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Search of human proteins with 84043963
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
(1220 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 2388 0.0
gi|148746195 trichohyalin [Homo sapiens] 139 1e-32
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 138 4e-32
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 133 1e-30
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 129 2e-29
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 129 2e-29
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 127 5e-29
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 127 5e-29
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 127 6e-29
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 125 2e-28
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 124 4e-28
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 124 4e-28
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 121 5e-27
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 120 8e-27
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 120 8e-27
gi|221219020 NYD-SP11 protein [Homo sapiens] 113 1e-24
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 110 8e-24
gi|104526627 triadin [Homo sapiens] 110 8e-24
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 108 3e-23
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 108 3e-23
gi|53729339 mitochondrial translational initiation factor 2 prec... 107 5e-23
gi|53729337 mitochondrial translational initiation factor 2 prec... 107 5e-23
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 106 2e-22
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 106 2e-22
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 105 3e-22
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 105 3e-22
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 104 6e-22
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 104 6e-22
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 103 1e-21
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 102 2e-21
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 2388 bits (6188), Expect = 0.0
Identities = 1220/1220 (100%), Positives = 1220/1220 (100%)
Query: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK
Sbjct: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
Query: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD
Sbjct: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
Query: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI 180
SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI 180
Query: 181 NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER
Sbjct: 181 NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300
KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300
Query: 301 TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360
TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR
Sbjct: 301 TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360
Query: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE 420
EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE 420
Query: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV 480
ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV
Sbjct: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV 480
Query: 481 PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE 540
PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE
Sbjct: 481 PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE 540
Query: 541 EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT 600
EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT
Sbjct: 541 EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT 600
Query: 601 KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGE 660
KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGE
Sbjct: 601 KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGE 660
Query: 661 AGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLC 720
AGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLC
Sbjct: 661 AGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLC 720
Query: 721 DIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQK 780
DIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQK
Sbjct: 721 DIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQK 780
Query: 781 KNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVE 840
KNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVE
Sbjct: 781 KNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVE 840
Query: 841 LTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ 900
LTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
Sbjct: 841 LTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ 900
Query: 901 IRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLK 960
IRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLK
Sbjct: 901 IRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLK 960
Query: 961 DELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMK 1020
DELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMK
Sbjct: 961 DELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMK 1020
Query: 1021 ASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQK 1080
ASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQK
Sbjct: 1021 ASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQK 1080
Query: 1081 QEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTS 1140
QEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTS
Sbjct: 1081 QEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTS 1140
Query: 1141 IEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD 1200
IEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD
Sbjct: 1141 IEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD 1200
Query: 1201 EMQKSDWQLIVELKKVFEII 1220
EMQKSDWQLIVELKKVFEII
Sbjct: 1201 EMQKSDWQLIVELKKVFEII 1220
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 139 bits (351), Expect = 1e-32
Identities = 139/639 (21%), Positives = 297/639 (46%), Gaps = 59/639 (9%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
+E+E ++ + K+++E++ + + + ++ LE+ Q +K + E ++
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE-----EERRQQLLK 635
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
S++++++ Q+ ++ + + L+ ++ + + + K E + + + ++A+
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Query: 153 KAQKSNKKWDGSEEDEDNSKKIKERSRINSS-GESGDESDEFLQSRKGQKKNQKNKPGPN 211
+ + KW E E ++++ K SR G+ + E + R+ + + + +
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755
Query: 212 IESGNEDDDASFKIKTVAQKKAEK------------KERERKKRDEEKAKL--RKLKEKE 257
+ E+ F + A++K+E+ ++RER+ R EE+ + R L E+E
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEE 815
Query: 258 ELETGKKDQ-SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK 316
E E ++ + ++KE Q EEE ++ + +++ E ++D E + ++
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRR--------ERAQQLQEEEDGLQEDQERRRSQE 867
Query: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAK----LKEEEERQKREEEERIKRLEEL 372
++ +K + +E+ K++ + A+QE L K L+EEEE +REE E+ +R +E
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK-RRRQEQ 926
Query: 373 EAKRKEEERLEQE-----KRERKKQKEKERKERLKKEGKLLTKSQR------EARARAEA 421
E + +EEE+L+QE + ER+K++ +ER+ + +K+ KL K ++ E R R E
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986
Query: 422 TLKL-----LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVM 476
K LQ + ++ ++ ++R +E + RKK Q E +++ ++
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Query: 477 EQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEE 536
E+ E+EE E E+ E + E EE + E ++ E E +E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 537 EEEEEEEDEESEEEEE---EEGESEGSEGDE----EDEKVSDEKDSGKTLDKKPSKEMSS 589
E + EE+E +EEE+ EE E + E E+E+V E++ + L ++P K
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE--QLLREEPEKRRRQ 1164
Query: 590 DSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
+ E ++ ++ + EKRR E + E+
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Score = 125 bits (314), Expect = 2e-28
Identities = 131/635 (20%), Positives = 303/635 (47%), Gaps = 58/635 (9%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVA----VKPTENNE 88
+EQE + ++G+++ EK+++ ++ D + EEL + Q + E A ++ + +E
Sbjct: 142 QEQERELAEGEEQSEKQER-LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHE 200
Query: 89 -EEFTSKDK---------KKKGQKGKKQSF---DDNDSEELEDKDSKSKKTAKPKVEMYS 135
EEF +++ ++KG++ K+Q D +E E+K+ + ++T K E
Sbjct: 201 TEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260
Query: 136 GSDDDDDFNKLPKKAKG--KAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEF 193
++ +L ++ + K ++ + + EE++ + +E+ E E E
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 194 LQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAE---KKERERKKRDEEKAKL 250
+ ++ +++ Q+ + + E+ + +++ E ++E+E ++R+++ +
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 251 RKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNE 310
++L+ +++L +++Q ++E Q + E++ + + + ++ + +
Sbjct: 381 QQLRREQQL---RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 311 GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR----EEEERI 366
++++++++ K+ ++E ++ K++ ++ + ++ K +EEER++R EEEER
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER- 496
Query: 367 KRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLL 426
E + +R+++ R EQE+R ++ K +E +ERL++ + + +RE R E LK
Sbjct: 497 ---REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 427 QAQGVEVPSKDS-LPKKRPIYED---KKRKKIPQQLESKEVSESMELCAAVEVMEQGVPE 482
+ + +E ++ L +++ D K+ ++ QQ +E E +E E +E+ E
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 483 --KEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE 540
+E+ EPEEE + + EE E+ ++ E +E E+ + EEE
Sbjct: 614 ERREQRLKREEPEEERR---------QQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664
Query: 541 EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD--- 597
EE E+ + E EE E +EE E+ + S + P + +SE D+
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKS-----RIPKWQWQLESEADARQSKV 719
Query: 598 -DRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRA 631
R +++ + + + EKRR S+ E+ RA
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Score = 124 bits (312), Expect = 4e-28
Identities = 120/632 (18%), Positives = 297/632 (46%), Gaps = 51/632 (8%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
K ++ ++ + K+++++++D+ + + E E Q +K D+E + EEE
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
+ ++++ Q+ +++ ++ + L+ ++ + + + + E + ++ +L K+ +
Sbjct: 497 REQQERREQQLRREQ-EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 153 KAQKSNK-----KWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207
K + + K + E + K+ +ER + E + ++ L+ + ++ Q+ +
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 208 PGPNIESGNEDDDASFKI-KTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETG-KKD 265
++ +++ ++ K+ Q++ +++ R++++ + +L++ +E+E LE K++
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK 325
+++ Q EEE +++ + + + K + +E D K +K++G++
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRI-----PKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 326 EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR------EEEERIKR----------- 368
+E+E+K+ ++ ++ +E A +++EE Q+R + EE+ +R
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 369 LEELEAKRKEEERLEQEKR-----ERKKQKEKERKERLKKEGKLLTKSQREARARAEATL 423
E+ E + + EER ++E+R E K+Q+ ++R+ER K+ L + Q + R RA+
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ--- 847
Query: 424 KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK 483
Q Q E ++ ++R E ++ +K QLE + L A + EQ E+
Sbjct: 848 ---QLQEEEDGLQEDQERRRS-QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 484 EETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEE---- 539
+ E + E+ E + E +EE + E ++ E +E +E E +
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 540 ---EEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSD 596
+++E++ EE E+ E + E+E++ E++ +++ + + +Y
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 597 DDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
D+ +EE + +R EKRRL+ + E+
Sbjct: 1024 DELQQEEEQLLREER--EKRRLQERERQYREE 1053
Score = 117 bits (294), Expect = 5e-26
Identities = 115/654 (17%), Positives = 298/654 (45%), Gaps = 70/654 (10%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKAD---RETVAVKPTENNEE 89
+E+EPQ+ + +++E++ + + ++ +E +E + Q ++ + R + E EE
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 90 EFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKK 149
++++++ ++ ++Q E E + + ++ + + ++ +++ +L ++
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 150 AKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL----QSRKGQKKNQK 205
+ + ++ ++ ++ ++ + R E ++ L + + ++K+++
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 206 NKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLR---KLKEKEELETG 262
+ ++ E+ K + ++ +++ +++ KRD+E+ + KL+E+E E
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 263 KK---------DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
++ ++ +++ +R+ EEE ++ ++ + + EE+ E E++ ++
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 314 KKKDKKKKKGEKEEKE------------KEKKKGPSKATVKAMQEALAKLKEEEERQKR- 360
++++++ K+ ++E ++ + K++ + + +E + +L++EE R++R
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 361 ----EEEERIKRL---EELEAKRKEEERLEQEKRERKKQKEKERKERL-----------K 402
EEER ++L EE E +R+++ R EQ++R ++ K +E +ERL +
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 403 KEGKLLTKSQREARARAEATLKLLQAQ-GVEVPSKDSLPKKRPIYEDKKRKKIPQQLESK 461
+E +L + Q +AR R ++ + Q Q E ++ S RP ++ +R++ Q+ E K
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR--QEQEEK 738
Query: 462 EVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEE-TEKVEG 520
EL +EE + +EEE D W+A E +++
Sbjct: 739 RRRRESEL-----------QWQEEERAHRQQQEEEQRRDFTWQ-WQAEEKSERGRQRLSA 786
Query: 521 NKVHIEVKENPEEEEEEEEEEE----EDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSG 576
E +E EE ++ E+ E+EE E+ + E E E+E+ ++
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846
Query: 577 KTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
+ L ++ S + R ++ + + R +R ++K E+LR
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Score = 115 bits (289), Expect = 2e-25
Identities = 124/651 (19%), Positives = 301/651 (46%), Gaps = 104/651 (15%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
+E+ Q+ + ++++E+++Q + L+ ++L E Q RE + + E+
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ---LRREQQLRREQQLRREQQL 413
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
++++ + ++ ++ ++ E+ +++ + ++ + + E +++ ++ +
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE----TERHEQ 469
Query: 153 KAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNI 212
+ +K K D EE + K++E R E + ++ L+ + +++ Q+ +
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEER----REQQERREQQLRREQEERREQR------L 519
Query: 213 ESGNEDDDASFKIKTVAQKKAEKKERERK--KRDEEKAKLRKLKEKEELETGKKDQSKQK 270
+ E++ ++++ Q + E++ER + KR+EEK +L+++ + K++Q +++
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK----RLEQERREQRLKREQEERR 575
Query: 271 ESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
+ K EEE + ++ + EE+ E E+ +++++ +++ K E+ E+E+
Sbjct: 576 DQLLKREEERRQQRLKRE------QEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629
Query: 331 EKKKGPSKATVKAMQEALAKLKEE--EERQKREEEERIKRLEELEAKRKEEERLEQEKRE 388
++ S+ + Q+ L + ++E E+R KREEEE +RLE+ + EEER EQE E
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE--ERLEQRLKREHEEERREQELAE 687
Query: 389 RKKQKEKER-KERL-----------------------KKEGKLLTKSQREARARAEATLK 424
++++ +ER K R+ K+EG+ + Q E R R E+ L+
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES--MELCAAVEVMEQG--- 479
+ + R E+++R+ Q +++E SE L A + EQ
Sbjct: 748 WQEEERAH----------RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797
Query: 480 --VPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE 537
E+++ PEEEE + + ++E + +E + ++ +E ++ +EE
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRR----QRREREKELQFLEEEE-QLQRRERAQQLQEE 852
Query: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEK----------------------VSDEKDS 575
E+ +ED+E +E+ + + EE+ K + +E++
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Query: 576 GKTLDKKPSKEMSSDSEYDSDDDRTKEERAY---DKAKRRIEKRRLEHSKN 623
+ +++ + + +Y ++ +EE ++ KRR ++R ++ K+
Sbjct: 913 LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Score = 115 bits (287), Expect = 3e-25
Identities = 103/512 (20%), Positives = 246/512 (48%), Gaps = 49/512 (9%)
Query: 149 KAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKP 208
+A G ++ + DG E + ++ +++ R + D L+ GQ++ QK +
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRF-------EPRDRQLEEEPGQRRRQKRQE 143
Query: 209 GPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ-- 266
+ E+ ++K+ ++R+R++RDEE + R+ ++ E +++Q
Sbjct: 144 QERELAEGEEQ---------SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 267 -SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG-- 323
K E++ +EE ++ + ++ EEK + +D ++++K+ +K++
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRR-KGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE----RIKRLEELEAKRKEE 379
KEE++ ++++ + ++ +E L KL+ +E R++R+EEE R++R ++L K++EE
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 380 ERLEQEKR----ERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPS 435
R +QE+R ER++Q+E+ R+++L++E + + Q E + L+ + E
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 436 KDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVM-------EQGVPEKEETPP 488
+ L +++ + +++ ++ Q +++ +L ++ EQ + ++E
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 489 PVEPEEEE------DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEE 542
+ E+E E DW + +EETE+ E + K+ + ++EEE E
Sbjct: 434 HEQKHEQERREQRLKREQEERRDW--LKREEETERHEQERR----KQQLKRDQEEERRER 487
Query: 543 EDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602
+ EEE E+ E + E E+ +++ + +++ + + S+ + + + +E
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 603 ERAYDKAKRRIEKRRLEHSKNVNTEKLRAPII 634
+ + ++R+E+ R E E+ R ++
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Score = 112 bits (281), Expect = 2e-24
Identities = 116/565 (20%), Positives = 259/565 (45%), Gaps = 74/565 (13%)
Query: 92 TSKDKKKKGQ-KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150
T D++K+ + GK+ D EE D + + ++E G ++
Sbjct: 93 TGLDEEKRARCDGKESLLQDRRQEE----DQRRFEPRDRQLEEEPG-----------QRR 137
Query: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210
+ K Q+ ++ EE + +++++R R E + E+ + + + + ++ +
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK 270
E+ D+ + + + + + +K RE K++ + + R +E+EE E K++ +K
Sbjct: 198 GHETEEFPDEEQLRRRELLELR--RKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRK 255
Query: 271 ESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
E ++ EEE + + + E +K ++++ + E++E+E+
Sbjct: 256 EEEKLQEEEPQRQREL--------------------QEEEEQLRKLERQELRRERQEEEQ 295
Query: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQ------ 384
++++ + ++ QE + ++EE R+++E E+ + E + +R++EER EQ
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Query: 385 --EKRE---RKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSL 439
E+RE R++Q+E+ R+++L++E +L +RE + R E L+ Q ++ + L
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQL----RREQQLRREQQLRREQ----QLRREQQL 407
Query: 440 PKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTE 499
+++ + +++ ++ QQL ++ E E E EQ + ++E EEE
Sbjct: 408 RREQQLRREQQLRR-EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466
Query: 500 DAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE--------EEEEEEEEDEESEEEE 551
+ + D+E E+ E + +E +E E++E E+EE E+ + +EEE
Sbjct: 467 HEQERRKQQLKRDQEEERRE-RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 552 EE-----EGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD--RTKEER 604
E E + EE + +++ K L+++ ++ + + D + +EER
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585
Query: 605 AYDKAKRRIEKRRLEHSKNVNTEKL 629
+ KR E+R + K E+L
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERL 610
Score = 110 bits (274), Expect = 1e-23
Identities = 111/624 (17%), Positives = 288/624 (46%), Gaps = 71/624 (11%)
Query: 34 EQEPQKSKGKKKKEKKKQDFD-----EDDILKELEELSLEAQGIKADRETVAVKPTENN- 87
++E Q + ++++++++Q+ D E+ +L+E EE L Q ++ E
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374
Query: 88 -----EEEFTSKDKKKKGQKGKKQSFDDNDSEEL-EDKDSKSKKTAKPKVEMYSGSDDDD 141
E+ +++++K K ++Q ++L +D+D K ++ + + S + D
Sbjct: 1375 KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE----EEQQLSRQERDR 1430
Query: 142 DFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQK 201
F + ++ + + Q+ +K+ E+ + K R E ++ LQ R+ Q+
Sbjct: 1431 KFRE--EEQQVRRQERERKFLEEEQQLRQERHRKFR-----------EEEQLLQEREEQQ 1477
Query: 202 KNQKNKPGPNIESGNE----DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRK-LKEK 256
+++ + +E + + D F+ + + ++ E+K E +++ + + RK L+E+
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 257 EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK 316
++L ++ Q ++++ RKF EE E ++ + ++++
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREE--------------------EQLRQEREEQQLSRQER 1577
Query: 317 DKK-KKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAK 375
D+K + + +K ++++++K QE +L++E +R+ RE+E+ ++ EE +
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Query: 376 RKEEER--LEQE----KRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQ 429
R+E +R LE+E ++ER++Q +R + ++E +LL + + + R E K + +
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 430 GV---EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEET 486
+ + L +++ + + +K ++ + ++ +E +L E + + E++
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL-RRQERYRKILEEEQLR 1756
Query: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEE 546
P E + D + E + + E +++ + + +E EE+ +E EE++
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE--EEQLRQEREEQQLRP 1814
Query: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAY 606
+ + + E E + +E+++++ E+D + ++ ++ + ++ +E
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQRLRQERDR----QYRAEEQFATQEKSRREEQELWQEEEQ 1870
Query: 607 DKAKRRIEKRRLEHSKNVNTEKLR 630
+ + R K R EH + E+ R
Sbjct: 1871 KRRQERERKLREEHIRRQQKEEQR 1894
Score = 108 bits (270), Expect = 3e-23
Identities = 120/625 (19%), Positives = 280/625 (44%), Gaps = 61/625 (9%)
Query: 55 EDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSE 114
E++ ++LE+ L + + D + + + E + E+ ++++ Q+ + ++ E
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ-----ERRRWQQRDRHFPEEEQLE 1300
Query: 115 ELEDKDSK--SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSK 172
E K++K +K+ + K + ++ + +K + + Q ++ + ++ +
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Query: 173 KIKERS-RINSSGESGDESDEFLQ----SRKGQKKNQKNKPGPNIESGNEDDDASFKIKT 227
K +E R G E ++ L+ RK K+ Q+ + + +D D F+ +
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE- 1419
Query: 228 VAQKKAEKKERERKKRDEEKA--------------------KLRKLKEKEELETGKKDQS 267
+++ ++ER+RK R+EE+ + RK +E+E+L +++Q
Sbjct: 1420 --EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 268 -KQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE 326
++E RKF EE + + E +++ P + E ++ +++K ++E
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 327 EKEKEKKKGPSKATV---KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEER-- 381
++ + +++G + K +E + + EE++ R+E +R RLEE + +R+E+ER
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 382 LEQE----KRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKD 437
+E E ++E ++Q +ER + +++ +LL + + + R E K L+ E P
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE----EEPQLR 1653
Query: 438 SLPKKRPIYEDKKRKKIPQQLESKEVSESM----ELCAAVEVMEQGVPEKEETPPPVEPE 493
+++ + D+ RK ++ +E E E EQ + +E ++ E
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 494 EEEDTEDAGLDDWEAMASDEETEKVE------GNKVHIEVKENPEEEEEEEEEEEEDEES 547
++ ++ E +ETE+ + K+ E + PE EE++ +E D +
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 548 EEEEE--EEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERA 605
EEE+ +E E + E D K +E+ + +++ + D +Y ++++ + E
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Query: 606 YDKAKRRIEKRRLEHSKNVNTEKLR 630
+ ++ +++ + EK R
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSR 1858
Score = 105 bits (263), Expect = 2e-22
Identities = 115/603 (19%), Positives = 277/603 (45%), Gaps = 45/603 (7%)
Query: 44 KKKEKKKQDFDEDDILKELEELSLEAQGIKA---DRETVAVKPTENNEEEFTSKDKKKKG 100
+++E+ ++ F+ D ++LEE + + K +RE + +E +D++++
Sbjct: 113 RRQEEDQRRFEPRD--RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD 170
Query: 101 QKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKK 160
++ +Q + + EE ++ + + + E + + L + KG+ +K ++
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 161 WDGSEE--DEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIE---SG 215
+ + E+ K+ ++R + E + +E + R+ Q++ ++ + E
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 216 NEDDDASFKIKTVAQ--KKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQ 273
E++ +++ Q +K E++ RE+++ E+ + R+ +E+ + +++Q +++E Q
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350
Query: 274 RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE----KEEKE 329
+ E+E + + + EE+ E E +++ + +++ + E +E++
Sbjct: 351 LRREQEEERREQQLRR---EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 330 KEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR----KEEERLEQE 385
+ +++ + ++ Q+ + +EE QK E+E R +RL+ + +R K EE E+
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467
Query: 386 KRERKKQKEKERKERLKKEG--KLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443
++ER+KQ+ K +E ++E KL + +RE + R E L+ Q + E K ++R
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 444 PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
++R + QQL +E E E E ++ E+ E E EE D
Sbjct: 528 L----QQRLRSEQQLR-REQEERREQLLKREEEKRLEQERREQRLKREQEERRD------ 576
Query: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESE----EEEEEEGESEG 559
+ + +EE + + E E + EE E E+E+ + EE EEE +
Sbjct: 577 ---QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633
Query: 560 SEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLE 619
+ +E++E+ ++ + ++ + + + E + + R K E ++ ++ + + E
Sbjct: 634 LKSEEQEER--RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 620 HSK 622
++
Sbjct: 692 QAR 694
Score = 101 bits (251), Expect = 5e-21
Identities = 126/686 (18%), Positives = 309/686 (45%), Gaps = 98/686 (14%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
K+++ + E + D L ++ G +EP+K ++++E++K+ +E+++ +E
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLG------EEPEK---RRRQEREKKYREEEELQQEE 1000
Query: 63 EELSLEAQGIKA----DRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELED 118
E+L E + + +R+ + EE+ ++++K+ + +++ + + EEL+
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY--REEEELQQ 1058
Query: 119 KDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERS 178
++ E G + + + ++ K ++ ++ + +E ++ +ER
Sbjct: 1059 EE-----------EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 179 R-INSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
R E E ++ L+ + +++ Q+ + E+++ + + + +++ EK+
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELE-----RQYREEEEVQQEEEQLLREEPEKRR 1162
Query: 238 R---ERKKRDEEKAKL------------------RKLKEKEELETGKKDQSKQKESQR-- 274
R ER+ R+EE+ + R+ +E+EEL+ K+ Q + E QR
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Query: 275 -KFEEETVKSKVTVDTGVIPASEEKAE---------TPTAAEDDNE---GDKKKKDKKKK 321
K++ E K D V E + ++ D + G+++++D++++
Sbjct: 1223 LKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE 1282
Query: 322 KG----------EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEE 371
+ E+E+ E+E++K + K+ +E +E EE+++R+E +R R EE
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342
Query: 372 LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV 431
+ +EE+ L +++R+RK ++E+ R + ++G+ + ++ R + L + Q +
Sbjct: 1343 QLLQEREEQPLRRQERDRKFREEELRHQ---EQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVE 491
++ ++ D+K ++ QQL +E EQ V +E +E
Sbjct: 1400 RCQEREQQLRQD---RDRKFREEEQQLSRQERDRKF------REEEQQVRRQERERKFLE 1450
Query: 492 PEEE--EDTEDAGLDDWEAMASDEETE--KVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547
E++ ++ ++ + + EE + + E ++ +E ++ +E + + E++ S
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 548 EEEEEEEGESEGS-EGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAY 606
+E E + E E + K E+ + ++ + D ++ ++++ ++ER
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF-REEEQLRQEREE 1569
Query: 607 DKAKR--RIEKRRLEHSKNVNTEKLR 630
+ R R K RLE K E+ R
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQER 1595
Score = 93.6 bits (231), Expect = 1e-18
Identities = 101/540 (18%), Positives = 258/540 (47%), Gaps = 38/540 (7%)
Query: 35 QEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENN----EEE 90
+E Q+ + ++++++ +QD D +E ++LS + + K E V+ E EEE
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRK-FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 91 FTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150
+ ++ + + ++Q + + ++L + + +K + + ++ + D F + ++
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLH-RQERDRKFLEEEQQLRR-QERDRKFREQELRS 1510
Query: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210
+ +K ++ + K ++E ++ + + RK +++ Q +
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD--RDRKFREEEQLRQERE 1568
Query: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK 270
+ ++ D F+++ ++K ++E+ERK ++E+ +LR+ + +++L + + ++
Sbjct: 1569 EQQLSRQERDRKFRLE---EQKVRRQEQERKFMEDEQ-QLRRQEGQQQLRQERDRKFRED 1624
Query: 271 ESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
E + EE + D + + + ++ D+K +++++ E EE++
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQE----- 385
+++ K +E +L+ +E +K +EE+ R +ELE K +EEE+L QE
Sbjct: 1685 RRQERDRK-----FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 386 --KRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443
++ER ++ +E + R ++E + L + +R+ + R E L+ + + ++ S++S K R
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ-EREEQQLRSQESDRKFR 1798
Query: 444 P---IYEDKKRKKI-PQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTE 499
+ ++++ +++ PQQ + K E +L ++ EQ ++E EE+ T+
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQL----QLEEQEQRLRQERDRQYRAEEQFATQ 1854
Query: 500 DAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEG 559
+ + + + +EE ++ + E K E +++EE+ + E + +EG+ G
Sbjct: 1855 EKSRREEQELWQEEEQKRRQER----ERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHG 1910
Score = 87.8 bits (216), Expect = 6e-17
Identities = 89/478 (18%), Positives = 228/478 (47%), Gaps = 49/478 (10%)
Query: 35 QEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSK 94
QE + +++++ ++Q+ D +EL E + ++ +++ + + +F +
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL----HRQQRQRKFLQE 1536
Query: 95 DKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKA 154
+++ + Q+ +Q D D + E++ + ++ + + S + D F ++ K +
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQER----EEQQLSRQERDRKFRL--EEQKVRR 1590
Query: 155 QKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDE-FLQSRKGQKKNQKNKPGPNIE 213
Q+ +K+ EDE ++ + + ++ + DE LQ R+ Q+ +++ + +E
Sbjct: 1591 QEQERKF---MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647
Query: 214 SGNE------------DDDASFK-----IKTVAQKKAEKKERERKKRDEEKAKLRKLKEK 256
+ D D F+ ++ +++ ++ER+RK R+EE+ R+ +E+
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Query: 257 EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK 316
+ L+ ++ Q +++E +RKF EE ++ +T ++ E+ +++++
Sbjct: 1708 KFLQ--EEQQLRRQELERKFREE---EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR 376
++++ +++ +E+E+ + + QE+ K +EEE+ ++ EE++++ + R
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822
Query: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436
EEE+L+ E++E++ ++E++R+ R +++ KS+RE Q E K
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE-----------QELWQEEEQK 1871
Query: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSE--SMELCAAVEVMEQGVPEKEETPPPVEP 492
++R + E+ R++ ++ ++V E S E ++E G + P P
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSP 1929
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 138 bits (347), Expect = 4e-32
Identities = 133/577 (23%), Positives = 269/577 (46%), Gaps = 36/577 (6%)
Query: 73 KADRETVAVKP----TENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS---KK 125
K+++ETV V+ T+ EE ++K+ K ++GK++ + + E ++++KS ++
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 126 TAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGE 185
A P+ E S ++ K P +AK ++ K + E KE ++ +
Sbjct: 509 AASPEKEAKSPVKEEA---KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK 565
Query: 186 SGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE-RERKKRD 244
S ++ + + K+ + P E +A K + K E K E K
Sbjct: 566 SPEKEEA---KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
Query: 245 EEKAKL-RKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303
+E+AK ++K E+ ++ K+++K E + E+E KS + V + +A++P
Sbjct: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV----KAEAKSPE 678
Query: 304 AAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE---ERQKR 360
A+ + + K +K K ++E K EK K P K K+ ++A + +KEE E+ K
Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKS 738
Query: 361 EEEERIKRLEELEA--KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418
+E K E+ ++ K K + E + K++ + ++ ++ K K + ++ +
Sbjct: 739 PVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK 798
Query: 419 AEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEV---SESMELCAAVEV 475
A++ LK + + P K+ +PKK + K ++ PQ+++ KE +E + A +
Sbjct: 799 AKSPLK----EDAKAPEKE-IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT 853
Query: 476 MEQGVPEKEETPPPV--EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEE 533
E+ +KEE P +P+ EE E A E+ ++ E + KV KE P +
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
Query: 534 EE--EEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDS 591
E E+ + +E+ E +++E ++ E S+ E+ E ++KD+ + KKP ++ +++
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEA 973
Query: 592 EYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
+ DD +E + KA++ + + + EK
Sbjct: 974 KAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010
Score = 127 bits (318), Expect = 8e-29
Identities = 132/598 (22%), Positives = 262/598 (43%), Gaps = 49/598 (8%)
Query: 10 EDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEA 69
E S K+ + ++ E + E+E +++K ++ KE++ + +E + +E +
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAE 507
Query: 70 QGIKADRETVA-VKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAK 128
+ ++E + VK + E S +K++ + +S + S E+ S + +
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 129 PKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGD 188
K E S ++ K P+KAK A++ K ++ E +KE ++ + +S
Sbjct: 568 EKEEAKSPAEV-----KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
Query: 189 ESD-----EFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK- 242
+ + E K + ++ P E ++A K + KAE K E+ K
Sbjct: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKS 682
Query: 243 ------RDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE 296
+ EKAK +E + E K ++ +S K + + T + P E
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 297 E-----KAETPTAAED-DNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAK 350
E KA++P A+ D + + K K++ +K EK K P K VK+ ++A +
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802
Query: 351 LKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTK 410
LKE+ + ++E I + EE+++ KEEE+ ++ K + +K +E K + +
Sbjct: 803 LKEDAKAPEKE----IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD 858
Query: 411 SQREARARAEATLKLLQAQ---GVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESM 467
S++E + EA ++ + VE P + + K+ EDKK+ P++
Sbjct: 859 SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK---------- 908
Query: 468 ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527
E A VEV E P+++ EP++ + E + + + A +++ K E K
Sbjct: 909 EAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK----- 963
Query: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSK 585
PEE+ + E + +ED+++ +E + ++E +E ++ D K K + K +K
Sbjct: 964 --KPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ-KDSKPPEKATEDKAAK 1018
Score = 108 bits (271), Expect = 2e-23
Identities = 121/496 (24%), Positives = 216/496 (43%), Gaps = 41/496 (8%)
Query: 149 KAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKP 208
K K++K + E+ ++++ E + E G E +E + + + ++ K
Sbjct: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKE-EEGGEEEEAEGGEEETKS 503
Query: 209 GPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSK 268
P E+ + + +A +K A+ AE K E+ EE ++K E+ ++ K+++K
Sbjct: 504 PPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK----EEAKSPAEVKSPEKAKSPAKEEAK 559
Query: 269 QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK 328
+ E+E KS V + S K E + AE + K K++ K E K
Sbjct: 560 SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619
Query: 329 EKEKKKGPSKATVKAMQEALAKLKEEE---ERQKREEEERIKRLEELEAKRKEEERLEQE 385
K++ S A VK+ ++A + KEE E+ K E+E K E+ ++ K E + E
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK-SPE 678
Query: 386 KRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR-- 443
K + + E + E+ K K KS +A++ + K + V + P+K
Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKS 738
Query: 444 PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
P+ E+ K P++ +S E +++++ V+ E P KEE P + E+
Sbjct: 739 PVKEEAKS---PEKAKSPEKAKTLD----VKSPEAKTPAKEEARSPADKFPEKAKSPV-- 789
Query: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD 563
EE + E K +KE+ + E+E ++EE + +EEE+ E +
Sbjct: 790 --------KEEVKSPE--KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKV---- 835
Query: 564 EEDEKVSDEKD---SGKTLDKKPS-KEMSSDSEYDSDDDRTKEERAYDKAKR---RIEKR 616
+E K ++E+ + KT +KK S KE + E K+E A +K K +K
Sbjct: 836 KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895
Query: 617 RLEHSKNVNTEKLRAP 632
E K V T + AP
Sbjct: 896 EAEDKKKVPTPEKEAP 911
Score = 90.9 bits (224), Expect = 7e-18
Identities = 143/652 (21%), Positives = 270/652 (41%), Gaps = 77/652 (11%)
Query: 18 DLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRE 77
++ L +I+G+GAA+ Q + + +D + D+ L E I+A E
Sbjct: 237 EVGELLGQIQGSGAAQAQ----------MQAETRDALKCDVTSALRE-------IRAQLE 279
Query: 78 TVAVKPTENNEEEFTSK-DKKKKGQKGKKQSFDDNDSEELEDK--------DSKSKKTAK 128
AV+ T +EE F + D+ + K + E E + + ++ K+ K
Sbjct: 280 GHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTK 339
Query: 129 PKVEMYSGSDDDDDFNKLPKKAKG----KAQKSNKKWDGSEEDEDNSKKIKERSRINSSG 184
+E +D + + A+ N KW+ + + + + + ++
Sbjct: 340 DSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEI 399
Query: 185 ESGDESDEFLQSRKGQKKNQKNKPG--PNIESGNEDDDASFKIKTVAQKKAEKKERERKK 242
+ + E + R G + P P I S + + K +K+EK+ ++
Sbjct: 400 AAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEE 459
Query: 243 RDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETP 302
+ EE ++ E+EE E K+++ K++E + E E EE+ ++P
Sbjct: 460 QTEETQVTEEVTEEEEKEA-KEEEGKEEEGGEEEEAE--------------GGEEETKSP 504
Query: 303 TAAEDDN-EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE---RQ 358
A E + E + K K++ K E K EK++ S A VK+ ++A + KEE +
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 359 KREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER-KERLKKEGKLLTKSQREARA 417
K E+E K E+++ K + ++E + + K E+ K +K+E K +++ +
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 418 RAEATLKLLQAQGVEVPSKDSL--PKKRPIYEDKKRKKIPQQLES--KEVSESMELCAAV 473
A++ ++ + + P+K+ P+K E K+ K P++ +S K ++S E +
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE-KEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Query: 474 EVMEQGVPEKEETPPPVEPEEEEDT-----EDAGLDDWEAMASDEETEKVEGNKVHI-EV 527
E PEK ++P E + E E+A + EE + E K + E
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743
Query: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKV-SDEKDSGKTLD------ 580
++PE+ + E+ + D +S E + E S D+ EK S K+ K+ +
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL 803
Query: 581 ----KKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
K P KE+ E S KEE + K + ++ E K T K
Sbjct: 804 KEDAKAPEKEIPKKEEVKSP---VKEEEKPQEVKVKEPPKKAEEEKAPATPK 852
Score = 82.4 bits (202), Expect = 2e-15
Identities = 94/384 (24%), Positives = 176/384 (45%), Gaps = 36/384 (9%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAE-IEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
+K++ KS + K + +A + E + A+ + P+K+K K+E K + + + +E
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
+ +K + +T K +EE S +K K +K K L+ K
Sbjct: 716 AKSPEKAKSPVKEEAKTPE-KAKSPVKEEAKSPEKAKSPEKAKT----------LDVKSP 764
Query: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQ---KSNKKWDGSEEDEDNSKKIKERS 178
++K AK E S +D + K P K + K+ KS K D +++ KK + +S
Sbjct: 765 EAKTPAKE--EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS 822
Query: 179 RINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKER 238
+ +E + ++ ++ KK ++ K P E D+ K + +K+A K +
Sbjct: 823 PVKE-----EEKPQEVKVKEPPKKAEEEK-APATPKTEEKKDS--KKEEAPKKEAPKPKV 874
Query: 239 ERKKRDE-EKAKLRKLK-EKEELETGKKDQSKQKESQRKFE-EETVKSKVTVDTGVIPAS 295
E KK EK K K++ +KEE E KK + +KE+ K E +E K K +
Sbjct: 875 EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 296 EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE 355
+ KA+ P+ +KK+ +KK ++E+ +K ++K ++A K + L+K E
Sbjct: 935 DAKAKEPS-----KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK---EP 986
Query: 356 ERQKREEEERIKRLEELEAKRKEE 379
+ K E+ E+ ++ ++K E+
Sbjct: 987 SKPKAEKAEKSSSTDQKDSKPPEK 1010
Score = 80.5 bits (197), Expect = 9e-15
Identities = 106/489 (21%), Positives = 203/489 (41%), Gaps = 59/489 (12%)
Query: 192 EFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERE------------ 239
E L+S K + Q+++ +E ++ D AS++ + + Q AE + +
Sbjct: 333 EALKSTKDSLERQRSE----LEDRHQADIASYQ-EAIQQLDAELRNTKWEMAAQLREYQD 387
Query: 240 ----RKKRDEEKAKLRKLKEKEELETGKKD-QSKQKESQRKFEEETVKSKVTVDTGVIPA 294
+ D E A RKL E EE G E K + KV + +
Sbjct: 388 LLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVV 447
Query: 295 SEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKG----------------PSK 338
+ + ET E E ++ ++++ E +E+E ++++G P++
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAE 507
Query: 339 ATVKAMQEALAKLKEE---------EERQKREEEERIKRLEELEAKRKEEERLEQEKRER 389
+EA + +KEE E+++ + +K E+ ++ KEE + E +
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 390 KKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDK 449
+K++ K E +K K + ++ EA++ AEA V+ +K K P+ E+
Sbjct: 568 EKEEAKSPAE-VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA 626
Query: 450 K---RKKIPQQLES--KEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504
K K P++ +S KE ++S E + E E PEK ++P E + E +
Sbjct: 627 KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP--V 684
Query: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDE 564
EA + ++ V+ E ++P +EE + E+ + EE + E + +
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 565 EDEKVSDEKDSGKTLD-KKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKN 623
+ + + + KTLD K P + + E S D+ E+ K+ + E + E +K+
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA---KSPVKEEVKSPEKAKS 801
Query: 624 VNTEKLRAP 632
E +AP
Sbjct: 802 PLKEDAKAP 810
Score = 58.5 bits (140), Expect = 4e-08
Identities = 79/302 (26%), Positives = 122/302 (40%), Gaps = 38/302 (12%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
+K K+ + T D +A E A + ++ P+K+K K+E K + + + ++
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA 807
Query: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
+ E I E + E +E K+ KK ++ K + + E KDSK
Sbjct: 808 KAPEKE---IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE----EKKDSK 860
Query: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
K PK E ++ K P K K K K EE ED K + +
Sbjct: 861 --KEEAPKKEAPKPKVEE---KKEPAVEKPKESKVEAK---KEEAEDKKK-------VPT 905
Query: 183 SGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK 242
+ E + K ++K + K E DDA K K AEKKE +K
Sbjct: 906 PEKEAPAKVEVKEDAKPKEKTEVAK--------KEPDDAKAK---EPSKPAEKKEAAPEK 954
Query: 243 RD--EEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIP---ASEE 297
+D EEKAK + K K E + + D++ KE + E+ KS T P A+E+
Sbjct: 955 KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Query: 298 KA 299
KA
Sbjct: 1015 KA 1016
Score = 57.4 bits (137), Expect = 8e-08
Identities = 62/293 (21%), Positives = 114/293 (38%), Gaps = 45/293 (15%)
Query: 343 AMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLK 402
++ E L K+ K + EE+IK +E+ E + E +E + ++ E+E KE +
Sbjct: 421 SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
Query: 403 KEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKE 462
+EGK + E E K A+ P K++ K P+ E+ K P + +S
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA---KSPVKEEAKS---PAEAKS-- 532
Query: 463 VSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNK 522
PEKEE P E + E + ++ ++
Sbjct: 533 ------------------PEKEEAKSPAEVKSPEKAKSPAKEEAKSPP------------ 562
Query: 523 VHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGES--EGSEGDEEDEKVSDEKDSGKTLD 580
E K +EE + E + E+++ +EE +S E ++ V +E S
Sbjct: 563 ---EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619
Query: 581 KKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPI 633
+E S +E S + + K+ + + E +K + EK ++P+
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK--SPEKAKSPV 670
Score = 32.3 bits (72), Expect = 2.8
Identities = 36/179 (20%), Positives = 76/179 (42%), Gaps = 13/179 (7%)
Query: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL--- 348
+ A E AA + + + ++ +E + + G ++ ++ QE L
Sbjct: 118 LEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLED 177
Query: 349 ---AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKE--KERKERLKK 403
+ + ++E ++REE E R A+ E R++ +K+ + Q+E R+ ++
Sbjct: 178 IAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEE 237
Query: 404 EGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKE 462
G+LL + Q A+A+ +QA+ + D R I + + L+S+E
Sbjct: 238 VGELLGQIQGSGAAQAQ-----MQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEE 291
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 133 bits (334), Expect = 1e-30
Identities = 155/643 (24%), Positives = 282/643 (43%), Gaps = 69/643 (10%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLE-------AQGIKADRETVAVKPTE 85
++Q+ Q++ G+ ++ + D+ D +E+ E+ +QGI + ++
Sbjct: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS 580
Query: 86 NNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNK 145
+ E E ++K+G + K + + E +++ K K K E+ S DD
Sbjct: 581 DEEVEIP---EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILS-----DDLTD 632
Query: 146 LPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQK---K 202
+ ++GKA+ + DG E D + + G SG E + + KG+K +
Sbjct: 633 KAEVSEGKAKSVGEAEDGPEGRGDGTCE---------EGSSGAEHWQDEEREKGEKDKGR 683
Query: 203 NQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETG 262
+ +PG + E ++ KK + +E+E+K+R++ K R +E EE
Sbjct: 684 GEMERPGEGEKELAEKEE---------WKKRDGEEQEQKEREQGHQKERN-QEMEEGGEE 733
Query: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKK 322
+ + +++E R+ EEE G E + E +++ G ++K +++ +
Sbjct: 734 EHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793
Query: 323 GEKEEKEKE----KKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE 378
GE EE+E E +K+ + ++E + +EEEE + EEEE EE E + +E
Sbjct: 794 GEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
Query: 379 EE-RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKD 437
E + E+E E + ++E E E +E + + + E E + +G ++
Sbjct: 854 GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE------EEEGEGEGEEE 907
Query: 438 SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEE- 496
+ + K ++ ++ E + E E E G E EE E EEEE
Sbjct: 908 GEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE-----GEGEDGEGEGEEEEGEWEGEEEEG 962
Query: 497 --DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEE 554
+ E+ G + E + E E+ EG E +E EEE E EEE E + E EEE E E
Sbjct: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022
Query: 555 GESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIE 614
GE EG EG+ E E+ E++ G+ +K+ E ++ + +++ +E + + + E
Sbjct: 1023 GEVEGEEGEGEGEEEEGEEE-GEEREKEGEGE---ENRRNREEEEEEEGKYQETGEEENE 1078
Query: 615 KRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQ 657
++ E K V+ K G V GK K K T+ Q
Sbjct: 1079 RQDGEEYKKVSKIK---------GSVKYGKHKTYQKKSVTNTQ 1112
Score = 98.2 bits (243), Expect = 4e-20
Identities = 154/652 (23%), Positives = 282/652 (43%), Gaps = 106/652 (16%)
Query: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
QK K + T ++ D E + + +E K +GK K+ Q +E
Sbjct: 521 QKQKKQQ-TIGELTQDTALTENDDSDEYEEMSEMK-EGKACKQHVSQGIFMTQPATTIEA 578
Query: 65 LSLEAQGIKADRETVA-VKPTENNEEEFTSKDKKKK---GQKGKKQSFDDNDSEELEDKD 120
S E I ++E K E+E + ++ K G+K K + D+ +++ E +
Sbjct: 579 FSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSE 638
Query: 121 SKSKKTAKPK-----------VEMYSGSDD-DDDFNKLPKKAKGKAQKSN---------- 158
K+K + + E SG++ D+ + +K KG+ +
Sbjct: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAE 698
Query: 159 ----KKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIES 214
KK DG E+++ ++ ++ R E G+E + +G ++ ++ K G E
Sbjct: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEE 758
Query: 215 GNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQR 274
G ++ + + EK+E ERKK EE+A KE++ E G + + +++E++
Sbjct: 759 GEGEE---------VEGEREKEEGERKK--EERAG----KEEKGEEEGDQGEGEEEETEG 803
Query: 275 KFEEETVKSKVT---VDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE-KEEKEK 330
+ EE+ +V V+ G EE+ E E++ EG++++ + ++++GE K E+E
Sbjct: 804 RGEEKEEGGEVEGGEVEEGK-GEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG 862
Query: 331 EKKKGPSKATVKA----MQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE---RLE 383
E+ +G + +E + +EE E + EEE + EE E + +EEE + E
Sbjct: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922
Query: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQR------------EARARAEATLKLLQAQGV 431
+E E + + E+E E ++G+ + + E E + + +G
Sbjct: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982
Query: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESK-EVSESMELCAAVEVMEQGVPEKEETPPPV 490
E + ++ E ++ + ++ E + E E E+ VE E+G E
Sbjct: 983 EEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG-EEGEGE-------- 1033
Query: 491 EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEE 550
EEE+ E+ G EE EK EG E +EN EEEEEEE + +E+ EE
Sbjct: 1034 --GEEEEGEEEG----------EEREK-EG-----EGEENRRNREEEEEEEGKYQETGEE 1075
Query: 551 EEEEGESEGSEGDEEDEKVSDEKDSGK-TLDKKPSKEMSSDSEYDSDDDRTK 601
E E + EE +KVS K S K K K+ ++++ + + R+K
Sbjct: 1076 ENER------QDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSK 1121
Score = 87.4 bits (215), Expect = 7e-17
Identities = 95/470 (20%), Positives = 217/470 (46%), Gaps = 36/470 (7%)
Query: 10 EDSTKDDIDLDALAAEIEGAGA-----AKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
+D ++ + D E+E G A+++E +K G+++++K+++ + + +E+EE
Sbjct: 670 QDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEE 729
Query: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSK 124
E G + E EEE + K++ +G++ + E K+ ++
Sbjct: 730 GGEEEHGEGEEEEG-----DREEEEEKEGEGKEE--GEGEEVEGEREKEEGERKKEERAG 782
Query: 125 KTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSG 184
K K + E G ++++ + +G+ ++ + +G E +E ++ +E
Sbjct: 783 KEEKGEEEGDQGEGEEEE-----TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEE 837
Query: 185 ESGD------ESDEFLQSRKGQKKNQK---NKPGPNIESGNEDDDASFKIKTVAQKKAEK 235
E G+ E +E KG+++ ++ + G E E+++ + + + + E+
Sbjct: 838 EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE 897
Query: 236 KERERKKRDEEKAKLRKLK-EKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPA 294
+E E + +E + + + + E + E G++ + + +E + + E E + + + G
Sbjct: 898 EEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEG 957
Query: 295 SEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE-EKEKEKKKGPSKATVKAMQEALAKLKE 353
EE+ E E + EG++ + + ++++GE E E+E+ +++G + + +E + +E
Sbjct: 958 EEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEG--EGEEEGEGEGEE 1015
Query: 354 EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLL-TKSQ 412
EEE + E E + E E + EEE E+EK ++ + R+E ++EGK T +
Sbjct: 1016 EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEE 1075
Query: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE-----DKKRKKIPQQ 457
R E K+ + +G K +K+ + ++R K+P Q
Sbjct: 1076 ENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQ 1125
Score = 84.7 bits (208), Expect = 5e-16
Identities = 101/466 (21%), Positives = 206/466 (44%), Gaps = 60/466 (12%)
Query: 6 KNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEK---KKQDFDEDDILKEL 62
+ + E+ +++ + + EG G E E +K +G++KKE+ K++ +E+ E
Sbjct: 737 EGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEG 796
Query: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
EE E +G E E E E +++++ ++G+ + ++ + EE E + +
Sbjct: 797 EEEETEGRG----EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEE-EEGEGEEEEGEGEE 851
Query: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
+ K + E G +++ ++ +G+ ++ + +G EE E ++ +
Sbjct: 852 EEGEGKGEEEGEEGEGEEEG-----EEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906
Query: 183 SGESGDESDEFLQSRKGQKKNQKNK-PGPNIESGNEDDDASFKIKTVAQKKAEKKERERK 241
GE E +E KG+++ ++ + G E E +D + E +E E +
Sbjct: 907 EGEGEGEEEE--GEGKGEEEGEEGEGEGEEEEGEGEGEDG----------EGEGEEEEGE 954
Query: 242 KRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAET 301
EE E+ E E ++ + + +E + + EEE + + + G EE+ E
Sbjct: 955 WEGEE--------EEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEG-----EEEGEE 1001
Query: 302 PTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKRE 361
E++ EG+ +++++ + +GE E +E E +G + + +E + + EE R+ RE
Sbjct: 1002 EGEGEEEGEGEGEEEEEGEVEGEVEGEEGE-GEGEEEEGEEEGEEREKEGEGEENRRNRE 1060
Query: 362 EEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421
EE EE E K +E E E+++ ++ K+ + + K GK T ++
Sbjct: 1061 EE------EEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKK-------- 1106
Query: 422 TLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK------IPQQLESK 461
++ Q G E SK + KR + K +P LE K
Sbjct: 1107 SVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWNNVLPHYLELK 1152
Score = 69.7 bits (169), Expect = 2e-11
Identities = 70/345 (20%), Positives = 155/345 (44%), Gaps = 39/345 (11%)
Query: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
G+ ++ K E +++ + E EG G +E E ++ +G+ K E +E
Sbjct: 817 GEVEEGKGEREEEEE---EGEGEEEEGEGEEEEGEGEEEEGEGKGE------------EE 861
Query: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQ-KGKKQSFDDNDSEELEDKD 120
EE E +G + + E + EEE + ++++G+ +G+++ + + EE E K
Sbjct: 862 GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKG 921
Query: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEED-EDNSKKIKERSR 179
+ + + + E G + +D +G+ ++ +W+G EE+ E ++ E
Sbjct: 922 EEEGEEGEGEGEEEEGEGEGED-------GEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG 974
Query: 180 INSSGESGDESDEFL-QSRKGQKKNQKNKPGPNIESGNEDDDASFKI---------KTVA 229
GE +E E + +G+++ ++ G G +++ ++ +
Sbjct: 975 EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEG 1034
Query: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE---TVKSKVT 286
+++ ++E E ++++ E + R+ +E+EE E GK ++ ++E++R+ EE K K +
Sbjct: 1035 EEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGS 1094
Query: 287 VDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKK--KKGEKEEKE 329
V G ++K+ T T + K K+ K G K+
Sbjct: 1095 VKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKK 1139
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 129 bits (323), Expect = 2e-29
Identities = 114/381 (29%), Positives = 182/381 (47%), Gaps = 42/381 (11%)
Query: 218 DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
D+ S+K+KT+ + EKK R+K EEKA++++LK ++ ++ K+D ++ E +
Sbjct: 3 DEKDSWKVKTLDEILQEKK---RRKEQEEKAEIKRLKNSDDRDS-KRDSLEEGELRDHCM 58
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPS 337
E T+++ P E + EDD+ K + +K+ K++++K+
Sbjct: 59 EITIRNS--------PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWK 110
Query: 338 KATVKAMQEALAKLKEEEERQKREEEERIKRLEEL-EAKRKEEERLEQEKRERKKQKEKE 396
A VK + K EE+ + R E ER KR E E R+E +RLEQ ERK+++E++
Sbjct: 111 HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ--LERKRERERK 168
Query: 397 RKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQ 456
+E+ K++ + Q+E RAE K +A+ EV + R Y DK +
Sbjct: 169 MREQQKEQ-----REQKERERRAEERRKEREARR-EVSAHHRT--MREDYSDKVKASHWS 220
Query: 457 QLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETE 516
+ + E EL + P KEE E + D +D + D E S E+
Sbjct: 221 RSPPRPPRERFELGDGRK------PVKEEKME--ERDLLSDLQD--ISDSERKTSSAESS 270
Query: 517 KVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSG 576
E E +E EEEEEE EE EE EEEEEEE E GS +E E+ ++E
Sbjct: 271 SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS-- 328
Query: 577 KTLDKKPSKEMSSDSEYDSDD 597
+EMS D E ++++
Sbjct: 329 -------EEEMSEDEERENEN 342
Score = 61.2 bits (147), Expect = 6e-09
Identities = 75/384 (19%), Positives = 169/384 (44%), Gaps = 59/384 (15%)
Query: 54 DEDDI--LKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDN 111
DE D +K L+E+ E + K E +K +N+++ + +D ++G+ +
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELR-------D 55
Query: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNS 171
E+ ++S ++ + M ++DD P + + +K + + D +++
Sbjct: 56 HCMEITIRNSPYRR----EDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKH 111
Query: 172 KKIKERS--RINSSGESGDES--DEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKT 227
++KER R E D++ + Q R+ + + +E + K++
Sbjct: 112 ARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 171
Query: 228 VAQKKAEKKERERK---KRDEEKAKL---------------------------RKLKEKE 257
+++ E+KERER+ +R E +A+ R +E+
Sbjct: 172 QQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERF 231
Query: 258 ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD 317
EL G+K ++K +R + ++ + A AE+ + +E++ E ++++++
Sbjct: 232 ELGDGRKPVKEEKMEERDLLSD-LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 290
Query: 318 K-----KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE--ERQKREEEERIKRLE 370
+ + ++ E+EE+E+E++ G + + +A +++ ++ EEE E ++RE E + +
Sbjct: 291 EGSTSEESEEEEEEEEEEEEETGSN--SEEASEQSAEEVSEEEMSEDEERENENHLLVVP 348
Query: 371 ELEAKRK--EEERLEQEKRERKKQ 392
E R E E E+E E Q
Sbjct: 349 ESRFDRDSGESEEAEEEVGEGTPQ 372
Score = 42.4 bits (98), Expect = 0.003
Identities = 41/220 (18%), Positives = 101/220 (45%), Gaps = 3/220 (1%)
Query: 42 GKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQ 101
G +K K++ +E D+L +L+++S + + + A + + EEE ++++++G
Sbjct: 234 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 293
Query: 102 KGKK-QSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKK 160
++ + ++ + EE E+ S S++ ++ E S + +D + + +S
Sbjct: 294 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD 353
Query: 161 WDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDD 220
D S E E+ +++ E + +S+ GD + + K + K P ++ ++
Sbjct: 354 RD-SGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEE 412
Query: 221 ASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE 260
+ + + R + K+ +E L++LK ++E E
Sbjct: 413 FQC-LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE 451
Score = 40.0 bits (92), Expect = 0.014
Identities = 28/125 (22%), Positives = 60/125 (48%), Gaps = 13/125 (10%)
Query: 509 MASDEETEKVEGNKVHIEVKENPEEEEEEEE----EEEEDEESEEEEEEEGESEG----- 559
M ++++ KV+ ++ K+ +E+EE+ E + +D +S+ + EEGE
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
Query: 560 ---SEGDEEDEKVSDEKDSGKTLDKKPSKEMS-SDSEYDSDDDRTKEERAYDKAKRRIEK 615
+ ++ + D + +L KP ++MS + + D++ KE+ + + K R +
Sbjct: 61 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHE 120
Query: 616 RRLEH 620
RR H
Sbjct: 121 RRKRH 125
Score = 31.6 bits (70), Expect = 4.8
Identities = 30/149 (20%), Positives = 68/149 (45%), Gaps = 11/149 (7%)
Query: 11 DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ 70
DS + ++ +AE G+G+ +E+E ++ + ++ ++ + +E++ +E EE
Sbjct: 259 DSERKTSSAESSSAE-SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG---- 313
Query: 71 GIKADRETVAVKPTENNEEEFTSKDKKKKGQKG---KKQSFDDNDSEELEDKDSKSKKTA 127
++ E + + E EE S+D++++ + +S D DS E E+ + + +
Sbjct: 314 ---SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 370
Query: 128 KPKVEMYSGSDDDDDFNKLPKKAKGKAQK 156
+ G D LP + K + K
Sbjct: 371 PQSSALTEGDYVPDSPALLPIELKQELPK 399
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 129 bits (323), Expect = 2e-29
Identities = 116/395 (29%), Positives = 181/395 (45%), Gaps = 69/395 (17%)
Query: 218 DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
D+ S+K+KT+ + EKK R+K EEKA++++LK ++ ++ K+D ++ E +
Sbjct: 3 DEKDSWKVKTLDEILQEKK---RRKEQEEKAEIKRLKNSDDRDS-KRDSLEEGELRDHCM 58
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD---KKKKKGEKEEKEKEKKK 334
E T+++ P E + EDD+ K + K+K K+EK KEKK
Sbjct: 59 EITIRNS--------PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKH 110
Query: 335 GPSKATV------KAMQEALAKLKEEEERQKREEEERIK------RLEELEAKRKEEERL 382
K K +E K + E ERQKR E R RLE+LE KR+ E ++
Sbjct: 111 ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 170
Query: 383 EQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKK 442
++++E+++QKE+ER+ +++ +REAR A + +
Sbjct: 171 REQQKEQREQKERERRAEERRK-------EREARREVSAHHRTM---------------- 207
Query: 443 RPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAG 502
R Y DK + + + E EL + P KEE E + D +D
Sbjct: 208 REDYSDKVKASHWSRSPPRPPRERFELGDGRK------PVKEEKME--ERDLLSDLQD-- 257
Query: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG 562
+ D E S E+ E E +E EEEEEE EE EE EEEEEEE E GS
Sbjct: 258 ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 317
Query: 563 DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597
+E E+ ++E +EMS D E ++++
Sbjct: 318 EEASEQSAEEVS---------EEEMSEDEERENEN 343
Score = 77.0 bits (188), Expect = 1e-13
Identities = 85/411 (20%), Positives = 175/411 (42%), Gaps = 47/411 (11%)
Query: 114 EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQ---------KSNKKWDGS 164
E L++K + ++ K +++ SDD D +K +G+ + S + + S
Sbjct: 15 EILQEKKRRKEQEEKAEIKRLKNSDDRD--SKRDSLEEGELRDHCMEITIRNSPYRREDS 72
Query: 165 EED---EDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDA 221
ED ED+S IK +++ + DE + +K + +K + + E+ D
Sbjct: 73 MEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDK 132
Query: 222 SFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV 281
+ + +++ +E R++RD + RK + + ++ +K+Q +QKE +R+ EE
Sbjct: 133 ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRK 192
Query: 282 KSKVTVDTGV------------IPASEEKAETPTAAEDDNE-GDKKKKDKKKKKGEKEEK 328
+ + + + AS P + E GD +K K++K E++
Sbjct: 193 EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLL 252
Query: 329 EKEKKKGPSKATVKAMQEALAKL---KEEEERQKREEEERIKRLEELEAKRKEEERLEQE 385
+ S+ + + + A+ EEEE ++ EEEE EE E + +EEE E+E
Sbjct: 253 SDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE 312
Query: 386 -----------KRERKKQKEKERKERLKKEGKLL----TKSQREARARAEATLKLLQA-- 428
E ++E E + E LL ++ R++ EA ++ +
Sbjct: 313 TGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTP 372
Query: 429 QGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG 479
Q + D +P + + ++++P+ L + + S+E + +E+G
Sbjct: 373 QSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEG 423
Score = 57.8 bits (138), Expect = 6e-08
Identities = 87/413 (21%), Positives = 163/413 (39%), Gaps = 52/413 (12%)
Query: 8 KSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSL 67
+ EDS +D + D A +++++ K +K+KEKK E + E +
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 68 EAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS-EELEDKDSKSKKT 126
E Q KA RE +++K+ + ++ S + D E+LE K + +K
Sbjct: 128 EEQD-KARREW----------------ERQKRREMAREHSRRERDRLEQLERKRERERKM 170
Query: 127 AKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGES 186
+ + E + + + ++ K + + ED S K+K S
Sbjct: 171 REQQKEQREQKERE---RRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRP 227
Query: 187 GDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEE 246
E E RK K +K + + + D+ K + AE ++ +EE
Sbjct: 228 PRERFELGDGRK-PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 286
Query: 247 KAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAE 306
+ +E+EE T ++ + +++E + + EE S+ + SEE+ E
Sbjct: 287 E------EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 340
Query: 307 DDNEGDKKKKDK-KKKKGEKEEKEKEKKKG----------------PSKATVKAMQEALA 349
++N + + + GE EE E+E +G P+ + ++ QE
Sbjct: 341 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK 400
Query: 350 KLKEEEERQKREEEERIKRLEE------LEAKRKEEERLEQEKRERKKQKEKE 396
L + + EE + + R+EE AK K+ + + KR K +KEKE
Sbjct: 401 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKR-LKMEKEKE 452
Score = 45.8 bits (107), Expect = 2e-04
Identities = 45/185 (24%), Positives = 83/185 (44%), Gaps = 18/185 (9%)
Query: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE--ETPPPVEPEEEEDT-EDA 501
+ E K+RK+ ++ E K + S + + + +E+G E P ED+ ED
Sbjct: 17 LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDR 76
Query: 502 GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE----EEEEEEEEDEESEEEEEEEGES 557
G +D +++A + KVH E +E++ +E+E E E + EE+++
Sbjct: 77 GEED-DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARR 135
Query: 558 EGSEGDEED---EKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIE 614
E + E E+D + L++K +E ++ KE+R + +RR E
Sbjct: 136 EWERQKRREMAREHSRRERDRLEQLERKRERERKM-------REQQKEQREQKERERRAE 188
Query: 615 KRRLE 619
+RR E
Sbjct: 189 ERRKE 193
Score = 39.3 bits (90), Expect = 0.023
Identities = 29/126 (23%), Positives = 60/126 (47%), Gaps = 14/126 (11%)
Query: 509 MASDEETEKVEGNKVHIEVKENPEEEEEEEE----EEEEDEESEEEEEEEGESEG----- 559
M ++++ KV+ ++ K+ +E+EE+ E + +D +S+ + EEGE
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
Query: 560 ---SEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE--YDSDDDRTKEERAYDKAKRRIE 614
+ ++ + D + +L KP ++MS + + D+ R +++ A K K R
Sbjct: 61 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120
Query: 615 KRRLEH 620
+RR H
Sbjct: 121 ERRKRH 126
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 127 bits (320), Expect = 5e-29
Identities = 120/391 (30%), Positives = 184/391 (47%), Gaps = 52/391 (13%)
Query: 218 DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
D+ S+K+KT+ + EKK R+K EEKA++++LK ++ ++ K+D ++ E +
Sbjct: 3 DEKDSWKVKTLDEILQEKK---RRKEQEEKAEIKRLKNSDDRDS-KRDSLEEGELRDHCM 58
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD---KKKKKGEKEEKEKEK-- 332
E T+++ P E + EDD+ K + K+K K+EK KEK
Sbjct: 59 EITIRNS--------PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCR 110
Query: 333 -----KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEEL-EAKRKEEERLEQEK 386
+G A VK + K EE+ + R E ER KR E E R+E +RLEQ
Sbjct: 111 HHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ-- 168
Query: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIY 446
ERK+++E++ +E+ K++ + Q+E RAE K +A+ EV + R Y
Sbjct: 169 LERKRERERKMREQQKEQ-----REQKERERRAEERRKEREARR-EVSAHHRT--MREDY 220
Query: 447 EDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDW 506
DK + + + E EL + P KEE E + D +D + D
Sbjct: 221 SDKVKASHWSRSPPRPPRERFELGDGRK------PVKEEKME--ERDLLSDLQD--ISDS 270
Query: 507 EAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEED 566
E S E+ E E +E EEEEEE EE EE EEEEEEE E GS +E
Sbjct: 271 ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEAS 330
Query: 567 EKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597
E+ ++E +EMS D E ++++
Sbjct: 331 EQSAEEVS---------EEEMSEDEERENEN 352
Score = 60.1 bits (144), Expect = 1e-08
Identities = 77/389 (19%), Positives = 167/389 (42%), Gaps = 59/389 (15%)
Query: 54 DEDDI--LKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKG-------- 103
DE D +K L+E+ E + K E +K +N+++ + +D ++G+
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITI 62
Query: 104 KKQSFDDNDSEELEDKDSKSKKTA-KPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWD 162
+ + DS +ED+ + A KP +M S + ++ +K K K + + +
Sbjct: 63 RNSPYRREDS--MEDRGEEDDSLAIKPPQQM---SRKEKVHHRKDEKRKEKCRHHSHSAE 117
Query: 163 GSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDAS 222
G + ++ + R R + E Q R+ + + +E +
Sbjct: 118 GGKHARVKEREHERRKRHREEQDKARREWE-RQKRREMAREHSRRERDRLEQLERKRERE 176
Query: 223 FKIKTVAQKKAEKKERERK---KRDEEKAKL---------------------------RK 252
K++ +++ E+KERER+ +R E +A+ R
Sbjct: 177 RKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRP 236
Query: 253 LKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGD 312
+E+ EL G+K ++K +R + ++ + A AE+ + +E++ E +
Sbjct: 237 PRERFELGDGRKPVKEEKMEERDLLSD-LQDISDSERKTSSAESSSAESGSGSEEEEEEE 295
Query: 313 KKKKDK-----KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE--ERQKREEEER 365
++++++ + ++ E+EE+E+E++ G + + +A +++ ++ EEE E ++RE E
Sbjct: 296 EEEEEEGSTSEESEEEEEEEEEEEEETGSN--SEEASEQSAEEVSEEEMSEDEERENENH 353
Query: 366 IKRLEELEAKRK--EEERLEQEKRERKKQ 392
+ + E R E E E+E E Q
Sbjct: 354 LLVVPESRFDRDSGESEEAEEEVGEGTPQ 382
Score = 42.4 bits (98), Expect = 0.003
Identities = 41/220 (18%), Positives = 101/220 (45%), Gaps = 3/220 (1%)
Query: 42 GKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQ 101
G +K K++ +E D+L +L+++S + + + A + + EEE ++++++G
Sbjct: 244 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGS 303
Query: 102 KGKK-QSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKK 160
++ + ++ + EE E+ S S++ ++ E S + +D + + +S
Sbjct: 304 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD 363
Query: 161 WDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDD 220
D S E E+ +++ E + +S+ GD + + K + K P ++ ++
Sbjct: 364 RD-SGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEE 422
Query: 221 ASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE 260
+ + + R + K+ +E L++LK ++E E
Sbjct: 423 FQC-LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE 461
Score = 33.5 bits (75), Expect = 1.3
Identities = 27/135 (20%), Positives = 58/135 (42%), Gaps = 23/135 (17%)
Query: 509 MASDEETEKVEGNKVHIEVKENPEEEEEEEE----EEEEDEESEEEEEEEGESEG----- 559
M ++++ KV+ ++ K+ +E+EE+ E + +D +S+ + EEGE
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
Query: 560 ---SEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERA----------- 605
+ ++ + D + +L KP ++MS + D ++E+
Sbjct: 61 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK 120
Query: 606 YDKAKRRIEKRRLEH 620
+ + K R +RR H
Sbjct: 121 HARVKEREHERRKRH 135
Score = 31.6 bits (70), Expect = 4.8
Identities = 30/149 (20%), Positives = 68/149 (45%), Gaps = 11/149 (7%)
Query: 11 DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ 70
DS + ++ +AE G+G+ +E+E ++ + ++ ++ + +E++ +E EE
Sbjct: 269 DSERKTSSAESSSAE-SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG---- 323
Query: 71 GIKADRETVAVKPTENNEEEFTSKDKKKKGQKG---KKQSFDDNDSEELEDKDSKSKKTA 127
++ E + + E EE S+D++++ + +S D DS E E+ + + +
Sbjct: 324 ---SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 380
Query: 128 KPKVEMYSGSDDDDDFNKLPKKAKGKAQK 156
+ G D LP + K + K
Sbjct: 381 PQSSALTEGDYVPDSPALLPIELKQELPK 409
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 127 bits (320), Expect = 5e-29
Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 36/396 (9%)
Query: 218 DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
D+ S+K+KT+ + EKK R+K EEKA++++LK ++ ++ K+D ++ E +
Sbjct: 3 DEKDSWKVKTLDEILQEKK---RRKEQEEKAEIKRLKNSDDRDS-KRDSLEEGELRDHRM 58
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD---KKKKKGEKEEKEKEKKK 334
E T+++ P E + EDD+ K + K+K K+EK KEK++
Sbjct: 59 EITIRNS--------PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRR 110
Query: 335 GPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKE 394
S + + + + E ER+KR EE+ K E E +++ E E +RER + ++
Sbjct: 111 HRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ 170
Query: 395 KERK---ERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKR 451
ERK ER +E + + Q+E RAE K +A+ EV + R Y DK +
Sbjct: 171 LERKRERERKMREQQKEQREQKERERRAEERRKEREARR-EVSAHHRT--MREDYSDKVK 227
Query: 452 KKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMAS 511
+ + E EL + P KEE E + D +D + D E S
Sbjct: 228 ASHWSRSPPRPPRERFELGDGRK------PVKEEKME--ERDLLSDLQD--ISDSERKTS 277
Query: 512 DEETEKVEGNKVHIEVKENPEEEEEE---EEEEEEDEESEEEEEEEGESEGSEGDEED-E 567
E+ E E +E EEEEEE EE EE+EE EEEEEEE S E E+ E
Sbjct: 278 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 337
Query: 568 KVSDEKDS-GKTLDKKPSKEMSSDSEYDSDDDRTKE 602
+VS+E+ S + + + + +S +D D ++E
Sbjct: 338 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 373
Score = 60.5 bits (145), Expect = 1e-08
Identities = 71/390 (18%), Positives = 166/390 (42%), Gaps = 59/390 (15%)
Query: 54 DEDDI--LKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQ---------- 101
DE D +K L+E+ E + K E +K +N+++ + +D ++G+
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITI 62
Query: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKW 161
+ +D+ + E+ DS + K + D+ K ++ + + + K
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHA 122
Query: 162 DGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDA 221
E++ ++ ++ + R + + + Q R+ + + +E +
Sbjct: 123 RVKEKEREHERRKRHREEQDKARREWER-----QKRREMAREHSRRERDRLEQLERKRER 177
Query: 222 SFKIKTVAQKKAEKKERERK---KRDEEKAKL---------------------------R 251
K++ +++ E+KERER+ +R E +A+ R
Sbjct: 178 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 237
Query: 252 KLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEG 311
+E+ EL G+K ++K +R + ++ + A AE+ + +E++ E
Sbjct: 238 PPRERFELGDGRKPVKEEKMEERDLLSD-LQDISDSERKTSSAESSSAESGSGSEEEEEE 296
Query: 312 DKKKKDK-----KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE--ERQKREEEE 364
+++++++ + ++ E+EE+E+E++ G + + +A +++ ++ EEE E ++RE E
Sbjct: 297 EEEEEEEGSTSEESEEEEEEEEEEEEETGSN--SEEASEQSAEEVSEEEMSEDEERENEN 354
Query: 365 RIKRLEELEAKRK--EEERLEQEKRERKKQ 392
+ + E R E E E+E E Q
Sbjct: 355 HLLVVPESRFDRDSGESEEAEEEVGEGTPQ 384
Score = 50.8 bits (120), Expect = 8e-06
Identities = 78/394 (19%), Positives = 152/394 (38%), Gaps = 71/394 (18%)
Query: 27 EGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTEN 86
EG A+ +E ++ ++K+ +++QD KA RE
Sbjct: 117 EGGKHARVKEKEREHERRKRHREEQD--------------------KARREW-------- 148
Query: 87 NEEEFTSKDKKKKGQKGKKQSFDDNDS-EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNK 145
+++K+ + ++ S + D E+LE K + +K + + E + + +
Sbjct: 149 --------ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERE---RR 197
Query: 146 LPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK 205
++ K + + ED S K+K S E E RK K +K
Sbjct: 198 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK-PVKEEK 256
Query: 206 NKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKD 265
+ + + D+ K + AE ++ +EE+ +E+EE T ++
Sbjct: 257 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE------EEEEEGSTSEES 310
Query: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK-KKKKGE 324
+ +++E + + EE S+ + SEE+ E++N + + + GE
Sbjct: 311 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 370
Query: 325 KEEKEKEKKKG----------------PSKATVKAMQEALAKLKEEEERQKREEEERIKR 368
EE E+E +G P+ + ++ QE L + + EE + + R
Sbjct: 371 SEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNR 430
Query: 369 LEE------LEAKRKEEERLEQEKRERKKQKEKE 396
+EE AK K+ + + KR K +KEKE
Sbjct: 431 IEEGTYGVVYRAKDKKTDEIVALKR-LKMEKEKE 463
Score = 42.4 bits (98), Expect = 0.003
Identities = 45/196 (22%), Positives = 83/196 (42%), Gaps = 29/196 (14%)
Query: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV--PEKEETPPPVEPEEEEDT-EDA 501
+ E K+RK+ ++ E K + S + + + +E+G + E P ED+ ED
Sbjct: 17 LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR 76
Query: 502 GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE---------------EEEEEEEEDEE 546
G +D +++A + KVH E +E+ +E+E E E +
Sbjct: 77 GEED-DSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRK 135
Query: 547 SEEEEEEEGESEGSEGDEED---EKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEE 603
EE+++ E + E E+D + L++K +E ++ KE+
Sbjct: 136 RHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM-------REQQKEQ 188
Query: 604 RAYDKAKRRIEKRRLE 619
R + +RR E+RR E
Sbjct: 189 REQKERERRAEERRKE 204
Score = 35.8 bits (81), Expect = 0.26
Identities = 31/137 (22%), Positives = 61/137 (44%), Gaps = 25/137 (18%)
Query: 509 MASDEETEKVEGNKVHIEVKENPEEEEEEEE----EEEEDEESEEEEEEEGESEGSEGD- 563
M ++++ KV+ ++ K+ +E+EE+ E + +D +S+ + EEGE +
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
Query: 564 -------EEDEKVSDEKDSGKTLDKKPSKEMS-SDSEYDSDDDRTKEER----------- 604
++ + D + +L KP ++MS + + D++ KE+R
Sbjct: 61 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
Query: 605 -AYDKAKRRIEKRRLEH 620
A K K R +RR H
Sbjct: 121 HARVKEKEREHERRKRH 137
Score = 35.0 bits (79), Expect = 0.44
Identities = 38/166 (22%), Positives = 75/166 (45%), Gaps = 29/166 (17%)
Query: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGL---DDWEAMASDEETEKVEGNKVHIEVKE 529
V+ +++ + EK+ E+EE E L DD ++ E ++ +++ I ++
Sbjct: 10 VKTLDEILQEKKR-----RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRN 64
Query: 530 NPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSS 589
+P E+ E+ E+++S + + S EKV KD K +K+ + S+
Sbjct: 65 SPYRREDSMEDRGEEDDSLAIKPPQQMSR-------KEKVHHRKDE-KRKEKRRHRSHSA 116
Query: 590 D-------SEYDSDDDRTKEER-AYDKAKRRIEKRR-----LEHSK 622
+ E + + +R K R DKA+R E+++ EHS+
Sbjct: 117 EGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSR 162
Score = 30.8 bits (68), Expect = 8.2
Identities = 24/115 (20%), Positives = 58/115 (50%), Gaps = 11/115 (9%)
Query: 11 DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ 70
DS + ++ +AE G+G+ +E+E ++ + ++ ++ + +E++ +E EE
Sbjct: 271 DSERKTSSAESSSAE-SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG---- 325
Query: 71 GIKADRETVAVKPTENNEEEFTSKDKKKKGQKG---KKQSFDDNDSEELEDKDSK 122
++ E + + E EE S+D++++ + +S D DS E E+ + +
Sbjct: 326 ---SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 377
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 127 bits (319), Expect = 6e-29
Identities = 130/595 (21%), Positives = 286/595 (48%), Gaps = 68/595 (11%)
Query: 47 EKKKQDFDEDDILKELEELSLEA-------QGIKAD----RETVAVKPTENNEEEFTSKD 95
+KKK D +++ KE + LSLE + +K +E + + +E +E + K+
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 96 KKKKGQKGKKQSFDDNDSEELE-DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKA 154
K+K ++ K ++L+ + D K+ ++ + ++++ +N+L +
Sbjct: 247 LKRKLERAKLLL----PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ------ 296
Query: 155 QKSNKKWDGSEEDEDNSKKIKERS-RINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIE 213
Q+ K W E+ ++ +KI+E+ +I E E +E ++ ++ ++ K E
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 214 SGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQ 273
E ++ + + + +K EK R+ + E++ K+R+L+EK + ++Q ++++ +
Sbjct: 357 MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE 416
Query: 274 RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK 333
K E+ + E++A+ E E ++K ++++KK +EEK E++
Sbjct: 417 EKIREQEKRQ------------EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 464
Query: 334 KGPSKATVKAMQEALAKLKEEEERQKREE----EERIKRLEELEAKRKEEERLEQEKRER 389
K ++EEE+RQ++EE EE+I EE+ R++E+ EQE++ R
Sbjct: 465 K----------------IREEEKRQEQEEMWRQEEKIHEQEEIW--RQKEKMHEQEEKIR 506
Query: 390 KKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDK 449
K++++ R+E +E + + Q E R E ++ + E ++ + ++ I+E++
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWRE---EEKMHEQEKIWEEE 563
Query: 450 KRKKIPQQL--ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507
KR++ ++ + +++ E E V E+ + E+EE E EE+ ++ + + E
Sbjct: 564 KRQEQEDKMWRQEEKIREQEE---KVWRQEEKIREQEEKRQ--EQEEKMWKQEEKIREQE 618
Query: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567
++E EK+ + I +E +E+EE+ E+E++ E+EE+ + + E EE
Sbjct: 619 EKIQEQE-EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677
Query: 568 KVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
+ ++K + + +EM + E + K +K + + EK R + K
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732
Score = 95.1 bits (235), Expect = 4e-19
Identities = 78/405 (19%), Positives = 205/405 (50%), Gaps = 29/405 (7%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
+++E K +K + +++ +++++ ++ EE+ E + + E + + E+E
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
++++K ++ K+Q + + E + +K + + +M+ + + K+ ++ K
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 472
Query: 153 KAQ-----------KSNKKWDGSEEDEDNSKKI-KERSRINSSGESGDESDEFLQSRKGQ 200
+ Q + + W E+ + +KI K+ ++ E E +E ++ ++ +
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Query: 201 KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE 260
Q+ K E E++ K Q+K ++E+ +++ D+ + K++E+EE
Sbjct: 533 MWRQEEKIREQEEMWREEE------KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586
Query: 261 TGKKDQSKQKESQRKFEEETV---KSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD 317
++++ +++E +R+ +EE + + K+ I EEK E E ++ ++
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIR--EQEEKIREQEEMTQE 644
Query: 318 KKKKKGEKEEK--EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAK 375
+++K GE+EEK E+E+K + T+ +E + E+E++ RE+EE+I+ EE+ +
Sbjct: 645 QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI----REQEKKIREQEEKIREQEEMMQE 700
Query: 376 RKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE 420
++E+ ++EK +++K +E++E+++++ + + + + R + E
Sbjct: 701 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Score = 89.0 bits (219), Expect = 3e-17
Identities = 80/396 (20%), Positives = 197/396 (49%), Gaps = 46/396 (11%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
+++E K +K + +++ +++++ ++ELEE E + I+ E + EEE
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE-------KRQEEEKI 419
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPK---- 148
+ +K++ Q+ K ++ E+ E + KK + + +++ ++ + +
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 479
Query: 149 KAKGKAQKSNKKWDGSEEDEDNSKKI-KERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207
+ + K + + W E+ + +KI K+ ++ E E +E ++ ++ + Q+ K
Sbjct: 480 RQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK 539
Query: 208 PGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQS 267
E E++ K Q+K ++E+ +++ D+ + K++E+EE ++++
Sbjct: 540 IREQEEMWREEE------KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKI 593
Query: 268 KQKESQRKFEEETV---KSKVTVDTGVIPASEEKA----------ETPTAAEDDNEGDKK 314
+++E +R+ +EE + + K+ I EEK E T +++ G+++
Sbjct: 594 REQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE 653
Query: 315 KK--DKKKKKGEKEE---------KEKEKKKGPSKATVKAMQEALAKLKE---EEERQKR 360
+K ++++K E+EE +E+EKK + ++ +E + + +E E+E +
Sbjct: 654 EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 713
Query: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKE 396
E+EE+++ EE + +R+EE+ EQE R R+++++ +
Sbjct: 714 EQEEKMQEQEE-KMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 87.0 bits (214), Expect = 1e-16
Identities = 91/457 (19%), Positives = 223/457 (48%), Gaps = 43/457 (9%)
Query: 34 EQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTS 93
E++ Q+ + K +++++K E+ + ++ E + + + ++ E + K + +E
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 372
Query: 94 KDKKKKGQKGKKQSFDDNDS-EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
+K++K ++ ++ ++ + ELE+K + +K + + + + K+ ++ K
Sbjct: 373 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE-------EKRQEEEKIREQEKR 425
Query: 153 KAQKSNKKWDGSEEDEDNSKKIKERSR-INSSGESGDESDEFLQSRKGQKKNQKNKPGPN 211
+ Q++ K W E+ + +KI+E+ + + E E ++ + K Q++ + +
Sbjct: 426 QEQEA-KMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 212 I----------ESGNEDDDASFKIKTVAQKKAEK-KERERKKRDEEKAKLR---KLKEKE 257
I E +E ++ K + ++ EK +E+E K R++E+ R K++E+E
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544
Query: 258 ELETGKKDQSKQKESQRKFEEE---TVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKK 314
E+ +++ K E ++ +EEE + K+ I EEK E E ++K
Sbjct: 545 EM---WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW--RQEEKIREQEEK 599
Query: 315 KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEE---ERIKRLEE 371
++++++K ++EEK +E++ + +QE K++E+EE+ + +EE E+ +++ E
Sbjct: 600 RQEQEEKMWKQEEKIREQE--------EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE 651
Query: 372 LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV 431
E K E+E QE+ E ++E++ +E+ KK + K + + E K+ + +
Sbjct: 652 QEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 711
Query: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESME 468
++ + ++ ++ K Q++ ++ E M+
Sbjct: 712 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 71.6 bits (174), Expect = 4e-12
Identities = 91/445 (20%), Positives = 189/445 (42%), Gaps = 77/445 (17%)
Query: 178 SRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
SR++ S + E ++ L + QKK K IE ++ DA ++ +++
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKK----KADRYIEELTKERDA-LSLELYRNTITDEEL 219
Query: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE 297
+E+ + +EK +L + EK E+ Q KE +RK E + ++P +
Sbjct: 220 KEKNAKLQEKLQLVE-SEKSEI------QLNVKELKRKLERAKL---------LLPQQQL 263
Query: 298 KAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER 357
+AE D+ G + + K + + EE E + Q+ K+ +EE+
Sbjct: 264 QAEA------DHLGKELQSVSAKLQAQVEENELWNRLN---------QQQEEKMWRQEEK 308
Query: 358 QKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARA 417
+ E EE+I+ EE +++E+ R ++EK R+++ E++E+++++ +++ + + + R
Sbjct: 309 IQ-EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 418 RAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVME 477
+ E + E+K R++ E +E +E
Sbjct: 368 QEEMMWEK---------------------EEKMRRQEEMMWEKEEKIRELE--------- 397
Query: 478 QGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE 537
EK + +EE+ E+ + + E E + K+ + ++ E+E++
Sbjct: 398 ----EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 453
Query: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597
+EE+ E E+ EEE E E ++EK+ ++++ + KE + E
Sbjct: 454 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR------QKEKMHEQEEKIRK 507
Query: 598 DRTKEERAYDKAKRRIEKRRLEHSK 622
K R +K + + EK R + K
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEK 532
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 125 bits (314), Expect = 2e-28
Identities = 116/404 (28%), Positives = 181/404 (44%), Gaps = 78/404 (19%)
Query: 218 DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
D+ S+K+KT+ + EKK R+K EEKA++++LK ++ ++ K+D ++ E +
Sbjct: 3 DEKDSWKVKTLDEILQEKK---RRKEQEEKAEIKRLKNSDDRDS-KRDSLEEGELRDHCM 58
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD---KKKKKGEKEEKEKEKKK 334
E T+++ P E + EDD+ K + K+K K+EK KEKK
Sbjct: 59 EITIRNS--------PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKH 110
Query: 335 GPSKATV------KAMQEALAKLKEEEERQKREEEERIK---------------RLEELE 373
K K +E K + E ERQKR E R RLE+LE
Sbjct: 111 ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLE 170
Query: 374 AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEV 433
KR+ E ++ ++++E+++QKE+ER+ +++ +REAR A + +
Sbjct: 171 RKRERERKMREQQKEQREQKERERRAEERRK-------EREARREVSAHHRTM------- 216
Query: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493
R Y DK + + + E EL + P KEE E +
Sbjct: 217 ---------REDYSDKVKASHWSRSPPRPPRERFELGDGRK------PVKEEKME--ERD 259
Query: 494 EEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553
D +D + D E S E+ E E +E EEEEEE EE EE EEEEEE
Sbjct: 260 LLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 317
Query: 554 EGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597
E E GS +E E+ ++E +EMS D E ++++
Sbjct: 318 EEEETGSNSEEASEQSAEEVS---------EEEMSEDEERENEN 352
Score = 66.2 bits (160), Expect = 2e-10
Identities = 79/387 (20%), Positives = 176/387 (45%), Gaps = 55/387 (14%)
Query: 54 DEDDI--LKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQ---------- 101
DE D +K L+E+ E + K E +K +N+++ + +D ++G+
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITI 62
Query: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKA-QKSNKK 160
+ +D+ + E+ DS + K + D+ K K A+ K ++ +++
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER 122
Query: 161 WDGSEEDEDNSK------KIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIES 214
E++D ++ K +E +R +S E G++ + R Q + ++ + E
Sbjct: 123 RKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQ 182
Query: 215 GNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKE--KEELETGKKDQSKQKES 272
E + + +++AE++ +ER+ R E A R ++E ++++ +S +
Sbjct: 183 QKEQREQKER-----ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237
Query: 273 QRKFE----------EETVKSKVTVDTGVIPASEEK--------AETPTAAEDDNEGDKK 314
+ +FE E+ + + D I SE K AE+ + +E++ E +++
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 297
Query: 315 KKDK-----KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE--ERQKREEEERIK 367
++++ + ++ E+EE+E+E++ G + + +A +++ ++ EEE E ++RE E +
Sbjct: 298 EEEEGSTSEESEEEEEEEEEEEEETGSN--SEEASEQSAEEVSEEEMSEDEERENENHLL 355
Query: 368 RLEELEAKRK--EEERLEQEKRERKKQ 392
+ E R E E E+E E Q
Sbjct: 356 VVPESRFDRDSGESEEAEEEVGEGTPQ 382
Score = 58.5 bits (140), Expect = 4e-08
Identities = 88/412 (21%), Positives = 160/412 (38%), Gaps = 41/412 (9%)
Query: 8 KSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSL 67
+ EDS +D + D A +++++ K +K+KEKK E + E +
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 68 EAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTA 127
E Q KA RE K E E ++++G G D LE + K ++
Sbjct: 128 EEQD-KARREWERQKRREMAREH----SRRERGNDGVCLFRD-----RLEQLERKRERER 177
Query: 128 KPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESG 187
K + + + + + ++ K + + ED S K+K S
Sbjct: 178 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237
Query: 188 DESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEK 247
E E RK K +K + + + D+ K + AE ++ +EE+
Sbjct: 238 RERFELGDGRK-PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 296
Query: 248 AKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAED 307
+E+EE T ++ + +++E + + EE S+ + SEE+ E+
Sbjct: 297 ------EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 350
Query: 308 DNEGDKKKKDK-KKKKGEKEEKEKEKKKG----------------PSKATVKAMQEALAK 350
+N + + + GE EE E+E +G P+ + ++ QE
Sbjct: 351 ENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKY 410
Query: 351 LKEEEERQKREEEERIKRLEE------LEAKRKEEERLEQEKRERKKQKEKE 396
L + + EE + + R+EE AK K+ + + KR K +KEKE
Sbjct: 411 LPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKR-LKMEKEKE 461
Score = 43.5 bits (101), Expect = 0.001
Identities = 47/193 (24%), Positives = 84/193 (43%), Gaps = 25/193 (12%)
Query: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE--ETPPPVEPEEEEDT-EDA 501
+ E K+RK+ ++ E K + S + + + +E+G E P ED+ ED
Sbjct: 17 LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDR 76
Query: 502 GLDDW-------EAMASDEET----EKVEGNKVHIEVKENPEEEEEE----EEEEEEDEE 546
G +D + M+ E+ ++ K H VKE E E EE+++ E
Sbjct: 77 GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARRE 136
Query: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAY 606
E ++ E E S + ++ V +D + L++K +E ++ KE+R
Sbjct: 137 WERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKM-------REQQKEQREQ 189
Query: 607 DKAKRRIEKRRLE 619
+ +RR E+RR E
Sbjct: 190 KERERRAEERRKE 202
Score = 39.3 bits (90), Expect = 0.023
Identities = 29/126 (23%), Positives = 60/126 (47%), Gaps = 14/126 (11%)
Query: 509 MASDEETEKVEGNKVHIEVKENPEEEEEEEE----EEEEDEESEEEEEEEGESEG----- 559
M ++++ KV+ ++ K+ +E+EE+ E + +D +S+ + EEGE
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60
Query: 560 ---SEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE--YDSDDDRTKEERAYDKAKRRIE 614
+ ++ + D + +L KP ++MS + + D+ R +++ A K K R
Sbjct: 61 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREH 120
Query: 615 KRRLEH 620
+RR H
Sbjct: 121 ERRKRH 126
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 124 bits (312), Expect = 4e-28
Identities = 124/609 (20%), Positives = 285/609 (46%), Gaps = 80/609 (13%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
+++E + + KK ++++++ + +++ L+E +E + Q K R+ K E+E
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERLRE-QEGKMREQEEKMWRQE---KRLREQEKELR 331
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
++K+ + QK ++ + +E E+K + ++ +
Sbjct: 332 EQEKELREQKELREQ--EEQMQEQEEKMWEQEEKMR------------------------ 365
Query: 153 KAQKSNKKWDGSEEDEDNSKKIKER-SRINSSGESGDESDEFLQSRKGQKKNQKNKPGPN 211
++ K W E + K+++E+ ++ E E DE L+ K ++ ++ K
Sbjct: 366 --EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR-EKEERMREQEKMWEQ 422
Query: 212 IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSK-QK 270
+E E+ K + +++ + +++E K ++EE+ + R+ K +EE ET ++ + K QK
Sbjct: 423 VEKMREE-------KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475
Query: 271 ESQRKFEEE----------TVKSKVTVDTGVIPASEEKAETPTAAEDDNE--GDKKKKDK 318
+ + +E+E K K+ + E+ E D E G +KK +
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 319 KKKKGEKEEK--EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK---RLEELE 373
++K E+E++ E+E+K + + +E + K +E+E++ ++EE+++ R+ E E
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
Query: 374 AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEV 433
K +EEE + +E+ E+ +++E++ +E+ +K + K Q + E K+ +
Sbjct: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE------ 649
Query: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493
++ ++E ++++P+Q E E M+ ++ E+ + E+E+ + +
Sbjct: 650 -------QEEKMWE---QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Query: 494 EEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553
E++ + + + E+M E+ + E E+ EE+ +E+EE+ +++E E E+E
Sbjct: 700 EKKTWDQEKMREEESMREREKKMREEE-----EMMREQEEKMQEQEEKMQEQEEEMWEQE 754
Query: 554 EGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRI 613
E E E E +++ ++K+ +K +E + E D K +K + +
Sbjct: 755 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE 814
Query: 614 EKRRLEHSK 622
EK R + K
Sbjct: 815 EKMRGQEEK 823
Score = 117 bits (293), Expect = 7e-26
Identities = 126/556 (22%), Positives = 266/556 (47%), Gaps = 68/556 (12%)
Query: 34 EQEPQ-KSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
EQE Q + + +K ++++++ +++D+ L+E EE E + + E + + +E+ T
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
++K ++ + + + EE E + +K K + M+ + + +LP
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP----- 494
Query: 153 KAQKSNKKWDGSEEDEDNSKKIKERSRINSSGES-GDESDEFLQSRKGQKKNQKNKPGPN 211
++ K W+ + E K ++ +I E G E + Q + ++++Q +
Sbjct: 495 --EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552
Query: 212 IESGNE---DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSK 268
+ + D + + KT Q+K + ++E K R+EE+ + R+ K +EE E ++ + K
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEK-KTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 269 QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK 328
+E + K +E+ K + EEK + E ++K ++++K E+EEK
Sbjct: 612 MQEQEEKMQEQEEK---------MWEQEEKMQ---------EQEEKMWEQEEKMWEQEEK 653
Query: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERL--EQEK 386
E+++ P + E K++E+E+ Q E+EE+I E++E K +E+E+ +QEK
Sbjct: 654 MWEQQRLPEQKEKLWEHE---KMQEQEKMQ--EQEEKIWEQEKMEKKTQEQEKKTWDQEK 708
Query: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIY 446
R+++ +ER++++++E +++ + + + + + E +Q Q E+ ++ +K
Sbjct: 709 M-REEESMREREKKMREEEEMMREQEEKMQEQEEK----MQEQEEEMWEQE---EKMWEQ 760
Query: 447 EDK--KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE---EEEDTEDA 501
E+K +++++P+Q E E M+ + E+ + ++EE E + +EE
Sbjct: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820
Query: 502 GLDDW---EAMASDEET-----EKVEGNKVHIEVKENPEEEEEEEEEEE---------ED 544
W E M EE EK+ G + +E K +EE+ E+EE+ E
Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
Query: 545 EESEEEEEEEGESEGS 560
EE +EE+ GS
Sbjct: 881 EEKMRGQEEKIYCVGS 896
Score = 115 bits (289), Expect = 2e-25
Identities = 127/621 (20%), Positives = 285/621 (45%), Gaps = 67/621 (10%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
+EQE + + +K+ ++K+ ++++ ++E EE E + ++E + EE
Sbjct: 324 REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE----EKMWRQEERLW 379
Query: 93 SKDKKKKGQKGKKQSFDDN---DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKK 149
++K+ + Q+ K + ++ E L +K+ + ++ K ++ ++
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEK--------- 430
Query: 150 AKGKAQKSNKKWDGSEEDEDNSKKIKERSR-INSSGESGDESDEFLQSRKGQKKNQKNKP 208
K Q+ KK EE ++I+ER + + E+ E +E +Q ++ Q+ K
Sbjct: 431 ---KMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
Query: 209 GPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKA--------KLRKLKEKEELE 260
+ E + ++ + + +++ + E+E K RD+E+ + K++E+E+
Sbjct: 488 WQQ-QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 261 TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKK 320
++++ + +E + +EE ++ K EEK + + +++++ +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 321 KKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE 380
++ EK ++++EK MQE K+ E+EE+ + +EE+ + +EE+
Sbjct: 607 EQEEKMQEQEEK-----------MQEQEEKMWEQEEKMQEQEEKMWE---------QEEK 646
Query: 381 RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLP 440
EQE++ ++Q+ E+KE+L + K+ +E E K+ + + +E +++
Sbjct: 647 MWEQEEKMWEQQRLPEQKEKLWEHEKM-----QEQEKMQEQEEKIWEQEKMEKKTQEQ-- 699
Query: 441 KKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTED 500
+K+ ++K R++ + K++ E E+ E Q EK + E+EE +
Sbjct: 700 EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWE 759
Query: 501 AGLDDWEAMASDEETEKV-EGNKVHIEVKENPEEEEEEEEEE----EEDEESEEEEEEEG 555
WE E+ EK+ E K+ + K +EE+ ++EE +E++ +EE+ G
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRG 819
Query: 556 ESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEK 615
+ E G EE +EK G+ +K +E + + +++ +E+ +K + + EK
Sbjct: 820 QEEKMWGQEEKMWGQEEKMWGQE-EKMWGQEEKMEEKMQGQEEKMREQE--EKMRGQEEK 876
Query: 616 RRLEHSKNVNTEKLRAPIICV 636
R + K E+ I CV
Sbjct: 877 MREQEEKMRGQEE---KIYCV 894
Score = 108 bits (270), Expect = 3e-23
Identities = 120/619 (19%), Positives = 282/619 (45%), Gaps = 77/619 (12%)
Query: 36 EPQKSKGKKKKEKKKQDFDEDDILKELEELSLEA-------QGIKAD----RETVAVKPT 84
E Q++ KK D +++ KE + LSLE + +K +E + + +
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 85 ENNEEEFTSKDKKKKGQKGK---KQSFDDNDSEEL----EDKDSKSKKTAKPKVEMYSGS 137
E +E + K+ K+K ++ K Q + EE+ E+ + KK K + +M+
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197
+ +L ++ ++ K W + + K+++E+ + E ++ + L+ +
Sbjct: 300 E------RLREQEGKMREQEEKMWRQEKRLREQEKELREQEK-----ELREQKE--LREQ 346
Query: 198 KGQKKNQKNKPGPNIESGNEDDDASFKIKT-VAQKKAEKKERERKKRDEEKAKLRKLKEK 256
+ Q + Q+ K E E ++ ++ + + +++ + +E+E+K RD+E+ + +
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
Query: 257 EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK 316
E E ++Q K E K EE KK +
Sbjct: 407 REKEERMREQEKMWEQVEKMREE---------------------------------KKMQ 433
Query: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE----EERIKRLEEL 372
+++KK ++EEK +E+++ + K M+E ++E+EE+ +++E E+ K ++
Sbjct: 434 EQEKKTRDQEEKMQEEER--IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 373 EAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVE 432
++E+ EQEK + +++K E++E+++ + ++ + ++ R + ++ + Q E
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR---QEKMREQEDQMWE 548
Query: 433 VPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP 492
K +++ ++++ +K Q+ E K + ++ + E+ +EE E
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ 608
Query: 493 EEE-EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEE 551
EE+ ++ E+ + E M EE + + K+ + ++ E+EE+ E++ E+ E+
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
Query: 552 EEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDS--EYDSDDDRTKEERAYDKA 609
E E E + E++EK+ +++ K ++ K + E +S +R K+ R ++
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 610 KRRIEKRRLEHSKNVNTEK 628
R E++ E + + ++
Sbjct: 729 MREQEEKMQEQEEKMQEQE 747
Score = 92.4 bits (228), Expect = 2e-18
Identities = 142/677 (20%), Positives = 282/677 (41%), Gaps = 99/677 (14%)
Query: 11 DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ 70
D+ K I+ G ++ Q+++ + K+EKK ++ + +E+E
Sbjct: 46 DTKKKKINHGTNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIE------- 98
Query: 71 GIKADRETVAVKPTENNEEE---FTSKDKKKK---GQKGKKQSFDDNDSEELEDKDSKSK 124
A T+ + + E E + S+D +K G G SF+ S+
Sbjct: 99 ---AQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCV 155
Query: 125 KTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSG 184
T+ +P ++K A + + W + E + + R +
Sbjct: 156 STSL-----------------IPGESKDLAGRLHHSWHFAGELQRALSAVSTRHK----- 193
Query: 185 ESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK-KR 243
++ +E + R N E ++ + K+ +K+E + ++ KR
Sbjct: 194 KADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKR 253
Query: 244 DEEKAKL------------RKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
E+AK +++EEL +K KQ+E + EE ++ G
Sbjct: 254 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE-----RLREQEGK 308
Query: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351
+ EEK ++ +++K+ ++++K +E+KE +++ + + M E K+
Sbjct: 309 MREQEEKMWR----QEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKM 364
Query: 352 KEEEERQKREEE---ERIKRLEELEAK-RKEEERL--------EQEKRERKKQK-----E 394
+E+EE+ R+EE E+ K++ E E K R +EER+ E+E+R R+++K E
Sbjct: 365 REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVE 424
Query: 395 KERKERLKKEGKLLT-----KSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP-IYED 448
K R+E+ +E + T K Q E R R E K+ + + ++ + K+ ++E
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIR-EREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 449 KKR----KKIPQQLESKEVSESM-ELCAAVEVMEQGVPEKEE----TPPPVEPEEEEDTE 499
+++ +++P+Q E E M E + E+ + ++EE E+ + E
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
Query: 500 DAGLDDWEAMASDE-----ETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEE 554
D + E M E + E++E E K +EE+ EEE + E + EEEE
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 555 GESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIE 614
E E +E E+ E++ ++ +E + +EE+ +++ + +
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
Query: 615 KRRL-EHSKNVNTEKLR 630
K +L EH K EK++
Sbjct: 664 KEKLWEHEKMQEQEKMQ 680
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 124 bits (312), Expect = 4e-28
Identities = 140/629 (22%), Positives = 274/629 (43%), Gaps = 90/629 (14%)
Query: 56 DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
DD + E + + ++ + E +A + +++EEE + +++ Q+ +Q ++ +
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 116 LEDKDSKSKKTAKPKVEMYSGS-----DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
+ D+ + + + P E + + + DD+ L + A+ + ++ + + E ++
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQ 230
I + S S +++ E + K +K + + + + + + Q
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE--------RYEIEETETVTKSYQ 173
Query: 231 KKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSK-----V 285
K + E KK D+EK E+EE E K+ + + + EE+T +S+ +
Sbjct: 174 KNDWRDAEENKKEDKEK-------EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVM 226
Query: 286 TVDTGVIPASEEKAETPTAAEDDN--------EGDKKKKDKKKKKGEKEEKEK-----EK 332
++ G I + E K E D E DK++ + ++ + E EE+E+ +K
Sbjct: 227 SLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK 286
Query: 333 KKGPSKATVKAMQEALAKLKEEEERQKREE-EERIKRLEELEAKRKEEERLEQEKRERKK 391
K +A ++A ++A A+ +E E ++RE E KR E + KEEE+ E+R+R K
Sbjct: 287 KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
Query: 392 QKEK---ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYED 448
++EK E ++R+K+E K + ++ ARA E K+ + + +K KK + E
Sbjct: 347 EEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR----NKQLEEKKHAMQET 402
Query: 449 K-KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK--EETPPPVEPEEEEDTEDAG--- 502
K K +K+ Q++E K V+E A + ++ V +K EE V+ + E+ ED
Sbjct: 403 KIKGEKVEQKIEGKWVNEKK---AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
Query: 503 ---LDDWEAMASDEETEKVEG----NKVHIEVKENPEE---------------------- 533
+ D + E E+V+ K EVK E
Sbjct: 460 KEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519
Query: 534 ---EEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSD 590
E E + E + EE GE+E E ++ +K ++++ L++ K
Sbjct: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK---QQEAALELEELKKKREERR 576
Query: 591 SEYDSDDDRTKEERAYDKAKRRIEKRRLE 619
+ ++ R K+E A K + EKRRL+
Sbjct: 577 KVLEEEEQRRKQEEADRKLREEEEKRRLK 605
Score = 109 bits (273), Expect = 1e-23
Identities = 139/639 (21%), Positives = 287/639 (44%), Gaps = 85/639 (13%)
Query: 14 KDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIK 73
++++ L+A + +E+ ++ + + ++E+ +Q +E+ + + +++ + AQ
Sbjct: 15 REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSV 74
Query: 74 ADRE----TVAVKPTENNEEEFTSKDKKKKGQKGKK--------QSFD------------ 109
D E T + ++E F + +++ ++ K+ + FD
Sbjct: 75 PDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPS 134
Query: 110 ---DNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEE 166
ND+ E E + + K ++ E Y ++ + K +K + + NKK D +E
Sbjct: 135 RRMQNDTAENETTEKEEKSESRQ--ERYE-IEETETVTKSYQKNDWRDAEENKKEDKEKE 191
Query: 167 DEDNSK----KIKERSRINSSGESGDESDE---FLQSRKGQKKNQKNKPGPNIESGN--- 216
+E+ K I E E ES E + + GQ +++ K E G+
Sbjct: 192 EEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEI 251
Query: 217 ------EDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK 270
E++D A+ +AE++ER + ++D++ A R E EE ++ + ++
Sbjct: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREA 311
Query: 271 ESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
E + + EE + A+EE+ + E ++ K+++K+ E+ ++ K
Sbjct: 312 EERERMREEEKR-----------AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360
Query: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAK-RKEEERLEQE-KRE 388
E++K ++ +A E K K EE+++ ++ EE+ ++E + K K E+++E + E
Sbjct: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420
Query: 389 RKKQKEKERKERLKKEGK---LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR-P 444
+K Q++K + LKK+G+ +++RE + T K + + ++ KD PK+
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKI-KKDKEPKEEVK 479
Query: 445 IYEDKKR----------KKIPQQLESKEVSESME-LCAAVEVME-QGVPEKEETPPPVEP 492
+ D+K+ + + +L+ E + S A+V+ E +G P+ E E
Sbjct: 480 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 539
Query: 493 EEEE-DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEE 551
+TE + + + E E K E ++ EEEE+ ++EE D + EEE
Sbjct: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 599
Query: 552 E-----EEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSK 585
E EE E +E E+ +K+ ++ G + DKKP K
Sbjct: 600 EKRRLKEEIERRRAEAAEKRQKMPED---GLSDDKKPFK 635
Score = 92.8 bits (229), Expect = 2e-18
Identities = 93/412 (22%), Positives = 191/412 (46%), Gaps = 57/412 (13%)
Query: 8 KSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKK----------EKKKQDFDEDD 57
K E+ K+ + + E E K ++ +K ++ + E+++++ +E +
Sbjct: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315
Query: 58 ILKELEELSL-EAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEEL 116
++E E+ + E Q IK + + A + EEE + +++++ ++ +K++ ++
Sbjct: 316 RMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARA 375
Query: 117 EDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKE 176
E+++ K KVE + ++ ++ K K +K +K +G +E +++ K
Sbjct: 376 EEEE-------KAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKL 428
Query: 177 RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKK 236
++ + + G+E +Q+++ +K Q++KP KK E K
Sbjct: 429 QTAVLK--KQGEEKGTKVQAKR--EKLQEDKP--------------------TFKKEEIK 464
Query: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE 296
+ + KK E K +++ ++++ T K Q+ E T K K T +T P
Sbjct: 465 DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG--------EFMTHKLKHTENTFSRPGGR 516
Query: 297 EKAETPTA-AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE 355
+T A E K+ ++ ++++GE E +E EK K + ++E K K EE
Sbjct: 517 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE--LKKKREE 574
Query: 356 ERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKL 407
R+ EEEE+ ++ EE + K +EEE EKR K++ E+ R E +K K+
Sbjct: 575 RRKVLEEEEQRRKQEEADRKLREEE----EKRRLKEEIERRRAEAAEKRQKM 622
Score = 92.4 bits (228), Expect = 2e-18
Identities = 96/415 (23%), Positives = 183/415 (44%), Gaps = 61/415 (14%)
Query: 235 KKERERKKRDEEKAKLRKLK------EKEELETGKKDQSKQKESQRKFEEET---VKSKV 285
++E R+KR+E + + ++ ++EE ++ +++Q+ ++K EEE+ V +V
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
Query: 286 TVDT-GVIPASEEKAETP-TAAEDDNEGD----KKKKDKKKKKGEKEEKEKEKKKGPSKA 339
V+ +P E K T T E D+E +++++++K +E E++K+ P+
Sbjct: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
Query: 340 TV------KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK 393
+ MQ A+ + E+ +K E + +EE E K ++ + E K++
Sbjct: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKE 186
Query: 394 EKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK 453
+KE++E +++ K + + + E Q + V + K+
Sbjct: 187 DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNG--------------- 231
Query: 454 IPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASD- 512
Q+ S+E + E EQG E E EEED E A + A +
Sbjct: 232 ---QISSEEPKQEEE-------REQGSDEISHH----EKMEEEDKERAEAERARLEAEER 277
Query: 513 -----EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567
E+ +K+ + IE +E +E E E EE E EEE+ E E EE++
Sbjct: 278 ERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE-ERQRIKEEEK 336
Query: 568 KVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
+ ++E+ K +K+ ++E E ++ R EER +A+ EK ++E K
Sbjct: 337 RAAEERQRIKEEEKRAAEERQRIKE---EEKRAAEERQRARAEEE-EKAKVEEQK 387
Score = 82.8 bits (203), Expect = 2e-15
Identities = 92/452 (20%), Positives = 197/452 (43%), Gaps = 46/452 (10%)
Query: 6 KNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEEL 65
+ K+ +S ++ + + +I +E+E ++ + +K ++ ED E E
Sbjct: 213 EEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEE--EDKERAEAERA 270
Query: 66 SLEAQG---IKADRET-VAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
LEA+ IKA+++ +A + EE + ++++ + +++ + + E++
Sbjct: 271 RLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQR 330
Query: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
++ + E +++ + ++ K + +++ ++ + +E+ K++E+ R
Sbjct: 331 IKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390
Query: 182 SSGESGDESDEFLQSRKGQKKNQKNK-PGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
E E KG+K QK + N + ED + +K ++K K + +R
Sbjct: 391 QLEEKKHAMQE--TKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKR 448
Query: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKES------------QRKFEEETVKSKVTVD 288
+K E+K +K + K+E K+ ++ +S + E T K K T +
Sbjct: 449 EKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTEN 508
Query: 289 TGVIPASEEKAETPTA-AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKAT------V 341
T P +T A E K+ ++ ++++GE E +E EK K + +
Sbjct: 509 TFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEEL 568
Query: 342 KAMQEALAKLKEEEE---------RQKREEEERIKRLEELEAKRKE---------EERLE 383
K +E K+ EEEE R+ REEEE+ + EE+E +R E E+ L
Sbjct: 569 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 628
Query: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREA 415
+K+ K K ++++ + L KS +++
Sbjct: 629 DDKKPFKCFTPKGSSLKIEERAEFLNKSVQKS 660
Score = 72.4 bits (176), Expect = 2e-12
Identities = 76/348 (21%), Positives = 150/348 (43%), Gaps = 29/348 (8%)
Query: 313 KKKKDKKKKKGEKEEKEKEK--KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE 370
+++++ +++K E+ E E+ + +A +E + ++E RQK+EEE + +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 371 ELEAKRK-----EEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKL 425
++E + EE + + + E ERL + + K +EA R +
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 426 LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEE 485
+ + +PS+ +K +K + E E+ E+ + + + + E+ +
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
Query: 486 TPPPVEPEEEEDTEDAGL---DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEE 542
+ EEEE+ G + E M ++ TE E V EE ++EEE
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
Query: 543 E---DEESEEEEEEEGESEGSEGD--------------EEDEKVSDEKDSGKTLDKKPSK 585
E DE S E+ EE + E +E + E+D+K++DE+ + +K ++
Sbjct: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ 304
Query: 586 EMSSDSEYDSDDDRTKEERAYDKAKR--RIEKRRLEHSKNVNTEKLRA 631
E + + R +E+RA ++ +R EKR E + + E+ RA
Sbjct: 305 ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 352
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 121 bits (303), Expect = 5e-27
Identities = 143/667 (21%), Positives = 308/667 (46%), Gaps = 86/667 (12%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
KK E+ TK+ DAL+ E+ +E +K + +++ + + ++ +I +
Sbjct: 155 KKADRYIEELTKER---DALSLELY-RNTITNEELKKKNAELQEKLRLAESEKSEIQLNV 210
Query: 63 EELSLEAQGIKADRETVAVKPTENN----EEEFTSKDKKKKGQKGKKQSFDDNDSEE--- 115
+EL + + K V + EEE ++KK + Q+ K ++ E+
Sbjct: 211 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGK 270
Query: 116 LEDKDSKSKKTAK----PKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNS 171
+ +++ K ++ K + E+ + + KL ++ + ++ K W+ E+ +
Sbjct: 271 MREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE 330
Query: 172 KKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231
+K+ + +E L ++ Q + Q+ K E E D+ + + ++
Sbjct: 331 EKMWRQ-------------EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 377
Query: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSK-QKESQRKFEEETV--------- 281
+ + E+E K ++EE+ + R+ K +EE ET ++ + K QK+ + +E+E
Sbjct: 378 QEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 437
Query: 282 -KSKVTVDTGVIPASEEKAETPTAAEDDNE--GDKKKKDKKKKKGEKEEKEKEKKKGPSK 338
K K+ + E+ E D E G +KK +++K E+E++ E+++
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE---- 493
Query: 339 ATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK 398
M++ K+ ++EER E++ER++ EE ++K+ + E++ RE KK +E+E+K
Sbjct: 494 ----KMRDQEQKMWDQEERMW-EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK 548
Query: 399 -----ERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK 453
E++++E ++ +RE + R E + Q + K E+K R++
Sbjct: 549 TWDQEEKMREEERM---REREKKMREEEEMMREQEE------------KMQEQEEKMREQ 593
Query: 454 IPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDE 513
+ E +E ++ E+ + E+EE E E++ ++ + + E ++
Sbjct: 594 EEKMWEQEE---------KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
Query: 514 ETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573
E + E + E +E E+EE+ + +EE + E+EE+ +G+ E EE + +EK
Sbjct: 645 EEKMWEQEEKMREQEEKMREQEEKMQGQEE-KMREQEEKMQGQEEKMREQEEKMRGQEEK 703
Query: 574 DSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKL-RAP 632
G+ +K +E + + ++ R KEER D+ K ++++R EH + + L +
Sbjct: 704 MWGQE-EKMWGQE---EKMWGQEEMREKEERIRDQ-KEKMQERLPEHEERCSEPCLPPSK 758
Query: 633 IICVLGH 639
++C + H
Sbjct: 759 VLCNMSH 765
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 120 bits (301), Expect = 8e-27
Identities = 163/681 (23%), Positives = 280/681 (41%), Gaps = 106/681 (15%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK-- 60
+KQ+ ++ S + +D D E+ K+Q + G K K+Q F ++ K
Sbjct: 843 RKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVA 902
Query: 61 ELEELSLE-----AQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
E +E S + ++ +A K + ++ + TS+D KK+ +KG +EE
Sbjct: 903 ETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKG---------TEE 953
Query: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA------KGKAQKSNKKWDGSEEDED 169
+ KK K + + S SD + KLP++ KG Q N DG E
Sbjct: 954 KKKPSDFKKKVIKMEQQYESSSDGTE---KLPEREEICHFPKGIKQIKNGTTDG----EK 1006
Query: 170 NSKKIKERS------------RINSSGESGDESDEFLQSRKG----QKKNQK--NKPGPN 211
SKKI++++ + G+S D S++ +S+ G +KK K K
Sbjct: 1007 KSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED-KKSKNGAYGREKKRCKLLGKSSRK 1065
Query: 212 IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK--DQSKQ 269
+ + D + +K ++K+ + + R E+ L + +E+++G D +
Sbjct: 1066 RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELR--ERRNLSSKRNTKEIQSGSSSSDAEES 1123
Query: 270 KESQRKFEEETVKSKVTV-------DTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKK 322
E +K ++ T K V ++ ++A+ +++ D E D + +
Sbjct: 1124 SEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSS 1183
Query: 323 GEKEEKEKEKKKGPSKAT---VKAMQEALAK---LKEEEERQKREEEERIKR---LEELE 373
E++ K + S T + EAL+K + +++ + E RI + LEE++
Sbjct: 1184 DEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIK 1243
Query: 374 AKRKEEE------RLEQEKRERKKQKEK-----ERKERLKKEGKLLTKSQREARARAEAT 422
A +E E+ K+ KQ E+ E K ++ E ++ ++ R R
Sbjct: 1244 ANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLL 1303
Query: 423 L-KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVP 481
KL + G K + PK+ + + R+K+ E E S+ E + EV E
Sbjct: 1304 RHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS--EDSEDSDFQESGVSEEVSESEDE 1361
Query: 482 EKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEE 541
++ T + E EE+ +E E K N EEEEEE+EEE
Sbjct: 1362 QRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSEN-------KSNSEEEEEEKEEE 1414
Query: 542 EEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTK 601
EE+EE EEEEEE DE D D K GK KK K + D + K
Sbjct: 1415 EEEEEEEEEEEE---------DEND----DSKSPGKG-RKKIRKILKDDKLRTETQNALK 1460
Query: 602 EERAYDKAKRRIEKRRLEHSK 622
EE ++ ++RI +R E K
Sbjct: 1461 EE---EERRKRIAEREREREK 1478
Score = 111 bits (278), Expect = 4e-24
Identities = 161/751 (21%), Positives = 295/751 (39%), Gaps = 155/751 (20%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
KK K S DS D+ +P K K+ E Q+ D D++L L
Sbjct: 659 KKDKRNSSDSAIDN------------------PKPNKLPKSKQSETVDQNSDSDEMLAIL 700
Query: 63 EELSLEAQGIKADRETVAVKPTENNEEEF-TSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
+E+S + +D + + + T K KG++ +K S +D + + K +
Sbjct: 701 KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA 760
Query: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAK-----GKAQKSNKK------WDGSEEDE-- 168
KS +K K + S S + D ++L K+ K G A+ + K+ +D SE+++
Sbjct: 761 KSSIISKKKRQTQSESSNYD--SELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS 818
Query: 169 --------------------DNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK--- 205
D++++ +ER +S+ + D+ ++ R K Q+
Sbjct: 819 KKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASA 878
Query: 206 NKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK--------RDEEKAKLRKLKEKE 257
+ G + SG E S +++ VA+ K + K + K D + L+K + E
Sbjct: 879 STDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDE 938
Query: 258 ELETGKKDQSKQKESQRK---FEEETVKSKVTVD-----TGVIPASEEKAETPTAAEDDN 309
E KK K E ++K F+++ +K + + T +P EE P +
Sbjct: 939 TSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIK 998
Query: 310 EGDKKKKDKKKKKGEKEEKEKEKKKG-PSKATVKAMQEALAKLKEEEERQKREEEERIKR 368
G + K KK +K K+K++ K+T K ++ K+ + E++R K
Sbjct: 999 NGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKL 1058
Query: 369 LEELEAKRKEEERLEQEKRERKKQ---------KEKERKERLKKEGKLLTKSQREARARA 419
L + KR++ + EK K+ K E +ER K TK + + +
Sbjct: 1059 LGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSS 1118
Query: 420 EATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ- 478
+A + + + S KK I ++KKR + + K+ + + +E +Q
Sbjct: 1119 DA--EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQN 1176
Query: 479 ----GVPEKEETPP--------------------------PVEPEEEEDTED-------- 500
G ++++ P PV ++++D D
Sbjct: 1177 SIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKK 1236
Query: 501 -------AGLDDWEAMASDEETEKVEGNK-VHIEVKENP-EEEEEEEEEEEEDEESEEEE 551
A L E +SD+E E EG K + +ENP +EE + + E D +SEE +
Sbjct: 1237 MLLEEIKANLSSDEDGSSDDEPE--EGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESK 1294
Query: 552 EEEGE----------SEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEY-------- 593
+ S+G G+E+ K + K+ +K S E S DS++
Sbjct: 1295 KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEE 1354
Query: 594 --DSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
+S+D++ R+ KA+ +R + K
Sbjct: 1355 VSESEDEQRPRTRSAKKAELEENQRSYKQKK 1385
Score = 94.4 bits (233), Expect = 6e-19
Identities = 130/586 (22%), Positives = 236/586 (40%), Gaps = 63/586 (10%)
Query: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
+K++S+++++DD +G K+ K K K +++ + D + L E EE
Sbjct: 932 KKDQSDETSEDDKKQSK-----KGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREE 986
Query: 65 LSLEAQGIKADRE-TVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
+ +GIK + T + + TSK K + +K + + + EDK SK+
Sbjct: 987 ICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN 1046
Query: 124 KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
+ K K + +K + K DG + K+I+ R R N
Sbjct: 1047 GAYGREKKRCKLLGKSS---RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN-- 1101
Query: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAE--KKERERK 241
L S++ K+ Q + E +ED+ K +T ++KKA K+++
Sbjct: 1102 ----------LSSKRNTKEIQSGSSSSDAEESSEDNKKK-KQRTSSKKKAVIVKEKKRNS 1150
Query: 242 KRDEEKAKLRKLKEKEELETGKKDQSKQKES---QRKFEEETVKSKVTVDTGVIPASEEK 298
R K K + + DQ+ E ++K + T ++ TG +S ++
Sbjct: 1151 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDE 1210
Query: 299 AETP----TAAEDDNEGDKKKKDKKK-------------KKGEKEEKEKEKKKGPSKATV 341
A + T +DD++ D + + KK + G +++ +E KK K
Sbjct: 1211 ALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNE 1270
Query: 342 KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERL 401
+ + AK + E EE + R + K + E E KK K KE KE
Sbjct: 1271 ENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS-DGESGEEKKTKPKEHKEVK 1329
Query: 402 KKEGKLLTKSQREARARAEATL--KLLQAQGVEVPSKDSLPK------KRPIYEDKKRKK 453
+ + ++ E E+ + ++ +++ + P S K +R + KKR++
Sbjct: 1330 GRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRR 1389
Query: 454 IPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDE 513
I Q +S ++S + E E+ E+EE E EEEE+ ED D +
Sbjct: 1390 IKVQEDSSSENKS----NSEEEEEEKEEEEEE-----EEEEEEEEEDENDDSKSPGKGRK 1440
Query: 514 ETEKV-EGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESE 558
+ K+ + +K+ E + +EEEE + E E E+ E E E
Sbjct: 1441 KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIE 1486
Score = 87.0 bits (214), Expect = 1e-16
Identities = 133/687 (19%), Positives = 267/687 (38%), Gaps = 87/687 (12%)
Query: 3 KKQKNKSEDS-TKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
KK +KSE ++ +D + + + +EQ KS G + K+ +++ + +
Sbjct: 416 KKDISKSEAKLSRKQVDSEHMHQNVP----TEEQRTNKSTGGEHKKSDRKEEPQYEPANT 471
Query: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSE-ELEDKD 120
E+L ++ + + + E E +S D + G G +Q + + + + KD
Sbjct: 472 SEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKD 531
Query: 121 S----KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKE 176
+ KSK TAK E+Y KL + + +D+D K
Sbjct: 532 NRGGIKSKTTAKVTKELYV---------KLTPVSLSNSPIKGADCQEVPQDKDGYKSCGL 582
Query: 177 RSRINSSGESGDESD---------EFLQSRKGQKKNQKNKPGP-------NIESGNEDDD 220
++ G + SD L +++ + K P N + N D++
Sbjct: 583 NPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEE 642
Query: 221 ASFKIKTVAQKKAEKKERERKKRDE---EKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
+ +K + ++++++ + + K KL + ++ ET ++ + E
Sbjct: 643 CNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKE 702
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPS 337
+ + DT + +E T + + K K K+K+K + + KKG S
Sbjct: 703 VSRMSHSSSSDTDI---NEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS 759
Query: 338 KATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER 397
A + + + + E E E+ IK + ++ A R ++R+ K + EK
Sbjct: 760 -AKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS 818
Query: 398 KERLKKEG--KLLT-----------KSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444
K+ + +G L T K +RE + AE T + + +D LPKK+
Sbjct: 819 KKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGT---VDKDTTIMELRDRLPKKQ- 874
Query: 445 IYEDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
+ +L KE S S+E+ E E+ K +T V+ + E
Sbjct: 875 --QASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLK 932
Query: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEE--------EEEEEEEEEEDEESEEEEE--- 552
D S+++ ++ +K E K+ P + E++ E + E+ E EE
Sbjct: 933 KDQSDETSEDDKKQ---SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH 989
Query: 553 -----EEGESEGSEGDEEDEKVSDEKDSGK-TLDKKPSKEMSSDSEYDSDDDRTKEERAY 606
++ ++ ++G+++ +K+ D+ K L K DS +D+ + AY
Sbjct: 990 FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAY 1049
Query: 607 DKAKRRIE-----KRRLEHSKNVNTEK 628
+ K+R + R+ + + +TEK
Sbjct: 1050 GREKKRCKLLGKSSRKRQDCSSSDTEK 1076
Score = 86.3 bits (212), Expect = 2e-16
Identities = 94/469 (20%), Positives = 194/469 (41%), Gaps = 42/469 (8%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
K+Q S D+ K + D + + + +E + K+ ++ + D +
Sbjct: 1065 KRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESS 1124
Query: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
E+ + Q + ++ V VK + N ++K K+ +D+D + + S
Sbjct: 1125 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1184
Query: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN---SKKIKERSR 179
+K KP E S +A K+ D + D +N K + E +
Sbjct: 1185 EQKI-KPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIK 1243
Query: 180 IN-SSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAE--KK 236
N SS E G DE + +K K + PG D++A ++ + + +E KK
Sbjct: 1244 ANLSSDEDGSSDDEPEEGKKRTGKQNEENPG--------DEEAKNQVNSESDSDSEESKK 1295
Query: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK-ESQRKFEEETVKSKVTVDTGVIPAS 295
R R + K + + EE +T K+ + K ++RK E + ++GV S
Sbjct: 1296 PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGV---S 1352
Query: 296 EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK--- 352
EE +E+ E +++ + + KK E EE ++ K+ + +K +++ ++ K
Sbjct: 1353 EEVSES--------EDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1404
Query: 353 --------EEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKE 404
EEEE ++ EEEE ++ ++ K +++ + ++ K + E + + ++E
Sbjct: 1405 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1464
Query: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK 453
+ + R + +++ A P+K + K + ED++ K+
Sbjct: 1465 RRKRIAEREREREKLREVIEIEDAS----PTKCPITTKLVLDEDEETKE 1509
Score = 85.1 bits (209), Expect = 4e-16
Identities = 133/641 (20%), Positives = 261/641 (40%), Gaps = 79/641 (12%)
Query: 30 GAAKEQEPQKSKGKK------KKEK---KKQDFDEDDILKELEELSLEAQGIKAD---RE 77
GA ++ PQ G K K EK +++ D + +++ L LE ++ +
Sbjct: 564 GADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKT 623
Query: 78 TVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGS 137
T +PTE N S ++ + K K++ S + KD ++ + +
Sbjct: 624 TPLRRPTETNPVTSNSDEECNETVKEKQKL-----SVPVRKKDKRNSSDS---------A 669
Query: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197
D+ NKLPK K ++ D + + ++ +KE SR++ S S + +E
Sbjct: 670 IDNPKPNKLPKS------KQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEI---- 719
Query: 198 KGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAK-LRKLKEK 256
N K ++G +D K K + + + KK K+ + K K +
Sbjct: 720 ---HTNHKTLYDLKTQAGKDD-----KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ 771
Query: 257 EELETGKKDQSKQKE--SQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKK 314
+ E+ D +KE S K K +T +SE++ + DN+G K
Sbjct: 772 TQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGM--DNQGHKN 829
Query: 315 KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEA 374
K ++ + E+++E++ S + +L++ + K++ +++L
Sbjct: 830 LKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPK-KQQASASTDGVDKLSG 888
Query: 375 KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV--- 431
K + LE K K+K K K + K K Q AE LK Q+
Sbjct: 889 KEQSFTSLEVRKVAETKEKSKHLKTKTCK------KVQDGLSDIAEKFLKKDQSDETSED 942
Query: 432 --EVPSKDSLPKKRPIYEDKKRKKIPQQLES-----KEVSESMELC---AAVEVMEQGVP 481
+ K + KK+P KK K+ QQ ES +++ E E+C ++ ++ G
Sbjct: 943 DKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTT 1002
Query: 482 EKEETPPPV----EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE 537
+ E+ + +++E ++ A + + D +K N + K+ + +
Sbjct: 1003 DGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRC-KLLGK 1061
Query: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM-----SSDSE 592
+ +D S + E+ + +G ++ K + ++ K+ +KE+ SSD+E
Sbjct: 1062 SSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE 1121
Query: 593 YDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPI 633
S+D++ K++R K K I K + +S +T++ +A I
Sbjct: 1122 ESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADI 1162
Score = 33.9 bits (76), Expect = 0.97
Identities = 29/112 (25%), Positives = 43/112 (38%), Gaps = 13/112 (11%)
Query: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKW 161
K K FD++ +E DS S S DD+ K KK K + S+
Sbjct: 1858 KENKGYFDEDSMDEFIASDSDET----------SMSLSSDDYTKKKKKGKKGKKDSSSSG 1907
Query: 162 DGSEEDEDNSKKIKERSRINSSG---ESGDESDEFLQSRKGQKKNQKNKPGP 210
GS+ D + K RSR G E+G+ L+ + + + N P
Sbjct: 1908 SGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSP 1959
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 120 bits (301), Expect = 8e-27
Identities = 163/681 (23%), Positives = 280/681 (41%), Gaps = 106/681 (15%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK-- 60
+KQ+ ++ S + +D D E+ K+Q + G K K+Q F ++ K
Sbjct: 881 RKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVA 940
Query: 61 ELEELSLE-----AQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
E +E S + ++ +A K + ++ + TS+D KK+ +KG +EE
Sbjct: 941 ETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKG---------TEE 991
Query: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA------KGKAQKSNKKWDGSEEDED 169
+ KK K + + S SD + KLP++ KG Q N DG E
Sbjct: 992 KKKPSDFKKKVIKMEQQYESSSDGTE---KLPEREEICHFPKGIKQIKNGTTDG----EK 1044
Query: 170 NSKKIKERS------------RINSSGESGDESDEFLQSRKG----QKKNQK--NKPGPN 211
SKKI++++ + G+S D S++ +S+ G +KK K K
Sbjct: 1045 KSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSED-KKSKNGAYGREKKRCKLLGKSSRK 1103
Query: 212 IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK--DQSKQ 269
+ + D + +K ++K+ + + R E+ L + +E+++G D +
Sbjct: 1104 RQDCSSSDTEKYSMKEDGCNSSDKRLKRIELR--ERRNLSSKRNTKEIQSGSSSSDAEES 1161
Query: 270 KESQRKFEEETVKSKVTV-------DTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKK 322
E +K ++ T K V ++ ++A+ +++ D E D + +
Sbjct: 1162 SEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSS 1221
Query: 323 GEKEEKEKEKKKGPSKAT---VKAMQEALAK---LKEEEERQKREEEERIKR---LEELE 373
E++ K + S T + EAL+K + +++ + E RI + LEE++
Sbjct: 1222 DEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIK 1281
Query: 374 AKRKEEE------RLEQEKRERKKQKEK-----ERKERLKKEGKLLTKSQREARARAEAT 422
A +E E+ K+ KQ E+ E K ++ E ++ ++ R R
Sbjct: 1282 ANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLL 1341
Query: 423 L-KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVP 481
KL + G K + PK+ + + R+K+ E E S+ E + EV E
Sbjct: 1342 RHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS--EDSEDSDFQESGVSEEVSESEDE 1399
Query: 482 EKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEE 541
++ T + E EE+ +E E K N EEEEEE+EEE
Sbjct: 1400 QRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSEN-------KSNSEEEEEEKEEE 1452
Query: 542 EEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTK 601
EE+EE EEEEEE DE D D K GK KK K + D + K
Sbjct: 1453 EEEEEEEEEEEE---------DEND----DSKSPGKG-RKKIRKILKDDKLRTETQNALK 1498
Query: 602 EERAYDKAKRRIEKRRLEHSK 622
EE ++ ++RI +R E K
Sbjct: 1499 EE---EERRKRIAEREREREK 1516
Score = 111 bits (278), Expect = 4e-24
Identities = 161/751 (21%), Positives = 295/751 (39%), Gaps = 155/751 (20%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
KK K S DS D+ +P K K+ E Q+ D D++L L
Sbjct: 697 KKDKRNSSDSAIDN------------------PKPNKLPKSKQSETVDQNSDSDEMLAIL 738
Query: 63 EELSLEAQGIKADRETVAVKPTENNEEEF-TSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
+E+S + +D + + + T K KG++ +K S +D + + K +
Sbjct: 739 KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA 798
Query: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAK-----GKAQKSNKK------WDGSEEDE-- 168
KS +K K + S S + D ++L K+ K G A+ + K+ +D SE+++
Sbjct: 799 KSSIISKKKRQTQSESSNYD--SELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS 856
Query: 169 --------------------DNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK--- 205
D++++ +ER +S+ + D+ ++ R K Q+
Sbjct: 857 KKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASA 916
Query: 206 NKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK--------RDEEKAKLRKLKEKE 257
+ G + SG E S +++ VA+ K + K + K D + L+K + E
Sbjct: 917 STDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDE 976
Query: 258 ELETGKKDQSKQKESQRK---FEEETVKSKVTVD-----TGVIPASEEKAETPTAAEDDN 309
E KK K E ++K F+++ +K + + T +P EE P +
Sbjct: 977 TSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIK 1036
Query: 310 EGDKKKKDKKKKKGEKEEKEKEKKKG-PSKATVKAMQEALAKLKEEEERQKREEEERIKR 368
G + K KK +K K+K++ K+T K ++ K+ + E++R K
Sbjct: 1037 NGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKL 1096
Query: 369 LEELEAKRKEEERLEQEKRERKKQ---------KEKERKERLKKEGKLLTKSQREARARA 419
L + KR++ + EK K+ K E +ER K TK + + +
Sbjct: 1097 LGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSS 1156
Query: 420 EATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ- 478
+A + + + S KK I ++KKR + + K+ + + +E +Q
Sbjct: 1157 DA--EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQN 1214
Query: 479 ----GVPEKEETPP--------------------------PVEPEEEEDTED-------- 500
G ++++ P PV ++++D D
Sbjct: 1215 SIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKK 1274
Query: 501 -------AGLDDWEAMASDEETEKVEGNK-VHIEVKENP-EEEEEEEEEEEEDEESEEEE 551
A L E +SD+E E EG K + +ENP +EE + + E D +SEE +
Sbjct: 1275 MLLEEIKANLSSDEDGSSDDEPE--EGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESK 1332
Query: 552 EEEGE----------SEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEY-------- 593
+ S+G G+E+ K + K+ +K S E S DS++
Sbjct: 1333 KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEE 1392
Query: 594 --DSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
+S+D++ R+ KA+ +R + K
Sbjct: 1393 VSESEDEQRPRTRSAKKAELEENQRSYKQKK 1423
Score = 94.4 bits (233), Expect = 6e-19
Identities = 130/586 (22%), Positives = 236/586 (40%), Gaps = 63/586 (10%)
Query: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
+K++S+++++DD +G K+ K K K +++ + D + L E EE
Sbjct: 970 KKDQSDETSEDDKKQSK-----KGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREE 1024
Query: 65 LSLEAQGIKADRE-TVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
+ +GIK + T + + TSK K + +K + + + EDK SK+
Sbjct: 1025 ICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN 1084
Query: 124 KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
+ K K + +K + K DG + K+I+ R R N
Sbjct: 1085 GAYGREKKRCKLLGKSS---RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRN-- 1139
Query: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAE--KKERERK 241
L S++ K+ Q + E +ED+ K +T ++KKA K+++
Sbjct: 1140 ----------LSSKRNTKEIQSGSSSSDAEESSEDNKKK-KQRTSSKKKAVIVKEKKRNS 1188
Query: 242 KRDEEKAKLRKLKEKEELETGKKDQSKQKES---QRKFEEETVKSKVTVDTGVIPASEEK 298
R K K + + DQ+ E ++K + T ++ TG +S ++
Sbjct: 1189 LRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDE 1248
Query: 299 AETP----TAAEDDNEGDKKKKDKKK-------------KKGEKEEKEKEKKKGPSKATV 341
A + T +DD++ D + + KK + G +++ +E KK K
Sbjct: 1249 ALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNE 1308
Query: 342 KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERL 401
+ + AK + E EE + R + K + E E KK K KE KE
Sbjct: 1309 ENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS-DGESGEEKKTKPKEHKEVK 1367
Query: 402 KKEGKLLTKSQREARARAEATL--KLLQAQGVEVPSKDSLPK------KRPIYEDKKRKK 453
+ + ++ E E+ + ++ +++ + P S K +R + KKR++
Sbjct: 1368 GRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRR 1427
Query: 454 IPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDE 513
I Q +S ++S + E E+ E+EE E EEEE+ ED D +
Sbjct: 1428 IKVQEDSSSENKS----NSEEEEEEKEEEEEE-----EEEEEEEEEDENDDSKSPGKGRK 1478
Query: 514 ETEKV-EGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESE 558
+ K+ + +K+ E + +EEEE + E E E+ E E E
Sbjct: 1479 KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIE 1524
Score = 87.0 bits (214), Expect = 1e-16
Identities = 133/687 (19%), Positives = 267/687 (38%), Gaps = 87/687 (12%)
Query: 3 KKQKNKSEDS-TKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
KK +KSE ++ +D + + + +EQ KS G + K+ +++ + +
Sbjct: 454 KKDISKSEAKLSRKQVDSEHMHQNVP----TEEQRTNKSTGGEHKKSDRKEEPQYEPANT 509
Query: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSE-ELEDKD 120
E+L ++ + + + E E +S D + G G +Q + + + + KD
Sbjct: 510 SEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKD 569
Query: 121 S----KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKE 176
+ KSK TAK E+Y KL + + +D+D K
Sbjct: 570 NRGGIKSKTTAKVTKELYV---------KLTPVSLSNSPIKGADCQEVPQDKDGYKSCGL 620
Query: 177 RSRINSSGESGDESD---------EFLQSRKGQKKNQKNKPGP-------NIESGNEDDD 220
++ G + SD L +++ + K P N + N D++
Sbjct: 621 NPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEE 680
Query: 221 ASFKIKTVAQKKAEKKERERKKRDE---EKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
+ +K + ++++++ + + K KL + ++ ET ++ + E
Sbjct: 681 CNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKE 740
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPS 337
+ + DT + +E T + + K K K+K+K + + KKG S
Sbjct: 741 VSRMSHSSSSDTDI---NEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKS 797
Query: 338 KATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER 397
A + + + + E E E+ IK + ++ A R ++R+ K + EK
Sbjct: 798 -AKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS 856
Query: 398 KERLKKEG--KLLT-----------KSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444
K+ + +G L T K +RE + AE T + + +D LPKK+
Sbjct: 857 KKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGT---VDKDTTIMELRDRLPKKQ- 912
Query: 445 IYEDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
+ +L KE S S+E+ E E+ K +T V+ + E
Sbjct: 913 --QASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLK 970
Query: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEE--------EEEEEEEEEEDEESEEEEE--- 552
D S+++ ++ +K E K+ P + E++ E + E+ E EE
Sbjct: 971 KDQSDETSEDDKKQ---SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH 1027
Query: 553 -----EEGESEGSEGDEEDEKVSDEKDSGK-TLDKKPSKEMSSDSEYDSDDDRTKEERAY 606
++ ++ ++G+++ +K+ D+ K L K DS +D+ + AY
Sbjct: 1028 FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAY 1087
Query: 607 DKAKRRIE-----KRRLEHSKNVNTEK 628
+ K+R + R+ + + +TEK
Sbjct: 1088 GREKKRCKLLGKSSRKRQDCSSSDTEK 1114
Score = 86.3 bits (212), Expect = 2e-16
Identities = 94/469 (20%), Positives = 194/469 (41%), Gaps = 42/469 (8%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
K+Q S D+ K + D + + + +E + K+ ++ + D +
Sbjct: 1103 KRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESS 1162
Query: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
E+ + Q + ++ V VK + N ++K K+ +D+D + + S
Sbjct: 1163 EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1222
Query: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN---SKKIKERSR 179
+K KP E S +A K+ D + D +N K + E +
Sbjct: 1223 EQKI-KPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIK 1281
Query: 180 IN-SSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAE--KK 236
N SS E G DE + +K K + PG D++A ++ + + +E KK
Sbjct: 1282 ANLSSDEDGSSDDEPEEGKKRTGKQNEENPG--------DEEAKNQVNSESDSDSEESKK 1333
Query: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK-ESQRKFEEETVKSKVTVDTGVIPAS 295
R R + K + + EE +T K+ + K ++RK E + ++GV S
Sbjct: 1334 PRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGV---S 1390
Query: 296 EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK--- 352
EE +E+ E +++ + + KK E EE ++ K+ + +K +++ ++ K
Sbjct: 1391 EEVSES--------EDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1442
Query: 353 --------EEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKE 404
EEEE ++ EEEE ++ ++ K +++ + ++ K + E + + ++E
Sbjct: 1443 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1502
Query: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK 453
+ + R + +++ A P+K + K + ED++ K+
Sbjct: 1503 RRKRIAEREREREKLREVIEIEDAS----PTKCPITTKLVLDEDEETKE 1547
Score = 85.1 bits (209), Expect = 4e-16
Identities = 133/641 (20%), Positives = 261/641 (40%), Gaps = 79/641 (12%)
Query: 30 GAAKEQEPQKSKGKK------KKEK---KKQDFDEDDILKELEELSLEAQGIKAD---RE 77
GA ++ PQ G K K EK +++ D + +++ L LE ++ +
Sbjct: 602 GADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKT 661
Query: 78 TVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGS 137
T +PTE N S ++ + K K++ S + KD ++ + +
Sbjct: 662 TPLRRPTETNPVTSNSDEECNETVKEKQKL-----SVPVRKKDKRNSSDS---------A 707
Query: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197
D+ NKLPK K ++ D + + ++ +KE SR++ S S + +E
Sbjct: 708 IDNPKPNKLPKS------KQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEI---- 757
Query: 198 KGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAK-LRKLKEK 256
N K ++G +D K K + + + KK K+ + K K +
Sbjct: 758 ---HTNHKTLYDLKTQAGKDD-----KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ 809
Query: 257 EELETGKKDQSKQKE--SQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKK 314
+ E+ D +KE S K K +T +SE++ + DN+G K
Sbjct: 810 TQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGM--DNQGHKN 867
Query: 315 KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEA 374
K ++ + E+++E++ S + +L++ + K++ +++L
Sbjct: 868 LKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPK-KQQASASTDGVDKLSG 926
Query: 375 KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV--- 431
K + LE K K+K K K + K K Q AE LK Q+
Sbjct: 927 KEQSFTSLEVRKVAETKEKSKHLKTKTCK------KVQDGLSDIAEKFLKKDQSDETSED 980
Query: 432 --EVPSKDSLPKKRPIYEDKKRKKIPQQLES-----KEVSESMELC---AAVEVMEQGVP 481
+ K + KK+P KK K+ QQ ES +++ E E+C ++ ++ G
Sbjct: 981 DKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTT 1040
Query: 482 EKEETPPPV----EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE 537
+ E+ + +++E ++ A + + D +K N + K+ + +
Sbjct: 1041 DGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRC-KLLGK 1099
Query: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM-----SSDSE 592
+ +D S + E+ + +G ++ K + ++ K+ +KE+ SSD+E
Sbjct: 1100 SSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE 1159
Query: 593 YDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPI 633
S+D++ K++R K K I K + +S +T++ +A I
Sbjct: 1160 ESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADI 1200
Score = 33.9 bits (76), Expect = 0.97
Identities = 29/112 (25%), Positives = 43/112 (38%), Gaps = 13/112 (11%)
Query: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKW 161
K K FD++ +E DS S S DD+ K KK K + S+
Sbjct: 1896 KENKGYFDEDSMDEFIASDSDET----------SMSLSSDDYTKKKKKGKKGKKDSSSSG 1945
Query: 162 DGSEEDEDNSKKIKERSRINSSG---ESGDESDEFLQSRKGQKKNQKNKPGP 210
GS+ D + K RSR G E+G+ L+ + + + N P
Sbjct: 1946 SGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSP 1997
Score = 33.1 bits (74), Expect = 1.7
Identities = 31/141 (21%), Positives = 58/141 (41%), Gaps = 19/141 (13%)
Query: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEE 552
EE E+T +A ++ T+K+ G+ + ++ EN +EE E+ + S +
Sbjct: 27 EESEETSSP-----PRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKR 81
Query: 553 E--------EGESEGSEGDE--EDEKVSDEKDSGKTLDKKPSKEMSSDSE----YDSDDD 598
+ E + E DE ++ ++ ++ T+ P + E D DD
Sbjct: 82 KPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDF 141
Query: 599 RTKEERAYDKAKRRIEKRRLE 619
+ E R+ K K K+R E
Sbjct: 142 KGPEFRSRSKMKTENLKKRGE 162
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 113 bits (282), Expect = 1e-24
Identities = 144/644 (22%), Positives = 279/644 (43%), Gaps = 81/644 (12%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
KE+E + +GK +EKKK +E+ + + E+LS E + EEE
Sbjct: 1731 KEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLA-------------QEEELL 1777
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNK------- 145
++K+K Q +K ++ ++ + K K E + S ++ NK
Sbjct: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKK 1837
Query: 146 -LPKKAKGKAQKSNKKWDGSE------EDEDNSKK--IKERSRINSSGESGDESDEFLQS 196
L ++ K AQ+ K E E +SKK ++ ++++ + + +E L
Sbjct: 1838 NLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQ 1897
Query: 197 RKGQKKNQKNKPGPNIESGNE-DDDASFKIKTVAQKKA----EKKERERKKR-------- 243
K +K K + + +D + K + +AQ+K EK + KKR
Sbjct: 1898 EKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIA 1957
Query: 244 DEEKA-----------KLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVI 292
EEKA K+R ++ KE L G+ ++ ++ + E+E + K++++ ++
Sbjct: 1958 KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKIL 2017
Query: 293 PASE-----EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSK--ATVKAMQ 345
+ E++E + G + ++K + K +K++ SK A + +
Sbjct: 2018 LHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKIL 2077
Query: 346 EALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEG 405
+AL KL +E + +EE + K L K + +EQ K + K+ E++ L K+
Sbjct: 2078 KALQKLTRDERKLTQEEIKMTKMKRALFVKERRLS-IEQSKLDIKEWDFSEKRSELTKDE 2136
Query: 406 KLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSE 465
K L + QR+ + + + + E SK + I +D++ I E +EV
Sbjct: 2137 KKLARKQRKLANKMRRMINK-EEKMTEEESKLARKHSEVILDDEEEGGI----EEEEV-- 2189
Query: 466 SMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHI 525
+ +++ +++E +P+E+ ++ +D+ E+ + +E++E +
Sbjct: 2190 -------IPFLKRRWRKRKEAKRGDKPKEKFSSQ---VDEVES--EEHFSEEMESLLDEL 2237
Query: 526 EVKEN-PEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPS 584
E +E+ EEEEE EEEEE EE E EEEE E EG+E+ + +E+ K +KK
Sbjct: 2238 EKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKE 2297
Query: 585 KEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
+ + ++ ++ EE + E+ + V+ EK
Sbjct: 2298 EVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK 2341
Score = 95.1 bits (235), Expect = 4e-19
Identities = 145/662 (21%), Positives = 288/662 (43%), Gaps = 92/662 (13%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDIL--KELEELSLEAQGIKADRETVAVKPTENNEEE 90
KE P++ + +KK + +E ++ K + + LE + +E EE+
Sbjct: 1340 KEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEI------SKKEEK 1393
Query: 91 FTSKDKKKKGQKG-----------KKQSFDDND-SEELEDKDSKSKKTAKP--KVEMYSG 136
T + K+G+K ++ + ++ D SEE+E+ + +K K K+ M
Sbjct: 1394 KTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIER 1453
Query: 137 SDDDDDFNKLP---KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEF 193
+ D+ K K+ G+ +KS K W ++E + ++E +++ +GE +E
Sbjct: 1454 TPSWQDWKKAWDEWKQVHGETRKSWKAW----KEEWEKRLLQEEEKLHQAGEKLSPEEEM 1509
Query: 194 LQSRKGQKKNQKNKPGPNIESGNED-----DDASFKIKTVAQKKAEKKERE-----RKKR 243
LQ K K + + N+ S D+ ++ ++ E+KE++ R +
Sbjct: 1510 LQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQ 1569
Query: 244 DEEK--------AKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKS----KVTVDTGV 291
+E K A+ K + +EE + ++++ +E ++ +EE + K+T D
Sbjct: 1570 EEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDRE 1629
Query: 292 IPASEEK--------AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK--KKGPSKATV 341
+ +E K A+ + E +K+ K KK EK +E+EK KKG A V
Sbjct: 1630 MAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEV 1689
Query: 342 K-AMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE----EERLEQEK----RERKKQ 392
K + + + +L + E+ +E+E + LEELE +E EE L QE+ E+KK
Sbjct: 1690 KNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKL 1749
Query: 393 KEKE-----RKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447
E+E ++E+L +E TK +E + KL Q + ++ L +KR
Sbjct: 1750 AEEEEALAWQREKLSEEE---TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLI 1806
Query: 448 DKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507
+KK K ++ E + + ++ + ++++ + + + E+ +
Sbjct: 1807 EKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKER 1866
Query: 508 AMASDEETEKVEG-----NKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG 562
S ++ +V+ NK+ +V+E +E+E +++E E++ + E +
Sbjct: 1867 LTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLA-- 1924
Query: 563 DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRI--EKRRLEH 620
++ EK++ EK L+K + + D KEE+A + +R+ EK RL
Sbjct: 1925 -KKQEKLAQEK-MKLALEK---AMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVE 1979
Query: 621 SK 622
K
Sbjct: 1980 GK 1981
Score = 83.2 bits (204), Expect = 1e-15
Identities = 95/429 (22%), Positives = 195/429 (45%), Gaps = 65/429 (15%)
Query: 30 GAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEE 89
G K + + KK++ K+ + ILK L++L+ + + + EE
Sbjct: 2048 GQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKL-------------TQEE 2094
Query: 90 EFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKK 149
+K K+ K ++ S + + + +++ D K++ K D KL +K
Sbjct: 2095 IKMTKMKRALFVKERRLSIEQSKLD-IKEWDFSEKRSELTK-----------DEKKLARK 2142
Query: 150 AKGKAQKSNKKWDGSEE-DEDNSKKIKERSRI--NSSGESGDESDE---FLQSRKGQKKN 203
+ A K + + E+ E+ SK ++ S + + E G E +E FL+ R ++K
Sbjct: 2143 QRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKE 2202
Query: 204 QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGK 263
K P + ++ D+ E E +E ++ L +L+++E L +
Sbjct: 2203 AKRGDKPKEKFSSQVDEV---------------ESEEHFSEEMESLLDELEKQESLSS-- 2245
Query: 264 KDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG 323
++ +++E + + EEE V+ + EE+ E E E ++++K KKKK+
Sbjct: 2246 -EEEEEREEEEEREEEEVREE----------EEERKEEEEGEEKQVEKEEEEKKKKKKEK 2294
Query: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLE 383
+KEE +++++ K + + +E + EEEE + EE + R +E+ K+E++ +
Sbjct: 2295 KKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEI---LKKEKQFK 2351
Query: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKD--SLPK 441
+++ RK + +ER + + G K + ++ LK L + +E+ K +P+
Sbjct: 2352 LQEQRRKSLRGRERVLSILR-GVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPE 2410
Query: 442 KRPIYEDKK 450
K+ +EDKK
Sbjct: 2411 KQISWEDKK 2419
Score = 75.9 bits (185), Expect = 2e-13
Identities = 104/535 (19%), Positives = 217/535 (40%), Gaps = 60/535 (11%)
Query: 22 LAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAV 81
+ A++E +++ K K K + +KK ED + K+ E+L+ E + ++ V
Sbjct: 1887 ILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQG 1946
Query: 82 KPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDD 141
K E + K++K + + + +E K++ SK + +
Sbjct: 1947 KKRLRGELDIA---KEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQ 2003
Query: 142 DFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIK----ERSRINSSGESGDESDEFLQSR 197
+ + + K + EE E K++ +R + + S + ++ R
Sbjct: 2004 ELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKR 2063
Query: 198 KGQKKN--QKNKPGPNIESGNEDDD--ASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253
+ K + NK ++ D+ +IK K+A + R ++ K +++
Sbjct: 2064 ESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEW 2123
Query: 254 KEKEELETGKKDQSKQKESQRKF---------------EEET----VKSKVTVDTGVIPA 294
E+ KD+ K QRK EEE+ S+V +D
Sbjct: 2124 DFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGG 2183
Query: 295 SEEKAETP------TAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348
EE+ P ++ GDK K+ + E E +E ++ S QE+L
Sbjct: 2184 IEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESL 2243
Query: 349 AKLKEEEERQKREEEERIKRLEELEAKRK---EEERLEQEKRERKKQKEKERKERLKKEG 405
+ +EEE ++ E EE R EE E K + EE+++E+E+ E+KK+K++++KE ++++
Sbjct: 2244 SSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKE 2303
Query: 406 KLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQL------- 458
++ + + +L + + ++ + +++ I + +K+ K+ +Q
Sbjct: 2304 EVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGR 2363
Query: 459 -------------ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTED 500
+ + + + ++M + KE+TP PV PE++ ED
Sbjct: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPV-PEKQISWED 2417
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/112 (21%), Positives = 65/112 (58%), Gaps = 7/112 (6%)
Query: 3 KKQKNKSEDSTKDDI--DLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
++++ + E+ ++++ + + E EG E+E ++ K KKK++KK++ +++++ +
Sbjct: 2248 EEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFE 2307
Query: 61 ELEELSLEAQ-----GIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQS 107
E EE+ E + + + E+ +++ + E+E K+K+ K Q+ +++S
Sbjct: 2308 EKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKS 2359
Score = 41.6 bits (96), Expect = 0.005
Identities = 73/385 (18%), Positives = 156/385 (40%), Gaps = 57/385 (14%)
Query: 284 KVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKK--------- 334
K ++ + E A P+ + + KK +K +G K+ KE++ K+
Sbjct: 1060 KSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLE 1119
Query: 335 ---GPSKATVKAMQEA-----------LAKLKEEEERQKREEEE-----RIKRLEELEAK 375
G A ++ M+EA + KL ++ + Q+++ + +KRL+++ K
Sbjct: 1120 DESGTEAAPIE-MEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDK 1178
Query: 376 RKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKL-LQAQGVE-V 433
R ++ ++ K++ KK+ KE K++ + T K+ +Q +G +
Sbjct: 1179 RDKKATAQKLKKKHKKK---------GKEAKVINEETTPPVMEQPVTKKVKIQGRGASGI 1229
Query: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA-----AVEVMEQGVPEKE---E 485
+ S + D + + ++ + S L A A E++ P E E
Sbjct: 1230 SGRRSTAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQE 1289
Query: 486 TPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEE---EEEEEEEE 542
P ++ E + ED DW+ + +++ ++ + ++ + +E +E E
Sbjct: 1290 ICPLLKKESKVLLEDL---DWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPRE 1346
Query: 543 EDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTK- 601
E++ ++ + G E ++ +KV + T+ K+ SK+ + S K
Sbjct: 1347 EEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKA 1406
Query: 602 --EERAYDKAKRRIEKRRLEHSKNV 624
+ER K KR + K + S+ V
Sbjct: 1407 VQKERKVGKIKREMTKEERDMSEEV 1431
Score = 40.4 bits (93), Expect = 0.010
Identities = 37/181 (20%), Positives = 83/181 (45%), Gaps = 18/181 (9%)
Query: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
G K K K + + + E+E E++ S ++++ +++++ +E+++ +E
Sbjct: 2206 GDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREE 2265
Query: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
EE E +G + K E EEE KKKK ++ KK+ + + E +
Sbjct: 2266 EEERKEEEEGEE--------KQVEKEEEE-----KKKKKKEKKKEEVQEKE----EVFEE 2308
Query: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
K + ++ + E S +++++ L ++ + ++ KK + E K ++ R R+
Sbjct: 2309 KEEIMSEEETESLSDEEEEEESCSLEEEV-DREKEILKKEKQFKLQEQRRKSLRGRERVL 2367
Query: 182 S 182
S
Sbjct: 2368 S 2368
Score = 31.2 bits (69), Expect = 6.3
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 9/82 (10%)
Query: 1118 QVKQGTPMCVPSKNFV-DIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHF 1176
++K+ TP+ VP K + T +EI K + K +EV K EPIP P + G
Sbjct: 2399 EMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYEPIP---PHVLGTVL 2455
Query: 1177 E--ATDI---LVSKISRQSIDA 1193
E A D+ +S I R++++A
Sbjct: 2456 ESQAQDLKTPFMSHILRRTVEA 2477
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 110 bits (275), Expect = 8e-24
Identities = 103/508 (20%), Positives = 219/508 (43%), Gaps = 72/508 (14%)
Query: 101 QKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKK 160
++G Q+ D D ++ E K ++ + K + +D K+ + + + ++K
Sbjct: 39 RRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDR--------KRERRREKDRHRK 90
Query: 161 WDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDD 220
D E + + +K +ER + D E ++R+ +++ + + G D
Sbjct: 91 RDRHRERQRDREKERERQ----TDRERDRQREKERNRQKERERETEREGERGRDRQTDGQ 146
Query: 221 ASFKIKTVAQKKAEKK-ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE 279
+ + A+K+ E++ +RER+++ E + + +EK E ++++ +Q+E + K E+
Sbjct: 147 RERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE--RRERERQREKENKTEDR 204
Query: 280 TVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKK-DKKKKKGEKEEKEKEKKKGPSK 338
SE E E + E ++K++ D+++ + K E+E+EK+ +
Sbjct: 205 H--------------SERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERER 250
Query: 339 ATVKAMQEALAKLKEEEERQKRE--EEERIKRLEELEAKRKEEERLEQEKRERKKQKEKE 396
A+ + + + +E + + R+ ++ER ++ + +R E +R + KRER++++E+E
Sbjct: 251 ASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERE 310
Query: 397 RKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQ 456
R+ K+E + + +RE + E + R ++KRK+
Sbjct: 311 RERNRKRERERERERERERQRETE--------------------RDREKERERKRKR--- 347
Query: 457 QLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETE 516
E+ E Q E+E E E D + A + E D + +
Sbjct: 348 ---QTEMDRERNRQTGREGRRQAERERER-------ERERDRQSAR--EREERERDRDRD 395
Query: 517 KVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSG 576
+ + + E + + E E++ E E+D ESE E E E +G E D + ++ +G
Sbjct: 396 RQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAG 455
Query: 577 K-----TLDKKPSKEMSSDSEYDSDDDR 599
+ TL P + SD +R
Sbjct: 456 RQRKRSTLYVNPPPRTARSGVVQSDPNR 483
Score = 100 bits (250), Expect = 6e-21
Identities = 90/447 (20%), Positives = 192/447 (42%), Gaps = 29/447 (6%)
Query: 192 EFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER---KKRDEEKA 248
+F + R G +++ + + + DD + +++ EK++ ER +KR+ +
Sbjct: 25 DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 249 KLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD 308
K R K E ++D+ K++E Q E + + K E + E +
Sbjct: 85 KDRHRKRDRHRER-QRDREKERERQTDRERDRQREK-----------ERNRQKERERETE 132
Query: 309 NEGDK---KKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE-RQKREEEE 364
EG++ ++ D ++++ + + EKE+++ + + + K +E E+ RQ+R E E
Sbjct: 133 REGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERE 192
Query: 365 RIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424
R +R +E + + + ER + +RER+ + E ERK + +E K++RE +AE +
Sbjct: 193 R-QREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAER--E 249
Query: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE 484
+ E + + R D+++K+ +Q + K + E E + E+E
Sbjct: 250 RASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT-ERDRETERKRERQRERE 308
Query: 485 ETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEED 544
E E + + D E E+ K E+ + E + +
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE 368
Query: 545 EESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE-- 602
E E E E + +S + E ++ ++D K +++ K+ E + +R K+
Sbjct: 369 RERERERERDRQSAREREERERDR---DRDRQKERERQTEKDRDGQRETEKQREREKDRE 425
Query: 603 -ERAYDKAKRRIEKRRLEHSKNVNTEK 628
ER ++ + R +++ E + T++
Sbjct: 426 SERGRERGREREKQKGRERDRERQTDR 452
Score = 100 bits (249), Expect = 8e-21
Identities = 75/394 (19%), Positives = 186/394 (47%), Gaps = 26/394 (6%)
Query: 34 EQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTS 93
++E + K ++++ +K+Q E D ++ E + + K DR + E E T
Sbjct: 53 DRERNRQKERERRREKRQTERETD--RKRERRREKDRHRKRDRHRERQRDREKERERQTD 110
Query: 94 KDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGK 153
+++ ++ +K + + + E E + + ++T + + + + ++ + +
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170
Query: 154 AQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIE 213
+++ +K E E N ++ +ER R + E S +G+++ ++ + E
Sbjct: 171 TERNRQK---EREREKNRQERRERERQREK----ENKTEDRHSERGRERERERETETETE 223
Query: 214 SGNEDDDASFKIKTVAQKKAEKKERER-KKRDEEKAKLRKLKEKEELETGKKDQSKQKES 272
+ D + + +++ ++ ERER +R+ E+ K R+ + + + ++ + +++++
Sbjct: 224 RKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQT 283
Query: 273 QRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE-----E 327
RK + T + + T E K E E + E ++K++ +++++ E+E E
Sbjct: 284 DRKRQRRTERDRET---------ERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 328 KEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKR 387
+++EK++ + M + E R++ E E +R + ++ R+ EER + R
Sbjct: 335 RDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREER--ERDR 392
Query: 388 ERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421
+R +QKE+ER+ ++G+ T+ QRE E+
Sbjct: 393 DRDRQKERERQTEKDRDGQRETEKQREREKDRES 426
Score = 97.4 bits (241), Expect = 7e-20
Identities = 85/423 (20%), Positives = 182/423 (43%), Gaps = 42/423 (9%)
Query: 229 AQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVD 288
A K A+ +RER R +E+ + R+ ++ E K+++ ++K+ RK + + +
Sbjct: 45 AHKDADGDDRERN-RQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQR---- 99
Query: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348
E++ E T E D + ++K++ ++K + E E+E ++G + T +E
Sbjct: 100 -----DREKERERQTDRERDRQ---REKERNRQKERERETEREGERGRDRQT-DGQRERE 150
Query: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK---------E 399
+ E+ER+++ + ER ++ E K +E E+ QE+RER++Q+EKE K
Sbjct: 151 RQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGR 210
Query: 400 RLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
++E + T+++R+ + E + + E ++ +R DK+R++ +
Sbjct: 211 ERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDR 270
Query: 460 SKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVE 519
++ + ++ ET E + E + E E E+
Sbjct: 271 DRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERE-------RERNRKRERERER 323
Query: 520 GNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEG-----------SEGDEEDEK 568
+ + + + E+E E + + E + E + EG E D + +
Sbjct: 324 ERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 569 VSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE-ERAYDKAKRRIEKRRLEHSKNVNTE 627
+E++ + D++ +E ++ + D + K+ ER D+ R +R E K E
Sbjct: 384 EREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRE 443
Query: 628 KLR 630
+ R
Sbjct: 444 RDR 446
Score = 93.6 bits (231), Expect = 1e-18
Identities = 69/383 (18%), Positives = 180/383 (46%), Gaps = 17/383 (4%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
K Q +++ K+++ ++K + D +E + + + + DRE + E N ++
Sbjct: 68 KRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKER 127
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
++ +++G++G+ + D E + K ++ + + + K +
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE 187
Query: 153 KAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP-N 211
+ ++ ++ ++ ++ +S++ +ER R + + + + R Q+K ++ +
Sbjct: 188 RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAE 247
Query: 212 IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE 271
E +E + K + + + ++R +K+R+ + + R+ + + + ET +K + +Q+E
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERK-RERQRE 306
Query: 272 SQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKE 331
+R+ E + + E + E E D E ++++K K++ + ++E +
Sbjct: 307 RERERERNRKRERER-------ERERERERQRETERDREKERERKRKRQTEMDRERNRQT 359
Query: 332 KKKGPSKATVKAMQEA---LAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRE 388
++G +A + +E +E EER++ + +R K E K ++ +R +++RE
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRE 419
Query: 389 RKKQKEKER-----KERLKKEGK 406
R+K +E ER +ER K++G+
Sbjct: 420 REKDRESERGRERGREREKQKGR 442
Score = 79.7 bits (195), Expect = 2e-14
Identities = 85/419 (20%), Positives = 173/419 (41%), Gaps = 57/419 (13%)
Query: 240 RKKRDEEKAKLRKLKEKEELETGK-KDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK 298
R+ +E + R L + + G +++++QKE +R+ E+
Sbjct: 29 RRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQ------------------ 70
Query: 299 AETPTAAEDDNEGDKKK-KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER 357
T E D + ++++ KD+ +K+ E++++++K + T + + +E+E
Sbjct: 71 ----TERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERD----RQREKERN 122
Query: 358 QKREEEERIKRLEELEAKR-----KEEERLEQEKRERKKQKEKERK---ERLKKEGKLLT 409
+++E E +R E R +E ER ++ER++Q ++ER+ ER +++ +
Sbjct: 123 RQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERERE 182
Query: 410 KSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMEL 469
K+++E R R K + + ++R + +RK+ + ++ E
Sbjct: 183 KNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERE- 241
Query: 470 CAAVEVMEQGVPEKEETPPPVEPEEEEDTE---DAGLDDWEAMASDEETEKVEGNKVHIE 526
+ E+ + ET E E E D + D + E + + E ++
Sbjct: 242 --REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER 299
Query: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEK-----------DS 575
+E E E E E + E E E E +E D E E+ K +
Sbjct: 300 KRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQT 359
Query: 576 GKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVN----TEKLR 630
G+ ++ +E + E D R +EER D+ + R ++R + K+ + TEK R
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQR 418
Score = 63.9 bits (154), Expect = 9e-10
Identities = 56/340 (16%), Positives = 151/340 (44%), Gaps = 49/340 (14%)
Query: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
G++++ + D+ K+ E + + Q + + ++++EK +Q+ E + +E
Sbjct: 145 GQRERERQRDAEKE--------RERQTDRERQRQTERNRQKEREREKNRQERRERERQRE 196
Query: 62 LEELSLEA---QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELED 118
E + + +G + +RE TE + +D+++K ++ +++ + + E E
Sbjct: 197 KENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERET 256
Query: 119 KDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERS 178
+ K ++ + + D D + ++ + +K ++ + E E ++ +ER
Sbjct: 257 ERDKERERERDR--------DRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308
Query: 179 RINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKER 238
R + E + R+ Q++ ++++ K + +K+ + +R
Sbjct: 309 RERERNRKRERERERERERERQRETERDRE---------------KERERKRKRQTEMDR 353
Query: 239 ERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK 298
ER ++ + + R+ + + E E + QS ++ +R+ + + + K E +
Sbjct: 354 ERNRQTGREGR-RQAERERERERERDRQSAREREERERDRDRDRQK-----------ERE 401
Query: 299 AETPTAAEDDNEGDK---KKKDKKKKKGEKEEKEKEKKKG 335
+T + E +K ++KD++ ++G + +E+EK+KG
Sbjct: 402 RQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441
Score = 61.6 bits (148), Expect = 4e-09
Identities = 57/287 (19%), Positives = 119/287 (41%), Gaps = 12/287 (4%)
Query: 346 EALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEG 405
E L R +E R + L + ++R ++ER++++EK + ER
Sbjct: 19 EVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTER----- 73
Query: 406 KLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSE 465
T +RE R + K + + + + ++ D++R+K + + +E
Sbjct: 74 --ETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERET 131
Query: 466 SMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHI 525
E + G E+E + E + + + E EK N+
Sbjct: 132 EREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK---NRQER 188
Query: 526 EVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSK 585
+E E+E + E+ + E E E E E+E + D + ++ + + +K+ +
Sbjct: 189 RERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAER 248
Query: 586 EMSSDSEYDSDDDRTKE-ERAYDKAKRRIEK-RRLEHSKNVNTEKLR 630
E +S+ E + D +R +E +R D+ +R+ E+ R+ + + TE+ R
Sbjct: 249 ERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR 295
Score = 47.0 bits (110), Expect = 1e-04
Identities = 50/281 (17%), Positives = 121/281 (43%), Gaps = 13/281 (4%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
+++KN+ E ++ E + +E+E ++ + + K++ D + D K
Sbjct: 180 EREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTE 239
Query: 63 EELSLEAQGIKA-DRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
E +A+ +A +RET K E + +D+++K +++ D + ++D
Sbjct: 240 REREKQAERERASERETERDKERERERDRDRDRDRRQK----ERERQTDRKRQRRTERDR 295
Query: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKE--RSR 179
++++ + + E + + + ++ + + ++ + D +E E K+ E R R
Sbjct: 296 ETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRER 355
Query: 180 INSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERE 239
+G G E + R+ ++ Q + E + D + + + + ++E E
Sbjct: 356 NRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETE 415
Query: 240 RKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEET 280
+++ E+ K R E E +++ KQK +R E +T
Sbjct: 416 KQR---EREKDR---ESERGRERGREREKQKGRERDRERQT 450
Score = 42.0 bits (97), Expect = 0.004
Identities = 51/252 (20%), Positives = 92/252 (36%), Gaps = 57/252 (22%)
Query: 385 EKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444
+ RER +QKE+ER+ R K++ + T +RE R
Sbjct: 52 DDRERNRQKERERR-REKRQTERETDRKRERRRE-------------------------- 84
Query: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504
+D+ RK+ + ++ + E E Q E+ + E E +TE G
Sbjct: 85 --KDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNR-----QKERERETEREG-- 135
Query: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDE 564
D +T+ E E + + E+E E + E + + +
Sbjct: 136 ---ERGRDRQTD-------------GQRERERQRDAEKERERQTDRERQRQTERNRQKER 179
Query: 565 EDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEK-----RRLE 619
E EK E+ + +K +K SE + +R +E + KR+ ++ R+ E
Sbjct: 180 EREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTE 239
Query: 620 HSKNVNTEKLRA 631
+ E+ RA
Sbjct: 240 REREKQAERERA 251
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 110 bits (275), Expect = 8e-24
Identities = 141/619 (22%), Positives = 275/619 (44%), Gaps = 80/619 (12%)
Query: 46 KEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKK 105
++++ D DED E++E L + I D+ KP + + T K+K+ KGK+
Sbjct: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKE----KGKE 172
Query: 106 QSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSE 165
+ + E+ K +K KP+ + + K K A+ +K+ K+ G +
Sbjct: 173 KVREKEKPEKKATHKEKIEKKEKPETKTLAKE------QKKAKTAEKSEEKTKKEVKGGK 226
Query: 166 ED--EDNSKKIKERSRINSSGESGDESDEFLQSRKGQKK-------------NQKNKPG- 209
++ + + K+KE + S + ++ ++ S+ QK + KPG
Sbjct: 227 QEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQ 286
Query: 210 -PNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSK 268
P I + AS T A E+KE E+KK +++ K KEKE+++ +
Sbjct: 287 SPAIPPPLPTEQAS--RPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIK-----KKS 339
Query: 269 QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK 328
+KE+ E++ G + + + A ++D++ KK + ++ KG+K+EK
Sbjct: 340 EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK 399
Query: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE----RIKRLEELEAKRKEEERLEQ 384
KEK P+K+ K + ++ K+ + + +R +EE IK+ + + K + +EQ
Sbjct: 400 -KEKHVEPAKSPKK--EHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQ 456
Query: 385 EKRERKKQKEK---ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPK 441
E R+ K K + KE +K + + + S +E + K+ +A G EV K
Sbjct: 457 EIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKA-GKEVKPKP---- 511
Query: 442 KRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDA 501
P + KK +K P+ KE + + V++ +Q + + E+T +PEE
Sbjct: 512 --PQLQGKKEEK-PEPQIKKEAKPA--ISEKVQIHKQDIVKPEKTVSHGKPEE------- 559
Query: 502 GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE-EEEEEGESEGS 560
+ ++V+ + K P ++ E E E ++++ + +G SE +
Sbjct: 560 -----------KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVT 608
Query: 561 EGDEEDEKVSDEKDSGKTLDKKPSKE--MSSDSEYDSDDDRTKEER----AYDKAKRRIE 614
E ++ ++S EK+S + D K +E +S+ E + TK E+ + D
Sbjct: 609 ESGKKKTEIS-EKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPAS 667
Query: 615 KRRLEHSKNVNTEKLRAPI 633
K+ E +++V+ K ++PI
Sbjct: 668 KKAKEGTEDVSPTKQKSPI 686
Score = 80.5 bits (197), Expect = 9e-15
Identities = 128/588 (21%), Positives = 246/588 (41%), Gaps = 81/588 (13%)
Query: 10 EDSTKDDIDLDALAA-EIEGAGAAKEQEPQ-----------KSKGKKKKEKKKQDFDEDD 57
ED+ K +ID L EI K+++P+ K KGK+K +K++ ++
Sbjct: 126 EDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKP-EKKA 184
Query: 58 ILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE 117
KE E + + +E K E +EE+ + K K +K K+ + + ++
Sbjct: 185 THKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTP 244
Query: 118 DKDSKSKKTAKPKVEMYSGSDDDDDFNKL------------------PKKAKGKAQKSNK 159
K + + K V + D + P +A +
Sbjct: 245 SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTP 304
Query: 160 KWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDD 219
EE E KK +++ + S + ++ D +S K + + K E G +
Sbjct: 305 ASPALEEKEGEKKKAEKK--VTSETKKKEKEDIKKKSEKETAIDVEKK-----EPGKASE 357
Query: 220 DASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE---SQRKF 276
+K AQ A+K E KK D +K K K E E+ GKK + K+K ++
Sbjct: 358 TKQGTVKIAAQAAAKKDE---KKEDSKKTK--KPAEVEQ-PKGKKQEKKEKHVEPAKSPK 411
Query: 277 EEETVKSKVTVDTGVIPASEE------KAETPTAAEDDNEGDKKKKDKKKKKGEKEE--K 328
+E +V S V A EE K P E+ +++ +K+K G+ K
Sbjct: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471
Query: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE--EERLEQEK 386
+KE KG + +++E + K++E+ K +E + K +L+ K++E E ++++E
Sbjct: 472 DKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKP-PQLQGKKEEKPEPQIKKEA 530
Query: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIY 446
+ +K + K+ + K K ++ + E E LK ++A +E K +P
Sbjct: 531 KPAISEKVQIHKQDIVKPEKTVSHGKPE-----EKVLKQVKAVTIE-----KTAKPKPTK 580
Query: 447 EDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDW 506
+ + R++ P +++ + + + EV E G K++T E E+E E A D
Sbjct: 581 KAEHREREPPSIKTDKPKPTPK--GTSEVTESG---KKKT----EISEKESKEKA---DM 628
Query: 507 EAMASDEETEKVEGNKVHIEVK-ENPEEEEEEEEEEEEDEESEEEEEE 553
+ + ++ + + E ++H K E P ++ E+ ++++E E+
Sbjct: 629 KHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTED 676
Score = 77.8 bits (190), Expect = 6e-14
Identities = 89/373 (23%), Positives = 162/373 (43%), Gaps = 65/373 (17%)
Query: 295 SEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK---KGPSKATVKAMQEALAKL 351
S E E ED ++G+ + +KK+ K++ EK++K K +K T K ++ K+
Sbjct: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174
Query: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKS 411
+E+E+ +K+ + E++E K K E + +E+KK K E+ E K+
Sbjct: 175 REKEKPEKKATHK-----EKIEKKEKPETK--TLAKEQKKAKTAEKSEE---------KT 218
Query: 412 QREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA 471
++E + + +K A+ EV S PK++ EDK++ + + E + C
Sbjct: 219 KKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEK---EDKEKAAVSKH----EQKDQYAFCR 271
Query: 472 -AVEVMEQG---VPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527
+++ G + PPP+ E+ A A+ E +K KV E
Sbjct: 272 YMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS----PALEEKEGEKKKAEKKVTSET 327
Query: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD---------EEDEKVSD------- 571
K+ E+E+ +++ E+E E++E SE +G ++DEK D
Sbjct: 328 KKK-EKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKP 386
Query: 572 ---EKDSGKTLDKK---------PSKEMS--SDSEYDSDDDRTKEERAYDKAKRRIEKRR 617
E+ GK +KK P KE S SD + + +R KEE K+ + ++
Sbjct: 387 AEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKK 446
Query: 618 LEHSKNVNTEKLR 630
E + +++R
Sbjct: 447 EEKTTKTVEQEIR 459
Score = 71.2 bits (173), Expect = 5e-12
Identities = 105/496 (21%), Positives = 220/496 (44%), Gaps = 59/496 (11%)
Query: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQK--SKGKKKKEKKKQDFDEDDILKE 61
K KSE+ TK ++ E AAK +E QK SK K+K++K+K + + +
Sbjct: 209 KTAEKSEEKTKKEVK--GGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQ 266
Query: 62 LE----ELSLEAQGIKADRETVAVKPTENNEEEFTSKD-----KKKKGQKGKKQSFDDND 112
+ + G ++ A+ P E+ ++K+G+K K + ++
Sbjct: 267 YAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSE 326
Query: 113 SEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSK 172
+++ E +D K K + +++ + + K + +G + + + +E +++SK
Sbjct: 327 TKKKEKEDIKKKSEKETAIDV-----EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSK 381
Query: 173 KIKERSRINS-SGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231
K K+ + + G+ ++ ++ ++ K KK +++ E A +I V+ K
Sbjct: 382 KTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE--RAKEEIGAVSIK 439
Query: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
KA ++E K + ++RK K +GK + + K +EE V + +
Sbjct: 440 KAVPGKKEEKTTKTVEQEIRKEK------SGKTSSILKDKEPIKGKEEKVPASL------ 487
Query: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKAT----VKAMQEA 347
E++ ET + G + K + +G+KEEK + + K +K V+ ++
Sbjct: 488 ---KEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQD 544
Query: 348 LAKLKEEEERQKREEE--ERIKRLE-ELEAKRKEEERLEQEKRERKKQKEKERK------ 398
+ K ++ K EE+ +++K + E AK K ++ E +RE K + K
Sbjct: 545 IVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGT 604
Query: 399 ERLKKEGKLLTK-SQREARARAEATLKLLQAQGVEVPSKDSL------PKKRPIYEDKKR 451
+ + GK T+ S++E++ +A+ +K L+ + V K+SL ++P K
Sbjct: 605 SEVTESGKKKTEISEKESKEKAD--MKHLREEKVST-RKESLQLHNVTKAEKPARVSKDV 661
Query: 452 KKIPQQLESKEVSESM 467
+ +P ++KE +E +
Sbjct: 662 EDVPASKKAKEGTEDV 677
Score = 62.4 bits (150), Expect = 3e-09
Identities = 82/348 (23%), Positives = 129/348 (37%), Gaps = 46/348 (13%)
Query: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Q +D K+D AE+E K+++ +K K KK+ D +K E
Sbjct: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
Query: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSK 124
+ E G + ++ V K E + + +K+K K D + E+K S
Sbjct: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASL 487
Query: 125 KTAKPKVEMYSGSDDDDDFNKLPKKAKGK-AQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
K +P+ + D+ +K K+ K K Q KK E+ E KK
Sbjct: 488 KEKEPETK------KDEKMSKAGKEVKPKPPQLQGKK---EEKPEPQIKK---------- 528
Query: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVA---------QKKAE 234
E+ + + K KP + G ++ ++K V KKAE
Sbjct: 529 -----EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAE 583
Query: 235 KKERERKKRDEEKAKLRKLKEKEELETGKK------DQSKQKESQRKFEEETVKSKVTVD 288
+ERE +K K E E+GKK +SK+K + EE V ++
Sbjct: 584 HREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTR---K 640
Query: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGP 336
+ + KAE P D E KK K+G E+ K+K P
Sbjct: 641 ESLQLHNVTKAEKPARVSKDVE--DVPASKKAKEG-TEDVSPTKQKSP 685
Score = 58.2 bits (139), Expect = 5e-08
Identities = 62/310 (20%), Positives = 133/310 (42%), Gaps = 44/310 (14%)
Query: 351 LKEEEERQKREEEERIK-RLEELEAKRKE---EERLEQEKRERKKQKEKERKERLKKEGK 406
+ E+E +E+ K ++E ++KE ++ +QEK ERK Q + KE+ K + K
Sbjct: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
Query: 407 LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466
+ K + E +A + ++ K P+ + + +++K+ K ++ E K E
Sbjct: 174 VREKEKPEKKATHKEKIE-----------KKEKPETKTLAKEQKKAKTAEKSEEKTKKE- 221
Query: 467 MELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE 526
++ +V + KE P +P+E+ED E A + E + VH +
Sbjct: 222 VKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGD 281
Query: 527 VKENPE----------------------EEEEEEEEEEEDEESEEEEEEEGESEGSEGDE 564
+K EE+E E+++ E + + E +++E E + ++
Sbjct: 282 LKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEK 341
Query: 565 EDEKVSDEKDSGKTLDKK------PSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRL 618
E ++K+ GK + K ++ + E D +TK+ ++ K + ++++
Sbjct: 342 ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE 401
Query: 619 EHSKNVNTEK 628
+H + + K
Sbjct: 402 KHVEPAKSPK 411
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 108 bits (270), Expect = 3e-23
Identities = 116/532 (21%), Positives = 253/532 (47%), Gaps = 73/532 (13%)
Query: 47 EKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQ 106
+KKK D +++ KE + LSLE R T+ +EE K+K K Q+ K Q
Sbjct: 187 QKKKADRYIEELTKERDALSLELY-----RNTIT-------DEEL--KEKNAKLQE-KLQ 231
Query: 107 SFDDNDSE-ELEDKDSKSK-KTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQ---KSNKKW 161
+ SE +L K+ K K + AK + + D K + K Q + N+ W
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 162 DGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDA 221
+ + ++ K ++ +I E E +E ++ ++ + + Q+ K E E ++
Sbjct: 292 NRLNQQQEE-KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 350
Query: 222 SFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV 281
+ + + +K EK R + E++ K+R+L+EK + ++Q ++++ + K E+
Sbjct: 351 MRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410
Query: 282 KSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATV 341
+ E++A+ E E ++K ++++KK +EEK E++K
Sbjct: 411 RQ------------EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK------- 451
Query: 342 KAMQEALAKLKEEEERQKREE----EERIKRLEEL---EAKRKEEERL--EQEKRERKKQ 392
++EEE+RQ++EE EE+I+ EE+ + K E+E++ ++EK R+++
Sbjct: 452 ---------IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEE 502
Query: 393 KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRK 452
K +++E+++++ + + + + + R + E ++ Q ++ ++ + +++ ++ +
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQEEK----IREQEEKIREQEEMMQEQEEKMGEQEE 558
Query: 453 KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASD 512
K+ +Q + + E ++ EQ +E+ E EE+ ++ + + E M +
Sbjct: 559 KMQEQEKMRRQEE--------KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Query: 513 EETEKVEGNKVHIEVKENPEEEEEEEEEEEE---DEESEEEEEEEGESEGSE 561
+E + E + E +E +E+EE+ +EE ++E ++EE E E
Sbjct: 611 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 99.0 bits (245), Expect = 2e-20
Identities = 107/490 (21%), Positives = 234/490 (47%), Gaps = 57/490 (11%)
Query: 178 SRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
SR++ S + E ++ L + QKK K IE ++ DA ++ +++
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKK----KADRYIEELTKERDA-LSLELYRNTITDEEL 219
Query: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE--------SQRKFEEETVKSKVTVDT 289
+E+ + +EK +L + EK E++ K+ ++ E Q + E + + ++ +
Sbjct: 220 KEKNAKLQEKLQLVE-SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 278
Query: 290 GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALA 349
+ A E+ E E ++++K ++ E++ +E+E+K + ++ +E +
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 338
Query: 350 KLKE----EEERQKREEE------ERIKRLEE-----------LEAKRKEEERL-EQEKR 387
+ +E +EE+ +R+EE E+++RLEE LE K E+E++ EQE++
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEK 398
Query: 388 ERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447
++++K +E+++R ++E K+ + + + R + E K+ + + ++ + ++ I E
Sbjct: 399 RQEEEKIREQEKRQEQEAKMW-RQEEKIREQEE---KIREQEKKMWRQEEKIHEQEKIRE 454
Query: 448 DKKRKKIPQQLESKE-VSESMELCAAVEVM-EQGVPEKEETPPPVEPEEEEDTEDAGLDD 505
++KR++ + +E + E E+ E M EQ K+E + E+ D E+ +
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 506 WEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEE----EEEEGESEGSE 561
E M EE K+ + I +E E+EE +E+E++ E+E E+E+ + +
Sbjct: 515 EEKMWRQEE--KIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK 572
Query: 562 GDEEDEKVSDEKDSGKTLDKK---------PSKEMSSDSEYDSDDDRTKEERAYDKAKRR 612
E++EK+ ++K+ + ++K +EM + E + K +K + +
Sbjct: 573 IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632
Query: 613 IEKRRLEHSK 622
EK R + K
Sbjct: 633 EEKMRRQEEK 642
Score = 89.4 bits (220), Expect = 2e-17
Identities = 89/442 (20%), Positives = 214/442 (48%), Gaps = 30/442 (6%)
Query: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
++K + +S K +I L+ KE + + + K +++ + D + KEL+
Sbjct: 227 QEKLQLVESEKSEIQLNV-----------KELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 64 ELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
+S + Q + + + + + EE+ +++K + + K Q ++ E+ E +
Sbjct: 276 SVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 124 KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKK-WDGSEEDEDNSKKIKERSRINS 182
+K + + M+ + ++ + + K ++ + W+ E+ + +K+ E+ +I
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIRE 394
Query: 183 SGESGDESDEFLQSRKGQKKN-----QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
E E ++ + K Q++ Q+ K E E + ++ + ++ + +E
Sbjct: 395 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 238 RERKKRDEEKAKLR-KLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE 296
E+++ EE + K++E+EE+ +K++ ++E RK EE+ + + + E
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWR-QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 297 EKAETPTAAEDDNEGDKKKKDKKKKKGEKEE--KEKEKKKGPSKATVKAMQEALAKLKE- 353
++ + E E ++K +++++K E+EE +E+E+K G + ++ QE + + +E
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQE-QEKMRRQEEK 572
Query: 354 --EEERQKREEEERIKRLEEL----EAKRKEEERLEQEKRERKKQKEKERKERLKKEGKL 407
E+E + RE++E+I+ EE E K +E+E + QE+ E+ ++E++ E+ +K +
Sbjct: 573 IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632
Query: 408 LTKSQREARARAEATLKLLQAQ 429
K +R+ E ++L Q +
Sbjct: 633 EEKMRRQEEKMWEQEVRLRQQE 654
Score = 88.2 bits (217), Expect = 4e-17
Identities = 79/409 (19%), Positives = 203/409 (49%), Gaps = 36/409 (8%)
Query: 22 LAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDE------DDILKELEELSLEAQGIKAD 75
L A++E Q+ + ++E+K Q+++E + I ++ E++ + + ++
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 76 RETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS-EELEDKDSKSKKTAKPKVEMY 134
E + K + +E +K++K ++ ++ ++ + ELE+K + +K + +
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE---- 396
Query: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194
+ + K+ ++ K + Q++ K W E+ + +KI+E+ + E E +
Sbjct: 397 ---EKRQEEEKIREQEKRQEQEA-KMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI 452
Query: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK 254
R+ +K+ ++ + E E ++ + + + +++ +K+ E+ R EEK ++ K
Sbjct: 453 --REEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK 510
Query: 255 EKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKK 314
+E+ E + + K +E + K E+ + K+ ++ EEK + +K
Sbjct: 511 IREQEEKMWRQEEKIREQEEKIREQ--EEKIREQEEMMQEQEEKM--------GEQEEKM 560
Query: 315 KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL----AKLKEEEERQKREEEERIKRLE 370
++ +K ++ E++ +E+E+K K ++ +E + K++E+EE + +EE K E
Sbjct: 561 QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE---KMWE 617
Query: 371 ELEAKRKEEERLEQEKRERKKQKEK--ERKERLKKEGKLLTKSQREARA 417
+ E ++EE++++++ + ++Q+EK E++ RL+++ + + + Q A
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 108 bits (270), Expect = 3e-23
Identities = 146/614 (23%), Positives = 249/614 (40%), Gaps = 119/614 (19%)
Query: 142 DFNKLP----KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197
DF K P K G+ K ++ D+ + +K ++ S ES E ++
Sbjct: 509 DFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKE--ETP 566
Query: 198 KGQKKNQKNKPGPNIESGNE---DDDASFKIKT---VAQKKAEKKERERKKRDEEKAK-L 250
+ K N KP P +ES + D K +T V +K+ KE + E K
Sbjct: 567 EVTKVNHVEKP-PKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA 625
Query: 251 RKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNE 310
+K K E K ++K K +K E+E K +V ++++ +TP E+ +
Sbjct: 626 TDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV---------AKKEDKTPIKKEEKPK 676
Query: 311 GDKKKKDKKK--KKGEKEEKEKE-KKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK 367
++ KK+ KK KK EK+E +KE KK+ P K K ++ KEE++ K+EE+E K
Sbjct: 677 KEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVK------KEEKKEVKKEEKEPKK 730
Query: 368 RLEEL------------EAKR---------KEEERLEQEKRERKKQKEKERKERLKKEGK 406
+++L EAK+ K+EE ++++ K KEK + + +KKEGK
Sbjct: 731 EIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGK 790
Query: 407 LLTKSQREARARAEATLKLLQAQGVEV--PSKDS------LPKKRPIYEDKKRKKIPQQL 458
++ A T ++ A G+ P+K+ + + +D + K +
Sbjct: 791 A-AEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVD 849
Query: 459 ESKEVSESMELCAAVEVMEQGVP--------EKEETPPPVE------------------P 492
+K++ +EL E +++ P E+E T P E P
Sbjct: 850 VTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTP 909
Query: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEE 552
EE E E G+DD E + + E K EE EE EE+ EE +
Sbjct: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
Query: 553 EEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE----YDSDDDRTKEERAYDK 608
E E S E D + ++++S + D + ++M E S+++ +E++A D
Sbjct: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDA 1029
Query: 609 AKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQI 668
+ E ++E V ++DK EAGG +Q
Sbjct: 1030 REEEYEPEKMEAEDYV--------------------MAVVDKA-------AEAGGAEEQY 1062
Query: 669 GATNVPLEAINEQT 682
G P + + Q+
Sbjct: 1063 GFLTTPTKQLGAQS 1076
Score = 86.3 bits (212), Expect = 2e-16
Identities = 134/594 (22%), Positives = 234/594 (39%), Gaps = 83/594 (13%)
Query: 27 EGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTEN 86
E A + P KS K+ KE+ + + + K + S E +K D+
Sbjct: 543 ESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSV 602
Query: 87 NEEEFTSKDKKK--KGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFN 144
E+E SK++ K + +KQ+ D + K+ KK K K E D ++
Sbjct: 603 TEKEVPSKEEPSPVKAEVAEKQA---TDVKPKAAKEKTVKKETKVKPE-----DKKEEKE 654
Query: 145 KLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ 204
K K+ K K+ K + + E+ K++K K KK +
Sbjct: 655 KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK----------------------KEIKKEE 692
Query: 205 KNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK 264
K +P ++ + ++K +K+ +K+E+E KK +++KL + KK
Sbjct: 693 KKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKK------EIKKLP-----KDAKK 741
Query: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKK--KK 322
+ E+++ +K KV P EE + + A G K+K K K KK
Sbjct: 742 SSTPLSEAKK---PAALKPKV-------PKKEESVKKDSVA----AGKPKEKGKIKVIKK 787
Query: 323 GEKEEKEKEKKKGPSKATVKAMQEA------LAKLKEEEERQKREEEERIKRLEELEAKR 376
K + G T M A AK E E E+ K EEL+A+
Sbjct: 788 EGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE 847
Query: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436
+ + + + E + +EK KE E ++ K + + AE+ +G+
Sbjct: 848 VDVTKDIKPQLELIEDEEK-LKETEPVEAYVIQKEREVTKGPAES-----PDEGITTTEG 901
Query: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG-VPEKEETPPPVEPEEE 495
+ ++ P + K+ +E E E E E G EK ET EPEE+
Sbjct: 902 EGECEQTPEELEPVEKQGVDDIEKFE----DEGAGFEESSETGDYEEKAETEEAEEPEED 957
Query: 496 EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKEN-------PEEEEEEEEEEEEDEESE 548
+ + DEE+ K E + E +E+ EE+ +E E+ E E+SE
Sbjct: 958 GEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSE 1017
Query: 549 EEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602
EE +EE ++E + +E + + + +D + K ++ ++ +Y TK+
Sbjct: 1018 EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQ 1071
Score = 79.0 bits (193), Expect = 3e-14
Identities = 127/595 (21%), Positives = 240/595 (40%), Gaps = 42/595 (7%)
Query: 13 TKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGI 72
T+ ++ + ++ A K+ K K K+K KK+ + + KE +E +
Sbjct: 603 TEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAK 662
Query: 73 KADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVE 132
K D+ +K E ++E K+ KK+ +K +K+ +E K+ K + + K E
Sbjct: 663 KEDK--TPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKE 720
Query: 133 M-YSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKI--KERSRINSSGESG-- 187
+ + + KLPK AK KS+ +++ K+ KE S S +G
Sbjct: 721 VKKEEKEPKKEIKKLPKDAK----KSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP 776
Query: 188 DESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEK 247
E + +K K + + A+ I + K + ER E+
Sbjct: 777 KEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDL 836
Query: 248 AKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAED 307
K+ EEL+ + D +K + Q + E+ K K T +E+ T AE
Sbjct: 837 T-----KDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAES 891
Query: 308 DNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK 367
+EG + + + + EE E +K+G ++ ++ A +E E EE
Sbjct: 892 PDEGITTTEGEGECEQTPEELEPVEKQGVD--DIEKFEDEGAGFEESSETGDYEE----- 944
Query: 368 RLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARA----RAEATL 423
+ E EA+ EE+ E K E +E K E + +RE+ A RAE +
Sbjct: 945 KAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDM 1004
Query: 424 KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK 483
+G S++ ++ + ++ + P+++E+++ + A V+ + +
Sbjct: 1005 DEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDY-----VMAVVDKAAEAGGAE 1059
Query: 484 EETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEE 543
E+ P ++ + G + AS E + G E + EE E++ EE
Sbjct: 1060 EQYGFLTTPTKQLGAQSPGREP----ASSIHDETLPGGS-ESEATASDEENREDQPEEFT 1114
Query: 544 DEESEEEEEEEGESEGSEGDEED---EKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
+ E SE + DE + +SDE ++ +T + PS+E + ++Y+S
Sbjct: 1115 ATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEET--ESPSQEFVNITKYES 1167
Score = 38.9 bits (89), Expect = 0.030
Identities = 41/152 (26%), Positives = 57/152 (37%), Gaps = 17/152 (11%)
Query: 312 DKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEE 371
D K+K K KK G K + KK K+ A A LKE ++ R + K E
Sbjct: 2238 DLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVE 2297
Query: 372 LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV 431
AK + K R ++K+KE K +KS + A A T
Sbjct: 2298 KAAK---PTTTPEVKAARGEEKDKETKNAANASA---SKSAKTATAGPGTT--------- 2342
Query: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEV 463
+ ++P P+Y D IP SK V
Sbjct: 2343 KTTKSSAVPPGLPVYLD--LCYIPNHSNSKNV 2372
Score = 30.8 bits (68), Expect = 8.2
Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 5/83 (6%)
Query: 529 ENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSG---KTLDKKPSK 585
+ PEE +EE+ D ES E+ + G ++ + DSG +T+ K
Sbjct: 1873 QKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKT 1932
Query: 586 EMSSDSEYD--SDDDRTKEERAY 606
D Y+ RT EE Y
Sbjct: 1933 PEDGDYSYEIIEKTTRTPEEGGY 1955
>gi|53729339 mitochondrial translational initiation factor 2 precursor
[Homo sapiens]
Length = 727
Score = 107 bits (268), Expect = 5e-23
Identities = 145/590 (24%), Positives = 231/590 (39%), Gaps = 128/590 (21%)
Query: 630 RAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFD 689
R+P++ ++GHVD GKT +LDK R T V E GGITQ IGA V L + + T
Sbjct: 179 RSPVVTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGEKIT------- 231
Query: 690 RENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKC 749
+DTPGH +FS +R RG+ + DI +LVV G+ QT+ESI K +
Sbjct: 232 ----------FLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQV 281
Query: 750 PFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFY 809
P I+A+NK D+ A +K KK E A ++ E
Sbjct: 282 PIILAVNKCDK-----------AEADPEKVKK------ELLAYDVVCE------------ 312
Query: 810 ENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGM 869
D V VP SA TGD + +L V L + ML + + V+E G
Sbjct: 313 ---DYGGDVQAVPVSALTGDNLMALAEATVALAE-MLELKADPNGPVEGTVIESFTDKGR 368
Query: 870 GTTIDVILINGRLKEGDTIIV--------------------------PGVEG-----PIV 898
G I+ G L++G ++ G+ G
Sbjct: 369 GLVTTAIIQRGTLRKGSVLVAGKCWAKVRLMFDENGKTIDEAYPSMPVGITGWRDLPSAG 428
Query: 899 TQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPV 958
+I + P +E+ +YE+ +E + + +KI+ ++ K K +
Sbjct: 429 EEILEVESEPRAREVVDWRKYEQEQE-KGQEDLKII-EEKRKEHKEAHQKAREKYGHLLW 486
Query: 959 LKDELIHELKQTLN-AIKLEEK--------GVYVQASTLGSLEALLEFLKT------SEV 1003
K ++ L++ +K +EK V ++ GS+EA+L + T E+
Sbjct: 487 KKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECEL 546
Query: 1004 PYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIY 1063
+G V DV A VI F+V Q+ A GV+I +IIY
Sbjct: 547 ELVHFGVGDVSANDVNLAETF------DGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIY 600
Query: 1064 HLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILP----------QYIFNSRDPIVMGVT 1113
L + QEE + PC ++ P + V G
Sbjct: 601 RLVE-----------DLQEELS--SRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCR 647
Query: 1114 VEAGQV-KQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIE 1162
V+ GQ+ KQ + + + G +TS++ + + + K G + + ++
Sbjct: 648 VQKGQLEKQKKFKLTRNGHVIWKGSLTSLKHHKDDISIVKTGMDCGLSLD 697
>gi|53729337 mitochondrial translational initiation factor 2 precursor
[Homo sapiens]
Length = 727
Score = 107 bits (268), Expect = 5e-23
Identities = 145/590 (24%), Positives = 231/590 (39%), Gaps = 128/590 (21%)
Query: 630 RAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFD 689
R+P++ ++GHVD GKT +LDK R T V E GGITQ IGA V L + + T
Sbjct: 179 RSPVVTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGEKIT------- 231
Query: 690 RENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKC 749
+DTPGH +FS +R RG+ + DI +LVV G+ QT+ESI K +
Sbjct: 232 ----------FLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQV 281
Query: 750 PFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFY 809
P I+A+NK D+ A +K KK E A ++ E
Sbjct: 282 PIILAVNKCDK-----------AEADPEKVKK------ELLAYDVVCE------------ 312
Query: 810 ENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGM 869
D V VP SA TGD + +L V L + ML + + V+E G
Sbjct: 313 ---DYGGDVQAVPVSALTGDNLMALAEATVALAE-MLELKADPNGPVEGTVIESFTDKGR 368
Query: 870 GTTIDVILINGRLKEGDTIIV--------------------------PGVEG-----PIV 898
G I+ G L++G ++ G+ G
Sbjct: 369 GLVTTAIIQRGTLRKGSVLVAGKCWAKVRLMFDENGKTIDEAYPSMPVGITGWRDLPSAG 428
Query: 899 TQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPV 958
+I + P +E+ +YE+ +E + + +KI+ ++ K K +
Sbjct: 429 EEILEVESEPRAREVVDWRKYEQEQE-KGQEDLKII-EEKRKEHKEAHQKAREKYGHLLW 486
Query: 959 LKDELIHELKQTLN-AIKLEEK--------GVYVQASTLGSLEALLEFLKT------SEV 1003
K ++ L++ +K +EK V ++ GS+EA+L + T E+
Sbjct: 487 KKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECEL 546
Query: 1004 PYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIY 1063
+G V DV A VI F+V Q+ A GV+I +IIY
Sbjct: 547 ELVHFGVGDVSANDVNLAETF------DGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIY 600
Query: 1064 HLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILP----------QYIFNSRDPIVMGVT 1113
L + QEE + PC ++ P + V G
Sbjct: 601 RLVE-----------DLQEELS--SRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCR 647
Query: 1114 VEAGQV-KQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIE 1162
V+ GQ+ KQ + + + G +TS++ + + + K G + + ++
Sbjct: 648 VQKGQLEKQKKFKLTRNGHVIWKGSLTSLKHHKDDISIVKTGMDCGLSLD 697
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 106 bits (264), Expect = 2e-22
Identities = 164/717 (22%), Positives = 296/717 (41%), Gaps = 118/717 (16%)
Query: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKK-EKKKQDFDEDDILKE 61
+KQ + ++ D ++ L A +E K Q S ++ + K+ F+E+ L++
Sbjct: 138 QKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRD 197
Query: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDD--------NDS 113
E ++ A ++ D E ++ E +++ + +D+ + ++ D + +
Sbjct: 198 DTEAAIRA--LRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHIT 255
Query: 114 EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKK 173
E +D TA ++ S D + ++ + K + K + + ++E ++K+
Sbjct: 256 VERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKE 315
Query: 174 IKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKA 233
R +S + L+S +G K++ + + +IE + D +S++ T+ Q +
Sbjct: 316 EIAEYRRQLQSKSIE-----LESVRGTKESLERQLS-DIEERHNHDLSSYQ-DTIQQLEN 368
Query: 234 E----KKERERKKR------------DEEKAKLRKLKEKEELE--------TGK------ 263
E K E R R D E A RKL E EE TG
Sbjct: 369 ELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRP 428
Query: 264 -----------KDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD---- 308
K ++ + + Q KF EE ++ +T V E E TA ++
Sbjct: 429 PITISSKIQKPKVEAPKLKVQHKFVEEIIE-----ETKVEDEKSEMEEALTAITEELAVS 483
Query: 309 -NEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK 367
E K+ ++K+++ E EE+E KK P KAT ++E + +EEE +++ EEE+
Sbjct: 484 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA 543
Query: 368 RLEELE----AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATL 423
+ ++ E K E+ E E+ E + + E E +E KE K + + E + E
Sbjct: 544 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE--- 600
Query: 424 KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQ-LESKEVSESMELCAAVEVMEQGVPE 482
L+ VE P K P + E+K + +P+ +E K S V + V E
Sbjct: 601 -LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKS---------PVPKSPVEE 650
Query: 483 KEETPPPVEPEEEEDTEDAGLDDWEAMA-SDEETEKVEGNKVHIEVKENPEEEEEEEE-- 539
K ++P P P EE+ E A S VE K EV + ++EEEE+E
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710
Query: 540 ---EEEEDEESEEEEEEEGESEGSEGDEEDEKVS---------------DEKDSGKTLDK 581
+EE+ E+ EE+ ++ E + +E ++E V+ + K+ GK L +
Sbjct: 711 EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ 770
Query: 582 KPSKEMS---SDSEYDSDDDRTKEERAYD-------KAKRRIEKRRLEHSKNVNTEK 628
+ KE + SE + D K R D + K +E+ E EK
Sbjct: 771 EKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 827
Score = 92.4 bits (228), Expect = 2e-18
Identities = 113/478 (23%), Positives = 209/478 (43%), Gaps = 74/478 (15%)
Query: 210 PNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQ 269
P +E+ F + + + K E ++ E ++ + + KEE KK+ +++
Sbjct: 439 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE----KKEAAEE 494
Query: 270 KESQRKFEEETVKSKVTVDTGVIP------ASEEKAETPTAAEDDNEG---DKKKKDKKK 320
KE + + EEE V +K + P +E+ E E+++EG D+ ++ +
Sbjct: 495 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 554
Query: 321 KKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE 380
K+G E++E E+++G ++A + +EA AK EE++ E+ E + EEL A K E+
Sbjct: 555 KEGSSEKEEGEQEEGETEAEAEG-EEAEAK----EEKKVEEKSEEVATKEELVADAKVEK 609
Query: 381 RLEQEKRERKKQKEKERKERLKK-----EGKL-LTKSQREARARAEATLKLLQAQG---- 430
+ + K E++ K + K +GK + KS E + ++ ++ +G
Sbjct: 610 PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 669
Query: 431 ----VEVPSKDSLPKKRPIYEDKKRKKI----PQQLESKEVSESM--ELCAAVEVMEQGV 480
VE +K +PK P+ E K + ++ ++ E KEV E+ E E + V
Sbjct: 670 SKSPVEEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDV 728
Query: 481 PEKEETPPPVEPE----------------------------EEEDTEDAGLDDWEAMASD 512
PEK++ PV+ E +E++ E AG E + +
Sbjct: 729 PEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAG---GEGGSEE 785
Query: 513 EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEG-ESEGSEGDEEDEKVSD 571
E ++K ++ N E E +EE E+E E+ EEE+G + G + DEK
Sbjct: 786 EGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGG 845
Query: 572 EKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKL 629
+K K + K ++++S+ + TK K + E K V+T+K+
Sbjct: 846 DKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVE---EHEETFEEKLVSTKKV 900
Score = 87.8 bits (216), Expect = 6e-17
Identities = 135/564 (23%), Positives = 224/564 (39%), Gaps = 86/564 (15%)
Query: 136 GSDDDDDFNKLPKKAKGKAQKSNKKWDGSEED----EDNSKKIKE-----RSRINSSGES 186
GS D+ K + Q N ++ G E E +K+I+ R + S +
Sbjct: 87 GSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQL 146
Query: 187 GDESD-EFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDE 245
GD D E + R + K ++S + ++D + E+ E E + RD+
Sbjct: 147 GDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDI--------HRLKERFEEEARLRDD 198
Query: 246 EKAKLRKLKEKEE------LETGKKDQSKQKES---QRKFEEE-------------TVKS 283
+A +R L++ E +E KK QS Q E + EEE TV+
Sbjct: 199 TEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVER 258
Query: 284 KVTVDTGVIPASEEKAETPTAAEDDN--EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATV 341
K + T + A +E + D N + ++ K + K E E+ KE + +
Sbjct: 259 KDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIA 318
Query: 342 KAMQEALAK---------LKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392
+ ++ +K KE ERQ + EER +L + + ++LE E R K +
Sbjct: 319 EYRRQLQSKSIELESVRGTKESLERQLSDIEERHNH--DLSSYQDTIQQLENELRGTKWE 376
Query: 393 KEKERKE-------------RLKKEGKLLTKSQREARARAEATLKLLQAQG--VEVPSKD 437
+ +E + KLL + A + L + + SK
Sbjct: 377 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 436
Query: 438 SLPKKRPIYEDKKRKKIPQQLESKEVSES---MELCAAVEVMEQGVPEKEETPPPVEPEE 494
PK + K + + +E +V + ME E V KEE E +E
Sbjct: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496
Query: 495 EEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEE-----DEESEE 549
EE + E +A+ + K +V E E EEE +EEEEEE+ D+ E
Sbjct: 497 EEPEAEE-----EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 551
Query: 550 EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKA 609
E+EG SE EG++E+ + E + G+ + K K++ E S++ TKEE D
Sbjct: 552 GSEKEGSSEKEEGEQEEGETEAEAE-GEEAEAKEEKKV----EEKSEEVATKEELVADAK 606
Query: 610 KRRIEKRRLEHSKNVNTEKLRAPI 633
+ EK + K+ EK ++P+
Sbjct: 607 VEKPEKAKSPVPKSPVEEKGKSPV 630
Score = 73.9 bits (180), Expect = 8e-13
Identities = 104/476 (21%), Positives = 206/476 (43%), Gaps = 54/476 (11%)
Query: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
M +++K +E+ ++ + A + A E ++ +G+K++E+ +++ +E+D
Sbjct: 484 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED--- 540
Query: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
+G K+D+ E E +K++G++ + ++ + + EE E K+
Sbjct: 541 ---------EGAKSDQ-------AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE 584
Query: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDG-----SEEDEDNSKKIK 175
K + +V D K P+KAK KS + G E+ K
Sbjct: 585 EKKVEEKSEEVATKEELVADAKVEK-PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 643
Query: 176 ERSRINSSGES---GDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKK 232
+S + G+S +E +S + ++ P +S E+ A+ K
Sbjct: 644 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE----------AKSK 693
Query: 233 AEKKERERKKRDEEKAKLRKLKEK-EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
AE + E+K+ +E++ K +EK E+ E KD ++K+++ +EE V VT+ V
Sbjct: 694 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 753
Query: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351
K +++ + +++K+K+K GE +E +G K + +E +A
Sbjct: 754 ------KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE----EGSDKGAKGSRKEDIAVN 803
Query: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEK-ERKERLKKEGKLLTK 410
E E +++ E+E + K E K L+ + KK +K E K + K + +T
Sbjct: 804 GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKIT- 862
Query: 411 SQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466
S+ A T + Q VE +++ +K + KK +K+ KEV++S
Sbjct: 863 SEGGDGATKYITKSVTVTQKVE-EHEETFEEK--LVSTKKVEKVTSHAIVKEVTQS 915
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 106 bits (264), Expect = 2e-22
Identities = 99/348 (28%), Positives = 152/348 (43%), Gaps = 59/348 (16%)
Query: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD---KKKK 321
D+ +++S + E + ++T+ P E + EDD+ K + K+K
Sbjct: 6 DRDSKRDSLEEGELRDHRMEITIRNS--PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 63
Query: 322 KGEKEEKEKEKKKGPSKATV------KAMQEALAKLKEEEERQKREEEERIK------RL 369
K+EK KEKK K K +E K + E ERQKR E R RL
Sbjct: 64 HHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRL 123
Query: 370 EELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQ 429
E+LE KR+ E ++ ++++E+++QKE+ER+ +++ +REAR A + +
Sbjct: 124 EQLERKRERERKMREQQKEQREQKERERRAEERRK-------EREARREVSAHHRTM--- 173
Query: 430 GVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPP 489
R Y DK + + + E EL + P KEE
Sbjct: 174 -------------REDYSDKVKASHWSRSPPRPPRERFELGDGRK------PVKEEKME- 213
Query: 490 VEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE 549
E + D +D + D E S E+ E E +E EEEEEE EE EE EE
Sbjct: 214 -ERDLLSDLQD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEE 270
Query: 550 EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597
EEEEE E GS +E E+ ++E +EMS D E ++++
Sbjct: 271 EEEEEEEETGSNSEEASEQSAEEVS---------EEEMSEDEERENEN 309
Score = 95.1 bits (235), Expect = 4e-19
Identities = 73/296 (24%), Positives = 139/296 (46%), Gaps = 35/296 (11%)
Query: 312 DKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQE----ALAKLKEEEERQKREEEERIK 367
D+K+K+KK + +++E+E E++K + KA +E ++ E R++R+ E+++
Sbjct: 68 DEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLE 127
Query: 368 RLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
R E E K +E+++ ++E++ER+++ E+ RKER + S R + + K+
Sbjct: 128 RKRERERKMREQQKEQREQKERERRAEERRKEREARR----EVSAHHRTMREDYSDKVKA 183
Query: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETP 487
+ P + P++R D ++ +++E +++ + Q + + E
Sbjct: 184 SHWSRSPPRP--PRERFELGDGRKPVKEEKMEERDLLSDL----------QDISDSERKT 231
Query: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547
E E + E +EE E+ EG+ + E EEEEEEEEEE+EE+
Sbjct: 232 SSAESSSAESGSGS-----EEEEEEEEEEEEEGS-------TSEESEEEEEEEEEEEEET 279
Query: 548 EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEE 603
EE E E EE+ +E+++ L P DS + + +EE
Sbjct: 280 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS---GESEEAEEE 332
Score = 67.0 bits (162), Expect = 1e-10
Identities = 75/396 (18%), Positives = 163/396 (41%), Gaps = 36/396 (9%)
Query: 109 DDNDS-----EELEDKDSKSKKTAKPKV-----EMYSGSDDDDDFNKLPKKAKGKAQKSN 158
DD DS EE E +D + + T + M ++DD P + + +K +
Sbjct: 5 DDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVH 64
Query: 159 KKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL------QSRKGQKKNQKNKPGPNI 212
+ D +++ +++ +KE+ R + + E + Q R+ + + +
Sbjct: 65 HRKDEKRKEKKHAR-VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRL 123
Query: 213 ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKES 272
E + K++ +++ E+KERER+ + K + + + T ++D S + ++
Sbjct: 124 EQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKA 183
Query: 273 QR--KFEEETVKSKVTVDTGVIPASEEKAETP---TAAEDDNEGDKKKKDKKKKKGE--- 324
+ + + + G P EEK E + +D ++ ++K + E
Sbjct: 184 SHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGS 243
Query: 325 -KEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLE 383
EE+E+E+++ + + E EEEE ++ EEEE E EA + E +
Sbjct: 244 GSEEEEEEEEEEEEEGSTSEESE------EEEEEEEEEEEETGSNSE--EASEQSAEEVS 295
Query: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443
+E+ +++E E + E + S A E Q+ + D +P
Sbjct: 296 EEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSA--LTEGDYVPDSP 353
Query: 444 PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG 479
+ + ++++P+ L + + S+E + +E+G
Sbjct: 354 ALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEG 389
Score = 57.8 bits (138), Expect = 6e-08
Identities = 87/413 (21%), Positives = 163/413 (39%), Gaps = 52/413 (12%)
Query: 8 KSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSL 67
+ EDS +D + D A +++++ K +K+KEKK E + E +
Sbjct: 34 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 93
Query: 68 EAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS-EELEDKDSKSKKT 126
E Q KA RE +++K+ + ++ S + D E+LE K + +K
Sbjct: 94 EEQD-KARREW----------------ERQKRREMAREHSRRERDRLEQLERKRERERKM 136
Query: 127 AKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGES 186
+ + E + + + ++ K + + ED S K+K S
Sbjct: 137 REQQKEQREQKERE---RRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRP 193
Query: 187 GDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEE 246
E E RK K +K + + + D+ K + AE ++ +EE
Sbjct: 194 PRERFELGDGRK-PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 252
Query: 247 KAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAE 306
+ +E+EE T ++ + +++E + + EE S+ + SEE+ E
Sbjct: 253 E------EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 306
Query: 307 DDNEGDKKKKDK-KKKKGEKEEKEKEKKKG----------------PSKATVKAMQEALA 349
++N + + + GE EE E+E +G P+ + ++ QE
Sbjct: 307 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK 366
Query: 350 KLKEEEERQKREEEERIKRLEE------LEAKRKEEERLEQEKRERKKQKEKE 396
L + + EE + + R+EE AK K+ + + KR K +KEKE
Sbjct: 367 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKR-LKMEKEKE 418
Score = 40.0 bits (92), Expect = 0.014
Identities = 33/132 (25%), Positives = 60/132 (45%), Gaps = 15/132 (11%)
Query: 495 EEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE----EEEEEEEEDEESEEE 550
E+ ED G +D +++A + KVH E +E++ +E+E E E + E
Sbjct: 36 EDSMEDRGEED-DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHRE 94
Query: 551 EEEEGESEGSEGDEED---EKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYD 607
E+++ E + E E+D + L++K +E ++ KE+R
Sbjct: 95 EQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM-------REQQKEQREQK 147
Query: 608 KAKRRIEKRRLE 619
+ +RR E+RR E
Sbjct: 148 ERERRAEERRKE 159
Score = 32.3 bits (72), Expect = 2.8
Identities = 21/90 (23%), Positives = 41/90 (45%), Gaps = 10/90 (11%)
Query: 541 EEEDEESEEEEEEEGESEGSEGD--------EEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
+ +D +S+ + EEGE + ++ + D + +L KP ++MS +
Sbjct: 3 QSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK 62
Query: 593 --YDSDDDRTKEERAYDKAKRRIEKRRLEH 620
+ D+ R +++ A K K R +RR H
Sbjct: 63 VHHRKDEKRKEKKHARVKEKEREHERRKRH 92
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 105 bits (262), Expect = 3e-22
Identities = 101/349 (28%), Positives = 159/349 (45%), Gaps = 26/349 (7%)
Query: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD---KKKK 321
D+ +++S + E + ++T+ P E + EDD+ K + K+K
Sbjct: 6 DRDSKRDSLEEGELRDHRMEITIRNS--PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 63
Query: 322 KGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEER 381
K+EK KEK++ S + + + + E ER+KR EE+ K E E +++ E
Sbjct: 64 HHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMA 123
Query: 382 LEQEKRERKKQKEKERK---ERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDS 438
E +RER + ++ ERK ER +E + + Q+E RAE K +A+ EV +
Sbjct: 124 REHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARR-EVSAHHR 182
Query: 439 LPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDT 498
R Y DK + + + E EL + P KEE E + D
Sbjct: 183 T--MREDYSDKVKASHWSRSPPRPPRERFELGDGRK------PVKEEKME--ERDLLSDL 232
Query: 499 EDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE---EEEEEEDEESEEEEEEEG 555
+D + D E S E+ E E +E EEEEEE EE EE+EE EEEEEEE
Sbjct: 233 QD--ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 290
Query: 556 ESEGSEGDEED-EKVSDEKDS-GKTLDKKPSKEMSSDSEYDSDDDRTKE 602
S E E+ E+VS+E+ S + + + + +S +D D ++E
Sbjct: 291 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 339
Score = 62.4 bits (150), Expect = 3e-09
Identities = 83/400 (20%), Positives = 165/400 (41%), Gaps = 33/400 (8%)
Query: 109 DDNDS-----EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDG 163
DD DS EE E +D + + T + S +D K Q S K+
Sbjct: 5 DDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVH 64
Query: 164 SEEDEDNSKKIKERSRINSSGESGDESD-EFLQSRKGQKKNQKNKPGPNIESGNEDDDA- 221
+DE +K + RS G+ + E R+ + + +++K E + A
Sbjct: 65 HRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 124
Query: 222 --SFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE-- 277
S + + ++ K+ERERK R+++K + +E++E E +++ K++E++R+
Sbjct: 125 EHSRRERDRLEQLERKRERERKMREQQKEQ----REQKERERRAEERRKEREARREVSAH 180
Query: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPS 337
T++ + S P + +G K K++K ++ + ++
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 240
Query: 338 KATVKAMQEALAKLKEEEERQKREEEERI-KRLEELEAKRKEEERLEQE----------- 385
K + A + EEE ++ EEEE EE E + +EEE E+E
Sbjct: 241 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 300
Query: 386 KRERKKQKEKERKERLKKEGKLL----TKSQREARARAEATLKLLQA--QGVEVPSKDSL 439
E ++E E + E LL ++ R++ EA ++ + Q + D +
Sbjct: 301 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 360
Query: 440 PKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG 479
P + + ++++P+ L + + S+E + +E+G
Sbjct: 361 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEG 400
Score = 50.8 bits (120), Expect = 8e-06
Identities = 78/394 (19%), Positives = 152/394 (38%), Gaps = 71/394 (18%)
Query: 27 EGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTEN 86
EG A+ +E ++ ++K+ +++QD KA RE
Sbjct: 83 EGGKHARVKEKEREHERRKRHREEQD--------------------KARREW-------- 114
Query: 87 NEEEFTSKDKKKKGQKGKKQSFDDNDS-EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNK 145
+++K+ + ++ S + D E+LE K + +K + + E + + +
Sbjct: 115 --------ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERE---RR 163
Query: 146 LPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK 205
++ K + + ED S K+K S E E RK K +K
Sbjct: 164 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK-PVKEEK 222
Query: 206 NKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKD 265
+ + + D+ K + AE ++ +EE+ +E+EE T ++
Sbjct: 223 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE------EEEEEGSTSEES 276
Query: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK-KKKKGE 324
+ +++E + + EE S+ + SEE+ E++N + + + GE
Sbjct: 277 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE 336
Query: 325 KEEKEKEKKKG----------------PSKATVKAMQEALAKLKEEEERQKREEEERIKR 368
EE E+E +G P+ + ++ QE L + + EE + + R
Sbjct: 337 SEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNR 396
Query: 369 LEE------LEAKRKEEERLEQEKRERKKQKEKE 396
+EE AK K+ + + KR K +KEKE
Sbjct: 397 IEEGTYGVVYRAKDKKTDEIVALKR-LKMEKEKE 429
Score = 35.4 bits (80), Expect = 0.33
Identities = 33/143 (23%), Positives = 59/143 (41%), Gaps = 26/143 (18%)
Query: 495 EEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE---------------EEEE 539
E+ ED G +D +++A + KVH E +E+ +E+E
Sbjct: 36 EDSMEDRGEED-DSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKE 94
Query: 540 EEEEDEESEEEEEEEGESEGSEGDEED---EKVSDEKDSGKTLDKKPSKEMSSDSEYDSD 596
E E + EE+++ E + E E+D + L++K +E
Sbjct: 95 REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM------- 147
Query: 597 DDRTKEERAYDKAKRRIEKRRLE 619
++ KE+R + +RR E+RR E
Sbjct: 148 REQQKEQREQKERERRAEERRKE 170
Score = 32.7 bits (73), Expect = 2.2
Identities = 30/132 (22%), Positives = 60/132 (45%), Gaps = 21/132 (15%)
Query: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD 563
DD ++ E ++ +++ I ++ +P E+ E+ E+++S + + S
Sbjct: 5 DDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSR----- 59
Query: 564 EEDEKVSDEKDSGKTLDKKPSKEMSSD-------SEYDSDDDRTKEER-AYDKAKRRIEK 615
EKV KD K +K+ + S++ E + + +R K R DKA+R E+
Sbjct: 60 --KEKVHHRKDE-KRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWER 116
Query: 616 RR-----LEHSK 622
++ EHS+
Sbjct: 117 QKRREMAREHSR 128
Score = 30.8 bits (68), Expect = 8.2
Identities = 24/115 (20%), Positives = 58/115 (50%), Gaps = 11/115 (9%)
Query: 11 DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ 70
DS + ++ +AE G+G+ +E+E ++ + ++ ++ + +E++ +E EE
Sbjct: 237 DSERKTSSAESSSAE-SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG---- 291
Query: 71 GIKADRETVAVKPTENNEEEFTSKDKKKKGQKG---KKQSFDDNDSEELEDKDSK 122
++ E + + E EE S+D++++ + +S D DS E E+ + +
Sbjct: 292 ---SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 343
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 105 bits (261), Expect = 3e-22
Identities = 106/406 (26%), Positives = 176/406 (43%), Gaps = 59/406 (14%)
Query: 264 KDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD-----NEGDKKKKDK 318
K ++ + + Q KF EE ++ +T V E E TA ++ E K+ ++
Sbjct: 64 KVEAPKLKVQHKFVEEIIE-----ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
Query: 319 KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELE----A 374
K+++ E EE+E KK P KAT ++E + +EEE +++ EEE+ + ++ E
Sbjct: 119 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 178
Query: 375 KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP 434
K E+ E E+ E + + E E +E KE K + + E + E L+ VE P
Sbjct: 179 KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE----LVADAKVEKP 234
Query: 435 SKDSLPKKRPIYEDKKRKKIPQQ-LESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493
K P + E+K + +P+ +E K S V + V EK ++P P P
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKS---------PVPKSPVEEKGKSPVPKSPV 285
Query: 494 EEEDTEDAGLDDWEAMA-SDEETEKVEGNKVHIEVKENPEEEEEEEE-----EEEEDEES 547
EE+ E A S VE K EV + ++EEEE+E +EE+ E+
Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 345
Query: 548 EEEEEEEGESEGSEGDEEDEKVS---------------DEKDSGKTLDKKPSKEMS---S 589
EE+ ++ E + +E ++E V+ + K+ GK L ++ KE +
Sbjct: 346 EEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEG 405
Query: 590 DSEYDSDDDRTKEERAYD-------KAKRRIEKRRLEHSKNVNTEK 628
SE + D K R D + K +E+ E EK
Sbjct: 406 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
Score = 99.0 bits (245), Expect = 2e-20
Identities = 107/431 (24%), Positives = 200/431 (46%), Gaps = 66/431 (15%)
Query: 226 KTVAQKKAEKKERERKKRDEEKAKLRKLKEK--EELETG----KKDQSKQKESQRKFEEE 279
K Q K ++ E K ++EK+++ + EEL KK+ +++KE + + EEE
Sbjct: 69 KLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE 128
Query: 280 TVKSKVTVDTGVIP------ASEEKAETPTAAEDDNEG---DKKKKDKKKKKGEKEEKEK 330
V +K + P +E+ E E+++EG D+ ++ +K+G E++E
Sbjct: 129 EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG 188
Query: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERK 390
E+++G ++A + +EA AK EE++ E+ E + EEL A K E+ E+ K
Sbjct: 189 EQEEGETEAEAEG-EEAEAK----EEKKVEEKSEEVATKEELVADAK-VEKPEKAKSPVP 242
Query: 391 KQKEKER------KERLKKEGKL-LTKSQREARARAEATLKLLQAQG--------VEVPS 435
K +E+ K ++++GK + KS E + ++ ++ +G VE +
Sbjct: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA 302
Query: 436 KDSLPKKRPIYEDKKRKKI----PQQLESKEVSES--MELCAAVEVMEQGVPEKEETPPP 489
K +PK P+ E K + ++ ++ E KEV E+ E E + VPEK++ P
Sbjct: 303 KSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361
Query: 490 VEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE 549
V+ E A E + KVH+E + E + ++E+E+E E
Sbjct: 362 VKEE----------------AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEG 405
Query: 550 EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS-------DDDRTKE 602
EEEG +G++G +++ + + GK ++ +KE S E + D E
Sbjct: 406 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADE 465
Query: 603 ERAYDKAKRRI 613
++ DK++ ++
Sbjct: 466 KKGGDKSEEKV 476
Score = 90.5 bits (223), Expect = 9e-18
Identities = 126/514 (24%), Positives = 223/514 (43%), Gaps = 67/514 (13%)
Query: 38 QKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKK 97
QK K + K K + F E+ I EE +E + + + A+ EE S ++
Sbjct: 61 QKPKVEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTAI-----TEELAVSMKEE 111
Query: 98 KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKS 157
KK +K+ + + EE+ K S K TA P+V+ G ++++ + ++ A+
Sbjct: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
Query: 158 NKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNE 217
+ GSE++ + K+ E+ + E+ E E + +K ++K+
Sbjct: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS-------------- 216
Query: 218 DDDASFKIKTVAQKKAEKKERER----KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQ 273
++ + K + VA K EK E+ + K EEK K K E E GK K +
Sbjct: 217 -EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE-EKGKSPVPK-SPVE 273
Query: 274 RKFEEETVKSKVTVDTGVIPAS----EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKE 329
K + KS V + G P S EEKA++P E K K + K +KEE+E
Sbjct: 274 EKGKSPVPKSPVE-EKGKSPVSKSPVEEKAKSPVPKSPVEEA--KSKAEVGKGEQKEEEE 330
Query: 330 KEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRER 389
KE K+ P + V+ +E + E+++ + +EE + E + + + LE+E +E
Sbjct: 331 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV--AEVVTITKSVKVHLEKETKEE 388
Query: 390 KK--QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447
K Q+EKE+++ + G S + A+ + + A EV K+ + +
Sbjct: 389 GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDI----AVNGEVEGKEE------VEQ 438
Query: 448 DKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507
+ K K ++ E V+ ++L A E ++G +K E V E+ T + G
Sbjct: 439 ETKEKGSGREEEKGVVTNGLDLSPADE--KKG-GDKSEEKVVVTKTVEKITSEGG----- 490
Query: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEE 541
D T+ + + + V + EE EE EE+
Sbjct: 491 ----DGATKYITKS---VTVTQKVEEHEETFEEK 517
Score = 89.7 bits (221), Expect = 1e-17
Identities = 111/516 (21%), Positives = 217/516 (42%), Gaps = 57/516 (11%)
Query: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
S K KPKVE ++ ++ K + +KS + + E+ + +KE +
Sbjct: 57 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK--E 114
Query: 183 SGESGDESDEFLQSRKGQKKNQKNKPGPNI--ESGNEDDDASFKIKTVAQKKAEKKERER 240
+ E +E E + KK+ P + E G ++++ + + + A+ + E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 241 KKRDEEKAKLRKLKEKEELET-----GKKDQSKQ-KESQRKFEEETVKSKVTVDTGVIPA 294
++E + ++ E+EE ET G++ ++K+ K+ + K EE K ++ D V
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 295 SEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE-EKEKEKKKGPSKATVKAMQEALAKLKE 353
+ K+ P + ++ K ++KG+ K ++KG S ++E K
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE-----KG 289
Query: 354 EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQR 413
+ K EE+ K + + + E K E+K+++EKE KE K+E
Sbjct: 290 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE--------- 340
Query: 414 EARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAV 473
+V K+ PK P ++KK ++ + V+E + + +V
Sbjct: 341 ------------------KVEKKEEKPKDVP-----EKKKAESPVKEEAVAEVVTITKSV 377
Query: 474 EVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEE 533
+V + ++E P E E+E+ + G ++ E + + E V+ EV E
Sbjct: 378 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE-EGSDKGAKGSRKEDIAVNGEV-----E 431
Query: 534 EEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEY 593
+EE E+E +++ S EEE+ + G + DEK +K K + K ++++S+
Sbjct: 432 GKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491
Query: 594 DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKL 629
+ TK K + E K V+T+K+
Sbjct: 492 GATKYITKSVTVTQKVE---EHEETFEEKLVSTKKV 524
Score = 85.1 bits (209), Expect = 4e-16
Identities = 125/534 (23%), Positives = 222/534 (41%), Gaps = 72/534 (13%)
Query: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
K ++K + ++ ++ +E+E A A +E S KE+KK+ +E + E
Sbjct: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSM----KEEKKEAAEEKE-----E 121
Query: 64 ELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
E E + + A + V E EEE G+K+ + + EE ED+ +KS
Sbjct: 122 EPEAEEEEVAAKKSPVKATAPEVKEEE------------GEKEEEEGQEEEEEEDEGAKS 169
Query: 124 KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
+ + GS+ + K ++ + + ++ + +G E + KK++E+S
Sbjct: 170 DQAEE------GGSEKEGSSEK--EEGEQEEGETEAEAEGEEAEAKEEKKVEEKS----- 216
Query: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKR 243
E +E + K +K + P P +S E+ S K+ ++K K K
Sbjct: 217 -EEVATKEELVADAKVEKPEKAKSPVP--KSPVEEKGKSPVPKSPVEEKG--KSPVPKSP 271
Query: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQR------KFEEETVKSKVTVDTGVIPASEE 297
EEK K K E E GK SK ++ K E KSK V G E+
Sbjct: 272 VEEKGKSPVPKSPVE-EKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG-----EQ 325
Query: 298 KAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER 357
K E E+ + K++K +KK EK + EKKK S +A+ E + K +
Sbjct: 326 KEE-----EEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVH 380
Query: 358 QKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARA 417
++E +E K L++ + K K E+ K + RKE + G++ K + E
Sbjct: 381 LEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 440
Query: 418 RAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK-IPQQLESKEVSESMELCAAVEVM 476
+ + + + + +GV D P DK +K + + K SE + A + +
Sbjct: 441 KEKGSGR-EEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGD--GATKYI 497
Query: 477 EQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKEN 530
+ V ++ EE E+T + E + S ++ EKV + + EV ++
Sbjct: 498 TKSVTVTQKV------EEHEETFE------EKLVSTKKVEKVTSHAIVKEVTQS 539
Score = 73.9 bits (180), Expect = 8e-13
Identities = 104/476 (21%), Positives = 206/476 (43%), Gaps = 54/476 (11%)
Query: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
M +++K +E+ ++ + A + A E ++ +G+K++E+ +++ +E+D
Sbjct: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED--- 164
Query: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
+G K+D+ E E +K++G++ + ++ + + EE E K+
Sbjct: 165 ---------EGAKSDQ-------AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE 208
Query: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDG-----SEEDEDNSKKIK 175
K + +V D K P+KAK KS + G E+ K
Sbjct: 209 EKKVEEKSEEVATKEELVADAKVEK-PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 267
Query: 176 ERSRINSSGES---GDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKK 232
+S + G+S +E +S + ++ P +S E+ A+ K
Sbjct: 268 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE----------AKSK 317
Query: 233 AEKKERERKKRDEEKAKLRKLKEK-EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
AE + E+K+ +E++ K +EK E+ E KD ++K+++ +EE V VT+ V
Sbjct: 318 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
Query: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351
K +++ + +++K+K+K GE +E +G K + +E +A
Sbjct: 378 ------KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE----EGSDKGAKGSRKEDIAVN 427
Query: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEK-ERKERLKKEGKLLTK 410
E E +++ E+E + K E K L+ + KK +K E K + K + +T
Sbjct: 428 GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKIT- 486
Query: 411 SQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466
S+ A T + Q VE +++ +K + KK +K+ KEV++S
Sbjct: 487 SEGGDGATKYITKSVTVTQKVE-EHEETFEEK--LVSTKKVEKVTSHAIVKEVTQS 539
Score = 68.6 bits (166), Expect = 4e-11
Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 18/211 (8%)
Query: 431 VEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES---MELCAAVEVMEQGVPEKEETP 487
+ + SK PK + K + + +E +V + ME E V KEE
Sbjct: 54 ITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK 113
Query: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEE---- 543
E +EEE + E +A+ + K +V E E EEE +EEEEEE+
Sbjct: 114 EAAEEKEEEPEAEE-----EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAK 168
Query: 544 -DEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602
D+ E E+EG SE EG++E+ + E + G+ + K K++ E S++ TKE
Sbjct: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-GEEAEAKEEKKV----EEKSEEVATKE 223
Query: 603 ERAYDKAKRRIEKRRLEHSKNVNTEKLRAPI 633
E D + EK + K+ EK ++P+
Sbjct: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPV 254
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 104 bits (259), Expect = 6e-22
Identities = 62/196 (31%), Positives = 116/196 (59%), Gaps = 5/196 (2%)
Query: 229 AQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVD 288
+++K E++ERE++KR+ EK + R+ +KE+ + K+++ K++E +RK E+ K + +
Sbjct: 34 SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93
Query: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348
+EK + E KKK+ K++++ K+ +E+++KK K K +
Sbjct: 94 RR--KRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLL 408
+ K E +R+KR++EER K+ E K +++ER +E+RERKK+++KER R KKE K
Sbjct: 152 ERGKRERKRKKRKKEEREKK-RERNRKERKKERERKERRERKKERKKER--RKKKERKKD 208
Query: 409 TKSQREARARAEATLK 424
K+ R+ ++ L+
Sbjct: 209 RKTDRQTDSQVFRPLR 224
Score = 75.5 bits (184), Expect = 3e-13
Identities = 54/235 (22%), Positives = 107/235 (45%), Gaps = 50/235 (21%)
Query: 164 SEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASF 223
++ + + K+ +ER + E + + + +K +KK ++ K E
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 224 KIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKS 283
+ K ++K EKK+RERK+R + K +K +++ E E ++ + K+K+ ++K +
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRK---- 145
Query: 284 KVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKA 343
E E ++ K+++K+KK +KEE+EK
Sbjct: 146 ----------------------ERKREKERGKRERKRKKRKKEEREK------------- 170
Query: 344 MQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK 398
K E R++R++E K E + +RK+E R +K+ERKK ++ +R+
Sbjct: 171 --------KRERNRKERKKERERKERRERKKERKKERR---KKKERKKDRKTDRQ 214
Score = 73.9 bits (180), Expect = 8e-13
Identities = 42/163 (25%), Positives = 89/163 (54%), Gaps = 2/163 (1%)
Query: 303 TAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE 362
T E + + ++++++K+K++ EKE K + KK K + + + ++E E+Q++E
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 363 EERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEAT 422
E+ +R + E K++E R ++ +RERKK+KE++ +ER K+ + + +R + R +
Sbjct: 90 REKERRKRKKEKKKRE--RKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKER 147
Query: 423 LKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSE 465
+ + E K ++R ++ RK+ ++ E KE E
Sbjct: 148 KREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRE 190
Score = 73.2 bits (178), Expect = 1e-12
Identities = 49/185 (26%), Positives = 96/185 (51%), Gaps = 22/185 (11%)
Query: 269 QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK 328
Q+ES+RK E E+ + E + + ++ KK+KKK+K + K
Sbjct: 31 QRESERKKERR-----------------EREKRKREREKERKRERGKKEKKKRKKRERGK 73
Query: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRE 388
E+E+K+ + K +E + K ++E++KRE ++R +R + + +RKE ER +++RE
Sbjct: 74 ERERKRKEREKQRKERREK-ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132
Query: 389 RKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYED 448
RK++K +++K R +++ + +R R R K + + ++ K+R E
Sbjct: 133 RKRKKRRKKKRRKERK----REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKER 188
Query: 449 KKRKK 453
++RKK
Sbjct: 189 RERKK 193
Score = 68.6 bits (166), Expect = 4e-11
Identities = 52/223 (23%), Positives = 101/223 (45%), Gaps = 25/223 (11%)
Query: 76 RETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYS 135
RE+ K E+ ++K++K ++GKK+ E ++++ K K+ K + E
Sbjct: 32 RESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE 91
Query: 136 GSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQ 195
K ++ K + ++ KK +E E +K+ +ER R
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR---------------- 135
Query: 196 SRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKE 255
+K +KK ++ + E G + + K +KK E+ +ERKK E K + + KE
Sbjct: 136 -KKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE 194
Query: 256 KEELETGKKDQSKQKESQRKFE-------EETVKSKVTVDTGV 291
+++ KK++ K +++ R+ + E+ ++VTV TGV
Sbjct: 195 RKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRVTV-TGV 236
Score = 60.5 bits (145), Expect = 1e-08
Identities = 54/210 (25%), Positives = 99/210 (47%), Gaps = 34/210 (16%)
Query: 350 KLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERK-KQKEKERKERLKKE---- 404
K + E E++KRE E+ KR + K+K ++R ++RERK K++EK+RKER +KE
Sbjct: 38 KERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKR 97
Query: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS 464
K K +R+ R R E K E ++ K+R + KKR+K ++ E K
Sbjct: 98 KKEKKKRERKQRGRRERKKK------KERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 465 ESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVH 524
E+G E++ E E++ + +E +K K
Sbjct: 152 ------------ERGKRERKRKKRKKEEREKKRERNR-----------KERKKERERKER 188
Query: 525 IEVKENPEEEEEEEEEEEEDEESEEEEEEE 554
E K+ ++E +++E ++D +++ + + +
Sbjct: 189 RERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 59.3 bits (142), Expect = 2e-08
Identities = 59/256 (23%), Positives = 102/256 (39%), Gaps = 56/256 (21%)
Query: 353 EEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQ 412
+ E +K+E ER KR E E +RK E R ++EK++RKK++ + +ER +KE + K +
Sbjct: 31 QRESERKKERREREKRKREREKERKRE-RGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAA 472
RE R KR + K+ +K + E K+ E E
Sbjct: 90 REKERR-----------------------KRKKEKKKRERKQRGRRERKKKKERKE---- 122
Query: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPE 532
E+ ++ E +++ E + EK G + K E
Sbjct: 123 ---RERENKQRRERKRKKRRKKKRRKE-------------RKREKERGKRERKRKKRKKE 166
Query: 533 EEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
E E++ E ++ + E E +E E + E +K K+ K+ +D +
Sbjct: 167 EREKKRERNRKERKKERERKERRERKKERKKERRKK------------KERKKDRKTDRQ 214
Query: 593 YDSDDDRTKEERAYDK 608
DS R E A+++
Sbjct: 215 TDSQVFRPLRESAFNR 230
Score = 52.4 bits (124), Expect = 3e-06
Identities = 40/177 (22%), Positives = 82/177 (46%), Gaps = 17/177 (9%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
+E+E ++ + + KKEKKK+ E KE E E + + +R K ++E
Sbjct: 48 REREKERKRERGKKEKKKRKKRERG--KERERKRKEREKQRKERRE---KERRKRKKEKK 102
Query: 93 SKDKKKKG--QKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150
+++K++G ++ KK+ + + E + ++ K KK K K + +K
Sbjct: 103 KRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRK----------ERKREKE 152
Query: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207
+GK ++ KK E ++ + KER + E + E + R+ +K+ +K++
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR 209
Score = 39.7 bits (91), Expect = 0.018
Identities = 24/111 (21%), Positives = 48/111 (43%), Gaps = 6/111 (5%)
Query: 526 EVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD------EEDEKVSDEKDSGKTL 579
E +E + + E E+E + + +E+++ + G E + E+ K EK+ K
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRK 98
Query: 580 DKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
+K +E + + ++ER + +RR KR+ K E+ R
Sbjct: 99 KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR 149
Score = 39.3 bits (90), Expect = 0.023
Identities = 31/176 (17%), Positives = 72/176 (40%), Gaps = 7/176 (3%)
Query: 453 KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASD 512
K+ +L+ S + C E + E+ E E+E + G + +
Sbjct: 12 KLNTELQMVSCSHISKPCTQRE--SERKKERREREKRKREREKERKRERGKKEKKKRKKR 69
Query: 513 EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDE 572
E ++ E + KE ++ +E E+E + E+++ E + E ++ E+ E
Sbjct: 70 ERGKERERKR-----KEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERE 124
Query: 573 KDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
+++ + ++K K + ++ + +R + KR+ E+R + +N K
Sbjct: 125 RENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERK 180
Score = 38.9 bits (89), Expect = 0.030
Identities = 49/254 (19%), Positives = 99/254 (38%), Gaps = 72/254 (28%)
Query: 376 RKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPS 435
++E ER ++E+RER+K+K + KER ++ GK +E + R
Sbjct: 31 QRESER-KKERREREKRKREREKERKRERGK------KEKKKR----------------- 66
Query: 436 KDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEE 495
KKR ++++RK+ ++ + KE E KE E ++
Sbjct: 67 -----KKRERGKERERKRKEREKQRKERRE-----------------KERRKRKKEKKKR 104
Query: 496 EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEG 555
E K G + E +++E +E E E + E + ++
Sbjct: 105 E-------------------RKQRGRR------ERKKKKERKERERENKQRRERKRKKRR 139
Query: 556 ESE-GSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIE 614
+ + E E E+ E+ K ++ K+ + + + KE R K +++
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER 199
Query: 615 KRRLEHSKNVNTEK 628
+++ E K+ T++
Sbjct: 200 RKKKERKKDRKTDR 213
Score = 38.1 bits (87), Expect = 0.052
Identities = 25/107 (23%), Positives = 47/107 (43%), Gaps = 5/107 (4%)
Query: 524 HIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP 583
HI E E ++E E ++ E E+E G ++++K +++ GK ++K
Sbjct: 24 HISKPCTQRESERKKERREREKRKREREKERKRERG----KKEKKKRKKRERGKERERK- 78
Query: 584 SKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
KE + + +R K ++ K +R+ RR K E+ R
Sbjct: 79 RKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERER 125
Score = 35.0 bits (79), Expect = 0.44
Identities = 29/171 (16%), Positives = 74/171 (43%), Gaps = 11/171 (6%)
Query: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
GKK+K K + + E E +E++ ++ + K+++++KK+ + +
Sbjct: 59 GKKEKKKRKKRER--------GKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRG 110
Query: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
E + + + +RE K + + K K++K +K +K+ + K+
Sbjct: 111 RRERKKKKERKEREREN---KQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEE 167
Query: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSK 172
+ KK + + E + + + ++ K + +K +K D + + +S+
Sbjct: 168 REKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 34.7 bits (78), Expect = 0.57
Identities = 25/114 (21%), Positives = 51/114 (44%), Gaps = 12/114 (10%)
Query: 528 KENPEEEEEEEEEEEED------EESEEEEEEEGESEGSEGDEEDEKVSD-----EKDSG 576
++ E E++ +E E++ E+ + E ++ G E + E E+ + E+
Sbjct: 77 RKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRK 136
Query: 577 KTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
K KK KE + E + + K+ + ++ K+R E+ R E K ++ R
Sbjct: 137 KRRKKKRRKERKREKERGKRERKRKKRKKEEREKKR-ERNRKERKKERERKERR 189
Score = 31.2 bits (69), Expect = 6.3
Identities = 20/99 (20%), Positives = 46/99 (46%)
Query: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
KE+E + + +++K KK++ K +E + K ++ K E N +E
Sbjct: 121 KERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERK 180
Query: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKV 131
+ ++K+ ++ KK+ + ++ KD K+ + +V
Sbjct: 181 KERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 104 bits (259), Expect = 6e-22
Identities = 95/407 (23%), Positives = 207/407 (50%), Gaps = 41/407 (10%)
Query: 47 EKKKQDFDEDDILKELEELSLEA-------QGIKAD----RETVAVKPTENNEEEFTSKD 95
+KKK D +++ KE + LSLE + +K +E + + +E +E + K+
Sbjct: 175 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 234
Query: 96 KKKKGQKGKKQSFDDNDSEELE-DKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKA 154
K+K ++ K ++L+ + D K+ ++ + ++++ +N+L +
Sbjct: 235 LKRKLERAKLLL----PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ------ 284
Query: 155 QKSNKKWDGSEEDEDNSKKIKERS-RINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIE 213
Q+ K W E+ ++ +KI+E+ +I E +E + ++ + + Q+ E
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 344
Query: 214 SGNEDDDASFKIKTVAQKKAEKKE----RERKKRDEEKAKLRKLKEK--EELETGKKDQS 267
E ++ + + + +++ +++E RE++KR E++AK+ + +EK E+ E ++ +
Sbjct: 345 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 404
Query: 268 KQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEE 327
+E + K E+ + K+ + EEK E E +KK +++++K E+EE
Sbjct: 405 MMQEQEEKMGEQ--EEKMWEQEEEMQEQEEKMR--RQEEKIREQEKKIREQEEKIREQEE 460
Query: 328 --KEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEE---ERIKRLEELEAKRKEEERL 382
+E+E+K G + M E AK++E+EE+ +R+EE E+ K++ E E K +E+E +
Sbjct: 461 MMQEQEEKMGEQEG---KMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 517
Query: 383 EQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQ 429
QE+ E+ ++E++ E+ +K + K +R+ E ++L Q +
Sbjct: 518 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQE 564
Score = 93.6 bits (231), Expect = 1e-18
Identities = 87/419 (20%), Positives = 213/419 (50%), Gaps = 33/419 (7%)
Query: 178 SRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
SR++ S + E ++ L + QKK K IE ++ DA ++ +++
Sbjct: 153 SRLHDSWKFAGELEQALSAVATQKK----KADRYIEELTKERDA-LSLELYRNTITDEEL 207
Query: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE--------SQRKFEEETVKSKVTVDT 289
+E+ + +EK +L + EK E++ K+ ++ E Q + E + + ++ +
Sbjct: 208 KEKNAKLQEKLQLVE-SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 266
Query: 290 GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALA 349
+ A E+ E E ++++K ++ E++ +E+E+K + ++ +E +
Sbjct: 267 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMW 326
Query: 350 KLKEEEERQKR---EEEERIKRLEELEAKRKEEERL-EQEKRERKKQKEKERKERLKKEG 405
+ +E+ RQ+ E+EE+I+ LEE K E+E++ EQE++ ++++K +E+++R ++E
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEE---KMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 383
Query: 406 KLLTKSQ--REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEV 463
K+ + + RE + +++Q Q ++ ++ ++E ++ + ++ ++
Sbjct: 384 KMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE-----EKMWEQEEEMQEQEEKMRRQE 438
Query: 464 SESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKV 523
+ E + E+ + E+EE E EE+ ++ + + EA ++E EK+ +
Sbjct: 439 EKIREQEKKIREQEEKIREQEEMMQ--EQEEKMGEQEGKMCEQEAKMQEQE-EKM--RRQ 493
Query: 524 HIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKK 582
+++E ++ E+EE+ E EE +E+EE+ + + E++EK+ ++++ + ++K
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552
Score = 90.1 bits (222), Expect = 1e-17
Identities = 74/374 (19%), Positives = 184/374 (49%), Gaps = 37/374 (9%)
Query: 36 EPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVK---PTENNE--EE 90
E +KS+ + ++ K+ + +L ++L EA + + ++V+ K E NE
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 281
Query: 91 FTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150
+ ++K ++ +K + +E E+K + ++ + + EM + +K
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEM------------MWEKE 329
Query: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210
+ ++ W+ E+ + +K+ E+ +I E E ++ + K Q+ Q+ K
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE--QEAKMWR 387
Query: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK 270
E E ++ + + + Q++ EK + +K E++ ++++ +EK ++ + K +
Sbjct: 388 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKM-----RRQEEKIR 442
Query: 271 ESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
E ++K E+ + K+ ++ EEK + E +++++K ++ E++ +E+
Sbjct: 443 EQEKKIREQ--EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQ 500
Query: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERK 390
EKK ++E K++E+EE +E+EE++ EE +++E+ + ++EK R+
Sbjct: 501 EKK----------IREQEEKIREQEE-MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 549
Query: 391 KQKEKERKERLKKE 404
++K +E++ RL+++
Sbjct: 550 EEKMREQEVRLRQQ 563
Score = 80.5 bits (197), Expect = 9e-15
Identities = 80/399 (20%), Positives = 190/399 (47%), Gaps = 54/399 (13%)
Query: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
++K + +S K +I L+ KE + + + K +++ + D + KEL+
Sbjct: 215 QEKLQLVESEKSEIQLNV-----------KELKRKLERAKLLLPQQQLQAEADHLGKELQ 263
Query: 64 ELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
+S + Q + + + + + EE+ +++K + ++ K Q ++ E+ E+K +
Sbjct: 264 SVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQ-EEKMRRQ 321
Query: 124 KKTAKPKVEMYSGSDD-----DDDFNKLPKKA--KGKAQKSNKKWDGSEEDEDNSKKIKE 176
++ K E ++ ++ +L +K + K ++ +K E+ + K+ ++
Sbjct: 322 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 381
Query: 177 RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKK 236
+++ E E +E ++ ++ + Q+ K G E ++ ++ + Q++ EK
Sbjct: 382 EAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG-------EQEEKMWEQEEEMQEQEEKM 434
Query: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE 296
R+ +K E++ K+R+ +EK ++ + +E + K E+ K E
Sbjct: 435 RRQEEKIREQEKKIREQEEKI-----REQEEMMQEQEEKMGEQEGK-----------MCE 478
Query: 297 EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356
++A+ E ++K ++++KK E+EEK +E++ + MQE K+ E+EE
Sbjct: 479 QEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE--------EMMQEQEEKMWEQEE 530
Query: 357 RQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEK 395
+ +EE K E+ E R++EE++ +++ ++Q+EK
Sbjct: 531 KMCEQEE---KMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 69.7 bits (169), Expect = 2e-11
Identities = 89/408 (21%), Positives = 178/408 (43%), Gaps = 50/408 (12%)
Query: 236 KERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPAS 295
K+ E + RD K ELE + QK+ ++ EE K + +
Sbjct: 142 KQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSL------ 195
Query: 296 EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL--AKLKE 353
E T T D++ K+K K EK + E +K + VK ++ L AKL
Sbjct: 196 ELYRNTIT--------DEELKEKNAKLQEKLQLV-ESEKSEIQLNVKELKRKLERAKLLL 246
Query: 354 EEERQKREEEERIKRLEELEAKRK---EEERL-------EQEKRERKKQKEKERKERLKK 403
+++ + E + K L+ + AK + EE L ++EK R+++K +ER+E++++
Sbjct: 247 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQE 306
Query: 404 EGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEV 463
+ + + + + + R + E + K+ +++ +K +KI +E+
Sbjct: 307 QEEKIREQEEKMRRQEEMMWE-----------KEEKMRRQEEMMWEKEEKI------REL 349
Query: 464 SESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKV 523
E M + E+ E+E+ + +E+ ++A + E ++E EK+ +
Sbjct: 350 EEKMHEQEKIREQEEKRQEEEK----IREQEKRQEQEAKMWRQEEKIREQE-EKIREQEE 404
Query: 524 HIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP 583
++ +E E+EE+ E+E+E E+EE+ + E E+ + +EK + +
Sbjct: 405 MMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 464
Query: 584 SKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK-NVNTEKLR 630
+E + E + K + +K +R+ EK R + K EK+R
Sbjct: 465 QEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 103 bits (256), Expect = 1e-21
Identities = 113/523 (21%), Positives = 247/523 (47%), Gaps = 65/523 (12%)
Query: 47 EKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQ 106
+KKK D +++ KE + LSLE R T+ +EE K+K K Q+ K Q
Sbjct: 248 QKKKADRYIEELTKERDALSLELY-----RNTIT-------DEEL--KEKNAKLQE-KLQ 292
Query: 107 SFDDNDSE-ELEDKDSKSK-KTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQ---KSNKKW 161
+ SE +L K+ K K + AK + + D K + K Q + N+ W
Sbjct: 293 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 352
Query: 162 DGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDA 221
+ + ++ K ++ +I E E +E ++ ++ + + Q+ K E E ++
Sbjct: 353 NRLNQQQEE-KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 411
Query: 222 SFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV 281
+ + + +K EK R+ + E++ K+R+L+EK + ++Q ++++ + K E+
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 471
Query: 282 KSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATV 341
+ E++A+ E E ++K +++++K +EEK E++K
Sbjct: 472 RQ------------EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK------- 512
Query: 342 KAMQEALAKLKEEEERQKREE----EERIKRLEEL----EAKRKEEERL--EQEKRERKK 391
++EEE+RQ++EE EE+I+ EE+ E ++EE++ ++EK R++
Sbjct: 513 ---------IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563
Query: 392 QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKR 451
+K +++E+++++ + + + + + R + E ++ Q ++ ++ + +++ ++
Sbjct: 564 EKMHDQEEKIREQEEKVWRQEEKIREQEEK----IREQEEKIREQEEMTQEQEEKMGEQE 619
Query: 452 KKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEE-EDTEDAGLDDWEAMA 510
+K+ +Q E + E ++ EQ +E+ E EE ++ E+ + E M
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Query: 511 SDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553
EE + + K+ + +E E+E ++EE + +E E
Sbjct: 680 EQEEKMQEQEEKMRRQ-EEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 100 bits (249), Expect = 8e-21
Identities = 96/473 (20%), Positives = 227/473 (47%), Gaps = 56/473 (11%)
Query: 114 EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKK 173
EEL++K++K ++ K+++ + N K+ K K +++ + +
Sbjct: 278 EELKEKNAKLQE----KLQLVESEKSEIQLNV--KELKRKLERAKLLLPQQQLQAEADHL 331
Query: 174 IKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNED-DDASFKIKTVAQKK 232
KE +++ ++ E +E Q++ + + I+ E + KI+ +K
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391
Query: 233 AEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVI 292
E++E+ R++ + K K++ +EE+ K+++ +++E +EE ++
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR---------- 441
Query: 293 PASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK 352
E E E E ++K+++++K + +++ +E+E K + ++ +E K++
Sbjct: 442 ----ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE---KIR 494
Query: 353 EEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQ 412
E+EE+ R+EE ++ E E R+EE+R EQE+ R+++K +E++E +++ K+ +
Sbjct: 495 EQEEKMWRQEE----KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI---HE 547
Query: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAA 472
+E + R + Q + + + ++ ++ ++ +KI +Q
Sbjct: 548 QEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVW--RQEEKIREQ--------------- 590
Query: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPE 532
E+ + E+EE E +E E G + E M EE + + K+ + ++ E
Sbjct: 591 ----EEKIREQEEKIREQEEMTQEQEEKMGEQE-EKMCEQEEKMQEQEEKMRRQEEKIRE 645
Query: 533 EEEEEEEEEEEDEESEE---EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKK 582
+E++ E+EE+ E EE E+EE+ + + E++EK+ ++++ + ++K
Sbjct: 646 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 698
Score = 97.1 bits (240), Expect = 9e-20
Identities = 95/421 (22%), Positives = 212/421 (50%), Gaps = 34/421 (8%)
Query: 224 KIKTVAQKKAEKKERERK-KRDEEKAKLRKLKEKEELET---GKKDQSKQKESQRKFEEE 279
K++ V +K+E + ++ KR E+AKL +++ + E GK+ QS + Q + EE
Sbjct: 290 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 349
Query: 280 TVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK--EKEKKKGPS 337
+ +++ +++ + E E ++K +++++K E+EEK E+E+K
Sbjct: 350 ELWNRLN--------QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 338 KATVKAMQEALAKLKE----EEERQKREEE---ERIKRLEELEAKRKEEERL-EQEKRER 389
+ + +E + + +E +EE+ +R+EE E+ +++ ELE K E+E++ EQE++ +
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 461
Query: 390 KKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDK 449
+++K +E+++R ++E K+ + + + R + E K+ + + ++ + ++ I E++
Sbjct: 462 EEEKIREQEKRQEQEAKMW-RQEEKIREQEE---KIREQEEKMWRQEEKIHEQEKIREEE 517
Query: 450 KRKKIPQQLESKE-VSESMELCAAVEVMEQGVPE--KEETPPPVEPEEEEDTEDAGLDDW 506
KR++ + +E + E E+ E + + + K+E + E+ D E+ +
Sbjct: 518 KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQE 577
Query: 507 EAMASDEET-----EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSE 561
E + EE EK+ + I +E +E+EE+ E+E++ E+EE+ + + E
Sbjct: 578 EKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMR 637
Query: 562 GDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHS 621
EE + ++K + + +EM + E + K +K + + EK R +
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 697
Query: 622 K 622
K
Sbjct: 698 K 698
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/438 (20%), Positives = 215/438 (49%), Gaps = 27/438 (6%)
Query: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
++K + +S K +I L+ KE + + + K +++ + D + KEL+
Sbjct: 288 QEKLQLVESEKSEIQLNV-----------KELKRKLERAKLLLPQQQLQAEADHLGKELQ 336
Query: 64 ELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
+S + Q + + + + + EE+ +++K + + K Q ++ E+ E +
Sbjct: 337 SVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 395
Query: 124 KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKK-WDGSEEDEDNSKKIKERSRINS 182
+K + + M+ + ++ + + K ++ + W+ E+ + +K+ E+ +I
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 455
Query: 183 SGESGDESDEFLQSRKGQKKN-----QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
E E ++ + K Q++ Q+ K E E ++ ++ + ++ + +E
Sbjct: 456 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIRE 515
Query: 238 RERKKRDEEKAKLR-KLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE 296
E+++ EE + K++E+EE+ K+ +Q+E RK EE+ + + + E
Sbjct: 516 EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIRE 575
Query: 297 EKAETPTAAEDDNEGDKKKKDKKKKKGEKEE--KEKEKKKGPSKATVKAMQEALAKLKEE 354
++ + E E ++K +++++K E+EE +E+E+K G + + +E K++E+
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE---KMQEQ 632
Query: 355 EER-QKREEE--ERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKS 411
EE+ +++EE+ E+ K++ E E K +E+E + QE+ E+ ++E++ E+ +K + K
Sbjct: 633 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 692
Query: 412 QREARARAEATLKLLQAQ 429
+R+ E ++L Q +
Sbjct: 693 RRQEEKMWEQEVRLRQQE 710
Score = 89.0 bits (219), Expect = 3e-17
Identities = 82/404 (20%), Positives = 200/404 (49%), Gaps = 31/404 (7%)
Query: 22 LAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDE------DDILKELEELSLEAQGIKAD 75
L A++E Q+ + ++E+K Q+++E + I ++ E++ + + ++
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 76 RETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS-EELEDKDSKSKKTAKPKVEMY 134
E + K + +E +K++K ++ ++ ++ + ELE+K + +K + +
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE---- 457
Query: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERS-RINSSGESGDESDEF 193
+ + K+ ++ K + Q++ K W E+ + +KI+E+ ++ E E ++
Sbjct: 458 ---EKRQEEEKIREQEKRQEQEA-KMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI 513
Query: 194 LQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253
+ K Q++ + + I +++ K K Q++ +K+ E+ R EEK ++
Sbjct: 514 REEEKRQEQEEMWRQEEKIRE--QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEE 571
Query: 254 KEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
K +E+ E + + K +E + K E+ K + E++ T E E ++
Sbjct: 572 KIREQEEKVWRQEEKIREQEEKIREQEEKIR-----------EQEEMTQEQEEKMGEQEE 620
Query: 314 KKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELE 373
K ++++K E+EEK + +++ + K ++E K++E+EE +E+EE++ EE
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEE-KIREQEKKIREQEEKIREQEEMM-QEQEEKMWEQEEKM 678
Query: 374 AKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARA 417
+++E+ + ++EK R+++K E++ RL+++ + + + Q A
Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 77.4 bits (189), Expect = 8e-14
Identities = 99/466 (21%), Positives = 217/466 (46%), Gaps = 58/466 (12%)
Query: 178 SRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
SR++ S + E ++ L + QKK K IE ++ DA ++ +++
Sbjct: 226 SRLHDSWKFAGELEQALSAVATQKK----KADRYIEELTKERDA-LSLELYRNTITDEEL 280
Query: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE 297
+E+ + +EK +L + EK E+ Q KE +RK E + ++P +
Sbjct: 281 KEKNAKLQEKLQLVE-SEKSEI------QLNVKELKRKLERAKL---------LLPQQQL 324
Query: 298 KAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER 357
+AE D+ G + + K + + EE E + Q+ K+ +EE+
Sbjct: 325 QAEA------DHLGKELQSVSAKLQAQVEENELWNRLN---------QQQEEKMWRQEEK 369
Query: 358 QKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEK-ERKERLKKEGKLLTKSQREAR 416
+ E EE+I+ EE + + +EE+ EQE++ R++++ E++E+++++ +++ + + + R
Sbjct: 370 IQ-EWEEKIQEQEE-KIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 427
Query: 417 ARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVM 476
+ E + + + ++ + ++ I E +++++ +++ +E + E A +
Sbjct: 428 RQEE---MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE--AKMWRQ 482
Query: 477 EQGVPEKEETPPPVEP----EEEEDTEDAGLDDWEAMASDEE----TEKVEGNKVHIEVK 528
E+ + E+EE E +EE+ E + + E EE EK+ + K
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 542
Query: 529 ENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDE----EDEKVSDEKDSGKTLDKK-- 582
E E+EE+ ++EE +EE+ + E + E +E ++EK+ ++++ + ++K
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602
Query: 583 PSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
+EM+ + E + K +K + + EK R + K EK
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEK 648
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 102 bits (255), Expect = 2e-21
Identities = 101/484 (20%), Positives = 215/484 (44%), Gaps = 67/484 (13%)
Query: 94 KDKKKKGQKGKKQSFDDNDSEELEDKDSKSK-KTAKPKVEM----YSG-----SDDDDDF 143
K KKK + ND EE D+++K + + K +E+ YS S + D
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
Query: 144 NKLPKKAKGKAQKSNKKWDGS--------EEDEDNSKKIKERSRINSSGESGDESDEFLQ 195
+ KK K K + +++ + +++ N+ +++E R S E D
Sbjct: 233 PR--KKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRD--TH 288
Query: 196 SRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKE 255
+ ++K +K K IE + + +++ E++ERER++ E + + K +E
Sbjct: 289 KKLEEEKGKKEKERQEIEKERRERERE------RERERERREREREREREREREKEKERE 342
Query: 256 KEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKK 315
+E +D++K+++ R E + ++ + +D + +K
Sbjct: 343 RERERDRDRDRTKERDRDRDRERD--------------RDRDRERSSDRNKDRSRSREKS 388
Query: 316 KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE-EERIKRLEELEA 374
+D+++++ + E+E+E+++ + + + + +E+++++ REE EE +LE
Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448
Query: 375 KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP 434
K +E+E QE+ + + +E+++ +KE + + +RE A+ + L+
Sbjct: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD---D 505
Query: 435 SKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEE 494
+D R K+ + +++E+ E E E+ ++ + E P
Sbjct: 506 DRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDP------- 558
Query: 495 EEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEE 554
D E ++E E+ + ++K+ PE EEEEEE++E++E+ EE EEE
Sbjct: 559 ----------DAELQRMEQEAER----RRQPQIKQEPESEEEEEEKQEKEEKREEPMEEE 604
Query: 555 GESE 558
E E
Sbjct: 605 EEPE 608
Score = 99.4 bits (246), Expect = 2e-20
Identities = 109/542 (20%), Positives = 236/542 (43%), Gaps = 76/542 (14%)
Query: 96 KKKKGQKGKKQSFDDNDSEELE---------------DKDSKSKKTAKPKVEMYSGSDDD 140
K+ +G GK Q+F + +E E +K K AK K ++
Sbjct: 117 KRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQL------- 169
Query: 141 DDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKE----------RSRINSSGESGDES 190
D++ K + G A+ D E ++ +K+ + R + ES
Sbjct: 170 DEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQES 229
Query: 191 DEFLQSRKGQKKNQKNKPGP-------------NIESGNEDDDASFKIKTVAQKKAEKKE 237
D + +K +KK + P +I + ++D + + ++ K
Sbjct: 230 DSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDK----RDLISREISKFR 285
Query: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE 297
KK +EEK K K KE++E+E ++++ +++E +R+ E + + E
Sbjct: 286 DTHKKLEEEKGK--KEKERQEIEKERRERERERERERERRERERERE----------RER 333
Query: 298 KAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER 357
+ E E + E D+ + D+ K++ ++E+++ + +++ + + ++ K +
Sbjct: 334 EREKEKERERERERDRDR-DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRE 392
Query: 358 QKREEEERIKRLEELEAKRKEEERLEQEK-RERKKQKEKERKERLKKEGKLLTKSQREAR 416
++RE E +R E E +R+ E E+E+ RER+K K+++R+E +++ K +R+ R
Sbjct: 393 REREREREREREREREREREREREREREREREREKDKKRDREED-EEDAYERRKLERKLR 451
Query: 417 ARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESME-------- 468
+ A + L+ + K +K E+++R+++ + E+K + E +E
Sbjct: 452 EKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK--EAKRLKEFLEDYDDDRDD 509
Query: 469 -LCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527
+++ + ++E+ E + + + E+ +A E ++ E
Sbjct: 510 PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEA 569
Query: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM 587
+ + + ++E E EE+EE E++E+EE E E +EE E+ K + + + PS
Sbjct: 570 ERRRQPQIKQEPESEEEEE-EKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSS 628
Query: 588 SS 589
+S
Sbjct: 629 AS 630
Score = 85.1 bits (209), Expect = 4e-16
Identities = 91/401 (22%), Positives = 176/401 (43%), Gaps = 39/401 (9%)
Query: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE 297
+ + + DE KAK + ET D + + + K ++ +K + V +I
Sbjct: 164 KTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEV---LIREYSS 220
Query: 298 KAETPTAAEDDNEGDKKKKDKKK------------------KKGEKEEKEKEKKKGPSKA 339
+ P+ E D+ KKKK+KK+ K+ + +E K+
Sbjct: 221 ELNAPSQ-ESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISR 279
Query: 340 TVKAMQEALAKLKEEEERQKRE----EEERIKRLEELEAKRKEEERLEQEKRERKKQKEK 395
+ ++ KL+EE+ ++++E E+ER +R E E +R+ ER + +RER+++KEK
Sbjct: 280 EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEK 339
Query: 396 ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIP 455
ER ER ++ + +++ R R + + +KD + R D++R++
Sbjct: 340 ER-ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR-SRSREKSRDRERERER 397
Query: 456 QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET 515
++ +E E E + E+E+ E+EED + E ++E
Sbjct: 398 EREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR--KLERKLREKEA 455
Query: 516 EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDS 575
E K + E++E + E E+E E E+E E +E + D +D++ +
Sbjct: 456 AYQERLK-NWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYR 514
Query: 576 GKTLDKK---PSKEMSSDSEYDSDDDRTKEERAYDKAKRRI 613
G L K+ KEM +D + DR +E+ ++ ++R+
Sbjct: 515 GSALQKRLRDREKEMEAD-----ERDRKREKEELEEIRQRL 550
Score = 84.0 bits (206), Expect = 8e-16
Identities = 104/561 (18%), Positives = 230/561 (40%), Gaps = 46/561 (8%)
Query: 19 LDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRET 78
++ L E A QE KKKKEKK +DI + L + +
Sbjct: 211 IEVLIREYSSELNAPSQESDSHPRKKKKEKK------EDIFRRFPVAPLIPYPLITKEDI 264
Query: 79 VAVKPTENNEE-------EFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKV 131
A++ E+ + +F KK + +KGKK+ + +E+E K+ + ++ + +
Sbjct: 265 NAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK----ERQEIE-KERRERERERERE 319
Query: 132 EMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESD 191
+ + + + +K K + ++ + D E + + +ER R S D +
Sbjct: 320 RERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNK 379
Query: 192 EFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK-RDEEKAKL 250
+ +SR+ + ++ + E E + +++ ++ERER++ R+ E+ +
Sbjct: 380 DRSRSREKSRDRERER-----ERERERE----------RERERERERERERERERERERE 424
Query: 251 RKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNE 310
R+ +K + E ++D ++++ +RK E+ + + I ++ E AE + E
Sbjct: 425 REKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEE 484
Query: 311 GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE 370
++ + K+ E E + + P A+Q+ L ++E E +R+ + + LE
Sbjct: 485 RRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELE 544
Query: 371 ELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQG 430
E+ + E + + ++ ++E ER+ + + + + ++ + E + E + +
Sbjct: 545 EIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEE 604
Query: 431 VEVPSKDSL-PKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPP 489
E K L P RPI + C + +P E +P
Sbjct: 605 EEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESP-CGII------IPH-ENSPDQ 656
Query: 490 VEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDE--ES 547
+PEE L A S + V+ K+ ++ N E+E+ ++ + +
Sbjct: 657 QQPEEHRPKIGLSL-KLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPL 715
Query: 548 EEEEEEEGESEGSEGDEEDEK 568
+ E+++ ++G+ EE K
Sbjct: 716 DYGEDDKNATKGTVNTEEKRK 736
Score = 57.4 bits (137), Expect = 8e-08
Identities = 64/286 (22%), Positives = 123/286 (43%), Gaps = 44/286 (15%)
Query: 367 KRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARA-EATLKL 425
K L +++AK K + L++ K ++K R E + + + + + R + + +++
Sbjct: 156 KLLVKVDAKTKAQ--LDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEV 213
Query: 426 L---QAQGVEVPSK--DSLPKKRPIYEDKKRKK------------IPQQLESKEVSESME 468
L + + PS+ DS P+K+ KK KK IP L +KE ++E
Sbjct: 214 LIREYSSELNAPSQESDSHPRKK-----KKEKKEDIFRRFPVAPLIPYPLITKEDINAIE 268
Query: 469 LCAAV-EVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527
+ +++ + + + +T +E E+ + ++E +++E + E
Sbjct: 269 MEEDKRDLISREISKFRDTHKKLEEEKGK--------------KEKERQEIEKERRERE- 313
Query: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM 587
+E E E E E E + E E E+E+E E E + D ++D + D+ +E
Sbjct: 314 RERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRER 373
Query: 588 SSDSEYDSDDDRTK---EERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
SSD D R K ER ++ + R +R E + E+ R
Sbjct: 374 SSDRNKDRSRSREKSRDRERERERERERERERERERERERERERER 419
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.127 0.339
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,106,978
Number of Sequences: 37866
Number of extensions: 2762155
Number of successful extensions: 146888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1862
Number of HSP's successfully gapped in prelim test: 1701
Number of HSP's that attempted gapping in prelim test: 19110
Number of HSP's gapped (non-prelim): 37633
length of query: 1220
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1106
effective length of database: 13,930,794
effective search space: 15407458164
effective search space used: 15407458164
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.