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Search of human proteins with 94721263
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94721263 myotubularin related protein 12 [Homo sapiens]
(747 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94721263 myotubularin related protein 12 [Homo sapiens] 1539 0.0
gi|124028527 myotubularin related protein 10 [Homo sapiens] 437 e-122
gi|224994251 myotubularin related protein 11 isoform a [Homo sap... 223 5e-58
gi|89111941 myotubularin related protein 11 isoform b [Homo sapi... 209 6e-54
gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens] 144 4e-34
gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens] 144 4e-34
gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens] 144 4e-34
gi|4557896 myotubularin [Homo sapiens] 135 1e-31
gi|28872761 myotubularin-related protein 1 [Homo sapiens] 135 2e-31
gi|19923424 myotubularin related protein 9 [Homo sapiens] 127 4e-29
gi|21361759 myotubularin related protein 8 [Homo sapiens] 122 9e-28
gi|134142348 myotubularin related protein 6 [Homo sapiens] 118 2e-26
gi|225543474 myotubularin related protein 7 [Homo sapiens] 108 1e-23
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens] 108 2e-23
gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens] 108 2e-23
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens] 108 2e-23
gi|217272865 myotubularin related protein 4 [Homo sapiens] 103 8e-22
gi|29788755 SET binding factor 2 [Homo sapiens] 100 6e-21
gi|239735519 SET binding factor 1 [Homo sapiens] 89 2e-17
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 31 4.8
gi|55769583 progesterone-induced blocking factor 1 [Homo sapiens] 30 6.3
gi|4758650 kinesin family member 5C [Homo sapiens] 30 8.2
gi|34452713 Ca2+-dependent secretion activator isoform 2 [Homo s... 30 8.2
gi|34452715 Ca2+-dependent secretion activator isoform 1 [Homo s... 30 8.2
gi|34452711 Ca2+-dependent secretion activator isoform 3 [Homo s... 30 8.2
>gi|94721263 myotubularin related protein 12 [Homo sapiens]
Length = 747
Score = 1539 bits (3984), Expect = 0.0
Identities = 747/747 (100%), Positives = 747/747 (100%)
Query: 1 MLGKGVVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLK 60
MLGKGVVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLK
Sbjct: 1 MLGKGVVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLK 60
Query: 61 YVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGV 120
YVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGV
Sbjct: 61 YVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGV 120
Query: 121 FDEKKKTLFGQLKKYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKR 180
FDEKKKTLFGQLKKYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKR
Sbjct: 121 FDEKKKTLFGQLKKYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKR 180
Query: 181 LFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLP 240
LFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLP
Sbjct: 181 LFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLP 240
Query: 241 AYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGI 300
AYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGI
Sbjct: 241 AYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGI 300
Query: 301 YKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESS 360
YKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESS
Sbjct: 301 YKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESS 360
Query: 361 SWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQ 420
SWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQ
Sbjct: 361 SWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQ 420
Query: 421 SLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVL 480
SLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVL
Sbjct: 421 SLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVL 480
Query: 481 SDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPL 540
SDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPL
Sbjct: 481 SDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPL 540
Query: 541 YVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLIN 600
YVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLIN
Sbjct: 541 YVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLIN 600
Query: 601 SSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVAT 660
SSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVAT
Sbjct: 601 SSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVAT 660
Query: 661 LSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVL 720
LSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVL
Sbjct: 661 LSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVL 720
Query: 721 PTSGWKALGDEDDLAKREDEFVDLGDV 747
PTSGWKALGDEDDLAKREDEFVDLGDV
Sbjct: 721 PTSGWKALGDEDDLAKREDEFVDLGDV 747
>gi|124028527 myotubularin related protein 10 [Homo sapiens]
Length = 777
Score = 437 bits (1123), Expect = e-122
Identities = 265/718 (36%), Positives = 405/718 (56%), Gaps = 73/718 (10%)
Query: 14 KAPKPSFVSYVRPEEIHTNEKEVTE---KEVTLHLLPGEQLLCEASTVLKYVQEDSCQHG 70
K PKP+F SY+ P T++K +E K++ LLPGE ++ E + V K + D+ Q+
Sbjct: 5 KPPKPTFRSYLLPPP-QTDDKINSEPKIKKLEPVLLPGEIVVNEVNFVRKCIATDTSQYD 63
Query: 71 VYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGVFDEKKKT-LF 129
++G+L+C++FKI+F+ DD L + ++N ++GE+D+ L C++QI V D K+K +
Sbjct: 64 LWGKLICSNFKISFITDDPMPLQ--KFHYRNLLLGEHDVPLTCIEQIVTVNDHKRKQKVL 121
Query: 130 G---QLKKYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSY 186
G +LK P +LII+CKD R+ +F + E K++ I H++Q P L+ LF F Y
Sbjct: 122 GPNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQ-PTDLQLLFAFEY 180
Query: 187 ATAAQNNTVTD----------------------PKNHTVMFDTLKDWCWELERTKGNMKY 224
+N+ T +F+T DW E++RT G +
Sbjct: 181 VGKKYHNSANKINGIPSGDGGGGGGGGNGAGGGSSQKTPLFETYSDWDREIKRT-GASGW 239
Query: 225 KAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQ----GHGIPIWCWSCHNGSALLKMSA 280
+ S+NEGY + LP Y VVP+ L +++++ F G +P+WCWS NGSAL++M A
Sbjct: 240 RVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHSNGSALVRM-A 298
Query: 281 LPKEQDDGILQ---IQKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQL 337
L K+ +LQ I + + I K+ P V DL ++QE+Q A+ K KQL
Sbjct: 299 LIKD----VLQQRKIDQRICNAITKS--HPQRSDVYKSDLDKTLPNIQEVQAAFVKLKQL 352
Query: 338 FLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDL 397
+ + F +T+ KW S LE++ WL+ +R LK + E+ +E+++++V+L EE DL
Sbjct: 353 CV---NEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDL 409
Query: 398 CCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLD 457
C ++SLVQ+M+DP+ RT GFQSLIQKEWVM G+ FLDRCNHL++++KE P+FLLFLD
Sbjct: 410 SCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRSEKES-PLFLLFLD 468
Query: 458 CVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQK-----DTNMGREGQDTQ 512
WQL+ Q+P AFEF+ETYL VL DS I +F TF FNSPHQ+ + + + Q
Sbjct: 469 ATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTEFAISKNIQLGD 528
Query: 513 SKPLNLLTVWDWSVQFEPKAQTLLKNPLYVEK--PKLDKGQRKGMRFKHQRQLSLPLTQS 570
K L +VWDWS+QF K +TL NP Y+ K P + G K + + ++ S L
Sbjct: 529 EKGLKFPSVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQNGSVKSFK-RTKKSYSSTLRGM 587
Query: 571 KSSPKRGFFREETDHLIKNLLGKRISKLI-------NSSDELQDNFREFYDSWHSKSTDY 623
S+ K G ++ LL +R S ++ +D + +++ W SK +
Sbjct: 588 PSALKNGIISDQ------ELLPRRNSLILKPKPDPAQQTDSQNSDTEQYFREWFSKPANL 641
Query: 624 HGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATLSKLLEMMEEVQSLQEKIDER 681
HG++LP + G IK+W Y RW+PEAQI GG + KL + +EV L + ++
Sbjct: 642 HGVILPRVSGTHIKLWKLCYFRWVPEAQISLGGSITAFHKLSLLADEVDVLSRMLRQQ 699
>gi|224994251 myotubularin related protein 11 isoform a [Homo
sapiens]
Length = 709
Score = 223 bits (568), Expect = 5e-58
Identities = 198/689 (28%), Positives = 309/689 (44%), Gaps = 64/689 (9%)
Query: 46 LPGEQLLCEASTVLKYVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIG 105
LPGEQ+L A V K ++ + + G L+CT+F++ F N +T +
Sbjct: 46 LPGEQILAWAPGVRKGLEPE-----LSGTLICTNFRVTFQPCGWQW--NQDTPLNS---- 94
Query: 106 ENDITLHCVDQIYGVFDEKKKTLF--GQLKKY-PEKLIIHCKDLRVFQFCLRYTK-EEEV 161
E D L + ++ V + L G L K+ PE+++IH +D R+ + E +
Sbjct: 95 EYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQA 154
Query: 162 KRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGN 221
++ I+ ++ + + A Q + P + +T +DW E ER K
Sbjct: 155 FQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPP--IPLMETAEDW--ETERKKQA 210
Query: 222 MK-YKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGHGI----PIWCWSCHNGSALL 276
+ ++ +VNE + V LP YF VP + + V+R GH P W GS LL
Sbjct: 211 ARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLL 270
Query: 277 KMSALPKEQDDGILQIQKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQ 336
+ D I+ L + + + V D SL ++Q A+ + +
Sbjct: 271 RCGGFYTASDPNKEDIRAVEL------MLQAGHSDVVLVDTMDELPSLADVQLAHLRLRA 324
Query: 337 LFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASD 396
L L D+S + KW S LE + WLD +R CL+KA +I+ + ++ +V+L E D
Sbjct: 325 LCLPDSSV----AEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRD 380
Query: 397 LCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFL 456
L L+SSLVQL+ P RT GFQSL+Q+EWV GH FL R EE PVFLLFL
Sbjct: 381 LNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--GTGASEEAPVFLLFL 438
Query: 457 DCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQ---- 512
DCVWQL+ Q P FEF+E +L L DS+ +P TF N+P ++ G+ TQ
Sbjct: 439 DCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTP 498
Query: 513 --SKP-----LNL-LTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLS 564
S+P NL L+VWDW +++ +NP Y + D + Q
Sbjct: 499 GYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHCPDSWLP-----RPQPSFM 553
Query: 565 LP--------LTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSW 616
+P ++ +P + + + + + SS+ L D W
Sbjct: 554 VPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPSHW 613
Query: 617 HSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVATLSKLLEMMEEVQSLQE 676
+ GLLLP GP+I++W + YLR PE Q+ G T+S L + + +Q L
Sbjct: 614 GACPLP-PGLLLPGYLGPQIRLWRRCYLRGRPEVQM--GLSAPTISGLQDELSHLQELLR 670
Query: 677 KIDERHHSQQAPQAEAPCLLRNSARLSSL 705
K R + + P + N ++ +
Sbjct: 671 KWTPRISPEDHSKKRDPHTILNPTEIAGI 699
>gi|89111941 myotubularin related protein 11 isoform b [Homo
sapiens]
Length = 640
Score = 209 bits (533), Expect = 6e-54
Identities = 176/603 (29%), Positives = 272/603 (45%), Gaps = 51/603 (8%)
Query: 130 GQLKKY-PEKLIIHCKDLRVFQFCLRYTK-EEEVKRIVSGIIHHTQAPKLLKRLFLFSYA 187
G L K+ PE+++IH +D R+ + E + ++ I+ ++ + +
Sbjct: 49 GSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLS 108
Query: 188 TAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK-YKAVSVNEGYKVCERLPAYFVVP 246
A Q + P + +T +DW E ER K + ++ +VNE + V LP YF VP
Sbjct: 109 KAGQGSGSRKPP--IPLMETAEDW--ETERKKQAARGWRVSTVNERFDVATSLPRYFWVP 164
Query: 247 TPLPEENVQRFQGHGI----PIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGIYK 302
+ + V+R GH P W GS LL+ D I+ L
Sbjct: 165 NRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVEL----- 219
Query: 303 TIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSW 362
+ + + V D SL ++Q A+ + + L L D+S + KW S LE + W
Sbjct: 220 -MLQAGHSDVVLVDTMDELPSLADVQLAHLRLRALCLPDSSV----AEDKWLSALEGTRW 274
Query: 363 LDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSL 422
LD +R CL+KA +I+ + ++ +V+L E DL L+SSLVQL+ P RT GFQSL
Sbjct: 275 LDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSL 334
Query: 423 IQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSD 482
+Q+EWV GH FL R EE PVFLLFLDCVWQL+ Q P FEF+E +L L D
Sbjct: 335 VQREWVAAGHPFLTRLG--GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHD 392
Query: 483 SLYIPIFSTFFFNSPHQKDTNMGREGQDTQ------SKP-----LNL-LTVWDWSVQFEP 530
S+ +P TF N+P ++ G+ TQ S+P NL L+VWDW +++
Sbjct: 393 SVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSN 452
Query: 531 KAQTLLKNPLYVEKPKLDKGQRKGMRFKHQRQLSLP--------LTQSKSSPKRGFFREE 582
+NP Y + D + Q +P ++ +P
Sbjct: 453 AQILQFQNPGYDPEHCPDSWLP-----RPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWR 507
Query: 583 TDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQR 642
+ + + + + SS+ L D W + GLLLP GP+I++W +
Sbjct: 508 DSPSLLAVSSRWLPRPAISSESLADQEWGLPSHWGACPLP-PGLLLPGYLGPQIRLWRRC 566
Query: 643 YLRWIPEAQILGGGQVATLSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARL 702
YLR PE Q+ G T+S L + + +Q L K R + + P + N +
Sbjct: 567 YLRGRPEVQM--GLSAPTISGLQDELSHLQELLRKWTPRISPEDHSKKRDPHTILNPTEI 624
Query: 703 SSL 705
+ +
Sbjct: 625 AGI 627
>gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]
Length = 643
Score = 144 bits (362), Expect = 4e-34
Identities = 126/435 (28%), Positives = 196/435 (45%), Gaps = 69/435 (15%)
Query: 143 CKDLRVFQFCLRYTKEEEVKR-IVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNH 201
CKD+R +F + E +R I ++ + LF F Y P+N
Sbjct: 155 CKDIRNLRFA--HKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVF-------PENG 205
Query: 202 TVMFDTLKDWCWELERTKG--NMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR--- 256
++D L ++ R +G N ++ +NE Y++C+ PA VVP +P+E ++R
Sbjct: 206 WKLYDPLLEY-----RRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVAS 260
Query: 257 FQGHG-IPIWCWSCHNGSALLKMSALP---------KEQDDGILQIQKSFLDG--IYKTI 304
F+ G IP+ W A + + P KE + + I S I+
Sbjct: 261 FRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFD 320
Query: 305 HRPPYEIV---------KTEDLSSN----FLSLQEIQTAYSKFKQL--FLIDNSTEFWDT 349
RP V ++ED N FL + I ++L + N E
Sbjct: 321 ARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEE---- 376
Query: 350 DIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMM 409
W S LES+ WL+ I+ L A+ I + +E+ +V++ + D ++SL LM+
Sbjct: 377 -THWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLML 435
Query: 410 DPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQN--DKEEVPVFLLFLDCVWQLVHQHP 467
D + RT GF+ L++KEW+ GH F R H +N D + PVFL F+DCVWQ+ Q P
Sbjct: 436 DGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFP 495
Query: 468 PAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDW-SV 526
AFEF E +L + D LY +F TF NS Q+ G+E + P +++W + +
Sbjct: 496 TAFEFNEYFLITILDHLYSCLFGTFLCNSEQQR----GKE-----NLPKRTVSLWSYINS 546
Query: 527 QFEPKAQTLLKNPLY 541
Q E NPLY
Sbjct: 547 QLED-----FTNPLY 556
Score = 31.6 bits (70), Expect = 2.8
Identities = 25/112 (22%), Positives = 49/112 (43%), Gaps = 10/112 (8%)
Query: 588 KNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWI 647
+NL + +S + +L+D Y S+ + +L P +++W Y+RW
Sbjct: 531 ENLPKRTVSLWSYINSQLEDFTNPLYGSYSNH------VLYPVASMRHLELWVGYYIRWN 584
Query: 648 PE---AQILGGGQVATLSKLLEMMEEVQSLQEKIDERH-HSQQAPQAEAPCL 695
P + + L+K E+ ++V+ LQ +I R S + + A C+
Sbjct: 585 PRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTSSSERASSPAQCV 636
>gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 144 bits (362), Expect = 4e-34
Identities = 126/435 (28%), Positives = 196/435 (45%), Gaps = 69/435 (15%)
Query: 143 CKDLRVFQFCLRYTKEEEVKR-IVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNH 201
CKD+R +F + E +R I ++ + LF F Y P+N
Sbjct: 83 CKDIRNLRFA--HKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVF-------PENG 133
Query: 202 TVMFDTLKDWCWELERTKG--NMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR--- 256
++D L ++ R +G N ++ +NE Y++C+ PA VVP +P+E ++R
Sbjct: 134 WKLYDPLLEY-----RRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVAS 188
Query: 257 FQGHG-IPIWCWSCHNGSALLKMSALP---------KEQDDGILQIQKSFLDG--IYKTI 304
F+ G IP+ W A + + P KE + + I S I+
Sbjct: 189 FRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFD 248
Query: 305 HRPPYEIV---------KTEDLSSN----FLSLQEIQTAYSKFKQL--FLIDNSTEFWDT 349
RP V ++ED N FL + I ++L + N E
Sbjct: 249 ARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEE---- 304
Query: 350 DIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMM 409
W S LES+ WL+ I+ L A+ I + +E+ +V++ + D ++SL LM+
Sbjct: 305 -THWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLML 363
Query: 410 DPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQN--DKEEVPVFLLFLDCVWQLVHQHP 467
D + RT GF+ L++KEW+ GH F R H +N D + PVFL F+DCVWQ+ Q P
Sbjct: 364 DGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFP 423
Query: 468 PAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDW-SV 526
AFEF E +L + D LY +F TF NS Q+ G+E + P +++W + +
Sbjct: 424 TAFEFNEYFLITILDHLYSCLFGTFLCNSEQQR----GKE-----NLPKRTVSLWSYINS 474
Query: 527 QFEPKAQTLLKNPLY 541
Q E NPLY
Sbjct: 475 QLED-----FTNPLY 484
Score = 31.6 bits (70), Expect = 2.8
Identities = 25/112 (22%), Positives = 49/112 (43%), Gaps = 10/112 (8%)
Query: 588 KNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWI 647
+NL + +S + +L+D Y S+ + +L P +++W Y+RW
Sbjct: 459 ENLPKRTVSLWSYINSQLEDFTNPLYGSYSNH------VLYPVASMRHLELWVGYYIRWN 512
Query: 648 PE---AQILGGGQVATLSKLLEMMEEVQSLQEKIDERH-HSQQAPQAEAPCL 695
P + + L+K E+ ++V+ LQ +I R S + + A C+
Sbjct: 513 PRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTSSSERASSPAQCV 564
>gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 144 bits (362), Expect = 4e-34
Identities = 126/435 (28%), Positives = 196/435 (45%), Gaps = 69/435 (15%)
Query: 143 CKDLRVFQFCLRYTKEEEVKR-IVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPKNH 201
CKD+R +F + E +R I ++ + LF F Y P+N
Sbjct: 83 CKDIRNLRFA--HKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVF-------PENG 133
Query: 202 TVMFDTLKDWCWELERTKG--NMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR--- 256
++D L ++ R +G N ++ +NE Y++C+ PA VVP +P+E ++R
Sbjct: 134 WKLYDPLLEY-----RRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVAS 188
Query: 257 FQGHG-IPIWCWSCHNGSALLKMSALP---------KEQDDGILQIQKSFLDG--IYKTI 304
F+ G IP+ W A + + P KE + + I S I+
Sbjct: 189 FRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFD 248
Query: 305 HRPPYEIV---------KTEDLSSN----FLSLQEIQTAYSKFKQL--FLIDNSTEFWDT 349
RP V ++ED N FL + I ++L + N E
Sbjct: 249 ARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEE---- 304
Query: 350 DIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMM 409
W S LES+ WL+ I+ L A+ I + +E+ +V++ + D ++SL LM+
Sbjct: 305 -THWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLML 363
Query: 410 DPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQN--DKEEVPVFLLFLDCVWQLVHQHP 467
D + RT GF+ L++KEW+ GH F R H +N D + PVFL F+DCVWQ+ Q P
Sbjct: 364 DGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFP 423
Query: 468 PAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDW-SV 526
AFEF E +L + D LY +F TF NS Q+ G+E + P +++W + +
Sbjct: 424 TAFEFNEYFLITILDHLYSCLFGTFLCNSEQQR----GKE-----NLPKRTVSLWSYINS 474
Query: 527 QFEPKAQTLLKNPLY 541
Q E NPLY
Sbjct: 475 QLED-----FTNPLY 484
Score = 31.6 bits (70), Expect = 2.8
Identities = 25/112 (22%), Positives = 49/112 (43%), Gaps = 10/112 (8%)
Query: 588 KNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWI 647
+NL + +S + +L+D Y S+ + +L P +++W Y+RW
Sbjct: 459 ENLPKRTVSLWSYINSQLEDFTNPLYGSYSNH------VLYPVASMRHLELWVGYYIRWN 512
Query: 648 PE---AQILGGGQVATLSKLLEMMEEVQSLQEKIDERH-HSQQAPQAEAPCL 695
P + + L+K E+ ++V+ LQ +I R S + + A C+
Sbjct: 513 PRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTSSSERASSPAQCV 564
>gi|4557896 myotubularin [Homo sapiens]
Length = 603
Score = 135 bits (341), Expect = 1e-31
Identities = 120/439 (27%), Positives = 198/439 (45%), Gaps = 63/439 (14%)
Query: 139 LIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDP 198
L I CKD+R +F L+ +E +R + I+ P L L LF++ + N
Sbjct: 109 LDITCKDMRNLRFALK--QEGHSRRDMFEILTRYAFP-LAHSLPLFAFLNEEKFNV---- 161
Query: 199 KNHTVMFDTLKDWCWELERTKG--NMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR 256
+ +++ ++++ R +G N ++ +N+ Y++C+ PA VVP +++++R
Sbjct: 162 -DGWTVYNPVEEY-----RRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRR 215
Query: 257 F----QGHGIPIWCWSCHNGSA--------LLKMSALPKEQDDGILQIQKSFLDGIYK-T 303
+ IP+ W L+ MS + D+ L + + I K T
Sbjct: 216 VATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLT 275
Query: 304 IH--RPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIK--------- 352
I+ RP V + + E AY + FL ++ +K
Sbjct: 276 IYDARPSVNAVANKATGGGY----ESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPN 331
Query: 353 -----WFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQL 407
W S LES+ WL+ I+ L AI++ + + + +VL+ + D ++SL L
Sbjct: 332 VEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAML 391
Query: 408 MMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQN--DKEEVPVFLLFLDCVWQLVHQ 465
M+D R+ GF+ L+QKEW+ GH F R H +N D + P+FL F+DCVWQ+ Q
Sbjct: 392 MLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQ 451
Query: 466 HPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWS 525
P AFEF E +L ++ D LY F TF FN RE Q + ++L WS
Sbjct: 452 FPTAFEFNEQFLIIILDHLYSCRFGTFLFN------CESARERQKVTERTVSL-----WS 500
Query: 526 VQFEPKAQTLLKNPLYVEK 544
+ K + KNP Y ++
Sbjct: 501 LINSNKEK--FKNPFYTKE 517
>gi|28872761 myotubularin-related protein 1 [Homo sapiens]
Length = 665
Score = 135 bits (339), Expect = 2e-31
Identities = 107/390 (27%), Positives = 179/390 (45%), Gaps = 44/390 (11%)
Query: 141 IHCKDLRVFQFCLRYTKEEEVKR-IVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDPK 199
I CKD+R + L Y +EE+ K I + H + LF FSY P
Sbjct: 174 IVCKDMRNLR--LAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKF-------PI 224
Query: 200 NHTVMFDTLKDWCWELERTKG--NMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR- 256
N ++D + ++ + +G N +K +N Y+ C+ PA VVPT + ++++ +
Sbjct: 225 NGWKVYDPVSEY-----KRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKV 279
Query: 257 --FQGHG-IPIWCWSCHNGSALLKMSALPKE-QDDGILQIQKSFLDGIYKTIHRPPYEIV 312
F+ G +P+ W A + + P +D + + +L I + I+
Sbjct: 280 AAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLII 339
Query: 313 ------KTEDLSSNFLSLQEIQTAYSKFKQLFL-IDNSTEFWDT-------------DIK 352
D + E ++AY + +FL I N ++ + +
Sbjct: 340 FDARQNSVADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEAR 399
Query: 353 WFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPH 412
W S ++ + WL+ IR L A+ I + +E+ +V++ + D ++SL LM+D +
Sbjct: 400 WLSNVDGTHWLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSY 459
Query: 413 CRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQN--DKEEVPVFLLFLDCVWQLVHQHPPAF 470
RT GF++L++KEW+ GH F R H N D + P+FL F+DCVWQ+ Q P AF
Sbjct: 460 YRTIKGFETLVEKEWISFGHRFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAF 519
Query: 471 EFTETYLTVLSDSLYIPIFSTFFFNSPHQK 500
EF E +L + D LY +F TF N Q+
Sbjct: 520 EFNELFLITILDHLYSCLFGTFLCNCEQQR 549
>gi|19923424 myotubularin related protein 9 [Homo sapiens]
Length = 549
Score = 127 bits (319), Expect = 4e-29
Identities = 114/446 (25%), Positives = 183/446 (41%), Gaps = 82/446 (18%)
Query: 139 LIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDP 198
+II CKD R+ Q L EE I S I + + T+ P
Sbjct: 69 IIIKCKDFRIIQ--LDIPGMEECLNIASSI----------------EALSTLDSITLMYP 110
Query: 199 KNHTVMFDTLKD-WCWELERTKGNMKYKAVS------VNEGYKVCERLPAYFVVPTPLPE 251
+ MF+ ++D W L + + A S VN+ + VC P VP + +
Sbjct: 111 FFYRPMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDD 170
Query: 252 ENVQRF----QGHGIPIWCWSCHNGSALLKMSALPKEQDDG------------------- 288
E +++ G P+ + ++ S P +G
Sbjct: 171 EALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKR 230
Query: 289 ----------ILQIQKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLF 338
+ Q ++ G + H P + + + LQE S K +
Sbjct: 231 GYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKS--IERYHILQE-----SLIKLVE 283
Query: 339 LIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLC 398
++ T D +W S LE+S+WL I+ L A +C++ + ++L+ +D
Sbjct: 284 ACNDQTHNMD---RWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDST 340
Query: 399 CLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRC---NHLRQNDKEEVPVFLLF 455
++SL Q++++P RT GF++LI++EW+ GH F RC + K E PVFLLF
Sbjct: 341 LQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLF 400
Query: 456 LDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKP 515
LDCVWQ++ Q P +FEF E +L +L + Y F TF N+ + R Q K
Sbjct: 401 LDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESE------RCKLKLQQKT 454
Query: 516 LNLLTVWDWSVQFEPKAQTLLKNPLY 541
++L W W Q P + NPL+
Sbjct: 455 MSL---WSWVNQ--PSELSKFTNPLF 475
>gi|21361759 myotubularin related protein 8 [Homo sapiens]
Length = 704
Score = 122 bits (307), Expect = 9e-28
Identities = 113/430 (26%), Positives = 183/430 (42%), Gaps = 51/430 (11%)
Query: 139 LIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDP 198
L + CK+ RV F L + + ++ +Q P L + L+ FSY +
Sbjct: 70 LTLRCKNFRVAHFVL--DSDLVCHEVYISLLKLSQ-PALPEDLYAFSYNPKSSKEM---R 123
Query: 199 KNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENV---Q 255
++ + D + D+ N + N Y++C P VVP + V
Sbjct: 124 ESGWKLIDPISDFG---RMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSS 180
Query: 256 RFQG-HGIPIWCWSCHNGSALLKMSALPKE-------QDDGILQIQKSFLDG---IYKTI 304
+F+ +P+ + +A + + P D+ +L+ G +Y
Sbjct: 181 KFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVD 240
Query: 305 HRPPYEIV---------KTEDLSSN----FLSLQEIQTAYSKFKQLFLIDNSTEFWDTDI 351
RP + + ED +N F+ ++ I S ++L + T
Sbjct: 241 TRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKT--PTMS 298
Query: 352 KWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDP 411
++ S LESS WL I+ + I IT+ ++ + +VL+ + D + S+ +++DP
Sbjct: 299 EFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDP 358
Query: 412 HCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFE 471
RT G LI+KEW+ GH F RC HL + KE P+F FLDC+WQL+ Q P AFE
Sbjct: 359 FYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFE 418
Query: 472 FTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPK 531
F E +L + D ++ F F N QKD R + T S VW + VQ +P
Sbjct: 419 FNENFLLEIHDHVFSCQFGNFLGNC--QKDREDLRVYEKTHS-------VWPFLVQRKPD 469
Query: 532 AQTLLKNPLY 541
+NPLY
Sbjct: 470 ----FRNPLY 475
>gi|134142348 myotubularin related protein 6 [Homo sapiens]
Length = 621
Score = 118 bits (295), Expect = 2e-26
Identities = 117/431 (27%), Positives = 192/431 (44%), Gaps = 53/431 (12%)
Query: 139 LIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDP 198
L+I CK+ R F + +E + I + ++ ++ K + L+ FSY QN++
Sbjct: 68 LVIQCKNFRTVHFIV--PRERDCHDIYNSLLQLSKQAKY-EDLYAFSY-NPKQNDS---- 119
Query: 199 KNHTVMFDTLKDWCWELERTK-GNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENV--- 254
+ L D E +R N ++ N YK+CE P VP + +
Sbjct: 120 --ERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGS 177
Query: 255 QRFQGHG-IPIWCWSCHNGSALLKMSALPKE-------QDDGILQ-IQKSFLDGIYKTIH 305
+F+ G P+ + + A + + P +D+ +LQ I K+ Y +
Sbjct: 178 SKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVM 237
Query: 306 --RPPYEIV---------KTEDLSSN----FLSLQEIQTAYSKFKQLFLIDNSTEFWDTD 350
RP + + ED SN F+ ++ I S ++L ++ + D
Sbjct: 238 DTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVND 297
Query: 351 IKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMD 410
++S LESS WL I+ + AI + + + +N +VL+ + D + SL L++D
Sbjct: 298 --FYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLD 355
Query: 411 PHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAF 470
+ RT GF LI+K+W+ GH F +RC L + KE PVF FL+CVW L Q P AF
Sbjct: 356 SYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAF 415
Query: 471 EFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEP 530
EF+E +L + + ++ F F N QK+ RE + K +L W E
Sbjct: 416 EFSEAFLLQIHEHIHSCQFGNFLGNC--QKE----REELKLKEKTYSL-----WPFLLED 464
Query: 531 KAQTLLKNPLY 541
+ + L NPLY
Sbjct: 465 QKKYL--NPLY 473
>gi|225543474 myotubularin related protein 7 [Homo sapiens]
Length = 660
Score = 108 bits (271), Expect = 1e-23
Identities = 97/392 (24%), Positives = 168/392 (42%), Gaps = 44/392 (11%)
Query: 139 LIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDP 198
L+I CK+ ++ Q + +E + + +I + P + L+ FS+ N + D
Sbjct: 70 LLIRCKNFQIIQLII--PQERDCHDVYISLIRLAR-PVKYEELYCFSF------NPMLDK 120
Query: 199 KNHT---VMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENV- 254
+ V+ D +++ N ++ VN Y+VC+ P VP +
Sbjct: 121 EEREQGWVLIDLSEEYT---RMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIV 177
Query: 255 --QRFQGHG-IPIWCWS--------CHNGSALLKMSALPKEQDDGILQIQKSF--LDGIY 301
+F+ P+ + C + L SA E + + I+K+ D +Y
Sbjct: 178 GSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVY 237
Query: 302 KTIHRPPYEIV---------KTEDLSSN----FLSLQEIQTAYSKFKQLFLIDNSTEFWD 348
RP + + ED SN F+ ++ I + +++ +
Sbjct: 238 VVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSM 297
Query: 349 TDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLM 408
+D W LE+S WL I+ + I I + + + +VL+ + D + S+ L+
Sbjct: 298 SDFLWG--LENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLL 355
Query: 409 MDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPP 468
+DPH RT GF LI+K+W+ GH F R +L + KE PV F++CVWQL+ Q P
Sbjct: 356 LDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPC 415
Query: 469 AFEFTETYLTVLSDSLYIPIFSTFFFNSPHQK 500
AFEF E +L + +Y F F NS ++
Sbjct: 416 AFEFNERFLIHIQHHIYSCQFGNFLCNSQKER 447
>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
Length = 1161
Score = 108 bits (270), Expect = 2e-23
Identities = 65/182 (35%), Positives = 95/182 (52%), Gaps = 5/182 (2%)
Query: 321 FLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECM 380
F+ + I + F+ L L+ T+ D W S LES+ WL + LK A+ + +
Sbjct: 346 FMGMANIHSIRRSFQSLRLL--CTQMPDPG-NWLSALESTKWLHHLSVLLKSALLVVHAV 402
Query: 381 EAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH 440
+ VL+ + D I +L +L++DP+ RT GFQ L++ EW+ GH F DRC H
Sbjct: 403 DQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH 462
Query: 441 LRQND--KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPH 498
+D E PVFL +LDCV QL Q P +FEF E +L L Y +F TF N+
Sbjct: 463 GENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAK 522
Query: 499 QK 500
++
Sbjct: 523 ER 524
Score = 32.7 bits (73), Expect = 1.3
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 22/131 (16%)
Query: 138 KLIIHCKDLRVF--QFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSY--------- 186
+L + CKD +V QF +E +KR+ + I + P ++ LF F+Y
Sbjct: 86 QLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAI----RPPAKIEDLFSFAYHAWCMEVYA 141
Query: 187 ATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK--YKAVSVNEGYKVCERLPAYFV 244
+ Q+ + P H K+ E+ER +M ++ ++NE YK+C P +
Sbjct: 142 SEKEQHGDLCRPGEHVT--SRFKN---EVERMGFDMNNAWRISNINEKYKLCGSYPQELI 196
Query: 245 VPTPLPEENVQ 255
VP + ++ ++
Sbjct: 197 VPAWITDKELE 207
>gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]
Length = 1170
Score = 108 bits (270), Expect = 2e-23
Identities = 65/182 (35%), Positives = 95/182 (52%), Gaps = 5/182 (2%)
Query: 321 FLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECM 380
F+ + I + F+ L L+ T+ D W S LES+ WL + LK A+ + +
Sbjct: 346 FMGMANIHSIRRSFQSLRLL--CTQMPDPG-NWLSALESTKWLHHLSVLLKSALLVVHAV 402
Query: 381 EAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH 440
+ VL+ + D I +L +L++DP+ RT GFQ L++ EW+ GH F DRC H
Sbjct: 403 DQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH 462
Query: 441 LRQND--KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPH 498
+D E PVFL +LDCV QL Q P +FEF E +L L Y +F TF N+
Sbjct: 463 GENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAK 522
Query: 499 QK 500
++
Sbjct: 523 ER 524
Score = 32.7 bits (73), Expect = 1.3
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 22/131 (16%)
Query: 138 KLIIHCKDLRVF--QFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSY--------- 186
+L + CKD +V QF +E +KR+ + I + P ++ LF F+Y
Sbjct: 86 QLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAI----RPPAKIEDLFSFAYHAWCMEVYA 141
Query: 187 ATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK--YKAVSVNEGYKVCERLPAYFV 244
+ Q+ + P H K+ E+ER +M ++ ++NE YK+C P +
Sbjct: 142 SEKEQHGDLCRPGEHVT--SRFKN---EVERMGFDMNNAWRISNINEKYKLCGSYPQELI 196
Query: 245 VPTPLPEENVQ 255
VP + ++ ++
Sbjct: 197 VPAWITDKELE 207
>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
Length = 1198
Score = 108 bits (270), Expect = 2e-23
Identities = 65/182 (35%), Positives = 95/182 (52%), Gaps = 5/182 (2%)
Query: 321 FLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECM 380
F+ + I + F+ L L+ T+ D W S LES+ WL + LK A+ + +
Sbjct: 346 FMGMANIHSIRRSFQSLRLL--CTQMPDPG-NWLSALESTKWLHHLSVLLKSALLVVHAV 402
Query: 381 EAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH 440
+ VL+ + D I +L +L++DP+ RT GFQ L++ EW+ GH F DRC H
Sbjct: 403 DQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH 462
Query: 441 LRQND--KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPH 498
+D E PVFL +LDCV QL Q P +FEF E +L L Y +F TF N+
Sbjct: 463 GENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAK 522
Query: 499 QK 500
++
Sbjct: 523 ER 524
Score = 32.7 bits (73), Expect = 1.3
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 22/131 (16%)
Query: 138 KLIIHCKDLRVF--QFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSY--------- 186
+L + CKD +V QF +E +KR+ + I + P ++ LF F+Y
Sbjct: 86 QLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAI----RPPAKIEDLFSFAYHAWCMEVYA 141
Query: 187 ATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK--YKAVSVNEGYKVCERLPAYFV 244
+ Q+ + P H K+ E+ER +M ++ ++NE YK+C P +
Sbjct: 142 SEKEQHGDLCRPGEHVT--SRFKN---EVERMGFDMNNAWRISNINEKYKLCGSYPQELI 196
Query: 245 VPTPLPEENVQ 255
VP + ++ ++
Sbjct: 197 VPAWITDKELE 207
>gi|217272865 myotubularin related protein 4 [Homo sapiens]
Length = 1195
Score = 103 bits (256), Expect = 8e-22
Identities = 54/151 (35%), Positives = 85/151 (56%), Gaps = 2/151 (1%)
Query: 353 WFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPH 412
W S LES+ WL + LK A+ + ++ + VL+ + D I +L ++++DP+
Sbjct: 369 WLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPY 428
Query: 413 CRTRIGFQSLIQKEWVMGGHCFLDRCNHLR--QNDKEEVPVFLLFLDCVWQLVHQHPPAF 470
RT GFQ L++ +W+ GH F DRC H ++ E+ PVFL +LD V QL+ Q P F
Sbjct: 429 YRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLF 488
Query: 471 EFTETYLTVLSDSLYIPIFSTFFFNSPHQKD 501
EF E +L L Y ++ TF N+P +++
Sbjct: 489 EFNEAFLVKLVQHTYSCLYGTFLANNPCERE 519
Score = 31.2 bits (69), Expect = 3.7
Identities = 36/151 (23%), Positives = 61/151 (40%), Gaps = 11/151 (7%)
Query: 138 KLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTD 197
+L I CKD +V + ++ ++ + +S + T P + LF F+Y T D
Sbjct: 86 QLHISCKDSKVVR--CHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEED 143
Query: 198 PKNHTVMFDTLKDWCWELERTKGNMKYKAV----SVNEGYKVCERLPAYFVVPTPLPE-- 251
H E E + + V +N YK+C P +VP + +
Sbjct: 144 QHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKE 203
Query: 252 -ENVQRFQG-HGIPIWCW-SCHNGSALLKMS 279
ENV F+ IP+ + NG+A+ + S
Sbjct: 204 LENVASFRSWKRIPVVVYRHLRNGAAIARCS 234
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 100 bits (248), Expect = 6e-21
Identities = 76/250 (30%), Positives = 120/250 (48%), Gaps = 8/250 (3%)
Query: 322 LSLQEIQTAYSKFKQLF-LIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECM 380
+ EI+ + FK+L ST D+++ + L S W + R ++ A+ ++E +
Sbjct: 1341 VEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVL 1400
Query: 381 EAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCN- 439
E +VL+ E D+ ++SLVQL+ DP RT GFQ L++KEW+ GH F R +
Sbjct: 1401 E-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSL 1459
Query: 440 HLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQ 499
L PVFL FLDCV Q+ +Q+P FEF YL L+ F TF +S ++
Sbjct: 1460 TLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYE 1519
Query: 500 K---DTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPLYVE--KPKLDKGQRKG 554
+ T +G+ K + + D + P L +PL +E KP ++ K
Sbjct: 1520 RLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKK 1579
Query: 555 MRFKHQRQLS 564
+ + LS
Sbjct: 1580 WDYYIEETLS 1589
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 88.6 bits (218), Expect = 2e-17
Identities = 55/145 (37%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
Query: 357 LESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTR 416
LE S WL I + L+ ++ + E +++ + +VL+ E+ D+ + SLVQL+ DP RT
Sbjct: 1414 LEDSEWLIQIHKLLQVSVLVVELLDSGS-SVLVGLEDGWDITTQVVSLVQLLSDPFYRTL 1472
Query: 417 IGFQSLIQKEWVMGGHCFLDRCNH-LRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTET 475
GF+ L++KEW+ GH F R H L PVFL FLDCV Q+ Q P FEF++
Sbjct: 1473 EGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQF 1532
Query: 476 YLTVLSDSLYIPIFSTFFFNSPHQK 500
YL L F TF +S +++
Sbjct: 1533 YLKFLGYHHVSRRFRTFLLDSDYER 1557
Score = 32.7 bits (73), Expect = 1.3
Identities = 18/69 (26%), Positives = 30/69 (43%), Gaps = 5/69 (7%)
Query: 215 LERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR----FQGHGIPIWCWSCH 270
L R K ++ VN Y +C P +VP + + +QR ++ + P+ CW
Sbjct: 1142 LSRAKSE-PFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSG 1200
Query: 271 NGSALLKMS 279
A+L S
Sbjct: 1201 RSKAVLLRS 1209
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 30.8 bits (68), Expect = 4.8
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 5/74 (6%)
Query: 500 KDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPL---YVEKPKLDKGQRKGMR 556
+DT + R GQ T + P + DW++ FE +LL P Y +KP +
Sbjct: 1185 EDTVLVRSGQGTAALPRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSA- 1243
Query: 557 FKHQRQLSLPLTQS 570
K+ R + PLT +
Sbjct: 1244 -KNIRMMGKPLTSA 1256
>gi|55769583 progesterone-induced blocking factor 1 [Homo sapiens]
Length = 757
Score = 30.4 bits (67), Expect = 6.3
Identities = 25/95 (26%), Positives = 44/95 (46%), Gaps = 6/95 (6%)
Query: 599 INSSDELQDNFREFYDSWHSKSTDY-HGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQ 657
+ D+L D +RE S SK T++ H L E +++ + R + + Q+ +
Sbjct: 432 LEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQL----E 487
Query: 658 VATLSKLLEMM-EEVQSLQEKIDERHHSQQAPQAE 691
K LE++ +E SLQ ++R QA +E
Sbjct: 488 CEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSE 522
>gi|4758650 kinesin family member 5C [Homo sapiens]
Length = 957
Score = 30.0 bits (66), Expect = 8.2
Identities = 18/84 (21%), Positives = 37/84 (44%), Gaps = 3/84 (3%)
Query: 93 DNDETQFKNKVIGEN---DITLHCVDQIYGVFDEKKKTLFGQLKKYPEKLIIHCKDLRVF 149
D+ T+ +G N I + C ++ + K +FGQ K + + +L
Sbjct: 281 DSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAE 340
Query: 150 QFCLRYTKEEEVKRIVSGIIHHTQ 173
++ +Y KE+E + + +I H +
Sbjct: 341 EWKKKYEKEKEKNKTLKNVIQHLE 364
>gi|34452713 Ca2+-dependent secretion activator isoform 2 [Homo
sapiens]
Length = 1314
Score = 30.0 bits (66), Expect = 8.2
Identities = 15/37 (40%), Positives = 20/37 (54%)
Query: 9 GGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHL 45
GGG +P PS VS EE+ +KE E++ L L
Sbjct: 85 GGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQL 121
>gi|34452715 Ca2+-dependent secretion activator isoform 1 [Homo
sapiens]
Length = 1353
Score = 30.0 bits (66), Expect = 8.2
Identities = 15/37 (40%), Positives = 20/37 (54%)
Query: 9 GGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHL 45
GGG +P PS VS EE+ +KE E++ L L
Sbjct: 85 GGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQL 121
>gi|34452711 Ca2+-dependent secretion activator isoform 3 [Homo
sapiens]
Length = 1274
Score = 30.0 bits (66), Expect = 8.2
Identities = 15/37 (40%), Positives = 20/37 (54%)
Query: 9 GGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHL 45
GGG +P PS VS EE+ +KE E++ L L
Sbjct: 85 GGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQL 121
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,063,856
Number of Sequences: 37866
Number of extensions: 1407231
Number of successful extensions: 3504
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3426
Number of HSP's gapped (non-prelim): 43
length of query: 747
length of database: 18,247,518
effective HSP length: 110
effective length of query: 637
effective length of database: 14,082,258
effective search space: 8970398346
effective search space used: 8970398346
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.