Search of human proteins with 86990441

Search of human proteins with 86990441

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|86990441 MAP/microtubule affinity-regulating kinase 2
isoform a [Homo sapiens]
         (745 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...  1483   0.0  
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...  1471   0.0  
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...  1332   0.0  
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...  1295   0.0  
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...  1292   0.0  
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   985   0.0  
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   874   0.0  
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   872   0.0  
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   863   0.0  
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   861   0.0  
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   630   e-180
gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor...   464   e-130
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        382   e-106
gi|116256471 SNF1-like kinase [Homo sapiens]                          360   2e-99
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         357   3e-98
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               293   3e-79
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              288   2e-77
gi|156105707 SNF related kinase [Homo sapiens]                        280   5e-75
gi|156105705 SNF related kinase [Homo sapiens]                        280   5e-75
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   267   3e-71
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   266   5e-71
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   257   3e-68
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               256   4e-68
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       255   9e-68
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           253   5e-67
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    249   7e-66
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   225   1e-58
gi|14042947 testis-specific serine kinase 1 [Homo sapiens]            191   2e-48
gi|16418343 testis-specific serine kinase 3 [Homo sapiens]            186   9e-47
gi|194294513 testis-specific serine kinase 2 [Homo sapiens]           183   4e-46

>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score = 1483 bits (3840), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60
           MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60

Query: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120
           LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120

Query: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180
           AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180

Query: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240
           PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240

Query: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300
           STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300

Query: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360
           SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360

Query: 361 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 420
           KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP
Sbjct: 361 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 420

Query: 421 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRAS 480
           ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRAS
Sbjct: 421 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRAS 480

Query: 481 TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN 540
           TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN
Sbjct: 481 TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN 540

Query: 541 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 600
           ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI
Sbjct: 541 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 600

Query: 601 FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 660
           FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS
Sbjct: 601 FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 660

Query: 661 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 720
           SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV
Sbjct: 661 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 720

Query: 721 RFKRISGTSMAFKNIASKIANELKL 745
           RFKRISGTSMAFKNIASKIANELKL
Sbjct: 721 RFKRISGTSMAFKNIASKIANELKL 745


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score = 1471 bits (3808), Expect = 0.0
 Identities = 745/755 (98%), Positives = 745/755 (98%), Gaps = 10/755 (1%)

Query: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60
           MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 34  MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 93

Query: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120
           LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 94  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153

Query: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180
           AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 213

Query: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240
           PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273

Query: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300
           STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333

Query: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360
           SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 334 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 393

Query: 361 KVQRSVSANPKQRRFSDQ-AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 419
           KVQRSVSANPKQRRFSDQ AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV
Sbjct: 394 KVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 453

Query: 420 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA 479
           PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA
Sbjct: 454 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA 513

Query: 480 STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH 539
           STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH
Sbjct: 514 STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH 573

Query: 540 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 599
           NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS
Sbjct: 574 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 633

Query: 600 IFSKFTSKFV---------RRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL 650
           IFSKFTSKFV         RRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL
Sbjct: 634 IFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSL 693

Query: 651 RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC 710
           RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC
Sbjct: 694 RFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVC 753

Query: 711 KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
           KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Sbjct: 754 KLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score = 1332 bits (3446), Expect = 0.0
 Identities = 685/745 (91%), Positives = 685/745 (91%), Gaps = 54/745 (7%)

Query: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60
           MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 34  MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 93

Query: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120
           LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 94  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153

Query: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180
           AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 213

Query: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240
           PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273

Query: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300
           STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333

Query: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360
           SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 334 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 393

Query: 361 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 420
           KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP
Sbjct: 394 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 453

Query: 421 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRAS 480
           ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS T P  R  
Sbjct: 454 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS-TAP-QRVP 511

Query: 481 TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN 540
            AS SA                                                    HN
Sbjct: 512 VASPSA----------------------------------------------------HN 519

Query: 541 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 600
           ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI
Sbjct: 520 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 579

Query: 601 FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 660
           FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS
Sbjct: 580 FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 639

Query: 661 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 720
           SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV
Sbjct: 640 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 699

Query: 721 RFKRISGTSMAFKNIASKIANELKL 745
           RFKRISGTSMAFKNIASKIANELKL
Sbjct: 700 RFKRISGTSMAFKNIASKIANELKL 724


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score = 1295 bits (3352), Expect = 0.0
 Identities = 673/746 (90%), Positives = 676/746 (90%), Gaps = 61/746 (8%)

Query: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60
           MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 34  MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 93

Query: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120
           LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 94  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153

Query: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180
           AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 213

Query: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240
           PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273

Query: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300
           STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333

Query: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360
           SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 334 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 393

Query: 361 KVQRSVSANPKQRRFSDQ-AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 419
           KVQRSVSANPKQRRFSDQ AGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV
Sbjct: 394 KVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKV 453

Query: 420 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRA 479
           PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS T P  R 
Sbjct: 454 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS-TAP-QRV 511

Query: 480 STASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAH 539
             AS SA                                                    H
Sbjct: 512 PVASPSA----------------------------------------------------H 519

Query: 540 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 599
           NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS
Sbjct: 520 NISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGS 579

Query: 600 IFSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 659
           IFSKFTSKFVRRNL+   ++      RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT
Sbjct: 580 IFSKFTSKFVRRNLSFRFAR------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 633

Query: 660 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 719
           SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG
Sbjct: 634 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 693

Query: 720 VRFKRISGTSMAFKNIASKIANELKL 745
           VRFKRISGTSMAFKNIASKIANELKL
Sbjct: 694 VRFKRISGTSMAFKNIASKIANELKL 719


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score = 1292 bits (3344), Expect = 0.0
 Identities = 670/745 (89%), Positives = 670/745 (89%), Gaps = 69/745 (9%)

Query: 1   MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 60
           MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS
Sbjct: 34  MIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS 93

Query: 61  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 120
           LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR
Sbjct: 94  LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 153

Query: 121 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 180
           AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP
Sbjct: 154 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSP 213

Query: 181 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 240
           PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
Sbjct: 214 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 273

Query: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300
           STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333

Query: 301 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 360
           SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH
Sbjct: 334 SMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSH 393

Query: 361 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 420
           KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP
Sbjct: 394 KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 453

Query: 421 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRAS 480
           ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS T P  R  
Sbjct: 454 ASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS-TAP-QRVP 511

Query: 481 TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN 540
            AS SA                                                    HN
Sbjct: 512 VASPSA----------------------------------------------------HN 519

Query: 541 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 600
           ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI
Sbjct: 520 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSI 579

Query: 601 FSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 660
           FSKFTSKFVR               RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS
Sbjct: 580 FSKFTSKFVR---------------RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTS 624

Query: 661 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 720
           SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV
Sbjct: 625 SMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGV 684

Query: 721 RFKRISGTSMAFKNIASKIANELKL 745
           RFKRISGTSMAFKNIASKIANELKL
Sbjct: 685 RFKRISGTSMAFKNIASKIANELKL 709


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  985 bits (2546), Expect = 0.0
 Identities = 525/765 (68%), Positives = 610/765 (79%), Gaps = 33/765 (4%)

Query: 3   RGRNSATSA-DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
           R RNS TSA DEQPHIGNYRL KTIGKGNFAKVKLARH+LTG+EVAVKIIDKTQLN +SL
Sbjct: 42  RCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL 101

Query: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA
Sbjct: 102 QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 161

Query: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
           KFRQIVSAVQYCHQK+IVHRDLKAENLLLD DMNIKIADFGFSNEFT GNKLDTFCGSPP
Sbjct: 162 KFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPP 221

Query: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
           YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS
Sbjct: 222 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 281

Query: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301
           TDCENLLKK L+LNP KRG+LEQIMKDRWMNVGHE++ELKPY EP PD+ D +R ++MV+
Sbjct: 282 TDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVT 341

Query: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEG------DTITLKPRPSADLTNSSA 355
           MG+ R+EI D+L+ Q+Y+EVMATY+LLG K  E EG        +  + RPS+DL NS+ 
Sbjct: 342 MGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTL 401

Query: 356 PSPSH-KVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEE-DRESGRKA 413
            SP+H KVQRS+SAN KQRRFSD AGP+IP + SY+K+ Q+N+ E+++ EE D++  RK 
Sbjct: 402 QSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKL 461

Query: 414 SST-----AKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNG 468
            ST     +++ ASPL G ERKK++  PS N+V S  +   RN+ + ER +    ++QNG
Sbjct: 462 GSTTVGSKSEMTASPLVGPERKKSSTIPS-NNVYSGGSMARRNTYVCERTTDRYVALQNG 520

Query: 469 KDSLTMPGSRASTASA----SAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRP 524
           KDS     S +S +SA    ++AV +ARPR HQKSMS S HP K + LP  +   E  RP
Sbjct: 521 KDSSLTEMSVSSISSAGSSVASAVPSARPR-HQKSMSTSGHPIKVT-LPTIKDGSEAYRP 578

Query: 525 STAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPA 584
            T  QRVP ASPSAH+IS++   PDRT FPRG SSRSTFH  QL   R+++++ Y   PA
Sbjct: 579 GTT-QRVPAASPSAHSISTA--TPDRTRFPRGSSSRSTFHGEQL---RERRSVAYNGPPA 632

Query: 585 SPS----GHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKE 640
           SPS      +  RRG S  I SK TSKFVRR+ +E E+  R +T R         +++KE
Sbjct: 633 SPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRS--TSGEPKERDKE 690

Query: 641 EFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHE 700
           E +++KPRSLRFTWSMKTTSSM+PN+MMREIRKVLDAN+C  E  E+++L C+HG    +
Sbjct: 691 EGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQD 750

Query: 701 DFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
             VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 751 SLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  874 bits (2257), Expect = 0.0
 Identities = 484/758 (63%), Positives = 557/758 (73%), Gaps = 66/758 (8%)

Query: 3   RGRNS-ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
           R RNS A+ ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SL
Sbjct: 38  RCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 97

Query: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+
Sbjct: 98  QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARS 157

Query: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
           KFRQIVSAVQYCHQK IVHRDLKAENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPP
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217

Query: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
           YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277

Query: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301
           TDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DELKP+VEP  D  D +R ++MV 
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVG 337

Query: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTIT-------LKPRPSADLTNSS 354
           MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+    +        K RPS+DL NS+
Sbjct: 338 MGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNST 397

Query: 355 APSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 414
             SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K++Q++ A++   +ED  S RK+S
Sbjct: 398 GQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSS 456

Query: 415 STAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLT 473
            +A       P                          SP+L  AS   +A I   K S T
Sbjct: 457 GSAVGGKGIAPA-------------------------SPMLGNASNPNKADIPERKKSST 491

Query: 474 MPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPV 533
           +P S  +        S    R++    S     ++ S +   + N  +P      QR PV
Sbjct: 492 VPSSNTA--------SGGMTRRNTYVCSERTTADRHSVIQNGKENSTIP-----DQRTPV 538

Query: 534 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 589
           AS   H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 539 AS--THSISSAA-TPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591

Query: 590 --SQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKP 647
             SQ R   S ++FSK TSK  RR   E E   R E    +V     + ++K+E +EAKP
Sbjct: 592 PLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNV-----SAEQKDENKEAKP 646

Query: 648 RSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEM 707
           RSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEM
Sbjct: 647 RSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEM 706

Query: 708 EVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
           EVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 707 EVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 744


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  872 bits (2252), Expect = 0.0
 Identities = 485/767 (63%), Positives = 560/767 (73%), Gaps = 75/767 (9%)

Query: 3   RGRNS-ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
           R RNS A+ ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SL
Sbjct: 38  RCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 97

Query: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+
Sbjct: 98  QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARS 157

Query: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
           KFRQIVSAVQYCHQK IVHRDLKAENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPP
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217

Query: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
           YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277

Query: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301
           TDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DELKP+VEP  D  D +R ++MV 
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVG 337

Query: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTIT-------LKPRPSADLTNSS 354
           MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+    +        K RPS+DL NS+
Sbjct: 338 MGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNST 397

Query: 355 APSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 414
             SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K++Q++ A++   +ED  S RK+S
Sbjct: 398 GQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSS 456

Query: 415 STAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLT 473
            +A       P                          SP+L  AS   +A I   K S T
Sbjct: 457 GSAVGGKGIAPA-------------------------SPMLGNASNPNKADIPERKKSST 491

Query: 474 MPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPV 533
           +P S  +        S    R++    S     ++ S +   + N  +P      QR PV
Sbjct: 492 VPSSNTA--------SGGMTRRNTYVCSERTTADRHSVIQNGKENSTIP-----DQRTPV 538

Query: 534 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 589
           AS   H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 539 AS--THSISSAA-TPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591

Query: 590 --SQGRRGASGSIFSKFTSKFVRRNLN---------EPESKDRVETLRPHVVGSGGNDKE 638
             SQ R   S ++FSK TSK  RRN++         E E   R E    +V     + ++
Sbjct: 592 PLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNV-----SAEQ 646

Query: 639 KEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPG 698
           K+E +EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG   
Sbjct: 647 KDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGH 706

Query: 699 HEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
            E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 707 AENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  863 bits (2231), Expect = 0.0
 Identities = 480/759 (63%), Positives = 553/759 (72%), Gaps = 83/759 (10%)

Query: 3   RGRNS-ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
           R RNS A+ ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SL
Sbjct: 38  RCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 97

Query: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+
Sbjct: 98  QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARS 157

Query: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
           KFRQIVSAVQYCHQK IVHRDLKAENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPP
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217

Query: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
           YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277

Query: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301
           TDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DELKP+VEP  D  D +R ++MV 
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVG 337

Query: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTIT-------LKPRPSADLTNSS 354
           MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+    +        K RPS+DL NS+
Sbjct: 338 MGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNST 397

Query: 355 APSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 414
             SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K++Q++ A++   +ED  S RK+S
Sbjct: 398 GQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSS 456

Query: 415 STAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLT 473
            +A       P                          SP+L  AS   +A I   K S T
Sbjct: 457 GSAVGGKGIAPA-------------------------SPMLGNASNPNKADIPERKKSST 491

Query: 474 MPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPV 533
           +P S  +        S    R++    S     ++ S +   + N  +P      QR PV
Sbjct: 492 VPSSNTA--------SGGMTRRNTYVCSERTTADRHSVIQNGKENSTIP-----DQRTPV 538

Query: 534 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 589
           AS   H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 539 AS--THSISSAA-TPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591

Query: 590 --SQGRRGASGSIFSKFTSKFVR-RNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAK 646
             SQ R   S ++FSK TSK  R RN++                      ++K+E +EAK
Sbjct: 592 PLSQTRSRGSTNLFSKLTSKLTRSRNVSA---------------------EQKDENKEAK 630

Query: 647 PRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWE 706
           PRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWE
Sbjct: 631 PRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWE 690

Query: 707 MEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
           MEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 691 MEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 729


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  861 bits (2224), Expect = 0.0
 Identities = 478/752 (63%), Positives = 550/752 (73%), Gaps = 85/752 (11%)

Query: 3   RGRNS-ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
           R RNS A+ ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SL
Sbjct: 38  RCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 97

Query: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+
Sbjct: 98  QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARS 157

Query: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
           KFRQIVSAVQYCHQK IVHRDLKAENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPP
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217

Query: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
           YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277

Query: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301
           TDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DELKP+VEP  D  D +R ++MV 
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVG 337

Query: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHK 361
           MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSE+         RPS+DL NS+  SP HK
Sbjct: 338 MGYSQEEIQESLSKMKYDEITATYLLLGRKSSEV---------RPSSDLNNSTGQSPHHK 388

Query: 362 VQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA 421
           VQRSV ++ KQRR+SD AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A    
Sbjct: 389 VQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGK 447

Query: 422 SPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASL-GQASIQNGKDSLTMPGSRAS 480
              P                          SP+L  AS   +A I   K S T+P S  +
Sbjct: 448 GIAPA-------------------------SPMLGNASNPNKADIPERKKSSTVPSSNTA 482

Query: 481 TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN 540
                   S    R++    S     ++ S +   + N  +P      QR PVAS   H+
Sbjct: 483 --------SGGMTRRNTYVCSERTTADRHSVIQNGKENSTIP-----DQRTPVAS--THS 527

Query: 541 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRR 594
           ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R 
Sbjct: 528 ISSAA-TPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRS 582

Query: 595 GASGSIFSKFTSKFVR-RNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFT 653
             S ++FSK TSK  R RN++                      ++K+E +EAKPRSLRFT
Sbjct: 583 RGSTNLFSKLTSKLTRSRNVSA---------------------EQKDENKEAKPRSLRFT 621

Query: 654 WSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLP 713
           WSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQWEMEVCKLP
Sbjct: 622 WSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLP 681

Query: 714 RLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
           RLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 682 RLSLNGVRFKRISGTSIAFKNIASKIANELKL 713


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  630 bits (1625), Expect = e-180
 Identities = 371/639 (58%), Positives = 434/639 (67%), Gaps = 67/639 (10%)

Query: 3   RGRNSATSA-DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
           R RNS  S  +EQPH+GNYRLL+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSL
Sbjct: 41  RCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL 100

Query: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
           QKLFREVRIMK LNHPNIVKLFEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARA
Sbjct: 101 QKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARA 160

Query: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
           KFRQIVSAV YCHQK IVHRDLKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPP
Sbjct: 161 KFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPP 220

Query: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
           YAAPELFQGKKYDGPEVD+WSLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMS
Sbjct: 221 YAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMS 280

Query: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301
           TDCE++L++FL+LNP+KR TLEQIMKD+W+N+G+E +ELKPY EP  D+ D +R E+MV 
Sbjct: 281 TDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVG 340

Query: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SS 354
           MGYTREEI++SL  Q+YNEV ATYLLLG K+ E  GD         + R  +D TN  SS
Sbjct: 341 MGYTREEIKESLTSQKYNEVTATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSS 399

Query: 355 APSPSH-KVQRSVSAN-PKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRK 412
           +   SH K QRS S+   +QRR SD  GP+    +     T +  AE K   E+R  GRK
Sbjct: 400 SKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELK---EERLPGRK 456

Query: 413 AS-STAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS 471
           AS STA   +  LP          PS+  V S         P            +  KDS
Sbjct: 457 ASCSTAGSGSRGLP----------PSSPMVSSAHNPNKAEIP------------ERRKDS 494

Query: 472 LTMPGS--RASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQ 529
            + P +   +     +  V   RP   + S+           LP  + N      S+   
Sbjct: 495 TSTPNNLPPSMMTRRNTYVCTERPGAERPSL-----------LPNGKEN------SSGTP 537

Query: 530 RVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV---TPASP 586
           RVP ASPS+H+++   G  +R+   RG + RSTFH GQ+R  R       GV    PASP
Sbjct: 538 RVPPASPSSHSLAPPSG--ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASP 595

Query: 587 S-GHS-----QGRRGASGSIFSKFTSKFVRRNLNEPESK 619
           +  H       GR   + ++F+K TSK  RR   +P  +
Sbjct: 596 TLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKR 634


>gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e
           [Homo sapiens]
          Length = 659

 Score =  464 bits (1193), Expect = e-130
 Identities = 276/540 (51%), Positives = 345/540 (63%), Gaps = 71/540 (13%)

Query: 220 QNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDE 279
           ++LKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DE
Sbjct: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236

Query: 280 LKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDT 339
           LKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+   
Sbjct: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296

Query: 340 IT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKK 392
            +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K+
Sbjct: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356

Query: 393 TQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNS 452
           +Q++ A++   +ED  S RK+S +A       P                          S
Sbjct: 357 SQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPA-------------------------S 390

Query: 453 PLLERASL-GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASG 511
           P+L  AS   +A I   K S T+P S  +        S    R++    S     ++ S 
Sbjct: 391 PMLGNASNPNKADIPERKKSSTVPSSNTA--------SGGMTRRNTYVCSERTTADRHSV 442

Query: 512 LPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQV 571
           +   + N  +P      QR PVAS   H+ISS+   PDR  FPRG +SRSTFH     Q 
Sbjct: 443 IQNGKENSTIP-----DQRTPVAS--THSISSAA-TPDRIRFPRGTASRSTFHG----QP 490

Query: 572 RDQQNLPYGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETL 625
           R+++   Y   PASPS  H     SQ R   S ++FSK TSK  RRN++    K R    
Sbjct: 491 RERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSR---- 546

Query: 626 RPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELH 685
                    + ++K+E +EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  
Sbjct: 547 -------NVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQR 599

Query: 686 EKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
           E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 600 ERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 659



 Score =  259 bits (661), Expect = 8e-69
 Identities = 131/143 (91%), Positives = 138/143 (96%), Gaps = 1/143 (0%)

Query: 3   RGRNS-ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
           R RNS A+ ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SL
Sbjct: 38  RCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 97

Query: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+
Sbjct: 98  QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARS 157

Query: 122 KFRQIVSAVQYCHQKFIVHRDLK 144
           KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 158 KFRQIVSAVQYCHQKRIVHRDLK 180


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  382 bits (980), Expect = e-106
 Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)

Query: 17  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 76
           IG Y + +TIGKGNFA VK A H++T  +VA+KIIDKTQL+  +L+K+FREV+IMK+L H
Sbjct: 5   IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64

Query: 77  PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
           P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 65  PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124

Query: 137 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
            IVHRDLKAENLLLDA++NIKIADFGFSN FT G  L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184

Query: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
           +VD+WSLGV+LY LV G+LPFDG  L+ LR RVL GK+RIPF+MST+CE+L++  L+L+P
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244

Query: 257 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 308
           +KR ++EQI K +WM +G  D      +      K+ R+ +         M  MG  +E+
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304

Query: 309 IQDSLVGQRYNEVMATYLLL 328
              SL    Y+   A Y LL
Sbjct: 305 TLQSLRSDAYDHYSAIYSLL 324


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  360 bits (925), Expect = 2e-99
 Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)

Query: 17  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 76
           +G Y + +T+GKGNFA VKLARH +T  +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 24  VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83

Query: 77  PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
           P+I+KL++V+ET+  LY+V E+A  GE+FDYL ++G + E EAR KF QI+SAV+YCH  
Sbjct: 84  PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143

Query: 137 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
            IVHRDLK ENLLLD +M+IK+ADFGF N +  G  L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203

Query: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
           ++D+WSLGV+LY LV GSLPFDG NL  LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263

Query: 257 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 309
           ++R T+ QI + RWM                  Y   L DY D +   +M ++G  R+  
Sbjct: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322

Query: 310 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 363
            +SL    YN   A Y LL      Y++++        +PRP S+DL+    P      Q
Sbjct: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376

Query: 364 RSVSANP 370
             +S +P
Sbjct: 377 EGLSTDP 383


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  357 bits (915), Expect = 3e-98
 Identities = 200/436 (45%), Positives = 274/436 (62%), Gaps = 22/436 (5%)

Query: 17  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 76
           +G Y +  T+GKGNFA VKL RH +T  EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 17  VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76

Query: 77  PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
           P+I+KL++V+ET+  LYLV EYA  GE+FDYL  HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77  PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136

Query: 137 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
            IVHRDLKAENLLLD +MNIKIADFGF N F  G  L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196

Query: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
           ++D+WS+GV+LY LV G+LPFDG  L  LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256

Query: 257 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 309
           SKR T+ QI + +WM +  E    +P + P     +P   E       LM S+G  +++ 
Sbjct: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314

Query: 310 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 361
            +SL  + YN   A Y LL      ++SS   E   D    +P   A+ T + A +    
Sbjct: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLP 374

Query: 362 VQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA 421
           V      +P  R       P      ++S       AE    EE+     K +     P 
Sbjct: 375 V---TMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPV 431

Query: 422 SPLPGLERKKTTPTPS 437
            P+  L RK     PS
Sbjct: 432 PPV--LVRKGCQSLPS 445


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  293 bits (751), Expect = 3e-79
 Identities = 181/455 (39%), Positives = 257/455 (56%), Gaps = 31/455 (6%)

Query: 16  HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 75
           ++G YRL KT+GKG    VKL  H +TG++VA+KI+++ +L+ S L K+ RE+ I+K++ 
Sbjct: 30  YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89

Query: 76  HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 135
           HP+++KL +V E +K LYLV+E+ SGGE+FDYLV  GR+  KEAR  FRQIVSA+ +CH 
Sbjct: 90  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149

Query: 136 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
             I HRDLK ENLLLD   NI+IADFG ++     + L+T CGSP YA PE+ +G+KYDG
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209

Query: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255
              D+WS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+  + + 
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269

Query: 256 PSKRGTLEQIMKDRWMNVG-HEDDELKPYVEPLPDYK------------DPRRTELMVSM 302
           P KR +LEQI K  W   G HE D   P +EP P  +            DP   E M S+
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELDPDVLESMASL 326

Query: 303 G--YTREEIQDSLVGQRYN-EVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSP- 358
           G    RE +   L  +  N E M  YLLL  K      +   L PR   D       SP 
Sbjct: 327 GCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPM 386

Query: 359 --SHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-- 414
              H  +R    + +    +D  G   P     + +  + +++  R      +G  +S  
Sbjct: 387 LSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALE-MAQHSQRSRSVSGASTGLSSSPL 445

Query: 415 STAKVPA---SPLPGL---ERKKTTPTPSTNSVLS 443
           S+ + P    SP PG     R   +PT  T ++ S
Sbjct: 446 SSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  288 bits (736), Expect = 2e-77
 Identities = 170/446 (38%), Positives = 247/446 (55%), Gaps = 21/446 (4%)

Query: 11  ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 70
           A    ++G YRL KT+GKG    VKL  H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 10  AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69

Query: 71  MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 130
           +K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV  GR+  KEAR  FRQI+SA+
Sbjct: 70  LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129

Query: 131 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 190
            +CH   I HRDLK ENLLLD   NI+IADFG ++     + L+T CGSP YA PE+ +G
Sbjct: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189

Query: 191 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 250
           +KYDG + DVWS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+ 
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249

Query: 251 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 302
            + ++ ++R TLE I K  W   G  + E       K  +  LP  +  DP   + M S+
Sbjct: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309

Query: 303 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 359
           G  R+    +QD L  +   E M  +LLL  K      +   L PR   D       SP 
Sbjct: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368

Query: 360 HKVQRSVSANPKQRRFS----DQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 415
             + R     P+++          G  +P   +      + + +  R      SG   S 
Sbjct: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424

Query: 416 TAKVPASPLPGLERKKTTPTPSTNSV 441
            +    +P P   R    PTP    V
Sbjct: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  280 bits (715), Expect = 5e-75
 Identities = 201/608 (33%), Positives = 299/608 (49%), Gaps = 74/608 (12%)

Query: 18  GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 77
           G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 78  NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 136
           NIV+L+EVI+T+  LYL++E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 137 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ + L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 256 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 308
           P +R +LE+I    W+  G +      Y  PL  YK+    E       +++     R+ 
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312

Query: 309 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 345
           I ++L   RYN + ATY LL  +      E E  T +  P                    
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372

Query: 346 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ---------AGPAIPTSNSYSK 391
                 +  L++++ P    +   SV    + +   D          AGPA+ T    S 
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432

Query: 392 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT--PTPSTNSVLST 444
           K  ++  +      +  EED E  +  S + +V     P +  + T+    P  N +   
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492

Query: 445 STNRSRNS------PLLER-----ASLGQASIQNGKDSLTMPGSRASTASASAAVSAARP 493
             +           P L R     AS G    +  +      GS  S++  S   S +R 
Sbjct: 493 GESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRR 552

Query: 494 RQHQKS-MSASVHPNKASGLPPTE--SNCEVPRPSTAPQRVPVASPSAHNI------SSS 544
           R  + S  + S H   +S  PP          +PS A   V  ASPS +N       S S
Sbjct: 553 RLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGS 612

Query: 545 GGAPDRTN 552
           GG P  T+
Sbjct: 613 GGNPTNTS 620


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  280 bits (715), Expect = 5e-75
 Identities = 201/608 (33%), Positives = 299/608 (49%), Gaps = 74/608 (12%)

Query: 18  GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 77
           G Y L KT+G+G+FA VKLARH+ TG++VAVK+IDKT+L++ +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 78  NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCHQK 136
           NIV+L+EVI+T+  LYL++E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 137 FIVHRDLKAENLL-LDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ + L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 256 PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREE 308
           P +R +LE+I    W+  G +      Y  PL  YK+    E       +++     R+ 
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312

Query: 309 IQDSLVGQRYNEVMATYLLLGYK----SSELEGDTITLKPR------------------- 345
           I ++L   RYN + ATY LL  +      E E  T +  P                    
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372

Query: 346 -----PSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ---------AGPAIPTSNSYSK 391
                 +  L++++ P    +   SV    + +   D          AGPA+ T    S 
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432

Query: 392 KTQSNNAE-----NKRPEEDRESGRKASSTAKVPASPLPGLERKKTT--PTPSTNSVLST 444
           K  ++  +      +  EED E  +  S + +V     P +  + T+    P  N +   
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492

Query: 445 STNRSRNS------PLLER-----ASLGQASIQNGKDSLTMPGSRASTASASAAVSAARP 493
             +           P L R     AS G    +  +      GS  S++  S   S +R 
Sbjct: 493 GESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRR 552

Query: 494 RQHQKS-MSASVHPNKASGLPPTE--SNCEVPRPSTAPQRVPVASPSAHNI------SSS 544
           R  + S  + S H   +S  PP          +PS A   V  ASPS +N       S S
Sbjct: 553 RLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGS 612

Query: 545 GGAPDRTN 552
           GG P  T+
Sbjct: 613 GGNPTNTS 620


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  267 bits (682), Expect = 3e-71
 Identities = 153/389 (39%), Positives = 228/389 (58%), Gaps = 23/389 (5%)

Query: 10  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 63
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71

Query: 64  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 123
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131

Query: 124 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 183
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191

Query: 184 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 243
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251

Query: 244 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 297
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306

Query: 298 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 352
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366

Query: 353 SSAPSPSHKVQRSVSANPKQRRFSDQAGP 381
            + P P  +V   V+  P+ R   D+  P
Sbjct: 367 LTRPHP-ERVPFLVAETPRARHTLDELNP 394


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  266 bits (680), Expect = 5e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 11  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 64
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61

Query: 65  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 124
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121

Query: 125 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 184
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181

Query: 185 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 244
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241

Query: 245 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 298
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296

Query: 299 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 328
                 T  E+ +SL  G   +++   Y L+
Sbjct: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  257 bits (656), Expect = 3e-68
 Identities = 153/404 (37%), Positives = 228/404 (56%), Gaps = 38/404 (9%)

Query: 10  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 63
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71

Query: 64  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 113
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR          
Sbjct: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131

Query: 114 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 168
                + EKE+R  F+QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  +
Sbjct: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191

Query: 169 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 228
            G  L T CGSP YAAPE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L ++
Sbjct: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251

Query: 229 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 287
           +  G +  P Y++    +LLK  L ++P KR T++ I +  W        +L  Y+ P  
Sbjct: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306

Query: 288 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 340
           P Y      D    E+      + EE+   L  + + + +A   +L++  +    E    
Sbjct: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366

Query: 341 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGP 381
            L   P     D  + + P P  +V   V+  P+ R   D+  P
Sbjct: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDELNP 409


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  256 bits (655), Expect = 4e-68
 Identities = 192/605 (31%), Positives = 286/605 (47%), Gaps = 90/605 (14%)

Query: 20  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 78
           Y L +T+GKG + KVK A    +G+ VA+K I K ++ +   +  + RE+ IM  LNHP+
Sbjct: 55  YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114

Query: 79  IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 138
           I+ ++EV E +  + ++MEYAS GE++DY+    R+ E+E R  FRQIVSAV YCH+  +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174

Query: 139 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 198
           VHRDLK EN+LLD + NIKIADFG SN +     L TFCGSP YA+PE+  G+ Y GPEV
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234

Query: 199 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 258
           D W+LGV+LYTLV G++PFDG + K L  ++  G+YR P   S D   L++  L++NP +
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293

Query: 259 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 318
           R T+E I    W+N G++        + L D + P                         
Sbjct: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326

Query: 319 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 375
             ++A  +   ++S+ L+ DT        A +   + P+ S  +   QRS+  + K+  F
Sbjct: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377

Query: 376 SDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------- 418
           +     A+P S S     +      KR   +  S          G    ST K       
Sbjct: 378 AQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCR 437

Query: 419 ----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASLG 461
               +P+SP   +PG    K + T     +L           +S  RS +S LL+   + 
Sbjct: 438 TGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVM 497

Query: 462 QASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSA-SVHPNKASGLPPTESNCE 520
            +SI +       P   A   S S +       +H    SA ++ P   S   PT  +  
Sbjct: 498 GSSIPS-----PSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLS 552

Query: 521 VP--------RPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVR 572
            P        R  + P  V ++  S  +  S      + N P     RS   A    Q++
Sbjct: 553 EPGVPAEGLSRSYSRPSSV-ISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQ 611

Query: 573 DQQNL 577
           D + L
Sbjct: 612 DFEGL 616


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  255 bits (652), Expect = 9e-68
 Identities = 128/298 (42%), Positives = 196/298 (65%), Gaps = 8/298 (2%)

Query: 17  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 76
           IG YR+   IG GNF++VKL  H LT ++VA+KI+DKT+L+  + + L RE+  M+ L+H
Sbjct: 71  IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130

Query: 77  PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
           PNI++L+EV+ET   L+LVMEYA GGE+F  +   G++ E E++  F QIVSAV++ H+ 
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190

Query: 137 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
            I+HRDLKAEN+   ++  +K+ DFGFS     G  L+TFCGSPPYAAPELF+ + Y G 
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250

Query: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
            VD+W+LGV+LY +V+G++PF  + + +L++ +L G Y +P ++S  C  L++  L   P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310

Query: 257 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYK-DPRRTELMVSMGYTREEIQDSL 313
           ++R  ++ IM D WM       +  PY  PL  ++ DP+      ++     E++ +L
Sbjct: 311 TERYGIDCIMNDEWM-------QGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTL 361


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  253 bits (646), Expect = 5e-67
 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%)

Query: 20  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 78
           Y  L+T+GKG + KVK AR   +G+ VA+K I K ++ +   L  + RE+ IM  LNHP+
Sbjct: 53  YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111

Query: 79  IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 138
           I+ + EV E    + +VMEYAS G+++DY+    ++ E+EAR  FRQIVSAV YCHQ  +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171

Query: 139 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 198
           VHRDLK EN+LLDA+ NIKIADFG SN +  G  L TFCGSP YA+PE+  GK Y GPEV
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231

Query: 199 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 258
           D WSLGV+LY LV G++PFDG + K L +++  G YR P   S  C  L++  L++NP++
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290

Query: 259 RGTLEQIMKDRWMNVGH 275
           R TLE +    W+N G+
Sbjct: 291 RATLEDVASHWWVNWGY 307


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  249 bits (636), Expect = 7e-66
 Identities = 161/437 (36%), Positives = 235/437 (53%), Gaps = 34/437 (7%)

Query: 20  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 79
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69

Query: 80  VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 139
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129

Query: 140 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 196
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188

Query: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248

Query: 257 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 316
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308

Query: 317 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQ----RSVSANPKQ 372
           +Y+ + ATYLLL  K +   G  + L+    +    S+ P    K        V+A+ K 
Sbjct: 309 QYDHLTATYLLLLAKKA--RGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKN 366

Query: 373 R----------RFSDQAGPAIPTSNSYSKK-TQSNNAENKRPEEDRESGRKASSTAKVPA 421
                            G A P ++ ++K  T+SN  E+K            S T  +  
Sbjct: 367 YVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESK------------SLTPALCR 414

Query: 422 SPLPGLERKKTTPTPST 438
           +P   L+ K+   TP +
Sbjct: 415 TPANKLKNKENVYTPKS 431



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 28/109 (25%), Positives = 57/109 (52%), Gaps = 2/109 (1%)

Query: 637 KEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGT 696
           K K   R+  PR L+  +++ TT  + P++++ EI  +L        + + Y L C   +
Sbjct: 545 KRKGSARDG-PRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQS 602

Query: 697 PGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745
              +  +Q+E+EVC+L +  + G+R +R+ G +  +K +   I +  K+
Sbjct: 603 DFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  225 bits (573), Expect = 1e-58
 Identities = 178/622 (28%), Positives = 290/622 (46%), Gaps = 93/622 (14%)

Query: 12  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 66
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110

Query: 67  EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 126
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170

Query: 127 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 183
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230

Query: 184 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 240
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289

Query: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 296
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349

Query: 297 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYK-------SSELEGDTITLKPRPSAD 349
            +   +GY   ++ ++++  R   ++A Y LL  K        S+++ D++  K R    
Sbjct: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQ-DSLCYKTR-LYQ 407

Query: 350 LTNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENK 401
           +    AP  S++             +   K+ +  ++ G  +     +SKK   N   +K
Sbjct: 408 IEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHK 465

Query: 402 RPE--------------EDRESGRK-----------------------ASSTAKVPASPL 424
           +P               +DR++ +                        ASS+ +    P 
Sbjct: 466 QPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPP 525

Query: 425 PGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQA----------SIQNGKDSLTM 474
           P   R    P P      ST      +  +L+     ++          S  +    L  
Sbjct: 526 PRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNS 585

Query: 475 PGSRASTASASAAVSAARPRQHQKSMSASVHPNKAS------GLPPTESN--CEVPRPST 526
           P S A   S+   +S   P      +   +HP   S        PP E    C  P PS 
Sbjct: 586 PVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSN 645

Query: 527 APQRVPVASPSAHNISSSGGAP 548
            P + P+ SP+   + S G  P
Sbjct: 646 GPMQ-PLGSPNC--VKSRGRFP 664


>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
          Length = 367

 Score =  191 bits (485), Expect = 2e-48
 Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)

Query: 20  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 78
           Y L   +G+G++AKVK A        VA+KIID+ +  +  L+K   RE+ I+ +LNH +
Sbjct: 12  YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71

Query: 79  IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 137
           I+K +E+ ET    +Y+VME A  G++ + +   G + E EAR KF Q+  A++YCH   
Sbjct: 72  IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131

Query: 138 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 192
           +VHRDLK +NLLLD D NIK++DF FS      +        TFCGSP YAAPE+ QG  
Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191

Query: 193 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 248
           Y     D+WSLGVILY +V GS+P+D  N+K++    ++ ++R+ F    +++ +C++L+
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249

Query: 249 KKFLILNPSKRGTLEQIMKDRWM 271
              L  + ++R  +++I+   WM
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWM 272


>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
          Length = 268

 Score =  186 bits (471), Expect = 9e-47
 Identities = 101/257 (39%), Positives = 163/257 (63%), Gaps = 6/257 (2%)

Query: 20  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 78
           Y+L KTIG+G ++KVK A      ++VA+K+IDK       +Q+   RE++I++ L+H N
Sbjct: 10  YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69

Query: 79  IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 137
           I++++E++E+ +  + LVME A GG+VFD ++  G + E  A+A FRQ+V A++YCH   
Sbjct: 70  IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129

Query: 138 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK--LDTFCGSPPYAAPELFQGKKYDG 195
           + HRDLK EN LL    N+K+ DFGF+      ++    TFCGS  YAAPE+ QG  +D 
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188

Query: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 254
            + DVWS+GV+LY ++  SLPFD  ++ ++  +  +G  +     +S DC++LLK+ L  
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248

Query: 255 NPSKRGTLEQIMKDRWM 271
           +   R ++E++    W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265


>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
          Length = 358

 Score =  183 bits (465), Expect = 4e-46
 Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)

Query: 26  IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 84
           +GKG++AKVK A        VAVKIID+ +  +  +++   RE+ I+  +NH +I+K +E
Sbjct: 18  LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77

Query: 85  VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 143
           + ET +  +Y++ME    G++ +++   G + E  AR  FRQ+ SAV+YCH   IVHRDL
Sbjct: 78  IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137

Query: 144 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 198
           K ENLLLD D NIK++DFGFS      +        TFCGS  YAAPE+ Q   Y     
Sbjct: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197

Query: 199 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 254
           D+WSLGVILY +V GS+P+D  +++++    ++ ++R+ F     ++ +C++L+ + L  
Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255

Query: 255 NPSKRGTLEQIMKDRWM 271
           + S+R  +++I+   W+
Sbjct: 256 DVSQRLHIDEILSHSWL 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,362,644
Number of Sequences: 37866
Number of extensions: 1435900
Number of successful extensions: 9274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 771
Number of HSP's successfully gapped in prelim test: 577
Number of HSP's that attempted gapping in prelim test: 5590
Number of HSP's gapped (non-prelim): 2338
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.