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Search of human proteins with 9998944
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9998944 amiloride-sensitive cation channel 1, neuronal
isoform 2 [Homo sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 1048 0.0
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 780 0.0
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 716 0.0
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 694 0.0
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 517 e-147
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 517 e-147
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 517 e-146
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 446 e-125
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 421 e-118
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 224 1e-58
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 152 5e-37
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 148 1e-35
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 148 1e-35
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 148 1e-35
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 118 1e-26
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 111 2e-24
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 111 2e-24
gi|75709187 cleavage stimulation factor subunit 3 isoform 2 [Hom... 32 1.4
gi|4758378 vascular endothelial growth factor D preproprotein [H... 32 1.8
gi|239754668 PREDICTED: mucin 12 [Homo sapiens] 30 6.8
gi|89026265 PREDICTED: mucin 12 [Homo sapiens] 30 6.8
gi|239743293 PREDICTED: mucin 12 [Homo sapiens] 30 6.8
gi|4557495 cleavage stimulation factor subunit 3 isoform 1 [Homo... 30 6.8
gi|209954808 ets-related isoform 4 [Homo sapiens] 29 8.9
gi|4758300 ets-related isoform 2 [Homo sapiens] 29 8.9
gi|33667107 ets-related isoform 1 [Homo sapiens] 29 8.9
gi|209954797 ets-related isoform 3 [Homo sapiens] 29 8.9
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi... 29 8.9
gi|68508961 centromere protein C 1 [Homo sapiens] 29 8.9
gi|46276868 hypothetical protein LOC9710 [Homo sapiens] 29 8.9
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 1048 bits (2709), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVES 60
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVES
Sbjct: 1 MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVES 60
Query: 61 SERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVN 120
SERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVN
Sbjct: 61 SERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVN 120
Query: 121 LQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGH 180
LQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGH
Sbjct: 121 LQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGH 180
Query: 181 QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF 240
QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF
Sbjct: 181 QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF 240
Query: 241 EAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFP 300
EAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFP
Sbjct: 241 EAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFP 300
Query: 301 VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLC 360
VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLC
Sbjct: 301 VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLC 360
Query: 361 RTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK 420
RTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK
Sbjct: 361 RTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK 420
Query: 421 KAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVS 480
KAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVS
Sbjct: 421 KAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVS 480
Query: 481 TCDTMPNHSETISHTVNVPLQTTLGTLEEIAC 512
TCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
Sbjct: 481 TCDTMPNHSETISHTVNVPLQTTLGTLEEIAC 512
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 780 bits (2015), Expect = 0.0
Identities = 397/504 (78%), Positives = 425/504 (84%), Gaps = 23/504 (4%)
Query: 26 LHGIRHIFV----YGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVA 81
LHG+RH+ G RR LW +AF S GLLL SS R+ Y+ S+ T+V +
Sbjct: 66 LHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWS 125
Query: 82 QSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALR--- 138
+ L FPAVT+CN N RF RL+ DLY+AG L LL N A P V E LR
Sbjct: 126 RQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPN------RTARPLVSELLRGDE 179
Query: 139 -------QKANFKHY-KPKQFSMLE--FLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFT 188
+ A+F+ + P+ F + F+ R+GH L+DM+L CK++G+ CG +F++VFT
Sbjct: 180 PRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFT 239
Query: 189 KYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQI 248
KYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQI
Sbjct: 240 KYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQI 299
Query: 249 HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACR 308
HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACR
Sbjct: 300 HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACR 359
Query: 309 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 368
IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR
Sbjct: 360 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 419
Query: 369 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428
YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL
Sbjct: 420 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 479
Query: 429 LGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNH 488
LGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNH
Sbjct: 480 LGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNH 539
Query: 489 SETISHTVNVPLQTTLGTLEEIAC 512
SETISHTVNVPLQTTLGTLEEIAC
Sbjct: 540 SETISHTVNVPLQTTLGTLEEIAC 563
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 716 bits (1847), Expect = 0.0
Identities = 349/528 (66%), Positives = 407/528 (77%), Gaps = 16/528 (3%)
Query: 1 MDLKESPSE-GSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVE 59
M+LK E G +QP SIQ FA++STLHG+ HIF Y L+++R LWA+ F+GSL +LL
Sbjct: 1 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
Query: 60 SSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDV 119
+ERV YYF Y HVTK+DEV A L FPAVTLCNLN FRFS+++ NDLYHAGELLALL+
Sbjct: 61 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 120
Query: 120 NLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECG 179
+IPD +AD LE L+ KANF+ +KPK F+M EF R GHD++DM+L C F+G+ C
Sbjct: 121 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 180
Query: 180 HQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETT 239
+DF VFT+YGKCY FNSG DG+P L T+KGGTGNGLEIMLDIQQDEYLP+WGET+ET+
Sbjct: 181 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 240
Query: 240 FEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM--GLD 297
FEAG+KVQIHSQ EPPFI +LGFGVAPGFQTFVA QEQRL YLPPPWG C++ M LD
Sbjct: 241 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 300
Query: 298 FFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNY 357
FF YSITACRIDCETRY+VENCNCRMVHMPGDAP+CTPEQ+KECA+PAL L EKD Y
Sbjct: 301 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 360
Query: 358 CLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETI 417
C+C PCNLTRY KELSMVKIPSK SAKYL KKFNKSE+YI ENILVLDIFFE LNYETI
Sbjct: 361 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 420
Query: 418 EQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLL--DLLGKEEDEGSH 475
EQKKAYE+A LLGDIGGQMGLFIGASILT+LELFDY YE+IK KL KE S
Sbjct: 421 EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA 480
Query: 476 DENV----------STCDTMPNHSETISHTVNV-PLQTTLGTLEEIAC 512
D+ V + C+++ H +++ N+ P GT E+ C
Sbjct: 481 DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 528
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 694 bits (1790), Expect = 0.0
Identities = 349/574 (60%), Positives = 407/574 (70%), Gaps = 62/574 (10%)
Query: 1 MDLKESPSE-GSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVE 59
M+LK E G +QP SIQ FA++STLHG+ HIF Y L+++R LWA+ F+GSL +LL
Sbjct: 1 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
Query: 60 SSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDV 119
+ERV YYF Y HVTK+DEV A L FPAVTLCNLN FRFS+++ NDLYHAGELLALL+
Sbjct: 61 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 120
Query: 120 NLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECG 179
+IPD +AD LE L+ KANF+ +KPK F+M EF R GHD++DM+L C F+G+ C
Sbjct: 121 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 180
Query: 180 HQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETT 239
+DF VFT+YGKCY FNSG DG+P L T+KGGTGNGLEIMLDIQQDEYLP+WGET+ET+
Sbjct: 181 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 240
Query: 240 FEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM--GLD 297
FEAG+KVQIHSQ EPPFI +LGFGVAPGFQTFVA QEQRL YLPPPWG C++ M LD
Sbjct: 241 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 300
Query: 298 FFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNY 357
FF YSITACRIDCETRY+VENCNCRMVHMPGDAP+CTPEQ+KECA+PAL L EKD Y
Sbjct: 301 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 360
Query: 358 CLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETI 417
C+C PCNLTRY KELSMVKIPSK SAKYL KKFNKSE+YI ENILVLDIFFE LNYETI
Sbjct: 361 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 420
Query: 418 EQKKAYEVAAL----------------------------------------------LGD 431
EQKKAYE+A L LGD
Sbjct: 421 EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD 480
Query: 432 IGGQMGLFIGASILTILELFDYIYELIKEKLL--DLLGKEEDEGSHDENV---------- 479
IGGQMGLFIGASILT+LELFDY YE+IK KL KE S D+ V
Sbjct: 481 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH 540
Query: 480 STCDTMPNHSETISHTVNV-PLQTTLGTLEEIAC 512
+ C+++ H +++ N+ P GT E+ C
Sbjct: 541 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 574
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 517 bits (1332), Expect = e-147
Identities = 252/504 (50%), Positives = 336/504 (66%), Gaps = 26/504 (5%)
Query: 7 PSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSY 66
P E S I++FA+ ++HG+ H+F G L++RR +WA A V S+ L + +ERV Y
Sbjct: 7 PEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRY 66
Query: 67 YFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDP 126
Y + H T +DE + L+FPAVTLCN+N R SRLT NDL+ AG L LD P
Sbjct: 67 YREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAE 121
Query: 127 HLADPSVLEALRQKANFKHYKPKQ-FSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTT 185
H A L AL + + P F M + R GH L DM+L C+F+GQ CG ++FTT
Sbjct: 122 HAA---FLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTT 178
Query: 186 VFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVK 245
+FT+ GKCY FNSG DG LLTT +GG GNGL+IMLD+QQ+EYLP+W + EET FE G++
Sbjct: 179 IFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIR 238
Query: 246 VQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDF------- 298
VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ + ++
Sbjct: 239 VQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDP 298
Query: 299 --------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLL 350
P Y++ CR+ CETRY+ C CRMV+MPGD P C+P+Q+K CA PA+ +
Sbjct: 299 LGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAM 358
Query: 351 AEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFE 410
KDS C C PC TRY KELSMV+IPS+ +A++L +K N+SE YI+EN+L LDIFFE
Sbjct: 359 LRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFE 416
Query: 411 ALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEE 470
ALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ ++K+L +
Sbjct: 417 ALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQ 476
Query: 471 DEGSHDENVSTCDTMPNHSETISH 494
H + + +H + H
Sbjct: 477 HSQRHSSTNLLQEGLGSHRTQVPH 500
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 517 bits (1332), Expect = e-147
Identities = 252/504 (50%), Positives = 336/504 (66%), Gaps = 26/504 (5%)
Query: 7 PSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSY 66
P E S I++FA+ ++HG+ H+F G L++RR +WA A V S+ L + +ERV Y
Sbjct: 7 PEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRY 66
Query: 67 YFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDP 126
Y + H T +DE + L+FPAVTLCN+N R SRLT NDL+ AG L LD P
Sbjct: 67 YREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAE 121
Query: 127 HLADPSVLEALRQKANFKHYKPKQ-FSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTT 185
H A L AL + + P F M + R GH L DM+L C+F+GQ CG ++FTT
Sbjct: 122 HAA---FLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTT 178
Query: 186 VFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVK 245
+FT+ GKCY FNSG DG LLTT +GG GNGL+IMLD+QQ+EYLP+W + EET FE G++
Sbjct: 179 IFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIR 238
Query: 246 VQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDF------- 298
VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ + ++
Sbjct: 239 VQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDP 298
Query: 299 --------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLL 350
P Y++ CR+ CETRY+ C CRMV+MPGD P C+P+Q+K CA PA+ +
Sbjct: 299 LGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAM 358
Query: 351 AEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFE 410
KDS C C PC TRY KELSMV+IPS+ +A++L +K N+SE YI+EN+L LDIFFE
Sbjct: 359 LRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFE 416
Query: 411 ALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEE 470
ALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ ++K+L +
Sbjct: 417 ALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQ 476
Query: 471 DEGSHDENVSTCDTMPNHSETISH 494
H + + +H + H
Sbjct: 477 HSQRHSSTNLLQEGLGSHRTQVPH 500
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 517 bits (1331), Expect = e-146
Identities = 252/503 (50%), Positives = 340/503 (67%), Gaps = 27/503 (5%)
Query: 7 PSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSY 66
P E S I++FA+ ++HG+ H+F G L++RR +WA A V S+ L + +ERV Y
Sbjct: 7 PEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRY 66
Query: 67 YFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDP 126
Y + H T +DE + L+FPAVTLCN+N R SRLT NDL+ AG L LD P
Sbjct: 67 YREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAE 121
Query: 127 HLADPSVLEALRQKANFKHYKPKQ-FSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTT 185
H A L AL + + P F M + R GH L DM+L C+F+GQ CG ++FTT
Sbjct: 122 HAA---FLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTT 178
Query: 186 VFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVK 245
+FT+ GKCY FNSG DG LLTT +GG GNGL+IMLD+QQ+EYLP+W + EET FE G++
Sbjct: 179 IFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIR 238
Query: 246 VQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDF------- 298
VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ + ++
Sbjct: 239 VQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDP 298
Query: 299 --------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLL 350
P Y++ CR+ CETRY+ C CRMV+MPGD P C+P+Q+K CA PA+ +
Sbjct: 299 LGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAM 358
Query: 351 AEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFE 410
KDS C C PC TRY KELSMV+IPS+ +A++L +K N+SE YI+EN+L LDIFFE
Sbjct: 359 LRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFE 416
Query: 411 ALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEE 470
ALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ ++K+L +
Sbjct: 417 ALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQ 476
Query: 471 DEGSHDE-NVSTCDTMPNHSETI 492
H N+++ ++ H +++
Sbjct: 477 HSQRHSSTNLTSHPSLCRHQDSL 499
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 446 bits (1148), Expect = e-125
Identities = 226/454 (49%), Positives = 299/454 (65%), Gaps = 24/454 (5%)
Query: 14 PSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHV 73
P + FA+TSTLHG+ GP +RR LWA+A + SL L +++ Y + H+
Sbjct: 166 PRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHL 225
Query: 74 TKVDEVVAQSLV-FPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPS 132
+D + FPAVTLCN+N FR S L+ D++H L L + D H A
Sbjct: 226 VAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDR---DGHRA--- 279
Query: 133 VLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGK 192
A ++ +P M++ L+R GH L DM+ C F G C +F+ V+T+YGK
Sbjct: 280 --------AGLRYPEP---DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGK 328
Query: 193 CYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQS 252
CY FN+ D + L + GG G+GLEIMLDIQQ+EYLPIW ET ET+FEAG++VQIHSQ
Sbjct: 329 CYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQE 386
Query: 253 EPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSS----EMGLDFFPVYSITACR 308
EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PWG CR+ E L + YS++ACR
Sbjct: 387 EPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACR 446
Query: 309 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 368
+ CE +++ C+CRMVHMPG+ C P + ECA+ L L C C TPCNLTR
Sbjct: 447 LRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNLTR 506
Query: 369 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428
Y KE+SMV+IP++ SA+YL +K+N++E YI EN LVLD+FFEAL E +EQ+ AY ++AL
Sbjct: 507 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 566
Query: 429 LGDIGGQMGLFIGASILTILELFDYIYELIKEKL 462
LGD+GGQMGLFIGASILT+LE+ DYIYE+ ++L
Sbjct: 567 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 600
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 421 bits (1082), Expect = e-118
Identities = 219/454 (48%), Positives = 289/454 (63%), Gaps = 43/454 (9%)
Query: 14 PSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHV 73
P + FA+TSTLHG+ GP +RR LWA+A + SL L +++ Y + H+
Sbjct: 166 PRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHL 225
Query: 74 TKVDEVVAQSLV-FPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPS 132
+D + FPAVTLCN+N FR S L+ D++H L L + D H A
Sbjct: 226 VAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDR---DGHRA--- 279
Query: 133 VLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGK 192
A ++ +P M++ L+R GH L DM+ C F G C +F+ V+T+YGK
Sbjct: 280 --------AGLRYPEP---DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGK 328
Query: 193 CYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQS 252
CY FN+ D + L + GG G+GLEIMLDIQQ+EYLPIW ET ET+FEAG++VQIHSQ
Sbjct: 329 CYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQE 386
Query: 253 EPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSS----EMGLDFFPVYSITACR 308
EPP+I +LGFGV+PGFQTFV+ QEQRLTYLP PWG CR+ E L + YS++ACR
Sbjct: 387 EPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACR 446
Query: 309 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 368
+ CE +++ C+CRMVHMP L C C TPCNLTR
Sbjct: 447 LRCEKEAVLQRCHCRMVHMPDS-------------------LGGGPEGPCFCPTPCNLTR 487
Query: 369 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428
Y KE+SMV+IP++ SA+YL +K+N++E YI EN LVLD+FFEAL E +EQ+ AY ++AL
Sbjct: 488 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 547
Query: 429 LGDIGGQMGLFIGASILTILELFDYIYELIKEKL 462
LGD+GGQMGLFIGASILT+LE+ DYIYE+ ++L
Sbjct: 548 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDRL 581
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 224 bits (572), Expect = 1e-58
Identities = 141/446 (31%), Positives = 231/446 (51%), Gaps = 28/446 (6%)
Query: 20 FANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEV 79
FA +++ HGI +I V IRRVLW V +GS+ L+ + R+ YF++ T ++
Sbjct: 41 FAISTSFHGIHNI-VQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
Query: 80 VAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQ 139
+ + FPAVT CNLN F+ T+ + G + L + ++ HL + + +
Sbjct: 100 YVEKMEFPAVTFCNLNRFQ-----TDAVAKFGVIFFLWHIVSKVL--HLQEITANSTGSR 152
Query: 140 KANFKHYKPKQFSMLEFLHRVGHDLKDM-MLYCKFKGQECGHQDFTTVFTKYGKCYMFNS 198
+A + FS++EF+ G L + +L C+F G+ C +DF VFT+YG C+ FN
Sbjct: 153 EATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNH 212
Query: 199 GE--DGKPLLTTVKGGTGNGLEIMLDIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEP 254
GE K ++ +G GL ++ ++ Q+ + P G + AG+ IHS +
Sbjct: 213 GETLQAKRKVSV----SGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKV 263
Query: 255 PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETR 314
P LG G V ++ + + PWGEC + + L F YS + C +C+ +
Sbjct: 264 PQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN-IKLQNFSSYSTSGCLKECKAQ 322
Query: 315 YIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKD-----SNYCLCRTPCNLTRY 369
+I + C C +PG C +++ C P L + KD ++ C C Y
Sbjct: 323 HIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEY 382
Query: 370 NKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALL 429
+S PS+ + KYL KK N+S KYI EN++ ++I + LNY+ +Q+KA V+ LL
Sbjct: 383 PATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELL 442
Query: 430 GDIGGQMGLFIGASILTILELFDYIY 455
D+GGQ+GLF GAS++TI+E+ +Y++
Sbjct: 443 ADLGGQLGLFCGASLITIIEIIEYLF 468
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 152 bits (385), Expect = 5e-37
Identities = 98/356 (27%), Positives = 172/356 (48%), Gaps = 26/356 (7%)
Query: 165 KDMMLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDI 223
+ M+L C F + C +++FT++F YG CY+FN G K L + GT GL+++LDI
Sbjct: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKAL-PSANPGTEFGLKLILDI 301
Query: 224 QQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLP 283
Q++Y+P T AGV++ +H Q PFI++ G G +T + +L +
Sbjct: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355
Query: 284 PPWGEC--RSSEMGL-----DFFPVYSITACRIDCETRYIVENCNCR--MVHMPGDAPFC 334
P+ C SE+ + D+ YSI AC C +++ NCNC + +P +C
Sbjct: 356 EPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYC 415
Query: 335 TPEQHKECAEPALGL---LAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYL---- 387
+ A L +A++++ +C+ CN T+Y +SM PS+ S ++
Sbjct: 416 NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVL 475
Query: 388 --EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASIL 445
E+ + + + I+ L+I+F+ NY TIE+ A + LL ++GGQ G ++G S+L
Sbjct: 476 SQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVL 535
Query: 446 TILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQ 501
++E + I + + ++ L+ + S P +E + N Q
Sbjct: 536 CLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQ 591
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 148 bits (374), Expect = 1e-35
Identities = 121/534 (22%), Positives = 228/534 (42%), Gaps = 93/534 (17%)
Query: 18 QIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVD 77
+ F N +T+HG + ++ WAV ++ + G++ + YFSY ++
Sbjct: 119 EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN 178
Query: 78 EVVAQSLVFPAVTLCNLNGF-------------RFSRLTTNDLYHAGELLALL------- 117
+ + LVFPAVT+C LN + R + T DLY L+
Sbjct: 179 -LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRR 237
Query: 118 DVNLQIPDP--HLADP----------SVLEALRQ---KANFKHYKPK------------- 149
D+ +P P L P SV +LR + ++K +K
Sbjct: 238 DLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFY 297
Query: 150 --------------QFSMLEFLHRVGHDLKDM--------MLYCKFKGQECGHQDFTTVF 187
+F + L R+ L + + C+F C +++
Sbjct: 298 QTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFH 357
Query: 188 -TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKV 246
YG CY FN + ++++ G NGL +ML +Q++++P+ G +V
Sbjct: 358 HPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAEQNDFIPLLSTV------TGARV 410
Query: 247 QIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-Y 302
+H Q EP F+ + GF + PG +T ++ +++ L L +G+C + + + +P Y
Sbjct: 411 MVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKY 470
Query: 303 SITACRIDCETRYIVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--C 358
+ C C +++ C C + P + +C +H L + S++ C
Sbjct: 471 TQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGC 530
Query: 359 L--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEAL 412
CR PC++T Y + PS TS +++ + ++ Y N + ++IFF+ L
Sbjct: 531 FTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKEL 590
Query: 413 NYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLL 466
NY+T + + + LL ++G Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 591 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 644
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 148 bits (374), Expect = 1e-35
Identities = 121/534 (22%), Positives = 228/534 (42%), Gaps = 93/534 (17%)
Query: 18 QIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVD 77
+ F N +T+HG + ++ WAV ++ + G++ + YFSY ++
Sbjct: 83 EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN 142
Query: 78 EVVAQSLVFPAVTLCNLNGF-------------RFSRLTTNDLYHAGELLALL------- 117
+ + LVFPAVT+C LN + R + T DLY L+
Sbjct: 143 -LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRR 201
Query: 118 DVNLQIPDP--HLADP----------SVLEALRQ---KANFKHYKPK------------- 149
D+ +P P L P SV +LR + ++K +K
Sbjct: 202 DLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFY 261
Query: 150 --------------QFSMLEFLHRVGHDLKDM--------MLYCKFKGQECGHQDFTTVF 187
+F + L R+ L + + C+F C +++
Sbjct: 262 QTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFH 321
Query: 188 -TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKV 246
YG CY FN + ++++ G NGL +ML +Q++++P+ G +V
Sbjct: 322 HPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAEQNDFIPLLSTV------TGARV 374
Query: 247 QIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-Y 302
+H Q EP F+ + GF + PG +T ++ +++ L L +G+C + + + +P Y
Sbjct: 375 MVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKY 434
Query: 303 SITACRIDCETRYIVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--C 358
+ C C +++ C C + P + +C +H L + S++ C
Sbjct: 435 TQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGC 494
Query: 359 L--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEAL 412
CR PC++T Y + PS TS +++ + ++ Y N + ++IFF+ L
Sbjct: 495 FTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKEL 554
Query: 413 NYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLL 466
NY+T + + + LL ++G Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 555 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 608
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 148 bits (374), Expect = 1e-35
Identities = 121/534 (22%), Positives = 228/534 (42%), Gaps = 93/534 (17%)
Query: 18 QIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVD 77
+ F N +T+HG + ++ WAV ++ + G++ + YFSY ++
Sbjct: 60 EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN 119
Query: 78 EVVAQSLVFPAVTLCNLNGF-------------RFSRLTTNDLYHAGELLALL------- 117
+ + LVFPAVT+C LN + R + T DLY L+
Sbjct: 120 -LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRR 178
Query: 118 DVNLQIPDP--HLADP----------SVLEALRQ---KANFKHYKPK------------- 149
D+ +P P L P SV +LR + ++K +K
Sbjct: 179 DLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFY 238
Query: 150 --------------QFSMLEFLHRVGHDLKDM--------MLYCKFKGQECGHQDFTTVF 187
+F + L R+ L + + C+F C +++
Sbjct: 239 QTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFH 298
Query: 188 -TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKV 246
YG CY FN + ++++ G NGL +ML +Q++++P+ G +V
Sbjct: 299 HPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAEQNDFIPLLSTV------TGARV 351
Query: 247 QIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGL---DFFPV-Y 302
+H Q EP F+ + GF + PG +T ++ +++ L L +G+C + + + +P Y
Sbjct: 352 MVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKY 411
Query: 303 SITACRIDCETRYIVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGLLAEKDSNY--C 358
+ C C +++ C C + P + +C +H L + S++ C
Sbjct: 412 TQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGC 471
Query: 359 L--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN----ILVLDIFFEAL 412
CR PC++T Y + PS TS +++ + ++ Y N + ++IFF+ L
Sbjct: 472 FTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKEL 531
Query: 413 NYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLL 466
NY+T + + + LL ++G Q L+ G+S+L+++E+ + +++L+ L LL
Sbjct: 532 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLL 585
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 118 bits (295), Expect = 1e-26
Identities = 84/327 (25%), Positives = 149/327 (45%), Gaps = 40/327 (12%)
Query: 154 LEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGG 212
LE + + +++++ C F G C ++FT +G CY FN+ E+ + +L+T GG
Sbjct: 243 LEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNREN-ETILSTSMGG 301
Query: 213 TGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFV 272
+ GL+++L I ++EY P G KV IH Q E PF++++G + T +
Sbjct: 302 SEYGLQVILYINEEEYNPF------LVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSI 355
Query: 273 ATQEQRLTYLPPPWGECRSSEMGLD------FFPVYSITACRIDCETRYIVENCNCRMVH 326
L P+ +C +E G D + YS+ C C +VE C C
Sbjct: 356 GMHLTESFKLSEPYSQC--TEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYS 413
Query: 327 --MPGDAPFCTPEQHKECA----EPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPS 380
+P A +C +QH + + E+ +C+ C+ + S+ + PS
Sbjct: 414 QPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPS 473
Query: 381 KTSAKYL------------EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 428
S K+L KK NK++ + L IF++ LN +I + A + L
Sbjct: 474 VVSEKWLLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANSIEML 527
Query: 429 LGDIGGQMGLFIGASILTILELFDYIY 455
L + GGQ+GL++ S++ ++E+ + +
Sbjct: 528 LSNFGGQLGLWMSCSVVCVIEIIEVFF 554
Score = 42.0 bits (97), Expect = 0.001
Identities = 29/79 (36%), Positives = 47/79 (59%), Gaps = 5/79 (6%)
Query: 22 NTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVA 81
NT+T HG R I V +RR+LW + ++ L+L + + V FS+ V+ +V
Sbjct: 35 NTNT-HGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCALLV---FSFYTVSVSIKVHF 89
Query: 82 QSLVFPAVTLCNLNGFRFS 100
+ L FPAVT+CN+N +++S
Sbjct: 90 RKLDFPAVTICNINPYKYS 108
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 111 bits (277), Expect = 2e-24
Identities = 73/305 (23%), Positives = 141/305 (46%), Gaps = 28/305 (9%)
Query: 168 MLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 226
+L C + G +C + F T YG CY + + T + G +G+ ++L ++Q
Sbjct: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQRPGITHGVGLVLRVEQQ 313
Query: 227 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 286
+LP+ AG++V +H ++ PF+ F V PG + ++ +E + L P+
Sbjct: 314 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 367
Query: 287 GECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-VH-MPGDAPFCTPEQHK 340
G C + G++ + Y+ AC + C + +VE C+C +H +P A +C+ +H
Sbjct: 368 GHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHP 427
Query: 341 ECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPSKTSAKYL-----EKKF 391
L + +++ C + PC + + + PS SA + E+
Sbjct: 428 AWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGL 487
Query: 392 NKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELF 451
++ ++I ++ LNY ++E+ Y V LL +G L+ GAS+L++LEL
Sbjct: 488 PHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELL 547
Query: 452 DYIYE 456
+ + +
Sbjct: 548 ELLLD 552
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 111 bits (277), Expect = 2e-24
Identities = 73/305 (23%), Positives = 141/305 (46%), Gaps = 28/305 (9%)
Query: 168 MLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQD 226
+L C + G +C + F T YG CY + + T + G +G+ ++L ++Q
Sbjct: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG------VWTAQRPGITHGVGLVLRVEQQ 379
Query: 227 EYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPW 286
+LP+ AG++V +H ++ PF+ F V PG + ++ +E + L P+
Sbjct: 380 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 433
Query: 287 GECRSSEMGLDFFPV----YSITACRIDCETRYIVENCNCRM-VH-MPGDAPFCTPEQHK 340
G C + G++ + Y+ AC + C + +VE C+C +H +P A +C+ +H
Sbjct: 434 GHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHP 493
Query: 341 ECAEPALGLLAEKDSNYCLCRT----PCNLTRYNKELSMVKIPSKTSAKYL-----EKKF 391
L + +++ C + PC + + + PS SA + E+
Sbjct: 494 AWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGL 553
Query: 392 NKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELF 451
++ ++I ++ LNY ++E+ Y V LL +G L+ GAS+L++LEL
Sbjct: 554 PHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELL 613
Query: 452 DYIYE 456
+ + +
Sbjct: 614 ELLLD 618
>gi|75709187 cleavage stimulation factor subunit 3 isoform 2 [Homo
sapiens]
Length = 103
Score = 32.0 bits (71), Expect = 1.4
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 380 SKTSAKYLEKKFNKSEKYISENILVLD----IFFEALNYETIEQKKAYE-VAALLGDIGG 434
++ +A+Y+ +K K+EK + EN LD + EA N + +K YE + A G
Sbjct: 7 TEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGR 66
Query: 435 QMGLFIGASILTILELFDYIY 455
L+I A + + F Y Y
Sbjct: 67 FWKLYIEAEVTILFYFFLYQY 87
>gi|4758378 vascular endothelial growth factor D preproprotein [Homo
sapiens]
Length = 354
Score = 31.6 bits (70), Expect = 1.8
Identities = 16/57 (28%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 311 CETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPAL---GLLAEKDSNYCLCRTPC 364
C + ++ C+ V + + P E H EPAL ++ ++D C+C+TPC
Sbjct: 222 CPIDMLWDSNKCKCV-LQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPC 277
>gi|239754668 PREDICTED: mucin 12 [Homo sapiens]
Length = 1952
Score = 29.6 bits (65), Expect = 6.8
Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 14/82 (17%)
Query: 181 QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF 240
Q+FTT ++ G S P TTV G L + + G TE T F
Sbjct: 1437 QEFTTPHSQPGSALSTVS-----PASTTVPG---------LSEESTTFYSSPGSTETTAF 1482
Query: 241 EAGVKVQIHSQSEPPFIQELGF 262
+ IHSQ PF GF
Sbjct: 1483 SHSNTMSIHSQQSTPFPDSPGF 1504
>gi|89026265 PREDICTED: mucin 12 [Homo sapiens]
Length = 978
Score = 29.6 bits (65), Expect = 6.8
Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 14/82 (17%)
Query: 181 QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF 240
Q+FTT ++ G S P TTV G L + + G TE T F
Sbjct: 466 QEFTTPHSQPGSALSTVS-----PASTTVPG---------LSEESTTFYSSPGSTETTAF 511
Query: 241 EAGVKVQIHSQSEPPFIQELGF 262
+ IHSQ PF GF
Sbjct: 512 SHSNTMSIHSQQSTPFPDSPGF 533
>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
Length = 5478
Score = 29.6 bits (65), Expect = 6.8
Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 14/82 (17%)
Query: 181 QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTF 240
Q+FTT ++ G S P TTV G L + + G TE T F
Sbjct: 4963 QEFTTPHSQPGSALSTVS-----PASTTVPG---------LSEESTTFYSSPGSTETTAF 5008
Query: 241 EAGVKVQIHSQSEPPFIQELGF 262
+ IHSQ PF GF
Sbjct: 5009 SHSNTMSIHSQQSTPFPDSPGF 5030
>gi|4557495 cleavage stimulation factor subunit 3 isoform 1 [Homo
sapiens]
Length = 717
Score = 29.6 bits (65), Expect = 6.8
Identities = 26/92 (28%), Positives = 46/92 (50%), Gaps = 7/92 (7%)
Query: 380 SKTSAKYLEKKFNKSEKYISENILVLD----IFFEALNYETIEQKKAYE-VAALLGDIGG 434
++ +A+Y+ +K K+EK + EN LD + EA N + +K YE + A G
Sbjct: 7 TEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGR 66
Query: 435 QMGLFIGASILTILELFDYIYELIKEKLLDLL 466
L+I A I + +D + +L + L+ +L
Sbjct: 67 FWKLYIEAEIKA--KNYDKVEKLFQRCLMKVL 96
>gi|209954808 ets-related isoform 4 [Homo sapiens]
Length = 387
Score = 29.3 bits (64), Expect = 8.9
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 91 LCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKH 145
LC + F RLT + Y+A LL+ L + P PHL V +AL+ H
Sbjct: 76 LCKMTKDDFQRLTPS--YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMH 128
>gi|4758300 ets-related isoform 2 [Homo sapiens]
Length = 462
Score = 29.3 bits (64), Expect = 8.9
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 91 LCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKH 145
LC + F RLT + Y+A LL+ L + P PHL V +AL+ H
Sbjct: 175 LCKMTKDDFQRLTPS--YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMH 227
>gi|33667107 ets-related isoform 1 [Homo sapiens]
Length = 479
Score = 29.3 bits (64), Expect = 8.9
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 91 LCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKH 145
LC + F RLT + Y+A LL+ L + P PHL V +AL+ H
Sbjct: 168 LCKMTKDDFQRLTPS--YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMH 220
>gi|209954797 ets-related isoform 3 [Homo sapiens]
Length = 486
Score = 29.3 bits (64), Expect = 8.9
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 91 LCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKH 145
LC + F RLT + Y+A LL+ L + P PHL V +AL+ H
Sbjct: 175 LCKMTKDDFQRLTPS--YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMH 227
>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
sapiens]
Length = 261
Score = 29.3 bits (64), Expect = 8.9
Identities = 14/44 (31%), Positives = 20/44 (45%)
Query: 150 QFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKC 193
Q +L+ HR G DL DM ++ CG D + G+C
Sbjct: 54 QTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRC 97
>gi|68508961 centromere protein C 1 [Homo sapiens]
Length = 943
Score = 29.3 bits (64), Expect = 8.9
Identities = 14/53 (26%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 456 ELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLE 508
+L K+K LD + +++N+ T +P +T +T N+P ++ L + E
Sbjct: 624 DLAKKKNLDC-SRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGE 675
>gi|46276868 hypothetical protein LOC9710 [Homo sapiens]
Length = 1070
Score = 29.3 bits (64), Expect = 8.9
Identities = 19/62 (30%), Positives = 25/62 (40%), Gaps = 3/62 (4%)
Query: 222 DIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTY 281
D Q P+W T + + A VQ Q PP + GF+ F E+R Y
Sbjct: 1010 DTMQMLQSPVWAATNDCSAAAFSYVQTPPQPPPPPAHK---AAPKGFKAFPGKGERRPAY 1066
Query: 282 LP 283
LP
Sbjct: 1067 LP 1068
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,256,773
Number of Sequences: 37866
Number of extensions: 929171
Number of successful extensions: 2071
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1991
Number of HSP's gapped (non-prelim): 36
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.