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Search of human proteins with 14149807
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo
sapiens]
(558 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo sap... 1120 0.0
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 112 1e-24
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 110 4e-24
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 105 8e-23
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 104 2e-22
gi|148746195 trichohyalin [Homo sapiens] 102 9e-22
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 102 1e-21
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 99 8e-21
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 96 7e-20
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 95 1e-19
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 95 1e-19
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 93 6e-19
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 93 7e-19
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 92 1e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 92 2e-18
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 91 3e-18
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 87 3e-17
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 87 4e-17
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 85 2e-16
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 84 3e-16
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 84 3e-16
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s... 84 3e-16
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 84 3e-16
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 84 3e-16
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 82 1e-15
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 82 1e-15
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 80 6e-15
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 80 6e-15
gi|18375528 UPF3 regulator of nonsense transcripts homolog B iso... 79 8e-15
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 78 2e-14
>gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo
sapiens]
Length = 558
Score = 1120 bits (2898), Expect = 0.0
Identities = 558/558 (100%), Positives = 558/558 (100%)
Query: 1 MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKL 60
MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKL
Sbjct: 1 MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKL 60
Query: 61 EIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEK 120
EIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEK
Sbjct: 61 EIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEK 120
Query: 121 RMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDL 180
RMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDL
Sbjct: 121 RMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDL 180
Query: 181 SGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKV 240
SGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKV
Sbjct: 181 SGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKV 240
Query: 241 EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST 300
EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST
Sbjct: 241 EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST 300
Query: 301 RHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHE 360
RHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHE
Sbjct: 301 RHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHE 360
Query: 361 QEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEH 420
QEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEH
Sbjct: 361 QEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEH 420
Query: 421 MKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAK 480
MKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAK
Sbjct: 421 MKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAK 480
Query: 481 DKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYL 540
DKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYL
Sbjct: 481 DKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYL 540
Query: 541 ARQMARVNAKTYIEKEDD 558
ARQMARVNAKTYIEKEDD
Sbjct: 541 ARQMARVNAKTYIEKEDD 558
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 112 bits (279), Expect = 1e-24
Identities = 115/552 (20%), Positives = 234/552 (42%), Gaps = 53/552 (9%)
Query: 31 NDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENN 90
+DS ++S SES E +KK+ K K + + S E + + E
Sbjct: 208 SDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQ 267
Query: 91 PKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKK 150
P+ + + P N + K EK + + +RERE E + + A +Y++
Sbjct: 268 PQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNR-ERERERECNPPNSQPA----SYQR 322
Query: 151 KLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSG-- 208
+L + + R ++ +D +R +E+ + SG
Sbjct: 323 RLLVTRSGRKIKGRGPRRYRTPSRSRSRDR---FRRSETPPHWRQEMQRAQRMRVSSGER 379
Query: 209 -IKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNC 267
IK +KS NE+ R P + + K+ ++ + + K+ + ++++ + N
Sbjct: 380 WIKGDKSE--LNEIKENQRSP----VRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNS 433
Query: 268 RREKVIETPENDFKHH-----RSQNHSRSPSEERGHS----TRHHTKGSRTSRGHEKRED 318
+ + E D K+ R+++ SRS S+E+ S ++H+ + R K D
Sbjct: 434 KERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRD 493
Query: 319 QHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVW 378
H+ + +++++ +D + R + ++ + + + ++K R R R +
Sbjct: 494 -HENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDI- 551
Query: 379 KREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDRE 438
K + Y+ R +ER R ++ R + ++S++KE H + R++ Y + R RE
Sbjct: 552 --TKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYH-RYREQEYRRRGRSRSRE 608
Query: 439 KREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPS-----NSE 493
+R +S R++DR+ +SR+ ++ Q R+ KDK RNQE S NSE
Sbjct: 609 RRTPPGRS--RSKDRRRRRRDSRSSEREESQSRN-------KDKYRNQESKSSHRKENSE 659
Query: 494 S-----SLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNE---ETVMSARDRYLARQMA 545
S S H + +EK ++++ P + K + ++NE + + D + +
Sbjct: 660 SEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVE 719
Query: 546 RVNAKTYIEKED 557
+ N K+ ++ D
Sbjct: 720 KENQKSKGQEND 731
Score = 73.6 bits (179), Expect = 5e-13
Identities = 103/447 (23%), Positives = 175/447 (39%), Gaps = 109/447 (24%)
Query: 87 EENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRME--KKIQREREMEKG-EFDDKEAF 143
+EN + K+RK N+ ++ RK E+EK+++ K +ER++ + E DDK
Sbjct: 392 KENQRSPVRVKERKITDHRNVSESPN-RKNEKEKKVKDHKSNSKERDIRRNSEKDDK--- 447
Query: 144 VTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFR 203
YK K+++RA+ + R K +E K R
Sbjct: 448 ----YKNKVKKRAKSKSRSK------------------------------SKEKSKSKER 473
Query: 204 EARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEET 263
+++ EEK SK R + +VK +E D + S E
Sbjct: 474 DSKHNRNEEKRM----RSRSKGRDHE-------NVKEKEKQSDSKGKDQERSRSKE---- 518
Query: 264 RVNCRREKVIETPENDFKHHRSQNHSR---SPSEERGHSTRHHTKGSRTSRGHEKREDQH 320
+ K +E+ N+ H +S+ R S S E + H+ SRT RE
Sbjct: 519 -----KSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRT------RERSR 567
Query: 321 QQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKP----RARDQRER--- 373
+ +SR + DRD + ++ HR+RE +R R + P R++D+R R
Sbjct: 568 SRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRD 627
Query: 374 ---SDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYEN 430
S+R + ++++KY +E + + KE K + K R N
Sbjct: 628 SRSSEREESQSRNKDKYRNQESKSSHR------------KENSESEKRMYSKSRDHNSSN 675
Query: 431 NDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQE-RSNKMRNMAKDKERNQEKP 489
N S E+ DR + SP S+ K D E +S+ ++N +K R+ +
Sbjct: 676 N--------------SREKKADR-DQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEK 720
Query: 490 SNSESSLGAKHRLTEEGQEKGKEQERP 516
N +S G ++ E +K + P
Sbjct: 721 ENQKSK-GQENDHVHEKNKKFDHESSP 746
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/413 (20%), Positives = 157/413 (38%), Gaps = 87/413 (21%)
Query: 210 KEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRR 269
KEEK R S+ SS + + D+DS D++SS+D E+ +
Sbjct: 185 KEEKKRHKSSSSSSSS-----------------SSDSDSSSDSQSSSDSSDSESATEEKS 227
Query: 270 EKVIETPENDFKHHRSQNHSRSPSEERGHS------------------------------ 299
+K + + + H+ + R S++ S
Sbjct: 228 KKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLM 287
Query: 300 TRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDR-------DYRKERDSHRHREASHR 352
+ K R + +RE + + Q Y R K R R+R S
Sbjct: 288 RKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRS 347
Query: 353 DSHWKRHEQEDKPRARDQRERSDRV-------W----KREKDREKYSQREQERDRQ---- 397
S + E P R + +R+ R+ W K E + K +QR R ++
Sbjct: 348 RSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKIT 407
Query: 398 --QNDQNRPSEKGEKEEKSKAKEEHMKVR--KERYENNDKYRDREKREVGVQSSERNQDR 453
+N P+ K EKE+K K + + K R + E +DKY+++ K+ +S +++++
Sbjct: 408 DHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEK 467
Query: 454 KESSPNS-----------RAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRL 502
+S R++ K D E + + K ++QE+ + E S + +
Sbjct: 468 SKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKS 527
Query: 503 TEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLAR---QMARVNAKTY 552
E K KE++R ++ S+ + ++R R +R + RV ++T+
Sbjct: 528 NEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580
Score = 46.6 bits (109), Expect = 6e-05
Identities = 54/291 (18%), Positives = 104/291 (35%), Gaps = 50/291 (17%)
Query: 306 GSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKP 365
G + K+E++ + K S + +D D DS ++S +S E++ K
Sbjct: 175 GELIPKSKVKKEEKKRHKSSSSSSSSSSDSD--SSSDSQSSSDSSDSES---ATEEKSKK 229
Query: 366 RARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRK 425
R + R+ S + K +K R+K + +N + +P EE E +RK
Sbjct: 230 RKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRK 289
Query: 426 ERYENNDKYRDREKRE-----------------------VGVQSSERNQDRKESSPNSRA 462
+ ++K R +RE G + R R + SR+
Sbjct: 290 SPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRS 349
Query: 463 KDKF----------LDQERSNKMRNMAKDK------------ERNQEKPSNSESSLGAKH 500
+D+F + +R+ +MR + ++ + NQ P + H
Sbjct: 350 RDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDH 409
Query: 501 RLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKT 551
R E + E+E+ + +K + D+Y + R +K+
Sbjct: 410 RNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKS 460
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 110 bits (274), Expect = 4e-24
Identities = 98/450 (21%), Positives = 191/450 (42%), Gaps = 64/450 (14%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
R+KE+E+R EK+ Q ERE ++ K + R E++ KR E D
Sbjct: 58 RQKERERRREKR-QTERETDR----------------KRERRREKDRHRKRDRHRERQRD 100
Query: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCI 233
K+++ R + + E + +E + E RG + + +++
Sbjct: 101 REKERE-----RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR-- 153
Query: 234 LQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHS-RSP 292
D + E D + ++ + + E R R+E+ + + ++ HS R
Sbjct: 154 ---DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGR 210
Query: 293 SEERGHSTRHHTKGSR-----------TSRGHEKREDQHQQKQSRDQENHYTDRDYRKER 341
ER T T+ R T R EK+ ++ + + + + +R+ ++R
Sbjct: 211 ERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDR 270
Query: 342 DSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQ 401
D R ++ R + KR + ++ R +++ R +RE++R + +RE+ER+R++ Q
Sbjct: 271 DRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQ 330
Query: 402 NRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSR 461
EKE + K K R D+ R+R+ G + +ER ++R+
Sbjct: 331 RETERDREKERERKRK---------RQTEMDRERNRQTGREGRRQAERERERERERDRQS 381
Query: 462 AKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSL-----GAKHRLTEEGQEKGKEQERP 516
A+++ ++ ++ R+ K++ER EK + + K R +E G+E+G+E+E+
Sbjct: 382 ARER--EERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREK- 438
Query: 517 PEAVSKFAKRNNEETVMSARDRYLARQMAR 546
K +R+ E DR RQ R
Sbjct: 439 ----QKGRERDRERQT----DRQAGRQRKR 460
Score = 105 bits (263), Expect = 8e-23
Identities = 78/329 (23%), Positives = 150/329 (45%), Gaps = 31/329 (9%)
Query: 241 EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST 300
+ + DAD D D + + E E RREK E D K R + R +R
Sbjct: 44 QAHKDADGD-DRERNRQKERER-----RREKRQTERETDRKRERRREKDRHRKRDR---- 93
Query: 301 RHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREAS---------H 351
H + + E++ D+ + +Q + N +R+ ER+ R R+
Sbjct: 94 -HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQ 152
Query: 352 RDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKE 411
RD+ +R Q D+ R R + +REK+R++ +RE++R+++ ++R SE+G +
Sbjct: 153 RDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRER 212
Query: 412 EKSKAKEEHMKVRKERYENNDKY----RDREKREVGVQSSERNQDRKESSPNSRAKDKFL 467
E+ + E + +++ D+ R+REK+ ++SER +R + R +D+
Sbjct: 213 ERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 468 DQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRN 527
D+ + + R + ++R E+ +E + R E +E+ +++ER E +R
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERK-RERQRERERERERNRKRERERE-----RERE 326
Query: 528 NEETVMSARDRYLARQMARVNAKTYIEKE 556
E + RDR R+ R +T +++E
Sbjct: 327 RERQRETERDREKERERKR-KRQTEMDRE 354
Score = 103 bits (257), Expect = 4e-22
Identities = 78/334 (23%), Positives = 158/334 (47%), Gaps = 22/334 (6%)
Query: 235 QTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSE 294
QT+ + + + + D D E R REK E + D + R + R+ +
Sbjct: 70 QTERETDRKRERRREKDRHRKRDRHRERQR---DREKERER-QTDRERDRQREKERNRQK 125
Query: 295 ERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKE----RDSHRHREAS 350
ER T + R + +RE + Q+ +++E TDR+ +++ R R RE +
Sbjct: 126 ERERETEREGERGRDRQTDGQRERERQRDAEKERERQ-TDRERQRQTERNRQKEREREKN 184
Query: 351 HRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEK 410
++ + ++E + + D+ R +RE++ E ++R+++ DR+++ Q + + EK
Sbjct: 185 RQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREK 244
Query: 411 E-EKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQ 469
+ E+ +A E + KER D+ RDR++R+ + ER DRK R ++ +
Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQ---KERERQTDRKRQRRTERDRE---TE 298
Query: 470 ERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNE 529
+ + R +++ERN+++ E + R E +++ KE+ER + ++ + N
Sbjct: 299 RKRERQRERERERERNRKRERERERE-RERERQRETERDREKERERKRKRQTEMDRERNR 357
Query: 530 ET-----VMSARDRYLARQMARVNAKTYIEKEDD 558
+T + R+R R+ R +A+ E+E D
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERD 391
Score = 100 bits (250), Expect = 3e-21
Identities = 106/504 (21%), Positives = 217/504 (43%), Gaps = 45/504 (8%)
Query: 32 DSDDDD-ETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENN 90
D+D DD E + + +R K+Q ++T + ++ +D + D + + +++E
Sbjct: 48 DADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRH-RKRDRHRERQRDREKERE 106
Query: 91 PKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKK 150
+ +DR+ R+KE+ ++ E++ + ERE E+G D++ T ++
Sbjct: 107 RQTDRERDRQ-------------REKERNRQKERERETEREGERGR--DRQ---TDGQRE 148
Query: 151 KLQERAEEEEREK---RAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARS 207
+ ++R E+ERE+ R + + K+++ + + E+ K R +
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSER 208
Query: 208 GIKEEKSRGFSNEVSSKNRIPQE-----KCILQTDVKVEENPDADSDFDAKSSADDEIEE 262
G + E+ R E K + +E K + + + E ++ + + + E +
Sbjct: 209 GRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDR 268
Query: 263 TRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST---RHHTKGSRTSRGHEK-RED 318
R RR+K E + D K R R +R R + + R E+ RE
Sbjct: 269 DRDRDRRQKERER-QTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERER 327
Query: 319 QHQQKQSRDQENHYTDRDYRKERDSHRHREASH---RDSHWKRHEQEDKPRARDQ---RE 372
+ Q++ RD+E +R+ +++R + RE + R+ + + ++ R RD+ RE
Sbjct: 328 ERQRETERDREK---ERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARE 384
Query: 373 RSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENND 432
R +R R++DR+K +R+ E+DR D R +EK + EK + E + +ER +
Sbjct: 385 REERERDRDRDRQKERERQTEKDR---DGQRETEKQREREKDRESERGRERGREREKQKG 441
Query: 433 KYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNS 492
+ RDRE++ +R + +P R + Q N+ + K ++ + S
Sbjct: 442 RERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAAS 501
Query: 493 ESSLGAKHRLTEEGQEKGKEQERP 516
+ G+ G+ + P
Sbjct: 502 TRFPWGRPAKASRGRVAGRRRWEP 525
Score = 94.4 bits (233), Expect = 3e-19
Identities = 70/267 (26%), Positives = 122/267 (45%), Gaps = 19/267 (7%)
Query: 284 RSQNHSRSPSEERGHSTRHH-TKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERD 342
R + S+ RG H G R +K ++ ++K+ ++E TDR + R+
Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERE---TDRKRERRRE 84
Query: 343 SHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQ----- 397
RHR+ RD H +R +K R R DR ++E++R+K +RE ER+ +
Sbjct: 85 KDRHRK---RDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141
Query: 398 QNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESS 457
Q D R E+ EK + ++ + +++ N K R+REK + ER Q KE+
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERER-QREKENK 200
Query: 458 PNSRAKDKFLDQERSNKM-----RNMAKDKERNQEKPSNSESSLGA-KHRLTEEGQEKGK 511
R ++ ++ER + R D+ER++++ + E A + R +E E+ K
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDK 260
Query: 512 EQERPPEAVSKFAKRNNEETVMSARDR 538
E+ER + +R E + R R
Sbjct: 261 ERERERDRDRDRDRRQKERERQTDRKR 287
Score = 85.5 bits (210), Expect = 1e-16
Identities = 74/353 (20%), Positives = 147/353 (41%), Gaps = 17/353 (4%)
Query: 208 GIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNC 267
G E++R E + R + + + + + E++ D + D E E R
Sbjct: 51 GDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTD 110
Query: 268 RREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRD 327
R E + + R + R R T + R ++RE Q +++ R
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170
Query: 328 QENHYT-------DRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKR 380
E + +R R+ER+ R +E D H +R + ++ R + R R
Sbjct: 171 TERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR 230
Query: 381 EKDR------EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKY 434
E+DR E+ Q E+ER + + R E+ + ++ + ++ K R ER + +
Sbjct: 231 ERDRQRKTEREREKQAERER-ASERETERDKERERERDRDRDRDRRQKER-ERQTDRKRQ 288
Query: 435 RDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERS-NKMRNMAKDKERNQEKPSNSE 493
R E+ + ER ++R+ +R +++ ++ER + R +D+E+ +E+ +
Sbjct: 289 RRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQ 348
Query: 494 SSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMAR 546
+ + + R + G+E ++ ER E + +++ E RDR RQ R
Sbjct: 349 TEMD-RERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKER 400
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 105 bits (263), Expect = 8e-23
Identities = 109/486 (22%), Positives = 203/486 (41%), Gaps = 54/486 (11%)
Query: 44 SLQREAAKKQAMKQTKLEIQKALA----EDATVYEYDSIYDEMQKKKEENNPKLLLGKDR 99
S+QR + + + Q+ L A+ Y S+ +K+ + + K R
Sbjct: 341 SIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGR 400
Query: 100 KPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEE 159
H+ + + + E+R + + +R+RE + E + E +S+ + +R +
Sbjct: 401 -----HDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHR-DDREPRD 454
Query: 160 EREKRAAA-------LEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEE 212
R++R A L D+ +++ + R E P+ S R R +
Sbjct: 455 GRDRRDARDTRDRRELRDSRDMRDSREMRDYSRD-----TKESRDPRDS-RSTRDA-HDY 507
Query: 213 KSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKV 272
+ R + ++ P+E + EE+ + ++++ + EI R+ R +V
Sbjct: 508 RDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRV 567
Query: 273 IETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHY 332
E PE + R S+ HS+ + S +R D++ ++ +RDQ
Sbjct: 568 PELPEKGSRGSRG-------SQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS 620
Query: 333 TDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQR---ERSDRVWKREKDREKYSQ 389
+ ERD +RE R S RH+ + RD+R R DRV R +R +
Sbjct: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD 680
Query: 390 REQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSER 449
RE+ERDR ++ R E+ E+ K +E + +ER +K RDRE+ +R
Sbjct: 681 RERERDR---ERERERERERDREREKERELERERAREREREREKERDRER------DRDR 731
Query: 450 NQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEK 509
+ DR+ R ++K ++ER + R +++ER +E + R E +E+
Sbjct: 732 DHDRERERERERDREKEREREREERERERERERERERE-----------RERERERARER 780
Query: 510 GKEQER 515
KE+ER
Sbjct: 781 DKERER 786
Score = 94.7 bits (234), Expect = 2e-19
Identities = 123/574 (21%), Positives = 231/574 (40%), Gaps = 82/574 (14%)
Query: 2 AIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLE 61
A P + L P++ Q P + + D + TS S + E + K+ +
Sbjct: 371 ASPYPSHSLSSPQRKQS--PPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR-- 426
Query: 62 IQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKR 121
+K E+ EY+ + +++ P+ G+DR+ + +E R
Sbjct: 427 -EKDSREER---EYEQDQSSSRDHRDDREPRD--GRDRRD---------ARDTRDRRELR 471
Query: 122 MEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLS 181
+ ++ REM D KE+ + ++ + +RE R + + T ++
Sbjct: 472 DSRDMRDSREMRDYSRDTKESR-DPRDSRSTRDAHDYRDREGRDTHRK---EDTYPEESR 527
Query: 182 GFYRHLLNQAVGEEEVPKCSFREARSGIKEEK------------------SRGFSNEVSS 223
+ R+ L + E+ S E+RS I+ ++ SRG + S
Sbjct: 528 SYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHS 587
Query: 224 KNRIPQEKCILQTDVKVEEN-PDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKH 282
N + ++ + P+ D+ A+ S+ + R + + P + +H
Sbjct: 588 SNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRH 647
Query: 283 HRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEK-------REDQHQQKQSRDQENHYT-- 333
+ +N E R R R E+ RE + ++++ RD+E
Sbjct: 648 -QGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERE 706
Query: 334 ---------DRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 384
+R+ KERD R R+ H D +R + D+ + R+ RER +R +RE++R
Sbjct: 707 LERERAREREREREKERDRERDRDRDH-DRERERERERDREKERE-REREERERERERER 764
Query: 385 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENND--------KYRD 436
E+ +RE+ER+R + + + E+K K +++ + R+E E+ + K +
Sbjct: 765 ERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKK 824
Query: 437 REKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSL 496
R + E + + R+E SP+S D + + N+ + R QE S S S
Sbjct: 825 RYRNEGSPSPRQSPKRRREHSPDS---DAYNSGDDKNEKHRLLSQVVRPQESRSLSPS-- 879
Query: 497 GAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEE 530
LTE+ Q + KE++R PE K + R EE
Sbjct: 880 ----HLTEDRQGRWKEEDRKPE--RKESSRRYEE 907
Score = 73.9 bits (180), Expect = 4e-13
Identities = 115/593 (19%), Positives = 221/593 (37%), Gaps = 75/593 (12%)
Query: 10 LILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQR----------EAAKKQAMKQTK 59
++ P++++ L P G ++D + ES +R + KQ +
Sbjct: 867 VVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEI 926
Query: 60 LEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKD--RKPKYIHNLLKAVEIRKKE 117
LE + A+D + + + +EN K + K +K K ++ I
Sbjct: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS 986
Query: 118 QEKRM--------EKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAE----EEEREKRA 165
++ ++ +K I+++R+ KG+ D + KKK R +EE +
Sbjct: 987 EDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMC 1046
Query: 166 AALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKN 225
L+ +++K+ + F +E+VP + + G + S
Sbjct: 1047 NGKNGILEDSQKKEDTAF------SDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSL 1100
Query: 226 RIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI------------------EETRVNC 267
P T V A + A S + I E++ C
Sbjct: 1101 LPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKC 1160
Query: 268 RREKV--IETPE---NDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
R +V +ETP D +H + + RS S S R HT G S ++
Sbjct: 1161 HRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDD 1220
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHE--QEDKPRARDQRERSDRVWKR 380
+ R + H RD K + E R KR E + +D R S R
Sbjct: 1221 QSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSP 1280
Query: 381 EKDREKYSQ--------REQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENND 432
E DR+ +S+ R QERDR ++D+ R E+ + ++ ++ + R + D
Sbjct: 1281 ESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNR--DRD 1338
Query: 433 KYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQER---SNKMRNMAK-------DK 482
+ R+RE+ + + +++R+ +S +D+ D++R S+++ ++ + +
Sbjct: 1339 RLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH 1398
Query: 483 ERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSA 535
ER+ E S +L + + G +G E+ E ++E + A
Sbjct: 1399 ERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDA 1451
Score = 72.8 bits (177), Expect = 8e-13
Identities = 73/350 (20%), Positives = 146/350 (41%), Gaps = 26/350 (7%)
Query: 213 KSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKV 272
+ +G ++E+ R + + D + E + D + + + E E R + REK
Sbjct: 646 RHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERER-DREREK- 703
Query: 273 IETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHY 332
E + + R++ R +ER R +RE + +++ R++E
Sbjct: 704 ----ERELERERAREREREREKERDRERDRDRDHDR----ERERERERDREKEREREREE 755
Query: 333 TDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQ 392
+R+ +ER+ R RE +R + DK R R QR+ D+ R+ REK + +
Sbjct: 756 RERERERERERERERERER-----ERARERDKERER-QRDWEDKDKGRDDRREKREEIRE 809
Query: 393 ERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYR---DREKREVGVQSSER 449
+R+ + R S+K + E S + + K R+E ++D Y D+ ++ + R
Sbjct: 810 DRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVR 869
Query: 450 NQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEK 509
Q+ + SP+ L ++R + + + ER + E L K ++ +E+
Sbjct: 870 PQESRSLSPS------HLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQ 923
Query: 510 GKEQERP-PEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 558
+ E A +E+ S R ++ A++ K +K++D
Sbjct: 924 TEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKED 973
Score = 69.3 bits (168), Expect = 9e-12
Identities = 100/538 (18%), Positives = 206/538 (38%), Gaps = 72/538 (13%)
Query: 42 SESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKP 101
S +++E+++ + ++ ++I K ++ E +++ E + +N D
Sbjct: 109 SSPVRKESSRGRHREKEDIKITKERTPES---EEENVEWETNRDDSDNG-------DINY 158
Query: 102 KYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERA---EE 158
Y+H L ++E+++++ ++ + K+++E ++ E K+ + KL +
Sbjct: 159 DYVHEL--SLEMKRQKIQREL-MKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKS 215
Query: 159 EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFS 218
+ KR ++ ++ K + S LL+Q + S + K +G
Sbjct: 216 SKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQ-------------QRNSKTNQSKKKG-P 261
Query: 219 NEVSSKNRIPQE-----------KCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNC 267
S IP++ K + + K + D DF+ + D+ T
Sbjct: 262 RTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAG 321
Query: 268 RREKVIETPENDFKHHRS--------QNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQ 319
+ I + +HH S Q HS SP +R S + + R
Sbjct: 322 QHHSPISS-----RHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPS 376
Query: 320 HQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWK 379
H + +++ R +E+ H H S SH +RHE+ + R + RE+ R +
Sbjct: 377 HSLSSPQRKQSPPRHRSPMREKGRHDHERTSQ--SHDRRHERREDTRGKRDREKDSRE-E 433
Query: 380 REKDREKYSQREQERDRQQND-QNRPSEKGEKEEKSKAKEEHMKVRKE-RYENNDKYRDR 437
RE ++++ S R+ DR+ D ++R + ++ + M+ +E R + D R
Sbjct: 434 REYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESR 493
Query: 438 EKREVGVQSSERNQDRKESSPNSRAKDKFLDQERS--------NKMRNMAKDKERNQEKP 489
+ R+ + +E R +D + ++ RS R +++ RN+ +
Sbjct: 494 DPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRS 553
Query: 490 SNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEE-----TVMSARDRYLAR 542
+G E EKG R + S + N + + RDRY R
Sbjct: 554 EIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPER 611
Score = 65.1 bits (157), Expect = 2e-10
Identities = 83/416 (19%), Positives = 167/416 (40%), Gaps = 53/416 (12%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
R++++E+ +++ +RERE E+ +KE ++ +ERA E ERE+ E D
Sbjct: 677 RERDRERERDRERERERERERDREREKE-------RELERERARERERER-----EKERD 724
Query: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCI 233
+ +D R + E E + RE +EE+ R E + +E+
Sbjct: 725 RERDRD-----RDHDRERERERERDREKERERE---REERERERERERERERERERER-- 774
Query: 234 LQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPS 293
+ + ++ + D++ K D+ E R R ++ ++ K + + SPS
Sbjct: 775 -ERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPS 833
Query: 294 EERGHSTRH-HTKGSRTSRGHEKREDQH---------QQKQSRDQENHYTDRDYR-KERD 342
+ R H+ S + + ++H Q+ +S + DR R KE D
Sbjct: 834 PRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEED 893
Query: 343 SHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREK-----YSQREQERDRQ 397
R+ S R ++ E ++K + D++ + + + R + + ++E +
Sbjct: 894 RKPERKESSR--RYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR 951
Query: 398 QNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESS 457
+D+N+ K +K+ K KE+ + + + E E G S + +K+S
Sbjct: 952 AHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS--------EDGQVFSPKKGQKKKSI 1003
Query: 458 PNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSL----GAKHRLTEEGQEK 509
R K K + +K K + P ++ L K+ + E+ Q+K
Sbjct: 1004 EKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKK 1059
Score = 64.3 bits (155), Expect = 3e-10
Identities = 67/289 (23%), Positives = 118/289 (40%), Gaps = 59/289 (20%)
Query: 248 SDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRS-----QNHSRSPSEERGHSTRH 302
S+ A S DD+ R++V+ + D + +S + SR +RG +R
Sbjct: 1210 SNDSAHRSGDDQ-------SGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRS 1262
Query: 303 HTKGSRTSRGHE-KREDQHQQKQSRDQENHYTDRDYRKERDSHRH---REASHRDSH--- 355
+ + SR H +R +Q + + RD +ERD + H RE RD+
Sbjct: 1263 TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQRE 1322
Query: 356 WKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQ-----------NDQNRP 404
W R +D PR RD+ DR+ +RE++RE+ +R+ +R+R++ D++R
Sbjct: 1323 WDRDADKDWPRNRDR----DRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRT 1378
Query: 405 SEKGEKEE----KSKAKEEH-----------MKVRKER----------YENNDKYRDREK 439
E + E ++K + EH + + KER +E +K E
Sbjct: 1379 FESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTES 1438
Query: 440 REVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEK 488
E G S+ + S + D E + A+ +E Q++
Sbjct: 1439 LEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDE 1487
Score = 46.2 bits (108), Expect = 8e-05
Identities = 58/260 (22%), Positives = 91/260 (35%), Gaps = 39/260 (15%)
Query: 285 SQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSH 344
S N+ RSP G R KR+D + Q R+ E + R H
Sbjct: 71 SSNYRRSPERPTG---------DLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRH 121
Query: 345 RHREASHRDSHWKRHEQEDKPRARDQRERSD---------RVWKREKDREKYSQREQERD 395
R +E +E+ R+ SD E R+K QRE +
Sbjct: 122 REKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKI-QRELMKL 180
Query: 396 RQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKE 455
Q+N + R EE KE +V + + + R K S + + K+
Sbjct: 181 EQENMEKR-------EEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKK 233
Query: 456 SSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPS--NSESSLGAKHR-----------L 502
S LDQ+R++K K R P + +LG K++
Sbjct: 234 DRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEK 293
Query: 503 TEEGQEKGKEQERPPEAVSK 522
T +G+++G++ ER E K
Sbjct: 294 TRDGKDRGRDFERQREKRDK 313
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 104 bits (259), Expect = 2e-22
Identities = 110/514 (21%), Positives = 229/514 (44%), Gaps = 63/514 (12%)
Query: 30 GNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAE-DATVYEYDSIYDEMQKKKEE 88
G + +++ E RE K+ ++ +L QK L E + + E + E ++K E
Sbjct: 269 GKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMRE 328
Query: 89 NNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAY 148
K+ ++R + ++ E + ++QE+RM ++ +R RE E+ + ++ +
Sbjct: 329 QEEKMWRQEERLWEQ-EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW---EQ 384
Query: 149 KKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSG 208
++K+QE EREK+ E + E+ K +E
Sbjct: 385 EEKMQEEERIREREKKMREEEETM---------------------REQEEKMQKQEENMW 423
Query: 209 IKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI-EETRVNC 267
+EEK + R+P++K L K++E + + + K +E+ + +
Sbjct: 424 EQEEKEW-------QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 476
Query: 268 RREKVIETPENDFKHH---RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKR-----EDQ 319
R+EK+ E + ++ R Q EER + +K+ E
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKM 536
Query: 320 HQQKQSRDQENHYTDRDYR-KERDSHRHREASHRDSHWKRHEQEDKPRARDQ--RERSDR 376
++K++++QE D++ + +E + R RE R+ EQE+K + +++ RE+ ++
Sbjct: 537 REEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEK 596
Query: 377 VWKREK-----DREKYSQREQERDRQQNDQNRPSEK--GEKEEKSKAKEEHMKVRKERY- 428
+W++E+ + + + Q E+ ++++ D+ + E+ E+EEK + +EE M ++E+
Sbjct: 597 MWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR 656
Query: 429 ENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEK 488
E +K R++E++ G + R Q+ K + + E+ KMR + +EK
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMR------EQEEKMRGQEEKMWGQEEK 710
Query: 489 PSNSESSLGAKHRLTEEGQ----EKGKEQERPPE 518
E + + + E+ + +K K QER PE
Sbjct: 711 MWGQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744
Score = 103 bits (257), Expect = 4e-22
Identities = 106/524 (20%), Positives = 235/524 (44%), Gaps = 27/524 (5%)
Query: 37 DETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEE--NNPKLL 94
++ ++ES + E + KLE K L + +++ +EM +++EE K +
Sbjct: 194 EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQV---QTNTLQEEMWRQEEELREQEKKI 250
Query: 95 LGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQE 154
++ K L+ E + +EQE++M ++ +R RE EK E ++E + +KKL+E
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK-ELREQEKELRE--QKKLRE 307
Query: 155 RAEE-EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEK 213
+ E+ +E+E++ E + ++K R + E+ K +E R ++E+
Sbjct: 308 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 367
Query: 214 SRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI---EETRVNCRRE 270
R + + ++ +++ +Q + ++ E + K ++E +E ++ + E
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIRER-------EKKMREEEETMREQEEKMQKQEE 420
Query: 271 KVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQEN 330
+ E E +++ R E+ + + + ++ E Q+K+ QE
Sbjct: 421 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 480
Query: 331 HYTDRDYRKERDSH-RHREASHRDSHWKRHEQEDKPRARDQRERSDR-VWKREKD--REK 386
D E++ R +E D + EQ+++ R +++R R + +W++E+ EK
Sbjct: 481 MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 387 YSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQS 446
+Q ++++ Q ++ R E+ + EK +EE M +E + + RE+ E +
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 447 SERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEG 506
E+ Q+++E ++K +QE +KM+ + +EK E + + E
Sbjct: 601 EEKMQEQEEKMWEQ--EEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 507 QEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAK 550
+EK +EQE + + K +E M ++ + Q ++ +
Sbjct: 659 EEKMREQEEKMQGQEE--KMREQEEKMQGQEEKMREQEEKMRGQ 700
Score = 102 bits (255), Expect = 7e-22
Identities = 106/515 (20%), Positives = 226/515 (43%), Gaps = 45/515 (8%)
Query: 37 DETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLG 96
+ ++S L R + +K+ E+Q+ L +S E+Q +E KL
Sbjct: 167 ERDALSLELYRNTITNEELKKKNAELQEKLRLA------ESEKSEIQLNVKELKRKLERA 220
Query: 97 KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQRERE-MEKGEFDDKEAFVTSAYKKKLQER 155
K P+ N L+ R++E+ + EKKI+++ E M + E +E + K++E+
Sbjct: 221 KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ------EGKMREQ 274
Query: 156 AEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSR 215
E+ R+++ ++K+L + L Q E+ + +E + +EEK R
Sbjct: 275 EEKMRRQEKRLR-------EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMR 327
Query: 216 GFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIET 275
++ QE+ + + + ++ E D + + DE R+ + E++ E
Sbjct: 328 EQEEKMWR-----QEERLWEQEKQMREQEQKMRDQEERMWEQDE----RLREKEERMREQ 378
Query: 276 PENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDR 335
+ + + Q R E+ T + + ++ E+ +Q++ Q+ ++
Sbjct: 379 EKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 438
Query: 336 DYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE---RSDRVWKREKDREK----YS 388
KE+ + + + W EQE+K RDQ E + ++W++EK RE+ +
Sbjct: 439 ---KEKLWEQEKMQEQEEKIW---EQEEK--IRDQEEMWGQEKKMWRQEKMREQEDQMWE 490
Query: 389 QREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSE 448
Q E+ RD++Q ++ E++E+ + KEE M+ +K+ ++ +K R+ +K + + +
Sbjct: 491 QEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550
Query: 449 RNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQE 508
+++ R ++K + +E MR + + +EK E + + +E +E
Sbjct: 551 DQEEKMREEERMREREKKM-REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 609
Query: 509 KGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQ 543
K EQE + K +E +M ++ + Q
Sbjct: 610 KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 102 bits (254), Expect = 9e-22
Identities = 105/498 (21%), Positives = 224/498 (44%), Gaps = 40/498 (8%)
Query: 80 DEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDD 139
+E Q+++ E ++ ++ K K + +KE+EK E++ QR+RE+++ E +
Sbjct: 224 EEKQQQRRERQDRVFQEEEEK-----EWRKRETVLRKEEEKLQEEEPQRQRELQEEE-EQ 277
Query: 140 KEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPK 199
+++ QE ++++R +R L + ++++ R + +EE +
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQE-EERREQQEERREQQERREQQEERRE 336
Query: 200 CSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDE 259
R + +E++ R E + ++ +E Q + + E+ + + E
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRRE----QEEERREQQLRREQQLRREQQLRRE 392
Query: 260 IEETRVN-CRREKVIETPENDFKHH--RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKR 316
+ R RRE+ + + + R + R EE H +H + E+
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 317 EDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDR 376
E + K+ + E H +R +++ R +E R+ W + E+E++ R+Q+ER ++
Sbjct: 453 ERRDWLKREEETERHEQER---RKQQLKRDQEEERRE-RWLKLEEEER---REQQERREQ 505
Query: 377 VWKREKD--REKYSQREQERDRQQ----NDQNRPSEKGEKEEKSKAKEEHMKVRKERYEN 430
+RE++ RE+ +R++E +R Q ++Q E+ E+ E+ +EE ++ +ER E
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 431 NDKYRDREKR-EVGVQSSERNQDRKESSPNSRAKDKF-------LDQE--RSNKMRNMAK 480
K E+R ++ + ER Q R + R + + L+QE R +++
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625
Query: 481 DKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYL 540
++ER Q+ + E + +L E QE+ +++ + E + +R E R++ L
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685
Query: 541 A---RQMARVNAKTYIEK 555
A ++ AR K+ I K
Sbjct: 686 AEEEQEQARERIKSRIPK 703
Score = 101 bits (251), Expect = 2e-21
Identities = 104/525 (19%), Positives = 215/525 (40%), Gaps = 87/525 (16%)
Query: 82 MQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKE 141
+Q +++E + + +DR ++ ++ ++R +K+ ++ERE+ +GE ++
Sbjct: 110 LQDRRQEEDQRRFEPRDR------------QLEEEPGQRRRQKRQEQERELAEGEEQSEK 157
Query: 142 AFVTSAYKKKLQERAEE--------EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVG 193
++ Q R EE +ERE+R A +++ L H +
Sbjct: 158 Q--ERLEQRDRQRRDEELWRQRQEWQEREERRA---------EEEQLQSCKGHETEEFPD 206
Query: 194 EEEVPKCSFREARSGIKEEK--------SRGFSNEVSSKNRIPQEKCILQTDVKVEENPD 245
EE++ + E R +EEK R F E + R + + + EE P
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 246 ADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTK 305
+ + ++E R RRE+ E + Q + E R +
Sbjct: 267 RQRELQEEEEQLRKLE--RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 306 GSRTSRGHEKREDQ--------HQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWK 357
R + E+RE Q +Q+ R+QE ++ R+E++ R + R+ +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 358 RHEQ--------------------EDKPRARDQRERSDRVWKREKDREKYSQREQERDRQ 397
R +Q ++ R+Q+ R ++ +RE++ E++ Q+ ++ R+
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 398 QNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESS 457
Q + E+ + ++ + E H + R+++ D+ +R +R + ++ ER + ++
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504
Query: 458 PNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSL-----GAKHRLTEEGQEKGKE 512
R +QE + R +++E ++ SE L + +L + +EK E
Sbjct: 505 QQLRR-----EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 513 QERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKED 557
QER + + KR EE RD+ L R+ R + E+E+
Sbjct: 560 QERREQRL----KREQEE----RRDQLLKREEERRQQRLKREQEE 596
Score = 96.7 bits (239), Expect = 5e-20
Identities = 87/486 (17%), Positives = 211/486 (43%), Gaps = 33/486 (6%)
Query: 46 QREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIH 105
Q E K+ ++T L ++ ++ + +E ++ ++ +L + + +
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 106 NLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRA 165
L + ++R+K++E+R E++ +R + E+ E ++ +++ Q R E+EER ++
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEE--------RREQQLRREQEERREQQ 350
Query: 166 AALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKN 225
E + +Q+ L + EE + RE + ++ E+ ++ +
Sbjct: 351 LRREQEEERREQQ---------LRREQEEERREQQLRREQQ--LRREQQLRREQQLRREQ 399
Query: 226 RIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKH--H 283
++ +E+ + + E + ++ E+ RRE+ ++ + + +
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 284 RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDS 343
R + R E R + + R R + E++ +++Q R ++ +++ R+E+
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 344 HRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNR 403
R E + +Q R+Q ER +++ KRE+++ +R ++R +++ ++ R
Sbjct: 520 KRQEEEERLQQRLRSEQQ----LRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Query: 404 PSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAK 463
+EE+ ++++E+ E ++ RE+ E Q R Q K P +
Sbjct: 576 DQLLKREEER-----RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 464 DKFL---DQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAV 520
+ L +QE + + + +ER +++ E + RL E +E+ +EQE E
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 521 SKFAKR 526
+ +R
Sbjct: 691 EQARER 696
Score = 95.9 bits (237), Expect = 9e-20
Identities = 123/533 (23%), Positives = 227/533 (42%), Gaps = 89/533 (16%)
Query: 35 DDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLL 94
++ E + +R+ KK ++Q + ++ + E + E + Y E ++ ++E L
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ--L 1063
Query: 95 LGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQE 154
LG++R+ + L + + RK+E+ ++ E+++ RE E EK ++E +++LQ+
Sbjct: 1064 LGEERETRRRQELER--QYRKEEELQQEEEQLLRE-EPEKRRRQERERQCRE--EEELQQ 1118
Query: 155 RAEE---EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKE 211
E+ EEREKR ++++L YR EEEV + E ++E
Sbjct: 1119 EEEQLLREEREKR-----------RRQELERQYRE-------EEEVQQ----EEEQLLRE 1156
Query: 212 EKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREK 271
E + E+ + R +E + + EE + + + ++E++ + R
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD 1216
Query: 272 VIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENH 331
E +D K E + + KG + + + Q + +QS+ H
Sbjct: 1217 --EDQRSDLKWQWEPE-----KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Query: 332 YTDRDYRKERDSHRHREASHRDSHWKRHE-----------------QEDKPRARDQRE-- 372
++R+ R R RD H+ E QE+K R++RE
Sbjct: 1270 LLGEQQERDREQERRRW-QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 373 ----RSDRVWKRE----KDREKYSQREQERDRQ-QNDQNRPSEKGEK------------E 411
+DR ++ E ++RE+ R QERDR+ + ++ R E+G K
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388
Query: 412 EKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRK--ESSPNSRAKD---KF 466
E+ KEE +ER + + RDR+ RE Q S + +DRK E R ++ KF
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448
Query: 467 LDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHR----LTEEGQEKGKEQER 515
L++E+ + K +E Q E L + R L EE Q + +E++R
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Score = 94.4 bits (233), Expect = 3e-19
Identities = 112/542 (20%), Positives = 227/542 (41%), Gaps = 48/542 (8%)
Query: 36 DDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLL 95
+ E + L+RE +++ +Q + E ++ E E + E Q ++E+ L
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE-QQLRREQQLRREQQ-----L 395
Query: 96 GKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQER 155
++++ + L + ++R+ EQ+ R E++++RE+E E+ E ++ K++ +ER
Sbjct: 396 RREQQLRREQQLRREQQLRR-EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454
Query: 156 AEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSR 215
+ +RE+ E + KQ+ L + EE RE ++EE+ R
Sbjct: 455 RDWLKREEETERHEQ--ERRKQQ---------LKRDQEEER------RERWLKLEEEERR 497
Query: 216 GFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIET 275
+ R QE+ Q + EE ++ E EE RRE++++
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE-----RREQLLKR 552
Query: 276 PEND-FKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTD 334
E + R + + EER + R R ++E++ +Q+ R++
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 335 RDYRKERDSHRHREASHRDSHWKRHEQEDKPR---ARDQRERSDRVWKREKDREKYSQR- 390
+ R++R E R K EQE++ + R+Q+ER ++ KRE++ E+ QR
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 391 ---EQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV--- 444
+E R+Q E+ + KS+ + ++ E K R +++ G
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 445 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 504
Q E + R+ES + +++ Q++ + R + + +EK L A+ L E
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 505 EGQEKGKEQER--------PPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKE 556
+ + + + +ER P E + +R E + Q+ R +++E
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 557 DD 558
+D
Sbjct: 853 ED 854
Score = 89.4 bits (220), Expect = 8e-18
Identities = 103/543 (18%), Positives = 239/543 (44%), Gaps = 40/543 (7%)
Query: 43 ESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPK 102
E L++E ++Q +K+ + E ++ + + + +++++++E + L ++ + +
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 103 YIHNLLKAVEIRKKEQE----------KRMEKKIQREREMEKGEFDDKEAFVTSAYKKKL 152
L + E ++EQE +R++ +I + + + E D +++ V S +K+
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 153 QERAEEEEREKRAAALEACLD------VTKQKDLSGFYRHLLNQAVGEEEVPKCSFR-EA 205
+R +E+ EKR E+ L +Q+ R Q EE+ + R A
Sbjct: 728 GQRRRQEQEEKRRRR-ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 206 RSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRV 265
R ++E++ R ++ ++ R +E+ L + + E+ + + + +E E+ +
Sbjct: 787 RPPLREQRER----QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ- 841
Query: 266 NCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQS 325
RRE+ + E + Q RS + R R + R R H Q+Q
Sbjct: 842 --RRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 326 RDQENHYTDRD---YRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREK 382
R ++ + + R+ER+ R +E + ++ +QE++ R++RE+ R +E+
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR---QER 956
Query: 383 DREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERY---ENNDKYRDREK 439
+R+ ++ ++ +Q P ++ +E + K +EE ++E E +K R +E
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 440 REVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKER---NQEKPSNSESSL 496
+ E Q+ ++ R K + ++ER + + +E +E+ + L
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 497 GAKHRLTEEGQEKGKE--QERPPEAVSKFAKRN-NEETVMSARDRYLARQMARVNAKTYI 553
++R EE Q++ ++ +E P + + +R EE + + L R+ + +
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 554 EKE 556
E++
Sbjct: 1137 ERQ 1139
Score = 87.0 bits (214), Expect = 4e-17
Identities = 112/550 (20%), Positives = 236/550 (42%), Gaps = 62/550 (11%)
Query: 34 DDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKL 93
++++ E L RE +K+ ++ +LE Q E+ E + +E +K++ + +
Sbjct: 1112 EEEELQQEEEQLLREEREKR--RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ 1169
Query: 94 LLGKDRKPKYIHNLLKAVEIRKKEQEKRM---EKKIQREREMEKGEFDDKEAFVTSAYKK 150
++ + LL+ + +++++ +R E+++QR++ ++ +D+ + + ++
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Query: 151 KLQERAEE--------EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVG---EEEVPK 199
+ + + E + R D Q+DL +HLL + E+E +
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDL----QHLLGEQQERDREQERRR 1285
Query: 200 CSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDE 259
R+ +E+ R E ++R QE+ L + + E+ ++D +
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE----- 1340
Query: 260 IEETRVNCRREKVIETPENDFK------HHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH 313
EE + R E+ + E D K H+ Q E+R K + +
Sbjct: 1341 -EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 314 EKREDQHQQKQSRDQE---------NHYTDRDYRKERDSHRHREASHR---DSHWKRHEQ 361
+E + Q +Q RD++ DR +R+E R +E + + R E+
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 362 EDKPRARDQ--RERSDR-VWKREKDR----EKYSQREQERDRQQNDQNRPSEKGEKEEKS 414
K R +Q +ER ++ + ++E+DR E+ R QERDR+ +Q S++ E++
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 415 KAKEEHMKVRKERY-ENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSN 473
+ ++ H + R+ ++ + + R +E+ + Q +R +E R + + QER
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDR 1579
Query: 474 KMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVM 533
K R + + K R QE+ R +EGQ++ ++ E KF R +E+ +
Sbjct: 1580 KFR-LEEQKVRRQEQERKFMEDEQQLRR--QEGQQQLRQ-----ERDRKF--REDEQLLQ 1629
Query: 534 SARDRYLARQ 543
++ L RQ
Sbjct: 1630 EREEQQLHRQ 1639
Score = 87.0 bits (214), Expect = 4e-17
Identities = 112/546 (20%), Positives = 217/546 (39%), Gaps = 67/546 (12%)
Query: 43 ESLQREAAKKQAMKQTKLEIQKALA-----EDATVYEYDSIYDEMQKKKEENNPKLLLGK 97
E L+RE K+ + K + +K L E E D + E ++ +E + L +
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 98 DRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAE 157
+R K+ + E+R +EQ ++ ++ QR R E+ + F+ + + QER +
Sbjct: 1357 ERDRKF-----REEELRHQEQGRKFLEEEQRLRRQER-----ERKFLKEEQQLRCQEREQ 1406
Query: 158 EEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGF 217
+ +++ E +++Q+ F Q V +E + F E +++E+ R F
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREE--EQQVRRQERER-KFLEEEQQLRQERHRKF 1463
Query: 218 SNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPE 277
E E+ + + + + + D F + E R +E + PE
Sbjct: 1464 REE---------EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514
Query: 278 NDFKHHRSQNHSRSPS------------EERGHSTRHHT--KGSRTSRGHEKREDQHQQK 323
F Q H + +ERG R K + ++RE+Q +
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574
Query: 324 QSRD--------------QENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARD 369
Q RD QE + + + + R + + RD ++ EQ + R
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 370 Q--RERSDRVWKREKDREKYSQREQ----ERDRQQNDQNRPSEKGEKEEKSKAKEEHMKV 423
Q R+ DR + E+ + + +REQ +RDR+ ++ + ++GE E++ + +E K
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE-EQQLRRQERDRKF 1693
Query: 424 RKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKE 483
R+E E + ++RE++ + + R Q+ + + +QE+ + K E
Sbjct: 1694 REE--EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 484 RNQEKPSNSESSLGAKHR---LTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYL 540
Q +P E L + R EE Q + + +E+ + K EE + R+
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 541 ARQMAR 546
R R
Sbjct: 1812 LRPQQR 1817
Score = 83.2 bits (204), Expect = 6e-16
Identities = 109/544 (20%), Positives = 229/544 (42%), Gaps = 52/544 (9%)
Query: 35 DDDETSVSESLQREAAKKQAMKQTKLEI------QKALAEDATVYEYDSIYD------EM 82
D+D+ S Q E K+ A++ K+ Q ED+ + + S D E
Sbjct: 1216 DEDQRS-DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 83 QKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEA 142
Q++ E + +DR L E ++++ KR ++K Q E+++ + E ++K
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQL----EREEQKEAKRRDRKSQEEKQLLREEREEKRR 1330
Query: 143 FVTSAYKKK-----LQERAEE----EEREKRAAALEACLDVTKQKDLSGFYRHLLNQA-- 191
+ K + LQER E+ +ER+++ E +K L R +
Sbjct: 1331 RQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390
Query: 192 --VGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSD 249
+ EE+ +C RE + +++++ R F E +R +++ + + +V
Sbjct: 1391 KFLKEEQQLRCQEREQQ--LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448
Query: 250 FDAKSSADDEI------EETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHH 303
+ + E EE + R E+ + E D K + R +ER R
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR--QERDRKFREQ 1506
Query: 304 TKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQED 363
S+ E+Q +Q R ++ ++ R++ + R+ RD ++ EQ
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ--DRDRKFREEEQLR 1564
Query: 364 KPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGE---KEEKSKAKEEH 420
+ R Q R +R K + +K ++EQER +++Q ++G+ ++E+ + E
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624
Query: 421 MKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNS-----RAKDKFLDQERSNKM 475
++ +ER E ++R+++ + + R Q+R++ + R +++ L + ++
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 476 RNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSA 535
R +D++ +E+ K L EE Q + +E ER + ++ E+ +
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKF-LQEEQQLRRQELERKFREEEQL-RQETEQEQLRR 1742
Query: 536 RDRY 539
++RY
Sbjct: 1743 QERY 1746
Score = 82.8 bits (203), Expect = 8e-16
Identities = 94/471 (19%), Positives = 202/471 (42%), Gaps = 33/471 (7%)
Query: 81 EMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGE---- 136
E ++K E +L + RK + LL+ E ++ +++R K ++ E+++ + E
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 137 FDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEE 196
F ++E +K L+E + ++++ L+ + +Q+ G R EE
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE--RGQQRRQDRDRKFREE 1560
Query: 197 VPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKV---EENPDADSDFDAK 253
RE + ++E+ R F E R QE+ ++ + ++ E + D K
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Query: 254 SSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH 313
D+++ + R E+ + E D K + R +ER RH R R
Sbjct: 1621 FREDEQLLQER----EEQQLHRQERDRKFLEEEPQLRR--QEREQQLRHDR--DRKFREE 1672
Query: 314 EKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRER 373
E+ + +++Q R QE DR +R+E R +E ++ QE++ R + ER
Sbjct: 1673 EQLLQEGEEQQLRRQER---DRKFREEEQQLRRQERE------RKFLQEEQQLRRQELER 1723
Query: 374 SDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDK 433
R ++ + + EQE+ R+Q + E+ + + + ++ + R ++ ++
Sbjct: 1724 KFR-----EEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 434 YR-DREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNS 492
R +RE++++ Q S+R +E R + + Q+R K R +++ + +E+
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR-WEEEQLQLEEQEQRL 1837
Query: 493 ESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQ 543
++R E+ + K + E + ++ +E R+ ++ RQ
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Score = 82.4 bits (202), Expect = 1e-15
Identities = 100/494 (20%), Positives = 218/494 (44%), Gaps = 75/494 (15%)
Query: 36 DDETSVSESLQREAAKKQAMKQT---KLEIQKALAEDATVYEYDSIYDEMQKKKEENNPK 92
++E + E +R +++Q Q +LE ++ T+Y ++ ++++K+++
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH-TLYAKPALQEQLRKEQQ----- 904
Query: 93 LLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQRE-REMEKGEFDDKEAFVTSAYKKK 151
LL ++ + E++++E+EKR ++ +R+ RE E+ + ++++ K++
Sbjct: 905 -LLQEEEE-----------ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 152 LQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKE 211
QER + ++K+ +QK+ Q +GEE E R +
Sbjct: 953 RQERERQYRKDKKL----------QQKE---------EQLLGEEP-------EKRRRQER 986
Query: 212 EKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREK 271
EK E+ +E+ +L+ + + + + + K E E+ R ++
Sbjct: 987 EKKYREEEELQQ-----EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 272 VIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENH 331
++ E + +R + + E+ R + R + K E+ Q+++ +E
Sbjct: 1042 RLQERE---RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 332 YTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE-RSDRVWKREKDREKYSQR 390
R +ER E + R E+E + R +R+ R + ++E+++ +
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 391 EQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERN 450
E+ R ++ Q R E+ ++EE+ +EE K R+ER +YR+ E+ +Q +R
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER---ERQYREEEE----LQRQKRK 1211
Query: 451 QDRKESSPNSRAKDKFLDQERSNKMRN---MAKDKERNQ------EKPSNSESSLGAKHR 501
Q ++ S K ++ + E+ N +R+ K +E Q + + +S +H
Sbjct: 1212 QRYRDEDQRSDLKWQW-EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHL 1270
Query: 502 LTEEGQEKGKEQER 515
L E+ QE+ +EQER
Sbjct: 1271 LGEQ-QERDREQER 1283
Score = 77.0 bits (188), Expect = 4e-14
Identities = 101/517 (19%), Positives = 223/517 (43%), Gaps = 62/517 (11%)
Query: 43 ESLQREAAKKQAMKQTKLEIQKALAEDATV--YEYDSIYDEMQKKKEENNPKLLLGKDRK 100
E L +E ++Q +Q + +K L E+ + E D + E + + +E K L +
Sbjct: 1467 EQLLQEREEQQLHRQER--DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL----EE 1520
Query: 101 PKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEE 160
+ +H + + ++EQ+ R +++ Q+ R+ +F ++E +++ +++ +E
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL----RQEREEQQLSRQE 1576
Query: 161 REKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPK---CSFREARSGIKEEKSRGF 217
R+++ E + +Q+ L + G++++ + FRE ++E + +
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 218 SNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPE 277
+ + + +E + + + + + D D F + E EE ++ RR+ E
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL--RRQ------E 1688
Query: 278 NDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDY 337
D K + R +ER + R K ++ Q +Q +QE Y
Sbjct: 1689 RDRKFREEEQQLRR--QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746
Query: 338 RKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDRE---------KYS 388
RK + + R +R EQ+ + + RD++ R + ++E++ + K+
Sbjct: 1747 RKILEEEQLRP--------EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 389 QREQERDRQQNDQNRPSEKGEK----EEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 444
+ EQ R ++ Q RP ++ K EE+ + +E+ ++R+ER + +YR E
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER---DRQYRAEE------ 1849
Query: 445 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 504
Q + + + R+E + +++ QER K+R ++ R Q+K +G ++
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLR---EEHIRRQQKEEQRHRQVG--EIKSQ 1904
Query: 505 EGQEKGKEQERPPEAVSKFAKRNNE--ETVMSARDRY 539
EG+ G+ E + R++ E + R +Y
Sbjct: 1905 EGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQY 1941
Score = 76.3 bits (186), Expect = 7e-14
Identities = 83/414 (20%), Positives = 176/414 (42%), Gaps = 34/414 (8%)
Query: 127 QREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRH 186
QRER++ E +E ++K Q R + EREK LE +++ L R
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE------EEEQLQ---RR 843
Query: 187 LLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQE----KCILQTDVKVEE 242
Q + EEE +E R ++ + + + ++ + + + K LQ ++ E+
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 243 N--PDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST 300
+ + + + +E R E+ ++ E + R E +
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 301 RHHTKGSRTSRGHE--KREDQHQQKQSRDQENHYTDRDY--RKERDSHRHREASHRDSHW 356
+ + G E KR Q ++K+ R++E + + R+ER+ R +E +
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 357 KRHEQEDKPRARDQRERS-----DRVWKREKDREKYSQ------REQERDRQQNDQNRPS 405
+QE++ R++RE+ +R ++ E++ ++ + RE R ++ Q R
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 406 EKGEKEEKSKAKEEHMKVRKERYENNDKYRDR-EKREVGVQSSERNQDRKESSPNSRAKD 464
E+ ++EE+ +EE K R++ E + + ++ E + ER + R++ ++
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 465 KFLDQERSNKMRNMAKDKERNQ-EKPSNSESSLGAKHR--LTEEGQEKGKEQER 515
+ + QE +R + + R + E+ E L + L EE +++ +E+ER
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Score = 75.9 bits (185), Expect = 9e-14
Identities = 88/456 (19%), Positives = 195/456 (42%), Gaps = 42/456 (9%)
Query: 10 LILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAED 69
L+ ++ QQLH ++ F + + + + Q ++ LE ++ L
Sbjct: 1469 LLQEREEQQLHRQ-ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527
Query: 70 ATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVE---IRKKEQEK--RMEK 124
++ + +E Q +++E + +DRK + L + E + ++E+++ R+E+
Sbjct: 1528 QRQRKF--LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 125 KIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFY 184
+ R +E E+ +D++ +++L++ + + RE + ++++ +
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE--------QLLQEREEQQLH 1637
Query: 185 RHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENP 244
R ++ EEE P+ +E ++ ++ R F E E+ + + + +
Sbjct: 1638 RQERDRKFLEEE-PQLRRQEREQQLRHDRDRKFREE---------EQLLQEGEEQQLRRQ 1687
Query: 245 DADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHT 304
+ D F + E R + E+ + E + K + + +E+ +
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 305 KGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHR----EASHRDSHWKRHE 360
K + +RE+Q ++Q RD++ + R+ER+ + R + R+ R E
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRK-FREEEQLRQEREEQQLRSQESDRKFREEEQLRQE 1806
Query: 361 QEDKPRARDQRERSDRVWKREKDREKYSQR-EQERDRQ--QNDQNRPSEKGEKEEKSKAK 417
+E++ QR+ R + + E+ QR QERDRQ +Q EK +EE+ +
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ 1866
Query: 418 EEHMKVRKERYENNDKYRDREKREVGVQSSERNQDR 453
EE K R+E R+R+ RE ++ ++ + R
Sbjct: 1867 EEEQKRRQE--------RERKLREEHIRRQQKEEQR 1894
Score = 73.2 bits (178), Expect = 6e-13
Identities = 70/296 (23%), Positives = 130/296 (43%), Gaps = 25/296 (8%)
Query: 261 EETRVNCR-REKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH-----E 314
EE R C +E +++ + R + R EE G R + E
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 315 KREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERS 374
K+E Q+ + R E + R +ER+ R E + K HE E+ P +Q R
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC--KGHETEEFPD-EEQLRRR 213
Query: 375 DRVWKREKDREKYSQREQERDRQ----QNDQNRPSEKGE---KEEKSKAKEEHMKVRKER 427
+ + R K RE+ +++Q R+RQ Q ++ + K E ++E+ K +EE + ++E
Sbjct: 214 ELLELRRKGREE--KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 428 YENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQE 487
E ++ R E++E+ + E Q ++ + + K ++ER + + +ER ++
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK-QEEERREQQEERREQQERREQ 330
Query: 488 KPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQ 543
+ E L R EE +E+ +E+ E + +R EE R++ L R+
Sbjct: 331 QEERREQQL---RREQEERREQQLRREQEEERREQQLRREQEE---ERREQQLRRE 380
Score = 69.7 bits (169), Expect = 7e-12
Identities = 87/468 (18%), Positives = 192/468 (41%), Gaps = 45/468 (9%)
Query: 81 EMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDK 140
E +++ P L ++R+ + + +E+EK ++ +RERE E +++
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Query: 141 EAFVTSAYKKKLQERAEE-EEREKRAAALEACLDVTKQKDLSGFY---RHLLNQAVGEEE 196
E ++LQE + +E ++R + E D + L RH L +E
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 197 VPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSA 256
R+ + ++EE+ E + R QE+ + + +E + K
Sbjct: 898 ----QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 257 DDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKR 316
+E R++K ++ E + R E++ + + +
Sbjct: 954 ----QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK-----YREEEELQQEEEQLL 1004
Query: 317 EDQHQQKQSRDQENHYTDRD---------YRKERDSHR--HREASHRDSHWKRHEQED-- 363
++ ++++ ++ E Y +D R+ER+ R RE +R+ + E+E
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 364 -KPRARDQRERSDRVWKREKDREKYSQR------EQERDRQQNDQNRPSEKGEKEEKSKA 416
+ R +R+ +R +++E++ ++ ++ E+ R +++ Q R E+ ++EE+
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124
Query: 417 KEEHMKVRKERYENNDKYRDRE---KREVGVQSSERNQDRKESSPNSRAKDKFLDQERSN 473
+EE K R++ E +YR+ E + E + E + R++ +++ L QE
Sbjct: 1125 REEREKRRRQELER--QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 474 KMRNMAKDKERNQEKPSNSESSL---GAKHRLTEEGQEKGKEQERPPE 518
+R + + + +E+ E L K R +E Q + + PE
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230
Score = 63.2 bits (152), Expect = 6e-10
Identities = 45/263 (17%), Positives = 120/263 (45%), Gaps = 23/263 (8%)
Query: 314 EKREDQHQQK-QSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 372
++R+++ Q++ + RD++ R+++ + RE + + ++ E++++ RD++
Sbjct: 112 DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE---EQSEKQERLEQRDRQR 168
Query: 373 RSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENND 432
R + +W++ ++ ++ +R E ++ Q+ + +E+ EE+ + +E RK R E
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 433 KYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQE-----------------RSNKM 475
+ R+R+ R Q E + RK + + ++K ++E ++
Sbjct: 229 QRRERQDRVF--QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 476 RNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSA 535
R +++E+ Q++ + + E QE+ +EQ+ E + ++
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 536 RDRYLARQMARVNAKTYIEKEDD 558
R++ L R+ + + +E +
Sbjct: 347 REQQLRREQEEERREQQLRREQE 369
Score = 46.2 bits (108), Expect = 8e-05
Identities = 43/209 (20%), Positives = 90/209 (43%), Gaps = 40/209 (19%)
Query: 342 DSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQE-------- 393
D + ++S + QE+ R + R+R ++ R+K ++E+E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 394 --------RDRQQNDQN--RPSEKGEKEEKSKAKEEHMKVRK----ERYENNDKYRDREK 439
RDRQ+ D+ R ++ ++ E+ +A+EE ++ K E + + ++ R RE
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 440 REVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRN----MAKDKERNQEKPSNSESS 495
E+ + E Q ++ +D+ +E + R + K++E+ QE+ +
Sbjct: 216 LELRRKGREEKQQQRR-----ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270
Query: 496 LG---------AKHRLTEEGQEKGKEQER 515
L + L E QE+ ++Q+R
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQR 299
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/201 (18%), Positives = 93/201 (46%), Gaps = 13/201 (6%)
Query: 362 EDKPRAR-DQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEH 420
+++ RAR D +E + ++E+D+ ++ R+++ + + Q R ++ +++E+ A+ E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPG-QRRRQKR-QEQERELAEGEE 153
Query: 421 MKVRKERYENNDKYRD-----REKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKM 475
++ER E D+ R R+++E + R ++ + S ++F D+E+ +
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 476 RNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSA 535
+ ++ +EK + R+ +E +E KE + + K ++ EE
Sbjct: 214 ELLELRRKGREEKQQQRRE---RQDRVFQEEEE--KEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 536 RDRYLARQMARVNAKTYIEKE 556
R+ + R + + +E
Sbjct: 269 RELQEEEEQLRKLERQELRRE 289
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 102 bits (253), Expect = 1e-21
Identities = 110/527 (20%), Positives = 234/527 (44%), Gaps = 43/527 (8%)
Query: 37 DETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEE--NNPKLL 94
++ ++ES + E + KLE K L + +++ +EM +++EE K +
Sbjct: 232 EKLPLAESEKSEIQLNVKELKRKLERAKFLLPQV---QTNTLQEEMWRQEEELREQEKKI 288
Query: 95 LGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQE 154
++ K L+ E + +EQE++M ++ +R RE EK E ++E + +K+L+E
Sbjct: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEK-ELREQEKELRE--QKELRE 345
Query: 155 RAEE-EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEK 213
+ E+ +E+E++ E + ++K R + E+ K +E R ++E+
Sbjct: 346 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 405
Query: 214 SRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVI 273
R + + ++ ++ ++ + K++E D + K ++ I E R E+
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE-- 463
Query: 274 ETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQH-----QQKQSRDQ 328
ET + + Q + EE+ + + EK ++Q Q+++ RDQ
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523
Query: 329 ENHY-------TDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKRE 381
E + R++ D +E RD K +QE++ + Q E+ + W +E
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ-EQEKKTWDQE 582
Query: 382 ---------KDREKYSQREQERDRQQNDQNRPSEKG---------EKEEKSKAKEEHMKV 423
++REK + E+E R+Q ++ + E+ E+EEK + +EE M
Sbjct: 583 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
Query: 424 RKER-YENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDK 482
++E+ +E +K ++++ + ++ +E ++K +QE+ K + K
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKK 702
Query: 483 ERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNE 529
+QEK ES + ++ EE + +++E+ E K ++ E
Sbjct: 703 TWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEE 749
Score = 100 bits (248), Expect = 5e-21
Identities = 107/508 (21%), Positives = 228/508 (44%), Gaps = 53/508 (10%)
Query: 30 GNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAE-DATVYEYDSIYDEMQKKKEE 88
G + +++ E RE K+ ++ +L QK L E + + E + E ++K E
Sbjct: 307 GKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE 366
Query: 89 NNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAY 148
K+ ++R + ++ E + ++QE+RM ++ +R RE E+ ++E
Sbjct: 367 QEEKMWRQEERLWEQ-EKQMREQEQKMRDQEERMWEQDERLREKEE-RMREQEKMWEQVE 424
Query: 149 KKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSG 208
K + +++ +E+E++ R D ++ R + EEE + RE
Sbjct: 425 KMREEKKMQEQEKKTR--------DQEEKMQEEERIREREKKMREEEE----TMREQEEK 472
Query: 209 IKEEKSRGFSNEVSS--KNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI-EETRV 265
+++++ + E + R+P++K L K++E + + + K +E+ + +
Sbjct: 473 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 532
Query: 266 NCRREKVIETPENDFKHH---RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
R+EK+ E + ++ R Q EER +++ Q Q+
Sbjct: 533 MWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER-----------------MEKKTQEQE 575
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQR--ERSDRVWKR 380
K++ DQE + +E + R RE R+ EQE+K + ++++ E+ +++W++
Sbjct: 576 KKTWDQE------EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 381 EKDREKYSQR--EQERDRQQNDQNRPSEKGEKEEKSKAKE-EHMKVRKERYENNDKYRDR 437
E+ ++ ++ EQE + ++ ++ E+K K E E M+ +++ E +K ++
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
Query: 438 EKREVGVQSSER---NQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSES 494
EK E Q E+ +Q++ + R ++K + +E MR + + +EK E
Sbjct: 690 EKMEKKTQEQEKKTWDQEKMREEESMREREKKM-REEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 495 SLGAKHRLTEEGQEKGKEQERPPEAVSK 522
+ + E +EK EQ+R PE K
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
Score = 89.0 bits (219), Expect = 1e-17
Identities = 97/514 (18%), Positives = 222/514 (43%), Gaps = 54/514 (10%)
Query: 36 DDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLL 95
D E + E +R K++ M++ Q+ + E + E +KK + K+
Sbjct: 394 DQEERMWEQDERLREKEERMRE-----QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ- 447
Query: 96 GKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQER 155
++ + + ++ E +EQE++M+K+ + E E+ E+ + K+KL E+
Sbjct: 448 -EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL---PEQKEKLWEQ 503
Query: 156 AEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSR 215
+ +E+E++ E + Q+++ G + + Q E+ + +E + +E+K
Sbjct: 504 EKMQEQEEKIWEQEE--KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 216 GFSNEVSSKN------------RIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI--- 260
+ K ++ +E+ + + + K+ E + + + K +E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 261 -------EETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH 313
+E ++ + EK+ E E ++ + E++ H +
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 314 EKR---EDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQ 370
++ E + +K++++QE D++ +E +S R RE R+ EQE+K + +++
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 371 R--ERSDRVWKREKDREKYSQR--EQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKE 426
+ E+ + +W++E+ + ++ EQ+R +Q ++ EK +++EK +EE M+ ++E
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE 801
Query: 427 RYENND-KYRDREKREVGVQSSERNQDRKESSPNSRA---KDKFLDQERS--NKMRNMAK 480
+ + K R +E++ G + Q+ K + ++K QE KM+ +
Sbjct: 802 KMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEE 861
Query: 481 DKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQE 514
+EK E + E +EK + QE
Sbjct: 862 KMREQEEKMRGQEEKM-------REQEEKMRGQE 888
Score = 79.0 bits (193), Expect = 1e-14
Identities = 68/308 (22%), Positives = 133/308 (43%), Gaps = 31/308 (10%)
Query: 218 SNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPE 277
+ E+ KN QEK L K E + A + + + N +E++ E
Sbjct: 220 NEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 279
Query: 278 N---DFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTD 334
K R Q EER + +++ + Q+K+ R+QE
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL-- 337
Query: 335 RDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQER 394
+E+ R +E ++ K EQE+K RE+ +++W++E+ + Q +Q R
Sbjct: 338 ----REQKELREQEEQMQEQEEKMWEQEEK-----MREQEEKMWRQEE--RLWEQEKQMR 386
Query: 395 DRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRK 454
+++Q +++ E++E+ + KEE M+ +++ +E +K R+ +K + Q++K
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ--------EQEKK 438
Query: 455 ESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQE 514
+ +++ +ER KMR + +EK E ++ E +EK +Q+
Sbjct: 439 TRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW-------EQEEKEWQQQ 491
Query: 515 RPPEAVSK 522
R PE K
Sbjct: 492 RLPEQKEK 499
Score = 72.4 bits (176), Expect = 1e-12
Identities = 56/230 (24%), Positives = 114/230 (49%), Gaps = 10/230 (4%)
Query: 315 KREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERS 374
+ E Q+++ R+QE + RK+ + +E R+ K EQE+K +++R R
Sbjct: 271 QEEMWRQEEELREQE-----KKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLRE 325
Query: 375 DRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKER-YENNDK 433
RE+++E Q+E R++++ Q + + E+EEK + +EE M ++ER +E +
Sbjct: 326 QEKELREQEKELREQKEL-REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
Query: 434 YRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSE 493
R++E++ + QD + R +++ E+ KMR K +E+ ++K + E
Sbjct: 385 MREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ-EKKTRDQE 443
Query: 494 SSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQ 543
+ + R+ E ++ +E+E E K K+ EE + ++ +Q
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQ--EENMWEQEEKEWQQQ 491
Score = 68.9 bits (167), Expect = 1e-11
Identities = 85/397 (21%), Positives = 179/397 (45%), Gaps = 35/397 (8%)
Query: 36 DDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKK--KEENNPKL 93
+ E + + + +K+ +Q K+ Q ED + + + D+ QK +EE K
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQ----EDQMWEQEEKMRDQEQKMWDQEERMEKK 570
Query: 94 LLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQ 153
+++K ++ E R +E+EK+M ++ + RE E+ + +E K Q
Sbjct: 571 TQEQEKKTWDQEEKMREEE-RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 154 ERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEK 213
E +E+ EK E + +Q++ + L Q +E++ + + + ++E++
Sbjct: 630 EEKMQEQEEKMWEQEEK---MWEQEEKMWEQQRLPEQ---KEKLWEHEKMQEQEKMQEQE 683
Query: 214 SRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI---EETRVNCRRE 270
+ + E K QEK + EE ++ + + K ++E+ +E ++ + E
Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQEKMREE--ESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 271 KVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQH----QQKQSR 326
K+ E E ++ Q EE+ + + HEK ++Q Q+++ R
Sbjct: 742 KMQEQEEEMWE----QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR 797
Query: 327 DQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE--RSDRVWKREKDR 384
DQE R + + R +E R K QE+K ++++ + +++W +E+
Sbjct: 798 DQEEKM-----RGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKM 852
Query: 385 EKYSQREQERDRQQNDQNRPSEK--GEKEEKSKAKEE 419
E+ Q ++E+ R+Q ++ R E+ E+EEK + +EE
Sbjct: 853 EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 99.4 bits (246), Expect = 8e-21
Identities = 70/264 (26%), Positives = 127/264 (48%), Gaps = 12/264 (4%)
Query: 254 SSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH 313
SS D E+E + R E+ E E + + RS++ R R S H SR+
Sbjct: 289 SSFDRELEREKERQRLER--EAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRK 346
Query: 314 EKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWK----RHEQEDKPRARD 369
R D+ ++++ ++ DRDY KER + R +E K R E E+K D
Sbjct: 347 GDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED 406
Query: 370 QRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYE 429
+ +R R KR+ +EK R + R+R+ ++R G K +S++KE+ K + E E
Sbjct: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAG-KRSRSRSKEKSSKHKNESKE 465
Query: 430 NNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKP 489
++K R R + S E+++ R+ S +++ + +ERS+K R+ + K+++ +
Sbjct: 466 KSNK-RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK-RDHSDSKDQSDKHD 523
Query: 490 SNSESSLGAKHRLTEEGQEKGKEQ 513
S+ + ++E Q K K++
Sbjct: 524 RRRSQSI---EQESQEKQHKNKDE 544
Score = 95.1 bits (235), Expect = 1e-19
Identities = 75/290 (25%), Positives = 135/290 (46%), Gaps = 24/290 (8%)
Query: 251 DAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEER-GHSTRHHTKGSRT 309
D K A++ + V RR + +P RS SRS S R GH + +
Sbjct: 243 DGKEGAEEI--DRHVERRRSR---SPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELER 297
Query: 310 SRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARD 369
+ ++ E + ++++ + + DR + R R R S S ++ ++ D+ R R+
Sbjct: 298 EKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRERE 357
Query: 370 QRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYE 429
+ R R+ D+E+ ++RE+ER+R + +GE EEK +H + + +R
Sbjct: 358 KENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK-----KHKEDKDDRRH 412
Query: 430 NNDKYRD--REKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQE 487
+DK RD +EK+ +S ER + S N+ + + +E+S+K +N +K+K
Sbjct: 413 RDDK-RDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEK----- 466
Query: 488 KPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARD 537
SN S G++ R + EK K++E P + K KR+ + RD
Sbjct: 467 --SNKRSRSGSQGR--TDSVEKSKKREHSP-SKEKSRKRSRSKERSHKRD 511
Score = 72.0 bits (175), Expect = 1e-12
Identities = 62/273 (22%), Positives = 123/273 (45%), Gaps = 22/273 (8%)
Query: 298 HSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYT---DRDYRKERDSHR-HREASHRD 353
H R ++ R S +R + + +S +E H + DR+ +E++ R REA R+
Sbjct: 254 HVERRRSRSPRRSLS-PRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
Query: 354 SHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQR---EQERDRQQNDQNRPSEKGEK 410
+R D+ R + +R R + R++ R ++ER+++ R +K
Sbjct: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
Query: 411 EEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQE 470
E ++ ++E + R+ E + EK+ + R++D K S K+K +
Sbjct: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDS----KKEKKHSRS 428
Query: 471 RSNKMRNMAKDKERNQEKPSNSES-SLGAKHRLTEEGQEKGKEQERP-----PEAVSKFA 524
RS + ++ ++ + RN K S S S +KH+ E +EK ++ R ++V K
Sbjct: 429 RSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK--NESKEKSNKRSRSGSQGRTDSVEKSK 486
Query: 525 KRNNEETVMSARDRYLARQMARVNAKTYIEKED 557
KR + + +R R +R R + + + + +D
Sbjct: 487 KREHSPSKEKSRKR--SRSKERSHKRDHSDSKD 517
Score = 62.8 bits (151), Expect = 8e-10
Identities = 48/219 (21%), Positives = 101/219 (46%), Gaps = 10/219 (4%)
Query: 321 QQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKR 380
QQ ++R ++ ++ +E D H R S + + PR +R RS R R
Sbjct: 231 QQIKTRPRKIKKDGKEGAEEIDRHVERRRS------RSPRRSLSPRRSPRRSRS-RSHHR 283
Query: 381 EKDREKYSQREQERDRQQNDQNRPSEKGEKE-EKSKAKEEHMKVRKERYENNDKYRDREK 439
E RE ER++++ R +++ EKE +S++ + ++ R+ R + R R +
Sbjct: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
Query: 440 REVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAK 499
G +R+++R++ + R +D+ D+ER N+ R +++ R + K S + K
Sbjct: 344 DRKG-DRRDRDREREKENERGRRRDRDYDKERGNE-REKERERSRERSKEQRSRGEVEEK 401
Query: 500 HRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDR 538
++ + ++ +R + K ++ + E +R R
Sbjct: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
Score = 53.1 bits (126), Expect = 6e-07
Identities = 61/313 (19%), Positives = 123/313 (39%), Gaps = 32/313 (10%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
R++ + R +R + +E +S++ ++L+ E + E+ A E
Sbjct: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE---- 312
Query: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCI 233
K++ S L + R +RS + +SR S + R
Sbjct: 313 --KERRRSRSIDRGLER------------RRSRSR-ERHRSRSRSRDRKGDRRDRDR--- 354
Query: 234 LQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPS 293
+ + + E D D+D + + E E R R ++ E + K H+ R
Sbjct: 355 -EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
Query: 294 EERGHSTRH--HTKGSRTSRGHEKR---EDQHQQKQSRDQENHYTDRDYRKERDSHRHRE 348
+++ S + H++ R H R + ++ +SR +E ++ KE+ + R R
Sbjct: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
Query: 349 AS--HRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSE 406
S DS K ++E P R+RS K + +S + + D+ +++ E
Sbjct: 474 GSQGRTDSVEKSKKREHSPSKEKSRKRSRS--KERSHKRDHSDSKDQSDKHDRRRSQSIE 531
Query: 407 KGEKEEKSKAKEE 419
+ +E++ K K+E
Sbjct: 532 QESQEKQHKNKDE 544
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/186 (22%), Positives = 80/186 (43%), Gaps = 9/186 (4%)
Query: 357 KRHEQEDKPRAR----DQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEE 412
K +Q+ K R R D +E ++ + + + R S R R+ ++R +
Sbjct: 227 KNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGH 286
Query: 413 KSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERS 472
S + + ++ KER + ++REK +S +R +R+ SR++++ + RS
Sbjct: 287 GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERR----RSRSRERHRSRSRS 342
Query: 473 NKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETV 532
+ +D++R +EK N + E G E+ KE+ER E + R E
Sbjct: 343 RDRKGDRRDRDREREK-ENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK 401
Query: 533 MSARDR 538
D+
Sbjct: 402 KHKEDK 407
Score = 50.4 bits (119), Expect = 4e-06
Identities = 57/293 (19%), Positives = 126/293 (43%), Gaps = 37/293 (12%)
Query: 42 SESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKP 101
S S RE +++ ++ + E ++ E D + + + E + +DRK
Sbjct: 288 SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347
Query: 102 KYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEER 161
R +E+EK E+ +R+R+ +K +++E K +ER+ E +
Sbjct: 348 DR--------RDRDREREKENERGRRRDRDYDKERGNERE---------KERERSRERSK 390
Query: 162 EKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEV 221
E+R+ ++ K K+ RH ++ ++E K S +R +SR +
Sbjct: 391 EQRS---RGEVEEKKHKEDKDDRRHRDDKRDSKKE-KKHSRSRSRERKHRSRSRSRNAGK 446
Query: 222 SSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFK 281
S++R ++ + + K + N + S ++ D +E+++ + +
Sbjct: 447 RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRT---DSVEKSK------------KREHS 491
Query: 282 HHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTD 334
+ ++ RS S+ER H R H+ S H++R Q +++S+++++ D
Sbjct: 492 PSKEKSRKRSRSKERSHK-RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 96.3 bits (238), Expect = 7e-20
Identities = 107/509 (21%), Positives = 219/509 (43%), Gaps = 24/509 (4%)
Query: 36 DDETSVSESLQREAAKKQAMKQTKLEIQKALAE-DATVYEYDSIYDEMQKKKEENNPKLL 94
+ E S + +E +K + L Q+ AE D E S+ ++Q + EEN
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 95 LGKDRKPKYIHNLLKAVEIRKK--EQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKL 152
L + ++ K K E +K EQE+++ ++ ++ RE E+ +E K +
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 153 QERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEE 212
QE E+ EK E + K++ + + + E+ + + + +EE
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWE--KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 411
Query: 213 KSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI----EETRVNCR 268
K + + R QE + + + K+ E + + + K +E E+ R +
Sbjct: 412 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 471
Query: 269 REKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQ 328
R++ E + K H + R + + + + R EK +Q ++ + +++
Sbjct: 472 RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEE 531
Query: 329 ENHYTDRDYRKERDSHRHREASH-RDSHW---KRHEQEDKPRARDQ--RERSDRVWKREK 382
+ + R++ + R E H ++ W KR EQEDK +++ RE+ ++VW++E
Sbjct: 532 KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE- 590
Query: 383 DREKYSQREQERDRQQNDQNRPSEK-GEKEEKSKAKEEHMKVRKERYENNDKYRDREKRE 441
EK ++E++R Q+ + EK E+EEK + +EE ++ ++E+ ++ ++ +
Sbjct: 591 --EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Query: 442 VGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHR 501
+G Q E +E + + + +E K+R K +EK E + +
Sbjct: 649 MGEQ--EEKMCEQEEKMQEQEETMWRQEE---KIREQEKKIREQEEKIREQEEMMQEQEE 703
Query: 502 LTEEGQEKGKEQERPPEAVSKFAKRNNEE 530
E +EK EQE + + +R E+
Sbjct: 704 KMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732
Score = 83.2 bits (204), Expect = 6e-16
Identities = 108/510 (21%), Positives = 219/510 (42%), Gaps = 30/510 (5%)
Query: 10 LILPKKTQQL---HPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEI--QK 64
L+LP++ Q H + SV +E + L ++ +K ++ K++ +K
Sbjct: 256 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 315
Query: 65 ALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEK 124
++ + E + E Q++K +++ K+ K + ++ E + + QE+ M +
Sbjct: 316 IQEQEEKIREQEEKIRE-QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 374
Query: 125 KIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFY 184
K ++ R E+ ++ +E K QE+ E+E EKR + +Q+ + +
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE-EKRQEEEKIREQEKRQEQEAKMW 433
Query: 185 RHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENP 244
R + + E+E K +E + +EEK + R QE+ Q + K+ E
Sbjct: 434 RQ--EEKIREQE-EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE-KIHEQE 489
Query: 245 DADSDFDAKSSADDEI--EETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRH 302
+ + +++I +E +V + EK+ E E + E+ R
Sbjct: 490 EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWRE 549
Query: 303 HTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQE 362
K + E+ + Q Q+ + QE +++ + R + RE KR EQE
Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEE-----KRQEQE 604
Query: 363 DKPRARDQ--RERSDRVWKREK----DREKYSQREQERDRQQNDQNRPSEK-GEKEEKSK 415
+K +++ RE+ +++ ++E+ EK ++E+ Q+ EK E+EEK +
Sbjct: 605 EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 664
Query: 416 AKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKM 475
+EE M ++E+ +K + RE+ E + E Q+++E ++K +QE KM
Sbjct: 665 EQEETMWRQEEKIREQEK-KIREQEEKIREQEEMMQEQEEKM--WEQEEKMCEQE--EKM 719
Query: 476 RNMAKDKERNQEKPSNSESSLGAKHRLTEE 505
+ + R +EK E L + +E
Sbjct: 720 QEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/293 (24%), Positives = 147/293 (50%), Gaps = 29/293 (9%)
Query: 278 NDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDY 337
N+ K RS++H+RS S S++ H++ R+ H R H + +SR ++ + +
Sbjct: 301 NERKGGRSRSHTRSKSRS---SSKSHSRRKRSQSKHRSRS--HNRSRSRQKDRRRSKSPH 355
Query: 338 RKERDSHRHREASHRD-SHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDR 396
+K S R++ R S KR + +K + +++ + DR EK+RE+ +RE+E++R
Sbjct: 356 KKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR----EKEREREKEREKEKER 411
Query: 397 QQN-DQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKE 455
+N D+++ EK +++K K +E +ER + ++K RD+EK + + ER +DR +
Sbjct: 412 GKNKDRDKEREKDREKDKEKDRE------REREKEHEKDRDKEKEKEQDKEKEREKDRSK 465
Query: 456 SSPNSRAKDKF-----LDQERSNKMRNMAKDKERNQEKPS--NSESSLGAKHRLT----- 503
R KDK S + R+ ++++ R + + S + +S K + +
Sbjct: 466 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525
Query: 504 EEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKE 556
+K K++E+ + +S+ +R ++ + + ++ N+ + EKE
Sbjct: 526 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE 578
Score = 93.6 bits (231), Expect = 4e-19
Identities = 73/263 (27%), Positives = 127/263 (48%), Gaps = 26/263 (9%)
Query: 281 KHH-RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRK 339
KH RS N SRS ++R S H K S++ + R H + + +D +++ K
Sbjct: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391
Query: 340 ERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQN 399
E+D + RE R+ ++ ++ K + RD+ DR +EKDRE+ ++E E+DR +
Sbjct: 392 EKDREKERE---REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK- 447
Query: 400 DQNRPSEKGEKEEKSKAKEEHMKVRKER--------YENNDKYRD--REKREVGVQSSER 449
++ + +K ++ EK ++KE K +K++ Y + + R RE+R +SS R
Sbjct: 448 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 507
Query: 450 NQ------DRKES---SPNSR-AKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAK 499
+ RK S SP SR KDK ++ER + +++ + K SN
Sbjct: 508 SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKL 567
Query: 500 HRLTEEGQEKGKEQERPPEAVSK 522
+ + +EK +E P +VSK
Sbjct: 568 EKNSTSLKEKEHNKE-PDSSVSK 589
Score = 77.8 bits (190), Expect = 2e-14
Identities = 55/271 (20%), Positives = 112/271 (41%), Gaps = 10/271 (3%)
Query: 263 TRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
+R RR + R ++ SRS S ++ TR K + ++ +++ ++
Sbjct: 343 SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE 402
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREK 382
K+ ++ ++D KER+ R ++ +D +R ++ +K R +++ + D+ +REK
Sbjct: 403 KEREKEKERGKNKDRDKEREKDREKD-KEKDREREREKEHEKDRDKEKEKEQDKEKEREK 461
Query: 383 DREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVR-KERYENNDKYRDREKRE 441
DR K ++++D++ R + S + + R R K R+
Sbjct: 462 DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSR 521
Query: 442 VGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHR 501
S +D+K ++ ++ERS MR + D++ ++ NS S
Sbjct: 522 SPSPRSRNKKDKKREKERDHISER-RERERSTSMRKSSNDRDGKEKLEKNSTS------- 573
Query: 502 LTEEGQEKGKEQERPPEAVSKFAKRNNEETV 532
L E+ K + E K A R E +
Sbjct: 574 LKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 604
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/239 (19%), Positives = 106/239 (44%), Gaps = 29/239 (12%)
Query: 252 AKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSR 311
++S + D+ ++TR + ++ ++ E D + R + R +ERG + K R
Sbjct: 369 SRSHSRDKRKDTREKIKEKERVK--EKDREKEREREKEREKEKERGKN-----KDRDKER 421
Query: 312 GHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQR 371
++ +D+ + ++ ++ H DRD KE++ + +E R ++ D+ R +D++
Sbjct: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK-----DRSKEIDEKRKKDKK 476
Query: 372 ERSDRVWKREKDREKYSQREQERDRQQNDQNRPS----------------EKGEKEEKSK 415
R+ R + S RE+ R R ++ P + +K++K +
Sbjct: 477 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
Query: 416 AKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNK 474
+ +H+ R+ER + + R+ G + E+N + +++ D + +E +K
Sbjct: 537 KERDHISERRERERSTSMRKSSNDRD-GKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594
Score = 61.2 bits (147), Expect = 2e-09
Identities = 73/322 (22%), Positives = 131/322 (40%), Gaps = 53/322 (16%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
RK+ Q K + R R +K K S +KK+ + R + R + +
Sbjct: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSK-----SPHKKRSKSRERRKSRSRSHSR------ 374
Query: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCI 233
K+KD R + + +E + RE ++EK RG N+ K R +
Sbjct: 375 -DKRKDT----REKIKEKERVKEKDREKEREREKEREKEKERG-KNKDRDKEREKDREKD 428
Query: 234 LQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHH---RSQNHSR 290
+ D + E + + D D + + + E+ R R +++ E + D K RS N SR
Sbjct: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR 488
Query: 291 ----SPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRH 346
S E R +R ++ RTS+ +++ + +SR+++ D+ KERD
Sbjct: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK----DKKREKERD---- 540
Query: 347 REASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQE----RDRQQNDQN 402
H E R +RERS + K DR+ + E+ ++++ N +
Sbjct: 541 ------------HISE-----RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEP 583
Query: 403 RPSEKGEKEEKSKAKEEHMKVR 424
S E ++K + E K++
Sbjct: 584 DSSVSKEVDDKDAPRTEENKIQ 605
Score = 53.9 bits (128), Expect = 4e-07
Identities = 68/334 (20%), Positives = 132/334 (39%), Gaps = 81/334 (24%)
Query: 97 KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERA 156
K R + + K + KE+E+ EK ++ERE EK +KE K K +++
Sbjct: 366 KSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE-----RGKNKDRDKE 420
Query: 157 EEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRG 216
E++REK K+KD RE + EK R
Sbjct: 421 REKDREK-----------DKEKD-----------------------REREREKEHEKDR- 445
Query: 217 FSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETP 276
E+ + D + + + EI+E R +++K TP
Sbjct: 446 ----------------------DKEKEKEQDKEKEREKDRSKEIDEKR---KKDKKSRTP 480
Query: 277 ENDFK-HHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDR 335
+ RS++ SR E R +R ++ RTS+ +++ + +SR+++ D+
Sbjct: 481 PRSYNASRRSRSSSR---ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK----DK 533
Query: 336 DYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERD 395
KERD R R + ++ + RD +E+ ++ K++E + +
Sbjct: 534 KREKERDHISERRERERSTSMRKSSND-----RDGKEKLEKNSTSLKEKEHNKEPDSSVS 588
Query: 396 RQQNDQNRPSEKGEKEEKS---KAKEEHMKVRKE 426
++ +D++ P + K + + + EE++ + E
Sbjct: 589 KEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 5/155 (3%)
Query: 381 EKDREKYSQREQERDRQQN-DQNRPSEKGEKEEK-SKAKEEHMKVRKERYENNDKYRDRE 438
E + K ++R+ R R ++R S K K S++K + R D+ R +
Sbjct: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353
Query: 439 KREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGA 498
+ +S ER + R S + KD + +++ ++KER +EK E G
Sbjct: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 413
Query: 499 ---KHRLTEEGQEKGKEQERPPEAVSKFAKRNNEE 530
+ + E+ +EK KE++R E + K ++E
Sbjct: 414 NKDRDKEREKDREKDKEKDREREREKEHEKDRDKE 448
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/293 (24%), Positives = 147/293 (50%), Gaps = 29/293 (9%)
Query: 278 NDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDY 337
N+ K RS++H+RS S S++ H++ R+ H R H + +SR ++ + +
Sbjct: 185 NERKGGRSRSHTRSKSRS---SSKSHSRRKRSQSKHRSRS--HNRSRSRQKDRRRSKSPH 239
Query: 338 RKERDSHRHREASHRD-SHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDR 396
+K S R++ R S KR + +K + +++ + DR EK+RE+ +RE+E++R
Sbjct: 240 KKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR----EKEREREKEREKEKER 295
Query: 397 QQN-DQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKE 455
+N D+++ EK +++K K +E +ER + ++K RD+EK + + ER +DR +
Sbjct: 296 GKNKDRDKEREKDREKDKEKDRE------REREKEHEKDRDKEKEKEQDKEKEREKDRSK 349
Query: 456 SSPNSRAKDKF-----LDQERSNKMRNMAKDKERNQEKPS--NSESSLGAKHRLT----- 503
R KDK S + R+ ++++ R + + S + +S K + +
Sbjct: 350 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 409
Query: 504 EEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKE 556
+K K++E+ + +S+ +R ++ + + ++ N+ + EKE
Sbjct: 410 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE 462
Score = 93.6 bits (231), Expect = 4e-19
Identities = 73/263 (27%), Positives = 127/263 (48%), Gaps = 26/263 (9%)
Query: 281 KHH-RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRK 339
KH RS N SRS ++R S H K S++ + R H + + +D +++ K
Sbjct: 216 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 275
Query: 340 ERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQN 399
E+D + RE R+ ++ ++ K + RD+ DR +EKDRE+ ++E E+DR +
Sbjct: 276 EKDREKERE---REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK- 331
Query: 400 DQNRPSEKGEKEEKSKAKEEHMKVRKER--------YENNDKYRD--REKREVGVQSSER 449
++ + +K ++ EK ++KE K +K++ Y + + R RE+R +SS R
Sbjct: 332 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 391
Query: 450 NQ------DRKES---SPNSR-AKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAK 499
+ RK S SP SR KDK ++ER + +++ + K SN
Sbjct: 392 SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKL 451
Query: 500 HRLTEEGQEKGKEQERPPEAVSK 522
+ + +EK +E P +VSK
Sbjct: 452 EKNSTSLKEKEHNKE-PDSSVSK 473
Score = 77.8 bits (190), Expect = 2e-14
Identities = 55/271 (20%), Positives = 112/271 (41%), Gaps = 10/271 (3%)
Query: 263 TRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
+R RR + R ++ SRS S ++ TR K + ++ +++ ++
Sbjct: 227 SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE 286
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREK 382
K+ ++ ++D KER+ R ++ +D +R ++ +K R +++ + D+ +REK
Sbjct: 287 KEREKEKERGKNKDRDKEREKDREKD-KEKDREREREKEHEKDRDKEKEKEQDKEKEREK 345
Query: 383 DREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVR-KERYENNDKYRDREKRE 441
DR K ++++D++ R + S + + R R K R+
Sbjct: 346 DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSR 405
Query: 442 VGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHR 501
S +D+K ++ ++ERS MR + D++ ++ NS S
Sbjct: 406 SPSPRSRNKKDKKREKERDHISER-RERERSTSMRKSSNDRDGKEKLEKNSTS------- 457
Query: 502 LTEEGQEKGKEQERPPEAVSKFAKRNNEETV 532
L E+ K + E K A R E +
Sbjct: 458 LKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 488
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/239 (19%), Positives = 106/239 (44%), Gaps = 29/239 (12%)
Query: 252 AKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSR 311
++S + D+ ++TR + ++ ++ E D + R + R +ERG + K R
Sbjct: 253 SRSHSRDKRKDTREKIKEKERVK--EKDREKEREREKEREKEKERGKN-----KDRDKER 305
Query: 312 GHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQR 371
++ +D+ + ++ ++ H DRD KE++ + +E R ++ D+ R +D++
Sbjct: 306 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK-----DRSKEIDEKRKKDKK 360
Query: 372 ERSDRVWKREKDREKYSQREQERDRQQNDQNRPS----------------EKGEKEEKSK 415
R+ R + S RE+ R R ++ P + +K++K +
Sbjct: 361 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 420
Query: 416 AKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNK 474
+ +H+ R+ER + + R+ G + E+N + +++ D + +E +K
Sbjct: 421 KERDHISERRERERSTSMRKSSNDRD-GKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 478
Score = 61.2 bits (147), Expect = 2e-09
Identities = 73/322 (22%), Positives = 131/322 (40%), Gaps = 53/322 (16%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
RK+ Q K + R R +K K S +KK+ + R + R + +
Sbjct: 210 RKRSQSKHRSRSHNRSRSRQKDRRRSK-----SPHKKRSKSRERRKSRSRSHSR------ 258
Query: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCI 233
K+KD R + + +E + RE ++EK RG N+ K R +
Sbjct: 259 -DKRKDT----REKIKEKERVKEKDREKEREREKEREKEKERG-KNKDRDKEREKDREKD 312
Query: 234 LQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHH---RSQNHSR 290
+ D + E + + D D + + + E+ R R +++ E + D K RS N SR
Sbjct: 313 KEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR 372
Query: 291 ----SPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRH 346
S E R +R ++ RTS+ +++ + +SR+++ D+ KERD
Sbjct: 373 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK----DKKREKERD---- 424
Query: 347 REASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQE----RDRQQNDQN 402
H E R +RERS + K DR+ + E+ ++++ N +
Sbjct: 425 ------------HISE-----RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEP 467
Query: 403 RPSEKGEKEEKSKAKEEHMKVR 424
S E ++K + E K++
Sbjct: 468 DSSVSKEVDDKDAPRTEENKIQ 489
Score = 53.9 bits (128), Expect = 4e-07
Identities = 68/334 (20%), Positives = 132/334 (39%), Gaps = 81/334 (24%)
Query: 97 KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERA 156
K R + + K + KE+E+ EK ++ERE EK +KE K K +++
Sbjct: 250 KSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE-----RGKNKDRDKE 304
Query: 157 EEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRG 216
E++REK K+KD RE + EK R
Sbjct: 305 REKDREK-----------DKEKD-----------------------REREREKEHEKDR- 329
Query: 217 FSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETP 276
E+ + D + + + EI+E R +++K TP
Sbjct: 330 ----------------------DKEKEKEQDKEKEREKDRSKEIDEKR---KKDKKSRTP 364
Query: 277 ENDFK-HHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDR 335
+ RS++ SR E R +R ++ RTS+ +++ + +SR+++ D+
Sbjct: 365 PRSYNASRRSRSSSR---ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK----DK 417
Query: 336 DYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERD 395
KERD R R + ++ + RD +E+ ++ K++E + +
Sbjct: 418 KREKERDHISERRERERSTSMRKSSND-----RDGKEKLEKNSTSLKEKEHNKEPDSSVS 472
Query: 396 RQQNDQNRPSEKGEKEEKS---KAKEEHMKVRKE 426
++ +D++ P + K + + + EE++ + E
Sbjct: 473 KEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 506
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 5/155 (3%)
Query: 381 EKDREKYSQREQERDRQQN-DQNRPSEKGEKEEK-SKAKEEHMKVRKERYENNDKYRDRE 438
E + K ++R+ R R ++R S K K S++K + R D+ R +
Sbjct: 178 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 237
Query: 439 KREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGA 498
+ +S ER + R S + KD + +++ ++KER +EK E G
Sbjct: 238 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 297
Query: 499 ---KHRLTEEGQEKGKEQERPPEAVSKFAKRNNEE 530
+ + E+ +EK KE++R E + K ++E
Sbjct: 298 NKDRDKEREKDREKDKEKDREREREKEHEKDRDKE 332
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 93.2 bits (230), Expect = 6e-19
Identities = 58/217 (26%), Positives = 112/217 (51%), Gaps = 6/217 (2%)
Query: 313 HEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRE 372
H+K E++ +K+ QE R+ +ER+ R R R+ +R +++K R R++
Sbjct: 288 HKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERER 347
Query: 373 RSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENND 432
DR +E+DR++ +R+++RDR+++ +R ++ EKS+ +E + +ER +
Sbjct: 348 DRDRDRTKERDRDRDRERDRDRDRERS-SDRNKDRSRSREKSRDRERERERERERERERE 406
Query: 433 KYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNS 492
+ R+RE+ + ER ++R++ R +D+ ER R + + + QE+ N
Sbjct: 407 RERERERER--EREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNW 464
Query: 493 ESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNE 529
E K R E+ E+ +E+ R ++K AKR E
Sbjct: 465 EIRERKKTREYEKEAEREEERRR---EMAKEAKRLKE 498
Score = 87.4 bits (215), Expect = 3e-17
Identities = 73/255 (28%), Positives = 124/255 (48%), Gaps = 21/255 (8%)
Query: 294 EERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASH-R 352
EE+G + + + R E+ ++ ++++ R++E +R+ KE++ R RE R
Sbjct: 293 EEKGKKEKERQEIEKERRERERERERERERRERERERE-REREREKEKERERERERDRDR 351
Query: 353 DSHWKRHEQEDKPRARDQ-RER-SDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEK 410
D +R D+ R RD+ RER SDR R + REK RE+ER+R+ R E+ +
Sbjct: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERE-----RERERERE 406
Query: 411 EEKSKAKEEHMKVRKERYENNDKYRDREKREVGV---QSSERNQDRKESSPNSRAKDKFL 467
E+ + +E + +ER DK RDRE+ E + ER KE++ R K+ +
Sbjct: 407 REREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEI 466
Query: 468 DQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPP----EAVSKF 523
+ + K R K+ ER +E+ E + AK RL E ++ +++ P A+ K
Sbjct: 467 RERK--KTREYEKEAEREEER--RREMAKEAK-RLKEFLEDYDDDRDDPKYYRGSALQKR 521
Query: 524 AKRNNEETVMSARDR 538
+ +E RDR
Sbjct: 522 LRDREKEMEADERDR 536
Score = 85.5 bits (210), Expect = 1e-16
Identities = 97/480 (20%), Positives = 195/480 (40%), Gaps = 90/480 (18%)
Query: 80 DEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDD 139
DE + KK+ +N + +P+ + N + E+ ++++ +R +M KG +
Sbjct: 170 DEWKAKKKASNG------NARPETVTN----------DDEEALDEETKRRDQMIKGAIE- 212
Query: 140 KEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPK 199
+ Y +L ++E + R E D+ ++ ++ + L + +E++
Sbjct: 213 ---VLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPL---ITKEDINA 266
Query: 200 CSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDE 259
++E+K S E+S T K+EE K E
Sbjct: 267 IE-------MEEDKRDLISREISK---------FRDTHKKLEEEKGK------KEKERQE 304
Query: 260 IEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQ 319
IE+ R RE+ E + + R + R +ER R E+ D+
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKER-------------ERERERDRDR 351
Query: 320 HQQKQSRDQENHYTDRDYRKERDSHRHREASH-RDSHWKRHEQEDKPRARDQRERSDRVW 378
+ K+ + DRD +ER S R+++ S R+ R + ++ R R++ +R
Sbjct: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERER 411
Query: 379 KREKDREKYSQREQERDR---QQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYR 435
+RE++RE+ +RE+E+D+ ++ D+ E+ + E K + KE + R + +E ++ +
Sbjct: 412 EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKK 471
Query: 436 DREKREVGVQSSERNQDRKESSPNSRAKDKFLDQ----------ERSNKMRNMAKDKERN 485
RE + + ER R+E + ++ +FL+ R + ++ +D+E+
Sbjct: 472 TREYEKEAEREEER---RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKE 528
Query: 486 QE-----KPSNSESSLGAKHRLTEEG----------QEKGKEQERPPEAVSKFAKRNNEE 530
E + E + RL EG E+ E+ R P+ + EE
Sbjct: 529 MEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEE 588
Score = 81.6 bits (200), Expect = 2e-15
Identities = 83/363 (22%), Positives = 158/363 (43%), Gaps = 38/363 (10%)
Query: 226 RIPQEKCILQTDVKVEENPDADSDFDAKSSA------------DDEIEETRVNCRREKVI 273
+I ++K +++ D K + D ++ AK A DDE RR+++I
Sbjct: 151 QIGEKKLLVKVDAKTKAQLD---EWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMI 207
Query: 274 E----------TPENDFKHHRSQNHSRSPSEERGHST-RHHTKGSRTSRGHEKREDQHQQ 322
+ + E + S +H R +E+ R +ED +
Sbjct: 208 KGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAI 267
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARD-QRERSDRVWKRE 381
+ D+ + R+ K RD+H+ E +R E E + R R+ +RER +RE
Sbjct: 268 EMEEDKRD-LISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERE 326
Query: 382 KDREKYSQREQERDRQ---QNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDRE 438
++RE+ +RE+E++R+ + D++R K ++ + ++ + N D+ R RE
Sbjct: 327 REREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386
Query: 439 KREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGA 498
K + ER ++R+ R +++ ++ER + R KDK+R++E+ E
Sbjct: 387 KSRDRERERERERERERERERERERERERERERERE-REREKDKKRDREE---DEEDAYE 442
Query: 499 KHRLTEEGQEK-GKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMAR--VNAKTYIEK 555
+ +L + +EK QER + K+ E + R+ R+MA+ K ++E
Sbjct: 443 RRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLED 502
Query: 556 EDD 558
DD
Sbjct: 503 YDD 505
Score = 65.5 bits (158), Expect = 1e-10
Identities = 99/470 (21%), Positives = 180/470 (38%), Gaps = 60/470 (12%)
Query: 33 SDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPK 92
++DD+E E+ +R+ K A++ E L +A E DS +KKK+E
Sbjct: 189 TNDDEEALDEETKRRDQMIKGAIEVLIREYSSEL--NAPSQESDS---HPRKKKKEKKED 243
Query: 93 LLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQRE----------REMEKGEFDDKEA 142
+ P + L+ +I E E+ I RE E EKG+ + +
Sbjct: 244 IFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQ 303
Query: 143 FVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSF 202
+ +++ +ER E ER +R E + K+K+ + E + +
Sbjct: 304 EIEKERRERERERERERERREREREREREREREKEKE---------RERERERDRDRDRT 354
Query: 203 REARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEE 262
+E E+ R E SS + + E++ D + + + + + E E
Sbjct: 355 KERDRDRDRERDRDRDRERSSDRNKDRSR-------SREKSRDRERERERERERERERER 407
Query: 263 TRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
R RE+ E E + + + + R EE + R + R EK ++
Sbjct: 408 ERER-ERERERER-EREREREKDKKRDREEDEEDAYERRKLERKLR-----EKEAAYQER 460
Query: 323 KQSRDQENHYTDRDYRKE--RDSHRHREASHRDSHWKRH-EQEDKPRARDQRERSDRVWK 379
++ + R+Y KE R+ R RE + K E D R + R + K
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
Query: 380 REKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREK 439
R +DREK E + + D+ R KEE ++R+ D E
Sbjct: 521 RLRDREK------EMEADERDRKR------------EKEELEEIRQRLLAEGHPDPDAEL 562
Query: 440 REVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKP 489
+ + ++ R Q + + P S +++ QE+ K +++E ++KP
Sbjct: 563 QRMEQEAERRRQPQIKQEPESEEEEE-EKQEKEEKREEPMEEEEEPEQKP 611
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 92.8 bits (229), Expect = 7e-19
Identities = 53/212 (25%), Positives = 110/212 (51%), Gaps = 4/212 (1%)
Query: 318 DQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRV 377
D Q+++ R +E +RD ++RD R R+ + + R +Q + R R++ ++ R
Sbjct: 75 DDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRE 134
Query: 378 WKREKDREKYSQREQERDRQ-QNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRD 436
+R++ RE+ R++E++R+ Q +++R ++ + E+ + +E + +E + D+ RD
Sbjct: 135 RERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRD 194
Query: 437 REKREVGVQSSERNQDRKESSPNSRAKDKFLDQE---RSNKMRNMAKDKERNQEKPSNSE 493
EK ER++ RK + R D+ ++E R + R+ + KER++E+ E
Sbjct: 195 TEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEE 254
Query: 494 SSLGAKHRLTEEGQEKGKEQERPPEAVSKFAK 525
K +E +EK KE++R + K+ +
Sbjct: 255 RKKERKKERKKERKEKKKEEKRREDKKRKWGE 286
Score = 82.4 bits (202), Expect = 1e-15
Identities = 51/203 (25%), Positives = 99/203 (48%), Gaps = 9/203 (4%)
Query: 239 KVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGH 298
+V E + + D D K + +E N R++ +T E + R + R +RG
Sbjct: 83 RVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQT-EIERDREREKQKGRERERDRGR 141
Query: 299 STRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKR 358
R + R + +D+ Q+++ + +R+ +KER++ R R+ RD+ +R
Sbjct: 142 E-RERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQ-RDTEKER 199
Query: 359 HEQEDKPRAR------DQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEE 412
Q D+ R R +++ +DR +RE DR + QR+++R ++++ + E+ +KE
Sbjct: 200 ERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKER 259
Query: 413 KSKAKEEHMKVRKERYENNDKYR 435
K + K+E + +KE DK R
Sbjct: 260 KKERKKERKEKKKEEKRREDKKR 282
Score = 81.3 bits (199), Expect = 2e-15
Identities = 60/246 (24%), Positives = 119/246 (48%), Gaps = 32/246 (13%)
Query: 241 EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST 300
+ + DAD D D + E RV REK + + D R ++ R E+ +
Sbjct: 67 QAHKDADGD-------DRQRERDRV---REKTEKERDRD----RKRDRERRRKEKETNRN 112
Query: 301 RHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHRE-ASHRDSHWKRH 359
R K + R E RE Q +++ RD+ R+ ++RD + RE + +D +R
Sbjct: 113 RDREKQTEIERDRE-REKQKGRERERDR-----GRERERDRDREKERERQTEKDRDGQRE 166
Query: 360 EQEDKPRARDQRERSDRVWKREKDREKYSQREQERDR-QQNDQNRPSEKGEKEEKSKAKE 418
+ ++ R R++ ++ +R +R++DR++ +++E+ER ++ D+ R ++ + E + E
Sbjct: 167 TETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGE 226
Query: 419 EHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNM 478
R+ER + D+ ++R +R +DRKE R K++ +++ K
Sbjct: 227 RETDRRRERQRDRDRGKER----------DRERDRKEERKKERKKERKKERKEKKKEEKR 276
Query: 479 AKDKER 484
+DK+R
Sbjct: 277 REDKKR 282
Score = 79.0 bits (193), Expect = 1e-14
Identities = 58/216 (26%), Positives = 96/216 (44%), Gaps = 22/216 (10%)
Query: 282 HHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYT---DRDYR 338
H + R +R + R E+R + + ++RD+E DR+
Sbjct: 69 HKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDRERE 128
Query: 339 K------ERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQ 392
K ERD R RE RD +R Q +K R + ++R +R+++REK +RE
Sbjct: 129 KQKGRERERDRGRERERD-RDREKERERQTEKDRDGQRETETER--ERDREREKQKERET 185
Query: 393 ERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 452
ERDR D+ R +EK + + + ++ K + ER D+ +RE + ER +D
Sbjct: 186 ERDR---DRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETD----RRRERQRD 238
Query: 453 RKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEK 488
R R +D+ +E K R + KER ++K
Sbjct: 239 RDRGKERDRERDR---KEERKKERKKERKKERKEKK 271
Score = 69.3 bits (168), Expect = 9e-12
Identities = 49/210 (23%), Positives = 104/210 (49%), Gaps = 25/210 (11%)
Query: 346 HREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR---EKYSQREQERDRQ---QN 399
H++A D R + D+ R + ++ER DR KR+++R EK + R ++R++Q +
Sbjct: 69 HKDADGDD----RQRERDRVREKTEKER-DRDRKRDRERRRKEKETNRNRDREKQTEIER 123
Query: 400 DQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDRE-KREVGVQSSERNQDRKESSP 458
D+ R +KG + E+ + +E +E+ +DR+ +RE +ER +DR+
Sbjct: 124 DREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRET---ETERERDREREKQ 180
Query: 459 NSRAKDKFLDQER-SNKMRNMAKDKERNQEKPSNSESSLGA---------KHRLTEEGQE 508
R ++ D++R + K R D+ER++++ + +E + R + ++
Sbjct: 181 KERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRD 240
Query: 509 KGKEQERPPEAVSKFAKRNNEETVMSARDR 538
+GKE++R + + K +E +++
Sbjct: 241 RGKERDRERDRKEERKKERKKERKKERKEK 270
Score = 62.0 bits (149), Expect = 1e-09
Identities = 47/193 (24%), Positives = 95/193 (49%), Gaps = 10/193 (5%)
Query: 366 RARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRK 425
+A + DR +R++ REK +++E++RDR+++ + R EK + +++ +E+ ++ +
Sbjct: 67 QAHKDADGDDRQRERDRVREK-TEKERDRDRKRDRERRRKEK--ETNRNRDREKQTEIER 123
Query: 426 ERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERN 485
+R K R+RE+ + ER +DR R +K D +R + +D+ER
Sbjct: 124 DREREKQKGRERERD----RGRERERDRDREKERERQTEKDRDGQRETETER-ERDRERE 178
Query: 486 QEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAK-RNNEETVMSARDRYLARQM 544
++K +E + R TE+ +E+ ++ER + ++ + R + DR RQ
Sbjct: 179 KQKERETERDRD-RQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQR 237
Query: 545 ARVNAKTYIEKED 557
R K + D
Sbjct: 238 DRDRGKERDRERD 250
Score = 61.6 bits (148), Expect = 2e-09
Identities = 48/216 (22%), Positives = 113/216 (52%), Gaps = 25/216 (11%)
Query: 350 SHRDSHWKRHEQEDKPRARDQ-RERSDRVWKREKDREKYSQREQERDR----QQNDQNRP 404
+H+D+ + +D+ R RD+ RE++++ E+DR+ R+++R+R ++ ++NR
Sbjct: 68 AHKDA-----DGDDRQRERDRVREKTEK----ERDRD----RKRDRERRRKEKETNRNRD 114
Query: 405 SEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKD 464
EK + E+ + +E+ +ER ++ RDR++ + + +E+++D + + R +D
Sbjct: 115 REKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERD 174
Query: 465 KFLDQER---SNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVS 521
+ ++++ + + R+ +D E+ +E+ ++ E K + TE +E +E ER +
Sbjct: 175 REREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQ-TERQRETDREGERETD--- 230
Query: 522 KFAKRNNEETVMSARDRYLARQMARVNAKTYIEKED 557
+ +R + RDR R+ R + K++
Sbjct: 231 RRRERQRDRDRGKERDRERDRKEERKKERKKERKKE 266
Score = 59.3 bits (142), Expect = 9e-09
Identities = 39/201 (19%), Positives = 94/201 (46%), Gaps = 14/201 (6%)
Query: 210 KEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRR 269
K ++ R + +++NR +++ ++ D + E+ + + D + + + + R+
Sbjct: 97 KRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQ 156
Query: 270 EKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQE 329
+ + + + R ++ R +ER + R + T + E++ D+ + +Q + Q
Sbjct: 157 TEKDRDGQRETETERERDREREKQKER-ETERDRDRQRDTEKERERQTDRERDRQRKTQT 215
Query: 330 NHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ 389
+ D ER++ R RE Q D+ R +++ DR +R+K+R+K +
Sbjct: 216 ERQRETDREGERETDRRRE-----------RQRDRDRGKERDRERDRKEERKKERKK--E 262
Query: 390 REQERDRQQNDQNRPSEKGEK 410
R++ER ++ ++ R +K K
Sbjct: 263 RKKERKEKKKEEKRREDKKRK 283
Score = 42.7 bits (99), Expect = 9e-04
Identities = 49/258 (18%), Positives = 103/258 (39%), Gaps = 45/258 (17%)
Query: 76 DSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKG 135
D+ D+ Q++++ K +DR K + + + +++ + +I+R+RE EK
Sbjct: 71 DADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQ 130
Query: 136 EFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEE 195
+ ++E +++ ++R E+ERE++ +KD G Q E
Sbjct: 131 KGRERE---RDRGRERERDRDREKERERQT-----------EKDRDG-------QRETET 169
Query: 196 EVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSS 255
E + RE + + E+ R + T+ + E D + D K+
Sbjct: 170 ERERDREREKQKERETERDRDRQRD---------------TEKERERQTDRERDRQRKTQ 214
Query: 256 ADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSR-TSRGHE 314
+ + E R R E D + R ++ R +R + K R R E
Sbjct: 215 TERQRETDREGER--------ETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKE 266
Query: 315 KREDQHQQKQSRDQENHY 332
++E + ++K+ D++ +
Sbjct: 267 RKEKKKEEKRREDKKRKW 284
Score = 31.2 bits (69), Expect = 2.6
Identities = 23/133 (17%), Positives = 63/133 (47%), Gaps = 7/133 (5%)
Query: 32 DSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNP 91
D D + E R+ ++ ++ + ++ E T + D D ++++ + +
Sbjct: 146 DRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDR 205
Query: 92 KLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKK 151
+ +DR+ K + + +E E+ +++ +R+R+ ++G+ D+E KK+
Sbjct: 206 E----RDRQRKTQTERQRETD---REGERETDRRRERQRDRDRGKERDRERDRKEERKKE 258
Query: 152 LQERAEEEEREKR 164
++ ++E +EK+
Sbjct: 259 RKKERKKERKEKK 271
Score = 30.0 bits (66), Expect = 5.8
Identities = 26/131 (19%), Positives = 56/131 (42%), Gaps = 7/131 (5%)
Query: 32 DSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNP 91
D D ET RE K++ + + ++ E + D D +K + E
Sbjct: 160 DRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQR 219
Query: 92 KLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKK 151
+ +R+ R++++++ E+ +R+R+ E+ + KE KKK
Sbjct: 220 ETDREGERETDRRRE-------RQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKK 272
Query: 152 LQERAEEEERE 162
++R E+++R+
Sbjct: 273 EEKRREDKKRK 283
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 92.0 bits (227), Expect = 1e-18
Identities = 52/182 (28%), Positives = 99/182 (54%), Gaps = 10/182 (5%)
Query: 317 EDQHQQKQSRDQ-ENHYTDRDYRKERDSHRHREASHR--DSHWKRHEQEDKPRARDQRER 373
E Q ++K+ D+ + +RD ++ER++ RE HR D H +R Q D+ + R++++
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 374 SDRVWKREKDREKYSQREQERDRQ-----QNDQNRPSEKG--EKEEKSKAKEEHMKVRKE 426
DR +RE++ E+ ++R++ER RQ Q D+ R ++ K E + +E + K +E
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 427 RYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQ 486
R + ++ RDRE+ + ER + R+ R + ++ ++E K R + KER +
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKE 181
Query: 487 EK 488
+K
Sbjct: 182 KK 183
Score = 89.4 bits (220), Expect = 8e-18
Identities = 48/194 (24%), Positives = 101/194 (52%), Gaps = 5/194 (2%)
Query: 286 QNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHR 345
+ R +RG T R +RE++H+Q+ + + TDR+ +ER R
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62
Query: 346 HREASH-RDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQ-NR 403
R+ R++ + Q ++ R R+++ ++DR +R+KDR++ +RE +R+R++N + R
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDR--ERDKDRDRERKRETDRNRERNRKGGR 120
Query: 404 PSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREK-REVGVQSSERNQDRKESSPNSRA 462
+K + E+ + +E + +ER ++ R+ ++ R+ + ER ++RK+ R
Sbjct: 121 ERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERK 180
Query: 463 KDKFLDQERSNKMR 476
+ K ++ R +K R
Sbjct: 181 EKKKEEKRREDKKR 194
Score = 82.0 bits (201), Expect = 1e-15
Identities = 56/211 (26%), Positives = 103/211 (48%), Gaps = 23/211 (10%)
Query: 321 QQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKR 380
++++ R +E TDR ER+ R RE ++ RH Q D+ R RD R
Sbjct: 2 ERQRERKRE---TDRGKETERERDRQRERENQTERENRHRQRDRHRERD----------R 48
Query: 381 EKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKR 440
+ DREK +R++ERDRQ+ + E E +++ + E + R ER D+ RD+++
Sbjct: 49 QTDREKERERQKERDRQRQRER------ETERETERQRERQRQR-ERKRQTDRERDKDRD 101
Query: 441 EVGVQSSERNQDRKESSPNSRAKDKFLDQERS-NKMRNMAKDKERNQEKPSNSESSLGAK 499
+ ++RN++R R +DK ++ER + R +++ER +++ E+ +
Sbjct: 102 RERKRETDRNRERNRK--GGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQ 159
Query: 500 HRLTEEGQEKGKEQERPPEAVSKFAKRNNEE 530
E ++K +++ER E K + E
Sbjct: 160 RWAEREERKKERKKERKKERKEKKKEEKRRE 190
Score = 75.9 bits (185), Expect = 9e-14
Identities = 51/196 (26%), Positives = 95/196 (48%), Gaps = 22/196 (11%)
Query: 268 RREKVIETP---ENDFKHHRSQNHSRSPSEERGHSTR--HHTKGSRTSRGHEKREDQHQQ 322
+RE+ ET E + + R + E H R H + +T R EK ++ ++
Sbjct: 4 QRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDR--EKERERQKE 61
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASH---------RDSHWKRHEQEDKPRARDQRER 373
+ + Q T+R+ ++R+ R RE RD KR ++ R R
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 374 SDRVWKREKDREKYSQREQERDRQ-QNDQNRPSEK-----GEKEEKSKAKEEHMKVRKER 427
D+ +RE+DRE+ QR++ER+RQ Q ++ R +++ E+EE+ K +++ K ++
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKE 181
Query: 428 YENNDKYRDREKREVG 443
+ +K R+ +KR+ G
Sbjct: 182 KKKEEKRREDKKRKWG 197
Score = 72.0 bits (175), Expect = 1e-12
Identities = 49/200 (24%), Positives = 94/200 (47%), Gaps = 13/200 (6%)
Query: 235 QTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSE 294
+TD E + D + ++ + E + + RE+ +T D + R + R
Sbjct: 10 ETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQT---DREKERERQKERDRQR 66
Query: 295 ERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDS 354
+R T T+ R +R+ Q ++K+ D+E DRD ++R++ R+RE + +
Sbjct: 67 QRERETERETERQR------ERQRQRERKRQTDRERD-KDRDRERKRETDRNRERNRKGG 119
Query: 355 HWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKS 414
R + R RD+ R +RE+ R++ +RE +R+RQ+ + +K K+E+
Sbjct: 120 ---RERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176
Query: 415 KAKEEHMKVRKERYENNDKY 434
K ++E K K R + K+
Sbjct: 177 KERKEKKKEEKRREDKKRKW 196
Score = 67.4 bits (163), Expect = 3e-11
Identities = 46/189 (24%), Positives = 89/189 (47%), Gaps = 16/189 (8%)
Query: 370 QRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYE 429
QRER KRE DR K ++RE++R R++ +Q + + ++ + ++ KER
Sbjct: 4 QRER-----KRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERER 58
Query: 430 NNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKP 489
++ R R++ + +ER ++R+ R D+ D++R D+ER +E
Sbjct: 59 QKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDR---------DRERKRETD 109
Query: 490 SNSE-SSLGAKHRLTEEGQEKGKEQERPPEAV-SKFAKRNNEETVMSARDRYLARQMARV 547
N E + G + R + +E+ +E+ER + + +R + R R+ R+ +
Sbjct: 110 RNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169
Query: 548 NAKTYIEKE 556
K +KE
Sbjct: 170 ERKKERKKE 178
Score = 63.2 bits (152), Expect = 6e-10
Identities = 42/193 (21%), Positives = 95/193 (49%), Gaps = 10/193 (5%)
Query: 366 RARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRK 425
R R+++ +DR + E++R++ QRE+E ++ +++R ++ + ++ +E+ + +K
Sbjct: 3 RQRERKRETDRGKETERERDR--QRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60
Query: 426 ERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKM-RNMAKDKER 484
ER + + R+RE + ER + R+ R +DK D+ER + RN ++++
Sbjct: 61 ER--DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKG 118
Query: 485 NQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQM 544
+E+ +E + R E +++ +E+ER + K + +R R+
Sbjct: 119 GRERDKQTE-----RERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKK 173
Query: 545 ARVNAKTYIEKED 557
R + +KE+
Sbjct: 174 ERKKERKEKKKEE 186
Score = 53.5 bits (127), Expect = 5e-07
Identities = 45/206 (21%), Positives = 88/206 (42%), Gaps = 15/206 (7%)
Query: 203 REARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEE 262
RE G + E+ R E +N+ +E Q D E + D + + + + + +
Sbjct: 9 RETDRGKETERERDRQRE--RENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQR 66
Query: 263 TRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
R + E + R + R ++R + T +R RE Q
Sbjct: 67 QRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQT 126
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREK 382
++ RD+E +R ++ER+ R RE R + D+ R R ER +R +R+K
Sbjct: 127 ERERDRER---ERQRQRERERQRQRE---------RKRETDRERQR-WAEREERKKERKK 173
Query: 383 DREKYSQREQERDRQQNDQNRPSEKG 408
+R+K + +++ ++++ D+ R +G
Sbjct: 174 ERKKERKEKKKEEKRREDKKRKWGEG 199
Score = 47.8 bits (112), Expect = 3e-05
Identities = 57/257 (22%), Positives = 100/257 (38%), Gaps = 61/257 (23%)
Query: 122 MEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLS 181
ME++ +R+RE ++G+ ++E + + +ER + ERE R +Q+D
Sbjct: 1 MERQRERKRETDRGKETERE-------RDRQRERENQTERENR----------HRQRD-- 41
Query: 182 GFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVE 241
RH RE EK R K R Q + +T+ + E
Sbjct: 42 ---RH----------------RERDRQTDREKER-----ERQKERDRQRQRERETERETE 77
Query: 242 ENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTR 301
+ + K D E ++ R RE+ ET R++ +R ER T
Sbjct: 78 RQRERQRQRERKRQTDRERDKDR---DRERKRET-------DRNRERNRKGGRERDKQTE 127
Query: 302 HHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQ 361
R + +RE Q Q+++ R+ + R+ER R +E ++ E+
Sbjct: 128 RERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKE--------RKKER 179
Query: 362 EDKPRARDQRERSDRVW 378
++K + +RE R W
Sbjct: 180 KEKKKEEKRREDKKRKW 196
Score = 33.9 bits (76), Expect = 0.40
Identities = 14/51 (27%), Positives = 34/51 (66%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKR 164
R++E+E++ +++ +RE + E+ + ++E K++ +ER E+++ EKR
Sbjct: 138 RQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKR 188
Score = 32.7 bits (73), Expect = 0.90
Identities = 25/120 (20%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 46 QREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIH 105
QRE ++ ++ + ++ + T E D D +K++ + N ++R K
Sbjct: 67 QRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRN------RERNRKGGR 120
Query: 106 NLLKAVEI-RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKR 164
K E R +E+E++ +++ +R+R+ E+ D+E + +++ +ER +E ++E++
Sbjct: 121 ERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERK 180
Score = 29.3 bits (64), Expect = 10.0
Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQ---ERAEEEEREKR 164
R+KE+E++ E+ QR+RE E +++ ++K Q ER ++ +RE++
Sbjct: 52 REKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERK 105
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 91.7 bits (226), Expect = 2e-18
Identities = 101/429 (23%), Positives = 204/429 (47%), Gaps = 32/429 (7%)
Query: 104 IHNLLKAVEIRKKEQEKRMEKKIQRER-----EMEKGEFDDKEAFVTSAYKKKLQERAEE 158
+ L AV +KK+ ++ +E+ + +ER E+ + D+E +A KLQE+ +
Sbjct: 177 LEQALSAVATQKKKADRYIEE-LTKERDALSLELYRNTITDEELKEKNA---KLQEKLQL 232
Query: 159 EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFS 218
E EK E L+V + K + LL Q + E +E +S + +++
Sbjct: 233 VESEKS----EIQLNVKELKRKLERAKLLLPQQQLQAEADHLG-KELQSVSAKLQAQVEE 287
Query: 219 NEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDE-IEETRVNCRREKVIETPE 277
NE+ ++ QE+ + + + K++E + + + K +E I E RR++ + +
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK 347
Query: 278 NDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDY 337
+ R Q EE+ + + E E H+Q++ R+QE + +
Sbjct: 348 EE--KMRRQEEMMWEKEEKMRRLEE-MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 404
Query: 338 RKERDSHRHREASHRDSHWKRHEQEDKPRARDQR--ERSDRVWKREKDREKYSQREQ--- 392
+E++ + +EA K EQE+K R ++++ + +++ ++EK RE+ ++EQ
Sbjct: 405 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Query: 393 ----ERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKER-YENNDKYRDREKREVGVQSS 447
E+ R+Q + R EK ++EK + +EE + ++E+ ++ +K R++E++ +
Sbjct: 465 WRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEK 524
Query: 448 ERNQDRK--ESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEE 505
R Q+ K E R +++ + QE+ KM ++K + QEK E + + E
Sbjct: 525 IREQEEKIREQEEKIREQEEMM-QEQEEKMGEQ-EEKMQEQEKMRRQEEKIREQEEKIRE 582
Query: 506 GQEKGKEQE 514
+EK +EQE
Sbjct: 583 QKEKIREQE 591
Score = 86.7 bits (213), Expect = 5e-17
Identities = 108/500 (21%), Positives = 222/500 (44%), Gaps = 66/500 (13%)
Query: 37 DETSVSESLQREAAKKQAMKQTKLEIQKALA-EDATVYEYDSIYDEMQKKKEENNPKLLL 95
+ ++S L R + +K+ ++Q+ L ++ E E+++K E KLLL
Sbjct: 201 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER--AKLLL 258
Query: 96 GKDRKPKYIHNLLKAVE-----IRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKK 150
+ + +L K ++ ++ + +E + ++ +++E + ++K +++
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK----IQEWEE 314
Query: 151 KLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIK 210
K+QE+ EE+ RE+ E + +Q+++ E+ K +E K
Sbjct: 315 KIQEQ-EEKIREQEEKIREQEEKMRRQEEMMW------------EKEEKMRRQEEMMWEK 361
Query: 211 EEKSRGFSN---EVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNC 267
EEK R E K R +EK Q ++ +E + + + E +E ++
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE-QEAKMWR 420
Query: 268 RREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQH----QQK 323
+ EK+ E E R Q EE+ H R EKR++Q Q++
Sbjct: 421 QEEKIREQEEKI----REQEKKMWRQEEKIHE-------QEKIREEEKRQEQEEMWRQEE 469
Query: 324 QSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKRE-- 381
+ R+QE + ++ E++ R +E K H+QE+K R E+ +++W++E
Sbjct: 470 KIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIR-----EQEEKMWRQEEK 524
Query: 382 -KDREKYSQREQERDRQQND--QNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRD-- 436
+++E+ + ++E+ R+Q + Q + + GE+EEK + +E+ + ++ E +K R+
Sbjct: 525 IREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQK 584
Query: 437 ---REKREVGVQSSERNQDRKESSPNSRAK-----DKFLDQERSNKMRNMAKDKERNQEK 488
RE+ E + E+ ++++E K +K +QE KM+ + R +EK
Sbjct: 585 EKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQE--EKMQEQEEKMRRQEEK 642
Query: 489 PSNSESSLGAKHRLTEEGQE 508
E L + +E QE
Sbjct: 643 MWEQEVRLRQQEEKMQEHQE 662
Score = 79.0 bits (193), Expect = 1e-14
Identities = 83/401 (20%), Positives = 178/401 (44%), Gaps = 22/401 (5%)
Query: 40 SVSESLQREAAKKQAMKQ-TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKD 98
SVS LQ + + + + + + +K ++ + E++ E ++K E K+ ++
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR-EQE 334
Query: 99 RKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEE 158
K + ++ E + + QE+ M +K ++ R +E+ ++ +E K QE+ E
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIRE 394
Query: 159 EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEV---PKCSFREARSGIKEEKSR 215
+E EKR + +Q+ + +R EE++ K +R+ ++EK R
Sbjct: 395 QE-EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 453
Query: 216 GFSNEVSSKNRIPQEKCIL-QTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIE 274
+ QE+ I Q ++ ++ + + K +E +++ + EK+ E
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 275 TPENDFKHH---RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENH 331
E ++ R Q EE+ + G ++ + Q Q+K R +E
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK- 572
Query: 332 YTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQ--RERSDRVWKREKDREKYSQ 389
R++ + R ++ R+ K EQE+K R +++ +E+ +++W++E EK +
Sbjct: 573 -----IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQE---EKMCE 624
Query: 390 REQERDRQQNDQNRPSEK-GEKEEKSKAKEEHMKVRKERYE 429
+E++ Q+ R EK E+E + + +EE M+ +E E
Sbjct: 625 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 77.4 bits (189), Expect = 3e-14
Identities = 101/505 (20%), Positives = 219/505 (43%), Gaps = 50/505 (9%)
Query: 51 KKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKA 110
KK+A + + ++ A +Y +E+++K + KL L + K +
Sbjct: 188 KKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSE-------- 239
Query: 111 VEIRKKEQEKRMEK-KIQREREMEKGEFDD--KEAFVTSAYKKKLQERAEEEEREKRAAA 167
+++ KE ++++E+ K+ ++ + E D KE SA KLQ + EE E R
Sbjct: 240 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA---KLQAQVEENELWNRL-- 294
Query: 168 LEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRI 227
Q+ +R EE++ + +E + +EEK R E K R
Sbjct: 295 --------NQQQEEKMWRQEEKIQEWEEKIQE---QEEKIREQEEKIR----EQEEKMR- 338
Query: 228 PQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQN 287
QE+ + + + K+ + + + K +E+ + RE +E ++ + R Q
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE--LEEKMHEQEKIREQE 396
Query: 288 HSRSPSEERGHSTRHHTKGSRTSRGHEKREDQH-----QQKQSRDQENHYTDRDYRKERD 342
R E+ + + ++ R EK +Q Q+K+ QE +++ +E +
Sbjct: 397 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 456
Query: 343 SHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQN 402
+ +E R K EQE+ R +++ +++ R+++ + + Q E+ D+++ +
Sbjct: 457 KRQEQEEMWRQEE-KIREQEEIWRQKEKMHEQEKI--RKQEEKVWRQEEKMHDQEEKIRE 513
Query: 403 RPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRA 462
+ + +EEK + +EE ++ ++E+ ++ ++ ++G E+ + +E R
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG----EQEEKMQEQEKMRRQ 569
Query: 463 KDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSK 522
++K +QE K+R + +EK E + + + +E +EK EQE + +
Sbjct: 570 EEKIREQE--EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE--KMCEQ 625
Query: 523 FAKRNNEETVMSARDRYLARQMARV 547
K +E M ++ + Q R+
Sbjct: 626 EEKMQEQEEKMRRQEEKMWEQEVRL 650
Score = 75.5 bits (184), Expect = 1e-13
Identities = 92/468 (19%), Positives = 197/468 (42%), Gaps = 56/468 (11%)
Query: 103 YIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEERE 162
Y + +K +E ++ R+ + E+E+ + KKK EE +E
Sbjct: 148 YSQHAVKQLEGEARDLISRLHDSWKFAGELEQA------LSAVATQKKKADRYIEELTKE 201
Query: 163 KRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVS 222
+ A +LE YR+ + +E+ K +E ++ EKS N
Sbjct: 202 RDALSLE-------------LYRNTITDEELKEKNAK--LQEKLQLVESEKSEIQLNVKE 246
Query: 223 SKNRIPQEKCIL---QTDVKVEENPDADSDFDAKSSADDEIEE--TRVNCRREKVIETPE 277
K ++ + K +L Q + + AK A E E R+N ++E+ + E
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 306
Query: 278 NDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQ---HQQKQSRDQENHYTD 334
+ + +E+ R + R +R+++ ++++ R QE +
Sbjct: 307 EKIQEWEEK------IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 335 RDYRKER--DSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ--R 390
++ + R + +E R+ K HEQE ++R+ +++ ++EK +E+ ++ R
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 420
Query: 391 EQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERN 450
++E+ R+Q EEK + +E+ M ++E+ +K R+ EKR+ + +
Sbjct: 421 QEEKIREQ------------EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 468
Query: 451 QDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKG 510
+ +E R K+K +QE K+R + R +EK + E + + +EK
Sbjct: 469 EKIREQEEIWRQKEKMHEQE---KIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKI 525
Query: 511 KEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 558
+EQE + + K +E +M ++ + Q ++ + + ++++
Sbjct: 526 REQEE--KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571
Score = 35.0 bits (79), Expect = 0.18
Identities = 25/136 (18%), Positives = 66/136 (48%), Gaps = 2/136 (1%)
Query: 34 DDDDETSVSESLQREAAKKQAMKQTKLEIQKALA-EDATVYEYDSIYDEMQKKKEENNPK 92
+ +++ E + +E +K ++ K++ Q+ + ++ + E + E ++K E K
Sbjct: 534 EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Query: 93 LLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKL 152
+ ++ K + +++ E + EQE++M ++ ++ +E E+ +E + +
Sbjct: 594 IW-EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
Query: 153 QERAEEEEREKRAAAL 168
QE +E +E AA+
Sbjct: 653 QEEKMQEHQEHLEAAI 668
Score = 32.7 bits (73), Expect = 0.90
Identities = 36/212 (16%), Positives = 98/212 (46%), Gaps = 19/212 (8%)
Query: 36 DDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLL 95
+++ E + R+ K ++ + + +K ++ +++ + E ++K K+
Sbjct: 468 EEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIRE 527
Query: 96 GKDRKPKYIHNLLKAVEIRKKEQEK--RMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQ 153
+++ + + + E+ ++++EK E+K+Q + +M + E +E ++K++
Sbjct: 528 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIRE------QEEKIR 581
Query: 154 ERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEK 213
E+ +E+ RE+ E + +Q+++ + + E+E C +E + +EEK
Sbjct: 582 EQ-KEKIREQEEKIWEQEEKIREQEEM----MQEQEEKMWEQEEKMCE-QEEKMQEQEEK 635
Query: 214 SRGFSNEVSSKNRIPQEKCILQTDVKVEENPD 245
R + QE + Q + K++E+ +
Sbjct: 636 MRR-----QEEKMWEQEVRLRQQEEKMQEHQE 662
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 90.9 bits (224), Expect = 3e-18
Identities = 108/518 (20%), Positives = 226/518 (43%), Gaps = 76/518 (14%)
Query: 34 DDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKL 93
+DDDE + +R A +++ ++ + E + + V +S+ DE K N
Sbjct: 30 NDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ-- 87
Query: 94 LLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQ 153
+ D + ++ L + R++ ++KR+++ ++R++E + D A ++ ++
Sbjct: 88 -VEGDDEAAFLERLAR----REERRQKRLQEALERQKEFDPTITD---ASLSLPSRRMQN 139
Query: 154 ERAEEE--EREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKE 211
+ AE E E+E+++ + + ++ + + ++ Y+ K +R+A KE
Sbjct: 140 DTAENETTEKEEKSESRQERYEIEETETVTKSYQ-------------KNDWRDAEENKKE 186
Query: 212 EKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREK 271
+K + E K E Q +V VEE + EET V +
Sbjct: 187 DKEKEEEEEEKPKRGSIGEN---QVEVMVEEK------------TTESQEETVVMSLKNG 231
Query: 272 VIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENH 331
I + E + R Q S+E HH K + E+ E + + ++ ++E
Sbjct: 232 QISSEEPKQEEEREQG-----SDE----ISHHEKMEEEDK--ERAEAERARLEAEERERI 280
Query: 332 YTDRDYRKERDSHRHREASHRDS--HWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ 389
++D +K D EA + + +R E E++ R R++ +R+ +R K+ EK +
Sbjct: 281 KAEQD-KKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAA 339
Query: 390 REQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSER 449
E++R +++ EK EE+ + KEE + +ER + R E+ + V+ +R
Sbjct: 340 EERQRIKEE-------EKRAAEERQRIKEEEKRAAEER----QRARAEEEEKAKVEEQKR 388
Query: 450 N---QDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERN------QEKPSNSESSLGAKH 500
N +++K + ++ K + ++Q+ K N K +E +++ + + AK
Sbjct: 389 NKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKR 448
Query: 501 RLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDR 538
+E + K++E E + K + +E V S DR
Sbjct: 449 EKLQEDKPTFKKEEIKDEKIKK--DKEPKEEVKSFMDR 484
Score = 83.6 bits (205), Expect = 4e-16
Identities = 85/453 (18%), Positives = 187/453 (41%), Gaps = 38/453 (8%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
R+ ++KR E +++ ER + DD+E ++ QER +++ E+ + ++
Sbjct: 8 RELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE 67
Query: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCI 233
V Q + E + +F E + +E + + + + + I
Sbjct: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF--DPTI 125
Query: 234 LQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPS 293
+ + + + +++ +E E+R + ET ++ + ++ +
Sbjct: 126 TDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK 185
Query: 294 EERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYT------DRDYRKERDSHRHR 347
E++ K R S G + E ++K + QE + +
Sbjct: 186 EDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEERE 245
Query: 348 EASHRDSHWKRHEQEDKPRARDQR-----ERSDRVWKREKDR------------EKYSQR 390
+ S SH ++ E+EDK RA +R E +R+ K E+D+ EK + +
Sbjct: 246 QGSDEISHHEKMEEEDKERAEAERARLEAEERERI-KAEQDKKIADERARIEAEEKAAAQ 304
Query: 391 EQE-RDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSER 449
E+E R+ ++ ++ R EK EE+ + KEE + +ER + ++ EKR + +
Sbjct: 305 ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER----QRIKEEEKRAAEERQRIK 360
Query: 450 NQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSL-GAKHRLTEEGQ- 507
++++ + RA+ ++E K+ ++K+ ++K + E+ + G K EG+
Sbjct: 361 EEEKRAAEERQRAR---AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW 417
Query: 508 --EKGKEQERPPEAVSKFAKRNNEETVMSARDR 538
EK ++++ AV K V + R++
Sbjct: 418 VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450
Score = 60.1 bits (144), Expect = 5e-09
Identities = 89/436 (20%), Positives = 183/436 (41%), Gaps = 43/436 (9%)
Query: 1 MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKL 60
M++ Q PK+ ++ + S ++D E + +E + EA +++ +K
Sbjct: 226 MSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA--- 282
Query: 61 EIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRK--KEQ 118
E K +A++ E + ++++ E + + ++ K +A E R+ KE+
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMREEEK--------RAAEERQRIKEE 334
Query: 119 EKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALE-ACLDVTKQ 177
EKR ++ QR +E EK ++++ K+ ++RA EE + RA E A ++ K+
Sbjct: 335 EKRAAEERQRIKEEEKRAAEERQRI------KEEEKRAAEERQRARAEEEEKAKVEEQKR 388
Query: 178 KDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTD 237
+H + + + E K + + E+K++ + + + +EK +
Sbjct: 389 NKQLEEKKHAMQETKIKGE--KVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGT-KVQ 445
Query: 238 VKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERG 297
K E+ + F + D++I++ + K + F +SQN E
Sbjct: 446 AKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN-----GEFMT 500
Query: 298 HSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWK 357
H +H T+ + + G D + + + E K + R R ++
Sbjct: 501 HKLKH-TENTFSRPGGRASVDTKEAEGAPQVEAG-------KRLEELRRRRGETESEEFE 552
Query: 358 RHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAK 417
+ +Q+ + A + E KRE+ R+ + EQ R +++ D+ + E+EEK + K
Sbjct: 553 KLKQKQQEAALELEELKK---KREERRKVLEEEEQRRKQEEADR----KLREEEEKRRLK 605
Query: 418 EEHMKVRKERYENNDK 433
EE + R E E K
Sbjct: 606 EEIERRRAEAAEKRQK 621
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/325 (20%), Positives = 133/325 (40%), Gaps = 20/325 (6%)
Query: 248 SDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGS 307
+D D + +A + R R+K E N S +E +T +T+
Sbjct: 30 NDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVE 89
Query: 308 ---------RTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKR 358
R +R E+R+ + Q+ R +E T D S R + + + ++
Sbjct: 90 GDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEK 149
Query: 359 HEQEDKPRARDQRERSDRVWKRE-----KDREKYSQREQERDRQQNDQNRPSEKGEKEEK 413
E+ + + R + E ++ V K +D E+ + ++E++ ++ ++ + GE + +
Sbjct: 150 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209
Query: 414 SKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSN 473
+E+ + ++E + K + E Q ER Q E S + + +++ D+ER+
Sbjct: 210 VMVEEKTTESQEETVVMSLK-NGQISSEEPKQEEEREQGSDEISHHEKMEEE--DKERAE 266
Query: 474 KMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERP-PEAVSKFAKRNNEETV 532
R + +ER + K + + R+ E +EK QER EA + R E+
Sbjct: 267 AERARLEAEERERIKAEQDKKIADERARI--EAEEKAAAQERERREAEERERMREEEKRA 324
Query: 533 MSARDRYLARQMARVNAKTYIEKED 557
R R + + I++E+
Sbjct: 325 AEERQRIKEEEKRAAEERQRIKEEE 349
Score = 57.0 bits (136), Expect = 4e-08
Identities = 102/572 (17%), Positives = 228/572 (39%), Gaps = 62/572 (10%)
Query: 23 LQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEM 82
L PS + ++ET+ E ++ +++T+ + D E + D+
Sbjct: 130 LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKE 189
Query: 83 QKKKEENNPKL-LLGKDR------------KPKYIHNLLKAVEIRKKE--QEKRMEKKIQ 127
++++EE PK +G+++ + + + LK +I +E QE+ E+
Sbjct: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSD 249
Query: 128 REREMEKGEFDDKEAFVTSAYKKKLQERAE-EEEREKRAAALEACLDVTKQKDLSGFYRH 186
EK E +DKE + + +ER + E++K+ A A ++ ++ R
Sbjct: 250 EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERR 309
Query: 187 LLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSK---NRIPQEKCILQTDVK--VE 241
+ E K + E R IKEE+ R K R +E+ ++ + K E
Sbjct: 310 EAEERERMREEEKRA-AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 368
Query: 242 ENPDADSDFDAKSSADDE------------IEETRVNCRREKVIETPENDFKHHRSQNHS 289
E A ++ + K+ +++ ++ET++ + EKV + E + + +
Sbjct: 369 ERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI--KGEKVEQKIEGKWVNEKKAQED 426
Query: 290 -------RSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERD 342
+ EE+G + + + + K+E+ +K +D+E + + +
Sbjct: 427 KLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 486
Query: 343 SHRHREASHRD--SHWKRHEQE--DKPRARDQRERSDRVWKREKDREKYSQREQERDRQQ 398
++ + + +H +H + +P R + + + + K + + R +
Sbjct: 487 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET 546
Query: 399 NDQNRPSEKGEKEEKSKAKEEHMKVRKER---YENNDKYRDREKREVGVQSSERNQDRKE 455
+ K +++E + EE K R+ER E ++ R +E+ + ++ E + KE
Sbjct: 547 ESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKE 606
Query: 456 SSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515
RA E + K + M +D + +KP + G+ ++ E + K ++
Sbjct: 607 EIERRRA-------EAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 659
Query: 516 PPEAVSKFAKRNNEETVMSARDRYLARQMARV 547
S K ++ ++S D L + + +
Sbjct: 660 -----SSGVKSTHQAAIVSKIDSRLEQYTSAI 686
Score = 40.0 bits (92), Expect = 0.006
Identities = 35/168 (20%), Positives = 83/168 (49%), Gaps = 24/168 (14%)
Query: 379 KREKDREKYSQREQERDR---QQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYR 435
+RE R+K + E +R Q+ND + E+ +E + +A++E ++ ++E E+ +
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDE--EEAARERRRRARQERLRQKQEE-ESLGQVT 63
Query: 436 DREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEK------- 488
D+ EV Q+S +++ K ++ N++ + + + + +A+ +ER Q++
Sbjct: 64 DQV--EVNAQNSVPDEEAKTTTTNTQVEG----DDEAAFLERLARREERRQKRLQEALER 117
Query: 489 -----PSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEET 531
P+ +++SL R + + + E+ ++ S+ + EET
Sbjct: 118 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 87.4 bits (215), Expect = 3e-17
Identities = 54/213 (25%), Positives = 111/213 (52%), Gaps = 21/213 (9%)
Query: 322 QKQSRDQENHY-TDRDYRKERDSHRHREASHRDSHWKRHEQEDK----------PRARDQ 370
Q + R++E T ++ +KER+S R +E R+ + E+E K R +++
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 371 RERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKG-EKEEKSKAKEEHMKVRKERYE 429
RER R +REK+ ++ ++E+ + +++ ++ R S++G E+E K + K E K R+ + E
Sbjct: 95 RERKKR--RREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 430 NNDKYRD------REKREVGVQSSERNQ-DRKESSPNSRAKDKFLDQERSNKMRNMAKDK 482
+K R+ RE+++VG + ER + +RKE R + + + + R K++
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKER 212
Query: 483 ERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515
++ +E+ + R E G+ + KE+++
Sbjct: 213 KKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 86.3 bits (212), Expect = 7e-17
Identities = 54/222 (24%), Positives = 102/222 (45%), Gaps = 21/222 (9%)
Query: 269 REKVIETPENDFKHHRSQN----HSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQ 324
RE+ IET + K S+ R + R +G + +G K+E++ ++K+
Sbjct: 41 REREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR 100
Query: 325 SRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR 384
R++EN + ++++ + R + ++ + ++E K R +RER
Sbjct: 101 RREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERER----------- 149
Query: 385 EKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGV 444
K +RE+ER+R++ + + GEKEE+ K KE RKER + ++R+K
Sbjct: 150 -KKEEREKERERKERKKRERKQVGEKEEERKEKE-----RKERKKRERNRKERKKERERK 203
Query: 445 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQ 486
+ ER ++RK+ + + K K R + KER +
Sbjct: 204 ERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 77.8 bits (190), Expect = 2e-14
Identities = 52/196 (26%), Positives = 102/196 (52%), Gaps = 17/196 (8%)
Query: 345 RHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDR--------EKYSQREQERDR 396
R RE R K E E R +++RER R +REK+R +K ++++ER+R
Sbjct: 41 REREIETRKEGKKERESE---RKKERREREKRKREREKERKRERGKKEKKGERKKEERER 97
Query: 397 QQNDQNRPSEKGEKEEKSKAKEEHMKVR-----KERYENNDKYR-DREKREVGVQSSERN 450
++ + + +++GE++EK K KE+ + R KER ++ R +R++RE + E+
Sbjct: 98 KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKE 157
Query: 451 QDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKG 510
++RKE R + ++ER K R K +ERN+++ + R E +++
Sbjct: 158 RERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEE 217
Query: 511 KEQERPPEAVSKFAKR 526
+++ER + + + ++
Sbjct: 218 RKKERQKDRQTNWREK 233
Score = 74.3 bits (181), Expect = 3e-13
Identities = 42/171 (24%), Positives = 90/171 (52%), Gaps = 5/171 (2%)
Query: 360 EQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEE 419
+ E + R R+ R + +RE +R+K +RE+E+ +++ ++ R E+G+KE+K + K+E
Sbjct: 35 QSEIREREREIETRKEGKKERESERKK-ERREREKRKREREKERKRERGKKEKKGERKKE 93
Query: 420 HMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMA 479
+ +K R E +K + +++ + ER + KE R +++ ++ + + +
Sbjct: 94 ERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEE 153
Query: 480 KDKER-NQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNE 529
++KER +E+ +G K EE +EK +++ + E K K+ E
Sbjct: 154 REKERERKERKKRERKQVGEKE---EERKEKERKERKKRERNRKERKKERE 201
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/184 (27%), Positives = 89/184 (48%), Gaps = 9/184 (4%)
Query: 354 SHWKRHEQEDKPRARDQRERSDRVWKREKDREKYS-QREQERDRQQNDQNRPSEKGEKEE 412
S + E+E + R ++ER K ++REK +RE+ER R++ + + E+ +KEE
Sbjct: 36 SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGER-KKEE 94
Query: 413 KSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSE-RNQDRKESSPNSRAKDKFLDQER 471
+ + K K KE E +K + +EK+E G S E + ++RKE K++ +E
Sbjct: 95 RERKKRRREKENKEG-EEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEE 153
Query: 472 SNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKG-----KEQERPPEAVSKFAKR 526
K R + K+R +++ E K R + +E+ KE+ER K ++
Sbjct: 154 REKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK 213
Query: 527 NNEE 530
EE
Sbjct: 214 KKEE 217
Score = 70.5 bits (171), Expect = 4e-12
Identities = 46/188 (24%), Positives = 89/188 (47%), Gaps = 6/188 (3%)
Query: 259 EIEETRVNCRREKVIETPENDFKHHRSQNHSRSP--SEERGHSTRHHTKGSRTSRGHEKR 316
E E + REK E + K R + + EER R K ++ EKR
Sbjct: 56 ESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKR 115
Query: 317 EDQHQQKQSR-DQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQ--RER 373
+ + ++++ R +E +R ++R+ + RE + +R +E K R R Q +
Sbjct: 116 KKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKE 175
Query: 374 SDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDK 433
+R K K+R+K + +ER +++ + R K E+++K + K+E K R+ + ++
Sbjct: 176 EERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKER 235
Query: 434 YRDREKRE 441
+ RE++E
Sbjct: 236 GK-RERKE 242
Score = 66.2 bits (160), Expect = 7e-11
Identities = 40/181 (22%), Positives = 89/181 (49%), Gaps = 7/181 (3%)
Query: 239 KVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGH 298
K E + + K + +E R +R + E E + K R + + ERG
Sbjct: 70 KREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKK----ERGR 125
Query: 299 STRHHTKGSRTS-RGHEKREDQHQQKQSRDQENHYTDRDYRKERD-SHRHREASHRDSHW 356
+++ + R R E+R+++ ++K+ R++E +R R+ + + E ++
Sbjct: 126 TSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKE 185
Query: 357 KRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKA 416
++ + ++ + +RER +R +R+K+R+K +R++ER + + R E+G++E K +
Sbjct: 186 RKKRERNRKERKKERERKERR-ERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Query: 417 K 417
K
Sbjct: 245 K 245
Score = 64.3 bits (155), Expect = 3e-10
Identities = 40/180 (22%), Positives = 92/180 (51%), Gaps = 9/180 (5%)
Query: 253 KSSADDEIEETRVNCRREKVIETP--ENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTS 310
K + E E R ++EK E E + K R + ++ E+ + + RTS
Sbjct: 68 KRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTS 127
Query: 311 RGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQ 370
+ ++RE + ++K+ +E ++ER+ R R+ + + E+E++ + +++
Sbjct: 128 KEGKERERKEERKREERKERERK----KEEREKERERKERKKRERKQVGEKEEERKEKER 183
Query: 371 RERSDRV---WKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKER 427
+ER R +R+K+RE+ +RE++++R++ ++ + + +++ + KE + RKER
Sbjct: 184 KERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKER 243
Score = 60.8 bits (146), Expect = 3e-09
Identities = 35/157 (22%), Positives = 71/157 (45%)
Query: 402 NRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSR 461
++P + + + + +E ++ RKE + + R +E+RE + ER ++RK
Sbjct: 26 SKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKE 85
Query: 462 AKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVS 521
K + +ER K R K+ + +EK + + R ++EG+E+ +++ER E
Sbjct: 86 KKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145
Query: 522 KFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD 558
+ ++ E R R+ +V K KE +
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKE 182
Score = 57.0 bits (136), Expect = 4e-08
Identities = 44/187 (23%), Positives = 78/187 (41%), Gaps = 17/187 (9%)
Query: 380 REKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREK 439
RE++RE +++E +++R+ K E+ E+ K K E K RK +K +R+K
Sbjct: 39 REREREIETRKEGKKERESE------RKKERREREKRKREREKERKRERGKKEKKGERKK 92
Query: 440 ---------REVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPS 490
RE + E + RK+ R + +ER K ++++ + K
Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 491 NSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAK 550
E K R E ++ G+++E E K +R E R + R+ R K
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERK--ERKKRERNRKERKKERERKERRERKK 210
Query: 551 TYIEKED 557
+KE+
Sbjct: 211 ERKKKEE 217
Score = 50.1 bits (118), Expect = 5e-06
Identities = 60/270 (22%), Positives = 101/270 (37%), Gaps = 71/270 (26%)
Query: 109 KAVEIRK--KEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAA 166
+ +E RK K++ + KK +RERE K E + + +KK + + EE ER+KR
Sbjct: 43 REIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR-- 100
Query: 167 ALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNR 226
R GEE +E R KE+K RG +++ +
Sbjct: 101 ------------------RREKENKEGEE-------KEKRKK-KEKKERGRTSKEGKERE 134
Query: 227 IPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQ 286
+E+ ++ E R REK E E + R +
Sbjct: 135 RKEER-----------------------KREERKERERKKEEREKERERKE---RKKRER 168
Query: 287 NHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRH 346
EER R K +R K+E + ++++ R +E RK+++ +
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKE--------RKKKEERKK 220
Query: 347 REASHRDSHWKRHEQEDKPRARDQRERSDR 376
R ++W+ E R +RER +R
Sbjct: 221 ERQKDRQTNWREKE-------RGKRERKER 243
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/127 (25%), Positives = 59/127 (46%), Gaps = 2/127 (1%)
Query: 38 ETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGK 97
E E ++E KK+ K+ ++ + E ++KKEE K K
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEERE-KERERK 161
Query: 98 DRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAE 157
+RK K + E +KE+E++ KK +R R+ K E + KE +KK +ER +
Sbjct: 162 ERK-KRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKK 220
Query: 158 EEEREKR 164
E +++++
Sbjct: 221 ERQKDRQ 227
Score = 36.2 bits (82), Expect = 0.081
Identities = 39/178 (21%), Positives = 82/178 (46%), Gaps = 5/178 (2%)
Query: 38 ETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGK 97
ET +RE+ +K+ ++ E +K E E + ++KKEE K +
Sbjct: 46 ETRKEGKKERESERKKERRER--EKRKREREKERKRERGKKEKKGERKKEERERKKRR-R 102
Query: 98 DRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAE 157
+++ K K + KKE+ + ++ +RER+ E+ + KE ++K +ER E
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKE 162
Query: 158 EEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSR 215
++RE++ + + K+K+ + N+ ++E + RE + K+++ R
Sbjct: 163 RKKRERKQVGEKE--EERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Score = 34.3 bits (77), Expect = 0.31
Identities = 28/134 (20%), Positives = 67/134 (50%), Gaps = 12/134 (8%)
Query: 30 GNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEEN 89
G S + E E +RE K++ K+ + E ++ E E + ++ +++KE
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERKK-RERKQVGEKEEERKE-- 180
Query: 90 NPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYK 149
K+RK + + +++E+++R E+K +R+++ E+ + K+ + ++
Sbjct: 181 -------KERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDR--QTNWR 231
Query: 150 KKLQERAEEEEREK 163
+K + + E +ER+K
Sbjct: 232 EKERGKRERKERKK 245
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 87.0 bits (214), Expect = 4e-17
Identities = 105/494 (21%), Positives = 223/494 (45%), Gaps = 59/494 (11%)
Query: 37 DETSVSESLQREAAKKQAMKQTKLEIQKALA-EDATVYEYDSIYDEMQKKKEENNPKLLL 95
+ ++S L R + +K+ ++Q+ L ++ E E+++K E KLLL
Sbjct: 262 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER--AKLLL 319
Query: 96 GKDRKPKYIHNLLKAVE-----IRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKK 150
+ + +L K ++ ++ + +E + ++ +++E + ++K +++
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK----IQEWEE 375
Query: 151 KLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLN--QAVGEEEVPKCSFREARSG 208
K+QE+ EE+ RE+ E + +Q+++ + + + E+ K +E
Sbjct: 376 KIQEQ-EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 434
Query: 209 IKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCR 268
KEEK R ++ + +I +++ Q + K+ E +E ++ +
Sbjct: 435 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE------------QEAKMWRQ 482
Query: 269 REKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQH----QQKQ 324
EK+ E E R Q EE+ H R EKR++Q Q+++
Sbjct: 483 EEKIREQEEKI----REQEEKMWRQEEKIHE-------QEKIREEEKRQEQEEMWRQEEK 531
Query: 325 SRDQENHYTDRDYRKERDSH-RHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKRE-- 381
R+QE + ++ E++ R +E K H+QE+K R E+ ++VW++E
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR-----EQEEKVWRQEEK 586
Query: 382 -KDREKYSQREQERDRQQNDQNRPSEK--GEKEEKSKAKEEHMKVRKERY-ENNDKYRDR 437
+++E+ + ++E+ R+Q + + E+ GE+EEK +EE M+ ++E+ +K R++
Sbjct: 587 IREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQ 646
Query: 438 EKREVGVQSSERNQD---RKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSES 494
EK+ + R Q+ +++ ++K +QE KM+ + R +EK E
Sbjct: 647 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE--EKMQEQEEKMRRQEEKMWEQEV 704
Query: 495 SLGAKHRLTEEGQE 508
L + +E QE
Sbjct: 705 RLRQQEEKMQEHQE 718
Score = 83.2 bits (204), Expect = 6e-16
Identities = 102/484 (21%), Positives = 206/484 (42%), Gaps = 55/484 (11%)
Query: 104 IHNLLKAVEIRKKEQEKRMEKKIQRER-----EMEKGEFDDKEAFVTSAYKKKLQERAEE 158
+ L AV +KK+ ++ +E+ + +ER E+ + D+E +A KLQE+ +
Sbjct: 238 LEQALSAVATQKKKADRYIEE-LTKERDALSLELYRNTITDEELKEKNA---KLQEKLQL 293
Query: 159 EEREKRAAAL---------EACLDVTKQKDLSGFYRHL----------LNQAVGEEEVPK 199
E EK L E + Q+ L HL L V E E+
Sbjct: 294 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 353
Query: 200 C--SFREARSGIKEEKSRGFSNEVSSKNRI--PQEKCILQTDVKVEENPDADSDFDAKSS 255
+E + +EEK + + ++ + QE+ I + + K+ + + + K
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 413
Query: 256 ADDEI--EETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH 313
+E+ E+ R+E+++ E + + H + E+ + K R
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK----IREQ 469
Query: 314 EKREDQH-----QQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRAR 368
EKR++Q Q+++ R+QE +++ + R + E KR EQE+ R
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 369 DQRERSDRVWKRE----KDREKYSQREQERDRQQNDQNRPSEK-GEKEEKSKAKEEHMKV 423
++ + +W+++ + EK ++E++ RQ+ + EK E+EEK +EE ++
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE 589
Query: 424 RKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKE 483
++E+ ++ + RE+ E+ + E+ +++E K QE+ KMR +
Sbjct: 590 QEEKIREQEE-KIREQEEMTQEQEEKMGEQEEKMCEQEEK----MQEQEEKMRRQEEKIR 644
Query: 484 RNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQ 543
++K E + + + +E +EK EQE + + K +E M ++ + Q
Sbjct: 645 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEKMWEQ 702
Query: 544 MARV 547
R+
Sbjct: 703 EVRL 706
Score = 75.9 bits (185), Expect = 9e-14
Identities = 84/406 (20%), Positives = 179/406 (44%), Gaps = 37/406 (9%)
Query: 40 SVSESLQREAAKKQAMKQ-TKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKD 98
SVS LQ + + + + + + +K ++ + E++ E ++K E K+ ++
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR-EQE 395
Query: 99 RKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEE 158
K + ++ E + + QE+ M +K ++ R E+ ++ +E K QE+ E
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 455
Query: 159 EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFS 218
+E EKR + +Q+ + +R + + E+E K +E + +EEK
Sbjct: 456 QE-EKRQEEEKIREQEKRQEQEAKMWRQ--EEKIREQE-EKIREQEEKMWRQEEKIHEQE 511
Query: 219 NEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEI---------EETRVNCRR 269
+ R QE+ Q + K+ E + + +++I +E +++ +
Sbjct: 512 KIREEEKRQEQEEMWRQEE-KIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE 570
Query: 270 EKVIETPENDFKHH---RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSR 326
EK+ E E ++ R Q EE+ T+ G ++ + Q+++ +
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 630
Query: 327 DQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQ--RERSDRVWKREKDR 384
+QE + R +E R+ K EQE+K R +++ +E+ +++W++E
Sbjct: 631 EQE------------EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE--- 675
Query: 385 EKYSQREQERDRQQNDQNRPSEK-GEKEEKSKAKEEHMKVRKERYE 429
EK ++E++ Q+ R EK E+E + + +EE M+ +E E
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 84.7 bits (208), Expect = 2e-16
Identities = 72/301 (23%), Positives = 143/301 (47%), Gaps = 25/301 (8%)
Query: 258 DEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKRE 317
++++ T VN R+ +++E R +++SRS S R S H++ SR+ G K
Sbjct: 158 EKLDGTEVNGRKIRLVEDKPGS---RRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSK-- 212
Query: 318 DQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRV 377
H + +SR R + R R R S S + E+ P R RS
Sbjct: 213 SSHSKSRSRS-------RSGSRSRSKSRSRSQSRSRS---KKEKSRSPSKEKSRSRSHSA 262
Query: 378 WK-REKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRD 436
K R K +++ ++ Q D ++R + + + KS+++ + +V +E+ + + R
Sbjct: 263 GKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRS 322
Query: 437 REK--REVGVQSSERNQDRKESSPNSRAKDKFLDQERS---NKMRNMAKDK-ERNQEKPS 490
+EK R+ +S + R S S++KDK ++RS ++ R+ ++ K ER++++ S
Sbjct: 323 QEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGS 382
Query: 491 NSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAK 550
+S G+ + +E ++ + + P +VSK +R + ++ S R+ + A N +
Sbjct: 383 KRDSKAGSSKKKKKEDTDRSQSRS-PSRSVSK--EREHAKSESSQREGRGESENAGTNQE 439
Query: 551 T 551
T
Sbjct: 440 T 440
Score = 68.2 bits (165), Expect = 2e-11
Identities = 63/293 (21%), Positives = 122/293 (41%), Gaps = 14/293 (4%)
Query: 210 KEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRR 269
++ +SR S++ S + + ++ K + S + S E++R
Sbjct: 202 RKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHS 261
Query: 270 EKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQE 329
+ D + QN+ + +RH +K SR E+R + ++K+
Sbjct: 262 AGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVE--EEKRGSVSR 319
Query: 330 NHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQ 389
++ R+ R R + S S R + +DK + R + R R + R K S+
Sbjct: 320 GRSQEKSLRQSRSRSRSKGGSRSRSR-SRSKSKDKRKGRKRSREESR--SRSRSRSK-SE 375
Query: 390 REQERDRQQNDQNRPSEKGEKE--EKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSS 447
R ++R +++ + S+K +KE ++S+++ V KER + RE R +
Sbjct: 376 RSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAG 435
Query: 448 ERNQDRKESSPNSRAKDKFLDQERS-----NKMRNMAKDKERNQEK-PSNSES 494
+ R S NS++K + RS +K R+ +K + R+ + PS S S
Sbjct: 436 TNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRS 488
Score = 64.7 bits (156), Expect = 2e-10
Identities = 66/276 (23%), Positives = 116/276 (42%), Gaps = 23/276 (8%)
Query: 205 ARSGIKEE-KSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEET 263
+RSG + KSR S S++R +EK ++ K + + S ++S + D+ EE
Sbjct: 222 SRSGSRSRSKSRSRSQ---SRSRSKKEKS--RSPSKEKSRSRSHSAGKSRSKSKDQAEEK 276
Query: 264 RVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQK 323
N + V + H+S++ SRS S+ER SR R EK Q + +
Sbjct: 277 IQN--NDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSR-GRSQEKSLRQSRSR 333
Query: 324 QSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKD 383
+ R K +D + R+ S R E + R+R + ERS + +
Sbjct: 334 SRSKGGSRSRSRSRSKSKDKRKGRKRS-------REESRSRSRSRSKSERSRKRGSKRDS 386
Query: 384 REKYSQREQERDRQQNDQNRPSEKGEKE-EKSKAKEEHMKVRKE------RYENNDKYRD 436
+ S+++++ D ++ PS KE E +K++ + R E E + R
Sbjct: 387 KAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRS 446
Query: 437 REKREVGVQSSERNQDRKESSPNSRAKDKFLDQERS 472
K + + S R++ + S SR+K + RS
Sbjct: 447 NSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRS 482
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/533 (21%), Positives = 217/533 (40%), Gaps = 60/533 (11%)
Query: 38 ETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGK 97
+ + SE L ++ K + K + QK + I DE EN+ L
Sbjct: 561 DNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM 620
Query: 98 DRKPKYIHNLLKAVEIRKKEQEKRMEKK-IQREREMEKGEFDDKEA-----FVTSAYKKK 151
D++ K LK +++ KE+EK KK I+ E+E K + KE F +K+
Sbjct: 621 DKEGK----TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKEN 676
Query: 152 LQERAEEE------EREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREA 205
+ E E E E ++ L+ + D S +H+ + +F+E
Sbjct: 677 FFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKER---------NFKEE 727
Query: 206 RSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVE-ENPDADSDFDAKSSADDEIEET- 263
R IK+E + F E D+K E EN D D + S IEE+
Sbjct: 728 RDKIKKESEKSFREEKIK-------------DLKEERENIPTDKDSEFTSLGMSAIEESI 774
Query: 264 -RVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
+E IE E K + + RS +E+ +T +K + +H+
Sbjct: 775 GLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER----KTFEKEKKIKHEHKS 830
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRH-----EQEDKPRARDQRERSDRV 377
++ + + D+ K++ H E H++ ++ + +D+ ++R++ +R
Sbjct: 831 EKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDK 890
Query: 378 WKREKDREKYSQREQ---ERDRQQNDQNR--PSEKGEKEEKSKAKEEHMKVRKERYEN-- 430
K EK+R +E+ E+ +Q+D + SEKG+ +EK + ++ K R + N
Sbjct: 891 EKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINIT 950
Query: 431 NDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPS 490
N K+ EK+ + + Q K S + KD+ L + KD +R +E+
Sbjct: 951 NSKHIQEEKKS-SIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK 1009
Query: 491 NSES-SLGAKHRLTEEGQE-KGKEQERPPEAVSKFAKRNNEETVMSARDRYLA 541
+ + + + +L E + K K + K + N++ + ++ +R L+
Sbjct: 1010 HKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLS 1062
Score = 80.1 bits (196), Expect = 5e-15
Identities = 104/486 (21%), Positives = 217/486 (44%), Gaps = 50/486 (10%)
Query: 74 EYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRM-EKKIQREREM 132
E++S+ E + K E+N K++ N + + KKE EK E+KI+ +E
Sbjct: 691 EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEE 750
Query: 133 EKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAV 192
+ DK++ TS ++E EK +D+ KQ+ +H+
Sbjct: 751 RENIPTDKDSEFTSLGMSAIEESIGLHLVEKE-------IDIEKQE------KHIKES-- 795
Query: 193 GEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFD- 251
+E P+ + I++ + + F E K+ EK L V++ + D +
Sbjct: 796 --KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSH 853
Query: 252 -----------AKSSA----DDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEER 296
+K++A D+ E++R R+ E PE + H +++ + E++
Sbjct: 854 HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKE--RHLAESKEKHLMEKK 911
Query: 297 GHSTRHHTKGSRTSRGHEKREDQHQQKQ--SRDQE--NHYTDRDYRKERDSH--RHREAS 350
+ +++ S++ +G K +D+ K+ SRD+E N + ++E+ S +A
Sbjct: 912 NKQS-DNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 970
Query: 351 HRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQ--NRPSEKG 408
H + + +D+P + D K++KD ++Y +R++ +D+ Q + SE
Sbjct: 971 HEKPLSLKEKTKDEPLKTPDGKEKD---KKDKDIDRYKERDKHKDKIQINSLLKLKSEAD 1027
Query: 409 EKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLD 468
+ + KS + + +++R N+D + +R + ++ E Q K+ + K+K
Sbjct: 1028 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1087
Query: 469 QERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNN 528
+ R N + KDKE+ + P+ S++ + + +E KE++ P +AVS ++ +
Sbjct: 1088 RNR-NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ-PKDAVSNRSQSVD 1145
Query: 529 EETVMS 534
+ VM+
Sbjct: 1146 TKNVMT 1151
Score = 54.7 bits (130), Expect = 2e-07
Identities = 79/450 (17%), Positives = 176/450 (39%), Gaps = 63/450 (14%)
Query: 36 DDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLL 95
DD+++ + + +E K+ + K E +K+ E+ + + + + K+ L +
Sbjct: 709 DDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK-IKDLKEERENIPTDKDSEFTSLGM 767
Query: 96 GKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQER 155
+ +H + K ++I K+E+ + K+ +R K + +K T +KK++
Sbjct: 768 SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH- 826
Query: 156 AEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSR 215
E + EK L C+D K+KD Y H + E E K + ++ +E KSR
Sbjct: 827 --EHKSEKDKLDLSECVDKIKEKDK--LYSHHTEKCHKEGEKSKNTAAIKKTDDRE-KSR 881
Query: 216 GFSNEVSSKNRIPQEKCILQTDVK---VEENPDADSDFDAKSSADDEIEETRVNCRREKV 272
+ K + +E+ + ++ K ++N +D+ +KS E+ R ++EK
Sbjct: 882 EKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKS 941
Query: 273 IETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHY 332
+ + + + + S G+ +H S + +++ + ++++
Sbjct: 942 RDKESINITNSKHIQEEKKSSIVDGNKAQHEKP---LSLKEKTKDEPLKTPDGKEKDKKD 998
Query: 333 TDRDYRKERDSHR----------------------------------------------H 346
D D KERD H+
Sbjct: 999 KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE 1058
Query: 347 REASHRD---SHW-KRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQN 402
R S +D W K+H+++ K + +++ + + + KD+EK E ++ ++
Sbjct: 1059 RMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRS 1118
Query: 403 RPSEKGEKEEKSKAKEEHMKVRKERYENND 432
+ SE + K K ++ + R + + +
Sbjct: 1119 KSSEVTDAYTKEKQPKDAVSNRSQSVDTKN 1148
Score = 29.6 bits (65), Expect = 7.6
Identities = 40/215 (18%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 351 HRDSHWKRHEQEDKPRARDQRERSDRVWKRE----KDREKYSQREQERDRQQN--DQNRP 404
H + ++ ++ ++P + E + + KRE D E Y+ E+ + + D+N
Sbjct: 250 HGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENID 309
Query: 405 SEKGEKEEKSKAKE-----EHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPN 459
SE + ++K+ + + YE D + + + + R + RKE+ P
Sbjct: 310 SETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 369
Query: 460 SRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEA 519
+ F QE++ ++ K +KPS + TE E+ + ++ +
Sbjct: 370 AEKTHLFAKQEKAFYPKSFKSKK----QKPSR------VLYSSTESSDEEALQNKKISTS 419
Query: 520 VSKFAKRNNEETVMSARDRYLA----RQMARVNAK 550
S + +N + M + Y+ +Q +V K
Sbjct: 420 CSVIPETSNSD--MQTKKEYVVSGEHKQKGKVKRK 452
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/533 (21%), Positives = 217/533 (40%), Gaps = 60/533 (11%)
Query: 38 ETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGK 97
+ + SE L ++ K + K + QK + I DE EN+ L
Sbjct: 584 DNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM 643
Query: 98 DRKPKYIHNLLKAVEIRKKEQEKRMEKK-IQREREMEKGEFDDKEA-----FVTSAYKKK 151
D++ K LK +++ KE+EK KK I+ E+E K + KE F +K+
Sbjct: 644 DKEGK----TLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKEN 699
Query: 152 LQERAEEE------EREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREA 205
+ E E E E ++ L+ + D S +H+ + +F+E
Sbjct: 700 FFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKER---------NFKEE 750
Query: 206 RSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVE-ENPDADSDFDAKSSADDEIEET- 263
R IK+E + F E D+K E EN D D + S IEE+
Sbjct: 751 RDKIKKESEKSFREEKIK-------------DLKEERENIPTDKDSEFTSLGMSAIEESI 797
Query: 264 -RVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQ 322
+E IE E K + + RS +E+ +T +K + +H+
Sbjct: 798 GLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER----KTFEKEKKIKHEHKS 853
Query: 323 KQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRH-----EQEDKPRARDQRERSDRV 377
++ + + D+ K++ H E H++ ++ + +D+ ++R++ +R
Sbjct: 854 EKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDK 913
Query: 378 WKREKDREKYSQREQ---ERDRQQNDQNR--PSEKGEKEEKSKAKEEHMKVRKERYEN-- 430
K EK+R +E+ E+ +Q+D + SEKG+ +EK + ++ K R + N
Sbjct: 914 EKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINIT 973
Query: 431 NDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPS 490
N K+ EK+ + + Q K S + KD+ L + KD +R +E+
Sbjct: 974 NSKHIQEEKKS-SIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDK 1032
Query: 491 NSES-SLGAKHRLTEEGQE-KGKEQERPPEAVSKFAKRNNEETVMSARDRYLA 541
+ + + + +L E + K K + K + N++ + ++ +R L+
Sbjct: 1033 HKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLS 1085
Score = 80.1 bits (196), Expect = 5e-15
Identities = 104/486 (21%), Positives = 217/486 (44%), Gaps = 50/486 (10%)
Query: 74 EYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRM-EKKIQREREM 132
E++S+ E + K E+N K++ N + + KKE EK E+KI+ +E
Sbjct: 714 EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEE 773
Query: 133 EKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAV 192
+ DK++ TS ++E EK +D+ KQ+ +H+
Sbjct: 774 RENIPTDKDSEFTSLGMSAIEESIGLHLVEKE-------IDIEKQE------KHIKES-- 818
Query: 193 GEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFD- 251
+E P+ + I++ + + F E K+ EK L V++ + D +
Sbjct: 819 --KEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSH 876
Query: 252 -----------AKSSA----DDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEER 296
+K++A D+ E++R R+ E PE + H +++ + E++
Sbjct: 877 HTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKE--RHLAESKEKHLMEKK 934
Query: 297 GHSTRHHTKGSRTSRGHEKREDQHQQKQ--SRDQE--NHYTDRDYRKERDSH--RHREAS 350
+ +++ S++ +G K +D+ K+ SRD+E N + ++E+ S +A
Sbjct: 935 NKQS-DNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 993
Query: 351 HRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQ--NRPSEKG 408
H + + +D+P + D K++KD ++Y +R++ +D+ Q + SE
Sbjct: 994 HEKPLSLKEKTKDEPLKTPDGKEKD---KKDKDIDRYKERDKHKDKIQINSLLKLKSEAD 1050
Query: 409 EKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLD 468
+ + KS + + +++R N+D + +R + ++ E Q K+ + K+K
Sbjct: 1051 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1110
Query: 469 QERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNN 528
+ R N + KDKE+ + P+ S++ + + +E KE++ P +AVS ++ +
Sbjct: 1111 RNR-NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ-PKDAVSNRSQSVD 1168
Query: 529 EETVMS 534
+ VM+
Sbjct: 1169 TKNVMT 1174
Score = 54.7 bits (130), Expect = 2e-07
Identities = 79/450 (17%), Positives = 176/450 (39%), Gaps = 63/450 (14%)
Query: 36 DDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLL 95
DD+++ + + +E K+ + K E +K+ E+ + + + + K+ L +
Sbjct: 732 DDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK-IKDLKEERENIPTDKDSEFTSLGM 790
Query: 96 GKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQER 155
+ +H + K ++I K+E+ + K+ +R K + +K T +KK++
Sbjct: 791 SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH- 849
Query: 156 AEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSR 215
E + EK L C+D K+KD Y H + E E K + ++ +E KSR
Sbjct: 850 --EHKSEKDKLDLSECVDKIKEKDK--LYSHHTEKCHKEGEKSKNTAAIKKTDDRE-KSR 904
Query: 216 GFSNEVSSKNRIPQEKCILQTDVK---VEENPDADSDFDAKSSADDEIEETRVNCRREKV 272
+ K + +E+ + ++ K ++N +D+ +KS E+ R ++EK
Sbjct: 905 EKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKS 964
Query: 273 IETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHY 332
+ + + + + S G+ +H S + +++ + ++++
Sbjct: 965 RDKESINITNSKHIQEEKKSSIVDGNKAQHEKP---LSLKEKTKDEPLKTPDGKEKDKKD 1021
Query: 333 TDRDYRKERDSHR----------------------------------------------H 346
D D KERD H+
Sbjct: 1022 KDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFE 1081
Query: 347 REASHRD---SHW-KRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQN 402
R S +D W K+H+++ K + +++ + + + KD+EK E ++ ++
Sbjct: 1082 RMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRS 1141
Query: 403 RPSEKGEKEEKSKAKEEHMKVRKERYENND 432
+ SE + K K ++ + R + + +
Sbjct: 1142 KSSEVTDAYTKEKQPKDAVSNRSQSVDTKN 1171
Score = 29.6 bits (65), Expect = 7.6
Identities = 40/215 (18%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 351 HRDSHWKRHEQEDKPRARDQRERSDRVWKRE----KDREKYSQREQERDRQQN--DQNRP 404
H + ++ ++ ++P + E + + KRE D E Y+ E+ + + D+N
Sbjct: 273 HGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENID 332
Query: 405 SEKGEKEEKSKAKE-----EHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPN 459
SE + ++K+ + + YE D + + + + R + RKE+ P
Sbjct: 333 SETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
Query: 460 SRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEA 519
+ F QE++ ++ K +KPS + TE E+ + ++ +
Sbjct: 393 AEKTHLFAKQEKAFYPKSFKSKK----QKPSR------VLYSSTESSDEEALQNKKISTS 442
Query: 520 VSKFAKRNNEETVMSARDRYLA----RQMARVNAK 550
S + +N + M + Y+ +Q +V K
Sbjct: 443 CSVIPETSNSD--MQTKKEYVVSGEHKQKGKVKRK 475
>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
sapiens]
Length = 434
Score = 84.3 bits (207), Expect = 3e-16
Identities = 80/334 (23%), Positives = 132/334 (39%), Gaps = 51/334 (15%)
Query: 246 ADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRS-------PSEERGH 298
A SD + A ++ R + + + KHH S++ SRS +E R H
Sbjct: 2 AASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKH 61
Query: 299 STRHHTKGSRTSRGHEKREDQHQQKQSRDQEN-------------HYTDRDYRKERDSHR 345
+R +K R +K +H+ ++ D+E+ + DR RKER S R
Sbjct: 62 RSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSR 121
Query: 346 HREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPS 405
R S S +RH + R + + +R R + RE+ R + R+R++ ++R
Sbjct: 122 GRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSR-- 179
Query: 406 EKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDK 465
S+++ H + R + RDR+KR + R+ R S P R ++
Sbjct: 180 --------SRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNT 231
Query: 466 FLD-QERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFA 524
+D QE + AK + +EK E EK K+QE A + +
Sbjct: 232 AMDAQEALARRLERAKKLQEQREK----------------EMVEKQKQQEIAAAAATGGS 275
Query: 525 KRNNEETVMSAR----DRYLARQMARVNAKTYIE 554
N + S +A QMA + AK E
Sbjct: 276 VLNVAALLASGTQVTPQIAMAAQMAALQAKALAE 309
Score = 47.4 bits (111), Expect = 4e-05
Identities = 48/212 (22%), Positives = 89/212 (41%), Gaps = 30/212 (14%)
Query: 357 KRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKA 416
K DK + + + S R K R + R +ER R+ +++ R + +S++
Sbjct: 15 KTSPDRDKKKEQSEVSVSPRASKHHYSRSR--SRSRERKRKSDNEGR-----KHRSRSRS 67
Query: 417 KEEHMKVRKERYENNDK---------YRDRE----KREVGVQSSERNQDRKESSPNSRAK 463
KE R+E+ DK + D+E K + SSE +DR + ++
Sbjct: 68 KEGR------RHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSR 121
Query: 464 DKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKF 523
+ + RS + R+ ++ +ER + + S S ++ R E + + + +ER S+
Sbjct: 122 GRSHSRSRSRERRHRSRSRERKKSR-SRSRERKKSRSRSRERKKSRSRSRERKRRIRSRS 180
Query: 524 AKRNNEETVMSARDRYLARQMARVNAKTYIEK 555
R+ +R R +R R K IEK
Sbjct: 181 RSRSRHRHRTRSRSRTRSRSRDR---KKRIEK 209
Score = 33.9 bits (76), Expect = 0.40
Identities = 63/292 (21%), Positives = 110/292 (37%), Gaps = 52/292 (17%)
Query: 85 KKEENNPKLLLGKDRKPKYIHNLLKAVEI-RKKEQEKRMEKKIQREREMEKGEFDDKEAF 143
KK+E + + + K Y + ++ E RK + E R + R +E + E DK
Sbjct: 22 KKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDK--- 78
Query: 144 VTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFR 203
S+ K K +E ++E + R LN + E+ K R
Sbjct: 79 --SSKKHKSEEHNDKEHSSDKG-------------------RERLNSSENGEDRHKRKER 117
Query: 204 EARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEET 263
++ G +SR S E ++R + K S E +++
Sbjct: 118 KSSRGRSHSRSR--SRERRHRSRSRERK--------------------KSRSRSRERKKS 155
Query: 264 RVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQK 323
R R K + + K R ++ SRS S R H TR ++ SR +KR ++ ++
Sbjct: 156 RSRSRERKKSRSRSRERK-RRIRSRSRSRSRHR-HRTRSRSRTRSRSRDRKKRIEK-PRR 212
Query: 324 QSRDQENHYTDRDYRKERDSHRHREASHR--DSHWKRHEQEDKPRARDQRER 373
SR + +R + +EA R + K EQ +K Q+++
Sbjct: 213 FSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQ 264
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 84.0 bits (206), Expect = 3e-16
Identities = 46/180 (25%), Positives = 97/180 (53%), Gaps = 4/180 (2%)
Query: 277 ENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRD-QENHYTDR 335
E++ K R + R E+ K + + E+ +++ ++++ R+ Q ++
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 336 DYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERD 395
+ RK + + RE R ++ ++E K R R+ ++R +R KR+K R+K ++E++R+
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRER--KRKKRRKKKRRKERKRE 150
Query: 396 RQQNDQNRPSEKGEKEEKSKAKEEHMKVR-KERYENNDKYRDREKREVGVQSSERNQDRK 454
+++ + R +K +KEE+ K +E + K R KER + R +E+++ + ER +DRK
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRK 210
Score = 82.4 bits (202), Expect = 1e-15
Identities = 50/212 (23%), Positives = 106/212 (50%), Gaps = 13/212 (6%)
Query: 285 SQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSH 344
S +H P +R K R R KRE + ++K+ R ++ ++ RK+R+
Sbjct: 21 SCSHISKPCTQR----ESERKKERREREKRKREREKERKRERGKK----EKKKRKKRERG 72
Query: 345 RHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRP 404
+ RE ++ +R E+ +K R + ++E+ R K+ RE+ ++E++ ++N Q R
Sbjct: 73 KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRR- 131
Query: 405 SEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKD 464
E++ K + K++ K RK E + R R+KR+ + +R ++RKE K+
Sbjct: 132 ----ERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKE 187
Query: 465 KFLDQERSNKMRNMAKDKERNQEKPSNSESSL 496
+ ++ K R K+++++++ ++S +
Sbjct: 188 RRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
Score = 82.0 bits (201), Expect = 1e-15
Identities = 46/207 (22%), Positives = 103/207 (49%), Gaps = 11/207 (5%)
Query: 285 SQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSH 344
+Q S E R R + R K+E + ++K+ R +E ++ K+R
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 345 RHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQER-----DRQQN 399
R +E R K+ E++ + R RER + ++E++RE +RE++R +++
Sbjct: 90 REKERRKRKKEKKKRERKQRGR----RERKKKKERKERERENKQRRERKRKKRRKKKRRK 145
Query: 400 DQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPN 459
++ R E+G++E K K +++ + +K ++ ++RE++E + ER ++R++
Sbjct: 146 ERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK--K 203
Query: 460 SRAKDKFLDQERSNKMRNMAKDKERNQ 486
R KD+ D++ +++ ++ N+
Sbjct: 204 ERKKDRKTDRQTDSQVFRPLRESAFNR 230
Score = 80.5 bits (197), Expect = 4e-15
Identities = 45/189 (23%), Positives = 88/189 (46%), Gaps = 2/189 (1%)
Query: 252 AKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSR 311
+K E E + REK E + K R + + + R + R +
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 312 GHEKREDQH--QQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARD 369
E+RE + ++K+ + +E R RK++ + RE ++ ++ ++ K + R
Sbjct: 86 RKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRK 145
Query: 370 QRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYE 429
+R+R KRE+ R+K + E+E+ R++N + R E+ KE + + KE + RK++
Sbjct: 146 ERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKER 205
Query: 430 NNDKYRDRE 438
D+ DR+
Sbjct: 206 KKDRKTDRQ 214
Score = 80.1 bits (196), Expect = 5e-15
Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 2/175 (1%)
Query: 343 SHRHREASHRDSHWKRHEQEDKPRARD-QRERSDRVWKREKDREKYSQREQERDRQQNDQ 401
SH + + R+S K+ +E + R R+ ++ER K+EK + K +R +ER+R++ ++
Sbjct: 23 SHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKER 82
Query: 402 NRP-SEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNS 460
+ E+ EKE + + KE+ + RK+R K + K R + RK+
Sbjct: 83 EKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKK 142
Query: 461 RAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515
R K++ ++ER + R K K+ +EK K R +E +E+ KE+++
Sbjct: 143 RRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKK 197
Score = 75.9 bits (185), Expect = 9e-14
Identities = 43/179 (24%), Positives = 92/179 (51%), Gaps = 6/179 (3%)
Query: 338 RKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQ 397
RK+ R + R+ KR + + + R +RER ++ K+REK QR++ R+++
Sbjct: 36 RKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREK--QRKERREKE 93
Query: 398 QNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDR-KES 456
+ + + +K E++++ + + + K RKER N + R+R++++ + + + R KE
Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER 153
Query: 457 SPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515
R + K +ER K K++++ +E+ E K R E ++K ++++R
Sbjct: 154 GKRERKRKKRKKEEREKKRERNRKERKKERERKERRERK---KERKKERRKKKERKKDR 209
Score = 71.6 bits (174), Expect = 2e-12
Identities = 52/184 (28%), Positives = 97/184 (52%), Gaps = 15/184 (8%)
Query: 379 KREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMK----VRKERYENNDKY 434
+RE +R+K +RE+E+ +++ ++ R E+G+KE+K + K E K RKER + +
Sbjct: 31 QRESERKK-ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 435 RDREKREVGVQSSERNQDRKESSPNSRAKDK-FLDQERSNKMRNMAKDKERNQEKPSNSE 493
R++E+R+ + ++ ++RK+ R K K ++ER NK R K K+R ++K
Sbjct: 90 REKERRK--RKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE- 146
Query: 494 SSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYI 553
+ R E G+ + K ++R E K +RN +E R+R R+ + K
Sbjct: 147 -----RKREKERGKRERKRKKRKKEEREKKRERNRKER-KKERERKERRERKKERKKERR 200
Query: 554 EKED 557
+K++
Sbjct: 201 KKKE 204
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/152 (21%), Positives = 73/152 (48%), Gaps = 15/152 (9%)
Query: 253 KSSADDEIEETRVNCRREKVIETPENDFKHH-RSQNHSRSPSEERGHSTRHHTKGSRTSR 311
+ + + +E R RR++ E + + K R + + +ER + + R R
Sbjct: 79 RKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR 138
Query: 312 GHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQR 371
+KR + ++++ R + + ++ER+ R R ++++ + R+++
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKRER------------NRKERKKERERK 186
Query: 372 ERSDRVWKREKDREKYSQREQER--DRQQNDQ 401
ER +R +R+K+R K +R+++R DRQ + Q
Sbjct: 187 ERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 42.0 bits (97), Expect = 0.001
Identities = 46/195 (23%), Positives = 82/195 (42%), Gaps = 6/195 (3%)
Query: 46 QREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIH 105
QRE+ +K+ ++ E +K E E + +KK+E + K+R+ +
Sbjct: 31 QRESERKKERRER--EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKE 88
Query: 106 NLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRA 165
K RKKE++KR K+ R +K E ++E ++K ++R +++ R++R
Sbjct: 89 RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 166 AALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKN 225
E K+K R + +E + +E R KE K + K+
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKD 208
Query: 226 RIPQEKCILQTDVKV 240
R K QTD +V
Sbjct: 209 R----KTDRQTDSQV 219
Score = 41.2 bits (95), Expect = 0.003
Identities = 29/129 (22%), Positives = 53/129 (41%), Gaps = 4/129 (3%)
Query: 414 SKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDR---KESSPNSRAKDKFLDQE 470
++ + E K R+ER + + KRE G + ++ + R KE + ++K +
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 471 RSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEK-GKEQERPPEAVSKFAKRNNE 529
R + R K+K++ + K K R E + K +E++R K K
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR 149
Query: 530 ETVMSARDR 538
E R+R
Sbjct: 150 EKERGKRER 158
Score = 32.7 bits (73), Expect = 0.90
Identities = 26/127 (20%), Positives = 65/127 (51%), Gaps = 8/127 (6%)
Query: 38 ETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGK 97
E E +R+ KK+ ++ + ++ ++ E ++ +K+K+ K +
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKER 147
Query: 98 DRKPKYIHNLLKAVEIRKKEQEKRMEK-KIQREREMEKGEFDDKEAFVTSAYKKKLQERA 156
R+ + K + +K+E+EK+ E+ + +R++E E+ E +++ K++ +ER
Sbjct: 148 KREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERK-------KERKKERR 200
Query: 157 EEEEREK 163
+++ER+K
Sbjct: 201 KKKERKK 207
Score = 32.7 bits (73), Expect = 0.90
Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 12/101 (11%)
Query: 43 ESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPK 102
E +++ KK+ K+ K E ++ E +E +KK+E N + ++RK +
Sbjct: 132 ERKRKKRRKKKRRKERKREKERGKRERKRKKRKK---EEREKKRERNRKERKKERERKER 188
Query: 103 YIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAF 143
RKKE++K KK +R+++ + D + F
Sbjct: 189 ---------RERKKERKKERRKKKERKKDRKTDRQTDSQVF 220
Score = 32.3 bits (72), Expect = 1.2
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 456 SSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515
S P ++ + + + R + R ++KER +E+ G K + + +E+GKE+ER
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRER--------GKKEKKKRKKRERGKERER 77
Query: 516 PPEAVSKFAKRNNEE 530
+ K K E+
Sbjct: 78 KRKEREKQRKERREK 92
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 84.0 bits (206), Expect = 3e-16
Identities = 92/421 (21%), Positives = 193/421 (45%), Gaps = 45/421 (10%)
Query: 104 IHNLLKAVEIRKKEQEKRMEKKIQRER-----EMEKGEFDDKEAFVTSAYKKKLQERAEE 158
+ L AV +KK+ ++ +E+ + +ER E+ + D+E +A KLQE+ +
Sbjct: 165 LEQALSAVATQKKKADRYIEE-LTKERDALSLELYRNTITDEELKEKNA---KLQEKLQL 220
Query: 159 EEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFS 218
E EK E L+V + K + LL Q + E +E +S + +++
Sbjct: 221 VESEKS----EIQLNVKELKRKLERAKLLLPQQQLQAEADHLG-KELQSVSAKLQAQVEE 275
Query: 219 NEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPEN 278
NE+ ++ QE+ + + + K++E E ++ + EK+ E E
Sbjct: 276 NELWNRLNQQQEEKMWRQEEKIQER------------------EEKIQEQEEKIREQEEK 317
Query: 279 DFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYR 338
R Q EE+ + + + E E H+Q++ R+QE + +
Sbjct: 318 ----MRRQEEMMWEKEEKMRR-QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372
Query: 339 KERDSHRHREASHRDSHWKRHEQEDKPRARDQ--RERSDRVWKREK---DREKYSQREQE 393
+E++ + +EA K EQE+K R +++ +E+ +++ ++E+ ++E+ Q ++E
Sbjct: 373 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEE 432
Query: 394 RDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDR 453
+ R+Q ++ R EK +E++ K +E+ ++++ + ++ ++E +Q E R
Sbjct: 433 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
Query: 454 KESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQ 513
+E + K K +QE K+R + + +EK E + + +E +EK + Q
Sbjct: 493 QEEKIREQEK-KIREQE--EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 549
Query: 514 E 514
E
Sbjct: 550 E 550
Score = 67.0 bits (162), Expect = 4e-11
Identities = 54/235 (22%), Positives = 110/235 (46%), Gaps = 14/235 (5%)
Query: 316 REDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSD 375
R +Q Q+++ QE +R+ + + + RE ++ +R E+ + R + +
Sbjct: 281 RLNQQQEEKMWRQEEKIQEREEKIQEQEEKIRE---QEEKMRRQEEMMWEKEEKMRRQEE 337
Query: 376 RVW-KREKDRE-KYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERY-ENND 432
+W K EK RE + EQE+ R+Q ++ + EK ++EK + +E M ++E+ E +
Sbjct: 338 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 397
Query: 433 KYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNS 492
K R++E+ +Q E +E + ++ QE+ KMR + ++K
Sbjct: 398 KIREQEEM---MQEQEEKMGEQEEKMWEQEEEM---QEQEEKMRRQEEKIREQEKKIREQ 451
Query: 493 ESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARV 547
E + + + +E +EK EQE + + AK +E M ++ + Q ++
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQE--GKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504
Score = 60.8 bits (146), Expect = 3e-09
Identities = 80/410 (19%), Positives = 181/410 (44%), Gaps = 47/410 (11%)
Query: 51 KKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKA 110
KK+A + + ++ A +Y +E+++K + KL L + K +
Sbjct: 176 KKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSE-------- 227
Query: 111 VEIRKKEQEKRMEK-KIQREREMEKGEFDD--KEAFVTSAYKKKLQERAEEEE------- 160
+++ KE ++++E+ K+ ++ + E D KE SA KLQ + EE E
Sbjct: 228 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA---KLQAQVEENELWNRLNQ 284
Query: 161 --------REKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEE 212
+E++ E + ++K + + + E+ K +E KEE
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 344
Query: 213 KSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKV 272
K R ++ + +I +++ Q + K+ E + + +AK +E ++ + EK+
Sbjct: 345 KIRELEEKMHEQEKIREQEEKRQEEEKIREQ-EKRQEQEAKMWRQEE----KIREQEEKI 399
Query: 273 IETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHY 332
E E + Q EE+ + ++ + + Q+K+ R+QE
Sbjct: 400 REQEEM----MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKI 455
Query: 333 TDRD--YRKERDSHRHREASHRDSHWKRHEQEDKPRARDQ--RERSDRVWKRE---KDRE 385
+++ +++ + +E + K EQE+K R +++ RE+ ++ ++E +++E
Sbjct: 456 REQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 515
Query: 386 KYSQREQERDRQQNDQNRPSEKG--EKEEKSKAKEEHMKVRKERYENNDK 433
+ Q ++E+ +Q ++ E+ E+EEK + +EE M+ ++ R ++
Sbjct: 516 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565
Score = 37.4 bits (85), Expect = 0.037
Identities = 27/122 (22%), Positives = 59/122 (48%), Gaps = 2/122 (1%)
Query: 43 ESLQREAAKKQAMKQTKLEIQKALAE-DATVYEYDSIYDEMQKKKEENNPKLLLGKDRKP 101
E +Q + K + ++ E +K + E + + E + + E ++K E K+ ++ K
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC-EQEAKM 483
Query: 102 KYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEER 161
+ ++ E + +EQEK++ ++ ++ RE E+ + +E K QE +E+
Sbjct: 484 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 543
Query: 162 EK 163
EK
Sbjct: 544 EK 545
Score = 36.2 bits (82), Expect = 0.081
Identities = 46/223 (20%), Positives = 99/223 (44%), Gaps = 27/223 (12%)
Query: 35 DDDETSVSESLQREAAKKQAMKQTKLEIQKALAE-DATVYEYDSIYDEMQKKKEENNPKL 93
+ +E E RE K+Q + ++ + E + + E + + E ++K E K+
Sbjct: 361 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420
Query: 94 LLGKDRKPKYIHNLLKAVEIRKKEQEKRM---EKKIQREREM----------EKGEFDDK 140
++ + + + E + +EQEK++ E+KI+ + EM ++G+ ++
Sbjct: 421 WEQEEEMQEQEEKMRRQEE-KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ 479
Query: 141 EAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKC 200
EA + +K R EE+ RE+ E + +Q+++ + + E+E C
Sbjct: 480 EAKMQEQEEK--MRRQEEKIREQEKKIREQEEKIREQEEM----MQEQEEKMWEQEEKMC 533
Query: 201 SFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEEN 243
+E + +EEK R ++ QE + Q + K++E+
Sbjct: 534 E-QEEKMQEQEEKMRRQEEKMRE-----QEVRLRQQEEKMQEH 570
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 82.0 bits (201), Expect = 1e-15
Identities = 62/218 (28%), Positives = 109/218 (50%), Gaps = 36/218 (16%)
Query: 284 RSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDS 343
R + R +R + H + R E +D+ +Q++ + + DRD ++ER
Sbjct: 58 RERERQRERERQRKRAKERHREKDR-----EIEKDRDRQRKRDRERQRWRDRDRKRERWG 112
Query: 344 HRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQRE--QERDRQ---Q 398
R RE + QE++ R RD+ KREKDRE+ QRE ++DR+ +
Sbjct: 113 DRDRET-------ETERQEERERQRDR--------KREKDRERQRQREIGIDKDREIETE 157
Query: 399 NDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSP 458
D++R E GE E + E K R+ R + D+ R REK + ER++DR++
Sbjct: 158 KDRDREREMGETERYRDRERERQKQRETR-RDRDRERQREK-----EDRERDRDRQK--- 208
Query: 459 NSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSL 496
R KD++ ++E + + R+ +D+ER +EK + + ++
Sbjct: 209 -EREKDRYRERE-TGRDRDKERDRERQREKDRDRQKAI 244
Score = 80.9 bits (198), Expect = 3e-15
Identities = 50/203 (24%), Positives = 108/203 (53%), Gaps = 10/203 (4%)
Query: 339 KERDSHRHREASHRDSHWKRHEQEDKP--RARDQRERSDRVWKREKDREKYSQREQERDR 396
+ER+ R RE + + +RH ++D+ + RD++ + DR +R +DR++ +R +RDR
Sbjct: 58 RERERQRERERQRKRAK-ERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDR 116
Query: 397 Q-----QNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQ 451
+ Q ++ R ++ ++++ + ++ + + K+R +K RDRE RE+G R++
Sbjct: 117 ETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDRE-REMGETERYRDR 175
Query: 452 DRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGK 511
+R+ +D+ +++R + R +D+++ +EK E G + R E +E+ +
Sbjct: 176 ERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETG-RDRDKERDRERQR 234
Query: 512 EQERPPEAVSKFAKRNNEETVMS 534
E++R + E TVM+
Sbjct: 235 EKDRDRQKAIDCVPGRWEVTVMA 257
Score = 69.3 bits (168), Expect = 9e-12
Identities = 45/193 (23%), Positives = 90/193 (46%), Gaps = 16/193 (8%)
Query: 268 RREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRD 327
+RE+ + +H + + R + R E+ D+ ++ ++
Sbjct: 63 QRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETER 122
Query: 328 QENHYTDRDYRKERDSHRHREAS---HRDSHWKRHEQEDKPRARDQRER-SDRVWKREKD 383
QE RD ++E+D R R+ +D + + D+ R + ER DR +R+K
Sbjct: 123 QEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQ 182
Query: 384 REKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVG 443
RE R++ER R++ D+ R ++ ++ EK + +E +E + DK RDRE++
Sbjct: 183 RETRRDRDRERQREKEDRERDRDRQKEREKDRYRE------RETGRDRDKERDRERQR-- 234
Query: 444 VQSSERNQDRKES 456
E+++DR+++
Sbjct: 235 ----EKDRDRQKA 243
Score = 60.8 bits (146), Expect = 3e-09
Identities = 43/203 (21%), Positives = 93/203 (45%), Gaps = 10/203 (4%)
Query: 347 REASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSE 406
R S R + + E D R R + +RE+ RE+ QR++ ++R + E
Sbjct: 27 RPVSWRLAMRSQIEDRDVLILRGSRVAPAIIRERERQRERERQRKRAKERHR-------E 79
Query: 407 KGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKF 466
K + EK + ++ ++R+ + D+ R+R +ER ++R+ R KD+
Sbjct: 80 KDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDRE 139
Query: 467 LDQERS---NKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKF 523
++R +K R + +K+R++E+ + R ++ +E ++++R + +
Sbjct: 140 RQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKED 199
Query: 524 AKRNNEETVMSARDRYLARQMAR 546
+R+ + +DRY R+ R
Sbjct: 200 RERDRDRQKEREKDRYRERETGR 222
Score = 56.6 bits (135), Expect = 6e-08
Identities = 40/176 (22%), Positives = 85/176 (48%), Gaps = 13/176 (7%)
Query: 241 EENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHST 300
E++ + + D D + D E + R R+ + + + + R + R +R
Sbjct: 79 EKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKR---E 135
Query: 301 RHHTKGSRTSRGHEK-REDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRH 359
+ + + G +K RE + ++ + R++E T+R +ER+ + RE ++
Sbjct: 136 KDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQR 195
Query: 360 EQEDKPRARDQRERSDRVWKREKDREKYSQREQERDR-QQNDQNRPSEKGEKEEKS 414
E+ED+ R RD+ ++E+++++Y +RE RDR ++ D+ R EK +K+
Sbjct: 196 EKEDRERDRDR--------QKEREKDRYRERETGRDRDKERDRERQREKDRDRQKA 243
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/283 (21%), Positives = 111/283 (39%), Gaps = 98/283 (34%)
Query: 116 KEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVT 175
+E+E++ E++ QR+R E+ D+E +K ++R + +RE++
Sbjct: 58 RERERQRERERQRKRAKERHREKDREI-------EKDRDRQRKRDRERQ----------- 99
Query: 176 KQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQ 235
+ +D R + G+ + RE + +EE+ R Q
Sbjct: 100 RWRD-----RDRKRERWGDRD------RETETERQEERER-------------------Q 129
Query: 236 TDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEE 295
D K E++ + + D EIE + R E
Sbjct: 130 RDRKREKDRERQRQREIGIDKDREIETEK------------------------DRDRERE 165
Query: 296 RGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSH 355
G + R+ + + E R D+ +++Q R++E+ DRD +KER+ R+RE
Sbjct: 166 MGETERYRDRERERQKQRETRRDRDRERQ-REKEDRERDRDRQKEREKDRYRE------- 217
Query: 356 WKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQ 398
+ RD R+K+R++ QRE++RDRQ+
Sbjct: 218 --------RETGRD----------RDKERDRERQREKDRDRQK 242
Score = 31.6 bits (70), Expect = 2.0
Identities = 32/143 (22%), Positives = 60/143 (41%), Gaps = 40/143 (27%)
Query: 24 QKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQ 83
Q+ G D D + ET +RE + + + + E QK + T + D E Q
Sbjct: 141 QRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQK---QRETRRDRDR---ERQ 194
Query: 84 KKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAF 143
++KE+ R+++++++ E++ R RE E G DKE
Sbjct: 195 REKED-------------------------RERDRDRQKEREKDRYRERETGRDRDKE-- 227
Query: 144 VTSAYKKKLQERAEEEEREKRAA 166
+ +ER E++R+++ A
Sbjct: 228 -------RDRERQREKDRDRQKA 243
Score = 30.0 bits (66), Expect = 5.8
Identities = 24/102 (23%), Positives = 49/102 (48%), Gaps = 9/102 (8%)
Query: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
+ +E++++ E I ++RE+E + D+E + + + +ER +++RE R D
Sbjct: 136 KDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDR-----D 190
Query: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSR 215
+Q++ R Q +E K +RE +G +K R
Sbjct: 191 RERQREKEDRERDRDRQ----KEREKDRYRERETGRDRDKER 228
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 82.0 bits (201), Expect = 1e-15
Identities = 47/190 (24%), Positives = 96/190 (50%), Gaps = 5/190 (2%)
Query: 329 ENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYS 388
E DR + R++ R R+ + RH + D+ R R++ DR +REK ++
Sbjct: 13 ETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREG 72
Query: 389 QREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENN-DKYRDREKREVGVQSS 447
+R++ER+R ++ Q + +KE ++ E + R+++ E ++ RDRE+ +
Sbjct: 73 ERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGR 132
Query: 448 ERNQDRKESSPNSRA--KDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEE 505
ER DR+ R +++ +ER + R+ +++ER +E+ E+ +H T+
Sbjct: 133 ERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERH--TDM 190
Query: 506 GQEKGKEQER 515
+E+ +E +R
Sbjct: 191 ERERQRETDR 200
Score = 80.9 bits (198), Expect = 3e-15
Identities = 57/214 (26%), Positives = 107/214 (50%), Gaps = 21/214 (9%)
Query: 288 HSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQK-QSRDQE-NHYTDRDYRKE----R 341
H+ + + +R R T R K ED+H ++ + RD+E N DRD +E R
Sbjct: 11 HTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDR 70
Query: 342 DSHRHREASH-RDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQN- 399
+ R RE RD + + DK R D+ +DR +++K+RE R++ER++Q+
Sbjct: 71 EGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEM 130
Query: 400 DQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPN 459
+ R +++ E+ + E + +ER + D++R+RE+ ER ++R E
Sbjct: 131 GRERQTDRETDRERERQAERERETGRER-KTEDRHRERER--------ERKRER-ERKRE 180
Query: 460 SRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSE 493
++ +++ D ER R D++R++++ S E
Sbjct: 181 TKERERHTDMERE---RQRETDRKRDRQRESERE 211
Score = 79.7 bits (195), Expect = 6e-15
Identities = 50/213 (23%), Positives = 104/213 (48%), Gaps = 8/213 (3%)
Query: 304 TKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQED 363
T+G T E + Q ++++ D+E ++R S R R+ RD R D
Sbjct: 5 TEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQ---RDRERNRERDRD 61
Query: 364 KPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKV 423
+ R + +R +RE+DR++ + E+ERD+++ + +R +E + +K K +E
Sbjct: 62 REREKQTDREGERQRERERDRDRQRETERERDKER-ETDRHTETDRERQKQKEREMERVR 120
Query: 424 RKERYENNDKYRDREKREVGVQSSERNQDR-KESSPNSRAKDKFLDQERSNKMRNMAKDK 482
+ER + + R+R+ + ER +R +E+ + +D+ ++ER K K +
Sbjct: 121 DREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRE 180
Query: 483 ERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515
+ +E+ ++ E + R T+ +++ +E ER
Sbjct: 181 TKERERHTDMERE---RQRETDRKRDRQRESER 210
Score = 79.0 bits (193), Expect = 1e-14
Identities = 56/208 (26%), Positives = 98/208 (47%), Gaps = 23/208 (11%)
Query: 261 EETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEK---RE 317
E ++ +RE+ ET + S+ R +R + + R R EK RE
Sbjct: 13 ETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDR-DREREKQTDRE 71
Query: 318 DQHQQKQSRDQENHY-TDRDYRKERDSHRHREASHRDSHWKRHEQE-------DKPRARD 369
+ Q+++ RD++ T+R+ KER++ RH E K E E +K +
Sbjct: 72 GERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMG 131
Query: 370 QRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEK-----SKAKEEHMKVR 424
+ ++DR RE++R+ +RE R+R+ D++R E+ K E+ +K +E H +
Sbjct: 132 RERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDME 191
Query: 425 KERYENNDKYRDREKREVGVQSSERNQD 452
+ER D+ RDR++ SER +D
Sbjct: 192 RERQRETDRKRDRQR------ESERERD 213
Score = 75.5 bits (184), Expect = 1e-13
Identities = 42/199 (21%), Positives = 89/199 (44%), Gaps = 4/199 (2%)
Query: 274 ETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYT 333
ET + + R + R ++E RH + + R + D+ ++++ +
Sbjct: 15 ETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGER 74
Query: 334 DRDYRKERDSHRHREASH-RDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQ 392
R+ ++RD R E ++ RH + D+ R + + +RV RE++++K RE+
Sbjct: 75 QRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRER 134
Query: 393 ERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQD 452
+ DR+ + + + E+E + K E +ER ++ R RE +E + + +
Sbjct: 135 QTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKE---RERHTDME 191
Query: 453 RKESSPNSRAKDKFLDQER 471
R+ R +D+ + ER
Sbjct: 192 RERQRETDRKRDRQRESER 210
Score = 70.1 bits (170), Expect = 5e-12
Identities = 55/197 (27%), Positives = 87/197 (44%), Gaps = 16/197 (8%)
Query: 360 EQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEE 419
E E R R++R +DR R K+ K R ERDRQ+ D+ R E+ E+ K +
Sbjct: 13 ETETMDRQRERRRETDRERDRAKE-SKTEDRHSERDRQR-DRERNRERDRDREREKQTDR 70
Query: 420 HMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMA 479
+ ++ER + D+ R+ E+ + ER DR + R K K + ER
Sbjct: 71 EGERQRERERDRDRQRETERE----RDKERETDRHTETDRERQKQKEREMER-------V 119
Query: 480 KDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRY 539
+D+ER ++K E R T+ +E+ E+ER K R+ E R+R
Sbjct: 120 RDREREKQKEMGRERQ---TDRETDRERERQAERERETGRERKTEDRHRERERERKRERE 176
Query: 540 LARQMARVNAKTYIEKE 556
R+ T +E+E
Sbjct: 177 RKRETKERERHTDMERE 193
Score = 40.0 bits (92), Expect = 0.006
Identities = 46/258 (17%), Positives = 94/258 (36%), Gaps = 59/258 (22%)
Query: 112 EIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEAC 171
E +++E+R E +R+R E D +++ +ER + ERE
Sbjct: 15 ETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE--------- 65
Query: 172 LDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEK 231
KQ D G + ++ R ++R Q +
Sbjct: 66 ----KQTDREG---------------------------ERQRER-------ERDRDRQRE 87
Query: 232 CILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRS 291
+ D + E + ++D + + + E+E R R ++ E + R
Sbjct: 88 TERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQ 147
Query: 292 PSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASH 351
ER T+ R E++ ++ ++++++++E H TD + ++R++ R
Sbjct: 148 AERERETGRERKTEDRHRERERERKRERERKRETKERERH-TDMERERQRETDR------ 200
Query: 352 RDSHWKRHEQEDKPRARD 369
KR Q + R RD
Sbjct: 201 -----KRDRQRESERERD 213
Score = 34.3 bits (77), Expect = 0.31
Identities = 33/148 (22%), Positives = 67/148 (45%), Gaps = 15/148 (10%)
Query: 32 DSDDDDETSVSESLQREAAK-KQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENN 90
D + + +T QRE + + ++T+ E K D + E QK+KE
Sbjct: 61 DREREKQTDREGERQRERERDRDRQRETERERDKERETD----RHTETDRERQKQKEREM 116
Query: 91 PKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKK 150
++ +DR+ + + + R+ ++E E++ Q ERE E G +E +++
Sbjct: 117 ERV---RDREREKQKEMGRE---RQTDRETDRERERQAERERETG----RERKTEDRHRE 166
Query: 151 KLQERAEEEEREKRAAALEACLDVTKQK 178
+ +ER E ER++ E D+ +++
Sbjct: 167 RERERKRERERKRETKERERHTDMERER 194
Score = 32.0 bits (71), Expect = 1.5
Identities = 24/131 (18%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Query: 32 DSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNP 91
D + + + +R+ K++ M++ + ++ E + D D ++++ E
Sbjct: 93 DKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERER 152
Query: 92 KLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKK 151
+ G++RK + H R++E+E++ E++ +RE + + D + +K+
Sbjct: 153 ET--GRERKTEDRH--------RERERERKRERERKRETKERERHTDMERERQRETDRKR 202
Query: 152 LQERAEEEERE 162
++R E ER+
Sbjct: 203 DRQRESERERD 213
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 79.7 bits (195), Expect = 6e-15
Identities = 91/423 (21%), Positives = 173/423 (40%), Gaps = 50/423 (11%)
Query: 129 EREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLL 188
+R E + DD+E + +++++ E R+++ L + ++K + +
Sbjct: 402 DRGSESSDTDDEEL------RHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
Query: 189 NQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKC-ILQTDVKVEENPDAD 247
N+ + +E+ S EAR + V+ K R P E +L+ + +E
Sbjct: 456 NEFIHKEQ-NSLSLLEAREAD--------GDVVNEKKRTPNETTSVLEPKKEHKEKEKQG 506
Query: 248 SDFDAKSSADDEIEETRVNCRREKVIETPENDFK-HHRSQNHSRSPSEERGHS-TRHHTK 305
SS+ +R + V + + R+ + S SP ++ HS +R T
Sbjct: 507 RSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI 566
Query: 306 GSRTSRGHE-----KREDQHQQKQSRDQEN---HYTDRDYRKERDSHRHREASHRDSHWK 357
+R SR K E + + RD+ + +R+ R+ R R R S S +
Sbjct: 567 KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDR 626
Query: 358 RHEQEDKPRARDQRERSDRVWK------REKDREKYSQREQER------DRQQNDQNRPS 405
R + + R+RD+R+ D+ + K K +R++ER DR++ D+ R
Sbjct: 627 RTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERER 686
Query: 406 EKGEKEEKSKAKEEHMKVR------KERYENNDKYRDREKREVGVQSSERNQDRKESSPN 459
E+ +++EK K +E+ K K + E+ + V + + QD K+S+
Sbjct: 687 EQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTK 746
Query: 460 SRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEA 519
K D + + KE+ +KP +S S R E+ Q GK+ R ++
Sbjct: 747 DSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRS------RSVEKSQRSGKKASRKHKS 800
Query: 520 VSK 522
S+
Sbjct: 801 KSR 803
Score = 73.6 bits (179), Expect = 5e-13
Identities = 111/569 (19%), Positives = 226/569 (39%), Gaps = 88/569 (15%)
Query: 43 ESLQREAAKK---QAMKQTKLEI---QKALAEDA-----------TVYEYDSIYDEMQKK 85
E ++RE KK + M+Q + ++ +K EDA + ++ D ++ +
Sbjct: 241 EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV 300
Query: 86 KEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVT 145
+ ++ K+ P+ H+ + E K+ Q + K + E ++ D+E +
Sbjct: 301 EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLD---VTDEEIY-- 355
Query: 146 SAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFY----------RHLLNQAVGEE 195
Y K R + K+ A A +T L G+ R + +E
Sbjct: 356 --YVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDE 413
Query: 196 EVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQ-EKCILQTDVKVEENPDADSDFDAKS 254
E+ ++ + ++EK + ++ + Q E+ + + + + ++ S +A+
Sbjct: 414 ELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEARE 473
Query: 255 SADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSR--- 311
+ D + E + + P+ + K Q SRS S G S+ + S +S
Sbjct: 474 ADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSS 533
Query: 312 ----------------GHEKREDQHQQKQS------RDQENHYTDR---DYRKERDSHRH 346
KR+ +H + +S R + Y+ R + + R R
Sbjct: 534 SSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRD 593
Query: 347 REASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDRE-KYSQREQERDRQQNDQNRPS 405
R S+R+S + + P +R RS R +DR + R + RDR++ D R +
Sbjct: 594 RRRSNRNSIERERRRNRSPSRERRRSRS-----RSRDRRTNRASRSRSRDRRKIDDQRGN 648
Query: 406 -------EKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSP 458
KGE +E+ + KE + K+R + DK R+RE+ + + +D K SS
Sbjct: 649 LSGNSHKHKGEAKEQERKKERSRSIDKDR-KKKDKEREREQDKRKEKQKREEKDFKFSSQ 707
Query: 459 NSRAKDKFLDQERSNKMRNMA---------KDKERNQEKPSNSESSLGAKHRLTEE--GQ 507
+ R K K + ++ +++ +D +++ K S S + R + E G
Sbjct: 708 DDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGS 767
Query: 508 EKGKEQERPPEAVSKFAKRNNEETVMSAR 536
K K+ ++P + S+ +++ ++R
Sbjct: 768 SKEKKAKKPKHSRSRSVEKSQRSGKKASR 796
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 79.7 bits (195), Expect = 6e-15
Identities = 91/423 (21%), Positives = 173/423 (40%), Gaps = 50/423 (11%)
Query: 129 EREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLL 188
+R E + DD+E + +++++ E R+++ L + ++K + +
Sbjct: 402 DRGSESSDTDDEEL------RHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455
Query: 189 NQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKC-ILQTDVKVEENPDAD 247
N+ + +E+ S EAR + V+ K R P E +L+ + +E
Sbjct: 456 NEFIHKEQ-NSLSLLEAREAD--------GDVVNEKKRTPNETTSVLEPKKEHKEKEKQG 506
Query: 248 SDFDAKSSADDEIEETRVNCRREKVIETPENDFK-HHRSQNHSRSPSEERGHS-TRHHTK 305
SS+ +R + V + + R+ + S SP ++ HS +R T
Sbjct: 507 RSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI 566
Query: 306 GSRTSRGHE-----KREDQHQQKQSRDQEN---HYTDRDYRKERDSHRHREASHRDSHWK 357
+R SR K E + + RD+ + +R+ R+ R R R S S +
Sbjct: 567 KARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDR 626
Query: 358 RHEQEDKPRARDQRERSDRVWK------REKDREKYSQREQER------DRQQNDQNRPS 405
R + + R+RD+R+ D+ + K K +R++ER DR++ D+ R
Sbjct: 627 RTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERER 686
Query: 406 EKGEKEEKSKAKEEHMKVR------KERYENNDKYRDREKREVGVQSSERNQDRKESSPN 459
E+ +++EK K +E+ K K + E+ + V + + QD K+S+
Sbjct: 687 EQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTK 746
Query: 460 SRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEA 519
K D + + KE+ +KP +S S R E+ Q GK+ R ++
Sbjct: 747 DSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRS------RSVEKSQRSGKKASRKHKS 800
Query: 520 VSK 522
S+
Sbjct: 801 KSR 803
Score = 73.6 bits (179), Expect = 5e-13
Identities = 111/569 (19%), Positives = 226/569 (39%), Gaps = 88/569 (15%)
Query: 43 ESLQREAAKK---QAMKQTKLEI---QKALAEDA-----------TVYEYDSIYDEMQKK 85
E ++RE KK + M+Q + ++ +K EDA + ++ D ++ +
Sbjct: 241 EKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENV 300
Query: 86 KEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVT 145
+ ++ K+ P+ H+ + E K+ Q + K + E ++ D+E +
Sbjct: 301 EAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLD---VTDEEIY-- 355
Query: 146 SAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFY----------RHLLNQAVGEE 195
Y K R + K+ A A +T L G+ R + +E
Sbjct: 356 --YVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDE 413
Query: 196 EVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQ-EKCILQTDVKVEENPDADSDFDAKS 254
E+ ++ + ++EK + ++ + Q E+ + + + + ++ S +A+
Sbjct: 414 ELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEARE 473
Query: 255 SADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSR--- 311
+ D + E + + P+ + K Q SRS S G S+ + S +S
Sbjct: 474 ADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSS 533
Query: 312 ----------------GHEKREDQHQQKQS------RDQENHYTDR---DYRKERDSHRH 346
KR+ +H + +S R + Y+ R + + R R
Sbjct: 534 SSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRD 593
Query: 347 REASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDRE-KYSQREQERDRQQNDQNRPS 405
R S+R+S + + P +R RS R +DR + R + RDR++ D R +
Sbjct: 594 RRRSNRNSIERERRRNRSPSRERRRSRS-----RSRDRRTNRASRSRSRDRRKIDDQRGN 648
Query: 406 -------EKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSP 458
KGE +E+ + KE + K+R + DK R+RE+ + + +D K SS
Sbjct: 649 LSGNSHKHKGEAKEQERKKERSRSIDKDR-KKKDKEREREQDKRKEKQKREEKDFKFSSQ 707
Query: 459 NSRAKDKFLDQERSNKMRNMA---------KDKERNQEKPSNSESSLGAKHRLTEE--GQ 507
+ R K K + ++ +++ +D +++ K S S + R + E G
Sbjct: 708 DDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGS 767
Query: 508 EKGKEQERPPEAVSKFAKRNNEETVMSAR 536
K K+ ++P + S+ +++ ++R
Sbjct: 768 SKEKKAKKPKHSRSRSVEKSQRSGKKASR 796
>gi|18375528 UPF3 regulator of nonsense transcripts homolog B
isoform 1 [Homo sapiens]
Length = 483
Score = 79.3 bits (194), Expect = 8e-15
Identities = 111/495 (22%), Positives = 203/495 (41%), Gaps = 63/495 (12%)
Query: 30 GNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAE--DATVYEY----DSIYDEMQ 83
G D D ++ E+L + ++ TK ++Q+ L + +E+ S+Y M
Sbjct: 36 GEDKQDRNKEK-KEALSKVVIRRLPPTLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMY 94
Query: 84 KKKE---ENNPKLLLGKDRKPKYIHNLLKAVE---IRKKEQEKRMEKKIQREREMEKGEF 137
+ +N ++L +DR Y+ K E I + ++ KK ++R+ + G
Sbjct: 95 ARAYINFKNQEDIILFRDRFDGYVFLDNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTI 154
Query: 138 DDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEV 197
DD Y+K L+ A + E K + E L+ + K+ + + ++
Sbjct: 155 DDDPE-----YRKFLESYATDNE--KMTSTPETLLEEIEAKN---------RELIAKKTT 198
Query: 198 PKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSAD 257
P SF + + ++EEK + R +E+ + + + D + K
Sbjct: 199 PLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIE-----KLKKI 253
Query: 258 DEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKRE 317
D I E R+K+ + P+ K HR + + +G EK
Sbjct: 254 DRIPE------RDKLKDEPK--IKVHRFLLQA----------VNQKNLLKKPEKGDEKEL 295
Query: 318 DQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRV 377
D+ ++ + D+EN +R + + ++ +D KR E E RD RER
Sbjct: 296 DKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDES---GRDYREREREY 352
Query: 378 WKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDR 437
E+D+E+ + + RQ+ ++ R E+ EKE+ K KEE MK KE+ DK +
Sbjct: 353 ---ERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMK--KEKDTLRDKGKKA 407
Query: 438 EKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLG 497
E E + SSE+ + ++E R ++K D+ + A+ + R +++S
Sbjct: 408 ESTE-SIGSSEKTEKKEEVVKRDRIRNK--DRPAMQLYQPGARSRNRLCPPDDSTKSGDS 464
Query: 498 AKHRLTEEGQEKGKE 512
A R E G KE
Sbjct: 465 AAERKQESGISHRKE 479
Score = 56.2 bits (134), Expect = 8e-08
Identities = 53/198 (26%), Positives = 83/198 (41%), Gaps = 35/198 (17%)
Query: 380 REKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREK 439
RE+ RE+ +RE ER RQ+ ++ R K ++EEK K K+ + +R DK +D K
Sbjct: 211 REEKREERRRREIERKRQREEERR---KWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPK 267
Query: 440 REV-----------GVQSSERNQDRKESSPNSRA----KDKFLDQERSNKMRNMAK--DK 482
+V + D KE +A K+ D+ S + + K D
Sbjct: 268 IKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDS 327
Query: 483 ERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKR--NNEETVMSARDRYL 540
E EKP E G +R E+ +E ER E + + +R EE ++RY
Sbjct: 328 ELKDEKPKRPEDESGRDYR------EREREYERDQERILRERERLKRQEEERRRQKERY- 380
Query: 541 ARQMARVNAKTYIEKEDD 558
KT+ KE++
Sbjct: 381 ------EKEKTFKRKEEE 392
>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
Length = 484
Score = 78.2 bits (191), Expect = 2e-14
Identities = 64/273 (23%), Positives = 113/273 (41%), Gaps = 28/273 (10%)
Query: 243 NPDADSDFDAKSSADDEIEETRVNCRREK-----VIETPENDFKHHRSQNHSRSPSEERG 297
+P SD +K EIEE R + IE + + K S++ SRS
Sbjct: 207 SPSLKSDTSSK-----EIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTP 261
Query: 298 HSTRHHTKGSRTSR-GHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHW 356
S+RH SR+ R H K + + K R + +H +R R+ R + + R+ D
Sbjct: 262 SSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERG-RRSRSTSKTRDKKKEDKEK 320
Query: 357 KRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKA 416
KR + K + +R RS + RE+ R R ++ P + + K
Sbjct: 321 KRSKTPPKSYSTARRSRS-------------ASRERRRRRSRSGTRSPKKPRSPKRKLSR 367
Query: 417 KEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQ---ERSN 473
+ +KE+ ++ DK R R++RE ++++D+++ DK + Q +
Sbjct: 368 SPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDE 427
Query: 474 KMRNMAKDKERNQEKPSNSESSLGAKHRLTEEG 506
+ + +KE+ +EK S K E+G
Sbjct: 428 EEQGYDSEKEKKEEKKPIETGSPKTKECSVEKG 460
Score = 69.3 bits (168), Expect = 9e-12
Identities = 66/247 (26%), Positives = 104/247 (42%), Gaps = 51/247 (20%)
Query: 258 DEIEETRVNCR---REKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH- 313
D+ EE R + R R + TP + +H RS++ SR S + S R +K R R H
Sbjct: 240 DKKEEKRRHSRSRSRSRRRRTPSSS-RHRRSRSRSRRRSHSKSRS-RRRSKSPRRRRSHS 297
Query: 314 --------------EKREDQHQQKQSRDQENHYT----DRDYRKERDSHRHREASH---- 351
+K+++ ++K+S+ Y+ R +ER R R +
Sbjct: 298 RERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKK 357
Query: 352 ---------RDSHWKRHEQE-----DKPRARDQRERSDRVWKREKDREKYSQREQE---- 393
R +RH++E DK R+RD+RERS K+ KD+EK +R+ E
Sbjct: 358 PRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKD 417
Query: 394 -----RDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSE 448
RD + +Q SEK +KEEK + K ++ E RE + G E
Sbjct: 418 VKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHE 477
Query: 449 RNQDRKE 455
+ D +
Sbjct: 478 EDMDMSD 484
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/174 (19%), Positives = 73/174 (41%), Gaps = 15/174 (8%)
Query: 364 KPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKA---KEEH 420
+P ++++ R R R + R S R R ++ + R K +SK+ + H
Sbjct: 238 EPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRS-RRRSHSKSRSRRRSKSPRRRRSH 296
Query: 421 MKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAK 480
+ R R + K RD++K + + + R ++ P S + + + R ++
Sbjct: 297 SRERGRRSRSTSKTRDKKKED-------KEKKRSKTPPKSYSTARRSRSASRERRRRRSR 349
Query: 481 DKERNQEKPSNSESSLGA----KHRLTEEGQEKGKEQERPPEAVSKFAKRNNEE 530
R+ +KP + + L + E+ ++K KE+ R S K+ +++
Sbjct: 350 SGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKD 403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.123 0.333
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,120,455
Number of Sequences: 37866
Number of extensions: 1142825
Number of successful extensions: 29670
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 615
Number of HSP's successfully gapped in prelim test: 1064
Number of HSP's that attempted gapping in prelim test: 6478
Number of HSP's gapped (non-prelim): 8741
length of query: 558
length of database: 18,247,518
effective HSP length: 107
effective length of query: 451
effective length of database: 14,195,856
effective search space: 6402331056
effective search space used: 6402331056
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.