+ E RLGLND ++
Sbjct: 563 GLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKG 622
Query: 222 N--------TGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDG-EFELMSYRLNTH 272
N +K ++L + +FH CV F N R I F P D FELM +R
Sbjct: 623 NEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFA 682
Query: 273 VKPLIWI--------ESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPND----- 319
K L + + +E S R+ A + NV I PVP++
Sbjct: 683 EKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKNF 742
Query: 320 ---------------------------ADSPKFKTTVGSVKWVPENSEIVWSIKSFP--- 349
P + T+G+ K+ + IVW I P
Sbjct: 743 RRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKN 802
Query: 350 --GGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALP 407
G + H L S ++V+F +P + S VR + + +K+ +
Sbjct: 803 SASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISVEDKTDVR--K 860
Query: 408 WVRY 411
WV Y
Sbjct: 861 WVNY 864
>gi|26787993 stonin 1 [Homo sapiens]
Length = 735
Score = 73.2 bits (178), Expect = 4e-13
Identities = 67/283 (23%), Positives = 110/283 (38%), Gaps = 51/283 (18%)
Query: 166 YRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGR 225
Y + E+ L+++++ V+ G + S ++ I F++G E L LND L
Sbjct: 410 YEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLNDLELPKRDES 469
Query: 226 -----GKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDG-EFELMSYR--LNTHVKPLI 277
+ K +++ D FH+CV + FE R I F+P D FELM ++ N P
Sbjct: 470 YYEKDSEKKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNGDNLPFS 529
Query: 278 WIESVIEKHSHSRIEYMIKAKSQFKRRSTA------NNVEIHIPVPND------------ 319
V+ + ++ ++ + S +R S A +N+ IH PVP+
Sbjct: 530 LKSVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTMNLQR 589
Query: 320 --------------------ADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAH 359
P + TVGS K+ +VW I P L H
Sbjct: 590 QKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPH 649
Query: 360 -----FGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKI 397
L S + + P +V+F +P S +VR L +
Sbjct: 650 CLSYKLELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGV 692
>gi|29553944 STON1-GTF2A1L protein [Homo sapiens]
Length = 1182
Score = 73.2 bits (178), Expect = 4e-13
Identities = 67/283 (23%), Positives = 110/283 (38%), Gaps = 51/283 (18%)
Query: 166 YRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGR 225
Y + E+ L+++++ V+ G + S ++ I F++G E L LND L
Sbjct: 410 YEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLNDLELPKRDES 469
Query: 226 -----GKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDG-EFELMSYR--LNTHVKPLI 277
+ K +++ D FH+CV + FE R I F+P D FELM ++ N P
Sbjct: 470 YYEKDSEKKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNGDNLPFS 529
Query: 278 WIESVIEKHSHSRIEYMIKAKSQFKRRSTA------NNVEIHIPVPND------------ 319
V+ + ++ ++ + S +R S A +N+ IH PVP+
Sbjct: 530 LKSVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTMNLQR 589
Query: 320 --------------------ADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAH 359
P + TVGS K+ +VW I P L H
Sbjct: 590 QKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPH 649
Query: 360 -----FGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKI 397
L S + + P +V+F +P S +VR L +
Sbjct: 650 CLSYKLELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGV 692
>gi|224451116 Mu-2 related death-inducing protein [Homo sapiens]
Length = 490
Score = 40.4 bits (93), Expect = 0.003
Identities = 65/298 (21%), Positives = 107/298 (35%), Gaps = 46/298 (15%)
Query: 77 VSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYIT 136
VS F FL+ + Y + + + + +LL + FG T LQ +
Sbjct: 128 VSQGFEFLFGIQDFL--YSGQKNDSELNTKLSQLPDLLLQACPFG---TLLDANLQNSLD 182
Query: 137 QEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESV-NLLVSANGNVLRSEIV 195
T + PA W++ G K +V + + E V ++ G ++V
Sbjct: 183 NTNFASVTQPQKQPA-------WKT-GTYKGKPQVSISITEKVKSMQYDKQGIADTWQVV 234
Query: 196 GSIKMRVFLSG-MPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRL---------- 244
G++ + L G MP + + L+ + L+D+ H CV
Sbjct: 235 GTVTCKCDLEGIMPNVTISLSLP----------TNGSPLQDILVHPCVTSLDSAILTSSS 284
Query: 245 ------SRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAK 298
S F F PP F L Y V P++ + E+ RI +K
Sbjct: 285 IDAMDDSAFSGPYKFPFTPPLESFNLCFYTSQVPVPPILGFYQMKEEEVQLRITINLKLH 344
Query: 299 SQFKRRSTANNVEIHIPVPNDADSP--KFKTTVGSVKWVPENSEIVWSI-KSFPGGKE 353
K + E HIP N ++KT+ G ++ E S ++W I + FP E
Sbjct: 345 ESVK--NNFEFCEAHIPFYNRGPITHLEYKTSFGQLEVFREKSLLIWIIGQKFPKSME 400
>gi|11863154 archain isoform 1 [Homo sapiens]
Length = 511
Score = 39.7 bits (91), Expect = 0.005
Identities = 27/137 (19%), Positives = 58/137 (42%), Gaps = 1/137 (0%)
Query: 5 AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64
A V GK ++ R + ++ + +E + + G + VR+++
Sbjct: 5 AAAVCTKAGKAIVSRQFV-EMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEK 63
Query: 65 LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124
LY+V + KN+ + L +V EY + LEE I ++ + DE++ GY +
Sbjct: 64 LYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRE 123
Query: 125 TTDSKILQEYITQEGHK 141
+ ++ + + H+
Sbjct: 124 NVNLAQIRTFTEMDSHE 140
>gi|88703051 adaptor-related protein complex 1, sigma 3 subunit
[Homo sapiens]
Length = 154
Score = 32.7 bits (73), Expect = 0.64
Identities = 22/90 (24%), Positives = 40/90 (44%)
Query: 55 VRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELL 114
++ ++ ++ +LY + L +++ V++ +YF + E I NF Y +L
Sbjct: 55 LKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFIL 114
Query: 115 DELMDFGYPQTTDSKILQEYITQEGHKLET 144
DE + G Q T KI + I ET
Sbjct: 115 DEFIIGGEIQETSKKIAVKAIEDSDMLQET 144
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 32.3 bits (72), Expect = 0.83
Identities = 37/157 (23%), Positives = 71/157 (45%), Gaps = 8/157 (5%)
Query: 163 GIKYRKNEVFLDVIESVNLLVSANG--NVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLF 220
G+ R+ +DV+E +NLL++ +G N LR + ++ ++ L PE+ +
Sbjct: 1033 GLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKI-LHNDPEVEKKQGWTTVG 1091
Query: 221 DNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIP-PDGEFELMSYRLNTHVKPLIWI 279
D G G + V+ E +KF S E ++ P P +F + +PL+ +
Sbjct: 1092 DMEGCGHYRVVKYERIKFLVIALKSSVE---VYAWAPKPYHKFMAFKSFADLPHRPLL-V 1147
Query: 280 ESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPV 316
+ +E+ ++ Y A + N+ +I+IPV
Sbjct: 1148 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV 1184
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 32.3 bits (72), Expect = 0.83
Identities = 37/157 (23%), Positives = 71/157 (45%), Gaps = 8/157 (5%)
Query: 163 GIKYRKNEVFLDVIESVNLLVSANG--NVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLF 220
G+ R+ +DV+E +NLL++ +G N LR + ++ ++ L PE+ +
Sbjct: 1024 GLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKI-LHNDPEVEKKQGWTTVG 1082
Query: 221 DNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIP-PDGEFELMSYRLNTHVKPLIWI 279
D G G + V+ E +KF S E ++ P P +F + +PL+ +
Sbjct: 1083 DMEGCGHYRVVKYERIKFLVIALKSSVE---VYAWAPKPYHKFMAFKSFADLPHRPLL-V 1138
Query: 280 ESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPV 316
+ +E+ ++ Y A + N+ +I+IPV
Sbjct: 1139 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV 1175
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 32.3 bits (72), Expect = 0.83
Identities = 37/157 (23%), Positives = 71/157 (45%), Gaps = 8/157 (5%)
Query: 163 GIKYRKNEVFLDVIESVNLLVSANG--NVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLF 220
G+ R+ +DV+E +NLL++ +G N LR + ++ ++ L PE+ +
Sbjct: 1053 GLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKI-LHNDPEVEKKQGWTTVG 1111
Query: 221 DNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIP-PDGEFELMSYRLNTHVKPLIWI 279
D G G + V+ E +KF S E ++ P P +F + +PL+ +
Sbjct: 1112 DMEGCGHYRVVKYERIKFLVIALKSSVE---VYAWAPKPYHKFMAFKSFADLPHRPLL-V 1167
Query: 280 ESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPV 316
+ +E+ ++ Y A + N+ +I+IPV
Sbjct: 1168 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV 1204
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 32.3 bits (72), Expect = 0.83
Identities = 37/157 (23%), Positives = 71/157 (45%), Gaps = 8/157 (5%)
Query: 163 GIKYRKNEVFLDVIESVNLLVSANG--NVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLF 220
G+ R+ +DV+E +NLL++ +G N LR + ++ ++ L PE+ +
Sbjct: 1016 GLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKI-LHNDPEVEKKQGWTTVG 1074
Query: 221 DNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIP-PDGEFELMSYRLNTHVKPLIWI 279
D G G + V+ E +KF S E ++ P P +F + +PL+ +
Sbjct: 1075 DMEGCGHYRVVKYERIKFLVIALKSSVE---VYAWAPKPYHKFMAFKSFADLPHRPLL-V 1130
Query: 280 ESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPV 316
+ +E+ ++ Y A + N+ +I+IPV
Sbjct: 1131 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPV 1167
>gi|4557471 adaptor-related protein complex 1, sigma 1 subunit [Homo
sapiens]
Length = 158
Score = 31.6 bits (70), Expect = 1.4
Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 5/129 (3%)
Query: 12 KGKVLICRNYRGDVDMSE---VEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLV 68
+GK+ + + Y D V M +++ ++ + + L ++ ++ ++ +LY
Sbjct: 11 QGKLRLQKWYLATSDKERKKMVRELMQVVLARKPK--MCSFLEWRDLKVVYKRYASLYFC 68
Query: 69 ATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDS 128
+ + +++ V++ +YF + E I NF Y +LDE + G Q T
Sbjct: 69 CAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMGGDVQDTSK 128
Query: 129 KILQEYITQ 137
K + + I Q
Sbjct: 129 KSVLKAIEQ 137
>gi|22027655 adaptor-related protein complex 1 sigma 2 subunit [Homo
sapiens]
Length = 157
Score = 31.2 bits (69), Expect = 1.9
Identities = 19/83 (22%), Positives = 39/83 (46%)
Query: 55 VRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELL 114
++ ++ ++ +LY + + +++ V++ +YF + E I NF Y +L
Sbjct: 54 LKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFIL 113
Query: 115 DELMDFGYPQTTDSKILQEYITQ 137
DE + G Q T K + + I Q
Sbjct: 114 DEFLLGGEVQETSKKNVLKAIEQ 136
>gi|189409104 adaptor-related protein complex 4, sigma 1 subunit
isoform 2 [Homo sapiens]
Length = 144
Score = 31.2 bits (69), Expect = 1.9
Identities = 14/63 (22%), Positives = 32/63 (50%)
Query: 56 RFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLD 115
+ ++ ++ L++V ++ F++ V+V EYF + E I N ++ +LD
Sbjct: 56 KLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILD 115
Query: 116 ELM 118
E++
Sbjct: 116 EMV 118
>gi|70906430 adaptor-related protein complex 2, sigma 1 subunit
isoform AP17 [Homo sapiens]
Length = 142
Score = 30.8 bits (68), Expect = 2.4
Identities = 15/53 (28%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 84 LYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFG-YPQTTDSKILQEYI 135
++ V+V +EYF + E + NF +Y ++DE+ G +T+ +K+L++ +
Sbjct: 84 IHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLL 136
>gi|229892306 shugoshin-like 2 isoform 1 [Homo sapiens]
Length = 1265
Score = 30.4 bits (67), Expect = 3.2
Identities = 41/180 (22%), Positives = 73/180 (40%), Gaps = 24/180 (13%)
Query: 233 LEDVKFHQCV-----RLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHS 287
+E++K +C +++ R S P E+M R+ V+ + +K +
Sbjct: 1059 VEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVME-RILDSVQGKSTVSEQADKEN 1117
Query: 288 HSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKS 347
+ E M+K K F ++ + EIH PN DS G V S
Sbjct: 1118 NLENEKMVKNKPDFYTKAFRSLSEIH--SPNIQDSSFDSVREGLVP------------LS 1163
Query: 348 FPGGKEYLMRAHFGL---PSVEAEDKEGKPPISVKFEIPYFT-TSGIQVRYLKIIEKSGY 403
GK +++ +F L P+ + D E + +KF++ T SGI R L+ + + +
Sbjct: 1164 VSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSF 1223
>gi|229892197 shugoshin-like 2 isoform 3 [Homo sapiens]
Length = 1261
Score = 30.4 bits (67), Expect = 3.2
Identities = 41/180 (22%), Positives = 73/180 (40%), Gaps = 24/180 (13%)
Query: 233 LEDVKFHQCV-----RLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHS 287
+E++K +C +++ R S P E+M R+ V+ + +K +
Sbjct: 1059 VEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVME-RILDSVQGKSTVSEQADKEN 1117
Query: 288 HSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKS 347
+ E M+K K F ++ + EIH PN DS G V S
Sbjct: 1118 NLENEKMVKNKPDFYTKAFRSLSEIH--SPNIQDSSFDSVREGLVP------------LS 1163
Query: 348 FPGGKEYLMRAHFGL---PSVEAEDKEGKPPISVKFEIPYFT-TSGIQVRYLKIIEKSGY 403
GK +++ +F L P+ + D E + +KF++ T SGI R L+ + + +
Sbjct: 1164 VSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSF 1223
>gi|94981553 slow cardiac myosin regulatory light chain 2 [Homo
sapiens]
Length = 166
Score = 30.4 bits (67), Expect = 3.2
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 7/74 (9%)
Query: 193 EIVGSIKMRVFLSGMPELRLG-------LNDKVLFDNTGRGKSKSVELEDVKFHQCVRLS 245
E G I VFL+ E G LN +FD G+G K+ + ++ Q R S
Sbjct: 72 EAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLKADYVREMLTTQAERFS 131
Query: 246 RFENDRTISFIPPD 259
+ E D+ + PPD
Sbjct: 132 KEEVDQMFAAFPPD 145
>gi|11038643 adaptor-related protein complex 2, sigma 1 subunit
isoform AP17delta [Homo sapiens]
Length = 104
Score = 29.6 bits (65), Expect = 5.4
Identities = 15/49 (30%), Positives = 30/49 (61%), Gaps = 1/49 (2%)
Query: 88 VQVFSEYFKELEEESIRDNFVIIYELLDELMDFG-YPQTTDSKILQEYI 135
V+V +EYF + E + NF +Y ++DE+ G +T+ +K+L++ +
Sbjct: 50 VEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLL 98
>gi|24430144 glutathione S-transferase alpha 3 [Homo sapiens]
Length = 222
Score = 29.3 bits (64), Expect = 7.1
Identities = 38/158 (24%), Positives = 63/158 (39%), Gaps = 31/158 (19%)
Query: 6 VYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRF------MW 59
+Y D+K + LI G D++E+ +P+ +E++ ++ I R+ +
Sbjct: 81 LYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAKIALIKEKTKSRYFPAFEKVL 140
Query: 60 IKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMD 119
H YLV A +SLV LY Y +EL + S+ NF ++ L + +
Sbjct: 141 QSHGQDYLVGNKLSRADISLV-ELLY--------YVEEL-DSSLISNFPLLKALKTRISN 190
Query: 120 FGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAV 157
T K LQ G+PR P A+
Sbjct: 191 L----PTVKKFLQ-----------PGSPRKPPADAKAL 213
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 29.3 bits (64), Expect = 7.1
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 12/72 (16%)
Query: 344 SIKSFPGGKEYLMRAHFGLP----------SVEAEDKEGKPPISVKFEIPYFTTSGIQVR 393
+++SFPG KEY ++A G+ +++A+DK G PP ++ + T+ +
Sbjct: 305 TVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK-GTPPQFSSVKVIHVTSPQFKAG 363
Query: 394 YLKIIEKSGYQA 405
+K EK Y+A
Sbjct: 364 PVK-FEKDVYRA 374
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,164,339
Number of Sequences: 37866
Number of extensions: 727013
Number of successful extensions: 1634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1573
Number of HSP's gapped (non-prelim): 39
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.