Search of human proteins with 94557297

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94557297 mitogen-activated protein kinase 8 interacting
protein 3 isoform 1 [Homo sapiens]
         (1336 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94557297 mitogen-activated protein kinase 8 interacting prote...  2692   0.0  
gi|94557295 mitogen-activated protein kinase 8 interacting prote...  2673   0.0  
gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]      1387   0.0  
gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]     1384   0.0  
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   144   6e-34
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...   112   2e-24
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...   112   2e-24
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...   102   2e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    59   4e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    57   2e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    57   2e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    57   2e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    57   2e-07
gi|56961680 coiled-coil domain containing 147 [Homo sapiens]           54   1e-06
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    52   4e-06
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    52   4e-06
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 51   7e-06
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         50   1e-05
gi|93204881 Rab interacting lysosomal protein [Homo sapiens]           50   1e-05
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         49   2e-05
gi|195947382 Rab interacting lysosomal protein-like 1 [Homo sapi...    49   2e-05
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]                48   6e-05
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           47   9e-05
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           47   9e-05
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           47   9e-05
gi|215982794 myosin VA isoform 2 [Homo sapiens]                        47   9e-05
gi|215982791 myosin VA isoform 1 [Homo sapiens]                        47   9e-05
gi|55770834 centromere protein F [Homo sapiens]                        47   9e-05
gi|4505101 microtubule-associated protein 7 [Homo sapiens]             47   9e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    47   1e-04

>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
            isoform 1 [Homo sapiens]
          Length = 1336

 Score = 2692 bits (6978), Expect = 0.0
 Identities = 1336/1336 (100%), Positives = 1336/1336 (100%)

Query: 1    MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60
            MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV
Sbjct: 1    MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60

Query: 61   NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120
            NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK
Sbjct: 61   NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120

Query: 121  ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180
            ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE
Sbjct: 121  ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180

Query: 181  RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240
            RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ
Sbjct: 181  RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240

Query: 241  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
            LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV
Sbjct: 241  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300

Query: 301  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
            GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD
Sbjct: 301  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360

Query: 361  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV 420
            RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV
Sbjct: 361  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV 420

Query: 421  GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 480
            GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE
Sbjct: 421  GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 480

Query: 481  EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 540
            EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE
Sbjct: 481  EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 540

Query: 541  RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 600
            RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY
Sbjct: 541  RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 600

Query: 601  KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR 660
            KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR
Sbjct: 601  KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR 660

Query: 661  LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP 720
            LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP
Sbjct: 661  LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP 720

Query: 721  NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL 780
            NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL
Sbjct: 721  NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL 780

Query: 781  TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD 840
            TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD
Sbjct: 781  TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD 840

Query: 841  GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE 900
            GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE
Sbjct: 841  GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE 900

Query: 901  VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP 960
            VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP
Sbjct: 901  VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP 960

Query: 961  TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT 1020
            TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT
Sbjct: 961  TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT 1020

Query: 1021 LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS 1080
            LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS
Sbjct: 1021 LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS 1080

Query: 1081 FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL 1140
            FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL
Sbjct: 1081 FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL 1140

Query: 1141 GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP 1200
            GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP
Sbjct: 1141 GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP 1200

Query: 1201 GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS 1260
            GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS
Sbjct: 1201 GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS 1260

Query: 1261 PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK 1320
            PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK
Sbjct: 1261 PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK 1320

Query: 1321 AERSHIIVWQVSYTPE 1336
            AERSHIIVWQVSYTPE
Sbjct: 1321 AERSHIIVWQVSYTPE 1336


>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
            isoform 2 [Homo sapiens]
          Length = 1330

 Score = 2673 bits (6928), Expect = 0.0
 Identities = 1330/1336 (99%), Positives = 1330/1336 (99%), Gaps = 6/1336 (0%)

Query: 1    MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60
            MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV
Sbjct: 1    MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60

Query: 61   NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120
            NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK
Sbjct: 61   NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120

Query: 121  ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180
            ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE
Sbjct: 121  ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180

Query: 181  RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240
            RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ
Sbjct: 181  RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240

Query: 241  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
            LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV
Sbjct: 241  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300

Query: 301  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
            GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD
Sbjct: 301  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360

Query: 361  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV 420
            RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFS      GMGKEV
Sbjct: 361  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFS------GMGKEV 414

Query: 421  GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 480
            GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE
Sbjct: 415  GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 474

Query: 481  EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 540
            EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE
Sbjct: 475  EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 534

Query: 541  RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 600
            RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY
Sbjct: 535  RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 594

Query: 601  KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR 660
            KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR
Sbjct: 595  KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR 654

Query: 661  LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP 720
            LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP
Sbjct: 655  LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP 714

Query: 721  NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL 780
            NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL
Sbjct: 715  NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL 774

Query: 781  TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD 840
            TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD
Sbjct: 775  TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD 834

Query: 841  GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE 900
            GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE
Sbjct: 835  GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE 894

Query: 901  VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP 960
            VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP
Sbjct: 895  VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP 954

Query: 961  TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT 1020
            TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT
Sbjct: 955  TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT 1014

Query: 1021 LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS 1080
            LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS
Sbjct: 1015 LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS 1074

Query: 1081 FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL 1140
            FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL
Sbjct: 1075 FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL 1134

Query: 1141 GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP 1200
            GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP
Sbjct: 1135 GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP 1194

Query: 1201 GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS 1260
            GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS
Sbjct: 1195 GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS 1254

Query: 1261 PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK 1320
            PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK
Sbjct: 1255 PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK 1314

Query: 1321 AERSHIIVWQVSYTPE 1336
            AERSHIIVWQVSYTPE
Sbjct: 1315 AERSHIIVWQVSYTPE 1330


>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
          Length = 1307

 Score = 1387 bits (3589), Expect = 0.0
 Identities = 776/1369 (56%), Positives = 976/1369 (71%), Gaps = 100/1369 (7%)

Query: 6    MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65
            M+   GVV  ++   SG+VMSERVSGLAGSIYREFERLI  YDEEVVKELMPLVV VLEN
Sbjct: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60

Query: 66   LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125
            LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120

Query: 126  VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185
            VE  E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI  Y+EH+ER+K+ 
Sbjct: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180

Query: 186  QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240
            Q+ G+ Q ES+   R RKERP SL +FPL  G    T  AQ GG+  P  + W   +L Q
Sbjct: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239

Query: 241  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
             +S +S +    ++S+ G  S A TP++T   +N+  +++P+   TPL E  +       
Sbjct: 240  PRSHTSLKDELSDVSQGG--SKATTPAST---ANSDVATIPTD--TPLKEENEGF----- 287

Query: 301  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
              K +    +   S+++EVQV QE RNVS G   ++E S+VQ II+STPELDM  +    
Sbjct: 288  -VKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 346

Query: 361  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV 420
            +  S+PT+GI NKAF  NT+SL+ ELS+AGS +IGDVDEGADLLG          MG+EV
Sbjct: 347  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----------MGREV 396

Query: 421  GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 480
             NL+LEN+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +ELE
Sbjct: 397  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELE 456

Query: 481  EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 540
            EEL++ ++EA  AR++ K++          +   IP AQR+RFTRVEMARVLMERNQYKE
Sbjct: 457  EELRKARAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQYKE 506

Query: 541  RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 600
            RLMELQEAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+    K+P P VN+ Y
Sbjct: 507  RLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVNLKY 564

Query: 601  KSPTT--AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREHVRN 656
             +PT+      ++R+  +  +    S+  +F  ++ + + ++RREQKREQYRQV+ HV+ 
Sbjct: 565  NAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQK 624

Query: 657  DDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLS 716
            +DGR+QA GWSLP KYKQ++   GQ + +MKN+PVPVY RPL EKD +MKLWCA GVNLS
Sbjct: 625  EDGRVQAFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLS 682

Query: 717  GWRPNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMDATS 770
            G +  +  +  G      +D    D EG  +  ++ +S +K      ++ KEL   +  S
Sbjct: 683  GGKTRDGGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 741

Query: 771  SRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDS 830
            S VWI TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE   +S
Sbjct: 742  SLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSES 801

Query: 831  D-----------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQGEV 878
                         +      D +L GIT+VGC+        ++ S+ G +PV+DK     
Sbjct: 802  GQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEME 861

Query: 879  ATIANGKVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP-----S 932
            A   N +V+ +  T EEATEATE  + G +E      + G  TEHVFTDP         S
Sbjct: 862  AE--NSEVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLS 918

Query: 933  SGPQPGSENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKK 991
               Q  +++    D  S  P E +   +     SS  PTMWLGAQNG LYVHS+VA W+K
Sbjct: 919  PVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRK 978

Query: 992  CLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRC 1051
            CLHSIKLKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHSIRC
Sbjct: 979  CLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRC 1038

Query: 1052 MAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTL 1111
            M VV+D+VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLDSTL
Sbjct: 1039 MTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTL 1098

Query: 1112 RLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPL 1171
            RLYHAHT+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+ISIPL
Sbjct: 1099 RLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPL 1158

Query: 1172 TETVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQAQL 1230
            TET             NKTS   G   RPG +I VYGD++SD+    +FIPYCSMA AQL
Sbjct: 1159 TET-------------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQL 1203

Query: 1231 CFHGHRDAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLVLSG 1287
            CFHGHRDAVKFFV+VPG V+   ++ +G+ L     GP    P S+     L+++LV+SG
Sbjct: 1204 CFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLVISG 1260

Query: 1288 GEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1336
            GEGYIDFR+GD E  E+E   G+   ++P ++KAERSH+IVWQV Y  E
Sbjct: 1261 GEGYIDFRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1307


>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
          Length = 1321

 Score = 1384 bits (3583), Expect = 0.0
 Identities = 776/1372 (56%), Positives = 971/1372 (70%), Gaps = 92/1372 (6%)

Query: 6    MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65
            M+   GVV  ++   SG+VMSERVSGLAGSIYREFERLI  YDEEVVKELMPLVV VLEN
Sbjct: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60

Query: 66   LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125
            LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120

Query: 126  VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185
            VE  E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI  Y+EH+ER+K+ 
Sbjct: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180

Query: 186  QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240
            Q+ G+ Q ES+   R RKERP SL +FPL  G    T  AQ GG+  P  + W   +L Q
Sbjct: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239

Query: 241  LQSSSSYQCPQDEMSESG--QSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDY 298
             +S +S +       +    Q    +  S  G+K+ TP S+  S   T   ++  PL + 
Sbjct: 240  PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDT--PLKEE 297

Query: 299  GVGSKNSKRAREKRD-SRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPET 357
              G      A  K + S+++EVQV QE RNVS G   ++E S+VQ II+STPELDM  + 
Sbjct: 298  NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDL 357

Query: 358  RLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMG 417
               +  S+PT+GI NKAF  NT+SL+ ELS+AGS +IGDVDEGADLLG          MG
Sbjct: 358  SGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----------MG 407

Query: 418  KEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIK 477
            +EV NL+LEN+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +
Sbjct: 408  REVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNR 467

Query: 478  ELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQ 537
            ELEEEL++ ++EA  AR++ K++          +   IP AQR+RFTRVEMARVLMERNQ
Sbjct: 468  ELEEELRKARAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQ 517

Query: 538  YKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVN 597
            YKERLMELQEAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+    K+P P VN
Sbjct: 518  YKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVN 575

Query: 598  IHYKSPTT--AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREH 653
            + Y +PT+      ++R+  +  +    S+  +F  ++ + + ++RREQKREQYRQV+ H
Sbjct: 576  LKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAH 635

Query: 654  VRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGV 713
            V+ +DGR+QA GWSLP KYKQ++   GQ + +MKN+PVPVY RPL EKD +MKLWCA GV
Sbjct: 636  VQKEDGRVQAFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGV 693

Query: 714  NLSGWRPNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMD 767
            NLSG +  +  +  G      +D    D EG  +  ++ +S +K      ++ KEL   +
Sbjct: 694  NLSGGKTRDGGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQE 752

Query: 768  ATSSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMF 827
              SS VWI TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE  
Sbjct: 753  ELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDL 812

Query: 828  LDSD-----------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQ 875
             +S             +      D +L GIT+VGC+        ++ S+ G +PV+DK  
Sbjct: 813  SESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPP 872

Query: 876  GEVATIANGKVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP--- 931
               A   N +V+ +  T EEATEATE  + G +E      + G  TEHVFTDP       
Sbjct: 873  EMEAE--NSEVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPE 929

Query: 932  --SSGPQPGSENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVAN 988
              S   Q  +++    D  S  P E +   +     SS  PTMWLGAQNG LYVHS+VA 
Sbjct: 930  DLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQ 989

Query: 989  WKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHS 1048
            W+KCLHSIKLKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHS
Sbjct: 990  WRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHS 1049

Query: 1049 IRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLD 1108
            IRCM VV+D+VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLD
Sbjct: 1050 IRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLD 1109

Query: 1109 STLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVIS 1168
            STLRLYHAHT+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+IS
Sbjct: 1110 STLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIIS 1169

Query: 1169 IPLTETVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQ 1227
            IPLTET             NKTS   G   RPG +I VYGD++SD+    +FIPYCSMA 
Sbjct: 1170 IPLTET-------------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAH 1214

Query: 1228 AQLCFHGHRDAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLV 1284
            AQLCFHGHRDAVKFFV+VPG V+   ++ +G+ L     GP    P S+     L+++LV
Sbjct: 1215 AQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLV 1271

Query: 1285 LSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1336
            +SGGEGYIDFR+GD E  E+E   G+   ++P ++KAERSH+IVWQV Y  E
Sbjct: 1272 ISGGEGYIDFRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1321


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  144 bits (363), Expect = 6e-34
 Identities = 155/602 (25%), Positives = 241/602 (40%), Gaps = 91/602 (15%)

Query: 770  SSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDY--PPGEMF 827
            S  VW+  S     +V ++       V     VC+A +LCI ++P      +  PP  + 
Sbjct: 1513 SPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLR 1572

Query: 828  LDSDVNPEDPGADGVLAGITLVGCATRCNVPRSNC-------SSRGDTPVLDKGQGEVAT 880
               +  PE  G +  +        AT        C       S    TP L +G      
Sbjct: 1573 SPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPEL 1632

Query: 881  I-----ANGKVNPSQSTEEATEAT-----------EVPDPGPSEPETAT----LRPGPLT 920
            +     ++ + +PS S    ++A+           E P    +  ET +      PG L 
Sbjct: 1633 VPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLP 1692

Query: 921  EHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEP--SGDPTGAGSSAAPTMWLGAQNG 978
                  P     + P  G         S TR   E   S DP    SS    +WLG ++G
Sbjct: 1693 LSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS----VWLGTEDG 1748

Query: 979  WLYVHSAVANWKKCLHSIKLKD--SVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSN 1036
             ++V+ +  + +   +S+KL+   SV  ++++  +V V+LA+G L ++ R     WD  N
Sbjct: 1749 CVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQN 1808

Query: 1037 YHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAW 1096
            +  + LG     I  M  V  R+WCG +N+V V+ P T+Q+E  F         V  +  
Sbjct: 1809 FKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVD 1868

Query: 1097 IGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTG-----KLGFSFVRITALL 1151
               GVWV+++  + + LYH  T + L +VD+ P V +ML        +   + +RITALL
Sbjct: 1869 SSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALL 1928

Query: 1152 VAGSRLWVGTGNGVVISIPLTE-TVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDD 1210
            V    LWVGT  GVV+++P +  TV   R  L     + T    G       +  V   D
Sbjct: 1929 VCEELLWVGTSAGVVLTMPTSPGTVSCPRAPL-----SPTGLGQGHTGHVRFLAAVQLPD 1983

Query: 1211 SSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSP-AEGPGPAA 1269
              +    +  P       +L    HR                      DSP   GP PA 
Sbjct: 1984 GFNLLCPTPPPPPDTGPEKLPSLEHR----------------------DSPWHRGPAPAR 2021

Query: 1270 PASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVW 1329
            P           +LV+SGG+GY DFR+  G    +E    D S           +H+++W
Sbjct: 2022 P----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDS----------TNHLLLW 2061

Query: 1330 QV 1331
            +V
Sbjct: 2062 RV 2063


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 1 [Homo sapiens]
          Length = 1279

 Score =  112 bits (280), Expect = 2e-24
 Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)

Query: 915  RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 973
            RP P T   F      P + P    E  PE  + + +R E     DP+   ++  PT+ L
Sbjct: 846  RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 896

Query: 974  GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1031
            G Q+G + ++S+V    +CL S +      VL L H    +L  L DGTLA + R   G 
Sbjct: 897  GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 956

Query: 1032 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1090
             WDL +  +     P   +R +  + D VW     +V V++  T+Q ++SF+AH      
Sbjct: 957  LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 1015

Query: 1091 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1150
            V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L     G   + +T+L
Sbjct: 1016 VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1071

Query: 1151 LVAGSRLWVGTGNGVVISIPL 1171
            L+    LWVGT  GV++ +P+
Sbjct: 1072 LICQGLLWVGTDQGVIVLLPV 1092


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 2 [Homo sapiens]
          Length = 1240

 Score =  112 bits (280), Expect = 2e-24
 Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)

Query: 915  RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 973
            RP P T   F      P + P    E  PE  + + +R E     DP+   ++  PT+ L
Sbjct: 807  RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 857

Query: 974  GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1031
            G Q+G + ++S+V    +CL S +      VL L H    +L  L DGTLA + R   G 
Sbjct: 858  GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 917

Query: 1032 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1090
             WDL +  +     P   +R +  + D VW     +V V++  T+Q ++SF+AH      
Sbjct: 918  LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 976

Query: 1091 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1150
            V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L     G   + +T+L
Sbjct: 977  VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1032

Query: 1151 LVAGSRLWVGTGNGVVISIPL 1171
            L+    LWVGT  GV++ +P+
Sbjct: 1033 LICQGLLWVGTDQGVIVLLPV 1053


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
          Length = 1344

 Score =  102 bits (254), Expect = 2e-21
 Identities = 64/227 (28%), Positives = 110/227 (48%), Gaps = 17/227 (7%)

Query: 952  PEPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKL-------KDSVLS 1004
            P   P  +     +S  PT+ +G + G + ++ +    KK    ++L       K +V+S
Sbjct: 947  PGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMS 1002

Query: 1005 LVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYK 1064
            L      +   L +G +A + R  DG WD     ++ LG     +R + ++ D +W    
Sbjct: 1003 LACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASG 1060

Query: 1065 NKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQD 1124
             +V +I  +T  +E   +AH      +  +A  G G+W++    STLRL+H  T +HLQD
Sbjct: 1061 GQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQD 1120

Query: 1125 VDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPL 1171
            ++I   V  ML     G   + +T+LLV    L VGT  GV++++P+
Sbjct: 1121 INIATPVHNMLP----GHQRLSVTSLLVCHGLLMVGTSLGVLVALPV 1163


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 99/547 (18%), Positives = 224/547 (40%), Gaps = 62/547 (11%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYER----EKALRRQA 104
            E++VKE+  L  + +        +++E + E E+L +  E +  + ER     +A+R++ 
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643

Query: 105  EEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYA----DQISRLEERESEMKKE 160
            +E + +     E  KKE + Q++  E +  +++ K + +A     +I  LEE    ++ E
Sbjct: 1644 QELYGKLRST-EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAE 1702

Query: 161  YNALHQRHTEMIQTYV-------EHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPL 213
             +       E ++T +       E +ER KM+    + + +S +  +        ++   
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762

Query: 214  ADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKS 273
             +G V  Q    L     H + +++ +  + S     +++ S S  +    + S    KS
Sbjct: 1763 IEGNVSKQ--ANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKS 1820

Query: 274  NTPTSSVPSAAVTPLNESLQPLGDY--GVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIG 331
              P  S   ++   +N  LQ +      +     ++ + K  S+ +E +    +  +S  
Sbjct: 1821 ANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTK 1880

Query: 332  MGS---SDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELST 388
             G      E     ++++   + ++   T+L  T                 D L   L  
Sbjct: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE------------EKDDLEERLMN 1928

Query: 389  AGSEVIGDVDEGADLLGEFSVRDDFF-----GMGKEVGNLLLENSQLLETKNAL-NVVKN 442
              +E+ G +      + +  ++++        + K V  L  E  QL++ K  + + ++ 
Sbjct: 1929 QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK 1988

Query: 443  DLIAKVDQLSGE----------QEVLRGELEAAKQAK---VKLENRIKELEEELKRVKSE 489
            + + K+     E          QE+L+ + +  KQ +   ++ + +I  LE  +K ++  
Sbjct: 1989 EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFV 2048

Query: 490  AIIARREPKEEAEDVSSYLCTESDKIPMAQRRRF------TRVEMARVLMERNQYKERLM 543
               ++++ +   E+++     E  K   A+   F      T+ E ARVL +  + K+ L 
Sbjct: 2049 QTESQKDLEITKENLAQ--AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106

Query: 544  ELQEAVR 550
              +E+V+
Sbjct: 2107 SNKESVK 2113



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 110/553 (19%), Positives = 216/553 (39%), Gaps = 76/553 (13%)

Query: 63   LEN-LDSVLSENQEHEVELELLRED-------NEQLLTQYEREKALRRQAEEKFIEFEDA 114
            LEN  +++LS+    + EL++L+E+       N+Q+  +  R   L+  AEE+  + E+ 
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925

Query: 115  LEQEKKELQIQVEHY-------EFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQR 167
            L  +  EL   + +Y       + +   LE + KN    +S LEE + ++ KE   +   
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE-- 1983

Query: 168  HTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLV 227
             +E+ + Y+E I+ +  Q+  GN      L    KE+   +    L    +R Q   K+ 
Sbjct: 1984 -SEIRKEYLEKIQGA--QKEPGNKSHAKELQELLKEKQQEVK--QLQKDCIRYQ--EKIS 2036

Query: 228  PAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTP 287
                     +  Q +S    +  ++ ++++ +    A       K     +   +A V  
Sbjct: 2037 ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA 2096

Query: 288  LNESLQPLGDYGVGS------------------------KNSKRAREKRDS-RNMEVQVT 322
             N  L+        S                        K  K  +EK D+ R  +V + 
Sbjct: 2097 DNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156

Query: 323  QEMRNVSIGMGSSD-EWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDS 381
            + +  + + +   D E   +Q+ +DST    +   T+   +       ++++A     + 
Sbjct: 2157 ETIGEIQVTLNKKDKEVQQLQENLDSTVT-QLAAFTKSMSSLQDDRDRVIDEAK--KWER 2213

Query: 382  LYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNL--LLENSQLLETKNALNV 439
             + +   +  E I   ++   +L +  +R     M +   N+  L  + Q+ E+K    V
Sbjct: 2214 KFSDAIQSKEEEIRLKEDNCSVLKD-QLRQMSIHMEELKINISRLEHDKQIWESKAQTEV 2272

Query: 440  VKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKE 499
                 +   D L GE + L  +LE  +      +N + +LE ELK +           K+
Sbjct: 2273 QLQQKVC--DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-----------KD 2319

Query: 500  EAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR 559
            +  D+S+ L  E  K          R + A +   +  Y++   +LQ +   T     SR
Sbjct: 2320 QLTDLSNSL--EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT-----SR 2372

Query: 560  EHPSVQEKKKSTI 572
             H  +  K++  I
Sbjct: 2373 LHEEINMKEQKII 2385



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 39/170 (22%), Positives = 80/170 (47%), Gaps = 18/170 (10%)

Query: 40  FERLIHCYDEEVVKELMPLVVNV-----LENLDSVLSENQEHEVELELLREDNEQLLTQY 94
           FE  +  +++E+++ +    V       L  L   L E++E  V    + +  +Q LT  
Sbjct: 226 FETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAA 285

Query: 95  E-REKALRRQAEEKFIE---FEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRL 150
           E R + L +Q ++   E     + +E E++E +I +E  E +  + +L   N  +++  L
Sbjct: 286 EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHL 345

Query: 151 EER-------ESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQT 193
            E+       ++E++  Y+AL Q+H   ++    HI    +Q+ G   Q+
Sbjct: 346 LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI--LSLQKTGQELQS 393



 Score = 37.4 bits (85), Expect = 0.097
 Identities = 24/107 (22%), Positives = 51/107 (47%), Gaps = 24/107 (22%)

Query: 65   NLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQI 124
            ++D + SEN + + EL   RED  Q++T                   +D+ +++  E+Q+
Sbjct: 2518 HMDDLNSENAKLDAELIQYREDLNQVIT------------------IKDSQQKQLLEVQL 2559

Query: 125  QVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEM 171
            Q      Q ++LE K     +++   EE   ++++ +NAL +   ++
Sbjct: 2560 Q------QNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDL 2600



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 97/497 (19%), Positives = 205/497 (41%), Gaps = 86/497 (17%)

Query: 59   VVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQE 118
            V  + ENLDS +++       +  L++D ++++ + ++ +           +F DA++ +
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER----------KFSDAIQSK 2222

Query: 119  KKELQIQVEHYEF---QTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTY 175
            ++E++++ ++      Q RQ+ +  +     ISRLE      K+ + +  Q   ++ Q  
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD----KQIWESKAQTEVQLQQKV 2278

Query: 176  VEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHL 235
             + ++       G N +  S L   R    +S N          A++  +L    D   L
Sbjct: 2279 CDTLQ-------GENKELLSQLEETRHLYHSSQNEL--------AKLESELKSLKD--QL 2321

Query: 236  SDLGQLQSSSSYQCPQDEMSESG--QSSAAATPSTTGTKSNTPTSSVPSAAVTP-LNESL 292
            +DL    S+S  +C + + +  G  +   A   ++  +     T    S  +T  L+E +
Sbjct: 2322 TDL----SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377

Query: 293  QPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDV-----QDIIDS 347
                   +   + K    +     +  Q  +E++ +   +   +E + V     +  +D 
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437

Query: 348  TPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSE---VIGD-------- 396
            T +L       ++   +   + I  KA     DS    +S+  ++   ++GD        
Sbjct: 2438 TNQL-------METLKTIKKENIQQKA---QLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487

Query: 397  ---VDEGADLLGEFS-----VRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKV 448
               + E   L+ E +     ++++  G+   + +L  EN++L      L   + DL   +
Sbjct: 2488 LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKL---DAELIQYREDLNQVI 2544

Query: 449  DQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARRE---PKEEAEDVS 505
                 +Q+ L   LE   Q   +LEN+  +LEE+LK  +      RR     +EE +D+S
Sbjct: 2545 TIKDSQQKQL---LEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601

Query: 506  SYLCTESDKIPMAQRRR 522
              +  ES K+ ++Q  R
Sbjct: 2602 KEI--ESLKVSISQLTR 2616



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 13/153 (8%)

Query: 64   ENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEE------KFIEFEDALEQ 117
            E+L   L  +Q     LE LRE   +L    E +K + ++ E+      +  E E AL +
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKL---DELQKLISKKEEDVSYLSGQLSEKEAALTK 1424

Query: 118  EKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL--HQRHTEMIQTY 175
             + E+  Q +  +    QLE++AK + ++I +L+    EMK++   +    R  + IQ  
Sbjct: 1425 IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK 1484

Query: 176  VEH--IERSKMQQVGGNSQTESSLPGRRKERPT 206
            ++   I R +  +   + Q E SL     ER T
Sbjct: 1485 LQAALISRKEALKENKSLQEELSLARGTIERLT 1517



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 30/126 (23%), Positives = 60/126 (47%), Gaps = 8/126 (6%)

Query: 426 ENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELK- 484
           E S++L  K  L V +  L      L  E   L  + E A QA+ +LE+R   LE++ K 
Sbjct: 315 EESKILLEKMELEVAERKL--SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA 372

Query: 485 --RVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLME-RNQYKER 541
               K+  I++ ++  +E +     L  ++ K  + Q +    V+ A+ + +  +Q +++
Sbjct: 373 EMEEKTSHILSLQKTGQELQSACDALKDQNSK--LLQDKNEQAVQSAQTIQQLEDQLQQK 430

Query: 542 LMELQE 547
             E+ +
Sbjct: 431 SKEISQ 436



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 33/173 (19%), Positives = 75/173 (43%), Gaps = 9/173 (5%)

Query: 380  DSLYHELSTAGSEVIGDVDEGADLLGEFSV-RDDFFGMGKEVGNLLLENSQLLETKNALN 438
            + L   L+   S+V     E   +LG  ++ +++   +  E+   LLEN  L  +  +L 
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLK 1573

Query: 439  VVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPK 498
            +        ++ L+ ++E L  E+E+ K +K+      +E  +EL++     + +     
Sbjct: 1574 LA-------LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVS 1626

Query: 499  EEAEDVSSYL-CTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVR 550
             EAE +   +     +K  +  + R T         +  + ++ + E++E +R
Sbjct: 1627 NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR 1679



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 23/87 (26%), Positives = 48/87 (55%), Gaps = 10/87 (11%)

Query: 71   SENQEHEVELELL--REDNEQLLTQYER----EKALRRQAEEKFIEFEDALEQEKKELQI 124
            SE+ + E+E ++L   ++ EQL  + +      KA+ ++A+EK     + L+Q+K +   
Sbjct: 1155 SEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNR 1214

Query: 125  QVEHYEFQTRQLELKAKNYADQISRLE 151
              E ++ Q+++ E    N  DQ+ +L+
Sbjct: 1215 LQEQFDEQSKENE----NIGDQLRQLQ 1237



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 29/163 (17%), Positives = 68/163 (41%), Gaps = 29/163 (17%)

Query: 54   ELMPLVVNVLENLDSVLSENQEHEVELE-----LLREDNEQLLTQYEREKALRRQAEEKF 108
            E + + ++ LE+   +     + EV+L+      L+ +N++LL+Q E  + L   ++ + 
Sbjct: 2248 EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNEL 2307

Query: 109  IEFEDALEQEKKEL------------------------QIQVEHYEFQTRQLELKAKNYA 144
             + E  L+  K +L                        +  +++ +F   QLE   +   
Sbjct: 2308 AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR 2367

Query: 145  DQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQV 187
            +  SRL E  +  +++  +L     E IQ  +  + +   +++
Sbjct: 2368 ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI 2410



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 13/110 (11%)

Query: 45   HCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYER-EKALRRQ 103
            +C D    +    L+ + ++NL   +SE          L E+ +QL+ +  + E  +R++
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSE----------LEEEKQQLVKEKTKVESEIRKE 1989

Query: 104  AEEKF--IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLE 151
              EK    + E   +   KELQ  ++  + + +QL+     Y ++IS LE
Sbjct: 1990 YLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALE 2039


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 97/480 (20%), Positives = 191/480 (39%), Gaps = 53/480 (11%)

Query: 76   HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
            HE+E  L  E++     Q ER+K       ++ ++ E+ LE+E+   Q      + +   
Sbjct: 925  HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 975

Query: 136  LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
             E K K   D+I  ++++ +++ KE   L +R +++     E  E++K      N     
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035

Query: 195  -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
             S L  R K+   S          ++ ++ G    A D H  ++DL    +    Q  + 
Sbjct: 1036 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1088

Query: 253  EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
            E  E  Q++ A        K+N         A+  + E    + D      + + AR K 
Sbjct: 1089 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1137

Query: 313  DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
            + +  ++    E              ++++D +DST       E R  R        ++ 
Sbjct: 1138 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1180

Query: 373  KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLE 432
            KA    T S   ++     +    V+E  + L +F  +     + K    L  EN+ L  
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNKQTLEKENADLAG 1238

Query: 433  TKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAII 492
                L   K ++  K  +L  + + L+ +    ++A+ +L +++ +L+ E++ V      
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 493  ARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 548
            A  +  + A+DV+S      D   + Q     ++ ++  L     ERN  +++L E  EA
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 99/543 (18%), Positives = 212/543 (39%), Gaps = 54/543 (9%)

Query: 63   LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
            L  LD  +++      ++  L      L    + E+A R +AE++  +  + LE  K EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 123  QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
            +   +  +    Q EL+AK   +       L+E     + +   + Q+H + ++   E +
Sbjct: 1156 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212

Query: 180  ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
            E+ K  +     + + +L     +    L V     G  + ++  K          + + 
Sbjct: 1213 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1262

Query: 240  QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
            +LQS  S  +  + E+++          S TG  +     ++  A  V  L+  LQ   +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322

Query: 298  YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
                    K     + R+  + RN ++ Q+ +EM       R++S + +  SD    +QD
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382

Query: 344  IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
               +   L+   + R  +   + TQ    KA   +  +   + L     +++ D+D    
Sbjct: 1383 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 403  LLGEFSVR----DDFFGMGKEVGNLLLENSQLLETK------NALNVVK--NDLIAKVDQ 450
            L+     +    D      K + +   +     E +       AL++ +   + +   ++
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 451  LSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL-C 509
            L    ++L+ E+E    +K  +   + ELE+  + ++++      E K + E++   L  
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQA 1557

Query: 510  TESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQE 566
            TE  K+ +    +  + +  R L    E+N+ K R ++ Q     TE+    ++      
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617

Query: 567  KKK 569
             KK
Sbjct: 1618 AKK 1620



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)

Query: 61   NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
            N +E++  +L+E +   ++L           +D ++LL +  R+K       RQ EE+  
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346

Query: 110  EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
              +D L++E   K+ L+  +     Q    + K +++A  +  LEE +   +KE   L Q
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406

Query: 167  RHTEMIQTYVEHIERSK 183
            ++ E    Y + +E++K
Sbjct: 1407 QYEEKAAAY-DKLEKTK 1422



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 99/448 (22%), Positives = 176/448 (39%), Gaps = 58/448 (12%)

Query: 67   DSVLSENQEHEVE-LELLREDNEQLLTQYERE---KALRRQAEEKFIEFEDA------LE 116
            D   +E +E E + L L R   E L  + E E   K L+ + E+     +D       LE
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1531

Query: 117  QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYV 176
            + K+ L+ Q+E  + Q  +LE       D++   E+ +  ++    AL  +    +Q   
Sbjct: 1532 KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQFERDLQARD 1584

Query: 177  EHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVR-AQIGGKLVPAGDHWHL 235
            E  E  + Q      + E+ L   RK+R  +       +G ++  ++       G    +
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 236  SDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPL 295
              L +LQ+       +D   E   + A+        K N   +    A +  L E L   
Sbjct: 1645 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA- 1698

Query: 296  GDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGS-SDEWSDVQDIIDSTPELDMC 354
                     ++RAR++ D    E  + +E+ +   G  +  DE   ++  I    E    
Sbjct: 1699 ---------AERARKQADLEKEE--LAEELASSLSGRNALQDEKRRLEARIAQLEE---- 1743

Query: 355  PETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFF 414
             E   ++         V KA     + L +EL+T          E +      S R    
Sbjct: 1744 -ELEEEQGNMEAMSDRVRKATQ-QAEQLSNELAT----------ERSTAQKNESARQQLE 1791

Query: 415  GMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLEN 474
               KE+ + L E    +++K    +    L AK+ QL  + E    E +AA ++   L+ 
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS---LKQ 1846

Query: 475  RIKELEEELKRVKSEAIIARREPKEEAE 502
            + K+L+E L +V+ E  +A  + KE+AE
Sbjct: 1847 KDKKLKEILLQVEDERKMA-EQYKEQAE 1873



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 101/543 (18%), Positives = 214/543 (39%), Gaps = 65/543 (11%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            EE  K     + N+ +  +   +   + E     L+++ + L+   + ++ L    E+K 
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450

Query: 109  IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
             +F+  L +EK    +   + +  E + R+ E KA + A  +    E + E+        
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1502

Query: 166  QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
            +R  +M++  +E +  SK   VG N     +++ +L  + +E  T L           D 
Sbjct: 1503 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 217  TVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTP 276
             +R ++  + +           GQ +     +  Q+E  +  Q         T  +    
Sbjct: 1562 KLRLEVNMQALK----------GQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERK 1610

Query: 277  TSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSD 336
              ++ +AA   L   L+ L +    S    R    +  R ++ Q+    R +     S D
Sbjct: 1611 QRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 337  E-WSDVQDIIDSTPELDM-CPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVI 394
            E ++  ++       L+    + + D   +   +    K   +  + L  EL+++ S   
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1725

Query: 395  GDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD----- 449
               DE   L    +  ++   + +E GN+   + ++ +       + N+L  +       
Sbjct: 1726 ALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 450  -----QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARRE 496
                 QL  + + LR    E+E A ++K K     LE +I +LEE++++   E   A + 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 497  PKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIR 556
             K++ + +   L    D+  MA++ +    E A       + K+   +L+EA   ++ I 
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRIN 1897

Query: 557  ASR 559
            A+R
Sbjct: 1898 ANR 1900



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)

Query: 445 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 498
           + +V +   E +    EL+  K+ + K EN +KELE+      E K +  E + A  E  
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 499 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 553
            EAE++   L  +  ++         R+E       ++  ER +  +++++L+E +   E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 554 MIRASREHPSVQEKKK 569
             R   +   V  + K
Sbjct: 964 AARQKLQLEKVTAEAK 979



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)

Query: 48   DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
            +E+  K L   ++ + E+L +     ++ ++E E L E+    L+     +  +R+ E +
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737

Query: 108  FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
              + E+ LE+E+  ++   +     T+Q E  +   A + S  ++ ES   +++++   L
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797

Query: 165  HQRHTEM 171
              +  EM
Sbjct: 1798 RSKLHEM 1804



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 72   ENQEHEVELELLREDNEQLLTQY--EREKA-----LRRQAEEKFIEFEDALEQEKKELQI 124
            +N +   E +LL E    L T    E EKA     L+ + E    E E  L++E+K  Q 
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ- 1051

Query: 125  QVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE 160
                 E   R+LE  A ++ +QI+ L+ + +E+K +
Sbjct: 1052 ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)

Query: 27   ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
            ER +    S   E E  +    +  +  L   +  + E ++    E Q     L+   + 
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 87   NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
             +++L Q E E+ +  Q +E+     +      K+L+ Q+E  E +++++    +    +
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906

Query: 147  ISRLEERESEMKKEYNALHQR 167
            +    E    M +E NAL  +
Sbjct: 1907 LDEATESNEAMGREVNALKSK 1927



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)

Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
           F + +  L+  ++E ++Q +  E Q T++ + KA+N   ++  LE++ S++ +E N L +
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894

Query: 167 RHTEMIQTYVE 177
           +     + Y E
Sbjct: 895 QLQAETELYAE 905


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 97/480 (20%), Positives = 191/480 (39%), Gaps = 53/480 (11%)

Query: 76   HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
            HE+E  L  E++     Q ER+K       ++ ++ E+ LE+E+   Q      + +   
Sbjct: 932  HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 982

Query: 136  LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
             E K K   D+I  ++++ +++ KE   L +R +++     E  E++K      N     
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042

Query: 195  -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
             S L  R K+   S          ++ ++ G    A D H  ++DL    +    Q  + 
Sbjct: 1043 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1095

Query: 253  EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
            E  E  Q++ A        K+N         A+  + E    + D      + + AR K 
Sbjct: 1096 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1144

Query: 313  DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
            + +  ++    E              ++++D +DST       E R  R        ++ 
Sbjct: 1145 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1187

Query: 373  KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLE 432
            KA    T S   ++     +    V+E  + L +F  +     + K    L  EN+ L  
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNKQTLEKENADLAG 1245

Query: 433  TKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAII 492
                L   K ++  K  +L  + + L+ +    ++A+ +L +++ +L+ E++ V      
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 493  ARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 548
            A  +  + A+DV+S      D   + Q     ++ ++  L     ERN  +++L E  EA
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 99/543 (18%), Positives = 212/543 (39%), Gaps = 54/543 (9%)

Query: 63   LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
            L  LD  +++      ++  L      L    + E+A R +AE++  +  + LE  K EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 123  QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
            +   +  +    Q EL+AK   +       L+E     + +   + Q+H + ++   E +
Sbjct: 1163 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219

Query: 180  ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
            E+ K  +     + + +L     +    L V     G  + ++  K          + + 
Sbjct: 1220 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1269

Query: 240  QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
            +LQS  S  +  + E+++          S TG  +     ++  A  V  L+  LQ   +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 298  YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
                    K     + R+  + RN ++ Q+ +EM       R++S + +  SD    +QD
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389

Query: 344  IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
               +   L+   + R  +   + TQ    KA   +  +   + L     +++ D+D    
Sbjct: 1390 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 403  LLGEFSVR----DDFFGMGKEVGNLLLENSQLLETK------NALNVVK--NDLIAKVDQ 450
            L+     +    D      K + +   +     E +       AL++ +   + +   ++
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508

Query: 451  LSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL-C 509
            L    ++L+ E+E    +K  +   + ELE+  + ++++      E K + E++   L  
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQA 1564

Query: 510  TESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQE 566
            TE  K+ +    +  + +  R L    E+N+ K R ++ Q     TE+    ++      
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624

Query: 567  KKK 569
             KK
Sbjct: 1625 AKK 1627



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)

Query: 61   NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
            N +E++  +L+E +   ++L           +D ++LL +  R+K       RQ EE+  
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353

Query: 110  EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
              +D L++E   K+ L+  +     Q    + K +++A  +  LEE +   +KE   L Q
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413

Query: 167  RHTEMIQTYVEHIERSK 183
            ++ E    Y + +E++K
Sbjct: 1414 QYEEKAAAY-DKLEKTK 1429



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 99/448 (22%), Positives = 176/448 (39%), Gaps = 58/448 (12%)

Query: 67   DSVLSENQEHEVE-LELLREDNEQLLTQYERE---KALRRQAEEKFIEFEDA------LE 116
            D   +E +E E + L L R   E L  + E E   K L+ + E+     +D       LE
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538

Query: 117  QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYV 176
            + K+ L+ Q+E  + Q  +LE       D++   E+ +  ++    AL  +    +Q   
Sbjct: 1539 KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQFERDLQARD 1591

Query: 177  EHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVR-AQIGGKLVPAGDHWHL 235
            E  E  + Q      + E+ L   RK+R  +       +G ++  ++       G    +
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 236  SDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPL 295
              L +LQ+       +D   E   + A+        K N   +    A +  L E L   
Sbjct: 1652 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA- 1705

Query: 296  GDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGS-SDEWSDVQDIIDSTPELDMC 354
                     ++RAR++ D    E  + +E+ +   G  +  DE   ++  I    E    
Sbjct: 1706 ---------AERARKQADLEKEE--LAEELASSLSGRNALQDEKRRLEARIAQLEE---- 1750

Query: 355  PETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFF 414
             E   ++         V KA     + L +EL+T          E +      S R    
Sbjct: 1751 -ELEEEQGNMEAMSDRVRKATQ-QAEQLSNELAT----------ERSTAQKNESARQQLE 1798

Query: 415  GMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLEN 474
               KE+ + L E    +++K    +    L AK+ QL  + E    E +AA ++   L+ 
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS---LKQ 1853

Query: 475  RIKELEEELKRVKSEAIIARREPKEEAE 502
            + K+L+E L +V+ E  +A  + KE+AE
Sbjct: 1854 KDKKLKEILLQVEDERKMA-EQYKEQAE 1880



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 101/543 (18%), Positives = 214/543 (39%), Gaps = 65/543 (11%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            EE  K     + N+ +  +   +   + E     L+++ + L+   + ++ L    E+K 
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457

Query: 109  IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
             +F+  L +EK    +   + +  E + R+ E KA + A  +    E + E+        
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1509

Query: 166  QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
            +R  +M++  +E +  SK   VG N     +++ +L  + +E  T L           D 
Sbjct: 1510 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 217  TVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTP 276
             +R ++  + +           GQ +     +  Q+E  +  Q         T  +    
Sbjct: 1569 KLRLEVNMQALK----------GQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERK 1617

Query: 277  TSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSD 336
              ++ +AA   L   L+ L +    S    R    +  R ++ Q+    R +     S D
Sbjct: 1618 QRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 337  E-WSDVQDIIDSTPELDM-CPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVI 394
            E ++  ++       L+    + + D   +   +    K   +  + L  EL+++ S   
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1732

Query: 395  GDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD----- 449
               DE   L    +  ++   + +E GN+   + ++ +       + N+L  +       
Sbjct: 1733 ALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 450  -----QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARRE 496
                 QL  + + LR    E+E A ++K K     LE +I +LEE++++   E   A + 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 497  PKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIR 556
             K++ + +   L    D+  MA++ +    E A       + K+   +L+EA   ++ I 
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRIN 1904

Query: 557  ASR 559
            A+R
Sbjct: 1905 ANR 1907



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)

Query: 445 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 498
           + +V +   E +    EL+  K+ + K EN +KELE+      E K +  E + A  E  
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 499 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 553
            EAE++   L  +  ++         R+E       ++  ER +  +++++L+E +   E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 554 MIRASREHPSVQEKKK 569
             R   +   V  + K
Sbjct: 971 AARQKLQLEKVTAEAK 986



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)

Query: 48   DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
            +E+  K L   ++ + E+L +     ++ ++E E L E+    L+     +  +R+ E +
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744

Query: 108  FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
              + E+ LE+E+  ++   +     T+Q E  +   A + S  ++ ES   +++++   L
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804

Query: 165  HQRHTEM 171
              +  EM
Sbjct: 1805 RSKLHEM 1811



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 72   ENQEHEVELELLREDNEQLLTQY--EREKA-----LRRQAEEKFIEFEDALEQEKKELQI 124
            +N +   E +LL E    L T    E EKA     L+ + E    E E  L++E+K  Q 
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ- 1058

Query: 125  QVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE 160
                 E   R+LE  A ++ +QI+ L+ + +E+K +
Sbjct: 1059 ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)

Query: 27   ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
            ER +    S   E E  +    +  +  L   +  + E ++    E Q     L+   + 
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 87   NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
             +++L Q E E+ +  Q +E+     +      K+L+ Q+E  E +++++    +    +
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913

Query: 147  ISRLEERESEMKKEYNALHQR 167
            +    E    M +E NAL  +
Sbjct: 1914 LDEATESNEAMGREVNALKSK 1934



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)

Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
           F + +  L+  ++E ++Q +  E Q T++ + KA+N   ++  LE++ S++ +E N L +
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901

Query: 167 RHTEMIQTYVE 177
           +     + Y E
Sbjct: 902 QLQAETELYAE 912


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 97/480 (20%), Positives = 191/480 (39%), Gaps = 53/480 (11%)

Query: 76   HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
            HE+E  L  E++     Q ER+K       ++ ++ E+ LE+E+   Q      + +   
Sbjct: 932  HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 982

Query: 136  LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
             E K K   D+I  ++++ +++ KE   L +R +++     E  E++K      N     
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042

Query: 195  -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
             S L  R K+   S          ++ ++ G    A D H  ++DL    +    Q  + 
Sbjct: 1043 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1095

Query: 253  EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
            E  E  Q++ A        K+N         A+  + E    + D      + + AR K 
Sbjct: 1096 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1144

Query: 313  DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
            + +  ++    E              ++++D +DST       E R  R        ++ 
Sbjct: 1145 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1187

Query: 373  KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLE 432
            KA    T S   ++     +    V+E  + L +F  +     + K    L  EN+ L  
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNKQTLEKENADLAG 1245

Query: 433  TKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAII 492
                L   K ++  K  +L  + + L+ +    ++A+ +L +++ +L+ E++ V      
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 493  ARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 548
            A  +  + A+DV+S      D   + Q     ++ ++  L     ERN  +++L E  EA
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 99/543 (18%), Positives = 212/543 (39%), Gaps = 54/543 (9%)

Query: 63   LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
            L  LD  +++      ++  L      L    + E+A R +AE++  +  + LE  K EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 123  QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
            +   +  +    Q EL+AK   +       L+E     + +   + Q+H + ++   E +
Sbjct: 1163 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219

Query: 180  ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
            E+ K  +     + + +L     +    L V     G  + ++  K          + + 
Sbjct: 1220 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1269

Query: 240  QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
            +LQS  S  +  + E+++          S TG  +     ++  A  V  L+  LQ   +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329

Query: 298  YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
                    K     + R+  + RN ++ Q+ +EM       R++S + +  SD    +QD
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389

Query: 344  IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
               +   L+   + R  +   + TQ    KA   +  +   + L     +++ D+D    
Sbjct: 1390 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 403  LLGEFSVR----DDFFGMGKEVGNLLLENSQLLETK------NALNVVK--NDLIAKVDQ 450
            L+     +    D      K + +   +     E +       AL++ +   + +   ++
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508

Query: 451  LSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL-C 509
            L    ++L+ E+E    +K  +   + ELE+  + ++++      E K + E++   L  
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQA 1564

Query: 510  TESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQE 566
            TE  K+ +    +  + +  R L    E+N+ K R ++ Q     TE+    ++      
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624

Query: 567  KKK 569
             KK
Sbjct: 1625 AKK 1627



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)

Query: 61   NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
            N +E++  +L+E +   ++L           +D ++LL +  R+K       RQ EE+  
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353

Query: 110  EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
              +D L++E   K+ L+  +     Q    + K +++A  +  LEE +   +KE   L Q
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413

Query: 167  RHTEMIQTYVEHIERSK 183
            ++ E    Y + +E++K
Sbjct: 1414 QYEEKAAAY-DKLEKTK 1429



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 99/448 (22%), Positives = 176/448 (39%), Gaps = 58/448 (12%)

Query: 67   DSVLSENQEHEVE-LELLREDNEQLLTQYERE---KALRRQAEEKFIEFEDA------LE 116
            D   +E +E E + L L R   E L  + E E   K L+ + E+     +D       LE
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538

Query: 117  QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYV 176
            + K+ L+ Q+E  + Q  +LE       D++   E+ +  ++    AL  +    +Q   
Sbjct: 1539 KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQFERDLQARD 1591

Query: 177  EHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVR-AQIGGKLVPAGDHWHL 235
            E  E  + Q      + E+ L   RK+R  +       +G ++  ++       G    +
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 236  SDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPL 295
              L +LQ+       +D   E   + A+        K N   +    A +  L E L   
Sbjct: 1652 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA- 1705

Query: 296  GDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGS-SDEWSDVQDIIDSTPELDMC 354
                     ++RAR++ D    E  + +E+ +   G  +  DE   ++  I    E    
Sbjct: 1706 ---------AERARKQADLEKEE--LAEELASSLSGRNALQDEKRRLEARIAQLEE---- 1750

Query: 355  PETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFF 414
             E   ++         V KA     + L +EL+T          E +      S R    
Sbjct: 1751 -ELEEEQGNMEAMSDRVRKATQ-QAEQLSNELAT----------ERSTAQKNESARQQLE 1798

Query: 415  GMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLEN 474
               KE+ + L E    +++K    +    L AK+ QL  + E    E +AA ++   L+ 
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS---LKQ 1853

Query: 475  RIKELEEELKRVKSEAIIARREPKEEAE 502
            + K+L+E L +V+ E  +A  + KE+AE
Sbjct: 1854 KDKKLKEILLQVEDERKMA-EQYKEQAE 1880



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 101/543 (18%), Positives = 214/543 (39%), Gaps = 65/543 (11%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            EE  K     + N+ +  +   +   + E     L+++ + L+   + ++ L    E+K 
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457

Query: 109  IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
             +F+  L +EK    +   + +  E + R+ E KA + A  +    E + E+        
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1509

Query: 166  QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
            +R  +M++  +E +  SK   VG N     +++ +L  + +E  T L           D 
Sbjct: 1510 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 217  TVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTP 276
             +R ++  + +           GQ +     +  Q+E  +  Q         T  +    
Sbjct: 1569 KLRLEVNMQALK----------GQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERK 1617

Query: 277  TSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSD 336
              ++ +AA   L   L+ L +    S    R    +  R ++ Q+    R +     S D
Sbjct: 1618 QRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 337  E-WSDVQDIIDSTPELDM-CPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVI 394
            E ++  ++       L+    + + D   +   +    K   +  + L  EL+++ S   
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1732

Query: 395  GDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD----- 449
               DE   L    +  ++   + +E GN+   + ++ +       + N+L  +       
Sbjct: 1733 ALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 450  -----QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARRE 496
                 QL  + + LR    E+E A ++K K     LE +I +LEE++++   E   A + 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 497  PKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIR 556
             K++ + +   L    D+  MA++ +    E A       + K+   +L+EA   ++ I 
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRIN 1904

Query: 557  ASR 559
            A+R
Sbjct: 1905 ANR 1907



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)

Query: 445 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 498
           + +V +   E +    EL+  K+ + K EN +KELE+      E K +  E + A  E  
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 499 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 553
            EAE++   L  +  ++         R+E       ++  ER +  +++++L+E +   E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 554 MIRASREHPSVQEKKK 569
             R   +   V  + K
Sbjct: 971 AARQKLQLEKVTAEAK 986



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)

Query: 48   DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
            +E+  K L   ++ + E+L +     ++ ++E E L E+    L+     +  +R+ E +
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744

Query: 108  FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
              + E+ LE+E+  ++   +     T+Q E  +   A + S  ++ ES   +++++   L
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804

Query: 165  HQRHTEM 171
              +  EM
Sbjct: 1805 RSKLHEM 1811



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 72   ENQEHEVELELLREDNEQLLTQY--EREKA-----LRRQAEEKFIEFEDALEQEKKELQI 124
            +N +   E +LL E    L T    E EKA     L+ + E    E E  L++E+K  Q 
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ- 1058

Query: 125  QVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE 160
                 E   R+LE  A ++ +QI+ L+ + +E+K +
Sbjct: 1059 ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)

Query: 27   ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
            ER +    S   E E  +    +  +  L   +  + E ++    E Q     L+   + 
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 87   NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
             +++L Q E E+ +  Q +E+     +      K+L+ Q+E  E +++++    +    +
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913

Query: 147  ISRLEERESEMKKEYNALHQR 167
            +    E    M +E NAL  +
Sbjct: 1914 LDEATESNEAMGREVNALKSK 1934



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)

Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
           F + +  L+  ++E ++Q +  E Q T++ + KA+N   ++  LE++ S++ +E N L +
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901

Query: 167 RHTEMIQTYVE 177
           +     + Y E
Sbjct: 902 QLQAETELYAE 912


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 97/480 (20%), Positives = 191/480 (39%), Gaps = 53/480 (11%)

Query: 76   HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
            HE+E  L  E++     Q ER+K       ++ ++ E+ LE+E+   Q      + +   
Sbjct: 925  HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 975

Query: 136  LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
             E K K   D+I  ++++ +++ KE   L +R +++     E  E++K      N     
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035

Query: 195  -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
             S L  R K+   S          ++ ++ G    A D H  ++DL    +    Q  + 
Sbjct: 1036 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1088

Query: 253  EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
            E  E  Q++ A        K+N         A+  + E    + D      + + AR K 
Sbjct: 1089 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1137

Query: 313  DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
            + +  ++    E              ++++D +DST       E R  R        ++ 
Sbjct: 1138 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1180

Query: 373  KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLE 432
            KA    T S   ++     +    V+E  + L +F  +     + K    L  EN+ L  
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAKANLDKNKQTLEKENADLAG 1238

Query: 433  TKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAII 492
                L   K ++  K  +L  + + L+ +    ++A+ +L +++ +L+ E++ V      
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 493  ARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 548
            A  +  + A+DV+S      D   + Q     ++ ++  L     ERN  +++L E  EA
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 99/543 (18%), Positives = 212/543 (39%), Gaps = 54/543 (9%)

Query: 63   LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
            L  LD  +++      ++  L      L    + E+A R +AE++  +  + LE  K EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 123  QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
            +   +  +    Q EL+AK   +       L+E     + +   + Q+H + ++   E +
Sbjct: 1156 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212

Query: 180  ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
            E+ K  +     + + +L     +    L V     G  + ++  K          + + 
Sbjct: 1213 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1262

Query: 240  QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
            +LQS  S  +  + E+++          S TG  +     ++  A  V  L+  LQ   +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322

Query: 298  YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
                    K     + R+  + RN ++ Q+ +EM       R++S + +  SD    +QD
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382

Query: 344  IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
               +   L+   + R  +   + TQ    KA   +  +   + L     +++ D+D    
Sbjct: 1383 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 403  LLGEFSVR----DDFFGMGKEVGNLLLENSQLLETK------NALNVVK--NDLIAKVDQ 450
            L+     +    D      K + +   +     E +       AL++ +   + +   ++
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 451  LSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL-C 509
            L    ++L+ E+E    +K  +   + ELE+  + ++++      E K + E++   L  
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQA 1557

Query: 510  TESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQE 566
            TE  K+ +    +  + +  R L    E+N+ K R ++ Q     TE+    ++      
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617

Query: 567  KKK 569
             KK
Sbjct: 1618 AKK 1620



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)

Query: 61   NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
            N +E++  +L+E +   ++L           +D ++LL +  R+K       RQ EE+  
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346

Query: 110  EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
              +D L++E   K+ L+  +     Q    + K +++A  +  LEE +   +KE   L Q
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406

Query: 167  RHTEMIQTYVEHIERSK 183
            ++ E    Y + +E++K
Sbjct: 1407 QYEEKAAAY-DKLEKTK 1422



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 99/448 (22%), Positives = 176/448 (39%), Gaps = 58/448 (12%)

Query: 67   DSVLSENQEHEVE-LELLREDNEQLLTQYERE---KALRRQAEEKFIEFEDA------LE 116
            D   +E +E E + L L R   E L  + E E   K L+ + E+     +D       LE
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1531

Query: 117  QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYV 176
            + K+ L+ Q+E  + Q  +LE       D++   E+ +  ++    AL  +    +Q   
Sbjct: 1532 KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQFERDLQARD 1584

Query: 177  EHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVR-AQIGGKLVPAGDHWHL 235
            E  E  + Q      + E+ L   RK+R  +       +G ++  ++       G    +
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 236  SDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPL 295
              L +LQ+       +D   E   + A+        K N   +    A +  L E L   
Sbjct: 1645 KQLRKLQAQM-----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA- 1698

Query: 296  GDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGS-SDEWSDVQDIIDSTPELDMC 354
                     ++RAR++ D    E  + +E+ +   G  +  DE   ++  I    E    
Sbjct: 1699 ---------AERARKQADLEKEE--LAEELASSLSGRNALQDEKRRLEARIAQLEE---- 1743

Query: 355  PETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFF 414
             E   ++         V KA     + L +EL+T          E +      S R    
Sbjct: 1744 -ELEEEQGNMEAMSDRVRKATQ-QAEQLSNELAT----------ERSTAQKNESARQQLE 1791

Query: 415  GMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLEN 474
               KE+ + L E    +++K    +    L AK+ QL  + E    E +AA ++   L+ 
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS---LKQ 1846

Query: 475  RIKELEEELKRVKSEAIIARREPKEEAE 502
            + K+L+E L +V+ E  +A  + KE+AE
Sbjct: 1847 KDKKLKEILLQVEDERKMA-EQYKEQAE 1873



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 101/543 (18%), Positives = 214/543 (39%), Gaps = 65/543 (11%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            EE  K     + N+ +  +   +   + E     L+++ + L+   + ++ L    E+K 
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450

Query: 109  IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
             +F+  L +EK    +   + +  E + R+ E KA + A  +    E + E+        
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1502

Query: 166  QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
            +R  +M++  +E +  SK   VG N     +++ +L  + +E  T L           D 
Sbjct: 1503 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 217  TVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTP 276
             +R ++  + +           GQ +     +  Q+E  +  Q         T  +    
Sbjct: 1562 KLRLEVNMQALK----------GQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERK 1610

Query: 277  TSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSD 336
              ++ +AA   L   L+ L +    S    R    +  R ++ Q+    R +     S D
Sbjct: 1611 QRALAAAAKKKLEGDLKDL-ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 337  E-WSDVQDIIDSTPELDM-CPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVI 394
            E ++  ++       L+    + + D   +   +    K   +  + L  EL+++ S   
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERAR----KQADLEKEELAEELASSLSGRN 1725

Query: 395  GDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD----- 449
               DE   L    +  ++   + +E GN+   + ++ +       + N+L  +       
Sbjct: 1726 ALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 450  -----QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARRE 496
                 QL  + + LR    E+E A ++K K     LE +I +LEE++++   E   A + 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 497  PKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIR 556
             K++ + +   L    D+  MA++ +    E A       + K+   +L+EA   ++ I 
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRIN 1897

Query: 557  ASR 559
            A+R
Sbjct: 1898 ANR 1900



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)

Query: 445 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 498
           + +V +   E +    EL+  K+ + K EN +KELE+      E K +  E + A  E  
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 499 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 553
            EAE++   L  +  ++         R+E       ++  ER +  +++++L+E +   E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 554 MIRASREHPSVQEKKK 569
             R   +   V  + K
Sbjct: 964 AARQKLQLEKVTAEAK 979



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)

Query: 48   DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
            +E+  K L   ++ + E+L +     ++ ++E E L E+    L+     +  +R+ E +
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737

Query: 108  FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
              + E+ LE+E+  ++   +     T+Q E  +   A + S  ++ ES   +++++   L
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797

Query: 165  HQRHTEM 171
              +  EM
Sbjct: 1798 RSKLHEM 1804



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 72   ENQEHEVELELLREDNEQLLTQY--EREKA-----LRRQAEEKFIEFEDALEQEKKELQI 124
            +N +   E +LL E    L T    E EKA     L+ + E    E E  L++E+K  Q 
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ- 1051

Query: 125  QVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE 160
                 E   R+LE  A ++ +QI+ L+ + +E+K +
Sbjct: 1052 ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)

Query: 27   ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
            ER +    S   E E  +    +  +  L   +  + E ++    E Q     L+   + 
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 87   NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
             +++L Q E E+ +  Q +E+     +      K+L+ Q+E  E +++++    +    +
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906

Query: 147  ISRLEERESEMKKEYNALHQR 167
            +    E    M +E NAL  +
Sbjct: 1907 LDEATESNEAMGREVNALKSK 1927



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)

Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
           F + +  L+  ++E ++Q +  E Q T++ + KA+N   ++  LE++ S++ +E N L +
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894

Query: 167 RHTEMIQTYVE 177
           +     + Y E
Sbjct: 895 QLQAETELYAE 905


>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
          Length = 872

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 37/174 (21%), Positives = 88/174 (50%), Gaps = 9/174 (5%)

Query: 12  VVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLS 71
           ++  +++  + + + E+ SGL+   +     L+  + EEV KE   L+  V++  +S L+
Sbjct: 120 ILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLR-FKEEVTKERDQLLSEVVKLRES-LA 177

Query: 72  ENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEF 131
           +  E + E E  +E+ E  ++Q+++E   R+    +    ++ LE+E K++Q  ++  + 
Sbjct: 178 QTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQT 237

Query: 132 QTRQLELKAKNYADQISRLEERESEMK-------KEYNALHQRHTEMIQTYVEH 178
           + + L+   +   +++ +LE++  E K       KE      R+ ++ Q   +H
Sbjct: 238 EIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQH 291



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 44/167 (26%), Positives = 84/167 (50%), Gaps = 19/167 (11%)

Query: 38  REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYERE 97
           REF +      E++ KEL      +  ++DS  +E +  +  ++  +E+ ++L  Q + +
Sbjct: 213 REFRK-----KEKLEKELK----QIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQ 263

Query: 98  KALRRQAEEKFIEFE---DALEQEKKELQIQVEHY--EFQTRQLELKAKNYADQISRLEE 152
           K L  +A ++  +F+     L+QE ++  +  E    E Q + LELKAK   +++ ++  
Sbjct: 264 KILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKE--EEVHQMRL 321

Query: 153 RESEMKKEYNALHQR--HTEMIQTYVE-HIERSKMQQVGGNSQTESS 196
              ++ K    +H++  HTE  +  VE H E  K Q VG   + E+S
Sbjct: 322 DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEAS 368



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 27/117 (23%), Positives = 55/117 (47%), Gaps = 8/117 (6%)

Query: 59  VVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRR--QAEEKFIEFEDALE 116
           ++  +  L   L    E  VE ELL ++ E+L  + +   A +   +A E+   +   L 
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785

Query: 117 QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQ 173
            +K++L++       +    E+++K Y  ++ +L      +KK+Y  L Q+  E +Q
Sbjct: 786 DKKQQLKV----LSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY--LAQKRKEQLQ 836



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 30/147 (20%), Positives = 72/147 (48%), Gaps = 12/147 (8%)

Query: 410 RDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAK 469
           +D+   M +++  ++ +  +L E  +A       L  +  ++  E+E L+ EL+  +Q  
Sbjct: 509 QDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQA 568

Query: 470 VKLENRIKELEEE---LKRVKSEAIIARREPKEEAEDV-------SSYLCTESDKIPMAQ 519
           ++ ++ I++ E E   L R+ +EA   R   K+E + V        S L   +D++ +  
Sbjct: 569 LETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLY 628

Query: 520 RRRFTRVEMARVLMERNQYKERLMELQ 546
            +   +++ + +    +QY +RL +++
Sbjct: 629 EK--IKIQQSVLNKGESQYNQRLEDMR 653



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 33/167 (19%), Positives = 79/167 (47%), Gaps = 20/167 (11%)

Query: 29  VSGLAGSIYREFERLIHCYD-EEVVKELMPLVVNVLENLDSVLSENQ-----EHEVELEL 82
           ++ L   I + ++ +   YD E+  KE +  +   + NL  ++ +       +H    +L
Sbjct: 92  IASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL 151

Query: 83  LR------EDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL 136
           LR      ++ +QLL++  + +    Q  E+    +   E+ K+E +  +  ++ + +Q 
Sbjct: 152 LRFKEEVTKERDQLLSEVVKLRESLAQTTEQ----QQETERSKEEAEHAISQFQQEIQQR 207

Query: 137 ELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
           + +A     +  + E+ E E+K+    +  R TE I+   +++++SK
Sbjct: 208 QNEASR---EFRKKEKLEKELKQIQADMDSRQTE-IKALQQYVQKSK 250



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 27/125 (21%), Positives = 60/125 (48%), Gaps = 13/125 (10%)

Query: 72  ENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFE----DALEQEKKELQIQVE 127
           EN++H +  E L ++N+Q        KAL  +A+E+ +         L + ++++  ++ 
Sbjct: 287 ENEQHSLVCEQLSQENQQ--------KALELKAKEEEVHQMRLDIGKLNKIREQIHKKLH 338

Query: 128 HYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQV 187
           H E Q  ++E   +   +QI  L ERE E  K+   L ++  + +    + + ++ ++ V
Sbjct: 339 HTEDQKAEVEQHKETLKNQIVGL-EREVEASKKQAELDRKAMDELLRERDILNKNMLKAV 397

Query: 188 GGNSQ 192
               +
Sbjct: 398 NATQK 402



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 28/140 (20%), Positives = 67/140 (47%), Gaps = 16/140 (11%)

Query: 62  VLENLDSVLSENQEHEVELELLREDNEQLLTQYERE-KALRRQAE------EKFIEFEDA 114
           + E +   L   ++ + E+E  +E  +  +   ERE +A ++QAE      ++ +   D 
Sbjct: 329 IREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDI 388

Query: 115 LEQE--------KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
           L +         +K+  + V+ +E   R LE + +NY D+  +  +    ++KE +    
Sbjct: 389 LNKNMLKAVNATQKQTDL-VKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYIN 447

Query: 167 RHTEMIQTYVEHIERSKMQQ 186
           + +++ Q  + ++E  K+++
Sbjct: 448 QASDLTQKVLMNMEDIKVRE 467


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 47/176 (26%), Positives = 89/176 (50%), Gaps = 15/176 (8%)

Query: 25  MSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLR 84
           +S++V  L   I +E + L +C  + + K+LM      LE     L EN E ++++  L 
Sbjct: 503 LSKKVEILENEIVQEKQSLQNC--QNLSKDLMKEKAQ-LEKTIETLRENSERQIKI--LE 557

Query: 85  EDNEQL---LTQYEREKALRRQAEEKFIEFEDALEQEK-KELQIQVEHYEFQTRQLELKA 140
           ++NE L   ++   +   +  +A  K IE E+ +  E  KE   ++   EF+ RQ++ + 
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617

Query: 141 KNYADQISRLEERESEMK--KEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE 194
           ++Y ++  R EE E+E+   ++ N L Q+    ++   E IE  + +    NS+ E
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE----NSELE 669



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 98/519 (18%), Positives = 214/519 (41%), Gaps = 30/519 (5%)

Query: 63   LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
            LE L +   + +  EV  + L  +N++L    E      +Q E    E +D LE E + L
Sbjct: 741  LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES---ELQD-LEMENQTL 796

Query: 123  QIQVEHYEFQTR---QLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
            Q  +E  +  ++   QLE + K+   + S+LE+ + +++KE   L Q+  E+  T +E  
Sbjct: 797  QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKDTTLEE- 854

Query: 180  ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTV--RAQIGGK-LVPAGDHWHLS 236
               K+  +   ++T S   G  KE    L      +  +  RA I  K LV   +     
Sbjct: 855  NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914

Query: 237  DLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLG 296
             L   Q ++  +    E+ + G +          T  ++    + S   + L +SL+   
Sbjct: 915  KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST-DDSRYKLLESKLESTLKKSLEIKE 973

Query: 297  DYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPE 356
            +     K +       +S N   Q+ QE++ V     +  +  D + ++ S+P +    +
Sbjct: 974  E-----KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS-GED 1027

Query: 357  TRLDRTGSSPTQGIVNKAFGI-----NTDSLYHELSTAGSEVIGDVDEGADLLGE-FSVR 410
             + +R     T+ ++     +     N  +L  E     +++     +  +L  +  +++
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087

Query: 411  DDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKV 470
                 + ++   L  +N++L    + LN     L+ +  QL  +Q  L  E E+  + + 
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147

Query: 471  KLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMAR 530
             L++    L ++ ++++   ++  R+  E    +S +   +S    +    R       +
Sbjct: 1148 DLKSLYDSLIKDHEKLE---LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1204

Query: 531  VLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKK 569
            +L ++ Q ++  +E    V   +M+  ++ H +V  + K
Sbjct: 1205 LLKQKGQLED--LEKMLKVEQEKMLLENKNHETVAAEYK 1241



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 98/529 (18%), Positives = 206/529 (38%), Gaps = 51/529 (9%)

Query: 48   DEEVVKEL---MPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQA 104
            ++E+VK     +  +V + E+L S   + Q+   +LE L  + E++    ER     +  
Sbjct: 890  NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949

Query: 105  EE-KFIEFEDALEQE-KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYN 162
            ++ ++   E  LE   KK L+I+ E       +LE ++ NY  Q   L +    +KK Y 
Sbjct: 950  DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQ---LRQELKTVKKNYE 1005

Query: 163  ALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQI 222
            AL QR  E      E + +S     G +++ E      R+ + T+  +  + D  +  + 
Sbjct: 1006 ALKQRQDE------ERMVQSSPPISGEDNKWE------RESQETTRELLKVKDRLIEVER 1053

Query: 223  GGKLVPAGDHWHLSDLGQLQSSSS---YQCPQDEMSESGQSSAAATPSTTGTKSNTPTSS 279
                + A      + L QL++ ++    Q    +           T  T   K     S+
Sbjct: 1054 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113

Query: 280  VPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWS 339
            + S + + +N++ Q L                        Q + E  N S+     D  S
Sbjct: 1114 LNSQSTSLMNQNAQLLIQ----------------------QSSLENENESVIKEREDLKS 1151

Query: 340  DVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDE 399
                +I    +L++  E +     S  ++    K+   N +  + +L    ++++    +
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211

Query: 400  GADLLGEFSVRDDFFGM-GKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVL 458
              DL     V  +   +  K    +  E  +L    + LN   + L+ + + L  + + L
Sbjct: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1271

Query: 459  RGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMA 518
            +  L  +K  + +LE    +L+E+ +++     I   +   + E +S       ++    
Sbjct: 1272 KSLLNNSKLEQTRLEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLKGNLEEENRHL 1327

Query: 519  QRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEK 567
              +  T +   R L+E+N   + L  +++     ++    R+   ++EK
Sbjct: 1328 LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 47/176 (26%), Positives = 80/176 (45%), Gaps = 24/176 (13%)

Query: 53  KELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQL------LTQYEREKALRRQAEE 106
           + L   + N  + +  + SE Q+ E+E + L+++ E+L      L Q E+E     Q   
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825

Query: 107 KFIEFEDALEQEKKELQIQ-------VEHYEFQTRQLELKAKNYADQISRLEE---RESE 156
           +  + +  LE+E K L+ Q       +E    +   LE + K  + +I   +E   R  E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885

Query: 157 MKKEYNALHQRHTEMIQTYV---EHI--ERSKMQQVGGNSQT---ESSLPGRRKER 204
           ++KE   L +R T  I+T V   E +  E+ K QQ+  + +    E    G  KER
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 111/604 (18%), Positives = 235/604 (38%), Gaps = 108/604 (17%)

Query: 53  KELMPLVVNVLENLDSVLSENQEHEVELELLREDNE------------------------ 88
           +++ PL+ N+  +L  ++ E  EH   +  L E+ +                        
Sbjct: 184 EDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243

Query: 89  --------QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL---E 137
                   +L     + + LR++ EEK  +  D  +QE ++++I+++  + +   L    
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC-KQELEQMEIELKRLQQENMNLLSDA 302

Query: 138 LKAKNYADQISRLEER-------ESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGN 190
             A+ Y D++  L E+       ESE+ +    LH    E  +  VE ++      +   
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETK 360

Query: 191 SQTESSLPGRRKERPTSLNVFPLADGTVRAQIGG----------KLVPAGDHWHLSDLGQ 240
           +  E  L G R  R   L+     +  ++A++            K+    +     ++ Q
Sbjct: 361 TMLEDQLEGTR-ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419

Query: 241 LQSSSSYQCPQDEMSESGQSS--AAATPSTTGTKSNTPTSS------VPSAAVTPLNESL 292
            QS         E+ +  ++S  + A   + G + N  TSS      + + ++T   E L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479

Query: 293 QPLGDYGVGSKNSKRAREKRDSR------NMEVQVTQEMRNVSIGMGSSDEWSDVQDIID 346
           +   D   G+ +     EK + R       +E ++ QE +++      S      +D++ 
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS------KDLMK 533

Query: 347 STPELDMCPETRLDRTGSSPTQGIV---NKAFGINTDSLYHELSTAGSEVIGDVDEGADL 403
              +L+   ET   R  S     I+   N+       SL      +    + D+++   +
Sbjct: 534 EKAQLEKTIETL--RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591

Query: 404 LGEFSVRDDFFGMGK---EVGNLLLENSQLLETKNALNVVKNDL--IAKVDQLSGEQ--- 455
           L E S+++    + K   E   +  E     E       ++N+L  + K ++L  ++   
Sbjct: 592 LHE-SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 456 -EVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAE----------DV 504
            ++   ++EA +Q   +LE   ++L++ L   K+         KE ++          +V
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710

Query: 505 SSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSV 564
            S  C     + MAQ     ++E   +  E+ Q K+ L  L+ + + TE +  S +   +
Sbjct: 711 ESLKCA---SMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763

Query: 565 QEKK 568
           + ++
Sbjct: 764 ENQR 767



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 3/125 (2%)

Query: 63  LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
           +E+L     +  + ++E + L  + EQL    E  KA  ++ E   + ++  L+ E + L
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ-GLDIENQRL 768

Query: 123 QIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ--RHTEMIQTYVEHIE 180
           Q  +E+   + +QLE + ++   +   L++   E+K     L Q  +  + ++     +E
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828

Query: 181 RSKMQ 185
           + K Q
Sbjct: 829 KDKKQ 833


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 47/176 (26%), Positives = 89/176 (50%), Gaps = 15/176 (8%)

Query: 25  MSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLR 84
           +S++V  L   I +E + L +C  + + K+LM      LE     L EN E ++++  L 
Sbjct: 503 LSKKVEILENEIVQEKQSLQNC--QNLSKDLMKEKAQ-LEKTIETLRENSERQIKI--LE 557

Query: 85  EDNEQL---LTQYEREKALRRQAEEKFIEFEDALEQEK-KELQIQVEHYEFQTRQLELKA 140
           ++NE L   ++   +   +  +A  K IE E+ +  E  KE   ++   EF+ RQ++ + 
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617

Query: 141 KNYADQISRLEERESEMK--KEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE 194
           ++Y ++  R EE E+E+   ++ N L Q+    ++   E IE  + +    NS+ E
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE----NSELE 669



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 98/528 (18%), Positives = 206/528 (39%), Gaps = 50/528 (9%)

Query: 48   DEEVVKEL---MPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQA 104
            ++E+VK     +  +V + E+L S   + Q+   +LE L  + E++    ER     +  
Sbjct: 890  NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949

Query: 105  EEKFIEFEDALEQE-KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNA 163
            ++++   E  LE   KK L+I+ E       +LE ++ NY  Q   L +    +KK Y A
Sbjct: 950  DDRYKLLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQ---LRQELKTVKKNYEA 1005

Query: 164  LHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIG 223
            L QR  E      E + +S     G +++ E      R+ + T+  +  + D  +  +  
Sbjct: 1006 LKQRQDE------ERMVQSSPPISGEDNKWE------RESQETTRELLKVKDRLIEVERN 1053

Query: 224  GKLVPAGDHWHLSDLGQLQSSSS---YQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSV 280
               + A      + L QL++ ++    Q    +           T  T   K     S++
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1113

Query: 281  PSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSD 340
             S + + +N++ Q L                        Q + E  N S+     D  S 
Sbjct: 1114 NSQSTSLMNQNAQLLIQ----------------------QSSLENENESVIKEREDLKSL 1151

Query: 341  VQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEG 400
               +I    +L++  E +     S  ++    K+   N +  + +L    ++++    + 
Sbjct: 1152 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1211

Query: 401  ADLLGEFSVRDDFFGM-GKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLR 459
             DL     V  +   +  K    +  E  +L    + LN   + L+ + + L  + + L+
Sbjct: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1271

Query: 460  GELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQ 519
              L  +K  + +LE    +L+E+ +++     I   +   + E +S       ++     
Sbjct: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLKGNLEEENRHLL 1327

Query: 520  RRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEK 567
             +  T +   R L+E+N   + L  +++     ++    R+   ++EK
Sbjct: 1328 DQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 98/519 (18%), Positives = 212/519 (40%), Gaps = 31/519 (5%)

Query: 63   LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
            LE L +   + +  EV  + L  +N++L    E      +Q E    E +D LE E + L
Sbjct: 741  LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES---ELQD-LEMENQTL 796

Query: 123  QIQVEHYEFQTR---QLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
            Q  +E  +  ++   QLE + K+   + S+LE+ + +++KE   L Q+  E+  T +E  
Sbjct: 797  QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKDTTLEE- 854

Query: 180  ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTV--RAQIGGK-LVPAGDHWHLS 236
               K+  +   ++T S   G  KE    L      +  +  RA I  K LV   +     
Sbjct: 855  NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914

Query: 237  DLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLG 296
             L   Q ++  +    E+ + G +          T        + S   + L +SL+   
Sbjct: 915  KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDR--YKLLESKLESTLKKSLEIKE 972

Query: 297  DYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPE 356
            +     K +       +S N   Q+ QE++ V     +  +  D + ++ S+P +    +
Sbjct: 973  E-----KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS-GED 1026

Query: 357  TRLDRTGSSPTQGIVNKAFGI-----NTDSLYHELSTAGSEVIGDVDEGADLLGE-FSVR 410
             + +R     T+ ++     +     N  +L  E     +++     +  +L  +  +++
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086

Query: 411  DDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKV 470
                 + ++   L  +N++L    + LN     L+ +  QL  +Q  L  E E+  + + 
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1146

Query: 471  KLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMAR 530
             L++    L ++ ++++   ++  R+  E    +S +   +S    +    R       +
Sbjct: 1147 DLKSLYDSLIKDHEKLE---LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203

Query: 531  VLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKK 569
            +L ++ Q ++  +E    V   +M+  ++ H +V  + K
Sbjct: 1204 LLKQKGQLED--LEKMLKVEQEKMLLENKNHETVAAEYK 1240



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 47/176 (26%), Positives = 80/176 (45%), Gaps = 24/176 (13%)

Query: 53  KELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQL------LTQYEREKALRRQAEE 106
           + L   + N  + +  + SE Q+ E+E + L+++ E+L      L Q E+E     Q   
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825

Query: 107 KFIEFEDALEQEKKELQIQ-------VEHYEFQTRQLELKAKNYADQISRLEE---RESE 156
           +  + +  LE+E K L+ Q       +E    +   LE + K  + +I   +E   R  E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885

Query: 157 MKKEYNALHQRHTEMIQTYV---EHI--ERSKMQQVGGNSQT---ESSLPGRRKER 204
           ++KE   L +R T  I+T V   E +  E+ K QQ+  + +    E    G  KER
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 111/604 (18%), Positives = 235/604 (38%), Gaps = 108/604 (17%)

Query: 53  KELMPLVVNVLENLDSVLSENQEHEVELELLREDNE------------------------ 88
           +++ PL+ N+  +L  ++ E  EH   +  L E+ +                        
Sbjct: 184 EDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243

Query: 89  --------QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL---E 137
                   +L     + + LR++ EEK  +  D  +QE ++++I+++  + +   L    
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC-KQELEQMEIELKRLQQENMNLLSDA 302

Query: 138 LKAKNYADQISRLEER-------ESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGN 190
             A+ Y D++  L E+       ESE+ +    LH    E  +  VE ++      +   
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETK 360

Query: 191 SQTESSLPGRRKERPTSLNVFPLADGTVRAQIGG----------KLVPAGDHWHLSDLGQ 240
           +  E  L G R  R   L+     +  ++A++            K+    +     ++ Q
Sbjct: 361 TMLEDQLEGTR-ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419

Query: 241 LQSSSSYQCPQDEMSESGQSS--AAATPSTTGTKSNTPTSS------VPSAAVTPLNESL 292
            QS         E+ +  ++S  + A   + G + N  TSS      + + ++T   E L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479

Query: 293 QPLGDYGVGSKNSKRAREKRDSR------NMEVQVTQEMRNVSIGMGSSDEWSDVQDIID 346
           +   D   G+ +     EK + R       +E ++ QE +++      S      +D++ 
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS------KDLMK 533

Query: 347 STPELDMCPETRLDRTGSSPTQGIV---NKAFGINTDSLYHELSTAGSEVIGDVDEGADL 403
              +L+   ET   R  S     I+   N+       SL      +    + D+++   +
Sbjct: 534 EKAQLEKTIETL--RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591

Query: 404 LGEFSVRDDFFGMGK---EVGNLLLENSQLLETKNALNVVKNDL--IAKVDQLSGEQ--- 455
           L E S+++    + K   E   +  E     E       ++N+L  + K ++L  ++   
Sbjct: 592 LHE-SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 456 -EVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAE----------DV 504
            ++   ++EA +Q   +LE   ++L++ L   K+         KE ++          +V
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710

Query: 505 SSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSV 564
            S  C     + MAQ     ++E   +  E+ Q K+ L  L+ + + TE +  S +   +
Sbjct: 711 ESLKCA---SMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763

Query: 565 QEKK 568
           + ++
Sbjct: 764 ENQR 767



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 3/125 (2%)

Query: 63  LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
           +E+L     +  + ++E + L  + EQL    E  KA  ++ E   + ++  L+ E + L
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ-GLDIENQRL 768

Query: 123 QIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ--RHTEMIQTYVEHIE 180
           Q  +E+   + +QLE + ++   +   L++   E+K     L Q  +  + ++     +E
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828

Query: 181 RSKMQ 185
           + K Q
Sbjct: 829 KDKKQ 833


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 50/179 (27%), Positives = 88/179 (49%), Gaps = 20/179 (11%)

Query: 49  EEVVKELMPLVVNVLENLDSVLSENQEHEVEL---ELLREDNEQLLT---QYEREKALRR 102
           E  +K +   V  VLE     L E+++ +++    +L +E+ E++L    Q E+  +  R
Sbjct: 589 EAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLR 648

Query: 103 QAEEKFIEFEDALEQEKKE-----LQIQVEHYEFQTRQLELKAKNYADQISRLEERESEM 157
           +  +K IE E+A  +E++      L+ QV+    Q  + +++A+  A      EE ES+ 
Sbjct: 649 ERLQKAIEEEEARMREEESQRLSWLRAQVQS-STQADEDQIRAEQEASLQKLREELESQQ 707

Query: 158 KKEYNALHQRHTEMIQTYVEHIERS-KMQQVGGNS-------QTESSLPGRRKERPTSL 208
           K E  +L Q++ +M++   E IE S K +Q   N+       Q    L G RKE   +L
Sbjct: 708 KAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATL 766



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 52/259 (20%), Positives = 90/259 (34%), Gaps = 61/259 (23%)

Query: 63   LENLDSVLSENQEHEVELELLREDNEQLLTQYER---------EKALRRQAEEKFIEFED 113
            +E+L   L  NQ  EV   L +   +  L              E    R A+E  ++   
Sbjct: 1063 IEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTR 1122

Query: 114  ALEQEKKELQIQVEHYEFQT-------------RQLELKAKNYADQISRLEERESEMKKE 160
            ++ + +  L+   +H+  +              + LE   KN   +   L+E +S M+K 
Sbjct: 1123 SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKG 1182

Query: 161  YNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRA 220
            +N L ++  ++                   +Q ESSL     +  T              
Sbjct: 1183 HNLLKKKEEKL-------------------NQLESSLWEEASDEGT-------------- 1209

Query: 221  QIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSV 280
             +GG        + LSD+  L S SS            Q    +TPS T  K +  + S+
Sbjct: 1210 -LGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRKIHGLSHSL 1268

Query: 281  PS-----AAVTPLNESLQP 294
                   ++V  + +SL P
Sbjct: 1269 RQISSQLSSVLSILDSLNP 1287



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 35/141 (24%), Positives = 63/141 (44%), Gaps = 13/141 (9%)

Query: 63  LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
           LE  +  + E  + E+E     E +EQ      +EKAL++  E+   E ++A+   +KE 
Sbjct: 714 LEQKNRQMLEQLKEEIEAS---EKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEH 770

Query: 123 QIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERS 182
             ++E        LE K   + + +S L+++  E +++  A  Q+        VEH    
Sbjct: 771 SAELERL---CSSLEAK---HREVVSSLQKKIQEAQQKEEAQLQK----CLGQVEHRVHQ 820

Query: 183 KMQQVGGNSQTESSLPGRRKE 203
           K   V G     SSL   +++
Sbjct: 821 KSYHVAGYEHELSSLLREKRQ 841


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 102/539 (18%), Positives = 216/539 (40%), Gaps = 52/539 (9%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            E  ++E   ++  + + L    +  QE E E + ++E+ E L  Q E  KA     E++ 
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 1994

Query: 109  IEFEDALEQEKKELQIQVE----HYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
            ++  + L +EK E+Q Q E      + Q + LE+  +   +Q+SR  E E E   E   L
Sbjct: 1995 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE---EQVSRFIELEQEKNTELMDL 2051

Query: 165  HQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVF----PLADGTVR- 219
             Q++ + ++  +E + +   +Q               ++    L V     P+++   R 
Sbjct: 2052 RQQN-QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110

Query: 220  -AQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMS-------ESGQSSAAATPSTTGT 271
              Q+   L    D      L + Q     Q   +E+        E  Q+   +  +    
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170

Query: 272  KSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQ---EMRNV 328
            +      +V +     L   LQ        ++     R++++  N+E Q+ Q   E+ N 
Sbjct: 2171 EDRKHFGAVEAKPELSLEVQLQ--------AERDAIDRKEKEITNLEEQLEQFREELENK 2222

Query: 329  SIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELST 388
            +  +       ++Q    +T   ++  E +L +         + ++  ++T    H L  
Sbjct: 2223 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD-QHVLFG 2281

Query: 389  AGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKV 448
              +++I + +   D L E   +        +    +  +++++E KN L     DL  ++
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTK-------LQQQLKITTDNKVIEEKNEL---IRDLETQI 2331

Query: 449  DQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL 508
            + L  +QE ++   E   +   +L   I++L++EL  +  +  +      EEA+ +   L
Sbjct: 2332 ECLMSDQECVKRNREEEIE---QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQL 2388

Query: 509  -CTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQE 566
                ++K+ + Q+      EM      +N  KE   ++ +  +  E+    RE  SV++
Sbjct: 2389 DVVIAEKLALEQQVETANEEMT---FMKNVLKETNFKMNQLTQ--ELFSLKRERESVEK 2442



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 37/152 (24%), Positives = 72/152 (47%), Gaps = 22/152 (14%)

Query: 27  ERVSGLAGSIYREFERLIHCYDEEVVKE-LMPLVVNVLENLDSVLSENQEHEVELELLRE 85
           +++ GL   + ++ E +    D  + K+  + L ++ L++L   L  ++  E+ L++   
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724

Query: 86  DNE-QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYA 144
             E ++L Q E+EK                LEQE +ELQ++ E  E   +Q++ K  +  
Sbjct: 725 QKEIEILRQEEKEKG--------------TLEQEVQELQLKTELLE---KQMKEKENDLQ 767

Query: 145 DQISRLEERESEMKKEYNALHQR---HTEMIQ 173
           ++ ++LE   S +K E   L      HT + Q
Sbjct: 768 EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ 799



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 29/130 (22%), Positives = 62/130 (47%), Gaps = 18/130 (13%)

Query: 437 LNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARRE 496
           +NV  N+L  K+   + ++E L+ EL    + K  L+ ++++L EEL   + +   AR+ 
Sbjct: 491 MNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT 550

Query: 497 PKEE-------------AEDVSSYLCTESD---KIPMAQRRRFT--RVEMARVLMERNQY 538
             E+              ED+ + + + S+   ++ +      T  ++++  +  E+N  
Sbjct: 551 IAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV 610

Query: 539 KERLMELQEA 548
            +R+ E QEA
Sbjct: 611 LDRMAESQEA 620



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 105/510 (20%), Positives = 200/510 (39%), Gaps = 73/510 (14%)

Query: 64   ENLDSVLSENQEHEV-----ELELLREDNEQLLT----QYEREKALRRQAEEKFIEFEDA 114
            EN    +SEN++ E+     E++  +E+   LL     +Y +   L+ +  + + +  D 
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287

Query: 115  LEQEKKELQIQVEHYEF-----QTRQLELKAKNYADQIS--------RLEERESEMKKEY 161
            ++ E  E  +  E  EF     Q   LE    N+  ++S        +LEE+  E++   
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLI 1347

Query: 162  NALHQRHTEMIQTYVEHIE-RSKMQQVGGNSQTESSLPGRR---KERPTSLNVFPLADGT 217
            ++L Q+  E  Q Y   I    K  Q    S    SLP       E      ++P     
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYP--GSC 1405

Query: 218  VRAQIGGKLVPAGDHW--HLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTT------ 269
            V+  I G +  +G+      +++ +L      +  ++E+++   S + A    T      
Sbjct: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465

Query: 270  GTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVS 329
            G K NT +S    A         Q    Y    K S+     +    ++V+  +E + +S
Sbjct: 1466 GGKENTASSKQAHAV-------CQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLS 1518

Query: 330  IGMGSSDEW-----SDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
              +G   +      SD  DI    PE   C  T  +   S     IV +       S++ 
Sbjct: 1519 KELGEHGKEILLSNSDPHDI----PESKDCVLTISEEMFSKDKTFIVRQ-------SIHD 1567

Query: 385  ELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDL 444
            E+S +  +    +     +L E  + D    M +E+     E+ Q  E     ++ + + 
Sbjct: 1568 EISVSSMDASRQL-----MLNEEQLED----MRQELVRQYQEHQQATELLRQAHMRQMER 1618

Query: 445  IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE----EELKRVKSEAIIARREPKEE 500
              + DQ   ++E+ R   + A+++ +  EN + E E    EEL+ +K  ++  R +   E
Sbjct: 1619 -QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677

Query: 501  AEDVSSYLCTESDKIPMAQRRRFTRVEMAR 530
              + S+     ++     + + F   E+ R
Sbjct: 1678 LRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 105/519 (20%), Positives = 195/519 (37%), Gaps = 91/519 (17%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            E++ +EL+    N + +L   LS+ ++H  E +       + L+  E+E     Q  +K 
Sbjct: 2713 EKLQEELLVKETN-MTSLQKDLSQVRDHLAEAK-------EKLSILEKEDETEVQESKKA 2764

Query: 109  IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRH 168
              FE    +  K +  Q +        L++ + N   QI  ++    ++  +     +  
Sbjct: 2765 CMFEPLPIKLSKSIASQTDG------TLKISSSNQTPQIL-VKNAGIQINLQSECSSEEV 2817

Query: 169  TEMIQTYVEHIERSKMQQVGG------NSQTESSLPGRRKERPTSLNVFPLADGTVRAQI 222
            TE+I  + E IE  KMQ++         S+  S     ++E   ++ +     GT++A I
Sbjct: 2818 TEIISQFTEKIE--KMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2875

Query: 223  GGKLVPAGDHWHLSDLGQLQSSSSYQ----CPQDEMSESGQSSAAA-------TPSTTGT 271
                   G     S + +L  S +YQ    C  D  S+ GQ                 G 
Sbjct: 2876 QCLRSKEG-----SSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGE 2930

Query: 272  KSNTPTSSVPSAAVTPL----NESLQPLG----------DYGVGSKNSKRAREKRDSRN- 316
            +S + T S P      L    NE +Q L           D+ +   +     E++   N 
Sbjct: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990

Query: 317  ----------MEVQVTQEMRNVSIGMGSSDEWSDV------QDIIDSTPELDMCPETRLD 360
                      M++Q   E+ + S    S  +W         Q  ++    L     T L 
Sbjct: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3050

Query: 361  RTGSSPTQGIVN------KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFF 414
              G++   G++N      +  G+   +    L  A    +  + E   L  + + R    
Sbjct: 3051 ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL--LSEIQALHAQMNGRKITL 3108

Query: 415  GMGKEVG---------NLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAA 465
               +E           N+  + SQ+LE +  L+ +K+      +QLS E+ V+       
Sbjct: 3109 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3168

Query: 466  KQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDV 504
             Q K++LE  +K   + LK +++     R E K++ ++V
Sbjct: 3169 AQTKLELETTLKAQHKHLKELEA----FRLEVKDKTDEV 3203



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 33/146 (22%), Positives = 66/146 (45%), Gaps = 29/146 (19%)

Query: 67   DSVLSENQEHEVELELLREDNE----QLLTQYEREKALRRQ---------------AEEK 107
            D+ LSE Q   +EL++L E  +    ++ +  +RE+ L  Q               +E+ 
Sbjct: 3285 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3344

Query: 108  FIEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
              E +  LE++     EL  + E Y+  +    L+ +   ++  ++  +  + ++E N  
Sbjct: 3345 LKELQKQLEEKHSRIVELLNETEKYKLDS----LQTRQQMEKDRQVHRKTLQTEQEANTE 3400

Query: 165  HQRHTEMIQTYVEHIER---SKMQQV 187
             Q+    +Q+ VE ++R    K QQV
Sbjct: 3401 GQKKMHELQSKVEDLQRQLEEKRQQV 3426


>gi|93204881 Rab interacting lysosomal protein [Homo sapiens]
          Length = 401

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 47/157 (29%), Positives = 69/157 (43%), Gaps = 23/157 (14%)

Query: 26  SERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENL---------DSVLSENQEH 76
           +E V  LAG++  E + L   +  E    L+PLVV  LE L         DS+    Q  
Sbjct: 25  AELVYHLAGALGTELQDLARRFGPEAAAGLVPLVVRALELLEQAAVGPAPDSLQVSAQPA 84

Query: 77  EVELELLREDNEQLLTQY----EREKALRRQAEEKFIEFEDALE----------QEKKEL 122
           E EL  LRE+NE+L  +     + E+AL RQ +E      D L           QE + L
Sbjct: 85  EQELRRLREENERLRRELRAGPQEERALLRQLKEVTDRQRDELRAHNRDLRQRGQETEAL 144

Query: 123 QIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKK 159
           Q Q++       +L  K      Q+   ++RE E ++
Sbjct: 145 QEQLQRLLLVNAELRHKLAAMQTQLRAAQDRERERQQ 181


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 101/532 (18%), Positives = 213/532 (40%), Gaps = 46/532 (8%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            E  ++E   ++  + + L    +  QE E E + ++E+ E L  Q E  KA     E++ 
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 1994

Query: 109  IEFEDALEQEKKELQIQVE----HYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
            ++  + L +EK E+Q Q E      + Q + LE+  +   +Q+SR  E E E   E   L
Sbjct: 1995 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE---EQVSRFIELEQEKNTELMDL 2051

Query: 165  HQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVF----PLADGTVR- 219
             Q++ + ++  +E + +   +Q               ++    L V     P+++   R 
Sbjct: 2052 RQQN-QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110

Query: 220  -AQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTS 278
              Q+   L    D      L + Q     Q  ++E  E  +            +      
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQ-ERNEEIEKLEFRVRELEQALLVEDRKHFG 2169

Query: 279  SVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQ---EMRNVSIGMGSS 335
            +V +     L   LQ        ++     R++++  N+E Q+ Q   E+ N +  +   
Sbjct: 2170 AVEAKPELSLEVQLQ--------AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2221

Query: 336  DEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIG 395
                ++Q    +T   ++  E +L +         + ++  ++T    H L    +++I 
Sbjct: 2222 HMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD-QHVLFGKFAQIIQ 2280

Query: 396  DVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQ 455
            + +   D L E   +        +    +  +++++E KN L     DL  +++ L  +Q
Sbjct: 2281 EKEVEIDQLNEQVTK-------LQQQLKITTDNKVIEEKNEL---IRDLETQIECLMSDQ 2330

Query: 456  EVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL-CTESDK 514
            E ++   E   +   +L   I++L++EL  +  +  +      EEA+ +   L    ++K
Sbjct: 2331 ECVKRNREEEIE---QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK 2387

Query: 515  IPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQE 566
            + + Q+      EM      +N  KE   ++ +  +  E+    RE  SV++
Sbjct: 2388 LALEQQVETANEEMT---FMKNVLKETNFKMNQLTQ--ELFSLKRERESVEK 2434



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 37/152 (24%), Positives = 72/152 (47%), Gaps = 22/152 (14%)

Query: 27  ERVSGLAGSIYREFERLIHCYDEEVVKE-LMPLVVNVLENLDSVLSENQEHEVELELLRE 85
           +++ GL   + ++ E +    D  + K+  + L ++ L++L   L  ++  E+ L++   
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724

Query: 86  DNE-QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYA 144
             E ++L Q E+EK                LEQE +ELQ++ E  E   +Q++ K  +  
Sbjct: 725 QKEIEILRQEEKEKG--------------TLEQEVQELQLKTELLE---KQMKEKENDLQ 767

Query: 145 DQISRLEERESEMKKEYNALHQR---HTEMIQ 173
           ++ ++LE   S +K E   L      HT + Q
Sbjct: 768 EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ 799



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 29/130 (22%), Positives = 62/130 (47%), Gaps = 18/130 (13%)

Query: 437 LNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARRE 496
           +NV  N+L  K+   + ++E L+ EL    + K  L+ ++++L EEL   + +   AR+ 
Sbjct: 491 MNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT 550

Query: 497 PKEE-------------AEDVSSYLCTESD---KIPMAQRRRFT--RVEMARVLMERNQY 538
             E+              ED+ + + + S+   ++ +      T  ++++  +  E+N  
Sbjct: 551 IAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV 610

Query: 539 KERLMELQEA 548
            +R+ E QEA
Sbjct: 611 LDRMAESQEA 620



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 105/510 (20%), Positives = 200/510 (39%), Gaps = 73/510 (14%)

Query: 64   ENLDSVLSENQEHEV-----ELELLREDNEQLLT----QYEREKALRRQAEEKFIEFEDA 114
            EN    +SEN++ E+     E++  +E+   LL     +Y +   L+ +  + + +  D 
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287

Query: 115  LEQEKKELQIQVEHYEF-----QTRQLELKAKNYADQIS--------RLEERESEMKKEY 161
            ++ E  E  +  E  EF     Q   LE    N+  ++S        +LEE+  E++   
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLI 1347

Query: 162  NALHQRHTEMIQTYVEHIE-RSKMQQVGGNSQTESSLPGRR---KERPTSLNVFPLADGT 217
            ++L Q+  E  Q Y   I    K  Q    S    SLP       E      ++P     
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYP--GSC 1405

Query: 218  VRAQIGGKLVPAGDHW--HLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTT------ 269
            V+  I G +  +G+      +++ +L      +  ++E+++   S + A    T      
Sbjct: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465

Query: 270  GTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVS 329
            G K NT +S    A         Q    Y    K S+     +    ++V+  +E + +S
Sbjct: 1466 GGKENTASSKQAHAV-------CQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLS 1518

Query: 330  IGMGSSDEW-----SDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
              +G   +      SD  DI    PE   C  T  +   S     IV +       S++ 
Sbjct: 1519 KELGEHGKEILLSNSDPHDI----PESKDCVLTISEEMFSKDKTFIVRQ-------SIHD 1567

Query: 385  ELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDL 444
            E+S +  +    +     +L E  + D    M +E+     E+ Q  E     ++ + + 
Sbjct: 1568 EISVSSMDASRQL-----MLNEEQLED----MRQELVRQYQEHQQATELLRQAHMRQMER 1618

Query: 445  IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE----EELKRVKSEAIIARREPKEE 500
              + DQ   ++E+ R   + A+++ +  EN + E E    EEL+ +K  ++  R +   E
Sbjct: 1619 -QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677

Query: 501  AEDVSSYLCTESDKIPMAQRRRFTRVEMAR 530
              + S+     ++     + + F   E+ R
Sbjct: 1678 LRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 105/519 (20%), Positives = 195/519 (37%), Gaps = 91/519 (17%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            E++ +EL+    N + +L   LS+ ++H  E +       + L+  E+E     Q  +K 
Sbjct: 2705 EKLQEELLVKETN-MTSLQKDLSQVRDHLAEAK-------EKLSILEKEDETEVQESKKA 2756

Query: 109  IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRH 168
              FE    +  K +  Q +        L++ + N   QI  ++    ++  +     +  
Sbjct: 2757 CMFEPLPIKLSKSIASQTDG------TLKISSSNQTPQIL-VKNAGIQINLQSECSSEEV 2809

Query: 169  TEMIQTYVEHIERSKMQQVGG------NSQTESSLPGRRKERPTSLNVFPLADGTVRAQI 222
            TE+I  + E IE  KMQ++         S+  S     ++E   ++ +     GT++A I
Sbjct: 2810 TEIISQFTEKIE--KMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2867

Query: 223  GGKLVPAGDHWHLSDLGQLQSSSSYQ----CPQDEMSESGQSSAAA-------TPSTTGT 271
                   G     S + +L  S +YQ    C  D  S+ GQ                 G 
Sbjct: 2868 QCLRSKEG-----SSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGE 2922

Query: 272  KSNTPTSSVPSAAVTPL----NESLQPLG----------DYGVGSKNSKRAREKRDSRN- 316
            +S + T S P      L    NE +Q L           D+ +   +     E++   N 
Sbjct: 2923 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2982

Query: 317  ----------MEVQVTQEMRNVSIGMGSSDEWSDV------QDIIDSTPELDMCPETRLD 360
                      M++Q   E+ + S    S  +W         Q  ++    L     T L 
Sbjct: 2983 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3042

Query: 361  RTGSSPTQGIVN------KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFF 414
              G++   G++N      +  G+   +    L  A    +  + E   L  + + R    
Sbjct: 3043 ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL--LSEIQALHAQMNGRKITL 3100

Query: 415  GMGKEVG---------NLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAA 465
               +E           N+  + SQ+LE +  L+ +K+      +QLS E+ V+       
Sbjct: 3101 KREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3160

Query: 466  KQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDV 504
             Q K++LE  +K   + LK +++     R E K++ ++V
Sbjct: 3161 AQTKLELETTLKAQHKHLKELEA----FRLEVKDKTDEV 3195



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 12/133 (9%)

Query: 38   REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYERE 97
            +E   L+    E +  E  P+   +L+  + ++ E  E + + E +R+D ++ +      
Sbjct: 1970 QEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQV------ 2023

Query: 98   KALRRQAEE---KFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERE 154
            KAL    EE   +FIE E     E  +L+ Q +  E   +QLE   K   +Q    E   
Sbjct: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALE---KQLEKMRKFLDEQAIDREHER 2080

Query: 155  SEMKKEYNALHQR 167
               ++E   L Q+
Sbjct: 2081 DVFQQEIQKLEQQ 2093



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 33/146 (22%), Positives = 66/146 (45%), Gaps = 29/146 (19%)

Query: 67   DSVLSENQEHEVELELLREDNE----QLLTQYEREKALRRQ---------------AEEK 107
            D+ LSE Q   +EL++L E  +    ++ +  +RE+ L  Q               +E+ 
Sbjct: 3277 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3336

Query: 108  FIEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
              E +  LE++     EL  + E Y+  +    L+ +   ++  ++  +  + ++E N  
Sbjct: 3337 LKELQKQLEEKHSRIVELLNETEKYKLDS----LQTRQQMEKDRQVHRKTLQTEQEANTE 3392

Query: 165  HQRHTEMIQTYVEHIER---SKMQQV 187
             Q+    +Q+ VE ++R    K QQV
Sbjct: 3393 GQKKMHELQSKVEDLQRQLEEKRQQV 3418


>gi|195947382 Rab interacting lysosomal protein-like 1 [Homo
           sapiens]
          Length = 403

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 61/228 (26%), Positives = 105/228 (46%), Gaps = 39/228 (17%)

Query: 29  VSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLS------ENQEHEVELEL 82
           V  +A  +  EFER+I  +  E +  LMP VV VLE L+ ++S      E  E  +EL+ 
Sbjct: 27  VYDIASLVGHEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDR 86

Query: 83  LR-EDNEQLLTQYEREKAL-------RRQAEEKFIEFEDALEQEKKELQIQVEH------ 128
           LR E  +++  + + +K L       R +A++   +    L++E K+L   + H      
Sbjct: 87  LRLERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQ-LQEENKQLMTNLSHKDVNFS 145

Query: 129 -YEFQ--------TRQLELKAKNYADQIS---RLEERESEMKKE-YNALHQRHTEMIQTY 175
             EFQ         RQ+  K K   D+     R ++RE  +K E   AL Q+ T +++  
Sbjct: 146 EEEFQKHEGMSERERQVMKKLKEVVDKQRDEIRAKDRELGLKNEDVEALQQQQTRLMK-- 203

Query: 176 VEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIG 223
           + H  R ++  V    +   +L  ++ E    L       G++RA++G
Sbjct: 204 INHDLRHRVTVVEAQGK---ALIEQKVELEADLQTKEQEMGSLRAELG 248



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 50/189 (26%), Positives = 84/189 (44%), Gaps = 25/189 (13%)

Query: 410 RDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVL---RGELEAAK 466
           RD+     +E+G    +   L + +  L  + +DL  +V  +  + + L   + ELEA  
Sbjct: 174 RDEIRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADL 233

Query: 467 QAKVK----LENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPM----A 518
           Q K +    L   + +L E L+   S+      E + E E V     ++++K+ M     
Sbjct: 234 QTKEQEMGSLRAELGKLRERLQGEHSQ----NGEEEPETEPVGEESISDAEKVAMDLKDP 289

Query: 519 QRRRFTRVEMARVLMERNQYKERLMELQEAVRW---TEMIRASR-------EHPSVQEKK 568
            R RFT  E+  VL ERN+ K ++  LQE + +    EM   +R        HP    + 
Sbjct: 290 NRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEMEEENRIPQPPPIAHPRTSPQP 349

Query: 569 KSTIWQFFS 577
           +S I + FS
Sbjct: 350 ESGIKRLFS 358


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 91/510 (17%), Positives = 204/510 (40%), Gaps = 46/510 (9%)

Query: 88   EQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQI 147
            E+++ + +++K+   + EE+  +  +A E E ++ Q  VE    Q  + E +AK Y  ++
Sbjct: 1144 ERMVAELKKQKS---RVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200

Query: 148  SRLEERESEMKKEYNALHQR--HTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERP 205
              +   +   ++E   + Q     E  +  VE    +   Q+  N+ T  +L    K + 
Sbjct: 1201 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD 1260

Query: 206  TSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAAT 265
             SLN        +  ++  K     +   L    +   +   Q  + ++ E  +    A 
Sbjct: 1261 LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR 1320

Query: 266  PSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV------ 319
               T  +     +++P   V P+ ++       G+  ++ K+  E+   +  E+      
Sbjct: 1321 RKITEIQYTCRENALP---VCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRK 1377

Query: 320  ------QVTQEMRNVSIGMGSSDEWSD-VQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
                  ++T E+  + +   SS+E +  ++D +D T     C +  L+R   +       
Sbjct: 1378 AEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQA------E 1431

Query: 373  KAFGINTDSLYHELSTAGSEVIGDVDEGADLLG-EFSVRDDFFGMGKEVGNLLLENSQLL 431
            K +      L  +L+    +    + E +DL   + + + +   +  E G L  E  ++ 
Sbjct: 1432 KGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRIT 1491

Query: 432  ETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSE-- 489
                        L +++     E+E+ R ++   K   +K E   K  E+ L+ +K+E  
Sbjct: 1492 RAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLK-EQFEKSHEQLLQNIKAEKE 1550

Query: 490  ---AIIARREPKEEAEDVSSYLCTESDKIP--------MAQRRRFTRVEMARVLMERNQY 538
                I    E  E++ + +  L  + +++         M QR    + E   +++E+   
Sbjct: 1551 NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQR---IQAESENIVLEKQTI 1607

Query: 539  KERLMELQ-EAVRWTEMIRASREHPSVQEK 567
            ++R   L+ +A  + + +R++ EH   Q K
Sbjct: 1608 QQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 26/119 (21%), Positives = 52/119 (43%), Gaps = 6/119 (5%)

Query: 442  NDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEA 501
            +DL+ +      E   L G++   ++   +L+ +   +EEEL +V+  A    R+ +   
Sbjct: 1120 SDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNV 1179

Query: 502  EDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 560
            ED+S        KI      +  R E+  ++ E+   +  L  +++     E  RA+ E
Sbjct: 1180 EDIS------LQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVE 1232



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 35/151 (23%), Positives = 62/151 (41%), Gaps = 25/151 (16%)

Query: 52   VKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYER-EKALRRQAEEKFIE 110
            V+EL   +  V + L     E Q    ++ L +E++ +     E   K + +  E K I 
Sbjct: 1709 VQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVIT 1768

Query: 111  FED---------ALEQEK--------------KELQIQVEHYEFQTRQLELKAKNYADQI 147
              D         +L+QE               KEL+ Q++ Y  Q +Q +    N+  + 
Sbjct: 1769 ENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKC 1828

Query: 148  SRLEERESEMKKEYNALHQRHTEMIQTYVEH 178
             +LE+     K+E   L Q+  + I+ + EH
Sbjct: 1829 QKLEDELIAQKREVENLKQKMDQQIKEH-EH 1858


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 88/474 (18%), Positives = 184/474 (38%), Gaps = 33/474 (6%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVE-LELLR--EDNEQLLTQYEREKALRRQAE 105
            ++++ E    V+  +E  +   +E +E E   L L R  E+ ++   + ER+    R   
Sbjct: 1479 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1538

Query: 106  EKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
            E  +  +D + +   EL+      E     L  +     D+++  E+ +  ++    AL 
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1598

Query: 166  QRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK 225
             +H   +Q   E  E  + Q        E      RK+R  ++      +G +  ++  +
Sbjct: 1599 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQ 1657

Query: 226  LVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
            +  AG        G+ ++    +  Q +M E  +       S     S    S      +
Sbjct: 1658 MASAGQ-------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1710

Query: 286  TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV--------QVTQEMRNVSIGMGSSDE 337
                E L+   +     +  ++A++ RD    EV         + +E R +   +G  +E
Sbjct: 1711 EA--EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1768

Query: 338  WSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEV---I 394
              ++++   ++  L+      L +  S  T+    ++F    +S   +L     E+   +
Sbjct: 1769 --ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826

Query: 395  GDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGE 454
            G+ D GA    + ++      + +    L  E  + + +   +   +  L   V Q+  E
Sbjct: 1827 GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE 1886

Query: 455  QEV---LRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 505
            + V   LR +LE       +L+ +++E EEE  R ++     RR  + E EDV+
Sbjct: 1887 RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA----GRRRLQRELEDVT 1936



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)

Query: 79   ELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLEL 138
            ELEL+  + E  + + E E + + Q E+K       L+Q  +EL+  +E  E   ++L+L
Sbjct: 944  ELELVVSELEARVGE-EEECSRQMQTEKK------RLQQHIQELEAHLEAEEGARQKLQL 996

Query: 139  -------KAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
                   K K + + +  LE++ S++ KE   L  R  E      E  E+ K
Sbjct: 997  EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1048



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 31/137 (22%), Positives = 57/137 (41%), Gaps = 18/137 (13%)

Query: 52   VKELMPLVVNVLENLDS-----VLSENQEHEV--ELELLREDNEQLLTQYEREKALRRQA 104
            ++E    +    E+L+S       +E Q  ++  ELE LR + E  L     ++ LR + 
Sbjct: 1138 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR 1197

Query: 105  EEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISR-----------LEER 153
            E++  E +  LE+E +  +  V+    +  Q   +     +Q  R           LE  
Sbjct: 1198 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAE 1257

Query: 154  ESEMKKEYNALHQRHTE 170
             SE++ E ++L     E
Sbjct: 1258 VSELRAELSSLQTARQE 1274



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 21/131 (16%)

Query: 74   QEHEVELELLREDNEQLLTQYEREK----ALRRQAEEKFIEFED---ALEQEKKELQIQV 126
            Q+H  ELE   E  E    + + EK    A  ++ EE  +  ED    L +E+K L+ ++
Sbjct: 974  QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033

Query: 127  EHYEFQTRQLELKAKN-----------YADQISRLEERE---SEMKKEYNALHQRHTEMI 172
              +  Q  + E K K+            AD   RL + E    E++K    L    +E+ 
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093

Query: 173  QTYVEHIERSK 183
            +  VE  +R++
Sbjct: 1094 EQMVEQQQRAE 1104


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 88/474 (18%), Positives = 184/474 (38%), Gaps = 33/474 (6%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVE-LELLR--EDNEQLLTQYEREKALRRQAE 105
            ++++ E    V+  +E  +   +E +E E   L L R  E+ ++   + ER+    R   
Sbjct: 1471 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1530

Query: 106  EKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
            E  +  +D + +   EL+      E     L  +     D+++  E+ +  ++    AL 
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1590

Query: 166  QRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK 225
             +H   +Q   E  E  + Q        E      RK+R  ++      +G +  ++  +
Sbjct: 1591 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQ 1649

Query: 226  LVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
            +  AG        G+ ++    +  Q +M E  +       S     S    S      +
Sbjct: 1650 MASAGQ-------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1702

Query: 286  TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV--------QVTQEMRNVSIGMGSSDE 337
                E L+   +     +  ++A++ RD    EV         + +E R +   +G  +E
Sbjct: 1703 EA--EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1760

Query: 338  WSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEV---I 394
              ++++   ++  L+      L +  S  T+    ++F    +S   +L     E+   +
Sbjct: 1761 --ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818

Query: 395  GDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGE 454
            G+ D GA    + ++      + +    L  E  + + +   +   +  L   V Q+  E
Sbjct: 1819 GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE 1878

Query: 455  QEV---LRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 505
            + V   LR +LE       +L+ +++E EEE  R ++     RR  + E EDV+
Sbjct: 1879 RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA----GRRRLQRELEDVT 1928



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)

Query: 79   ELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLEL 138
            ELEL+  + E  + + E E + + Q E+K       L+Q  +EL+  +E  E   ++L+L
Sbjct: 936  ELELVVSELEARVGE-EEECSRQMQTEKK------RLQQHIQELEAHLEAEEGARQKLQL 988

Query: 139  -------KAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
                   K K + + +  LE++ S++ KE   L  R  E      E  E+ K
Sbjct: 989  EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1040



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 31/137 (22%), Positives = 57/137 (41%), Gaps = 18/137 (13%)

Query: 52   VKELMPLVVNVLENLDS-----VLSENQEHEV--ELELLREDNEQLLTQYEREKALRRQA 104
            ++E    +    E+L+S       +E Q  ++  ELE LR + E  L     ++ LR + 
Sbjct: 1130 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR 1189

Query: 105  EEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISR-----------LEER 153
            E++  E +  LE+E +  +  V+    +  Q   +     +Q  R           LE  
Sbjct: 1190 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAE 1249

Query: 154  ESEMKKEYNALHQRHTE 170
             SE++ E ++L     E
Sbjct: 1250 VSELRAELSSLQTARQE 1266



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 21/131 (16%)

Query: 74   QEHEVELELLREDNEQLLTQYEREK----ALRRQAEEKFIEFED---ALEQEKKELQIQV 126
            Q+H  ELE   E  E    + + EK    A  ++ EE  +  ED    L +E+K L+ ++
Sbjct: 966  QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025

Query: 127  EHYEFQTRQLELKAKN-----------YADQISRLEERE---SEMKKEYNALHQRHTEMI 172
              +  Q  + E K K+            AD   RL + E    E++K    L    +E+ 
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085

Query: 173  QTYVEHIERSK 183
            +  VE  +R++
Sbjct: 1086 EQMVEQQQRAE 1096


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 88/474 (18%), Positives = 184/474 (38%), Gaps = 33/474 (6%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVE-LELLR--EDNEQLLTQYEREKALRRQAE 105
            ++++ E    V+  +E  +   +E +E E   L L R  E+ ++   + ER+    R   
Sbjct: 1512 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1571

Query: 106  EKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
            E  +  +D + +   EL+      E     L  +     D+++  E+ +  ++    AL 
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1631

Query: 166  QRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK 225
             +H   +Q   E  E  + Q        E      RK+R  ++      +G +  ++  +
Sbjct: 1632 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQ 1690

Query: 226  LVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
            +  AG        G+ ++    +  Q +M E  +       S     S    S      +
Sbjct: 1691 MASAGQ-------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1743

Query: 286  TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV--------QVTQEMRNVSIGMGSSDE 337
                E L+   +     +  ++A++ RD    EV         + +E R +   +G  +E
Sbjct: 1744 EA--EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1801

Query: 338  WSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEV---I 394
              ++++   ++  L+      L +  S  T+    ++F    +S   +L     E+   +
Sbjct: 1802 --ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859

Query: 395  GDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGE 454
            G+ D GA    + ++      + +    L  E  + + +   +   +  L   V Q+  E
Sbjct: 1860 GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE 1919

Query: 455  QEV---LRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 505
            + V   LR +LE       +L+ +++E EEE  R ++     RR  + E EDV+
Sbjct: 1920 RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA----GRRRLQRELEDVT 1969



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)

Query: 79   ELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLEL 138
            ELEL+  + E  + + E E + + Q E+K       L+Q  +EL+  +E  E   ++L+L
Sbjct: 977  ELELVVSELEARVGE-EEECSRQMQTEKK------RLQQHIQELEAHLEAEEGARQKLQL 1029

Query: 139  -------KAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
                   K K + + +  LE++ S++ KE   L  R  E      E  E+ K
Sbjct: 1030 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1081



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 31/137 (22%), Positives = 57/137 (41%), Gaps = 18/137 (13%)

Query: 52   VKELMPLVVNVLENLDS-----VLSENQEHEV--ELELLREDNEQLLTQYEREKALRRQA 104
            ++E    +    E+L+S       +E Q  ++  ELE LR + E  L     ++ LR + 
Sbjct: 1171 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR 1230

Query: 105  EEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISR-----------LEER 153
            E++  E +  LE+E +  +  V+    +  Q   +     +Q  R           LE  
Sbjct: 1231 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAE 1290

Query: 154  ESEMKKEYNALHQRHTE 170
             SE++ E ++L     E
Sbjct: 1291 VSELRAELSSLQTARQE 1307



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 21/131 (16%)

Query: 74   QEHEVELELLREDNEQLLTQYEREK----ALRRQAEEKFIEFED---ALEQEKKELQIQV 126
            Q+H  ELE   E  E    + + EK    A  ++ EE  +  ED    L +E+K L+ ++
Sbjct: 1007 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066

Query: 127  EHYEFQTRQLELKAKN-----------YADQISRLEERE---SEMKKEYNALHQRHTEMI 172
              +  Q  + E K K+            AD   RL + E    E++K    L    +E+ 
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126

Query: 173  QTYVEHIERSK 183
            +  VE  +R++
Sbjct: 1127 EQMVEQQQRAE 1137


>gi|215982794 myosin VA isoform 2 [Homo sapiens]
          Length = 1828

 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 45/213 (21%), Positives = 94/213 (44%), Gaps = 33/213 (15%)

Query: 27   ERVSGLAGSIYREFERL------IHCYDEEV------VKELMPLVVNVLENLDSVLSENQ 74
            E+++ L G    E E+L      +   +EE       V  L   +  + ++L+   SE +
Sbjct: 948  EKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKK 1007

Query: 75   EHEVELELLREDNEQLLTQYEREKALRRQAEEKFI-----EFEDALEQEKKELQIQVEHY 129
              E   +  +++ EQL++  + E  L +Q +E        + ++  E  +K+L  + +  
Sbjct: 1008 CIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQL 1067

Query: 130  EFQTRQLELKAKNYADQISRLEERESEMKKEYNAL-------HQR----HTEMIQTYVEH 178
            E       L+ +N  ++ SRLEER  ++K+E   +       H+R    H+     Y+  
Sbjct: 1068 ELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFS 1127

Query: 179  IERSKMQQVGGNSQTESSLPGRRKERPTSLNVF 211
             E ++M+ +   ++  S      K+ P  +++F
Sbjct: 1128 SEIAEMEDIPSRTEEPS-----EKKVPLDMSLF 1155


>gi|215982791 myosin VA isoform 1 [Homo sapiens]
          Length = 1855

 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 45/213 (21%), Positives = 94/213 (44%), Gaps = 33/213 (15%)

Query: 27   ERVSGLAGSIYREFERL------IHCYDEEV------VKELMPLVVNVLENLDSVLSENQ 74
            E+++ L G    E E+L      +   +EE       V  L   +  + ++L+   SE +
Sbjct: 948  EKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKK 1007

Query: 75   EHEVELELLREDNEQLLTQYEREKALRRQAEEKFI-----EFEDALEQEKKELQIQVEHY 129
              E   +  +++ EQL++  + E  L +Q +E        + ++  E  +K+L  + +  
Sbjct: 1008 CIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQL 1067

Query: 130  EFQTRQLELKAKNYADQISRLEERESEMKKEYNAL-------HQR----HTEMIQTYVEH 178
            E       L+ +N  ++ SRLEER  ++K+E   +       H+R    H+     Y+  
Sbjct: 1068 ELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFS 1127

Query: 179  IERSKMQQVGGNSQTESSLPGRRKERPTSLNVF 211
             E ++M+ +   ++  S      K+ P  +++F
Sbjct: 1128 SEIAEMEDIPSRTEEPS-----EKKVPLDMSLF 1155


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 54/248 (21%), Positives = 103/248 (41%), Gaps = 16/248 (6%)

Query: 422 NLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE 481
           NL  EN +L+E   +L   K  +  ++     +     G+L + K+       +I++LE+
Sbjct: 64  NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKK-------QIEKLEQ 116

Query: 482 ELKRVKSEAIIARREPKEEAEDVSSYLCTESDKI---PMAQRRRFTRVEMARVLMERNQY 538
           ELKR KSE  + R +   ++ DVS   C    KI   P+   + ++  +   +  + N+ 
Sbjct: 117 ELKRCKSE--LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKE 174

Query: 539 KERLMELQEAVRWTEMIRASREHP-SVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVN 597
            E    L+  V+  +  +AS+  P +    +     Q  S +FS      P+     S  
Sbjct: 175 VEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQR 234

Query: 598 IHYKSPTTAGF---SQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHV 654
              +   +A +    Q    +   +  G R       D+ +S    +Q + Q +++R  +
Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKI 294

Query: 655 RNDDGRLQ 662
              + RLQ
Sbjct: 295 NELELRLQ 302



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 101/514 (19%), Positives = 206/514 (40%), Gaps = 59/514 (11%)

Query: 67   DSVLSENQEHEVELELLREDNEQLLTQYEREKA----LRRQAEE-----KFIEFE-DALE 116
            DS+  + +  E EL++  E+ E ++   E  KA    L+ Q EE     K  E +   L 
Sbjct: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209

Query: 117  QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYV 176
             EK+ L  Q++  + Q  +L+    ++   +   E+ E ++K+E     +   EM+Q  +
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE----SKTAVEMLQNQL 2265

Query: 177  EHIERSKMQQVGGN---SQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLV---PAG 230
            + +  +     G       TE SL    +E     N        + A    +L       
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325

Query: 231  DHWHLSDL--GQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPL 288
            +  H +DL  G++++       + E++ + Q  AA     +  +  T       A +  +
Sbjct: 2326 ESEHHADLLKGRVENLER----ELEIARTNQEHAALEAENSKGEVET-----LKAKIEGM 2376

Query: 289  NESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSI-GMGSSDEWSDVQDIIDS 347
             +SL+ L    V  ++ K        +  E     E+ N S   +    E   VQ    S
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKS 2436

Query: 348  TPELDMCPETRL----DRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADL 403
            +  ++M  +T+L    +R  +        KA   N  S    L    ++++  +DE    
Sbjct: 2437 STAMEML-QTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE---- 2491

Query: 404  LGEFSVRDDFFGMGKEVGNLLLE---NSQLLETKN-ALNVVKN------DLIAKVDQLSG 453
                  ++++  +   V  L+ E     Q LE K+  ++ +KN       L++K+ Q+ G
Sbjct: 2492 -----AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG 2546

Query: 454  EQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESD 513
            E ++ + +    +   V+LE +I+ L+ +   ++    + +   K    ++     T+ D
Sbjct: 2547 EHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE---LTKMD 2603

Query: 514  KIPMAQRRRFTRVEMARVLMERNQYKERLMELQE 547
            K+   ++      +   +  E ++  ++  ELQE
Sbjct: 2604 KMSFVEKVNKMTAKETELQREMHEMAQKTAELQE 2637



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 3/94 (3%)

Query: 64   ENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQ 123
            ENL + L + QE   ELE++    E +L + E+EK    Q +EK     + L+ + KEL 
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQEKV---QMKEKSSTAMEMLQTQLKELN 2451

Query: 124  IQVEHYEFQTRQLELKAKNYADQISRLEERESEM 157
             +V          + K +N + Q+  LE  ++++
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQL 2485



 Score = 39.3 bits (90), Expect = 0.026
 Identities = 38/187 (20%), Positives = 79/187 (42%), Gaps = 22/187 (11%)

Query: 35  SIYREFERLIHCYDEEVVKELMPLVVNVLE---NLDSVLSENQEHEVE-----LELLRED 86
           ++ R+ +  I+  +  +  E + L V  LE   +    L + +EH +E     L    ++
Sbjct: 535 TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594

Query: 87  NEQLLTQYEREKALRRQAEEKFIEFE----------DALEQEKKELQIQVEHYEFQTRQL 136
           ++ LL+  E +K    + +E+   F             +E EK+ LQ ++ H E   +  
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654

Query: 137 ELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESS 196
           ++K+  Y +++  LE     +  E   LH     ++ +    +E  K+  +    + E S
Sbjct: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLH----NVLDSKSVEVETQKLAYMELQQKAEFS 710

Query: 197 LPGRRKE 203
               +KE
Sbjct: 711 DQKHQKE 717



 Score = 37.4 bits (85), Expect = 0.097
 Identities = 25/122 (20%), Positives = 54/122 (44%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
            E+ ++ L     ++ + L+ + S  +  E ELEL + D    + +  +  A   + + + 
Sbjct: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625

Query: 109  IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRH 168
             E      + ++EL  +      + + L  + K+  DQ+  L    SE+KK  + +H+  
Sbjct: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685

Query: 169  TE 170
             E
Sbjct: 2686 VE 2687



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 110/591 (18%), Positives = 239/591 (40%), Gaps = 120/591 (20%)

Query: 60   VNVLENLDSVLSENQ--EHEVELELLREDNEQLLTQYEREKALRRQAEE----------K 107
            +++L NL+  +S NQ    EV    L+E+N   LT+ E   A  +  EE           
Sbjct: 1506 MSLLSNLEGAVSANQCSVDEVFCSSLQEEN---LTRKETPSAPAKGVEELESLCEVYRQS 1562

Query: 108  FIEFEDALEQE----KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYN- 162
              + E+ +E +     KE+Q   +    + ++L+   K Y  +  + +++ + +  E   
Sbjct: 1563 LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMES 1622

Query: 163  --ALHQRHTEMIQTYVEHIERSKMQQVGGNSQ------TESSLPGRRK------------ 202
              A  ++ TE +   +E + R ++Q +  +S+      TE ++ GR +            
Sbjct: 1623 KLAAEKKQTEQLSLELE-VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSET 1681

Query: 203  -ERPTSLNVFPLADGTVRAQIG---------GKLVPAGDHWHLSDLGQLQSSSSYQCPQD 252
             ER    +V  + D   +  +          G + P G+       G+    ++Y+ P +
Sbjct: 1682 TERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGEC-----SGEQSPDTNYEPPGE 1736

Query: 253  EMSESGQSSAAATPSTTGTKSNTPTS---------SVPSAAVTPLNESLQPLGDYGVGSK 303
            + ++ G S   +  S +G  +  P           ++        NE+L+ L       +
Sbjct: 1737 DKTQ-GSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVI----E 1791

Query: 304  NSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTG 363
            +  R  E   +   E+     ++ V + M   +   +++ I+    + +     +L+   
Sbjct: 1792 DRDRKVESLLNEMKELDSKLHLQEVQL-MTKIEACIELEKIVGELKKENSDLSEKLEYFS 1850

Query: 364  SSPTQGI--VNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVG 421
                + +  V  + G+N+D   H   ++  ++  +V +  D     S ++ F  +  E+ 
Sbjct: 1851 CDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND-----SWKERFLDVENELS 1905

Query: 422  NLLLENSQL----LETKNALNVVKNDLIA-----------------KVDQLSGEQEVLRG 460
             +  E + +    L  +  L VV+ + +                  ++  ++ E+  LRG
Sbjct: 1906 RIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG 1965

Query: 461  ELEAAKQ---AKVKLENRIKELEEELKRVKSEAI----IARREPKEEAE-------DVSS 506
            EL+   +   A  +L  ++KE  +EL+  +SE +    +A  E KE+ E       DVS 
Sbjct: 1966 ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSE 2025

Query: 507  YLCTES---DKIPM----AQRRRFTRVEMARVLMERNQYKERLMELQEAVR 550
             L  ++   +K+      +Q    T+ E+   + + N+ KE L++  E+++
Sbjct: 2026 LLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2076



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 38/145 (26%), Positives = 65/145 (44%), Gaps = 18/145 (12%)

Query: 445  IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEE-------LKRVKSEAIIARREP 497
            I +  QL    E LR  LEA ++ ++ +  ++KE E         ++ ++ E  IAR   
Sbjct: 2293 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352

Query: 498  KE---EAEDVSSYLCTESDKIP-MAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTE 553
            +    EAE+    + T   KI  M Q  R   +++  +  E+      L + QE +   E
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412

Query: 554  MIRAS-------REHPSVQEKKKST 571
            +I +S       +E   VQ K+KS+
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSS 2437



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 101/523 (19%), Positives = 196/523 (37%), Gaps = 91/523 (17%)

Query: 95  EREKALRRQAEEKFIEFE---DALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ---IS 148
           E ++ L  +A +K  E E   D L++EK++ Q Q++  E   ++ + K +N   +   + 
Sbjct: 7   EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66

Query: 149 RLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSL 208
           R  +R  E+ +      Q+ +  +Q     +   + Q   G  Q E  L    K   + L
Sbjct: 67  RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK-LEQELKRCKSEL 125

Query: 209 NVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPST 268
                A  +    +     P           Q  S S Y+  +++ ++  +         
Sbjct: 126 ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185

Query: 269 TGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVG----------SKNSKRAREKRDSRNME 318
              ++   + ++P A +   + +                    S NS+R   +RD     
Sbjct: 186 KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245

Query: 319 VQVTQEMR--NVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFG 376
               QE+     ++ +G  D  S   D   S   LD            +  Q + NK   
Sbjct: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQL---------KAQNQELRNKINE 296

Query: 377 INTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENS--QLLETK 434
           +      HE      E+ G V++  +L                   L LE +  +L+E +
Sbjct: 297 LELRLQGHE-----KEMKGQVNKFQEL------------------QLQLEKAKVELIEKE 333

Query: 435 NALNVVKNDLI---AKVDQLSGEQEVLRGELEA-----------AKQAKVKLENRIKELE 480
             LN  +++L+   A+ DQ S +   L  +L+            A+ A+  LE +IKE E
Sbjct: 334 KVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE 393

Query: 481 ----EELKR-------VKSEAIIAR---REPKEEAEDVSSYLCTESDKIPMAQRRRFTRV 526
               EEL R       +  E I  +    +  ++A+++ + L  E DK+   +++    +
Sbjct: 394 KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453

Query: 527 EMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKK 569
           E         ++K++L   ++A +    I+ +    S++E KK
Sbjct: 454 E---------EFKQKLCRAEQAFQ-ASQIKENELRRSMEEMKK 486



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 13/109 (11%)

Query: 66  LDSVLSENQEHEVELELLREDNEQLLTQYEREKA----LRRQAEEKFIEFEDALEQEKK- 120
           LD +  E Q+ + +L+ L    ++   + E EK     L+R+  ++ +E  ++LE+ K+ 
Sbjct: 27  LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE-NQRLMEICESLEKTKQK 85

Query: 121 ---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
              ELQ++     FQ  QL    K    QI +LE+     K E     Q
Sbjct: 86  ISHELQVKESQVNFQEGQLNSGKK----QIEKLEQELKRCKSELERSQQ 130



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 27/123 (21%), Positives = 55/123 (44%), Gaps = 12/123 (9%)

Query: 60   VNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEK 119
            +NV + L++ L E  E  + L   +E+  QL    E+ +      E+K +   + L++ +
Sbjct: 2087 LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERE 2146

Query: 120  KELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
            +E     +  E   R+L++  +N    I   E  ++E+            E ++T +E +
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEV------------ETLKTQIEEM 2194

Query: 180  ERS 182
             RS
Sbjct: 2195 ARS 2197



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 34/168 (20%), Positives = 68/168 (40%), Gaps = 9/168 (5%)

Query: 36  IYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYE 95
           I R+F       ++EV      L +    + +S   +N      L+ L+  N++L  +  
Sbjct: 237 IRRDFSASYFSGEQEVTPSRSTLQIGK-RDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295

Query: 96  REKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES 155
            E  LR Q  EK ++ +     + +ELQ+Q+E  + +  + E       D++ R   +  
Sbjct: 296 -ELELRLQGHEKEMKGQ---VNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351

Query: 156 EMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKE 203
           +   +Y AL Q+    ++   E +   +          E  +  + KE
Sbjct: 352 QASTKYTALEQK----LKKLTEDLSCQRQNAESARCSLEQKIKEKEKE 395



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 51/225 (22%), Positives = 92/225 (40%), Gaps = 24/225 (10%)

Query: 64   ENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQ 123
            E L++ L    +   EL+  + DN + + Q ++E    +   +  I+    LE+EK+ LQ
Sbjct: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813

Query: 124  IQVEHYE-FQTRQ-----LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVE 177
             ++   +  Q +Q     ++ K      +I  L+E   E  KE +    ++  ++ ++ E
Sbjct: 2814 KELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH-E 2872

Query: 178  HIERSKMQ---QVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWH 234
             +E++K     QV      +S    R           PL    V    G   +P+     
Sbjct: 2873 KLEKAKEMLETQVAHLCSQQSKQDSRGS---------PLLGPVVP---GPSPIPSVTEKR 2920

Query: 235  LSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSS 279
            LS  GQ ++S   Q     + E+G+    ATP +   KS     S
Sbjct: 2921 LSS-GQNKASGKRQ-RSSGIWENGRGPTPATPESFSKKSKKAVMS 2963



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 49/212 (23%), Positives = 91/212 (42%), Gaps = 39/212 (18%)

Query: 136  LELKAKNYADQISRLEERESEMKKEYNALHQRHTEM------IQTYVEHIE------RSK 183
            L L  K      + L+E+   ++ E+  LH +H +M      +QTYV+ ++       + 
Sbjct: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTN 1452

Query: 184  MQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK------LVPAGDHWHLSD 237
            ++   G+   E  L G  +    SL+   + D +  + +G        L   GD   LS+
Sbjct: 1453 LRNFQGDLVKEMQL-GLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSN 1511

Query: 238  LGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGD 297
            L    S++  QC  DE+        ++      T+  TP  S P+  V    E L+ L +
Sbjct: 1512 LEGAVSAN--QCSVDEV------FCSSLQEENLTRKETP--SAPAKGV----EELESLCE 1557

Query: 298  YGVGSKNSKRAREKRDS----RNMEVQVTQEM 325
              V  ++ ++  EK +S    +N E+Q  +++
Sbjct: 1558 --VYRQSLEKLEEKMESQGIMKNKEIQELEQL 1587



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 33/221 (14%)

Query: 352  DMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRD 411
            +  P+T  +  G   TQG         +     ELS +G   +              V  
Sbjct: 1724 EQSPDTNYEPPGEDKTQG---------SSECISELSFSGPNAL--------------VPM 1760

Query: 412  DFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAK----- 466
            DF G  +++ NL L   +       L  V  D   KV+ L  E + L  +L   +     
Sbjct: 1761 DFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMT 1820

Query: 467  --QAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFT 524
              +A ++LE  + EL++E   +  +      + +E  + V +     SD    A +   +
Sbjct: 1821 KIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKS--S 1878

Query: 525  RVEMA-RVLMERNQYKERLMELQEAVRWTEMIRASREHPSV 564
            R ++   V    + +KER ++++  +      +AS EH ++
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919


>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
          Length = 749

 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 31/112 (27%), Positives = 56/112 (50%), Gaps = 7/112 (6%)

Query: 72  ENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEF 131
           E +E   + EL R+  E+L  +   E+  RR+ E + +E E A E+E ++LQ Q E    
Sbjct: 497 EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKE-EQLQRQAEERAL 555

Query: 132 QTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
           + R+   +A+   ++ +R+ E    +++E     QR  +      E +ER K
Sbjct: 556 REREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ------ERLERKK 601



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 14/108 (12%)

Query: 450 QLSGEQEVLRGELEA----AKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 505
           Q   E+   R E E+    A+QA+ K E   ++ EE   R + EA  A+R+ +EEA    
Sbjct: 517 QRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEAR--- 573

Query: 506 SYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTE 553
             +  E++++   + + F R E      ER + K+RL E+ +  R TE
Sbjct: 574 --VREEAERVRQEREKHFQREE-----QERLERKKRLEEIMKRTRRTE 614



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 50/251 (19%), Positives = 108/251 (43%), Gaps = 31/251 (12%)

Query: 82  LLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAK 141
           +LR D+ Q L +  RE+  ++ A  + +     LE+E++  Q   +H E + ++LE + +
Sbjct: 60  VLRVDDRQRLARERREEREKQLAAREIVW----LEREERARQHYEKHLEERKKRLEEQRQ 115

Query: 142 NYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ--------QVGGNSQT 193
               + + +EE+  +  +E     +RH  +++  +E  ++ K +         + G+   
Sbjct: 116 KEERRRAAVEEKRRQRLEEDK---ERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSI 172

Query: 194 ESSLPGRRKERPTSLNVFPLADGTVRAQIGGK---LVPAGDH--------WHLSDLGQLQ 242
            S+ P RR    +++N+    D  +  ++      L+ + D         W  S + +L 
Sbjct: 173 HSADPDRRS--VSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLL 230

Query: 243 S-SSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSV--PSAAVTPLNESLQPLGDYG 299
           + + S+       +     +A+ +P     K+    +S+  P   VTP   S +    +G
Sbjct: 231 TPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHG 290

Query: 300 VGSKNSKRARE 310
             S   +R RE
Sbjct: 291 TASYKKERERE 301



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 34/165 (20%), Positives = 65/165 (39%), Gaps = 12/165 (7%)

Query: 77  EVELELLREDNEQLLTQYEREKALRRQAEE----------KFIEFEDALEQEKKELQIQV 126
           E    LL E       Q E+E+  RR+ EE          + +  E    +E++  +++ 
Sbjct: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536

Query: 127 EHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQ 186
           E    +  QL+ +A+  A +     ER    K+E   + +    + Q   +H +R + ++
Sbjct: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596

Query: 187 VGGNSQTESSLPGRRKERPTSLNVFPLADGTVR--AQIGGKLVPA 229
           +    + E  +   R+   T        +G +   A  GG  V A
Sbjct: 597 LERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSA 641



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 13/122 (10%)

Query: 38  REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYERE 97
           RE E L     EE+ + +        E     L   Q  E E +L R+  E+ L + E  
Sbjct: 502 REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561

Query: 98  KALRRQAEEKFIEFEDA-------------LEQEKKELQIQVEHYEFQTRQLELKAKNYA 144
           +  +RQ EE+    E+A              EQE+ E + ++E    +TR+ E   K  +
Sbjct: 562 ERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTS 621

Query: 145 DQ 146
           DQ
Sbjct: 622 DQ 623


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 107/543 (19%), Positives = 211/543 (38%), Gaps = 56/543 (10%)

Query: 67   DSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQV 126
            D  L +N   +V  EL  +  E L   +E EKA R +AE++  +  + LE  K EL+  +
Sbjct: 1101 DETLHKNNALKVVRELQAQIAE-LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159

Query: 127  EHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQ 186
            +    Q      + +  A+    LEE     + +   + QRH   ++   E +E++K  +
Sbjct: 1160 DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219

Query: 187  VGGNSQTESSLPGRRKERPTSLNVFPLADGT---VRAQIGGKLVPAGDHWHLSDLGQLQS 243
                 + +  L    KE    + V           R ++  ++     H  +S+  +L+ 
Sbjct: 1220 -ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL--HAKVSEGDRLRV 1276

Query: 244  SSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSK 303
              + +  + +      S+        G K     +S+ S     L ++ + L +      
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES----QLQDTQELLQEETRQKL 1332

Query: 304  N-SKRAREKRDSRNM---------EVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDM 353
            N S R R+  + +N          E +   E + +++    +D    V D + +   L+ 
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392

Query: 354  CPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDE-GADLLGEFSVRDD 412
              + +L +   + +Q +  KA        Y +L    + +  ++D+   DL  +  V  +
Sbjct: 1393 A-KKKLLKDAEALSQRLEEKALA------YDKLEKTKNRLQQELDDLTVDLDHQRQVASN 1445

Query: 413  FFGMGKEVGNLLLENSQL-----------------LETKNALNVVK--NDLIAKVDQLSG 453
                 K+   LL E   +                  ETK AL++ +   + +   ++   
Sbjct: 1446 LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETK-ALSLARALEEALEAKEEFER 1504

Query: 454  EQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESD 513
            + + LR ++E    +K  +   + ELE+  KR   + +   R   EE ED      TE  
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKS-KRALEQQVEEMRTQLEELED--ELQATEDA 1561

Query: 514  KIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHP-SVQEKKK 569
            K+ +    +  + +  R L    E+N+ K+RL+  Q      E+    ++   +V  KKK
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621

Query: 570  STI 572
              I
Sbjct: 1622 MEI 1624



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 101/540 (18%), Positives = 203/540 (37%), Gaps = 70/540 (12%)

Query: 41   ERLIHCYDEEV--VKELMPLVVNVLENLD----------SVLSENQEHEVELELLREDNE 88
            E  +   DEE+  VKE    V   LE ++          ++L+E  + E EL    E+  
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910

Query: 89   QLLTQYERE-KALRRQAEEKFIEFEDA---LEQEKKELQIQVEHYEFQTRQ--------- 135
              L   ++E + +    E +  E E+    L+ EKK++Q  ++  E Q  +         
Sbjct: 911  ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970

Query: 136  -----LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGN 190
                  E K K   ++I  LE++ S+  KE   +  R  E      E  E++K      N
Sbjct: 971  LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030

Query: 191  SQTE--SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSS-SSY 247
             Q    S L  R K+   +      A    + ++ G+     D      + +LQ+     
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKA----KRKLDGETTDLQD-----QIAELQAQIDEL 1081

Query: 248  QCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKR 307
            +    +  E  Q + A     T  K+N         A+  + E    + +     ++ K 
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNN---------ALKVVRELQAQIAELQEDFESEKA 1132

Query: 308  AREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPT 367
            +R K + +  +  +++E+  +          ++++D +D+T       E R  R      
Sbjct: 1133 SRNKAEKQKRD--LSEELEALK---------TELEDTLDTTAAQQ---ELRTKREQEVAE 1178

Query: 368  QGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLEN 427
                 +    N ++   ++    +  + ++ E  +    F        + K    L  +N
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA-----NLEKNKQGLETDN 1233

Query: 428  SQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVK 487
             +L      L  VK +   K  +L  + + L  ++    + +V+L  +  +L+ EL  V 
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293

Query: 488  SEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQE 547
            +    A ++  + A+D +S      D   + Q     ++ ++  + +  + K  L E QE
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 95/486 (19%), Positives = 189/486 (38%), Gaps = 57/486 (11%)

Query: 49   EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLT---QYERE-KALRRQA 104
            ++++ E   +     E  D   +E +E E +   L    E+ L    ++ER+ K LR   
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513

Query: 105  EEKFIEFEDA------LEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMK 158
            E+     +D       LE+ K+ L+ QVE    Q  +LE       D++   E+ +  ++
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE-------DELQATEDAKLRLE 1566

Query: 159  KEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSL-----NVFPL 213
                A+  +    +QT  E  E  K   +    + E+ L   RK+R  ++         L
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626

Query: 214  ADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKS 273
             D   + +   K   A D   +  L +LQ+       +D   E  ++ A+       +K 
Sbjct: 1627 KDLEAQIEAANK---ARDE-VIKQLRKLQAQM-----KDYQRELEEARASRDEIFAQSKE 1677

Query: 274  NTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKR-AREKRDSRNMEV--------QVTQE 324
            +        A +  L E L         S+ ++R A ++RD    E+         +  E
Sbjct: 1678 SEKKLKSLEAEILQLQEEL-------ASSERARRHAEQERDELADEITNSASGKSALLDE 1730

Query: 325  MRNVSIGMGSSDEWSDVQDIIDSTPEL--DMCPETRLDRTGSSPTQGIVNKAFGINTDSL 382
             R +   +   +E  + +    S  EL  D   +T L +  +   +    ++    +D+ 
Sbjct: 1731 KRRLEARIAQLEEELEEE---QSNMELLNDRFRKTTL-QVDTLNAELAAERSAAQKSDNA 1786

Query: 383  YHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKN 442
              +L     E+   + E    + +   +     +  ++G L  +  Q  + + A N +  
Sbjct: 1787 RQQLERQNKELKAKLQELEGAV-KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845

Query: 443  DLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIA---RREPKE 499
                K+ ++  + E  R   +  K+   K   R+K+L+ +L+  + EA  A   RR+ + 
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905

Query: 500  EAEDVS 505
            E +D +
Sbjct: 1906 ELDDAT 1911



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 103/510 (20%), Positives = 200/510 (39%), Gaps = 62/510 (12%)

Query: 48   DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
            +EE  K L   V+ +   L     +  +    +E L E  ++LL   E   AL ++ EEK
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE---ALSQRLEEK 1411

Query: 108  FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQR 167
             + + D LE+ K  LQ +++        L +   +     S LE+++    K+++ L   
Sbjct: 1412 ALAY-DKLEKTKNRLQQELD-------DLTVDLDHQRQVASNLEKKQ----KKFDQLLAE 1459

Query: 168  HTEMIQTYVEHIERSKMQQVGGNSQTES-SLPGRRKERPTSLNVFPLADGTVRAQIGGKL 226
               +   Y E  ER + +      +T++ SL    +E   +   F   +  +RA +   +
Sbjct: 1460 EKSISARYAE--ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517

Query: 227  VPAGDHWHLSDLGQLQSSS-SYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
                D     ++ +L+ S  + +   +EM    +       +T   K     +    A  
Sbjct: 1518 SSKDDVG--KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM--QAMK 1573

Query: 286  TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWS-DVQDI 344
                  LQ   +    ++  KR   K+  R +E ++  E +  ++ + S  +   D++D+
Sbjct: 1574 AQFERDLQTRDEQ---NEEKKRLLIKQ-VRELEAELEDERKQRALAVASKKKMEIDLKDL 1629

Query: 345  IDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLL 404
                       E +++           NKA     D +  +L    +++    D   +L 
Sbjct: 1630 -----------EAQIEAA---------NKA----RDEVIKQLRKLQAQM---KDYQRELE 1662

Query: 405  GEFSVRDDFFGMGKE----VGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRG 460
               + RD+ F   KE    + +L  E  QL E   +    +     + D+L+ E      
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSAS 1722

Query: 461  ELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQR 520
               A    K +LE RI +LEEEL+  +S   +     ++    V +     + +   AQ+
Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK 1782

Query: 521  RRFTRVEMARVLMERNQYKERLMELQEAVR 550
                R ++ R   +  + K +L EL+ AV+
Sbjct: 1783 SDNARQQLER---QNKELKAKLQELEGAVK 1809



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 12/130 (9%)

Query: 426  ENSQLLET-KNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEE-- 482
            E +Q+L+  K  +     DL  ++D+  G ++ L+ E       KV  E +IK++EEE  
Sbjct: 936  ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE-------KVTAEAKIKKMEEEIL 988

Query: 483  -LKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKER 541
             L+   S+ I  ++  ++   + SS L  E +K     + R  +  M   L ER + +E+
Sbjct: 989  LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048

Query: 542  L-MELQEAVR 550
               EL++A R
Sbjct: 1049 TRQELEKAKR 1058



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 47/209 (22%), Positives = 85/209 (40%), Gaps = 40/209 (19%)

Query: 385  ELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMG---KEV---GNLLLENSQLLETKNALN 438
            EL  A  ++ G+  +  D + E   + D   +    KE    G L   + + L   NAL 
Sbjct: 1052 ELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALK 1111

Query: 439  VVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSE------AII 492
            VV+        +L  +   L+ + E+ K ++ K E + ++L EEL+ +K+E         
Sbjct: 1112 VVR--------ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163

Query: 493  ARREPKEEAEDVSSYLCT---------ESDKIPMAQRRRFTRVEMARVLMERNQYKERL- 542
            A++E + + E   + L           E+    M QR      E++  L +  ++K  L 
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223

Query: 543  ----------MELQEAVRWTEMIRASREH 561
                       EL   V+  + ++A  EH
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEH 1252



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 43/175 (24%), Positives = 78/175 (44%), Gaps = 34/175 (19%)

Query: 419  EVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKE 478
            ++ +L+     + +  + L   K  L  +V+++  + E L  EL+A + AK++LE  ++ 
Sbjct: 1512 DMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA 1571

Query: 479  LEEELKR----------VKSEAIIAR-REPKEEAED--------VSSYLCTESD------ 513
            ++ + +R           K   +I + RE + E ED        V+S    E D      
Sbjct: 1572 MKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA 1631

Query: 514  KIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKK 568
            +I  A + R   ++  R L  + Q K+   EL+EA       RASR+    Q K+
Sbjct: 1632 QIEAANKARDEVIKQLRKL--QAQMKDYQRELEEA-------RASRDEIFAQSKE 1677


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,079,328
Number of Sequences: 37866
Number of extensions: 3136784
Number of successful extensions: 24696
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 283
Number of HSP's successfully gapped in prelim test: 1067
Number of HSP's that attempted gapping in prelim test: 15792
Number of HSP's gapped (non-prelim): 8446
length of query: 1336
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1222
effective length of database: 13,930,794
effective search space: 17023430268
effective search space used: 17023430268
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.