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Search of human proteins with 94538366
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94538366 transient receptor potential cation channel,
subfamily M, member 1 [Homo sapiens]
(1603 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94538366 transient receptor potential cation channel, subfami... 3214 0.0
gi|154091308 transient receptor potential cation channel, subfam... 1234 0.0
gi|154091320 transient receptor potential cation channel, subfam... 1234 0.0
gi|154091314 transient receptor potential cation channel, subfam... 1234 0.0
gi|154091312 transient receptor potential cation channel, subfam... 1225 0.0
gi|154091310 transient receptor potential cation channel, subfam... 1207 0.0
gi|154091318 transient receptor potential cation channel, subfam... 1207 0.0
gi|154091316 transient receptor potential cation channel, subfam... 1198 0.0
gi|148612863 transient receptor potential cation channel, subfam... 1169 0.0
gi|18921093 transient receptor potential cation channel, subfami... 831 0.0
gi|45935368 transient receptor potential cation channel, subfami... 411 e-114
gi|55953096 transient receptor potential cation channel, subfami... 397 e-110
gi|11225266 transient receptor potential cation channel, subfami... 316 1e-85
gi|21314671 transient receptor potential cation channel, subfami... 313 9e-85
gi|4507689 transient receptor potential cation channel, subfamil... 297 6e-80
gi|109689695 transient receptor potential cation channel, subfam... 253 8e-67
gi|209863026 transient receptor potential cation channel, subfam... 89 4e-17
gi|209863030 transient receptor potential cation channel, subfam... 88 6e-17
gi|7706747 transient receptor potential cation channel, subfamil... 88 6e-17
gi|209863032 transient receptor potential cation channel, subfam... 87 1e-16
gi|209863024 transient receptor potential cation channel, subfam... 87 2e-16
gi|6912736 transient receptor potential cation channel, subfamil... 85 6e-16
gi|209863028 transient receptor potential cation channel, subfam... 78 8e-14
gi|5730102 transient receptor potential cation channel, subfamil... 65 5e-10
gi|194733735 transient receptor potential cation channel, subfam... 63 3e-09
gi|4507687 transient receptor potential cation channel, subfamil... 63 3e-09
gi|9966865 transient receptor potential cation channel, subfamil... 61 8e-09
gi|4507685 transient receptor potential cation channel, subfamil... 58 8e-08
gi|21735483 transient receptor potential cation channel, subfami... 49 4e-05
gi|21314682 transient receptor potential cation channel, subfami... 46 3e-04
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 3214 bits (8334), Expect = 0.0
Identities = 1603/1603 (100%), Positives = 1603/1603 (100%)
Query: 1 MKDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLE 60
MKDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLE
Sbjct: 1 MKDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLE 60
Query: 61 FQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVF 120
FQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVF
Sbjct: 61 FQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVF 120
Query: 121 GKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDL 180
GKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDL
Sbjct: 121 GKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDL 180
Query: 181 VGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKIN 240
VGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKIN
Sbjct: 181 VGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKIN 240
Query: 241 TRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGG 300
TRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGG
Sbjct: 241 TRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGG 300
Query: 301 IINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAIL 360
IINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAIL
Sbjct: 301 IINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAIL 360
Query: 361 TALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPP 420
TALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPP
Sbjct: 361 TALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPP 420
Query: 421 MATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLL 480
MATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLL
Sbjct: 421 MATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLL 480
Query: 481 IENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYL 540
IENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYL
Sbjct: 481 IENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYL 540
Query: 541 MGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDV 600
MGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDV
Sbjct: 541 MGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDV 600
Query: 601 DDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESD 660
DDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESD
Sbjct: 601 DDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESD 660
Query: 661 LVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKH 720
LVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKH
Sbjct: 661 LVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKH 720
Query: 721 RDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKEN 780
RDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKEN
Sbjct: 721 RDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKEN 780
Query: 781 EDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLG 840
EDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLG
Sbjct: 781 EDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLG 840
Query: 841 YLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWN 900
YLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWN
Sbjct: 841 YLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWN 900
Query: 901 ITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIG 960
ITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIG
Sbjct: 901 ITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIG 960
Query: 961 KMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQID 1020
KMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQID
Sbjct: 961 KMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQID 1020
Query: 1021 LYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFF 1080
LYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFF
Sbjct: 1021 LYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFF 1080
Query: 1081 EVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERD 1140
EVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERD
Sbjct: 1081 EVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERD 1140
Query: 1141 RGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEIN 1200
RGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEIN
Sbjct: 1141 RGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEIN 1200
Query: 1201 ERETFMKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSECEATYLLR 1260
ERETFMKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSECEATYLLR
Sbjct: 1201 ERETFMKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSECEATYLLR 1260
Query: 1261 QSSINSADGYSLYRYHFNGEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPEC 1320
QSSINSADGYSLYRYHFNGEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPEC
Sbjct: 1261 QSSINSADGYSLYRYHFNGEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPEC 1320
Query: 1321 QNSLHLSLGTSTSATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPS 1380
QNSLHLSLGTSTSATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPS
Sbjct: 1321 QNSLHLSLGTSTSATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPS 1380
Query: 1381 LNKTDVIHGQDKSDVQNTQLTVETTNIEGTISYPLEETKITRYFPDETINACKTMKSRSF 1440
LNKTDVIHGQDKSDVQNTQLTVETTNIEGTISYPLEETKITRYFPDETINACKTMKSRSF
Sbjct: 1381 LNKTDVIHGQDKSDVQNTQLTVETTNIEGTISYPLEETKITRYFPDETINACKTMKSRSF 1440
Query: 1441 VYSRGRKLVGGVNQDVEYSSITDQQLTTEWQCQVQKITRSHSTDIPYIVSEAAVQAEHKE 1500
VYSRGRKLVGGVNQDVEYSSITDQQLTTEWQCQVQKITRSHSTDIPYIVSEAAVQAEHKE
Sbjct: 1441 VYSRGRKLVGGVNQDVEYSSITDQQLTTEWQCQVQKITRSHSTDIPYIVSEAAVQAEHKE 1500
Query: 1501 QFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSVKPDQTLGFPSLRSKSLHGHPRNV 1560
QFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSVKPDQTLGFPSLRSKSLHGHPRNV
Sbjct: 1501 QFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSVKPDQTLGFPSLRSKSLHGHPRNV 1560
Query: 1561 KSIQGKLDRSGHASSVSSLVIVSGMTAEEKKVKKEKASTETEC 1603
KSIQGKLDRSGHASSVSSLVIVSGMTAEEKKVKKEKASTETEC
Sbjct: 1561 KSIQGKLDRSGHASSVSSLVIVSGMTAEEKKVKKEKASTETEC 1603
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 1234 bits (3192), Expect = 0.0
Identities = 684/1204 (56%), Positives = 829/1204 (68%), Gaps = 102/1204 (8%)
Query: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 355 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 414
Query: 518 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMED 577
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPKRPKALKLLGMED
Sbjct: 415 KKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMED 474
Query: 578 DEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE 637
D P +G+K KK+ EEE+DID+DDP ++ F +PFHELMVWAVLMKRQKMA+F WQ GEE
Sbjct: 475 DIPLRRGRKTTKKR-EEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEE 533
Query: 638 SMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMK 697
+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLDQSYK DEQ+AMK
Sbjct: 534 AMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 593
Query: 698 LLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILL 757
LLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN GLKVI+GILL
Sbjct: 594 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 653
Query: 758 PPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDANADAG------S 799
PP+IL LEF+ DD Y + KE E+ KEKEEE+ + A G S
Sbjct: 654 PPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESS 713
Query: 800 RKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSL 859
RK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY++LV+M+ WPS
Sbjct: 714 RKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPST 773
Query: 860 QEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQ 919
QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI F +G ILRLQ
Sbjct: 774 QEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQ 833
Query: 920 NQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMS 979
+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+YFV+IMLVVLMS
Sbjct: 834 DQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMS 893
Query: 980 FGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEG 1039
FGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID PPCG+N E+G
Sbjct: 894 FGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID-------PPCGQNETREDG 946
Query: 1040 K--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 1097
K +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL
Sbjct: 947 KIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 1006
Query: 1098 IMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHE 1157
IMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKLF++D+ELK++H+
Sbjct: 1007 IMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKLFITDDELKKVHD 1065
Query: 1158 FEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRL 1217
FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE MK SLQTVD+RL
Sbjct: 1066 FEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRL 1125
Query: 1218 AQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSINSADGYSLYRYH 1276
AQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS NS +G +
Sbjct: 1126 AQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNT----- 1180
Query: 1277 FNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHLVPECQNSLHLSL 1328
F +E + E+T TSP R ++ SF KD + E SLH +
Sbjct: 1181 FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRAT 1240
Query: 1329 GTSTSA---------------TPDGS----------------HLAVDDLKNA-------E 1350
+ + A PD H +D L N+ E
Sbjct: 1241 SSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGE 1300
Query: 1351 ESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTN---I 1407
S P + T + + S S++ D+ +S + E N
Sbjct: 1301 PSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDS 1360
Query: 1408 EGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVNQDV---EYSSIT 1462
E + + +E +K +RY + +KS SF++S R V EY+SIT
Sbjct: 1361 EPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSIT 1420
Query: 1463 DQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADMQDEHHVAEAIPR 1517
D + +C + P + E + + + + EA R
Sbjct: 1421 D---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGR 1477
Query: 1518 IPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGH 1572
++++ + + E LS K ++ + + + + H R SI KLDR +
Sbjct: 1478 RATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRN 1537
Query: 1573 ASSV 1576
+S+
Sbjct: 1538 TASL 1541
Score = 558 bits (1438), Expect = e-158
Identities = 274/359 (76%), Positives = 309/359 (86%), Gaps = 26/359 (7%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTR-------- 242
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLD 180
Query: 243 -----------------LGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRA 285
+GQGVP+V L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRA
Sbjct: 181 SRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 240
Query: 286 SDILSFAHKYCEEGGIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVF 345
SDIL+F HKY EEGG+INESLR+QLLVTIQKTF Y + Q+ LF I+MECMKKKEL+TVF
Sbjct: 241 SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF 300
Query: 346 RMGSEGQQDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
RMGSEG QDI++AILTALLKG N SAPDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 301 RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 358
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 1234 bits (3192), Expect = 0.0
Identities = 684/1204 (56%), Positives = 829/1204 (68%), Gaps = 102/1204 (8%)
Query: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 330 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 389
Query: 518 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMED 577
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPKRPKALKLLGMED
Sbjct: 390 KKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMED 449
Query: 578 DEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE 637
D P +G+K KK+ EEE+DID+DDP ++ F +PFHELMVWAVLMKRQKMA+F WQ GEE
Sbjct: 450 DIPLRRGRKTTKKR-EEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEE 508
Query: 638 SMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMK 697
+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLDQSYK DEQ+AMK
Sbjct: 509 AMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 568
Query: 698 LLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILL 757
LLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN GLKVI+GILL
Sbjct: 569 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 628
Query: 758 PPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDANADAG------S 799
PP+IL LEF+ DD Y + KE E+ KEKEEE+ + A G S
Sbjct: 629 PPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESS 688
Query: 800 RKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSL 859
RK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY++LV+M+ WPS
Sbjct: 689 RKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPST 748
Query: 860 QEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQ 919
QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI F +G ILRLQ
Sbjct: 749 QEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQ 808
Query: 920 NQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMS 979
+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+YFV+IMLVVLMS
Sbjct: 809 DQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMS 868
Query: 980 FGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEG 1039
FGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID PPCG+N E+G
Sbjct: 869 FGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID-------PPCGQNETREDG 921
Query: 1040 K--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 1097
K +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL
Sbjct: 922 KIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 981
Query: 1098 IMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHE 1157
IMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKLF++D+ELK++H+
Sbjct: 982 IMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKLFITDDELKKVHD 1040
Query: 1158 FEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRL 1217
FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE MK SLQTVD+RL
Sbjct: 1041 FEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRL 1100
Query: 1218 AQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSINSADGYSLYRYH 1276
AQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS NS +G +
Sbjct: 1101 AQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNT----- 1155
Query: 1277 FNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHLVPECQNSLHLSL 1328
F +E + E+T TSP R ++ SF KD + E SLH +
Sbjct: 1156 FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRAT 1215
Query: 1329 GTSTSA---------------TPDGS----------------HLAVDDLKNA-------E 1350
+ + A PD H +D L N+ E
Sbjct: 1216 SSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGE 1275
Query: 1351 ESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTN---I 1407
S P + T + + S S++ D+ +S + E N
Sbjct: 1276 PSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDS 1335
Query: 1408 EGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVNQDV---EYSSIT 1462
E + + +E +K +RY + +KS SF++S R V EY+SIT
Sbjct: 1336 EPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSIT 1395
Query: 1463 DQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADMQDEHHVAEAIPR 1517
D + +C + P + E + + + + EA R
Sbjct: 1396 D---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGR 1452
Query: 1518 IPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGH 1572
++++ + + E LS K ++ + + + + H R SI KLDR +
Sbjct: 1453 RATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRN 1512
Query: 1573 ASSV 1576
+S+
Sbjct: 1513 TASL 1516
Score = 572 bits (1474), Expect = e-162
Identities = 274/334 (82%), Positives = 309/334 (92%), Gaps = 1/334 (0%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLV 250
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR+GQGVP+V
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 251 GLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQL 310
L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRASDIL+F HKY EEGG+INESLR+QL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 311 LVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVS 370
LVTIQKTF Y + Q+ LF I+MECMKKKEL+TVFRMGSEG QDI++AILTALLKG N S
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 371 APDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
APDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 333
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 1234 bits (3192), Expect = 0.0
Identities = 684/1204 (56%), Positives = 829/1204 (68%), Gaps = 102/1204 (8%)
Query: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 483 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 542
Query: 518 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMED 577
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPKRPKALKLLGMED
Sbjct: 543 KKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMED 602
Query: 578 DEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE 637
D P +G+K KK+ EEE+DID+DDP ++ F +PFHELMVWAVLMKRQKMA+F WQ GEE
Sbjct: 603 DIPLRRGRKTTKKR-EEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEE 661
Query: 638 SMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMK 697
+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLDQSYK DEQ+AMK
Sbjct: 662 AMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 721
Query: 698 LLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILL 757
LLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN GLKVI+GILL
Sbjct: 722 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 781
Query: 758 PPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDANADAG------S 799
PP+IL LEF+ DD Y + KE E+ KEKEEE+ + A G S
Sbjct: 782 PPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESS 841
Query: 800 RKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSL 859
RK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY++LV+M+ WPS
Sbjct: 842 RKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPST 901
Query: 860 QEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQ 919
QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI F +G ILRLQ
Sbjct: 902 QEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQ 961
Query: 920 NQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMS 979
+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+YFV+IMLVVLMS
Sbjct: 962 DQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMS 1021
Query: 980 FGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEG 1039
FGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID PPCG+N E+G
Sbjct: 1022 FGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID-------PPCGQNETREDG 1074
Query: 1040 K--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 1097
K +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL
Sbjct: 1075 KIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 1134
Query: 1098 IMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHE 1157
IMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKLF++D+ELK++H+
Sbjct: 1135 IMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKLFITDDELKKVHD 1193
Query: 1158 FEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRL 1217
FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE MK SLQTVD+RL
Sbjct: 1194 FEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRL 1253
Query: 1218 AQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSINSADGYSLYRYH 1276
AQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS NS +G +
Sbjct: 1254 AQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNT----- 1308
Query: 1277 FNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHLVPECQNSLHLSL 1328
F +E + E+T TSP R ++ SF KD + E SLH +
Sbjct: 1309 FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRAT 1368
Query: 1329 GTSTSA---------------TPDGS----------------HLAVDDLKNA-------E 1350
+ + A PD H +D L N+ E
Sbjct: 1369 SSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGE 1428
Query: 1351 ESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTN---I 1407
S P + T + + S S++ D+ +S + E N
Sbjct: 1429 PSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDS 1488
Query: 1408 EGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVNQDV---EYSSIT 1462
E + + +E +K +RY + +KS SF++S R V EY+SIT
Sbjct: 1489 EPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSIT 1548
Query: 1463 DQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADMQDEHHVAEAIPR 1517
D + +C + P + E + + + + EA R
Sbjct: 1549 D---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGR 1605
Query: 1518 IPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGH 1572
++++ + + E LS K ++ + + + + H R SI KLDR +
Sbjct: 1606 RATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRN 1665
Query: 1573 ASSV 1576
+S+
Sbjct: 1666 TASL 1669
Score = 651 bits (1679), Expect = 0.0
Identities = 310/406 (76%), Positives = 360/406 (88%), Gaps = 4/406 (0%)
Query: 2 KDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQV---ETQPEKWSVAKHTQSYPTDSYGV 58
KD +RCCCG+ QH+ PS + +NE+ ++ + Q EKWS++KHTQ PTD++G
Sbjct: 82 KDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGT 141
Query: 59 LEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQ 118
+EFQGGG+SNKAMY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQ
Sbjct: 142 IEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQ 201
Query: 119 VFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKE 178
VFGKGLIKAAMTTGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+E
Sbjct: 202 VFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQE 261
Query: 179 DLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQK 238
DL+G+DV R YQTMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQK
Sbjct: 262 DLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQK 321
Query: 239 INTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEE 298
INTR+GQGVP+V L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRASDIL+F HKY EE
Sbjct: 322 INTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEE 381
Query: 299 GGIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMA 358
GG+INESLR+QLLVTIQKTF Y + Q+ LF I+MECMKKKEL+TVFRMGSEG QDI++A
Sbjct: 382 GGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLA 441
Query: 359 ILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
ILTALLKG N SAPDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 442 ILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 486
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 1225 bits (3169), Expect = 0.0
Identities = 684/1216 (56%), Positives = 829/1216 (68%), Gaps = 114/1216 (9%)
Query: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 330 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 389
Query: 518 KK------------SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPK 565
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPK
Sbjct: 390 KKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPK 449
Query: 566 RPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQ 625
RPKALKLLGMEDD P +G+K KK+ EEE+DID+DDP ++ F +PFHELMVWAVLMKRQ
Sbjct: 450 RPKALKLLGMEDDIPLRRGRKTTKKR-EEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQ 508
Query: 626 KMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLD 685
KMA+F WQ GEE+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLD
Sbjct: 509 KMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 568
Query: 686 QSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 745
QSYK DEQ+AMKLLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK
Sbjct: 569 QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 628
Query: 746 NPGLKVIMGILLPPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDA 793
N GLKVI+GILLPP+IL LEF+ DD Y + KE E+ KEKEEE+ +
Sbjct: 629 NSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMEL 688
Query: 794 NADAG------SRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNY 847
A G SRK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY
Sbjct: 689 TAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNY 748
Query: 848 VILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAI 907
++LV+M+ WPS QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI
Sbjct: 749 IVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAI 808
Query: 908 STFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDML 967
F +G ILRLQ+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+
Sbjct: 809 LLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMM 868
Query: 968 YFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEIN 1027
YFV+IMLVVLMSFGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID
Sbjct: 869 YFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID------- 921
Query: 1028 PPCGENLYDEEGK--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSI 1085
PPCG+N E+GK +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSI
Sbjct: 922 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 981
Query: 1086 SNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
SNQVWKFQRYQLIMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKL
Sbjct: 982 SNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKL 1040
Query: 1146 FLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETF 1205
F++D+ELK++H+FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE
Sbjct: 1041 FITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHS 1100
Query: 1206 MKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSI 1264
MK SLQTVD+RLAQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS
Sbjct: 1101 MKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSF 1160
Query: 1265 NSADGYSLYRYHFNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHL 1316
NS +G + F +E + E+T TSP R ++ SF KD +
Sbjct: 1161 NSQEGNT-----FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESI 1215
Query: 1317 VPECQNSLHLSLGTSTSA---------------TPDGS----------------HLAVDD 1345
E SLH + + + A PD H +D
Sbjct: 1216 FKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDP 1275
Query: 1346 LKNA-------EESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNT 1398
L N+ E S P + T + + S S++ D+ +S +
Sbjct: 1276 LDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDY 1335
Query: 1399 QLTVETTN---IEGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVN 1453
E N E + + +E +K +RY + +KS SF++S R
Sbjct: 1336 THLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFG 1395
Query: 1454 QDV---EYSSITDQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADM 1505
V EY+SITD + +C + P + E + + +
Sbjct: 1396 VPVKTAEYTSITD---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHP 1452
Query: 1506 QDEHHVAEAIPRIPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNV 1560
+ EA R ++++ + + E LS K ++ + + + + H R
Sbjct: 1453 SSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKS 1512
Query: 1561 KSIQGKLDRSGHASSV 1576
SI KLDR + +S+
Sbjct: 1513 FSISDKLDRQRNTASL 1528
Score = 572 bits (1474), Expect = e-162
Identities = 274/334 (82%), Positives = 309/334 (92%), Gaps = 1/334 (0%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLV 250
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR+GQGVP+V
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 251 GLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQL 310
L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRASDIL+F HKY EEGG+INESLR+QL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 311 LVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVS 370
LVTIQKTF Y + Q+ LF I+MECMKKKEL+TVFRMGSEG QDI++AILTALLKG N S
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 371 APDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
APDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 333
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 1207 bits (3122), Expect = 0.0
Identities = 672/1204 (55%), Positives = 818/1204 (67%), Gaps = 112/1204 (9%)
Query: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 355 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 414
Query: 518 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMED 577
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPKR
Sbjct: 415 KKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKR----------- 463
Query: 578 DEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE 637
D+ P + +K KK+EEE+DID+DDP ++ F +PFHELMVWAVLMKRQKMA+F WQ GEE
Sbjct: 464 DDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEE 523
Query: 638 SMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMK 697
+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLDQSYK DEQ+AMK
Sbjct: 524 AMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 583
Query: 698 LLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILL 757
LLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN GLKVI+GILL
Sbjct: 584 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 643
Query: 758 PPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDANADAG------S 799
PP+IL LEF+ DD Y + KE E+ KEKEEE+ + A G S
Sbjct: 644 PPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESS 703
Query: 800 RKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSL 859
RK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY++LV+M+ WPS
Sbjct: 704 RKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPST 763
Query: 860 QEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQ 919
QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI F +G ILRLQ
Sbjct: 764 QEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQ 823
Query: 920 NQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMS 979
+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+YFV+IMLVVLMS
Sbjct: 824 DQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMS 883
Query: 980 FGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEG 1039
FGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID PPCG+N E+G
Sbjct: 884 FGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID-------PPCGQNETREDG 936
Query: 1040 K--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 1097
K +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL
Sbjct: 937 KIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 996
Query: 1098 IMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHE 1157
IMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKLF++D+ELK++H+
Sbjct: 997 IMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKLFITDDELKKVHD 1055
Query: 1158 FEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRL 1217
FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE MK SLQTVD+RL
Sbjct: 1056 FEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRL 1115
Query: 1218 AQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSINSADGYSLYRYH 1276
AQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS NS +G +
Sbjct: 1116 AQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNT----- 1170
Query: 1277 FNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHLVPECQNSLHLSL 1328
F +E + E+T TSP R ++ SF KD + E SLH +
Sbjct: 1171 FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRAT 1230
Query: 1329 GTSTSA---------------TPDGS----------------HLAVDDLKNA-------E 1350
+ + A PD H +D L N+ E
Sbjct: 1231 SSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGE 1290
Query: 1351 ESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTN---I 1407
S P + T + + S S++ D+ +S + E N
Sbjct: 1291 PSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDS 1350
Query: 1408 EGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVNQDV---EYSSIT 1462
E + + +E +K +RY + +KS SF++S R V EY+SIT
Sbjct: 1351 EPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSIT 1410
Query: 1463 DQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADMQDEHHVAEAIPR 1517
D + +C + P + E + + + + EA R
Sbjct: 1411 D---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGR 1467
Query: 1518 IPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGH 1572
++++ + + E LS K ++ + + + + H R SI KLDR +
Sbjct: 1468 RATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRN 1527
Query: 1573 ASSV 1576
+S+
Sbjct: 1528 TASL 1531
Score = 558 bits (1438), Expect = e-158
Identities = 274/359 (76%), Positives = 309/359 (86%), Gaps = 26/359 (7%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTR-------- 242
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLD 180
Query: 243 -----------------LGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRA 285
+GQGVP+V L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRA
Sbjct: 181 SRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 240
Query: 286 SDILSFAHKYCEEGGIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVF 345
SDIL+F HKY EEGG+INESLR+QLLVTIQKTF Y + Q+ LF I+MECMKKKEL+TVF
Sbjct: 241 SDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVF 300
Query: 346 RMGSEGQQDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
RMGSEG QDI++AILTALLKG N SAPDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 301 RMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 358
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 1207 bits (3122), Expect = 0.0
Identities = 672/1204 (55%), Positives = 818/1204 (67%), Gaps = 112/1204 (9%)
Query: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 330 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 389
Query: 518 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMED 577
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPKR
Sbjct: 390 KKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKR----------- 438
Query: 578 DEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE 637
D+ P + +K KK+EEE+DID+DDP ++ F +PFHELMVWAVLMKRQKMA+F WQ GEE
Sbjct: 439 DDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEE 498
Query: 638 SMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMK 697
+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLDQSYK DEQ+AMK
Sbjct: 499 AMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 558
Query: 698 LLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILL 757
LLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKN GLKVI+GILL
Sbjct: 559 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 618
Query: 758 PPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDANADAG------S 799
PP+IL LEF+ DD Y + KE E+ KEKEEE+ + A G S
Sbjct: 619 PPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESS 678
Query: 800 RKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSL 859
RK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY++LV+M+ WPS
Sbjct: 679 RKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPST 738
Query: 860 QEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQ 919
QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI F +G ILRLQ
Sbjct: 739 QEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQ 798
Query: 920 NQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMS 979
+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+YFV+IMLVVLMS
Sbjct: 799 DQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMS 858
Query: 980 FGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEG 1039
FGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID PPCG+N E+G
Sbjct: 859 FGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID-------PPCGQNETREDG 911
Query: 1040 K--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 1097
K +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL
Sbjct: 912 KIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL 971
Query: 1098 IMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHE 1157
IMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKLF++D+ELK++H+
Sbjct: 972 IMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKLFITDDELKKVHD 1030
Query: 1158 FEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRL 1217
FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE MK SLQTVD+RL
Sbjct: 1031 FEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRL 1090
Query: 1218 AQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSINSADGYSLYRYH 1276
AQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS NS +G +
Sbjct: 1091 AQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNT----- 1145
Query: 1277 FNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHLVPECQNSLHLSL 1328
F +E + E+T TSP R ++ SF KD + E SLH +
Sbjct: 1146 FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRAT 1205
Query: 1329 GTSTSA---------------TPDGS----------------HLAVDDLKNA-------E 1350
+ + A PD H +D L N+ E
Sbjct: 1206 SSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGE 1265
Query: 1351 ESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTN---I 1407
S P + T + + S S++ D+ +S + E N
Sbjct: 1266 PSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDS 1325
Query: 1408 EGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVNQDV---EYSSIT 1462
E + + +E +K +RY + +KS SF++S R V EY+SIT
Sbjct: 1326 EPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSIT 1385
Query: 1463 DQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADMQDEHHVAEAIPR 1517
D + +C + P + E + + + + EA R
Sbjct: 1386 D---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGR 1442
Query: 1518 IPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGH 1572
++++ + + E LS K ++ + + + + H R SI KLDR +
Sbjct: 1443 RATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRN 1502
Query: 1573 ASSV 1576
+S+
Sbjct: 1503 TASL 1506
Score = 572 bits (1474), Expect = e-162
Identities = 274/334 (82%), Positives = 309/334 (92%), Gaps = 1/334 (0%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLV 250
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR+GQGVP+V
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 251 GLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQL 310
L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRASDIL+F HKY EEGG+INESLR+QL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 311 LVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVS 370
LVTIQKTF Y + Q+ LF I+MECMKKKEL+TVFRMGSEG QDI++AILTALLKG N S
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 371 APDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
APDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 333
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 1198 bits (3099), Expect = 0.0
Identities = 672/1216 (55%), Positives = 818/1216 (67%), Gaps = 124/1216 (10%)
Query: 458 VNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 517
V +LEQAMLDALVLDRVDFVKLLIENGV+M FLTI RLEELYNTR GP NTL+ LVRDV
Sbjct: 330 VGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV 389
Query: 518 KK------------SNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPK 565
KK NLPPDY ISLIDIGLV+EYLMGGAYRCNYTRK FRTLY+NLFGPK
Sbjct: 390 KKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPK 449
Query: 566 RPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQ 625
R D+ P + +K KK+EEE+DID+DDP ++ F +PFHELMVWAVLMKRQ
Sbjct: 450 R-----------DDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQ 498
Query: 626 KMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLD 685
KMA+F WQ GEE+MAKALVACKL KAMAHE+SE+D+VDDISQ+L++NS+DFGQLA+ELLD
Sbjct: 499 KMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 558
Query: 686 QSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 745
QSYK DEQ+AMKLLTYELKNWSN+TCL+LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK
Sbjct: 559 QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 618
Query: 746 NPGLKVIMGILLPPTILFLEFRTYDDFSYQTS--------KENEDG----KEKEEENTDA 793
N GLKVI+GILLPP+IL LEF+ DD Y + KE E+ KEKEEE+ +
Sbjct: 619 NSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMEL 678
Query: 794 NADAG------SRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNY 847
A G SRK DEE K R IP+G KI EFYNAPIVKFWFYT++Y+GYL+LFNY
Sbjct: 679 TAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNY 738
Query: 848 VILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAI 907
++LV+M+ WPS QEWIVISYI +L +EK+REILMSEPGKL QK+KVWLQEYWN+TDL+AI
Sbjct: 739 IVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAI 798
Query: 908 STFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDML 967
F +G ILRLQ+QP+ GRVIYCV+II+WYIR+LDIFGVNKYLGPYVMMIGKMMIDM+
Sbjct: 799 LLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMM 858
Query: 968 YFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEIN 1027
YFV+IMLVVLMSFGVARQAIL P E+PSWKLA+NIFYMPYWMIYGEVFADQID
Sbjct: 859 YFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQID------- 911
Query: 1028 PPCGENLYDEEGK--RLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSI 1085
PPCG+N E+GK +LPPC GAW+ PA+MACYLLVANILLVNLLIAVFNNTFFEVKSI
Sbjct: 912 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 971
Query: 1086 SNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
SNQVWKFQRYQLIMTFH+RPVLPPP+II SH+ +I L R R K E D +ERD GLKL
Sbjct: 972 SNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWR-KHESDPDERDYGLKL 1030
Query: 1146 FLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETF 1205
F++D+ELK++H+FEEQC++E+FREK+D SS+DERIRVTSERVENMSMRLEE+NERE
Sbjct: 1031 FITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHS 1090
Query: 1206 MKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSEC-EATYLLRQSSI 1264
MK SLQTVD+RLAQLE+L RM ALE L G++R++ + RSR SS+C +A Y++RQSS
Sbjct: 1091 MKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSF 1150
Query: 1265 NSADGYSLYRYHFNGEELL---FEDTSLSTSPGTGVRKKTCSFRIKEEKD-----VKTHL 1316
NS +G + F +E + E+T TSP R ++ SF KD +
Sbjct: 1151 NSQEGNT-----FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESI 1205
Query: 1317 VPECQNSLHLSLGTSTSA---------------TPDGS----------------HLAVDD 1345
E SLH + + + A PD H +D
Sbjct: 1206 FKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDP 1265
Query: 1346 LKNA-------EESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNT 1398
L N+ E S P + T + + S S++ D+ +S +
Sbjct: 1266 LDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDY 1325
Query: 1399 QLTVETTN---IEGTISYPLEETKITRYFPDE--TINACKTMKSRSFVYSRGRKLVGGVN 1453
E N E + + +E +K +RY + +KS SF++S R
Sbjct: 1326 THLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFG 1385
Query: 1454 QDV---EYSSITDQQLTTEWQCQVQKITRSHSTDIP-----YIVSEAAVQAEHKEQFADM 1505
V EY+SITD + +C + P + E + + +
Sbjct: 1386 VPVKTAEYTSITD---CIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHP 1442
Query: 1506 QDEHHVAEAIPRIPRLSLTITDRNGMENLLS-----VKPDQTLGFPSLRSKSLHGHPRNV 1560
+ EA R ++++ + + E LS K ++ + + + + H R
Sbjct: 1443 SSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKS 1502
Query: 1561 KSIQGKLDRSGHASSV 1576
SI KLDR + +S+
Sbjct: 1503 FSISDKLDRQRNTASL 1518
Score = 572 bits (1474), Expect = e-162
Identities = 274/334 (82%), Positives = 309/334 (92%), Gaps = 1/334 (0%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLV 250
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR+GQGVP+V
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 251 GLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQL 310
L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRASDIL+F HKY EEGG+INESLR+QL
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQL 240
Query: 311 LVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVS 370
LVTIQKTF Y + Q+ LF I+MECMKKKEL+TVFRMGSEG QDI++AILTALLKG N S
Sbjct: 241 LVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANAS 300
Query: 371 APDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL 404
APDQLSLALAWNRVDIARSQIF++G W P+GSL
Sbjct: 301 APDQLSLALAWNRVDIARSQIFIYGQQW-PVGSL 333
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 1169 bits (3025), Expect = 0.0
Identities = 622/1290 (48%), Positives = 856/1290 (66%), Gaps = 80/1290 (6%)
Query: 6 RCCCGQFTNQHIPPLPSATPSKNEEESKQVETQP-EKWSVAKHTQSYPTDSYGVLEFQGG 64
RC CG+ QH S ++ + Q E+WSV KHT+ PTD+YGV+ FQGG
Sbjct: 41 RCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGG 100
Query: 65 GYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGL 124
+S +A Y+R+SYDTKP+ +L L++K+WQ+ELPKL+ISVHGG+Q FE+ P++KQ+ GKGL
Sbjct: 101 SHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGL 160
Query: 125 IKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKD 184
IKAA+TTGAWI TGGV+TGV HVGDALK+H+S+S ++C IGIAPWG++EN+ DLVG+D
Sbjct: 161 IKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRD 220
Query: 185 VTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLG 244
V YQT+ NPLSKL+VLNN H+HFIL D+GT+GKYGAEV+LRR LEK I+ Q+I+ R+G
Sbjct: 221 VVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIG 280
Query: 245 QGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINE 304
QGVP+V L+ EGGPNV+ VLEYLQE PP+PVV+C+G+GRA+D+L++ HK EEGG + +
Sbjct: 281 QGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPD 340
Query: 305 SLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALL 364
+ ++ TI+KTFN+ + ++ LF +MECMK+KEL+TVF +GS+ QDI++AILTALL
Sbjct: 341 AAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALL 400
Query: 365 KGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPPMATT 424
KGTN SA DQL L LAW+RVDIA++ +FV+G W +GSL
Sbjct: 401 KGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQW-LVGSLEQAMLDALVMDRVAFVKLLI 459
Query: 425 KGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIE-- 482
+ G K +++E + P L + V ++Q L + + L+IE
Sbjct: 460 ENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYL 519
Query: 483 NGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMG 542
G + T R +YN+ LG N S+ P S G
Sbjct: 520 MGGTYRCTYTRKRFRLIYNS-LGGNNRR----SGRNTSSSTPQLRKSHESFG-------- 566
Query: 543 GAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDD 602
N K + +N+ +P K+ D +GKKK+ K +EI +D+DD
Sbjct: 567 -----NRADKKEKMRHNHFIKTAQPYRPKI-----DTVMEEGKKKRTK---DEI-VDIDD 612
Query: 603 PAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLV 662
P RF YP +EL++WA LMKRQ MA FLWQ GEESMAKALVACK+Y++MA+E+ +SDLV
Sbjct: 613 PETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLV 672
Query: 663 DDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRD 722
DD S++L S DFGQLA+ELL+QS++ DE +AMKLLTYELKNWSNSTCLKLAV+++ R
Sbjct: 673 DDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRP 732
Query: 723 FIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENED 782
F+AHTC+QMLL+DMWMGRL MRKN KVI+ IL+PP IL LE++T + S+ +++D
Sbjct: 733 FVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSH--IPQSQD 790
Query: 783 GKEKEEENTDANAD----------------AGSRKGDEENE-HKKQRSIPIGTKICEFYN 825
+ ++++ N S +G E E K + +PI K FY+
Sbjct: 791 AHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYH 850
Query: 826 APIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPG 885
APIVKFWF T++YLG+L+L+ +V+LV+M+ PS+QEWIVI+YI + A+EK+REI MSE G
Sbjct: 851 APIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAG 910
Query: 886 KLSQKIKVWLQEYWNITDLVAISTFMIGAILRL----------QNQPYMGYGRVIYCVDI 935
K++QKIKVW +Y+NI+D +AI +F IG LR N ++ GR+IYC++I
Sbjct: 911 KVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA-GRLIYCLNI 969
Query: 936 IFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPS 995
IFWY+R+LD VN+ GPYVMMIGKM+ +M Y VVIM +VL+SFGV R+AIL+P E PS
Sbjct: 970 IFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPS 1029
Query: 996 WKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPAL 1055
W LA++I + PYWMI+GEV+A +ID+ A + P C PG WLTP L
Sbjct: 1030 WTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIP-------------QICGPGTWLTPFL 1076
Query: 1056 MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILS 1115
A YL V I++VNLLIA FNN + +VK+ISN VWK+QRY IM +H++PVLPPP+IILS
Sbjct: 1077 QAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILS 1136
Query: 1116 HIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQ 1175
HI + + R +K + D G KLFL++E+ K+LH+FEEQCV+ +F EK+D+
Sbjct: 1137 HIVSLFCCICKRRKKDKTSD------GPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFH 1190
Query: 1176 SSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENLA 1235
S S+ERIRVT ERVE M ++++E+ +R ++K SLQ++D ++ L++LS V+ L+ L
Sbjct: 1191 SGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLT 1250
Query: 1236 GIDRSDLIQARSRASSECEATYLLRQSSIN 1265
S+ + + + E + L Q+ I+
Sbjct: 1251 AQKASEASKVHNEITRELSISKHLAQNLID 1280
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 831 bits (2146), Expect = 0.0
Identities = 429/831 (51%), Positives = 582/831 (70%), Gaps = 56/831 (6%)
Query: 459 NALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTL-HLLVRDV 517
+ALEQAM DALV+DRVDFVKLLIE GVN+ FLTIPRLEELYNT+ GP NTL H LV+DV
Sbjct: 438 DALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDV 497
Query: 518 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLF----------GPKRP 567
K+ L Y I+LIDIGLV+EYL+G AYR NYTRK+FR LYNNL+ G +
Sbjct: 498 KQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNE 557
Query: 568 KALKLLGME--DDEPPAKGKKK-----KKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAV 620
A L + P K K+K K +KK +E ++ DDP + F YP+++L+VWAV
Sbjct: 558 SAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVS-DDPESTGFLYPYNDLLVWAV 616
Query: 621 LMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLA 680
LMKRQKMA+F WQ GEE+ KA++AC LY+AMAHE+ ES +VDD S++L N SK FGQLA
Sbjct: 617 LMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLA 676
Query: 681 LELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGR 740
L+LL++++K +E++AM LLTYEL+NWSNSTCLKLAV+ R F++HTC+QMLLTDMWMGR
Sbjct: 677 LDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGR 736
Query: 741 LRMRKNPGLKVIMGILLPPTILFLEFRTYDD-----------FSYQTSKENEDGKEKEEE 789
L+MRKN LK+I+ I+LPPTIL LEF++ + F + S +N ++
Sbjct: 737 LKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESAS 796
Query: 790 NTDANADAGSRKGDEENEH----KKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLF 845
+ + + G + +EN+H + +P K+ EFY+APIVKFWFYT++YL +L+LF
Sbjct: 797 VKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLF 856
Query: 846 NYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLV 905
Y +LV M PS+QEW+V YI + A+E +REI +SEPGK +QK+KVW+ EYWN+T+ V
Sbjct: 857 TYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETV 916
Query: 906 AISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMID 965
AI F G +LR + P+ GR+IYC+DIIFW+ R+LD F VN++ GPYV MI KM +
Sbjct: 917 AIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTAN 976
Query: 966 MLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAME 1025
M Y V+IM +VL+SFGVAR+AIL P+E PSW LAR+I + PYWMIYGEV+A +ID+ + +
Sbjct: 977 MFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
Query: 1026 INPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSI 1085
P C PG++LTP L A YL V I++VNLLIA FNN + +++SI
Sbjct: 1037 -----------------PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESI 1079
Query: 1086 SNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
SN +WK+ RY+ IMT+H++P LPPP+I+LSH+ +++ RL C + DQEE D GLKL
Sbjct: 1080 SNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRL---CCHRAPHDQEEGDVGLKL 1136
Query: 1146 FLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETF 1205
+LS E+LK+LH+FEEQCV+++F EK ++ S +ERIRVTSERV M +L+E+NE+ +F
Sbjct: 1137 YLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSF 1196
Query: 1206 MKTSLQTVDLRLAQLEELSNRMVNALENLAGID--RSDLIQARSRASSECE 1254
+K SL ++D ++ L++LS V+ L+ L+ +D + D R S C+
Sbjct: 1197 IKDSLLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCK 1247
Score = 452 bits (1162), Expect = e-126
Identities = 215/395 (54%), Positives = 296/395 (74%), Gaps = 8/395 (2%)
Query: 6 RCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGG 65
RC CG+ H S T S + + + E+WSV KHT PTD++G + FQ G
Sbjct: 51 RCYCGRLIGDHAGIDYSWTISAAKGK------ESEQWSVEKHTTKSPTDTFGTINFQDGE 104
Query: 66 YSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLI 125
+++ A YIR SYDTK D LLHLM+K+W++ELPKL+ISVHGG+QNF M K K++F +GL+
Sbjct: 105 HTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLV 164
Query: 126 KAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDV 185
KAA TTGAWI T G++TGV HVGDALK HSS S ++ +GI PWG++EN+ DL+GKDV
Sbjct: 165 KAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDV 224
Query: 186 TRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQ 245
+YQT+ NPLSKL+ LN+ H+HFIL+D+GT+GKYG E+KLRR LEK++SLQKI+ R Q
Sbjct: 225 VCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQ 284
Query: 246 GVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINES 305
GVP+VGLVVEGGPNV+ V E ++++ PVV+C+G+GRA+D+L+F HK+ + G++
Sbjct: 285 GVPVVGLVVEGGPNVILSVWETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQ 342
Query: 306 LREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLK 365
++E+++ IQ TFN++ QS LF I+MECM ++ +T+F SE QQD+++AILTALLK
Sbjct: 343 VKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLK 402
Query: 366 GTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPP 400
GTN+SA +QL+LA+AW+RVDIA+ I ++ HW P
Sbjct: 403 GTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKP 437
>gi|45935368 transient receptor potential cation channel, subfamily
M, member 3 isoform h [Homo sapiens]
Length = 230
Score = 411 bits (1057), Expect = e-114
Identities = 193/230 (83%), Positives = 217/230 (94%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLV 250
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR+GQGVP+V
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVV 180
Query: 251 GLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGG 300
L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRASDIL+F HKY EEGG
Sbjct: 181 ALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGG 230
>gi|55953096 transient receptor potential cation channel, subfamily
M, member 3 isoform c [Homo sapiens]
Length = 255
Score = 397 bits (1021), Expect = e-110
Identities = 193/255 (75%), Positives = 217/255 (85%), Gaps = 25/255 (9%)
Query: 71 MYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMT 130
MY+RVS+DTKPD LLHLM K+WQLELPKLLISVHGGLQNFE+QPKLKQVFGKGLIKAAMT
Sbjct: 1 MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMT 60
Query: 131 TGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQ 190
TGAWIFTGGV+TGVI HVGDALKDH+SKSRG++C IGIAPWGIVEN+EDL+G+DV R YQ
Sbjct: 61 TGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQ 120
Query: 191 TMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTR-------- 242
TMSNP+SKL+VLN+ H+HFILADNGT GKYGAEVKLRR LEKHISLQKINTR
Sbjct: 121 TMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLD 180
Query: 243 -----------------LGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRA 285
+GQGVP+V L+VEGGPNV+SIVLEYL++ PP+PVV+CDGSGRA
Sbjct: 181 SRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRA 240
Query: 286 SDILSFAHKYCEEGG 300
SDIL+F HKY EEGG
Sbjct: 241 SDILAFGHKYSEEGG 255
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 316 bits (809), Expect = 1e-85
Identities = 230/796 (28%), Positives = 393/796 (49%), Gaps = 84/796 (10%)
Query: 445 EETDPRKIELLN----WVNA-LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEEL 499
+ D K E+ N W + LE+ M+DALV ++ +FV+L ++NG ++ FLT RL+EL
Sbjct: 359 DRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQEL 418
Query: 500 YNTRLGPPNTLHLLVRDVKKSNL----------------PPDYHISLIDIGLVLEYLMGG 543
Y + LL R +++ L PP + SL ++ VL+ +
Sbjct: 419 YRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQD 476
Query: 544 AYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDP 603
A R + RP D KG K+ ++ +D++
Sbjct: 477 ACR-------------GFYQDGRPG--------DRRRAEKGPAKRPTGQKWLLDLN---- 511
Query: 604 AVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVD 663
+ + P+ +L +WAVL R +MA + W G+E +A AL ACK+ K M+H +E++
Sbjct: 512 --QKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR 569
Query: 664 DISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDF 723
+ + +LAL+L + Y + E A LL + WS +TCL LA A + F
Sbjct: 570 ATRE------AKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAF 623
Query: 724 IAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENEDG 783
AH Q LT +W G M + ++G L P +++ T+ + + ED
Sbjct: 624 FAHDGVQAFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEA-PLRTGLEDL 680
Query: 784 KEKEEENTDANADAGSRKGDEE-------NEHKKQRSIPIGTKICEFYNAPIVKFWFYTI 836
++ + +T+ + G + EE + R++ + T+ +F+ AP+ F +
Sbjct: 681 QDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVV 740
Query: 837 SYLGYLLLFNYVILVRM---DGWPSLQEWIVISYIVSLALEKIRE-ILMSEPGKLSQKIK 892
Y +L LF YV+LV PS E + ++ +L LE+IR+ E L +K
Sbjct: 741 MYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFT 800
Query: 893 VWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYL 952
+++ + WN D+VAI F++G R+ + GR + +D + + +R++ IF ++K L
Sbjct: 801 LYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQL 859
Query: 953 GPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYG 1012
GP ++++ +MM D+ +F+ + V L+++GV QA+LHP + + R + Y PY I+G
Sbjct: 860 GPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFG 919
Query: 1013 EVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLI 1072
++ D+ID E C + E P + WL L+ +LLV N+LL+NLLI
Sbjct: 920 QIPLDEID----EARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLI 975
Query: 1073 AVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKR 1132
A+F+ TF V+ ++ WKFQRY LI+ +H+RP L PP I+LSH+ + + R+ +K+
Sbjct: 976 AMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRV---FKKEA 1032
Query: 1133 EGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREK-EDEQQSSSDERIRVTSERVEN 1191
E +E +R L + L + E +E+F K E ++ S E +R T+ RV+
Sbjct: 1033 EHKREHLERDL-----PDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDF 1087
Query: 1192 MSMRLEEINERETFMK 1207
++ L + E+E +K
Sbjct: 1088 IAKYLGGLREQEKRIK 1103
Score = 153 bits (387), Expect = 1e-36
Identities = 115/363 (31%), Positives = 182/363 (50%), Gaps = 45/363 (12%)
Query: 63 GGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGK 122
GG + ++RV P L L++ +W L P L++S+ G Q F M+ L+ V K
Sbjct: 31 GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRK 90
Query: 123 GLIKAAMTTGAWIFTGGVSTGVISHVGDALKDH---SSKSRGRVCAIGIAPWGIVENKED 179
GL+KAA +TGAWI T + G+ HVG A++DH S+ ++ RV A+G+A G V ++
Sbjct: 91 GLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRI 150
Query: 180 L--VGKDVTRVY-QTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISL 236
L +D Y + L L+++ +HFIL + G GK +LR LEKHIS
Sbjct: 151 LEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISE 210
Query: 237 QKINTRLGQG------VPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILS 290
Q R G G +P++ L+V G PN + + +++ P +++ GSG +D+L+
Sbjct: 211 Q----RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA 264
Query: 291 FAHKYCEEGGIINESLREQLLV--TIQKTFNYNKAQSHQLFAIIMECMK-------KKEL 341
++N+ LLV +K F H + I+ K + L
Sbjct: 265 ---------ALVNQ---PHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHL 312
Query: 342 VTVFRMGSEGQQDIEMAILTALLKGTNVSAP------DQLSLALAWNRVDIARSQIFVFG 395
+TV+ EG ++++ IL AL+K + D+L LA+AW+RVDIA+S+IF
Sbjct: 313 LTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGD 372
Query: 396 PHW 398
W
Sbjct: 373 VEW 375
>gi|21314671 transient receptor potential cation channel, subfamily M,
member 4 [Homo sapiens]
Length = 1214
Score = 313 bits (802), Expect = 9e-85
Identities = 234/790 (29%), Positives = 387/790 (48%), Gaps = 84/790 (10%)
Query: 461 LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKS 520
LE +++DAL+ DR +FV+LLI +G+++ HFLT RL +LY+ P N+L + D
Sbjct: 425 LEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASH 482
Query: 521 NLPPDYHISLIDIGLVLEYLMGGA--YRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDD 578
+ G L GGA R R L + P+ P G D
Sbjct: 483 SA-----------GTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPS-----GGAWD 526
Query: 579 EPPAKGKKKK----KKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQR 634
P +G + K + +D Q P+ +L++WA+L+ R +MA++ W+
Sbjct: 527 PHPGQGFGESMYLLSDKATSPLSLDA-----GLGQAPWSDLLLWALLLNRAQMAMYFWEM 581
Query: 635 GEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQI 694
G +++ AL AC L + MA +++ + ++ D K F + ++L + Y+ E
Sbjct: 582 GSNAVSSALGACLLLRVMARLEPDAE---EAARRKDLAFK-FEGMGVDLFGECYRSSEVR 637
Query: 695 AMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMG 754
A +LL W ++TCL+LA+ A R F A Q LLT W G + P +++
Sbjct: 638 AARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMAST-TPIWALVLA 696
Query: 755 ILLPPTIL--FLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQR 812
PP I + FR E E +E+ E + D+ + G + K
Sbjct: 697 FFCPPLIYTRLITFR---------KSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPL 747
Query: 813 SIP------------IGTKIC-----EFYNAPIVKFWFYTISYLGYLLLFNYVILVRMD- 854
+P G + C F+ AP+ F +SYL +LLLF+ V+LV
Sbjct: 748 GVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQP 807
Query: 855 GWPSLQEWIVISYIVSLALEKIREILMSEPGKL------------SQKIKVWLQEYWNIT 902
P E ++ + +L E++R+ L G L SQ+++++L + WN
Sbjct: 808 APPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQC 867
Query: 903 DLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKM 962
DLVA++ F++G RL Y GR + C+D + + +R+L IF VNK LGP ++++ KM
Sbjct: 868 DLVALTCFLLGVGCRLTPGLYH-LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKM 926
Query: 963 MIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLY 1022
M D+ +F+ + V L+++GVA + +L P + + R +FY PY I+G++ + +D+
Sbjct: 927 MKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVA 986
Query: 1023 AMEINPPCGENLY--DEEGKRLPPCIP--GAWLTPALMACYLLVANILLVNLLIAVFNNT 1078
ME + E + G + C+ WL L+ +LLVANILLVNLLIA+F+ T
Sbjct: 987 LMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYT 1046
Query: 1079 FFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEE 1138
F +V+ S+ WK QRY+LI FH RP L PP I++SH+ +++ +L CR+ R
Sbjct: 1047 FGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQL---CRRPRSPQPSS 1103
Query: 1139 RD-RGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLE 1197
+++LS E ++L +E + + +++ S ER++ TS++V+ +L
Sbjct: 1104 PALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLG 1163
Query: 1198 EINERETFMK 1207
I E E +K
Sbjct: 1164 HIREYEQRLK 1173
Score = 186 bits (471), Expect = 2e-46
Identities = 123/370 (33%), Positives = 200/370 (54%), Gaps = 23/370 (6%)
Query: 42 WSVAKHTQSYPTDSYGVLEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLI 101
W HT PTD+YG L+F G G + + ++R+S T P ++ L+ + W P L++
Sbjct: 61 WDSDAHTTEKPTDAYGELDFTGAGRKH-SNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVV 119
Query: 102 SVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRG 161
SV GG +Q L+ + +GL++AA +TGAWI TGG+ TG+ HVG A++DH S G
Sbjct: 120 SVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTG 179
Query: 162 --RVCAIGIAPWGIVENKEDLVGK--DVTRVYQTMSNPLSKLSV-LNNSHTHFILADNGT 216
+V A+G+APWG+V N++ L+ Y+ +P + L+ +++ F L D+GT
Sbjct: 180 GTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGT 239
Query: 217 LGKYGAEVKLRRLLEKHISLQKINT-RLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIP 275
G G E + R LE +IS QK G +P++ L+++G +++ + Q + +P
Sbjct: 240 HGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQ--LP 297
Query: 276 VVICDGSGRASDILSFAHKYC---EEGGIINESLREQLLVTIQKTFNYNKAQSHQLFAII 332
++ GSG A+D L+ + GG R+++ + F + K L A +
Sbjct: 298 CLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRI-----RRF-FPKGDLEVLQAQV 351
Query: 333 MECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVSAP----DQLSLALAWNRVDIAR 388
M +KEL+TV+ +G ++ E +L AL+K S D+L LA+AWNRVDIA+
Sbjct: 352 ERIMTRKELLTVY-SSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQ 410
Query: 389 SQIFVFGPHW 398
S++F W
Sbjct: 411 SELFRGDIQW 420
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 297 bits (760), Expect = 6e-80
Identities = 237/853 (27%), Positives = 408/853 (47%), Gaps = 100/853 (11%)
Query: 461 LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLH-----LLVR 515
L M AL+ ++ +FVKL +ENGV ++ F+T L LY L P H +LV
Sbjct: 484 LHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYEN-LDPSCLFHSKLQKVLVE 542
Query: 516 DVKKSNLPPDY-HISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLG 574
D ++ P + + + VL L+G + Y R L K L + G
Sbjct: 543 DPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVK-LNVQG 601
Query: 575 MEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQR 634
+ + K+ + +D P +L++WA++ R+++A +W +
Sbjct: 602 VS--------LRSLYKRSSGHVTFTMD---------PIRDLLIWAIVQNRRELAGIIWAQ 644
Query: 635 GEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQI 694
++ +A AL K+ K ++ E ++D S+++ ++++ A+ + + Y+ DE+
Sbjct: 645 SQDCIAAALACSKILKELSKEEEDTDS----SEEMLALAEEYEHRAIGVFTECYRKDEER 700
Query: 695 AMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMG 754
A KLLT + W +TCL+LA+ AK F++H Q LT +W G+L + N +V +
Sbjct: 701 AQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV-DNGLWRVTLC 759
Query: 755 ILLPPTIL--FLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQR 812
+L P +L + FR E+ D A +
Sbjct: 760 MLAFPLLLTGLISFR-------------------EKRLQDVGTPAARARA---------- 790
Query: 813 SIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLA 872
F+ AP+V F +SY +L LF YV++V PS E + ++ SL
Sbjct: 791 ----------FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLV 840
Query: 873 LEKIREILMSEPGK--LSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGY-GRV 929
E++R+ L +P + L +K ++ ++WN D+ AI F+ G RL P Y GRV
Sbjct: 841 CEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLI--PATLYPGRV 897
Query: 930 IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAIL- 988
I +D I + +R++ IF ++K LGP ++++ +MM D+ +F+ ++ V ++SFGVA+QAIL
Sbjct: 898 ILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILI 957
Query: 989 HPEEKPSWKLARNIFYMPYWMIYGEV--FADQIDLYAMEINP----PCGENLYDEEGKRL 1042
H E + W L R Y Y I+G++ + D ++ +P P + + +
Sbjct: 958 HNERRVDW-LFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQ 1016
Query: 1043 PPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFH 1102
P P WLT L+ YLL NILL+NLLIA+FN TF +V+ ++Q+WKFQR+ LI +H
Sbjct: 1017 RPAFP-EWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYH 1075
Query: 1103 DRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQC 1162
RP PPP I+LSH+ + I R+ + KR + LK L E L +E
Sbjct: 1076 GRPAAPPPFILLSHLQLFIKRVVLKTPAKRH-------KQLKNKLEKNEEAALLSWEIYL 1128
Query: 1163 VQEHFREKEDEQQSSSDERIRVTSERVENMSMRLE-EINERETFMKTSLQTVDLRLAQLE 1221
+ + + ++ +Q+ +++I S +V+ M L+ + +R M+ L +++ ++AQ
Sbjct: 1129 KENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTA 1188
Query: 1222 ELSNRMVNALENLAGIDRSDL-IQARSRASSECEATYLLRQSSINSADGYSLYRYHFNGE 1280
+ +V L +D+ A +A+ E +A R+ + D YH N
Sbjct: 1189 RALHWIVRTLRASGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDS-----YHVNAR 1243
Query: 1281 ELLFEDTSLSTSP 1293
LL+ + ++ P
Sbjct: 1244 HLLYPNCPVTRFP 1256
Score = 258 bits (659), Expect = 3e-68
Identities = 156/408 (38%), Positives = 230/408 (56%), Gaps = 29/408 (7%)
Query: 7 CCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGGY 66
C CG QH+ EE +K Q +W KH Q PTD++G + F G
Sbjct: 89 CQCGYTHEQHL-----------EEATKPHTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQ 137
Query: 67 SNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIK 126
K Y+RVS DT + HLM + W L++P LLISV GG +NF M+P+LK +F +GL+K
Sbjct: 138 KVKK-YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVK 196
Query: 127 AAMTTGAWIFTGGVSTGVISHVGDALKD---HSSKSRGRVCAIGIAPWGIVENKEDLVGK 183
A TTGAWI TGG TGV+ VG+A++D SS G + IG+A WG V +E L+
Sbjct: 197 VAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHP 256
Query: 184 --DVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQ-KIN 240
Y + L+ L+++H+HFIL D+GT G+YG E+ LR LEK IS Q K
Sbjct: 257 TGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKER 316
Query: 241 TRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGG 300
+ +P+V +V+EGGP + + P V+ +GSGR +D+++
Sbjct: 317 GGVAIKIPIVCVVLEGGPGTLHTIDNATTN--GTPCVVVEGSGRVADVIAQVAN-LPVSD 373
Query: 301 IINESLREQLLVTIQKTF-NYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAI 359
I ++++L V Q+ F + +++ + I + +++++L+TVFR G +GQQD+++AI
Sbjct: 374 ITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAI 433
Query: 360 LTALLKGT-------NVSAPDQLSLALAWNRVDIARSQIFVFGPHWPP 400
L ALLK + + + QL LA+AWNRVDIARS+IF+ W P
Sbjct: 434 LQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKP 481
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 253 bits (647), Expect = 8e-67
Identities = 190/690 (27%), Positives = 331/690 (47%), Gaps = 120/690 (17%)
Query: 457 WVNA-LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVR 515
W +A L++ M AL+ DR FV+L +ENG+N++ FLT L EL++ +TL
Sbjct: 453 WESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHF---STLVYRNL 509
Query: 516 DVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGM 575
+ K++ Y+ +L+ L NFR
Sbjct: 510 QIAKNS----YNDALLTFVWKLV-------------ANFR-------------------- 532
Query: 576 EDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRG 635
+G +K+ + +E+DI++ D + ++P L +WA+L +++++ +W++
Sbjct: 533 -------RGFRKEDRNGRDEMDIELHDVSPIT-RHPLQALFIWAILQNKKELSKVIWEQT 584
Query: 636 EESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIA 695
AL A KL K +A ++ + + S++L N ++ A+EL + Y DE +A
Sbjct: 585 RGCTLAALGASKLLKTLAKVKNDINAAGE-SEELAN---EYETRAVELFTECYSSDEDLA 640
Query: 696 MKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGI 755
+LL Y + W S CL+LAV A + FIA Q L+ W G + R K+I+ +
Sbjct: 641 EQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEIS-RDTKNWKIILCL 699
Query: 756 LLPPTIL--FLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRS 813
+ P + F+ FR K+ D +HKK
Sbjct: 700 FIIPLVGCGFVSFR----------KKPVD------------------------KHKKLLW 725
Query: 814 IPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLAL 873
+ F+ +P V F + + Y+ +LLLF YV+L+ P E ++ S + L
Sbjct: 726 YYVA-----FFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC 780
Query: 874 EKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQ--NQPYMGYGRVIY 931
+++R+ ++ + + WN+ D + + F+ G + RL N+ + GRVI+
Sbjct: 781 DEVRQWYVNGVN--------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIF 832
Query: 932 CVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPE 991
C+D I + +R++ IF V++ LGP ++M+ +M+ID+ +F+ + V +++FGVARQ IL
Sbjct: 833 CLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQN 892
Query: 992 EKPSWKLARNIFYMPYWMIYGEVFAD---------QIDLYAMEINPPCGENLYDEEGKRL 1042
E+ + R++ Y PY ++G+V +D E P C E L + R
Sbjct: 893 EQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVE-LDEHNLPRF 951
Query: 1043 PPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFH 1102
P W+T L+ Y+L NILLVNLL+A+F T V+ ++QVWKFQRY L+ +
Sbjct: 952 P-----EWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYC 1006
Query: 1103 DRPVLPPPMIILSHIYIIIMRLSGRCRKKR 1132
R +P P I+ ++ Y+++ + C K++
Sbjct: 1007 SRLNIPFPFIVFAYFYMVVKKCFKCCCKEK 1036
Score = 211 bits (537), Expect = 5e-54
Identities = 131/409 (32%), Positives = 223/409 (54%), Gaps = 36/409 (8%)
Query: 5 NRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGG 64
N C CG +QH+ E Q+ Q EKW+ KHT+ +PTD++G ++F+
Sbjct: 66 NVCKCGYAQSQHM-------------EGTQIN-QSEKWNYKKHTKEFPTDAFGDIQFETL 111
Query: 65 GYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGL 124
G K YIR+S DT + L L+ + W L+ P L+ISV GG +NF ++P+++++F + L
Sbjct: 112 G--KKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-L 168
Query: 125 IKAAMTTGAWIFTGGVSTGVISHVGDALKDH--SSKSRGRVCAIGIAPWGIVENKEDLVG 182
I A + GAWI TGG G++ ++G+ ++D+ S S + AIGIA WG+V N++ L+
Sbjct: 169 IYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIR 228
Query: 183 KDVTRVY---QTMSNPLSK--LSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQ 237
Y Q + + ++ L +L+N+HTH +L DNG G E KLR LEK+IS +
Sbjct: 229 NCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISER 288
Query: 238 KI-NTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYC 296
I ++ G +P+V GG + + ++ + IP V+ +GSG+ +D+++ +
Sbjct: 289 TIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNK--IPCVVVEGSGQIADVIASLVEV- 345
Query: 297 EEGGIINESLREQLLVTIQKTFN-YNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDI 355
E + + +++E+L+ + +T + + ++ + E ++ L+TV +M G + +
Sbjct: 346 -EDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIV 404
Query: 356 EMAILTALLKGTNVSAPD------QLSLALAWNRVDIARSQIFVFGPHW 398
AI AL K + S D QL L L WN++D+A +IF W
Sbjct: 405 SNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRW 453
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 88.6 bits (218), Expect = 4e-17
Identities = 144/728 (19%), Positives = 291/728 (39%), Gaps = 154/728 (21%)
Query: 659 SDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTY-------ELKNWSNSTC 711
S + ++ + + S+ Q A +LLDQ+ E +L Y E ++ ++
Sbjct: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
Query: 712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNPGLKVIMGILLPPTILFLEFRTY 769
LKLA+ + ++F+A Q LL W R++ +K++ ++ +LF F
Sbjct: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIG--LLFPVFSV- 345
Query: 770 DDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIV 829
Y + ++ P+G F P +
Sbjct: 346 ---CYLIAPKS----------------------------------PLGL----FIRKPFI 364
Query: 830 KFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEKIREILMS 882
KF +T SYL +L L L R P++ EW+++ +++ +I++ M
Sbjct: 365 KFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ--MW 422
Query: 883 EPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------------- 929
+ G ++ ++ ++WN+ D V S ++ A + L+ ++ Y +
Sbjct: 423 DGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESWDMWHPTL 475
Query: 930 ----IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF----- 980
++ + IF +R++ +F N +LGP + +G+M++D+L F+ I +VL++F
Sbjct: 476 VAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 535
Query: 981 ----------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPC 1030
G+ + I ++ ++ +W I+G I+LY +
Sbjct: 536 QLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYVTNVK--- 587
Query: 1031 GENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 1090
++ + E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 588 AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 1091 KFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
KF R +L M+ F + LP P ++ S Y+I + C+KK ++ G
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMR--RKPESFGTIG 693
Query: 1146 FLSDEELKRLHEFEE-------QCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEE 1198
+ + L+R H+++E + V R+ + E+ + EN ++
Sbjct: 694 RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTE-----------ENFKELKQD 742
Query: 1199 INERETFMKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSECEATYL 1258
I+ + L+ L Q S N+ ++ D + + AR +A+ E
Sbjct: 743 ISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEEEV-ARQQAAGPLERNIQ 801
Query: 1259 LRQSSINSADGYSLYRYHFNGEELLFEDTSLSTSP-GTGVRKKTCSFRIKEEKDVKTHLV 1317
L + S S+ + + +L + +T G V K+ C F K EK V V
Sbjct: 802 LESRGLASRGDLSI--PGLSEQCVLVDHRERNTDTLGLQVGKRVCPF--KSEKVVVEDTV 857
Query: 1318 PECQNSLH 1325
P H
Sbjct: 858 PIIPKEKH 865
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 88.2 bits (217), Expect = 6e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 130/555 (23%)
Query: 659 SDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTY-------ELKNWSNSTC 711
S + ++ + + S+ Q A +LLDQ+ E +L Y E ++ ++
Sbjct: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
Query: 712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNPGLKVIMGILLPPTILFLEFRTY 769
LKLA+ + ++F+A Q LL W R++ +K++ ++ +LF F
Sbjct: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIG--LLFPVFSV- 345
Query: 770 DDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIV 829
Y + ++ P+G F P +
Sbjct: 346 ---CYLIAPKS----------------------------------PLGL----FIRKPFI 364
Query: 830 KFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEKIREILMS 882
KF +T SYL +L L L R P++ EW+++ +++ +I++ M
Sbjct: 365 KFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ--MW 422
Query: 883 EPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------------- 929
+ G ++ ++ ++WN+ D V S ++ A + L+ ++ Y +
Sbjct: 423 DGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESWDMWHPTL 475
Query: 930 ----IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF----- 980
++ + IF +R++ +F N +LGP + +G+M++D+L F+ I +VL++F
Sbjct: 476 VAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 535
Query: 981 ----------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPC 1030
G+ + I ++ ++ +W I+G I+LY +
Sbjct: 536 QLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYVTNVK--- 587
Query: 1031 GENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 1090
++ + E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 588 AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 1091 KFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
KF R +L M+ F + LP P ++ S Y+I + C+KK ++ G
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMR--RKPESFGTIG 693
Query: 1146 FLSDEELKRLHEFEE 1160
+ + L+R H+++E
Sbjct: 694 RRAADNLRRHHQYQE 708
>gi|7706747 transient receptor potential cation channel, subfamily C,
member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 88.2 bits (217), Expect = 6e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 130/555 (23%)
Query: 659 SDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTY-------ELKNWSNSTC 711
S + ++ + + S+ Q A +LLDQ+ E +L Y E ++ ++
Sbjct: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
Query: 712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNPGLKVIMGILLPPTILFLEFRTY 769
LKLA+ + ++F+A Q LL W R++ +K++ ++ +LF F
Sbjct: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIG--LLFPVFSV- 345
Query: 770 DDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIV 829
Y + ++ P+G F P +
Sbjct: 346 ---CYLIAPKS----------------------------------PLGL----FIRKPFI 364
Query: 830 KFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEKIREILMS 882
KF +T SYL +L L L R P++ EW+++ +++ +I++ M
Sbjct: 365 KFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ--MW 422
Query: 883 EPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------------- 929
+ G ++ ++ ++WN+ D V S ++ A + L+ ++ Y +
Sbjct: 423 DGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESWDMWHPTL 475
Query: 930 ----IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF----- 980
++ + IF +R++ +F N +LGP + +G+M++D+L F+ I +VL++F
Sbjct: 476 VAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 535
Query: 981 ----------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPC 1030
G+ + I ++ ++ +W I+G I+LY +
Sbjct: 536 QLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYVTNVK--- 587
Query: 1031 GENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 1090
++ + E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 588 AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 1091 KFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
KF R +L M+ F + LP P ++ S Y+I + C+KK ++ G
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMR--RKPESFGTIG 693
Query: 1146 FLSDEELKRLHEFEE 1160
+ + L+R H+++E
Sbjct: 694 RRAADNLRRHHQYQE 708
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 87.4 bits (215), Expect = 1e-16
Identities = 81/382 (21%), Positives = 173/382 (45%), Gaps = 75/382 (19%)
Query: 823 FYNAPIVKFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEK 875
F P +KF +T SYL +L L L R P++ EW+++ +++ +
Sbjct: 185 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 244
Query: 876 IREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------ 929
I++ M + G ++ ++ ++WN+ D V S ++ A + L+ ++ Y +
Sbjct: 245 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESW 295
Query: 930 -----------IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLM 978
++ + IF +R++ +F N +LGP + +G+M++D+L F+ I +VL+
Sbjct: 296 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLL 355
Query: 979 SF---------------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYA 1023
+F G+ + I ++ ++ +W I+G I+LY
Sbjct: 356 AFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYV 410
Query: 1024 MEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVK 1083
+ ++ + E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 411 TNVK---AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA 455
Query: 1084 SISNQVWKFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLSGRCRKKREGDQEE 1138
++ WKF R +L M+ F + LP P ++ S Y+I + C+KK ++
Sbjct: 456 DHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMR--RKP 513
Query: 1139 RDRGLKLFLSDEELKRLHEFEE 1160
G + + L+R H+++E
Sbjct: 514 ESFGTIGRRAADNLRRHHQYQE 535
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 86.7 bits (213), Expect = 2e-16
Identities = 112/558 (20%), Positives = 235/558 (42%), Gaps = 131/558 (23%)
Query: 659 SDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTY-------ELKNWSNSTC 711
S + ++ + + S+ Q A +LLDQ+ E +L Y E ++ ++
Sbjct: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
Query: 712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNPGLKVIMGILLPPTILFLEFRTY 769
LKLA+ + ++F+A Q LL W R++ +K++ ++ +LF F
Sbjct: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIG--LLFPVFSV- 345
Query: 770 DDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIV 829
Y + ++ P+G F P +
Sbjct: 346 ---CYLIAPKS----------------------------------PLGL----FIRKPFI 364
Query: 830 KFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEKIREILMS 882
KF +T SYL +L L L R P++ EW+++ +++ +I++ M
Sbjct: 365 KFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ--MW 422
Query: 883 EPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------------- 929
+ G ++ ++ ++WN+ D V S ++ A + L+ ++ Y +
Sbjct: 423 DGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESWDMWHPTL 475
Query: 930 ----IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF----- 980
++ + IF +R++ +F N +LGP + +G+M++D+L F+ I +VL++F
Sbjct: 476 VAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 535
Query: 981 ----------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPC 1030
G+ + I ++ ++ +W I+G I+LY +
Sbjct: 536 QLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYVTNVK--- 587
Query: 1031 GENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 1090
++ + E ++ + Y +++ ++L+N+LIA+ NN++ + ++ W
Sbjct: 588 AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
Query: 1091 KFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLSGRCRKK-REGDQEERDRGLK 1144
KF R +L M+ F + LP P ++ S Y+I + C+KK R + G++
Sbjct: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVR 695
Query: 1145 L--FLSDEELKRLHEFEE 1160
+ + L+R H+++E
Sbjct: 696 TQHRRAADNLRRHHQYQE 713
>gi|6912736 transient receptor potential cation channel, subfamily C,
member 5 [Homo sapiens]
Length = 973
Score = 84.7 bits (208), Expect = 6e-16
Identities = 84/371 (22%), Positives = 163/371 (43%), Gaps = 77/371 (20%)
Query: 823 FYNAPIVKFWFYTISYLGYL--LLFNYVILVRMDGW-----PSLQEWIVISYIVSLALEK 875
F P +KF +T SYL +L LL +VR D P++ EW+++ +++ +
Sbjct: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
Query: 876 IREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYG-------- 927
I+E+ G ++ I W WN+ D S ++ A + L+ Y+ Y
Sbjct: 419 IKEMW---DGGFTEYIHDW----WNLMDFAMNSLYL--ATISLKIVAYVKYNGSRPREEW 469
Query: 928 ---------RVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLM 978
++ + I +R++ +F N +LGP + +G+M++D+L F+ I +VL+
Sbjct: 470 EMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLL 529
Query: 979 SFG---------VARQAILHP---------EEKPSWKLARNIFYMPYWMIYGEVFADQID 1020
+F +AI P ++ ++ +W ++G ++
Sbjct: 530 AFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFG-----LLN 584
Query: 1021 LYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFF 1080
LY + + + E ++ + Y +++ ++L+N+LIA+ NN++
Sbjct: 585 LYVTNVK---ARHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQ 629
Query: 1081 EVKSISNQVWKFQRYQLIMTFHDR-PVLPPPMIIL----SHIYIIIMRLSGRCRKKREGD 1135
+ ++ WKF R +L M++ D LPPP I+ S +Y+ + C KR+ D
Sbjct: 630 LIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC-PKRDPD 688
Query: 1136 QEERDRGLKLF 1146
R R L+ F
Sbjct: 689 GRRRRRNLRSF 699
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 77.8 bits (190), Expect = 8e-14
Identities = 112/575 (19%), Positives = 233/575 (40%), Gaps = 142/575 (24%)
Query: 659 SDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTY-------ELKNWSNSTC 711
S + ++ + + S+ Q A +LLDQ+ E +L Y E ++ ++
Sbjct: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
Query: 712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNPGLKVIMGILLPPTILFLEFRTY 769
LKLA+ + ++F+A Q LL W R++ +K++ ++ +LF F
Sbjct: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIG--LLFPVFSV- 345
Query: 770 DDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIV 829
Y + ++ P+G F P +
Sbjct: 346 ---CYLIAPKS----------------------------------PLGL----FIRKPFI 364
Query: 830 KFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEKIREILMS 882
KF +T SYL +L L L R P++ EW+++ +++ +I++ M
Sbjct: 365 KFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ--MW 422
Query: 883 EPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------------- 929
+ G ++ ++ ++WN+ D V S ++ A + L+ ++ Y +
Sbjct: 423 DGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESWDMWHPTL 475
Query: 930 ----IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF----- 980
++ + IF +R++ +F N +LGP + +G+M++D+L F+ I +VL++F
Sbjct: 476 VAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 535
Query: 981 ----------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPC 1030
G+ + I ++ ++ +W I+G I+LY +
Sbjct: 536 QLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYVTNVK--- 587
Query: 1031 GENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 1089
++ + E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 588 AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
Query: 1090 WKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSD 1149
+ +YQ +M ++ ++ +I R K EG EE + LK +S
Sbjct: 636 RRHHQYQEVMR----------NLVKRYVAAMI-----RDAKTEEGLTEENFKELKQDISS 680
Query: 1150 ---EELKRLHEFEEQCVQEHFREKEDEQQSSSDER 1181
E L L + +Q KE + SDE+
Sbjct: 681 FRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK 715
>gi|5730102 transient receptor potential cation channel, subfamily C,
member 6 [Homo sapiens]
Length = 931
Score = 65.1 bits (157), Expect = 5e-10
Identities = 90/449 (20%), Positives = 177/449 (39%), Gaps = 103/449 (22%)
Query: 858 SLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILR 917
S E ++IS+++ + + +EI P K +L E WN+ D ++ F I R
Sbjct: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
Query: 918 LQ----------------------------NQPYMGYGRV-------------IYCVDII 936
N Y R+ +Y + ++
Sbjct: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVV 604
Query: 937 FWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAI----LHPEE 992
+ R+ I N+ GP + +G+ + D+ F+VI ++V ++F + + + ++
Sbjct: 605 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQ 664
Query: 993 KPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLT 1052
++ F +W I+G ++ + N EN+
Sbjct: 665 NEAFTTVEESFKTLFWAIFG---LSEVKSVVINYNHKFIENI-----------------G 704
Query: 1053 PALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHDRPVLPPPM 1111
L Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F + LP P
Sbjct: 705 YVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPF 764
Query: 1112 IIL---SHIYIIIMRL----SGRCRKKREGDQEE-------RDRGLKLFLSDEELKRLHE 1157
++ ++ ++++L S + ++G QE+ ++ L + S E+L +L
Sbjct: 765 NLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSL 824
Query: 1158 FEEQC---VQEHFREKEDEQQSSSDERIRVTSERVENMSMRL----------EEINERET 1204
++Q Q R ED +S + R + ++ + R +E+NE E
Sbjct: 825 DKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGE- 883
Query: 1205 FMKTSLQTV-DLRLAQLEELSNRMVNALE 1232
+K Q + LR LEE S + E
Sbjct: 884 -LKEIKQDISSLRYELLEEKSQNTEDLAE 911
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 62.8 bits (151), Expect = 3e-09
Identities = 61/289 (21%), Positives = 127/289 (43%), Gaps = 36/289 (12%)
Query: 859 LQEWIVISY---IVSLALEKIREILMSEPGKLSQKIKVWLQE--YWNITDLVAISTFMIG 913
LQ W V+ + + +A R + + K Q + ++QE +T I F
Sbjct: 539 LQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYA 598
Query: 914 AILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIM 973
L + P + +Y + ++ + R+ I N+ GP + +G+ + D+ F+V+
Sbjct: 599 RDKWLPSDPQI-ISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLF 657
Query: 974 LVVLMSFGVARQAI----LHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPP 1029
++V +F + + L + ++ F +W I+G ++ ++ +
Sbjct: 658 IMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG---LSEVTSVVLKYDHK 714
Query: 1030 CGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQV 1089
EN + L Y + ++L+N+LIA+ N+++ E++ S+
Sbjct: 715 FIEN-----------------IGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVE 757
Query: 1090 WKFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLS-GRCRKKR 1132
WKF R +L ++ F D LPPP ++ S +Y I+ ++ +CR++R
Sbjct: 758 WKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRR 806
>gi|4507687 transient receptor potential cation channel, subfamily C,
member 3 isoform b [Homo sapiens]
Length = 848
Score = 62.8 bits (151), Expect = 3e-09
Identities = 61/289 (21%), Positives = 127/289 (43%), Gaps = 36/289 (12%)
Query: 859 LQEWIVISY---IVSLALEKIREILMSEPGKLSQKIKVWLQE--YWNITDLVAISTFMIG 913
LQ W V+ + + +A R + + K Q + ++QE +T I F
Sbjct: 466 LQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYA 525
Query: 914 AILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIM 973
L + P + +Y + ++ + R+ I N+ GP + +G+ + D+ F+V+
Sbjct: 526 RDKWLPSDPQI-ISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLF 584
Query: 974 LVVLMSFGVARQAI----LHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPP 1029
++V +F + + L + ++ F +W I+G ++ ++ +
Sbjct: 585 IMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFG---LSEVTSVVLKYDHK 641
Query: 1030 CGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQV 1089
EN + L Y + ++L+N+LIA+ N+++ E++ S+
Sbjct: 642 FIEN-----------------IGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVE 684
Query: 1090 WKFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLS-GRCRKKR 1132
WKF R +L ++ F D LPPP ++ S +Y I+ ++ +CR++R
Sbjct: 685 WKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRR 733
>gi|9966865 transient receptor potential cation channel, subfamily C,
member 7 [Homo sapiens]
Length = 862
Score = 61.2 bits (147), Expect = 8e-09
Identities = 47/226 (20%), Positives = 102/226 (45%), Gaps = 32/226 (14%)
Query: 930 IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILH 989
+Y + ++ + R+ I N+ GP + +G+ + D+ F+VI ++V ++F + +
Sbjct: 543 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 602
Query: 990 ----PEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPC 1045
+ P++ F +W I+G ++ ++ + EN+
Sbjct: 603 YYRGAKYNPAFTTVEESFKTLFWSIFG---LSEVISVVLKYDHKFIENI----------- 648
Query: 1046 IPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDR- 1104
L Y + ++L+N+LIA+ NN++ E++ ++ WKF R +L +++ D
Sbjct: 649 ------GYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEG 702
Query: 1105 PVLPPPMIIL---SHIYIIIMR----LSGRCRKKREGDQEERDRGL 1143
LP P ++ Y +IMR L C+ K + + + + G+
Sbjct: 703 RTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGM 748
>gi|4507685 transient receptor potential cation channel, subfamily C,
member 1 [Homo sapiens]
Length = 759
Score = 57.8 bits (138), Expect = 8e-08
Identities = 101/567 (17%), Positives = 218/567 (38%), Gaps = 117/567 (20%)
Query: 681 LELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGR 740
LE++ DE + + L E N S LKLA+ ++F++ + Q L +W G+
Sbjct: 248 LEVILNHTSSDEPLDKRGLLEERMNLSR---LKLAIKYNQKEFVSQSNCQQFLNTVWFGQ 304
Query: 741 LR-MRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGS 799
+ R+ P K IM +L F Y + +++ G+
Sbjct: 305 MSGYRRKPTCKKIMTVLTVGI-----FWPVLSLCYLIAPKSQFGR--------------- 344
Query: 800 RKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDG---- 855
+ P +KF + SY +LLL N LV +
Sbjct: 345 -----------------------IIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNT 381
Query: 856 -WPSLQ--EWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWN----ITDLVAIS 908
P+L+ ++++I +I+ + I+ + + ++ +L+E N + + + ++
Sbjct: 382 MGPALERIDYLLILWIIGMIWSDIKRLWY-------EGLEDFLEESRNQLSFVMNSLYLA 434
Query: 909 TFMIGAILRLQNQPYMG-----------YGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVM 957
TF + + + + ++ + Y+R+ ++ + LGP +
Sbjct: 435 TFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQI 494
Query: 958 MIGKMMIDMLYFVVIMLVVLMSFGVARQAIL-----------------HPEEKPSWKLAR 1000
+G+M+ D F+ + L+VL SF + + + ++
Sbjct: 495 SMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFI 554
Query: 1001 NIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYL 1060
+ +W I+ + ++ + Y EE + +++ ++ Y
Sbjct: 555 GTCFALFWYIFSLA---HVAIFVTRFS-------YGEELQ--------SFVGAVIVGTYN 596
Query: 1061 LVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHDRPVLPPPMIIL---SH 1116
+V I+L LL+A+ + +F + + ++ WKF R +L ++ F D+ LPPP I+
Sbjct: 597 VVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKT 656
Query: 1117 IYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQC--VQEHFREKEDEQ 1174
I +I LS + +R LK + + ++ + + + C V + +
Sbjct: 657 ICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKM 716
Query: 1175 QSSSDERIRVTSERVENMSMRLEEINE 1201
QS+ + +E +++S EI +
Sbjct: 717 QSTDQATVENLNELRQDLSKFRNEIRD 743
>gi|21735483 transient receptor potential cation channel, subfamily V,
member 3 [Homo sapiens]
Length = 790
Score = 48.9 bits (115), Expect = 4e-05
Identities = 38/151 (25%), Positives = 74/151 (49%), Gaps = 20/151 (13%)
Query: 952 LGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMI 1010
+G Y +MI K+++ D+L F+ + +V L+ FGVA +++ K + +
Sbjct: 572 MGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSS---------- 621
Query: 1011 YGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNL 1070
YG ++L+ + I +L ++ + P L L+ Y+++ +LL+N+
Sbjct: 622 YGSFSDAVLELFKLTIGLG---DLNIQQNSKYPI------LFLFLLITYVILTFVLLLNM 672
Query: 1071 LIAVFNNTFFEVKSISNQVWKFQRYQLIMTF 1101
LIA+ T V S ++W+ QR + I+ F
Sbjct: 673 LIALMGETVENVSKESERIWRLQRARTILEF 703
>gi|21314682 transient receptor potential cation channel, subfamily V,
member 6 [Homo sapiens]
Length = 725
Score = 45.8 bits (107), Expect = 3e-04
Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 22/143 (15%)
Query: 952 LGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMI 1010
LGP+ +MI KM+ D++ F +M VV++ F A I E+ + ++
Sbjct: 475 LGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEE---------LGHFYD 525
Query: 1011 YGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNL 1070
Y +L+ I+ P N+ LP ++ A + ++A +L++NL
Sbjct: 526 YPMALFSTFELFLTIIDGPANYNV------DLP------FMYSITYAAFAIIATLLMLNL 573
Query: 1071 LIAVFNNTFFEVKSISNQVWKFQ 1093
LIA+ +T + V +++W+ Q
Sbjct: 574 LIAMMGDTHWRVAHERDELWRAQ 596
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,794,494
Number of Sequences: 37866
Number of extensions: 2873598
Number of successful extensions: 16725
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 173
Number of HSP's that attempted gapping in prelim test: 15403
Number of HSP's gapped (non-prelim): 1318
length of query: 1603
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1487
effective length of database: 13,855,062
effective search space: 20602477194
effective search space used: 20602477194
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.