Search of human proteins with 9910430

Search of human proteins with 9910430

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9910430 matrix, extracellular phosphoglycoprotein with ASARM
motif (bone) [Homo sapiens]
         (525 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9910430 matrix, extracellular phosphoglycoprotein with ASARM ...  1071   0.0  
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    53   8e-07
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]    45   2e-04
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu...    41   0.003
gi|118600971 transcription elongation factor A (SII)-like 6 [Hom...    40   0.005
gi|60097902 filaggrin [Homo sapiens]                                   39   0.009
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    39   0.009
gi|42518068 trans-golgi network protein 2 [Homo sapiens]               39   0.009
gi|61175239 transcription elongation factor A (SII)-like 5 [Homo...    39   0.009
gi|125656165 THO complex 2 [Homo sapiens]                              39   0.012
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    39   0.015
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni...    38   0.026
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit...    38   0.026
gi|55749431 transcription elongation factor A (SII)-like 3 [Homo...    38   0.026
gi|14249718 transcription elongation factor A (SII)-like 3 [Homo...    38   0.026
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    37   0.044
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    37   0.044
gi|226423889 myocardin isoform 1 [Homo sapiens]                        37   0.058
gi|23957692 myocardin isoform 2 [Homo sapiens]                         37   0.058
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre...    37   0.058
gi|226423891 myocardin isoform 3 [Homo sapiens]                        37   0.058
gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo ...    36   0.075
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    36   0.075
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    36   0.075
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    36   0.075
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    36   0.075
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]       36   0.075
gi|47778921 alpha 1 type XIX collagen precursor [Homo sapiens]         36   0.099
gi|55749769 CWC22 spliceosome-associated protein homolog [Homo s...    36   0.099
gi|212549782 caspase 8 associated protein 2 [Homo sapiens]             35   0.13 

>gi|9910430 matrix, extracellular phosphoglycoprotein with ASARM
           motif (bone) [Homo sapiens]
          Length = 525

 Score = 1071 bits (2770), Expect = 0.0
 Identities = 525/525 (100%), Positives = 525/525 (100%)

Query: 1   MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSS 60
           MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSS
Sbjct: 1   MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSS 60

Query: 61  KENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKS 120
           KENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKS
Sbjct: 61  KENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKS 120

Query: 121 TGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNII 180
           TGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNII
Sbjct: 121 TGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNII 180

Query: 181 PASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSG 240
           PASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSG
Sbjct: 181 PASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSG 240

Query: 241 YTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKK 300
           YTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKK
Sbjct: 241 YTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKK 300

Query: 301 PGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDA 360
           PGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDA
Sbjct: 301 PGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDA 360

Query: 361 GSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQAT 420
           GSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQAT
Sbjct: 361 GSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQAT 420

Query: 421 LNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNST 480
           LNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNST
Sbjct: 421 LNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNST 480

Query: 481 RNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD 525
           RNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD
Sbjct: 481 RNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD 525


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 80/490 (16%), Positives = 167/490 (34%), Gaps = 40/490 (8%)

Query: 35  QRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQ 94
           Q+ E  NK  +G  + G   N +     +   +  +    + + E+ G+  + +   N  
Sbjct: 428 QKSEPGNK--VGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNS 485

Query: 95  RLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGD-DAISKLHDQEEYGAALIRNNMQH 153
               + S ++ E+  NG         + +KG ED D D+ S  ++ +  G     NN   
Sbjct: 486 SSRGDASYNSDESKDNG-------NGSDSKGAEDDDSDSTSDTNNSDSNGNG---NN--- 532

Query: 154 IMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKST 213
                      G ++ + +         +    + +   D       S +  S     S 
Sbjct: 533 -----------GNDDNDKSD--------SGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD 573

Query: 214 HRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATG 273
                + D     S         + S  +D  +  D+  S  S D    K    K E+  
Sbjct: 574 SNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDS 633

Query: 274 PDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVS 333
            D + K   +       ++++         N     + +  +   +  +++  +D+ D S
Sbjct: 634 SDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSS 693

Query: 334 LVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAES 393
               S++   S++  +    + +     S N++    +       S       SSD+++S
Sbjct: 694 DSSNSSESSDSSDSSDSDSSDSS----DSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS 749

Query: 394 TNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDS 453
           +N ++   +   S       S+ +  + +      S   S           ++  N  DS
Sbjct: 750 SNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809

Query: 454 FNGP-SHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSE 512
            +   S ++  ++           ++S  +        S G    S+ R  S    DSS+
Sbjct: 810 SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869

Query: 513 SSDSGSSSES 522
           SSDS +SS+S
Sbjct: 870 SSDSSNSSDS 879



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 67/356 (18%), Positives = 116/356 (32%), Gaps = 20/356 (5%)

Query: 182 ASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQH-NIDYLKHLSKVKKIPSDFEGSG 240
           +S + + +   D K    DS +  S   S S+      N       S      S  + S 
Sbjct: 626 SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSN 685

Query: 241 YTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTK- 299
            +D  +  D+  S  S D     D      +   +    D  +  +  S   S   D+  
Sbjct: 686 SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSD 745

Query: 300 -KPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRV 358
                N     + +  +      +++  +D+ D S    SND   S++  +      +  
Sbjct: 746 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSN 805

Query: 359 DAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQ 418
            + S ++             S       SSD+++S+N ++   +   S     D SNR+ 
Sbjct: 806 SSDSSDSSDSS-----DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD 860

Query: 419 ATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNN 478
           ++ N      S   S           NE  N  DS +  +  +  +            +N
Sbjct: 861 SS-NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN 919

Query: 479 STRNKGMPQGKGSWGRQPHSNRRFSSRRRD-----------DSSESSDSGSSSESD 523
           S+ +        +      SN   SS   D           DSS SSDS  S+ SD
Sbjct: 920 SSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSD 975



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 48/286 (16%), Positives = 101/286 (35%), Gaps = 3/286 (1%)

Query: 238 GSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLD 297
           G G +D  +   +D S  S D     D       +  D +  D  +  +  S++  +   
Sbjct: 543 GKGKSDSSDSDSSDSSN-SSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNS 601

Query: 298 TKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNR 357
           +     ++  +  ++  ++    D +  E+D+ D      S+D   S +       + + 
Sbjct: 602 SDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSN 661

Query: 358 VDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRN 417
               S ++     +     + S       SSD+++S+N +E   +   S     D S+ +
Sbjct: 662 SSNSSDSSDSS--DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSS 719

Query: 418 QATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQN 477
            +  ++     S   S           ++  N  DS +     N               +
Sbjct: 720 NSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDS 779

Query: 478 NSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESD 523
           +++ +              +S+   +S    DSS+SSDS SS+ SD
Sbjct: 780 SNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD 825



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 54/290 (18%), Positives = 102/290 (35%), Gaps = 17/290 (5%)

Query: 234 SDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAES 293
           SD + S  +D  +  ++  S  S D     D     +++          +  +  S   S
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783

Query: 294 THLDTKKPGYNEIPEREENGGNTIGTRDET-AKEADAVDVSLVEGSNDIMGSTNFKELPG 352
              D+     +       +  N+  + D + + ++D+ + S    S+D   S+N  +   
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSD--S 841

Query: 353 REGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVD 412
            + +    GS +    + +       S       SSD+++S++ NE   +   S     D
Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSS-----D 896

Query: 413 HSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYV 472
            SN + +  ++     S   S      +    +E  N  D+ N     N           
Sbjct: 897 SSNSSDSDSSD-----SSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDS---- 947

Query: 473 PHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSES 522
               N+S  +        S     +S+    S    DSS+SSDS  SS+S
Sbjct: 948 SDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 80/466 (17%), Positives = 155/466 (33%), Gaps = 32/466 (6%)

Query: 59   SSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYP 118
            SS  +   + K D S SE+  +   SKS +  +N    +     S+  N+ N    S   
Sbjct: 613  SSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSS 672

Query: 119  KSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLN 178
             S+ +    D  ++       +   ++   ++         +       N  ++  +  N
Sbjct: 673  DSSDSSSSSDSSNSSDSSDSSDSSNSS--ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSN 730

Query: 179  IIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEG 238
               +S +   + S D       S +  S   S S              S         + 
Sbjct: 731  SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNS--------------SDSSDSSDSSDS 776

Query: 239  SGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDT 298
            S  ++  +  D+  S  S D     D     +++          +  +  S +  +   +
Sbjct: 777  SDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSS 836

Query: 299  KKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRV 358
                 ++  +  +   +    R +++  +D+ D S    S+D   S++       E +  
Sbjct: 837  NSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSD-----SNESSNS 891

Query: 359  DAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQ 418
               S +++    +       S       SSD++ES+N ++   N   S       S+ + 
Sbjct: 892  SDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD---NSNSSDSSNSSDSSDSS 948

Query: 419  ATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNN 478
             + N      S   S      S   D+   +  DS N  S ++  +            +N
Sbjct: 949  DSSNSSDSSNSSDSSNS----SDSSDSNSSDSSDSSN--SSDSSDSSDSSDSSDSSDSSN 1002

Query: 479  STRNKGMPQGKGSWGRQPHSNRRFSSRRRD--DSSESSDSGSSSES 522
            S+ +        S      SN   SS   D  DSS+SSDS  SS+S
Sbjct: 1003 SSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDS 1048



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 59/290 (20%), Positives = 106/290 (36%), Gaps = 16/290 (5%)

Query: 250 NDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGP-SEAESTHLDTKKPGYNEIPE 308
           N  S  + DG    D   K    G D    D   G     SE+++         YN    
Sbjct: 440 NTGSDSNSDGYDSYDFDDKS-MQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDES 498

Query: 309 REE-NGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGR-EGNRVDAGSQNAH 366
           ++  NG ++ G  D+ +      + S   G+ +     N K   G+ + +  D+ S ++ 
Sbjct: 499 KDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSS 558

Query: 367 QGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQR 426
                     + S +      SD+++S + +    +   S+    D S+ + ++ +    
Sbjct: 559 NSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSS-DSSDSSDSSDSSDSS 617

Query: 427 FPSKGKSQGLPIPSRGLDNEIKNEMD-------SFNGPSHENIITHGRKYHYVPHRQNNS 479
             S  KS      S   D++ K++         S N  S ++  +            ++S
Sbjct: 618 DSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDS 677

Query: 480 TRNKGMPQGKGSWGRQPHSNRRFSSRRRD----DSSESSDSGSSSESDGD 525
           + +        S      SN   SS   D    DSS+SSDS +S+ SD D
Sbjct: 678 SSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD 727



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 73/473 (15%), Positives = 155/473 (32%), Gaps = 26/473 (5%)

Query: 55   NQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRM 114
            N   SS  +   +       S++S++   S S +  +NR   +     S+  ++ N    
Sbjct: 822  NSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS--SNRSDSSNSSDSSDSSDSSNSSDS 879

Query: 115  SIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPR 174
            S    S  +    D  D+ S   D +   ++   ++        ++      +N  ++  
Sbjct: 880  SDSSDSNESSNSSDSSDS-SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDS 938

Query: 175  NVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPS 234
            +  N   +S +   ++S D       S +  S   + S      N       S       
Sbjct: 939  S--NSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD 996

Query: 235  DFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAEST 294
              + S  +D  +  D+  S  S D     D     +++    +  D          ++S+
Sbjct: 997  SSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS----DSSDSSDSSDSSDSSDSS 1052

Query: 295  HLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGRE 354
                     +     + +  +      ++++ +D+ D S    S+D   S++  +     
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1112

Query: 355  GNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHS 414
             +   + S N+           + S       SSD++ES++ ++   +   S       S
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDS-SDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171

Query: 415  NRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPH 474
            + +  + N      S   S           ++  +  DS +     +             
Sbjct: 1172 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD------------- 1218

Query: 475  RQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRD--DSSESSDSGSSSESDGD 525
              ++S+ +        S      S+   SS   D  DSS+SSDS S S  + D
Sbjct: 1219 -SSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESD 1270



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 67/450 (14%), Positives = 149/450 (33%), Gaps = 10/450 (2%)

Query: 75   SEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAIS 134
            S++S++  SS S N   +    + + S S+  N+ +    S    S+ +    D  D+ S
Sbjct: 792  SDSSDSSNSSDSSNSSDSSD--SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDS-S 848

Query: 135  KLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDK 194
               D +    +   N+        ++      ++ ++   +  +    S N + + S D 
Sbjct: 849  DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDS 908

Query: 195  KKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISP 254
                  S +  S   S+S++   ++       S      SD   S  +D     D+  S 
Sbjct: 909  SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS--SDSSNSSDSSNSS 966

Query: 255  FSGDGQPFKDIPGKGEATGPDL-EGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENG 313
             S D            +   D  +  D        + ++S+         N       + 
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD 1026

Query: 314  GNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFH 373
             +      +++  +D+ D S    S+D   S++  +      +  D+   +      +  
Sbjct: 1027 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD----SSDSSDSSDSSDSSDSSDSS 1082

Query: 374  YPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKS 433
                 S       SSD+++S++ ++   +   S      +S+ +  + +      S   S
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142

Query: 434  QGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWG 493
                       ++  +  DS +     +        +      ++ + +           
Sbjct: 1143 DSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1202

Query: 494  RQPHSNRRFSSRRRDDSSESSDSGSSSESD 523
                S+    S    DSS+SSDS  SS+S+
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSN 1232



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 61/464 (13%), Positives = 147/464 (31%), Gaps = 1/464 (0%)

Query: 59   SSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYP 118
            +S E+       D   S++S++  S+ S +  +N    +   + S+  ++ +    S   
Sbjct: 697  NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSS 756

Query: 119  KSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLN 178
             S+ +    D  D+       +   ++   ++        ++       + +++  +  +
Sbjct: 757  DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816

Query: 179  IIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEG 238
               +S +   ++S D       S +  S   S  +     N     + S           
Sbjct: 817  DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876

Query: 239  SGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDT 298
            S  +D  +  ++  S  S D     D      +   D       +  +  S +      +
Sbjct: 877  SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936

Query: 299  KKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRV 358
                 ++  +  ++  ++  +    +  +     S    S+D   S++  +      +  
Sbjct: 937  DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD 996

Query: 359  DAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQ 418
             + S N+           + S       SSD++ S++ ++   +   S       S+ + 
Sbjct: 997  SSDSSNSSDSSDSSDSSDS-SNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1055

Query: 419  ATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNN 478
             + +      S   S           +E  +  DS N     +               ++
Sbjct: 1056 NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115

Query: 479  STRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSES 522
             + +               S+   +S    DSSESSDS  SS+S
Sbjct: 1116 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDS 1159



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 62/450 (13%), Positives = 150/450 (33%), Gaps = 6/450 (1%)

Query: 75   SEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAIS 134
            S++S++  SS S +   +    +   S S+  ++ N    S    S+ +    D  D+ S
Sbjct: 756  SDSSDSSNSSDSSDSSDSSDSSDSSNS-SDSNDSSNSSDSSDSSNSSDSSNSSDSSDS-S 813

Query: 135  KLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDK 194
               D +   ++   N+        ++      ++ + +  +  N   +S +   + S D 
Sbjct: 814  DSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDS 873

Query: 195  KKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISP 254
                  S +  S   S S+     +       S         + S  +D  E  ++  + 
Sbjct: 874  SNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS 933

Query: 255  FSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGG 314
             S D     D     +++          +  +  S++  ++        N     + +  
Sbjct: 934  NSSDSSNSSDSSDSSDSSNSSDSSNSSDS--SNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991

Query: 315  NTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHY 374
            +      +++  +D+ D S    S++   S+N  +      +   + S ++         
Sbjct: 992  SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051

Query: 375  PPAPSKEKRKEGS--SDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGK 432
              + +     + S  SD+++S++ ++   + + S      +S+ +  + +      S   
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111

Query: 433  SQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSW 492
            S           ++  +  DS +     N               ++ + +          
Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171

Query: 493  GRQPHSNRRFSSRRRDDSSESSDSGSSSES 522
                 S+    S    DSS+SSDS  SS+S
Sbjct: 1172 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1201


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 103/543 (18%), Positives = 191/543 (35%), Gaps = 87/543 (16%)

Query: 24  TEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSEASENKGS 83
           T + K SC    R+      ++  HH  KR   + S  +  VQ     L+ S     +  
Sbjct: 472 TRRMKSSC---DRERSSRSSSLSSHHSSKR---DWSKSDKDVQS---SLTHSSRDSYRSK 522

Query: 84  SKSQNYFTNRQR---LNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQE 140
           S SQ+Y     R    +K  S S   +       S + K       +           + 
Sbjct: 523 SHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKT 582

Query: 141 EYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRD 200
           E   A +  N   ++ PV A         EN P     +IP S +   +  K  +KP + 
Sbjct: 583 EPLRATMAQNENVVVQPVVA---------ENIP-----VIPLSDSPPPSRWKPGQKPWKP 628

Query: 201 SQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQ 260
           S  +   +K+K+TH +     Y   L+ +K+  S    S Y   ++  ++D S +S    
Sbjct: 629 SYERIQEMKAKTTHLLPIQSTY--SLANIKETGS---SSSYHKREKNSESDQSTYSKYSD 683

Query: 261 PFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPG--------YNEIPEREEN 312
              +   +  +       +     +       S+H  ++ P         Y++  +   +
Sbjct: 684 RSSESSPRSRSRSS--RSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRS 741

Query: 313 GGNTIGTRDETAKEADAV-------DVSLVEGSNDIMGSTNFKELPGR----------EG 355
              T  + D+  +    +        VS  + S+    + + K + GR          E 
Sbjct: 742 SSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSES 801

Query: 356 NRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAA-----------ESTNYNEIPKNGK 404
                 S ++ Q  V+       ++EK K+G  +             +S +  E P + K
Sbjct: 802 RSSLDYSSDSEQSSVQ---ATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKK 858

Query: 405 GSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNE----MDSFNGPSHE 460
            + ++ +    RN +    K    SK  S+      R +    KN+     D   G +  
Sbjct: 859 RTLKENLSDHLRNGSKPKRKNYAGSKWDSES--NSERDVTKNSKNDSHPSSDKEEGEATS 916

Query: 461 NIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSS 520
           +  +   + H        S+ N  +P   G+W          SS++R  +S+S  S S+S
Sbjct: 917 DSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWK---------SSKQRTSTSDSEGSCSNS 967

Query: 521 ESD 523
           E++
Sbjct: 968 ENN 970



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 108/525 (20%), Positives = 190/525 (36%), Gaps = 93/525 (17%)

Query: 24   TEKTKQSCVEEQRQEEKN-KDNIGFH-----HLGKRINQELSSKENIVQERKKDLSLSEA 77
            T+K K+    ++ ++ K  K    FH       G+   +E+  K+ + QE K+     + 
Sbjct: 990  TKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQ-VTQESKE----KKV 1044

Query: 78   SENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAIS--- 134
            SEN  + K     T +   + E  +S K +T           S+    F   D  +S   
Sbjct: 1045 SENNETIKDNILKTEK---SSEEDLSGKHDT--------VTVSSDLDQFTKDDSKLSISP 1093

Query: 135  KLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDK 194
               + EE  A L   N+QH+              +E+ P  V +++    N  +  + D+
Sbjct: 1094 TALNTEENVACL--QNIQHV--------------EESVPNGVEDVLQTDDNM-EICTPDR 1136

Query: 195  KKPQRDSQAQKSPVKSKSTHRIQHNI----DYLKHLSKVKKIPSDFEGSGYTDLQERGDN 250
              P +  +   SP+ +        NI    D      + + +  +   S    L E G  
Sbjct: 1137 SSPAKVEET--SPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQ 1194

Query: 251  DISPFS----GDGQPFKDIPGKGEATGPDLEGKDIQT--GFAGPSEAESTHLDTKKPGYN 304
            D S  S    G+    K++  K +    D + K +Q     A P+ A S+ ++ K     
Sbjct: 1195 DSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKV--LT 1252

Query: 305  EIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQN 364
             +PE +  G      R E            ++  N +   + F E+  R+  R++   +N
Sbjct: 1253 TVPEMKPQG-----LRIE------------IKSKNKVRPGSLFDEV--RKTARLNRRPRN 1293

Query: 365  AHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEK 424
                  E      PS++   +  S +   +      ++   S       S    +T + +
Sbjct: 1294 QESSSDE----QTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYR 1349

Query: 425  QRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENII-THGRKYHYVPHRQNNS---- 479
             R  S+ +S+G    SRG      +   S+   SH     +  R   Y PH ++ S    
Sbjct: 1350 SRSYSRSRSRGWY--SRGRTRSRSSSYRSYK--SHRTSSRSRSRSSSYDPHSRSRSYTYD 1405

Query: 480  -----TRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSS 519
                 +R++   Q   S+ R    NRR  S R   S   SD   S
Sbjct: 1406 SYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYS 1450


>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
           precursor [Homo sapiens]
          Length = 513

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 95/478 (19%), Positives = 181/478 (37%), Gaps = 46/478 (9%)

Query: 61  KENIVQERKKDLSLSEASE-NKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPK 119
           K ++ Q     L  SE+SE +K SS+ Q           E  + + ++ +       + +
Sbjct: 34  KGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSR 93

Query: 120 STGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTA-----IKLLGEENKENTPR 174
           STG KG +D DD      D+++ G     ++     GP         +L  +E+ ++T +
Sbjct: 94  STG-KGGDDKDD------DEDDSGDDTFGDDDSG-PGPKDRQEGGNSRLGSDEDSDDTIQ 145

Query: 175 NVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPS 234
                 P   + A+  + + ++   + +    P    ST   +    ++   S  +    
Sbjct: 146 ASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHG 205

Query: 235 DFEGSGYTDLQERGDNDISPFSGDGQPFKDIPG-KGEATGPDLEGKDIQTGFAGPSEAES 293
           D  GS   D   + D+  S  S  G    +  G K + +G + E  + Q           
Sbjct: 206 D--GSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 263

Query: 294 THLDTKKPGYNEIPEREE-NGGNTIG-TRDETAKEADAVDVSLVEGSNDIMGST---NFK 348
           +    +K   +E  +R E +  NT+   + ++ + +++ D  L +   D  G +   + +
Sbjct: 264 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 323

Query: 349 ELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDA-AESTNYNEIPKNGKGST 407
            L   E   VD  S  + Q           S+E   E   +  +ES   N  P       
Sbjct: 324 NLSQEESQNVDGPSSESSQEA------NLSSQENSSESQEEVVSESRGDNPDPTTSYVED 377

Query: 408 RKGVDHSNRNQA-TLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHG 466
           ++  D S  + + TL+  +    + ++      S     E     +  N  S E + +H 
Sbjct: 378 QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS 437

Query: 467 RKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDG 524
                          +    Q + S   +  S+ + SSR ++DS+ S++S SSSE DG
Sbjct: 438 ---------------SSAESQSEESHSEEDDSDSQDSSRSKEDSN-STESKSSSEEDG 479


>gi|118600971 transcription elongation factor A (SII)-like 6 [Homo
           sapiens]
          Length = 183

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 39/133 (29%), Positives = 57/133 (42%), Gaps = 9/133 (6%)

Query: 299 KKPGYNEIPEREENGGNTIG-TRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNR 357
           +KP YN+     EN G        +   ++D  +    EG  +  G    +  PG EG  
Sbjct: 2   EKP-YNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDAEGKTECEGKRKAEGEPGDEGQL 60

Query: 358 VDAGSQNAHQGKVEFHYPP----APSKEKRKEGSSDAAESTNYNE-IPKNGKGSTRKGVD 412
            D GSQ   QGK E    P     P+ + + EG   AAE     + +P+  K  T +G D
Sbjct: 61  EDKGSQE-KQGKSEGEGKPQGEGKPASQAKPEGQPRAAEKRPAGDYVPRKAKRKTDRGTD 119

Query: 413 HSNR-NQATLNEK 424
            S + +Q  L E+
Sbjct: 120 DSPKDSQEDLQER 132


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 95/497 (19%), Positives = 167/497 (33%), Gaps = 51/497 (10%)

Query: 36   RQEEKNKDN-IGFHHLGKRINQELSSKENI--VQERKKDLSLSEASENKGSSKSQNYFTN 92
            RQ  K+K +  G  H G R ++  S  ++    Q  ++  S S  S ++GSS SQ+  + 
Sbjct: 1218 RQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSE 1277

Query: 93   RQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQ 152
            R   + E    +    H+G         + + GF   D A S  H  +       ++   
Sbjct: 1278 RHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRA-SHGHSADSSR----QSGTH 1332

Query: 153  HIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAH--SKDKKKPQRDSQAQKSPVKS 210
            H         +   E   ++P            +   H  S D  +       Q S    
Sbjct: 1333 HTESSSHGQAVSSHEQARSSPGE---------RHGSRHQQSADSSRHSGIGHRQASSAVR 1383

Query: 211  KSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGE 270
             S HR           S+V       E S    +   G       +G  Q       +G+
Sbjct: 1384 DSGHRGSSG-------SQVTNSEGHSEDSDTQSVSAHGQ------AGPHQQSHKESARGQ 1430

Query: 271  ATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAV 330
            +       +      +   ++ESTH  T             + G   G+R E A+ +   
Sbjct: 1431 SGESSGRSRSFLYQVSSHEQSESTHGQTAP-----------STGGRQGSRHEQARNSSRH 1479

Query: 331  DVSLVEGSNDIMGSTNFKELPGREGNRVDAG-SQNAHQGKVEFHYPPAPSKEKRKEGSSD 389
              S  +G + I G        GR+G+  +    ++ H G    H  P    +     S  
Sbjct: 1480 SASQ-DGQDTIRGHPGSSR-GGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGP 1537

Query: 390  AAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKN 449
             + S       ++G GS   G  H   +    + +     +G+S G    SR   + +  
Sbjct: 1538 RSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSK-TSRRQGSSVSQ 1596

Query: 450  EMDS-FNGPSHENIITHGRKYHYVPHRQ---NNSTRNKGMPQGKGSWGRQPHSNRRFSSR 505
            + DS  +    E       + HY   R+   + S   +   + + S G    S+R+  +R
Sbjct: 1597 DRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTR 1656

Query: 506  RRDDSSESSDSGSSSES 522
              + SS    + S  ++
Sbjct: 1657 HAETSSGGQAASSQEQA 1673



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 96/470 (20%), Positives = 172/470 (36%), Gaps = 82/470 (17%)

Query: 75   SEASENKGSSKSQNYFTNRQRLNKEYS-----------------ISNKENTHNGLRMSIY 117
            S+AS  +  S+S     +RQ  N E S                   +  ++ +G   S  
Sbjct: 3473 SDASRGQSGSRS----ASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAG 3528

Query: 118  PKSTGNKGFEDGDDAISKLH--DQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRN 175
            P+++ N+G     D+ S+ H  D E +  +  RN+               E++++ +   
Sbjct: 3529 PRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQ----------EQSRDGS--- 3575

Query: 176  VLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSD 235
                      +  +H +D+      +++ +       TH  +++       S  +   S 
Sbjct: 3576 ---------RHPTSHHEDRAGHGHSAESSRQ----SGTHHAENSSGGQAASSHEQARSSA 3622

Query: 236  FEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTH 295
             E  G +  Q+  D+      G GQ    +   G       +  D + G +  S+ +S  
Sbjct: 3623 GERHG-SHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSE-GHSEDSDTQSVS 3680

Query: 296  LDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREG 355
               +  G ++   +E   G + G    +   +    VS  E S    G        GR+G
Sbjct: 3681 AHGQA-GPHQQSHQESTRGRSAGRSGRSG--SFLYQVSTHEQSESAHGRAG-PSTGGRQG 3736

Query: 356  NRVD-AGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHS 414
            +R + A   + H    E          +   GS       +Y+E   +  G +  G  HS
Sbjct: 3737 SRHEQARDSSRHSASQE-----GQDTIRGHPGSRRGGRQGSYHEQSVDRSGHS--GSHHS 3789

Query: 415  NRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPH 474
            +    T ++ +   S G+S      SR    E +NE  S +G  H          H+   
Sbjct: 3790 H----TTSQGRSDASHGQSG-----SRSASRETRNEEQSGDGSRHSG------SRHHEAS 3834

Query: 475  RQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSES--SDSGSSSES 522
             Q +S+R+    QG+ +  R+  S R+ SS  +D  SE+   DS   SES
Sbjct: 3835 TQADSSRHSQSGQGESAGSRR--SRRQGSSVSQDSDSEAYPEDSERRSES 3882



 Score = 33.9 bits (76), Expect = 0.37
 Identities = 41/183 (22%), Positives = 68/183 (37%), Gaps = 13/183 (7%)

Query: 349  ELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTR 408
            E  GR G+ +   S   H+     H   APS   R+    D A+ ++ +   + G+ + R
Sbjct: 2082 ESSGRSGSFLYQVS--THEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIR 2139

Query: 409  KGVDHSNRNQATLNEKQRFPSKGKS---------QGLPIPSRGLDNEIKNEMDSFNGPSH 459
                 S   +   +++Q     G S         QG    SRG          +++    
Sbjct: 2140 GHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQS 2199

Query: 460  ENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSS 519
             +   H   +H+      +S+R+  + QG+ S  R   S  R SS  +D  SE     S 
Sbjct: 2200 GDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRT--SRPRGSSVSQDSDSEGHSEDSE 2257

Query: 520  SES 522
              S
Sbjct: 2258 RRS 2260



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 34/148 (22%), Positives = 57/148 (38%), Gaps = 7/148 (4%)

Query: 381  EKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQAT--LNEKQRFPSKGKSQGLPI 438
            E+ ++ S  +A     + I +   GS+R+G   S+  Q+           S   SQG   
Sbjct: 3416 EQARDSSRHSASQEGQDTI-RGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSD 3474

Query: 439  PSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHS 498
             SRG          + N     +   H   +H+    Q +S+R+    QG+ +  R   +
Sbjct: 3475 ASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRN 3534

Query: 499  NRRFSSRRRDDSSESSD----SGSSSES 522
                 S+  D    S D    SGS+S +
Sbjct: 3535 QGSSVSQDSDSQGHSEDSERWSGSASRN 3562



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 41/175 (23%), Positives = 61/175 (34%), Gaps = 30/175 (17%)

Query: 364 NAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGK-------GSTRKGVDHSNR 416
           + H+     H    PS   R+    + A   + +   ++G+       GS+R+G   S+ 
Sbjct: 798 STHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHH 857

Query: 417 NQAT--LNEKQRFPSKGKSQGLPIPSRG------LDNEIKNEMDSFNGPSHENIITHGRK 468
            Q+           S   SQG    SRG           +NE  S +G  H     H   
Sbjct: 858 EQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEAS 917

Query: 469 YHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESD 523
            H    R + +    G  Q +GS            + RR  SS S DS S   S+
Sbjct: 918 SHADISRHSQA----GQGQSEGS-----------RTSRRQGSSVSQDSDSEGHSE 957


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 45/220 (20%), Positives = 79/220 (35%), Gaps = 6/220 (2%)

Query: 245 QERGDNDISPFSGDGQPFKDIPGKGEATGPDLEG-KDIQTGFAGPSEAESTHLDTKKPGY 303
           +E G+ +      + +  K+  GK E  G ++EG ++ + G     E        ++ G 
Sbjct: 733 EEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD 792

Query: 304 NEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDA-GS 362
               E EE  G   G   E   E +  +V   +G  +        E    EG   +  G 
Sbjct: 793 QGEGEEEETEGR--GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGE 850

Query: 363 QNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGS--TRKGVDHSNRNQAT 420
           +   +GK E        +E+ +EG  +  E     E  + G+G     +G          
Sbjct: 851 EEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG 910

Query: 421 LNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHE 460
             E++    KG+ +G      G + E + E +   G   E
Sbjct: 911 EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEE 950



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 38/190 (20%), Positives = 68/190 (35%), Gaps = 5/190 (2%)

Query: 237  EGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHL 296
            EG G  + +E G+ +     G+G+  ++  G+GE    + EG++   G     E E    
Sbjct: 864  EGEGEEEGEE-GEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922

Query: 297  DTKKPGYNEIPEREENGGNTIGTRDETAKEAD-AVDVSLVEGSNDIMGSTNFKELPGREG 355
            +  + G  E  E E  G    G  +   +E +   +    EG  +  G    +E  G   
Sbjct: 923  EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982

Query: 356  NRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSN 415
                 G     +G+ E        +E   EG  +           + G+G   +G +   
Sbjct: 983  EEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEG---EGEEEEG 1039

Query: 416  RNQATLNEKQ 425
              +    EK+
Sbjct: 1040 EEEGEEREKE 1049


>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
          Length = 437

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 86/408 (21%), Positives = 144/408 (35%), Gaps = 38/408 (9%)

Query: 4   FCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFH-HLGKRINQELSSKE 62
           F V L+L +V  A       TE  KQ    E+     +  N+  H  L +R     S+K 
Sbjct: 3   FVVALVLLNVAAAGAVPLLATESVKQ----EEAGVRPSAGNVSTHPSLSQRPGG--STKS 56

Query: 63  NIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTG 122
           +   +  KD      S +K S+++Q       +   E       +  +G        ST 
Sbjct: 57  HPEPQTPKD------SPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTS 110

Query: 123 NKGFE--DGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNII 180
             G E     D+ SK H + +        +      P  +    G E K           
Sbjct: 111 KSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDS------ 164

Query: 181 PASMNYAKAHSKD-KKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGS 239
           P+        +KD   K   D Q  K    SKS    Q   D        K+ P D  GS
Sbjct: 165 PSKSGSEAQTTKDVPNKSGADGQTPKDG-SSKSGAEDQTPKDVPNKSGAEKQTPKD--GS 221

Query: 240 GYTDLQERGDNDISPFSG-DGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDT 298
             +  +E+G  D    SG + Q  KD P K     P    KD     + PS+ +    + 
Sbjct: 222 NKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSR--KDHSKPISNPSDNK----EL 275

Query: 299 KKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRV 358
            K   N++ ++ +   +   T  E+ +E D +         ++  S   +++  +E    
Sbjct: 276 PKADTNQLADKGKLSPHAFKT--ESGEETDLISPP----QEEVKSSEPTEDVEPKEAEDD 329

Query: 359 DAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGS 406
           D G +     K E       +  + +EG+   +  +  +++  NG G+
Sbjct: 330 DTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYPNGSGN 377


>gi|61175239 transcription elongation factor A (SII)-like 5 [Homo
           sapiens]
          Length = 206

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 37/128 (28%), Positives = 55/128 (42%), Gaps = 11/128 (8%)

Query: 307 PEREENGGNTIGTRDETAKE----ADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGS 362
           PE E N  +     DE + E    +D  +   +EG  +  G    +  PG EG   D G+
Sbjct: 12  PENERNLESEGKPEDEGSTEDEGKSDEEEKPDMEGKTECEGKREDEGEPGDEGQLEDEGN 71

Query: 363 QNAHQGKVEFHYPP----APSKEKRKEGSSDAAESTNYNE-IPKNGKGSTRKGVDHSNR- 416
           Q   QGK E    P     P+ + + E    AAE     + +P+  K  T +G D S + 
Sbjct: 72  QE-KQGKSEGEDKPQSEGKPASQAKPESQPRAAEKRPAEDYVPRKAKRKTDRGTDDSPKD 130

Query: 417 NQATLNEK 424
           +Q  L E+
Sbjct: 131 SQEDLQER 138


>gi|125656165 THO complex 2 [Homo sapiens]
          Length = 1593

 Score = 38.9 bits (89), Expect = 0.012
 Identities = 78/386 (20%), Positives = 144/386 (37%), Gaps = 33/386 (8%)

Query: 47   FHHLGKRINQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQR-------LNKE 99
            FHH        ++S +N         S+  AS++  SS  +    +R+R       +NK 
Sbjct: 1186 FHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETD-KSRERSQCGVKAVNKA 1244

Query: 100  YSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVT 159
             S + K N+ NG        S  NK  ++ D    K  ++E+            ++G   
Sbjct: 1245 SSTTPKGNSSNG-----NSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDG 1299

Query: 160  AIKLLGEE-NKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQH 218
              K   E  NK+   R      P S    +   K++K      +      +SKST   + 
Sbjct: 1300 KEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERER 1359

Query: 219  NIDYLKH--LSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPD- 275
              +  +   ++K  K   + +G   T +     + + P S   +P ++   +   T P  
Sbjct: 1360 EKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPV-PRSDIPEPEREQKRRKIDTHPSP 1418

Query: 276  LEGKDIQTGFAGPSEAEST-HLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSL 334
                 ++       E+ +  +++   P  ++  ERE +  +   +R+ + +     +   
Sbjct: 1419 SHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDR 1478

Query: 335  VEGSNDIMGSTNFKELPG------REGNRVDAGSQNAHQGKVEFHYPPAPSKEKR----- 383
             E   D   S N +E+P       +E N     S++  +   E  YP    KEK      
Sbjct: 1479 KERKRD--HSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSS 1536

Query: 384  -KEGSSDAAESTNYNEIPKNGKGSTR 408
             KE  SD+ +S   ++I   GK  +R
Sbjct: 1537 GKEKGSDSFKSEKMDKISSGGKKESR 1562


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 38.5 bits (88), Expect = 0.015
 Identities = 80/406 (19%), Positives = 160/406 (39%), Gaps = 61/406 (15%)

Query: 22  PQTEKTK---QSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSE-A 77
           P+++ +K   ++C ++ +++ KN        L  + N     K+++ + +  +  +SE  
Sbjct: 183 PESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNP----KKDLKRSKTSNDPISEIC 238

Query: 78  SENKGS-------SKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGD 130
           SEN  +        +S +   N     + YS +N +N    L+ + Y K    K  +   
Sbjct: 239 SENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNY--SLKYTKYTKKDTKKNAKKSS 296

Query: 131 DAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAH 190
           DA S+     +  +  ++ N++             +++K+   +       A    +K  
Sbjct: 297 DAESEDSKDAKKDSKKVKKNVK-------------KDDKKKDVKKDTESTDAESGDSKDE 343

Query: 191 SKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDN 250
            KD KK   D +  K   K K T +   + D     +K  +  S        +  ++ D 
Sbjct: 344 RKDTKK---DKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDA 400

Query: 251 DISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGF--AGPSEAESTHLDTKKPGYNEIPE 308
               FS D +   ++  K        + KD +T    +  ++ EST  D++  G ++  +
Sbjct: 401 KKITFSTDSE--SELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGK 458

Query: 309 REENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQG 368
           ++E  G     +D+  K+A   +    E  +D+    + K    ++G++ D         
Sbjct: 459 KDEKKGKKDSKKDDKKKDAKK-NAESTEMESDLELKKDKKHSKEKKGSKKDI-------- 509

Query: 369 KVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNG-KGSTR-KGVD 412
                      K+ RK+  S  AE   ++E  K G K ST+ KG D
Sbjct: 510 ----------KKDARKDTESTDAE---FDESSKTGFKTSTKIKGSD 542


>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform b [Homo sapiens]
          Length = 998

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 53/207 (25%), Positives = 76/207 (36%), Gaps = 19/207 (9%)

Query: 275 DLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPERE-------ENGGNTIGTRDETAKEA 327
           DL  K IQ+GF    E      +T K    E   +E       E  G    +  ET KEA
Sbjct: 322 DLNSK-IQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEA 380

Query: 328 DAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEK----- 382
           D    + V  SN    S+  +++P    N   A S       + F+ P  P  E      
Sbjct: 381 DKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGL-FNKPEEPKDESPSSWR 439

Query: 383 ---RKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIP 439
              RK GS +       +  P   +GS+      S R  A L+ K +   + KS    + 
Sbjct: 440 LGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDK-ERENKSYISSLA 498

Query: 440 SRGLDNEIKNEMDSFNGPSHENIITHG 466
            R L N   +  +  N  S  N++  G
Sbjct: 499 PRKL-NSTSDIEEKENRESAVNLVRSG 524


>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform a [Homo sapiens]
          Length = 982

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 53/207 (25%), Positives = 76/207 (36%), Gaps = 19/207 (9%)

Query: 275 DLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPERE-------ENGGNTIGTRDETAKEA 327
           DL  K IQ+GF    E      +T K    E   +E       E  G    +  ET KEA
Sbjct: 322 DLNSK-IQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEA 380

Query: 328 DAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEK----- 382
           D    + V  SN    S+  +++P    N   A S       + F+ P  P  E      
Sbjct: 381 DKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGL-FNKPEEPKDESPSSWR 439

Query: 383 ---RKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIP 439
              RK GS +       +  P   +GS+      S R  A L+ K +   + KS    + 
Sbjct: 440 LGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDK-ERENKSYISSLA 498

Query: 440 SRGLDNEIKNEMDSFNGPSHENIITHG 466
            R L N   +  +  N  S  N++  G
Sbjct: 499 PRKL-NSTSDIEEKENRESAVNLVRSG 524


>gi|55749431 transcription elongation factor A (SII)-like 3 [Homo
           sapiens]
          Length = 200

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 9/133 (6%)

Query: 299 KKPGYNEIPEREENGGNTIG-TRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNR 357
           +KP YN+     EN G        +   ++D  +   VEG  +  G    +  PG EG  
Sbjct: 2   EKP-YNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGDEGQL 60

Query: 358 VDAGSQNAHQGKVEFHYPP----APSKEKRKEGSSDAAESTNYNE-IPKNGKGSTRKGVD 412
            D GSQ   QG+ E    P     P+ + + E    AAE     + +P+  K  T +G D
Sbjct: 61  EDEGSQE-KQGRSEGEGKPQGEGKPASQAKPESQPRAAEKRPAEDYVPRKAKRKTDRGTD 119

Query: 413 HSNR-NQATLNEK 424
            S + +Q  L E+
Sbjct: 120 DSPKDSQEDLQER 132


>gi|14249718 transcription elongation factor A (SII)-like 3 [Homo
           sapiens]
          Length = 200

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 9/133 (6%)

Query: 299 KKPGYNEIPEREENGGNTIG-TRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNR 357
           +KP YN+     EN G        +   ++D  +   VEG  +  G    +  PG EG  
Sbjct: 2   EKP-YNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGDEGQL 60

Query: 358 VDAGSQNAHQGKVEFHYPP----APSKEKRKEGSSDAAESTNYNE-IPKNGKGSTRKGVD 412
            D GSQ   QG+ E    P     P+ + + E    AAE     + +P+  K  T +G D
Sbjct: 61  EDEGSQE-KQGRSEGEGKPQGEGKPASQAKPESQPRAAEKRPAEDYVPRKAKRKTDRGTD 119

Query: 413 HSNR-NQATLNEK 424
            S + +Q  L E+
Sbjct: 120 DSPKDSQEDLQER 132


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 37.0 bits (84), Expect = 0.044
 Identities = 64/307 (20%), Positives = 107/307 (34%), Gaps = 51/307 (16%)

Query: 239 SGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDT 298
           S  TD++ +    I        P K  PGKG    P            G + A ++    
Sbjct: 207 SDETDVEVKASEKILQVRAASAPAKGTPGKGATPAP-----------PGKAGAVASQTKA 255

Query: 299 KKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRV 358
            KP      E  E+        +E    A A+  +   G    +G+ +    P +E  R 
Sbjct: 256 GKP-----EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAAS---APAKESPR- 306

Query: 359 DAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQ 418
             G+  A  GK       A + ++ ++  S + ES +  E P   K S +     + + +
Sbjct: 307 -KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK-----APQVR 360

Query: 419 ATLNEKQRFPSKGKSQGLP----------------IPSRGLDNEIKNEMDSFNGPSHENI 462
           A     +  P KG +   P                  SR    E  ++ ++    +   +
Sbjct: 361 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 420

Query: 463 ITHGRKYHYVPHRQNNSTRNKGMPQGKGSW----GRQPHSNRRFSSRRRDDSSESSDSGS 518
              G+     P  +  ST   G P GKG+     G+   +       + ++ SESS   S
Sbjct: 421 KPLGKS----PQVKPASTMGMG-PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEES 475

Query: 519 SSESDGD 525
           S  SDG+
Sbjct: 476 SDSSDGE 482


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 37.0 bits (84), Expect = 0.044
 Identities = 64/307 (20%), Positives = 107/307 (34%), Gaps = 51/307 (16%)

Query: 239 SGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDT 298
           S  TD++ +    I        P K  PGKG    P            G + A ++    
Sbjct: 207 SDETDVEVKASEKILQVRAASAPAKGTPGKGATPAP-----------PGKAGAVASQTKA 255

Query: 299 KKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRV 358
            KP      E  E+        +E    A A+  +   G    +G+ +    P +E  R 
Sbjct: 256 GKP-----EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAAS---APAKESPR- 306

Query: 359 DAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQ 418
             G+  A  GK       A + ++ ++  S + ES +  E P   K S +     + + +
Sbjct: 307 -KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK-----APQVR 360

Query: 419 ATLNEKQRFPSKGKSQGLP----------------IPSRGLDNEIKNEMDSFNGPSHENI 462
           A     +  P KG +   P                  SR    E  ++ ++    +   +
Sbjct: 361 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 420

Query: 463 ITHGRKYHYVPHRQNNSTRNKGMPQGKGSW----GRQPHSNRRFSSRRRDDSSESSDSGS 518
              G+     P  +  ST   G P GKG+     G+   +       + ++ SESS   S
Sbjct: 421 KPLGKS----PQVKPASTMGMG-PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEES 475

Query: 519 SSESDGD 525
           S  SDG+
Sbjct: 476 SDSSDGE 482


>gi|226423889 myocardin isoform 1 [Homo sapiens]
          Length = 986

 Score = 36.6 bits (83), Expect = 0.058
 Identities = 35/134 (26%), Positives = 57/134 (42%), Gaps = 12/134 (8%)

Query: 279 KDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGS 338
           K  Q  F+  ++A +   D+   G +    R E+  N+ G+  + AK +D      + G+
Sbjct: 138 KGNQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPD-AKASDTPSTGSL-GT 195

Query: 339 NDIMGSTNFKELPGREGNRVDAGSQNAHQ---GKVEFHYPPAPSKEKRKEGSSDAAESTN 395
           N  + S       G E +R D+ SQ +HQ   GK     P  P        S    +S N
Sbjct: 196 NQDLAS-------GSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKSLGDSKN 248

Query: 396 YNEIPKNGKGSTRK 409
            ++ PK+ K   +K
Sbjct: 249 RHKKPKDPKPKVKK 262


>gi|23957692 myocardin isoform 2 [Homo sapiens]
          Length = 938

 Score = 36.6 bits (83), Expect = 0.058
 Identities = 35/134 (26%), Positives = 57/134 (42%), Gaps = 12/134 (8%)

Query: 279 KDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGS 338
           K  Q  F+  ++A +   D+   G +    R E+  N+ G+  + AK +D      + G+
Sbjct: 138 KGNQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPD-AKASDTPSTGSL-GT 195

Query: 339 NDIMGSTNFKELPGREGNRVDAGSQNAHQ---GKVEFHYPPAPSKEKRKEGSSDAAESTN 395
           N  + S       G E +R D+ SQ +HQ   GK     P  P        S    +S N
Sbjct: 196 NQDLAS-------GSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKSLGDSKN 248

Query: 396 YNEIPKNGKGSTRK 409
            ++ PK+ K   +K
Sbjct: 249 RHKKPKDPKPKVKK 262


>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
           precursor [Homo sapiens]
          Length = 497

 Score = 36.6 bits (83), Expect = 0.058
 Identities = 71/371 (19%), Positives = 139/371 (37%), Gaps = 32/371 (8%)

Query: 162 KLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNID 221
           +L  +E+ ++T +      P   + A+  + + ++   + +    P    ST   +    
Sbjct: 117 RLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEH 176

Query: 222 YLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPG-KGEATGPDLEGKD 280
           ++   S  +    D  GS   D   + D+  S  S  G    +  G K + +G + E  +
Sbjct: 177 WVGGGSDGESSHGD--GSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQAN 234

Query: 281 IQTGFAGPSEAESTHLDTKKPGYNEIPEREE-NGGNTIG-TRDETAKEADAVDVSLVEGS 338
            Q           +    +K   +E  +R E +  NT+   + ++ + +++ D  L +  
Sbjct: 235 TQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPR 294

Query: 339 NDIMGST---NFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDA-AEST 394
            D  G +   + + L   E   VD  S  + Q           S+E   E   +  +ES 
Sbjct: 295 RDSKGDSQEDSKENLSQEESQNVDGPSSESSQEA------NLSSQENSSESQEEVVSESR 348

Query: 395 NYNEIPKNGKGSTRKGVDHSNRNQA-TLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDS 453
             N  P       ++  D S  + + TL+  +    + ++      S     E     + 
Sbjct: 349 GDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPED 408

Query: 454 FNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSES 513
            N  S E + +H                +    Q + S   +  S+ + SSR ++DS+ S
Sbjct: 409 ENSSSQEGLQSHS---------------SSAESQSEESHSEEDDSDSQDSSRSKEDSN-S 452

Query: 514 SDSGSSSESDG 524
           ++S SSSE DG
Sbjct: 453 TESKSSSEEDG 463



 Score = 30.0 bits (66), Expect = 5.4
 Identities = 24/123 (19%), Positives = 56/123 (45%), Gaps = 8/123 (6%)

Query: 22  PQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDL---SLSEAS 78
           P  +  ++S + E+    +  DN     +     +  +S++  + + ++D    S  ++ 
Sbjct: 247 PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK 306

Query: 79  ENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHD 138
           EN    +SQN        ++E ++S++EN+    +  +  +S G    ++ D   S + D
Sbjct: 307 ENLSQEESQNVDGPSSESSQEANLSSQENSSES-QEEVVSESRG----DNPDPTTSYVED 361

Query: 139 QEE 141
           QE+
Sbjct: 362 QED 364


>gi|226423891 myocardin isoform 3 [Homo sapiens]
          Length = 684

 Score = 36.6 bits (83), Expect = 0.058
 Identities = 35/134 (26%), Positives = 57/134 (42%), Gaps = 12/134 (8%)

Query: 279 KDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGS 338
           K  Q  F+  ++A +   D+   G +    R E+  N+ G+  + AK +D      + G+
Sbjct: 42  KGNQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPD-AKASDTPSTGSL-GT 99

Query: 339 NDIMGSTNFKELPGREGNRVDAGSQNAHQ---GKVEFHYPPAPSKEKRKEGSSDAAESTN 395
           N  + S       G E +R D+ SQ +HQ   GK     P  P        S    +S N
Sbjct: 100 NQDLAS-------GSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVKSKSLGDSKN 152

Query: 396 YNEIPKNGKGSTRK 409
            ++ PK+ K   +K
Sbjct: 153 RHKKPKDPKPKVKK 166


>gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo
           sapiens]
          Length = 1045

 Score = 36.2 bits (82), Expect = 0.075
 Identities = 38/177 (21%), Positives = 66/177 (37%), Gaps = 14/177 (7%)

Query: 357 RVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNR 416
           R +A  +N H  +  ++Y    S+      S  A+  T+     K G G  +    H   
Sbjct: 747 RTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPG-GKRKYKTRHLEG 805

Query: 417 NQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSF-NGPSHENIITHGRKYHYVPHR 475
                   + F SK K       S  LD   KNE D+F +  S +    H R+      R
Sbjct: 806 TNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRR-----KR 860

Query: 476 QNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSS-------SESDGD 525
           +  S   + + +GK +   + H  ++   +++       ++  S       S+SD D
Sbjct: 861 KTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKD 917


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 36.2 bits (82), Expect = 0.075
 Identities = 74/373 (19%), Positives = 127/373 (34%), Gaps = 75/373 (20%)

Query: 173 PRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKI 232
           P  V ++ P     A   +K  KKP+ +S++ +   +S+                     
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE-------------------- 281

Query: 233 PSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAE 292
               E    T  Q +    I        P K  PGKG    P            G + A 
Sbjct: 282 ----EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-----------GKAGAV 326

Query: 293 STHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPG 352
           ++     KP  +     EE+  +     +E    A A+  +   G    +G+ +    P 
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDS-----EEETPAAKALLQAKASGKTSQVGAAS---APA 378

Query: 353 REGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVD 412
           +E  R   G+  A  GK       A + ++ ++  S + ES +  E P   K S +    
Sbjct: 379 KESPR--KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK---- 432

Query: 413 HSNRNQATLNEKQRFPSKGKSQGLPIP----------------SRGLDNEIKNEMDSFNG 456
            + + +A     +  P KG +   P                  SR    E  ++ ++   
Sbjct: 433 -APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 457 PSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSW----GRQPHSNRRFSSRRRDDSSE 512
            +   +   G+     P  +  ST   G P GKG+     G+   +       + ++ SE
Sbjct: 492 MNAAQVKPLGKS----PQVKPASTMGMG-PLGKGAGPVPPGKVGPATPSAQVGKWEEDSE 546

Query: 513 SSDSGSSSESDGD 525
           SS   SS  SDG+
Sbjct: 547 SSSEESSDSSDGE 559


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 36.2 bits (82), Expect = 0.075
 Identities = 74/373 (19%), Positives = 127/373 (34%), Gaps = 75/373 (20%)

Query: 173 PRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKI 232
           P  V ++ P     A   +K  KKP+ +S++ +   +S+                     
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE-------------------- 281

Query: 233 PSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAE 292
               E    T  Q +    I        P K  PGKG    P            G + A 
Sbjct: 282 ----EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-----------GKAGAV 326

Query: 293 STHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPG 352
           ++     KP  +     EE+  +     +E    A A+  +   G    +G+ +    P 
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDS-----EEETPAAKALLQAKASGKTSQVGAAS---APA 378

Query: 353 REGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVD 412
           +E  R   G+  A  GK       A + ++ ++  S + ES +  E P   K S +    
Sbjct: 379 KESPR--KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK---- 432

Query: 413 HSNRNQATLNEKQRFPSKGKSQGLPIP----------------SRGLDNEIKNEMDSFNG 456
            + + +A     +  P KG +   P                  SR    E  ++ ++   
Sbjct: 433 -APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 457 PSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSW----GRQPHSNRRFSSRRRDDSSE 512
            +   +   G+     P  +  ST   G P GKG+     G+   +       + ++ SE
Sbjct: 492 MNAAQVKPLGKS----PQVKPASTMGMG-PLGKGAGPVPPGKVGPATPSAQVGKWEEDSE 546

Query: 513 SSDSGSSSESDGD 525
           SS   SS  SDG+
Sbjct: 547 SSSEESSDSSDGE 559


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 36.2 bits (82), Expect = 0.075
 Identities = 74/373 (19%), Positives = 127/373 (34%), Gaps = 75/373 (20%)

Query: 173 PRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKI 232
           P  V ++ P     A   +K  KKP+ +S++ +   +S+                     
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE-------------------- 281

Query: 233 PSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAE 292
               E    T  Q +    I        P K  PGKG    P            G + A 
Sbjct: 282 ----EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-----------GKAGAV 326

Query: 293 STHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPG 352
           ++     KP  +     EE+  +     +E    A A+  +   G    +G+ +    P 
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDS-----EEETPAAKALLQAKASGKTSQVGAAS---APA 378

Query: 353 REGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVD 412
           +E  R   G+  A  GK       A + ++ ++  S + ES +  E P   K S +    
Sbjct: 379 KESPR--KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK---- 432

Query: 413 HSNRNQATLNEKQRFPSKGKSQGLPIP----------------SRGLDNEIKNEMDSFNG 456
            + + +A     +  P KG +   P                  SR    E  ++ ++   
Sbjct: 433 -APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 457 PSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSW----GRQPHSNRRFSSRRRDDSSE 512
            +   +   G+     P  +  ST   G P GKG+     G+   +       + ++ SE
Sbjct: 492 MNAAQVKPLGKS----PQVKPASTMGMG-PLGKGAGPVPPGKVGPATPSAQVGKWEEDSE 546

Query: 513 SSDSGSSSESDGD 525
           SS   SS  SDG+
Sbjct: 547 SSSEESSDSSDGE 559


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 36.2 bits (82), Expect = 0.075
 Identities = 74/373 (19%), Positives = 127/373 (34%), Gaps = 75/373 (20%)

Query: 173 PRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKI 232
           P  V ++ P     A   +K  KKP+ +S++ +   +S+                     
Sbjct: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE-------------------- 281

Query: 233 PSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAE 292
               E    T  Q +    I        P K  PGKG    P            G + A 
Sbjct: 282 ----EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-----------GKAGAV 326

Query: 293 STHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPG 352
           ++     KP  +     EE+  +     +E    A A+  +   G    +G+ +    P 
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDS-----EEETPAAKALLQAKASGKTSQVGAAS---APA 378

Query: 353 REGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVD 412
           +E  R   G+  A  GK       A + ++ ++  S + ES +  E P   K S +    
Sbjct: 379 KESPR--KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK---- 432

Query: 413 HSNRNQATLNEKQRFPSKGKSQGLPIP----------------SRGLDNEIKNEMDSFNG 456
            + + +A     +  P KG +   P                  SR    E  ++ ++   
Sbjct: 433 -APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491

Query: 457 PSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSW----GRQPHSNRRFSSRRRDDSSE 512
            +   +   G+     P  +  ST   G P GKG+     G+   +       + ++ SE
Sbjct: 492 MNAAQVKPLGKS----PQVKPASTMGMG-PLGKGAGPVPPGKVGPATPSAQVGKWEEDSE 546

Query: 513 SSDSGSSSESDGD 525
           SS   SS  SDG+
Sbjct: 547 SSSEESSDSSDGE 559


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score = 36.2 bits (82), Expect = 0.075
 Identities = 39/174 (22%), Positives = 69/174 (39%), Gaps = 9/174 (5%)

Query: 353 REGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVD 412
           R GNR    S +  +GK+E       +K++ K  S    E T +    K  KG      +
Sbjct: 155 RNGNRSSTRSSST-KGKLELVDNKITTKKRSKSRSK---ERTRHRSDKKKSKGGIEIVKE 210

Query: 413 HSNRNQATLNEKQRFPSK-GKSQGLPIPSRG--LDNEIKNEMDSFNGPSHENIITHGRKY 469
            + R+++   +K + PSK  KSQ     S+   L    + ++     P+ + +    +  
Sbjct: 211 KTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSK 270

Query: 470 HYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESD 523
                R+ +   N+   + +G   R P   R  S  RR  S E     S ++ +
Sbjct: 271 S--KDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKE 322


>gi|47778921 alpha 1 type XIX collagen precursor [Homo sapiens]
          Length = 1142

 Score = 35.8 bits (81), Expect = 0.099
 Identities = 34/124 (27%), Positives = 45/124 (36%), Gaps = 4/124 (3%)

Query: 265 IPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETA 324
           IP KGEA  P   G   Q G  G       H     PG       E + G T G + E  
Sbjct: 288 IPNKGEAGLPGAPGSPGQKGHKGEPGENGLHGAPGFPGQKGEQGFEGSKGET-GEKGEQG 346

Query: 325 KEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQN--AHQGKVEFHYPPAPSKEK 382
           ++ D     L  G N + G       PG +G + D G     A  G +    P  P  ++
Sbjct: 347 EKGDPALAGL-NGENGLKGDLGPHGPPGPKGEKGDTGPPGPPALPGSLGIQGPQGPPGKE 405

Query: 383 RKEG 386
            + G
Sbjct: 406 GQRG 409


>gi|55749769 CWC22 spliceosome-associated protein homolog [Homo
           sapiens]
          Length = 908

 Score = 35.8 bits (81), Expect = 0.099
 Identities = 49/174 (28%), Positives = 71/174 (40%), Gaps = 30/174 (17%)

Query: 379 SKEKRKEGSSDAAESTNYNEIPKNGKGSTR-KGVDHSNRNQATLNEKQRFPSKGKSQGLP 437
           S E+    S  +  S + N++ K G G TR K VD   RNQ T + KQ+   +       
Sbjct: 697 SSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQET 756

Query: 438 IPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTR--------------NK 483
              R   +E   + +S +G +  + IT       VP  +NN +R              NK
Sbjct: 757 RTERERRSEKHRDQNS-SGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENK 815

Query: 484 -GMPQGKGSWGRQPHS-NRRFSSR-------RRDDSSESSD-----SGSSSESD 523
            G P+ K    R   S N + + R       RR D S+S +     SGS S+ D
Sbjct: 816 HGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDED 869


>gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
          Length = 1982

 Score = 35.4 bits (80), Expect = 0.13
 Identities = 60/302 (19%), Positives = 119/302 (39%), Gaps = 55/302 (18%)

Query: 16  AAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQ--------ELSSKENIVQE 67
           A+   Q   EK  +   + + +  K K N    + G+RIN         E S      Q 
Sbjct: 280 ASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQS 339

Query: 68  RKKDLSLSEASEN--------------------KGSSKSQNYFTNRQRLNKEYSISNKEN 107
            KK    SE S+N                    K   K Q+++   +R +  +S +    
Sbjct: 340 DKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITF 399

Query: 108 THNGLRMSIYPKSTGNKGFED--GDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLG 165
           +HN  +  +  +    +G+ED   D +++    Q+    + + N+  H    + + ++  
Sbjct: 400 SHNSSKYHLEER----RGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTH--KNIDSKEVDA 453

Query: 166 EENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKH 225
               ENTP          +   +  ++DK+K +++S+ +   ++++     +H     K 
Sbjct: 454 MHQWENTP----------LKAERHRTEDKRKREQESKEENRHIRNEKRVPTEH---LQKT 500

Query: 226 LSKVKKIPSDF--EGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQT 283
             + KK  +D   +    TD  E  DN +S    +G   K++  K E+   + + KD++ 
Sbjct: 501 NKETKKTTTDLKKQNEPKTDKGEVLDNGVS----EGADNKELAMKAESGPNETKNKDLKL 556

Query: 284 GF 285
            F
Sbjct: 557 SF 558


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.127    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,134,437
Number of Sequences: 37866
Number of extensions: 1140031
Number of successful extensions: 3281
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 2980
Number of HSP's gapped (non-prelim): 329
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.