Guide to the Human Genome
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Search of human proteins with 14150045

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
         (505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ...  1018   0.0  
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ...  1018   0.0  
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha...   953   0.0  
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2...   595   e-170
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2...   595   e-170
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2...   588   e-168
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2...   588   e-168
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2...   508   e-144
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2...   501   e-142
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2...   501   e-142
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               145   1e-34
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         144   1e-34
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma...   144   2e-34
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   142   5e-34
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   142   5e-34
gi|212549753 calcium/calmodulin-dependent protein kinase II delt...   142   5e-34
gi|26667186 calcium/calmodulin-dependent protein kinase II delta...   142   5e-34
gi|26667189 calcium/calmodulin-dependent protein kinase II delta...   142   5e-34
gi|26667180 calcium/calmodulin-dependent protein kinase II delta...   142   5e-34
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   142   5e-34
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]          142   7e-34
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha...   142   7e-34
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha...   142   7e-34
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...   141   2e-33
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma...   141   2e-33
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma...   141   2e-33
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma...   141   2e-33
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   141   2e-33
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ...   141   2e-33
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   139   5e-33

>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score = 1018 bits (2633), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
           MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1   MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60

Query: 61  LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
           LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61  LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120

Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
           DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180

Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240
           AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240

Query: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
           VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF
Sbjct: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300

Query: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
           EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA
Sbjct: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360

Query: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420
           LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE
Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420

Query: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480
           EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL
Sbjct: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480

Query: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505
           LVKEGFGEGGKSPELPGVQEDEAAS
Sbjct: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505


>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score = 1018 bits (2633), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
           MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1   MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60

Query: 61  LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
           LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61  LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120

Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
           DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180

Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240
           AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME 240

Query: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
           VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF
Sbjct: 241 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300

Query: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
           EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA
Sbjct: 301 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360

Query: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420
           LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE
Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE 420

Query: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480
           EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL
Sbjct: 421 EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL 480

Query: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505
           LVKEGFGEGGKSPELPGVQEDEAAS
Sbjct: 481 LVKEGFGEGGKSPELPGVQEDEAAS 505


>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform b [Homo sapiens]
          Length = 520

 Score =  953 bits (2464), Expect = 0.0
 Identities = 482/520 (92%), Positives = 482/520 (92%), Gaps = 38/520 (7%)

Query: 1   MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
           MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1   MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60

Query: 61  LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
           LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61  LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120

Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
           DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180

Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL------------ 228
           AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL            
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLD 240

Query: 229 --------------------------VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 262
                                     VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG
Sbjct: 241 STNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 300

Query: 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 322
           LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI
Sbjct: 301 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 360

Query: 323 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 382
           SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL
Sbjct: 361 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 420

Query: 383 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 442
           KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP
Sbjct: 421 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 480

Query: 443 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 482
           SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV
Sbjct: 481 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 520


>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score =  595 bits (1534), Expect = e-170
 Identities = 294/450 (65%), Positives = 371/450 (82%), Gaps = 12/450 (2%)

Query: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209

Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269

Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329

Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389

Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449

Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
           G EPLPSE+E+C++VEVTEEEV+NSV+ IPS  TVILVK+M+RKRSFGNPFE  +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508

Query: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
           S+SAPGNLL K+G  +  +  + P V E+E
Sbjct: 509 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 538


>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score =  595 bits (1534), Expect = e-170
 Identities = 294/450 (65%), Positives = 371/450 (82%), Gaps = 12/450 (2%)

Query: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209

Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269

Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329

Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389

Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449

Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
           G EPLPSE+E+C++VEVTEEEV+NSV+ IPS  TVILVK+M+RKRSFGNPFE  +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508

Query: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
           S+SAPGNLL K+G  +  +  + P V E+E
Sbjct: 509 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 538


>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 1 [Homo sapiens]
          Length = 588

 Score =  588 bits (1515), Expect = e-168
 Identities = 289/432 (66%), Positives = 362/432 (83%), Gaps = 12/432 (2%)

Query: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209

Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269

Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329

Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389

Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449

Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
           G EPLPSE+E+C++VEVTEEEV+NSV+ IPS  TVILVK+M+RKRSFGNPFE  +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508

Query: 473 SMSAPGNLLVKE 484
           S+SAPGNLL K+
Sbjct: 509 SLSAPGNLLTKK 520


>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 5 [Homo sapiens]
          Length = 533

 Score =  588 bits (1515), Expect = e-168
 Identities = 289/432 (66%), Positives = 362/432 (83%), Gaps = 12/432 (2%)

Query: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209

Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269

Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329

Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389

Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 449

Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
           G EPLPSE+E+C++VEVTEEEV+NSV+ IPS  TVILVK+M+RKRSFGNPFE  +RREER
Sbjct: 450 GAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREER 508

Query: 473 SMSAPGNLLVKE 484
           S+SAPGNLL K+
Sbjct: 509 SLSAPGNLLTKK 520


>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 4 [Homo sapiens]
          Length = 498

 Score =  508 bits (1309), Expect = e-144
 Identities = 263/450 (58%), Positives = 332/450 (73%), Gaps = 55/450 (12%)

Query: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209

Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269

Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329

Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389

Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK        
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441

Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
                                              ILVK+M+RKRSFGNPFE  +RREER
Sbjct: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465

Query: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502
           S+SAPGNLL K+G  +  +  + P V E+E
Sbjct: 466 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 495


>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 3 [Homo sapiens]
          Length = 545

 Score =  501 bits (1290), Expect = e-142
 Identities = 258/432 (59%), Positives = 323/432 (74%), Gaps = 55/432 (12%)

Query: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209

Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269

Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329

Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389

Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK        
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441

Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
                                              ILVK+M+RKRSFGNPFE  +RREER
Sbjct: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465

Query: 473 SMSAPGNLLVKE 484
           S+SAPGNLL K+
Sbjct: 466 SLSAPGNLLTKK 477


>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 6 [Homo sapiens]
          Length = 490

 Score =  501 bits (1290), Expect = e-142
 Identities = 258/432 (59%), Positives = 323/432 (74%), Gaps = 55/432 (12%)

Query: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209

Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269

Query: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329

Query: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389

Query: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK        
Sbjct: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441

Query: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
                                              ILVK+M+RKRSFGNPFE  +RREER
Sbjct: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465

Query: 473 SMSAPGNLLVKE 484
           S+SAPGNLL K+
Sbjct: 466 SLSAPGNLLTKK 477


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  145 bits (365), Expect = 1e-34
 Identities = 89/295 (30%), Positives = 156/295 (52%), Gaps = 32/295 (10%)

Query: 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPA 187
           Y+L+  +GKG  G+V+L  +    +  A+K+++++KL +                     
Sbjct: 34  YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESV------------------- 74

Query: 188 KQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKP- 246
                L +V +EIAILK ++H +V+KL +V ++  +  LYLV + +  G + +    K  
Sbjct: 75  -----LMKVEREIAILKLIEHPHVLKLHDVYEN--KKYLYLVLEHVSGGELFDYLVKKGR 127

Query: 247 FSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQ 306
            + ++AR + R ++  L++ H   I HRD+KP NLLL +  +++IADFG+++  +  D+ 
Sbjct: 128 LTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS-LQVGDSL 186

Query: 307 LSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIK 366
           L ++ G+P +  PE I   G+ + G+  D+W+ GV L+  + G  PF DD +  L  K+K
Sbjct: 187 LETSCGSPHYACPEVI--KGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVK 244

Query: 367 NEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEE 421
               VF     I  + + L+  M++  PE R+ +  I+ HPW      EP P  E
Sbjct: 245 RG--VFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLE 297


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  144 bits (364), Expect = 1e-34
 Identities = 87/288 (30%), Positives = 150/288 (52%), Gaps = 32/288 (11%)

Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
           V++  Y ++  +GKG + VV+L  +       A+K++ K +L                  
Sbjct: 15  VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL------------------ 56

Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 242
                   + LE++Y+E+ I+K LDH +++KL +V++   +  LYLV +  + G + +  
Sbjct: 57  ------DAVNLEKIYREVQIMKMLDHPHIIKLYQVME--TKSMLYLVTEYAKNGEIFDYL 108

Query: 243 CDKP-FSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
            +    +E +AR     ++  ++Y H +KIVHRD+K  NLLL ++ ++KIADFG  N F+
Sbjct: 109 ANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFK 168

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
             +  L++  G+P + APE     GQ + G  LD+W+ GV LY  V G  PF    +  L
Sbjct: 169 SGEL-LATWCGSPPYAAPEVF--EGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL 225

Query: 362 HRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
            +++       P    +SE+ + LI +ML  +P  R+ +  IK H W+
Sbjct: 226 RQRVLEGRFRIPY--FMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM 271


>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
           isoform 4 [Homo sapiens]
          Length = 495

 Score =  144 bits (362), Expect = 2e-34
 Identities = 111/356 (31%), Positives = 170/356 (47%), Gaps = 49/356 (13%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           + Y+L  E+GKGA+ VVR    ++  + YA K+++ KKL                     
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
           + +SE  A   +  ++  + ++H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G        AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPL-- 417
           +++IK     F  PE   ++ E K+LI +ML  NP  RI       HPWV +        
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMM 282

Query: 418 -PSEEEHCSVVEVTEEEVKNSVRLIPSWTTVIL------VKSMLRKRSFGNPFEPQ 466
              E   C        ++K ++      TT+++       KS+L K+S G   EPQ
Sbjct: 283 HRQETVECLRKFNARRKLKGAI-----LTTMLVSRNFSAAKSLLNKKSDGGVKEPQ 333


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  142 bits (359), Expect = 5e-34
 Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           ++Y+L  E+GKGA+ VVR        + YA K+++ KKL                     
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
           + +SE  A   ++ ++  + + H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G+       AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  142 bits (359), Expect = 5e-34
 Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           ++Y+L  E+GKGA+ VVR        + YA K+++ KKL                     
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
           + +SE  A   ++ ++  + + H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G+       AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
           isoform 5 [Homo sapiens]
          Length = 492

 Score =  142 bits (359), Expect = 5e-34
 Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           ++Y+L  E+GKGA+ VVR        + YA K+++ KKL                     
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
           + +SE  A   ++ ++  + + H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G+       AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  142 bits (359), Expect = 5e-34
 Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           ++Y+L  E+GKGA+ VVR        + YA K+++ KKL                     
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
           + +SE  A   ++ ++  + + H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G+       AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  142 bits (359), Expect = 5e-34
 Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           ++Y+L  E+GKGA+ VVR        + YA K+++ KKL                     
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
           + +SE  A   ++ ++  + + H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G+       AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
           isoform 3 [Homo sapiens]
          Length = 499

 Score =  142 bits (359), Expect = 5e-34
 Identities = 98/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           ++Y+L  E+GKGA+ VVR        + YA K+++ KKL                     
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFE 301
           + +SE  A   ++ ++  + + H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G+       AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 362 HRKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW+
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  142 bits (359), Expect = 5e-34
 Identities = 103/322 (31%), Positives = 160/322 (49%), Gaps = 36/322 (11%)

Query: 98  HISP-RAWRRPTIESHHVAISDAED-CVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYA 155
           HI P ++  R  I     +I+ A D    +  Y+LQ  IGKG +  V+LA +    R  A
Sbjct: 28  HIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVA 87

Query: 156 MKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLI 215
           +K++ K +L                     P      L+++++E+ I+K L+H N+VKL 
Sbjct: 88  VKIIDKTQL--------------------NPTS----LQKLFREVRIMKILNHPNIVKLF 123

Query: 216 EVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHR 274
           EV++   E  LYLV +    G V + +       E++AR   R ++  ++Y H + IVHR
Sbjct: 124 EVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 181

Query: 275 DIKPSNLLLGDDGHVKIADFGVSNQFE-GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKA 333
           D+K  NLLL  D ++KIADFG SN+F  GN  +L +  G+P + APE     G+ + G  
Sbjct: 182 DLKAENLLLDGDMNIKIADFGFSNEFTVGN--KLDTFCGSPPYAAPELF--QGKKYDGPE 237

Query: 334 LDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKN 393
           +DVW+ GV LY  V G  PF    +  L  ++       P    +S + ++L+ K+L  N
Sbjct: 238 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF--YMSTDCENLLKKLLVLN 295

Query: 394 PETRIGVPDIKLHPWVTKNGEE 415
           P  R  +  I    W+    EE
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEE 317


>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
          Length = 433

 Score =  142 bits (358), Expect = 7e-34
 Identities = 100/301 (33%), Positives = 147/301 (48%), Gaps = 32/301 (10%)

Query: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 184
           + +Y +   +G+G+YG V+   +       A+K+L KKKL        R  P G      
Sbjct: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL--------RRIPNGEA---- 93

Query: 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 242
                      V +EI +L++L H NV++L++VL +  +  +Y+V +    G   +++  
Sbjct: 94  ----------NVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143

Query: 243 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 301
            +K F   QA  Y   +I GLEYLH Q IVH+DIKP NLLL   G +KI+D GV+     
Sbjct: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203

Query: 302 -GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360
              D    ++ G+PAF  PE I++   +FSG  +D+W+ GVTLY    G  PF  D I  
Sbjct: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262

Query: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN---GEEPL 417
           L   I       P   +    L DL+  ML+  P  R  +  I+ H W  K     E P+
Sbjct: 263 LFENIGKGSYAIP--GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPV 320

Query: 418 P 418
           P
Sbjct: 321 P 321


>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  142 bits (358), Expect = 7e-34
 Identities = 97/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 186
           +Y+L  E+GKGA+ VVR        + YA K+++ KKL                      
Sbjct: 12  EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL---------------------S 50

Query: 187 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDK 245
           A+    LER   E  I + L H N+V+L + + +  E + YL+FDL+  G + E +   +
Sbjct: 51  ARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105

Query: 246 PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEG 302
            +SE  A   ++ ++  + + H   +VHRD+KP NLLL        VK+ADFG++ + EG
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165

Query: 303 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 362
                   AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222

Query: 363 RKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVT 410
           ++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272


>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
           isoform 1 [Homo sapiens]
          Length = 489

 Score =  142 bits (358), Expect = 7e-34
 Identities = 97/290 (33%), Positives = 147/290 (50%), Gaps = 35/290 (12%)

Query: 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 186
           +Y+L  E+GKGA+ VVR        + YA K+++ KKL                      
Sbjct: 12  EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL---------------------S 50

Query: 187 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDK 245
           A+    LER   E  I + L H N+V+L + + +  E + YL+FDL+  G + E +   +
Sbjct: 51  ARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105

Query: 246 PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEG 302
            +SE  A   ++ ++  + + H   +VHRD+KP NLLL        VK+ADFG++ + EG
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165

Query: 303 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 362
                   AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222

Query: 363 RKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVT 410
           ++IK     FP  E   ++ E KDLI KML  NP  RI   +   HPW++
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  141 bits (355), Expect = 2e-33
 Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           + Y+L  E+GKGA+ VVR    ++  + YA K+++ KKL                     
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
           + +SE  A   +  ++  + ++H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G        AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     F  PE   ++ E K+LI +ML  NP  RI       HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
           isoform 6 [Homo sapiens]
          Length = 504

 Score =  141 bits (355), Expect = 2e-33
 Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           + Y+L  E+GKGA+ VVR    ++  + YA K+++ KKL                     
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
           + +SE  A   +  ++  + ++H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G        AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     F  PE   ++ E K+LI +ML  NP  RI       HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
           isoform 1 [Homo sapiens]
          Length = 556

 Score =  141 bits (355), Expect = 2e-33
 Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           + Y+L  E+GKGA+ VVR    ++  + YA K+++ KKL                     
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
           + +SE  A   +  ++  + ++H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G        AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     F  PE   ++ E K+LI +ML  NP  RI       HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
           isoform 2 [Homo sapiens]
          Length = 527

 Score =  141 bits (355), Expect = 2e-33
 Identities = 97/290 (33%), Positives = 146/290 (50%), Gaps = 35/290 (12%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           + Y+L  E+GKGA+ VVR    ++  + YA K+++ KKL                     
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQFE 301
           + +SE  A   +  ++  + ++H   IVHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G        AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 409
           +++IK     F  PE   ++ E K+LI +ML  NP  RI       HPWV
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  141 bits (355), Expect = 2e-33
 Identities = 92/331 (27%), Positives = 164/331 (49%), Gaps = 45/331 (13%)

Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
           V++  Y L   +G G +G V++  ++      A+K+L+++K+                  
Sbjct: 11  VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI------------------ 52

Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 242
                + L  + ++ +EI  LK   H +++KL +V+  P +   ++V + +  G + +  
Sbjct: 53  -----RSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYI 105

Query: 243 CDKPFSEE-QARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
           C     EE +AR   + ++  ++Y H   +VHRD+KP N+LL    + KIADFG+SN   
Sbjct: 106 CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
             +  L ++ G+P + APE I  SG+ ++G  +D+W+ GV LY  + G  PF D+ +  L
Sbjct: 166 DGEF-LRTSCGSPNYAAPEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222

Query: 362 HRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN------GEE 415
            +KI+      PE   ++  +  L++ ML  +P  R  + DI+ H W  ++       E+
Sbjct: 223 FKKIRGGVFYIPE--YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 280

Query: 416 PL--------PSEEEHCSVVEVTEEEVKNSV 438
           P          + +E C   E TE EV NS+
Sbjct: 281 PSYDANVIDDEAVKEVCEKFECTESEVMNSL 311


>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
           isoform 4 [Homo sapiens]
          Length = 517

 Score =  141 bits (355), Expect = 2e-33
 Identities = 109/360 (30%), Positives = 170/360 (47%), Gaps = 40/360 (11%)

Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
           ++Y+L  +IGKGA+ VVR          YA K+++ KKL                     
Sbjct: 12  DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKL--------------------- 50

Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCD 244
            A+    LER   E  I + L H N+V+L + + +  E   YLVFDL+  G + E +   
Sbjct: 51  SARDHQKLER---EARICRLLKHSNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 245 KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFE 301
           + +SE  A   ++ ++  + + H   +VHRD+KP NLLL        VK+ADFG++ + +
Sbjct: 106 EYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
           G+       AGTP +++PE +        GK +D+WA GV LY  + G  PF D+    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVLRKEAY---GKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 362 HRKIKNEPVVF--PEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPL-- 417
           +++IK     F  PE   ++ E K+LI +ML  NP  RI   +   HPWV +        
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMM 282

Query: 418 -PSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSA 476
              E   C        ++K ++      T     KS+L K++ G   +PQ    + S +A
Sbjct: 283 HRQETVECLKKFNARRKLKGAILTTMLATRNFSAKSLLNKKADG--VKPQTNSTKNSAAA 340


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  139 bits (351), Expect = 5e-33
 Identities = 86/314 (27%), Positives = 162/314 (51%), Gaps = 31/314 (9%)

Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
           V++  Y L   +G G +G V++  +E      A+K+L+++K+                  
Sbjct: 22  VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKI------------------ 63

Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 242
                + L  + ++ +EI  LK   H +++KL +V+  P++  +++V + +  G + +  
Sbjct: 64  -----RSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSD--IFMVMEYVSGGELFDYI 116

Query: 243 CDKP-FSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
           C      E+++R   + ++ G++Y H   +VHRD+KP N+LL    + KIADFG+SN   
Sbjct: 117 CKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 176

Query: 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 361
             +  L ++ G+P + APE I  SG+ ++G  +D+W++GV LY  + G  PF DD +  L
Sbjct: 177 DGEF-LRTSCGSPNYAAPEVI--SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTL 233

Query: 362 HRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEE 421
            +KI +   +F     ++  +  L+  ML  +P  R  + DI+ H W  ++  + L  E+
Sbjct: 234 FKKICDG--IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPED 291

Query: 422 EHCSVVEVTEEEVK 435
              S   + +E +K
Sbjct: 292 PSYSSTMIDDEALK 305


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.135    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,018,681
Number of Sequences: 37866
Number of extensions: 1182294
Number of successful extensions: 5376
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 731
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 3167
Number of HSP's gapped (non-prelim): 1153
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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