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Search of human proteins with 83715968
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens]
(1079 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens] 2133 0.0
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 112 2e-24
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 96 1e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 95 4e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 95 4e-19
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 93 2e-18
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 93 2e-18
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 90 1e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 90 1e-17
gi|221219020 NYD-SP11 protein [Homo sapiens] 88 4e-17
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 88 4e-17
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 88 4e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 87 6e-17
gi|71061468 centromere protein E [Homo sapiens] 87 8e-17
gi|33946313 ninein isoform 4 [Homo sapiens] 87 1e-16
gi|33946321 ninein isoform 5 [Homo sapiens] 87 1e-16
gi|148536871 ninein isoform 1 [Homo sapiens] 87 1e-16
gi|148536869 ninein isoform 2 [Homo sapiens] 87 1e-16
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 87 1e-16
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 86 2e-16
gi|38044112 restin isoform b [Homo sapiens] 86 2e-16
gi|4506751 restin isoform a [Homo sapiens] 86 2e-16
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 86 2e-16
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 85 3e-16
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 85 4e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 84 5e-16
gi|55770834 centromere protein F [Homo sapiens] 84 7e-16
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 83 1e-15
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 83 2e-15
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 83 2e-15
>gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens]
Length = 1079
Score = 2133 bits (5528), Expect = 0.0
Identities = 1079/1079 (100%), Positives = 1079/1079 (100%)
Query: 1 MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIV 60
MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIV
Sbjct: 1 MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIV 60
Query: 61 ETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIE 120
ETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIE
Sbjct: 61 ETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIE 120
Query: 121 GLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKE 180
GLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKE
Sbjct: 121 GLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKE 180
Query: 181 NHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENI 240
NHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENI
Sbjct: 181 NHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENI 240
Query: 241 NLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTE 300
NLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTE
Sbjct: 241 NLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTE 300
Query: 301 MEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINK 360
MEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINK
Sbjct: 301 MEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINK 360
Query: 361 IKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKY 420
IKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKY
Sbjct: 361 IKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKY 420
Query: 421 NTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDEN 480
NTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDEN
Sbjct: 421 NTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDEN 480
Query: 481 QSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVV 540
QSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVV
Sbjct: 481 QSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVV 540
Query: 541 LDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEP 600
LDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEP
Sbjct: 541 LDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEP 600
Query: 601 FKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQC 660
FKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQC
Sbjct: 601 FKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQC 660
Query: 661 KIKQIQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSK 720
KIKQIQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSK
Sbjct: 661 KIKQIQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSK 720
Query: 721 LLLKNSDKNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLN 780
LLLKNSDKNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLN
Sbjct: 721 LLLKNSDKNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLN 780
Query: 781 NENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLL 840
NENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLL
Sbjct: 781 NENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLL 840
Query: 841 NNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPV 900
NNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPV
Sbjct: 841 NNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPV 900
Query: 901 YMNFSDPGPWSKVNHIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVG 960
YMNFSDPGPWSKVNHIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVG
Sbjct: 901 YMNFSDPGPWSKVNHIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVG 960
Query: 961 KDIGPDTTSINRVADTLNNWSIHPDPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTP 1020
KDIGPDTTSINRVADTLNNWSIHPDPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTP
Sbjct: 961 KDIGPDTTSINRVADTLNNWSIHPDPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTP 1020
Query: 1021 LQSHLQAIKTTKNTSGDDDWQSLITNQLNKSENLLSLENDNQPKKRKAEETLEKNNRLK 1079
LQSHLQAIKTTKNTSGDDDWQSLITNQLNKSENLLSLENDNQPKKRKAEETLEKNNRLK
Sbjct: 1021 LQSHLQAIKTTKNTSGDDDWQSLITNQLNKSENLLSLENDNQPKKRKAEETLEKNNRLK 1079
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 112 bits (280), Expect = 2e-24
Identities = 167/743 (22%), Positives = 302/743 (40%), Gaps = 122/743 (16%)
Query: 31 KTSLLEALEELRMR----REAEIHYEEQIGKIIVETQELKWQ------KETLQNQKETLA 80
K LL+ +E+L+ + ++ ++ E +I + + + W KETL ++E L
Sbjct: 573 KRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILE 632
Query: 81 EQHKEAMAVFK---------KQLQMKMCALEEEKGKYQLATEIKEKEIEG-LKETLKALQ 130
E + +A+FK ++ +CA + E + E+K +I+ L +T L
Sbjct: 633 ENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELI 692
Query: 131 VSKYSLQKKVSEMEQKVQ------LHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEK 184
+K L+K+ +E + +Q ++ + K+L I +F +K + E
Sbjct: 693 KTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMEN 752
Query: 185 L-----EQNVREAIQSNKRLS----ALNKKQEAEICSLKKELK-----------KAASDL 224
+ + I +NK + + K +++ICS +K + K S
Sbjct: 753 TFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIH 812
Query: 225 IKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISF 284
+ S +T K EE + + + LQE I E+ + +EEK ++
Sbjct: 813 VSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQI 872
Query: 285 QHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL 344
H QQ L + N + E++ ++ N + +Q+ K +E EEK + L NE E A
Sbjct: 873 VHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETA- 931
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNEN 404
I N +S +K H K+ E +T + + N+ +N +
Sbjct: 932 -------------TRSITNNVSQIKLMHTKIDE-------LRTLDSVSQISNIDLLNLRD 971
Query: 405 SEMSTEKSE--NT---------IIQKYNTEQEIREENMEN-FCSDTE--YRE-----KEE 445
+E+ NT ++ K E I+E N EN F S E + E K
Sbjct: 972 LSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKAS 1031
Query: 446 KKEGSFIEEI--IIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTS 503
K+ IEE+ I+ LQ K +K+E + + ++ + L + +L +++ + Q
Sbjct: 1032 SKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEK 1091
Query: 504 NVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLD---V 560
NVT + + + E G T +K+ L+T +ET+K+ + L+ +
Sbjct: 1092 NVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKE---LETILETQKVECSHSAKLEQDIL 1148
Query: 561 HHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHAL----E 616
+ L++E N F L ++ NT N K++ E Q +H L E
Sbjct: 1149 EKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEE 1208
Query: 617 KEITNSDQT-----------------KADL----DSSLDIKKNPVPCQKY--SLRNSSNV 653
+E TN +T KADL + D+K+ +K ++ +V
Sbjct: 1209 EEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSV 1268
Query: 654 MLD-DKQCKIKQIQLLTKKSECS 675
M D DK +IK +L KK++CS
Sbjct: 1269 MRDEDKLLRIKINELEKKKNQCS 1291
Score = 77.4 bits (189), Expect = 7e-14
Identities = 140/690 (20%), Positives = 282/690 (40%), Gaps = 58/690 (8%)
Query: 31 KTSLLEALEELRMRREAEIH-YEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAV 89
K+ +E LE+ + +AE+ Y+++ ++ + +E K Q + L+ +KETL +Q KE +
Sbjct: 1034 KSHQIEELEQQIEKLQAEVKGYKDENNRL--KEKEHKNQDDLLK-EKETLIQQLKEELQE 1090
Query: 90 FKKQLQMKMCALEEEKGKYQLATE------IKEKEIEGLKETLKALQVSKYSLQKKVSEM 143
L +++ + E K T+ K KE+E + ET K L++ + E
Sbjct: 1091 KNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEK 1150
Query: 144 EQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALN 203
E + +++ + L + K + + +KE +L N +Q K L L
Sbjct: 1151 ESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNN----LQDMKHLLQLK 1206
Query: 204 KKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELN 263
+++E + ++E +K +L S Q + L KE+ + +L+E+L +
Sbjct: 1207 EEEEE---TNRQETEKLKEELSASSARTQNLKAD----LQRKEEDYADLKEKLTDAKKQI 1259
Query: 264 EKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKE--NNQTLERDNEL 321
+++ +E++ +++E + + I +++ Q Q + ++ LKE NNQ +E +
Sbjct: 1260 KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQ 1319
Query: 322 Q---------REKVKENEEKFLNLQN----EHEKALGTWKRHAEELNGEINKIKNELSSL 368
+EK+ E+ L Q E ++ L E L E+ K K + + L
Sbjct: 1320 YERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1379
Query: 369 --KETHIKLQEHYNK--LCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQ 424
K +EH N + + T +D+ ++ + N + + EK +I + +
Sbjct: 1380 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKM--MLITQAKEAE 1437
Query: 425 EIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEI 484
IR + M+ + D E K++ + ++ D L + ++ E D +V+ E Q +
Sbjct: 1438 NIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDL--QKWREERDQLVAALEIQLKA 1495
Query: 485 SLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTA 544
+S + D E+ + + T ++ +IK K D + + + F +
Sbjct: 1496 LISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNK 1555
Query: 545 IETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQF 604
IE + L+ + + F + + V+ P +
Sbjct: 1556 IEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARK 1615
Query: 605 RLLPGTREHALEKEITNSDQTKADL------DSSLDIKKNPVPCQKYSLRNSSNVMLD-D 657
R E ++ E + + +L D + +KK QK ++R SS
Sbjct: 1616 RKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKE----QKVAIRPSSKKTYSLR 1671
Query: 658 KQCKIKQIQLLTKKSECSILLSKQTSDFLQ 687
Q I + L TKK E ++ ++ DFLQ
Sbjct: 1672 SQASIIGVNLATKKKEGTL---QKFGDFLQ 1698
Score = 59.3 bits (142), Expect = 2e-08
Identities = 113/557 (20%), Positives = 226/557 (40%), Gaps = 60/557 (10%)
Query: 185 LEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEE------ 238
L++++ + ++ NK ++ +++ ++ L ++LKK + K K+T ++K+ EE
Sbjct: 553 LDEDLDKTLEENKAF--ISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFT 610
Query: 239 ----NINLTIKEQKFQE---LQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQ--- 288
KE QE L+E L + + + + +E +DI + +
Sbjct: 611 QYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEAT 670
Query: 289 ---QLLRQQIQAN-TEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL 344
+L QI+A + + EL KE + E +++ ++++ + +K + QN+ K L
Sbjct: 671 ACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIIT-QNQRIKEL 729
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKLQEH----YNKLCNQKTFEEDK-------- 392
E+ E +K+ + + + + K NKL +T E K
Sbjct: 730 INIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICS 789
Query: 393 KFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFI 452
+ + V E + E +K + +Q+ EE N + R +E EG
Sbjct: 790 ERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRA 849
Query: 453 EEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVT----DN 508
+ I++ EK K E++ + + + +S K L+L KEV ++
Sbjct: 850 FLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHV 909
Query: 509 RKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLE 568
+KS E ++KI + T +S N+ + I+ ++ R LD N++
Sbjct: 910 QKSKNQEQEEKIMKLSNEIETATRSITNNV----SQIKLMHTKIDELRTLDSVSQISNID 965
Query: 569 VENNKTSFNSILNETAHNTYHN-NNKDVSENEPFKQFRLLPGTREHALE----------K 617
+ N + N + NT + D ++ K++R+ RE++ K
Sbjct: 966 LLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECK 1025
Query: 618 EITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQLLTKKSECSIL 677
EI + K+ L+ + + + ++ +N L +K+ K Q LL +K
Sbjct: 1026 EIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENN-RLKEKEHK-NQDDLLKEKE----T 1079
Query: 678 LSKQTSDFLQVCNDTLE 694
L +Q + LQ N TL+
Sbjct: 1080 LIQQLKEELQEKNVTLD 1096
Score = 58.2 bits (139), Expect = 4e-08
Identities = 81/399 (20%), Positives = 170/399 (42%), Gaps = 51/399 (12%)
Query: 27 LLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEA 86
L +F+ L ++++ + E+ +E+I ++ Q++K + + ++ET +++
Sbjct: 1161 LKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET----NRQE 1216
Query: 87 MAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQK 146
K++L + K Q KE++ LKE L + +QK+VS M +
Sbjct: 1217 TEKLKEELSASSARTQNLKADLQR----KEEDYADLKEKLTDAKKQIKQVQKEVSVMRDE 1272
Query: 147 VQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLE-----QNVREAIQSNKRLSA 201
+L + +++E+EK + + + + ++L+ Q V EAIQ +R
Sbjct: 1273 DKLLRI-------KINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACK 1325
Query: 202 LNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQEL--------Q 253
+E I ++ L++ ++ + K+ EE L + +K++E
Sbjct: 1326 DLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKL-EEVERLATELEKWKEKCNDLETKNN 1384
Query: 254 ERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQ 313
+R N E E N + ++T++Q+E Q+ Q+ A+ + E K++ Q
Sbjct: 1385 QRSNKEHENNTDVLGKLTNLQDELQE-----------SEQKYNADRKKWLEEKMML-ITQ 1432
Query: 314 TLERDNELQRE--KVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKET 371
E +N +E K E+ E+F QNE E E + ++ K + E L
Sbjct: 1433 AKEAENIRNKEMKKYAEDRERFFKQQNEME----ILTAQLTEKDSDLQKWREERDQL--- 1485
Query: 372 HIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTE 410
+ E K ++D + + + + +E S++ T+
Sbjct: 1486 -VAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQ 1523
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 96.3 bits (238), Expect = 1e-19
Identities = 168/799 (21%), Positives = 326/799 (40%), Gaps = 131/799 (16%)
Query: 2 ESNFNTESSSTFTLQSSSETLFSIQLLDFK----------TSLLEALEELRMRREAEIHY 51
E+ E +T S E F+ ++L+ S LE ++ ++ E+H
Sbjct: 978 EAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR 1037
Query: 52 EEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEE-------- 103
E I + ++L Q E LQ E ++ ++ +A K+++ + C EE
Sbjct: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
Query: 104 -EKGKYQ------LATEIKEKEIE---------GLKETLKALQVS-KYSLQKKVSEMEQK 146
E+G Q L ++K+K LK L+ L+V SL++ EQ
Sbjct: 1098 KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 147 VQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQ 206
V+L +LA+ED K +SE+ T +F +K +HEK +++ + K+LS
Sbjct: 1158 VELKMLAEEDKRK-VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE-ELAI 1215
Query: 207 EAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIK-----EQKFQELQERLNMELE 261
+ +IC K E L+++K + N + + + +++E L ++
Sbjct: 1216 QLDICCKKTEA------LLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
Query: 262 LNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNEL 321
++ ++ + EE+ + ISFQ L ++ M+A+++ L + L+++
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329
Query: 322 QREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK 381
Q++ E E L+ +EL+ IN + LKE +++ +
Sbjct: 1330 QQQAASEKESCITQLK--------------KELSENINAVTLMKEELKEKKVEISSLSKQ 1375
Query: 382 LCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQ-EIREENME-NFCSDTE 439
L + ++ N S E + +++ ++Y+ E+ E+ ++ + +F DT
Sbjct: 1376 LTDLNV-----------QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424
Query: 440 YREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQ-SEISLSKTLSLDKEVIS 498
+EK E +DD +K + + +Q +N E+ + L KE
Sbjct: 1425 SKEKISALEQ-------VDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK-SKEAYE 1476
Query: 499 QGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETE-KIHLERTRG 557
+ + N+ ++ + + K CL+ E + + ++ +ETE K R
Sbjct: 1477 KDEQINLL--KEELDQQNKRFDCLK-----GEMEDDKSKMEKKESNLETELKSQTARIME 1529
Query: 558 LDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENE---PFKQFRLLPGTREH- 613
L+ H T +E+E+ LNE N +N KD+ E + F+ L +++
Sbjct: 1530 LEDHITQKTIEIES--------LNEVLKN--YNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 614 ---ALEKEITNSDQT---KADLDS----------SLDIKKNPVPCQKYSLRNSSNVMLDD 657
A EK +T +Q KA+L++ S+ K+ + + L + S L +
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639
Query: 658 KQCKIKQ------IQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVS 711
+ K +Q QLL++ E K T L N L++ E V +++ +
Sbjct: 1640 LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVH---ILEEKLK 1696
Query: 712 YAAFSANSKLLLKNSDKNV 730
S + L++ S KNV
Sbjct: 1697 SVESSQSETLIVPRSAKNV 1715
Score = 94.0 bits (232), Expect = 7e-19
Identities = 183/829 (22%), Positives = 328/829 (39%), Gaps = 131/829 (15%)
Query: 63 QELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGL 122
QEL+ K+ +K L Q ++A + ++ Q K + E K + E+KE+EI L
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 123 KETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENH 182
+ +K + L+ EQK + A E+ K LS +K +E
Sbjct: 388 RSRIKQMTTQGEELR------EQKEKSERAAFEELEKALSTAQK-----------TEEAR 430
Query: 183 EKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINL 242
KL+ + E I++ + K E E SL++EL + ++ V K EE I
Sbjct: 431 RKLKAEMDEQIKT------IEKTSEEERISLQQELSRVKQEV----VDVMKKSSEEQI-- 478
Query: 243 TIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEME 302
K QK E +E E EL +K+ QE+ + + Q + Q+
Sbjct: 479 -AKLQKLHE-KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE-------- 528
Query: 303 AELKVLKENNQTLERDN-ELQREKV-KENEEKFLNLQNEHEKALGTWKRHAEELNGEINK 360
KE ++L + ELQ++ + E+E K +LQ E E T++ EL + K
Sbjct: 529 ------KEQQESLALEELELQKKAILTESENKLRDLQQEAE----TYRTRILELESSLEK 578
Query: 361 -IKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQK 419
++ + K+ + L+ NK + T +K + + ++ + TEK + + Q+
Sbjct: 579 SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQ-VLKQQ 637
Query: 420 YNTEQEIREENMENFCSDTEYREK-EEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQD 478
Y TE E + REK E++KE ++ II + E + K T+ D
Sbjct: 638 YQTEME-------------KLREKCEQEKETLLKDKEIIFQAHIEEMNEK----TLEKLD 680
Query: 479 ENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHF 538
Q+E+ SL E+ + + + SV + DK+ E + E K N+H
Sbjct: 681 VKQTELE-----SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK--NHHQ 733
Query: 539 VVLDTAIETEKIHLERT---------------RGLDVHHTDVNLEVEN------------ 571
+D+ I+ ++ ++RT + D H + VEN
Sbjct: 734 QQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGEL 793
Query: 572 NKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLP-GTREHALEKEITNSDQTKADLD 630
+ S + ++ + H K E Q +LL T L K++ + K D+
Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853
Query: 631 SSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQI-QLLTKKSECSILLSKQTSDFLQVC 689
+ LD K V L ++ M + K+K + Q+ K E +QT L
Sbjct: 854 TELDAHKIQVQDLMQQLEKQNSEM----EQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
Query: 690 NDTL------EKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKPNSSP 743
+ + +K E+ + + S + + KN +K + VK +
Sbjct: 910 ENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEK----VKQKAKE 965
Query: 744 GGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHASQAKDVKTAVHMKTCTE 803
+T+ K + D + LENT + +S N+ + +A +
Sbjct: 966 MQETLKKKLLDQEAKLKKE----LENTALELSQKE-KQFNAKMLEMAQANSAGISDAVSR 1020
Query: 804 TEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNTEKTESLNDI 852
E +N+K QI+ +TE + +L +SI E++ L E+ + +++I
Sbjct: 1021 LE-TNQKEQIE--SLTEVHRRELNDVISIWEKK--LNQQAEELQEIHEI 1064
Score = 91.7 bits (226), Expect = 3e-18
Identities = 192/905 (21%), Positives = 369/905 (40%), Gaps = 152/905 (16%)
Query: 31 KTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVF 90
K S E + +L+ E E+ +EQ ++T+E ++Q++ K L + E + +
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ----MKVALEKSQSEYLKIS 526
Query: 91 KKQLQMKMCALEE-EKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQL 149
+++ Q + ALEE E K + TE + K L+ LQ + + ++ E+E ++
Sbjct: 527 QEKEQQESLALEELELQKKAILTESENK--------LRDLQQEAETYRTRILELESSLEK 578
Query: 150 HLLAKEDYHKQLS-----EIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNK 204
L ++ K L+ E K+ IT K E L+ ++A+ + K L L +
Sbjct: 579 SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ-QDALWTEK-LQVLKQ 636
Query: 205 KQEAEICSLKKELKKAASDLIKSK-VTCQYKMGEENIN----LTIKEQKFQELQERLNME 259
+ + E+ L+++ ++ L+K K + Q + E N L +K+ + + L L+
Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696
Query: 260 LELNEKINEEITHIQEE----KQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTL 315
L+ K+ EE++ ++++ KQ++ + +QQ+ + ++KE+ ++
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS---------IIKEHEVSI 747
Query: 316 ERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNEL---------- 365
+R + ++++ + E L E +K L + H E L +I + + EL
Sbjct: 748 QRTEKALKDQINQLEL----LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVF 803
Query: 366 -SSLKETHIKLQEHYNKLCN--QKTFEEDKK----FQNVPEVNNENSEMSTEKSENTI-- 416
S TH + + + +L QK + + + + V EV + ++ TE + I
Sbjct: 804 QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV 863
Query: 417 ------IQKYNTEQEIREENMEN-FCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKN 469
++K N+E E + +++ + S E KE+++ + E LQ+ E K
Sbjct: 864 QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ-KK 922
Query: 470 EIDTVVSQDENQSEISLS----------KTLSLDKEVISQGQTSNVTDNRKSVTTEIKDK 519
EI+ +++Q + E S+ K E + Q + + + K + + K
Sbjct: 923 EIE-ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ-KAKEMQETLKKKLLDQEAK 980
Query: 520 ICLEKDNGCTEFKSPNNHFV-------------VLDTAIETEKIHLERTRGL-DVHHTDV 565
+ E +N E F + D E E+ L +VH ++
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL 1040
Query: 566 NLEVENNKTSFNSILNETAHNTYHNNNKDVSENEP----FKQFRLLPGTREHALEKEITN 621
N + + + LN+ A + + E E KQ LL G + + KEIT
Sbjct: 1041 NDVI----SIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096
Query: 622 SDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQL---LTKKSECSILL 678
+ D++L+ + + K + +++ D+ + K +L L K + + L
Sbjct: 1097 LKEEGVKQDTTLNELQEQL---KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 679 SKQTSDFLQVCNDTLEK-SELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSM-SML 736
+Q + + + K SELT SKL K +D+ S+ S
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELT-------------------SKL--KTTDEEFQSLKSSH 1192
Query: 737 VKPNSSPGGKTM-CKNMSDMQNSQFNNCLGYLE-------NTNVNISHLHLNNENSHASQ 788
K N S K++ K +S+ Q + C E N +NIS N S S
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 789 AKD----VKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNTE 844
+ VK A+ +KTCT +E + Q+ E Q T L +S + H L
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT--------LNISFQQATHQLEEKEN 1304
Query: 845 KTESL 849
+ +S+
Sbjct: 1305 QIKSM 1309
Score = 91.3 bits (225), Expect = 4e-18
Identities = 142/608 (23%), Positives = 271/608 (44%), Gaps = 54/608 (8%)
Query: 15 LQSSSETLFSIQLLDFKTSLLEALEE---------LRMRREAEIHYEEQIGKIIVETQEL 65
L + +T QL D K +L+E LE+ R E EE+I ++ +++
Sbjct: 336 LHMAEKTKLITQLRDAK-NLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
Query: 66 KWQKETLQNQKE----TLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEG 121
Q E L+ QKE E+ ++A++ +K + + E + + + E+E
Sbjct: 395 TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERIS 454
Query: 122 LKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQF------ 175
L++ L ++ + KK SE EQ +L L +++ ++ E+ K T +F
Sbjct: 455 LQQELSRVKQEVVDVMKKSSE-EQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKV 513
Query: 176 GLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKM 235
L K E L+ + + Q + L L +++A + + +L+ DL + T + ++
Sbjct: 514 ALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLR----DLQQEAETYRTRI 569
Query: 236 --GEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQ----- 288
E ++ +++E K Q +++E E N K N+EIT + E+ + + S +H Q
Sbjct: 570 LELESSLEKSLQENKNQSKDLAVHLEAEKN-KHNKEITVMVEKHKTELESLKHQQDALWT 628
Query: 289 ---QLLRQQIQANTEMEAELKVLKENNQTLERDNE-LQREKVKENEEKFLNLQNEHEKAL 344
Q+L+QQ Q TEME + ++ +TL +D E + + ++E EK L + + L
Sbjct: 629 EKLQVLKQQYQ--TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL 686
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKL-QEHYNKLCNQKTFEEDKKFQNVPEVNNE 403
+ E+ +K++ ELS LK+ K+ QE K+ QK + + + E +E
Sbjct: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKE--HE 744
Query: 404 NSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLF 463
S TEK+ I + + R+++++ + E E + K+ +++ L +F
Sbjct: 745 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA-KLDVF 803
Query: 464 EKSFKNEIDTVVSQDENQSEISLSKTLSLDKE-VISQGQTSNVTDNRKSVTTEI-KDKI- 520
+ S+++ E Q K L L+ E ++ Q + V +K V TE+ KI
Sbjct: 804 Q-SYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQ 862
Query: 521 ------CLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKT 574
LEK N E K + V ++ +E E+T+ + V ++ L++ +
Sbjct: 863 VQDLMQQLEKQNSEMEQK-VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK 921
Query: 575 SFNSILNE 582
IL +
Sbjct: 922 KEIEILTQ 929
Score = 68.6 bits (166), Expect = 3e-11
Identities = 116/566 (20%), Positives = 228/566 (40%), Gaps = 78/566 (13%)
Query: 31 KTSLLEALEEL--RMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMA 88
K LL +EE + ++ E H E K+ QE + + L+ + +++ E +
Sbjct: 1652 KKQLLSQMEEKEEQYKKGTESHLSELNTKL----QEREREVHILEEKLKSVESSQSETLI 1707
Query: 89 VFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQ 148
V + + +EE + E++I L+ L + LQ+ E E+ V
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE---KEKLLQRVGQEKEETVS 1764
Query: 149 LHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSAL-----N 203
H + Y ++L ++E A ++ E+LE+ NK+ S +
Sbjct: 1765 SHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK-------NKKYSLIVAQHVE 1817
Query: 204 KKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELN 263
K+ K+ L+ D+ K+ + E+ + I EQK +EL L + E++
Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKT-------LQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 264 EKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQR 323
EE+T E+ Q + QQ+ + ++L+EN + + + +Q
Sbjct: 1871 RVEMEELTSKYEKLQAL------------QQMDGRNK---PTELLEENTEEKSKSHLVQP 1915
Query: 324 EKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLC 383
+ + E + N+ E L +R ++L EI +++ +L L++ H + E K
Sbjct: 1916 KLLSNMEAQ----HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971
Query: 384 NQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDT----- 438
+Q+ E+ K+ Q E+ E+ + +++++NT+ +E+ +E +T
Sbjct: 1972 DQEREEKIKQEQ-------EDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQ 2024
Query: 439 ----EYREKEEKKEGSFIEEII--IDDLQLFEKSFKNEID------TVVSQDENQSEISL 486
E E +++ +++I DDL+ K ++ +D T +D L
Sbjct: 2025 EVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEEL 2084
Query: 487 SKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIE 546
K E NVT + T++ K L D+ E + + D +
Sbjct: 2085 QKKYQQKLEQEENPGNDNVT--IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142
Query: 547 TEKIHLERT-----RGLDVHHTDVNL 567
EK T +G +++HTDV+L
Sbjct: 2143 YEKNVYATTVGTPYKGGNLYHTDVSL 2168
Score = 55.5 bits (132), Expect = 3e-07
Identities = 87/422 (20%), Positives = 164/422 (38%), Gaps = 39/422 (9%)
Query: 247 QKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQ---ANTEMEA 303
++ EL+E L M+ + + + EE EEK I Q LL+Q+++ N ++
Sbjct: 187 RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK 246
Query: 304 ELKVLKENNQ--TLERDNELQREKVKENEEKFLNLQ------NEHEKALGTWKRHAEELN 355
L L+ + T E + E E V E+ L+ E L K +
Sbjct: 247 PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHK 306
Query: 356 GEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKS--- 412
+ + +E +L+E + + K+ + E+ K + + N ++ +K
Sbjct: 307 EQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI 366
Query: 413 -------ENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEI--IIDDLQLF 463
T+ K ++R + E RE++EK E + EE+ + Q
Sbjct: 367 AETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT 426
Query: 464 E---KSFKNEIDTVVSQDENQSE---ISLSKTLS-LDKEVISQGQTSNVTDNRKSVTTEI 516
E + K E+D + E SE ISL + LS + +EV+ + S ++ + + ++
Sbjct: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS--SEEQIAKLQKL 484
Query: 517 KDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSF 576
+K K+ T+ + EK E + +L +E +
Sbjct: 485 HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK 544
Query: 577 NSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIK 636
+IL E+ N +D+ + + R+L E +LEK + + DL L+ +
Sbjct: 545 KAILTES-----ENKLRDLQQEAETYRTRIL--ELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 637 KN 638
KN
Sbjct: 598 KN 599
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 94.7 bits (234), Expect = 4e-19
Identities = 150/736 (20%), Positives = 307/736 (41%), Gaps = 107/736 (14%)
Query: 1 MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIV 60
+E N ES +++ + L + +L K L + LE L+ + E + +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 61 ETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLAT---EIKEK 117
E Q L+ +TL+N + + + E + L+M+ L++ + ++++ E EK
Sbjct: 764 ENQRLQ---KTLENSNKKIQQLESEL-----QDLEMENQTLQKNLEELKISSKRLEQLEK 815
Query: 118 EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGL 177
E + L++ L+ K L+K+ + Q+ ++ E+ + ++ +EK T++ + G+
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 178 VKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGE 237
KE+ +L++ +E KEL K A+ IK+ VT + E
Sbjct: 876 YKESCVRLKELEKE----------------------NKELVKRATIDIKTLVT----LRE 909
Query: 238 ENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISF--QHMQQLLRQQI 295
+ ++ +K Q+ E+L ELE E + H ++ D ++ L++ +
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969
Query: 296 QANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGT--------- 346
+ E A L+ E + + + + VK+N E Q+E +
Sbjct: 970 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1029
Query: 347 WKRHAEELNGEINKIKNELSSLK-------------ETHIKLQEHYNKLCNQKTFEEDKK 393
W+R ++E E+ K+K+ L ++ +T +K E N + ++
Sbjct: 1030 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 394 FQNVPEVN----NENS----EMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEE 445
++ E N +N+ E ST S++T + N + I++ ++EN +++ +E+E+
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE-NESVIKERED 1148
Query: 446 KKEGSFIEEIIID--DLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTS 503
K S + +I D L+L + +E ++++S+ S K L ++ +
Sbjct: 1149 LK--SLYDSLIKDHEKLELLHERQASEYESLISKHGTLK--SAHKNLEVEHRDLE--DRY 1202
Query: 504 NVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHT 563
N +K +++ + +E++ E K NH V A E +K+ E R ++HT
Sbjct: 1203 NQLLKQKGQLEDLEKMLKVEQEKMLLENK---NHETV---AAEYKKLCGENDR---LNHT 1253
Query: 564 DVNLEVENNKTSFNSILNET-AHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNS 622
++ +L ET T H N K + N +Q RL L+++
Sbjct: 1254 ------------YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL--EAEFSKLKEQYQQL 1299
Query: 623 DQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQ-LLTKKSECSILLSKQ 681
D T L++ ++ K +L + +LD Q + Q + LL + E L +
Sbjct: 1300 DITSTKLNNQCELLSQ----LKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1355
Query: 682 TSDFLQVCNDTLEKSE 697
++ N+ + E
Sbjct: 1356 QRQYIDKLNELRRQKE 1371
Score = 88.2 bits (217), Expect = 4e-17
Identities = 155/725 (21%), Positives = 314/725 (43%), Gaps = 73/725 (10%)
Query: 33 SLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQ----KETLAEQHKEAMA 88
SL + +EELR ++ +I K+ E Q L + E L+N+ K++L +
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530
Query: 89 VFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKAL-QVSKYSLQKKVSEMEQKV 147
+ K++ Q++ +E + + +I E+E E L +T+ +L Q S+ S + +V ++E++
Sbjct: 531 LMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 148 Q-LHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQ 206
+ LH KE K LS+IE I + KE E+ E+
Sbjct: 590 KILHESIKETSSK-LSKIEFEKRQIKKELEHYKEKGERAEE------------------L 630
Query: 207 EAEICSLKKELKKAASDLIKSKVTCQY--KMGEENINLTIKEQKFQELQE---RLNMELE 261
E E+ L+KE + + K+TC+ + +EN L + +K ++ + L +LE
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 262 LNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNEL 321
EK N ++ E + + S + + Q N E+E+E + LK+ + L+ +
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK- 749
Query: 322 QREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK 381
K + E + L E+++ T E N +I ++++EL L+ + LQ++ +
Sbjct: 750 ---KTERLEVSYQGLDIENQRLQKT----LENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 382 L-CNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQ-EIREENMENFCSDTE 439
L + K E+ +K + E S++ +K + K +Q EI++ +E
Sbjct: 803 LKISSKRLEQLEKENK--SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 440 YREKEEK---KEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEV 496
EKE K KE +E + L+ EK K + ++ I + ++L +++
Sbjct: 861 NLEKENKTLSKEIGIYKESCVR-LKELEKENKELV--------KRATIDIKTLVTLREDL 911
Query: 497 ISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNN-HFVVLDTAIETEKIHLERT 555
+S+ + +N T +KI L K+ + +S ++ + +L++ +E+
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 556 RGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNN--KDVSENEPFKQFRLLPGTREH 613
+ + + LE T++N L + N K + E Q ++
Sbjct: 972 KEEKIAALEARLE---ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1028
Query: 614 ALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCK--IKQIQLLTKK 671
E+E S +T +L L +K + + RN++ + + + K +KQ++
Sbjct: 1029 KWERE---SQETTREL---LKVKDRLIEVE----RNNATLQAEKQALKTQLKQLETQNNN 1078
Query: 672 SECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVH 731
+ IL ++ + LQ N TL+ + + + S + + N++LL++ S
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
Query: 732 SMSML 736
+ S++
Sbjct: 1139 NESVI 1143
Score = 63.5 bits (153), Expect = 1e-09
Identities = 96/428 (22%), Positives = 186/428 (43%), Gaps = 38/428 (8%)
Query: 14 TLQSSSETLFS-IQLLDFKTSLLEALEELRMRREAEIHYEE------QIGKIIVETQELK 66
TLQ+ + L + ++ L+ + + L+A + L ++R+ E+ Q K+ VE L
Sbjct: 1057 TLQAEKQALKTQLKQLETQNNNLQA-QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
Query: 67 WQKETLQNQKETLA------EQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIE 120
Q +L NQ L E E++ ++ L+ +L ++ K +L E + E E
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 121 GLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKE 180
L L+ + +L+ + ++E + L K QL ++EK + L +
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG----QLEDLEKMLKVEQEKMLLENK 1231
Query: 181 NHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENI 240
NHE + ++ N RL+ + E L+ + K S L SK+ Q ++ E
Sbjct: 1232 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE-QTRLEAEFS 1290
Query: 241 NLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTE 300
L + Q+ +LN + EL ++ +++EE + ++ Q + R ++ N E
Sbjct: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKG---NLEEENRHLLDQIQTLMLQNRTLLEQNME 1347
Query: 301 MEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHE----KALGTW----KRHAE 352
+ V E Q +++ NEL+R+K K EEK ++ ++ + G W R
Sbjct: 1348 SKDLFHV--EQRQYIDKLNELRRQKEK-LEEKIMDQYKFYDPSPPRRRGNWITLKMRKLI 1404
Query: 353 ELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKS 412
+ +IN+ + + +L T E + +L +Q + + N E + + T+KS
Sbjct: 1405 KSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLE---DGQTLGTKKS 1461
Query: 413 E--NTIIQ 418
N ++Q
Sbjct: 1462 STMNDLVQ 1469
Score = 61.6 bits (148), Expect = 4e-09
Identities = 135/662 (20%), Positives = 260/662 (39%), Gaps = 119/662 (17%)
Query: 194 QSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQY------KMGEENINLTIKEQ 247
+S + LS +A+I L++EL++ L+ K + ++ +EN+NL +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 248 KFQELQERLNMELELN---EKINEEITHIQEEKQDIIISFQHMQQL-------------L 291
+ ++ L+ E +K+ E++ +E DI +++L L
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 292 RQQIQANT-------EMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL 344
Q++ E+E E LK +E + ++ R+K++E E+ + L+ ++++
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNEN 404
+ L E+ +I + L N+L + + + E+ N++
Sbjct: 424 D----ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK--------LEMENQS 471
Query: 405 SEMSTEKSENTIIQKYNTEQEIREENMEN--FCSDTEYREKEEKKEGSFIE--EIIIDDL 460
+ E+ T+ +I + EN E E E +E ++ + + DL
Sbjct: 472 LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 461 QLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKI 520
+ + I+T+ E Q +I + L++ V S Q S + S +KD
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI-----SAEARVKD-- 584
Query: 521 CLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSIL 580
+EK+N H + +T+ + KI E+ + + E+E+ K
Sbjct: 585 -IEKENKIL-------HESIKETSSKLSKIEFEKRQ--------IKKELEHYKEKGERA- 627
Query: 581 NETAHNTYHNNNKDVSENEPF-KQFRLLPGTRE--HALEKEITNSDQTKADLDSSLDIKK 637
E N H+ K ENE K+ L T E ALE+E + ++ L +LD K
Sbjct: 628 -EELENELHHLEK---ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 638 NPVPCQKYSLRNSSNVMLDDK--------------QCKIKQIQLLTKKSECSILLSKQTS 683
N + Q SL N LD++ K+ Q+QL K+ E +Q
Sbjct: 684 N-LTFQLESL-EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE---KEQLK 738
Query: 684 DFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLL---LKNSDKNVHSMSMLVKPN 740
L++ + +K+E VSY ++ L L+NS+K + + ++ +
Sbjct: 739 KGLELLKASFKKTERL---------EVSYQGLDIENQRLQKTLENSNKKIQQLESELQ-D 788
Query: 741 SSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISH---------LHLNNENSHASQAKD 791
+T+ KN+ +++ S + L LE N ++ L EN Q +
Sbjct: 789 LEMENQTLQKNLEELKIS--SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 792 VK 793
+K
Sbjct: 847 IK 848
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 94.7 bits (234), Expect = 4e-19
Identities = 150/735 (20%), Positives = 308/735 (41%), Gaps = 106/735 (14%)
Query: 1 MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIV 60
+E N ES +++ + L + +L K L + LE L+ + E + +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 61 ETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLAT---EIKEK 117
E Q L+ +TL+N + + + E + L+M+ L++ + ++++ E EK
Sbjct: 764 ENQRLQ---KTLENSNKKIQQLESEL-----QDLEMENQTLQKNLEELKISSKRLEQLEK 815
Query: 118 EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGL 177
E + L++ L+ K L+K+ + Q+ ++ E+ + ++ +EK T++ + G+
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 178 VKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGE 237
KE+ +L++ +E KEL K A+ IK+ VT + E
Sbjct: 876 YKESCVRLKELEKE----------------------NKELVKRATIDIKTLVT----LRE 909
Query: 238 ENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQD-IIISFQHMQQLLRQQIQ 296
+ ++ +K Q+ E+L ELE E + H ++ D + ++ L++ ++
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE 969
Query: 297 ANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGT---------W 347
E A L+ E + + + + VK+N E Q+E + W
Sbjct: 970 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1029
Query: 348 KRHAEELNGEINKIKNELSSLK-------------ETHIKLQEHYNKLCNQKTFEEDKKF 394
+R ++E E+ K+K+ L ++ +T +K E N + ++
Sbjct: 1030 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089
Query: 395 QNVPEVN----NENS----EMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEK 446
++ E N +N+ E ST S++T + N + I++ ++EN +++ +E+E+
Sbjct: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE-NESVIKEREDL 1148
Query: 447 KEGSFIEEIIID--DLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSN 504
K S + +I D L+L + +E ++++S+ S K L ++ + N
Sbjct: 1149 K--SLYDSLIKDHEKLELLHERQASEYESLISKHGTLK--SAHKNLEVEHRDLE--DRYN 1202
Query: 505 VTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTD 564
+K +++ + +E++ E K NH V A E +K+ E R ++HT
Sbjct: 1203 QLLKQKGQLEDLEKMLKVEQEKMLLENK---NHETV---AAEYKKLCGENDR---LNHT- 1252
Query: 565 VNLEVENNKTSFNSILNET-AHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSD 623
++ +L ET T H N K + N +Q RL L+++ D
Sbjct: 1253 -----------YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL--EAEFSKLKEQYQQLD 1299
Query: 624 QTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQ-LLTKKSECSILLSKQT 682
T L++ ++ K +L + +LD Q + Q + LL + E L +
Sbjct: 1300 ITSTKLNNQCELLSQ----LKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQ 1355
Query: 683 SDFLQVCNDTLEKSE 697
++ N+ + E
Sbjct: 1356 RQYIDKLNELRRQKE 1370
Score = 92.8 bits (229), Expect = 2e-18
Identities = 155/724 (21%), Positives = 314/724 (43%), Gaps = 72/724 (9%)
Query: 33 SLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQ----KETLAEQHKEAMA 88
SL + +EELR ++ +I K+ E Q L + E L+N+ K++L +
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530
Query: 89 VFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKAL-QVSKYSLQKKVSEMEQKV 147
+ K++ Q++ +E + + +I E+E E L +T+ +L Q S+ S + +V ++E++
Sbjct: 531 LMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 148 Q-LHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQ 206
+ LH KE K LS+IE I + KE E+ E+
Sbjct: 590 KILHESIKETSSK-LSKIEFEKRQIKKELEHYKEKGERAEE------------------L 630
Query: 207 EAEICSLKKELKKAASDLIKSKVTCQY--KMGEENINLTIKEQKFQELQE---RLNMELE 261
E E+ L+KE + + K+TC+ + +EN L + +K ++ + L +LE
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 262 LNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNEL 321
EK N ++ E + + S + + Q N E+E+E + LK+ + L+ +
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK- 749
Query: 322 QREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK 381
K + E + L E+++ T E N +I ++++EL L+ + LQ++ +
Sbjct: 750 ---KTERLEVSYQGLDIENQRLQKT----LENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Query: 382 L-CNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQ-EIREENMENFCSDTE 439
L + K E+ +K + E S++ +K + K +Q EI++ +E
Sbjct: 803 LKISSKRLEQLEKENK--SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 440 YREKEEK---KEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEV 496
EKE K KE +E + L+ EK K + ++ I + ++L +++
Sbjct: 861 NLEKENKTLSKEIGIYKESCVR-LKELEKENKELV--------KRATIDIKTLVTLREDL 911
Query: 497 ISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTR 556
+S+ + +N T +KI L K+ + +S ++ + +L++ +E+ +
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 557 GLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNN--KDVSENEPFKQFRLLPGTREHA 614
+ + LE T++N L + N K + E Q ++
Sbjct: 972 EEKIAALEARLE---ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028
Query: 615 LEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCK--IKQIQLLTKKS 672
E+E S +T +L L +K + + RN++ + + + K +KQ++
Sbjct: 1029 WERE---SQETTREL---LKVKDRLIEVE----RNNATLQAEKQALKTQLKQLETQNNNL 1078
Query: 673 ECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHS 732
+ IL ++ + LQ N TL+ + + + S + + N++LL++ S +
Sbjct: 1079 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1138
Query: 733 MSML 736
S++
Sbjct: 1139 ESVI 1142
Score = 63.5 bits (153), Expect = 1e-09
Identities = 94/427 (22%), Positives = 185/427 (43%), Gaps = 36/427 (8%)
Query: 14 TLQSSSETLFS-IQLLDFKTSLLEALEELRMRREAEIHYEE------QIGKIIVETQELK 66
TLQ+ + L + ++ L+ + + L+A + L ++R+ E+ Q K+ VE L
Sbjct: 1056 TLQAEKQALKTQLKQLETQNNNLQA-QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1114
Query: 67 WQKETLQNQKETLA------EQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIE 120
Q +L NQ L E E++ ++ L+ +L ++ K +L E + E E
Sbjct: 1115 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174
Query: 121 GLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKE 180
L L+ + +L+ + ++E + L K QL ++EK + L +
Sbjct: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG----QLEDLEKMLKVEQEKMLLENK 1230
Query: 181 NHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENI 240
NHE + ++ N RL+ + E L+ + K S L SK+ Q ++ E
Sbjct: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE-QTRLEAEFS 1289
Query: 241 NLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTE 300
L + Q+ +LN + EL ++ +++EE + ++ Q + R ++ N E
Sbjct: 1290 KLKEQYQQLDITSTKLNNQCELLSQLKG---NLEEENRHLLDQIQTLMLQNRTLLEQNME 1346
Query: 301 MEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHE----KALGTW----KRHAE 352
+ V E Q +++ NEL+R+K K EEK ++ ++ + G W R
Sbjct: 1347 SKDLFHV--EQRQYIDKLNELRRQKEK-LEEKIMDQYKFYDPSPPRRRGNWITLKMRKLI 1403
Query: 353 ELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKS 412
+ +IN+ + + +L T E + +L +Q + + N E + + T+KS
Sbjct: 1404 KSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLE---DGQTLGTKKS 1460
Query: 413 ENTIIQK 419
+++
Sbjct: 1461 SMVALKR 1467
Score = 61.6 bits (148), Expect = 4e-09
Identities = 135/662 (20%), Positives = 260/662 (39%), Gaps = 119/662 (17%)
Query: 194 QSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQY------KMGEENINLTIKEQ 247
+S + LS +A+I L++EL++ L+ K + ++ +EN+NL +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 248 KFQELQERLNMELELN---EKINEEITHIQEEKQDIIISFQHMQQL-------------L 291
+ ++ L+ E +K+ E++ +E DI +++L L
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 292 RQQIQANT-------EMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL 344
Q++ E+E E LK +E + ++ R+K++E E+ + L+ ++++
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNEN 404
+ L E+ +I + L N+L + + + E+ N++
Sbjct: 424 D----ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK--------LEMENQS 471
Query: 405 SEMSTEKSENTIIQKYNTEQEIREENMEN--FCSDTEYREKEEKKEGSFIE--EIIIDDL 460
+ E+ T+ +I + EN E E E +E ++ + + DL
Sbjct: 472 LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 461 QLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKI 520
+ + I+T+ E Q +I + L++ V S Q S + S +KD
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI-----SAEARVKD-- 584
Query: 521 CLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSIL 580
+EK+N H + +T+ + KI E+ + + E+E+ K
Sbjct: 585 -IEKENKIL-------HESIKETSSKLSKIEFEKRQ--------IKKELEHYKEKGERA- 627
Query: 581 NETAHNTYHNNNKDVSENEPF-KQFRLLPGTRE--HALEKEITNSDQTKADLDSSLDIKK 637
E N H+ K ENE K+ L T E ALE+E + ++ L +LD K
Sbjct: 628 -EELENELHHLEK---ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 638 NPVPCQKYSLRNSSNVMLDDK--------------QCKIKQIQLLTKKSECSILLSKQTS 683
N + Q SL N LD++ K+ Q+QL K+ E +Q
Sbjct: 684 N-LTFQLESL-EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE---KEQLK 738
Query: 684 DFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLL---LKNSDKNVHSMSMLVKPN 740
L++ + +K+E VSY ++ L L+NS+K + + ++ +
Sbjct: 739 KGLELLKASFKKTERL---------EVSYQGLDIENQRLQKTLENSNKKIQQLESELQ-D 788
Query: 741 SSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISH---------LHLNNENSHASQAKD 791
+T+ KN+ +++ S + L LE N ++ L EN Q +
Sbjct: 789 LEMENQTLQKNLEELKIS--SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 792 VK 793
+K
Sbjct: 847 IK 848
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 92.8 bits (229), Expect = 2e-18
Identities = 125/463 (26%), Positives = 211/463 (45%), Gaps = 65/463 (14%)
Query: 22 LFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAE 81
L +L + S L+ LE+ R + +E+ + V +ELK + + + NQ + E
Sbjct: 975 LLRAELQSLEQSHLKELEDTLQVRHIQ-EFEKVMTDHRVSLEELKKENQQIINQ---IQE 1030
Query: 82 QHKEAMAVFKKQLQ---MKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQK 138
H E + +KQLQ +K+ L + + K ++ +KE E + +K L+
Sbjct: 1031 SHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE---------- 1080
Query: 139 KVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVRE-----AI 193
S +QK L L +++ +EI K I ++N+E + + E I
Sbjct: 1081 --SRAQQKETLKSLLEQETENLRTEISKLNQKI-------QDNNENYQVGLAELRTLMTI 1131
Query: 194 QSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQ 253
+ ++ +S L + E E LK EL +KVT + E I +KEQ ELQ
Sbjct: 1132 EKDQCISELISRHEEESNILKAEL---------NKVTSLHNQAFE-IEKNLKEQII-ELQ 1180
Query: 254 ERLNMELELNEKINEEITHIQEEKQDIIIS--FQHMQQLLRQQIQANTEMEAELKVLK-E 310
+L+ EL E+ +E QEEK + II + Q+L+ Q Q ++ +L K E
Sbjct: 1181 SKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDE 1240
Query: 311 NNQTLERDNELQREKV-KENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSL- 368
QT ++ +L+RE V KE EK +L+N+ K + I+ + + SSL
Sbjct: 1241 AIQTALKEFKLEREVVEKELLEKVKHLENQIAK------------SPAIDSTRGDSSSLV 1288
Query: 369 KETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE 428
E KLQE K Q EE +K +N E+ N + + E+ N T +++R+
Sbjct: 1289 AELQEKLQEEKAKFLEQ--LEEQEKRKN-EEMQNVRTSLIAEQQTN--FNTVLTREKMRK 1343
Query: 429 ENMENFCSD-TEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNE 470
EN+ N SD + ++++++ IE + D +L E+ K E
Sbjct: 1344 ENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLE 1386
Score = 69.3 bits (168), Expect = 2e-11
Identities = 108/512 (21%), Positives = 219/512 (42%), Gaps = 78/512 (15%)
Query: 31 KTSLLEALEELRMRREAEI--HYEEQIGKIIVETQELKWQKETLQNQKETLAE--QHKE- 85
K SL L+E + + YE ++ +I ET+E + + + L+ + L E Q+K+
Sbjct: 852 KCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDN 911
Query: 86 AMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQ 145
A+ K + + +C E+ K I + +KE ++ ++ L+K E ++
Sbjct: 912 EFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDE 971
Query: 146 KVQL-----------HLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQ 194
K+QL HL ED Q+ I+++ +T ++E ++ +Q + + +
Sbjct: 972 KLQLLRAELQSLEQSHLKELED-TLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQE 1030
Query: 195 SNKRLSALNKKQEAEI-----------CSLKKE--LKKAASDLIK---------SKVTCQ 232
S+ + +KQ E+ C L+ E LK+A +D IK K T +
Sbjct: 1031 SHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLK 1090
Query: 233 YKMGEENINLTIK----EQKFQELQE---------RLNMELELNEKINEEITHIQEEKQD 279
+ +E NL + QK Q+ E R M +E ++ I+E I+ +EE
Sbjct: 1091 SLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNI 1150
Query: 280 IIISFQHMQQLLRQQIQANTEMEAEL----KVLKENNQTLERDNELQREKVKENEEKF-- 333
+ + L Q + ++ ++ L LER + EK+ + EEK+
Sbjct: 1151 LKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKD---EKITQQEEKYEA 1207
Query: 334 --LNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEED 391
NL+ + +K + + ++ E+L ++N K+E KL+ ++ ++ E+
Sbjct: 1208 IIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLE---REVVEKELLEKV 1264
Query: 392 KKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSF 451
K +N ++ + ST ++++ + QE +E F E +EK + +E
Sbjct: 1265 KHLEN--QIAKSPAIDSTRGDSSSLVAEL---QEKLQEEKAKFLEQLEEQEKRKNEEMQN 1319
Query: 452 IEEIIIDDLQLFEKSFKNEIDTVVSQDENQSE 483
+ +I + Q +TV+++++ + E
Sbjct: 1320 VRTSLIAEQQ-------TNFNTVLTREKMRKE 1344
Score = 54.3 bits (129), Expect = 6e-07
Identities = 92/458 (20%), Positives = 201/458 (43%), Gaps = 69/458 (15%)
Query: 187 QNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKE 246
+N+ E ++ + ++ L +K + E+ SLK E + LIK EEN E
Sbjct: 845 RNIIEKVKCSLEIT-LKEKHQKELLSLKNEYEGKLDGLIKET--------EEN------E 889
Query: 247 QKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELK 306
K ++L+ L E+ + + E ++ EK+ +I Q L + E+K
Sbjct: 890 NKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIK 949
Query: 307 VLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELS 366
LK++ RE V E+ +K L+++N+ + L ++ EL
Sbjct: 950 ELKQS-----------REIVLEDLKK-LHVENDEKLQL----------------LRAELQ 981
Query: 367 SLKETHIKLQEHYNKLCNQKTFEEDKKFQNV--PEVNNENSEM--STEKSENTIIQKYNT 422
SL+++H+K E ++ + + FE+ V E+ EN ++ ++S IIQ+
Sbjct: 982 SLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQE--K 1039
Query: 423 EQEIREENME-NFCSDTEYREKEEKKEGSFIEEIIIDDLQ-LFEKSFKNEIDTVVSQDEN 480
E++++E ++ + SDT + + E ++E D+++ L E+S + +T+ S E
Sbjct: 1040 EKQLQELKLKVSDLSDTRCKLEVELA----LKEAETDEIKILLEESRAQQKETLKSLLEQ 1095
Query: 481 QSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVV 540
++E ++ L++++ Q +N +N + E++ + +EKD +E S +
Sbjct: 1096 ETENLRTEISKLNQKI----QDNN--ENYQVGLAELRTLMTIEKDQCISELISRH----- 1144
Query: 541 LDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEP 600
+ K L + L ++ ++ S L+ ++ +++ E
Sbjct: 1145 -EEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQE- 1202
Query: 601 FKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKN 638
+++ + E +K +++ +Q + L L+ +K+
Sbjct: 1203 -EKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKD 1239
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 92.8 bits (229), Expect = 2e-18
Identities = 125/463 (26%), Positives = 211/463 (45%), Gaps = 65/463 (14%)
Query: 22 LFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAE 81
L +L + S L+ LE+ R + +E+ + V +ELK + + + NQ + E
Sbjct: 975 LLRAELQSLEQSHLKELEDTLQVRHIQ-EFEKVMTDHRVSLEELKKENQQIINQ---IQE 1030
Query: 82 QHKEAMAVFKKQLQ---MKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQK 138
H E + +KQLQ +K+ L + + K ++ +KE E + +K L+
Sbjct: 1031 SHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE---------- 1080
Query: 139 KVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVRE-----AI 193
S +QK L L +++ +EI K I ++N+E + + E I
Sbjct: 1081 --SRAQQKETLKSLLEQETENLRTEISKLNQKI-------QDNNENYQVGLAELRTLMTI 1131
Query: 194 QSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQ 253
+ ++ +S L + E E LK EL +KVT + E I +KEQ ELQ
Sbjct: 1132 EKDQCISELISRHEEESNILKAEL---------NKVTSLHNQAFE-IEKNLKEQII-ELQ 1180
Query: 254 ERLNMELELNEKINEEITHIQEEKQDIIIS--FQHMQQLLRQQIQANTEMEAELKVLK-E 310
+L+ EL E+ +E QEEK + II + Q+L+ Q Q ++ +L K E
Sbjct: 1181 SKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDE 1240
Query: 311 NNQTLERDNELQREKV-KENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSL- 368
QT ++ +L+RE V KE EK +L+N+ K + I+ + + SSL
Sbjct: 1241 AIQTALKEFKLEREVVEKELLEKVKHLENQIAK------------SPAIDSTRGDSSSLV 1288
Query: 369 KETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE 428
E KLQE K Q EE +K +N E+ N + + E+ N T +++R+
Sbjct: 1289 AELQEKLQEEKAKFLEQ--LEEQEKRKN-EEMQNVRTSLIAEQQTN--FNTVLTREKMRK 1343
Query: 429 ENMENFCSD-TEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNE 470
EN+ N SD + ++++++ IE + D +L E+ K E
Sbjct: 1344 ENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLE 1386
Score = 69.3 bits (168), Expect = 2e-11
Identities = 108/512 (21%), Positives = 219/512 (42%), Gaps = 78/512 (15%)
Query: 31 KTSLLEALEELRMRREAEI--HYEEQIGKIIVETQELKWQKETLQNQKETLAE--QHKE- 85
K SL L+E + + YE ++ +I ET+E + + + L+ + L E Q+K+
Sbjct: 852 KCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDN 911
Query: 86 AMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQ 145
A+ K + + +C E+ K I + +KE ++ ++ L+K E ++
Sbjct: 912 EFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDE 971
Query: 146 KVQL-----------HLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQ 194
K+QL HL ED Q+ I+++ +T ++E ++ +Q + + +
Sbjct: 972 KLQLLRAELQSLEQSHLKELED-TLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQE 1030
Query: 195 SNKRLSALNKKQEAEI-----------CSLKKE--LKKAASDLIK---------SKVTCQ 232
S+ + +KQ E+ C L+ E LK+A +D IK K T +
Sbjct: 1031 SHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLK 1090
Query: 233 YKMGEENINLTIK----EQKFQELQE---------RLNMELELNEKINEEITHIQEEKQD 279
+ +E NL + QK Q+ E R M +E ++ I+E I+ +EE
Sbjct: 1091 SLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNI 1150
Query: 280 IIISFQHMQQLLRQQIQANTEMEAEL----KVLKENNQTLERDNELQREKVKENEEKF-- 333
+ + L Q + ++ ++ L LER + EK+ + EEK+
Sbjct: 1151 LKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKD---EKITQQEEKYEA 1207
Query: 334 --LNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEED 391
NL+ + +K + + ++ E+L ++N K+E KL+ ++ ++ E+
Sbjct: 1208 IIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLE---REVVEKELLEKV 1264
Query: 392 KKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSF 451
K +N ++ + ST ++++ + QE +E F E +EK + +E
Sbjct: 1265 KHLEN--QIAKSPAIDSTRGDSSSLVAEL---QEKLQEEKAKFLEQLEEQEKRKNEEMQN 1319
Query: 452 IEEIIIDDLQLFEKSFKNEIDTVVSQDENQSE 483
+ +I + Q +TV+++++ + E
Sbjct: 1320 VRTSLIAEQQ-------TNFNTVLTREKMRKE 1344
Score = 54.3 bits (129), Expect = 6e-07
Identities = 92/458 (20%), Positives = 201/458 (43%), Gaps = 69/458 (15%)
Query: 187 QNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKE 246
+N+ E ++ + ++ L +K + E+ SLK E + LIK EEN E
Sbjct: 845 RNIIEKVKCSLEIT-LKEKHQKELLSLKNEYEGKLDGLIKET--------EEN------E 889
Query: 247 QKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELK 306
K ++L+ L E+ + + E ++ EK+ +I Q L + E+K
Sbjct: 890 NKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIK 949
Query: 307 VLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELS 366
LK++ RE V E+ +K L+++N+ + L ++ EL
Sbjct: 950 ELKQS-----------REIVLEDLKK-LHVENDEKLQL----------------LRAELQ 981
Query: 367 SLKETHIKLQEHYNKLCNQKTFEEDKKFQNV--PEVNNENSEM--STEKSENTIIQKYNT 422
SL+++H+K E ++ + + FE+ V E+ EN ++ ++S IIQ+
Sbjct: 982 SLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQE--K 1039
Query: 423 EQEIREENME-NFCSDTEYREKEEKKEGSFIEEIIIDDLQ-LFEKSFKNEIDTVVSQDEN 480
E++++E ++ + SDT + + E ++E D+++ L E+S + +T+ S E
Sbjct: 1040 EKQLQELKLKVSDLSDTRCKLEVELA----LKEAETDEIKILLEESRAQQKETLKSLLEQ 1095
Query: 481 QSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVV 540
++E ++ L++++ Q +N +N + E++ + +EKD +E S +
Sbjct: 1096 ETENLRTEISKLNQKI----QDNN--ENYQVGLAELRTLMTIEKDQCISELISRH----- 1144
Query: 541 LDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEP 600
+ K L + L ++ ++ S L+ ++ +++ E
Sbjct: 1145 -EEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQE- 1202
Query: 601 FKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKN 638
+++ + E +K +++ +Q + L L+ +K+
Sbjct: 1203 -EKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKD 1239
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 90.1 bits (222), Expect = 1e-17
Identities = 139/752 (18%), Positives = 312/752 (41%), Gaps = 92/752 (12%)
Query: 34 LLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQ 93
L ++EL+ R EI + E+ + Q + ++ +H+E ++ ++++
Sbjct: 214 LQNIIKELKQNRSQEIDDHQH---------EMSVLQNAHQQKLTEISRRHREELSDYEER 264
Query: 94 LQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLA 153
++ ++ L ++ G + T++ + I +++T++ LQ+ K KK+ ++E K++
Sbjct: 265 IE-ELENLLQQGGSGVIETDLSK--IYEMQKTIQVLQIEKVESTKKMEQLEDKIK----- 316
Query: 154 KEDYHKQLSEIEKYYATITG-QFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEA---- 208
D +K+LS E + Q L E + +E+ ++ +K + K+ +
Sbjct: 317 --DINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEK 374
Query: 209 -----------EICSLKKELKKAASDLIK-SKVTCQYKMGEENINLTIK----------- 245
E+ L++ L A +++++ S + + E+N+ L ++
Sbjct: 375 ERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLL 434
Query: 246 EQKFQELQE---RLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEME 302
Q+ +ELQ +LN E E+ + + E D+ ++ + +Q L Q I +
Sbjct: 435 SQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLI 494
Query: 303 AELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIK 362
AE++ L NQ + L ++++ + + + ++ ++ ++ L K+ +L + I
Sbjct: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
Query: 363 NELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNT 422
EL KE I+ + N L K EDK V N +++ + N IQK N
Sbjct: 555 KELDVQKEKLIQSEVALNDLHLTKQKLEDK-------VENLVDQLNKSQESNVSIQKENL 607
Query: 423 E--QEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDEN 480
E + IR+ E E + + S ++ ++ + + ++ K + + +EN
Sbjct: 608 ELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNEN 667
Query: 481 QSEISLSKTLSLDKEVIS------------------QGQTSNVTDNRKSVTTEIKDKICL 522
+++ + +K V++ + + + + K EI+ ++C
Sbjct: 668 LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCW 727
Query: 523 EKDNGCTEFKSPNNHFVVLDTA--IETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSIL 580
K E L A + T + LE + ++ ++E+ K + +
Sbjct: 728 AKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK-DMEIAELKKNIEQM- 785
Query: 581 NETAHNTYHNNNKDV--SENEPFKQFRLLPGTREHALEKEITNSDQTKADLDS-SLDIKK 637
+T H KDV S E KQ L +E +EK S + + +LD S ++K
Sbjct: 786 -----DTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
Query: 638 NPVPCQKYSLRNSSNVMLDDKQCKIKQ--IQLLTKKSECSILLSKQTSDFL-QVCNDTLE 694
N + Q ++ S + ++ +++ +L ++S + + +T D + ++ ++ +
Sbjct: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ 900
Query: 695 KSELTVPCDIVIDHHVSYAAFSANSKLLLKNS 726
+ + + I HH SK+ L S
Sbjct: 901 LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
Score = 73.6 bits (179), Expect = 1e-12
Identities = 154/821 (18%), Positives = 324/821 (39%), Gaps = 152/821 (18%)
Query: 31 KTSLLEALEELRMRREAEIHYEEQIGK-----IIVETQELKWQKETLQNQKETLAEQHKE 85
K LL++L+E + + + EQ+ + + +E+K ++T++ K L E+ ++
Sbjct: 926 KMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD 985
Query: 86 AMA----VFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKET---LKALQVSKYSLQK 138
+F+ + +++ +E K+ L+ E+ ++G+KE +K L SL K
Sbjct: 986 IQTDNSDIFQ-ETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTK 1044
Query: 139 KVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITG------------QFGLVKENHEKLE 186
++ ++ K ++ L + K L EI+ +A I+ Q EK+
Sbjct: 1045 QIDQLS-KDEVGKLTQIIQQKDL-EIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVF 1102
Query: 187 QNVREAIQSNKRLSALNKK-------QEAEICSLKKELKKAAS-------DLIKSKVTCQ 232
+ E + N L K +EA + L+ E KK ++ D+ + +
Sbjct: 1103 AVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNL 1162
Query: 233 YKM-GEENINLTIKEQKFQELQERLNME-----------------LELNEKINEEITHIQ 274
++ E++I + QK Q L L L+ +K+ +++ ++
Sbjct: 1163 SRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKME 1222
Query: 275 EEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFL 334
E KQ ++ + Q+MQ Q + +++A++ V +NN L+ D + ++NE K
Sbjct: 1223 EWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLK 1282
Query: 335 NLQNE---HEKALGTWKRHAEELNGEINKIKNELSS-------------------LKETH 372
N E + ++G + L G+++ I +LSS L E+
Sbjct: 1283 NFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
Query: 373 IKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENME 432
LQ+ +L + E+D + + E N+ S+ SE + T+ EI+
Sbjct: 1343 ELLQQELEEL-RKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK----- 1396
Query: 433 NFCSDTEYREKEE-----KKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLS 487
+ +EK++ KE + + D L ++F N++ N++E+
Sbjct: 1397 ------QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV--------NENELLRQ 1442
Query: 488 KTLSLDKEVI--------SQGQTSNVTDNRKSVTTEIK---------DKICLEKDNGCTE 530
+L + ++ +G+ + + + TE + + EK+ C
Sbjct: 1443 AVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS 1502
Query: 531 FKSPNNHFVVLDTAIETEKIHLERTRG------------LDVHHTDVNLEVENNKTSFNS 578
K + A+ E++ E+ +G + V + E ++ +
Sbjct: 1503 MK---------EKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVML-A 1552
Query: 579 ILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKN 638
+ + NT N ++ F+ + L R H LE E + + + A D ++K
Sbjct: 1553 LKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKK 1612
Query: 639 PVPCQKYSLRNSSNVMLDDKQCKIKQIQLLTKKSECSILLSKQTSDFLQVCNDTLEKSEL 698
V + L +SSN M + Q++ L ++ +T+ L V + +++ L
Sbjct: 1613 -VTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYAL 1671
Query: 699 TVP-CDIVIDH-----HVSYAAFSANSKLLLKNSDKNVHSM 733
++ +V++H Y+A K L+ KN ++
Sbjct: 1672 SLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL 1712
Score = 67.0 bits (162), Expect = 9e-11
Identities = 120/593 (20%), Positives = 242/593 (40%), Gaps = 81/593 (13%)
Query: 4 NFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQ 63
+ N +S+S F E ++ L S LE L E + ++ E + K+++ +
Sbjct: 630 SLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENE--KLVLACE 687
Query: 64 ELKWQKET-------LQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEI-- 114
+++ Q E L +K T+ E K + +L L EE KY+ E
Sbjct: 688 DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELS 747
Query: 115 -----------------------KEKEIEGLKETLKALQV----SKYSLQKKVSEMEQKV 147
K+ EI LK+ ++ + +K L + E +Q
Sbjct: 748 NARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLT 807
Query: 148 QLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQE 207
QL + KE + ++L E ++ +E L Q + E +S + N +
Sbjct: 808 QL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ 866
Query: 208 AEICSLKKELKKAASDLIKSKVTCQYKMGEENINL-TIKEQKFQELQERLNMELELNEKI 266
E+ L++E + A + ++ E L TIKE +E++ + + N+
Sbjct: 867 EELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSK 926
Query: 267 NEEITHIQEEKQDI-IISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREK 325
+ + +QE+K+++ +QH +Q+ Q E + E+K L++ + ++ +R+
Sbjct: 927 MQLLQSLQEQKKEMDEFRYQH-EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD 985
Query: 326 V--------KENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQE 377
+ +E + + LN++N EK K E L I + + E+ L E +I L +
Sbjct: 986 IQTDNSDIFQETKVQSLNIENGSEKH-DLSKAETERLVKGIKERELEIKLLNEKNISLTK 1044
Query: 378 HYNKLCNQKTFEEDKKFQNVPEVNNENSEM-----STEKSENTI-----IQKYNTEQE-- 425
++L E K Q + + + E + ST +++ + +Q Y E+E
Sbjct: 1045 QIDQLSKD---EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKV 1101
Query: 426 ---IREENMENFCSDTEYREKEE---KKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQD- 478
+ E+ EN TEY + + KE + I+ + D+ + F++ + +
Sbjct: 1102 FAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK--LQDENKKLSTRFESSGQDMFRETI 1159
Query: 479 ENQSEISLSKTLSLD------KEVISQGQTSNVTDNRKSVTTEIKDKICLEKD 525
+N S I K + +D + +++ QTS+ + V + +++ E+D
Sbjct: 1160 QNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERD 1212
Score = 62.4 bits (150), Expect = 2e-09
Identities = 79/361 (21%), Positives = 158/361 (43%), Gaps = 47/361 (13%)
Query: 24 SIQLLDFKTSLLEALEELRMRREAEIHYEEQI-------GKI------IVET---QELKW 67
S QLL + + E + R+A + +E+I GK+ IVET +E ++
Sbjct: 1420 SDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEY 1479
Query: 68 Q--KETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK-------------YQLAT 112
Q +ET L E+ E ++ +K L + E+E+GK Q T
Sbjct: 1480 QALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKT 1539
Query: 113 EIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQK----------VQLHLLAKED-YHKQL 161
+ ++E + + LK Q+ +LQ +V + K ++ HLL ED Y ++
Sbjct: 1540 VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREA 1599
Query: 162 SEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAA 221
E A + + +++E KL + ++ + S + + ++ + K+ + A
Sbjct: 1600 LAAEDREAKLRKKVTVLEE---KLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
Query: 222 SDL-IKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDI 280
L + + QY + N+ + ++ + QE + + ELE +++ E E +
Sbjct: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQ-QEEKAMYSAELEKQKQLIAEWKKNAENLEGK 1715
Query: 281 IISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEH 340
+IS Q + + + + +L V +E + L+R NEL++E + + ++K ++L N
Sbjct: 1716 VISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSS 1775
Query: 341 E 341
E
Sbjct: 1776 E 1776
Score = 59.7 bits (143), Expect = 1e-08
Identities = 165/906 (18%), Positives = 357/906 (39%), Gaps = 153/906 (16%)
Query: 121 GLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQL-----SEIEKYYATITGQF 175
GL ++L + S SL ++S + + + E+ +L EIE +A + +
Sbjct: 11 GLGQSLGQVGGSLASLTGQISNFTKDMLME--GTEEVEAELPDSRTKEIEAIHAILRSEN 68
Query: 176 GLVK-------ENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSK 228
+K E HE E +++ QS + L +K E EI LK L+K +
Sbjct: 69 ERLKKLCTDLEEKHEASEIQIKQ--QSTSYRNQLQQK-EVEISHLKARQIALQDQLLKLQ 125
Query: 229 VTCQYKMGEENINLTIKEQKF---------------QELQERLNMELELNEKINEEITHI 273
Q + T F + + ++ + E+N +++ E++ +
Sbjct: 126 SAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN-RLSNEVSRL 184
Query: 274 QEEKQDIIISFQHMQQLLRQQIQANTEMEAELK---VLKENNQTLERDNELQREKVKENE 330
+ E + ++H+ Q + Q N++ K ++KE Q + +++ +++
Sbjct: 185 ESE----VGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQN-------RSQEIDDHQ 233
Query: 331 EKFLNLQNEHEKALGTW-KRHAEELNG---EINKIKNEL----SSLKETHI----KLQEH 378
+ LQN H++ L +RH EEL+ I +++N L S + ET + ++Q+
Sbjct: 234 HEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKT 293
Query: 379 YNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE-------ENM 431
L +K K Q ++ + N ++S+ +++ I+++ + + + EN+
Sbjct: 294 IQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENL 353
Query: 432 ENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLS 491
+ CS + ++ + E I+ + E+ F+ + +++E SL++ S
Sbjct: 354 KLECSKLQPSAVKQSDTMTEKERILAQSASV-EEVFRLQQALSDAENEIMRLSSLNQDNS 412
Query: 492 LDKEVISQGQTSNVTDNRKSVTTEIKDKI---CLEKDNGCTEFKSPNNHFVVLDTAIETE 548
L ++ + V + KS+ ++ K+++ L+ +N KS + LD+ +
Sbjct: 413 LAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDL 472
Query: 549 KIHLER-----TRGLDVHHTDV----NLEVENNKTSFNSILNETAHNTYHNNNKDV---- 595
+++LE + + T + L+ +N + + + IL + + N +
Sbjct: 473 RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
Query: 596 -------------SENEPFKQFRLLPGTREHALEKEITNSD--QTKADLDSSLD------ 634
E++ + L +E ++ E+ +D TK L+ ++
Sbjct: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
Query: 635 --IKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQL---------------LTKKSECSIL 677
+++ V QK +L ++ ++++ + +L L K+ E +
Sbjct: 593 NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVR 652
Query: 678 LSKQTSDFLQVCNDTLEK---------SELTVPCDIVIDHHVSYAAFSANSKLLLKNSDK 728
KQ L+ N+ L+K +L + C+ V H + N++L L +K
Sbjct: 653 NLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDV--RHQLEECLAGNNQLSL---EK 707
Query: 729 NVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENT-NVNISHLHLNNEN-SHA 786
N ++ ++ K + +++ + L N N+N S L L +E+
Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
Query: 787 SQAKDVKTAVHMKTCTETEFSNKKNQ-------IDENQVTEATKNDLFLFVSINERQHTL 839
+Q KD++ A K + + +K+ + ++ Q+T+ + ER L
Sbjct: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827
Query: 840 LNNTE-------KTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRS--TFDLST 890
+ K E L + K S G ++E ++ E L R+ D T
Sbjct: 828 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT 887
Query: 891 SDKKTE 896
D TE
Sbjct: 888 LDSVTE 893
Score = 54.7 bits (130), Expect = 5e-07
Identities = 91/477 (19%), Positives = 212/477 (44%), Gaps = 66/477 (13%)
Query: 68 QKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEE-EKGKYQLA------TEIKEKEIE 120
+ E L E L ++ +E +K LQ K + ++ ++L+ +E++ KE E
Sbjct: 1334 KSEVLSESSELLQQELEE----LRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHE 1389
Query: 121 GLKETLKALQVSKYSLQKKVSEMEQKVQLH----LLAKEDYHKQLSEIEKYYATITGQFG 176
+K L+ + LQK + E + ++ L + E++ +++E E +T
Sbjct: 1390 QTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTN--- 1446
Query: 177 LVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMG 236
+KE LE ++ + N+++ + +E E +L++ K + L + + C + M
Sbjct: 1447 -LKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC-HSMK 1504
Query: 237 EENINLT-IKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQI 295
E+ + + ++K Q LN L + + E+ Q+E+ ++++ L+Q+
Sbjct: 1505 EKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA-------LKQKQ 1557
Query: 296 QANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELN 355
NT ++ E++ L++ ++ E R + E+E+ + +AL R A
Sbjct: 1558 MENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTR------EALAAEDREA---- 1607
Query: 356 GEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNN--ENSEMSTEKSE 413
K++ +++ L+E KL + E+ Q +V + E + +++ +
Sbjct: 1608 ----KLRKKVTVLEE----------KLVSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
Query: 414 NTIIQKYNTEQEIREE--NMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEI 471
T +Q +++++++ ++ N E+ ++EEK S E + ++K+ +N
Sbjct: 1654 ETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLE 1713
Query: 472 DTVVSQDENQSEIS--------LSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKI 520
V+S E E + L++ L + +E I + + N + R+ + +++ K+
Sbjct: 1714 GKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQN--ELRQEMLDDVQKKL 1768
Score = 47.8 bits (112), Expect = 6e-05
Identities = 100/450 (22%), Positives = 182/450 (40%), Gaps = 72/450 (16%)
Query: 1 MESNFNTESSSTFTLQSSSETLFSI-QLLDFKTSLLEALEELRMRREAEIHYEEQIGKII 59
+E N + +T LQ E L + Q D + + EL+ E ++ ++
Sbjct: 743 IEELSNARNLNTSALQLEHEHLIKLNQKKDME------IAELKKNIEQMDTDHKETKDVL 796
Query: 60 VETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLA---TEIKE 116
+ E + Q L N+KE E+ KE + L+EE KY A EI
Sbjct: 797 SSSLEEQKQLTQLINKKEIFIEKLKE-----------RSSKLQEELDKYSQALRKNEILR 845
Query: 117 KEIEGLKETLKALQVSKYSLQKKVSEM-EQKVQLHLLAKEDYHKQLSEIEKYYATITGQF 175
+ IE +L +++ LQ+++ + E++ + +A ++E+ A+ Q
Sbjct: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTEL----ASEVSQL 901
Query: 176 GLVKENHEKLEQNVREAI--QSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQY 233
+KE+ E+ ++ ++ I Q+ ++ L QE KKE+ ++
Sbjct: 902 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQ-----KKEMD-------------EF 943
Query: 234 KMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQ 293
+ E +N T Q F E E + L + I + T + EE+QDI + Q +
Sbjct: 944 RYQHEQMNAT-HTQLFLEKDEEIK---SLQKTIEQIKTQLHEERQDIQTDNSDIFQETKV 999
Query: 294 QIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN---------EHEKAL 344
Q N E +E K + E + ++ K +E E K LN +N + +
Sbjct: 1000 Q-SLNIENGSE----KHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEV 1054
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETH--IKLQEHYNKLCNQKTFEEDKKFQNVPEVNN 402
G + ++ + EI + +SS T + LQ+ E +K F + E
Sbjct: 1055 GKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAY----AMEREKVFAVLNEKTR 1110
Query: 403 ENSEMSTE--KSENTIIQKYNTEQEIREEN 430
ENS + TE K + + K ++++EN
Sbjct: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDEN 1140
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 90.1 bits (222), Expect = 1e-17
Identities = 183/919 (19%), Positives = 376/919 (40%), Gaps = 119/919 (12%)
Query: 4 NFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQ 63
NFN + Q +++ + ++ D K+ +E R REA E+++ ++ T+
Sbjct: 151 NFNIKQMKDLFEQKAAQ--LATEIADIKSKY----DEERSLREAA---EQKVTRL---TE 198
Query: 64 ELKWQKETLQNQK-ETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGL 122
EL + +Q+ K E L E +AV KK+L ++ T +E+E E L
Sbjct: 199 ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDN-------MTLERERESEKL 251
Query: 123 KETLKALQVSKYSLQKKVSEME-------QKVQLHLLAKEDYHKQLSEIEKYYATITGQF 175
K+ K LQ S + +S++ Q+V +++ + ++E+ + T+T
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311
Query: 176 GLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKM 235
++++ KLE+ E S K + A +++ + L+ L + + L +
Sbjct: 312 LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI-------- 363
Query: 236 GEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQI 295
++ L+ K + Q+L+E L+ + + E +Q+++++ QH QL +
Sbjct: 364 ---HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE---KEQHGLQLQSEIN 417
Query: 296 QANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQ---NEHEKALGTWKRHAE 352
Q ++++ + L E + L+ +L EK+ + E++ +LQ + E+ L ++
Sbjct: 418 QLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNST 477
Query: 353 ELNGEINKIK---NELSSLKE-THIKLQEHYNKL--CNQKTFEEDKKFQNVP---EVNNE 403
EL +++K K E +L++ T KL+E N L ++ ++D+K QN+ + + E
Sbjct: 478 ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 537
Query: 404 NSEMSTEKSE----------------NTIIQKYNTEQEIREENMENFCSDTEYREKEEKK 447
N + ++ E N + +K +T QE + E + +E ++ ++
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Query: 448 EGSFIEE-----IIIDDLQLFEKSFKNEIDTVVSQDENQ-----SEISLSKTLSLDKEVI 497
++E D L ++ NE+++ +++ + + +I L L E
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 498 SQGQTSNVTDNRKSVTTEIKD------KICLEKDNGCTEFKSPNNHFVVLDTAIETEK-- 549
Q +++ ++ + ++D KI + D + + H L++ ++ K
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 550 -IHLE-RTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQF--- 604
+ LE +T L+ + + K S L + N + ++ E KQ
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 605 -------RLLPGTREHALE---KEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVM 654
RL + ALE +++T ++ K L + Q L N
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 655 LDDKQ-CKIKQIQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYA 713
+ + Q K+++ L+T+ S LSK SD L+ EK ++D +
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSK-VSDSLKNSKSEFEKENQKGKA-AILDLEKTCK 895
Query: 714 AFSANSKLLLKNSDKNVHSM-SMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNV 772
++ ++N+ K + L K + + N Q Q N L E
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 773 ----NISHLHLNNENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFL 828
NI+ L ++E Q + ++ + + +TE NK Q Q+T+A +
Sbjct: 956 QLQGNINELKQSSEQK-KKQIEALQGELKIAVLQKTELENKLQQ----QLTQAAQE---- 1006
Query: 829 FVSINERQHTLLNNTEKTE 847
+ E+ L NN EK++
Sbjct: 1007 LAAEKEKISVLQNNYEKSQ 1025
Score = 79.7 bits (195), Expect = 1e-14
Identities = 129/618 (20%), Positives = 270/618 (43%), Gaps = 88/618 (14%)
Query: 15 LQSSSETLFSIQL-LDFKTSLLEALEELRMRREAEI-HYEEQIGKIIVETQELKWQKETL 72
LQ + L I LD T+ L+ +E + E+ + Y+E+ + +T+EL+ Q + L
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 73 QNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVS 132
+ + ++A+ ++Q Q+ LE ATE+ K++E KE + + +
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNT-DLELR------ATELS-KQLEMEKEIVSS---T 784
Query: 133 KYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREA 192
+ LQKK +E Q L K++ KQ+ +++ + T++ + K HE+L ++
Sbjct: 785 RLDLQKKSEALESIKQK--LTKQEEEKQI--LKQDFETLSQE---TKIQHEELNNRIQTT 837
Query: 193 IQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKV------------------TCQYK 234
+ +++ + E+ ++K +L K + L SK TC+
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 235 MGEENINL--TIKEQKFQELQERLNMELELNEKINEEITHIQE--------------EKQ 278
+ + + T+KEQK EL++ L E E + ++ E+ +QE E+Q
Sbjct: 898 KHQLQVQMENTLKEQK--ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 279 DIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQRE------KVKENEEK 332
+ + ++Q Q+ + ++ ELK+ Q E +N+LQ++ ++ +EK
Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKIAVL--QKTELENKLQQQLTQAAQELAAEKEK 1013
Query: 333 FLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDK 392
LQN +EK+ T+K+ + G +++ LK KL + ++
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL-----------SLAQED 1062
Query: 393 KFQNVPEVNNENSEMSTEKSENTIIQKYNT--EQEIRE--ENMENFCSDTEYREKE---E 445
N ++ N+N + K+ +++ + EQ+++E + +++ + +EKE E
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 446 KKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNV 505
K + + IEEI + K + + + + + +K L + +++ QG+ ++
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 506 ---TDNRKSVTTEIKDKICLEKDNGCTEF--KSPNNHFVVLDTAIETEKIHLERTRGLDV 560
+ K +KD++ E++ EF K H + + + +K H E L +
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKK-HEENEAKLTM 1241
Query: 561 HHTDVNLEVENNKTSFNS 578
T +N + K + S
Sbjct: 1242 QITALNENLGTVKKEWQS 1259
Score = 70.5 bits (171), Expect = 8e-12
Identities = 98/392 (25%), Positives = 176/392 (44%), Gaps = 40/392 (10%)
Query: 1 MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIV 60
+++N+ +S TF S +LL + L E+L + +E I QIG
Sbjct: 1017 LQNNYE-KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK 1075
Query: 61 ETQELKWQKETLQN---QKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIK-- 115
QELK K TL+ +KE ++ +A+ +K+ +K L EK K EIK
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135
Query: 116 -EKEIEGLKETLKALQ---VSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATI 171
EKEI L E LK+ + + + + K ++ + +L L K D K E EK I
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195
Query: 172 TGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTC 231
VK+ E+L+ +E I+ +L + K++E +KK + A K+T
Sbjct: 1196 LKD--QVKKEEEELK---KEFIEKEAKLHSEIKEKEV---GMKKHEENEA------KLTM 1241
Query: 232 QYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLL 291
Q EN+ KE +Q Q R++ + + + EI ++ Q+ + + LL
Sbjct: 1242 QITALNENLGTVKKE--WQSSQRRVSELEKQTDDLRGEIAVLEATVQN---NQDERRALL 1296
Query: 292 RQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHA 351
+ ++ E+E + E + L+ +E +EN+ +LQ +H +AL ++ A
Sbjct: 1297 ERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQ----SLQIKHTQALN--RKWA 1350
Query: 352 EELNGEINKIKNELSSLKETHIKLQEHYNKLC 383
E+ N+++N ++ K + ++ H+ + C
Sbjct: 1351 ED-----NEVQNCMACGKGFSVTVRRHHCRQC 1377
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 88.2 bits (217), Expect = 4e-17
Identities = 107/506 (21%), Positives = 228/506 (45%), Gaps = 57/506 (11%)
Query: 30 FKTSLLEALEELRMRREAEIHYEEQIG----KIIVETQELKWQKETLQNQKETLAEQHKE 85
F L + E+L +E I +E++ K++ L ++E L +K LA + +
Sbjct: 1884 FNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALE--K 1941
Query: 86 AMAVFKKQLQMKMCALEEEKG---KYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSE 142
AM KK+L+ ++ +EEK + + E K + +EG KETL + + S Q+K+++
Sbjct: 1942 AMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG-KETLSKGETPETSRQRKMTQ 2000
Query: 143 MEQ-----------KVQLH---LLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQN 188
+EQ K+ LH +LA E+ SEI K T + + KL +
Sbjct: 2001 VEQELFERKLSLEEKILLHEDRILAMEE-----SEIAKGKLEFTRGQRIFVQGQRKLAKA 2055
Query: 189 VREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQK 248
R+ I+ + LS K+ A++ + K L+K D + K+ +E I +T ++
Sbjct: 2056 SRKLIKKRESLS----KEPAKLNKILKALQKLTRD--------ERKLTQEEIKMTKMKRA 2103
Query: 249 FQELQERLNME---LELNE-KINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAE 304
+ RL++E L++ E +E+ + + ++++ + + + +R+ I +M E
Sbjct: 2104 LFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEE 2163
Query: 305 LKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNE 364
L + + D+E + +E FL + K + E+ + +++++++E
Sbjct: 2164 ESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESE 2223
Query: 365 LSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQ 424
+E L E L Q++ +++ + E E E+ E+ E ++ +Q
Sbjct: 2224 EHFSEEMESLLDE----LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQ 2279
Query: 425 EIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEI 484
+EE + + +E+ ++KE F E+ E + E +++ ++E +
Sbjct: 2280 VEKEEEEKKKKKKEKKKEEVQEKEEVFEEK--------EEIMSEEETESLSDEEEEEESC 2331
Query: 485 SLSKTLSLDKEVISQGQTSNVTDNRK 510
SL + + +KE++ + + + + R+
Sbjct: 2332 SLEEEVDREKEILKKEKQFKLQEQRR 2357
Score = 72.8 bits (177), Expect = 2e-12
Identities = 109/468 (23%), Positives = 207/468 (44%), Gaps = 60/468 (12%)
Query: 38 LEELRMRREAEIHYEE-----QIGKIIVETQELKWQKETLQNQKETLAE----------- 81
+EEL + E E++ EE + K+ E + L WQ+E L ++ LA+
Sbjct: 1725 MEELSWKEE-ELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEK 1783
Query: 82 --QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKK 139
QHKE M +++L K L E+K K E +E L + L K Q+K
Sbjct: 1784 LAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEK 1843
Query: 140 VSEMEQKVQLHLLAKED--YHKQ-LSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSN 196
+ ++K +L KE+ Y+K+ L+ +K + + G+ K+ V E +
Sbjct: 1844 KNLAQEKEKL-AQRKENLLYNKERLTHSKKQLVQVKNKLGM----FNKILAQVEEKLTQE 1898
Query: 197 KRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERL 256
K + + KK+ ++ +K+L + L K Q K+ +E + L +++ Q ++RL
Sbjct: 1899 KE-TVIKKKE--KLAETEKKLVQVEDSLAKK----QEKLAQEKMKLALEKAMVQG-KKRL 1950
Query: 257 NMELEL---NEKINEEITHIQEEKQDII-----ISFQHMQQLLRQQIQANTEME------ 302
EL++ + +N E+ + EEK ++ +S + RQ+ E E
Sbjct: 1951 RGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKL 2010
Query: 303 -AELKVLKENNQTLE-RDNELQREKVKENEEKFLNLQNEHEKALGTWK--RHAEELNGE- 357
E K+L ++ L ++E+ + K++ + + +Q + + A + K + E L+ E
Sbjct: 2011 SLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEP 2070
Query: 358 --INKIKNELSSLKETHIKLQEHYNKLCNQK--TFEEDKKFQ-NVPEVNNENSEMSTEKS 412
+NKI L L KL + K+ K F ++++ +++ + + S ++S
Sbjct: 2071 AKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRS 2130
Query: 413 ENTIIQKYNTEQEIREEN-MENFCSDTEYREKEEKKEGSFIEEIIIDD 459
E T +K ++ + N M + E +EE K E+I+DD
Sbjct: 2131 ELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDD 2178
Score = 64.7 bits (156), Expect = 5e-10
Identities = 107/531 (20%), Positives = 214/531 (40%), Gaps = 61/531 (11%)
Query: 39 EELRMRREAEIHYEEQIGKIIVE-TQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
+E + + E E+ EE++ + E Q++ ++ +Q + + K A A K+ + +
Sbjct: 1534 KEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER 1593
Query: 98 MCALEEEK---GKYQLATEIKEKEIEGLKETLKALQVS---------KYSLQKKVSEMEQ 145
A EEEK + QLA E ++ +K T +++ + +L ++ ++ Q
Sbjct: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
Query: 146 KVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKK 205
+ + ++ K+ ++ + + + G + E L Q V E Q + L K+
Sbjct: 1654 EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKE 1713
Query: 206 QEAEICSL----------KKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQER 255
E+ L ++EL + L++ K K+ EE L + +K E + +
Sbjct: 1714 LAQELEELEWDMEELSWKEEELNQEEGKLVEEK----KKLAEEEEALAWQREKLSEEETK 1769
Query: 256 LNMELEL-----------NEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAE 304
L E EL EK+ EE + +++ +I + Q + I + E+
Sbjct: 1770 LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKN 1829
Query: 305 LKVLKENNQTLERDNELQREKVKENEEKFLNLQNEH-----EKALGTWKRHAEELNGEIN 359
+L + + L +EK K + K L N+ +K L K N +
Sbjct: 1830 KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILA 1889
Query: 360 KIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQK 419
+++ +L+ KET IK +E + + ED + ++ E +++ EK+ ++
Sbjct: 1890 QVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR 1949
Query: 420 YNTEQEIREE----NME---------NFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKS 466
E +I +E N+E E K E E S ++ + +LFE+
Sbjct: 1950 LRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERK 2009
Query: 467 FKNEIDTVVSQDE----NQSEISLSK-TLSLDKEVISQGQTSNVTDNRKSV 512
E ++ +D +SEI+ K + + + QGQ +RK +
Sbjct: 2010 LSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLI 2060
Score = 42.7 bits (99), Expect = 0.002
Identities = 75/386 (19%), Positives = 150/386 (38%), Gaps = 81/386 (20%)
Query: 57 KIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEI-- 114
K+ ++ + ++ L ++ LA + ++ ++ + + EEE + +E+
Sbjct: 2117 KLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVIL 2176
Query: 115 ---------KEKEIEGLKETLKALQVSKYS--LQKKVSEMEQKVQLHLLAKEDYHKQLSE 163
+E+ I LK + + +K ++K S +V+ E+ L E
Sbjct: 2177 DDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDE 2236
Query: 164 IEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASD 223
+EK + + + +E E+ E+ VRE + K +++E E +K+++K +
Sbjct: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERK------EEEEGE----EKQVEKEEEE 2286
Query: 224 LIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIIS 283
K K KE+K +E+QE+ EE+ EEK++I+
Sbjct: 2287 KKKKK----------------KEKKKEEVQEK------------EEVF---EEKEEIM-- 2313
Query: 284 FQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKA 343
+ E L +E ++ + E+ REK +EK LQ + K+
Sbjct: 2314 --------------SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKS 2359
Query: 344 LGTWKRHAEELNG---------EINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKF 394
L +R L G + +K+ L L T ++++E +K + K
Sbjct: 2360 LRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKK 2419
Query: 395 QNVPEVNNENSEMSTEKSENTIIQKY 420
V E+ + T E ++ KY
Sbjct: 2420 ATVVEI--PRKFLGTMDKEREVMGKY 2443
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 88.2 bits (217), Expect = 4e-17
Identities = 96/460 (20%), Positives = 214/460 (46%), Gaps = 35/460 (7%)
Query: 39 EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKM 98
+E +M R+ E EQ GK+ + ++++ Q++ L+ Q++ L EQ KE K + Q +
Sbjct: 253 QEEKMWRQEE-RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQ 311
Query: 99 CALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYH 158
+EEK ++ +++E+E E + + + +K++ E EQK++ +
Sbjct: 312 MQEQEEK-MWEQEEKMREQE-----EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 365
Query: 159 KQLSEIEKYYATITGQFGLVKENHEK-----LEQNVREAIQSNKRLSALNKKQEAEICSL 213
++L E E+ + ++ E+ E+ +RE ++ + +KQE +
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425
Query: 214 K-KELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELEL--NEKINEEI 270
+ KE ++ K K+ Q KM E+ + +E+K ++ +E E ++ EK+ E+
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 485
Query: 271 THIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENE 330
+ E+++ + Q M + + + + + + ++E + +++ +++ EK + +
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545
Query: 331 EKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ--KTF 388
EK ++ EK R E + K++ E ++E K+QE K+ Q K +
Sbjct: 546 EK--KTWDQEEKM-----REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598
Query: 389 EEDKKFQNVPEVNNENSEMSTEKSENTIIQK-----YNTEQEIREENMENFCSDTEYREK 443
E+++K Q E E E E+ E +Q+ + E++++E+ + + + + RE+
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 444 EEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSE 483
EEK + +Q E+ + + + + Q+E E
Sbjct: 659 EEKMREQ------EEKMQGQEEKMREQEEKMQGQEEKMRE 692
Score = 77.4 bits (189), Expect = 7e-14
Identities = 94/473 (19%), Positives = 208/473 (43%), Gaps = 75/473 (15%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
+EEL R+A ++ + + +ELK + LQ +K LAE K + + K+L+ K
Sbjct: 161 IEELTKERDA---LSLELYRNTITNEELKKKNAELQ-EKLRLAESEKSEIQLNVKELKRK 216
Query: 98 M------------CALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQ 145
+ L+EE + + +EK+I +E + + + K+ E E+
Sbjct: 217 LERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE 276
Query: 146 KVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNK- 204
K++ + K+L E EK + Q L ++ + EQ + Q K K
Sbjct: 277 KMRRQEKRLREQEKELREQEK---ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333
Query: 205 -KQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELN 263
+QE + +K++++ + KM ++ + ++++ +E +ER+ +
Sbjct: 334 WRQEERLWEQEKQMREQ-----------EQKMRDQEERMWEQDERLREKEERMREQ---- 378
Query: 264 EKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQR 323
EK+ E+ +QEE++ + ++ +R++ + E E +++ +E N + + E Q+
Sbjct: 379 EKMWEQEEKMQEEER-----IREREKKMREEEETMREQEEKMQ-KQEENMWEQEEKEWQQ 432
Query: 324 EKVKENEEKFLNLQNEHEKALGTWK-----RHAEELNGE------INKIKNELSSLKETH 372
+++ E +EK + E+ W+ R EE+ G+ K++ + + E
Sbjct: 433 QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 492
Query: 373 IKLQEHYNKLCNQ--KTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREEN 430
K+++ K+ +Q + +E+D++ + E E +M ++ +K E++ +E+
Sbjct: 493 EKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE------EKMREEKKTQEQE 546
Query: 431 MENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSE 483
+ + + + RE+E +E EK + E + + Q+E E
Sbjct: 547 KKTWDQEEKMREEERMRER--------------EKKMREEEEMMREQEEKMQE 585
Score = 75.1 bits (183), Expect = 3e-13
Identities = 96/405 (23%), Positives = 182/405 (44%), Gaps = 58/405 (14%)
Query: 40 ELRMRREAEI--HYEEQIGKI---IVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQL 94
E +MR E E EE++ K + E +E +WQ++ L QKE L EQ K Q
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK-------MQE 450
Query: 95 QMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAK 154
Q + +EEK + Q +EK++ +E ++ + + ++K+ + EQK+
Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKM-WRQEKMREQEDQMWEQEEKMRDQEQKMW------ 503
Query: 155 EDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLK 214
D +++ E ++ ++E E++ + ++ Q +++ K QE E +
Sbjct: 504 -DQEERMWEQDER----------LREKEERMREQ-KKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 215 KELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQ 274
+E K + ++ + + KM EE + +E+K QE +E++ E EK+ E Q
Sbjct: 552 QEEKMREEERMRER---EKKMREEEEMMREQEEKMQEQEEKMR---EQEEKMWE-----Q 600
Query: 275 EEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFL 334
EEK Q ++ + +Q + E E E K+ ++ E Q EK++E EEK
Sbjct: 601 EEKM------QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWE-----QEEKMQEQEEKMW 649
Query: 335 NLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ--KTFEEDK 392
+ + + + E++ G+ K++ + ++ K++E K+ Q K + +++
Sbjct: 650 EQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Query: 393 KFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSD 437
K E EM EK E QK ++ + E E CS+
Sbjct: 710 KMWGQEEKMWGQEEM-REKEERIRDQKEKMQERLPEH--EERCSE 751
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/308 (23%), Positives = 136/308 (44%), Gaps = 21/308 (6%)
Query: 36 EALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQ 95
E L E +E E EQ KI QE W +E ++E + EQ + +K
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKI--RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Query: 96 MKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKE 155
+ ++E+ ++ ++EKE E ++E K Q + ++K ++ ++K K
Sbjct: 498 QEQKMWDQEERMWEQDERLREKE-ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 156 DYHKQLSEIEKYYATITGQFGLVKENHEKL-EQNVREAIQSNKRLSALNKKQEAEICSLK 214
+++ E EK + + +++E EK+ EQ + Q K K QE E +
Sbjct: 557 REEERMREREK---KMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 215 KELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQ 274
+E K + + KM E+ + +E+K QE +E++ E EK+ E+ ++
Sbjct: 614 QEEKMWEQEE-------EDKMQEQEEMMWEQEEKMQEQEEKM---WEQEEKMREQEEKMR 663
Query: 275 EEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFL 334
E+++ + Q ++ +R+Q + E +++ +E + E Q EK+ EEK
Sbjct: 664 EQEEKM----QGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMW 719
Query: 335 NLQNEHEK 342
+ EK
Sbjct: 720 GQEEMREK 727
Score = 57.8 bits (138), Expect = 6e-08
Identities = 84/404 (20%), Positives = 159/404 (39%), Gaps = 78/404 (19%)
Query: 102 EEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQL 161
E+EK E +EIE T++ L K L+ L +D ++
Sbjct: 70 EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETA-----------LYYSQDAARKF 118
Query: 162 SEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALN---KKQEAEICSLKKELK 218
+ G G K+ +L + A + + LSA++ KK + I L KE
Sbjct: 119 ED---------GNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERD 169
Query: 219 KAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQ 278
+ +L ++ +T N +K+ K ELQE+L + +I + ++ + +
Sbjct: 170 ALSLELYRNTIT----------NEELKK-KNAELQEKLRLAESEKSEIQLNVKELKRKLE 218
Query: 279 DIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
+ L Q+Q NT L+E E + Q +K+++ EEK +
Sbjct: 219 --------RAKFLLPQVQTNT--------LQEEMWRQEEELREQEKKIRKQEEKMWRQEE 262
Query: 339 EHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVP 398
+ G + E++ + +++ + L+E +L+E +K E++++ Q
Sbjct: 263 RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE------QKKLREQEEQMQEQE 316
Query: 399 EVNNENSEMSTEKSENTIIQK----------YNTEQEIREENMENFCSDTEYREKEEK-- 446
E E E E+ E Q+ EQ++R++ + D REKEE+
Sbjct: 317 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376
Query: 447 -------KEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSE 483
+E EE + ++ EK + E +T+ Q+E +
Sbjct: 377 EQEKMWEQEEKMQEE---ERIREREKKMREEEETMREQEEKMQK 417
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 88.2 bits (217), Expect = 4e-17
Identities = 152/749 (20%), Positives = 322/749 (42%), Gaps = 92/749 (12%)
Query: 14 TLQSSSETL-FSIQ-LLDFKTSLLEALEELRMRREAE-IHYEEQIGKIIVETQELKWQKE 70
+L SS E+L +++ L + K L++ +E L+ + AE ++E+ ++ E + L E
Sbjct: 1564 SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYE 1623
Query: 71 TLQNQKETLAEQHK-EAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKAL 129
+ N+ E + QH EA+ K++L K+ + E K + + + E+E+E +KE ++
Sbjct: 1624 NVSNEAERI--QHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF 1681
Query: 130 QVSKYSLQKKVSEMEQ-----KVQLH-------------LLAKEDYHKQLSEIEKYYATI 171
SK Q+K+ E+E+ + ++H L + ++L ++ Y T+
Sbjct: 1682 AKSK---QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETL 1738
Query: 172 TGQFGLVKENHEKLEQNVREA-------IQSNKRLSALNKKQ------EAEICSLKKELK 218
+ +F + + L + V++ + L A K E S+ E +
Sbjct: 1739 SKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETE 1798
Query: 219 KAASDLIKSKVTCQYKM-GEENINLTIKE------------QKFQELQERLNMELELNEK 265
+ S + ++ TC + ++ N + + Q+ +L+ER+ E +K
Sbjct: 1799 EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQK 1858
Query: 266 INEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREK 325
E ++ EK ++ L+ + T+M + ++E + + E E+
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 326 VKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ 385
+ EE+ +N E ++G + + + + +++E+ +LK+ +L+E +L +
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978
Query: 386 KTFEED-------KKFQNVPEVNNENS------EMSTEKSENT-IIQKYNTEQEIREENM 431
KT E +K Q + S E+ EK + +QK + + +
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISAL 2038
Query: 432 ENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEIS--LSKT 489
E E+ + E +K+ +E + ++ +K+ V D+ QSE + L+
Sbjct: 2039 ERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN 2098
Query: 490 LSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEK 549
L L KE+ S ++ +K E + + EK K N LD A+ EK
Sbjct: 2099 LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK-----HLKEKKNMQEKLD-ALRREK 2152
Query: 550 IHLERTRG-LDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLP 608
+HLE T G + V + EV+ + + +S + + A T K +S + + R++
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT-----KSMSSLQDDRD-RVID 2206
Query: 609 GTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQI--- 665
++ E++ +++ Q+K + + +K++ K LR S + +++ + I ++
Sbjct: 2207 EAKK--WERKFSDAIQSK---EEEIRLKEDNCSVLKDQLRQMS-IHMEELKINISRLEHD 2260
Query: 666 -QLLTKKSECSILLSKQTSDFLQVCNDTL 693
Q+ K++ + L ++ D LQ N L
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGENKEL 2289
Score = 80.9 bits (198), Expect = 6e-15
Identities = 110/520 (21%), Positives = 217/520 (41%), Gaps = 67/520 (12%)
Query: 35 LEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQL 94
L+A EL R EI+ +EQ KII L ++E +Q L +QH + + K+L
Sbjct: 2363 LQASRELTSRLHEEINMKEQ--KII---SLLSGKEEAIQVAIAELRQQHDKEI----KEL 2413
Query: 95 QMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAK 154
+ + EEE + + + L ETLK + K ++QK QL
Sbjct: 2414 ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI---------KKENIQQKAQL----- 2459
Query: 155 EDYHKQLSEIEKYYATITGQFGLVKENHEKL----EQNVREAIQSNKRLSALNKKQEAEI 210
+ + K +S ++ I G + ++E H + +Q ++EA N +L + + +
Sbjct: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
Query: 211 CSLKKELKKAASDLIKSK------VTCQYKMGEENINLTIK-----EQKFQELQERLNME 259
L E K ++LI+ + +T + ++ + + ++ E K+ +L+E+L
Sbjct: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKES 2579
Query: 260 LELNEKINEEITHIQEEKQDIIISFQHMQ----QLLRQQIQANTE-----MEAELKVLKE 310
E NE + +QEEKQD+ + ++ QL RQ E A+LKV +E
Sbjct: 2580 EEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEE 2639
Query: 311 NNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKE 370
L ++++ E EE+ + +Q E K +G + ++L E+ + ++ ++
Sbjct: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE---DKLKKELKHLHHDAGIMRN 2696
Query: 371 THIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREEN 430
+E +L E K V EN ++ + IQ + + +
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLM----VTKENKGLTAQ------IQSFGRSMSSLQNS 2746
Query: 431 MENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTL 490
++ ++ E E + K + S E + + L + + + E SLS
Sbjct: 2747 RDH--ANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLE 2804
Query: 491 SLDKEVISQGQ-----TSNVTDNRKSVTTEIKDKICLEKD 525
L+++++S+ + +S + D+ V + K L+ +
Sbjct: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE 2844
Score = 76.6 bits (187), Expect = 1e-13
Identities = 102/484 (21%), Positives = 211/484 (43%), Gaps = 48/484 (9%)
Query: 31 KTSLLEALEELRMRREAEI--------HYEEQIGKIIVETQELKWQKETLQNQKETLAEQ 82
K +L +A+E R + +AE+ + + +++ + +LK + LQ+ KE++ Q
Sbjct: 2060 KENLAQAVEH-RKKAQAELASFKVLLDDTQSEAARVLADNLKLK---KELQSNKESVKSQ 2115
Query: 83 HKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSE 142
K+ +++L+ +EK Q + +E L+ET+ +QV+ K+V +
Sbjct: 2116 MKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175
Query: 143 MEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSAL 202
+++ + + QL+ K +++ V + +K E+ +AIQS + L
Sbjct: 2176 LQENLDSTVT-------QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
Query: 203 NKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELEL 262
+ CS+ K+ + S M E IN++ E Q + + E++L
Sbjct: 2229 KEDN----CSVLKDQLRQMS----------IHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 263 NEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQ 322
+K+ + + Q E ++++ + + L ++E+ELK LK+ Q + N L
Sbjct: 2275 QQKVCDTL---QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD--QLTDLSNSL- 2328
Query: 323 REKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKL 382
EK KE + + + E + K E+L ++ + EL+S I ++E K+
Sbjct: 2329 -EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDL-QASRELTSRLHEEINMKE--QKI 2384
Query: 383 CNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYRE 442
+ + +E+ + E+ ++ + ++ EN + Q+ + EEN + + E
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQH-DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME 2443
Query: 443 --KEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQG 500
K KKE + ++ +D S +N+ D +V + E LS L D ++I +
Sbjct: 2444 TLKTIKKE-NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKD-QLIQEA 2501
Query: 501 QTSN 504
N
Sbjct: 2502 AAEN 2505
Score = 68.6 bits (166), Expect = 3e-11
Identities = 110/510 (21%), Positives = 214/510 (41%), Gaps = 43/510 (8%)
Query: 70 ETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKAL 129
E L++Q L +A +++K L K +E QL E K K + AL
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKA---KEISNLNQLIEEFK-KNADNNSSAFTAL 742
Query: 130 QVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKY----YATITGQFGLVKENHEKL 185
+ L +V E+ +L K+ L+E E+ Y + T L+ E L
Sbjct: 743 SEERDQLLSQVKELSMVTELRAQVKQ-LEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL 801
Query: 186 EQNVR------EAIQSNKRLSALN-KKQEAEICSLKKELKKAASDLIKSKVTCQY---KM 235
+ E +Q+ L +Q I SL+ +L+ S++++ ++ K+
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 236 GEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDII-ISFQHMQQLLRQQ 294
E + L+ KE + ++ + L LE + I+E+ Q + ISF ++++ Q
Sbjct: 862 EELSQALSQKELEITKMDQLL---LEKKRDVETLQQTIEEKDQQVTEISFSMTEKMV-QL 917
Query: 295 IQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEEL 354
+ + E+K LKE L R E ++E+V+E+ E L+ +++ + EEL
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 355 NGEINKIKNELSSLKE-------THIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEM 407
E + +K E K +L + ++L + +D+ + +P E E+
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV 1037
Query: 408 STEKSENTIIQKYNTE--QEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEK 465
+K +K T QEI E ++ S+ E + +K+ +EE + + Q +
Sbjct: 1038 EEDKENKEYSEKCVTSKCQEI-EIYLKQTISEKEVELQHIRKD---LEEKLAAEEQF--Q 1091
Query: 466 SFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKD 525
+ +++ + NQ ++ L +S ++ +I + TSN + +K+ + +
Sbjct: 1092 ALVKQMNQTLQDKTNQIDL-LQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
Query: 526 -NGCTEFKSPNNHFVVLDTAIETEKIHLER 554
G +E P +L A+E EK L++
Sbjct: 1151 CTGSSEHWKPELEEKIL--ALEKEKEQLQK 1178
Score = 64.3 bits (155), Expect = 6e-10
Identities = 173/898 (19%), Positives = 346/898 (38%), Gaps = 177/898 (19%)
Query: 46 EAEIHYEEQIGKIIVETQELKWQKET-LQNQKETLAEQHKEAMAVFKK---QLQMKMCAL 101
+ + Y EQ+ +VE +++ QK+ LQ + E L E+ K A KK + K+ +L
Sbjct: 51 QERLAYAEQL---VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSL 107
Query: 102 ---------------------EEEKGKYQLATEIKEKEIEGLKETLKALQ--VSKYSLQK 138
EE+ K+ ++ +E EIE +K L+ + +S Q
Sbjct: 108 NKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL 167
Query: 139 KVSEMEQKVQLHLLAKE--DYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSN 196
++ EQ Q +E +QL E E++ +T+ Q + + +Q VRE +
Sbjct: 168 TQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQT-QAEQAAQQVVRE---KD 223
Query: 197 KRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERL 256
R + E E+ L VT E L + ++K +E +E L
Sbjct: 224 ARFETQVRLHEDELLQL---------------VTQADVETEMQQKLRVLQRKLEEHEESL 268
Query: 257 NMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLE 316
++ + + +E+T ++ Q+L QQ+Q +MEAE L+ +T
Sbjct: 269 VGRAQVVDLLQQELTAAEQR-----------NQILSQQLQ---QMEAEHNTLRNTVETER 314
Query: 317 RDNELQREK----VKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETH 372
++++ EK V E + F NLQ E L E+ ++++ S+L++ H
Sbjct: 315 EESKILLEKMELEVAERKLSFHNLQEEMHHLL----EQFEQAGQAQAELESRYSALEQKH 370
Query: 373 -IKLQEHYNKLCN-QKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREEN 430
+++E + + + QKT +E + + + ++NS++ +K+E +Q T Q++ ++
Sbjct: 371 KAEMEEKTSHILSLQKTGQELQSACDA--LKDQNSKLLQDKNEQA-VQSAQTIQQLEDQ- 426
Query: 431 MENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTL 490
+++ K+ F+ + LQ E + + V +E ++
Sbjct: 427 ----------LQQKSKEISQFLNRL---PLQQHETASQTSFPDV--YNEGTQAVTEENIA 471
Query: 491 SLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKI 550
SL K V+ +N K + I LE E K+ N T +E +
Sbjct: 472 SLQKRVVE-------LENEKGAL--LLSSIELE------ELKAENEKLSSQITLLEAQ-- 514
Query: 551 HLERTRGLDVHHTDVNLEVENNKTSFNSILN--ETAHNTYHNNNKDVS----------EN 598
RT D +++++ NK S ++ + + NT+ +K++S E
Sbjct: 515 --NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEE 572
Query: 599 EPFKQFRLLPGTREHALEKEITNSDQTK--------------------------ADLDSS 632
F + + L G R + E+ + + K + +SS
Sbjct: 573 IAFLKLQ-LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 631
Query: 633 LDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQLLTKKSECSILLSKQTSDFLQVCNDT 692
L + ++ R S + L+D ++K + KS ++ D Q D
Sbjct: 632 LPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAV------PDIGQCHQDE 685
Query: 693 LEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVK-----PNSSPGGKT 747
LE+ + + ++ ++ H + + N L K + +++ L++ +++ T
Sbjct: 686 LERLKSQI-LELELNFHKAQEIYEKN----LDEKAKEISNLNQLIEEFKKNADNNSSAFT 740
Query: 748 MCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHASQAKDVKTAVHMKTCTETEFS 807
D SQ L + + L +N + + D + ++T
Sbjct: 741 ALSEERDQLLSQVKE-LSMVTELRAQVKQLEMNLAEAERQRRLDYE--------SQTAHD 791
Query: 808 NKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNTEKTESLNDIVSGKMFSEGQLEE 865
N + + EA D+ + V NE L +E++ + + S E ++ E
Sbjct: 792 NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849
Score = 64.3 bits (155), Expect = 6e-10
Identities = 180/929 (19%), Positives = 360/929 (38%), Gaps = 140/929 (15%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQ---NQKETLAEQHKEAMAVFKKQL 94
L+ +R E ++ EEQ ++ K +TLQ NQ + L + E A+ +K +
Sbjct: 1073 LQHIRKDLEEKLAAEEQFQALV------KQMNQTLQDKTNQIDLLQAEISENQAIIQKLI 1126
Query: 95 QMKMCALEEEKGKYQLATEIKEKEIEG--------LKETLKALQVSKYSLQKKVSEM--E 144
A + + T + G L+E + AL+ K LQKK+ E
Sbjct: 1127 TSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTS 1186
Query: 145 QKVQLHLLAKEDYH--KQLSEIEKYYATITGQFGLVKENHEKLEQNVREA-IQSNKRLSA 201
+K L +++ H ++L + + Y + QF + +E + +R+ IQ + +
Sbjct: 1187 RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDG 1246
Query: 202 -LNKKQEAEICS----LKKELKKAASD-----LIKSKVTCQYKMGEENINL----TIKEQ 247
L + E CS L++ L KA +++S + + E+ + T Q
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ 1306
Query: 248 KFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQ--QIQANTEMEAEL 305
+L+E ++EL K++ + + ++ +++ FQ +Q+ +Q +I++ + E
Sbjct: 1307 IKAQLKEIEAEKVELELKVSSTTSELTKKSEEV---FQLQEQINKQGLEIESLKTVSHEA 1363
Query: 306 KVLKENNQTLERDNELQ---REKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIK 362
+V E+ Q ++LQ E ++E + K LQ K + + L+G++++ +
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQ----KLISKKEEDVSYLSGQLSEKE 1419
Query: 363 NELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNT 422
L+ ++ I+ ++ L Q + + + + ++ E EM + E I ++
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE--IGEESRA 1477
Query: 423 EQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQS 482
+Q+I+ + S KE KE ++E +L L + +
Sbjct: 1478 KQQIQRKLQAALIS-----RKEALKENKSLQE----ELSLARGTIER------------- 1515
Query: 483 EISLSKTLS-LDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVL 541
L+K+L+ ++ +V +Q + + R ++ E +DK+ E D E +S L
Sbjct: 1516 ---LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS-------L 1565
Query: 542 DTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSE---- 597
++ E+ K+ LE GL + E+E+ K+S I T H + E
Sbjct: 1566 SSSCESLKLALE---GLTEDKEKLVKEIESLKSS--KIAESTEWQEKHKELQKEYEILLQ 1620
Query: 598 ------NEPFKQFRLLPGTREHALE--KEITNSDQTKADLDSSLDIKKNPVPCQKYSLRN 649
NE + ++ R+ E ++ +++ K + + L + + K +R
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR- 1679
Query: 650 SSNVMLDDKQCKIKQIQLLTKKSECSILLSK--QTSDFLQVCNDTLEKSELTVPCDIVID 707
K K KQ ++L + E L ++ D + C +TL S ++ ++
Sbjct: 1680 --------KFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE-R 1730
Query: 708 HHVSYAAFSANSKLLLKNSD---KNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCL 764
+ Y S + L+ D + V + ++ N S D Q +
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790
Query: 765 GYLENTNVNISHLHLNNE---NSHASQAKDVKTAVHMKTCTETEFSNKKNQIDE------ 815
+ L ++ + AK AV + E +N QID+
Sbjct: 1791 QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1850
Query: 816 ------------NQVTEATKNDLFLFVSINERQHTLL-NNTEKTESLNDIVSGKMFSEGQ 862
+Q E KN L +S + + +L K LN + ++ +
Sbjct: 1851 GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910
Query: 863 LEESHSFHIEPSGDLVNRSGRSTFDLSTS 891
L+E+ E DL R +L+ S
Sbjct: 1911 LKETAE---EEKDDLEERLMNQLAELNGS 1936
Score = 59.3 bits (142), Expect = 2e-08
Identities = 105/529 (19%), Positives = 227/529 (42%), Gaps = 78/529 (14%)
Query: 25 IQLLDFKTSLLEALEELRMRREAEIH---------YEEQIGKIIVETQELKWQKETLQNQ 75
I+ L + +LL EE + + E + Y+E + +EL+ + + L+ +
Sbjct: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKE 987
Query: 76 KETLAEQHKEAMAVFKKQLQMKMCALEEE------KGKYQLA-TEIKEKEIEGLKE---- 124
E ++ +A + +K+L ++ LEEE + K ++ +E + E+E KE
Sbjct: 988 NEQ-RKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046
Query: 125 -----TLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATI-------- 171
T K ++ Y L++ +SE E ++Q H+ ++D ++L+ E++ A +
Sbjct: 1047 SEKCVTSKCQEIEIY-LKQTISEKEVELQ-HI--RKDLEEKLAAEEQFQALVKQMNQTLQ 1102
Query: 172 --TGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKV 229
T Q L++ + + +++ I SN S + + +L KE + S
Sbjct: 1103 DKTNQIDLLQAEISENQAIIQKLITSNTDAS------DGDSVALVKETVVISPPCTGSSE 1156
Query: 230 TCQYKMGEENINLTI-KEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQ 288
+ ++ E+ + L KEQ ++LQE L + +K E+ H++EE + + +Q
Sbjct: 1157 HWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ 1216
Query: 289 QLLRQQIQANTEMEAELKVLK------ENNQTLERDNELQREKVKENEEKFLNLQNEH-- 340
+ +Q + N + +L+ L+ + + D + EE +H
Sbjct: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
Query: 341 -----EKALGTWKRHAEELNG-----EINKIKNELSSLKETHIKLQEHYNKLCNQKTFEE 390
W H+E+ + + +IK +L ++ ++L+ + ++ T +
Sbjct: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
Query: 391 DKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGS 450
++ FQ ++N + E+ + K T+ + E ++ +E+ S + E +E
Sbjct: 1337 EEVFQLQEQINKQGLEIESLK---TVSHEAEVHAESLQQKLES--SQLQIAGLEHLRE-- 1389
Query: 451 FIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQ 499
+ +D+LQ S K E + +S ++ E +L+K + E+I Q
Sbjct: 1390 --LQPKLDELQKL-ISKKEEDVSYLSGQLSEKEAALTK---IQTEIIEQ 1432
Score = 51.2 bits (121), Expect = 5e-06
Identities = 73/329 (22%), Positives = 139/329 (42%), Gaps = 44/329 (13%)
Query: 19 SETLFSIQLLDFKT-SLLEAL-EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQK 76
SET FS+ + + S LE L ++L + E +H Q+ + Q +LQN++
Sbjct: 2786 SETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2845
Query: 77 ETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSL 136
+ L + ++ F+K EE K + E++ LK+ + +LQ + L
Sbjct: 2846 DHLWNELEK----FRKS--------EEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRL 2893
Query: 137 QKKVSEMEQK--------VQLHLLAKE--DYHK-----QLSEIEKYYATITGQFGLVKEN 181
K++ ++Q+ +LH L + +Y Q+ + E ++ Q L +
Sbjct: 2894 LKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR 2953
Query: 182 HEKLEQNVREAIQSNKRLSALNKKQE--AEICSLKKELKKAASDLIKSKVTCQYKMGEEN 239
EK + E + L A++ K + + + +L +EL+ ++S KV Q + E
Sbjct: 2954 MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPET 3013
Query: 240 I-------NLT-----IKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHM 287
NL ++ Q L+E EL + +++N + + EEK + I
Sbjct: 3014 SASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI-QQLNSNFSQLLEEKNTLSIQLCDT 3072
Query: 288 QQLLRQQIQANTEMEAELKVLKENNQTLE 316
Q LR+ Q ++ VL++ Q L+
Sbjct: 3073 SQSLRENQQHYGDLLNHCAVLEKQVQELQ 3101
Score = 50.1 bits (118), Expect = 1e-05
Identities = 105/506 (20%), Positives = 206/506 (40%), Gaps = 64/506 (12%)
Query: 65 LKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLA-------TEIKEK 117
LK Q L K A Q + + + QLQ K + + + L T +
Sbjct: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDV 457
Query: 118 EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATIT---GQ 174
EG T + + SLQK+V E+E + LL+ + + +E EK + IT Q
Sbjct: 458 YNEG---TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ 514
Query: 175 FGLVKENHEKLEQNVREAIQSNKRLSALNK-----------KQEAEICSLKKELKKAASD 223
+ + E E ++ + +NKR S+ + ++ E+ L E+K+A +
Sbjct: 515 NRTGEADREVSEISIVDI--ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEE 572
Query: 224 LIKSKVTCQYKMGEENINLTIKEQKFQELQER----LNMELELNE-------KINEEITH 272
+ K+ Q K EE + + +++ ++++ + M++ L + NEE +
Sbjct: 573 IAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL 632
Query: 273 IQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKEN-----------NQTLERDNEL 321
EK+ S +H Q ++I N + ELK K++ Q + + E
Sbjct: 633 PAVEKEQ--ASTEH-QSRTSEEISLN-DAGVELKSTKQDGDKSLSAVPDIGQCHQDELER 688
Query: 322 QREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK 381
+ ++ E E F Q +EK L + LN I + K + L E ++
Sbjct: 689 LKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQ 748
Query: 382 LCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENM---ENFCSDT 438
L +Q K+ V E+ + ++ +E ++ + E + +N+ +
Sbjct: 749 LLSQV-----KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 439 EYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVIS 498
E + K+ K E + + +DD+QL I ++ SQ +N+ E + + + + S
Sbjct: 804 EAKSKDVKIE---VLQNELDDVQLQFSEQSTLIRSLQSQLQNK-ESEVLEGAERVRHISS 859
Query: 499 QGQTSNVTDNRKSVTTEIKDKICLEK 524
+ + + ++K + D++ LEK
Sbjct: 860 KVEELSQALSQKELEITKMDQLLLEK 885
Score = 40.4 bits (93), Expect = 0.009
Identities = 110/569 (19%), Positives = 215/569 (37%), Gaps = 161/569 (28%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIH-----YEEQIGKIIVETQELKWQKETLQNQKETLA 80
Q++ K S + L E+++++ E+ EE++ + ++L+ LQ +K+ L+
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601
Query: 81 EQHKEAMAVFKKQLQMKMCALEEEK--GKYQLATEIKEKEIEGLKETLKALQVSKYSLQ- 137
++ E++ V QL ++ AL+EE G Y ++KE+E+ L + Q L+
Sbjct: 2602 KEI-ESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEE 2660
Query: 138 ----------KKVSEMEQKVQLHL-----------------------LAKE--DYHKQLS 162
KKV E+E K++ L LA++ + ++L
Sbjct: 2661 ELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL 2720
Query: 163 EIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEA---EICSLKKE-LK 218
+ K +T Q + L QN R+ +N+ L L +K +A E+ LK++ L
Sbjct: 2721 MVTKENKGLTAQIQSFGRSMSSL-QNSRD--HANEELDELKRKYDASLKELAQLKEQGLL 2777
Query: 219 KAASDLIKSKVTCQYKMGEENINLTIKEQKFQEL----QERLNMELELNEKINE------ 268
D + S+ EEN +L+ E+ Q+L ++ L++ +L + N+
Sbjct: 2778 NRERDALLSETAFSMNSTEEN-SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSK 2836
Query: 269 ---------------------------------------------EITHIQEEKQDIIIS 283
++ +Q ++ ++
Sbjct: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKE 2896
Query: 284 FQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNE-HEK 342
+++QQ Q Q TE+ L+E + +Q E +EN L+ Q+E H+
Sbjct: 2897 LKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQEN----LSWQHELHQL 2952
Query: 343 AL--GTWKRHAEELN--------------GEINKIKNELSSLKETHIKLQEHYNKLCNQK 386
+ +W+ H + + + EL S L+ Y + + +
Sbjct: 2953 RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012
Query: 387 TFEEDKKFQN-------------------------VPEVNNENSEMSTEKSENTI-IQKY 420
T QN + ++N+ S++ EK NT+ IQ
Sbjct: 3013 TSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEK--NTLSIQLC 3070
Query: 421 NTEQEIREE-----NMENFCSDTEYREKE 444
+T Q +RE ++ N C+ E + +E
Sbjct: 3071 DTSQSLRENQQHYGDLLNHCAVLEKQVQE 3099
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 87.4 bits (215), Expect = 6e-17
Identities = 81/382 (21%), Positives = 180/382 (47%), Gaps = 29/382 (7%)
Query: 39 EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKM 98
+E +MRR+ E+ +E++ + I E +E ++E ++ Q+E E+ K +++ + KM
Sbjct: 375 KEEKMRRQEEMMWEKE--EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 99 CALEEEKGKYQLATEIKEKEI----EGLKETLKALQVSKYSLQKKVSEMEQKVQLH---L 151
EE+ + + +EK++ E + E K + K Q+++ E+K+
Sbjct: 433 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW 492
Query: 152 LAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEIC 211
KE H+Q +I K + Q ++E EK+ + + + +++ +++ E+
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI-----REQEEMW 547
Query: 212 SLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEIT 271
++++ + + K+ + K E+ + +E+K +E +E++ + EKI E+
Sbjct: 548 REEEKMHE------QEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQ---EEKIREQ-- 596
Query: 272 HIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEE 331
+E++Q+ ++ +R+Q + E E +++ +E + E + Q EK+ E EE
Sbjct: 597 --EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 654
Query: 332 KFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ--KTFE 389
K + + ++ T R E++ + KI+ + ++E +QE K+ Q K E
Sbjct: 655 KMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 714
Query: 390 EDKKFQNVPEVNNENSEMSTEK 411
+++K Q E E E+
Sbjct: 715 QEEKMQEQEEKMRRQEEKMWEQ 736
Score = 79.7 bits (195), Expect = 1e-14
Identities = 101/518 (19%), Positives = 231/518 (44%), Gaps = 81/518 (15%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
+EEL R+A ++ + + +ELK + LQ +K L E K + + K+L+ K
Sbjct: 195 IEELTKERDA---LSLELYRNTITDEELKEKNAKLQ-EKLQLVESEKSEIQLNVKELKRK 250
Query: 98 MCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDY 157
+ E+ K L + + E + L + L+++ LQ +V E E +L+ +E
Sbjct: 251 L-----ERAKLLLPQQQLQAEADHLGKELQSVSAK---LQAQVEENELWNRLNQQQEEKM 302
Query: 158 HKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKK--QEAEICSLKK 215
+Q +I+++ I Q ++E EK+ + + + + + +K ++ E+ K+
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 362
Query: 216 ELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNE----KINEEIT 271
E + +++ K + KM + + KE+K +EL+E+++ + ++ E + EE
Sbjct: 363 EKMRRQEEMMWEK---EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 419
Query: 272 HIQEEKQDIIISFQHMQQLLRQQIQANTEMEAEL-----------KVLKENN-------- 312
QE++Q+ ++ +R+Q + E E ++ K+ +E
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 479
Query: 313 ---QTLERDNEL--QREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSS 367
+ + E+ Q+EK+ E EEK ++ + EK W++ KI+ +
Sbjct: 480 RQEEKIHEQEEIWRQKEKMHEQEEK---IRKQEEK---VWRQE--------EKIREQEEK 525
Query: 368 LKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIR 427
++E K+ +K E+++ ++ +++ + EK + + + E++IR
Sbjct: 526 IREQEEKMWRQ-----EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 428 EENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLS 487
E+ + + + + RE+EEK++ + EK +K E + + E + +
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQ------------EQEEKMWKQE--EKIREQEEKIQEQEE 626
Query: 488 KTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKD 525
K ++++ Q +T ++ E ++K+C +++
Sbjct: 627 KIREQEEKIREQ---EEMTQEQEEKMGEQEEKMCEQEE 661
Score = 77.4 bits (189), Expect = 7e-14
Identities = 99/459 (21%), Positives = 200/459 (43%), Gaps = 71/459 (15%)
Query: 39 EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKM 98
EE R+E +I E+ KI + ++++ Q+E ++ Q+E + Q + +K + +
Sbjct: 299 EEKMWRQEEKIQEWEE--KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 99 CALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYH 158
E+E+ + + EKE E ++ + + ++K+ E+E+K+ +E
Sbjct: 357 MMWEKEEKMRRQEEMMWEKE-----EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 411
Query: 159 KQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELK 218
K+ E EK ++E ++ EQ + Q K ++QE +I +K++
Sbjct: 412 KRQEE-EK-----------IREQEKRQEQEAKMWRQEEKI-----REQEEKIREQEKKMW 454
Query: 219 KAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQ 278
+ + K+ Q K+ EE +K QE +E E +++E+ EEI +E+
Sbjct: 455 RQ-----EEKIHEQEKIREE--------EKRQEQEEMWRQEEKIHEQ--EEIWRQKEKMH 499
Query: 279 DIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
+ ++ +R+Q + E +++ +E + E Q EK++E EE + +
Sbjct: 500 E-------QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 339 EHEKALGTWK------------RHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ- 385
HE+ W+ R E++ + K+ + ++E K QE K+ Q
Sbjct: 553 MHEQE-KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQE 611
Query: 386 -KTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKE 444
K E+++K Q E E E E+ E T ++E E E C E + +
Sbjct: 612 EKIREQEEKIQEQEEKIREQEEKIREQEEMT-----QEQEEKMGEQEEKMCEQEE--KMQ 664
Query: 445 EKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSE 483
E++E + +E + ++ EK + + + + Q+E E
Sbjct: 665 EQEETMWRQE---EKIREQEKKIREQEEKIREQEEMMQE 700
Score = 64.7 bits (156), Expect = 5e-10
Identities = 91/427 (21%), Positives = 176/427 (41%), Gaps = 92/427 (21%)
Query: 102 EEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQ------------------------ 137
+E+K +Q E +E+E T++ L K LQ
Sbjct: 109 DEQKASHQ-HQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 138 ----KKVSEMEQKVQLHLLAKEDYHKQLSEIEK---------YYATITGQ---------- 174
K E+EQ + K+ + + E+ K Y TIT +
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227
Query: 175 --FGLVKENHEKLEQNVREAIQSNKRLSALNKKQ--EAEICSLKKELKKAASDL---IKS 227
LV+ +++ NV+E + +R L +Q +AE L KEL+ ++ L ++
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287
Query: 228 KVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHM 287
++ + +E+K QE +E++ E EKI E+ I+E+++ + + M
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQ---EQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 288 ---QQLLRQQIQANTEMEAELK----VLKENNQTLERDNEL----------------QRE 324
++ +R+Q + E E +++ ++ E + + R E+ ++E
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 325 KVKENEEKFLNLQNEHEKALGTWKRHAEELN--GEINKIKNELSSLKETHIKLQEHYNKL 382
K++E EEK + E EK KR +E + KI+ + ++E K+ K+
Sbjct: 405 KIREQEEK----RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 460
Query: 383 CNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQK---YNTEQEIREENMENFCSDTE 439
Q+ E++K Q E+ + E + E QK + E++IR++ + + + +
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQ--EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEK 518
Query: 440 YREKEEK 446
RE+EEK
Sbjct: 519 IREQEEK 525
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 87.0 bits (214), Expect = 8e-17
Identities = 112/533 (21%), Positives = 247/533 (46%), Gaps = 66/533 (12%)
Query: 15 LQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQN 74
LQS S+ L + + LE EEL++ EE I ++ V E + + T+Q
Sbjct: 1454 LQSESDQLKE-NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 75 QKETLAEQ-HKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSK 133
Q E + ++ + +++K+ Q + + E + K + KE + L++++
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR-KAKDSALQSIESKM 1571
Query: 134 YSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAI 193
L ++ E ++++Q+ + KE E+++ + + +KEN +++ ++E+
Sbjct: 1572 LELTNRLQESQEEIQIMIKEKE-------EMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 194 QSNK---RLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQ 250
+ +++A+N+ QE ++C ++ +K + Q K+ ENI E +
Sbjct: 1625 EKEYQFLKMTAVNETQE-KMCEIEH---------LKEQFETQ-KLNLENI-----ETENI 1668
Query: 251 ELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKV--- 307
L + L+ LE + +E ++ ++ + + +++ LR+ I + E + ELK+
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 308 -LKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELS 366
LKE+ +T+++ + EK E N+Q + E + K A++L KI+ EL
Sbjct: 1729 HLKEHQETIDKLRGIVSEKTNE----ISNMQKDLEHSNDALK--AQDL-----KIQEEL- 1776
Query: 367 SLKETHIK-LQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSE--NTIIQKYNTE 423
+ H+K QE +KL + + DK ++ N N+++ + E Q +
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 424 QEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKN--EIDTVVSQDEN- 480
+++ E + S+ E +K+ K + + ++ I++L L +K +N E+ +V+ + +N
Sbjct: 1837 KDVNETQKK--VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894
Query: 481 ------------QSEISLSKTLSLDKEVISQGQTSN-VTDNRKSVTTEIKDKI 520
Q + SL +T + D E+ + +T+ ++ K ++++KI
Sbjct: 1895 RRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI 1947
Score = 82.0 bits (201), Expect = 3e-15
Identities = 180/931 (19%), Positives = 392/931 (42%), Gaps = 158/931 (16%)
Query: 27 LLDFKTSLLEALEELRMRREA-EIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKE 85
L+ K L + LE + +E + +E I I +EL+ + L+ Q+E +A++
Sbjct: 1048 LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNH 1107
Query: 86 A-------------MAVFKKQLQMKMCALEEEKGK----YQLATEIKEK--EIEGLKETL 126
A +A +++L+ K L+E++ + + +E+++K EIE LK L
Sbjct: 1108 AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNEL 1167
Query: 127 KALQVSKYSLQKKVSEMEQKV-----QLHLLAKEDYHKQLSEIEKYYATITGQFGLVKEN 181
K +++ ++ + E+ QK+ ++ + KE K L E++K + T
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKE--RKVLKELQKSFET----------E 1215
Query: 182 HEKLEQNVRE----AIQSNKRLSALN---KKQEAEICSLKKELKKAASDLIKSK-VTCQY 233
+ L +RE +Q+ + L + K+ + I L++ + + + +I ++ + +
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH 1275
Query: 234 KMGEENINLTIKEQKF-------QELQERLNMELEL-----NEKINEEITHIQEEKQDII 281
+E I + +EQ+ E QE +N ELEL K + + I+ E+ +
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKEVSETQETMN-ELELLTEQSTTKDSTTLARIEMERLRLN 1334
Query: 282 ISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHE 341
FQ Q ++I++ T+ LK +KE LE ++ +E ++E K Q++ E
Sbjct: 1335 EKFQESQ----EEIKSLTKERDNLKTIKE---ALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 342 KALGTWKRHAE--ELNGEINKIKNELSSLKETHI-------KLQEHYNKLCNQKTFEEDK 392
++L ++ E ++ E+ + K + S+L I +LQE ++++ + +E
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEM--KSVAKEKD 1445
Query: 393 KFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE-----ENMENFCSDTEYREKEEKK 447
Q + EV S+ E + + + TE+E++ + E ++ E++
Sbjct: 1446 DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKET 1505
Query: 448 EGSFIE---EIIIDDLQ-----LFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQ 499
E S I+ E I D LQ ++EK + I + E +E+ K K+ Q
Sbjct: 1506 EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 500 G-------QTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKS---PNNHFVVLDTAIETEK 549
T+ + ++++ + IK+K +++ + + N ++ E+++
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625
Query: 550 IHLERTRGLDVHHTDVNL-EVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLP 608
+ + V+ T + E+E+ K F + N + E E + ++L
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFET----------QKLNLENIETENIRLTQILH 1675
Query: 609 GTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQLL 668
E + +T ++ +L ++++ + K +LR + L +KQ ++K + +
Sbjct: 1676 ENLEEM--RSVTKERDDLRSVEETLKVERDQL---KENLRETITRDL-EKQEELKIVHMH 1729
Query: 669 TKKSECSI-----LLSKQTSDF------LQVCNDTLEKSELTVPCDIVIDHHVSYAAFSA 717
K+ + +I ++S++T++ L+ ND L+ +L + ++ I H
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH--------- 1780
Query: 718 NSKLLLKNSDKNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHL 777
+ LK + + + +V + +S+MQ LEN+N +
Sbjct: 1781 ---MHLKEQQETIDKLRGIVSEKTD--------KLSNMQKD--------LENSNAKLQE- 1820
Query: 778 HLNNENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVT--EATKNDLFLFVSINER 835
+ ++ Q +K V+ +E K QI + +T + +L L ++E
Sbjct: 1821 KIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHEN 1880
Query: 836 QHTLLNNTEKTESLNDIVSGKMFSEGQLEES 866
+ + ++ ++L + QL+ES
Sbjct: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKES 1911
Score = 81.6 bits (200), Expect = 4e-15
Identities = 181/864 (20%), Positives = 352/864 (40%), Gaps = 165/864 (19%)
Query: 61 ETQELKWQKETLQNQKETLAEQHK--EAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKE 118
E ELK +++ ++ E L + K + M + + +K E L E+ K
Sbjct: 522 EEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK- 580
Query: 119 IEGLKET---LKALQVSKYSLQKKVSEMEQKVQLHLLAKED---YHKQLSEIEKYYATIT 172
+E L+E +K LQ +Y +K+ ++ + L + ED + L + E
Sbjct: 581 VELLREKEDQIKKLQ--EYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAK 638
Query: 173 GQFGLVKENHEKLEQNVREAIQSNKRL--------SALNKKQEAEICSLKKELKKAASDL 224
+ ++ + +L++ ++E + K++ S L K++ ++ L+KEL+ A +++
Sbjct: 639 RESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQV-DLEKELQSAFNEI 697
Query: 225 IKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISF 284
K K+ ++ + E K +LQ+ LN E+E NE + EE+ + E K S
Sbjct: 698 TKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELK-----SL 752
Query: 285 QHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL 344
+ LR++IQ +E EL ++ T E+D +V E + L E +
Sbjct: 753 PSEVERLRKEIQDKSE---ELHII-----TSEKDKLF--SEVVHKESRVQGLLEE----I 798
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKLQEHY------NKLCNQKTFEEDKKFQ--- 395
G K E + K H+ ++ Y N+ NQ+ K+ Q
Sbjct: 799 GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858
Query: 396 -NVPEVNNENSEMSTEKSENT-IIQKYNTEQEIREENMENFCSDTEYREKEE----KKEG 449
++ + E S + E E T +Q+ E E +E +EN S + E+E+ +K
Sbjct: 859 SSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQ 918
Query: 450 SFIEEIII-----DDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSN 504
+EE+ DDL+ ++S + + +D+ +S+I + +++D + + +
Sbjct: 919 QTLEEVKTLTQEKDDLKQLQESLQ------IERDQLKSDIHDTVNMNIDTQEQLRNALES 972
Query: 505 VTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTD 564
+ +++++ T +K KI +E S N H + + ET+ ++ G+D
Sbjct: 973 LKQHQETINT-LKSKI--------SEEVSRNLH--MEENTGETKDEFQQKMVGIDKKQ-- 1019
Query: 565 VNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQ----FRLLPGTRE--HALEKE 618
+LE +N +T DV +NE +Q F L+ E LE
Sbjct: 1020 -DLEAKNTQTL----------------TADVKDNEIIEQQRKIFSLIQEKNELQQMLESV 1062
Query: 619 ITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQLLTKKSECSILL 678
I +Q K DL ++++ ++ N + L + K KQ +++ ++ +I
Sbjct: 1063 IAEKEQLKTDLKENIEM----------TIENQEELRLLGDELK-KQQEIVAQEKNHAI-- 1109
Query: 679 SKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVK 738
++ EL+ CD + + KL K+ +L
Sbjct: 1110 --------------KKEGELSRTCDRLAE---------VEEKLKEKSQQLQEKQQQLL-- 1144
Query: 739 PNSSPGGKTMCKNMSDMQN--SQFNNCLGYLENTNVNISHLHLN--------NENSH--A 786
+ + MS+MQ ++ N L+N + + H+ NEN
Sbjct: 1145 --------NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVK 1196
Query: 787 SQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTE-ATKNDL-FLFVSINERQHTLLNNTE 844
S K+ K ++ ETE + + I E + T TK +L + + E Q T+ E
Sbjct: 1197 SITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETI---DE 1253
Query: 845 KTESLNDIVSGKMFSEGQLEESHS 868
S+++ + ++ + LE+SH+
Sbjct: 1254 LRRSVSE-KTAQIINTQDLEKSHT 1276
Score = 72.0 bits (175), Expect = 3e-12
Identities = 134/652 (20%), Positives = 264/652 (40%), Gaps = 94/652 (14%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMA----VFKKQ 93
+E L + ++ + EE + ++ E L+ +ETL+ +++ L E +E A + ++
Sbjct: 1868 IENLNLAQKLHENLEE-MKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 94 LQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLA 153
+M + E ++ +L +I EK I+ + + K L SK LQKK+ E+++K L
Sbjct: 1927 KTARMLSKEHKETVDKLREKISEKTIQ-ISDIQKDLDKSKDELQKKIQELQKKELQLLRV 1985
Query: 154 KEDY---HKQLSEIEKYYATITGQ-----------FGLVKENHEKLEQNVREAIQSNKRL 199
KED HK+++E+E+ Q F L K+ HE LE+ R+
Sbjct: 1986 KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEI---------RI 2036
Query: 200 SALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNME 259
A K+ E+ +K+ LK M + T++E ++ Q
Sbjct: 2037 VA---KERDELRRIKESLK----------------MERDQFIATLREMIARDRQ------ 2071
Query: 260 LELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDN 319
N ++ E + + +Q + S + +++ ++ +EM+ + L + LE++
Sbjct: 2072 ---NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128
Query: 320 ELQRE---KVKENEEKFLNLQNEH-EKALGTWKRHAEELNGEINKIKNELSSLKETHIKL 375
E Q+E +VK N LQ +H EK +R + E + + K+K LS + + +
Sbjct: 2129 EFQKELSMRVKAN-LSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQ 2187
Query: 376 QEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIR-EENMENF 434
E NK E +K+ + + ++ + + E + K N ++ EE +++F
Sbjct: 2188 HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL-KLNQNMDLHIEEILKDF 2246
Query: 435 CSD------TEYRE--KEEKKEGSFIEEIIID--DLQLFEKSFKNEIDTVVSQDE----- 479
TE+++ K+ F+EE + D++ + + E D + +
Sbjct: 2247 SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNR 2306
Query: 480 -----NQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTT--EIKDKICLEKDNGCTEFK 532
N+S ++ ++ KE Q S N K +K + T
Sbjct: 2307 IIAIMNESTEFEERSATISKE-WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD 2365
Query: 533 SPNNHFVVLDTAIETEKIH-----LERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNT 587
+ N H T + TEKI L + +H ++++ N I+ +
Sbjct: 2366 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425
Query: 588 YHNNN--KDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKK 637
+ +N + E Q ++ G + + E E K DL+ + K+
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE 2477
Score = 71.6 bits (174), Expect = 4e-12
Identities = 172/849 (20%), Positives = 355/849 (41%), Gaps = 132/849 (15%)
Query: 53 EQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLAT 112
EQ K+++E E + +E + KE A++ ++ K +L K L+E+
Sbjct: 830 EQKYKMVLEENE-RMNQEIVNLSKE--AQKFDSSLGALKTELSYKTQELQEK------TR 880
Query: 113 EIKEK--EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYAT 170
E++E+ E+E LKE L+ + +++++ + + +K+Q L + ++ ++++ +
Sbjct: 881 EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES 940
Query: 171 ITGQFGLVKEN-HEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAAS-DLIKSK 228
+ + +K + H+ + N+ Q L +L + QE I +LK ++ + S +L +
Sbjct: 941 LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET-INTLKSKISEEVSRNLHMEE 999
Query: 229 VTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQ 288
T + K +E + K Q+L+ + L + K NE I E+Q I S +
Sbjct: 1000 NTGETK--DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII-----EQQRKIFSLIQEK 1052
Query: 289 QLLRQQIQANTEMEAELKV-LKEN-NQTLERDNELQR--EKVKENEEKFLNLQNEHEKAL 344
L+Q +++ + +LK LKEN T+E EL+ +++K+ +E +N K
Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNE- 403
G R + L K+K + L+E K Q+ N ++ E KK + + NE
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQE---KQQQLLN--VQEEMSEMQKKINEIENLKNEL 1167
Query: 404 -NSEMSTEKSEN---TIIQKYN----------TEQEIREENMENFCSDTEY-----REKE 444
N E++ E E + QK N E+++ +E ++F ++ ++ RE E
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227
Query: 445 ----EKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQG 500
+ KE I I + + Q + + +Q N ++ S T L +E+
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT-KLQEEIPVLH 1286
Query: 501 QTSNVTDNRKSV--TTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGL 558
+ + N K V T E +++ L + T+ + +I +ER R
Sbjct: 1287 EEQELLPNVKEVSETQETMNELELLTEQSTTK------------DSTTLARIEMERLR-- 1332
Query: 559 DVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKE 618
+N + + ++ S+ E +N K + E K +L +EH + +
Sbjct: 1333 ------LNEKFQESQEEIKSLTKE------RDNLKTIKEALEVKHDQL----KEH-IRET 1375
Query: 619 ITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQLLTKKSECSILL 678
+ ++++ + SL++K+ ++ ++ + +Q K K LL + E + L
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKD--------NETTKIVSEMEQFKPKDSALLRIEIE-MLGL 1426
Query: 679 SKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVK 738
SK+ LQ +D ++ A K L+ + + S S +K
Sbjct: 1427 SKR----LQESHDEMKS--------------------VAKEKDDLQRLQEVLQSESDQLK 1462
Query: 739 PNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHASQAKDVKTAVHM 798
N + + K++ + + +C + +N ++L+ + + S + A++
Sbjct: 1463 ENIK---EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND 1519
Query: 799 KTCTE-TEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNTEKTESLNDIVSGKM 857
K + E K+ Q + Q++E + +NE + + K +L I S +
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISEVQE-------KVNELKQFKEHRKAKDSALQSIESKML 1572
Query: 858 FSEGQLEES 866
+L+ES
Sbjct: 1573 ELTNRLQES 1581
Score = 65.9 bits (159), Expect = 2e-10
Identities = 93/502 (18%), Positives = 225/502 (44%), Gaps = 77/502 (15%)
Query: 35 LEALEELRMRREAEIHYE-EQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAV-FKK 92
LE +E +R +H E++ + E +L+ +ETL+ +++ L E +E + +K
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 93 QLQMKMCAL-----EEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKV 147
Q ++K+ + +E K + K EI +++ L+ + + K+ E +
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 148 QLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALN---K 204
+HL +++ TI G+V E +KL ++ SN +L K
Sbjct: 1780 HMHLKEQQE-------------TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK 1826
Query: 205 KQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQ--ERLNMELEL 262
E ++ +LKK++ + + + + Q K ++ +LT+ + + + L ++L+ LE
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEME---QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE 1883
Query: 263 NEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELK----VLKENNQTLERD 318
+ + +E +++ ++ + + +++ L++ + E++ ELK + KE+ +T+++
Sbjct: 1884 MKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDK- 1942
Query: 319 NELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEH 378
REK+ E + ++Q + +K+ ++ +EL + ++ + +H K+ E
Sbjct: 1943 ---LREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE- 1998
Query: 379 YNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQK--YNTEQEIREENMENFCS 436
E+ KK + +N M + + +N + K + + +EIR
Sbjct: 1999 ---------MEQLKK-----QFEAQNLSMQSVRMDNFQLTKKLHESLEEIR--------- 2035
Query: 437 DTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEV 496
+E++E + I + L++ F + ++++D ++ +K +
Sbjct: 2036 -IVAKERDELRR-------IKESLKMERDQFIATLREMIARDRQNHQV------KPEKRL 2081
Query: 497 ISQGQTSNVTDNRKSVTTEIKD 518
+S GQ ++T++ + + IK+
Sbjct: 2082 LSDGQ-QHLTESLREKCSRIKE 2102
Score = 36.6 bits (83), Expect = 0.13
Identities = 58/282 (20%), Positives = 121/282 (42%), Gaps = 33/282 (11%)
Query: 62 TQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEG 121
T++++ + +L KE+ HKE+ + ++Q ++ + K Q K +E
Sbjct: 2380 TEKIRELENSLHEAKESA--MHKESKII---KMQKELEVTNDIIAKLQAKVHESNKCLEK 2434
Query: 122 LKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLS--EIEKYYATITGQFGLVK 179
KET++ LQ K +L K + E + L K D K + E EK + K
Sbjct: 2435 TKETIQVLQ-DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQK 2493
Query: 180 ENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMG-EE 238
E L +N+R + Q+ Q+ + S + + + L TC G +
Sbjct: 2494 EVIRLLRENLRRSQQA----------QDTSVISEHTDPQPSNKPL-----TCGGGSGIVQ 2538
Query: 239 NINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQAN 298
N I + E + +E E++ K+ ++ + ++K +++ + QH+ ++ +
Sbjct: 2539 NTKALILKS------EHIRLEKEIS-KLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERT 2591
Query: 299 TEMEAELKVLKENNQTLER--DNELQREKVKENEEKFLNLQN 338
+ EA +V EN+ + +++++ ++ K NLQ+
Sbjct: 2592 LKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQD 2633
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 86.7 bits (213), Expect = 1e-16
Identities = 123/560 (21%), Positives = 252/560 (45%), Gaps = 87/560 (15%)
Query: 60 VETQELKWQKETLQN-------QKETLAEQHKEAMAVFKK--QLQMKMCALEEEKGKYQL 110
V+ E+ W T+Q Q + + E++ + K Q Q + LE EK K Q
Sbjct: 1410 VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQE 1469
Query: 111 ATE---------IKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQL 161
T +K+K++ E + L+ + LQ SEM+QKV+L E ++
Sbjct: 1470 LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQEN 1529
Query: 162 SEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAA 221
S + T+ + + L + E Q + + K++ A + + + LKK
Sbjct: 1530 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV----KQENAAVQKMVENLKKQI 1585
Query: 222 SDL-IKSKVTCQYKMGEENINLTIK----EQKFQELQERLNMELELNEKINEEITHIQEE 276
S+L IK++ ++ EN L+ K ++K QEL +RL L EK + ++E
Sbjct: 1586 SELKIKNQ-----QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEER 1639
Query: 277 KQDIIISFQHMQQLLRQQIQANT---EMEAELKVLKENNQTLERDNELQREKVK------ 327
+Q+ F ++L R ++Q++T +EAEL +K ++++N L +++++
Sbjct: 1640 EQE---KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH 1696
Query: 328 ------ENEEKFLNLQNEHEKALGTWKRHAEELNGEINK------IKNELSSLKETHIKL 375
+ ++K ++ + +EK L + +EELN ++K +++ ++++K+ K
Sbjct: 1697 RCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQ-KS 1755
Query: 376 QEHYNKLCNQKTFEEDKKFQNVPE-VNNENSEMSTEKSENTIIQKYNTEQEIREENM--- 431
EH + + +K QN+ + V N N +MS KS+ + Q+ ++ +++E M
Sbjct: 1756 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLH 1813
Query: 432 -------------ENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQD 478
E + ++++ ++ ++ ++ QL + + T+V
Sbjct: 1814 KQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE-NERLQTMVQNT 1872
Query: 479 ENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEF---KSPN 535
+ + S K L+ ++ + Q ++ + TE ++K+ L+++ C +F +SP
Sbjct: 1873 KAELTHSREKVRQLESNLLPKHQ-KHLNPSGTMNPTE-QEKLSLKRE--CDQFQKEQSPA 1928
Query: 536 NHFVVLDTAI--ETEKIHLE 553
N V ++ E E IHLE
Sbjct: 1929 NRKVSQMNSLEQELETIHLE 1948
Score = 77.0 bits (188), Expect = 9e-14
Identities = 115/547 (21%), Positives = 230/547 (42%), Gaps = 71/547 (12%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIH-YEEQIGKIIVETQELKWQKETLQNQKETLAEQHK 84
QL + S +A E ++ R E E H E+QI + E EL+ Q L+ +H+
Sbjct: 645 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 704
Query: 85 EAMAVFKKQLQMKMCALEEEKG------KYQLATEIK----------EKEIEGLKETL-- 126
E KKQLQ+K LEEEK + Q E+K E+E EGL+ +
Sbjct: 705 EE----KKQLQVK---LEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 757
Query: 127 --KALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI---------EKYYATITGQF 175
K +++ Q ++ V+ H L KE+ K+L E EK +
Sbjct: 758 EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 817
Query: 176 GLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAAS--DLIKSKVTCQY 233
++ + Q V E +S L +L + E+ L+++ ++ S + K ++T +
Sbjct: 818 SQIEAQFQSDCQKVTERCES--ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 875
Query: 234 KMGEENINLTIKEQKFQEL---QERLNMELELNEKINEEITHIQEEKQDII----ISFQH 286
+E + T+K +K L QER +E E +N + Q+ QD+ +S
Sbjct: 876 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 935
Query: 287 MQQLLRQQIQANTEMEAELKVLKE-----------NNQTLERDNELQREKVKENEEKFLN 335
L Q ++ + + EL+ +E +Q LER ++ +E K L
Sbjct: 936 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
Query: 336 LQNEHEKALGTWKRHAEELNGEINKIKNELSSLKE--THIKLQEHYNKLCNQKTFEEDKK 393
++N H+ T R E++ EI+++++++ +++ + + + + ++ ++ E D
Sbjct: 996 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1055
Query: 394 FQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIE 453
+ + E E++ + ++ ++ +EN++ + +++ +K E +
Sbjct: 1056 LSLL-----QQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVM 1110
Query: 454 EIIIDD-LQLFEKSFKNEIDTVVSQDENQSEISLSKTLSL----DKEVISQGQTSNVTDN 508
+D+ F + + + + Q+ + +++ L D EV G T +
Sbjct: 1111 SSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ 1170
Query: 509 RKSVTTE 515
R+ V E
Sbjct: 1171 RQEVKIE 1177
Score = 64.3 bits (155), Expect = 6e-10
Identities = 98/461 (21%), Positives = 197/461 (42%), Gaps = 73/461 (15%)
Query: 6 NTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQEL 65
N+ + T + +++ +++L S E ++ ++ ++ + + + EL
Sbjct: 1529 NSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISEL 1588
Query: 66 KWQKETLQNQKETLAE---QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGL 122
K + + L + L++ Q++E + ++L +C E+E G A E +E+E L
Sbjct: 1589 KIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG--NSALEEREQEKFNL 1646
Query: 123 KETLKALQVSK----YSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLV 178
KE L+ +V SL+ ++SE+ K+Q H++ +E+ H E+EK +
Sbjct: 1647 KEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQEN-HLLKDELEK-----------M 1692
Query: 179 KENH-----EKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQY 233
K+ H +Q + + N++L K++EA L +EL L KS +
Sbjct: 1693 KQLHRCPDLSDFQQKISSVLSYNEKLL---KEKEA----LSEELNSCVDKLAKSSLL--- 1742
Query: 234 KMGEENINLTIKEQKFQELQE-RLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLR 292
E I +EQK E Q L +L ++ E++ ++++ Q++ + M+ LR
Sbjct: 1743 ---EHRIATMKQEQKSWEHQSASLKSQLVASQ---EKVQNLEDTVQNVNLQMSRMKSDLR 1796
Query: 293 QQIQANTEMEAELKVLKENNQT----------LERDNELQREKVKENEEKFLNLQNEHEK 342
Q ++ E+ L + Q + L ++ + + +K +L NE ++
Sbjct: 1797 VTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ 1856
Query: 343 ALGTWKRHAEELNGEINKIKNELSSLKETHIKL--------QEHYNKLCNQKTFEEDKKF 394
L W+ + E L + K EL+ +E +L Q+H N E++K
Sbjct: 1857 LL--WQEN-ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL- 1912
Query: 395 QNVPEVNNENSEMSTEKS--ENTIIQKYNTEQEIREENMEN 433
+ E + E+S + Q + EQE+ ++EN
Sbjct: 1913 ----SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLEN 1949
Score = 60.8 bits (146), Expect = 7e-09
Identities = 179/869 (20%), Positives = 354/869 (40%), Gaps = 176/869 (20%)
Query: 56 GKIIVETQELKWQKET--------LQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK 107
G V+ QE+K ++ L+N +ET E + + + Q Q+ M + ++
Sbjct: 1165 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDR-- 1222
Query: 108 YQLATEIKEK---EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI 164
A+E K+ ++ LK+ LK L+ ++ E K +L
Sbjct: 1223 ---ASEKKQDLLFDVSVLKKKLKMLE--------RIPEASPKYKL--------------- 1256
Query: 165 EKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKK----A 220
Y ++ + ++E +E EA+++NK L+ AE+ L+ ELKK
Sbjct: 1257 --LYEDVSRENDCLQEELRMMETRYDEALENNKELT-------AEVFRLQDELKKMEEVT 1307
Query: 221 ASDLIKSKVTCQYKMGEENINLTI--KEQKFQELQERLNMELELNEKINEEITHIQEEKQ 278
+ L K + K+ E +N+ + + K ++LQE + + + +++ E
Sbjct: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCC-LWEASLENLEIEPD 1366
Query: 279 DIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
I+ + Q L + + + ++ K+ NQ LE + +L EKVK +E +L+
Sbjct: 1367 GNIL---QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL-LEKVKAHEIAWLH--- 1419
Query: 339 EHEKALGTWKRHAEELNGEINKIKNELSSL---KETHIKLQEHYNKLCNQKTFEEDKKFQ 395
GT + H E + I E ++L ++ H + Q +L +KT K Q
Sbjct: 1420 ------GTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-----KLQ 1468
Query: 396 NVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE--ENMENFCSDTEYREKEEKKEGSFIE 453
+ E + ++ + ++ E+E++ +++ CS+ + + + + E
Sbjct: 1469 ELTRKLKERVTILVKQKD--VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES---- 1522
Query: 454 EIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVT 513
+ LQ +NEI T ++++++ S + L TL+ +E + Q +T V +V
Sbjct: 1523 ----EKLQQENSILRNEI-TTLNEEDSISNLKLG-TLNGSQEEMWQ-KTETVKQENAAVQ 1575
Query: 514 TEIKDKICLEKDNGCTEFKSPNNHFVVLDTAI-ETEKIHLERTRGLDVHHTDVNLEVENN 572
+++ L+K +E K N + +T + + + E+ + L+ T++ + E
Sbjct: 1576 KMVEN---LKKQ--ISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE-- 1628
Query: 573 KTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSS 632
K NS L E E E F L++E+ + L SS
Sbjct: 1629 KEPGNSALEE-------------REQEKFN------------LKEELERCKVQSSTLVSS 1663
Query: 633 LDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQI----QLLTKKSECSILLS--------- 679
L+ + + V Q + ++ ++++ D+ + K+KQ+ L + + S +LS
Sbjct: 1664 LEAELSEVKIQTHIVQQENHLLKDELE-KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1722
Query: 680 KQTSDFLQVCNDTLEKSELTVPCDIVIDHHV--------SYAAFSANSKLLLKNSDKNVH 731
+ S+ L C D L KS L ++H + S+ SA+ K L S + V
Sbjct: 1723 EALSEELNSCVDKLAKSSL-------LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1775
Query: 732 SMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHA-SQAK 790
++ V+ + M + SD++ +Q E + LH +N+ S A
Sbjct: 1776 NLEDTVQNVN----LQMSRMKSDLRVTQQEK-----EALKQEVMSLHKQLQNAGGKSWAP 1826
Query: 791 DVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNT--EKTES 848
++ T + N++ ++ +++ + L NER T++ NT E T S
Sbjct: 1827 EIAT-------HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1879
Query: 849 LNDIVSGKMFSEGQLEESHSFHIEPSGDL 877
+ E L H H+ PSG +
Sbjct: 1880 REKVRQ----LESNLLPKHQKHLNPSGTM 1904
Score = 50.1 bits (118), Expect = 1e-05
Identities = 102/573 (17%), Positives = 216/573 (37%), Gaps = 95/573 (16%)
Query: 52 EEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLA 111
++ +G VE WQ+E ++N +E L K L + G L
Sbjct: 305 DDGMGHASVERILDTWQEEGIENSQEIL------------KALDFSL------DGNINLT 346
Query: 112 TEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATI 171
E E L Q + S + ++ + ++V + KE L + EK + +
Sbjct: 347 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 406
Query: 172 TGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTC 231
+ V ++H +E+ ++ L L+++ + I +LK EL+K +++
Sbjct: 407 ASE---VDDHHAAIER------RNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQ 457
Query: 232 QYKMGEENINLTIKEQKFQE--LQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQ 289
+ ++ +E I++ K +E +++RL + L+ N ++ E+ E+ + +
Sbjct: 458 RLELEQE-----IEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEY--------E 504
Query: 290 LLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKE--NEEKFLNLQNEHEKALGTW 347
L ++Q N E N E+ +L + EE+ ++NE+E+
Sbjct: 505 NLTNKLQRNLE-----------NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL 553
Query: 348 KRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEM 407
+ +EL E+ + + + L+ L N + E + + + SE
Sbjct: 554 QDQVDELQSELEEYRAQGRVLR----------LPLKNSPSEEVEANSGGIEPEHGLGSEE 603
Query: 408 STEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSF 467
N I+ ++++E++ + C + + D ++ +EK
Sbjct: 604 CNPL--NMSIEAELVIEQMKEQHHRDICC---------------LRLELEDKVRHYEKQL 646
Query: 468 KNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNG 527
+ + EN + ++T +L+K++ + K+ E++ + + K+
Sbjct: 647 DETVVSCKKAQENMKQRHENETHTLEKQI----------SDLKNEIAELQGQAAVLKEAH 696
Query: 528 CTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILN--ETAH 585
L +E EK HL+ L H ++ + + SF +++
Sbjct: 697 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSA 755
Query: 586 NTYHNNNKDVSENEPFKQFRLLPGTREHALEKE 618
T E E F Q +L +H LEKE
Sbjct: 756 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 788
Score = 37.0 bits (84), Expect = 0.10
Identities = 63/314 (20%), Positives = 127/314 (40%), Gaps = 38/314 (12%)
Query: 40 ELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQM--- 96
+L +E + E+ + + ++ +K Q +KE L K+ + KQLQ
Sbjct: 1766 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL----KQEVMSLHKQLQNAGG 1821
Query: 97 KMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKED 156
K A E L + K + L + Q + +++ M Q + L +
Sbjct: 1822 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1881
Query: 157 YHKQLSE--IEKYYATITGQFGLVKENHEKL------EQNVREAIQSNKRLSALNK-KQE 207
+QL + K+ + + EKL +Q +E +N+++S +N +QE
Sbjct: 1882 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1941
Query: 208 AEICSLKKE-LKKAASDLIKSKVTCQY----------------KMGEENINLTIKEQKFQ 250
E L+ E LKK L + + Q+ ++ ++ + ++F
Sbjct: 1942 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 2001
Query: 251 ELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKE 310
+LQ +L +N+ + EE+ + E + +QL+ + E+E +LK++K
Sbjct: 2002 QLQRQLLQAERINQHLQEELENRTSETN---TPQGNQEQLVTVMEERMIEVEQKLKLVKR 2058
Query: 311 NNQTLERDNELQRE 324
Q E+ N+L+ +
Sbjct: 2059 LLQ--EKVNQLKEQ 2070
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 86.7 bits (213), Expect = 1e-16
Identities = 123/560 (21%), Positives = 252/560 (45%), Gaps = 87/560 (15%)
Query: 60 VETQELKWQKETLQN-------QKETLAEQHKEAMAVFKK--QLQMKMCALEEEKGKYQL 110
V+ E+ W T+Q Q + + E++ + K Q Q + LE EK K Q
Sbjct: 1404 VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQE 1463
Query: 111 ATE---------IKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQL 161
T +K+K++ E + L+ + LQ SEM+QKV+L E ++
Sbjct: 1464 LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQEN 1523
Query: 162 SEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAA 221
S + T+ + + L + E Q + + K++ A + + + LKK
Sbjct: 1524 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV----KQENAAVQKMVENLKKQI 1579
Query: 222 SDL-IKSKVTCQYKMGEENINLTIK----EQKFQELQERLNMELELNEKINEEITHIQEE 276
S+L IK++ ++ EN L+ K ++K QEL +RL L EK + ++E
Sbjct: 1580 SELKIKNQ-----QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEER 1633
Query: 277 KQDIIISFQHMQQLLRQQIQANT---EMEAELKVLKENNQTLERDNELQREKVK------ 327
+Q+ F ++L R ++Q++T +EAEL +K ++++N L +++++
Sbjct: 1634 EQE---KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH 1690
Query: 328 ------ENEEKFLNLQNEHEKALGTWKRHAEELNGEINK------IKNELSSLKETHIKL 375
+ ++K ++ + +EK L + +EELN ++K +++ ++++K+ K
Sbjct: 1691 RCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQ-KS 1749
Query: 376 QEHYNKLCNQKTFEEDKKFQNVPE-VNNENSEMSTEKSENTIIQKYNTEQEIREENM--- 431
EH + + +K QN+ + V N N +MS KS+ + Q+ ++ +++E M
Sbjct: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLH 1807
Query: 432 -------------ENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQD 478
E + ++++ ++ ++ ++ QL + + T+V
Sbjct: 1808 KQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE-NERLQTMVQNT 1866
Query: 479 ENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEF---KSPN 535
+ + S K L+ ++ + Q ++ + TE ++K+ L+++ C +F +SP
Sbjct: 1867 KAELTHSREKVRQLESNLLPKHQ-KHLNPSGTMNPTE-QEKLSLKRE--CDQFQKEQSPA 1922
Query: 536 NHFVVLDTAI--ETEKIHLE 553
N V ++ E E IHLE
Sbjct: 1923 NRKVSQMNSLEQELETIHLE 1942
Score = 77.0 bits (188), Expect = 9e-14
Identities = 115/547 (21%), Positives = 230/547 (42%), Gaps = 71/547 (12%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIH-YEEQIGKIIVETQELKWQKETLQNQKETLAEQHK 84
QL + S +A E ++ R E E H E+QI + E EL+ Q L+ +H+
Sbjct: 639 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 698
Query: 85 EAMAVFKKQLQMKMCALEEEKG------KYQLATEIK----------EKEIEGLKETL-- 126
E KKQLQ+K LEEEK + Q E+K E+E EGL+ +
Sbjct: 699 EE----KKQLQVK---LEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 751
Query: 127 --KALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI---------EKYYATITGQF 175
K +++ Q ++ V+ H L KE+ K+L E EK +
Sbjct: 752 EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811
Query: 176 GLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAAS--DLIKSKVTCQY 233
++ + Q V E +S L +L + E+ L+++ ++ S + K ++T +
Sbjct: 812 SQIEAQFQSDCQKVTERCES--ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
Query: 234 KMGEENINLTIKEQKFQEL---QERLNMELELNEKINEEITHIQEEKQDII----ISFQH 286
+E + T+K +K L QER +E E +N + Q+ QD+ +S
Sbjct: 870 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
Query: 287 MQQLLRQQIQANTEMEAELKVLKE-----------NNQTLERDNELQREKVKENEEKFLN 335
L Q ++ + + EL+ +E +Q LER ++ +E K L
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 336 LQNEHEKALGTWKRHAEELNGEINKIKNELSSLKE--THIKLQEHYNKLCNQKTFEEDKK 393
++N H+ T R E++ EI+++++++ +++ + + + + ++ ++ E D
Sbjct: 990 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
Query: 394 FQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIE 453
+ + E E++ + ++ ++ +EN++ + +++ +K E +
Sbjct: 1050 LSLL-----QQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVM 1104
Query: 454 EIIIDD-LQLFEKSFKNEIDTVVSQDENQSEISLSKTLSL----DKEVISQGQTSNVTDN 508
+D+ F + + + + Q+ + +++ L D EV G T +
Sbjct: 1105 SSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ 1164
Query: 509 RKSVTTE 515
R+ V E
Sbjct: 1165 RQEVKIE 1171
Score = 64.3 bits (155), Expect = 6e-10
Identities = 98/461 (21%), Positives = 197/461 (42%), Gaps = 73/461 (15%)
Query: 6 NTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQEL 65
N+ + T + +++ +++L S E ++ ++ ++ + + + EL
Sbjct: 1523 NSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISEL 1582
Query: 66 KWQKETLQNQKETLAE---QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGL 122
K + + L + L++ Q++E + ++L +C E+E G A E +E+E L
Sbjct: 1583 KIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG--NSALEEREQEKFNL 1640
Query: 123 KETLKALQVSK----YSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLV 178
KE L+ +V SL+ ++SE+ K+Q H++ +E+ H E+EK +
Sbjct: 1641 KEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQEN-HLLKDELEK-----------M 1686
Query: 179 KENH-----EKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQY 233
K+ H +Q + + N++L K++EA L +EL L KS +
Sbjct: 1687 KQLHRCPDLSDFQQKISSVLSYNEKLL---KEKEA----LSEELNSCVDKLAKSSLL--- 1736
Query: 234 KMGEENINLTIKEQKFQELQE-RLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLR 292
E I +EQK E Q L +L ++ E++ ++++ Q++ + M+ LR
Sbjct: 1737 ---EHRIATMKQEQKSWEHQSASLKSQLVASQ---EKVQNLEDTVQNVNLQMSRMKSDLR 1790
Query: 293 QQIQANTEMEAELKVLKENNQT----------LERDNELQREKVKENEEKFLNLQNEHEK 342
Q ++ E+ L + Q + L ++ + + +K +L NE ++
Sbjct: 1791 VTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ 1850
Query: 343 ALGTWKRHAEELNGEINKIKNELSSLKETHIKL--------QEHYNKLCNQKTFEEDKKF 394
L W+ + E L + K EL+ +E +L Q+H N E++K
Sbjct: 1851 LL--WQEN-ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL- 1906
Query: 395 QNVPEVNNENSEMSTEKS--ENTIIQKYNTEQEIREENMEN 433
+ E + E+S + Q + EQE+ ++EN
Sbjct: 1907 ----SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLEN 1943
Score = 60.8 bits (146), Expect = 7e-09
Identities = 179/869 (20%), Positives = 354/869 (40%), Gaps = 176/869 (20%)
Query: 56 GKIIVETQELKWQKET--------LQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK 107
G V+ QE+K ++ L+N +ET E + + + Q Q+ M + ++
Sbjct: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDR-- 1216
Query: 108 YQLATEIKEK---EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI 164
A+E K+ ++ LK+ LK L+ ++ E K +L
Sbjct: 1217 ---ASEKKQDLLFDVSVLKKKLKMLE--------RIPEASPKYKL--------------- 1250
Query: 165 EKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKK----A 220
Y ++ + ++E +E EA+++NK L+ AE+ L+ ELKK
Sbjct: 1251 --LYEDVSRENDCLQEELRMMETRYDEALENNKELT-------AEVFRLQDELKKMEEVT 1301
Query: 221 ASDLIKSKVTCQYKMGEENINLTI--KEQKFQELQERLNMELELNEKINEEITHIQEEKQ 278
+ L K + K+ E +N+ + + K ++LQE + + + +++ E
Sbjct: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCC-LWEASLENLEIEPD 1360
Query: 279 DIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
I+ + Q L + + + ++ K+ NQ LE + +L EKVK +E +L+
Sbjct: 1361 GNIL---QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL-LEKVKAHEIAWLH--- 1413
Query: 339 EHEKALGTWKRHAEELNGEINKIKNELSSL---KETHIKLQEHYNKLCNQKTFEEDKKFQ 395
GT + H E + I E ++L ++ H + Q +L +KT K Q
Sbjct: 1414 ------GTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-----KLQ 1462
Query: 396 NVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE--ENMENFCSDTEYREKEEKKEGSFIE 453
+ E + ++ + ++ E+E++ +++ CS+ + + + + E
Sbjct: 1463 ELTRKLKERVTILVKQKD--VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES---- 1516
Query: 454 EIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVT 513
+ LQ +NEI T ++++++ S + L TL+ +E + Q +T V +V
Sbjct: 1517 ----EKLQQENSILRNEI-TTLNEEDSISNLKLG-TLNGSQEEMWQ-KTETVKQENAAVQ 1569
Query: 514 TEIKDKICLEKDNGCTEFKSPNNHFVVLDTAI-ETEKIHLERTRGLDVHHTDVNLEVENN 572
+++ L+K +E K N + +T + + + E+ + L+ T++ + E
Sbjct: 1570 KMVEN---LKKQ--ISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE-- 1622
Query: 573 KTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSS 632
K NS L E E E F L++E+ + L SS
Sbjct: 1623 KEPGNSALEE-------------REQEKFN------------LKEELERCKVQSSTLVSS 1657
Query: 633 LDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQI----QLLTKKSECSILLS--------- 679
L+ + + V Q + ++ ++++ D+ + K+KQ+ L + + S +LS
Sbjct: 1658 LEAELSEVKIQTHIVQQENHLLKDELE-KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1716
Query: 680 KQTSDFLQVCNDTLEKSELTVPCDIVIDHHV--------SYAAFSANSKLLLKNSDKNVH 731
+ S+ L C D L KS L ++H + S+ SA+ K L S + V
Sbjct: 1717 EALSEELNSCVDKLAKSSL-------LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
Query: 732 SMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHA-SQAK 790
++ V+ + M + SD++ +Q E + LH +N+ S A
Sbjct: 1770 NLEDTVQNVN----LQMSRMKSDLRVTQQEK-----EALKQEVMSLHKQLQNAGGKSWAP 1820
Query: 791 DVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNT--EKTES 848
++ T + N++ ++ +++ + L NER T++ NT E T S
Sbjct: 1821 EIAT-------HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1873
Query: 849 LNDIVSGKMFSEGQLEESHSFHIEPSGDL 877
+ E L H H+ PSG +
Sbjct: 1874 REKVRQ----LESNLLPKHQKHLNPSGTM 1898
Score = 50.1 bits (118), Expect = 1e-05
Identities = 102/573 (17%), Positives = 216/573 (37%), Gaps = 95/573 (16%)
Query: 52 EEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLA 111
++ +G VE WQ+E ++N +E L K L + G L
Sbjct: 299 DDGMGHASVERILDTWQEEGIENSQEIL------------KALDFSL------DGNINLT 340
Query: 112 TEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATI 171
E E L Q + S + ++ + ++V + KE L + EK + +
Sbjct: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
Query: 172 TGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTC 231
+ V ++H +E+ ++ L L+++ + I +LK EL+K +++
Sbjct: 401 ASE---VDDHHAAIER------RNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQ 451
Query: 232 QYKMGEENINLTIKEQKFQE--LQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQ 289
+ ++ +E I++ K +E +++RL + L+ N ++ E+ E+ + +
Sbjct: 452 RLELEQE-----IEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEY--------E 498
Query: 290 LLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKE--NEEKFLNLQNEHEKALGTW 347
L ++Q N E N E+ +L + EE+ ++NE+E+
Sbjct: 499 NLTNKLQRNLE-----------NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL 547
Query: 348 KRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEM 407
+ +EL E+ + + + L+ L N + E + + + SE
Sbjct: 548 QDQVDELQSELEEYRAQGRVLR----------LPLKNSPSEEVEANSGGIEPEHGLGSEE 597
Query: 408 STEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSF 467
N I+ ++++E++ + C + + D ++ +EK
Sbjct: 598 CNPL--NMSIEAELVIEQMKEQHHRDICC---------------LRLELEDKVRHYEKQL 640
Query: 468 KNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNG 527
+ + EN + ++T +L+K++ + K+ E++ + + K+
Sbjct: 641 DETVVSCKKAQENMKQRHENETHTLEKQI----------SDLKNEIAELQGQAAVLKEAH 690
Query: 528 CTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILN--ETAH 585
L +E EK HL+ L H ++ + + SF +++
Sbjct: 691 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSA 749
Query: 586 NTYHNNNKDVSENEPFKQFRLLPGTREHALEKE 618
T E E F Q +L +H LEKE
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 782
Score = 37.0 bits (84), Expect = 0.10
Identities = 63/314 (20%), Positives = 127/314 (40%), Gaps = 38/314 (12%)
Query: 40 ELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQM--- 96
+L +E + E+ + + ++ +K Q +KE L K+ + KQLQ
Sbjct: 1760 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL----KQEVMSLHKQLQNAGG 1815
Query: 97 KMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKED 156
K A E L + K + L + Q + +++ M Q + L +
Sbjct: 1816 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
Query: 157 YHKQLSE--IEKYYATITGQFGLVKENHEKL------EQNVREAIQSNKRLSALNK-KQE 207
+QL + K+ + + EKL +Q +E +N+++S +N +QE
Sbjct: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
Query: 208 AEICSLKKE-LKKAASDLIKSKVTCQY----------------KMGEENINLTIKEQKFQ 250
E L+ E LKK L + + Q+ ++ ++ + ++F
Sbjct: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
Query: 251 ELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKE 310
+LQ +L +N+ + EE+ + E + +QL+ + E+E +LK++K
Sbjct: 1996 QLQRQLLQAERINQHLQEELENRTSETN---TPQGNQEQLVTVMEERMIEVEQKLKLVKR 2052
Query: 311 NNQTLERDNELQRE 324
Q E+ N+L+ +
Sbjct: 2053 LLQ--EKVNQLKEQ 2064
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 86.7 bits (213), Expect = 1e-16
Identities = 123/560 (21%), Positives = 252/560 (45%), Gaps = 87/560 (15%)
Query: 60 VETQELKWQKETLQN-------QKETLAEQHKEAMAVFKK--QLQMKMCALEEEKGKYQL 110
V+ E+ W T+Q Q + + E++ + K Q Q + LE EK K Q
Sbjct: 1404 VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQE 1463
Query: 111 ATE---------IKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQL 161
T +K+K++ E + L+ + LQ SEM+QKV+L E ++
Sbjct: 1464 LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQEN 1523
Query: 162 SEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAA 221
S + T+ + + L + E Q + + K++ A + + + LKK
Sbjct: 1524 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV----KQENAAVQKMVENLKKQI 1579
Query: 222 SDL-IKSKVTCQYKMGEENINLTIK----EQKFQELQERLNMELELNEKINEEITHIQEE 276
S+L IK++ ++ EN L+ K ++K QEL +RL L EK + ++E
Sbjct: 1580 SELKIKNQ-----QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEER 1633
Query: 277 KQDIIISFQHMQQLLRQQIQANT---EMEAELKVLKENNQTLERDNELQREKVK------ 327
+Q+ F ++L R ++Q++T +EAEL +K ++++N L +++++
Sbjct: 1634 EQE---KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH 1690
Query: 328 ------ENEEKFLNLQNEHEKALGTWKRHAEELNGEINK------IKNELSSLKETHIKL 375
+ ++K ++ + +EK L + +EELN ++K +++ ++++K+ K
Sbjct: 1691 RCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQ-KS 1749
Query: 376 QEHYNKLCNQKTFEEDKKFQNVPE-VNNENSEMSTEKSENTIIQKYNTEQEIREENM--- 431
EH + + +K QN+ + V N N +MS KS+ + Q+ ++ +++E M
Sbjct: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLH 1807
Query: 432 -------------ENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQD 478
E + ++++ ++ ++ ++ QL + + T+V
Sbjct: 1808 KQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE-NERLQTMVQNT 1866
Query: 479 ENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEF---KSPN 535
+ + S K L+ ++ + Q ++ + TE ++K+ L+++ C +F +SP
Sbjct: 1867 KAELTHSREKVRQLESNLLPKHQ-KHLNPSGTMNPTE-QEKLSLKRE--CDQFQKEQSPA 1922
Query: 536 NHFVVLDTAI--ETEKIHLE 553
N V ++ E E IHLE
Sbjct: 1923 NRKVSQMNSLEQELETIHLE 1942
Score = 77.0 bits (188), Expect = 9e-14
Identities = 115/547 (21%), Positives = 230/547 (42%), Gaps = 71/547 (12%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIH-YEEQIGKIIVETQELKWQKETLQNQKETLAEQHK 84
QL + S +A E ++ R E E H E+QI + E EL+ Q L+ +H+
Sbjct: 639 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 698
Query: 85 EAMAVFKKQLQMKMCALEEEKG------KYQLATEIK----------EKEIEGLKETL-- 126
E KKQLQ+K LEEEK + Q E+K E+E EGL+ +
Sbjct: 699 EE----KKQLQVK---LEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 751
Query: 127 --KALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI---------EKYYATITGQF 175
K +++ Q ++ V+ H L KE+ K+L E EK +
Sbjct: 752 EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811
Query: 176 GLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAAS--DLIKSKVTCQY 233
++ + Q V E +S L +L + E+ L+++ ++ S + K ++T +
Sbjct: 812 SQIEAQFQSDCQKVTERCES--ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
Query: 234 KMGEENINLTIKEQKFQEL---QERLNMELELNEKINEEITHIQEEKQDII----ISFQH 286
+E + T+K +K L QER +E E +N + Q+ QD+ +S
Sbjct: 870 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
Query: 287 MQQLLRQQIQANTEMEAELKVLKE-----------NNQTLERDNELQREKVKENEEKFLN 335
L Q ++ + + EL+ +E +Q LER ++ +E K L
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 336 LQNEHEKALGTWKRHAEELNGEINKIKNELSSLKE--THIKLQEHYNKLCNQKTFEEDKK 393
++N H+ T R E++ EI+++++++ +++ + + + + ++ ++ E D
Sbjct: 990 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
Query: 394 FQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIE 453
+ + E E++ + ++ ++ +EN++ + +++ +K E +
Sbjct: 1050 LSLL-----QQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVM 1104
Query: 454 EIIIDD-LQLFEKSFKNEIDTVVSQDENQSEISLSKTLSL----DKEVISQGQTSNVTDN 508
+D+ F + + + + Q+ + +++ L D EV G T +
Sbjct: 1105 SSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ 1164
Query: 509 RKSVTTE 515
R+ V E
Sbjct: 1165 RQEVKIE 1171
Score = 64.3 bits (155), Expect = 6e-10
Identities = 98/461 (21%), Positives = 197/461 (42%), Gaps = 73/461 (15%)
Query: 6 NTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQEL 65
N+ + T + +++ +++L S E ++ ++ ++ + + + EL
Sbjct: 1523 NSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISEL 1582
Query: 66 KWQKETLQNQKETLAE---QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGL 122
K + + L + L++ Q++E + ++L +C E+E G A E +E+E L
Sbjct: 1583 KIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG--NSALEEREQEKFNL 1640
Query: 123 KETLKALQVSK----YSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLV 178
KE L+ +V SL+ ++SE+ K+Q H++ +E+ H E+EK +
Sbjct: 1641 KEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQEN-HLLKDELEK-----------M 1686
Query: 179 KENH-----EKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQY 233
K+ H +Q + + N++L K++EA L +EL L KS +
Sbjct: 1687 KQLHRCPDLSDFQQKISSVLSYNEKLL---KEKEA----LSEELNSCVDKLAKSSLL--- 1736
Query: 234 KMGEENINLTIKEQKFQELQE-RLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLR 292
E I +EQK E Q L +L ++ E++ ++++ Q++ + M+ LR
Sbjct: 1737 ---EHRIATMKQEQKSWEHQSASLKSQLVASQ---EKVQNLEDTVQNVNLQMSRMKSDLR 1790
Query: 293 QQIQANTEMEAELKVLKENNQT----------LERDNELQREKVKENEEKFLNLQNEHEK 342
Q ++ E+ L + Q + L ++ + + +K +L NE ++
Sbjct: 1791 VTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ 1850
Query: 343 ALGTWKRHAEELNGEINKIKNELSSLKETHIKL--------QEHYNKLCNQKTFEEDKKF 394
L W+ + E L + K EL+ +E +L Q+H N E++K
Sbjct: 1851 LL--WQEN-ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL- 1906
Query: 395 QNVPEVNNENSEMSTEKS--ENTIIQKYNTEQEIREENMEN 433
+ E + E+S + Q + EQE+ ++EN
Sbjct: 1907 ----SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLEN 1943
Score = 60.8 bits (146), Expect = 7e-09
Identities = 179/869 (20%), Positives = 354/869 (40%), Gaps = 176/869 (20%)
Query: 56 GKIIVETQELKWQKET--------LQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK 107
G V+ QE+K ++ L+N +ET E + + + Q Q+ M + ++
Sbjct: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDR-- 1216
Query: 108 YQLATEIKEK---EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI 164
A+E K+ ++ LK+ LK L+ ++ E K +L
Sbjct: 1217 ---ASEKKQDLLFDVSVLKKKLKMLE--------RIPEASPKYKL--------------- 1250
Query: 165 EKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKK----A 220
Y ++ + ++E +E EA+++NK L+ AE+ L+ ELKK
Sbjct: 1251 --LYEDVSRENDCLQEELRMMETRYDEALENNKELT-------AEVFRLQDELKKMEEVT 1301
Query: 221 ASDLIKSKVTCQYKMGEENINLTI--KEQKFQELQERLNMELELNEKINEEITHIQEEKQ 278
+ L K + K+ E +N+ + + K ++LQE + + + +++ E
Sbjct: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCC-LWEASLENLEIEPD 1360
Query: 279 DIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
I+ + Q L + + + ++ K+ NQ LE + +L EKVK +E +L+
Sbjct: 1361 GNIL---QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL-LEKVKAHEIAWLH--- 1413
Query: 339 EHEKALGTWKRHAEELNGEINKIKNELSSL---KETHIKLQEHYNKLCNQKTFEEDKKFQ 395
GT + H E + I E ++L ++ H + Q +L +KT K Q
Sbjct: 1414 ------GTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-----KLQ 1462
Query: 396 NVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE--ENMENFCSDTEYREKEEKKEGSFIE 453
+ E + ++ + ++ E+E++ +++ CS+ + + + + E
Sbjct: 1463 ELTRKLKERVTILVKQKD--VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES---- 1516
Query: 454 EIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVT 513
+ LQ +NEI T ++++++ S + L TL+ +E + Q +T V +V
Sbjct: 1517 ----EKLQQENSILRNEI-TTLNEEDSISNLKLG-TLNGSQEEMWQ-KTETVKQENAAVQ 1569
Query: 514 TEIKDKICLEKDNGCTEFKSPNNHFVVLDTAI-ETEKIHLERTRGLDVHHTDVNLEVENN 572
+++ L+K +E K N + +T + + + E+ + L+ T++ + E
Sbjct: 1570 KMVEN---LKKQ--ISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE-- 1622
Query: 573 KTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSS 632
K NS L E E E F L++E+ + L SS
Sbjct: 1623 KEPGNSALEE-------------REQEKFN------------LKEELERCKVQSSTLVSS 1657
Query: 633 LDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQI----QLLTKKSECSILLS--------- 679
L+ + + V Q + ++ ++++ D+ + K+KQ+ L + + S +LS
Sbjct: 1658 LEAELSEVKIQTHIVQQENHLLKDELE-KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1716
Query: 680 KQTSDFLQVCNDTLEKSELTVPCDIVIDHHV--------SYAAFSANSKLLLKNSDKNVH 731
+ S+ L C D L KS L ++H + S+ SA+ K L S + V
Sbjct: 1717 EALSEELNSCVDKLAKSSL-------LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
Query: 732 SMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHA-SQAK 790
++ V+ + M + SD++ +Q E + LH +N+ S A
Sbjct: 1770 NLEDTVQNVN----LQMSRMKSDLRVTQQEK-----EALKQEVMSLHKQLQNAGGKSWAP 1820
Query: 791 DVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNT--EKTES 848
++ T + N++ ++ +++ + L NER T++ NT E T S
Sbjct: 1821 EIAT-------HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1873
Query: 849 LNDIVSGKMFSEGQLEESHSFHIEPSGDL 877
+ E L H H+ PSG +
Sbjct: 1874 REKVRQ----LESNLLPKHQKHLNPSGTM 1898
Score = 50.1 bits (118), Expect = 1e-05
Identities = 102/573 (17%), Positives = 216/573 (37%), Gaps = 95/573 (16%)
Query: 52 EEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLA 111
++ +G VE WQ+E ++N +E L K L + G L
Sbjct: 299 DDGMGHASVERILDTWQEEGIENSQEIL------------KALDFSL------DGNINLT 340
Query: 112 TEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATI 171
E E L Q + S + ++ + ++V + KE L + EK + +
Sbjct: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
Query: 172 TGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTC 231
+ V ++H +E+ ++ L L+++ + I +LK EL+K +++
Sbjct: 401 ASE---VDDHHAAIER------RNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQ 451
Query: 232 QYKMGEENINLTIKEQKFQE--LQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQ 289
+ ++ +E I++ K +E +++RL + L+ N ++ E+ E+ + +
Sbjct: 452 RLELEQE-----IEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEY--------E 498
Query: 290 LLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKE--NEEKFLNLQNEHEKALGTW 347
L ++Q N E N E+ +L + EE+ ++NE+E+
Sbjct: 499 NLTNKLQRNLE-----------NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL 547
Query: 348 KRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEM 407
+ +EL E+ + + + L+ L N + E + + + SE
Sbjct: 548 QDQVDELQSELEEYRAQGRVLR----------LPLKNSPSEEVEANSGGIEPEHGLGSEE 597
Query: 408 STEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSF 467
N I+ ++++E++ + C + + D ++ +EK
Sbjct: 598 CNPL--NMSIEAELVIEQMKEQHHRDICC---------------LRLELEDKVRHYEKQL 640
Query: 468 KNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNG 527
+ + EN + ++T +L+K++ + K+ E++ + + K+
Sbjct: 641 DETVVSCKKAQENMKQRHENETHTLEKQI----------SDLKNEIAELQGQAAVLKEAH 690
Query: 528 CTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILN--ETAH 585
L +E EK HL+ L H ++ + + SF +++
Sbjct: 691 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSA 749
Query: 586 NTYHNNNKDVSENEPFKQFRLLPGTREHALEKE 618
T E E F Q +L +H LEKE
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 782
Score = 31.2 bits (69), Expect = 5.5
Identities = 52/266 (19%), Positives = 104/266 (39%), Gaps = 33/266 (12%)
Query: 40 ELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQM--- 96
+L +E + E+ + + ++ +K Q +KE L K+ + KQLQ
Sbjct: 1760 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEAL----KQEVMSLHKQLQNAGG 1815
Query: 97 KMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKED 156
K A E L + K + L + Q + +++ M Q + L +
Sbjct: 1816 KSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSRE 1875
Query: 157 YHKQLSE--IEKYYATITGQFGLVKENHEKL------EQNVREAIQSNKRLSALNK-KQE 207
+QL + K+ + + EKL +Q +E +N+++S +N +QE
Sbjct: 1876 KVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
Query: 208 AEICSLKKE-LKKAASDLIKSKVTCQY----------------KMGEENINLTIKEQKFQ 250
E L+ E LKK L + + Q+ ++ ++ + ++F
Sbjct: 1936 LETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFL 1995
Query: 251 ELQERLNMELELNEKINEEITHIQEE 276
+LQ +L +N+ + EE+ + E
Sbjct: 1996 QLQRQLLQAERINQHLQEELENRTSE 2021
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 86.7 bits (213), Expect = 1e-16
Identities = 123/560 (21%), Positives = 252/560 (45%), Gaps = 87/560 (15%)
Query: 60 VETQELKWQKETLQN-------QKETLAEQHKEAMAVFKK--QLQMKMCALEEEKGKYQL 110
V+ E+ W T+Q Q + + E++ + K Q Q + LE EK K Q
Sbjct: 1404 VKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQE 1463
Query: 111 ATE---------IKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQL 161
T +K+K++ E + L+ + LQ SEM+QKV+L E ++
Sbjct: 1464 LTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQEN 1523
Query: 162 SEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAA 221
S + T+ + + L + E Q + + K++ A + + + LKK
Sbjct: 1524 SILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETV----KQENAAVQKMVENLKKQI 1579
Query: 222 SDL-IKSKVTCQYKMGEENINLTIK----EQKFQELQERLNMELELNEKINEEITHIQEE 276
S+L IK++ ++ EN L+ K ++K QEL +RL L EK + ++E
Sbjct: 1580 SELKIKNQ-----QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEK-EPGNSALEER 1633
Query: 277 KQDIIISFQHMQQLLRQQIQANT---EMEAELKVLKENNQTLERDNELQREKVK------ 327
+Q+ F ++L R ++Q++T +EAEL +K ++++N L +++++
Sbjct: 1634 EQE---KFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLH 1690
Query: 328 ------ENEEKFLNLQNEHEKALGTWKRHAEELNGEINK------IKNELSSLKETHIKL 375
+ ++K ++ + +EK L + +EELN ++K +++ ++++K+ K
Sbjct: 1691 RCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQ-KS 1749
Query: 376 QEHYNKLCNQKTFEEDKKFQNVPE-VNNENSEMSTEKSENTIIQKYNTEQEIREENM--- 431
EH + + +K QN+ + V N N +MS KS+ + Q+ ++ +++E M
Sbjct: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLH 1807
Query: 432 -------------ENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQD 478
E + ++++ ++ ++ ++ QL + + T+V
Sbjct: 1808 KQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQE-NERLQTMVQNT 1866
Query: 479 ENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEF---KSPN 535
+ + S K L+ ++ + Q ++ + TE ++K+ L+++ C +F +SP
Sbjct: 1867 KAELTHSREKVRQLESNLLPKHQ-KHLNPSGTMNPTE-QEKLSLKRE--CDQFQKEQSPA 1922
Query: 536 NHFVVLDTAI--ETEKIHLE 553
N V ++ E E IHLE
Sbjct: 1923 NRKVSQMNSLEQELETIHLE 1942
Score = 77.0 bits (188), Expect = 9e-14
Identities = 115/547 (21%), Positives = 230/547 (42%), Gaps = 71/547 (12%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIH-YEEQIGKIIVETQELKWQKETLQNQKETLAEQHK 84
QL + S +A E ++ R E E H E+QI + E EL+ Q L+ +H+
Sbjct: 639 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 698
Query: 85 EAMAVFKKQLQMKMCALEEEKG------KYQLATEIK----------EKEIEGLKETL-- 126
E KKQLQ+K LEEEK + Q E+K E+E EGL+ +
Sbjct: 699 EE----KKQLQVK---LEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWT 751
Query: 127 --KALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI---------EKYYATITGQF 175
K +++ Q ++ V+ H L KE+ K+L E EK +
Sbjct: 752 EEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRT 811
Query: 176 GLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAAS--DLIKSKVTCQY 233
++ + Q V E +S L +L + E+ L+++ ++ S + K ++T +
Sbjct: 812 SQIEAQFQSDCQKVTERCES--ALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQEC 869
Query: 234 KMGEENINLTIKEQKFQEL---QERLNMELELNEKINEEITHIQEEKQDII----ISFQH 286
+E + T+K +K L QER +E E +N + Q+ QD+ +S
Sbjct: 870 AEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQ 929
Query: 287 MQQLLRQQIQANTEMEAELKVLKE-----------NNQTLERDNELQREKVKENEEKFLN 335
L Q ++ + + EL+ +E +Q LER ++ +E K L
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 336 LQNEHEKALGTWKRHAEELNGEINKIKNELSSLKE--THIKLQEHYNKLCNQKTFEEDKK 393
++N H+ T R E++ EI+++++++ +++ + + + + ++ ++ E D
Sbjct: 990 MENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGA 1049
Query: 394 FQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIE 453
+ + E E++ + ++ ++ +EN++ + +++ +K E +
Sbjct: 1050 LSLL-----QQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVM 1104
Query: 454 EIIIDD-LQLFEKSFKNEIDTVVSQDENQSEISLSKTLSL----DKEVISQGQTSNVTDN 508
+D+ F + + + + Q+ + +++ L D EV G T +
Sbjct: 1105 SSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ 1164
Query: 509 RKSVTTE 515
R+ V E
Sbjct: 1165 RQEVKIE 1171
Score = 64.3 bits (155), Expect = 6e-10
Identities = 98/461 (21%), Positives = 197/461 (42%), Gaps = 73/461 (15%)
Query: 6 NTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQEL 65
N+ + T + +++ +++L S E ++ ++ ++ + + + EL
Sbjct: 1523 NSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISEL 1582
Query: 66 KWQKETLQNQKETLAE---QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGL 122
K + + L + L++ Q++E + ++L +C E+E G A E +E+E L
Sbjct: 1583 KIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPG--NSALEEREQEKFNL 1640
Query: 123 KETLKALQVSK----YSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLV 178
KE L+ +V SL+ ++SE+ K+Q H++ +E+ H E+EK +
Sbjct: 1641 KEELERCKVQSSTLVSSLEAELSEV--KIQTHIVQQEN-HLLKDELEK-----------M 1686
Query: 179 KENH-----EKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQY 233
K+ H +Q + + N++L K++EA L +EL L KS +
Sbjct: 1687 KQLHRCPDLSDFQQKISSVLSYNEKLL---KEKEA----LSEELNSCVDKLAKSSLL--- 1736
Query: 234 KMGEENINLTIKEQKFQELQE-RLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLR 292
E I +EQK E Q L +L ++ E++ ++++ Q++ + M+ LR
Sbjct: 1737 ---EHRIATMKQEQKSWEHQSASLKSQLVASQ---EKVQNLEDTVQNVNLQMSRMKSDLR 1790
Query: 293 QQIQANTEMEAELKVLKENNQT----------LERDNELQREKVKENEEKFLNLQNEHEK 342
Q ++ E+ L + Q + L ++ + + +K +L NE ++
Sbjct: 1791 VTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ 1850
Query: 343 ALGTWKRHAEELNGEINKIKNELSSLKETHIKL--------QEHYNKLCNQKTFEEDKKF 394
L W+ + E L + K EL+ +E +L Q+H N E++K
Sbjct: 1851 LL--WQEN-ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKL- 1906
Query: 395 QNVPEVNNENSEMSTEKS--ENTIIQKYNTEQEIREENMEN 433
+ E + E+S + Q + EQE+ ++EN
Sbjct: 1907 ----SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLEN 1943
Score = 60.8 bits (146), Expect = 7e-09
Identities = 179/869 (20%), Positives = 354/869 (40%), Gaps = 176/869 (20%)
Query: 56 GKIIVETQELKWQKET--------LQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK 107
G V+ QE+K ++ L+N +ET E + + + Q Q+ M + ++
Sbjct: 1159 GTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDR-- 1216
Query: 108 YQLATEIKEK---EIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEI 164
A+E K+ ++ LK+ LK L+ ++ E K +L
Sbjct: 1217 ---ASEKKQDLLFDVSVLKKKLKMLE--------RIPEASPKYKL--------------- 1250
Query: 165 EKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKK----A 220
Y ++ + ++E +E EA+++NK L+ AE+ L+ ELKK
Sbjct: 1251 --LYEDVSRENDCLQEELRMMETRYDEALENNKELT-------AEVFRLQDELKKMEEVT 1301
Query: 221 ASDLIKSKVTCQYKMGEENINLTI--KEQKFQELQERLNMELELNEKINEEITHIQEEKQ 278
+ L K + K+ E +N+ + + K ++LQE + + + +++ E
Sbjct: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCC-LWEASLENLEIEPD 1360
Query: 279 DIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN 338
I+ + Q L + + + ++ K+ NQ LE + +L EKVK +E +L+
Sbjct: 1361 GNIL---QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL-LEKVKAHEIAWLH--- 1413
Query: 339 EHEKALGTWKRHAEELNGEINKIKNELSSL---KETHIKLQEHYNKLCNQKTFEEDKKFQ 395
GT + H E + I E ++L ++ H + Q +L +KT K Q
Sbjct: 1414 ------GTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT-----KLQ 1462
Query: 396 NVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE--ENMENFCSDTEYREKEEKKEGSFIE 453
+ E + ++ + ++ E+E++ +++ CS+ + + + + E
Sbjct: 1463 ELTRKLKERVTILVKQKD--VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYES---- 1516
Query: 454 EIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVT 513
+ LQ +NEI T ++++++ S + L TL+ +E + Q +T V +V
Sbjct: 1517 ----EKLQQENSILRNEI-TTLNEEDSISNLKLG-TLNGSQEEMWQ-KTETVKQENAAVQ 1569
Query: 514 TEIKDKICLEKDNGCTEFKSPNNHFVVLDTAI-ETEKIHLERTRGLDVHHTDVNLEVENN 572
+++ L+K +E K N + +T + + + E+ + L+ T++ + E
Sbjct: 1570 KMVEN---LKKQ--ISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE-- 1622
Query: 573 KTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSS 632
K NS L E E E F L++E+ + L SS
Sbjct: 1623 KEPGNSALEE-------------REQEKFN------------LKEELERCKVQSSTLVSS 1657
Query: 633 LDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQI----QLLTKKSECSILLS--------- 679
L+ + + V Q + ++ ++++ D+ + K+KQ+ L + + S +LS
Sbjct: 1658 LEAELSEVKIQTHIVQQENHLLKDELE-KMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1716
Query: 680 KQTSDFLQVCNDTLEKSELTVPCDIVIDHHV--------SYAAFSANSKLLLKNSDKNVH 731
+ S+ L C D L KS L ++H + S+ SA+ K L S + V
Sbjct: 1717 EALSEELNSCVDKLAKSSL-------LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQ 1769
Query: 732 SMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHA-SQAK 790
++ V+ + M + SD++ +Q E + LH +N+ S A
Sbjct: 1770 NLEDTVQNVN----LQMSRMKSDLRVTQQEK-----EALKQEVMSLHKQLQNAGGKSWAP 1820
Query: 791 DVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNT--EKTES 848
++ T + N++ ++ +++ + L NER T++ NT E T S
Sbjct: 1821 EIAT-------HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHS 1873
Query: 849 LNDIVSGKMFSEGQLEESHSFHIEPSGDL 877
+ E L H H+ PSG +
Sbjct: 1874 REKVRQ----LESNLLPKHQKHLNPSGTM 1898
Score = 50.1 bits (118), Expect = 1e-05
Identities = 102/573 (17%), Positives = 216/573 (37%), Gaps = 95/573 (16%)
Query: 52 EEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLA 111
++ +G VE WQ+E ++N +E L K L + G L
Sbjct: 299 DDGMGHASVERILDTWQEEGIENSQEIL------------KALDFSL------DGNINLT 340
Query: 112 TEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATI 171
E E L Q + S + ++ + ++V + KE L + EK + +
Sbjct: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
Query: 172 TGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTC 231
+ V ++H +E+ ++ L L+++ + I +LK EL+K +++
Sbjct: 401 ASE---VDDHHAAIER------RNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQ 451
Query: 232 QYKMGEENINLTIKEQKFQE--LQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQ 289
+ ++ +E I++ K +E +++RL + L+ N ++ E+ E+ + +
Sbjct: 452 RLELEQE-----IEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEY--------E 498
Query: 290 LLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKE--NEEKFLNLQNEHEKALGTW 347
L ++Q N E N E+ +L + EE+ ++NE+E+
Sbjct: 499 NLTNKLQRNLE-----------NVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVL 547
Query: 348 KRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEM 407
+ +EL E+ + + + L+ L N + E + + + SE
Sbjct: 548 QDQVDELQSELEEYRAQGRVLR----------LPLKNSPSEEVEANSGGIEPEHGLGSEE 597
Query: 408 STEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSF 467
N I+ ++++E++ + C + + D ++ +EK
Sbjct: 598 CNPL--NMSIEAELVIEQMKEQHHRDICC---------------LRLELEDKVRHYEKQL 640
Query: 468 KNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNG 527
+ + EN + ++T +L+K++ + K+ E++ + + K+
Sbjct: 641 DETVVSCKKAQENMKQRHENETHTLEKQI----------SDLKNEIAELQGQAAVLKEAH 690
Query: 528 CTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILN--ETAH 585
L +E EK HL+ L H ++ + + SF +++
Sbjct: 691 HEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQ-HEMELKARLTQAQASFEREREGLQSSA 749
Query: 586 NTYHNNNKDVSENEPFKQFRLLPGTREHALEKE 618
T E E F Q +L +H LEKE
Sbjct: 750 WTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE 782
Score = 42.4 bits (98), Expect = 0.002
Identities = 67/311 (21%), Positives = 126/311 (40%), Gaps = 59/311 (18%)
Query: 53 EQIGKIIVETQELKWQKET-----LQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK 107
+++ ++ E Q+L WQ+ +QN K L ++ +QL+ + ++
Sbjct: 1839 DKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKV-----RQLESNLLPKHQKHLN 1893
Query: 108 YQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEM---EQKVQLHLLAKEDYHK----- 159
E+E LK Q + +KVS+M EQ+++ L E K
Sbjct: 1894 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1953
Query: 160 --QLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICS--LKK 215
QL E++ +T T + + L+Q + + L + +AE + L++
Sbjct: 1954 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2013
Query: 216 ELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELEL-NEKINEEITHIQ 274
EL+ S+ G + +T+ E++ E++++L + L EK+N+
Sbjct: 2014 ELENRTSET-------NTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQ------ 2060
Query: 275 EEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNEL--QREKVKEN--- 329
L++Q+ NT+ +A +K L N L + E+ QR+K E
Sbjct: 2061 ----------------LKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNY 2104
Query: 330 --EEKFLNLQN 338
EEK +L N
Sbjct: 2105 LLEEKIASLSN 2115
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 86.7 bits (213), Expect = 1e-16
Identities = 148/682 (21%), Positives = 278/682 (40%), Gaps = 90/682 (13%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKE 85
++ + + + E EE+ R + E+Q + E +E+ + E E +K+
Sbjct: 1111 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1170
Query: 86 AMAVFKKQLQMKMCALEEEKGKYQL-ATEIKEKEIEG---LKETLKALQVSKYSLQKKVS 141
A F+K + LEE +++ A +++K + L E + +LQ K L+K+ S
Sbjct: 1171 REAEFQKMRR----DLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKS 1226
Query: 142 EMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSA 201
E++ ++ E K + EK T+ Q +K E+ ++ + E LSA
Sbjct: 1227 ELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE-------LSA 1279
Query: 202 LNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELE 261
+ E ++L + K + Q G+ Q F + E L +LE
Sbjct: 1280 QKARLHTESGEFSRQLDE------KDAMVSQLSRGK---------QAFTQQIEELKRQLE 1324
Query: 262 LNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELK--VLKENNQTLERDN 319
K + H + S +H LLR+Q + E +AEL+ + K N++ +
Sbjct: 1325 EETKAKSTLAHALQ-------SARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT 1377
Query: 320 ELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHY 379
+ + + ++ EE E +K L + AEE + + ++ +SL++T +LQ
Sbjct: 1378 KYETDAIQRTEE-----LEEAKKKLAQRLQDAEE---HVEAVNSKCASLEKTKQRLQNEV 1429
Query: 380 NKL------CNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMEN 433
L N DKK +N +V E +K E T + +++E R + E
Sbjct: 1430 EDLMIDVERSNAACIALDKKQRNFDKVLAE----WKQKYEETQAELEASQKESRSLSTEL 1485
Query: 434 FCSDTEYREKEE-----KKEGSFIEEIIIDDLQLFEKSFK--NEIDTVVSQ-DENQSEIS 485
F Y E + K+E +++ I D + + K +E++ V Q D +SE+
Sbjct: 1486 FKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQ 1545
Query: 486 LS---KTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLD 542
S SL+ E +G+ + V +EI KI EKD + K NH V++
Sbjct: 1546 TSLEEAEASLEHE---EGKILRIQLELNQVKSEIDRKIA-EKDEELDQLK--RNHLRVVE 1599
Query: 543 TAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFK 602
+ ++ T ++ + L + K LNE H N + +
Sbjct: 1600 S--------MQSTLDAEIRSRNDALRI---KKKMEGDLNEMEIQLNHANRQAAEALRNLR 1648
Query: 603 QFR-LLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCK 661
+ +L T+ H L+ I D K L + ++ + N + + LR +++ ++ K
Sbjct: 1649 NTQGILKDTQLH-LDDAIRGQDDLKEQL-AMVERRANLMQAEVEELR--ASLERTERGRK 1704
Query: 662 IKQIQLLTKKSECSILLSKQTS 683
+ + +LL +L ++ TS
Sbjct: 1705 MAEQELLDASERVQLLHTQNTS 1726
Score = 85.5 bits (210), Expect = 2e-16
Identities = 121/587 (20%), Positives = 256/587 (43%), Gaps = 71/587 (12%)
Query: 30 FKTSLLEALEELRMRREAEIHYEEQI---GKII-VETQELKWQKETL----QNQKETLAE 81
FK LL LEE+R + A++ Q G ++ VE +++ ++E++ N + +
Sbjct: 769 FKAGLLGTLEEMRDEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNV 828
Query: 82 QHKEAMAV-FKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKV 140
+H M + FK + +K E+E + E ++E+ + K L+ +L ++
Sbjct: 829 KHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEK 888
Query: 141 SEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLS 200
++++ +VQ A D ++ ++ K + + V E E E+ N L+
Sbjct: 889 NDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELT 941
Query: 201 ALNKKQEAEICSLKKEL-------------KKAASDLIKSKVTCQYKMGEENINLTIKEQ 247
A +K E E LKK++ K A + +K+ + E LT +++
Sbjct: 942 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001
Query: 248 KFQELQERLNMELELNE-KIN---EEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEA 303
QE ++ +L++ E K+N + T ++++ D+ S + ++L +A ++E
Sbjct: 1002 ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG 1061
Query: 304 ELKVLKENNQTLERDNELQREKVKENEEKFLNLQN--EHEKALG-TWKRHAEELNGEINK 360
+LK+ +E+ E D + EK+K+ E + NLQ E E+AL ++ +EL I +
Sbjct: 1062 DLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEE 1121
Query: 361 IKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKY 420
++ E+ + + + K ++ + L +++ E ++ + + EM+ K QK
Sbjct: 1122 LEEEIEAERASRAKAEKQRSDL-SRELEEISERLEEAGGATSAQIEMN--KKREAEFQK- 1177
Query: 421 NTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDEN 480
+++ E +++ + R+K E+ ID LQ ++ + E + E
Sbjct: 1178 -MRRDLEESTLQHEATAAALRKKHADSVAELGEQ--IDSLQRVKQKLEKE------KSEL 1228
Query: 481 QSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVV 540
+ EI+ L+ + E +S+ + + +K+C ++ +E K+
Sbjct: 1229 KMEIN---DLASNMETVSKAKAN-------------FEKMCRTLEDQLSEIKTKEEEQQR 1272
Query: 541 LDTAIETEKIHL-----ERTRGLDVHHTDVNLEVENNKTSFNSILNE 582
L + +K L E +R LD V+ ++ K +F + E
Sbjct: 1273 LINELSAQKARLHTESGEFSRQLDEKDAMVS-QLSRGKQAFTQQIEE 1318
Score = 72.0 bits (175), Expect = 3e-12
Identities = 91/491 (18%), Positives = 225/491 (45%), Gaps = 53/491 (10%)
Query: 16 QSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQI----------GKIIVETQEL 65
Q S +L S +L K + E+L+ L + + +++I GK I E +++
Sbjct: 1475 QKESRSL-STELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKV 1533
Query: 66 KWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKET 125
K Q + +++ +T E+ + ++ + ++ L + K + K++E++ LK
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRN 1593
Query: 126 -LKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHK---QLSEIEKYYA----TITGQFGL 177
L+ ++ + +L ++ +++ + D ++ QL+ + A + G+
Sbjct: 1594 HLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI 1653
Query: 178 VKENHEKLEQNVREAIQSNKRLSALNKK---QEAEICSLKKELKKAASDLIKSKVTCQYK 234
+K+ L+ +R ++L+ + ++ +AE+ L+ L++ K
Sbjct: 1654 LKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGR---------K 1704
Query: 235 MGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQ 294
M E+ L ++ Q L + + +K+ +I+ IQ E +DI+ ++ ++ ++
Sbjct: 1705 MAEQE--LLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA 1762
Query: 295 IQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEEL 354
I M ELK ++ + LER + + VK+ + L L + AL K+ ++L
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ---LRLDEAEQLALKGGKKQIQKL 1819
Query: 355 NGEINKIKNELSSLKETHIK----LQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTE 410
+ ++++E+ S ++ +++ L++H ++ + T++ ++ +N+ + + ++ T+
Sbjct: 1820 EARVRELESEVESEQKHNVEAVKGLRKHERRV-KELTYQTEEDRKNILRLQDLVDKLQTK 1878
Query: 411 KSENTIIQKYNTE-QEIREENMENFCSDTEYR-EKEEKKEGSFIEEIIIDDLQLFEKSFK 468
++ Y + +E E++ N + + E EE KE + I E ++ L++ +
Sbjct: 1879 ------VKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSR--- 1929
Query: 469 NEIDTVVSQDE 479
E+ T V +E
Sbjct: 1930 -EVHTKVISEE 1939
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 85.9 bits (211), Expect = 2e-16
Identities = 115/541 (21%), Positives = 234/541 (43%), Gaps = 63/541 (11%)
Query: 30 FKTSLLEALEELRMRREAEIHYEEQIGKIIVETQ--------ELKWQKETLQNQKETLAE 81
FK LL LEE+R +E++ +II Q ++++K + + +
Sbjct: 765 FKAGLLGLLEEMR---------DERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQ 815
Query: 82 QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVS 141
+ A K MK+ K K L + +EKE+ +KE L+ + + +
Sbjct: 816 WNIRAFMGVKNWPWMKLYF----KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRK 871
Query: 142 EMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVRE-------AIQ 194
E+E+K+ L K D Q+ + A + + +N +LE V+E +
Sbjct: 872 ELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEE 931
Query: 195 SNKRLSALNKKQEAEICSLKKEL-------------KKAASDLIKSKVTCQYKMGEENIN 241
N L+A +K E E LK+++ K A + +K+ + E
Sbjct: 932 MNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK 991
Query: 242 LTIKEQKFQELQERLNMELELNE-KIN---EEITHIQEEKQDIIISFQHMQQLLRQQIQA 297
LT +++ QE ++ +L+ E K+N + ++++ D+ S + +++ +A
Sbjct: 992 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERA 1051
Query: 298 NTEMEAELKVLKENNQTLERDNEL--QREKVKENEEKFLNLQNEHEKALGT-WKRHAEEL 354
++E +LK+ +E+ LE D + +R K K+ E LN + E E+ALG+ ++ +EL
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111
Query: 355 NGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENS-EMSTEKSE 413
I +++ EL + + K++ KL + + E ++ + + E S ++ K
Sbjct: 1112 QARIEELEEELEAERTARAKVE----KLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1167
Query: 414 NTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEI-----IIDDLQLFEKSFK 468
QK +++ E +++ + R+K E+I + L+ + FK
Sbjct: 1168 EAEFQK--MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
Query: 469 NEIDTVVSQDEN--QSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDN 526
E+D V S E +++ +L K ++ +++ S + ++SV + L+ +N
Sbjct: 1226 LELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE-HRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 527 G 527
G
Sbjct: 1285 G 1285
Score = 70.9 bits (172), Expect = 6e-12
Identities = 115/536 (21%), Positives = 201/536 (37%), Gaps = 60/536 (11%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKE 85
+L + + + E EEL R A E+ + E +E+ + E E +K+
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK 1166
Query: 86 AMAVFKKQLQ-MKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEME 144
A F+K + ++ L+ E L + + E L E + LQ K L+K+ SE +
Sbjct: 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE-LGEQIDNLQRVKQKLEKEKSEFK 1225
Query: 145 QKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNK 204
++ E K + +EK T+ Q + E+ +++V + +L N
Sbjct: 1226 LELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN- 1284
Query: 205 KQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQ-----KFQELQERLNME 259
E+ E + S L + K+T Y E++ ++E+ + +
Sbjct: 1285 ---GELSRQLDEKEALISQLTRGKLT--YTQQLEDLKRQLEEEVKAKNALAHALQSARHD 1339
Query: 260 LELNEKINEEITHIQEEKQDIIISF-----QHMQQLLRQQIQANTEMEAELKVLKENNQT 314
+L + EE T + E Q ++ Q + IQ E+E K L + Q
Sbjct: 1340 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Query: 315 LERDNELQREKVKENEEKFLNLQNEHE------------------------KALGTWKRH 350
E E K E+ LQNE E K L WK+
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459
Query: 351 AEELNGEINKIKNELSSLKETHIKLQEHYNK-LCNQKTFEEDKKFQNVPEVNNENSEMST 409
EE E+ + E SL KL+ Y + L + +TF+ + K N+ E ++ +E
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK--NLQEEISDLTE-QL 1516
Query: 410 EKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKN 469
S TI + +++ E ME + E E +EG + QL K
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR------AQLEFNQIKA 1570
Query: 470 EIDTVVSQDENQSE--------ISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIK 517
EI+ +++ + + E + S SLD E S+ + V + E++
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Score = 69.3 bits (168), Expect = 2e-11
Identities = 106/521 (20%), Positives = 216/521 (41%), Gaps = 60/521 (11%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQ----KETLQNQKETLAE 81
QL+ K L ++E+ R E E EE ++ + ++L+ + K + + + TLA+
Sbjct: 907 QLIKNKIQLEAKVKEMNERLEDE---EEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 82 QHKEAMAVFKK--QLQMKMCALEE-------EKGKYQLATEIKEKEIEGLKETLKALQVS 132
KE A K L +M L+E EK Q A + +++ ++ + L +
Sbjct: 964 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023
Query: 133 KYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREA 192
K L+++V ++E + E K ++E+ + G L +E+ LE + ++
Sbjct: 1024 KVKLEQQVDDLEGSL-------EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Query: 193 IQSNKR----LSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQK 248
+ K+ L+ALN + E E +L +L+K +L + +
Sbjct: 1077 DERLKKKDFELNALNARIEDEQ-ALGSQLQKKLKEL---------------------QAR 1114
Query: 249 FQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVL 308
+EL+E L E K+ + + + E ++I + QI+ N + EAE + +
Sbjct: 1115 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1174
Query: 309 KENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSL 368
+ + + +E +++ + E L K+ E+ E ++++S
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1234
Query: 369 KETHIKLQEHYNKLC----NQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQ 424
E IK + + K+C +Q K + VN+ S+ + ++EN + + E+
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK 1294
Query: 425 EIREENMENFCSDTEYREKEEKKEGSFIEEIIIDD-LQLFEKSFKNEIDTVVSQ--DENQ 481
E + Y ++ E + EE+ + L +S +++ D + Q +E +
Sbjct: 1295 EALISQLTR--GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352
Query: 482 SEISLSKTLSLDKEVISQGQTSNVTD--NRKSVTTEIKDKI 520
++ L + LS ++Q +T TD R E K K+
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1393
Score = 62.8 bits (151), Expect = 2e-09
Identities = 96/524 (18%), Positives = 214/524 (40%), Gaps = 91/524 (17%)
Query: 8 ESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKW 67
ES S S +L K + E+LE L + + +E+I + T++L
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL---TEQLGS 1518
Query: 68 QKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKY--------QLATEI----- 114
+T+ ++ + E M + + L+ +LE E+GK Q+ EI
Sbjct: 1519 SGKTIHELEKVRKQLEAEKMEL-QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577
Query: 115 -KEKEIEGLKET-LKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHK---QLSEIEKYYA 169
K++E+E K L+ + + SL + + +++ + D ++ QLS + A
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637
Query: 170 TITGQF----GLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLI 225
Q L+K+ +L+ VR + ++ + ++ L+ EL+
Sbjct: 1638 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE-ELRAVVEQTE 1696
Query: 226 KSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQ 285
+S+ K+ E+ + T ++ Q L + + +K++ +++ +Q E ++ + +
Sbjct: 1697 RSR-----KLAEQELIET--SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR 1749
Query: 286 HMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALG 345
+ ++ ++ I M ELK ++ + LER + + +K+ + + L + AL
Sbjct: 1750 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR---LDEAEQIALK 1806
Query: 346 TWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENS 405
K+ ++L + +++NEL + E K+ N S
Sbjct: 1807 GGKKQLQKLEARVRELENELEA----------------------EQKR--------NAES 1836
Query: 406 EMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEK 465
KSE I + Y+ +E++K +++ ++D LQL K
Sbjct: 1837 VKGMRKSERRI-------------------KELTYQTEEDRKNLLRLQD-LVDKLQLKVK 1876
Query: 466 SFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNR 509
++K + + + E Q+ +LSK + E+ + +++ +++
Sbjct: 1877 AYKRQAE----EAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1916
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 85.9 bits (211), Expect = 2e-16
Identities = 126/700 (18%), Positives = 282/700 (40%), Gaps = 84/700 (12%)
Query: 25 IQLLDFKTSLLEALEELRMRREAE--IHYEEQIGKII---VETQELKWQKETLQNQKETL 79
++++ K + LEA+ + E + + E+ + K+ ++ +EL+ + Q + +
Sbjct: 654 MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI 713
Query: 80 AEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKK 139
+ A +K L + +GK ++ +++E ++ +K L++ K + K
Sbjct: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKK--LRQQLEAAEKQIKHLEIEKNAESSK 771
Query: 140 VSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRL 199
S + +++Q L + + LSE+ + T+ + ++K EK + EA+ + +
Sbjct: 772 ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILK---EKFAEASEEAVSVQRSM 828
Query: 200 -SALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNM 258
+NK + E ++ +SDL K + NL E KF+E ER
Sbjct: 829 QETVNKLHQKE-----EQFNMLSSDLEKLRE-----------NLADMEAKFREKDEREEQ 872
Query: 259 ELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERD 318
++ EK+ +I I + D M LR + + E++ +L EN L++
Sbjct: 873 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKS 932
Query: 319 NELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEH 378
E K ++++++ E +K L +R +L ++ N+ LK
Sbjct: 933 IEDMTVKAEQSQQEAAKKHEEEKKEL---ERKLSDLEKKMETSHNQCQELK-------AR 982
Query: 379 YNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDT 438
Y + ++ + ++ QN+ + T++ + + REEN
Sbjct: 983 YERATSETKTKHEEILQNL---------------QKTLLDTEDKLKGAREENSGLLQELE 1027
Query: 439 EYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVS-QDENQSEISLSKTLSLDKEVI 497
E R++ +K + + E D +Q+ E+ K + +T+ S +D Q+ L L + +
Sbjct: 1028 ELRKQADKAKAAQTAE---DAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL----DTL 1080
Query: 498 SQGQTSNVTD-NRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTR 556
+ NV + N+ ++++ E K +A++ E + L
Sbjct: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
Query: 557 GLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALE 616
G + ++E + S+LN +K + + + K +L+
Sbjct: 1141 GRSRDEVTSHQKLEEER----SVLNNQLLEMKKRESKFIKDADEEKA----------SLQ 1186
Query: 617 KEITNSDQTKADLDSSLDIKKNPVP------CQKYSLRNSSNVMLDDK---QCKIKQIQL 667
K I+ + + D+ L+ +N V SL + + DK + K+K ++L
Sbjct: 1187 KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
Query: 668 LTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVID 707
K+++ + S +D ++ ++S++ +++D
Sbjct: 1247 QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVD 1286
Score = 58.2 bits (139), Expect = 4e-08
Identities = 160/851 (18%), Positives = 327/851 (38%), Gaps = 122/851 (14%)
Query: 135 SLQKKVSEMEQKVQLHLLAKEDYHK-QLSEIEKYYATITGQFGLVKENHEKLEQNVREAI 193
+LQ+ + E +Q ++ LLA+ D + ++++ + I + L ++ H++ + +
Sbjct: 352 ALQEALKEKQQHIE-QLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 194 QSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENI------------- 240
+ + +++ E+ + +E K+ DL Q+++ EE+I
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDL-------QFRVEEESITKGDLEVATVSEK 463
Query: 241 --------NLTIKEQKFQELQERLNM-----ELELNEKINEEITHIQEEKQDIIISFQHM 287
+L ++ Q+ EL+ RL +++++ + +EI+ +QE+ + Q
Sbjct: 464 SRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE 523
Query: 288 QQLLRQQIQANTEM-EAELKVLKENNQTLERDNELQREKV----KEN------------- 329
L++ A E + E+K L + L ++NE + K+ KEN
Sbjct: 524 ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 583
Query: 330 -----EEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCN 384
++ L+ K LGT EL +I K++ + Q L N
Sbjct: 584 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR----------LDYQHEIENLQN 633
Query: 385 QKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKE 444
Q+ E + + E K I +K N+ + IR + + D E E
Sbjct: 634 QQDSER--------AAHAKEMEALRAKLMKVIKEKENSLEAIRSK--LDKAEDQHLVEME 683
Query: 445 EKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLD--KEVISQGQT 502
+ EI + +L++ + NE V+ +Q + + K L LD ++ S+G+
Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKC-NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK- 741
Query: 503 SNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHH 562
S + R+ + K LE + K+ + + ++ + + V
Sbjct: 742 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801
Query: 563 TDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSE-NEPFKQFRLLPGTREHA------L 615
T + E++ K F + +E A + + + V++ ++ +QF +L E +
Sbjct: 802 T-LEKELQILKEKF-AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 859
Query: 616 EKEITNSDQTKADLDSSLDIKKNPV-PCQKYSLRNSSNV--MLDD---KQCKIKQIQL-L 668
E + D+ + L + + +N + K S NSS + M D+ K+ ++++QL L
Sbjct: 860 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919
Query: 669 TKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDK 728
TK +E + L K D + +++ H L K +
Sbjct: 920 TKANENASFLQKSIEDMTVKAEQSQQEA--------AKKHEEEKKELERKLSDLEKKMET 971
Query: 729 NVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQ------FNNCLGYLENTNVNISHL-HLNN 781
+ + L +T K+ +QN Q + G E + + L L
Sbjct: 972 SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031
Query: 782 ENSHASQAKDVKTAVHM-----KTCTET----EFSNKKNQIDENQVTEATKNDLFLFVSI 832
+ A A+ + A+ + K TET E + + N +N++ +N+L +
Sbjct: 1032 QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEEL 1091
Query: 833 NERQHTLLNNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSD 892
N+ + L +K E + + Q + S E + L GRS ++++
Sbjct: 1092 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1151
Query: 893 KKTEKTPVYMN 903
K E+ V N
Sbjct: 1152 KLEEERSVLNN 1162
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 85.9 bits (211), Expect = 2e-16
Identities = 126/700 (18%), Positives = 282/700 (40%), Gaps = 84/700 (12%)
Query: 25 IQLLDFKTSLLEALEELRMRREAE--IHYEEQIGKII---VETQELKWQKETLQNQKETL 79
++++ K + LEA+ + E + + E+ + K+ ++ +EL+ + Q + +
Sbjct: 689 MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI 748
Query: 80 AEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKK 139
+ A +K L + +GK ++ +++E ++ +K L++ K + K
Sbjct: 749 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKK--LRQQLEAAEKQIKHLEIEKNAESSK 806
Query: 140 VSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRL 199
S + +++Q L + + LSE+ + T+ + ++K EK + EA+ + +
Sbjct: 807 ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILK---EKFAEASEEAVSVQRSM 863
Query: 200 -SALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNM 258
+NK + E ++ +SDL K + NL E KF+E ER
Sbjct: 864 QETVNKLHQKE-----EQFNMLSSDLEKLRE-----------NLADMEAKFREKDEREEQ 907
Query: 259 ELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERD 318
++ EK+ +I I + D M LR + + E++ +L EN L++
Sbjct: 908 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKS 967
Query: 319 NELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEH 378
E K ++++++ E +K L +R +L ++ N+ LK
Sbjct: 968 IEDMTVKAEQSQQEAAKKHEEEKKEL---ERKLSDLEKKMETSHNQCQELK-------AR 1017
Query: 379 YNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDT 438
Y + ++ + ++ QN+ + T++ + + REEN
Sbjct: 1018 YERATSETKTKHEEILQNL---------------QKTLLDTEDKLKGAREENSGLLQELE 1062
Query: 439 EYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVS-QDENQSEISLSKTLSLDKEVI 497
E R++ +K + + E D +Q+ E+ K + +T+ S +D Q+ L L + +
Sbjct: 1063 ELRKQADKAKAAQTAE---DAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL----DTL 1115
Query: 498 SQGQTSNVTD-NRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTR 556
+ NV + N+ ++++ E K +A++ E + L
Sbjct: 1116 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1175
Query: 557 GLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALE 616
G + ++E + S+LN +K + + + K +L+
Sbjct: 1176 GRSRDEVTSHQKLEEER----SVLNNQLLEMKKRESKFIKDADEEKA----------SLQ 1221
Query: 617 KEITNSDQTKADLDSSLDIKKNPVP------CQKYSLRNSSNVMLDDK---QCKIKQIQL 667
K I+ + + D+ L+ +N V SL + + DK + K+K ++L
Sbjct: 1222 KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1281
Query: 668 LTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVID 707
K+++ + S +D ++ ++S++ +++D
Sbjct: 1282 QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVD 1321
Score = 57.0 bits (136), Expect = 9e-08
Identities = 188/960 (19%), Positives = 364/960 (37%), Gaps = 137/960 (14%)
Query: 9 SSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQ 68
S S +L S S S+ +T LL E Y +I + LK
Sbjct: 310 SPSASSLSSMSSVASSVSSRPSRTGLLT---------ETSSRYARKISGTTALQEALK-- 358
Query: 69 KETLQNQKETLAEQHKEAMAVFKK-----QLQMKMCALEEEKGKYQLATEIKEKEIEGLK 123
E Q+ ++ LAE+ E V K +++ ++ + ++ L E K ++ L+
Sbjct: 359 -EKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK---MDQLR 414
Query: 124 ETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHE 183
++A K L ++ E ++KV ED ++ E + Q L +
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKV-------EDLQFRVEEESITKGDLETQTKLEHARIK 467
Query: 184 KLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLT 243
+LEQ S L +K +A+ +L++ D + V+ + ++ E +L
Sbjct: 468 ELEQ------------SLLFEKTKAD------KLQRELEDTRVATVSEKSRIMELEKDLA 509
Query: 244 IKEQKFQELQERLNM-----ELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQAN 298
++ Q+ EL+ RL +++++ + +EI+ +QE+ + Q L++ A
Sbjct: 510 LRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 299 TEM-EAELKVLKENNQTLERDNELQREKV----KEN------------------EEKFLN 335
E + E+K L + L ++NE + K+ KEN ++
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE 629
Query: 336 LQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQ 395
L+ K LGT EL +I K++ + Q L NQ+ E
Sbjct: 630 LKVSFSKGLGTETAEFAELKTQIEKMR----------LDYQHEIENLQNQQDSER----- 674
Query: 396 NVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEI 455
+ + E K I +K N+ + IR + + D E E+ EI
Sbjct: 675 ---AAHAKEMEALRAKLMKVIKEKENSLEAIRSK--LDKAEDQHLVEMEDTLNKLQEAEI 729
Query: 456 IIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLD--KEVISQGQTSNVTDNRKSVT 513
+ +L++ + NE V+ +Q + + K L LD ++ S+G+ S + R+ +
Sbjct: 730 KVKELEVLQAKC-NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK-SEMKKLRQQLE 787
Query: 514 TEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNK 573
K LE + K+ + + ++ + + V T + E++ K
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET-LEKELQILK 846
Query: 574 TSFNSILNETAHNTYHNNNKDVSE-NEPFKQFRLLPGTREHA------LEKEITNSDQTK 626
F + +E A + + + V++ ++ +QF +L E +E + D+ +
Sbjct: 847 EKF-AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDERE 905
Query: 627 ADLDSSLDIKKNPV-PCQKYSLRNSSNV--MLDD---KQCKIKQIQL-LTKKSECSILLS 679
L + + +N + K S NSS + M D+ K+ ++++QL LTK +E + L
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
Query: 680 KQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKP 739
K D + +++ H L K + + + L
Sbjct: 966 KSIEDMTVKAEQSQQEA--------AKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 1017
Query: 740 NSSPGGKTMCKNMSDMQNSQ------FNNCLGYLENTNVNISHL-HLNNENSHASQAKDV 792
+T K+ +QN Q + G E + + L L + A A+
Sbjct: 1018 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1077
Query: 793 KTAVHM-----KTCTET----EFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNT 843
+ A+ + K TET E + + N +N++ +N+L +N+ + L
Sbjct: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN 1137
Query: 844 EKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPVYMN 903
+K E + + Q + S E + L GRS ++++ K E+ V N
Sbjct: 1138 QKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN 1197
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/524 (20%), Positives = 241/524 (45%), Gaps = 50/524 (9%)
Query: 30 FKTSLLEALEELRMRREAEIHYEEQI---GKII-VETQELKWQKETL----QNQKETLAE 81
FK LL LEE+R R A++ Q G ++ VE Q++ ++E++ N + +
Sbjct: 766 FKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNV 825
Query: 82 QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKK-V 140
+H M +F K ++ + + E EK ++AT ++E + K+ L + + L++K V
Sbjct: 826 KHWPWMKLFFK-IKPLLKSAETEK---EMAT--MKEEFQKTKDELAKSEAKRKELEEKLV 879
Query: 141 SEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLS 200
+ +++K L L + + L E+ I +F L + E E+ E + N L+
Sbjct: 880 TLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEE-EINAELT 938
Query: 201 ALNKKQEAEICSLKKEL-------------KKAASDLIKSKVTCQYKMGEENINLTIKEQ 247
A +K E E LKK++ K A + +K+ + E LT +++
Sbjct: 939 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKK 998
Query: 248 KFQELQERLNMELELNE----KINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEA 303
QE ++ +L+ E +N+ + ++++ +D+ S + ++L + ++E
Sbjct: 999 ALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEG 1058
Query: 304 ELKVLKENNQTLERDNELQREKVKENEEKFLNLQN--EHEKALG-TWKRHAEELNGEINK 360
+LK+ +E+ LE D + E++K+ + ++ LQ+ E E+ LG +++ +EL I +
Sbjct: 1059 DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Query: 361 IKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKY 420
++ E+ + + T K ++ + + E ++ + V + E++ ++ +
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELE-ELSERLEEAGGVTSTQIELNKKREAEFL---- 1173
Query: 421 NTEQEIREENMENFCSDTEYREKEEKKEGSFIEEI-----IIDDLQLFEKSFKNEIDTVV 475
+++ E +++ R+K E+I + L+ + FK EID +
Sbjct: 1174 KLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233
Query: 476 SQDE--NQSEISLSKTLSLDKEVISQ--GQTSNVTDNRKSVTTE 515
S E ++S+ +L K ++ +S+ G+ + + +TT+
Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQ 1277
Score = 77.4 bits (189), Expect = 7e-14
Identities = 161/805 (20%), Positives = 311/805 (38%), Gaps = 104/805 (12%)
Query: 23 FSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQ 82
F ++ + + + E EE+ R E+Q E +EL + E T E
Sbjct: 1105 FQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIEL 1164
Query: 83 HKEAMAVF-KKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVS 141
+K+ A F K + ++ L+ E L + + E L E + LQ K L+K+ S
Sbjct: 1165 NKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE-LGEQIDNLQRVKQKLEKEKS 1223
Query: 142 EMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSA 201
E + ++ + E K + +EK T+ Q + +E++++++ E RL
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRL-- 1281
Query: 202 LNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELE 261
+ + E+ +E + S L +SK Q F + E L +LE
Sbjct: 1282 --QTEAGELSRQLEEKESIVSQLSRSK------------------QAFTQQTEELKRQLE 1321
Query: 262 LNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELK--VLKENNQTLERDN 319
K + H + S +H LLR+Q + E +AEL+ + K N++ +
Sbjct: 1322 EENKAKNALAHALQ-------SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1374
Query: 320 ELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHY 379
+ + + ++ EE E +K L + +EE ++ + + +SL++T +LQ
Sbjct: 1375 KYETDAIQRTEE-----LEEAKKKLAQRLQDSEE---QVEAVNAKCASLEKTKQRLQGEV 1426
Query: 380 NKL------CNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMEN 433
L N DKK +N +V +E T K E + + + +E R + E
Sbjct: 1427 EDLMVDVERANSLAAALDKKQRNFDKV---LAEWKT-KCEESQAELEASLKESRSLSTEL 1482
Query: 434 FCSDTEYRE-----KEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSK 488
F Y E + K+E +E+ I D + ++ K T+ ++++ +I L K
Sbjct: 1483 FKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK----TIHELEKSRKQIELEK 1538
Query: 489 T---LSLDKEVIS----QGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFV-- 539
L+L++ + + + + V +EI KI EKD + K V
Sbjct: 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIA-EKDEEIEQLKRNYQRTVET 1597
Query: 540 ---VLDTAIET--EKIHLERTRGLDVHHTDVNLEVENNKTS-----FNSILNETAHNTYH 589
LD + + E I L++ D++ ++ L N + + S+ + H
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 590 NNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRN 649
++ + E K+ + R + L+ E+ ++ +A L+ + +K
Sbjct: 1658 LDDA-LRGQEDLKEQLAIVERRANLLQAEV---EELRATLEQTERARK-----------L 1702
Query: 650 SSNVMLDDKQCKIKQIQLL-TKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDH 708
+ +LD + ++QLL T+ + K +D +Q+ ++ + S +
Sbjct: 1703 AEQELLDSNE----RVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKK 1758
Query: 709 HVSYAAFSANSKLLLKNSDKNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLE 768
++ AA A L K D + H M K N K + + + + ++
Sbjct: 1759 AITDAAMMAEE--LKKEQDTSAHLERM--KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1814
Query: 769 NTNVNISHLHLNNENSHASQAKDVK 793
I L E + VK
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVK 1839
Score = 63.2 bits (152), Expect = 1e-09
Identities = 96/505 (19%), Positives = 217/505 (42%), Gaps = 60/505 (11%)
Query: 8 ESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQI----------GK 57
ES + S +L K + EAL++L + + E++I GK
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Query: 58 IIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEK 117
I E ++ + Q E L+ LA + EA A+ ++ ++ LE + K ++ +I EK
Sbjct: 1523 TIHELEKSRKQIE-LEKADIQLALEEAEA-ALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580
Query: 118 --EIEGLKETL-KALQVSKYSLQKKVSEMEQKVQLHLLAKEDYH----------KQLSEI 164
EIE LK + ++ + +L +V + ++L + D + +Q +E
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAET 1640
Query: 165 EKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQ---EAEICSLKKELKKAA 221
K+ ++ GQ +K+ L+ +R ++L+ + ++ +AE+ +EL+
Sbjct: 1641 LKHLRSVQGQ---LKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV----EELRATL 1693
Query: 222 SDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDII 281
+++ + ++ + N ++ Q L + + +K+ ++ +Q E +D
Sbjct: 1694 EQTERARKLAEQELLDSN-------ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 282 ISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHE 341
++ ++ ++ I M ELK ++ + LER + + VK+ + + L +
Sbjct: 1747 RDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR---LDEAEQ 1803
Query: 342 KALGTWKRHAEELNGEINKIKNELSSLKETH---IKLQEHYNKLCNQKTFEEDKKFQNVP 398
AL K+ ++L I +++ EL ++ + +K Y + + T++ ++ +NV
Sbjct: 1804 LALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Query: 399 EVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYR----EKEEKKEGSFIEE 454
+ + ++ + ++ Y + E +E T++R E EE +E + I E
Sbjct: 1864 RLQDLVDKLQVK------VKSYKRQAEEADEQANAHL--TKFRKAQHELEEAEERADIAE 1915
Query: 455 IIIDDLQLFEKSFKNEIDTVVSQDE 479
++ L+ + F + V +E
Sbjct: 1916 SQVNKLRAKTRDFTSSRMVVHESEE 1940
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 85.1 bits (209), Expect = 3e-16
Identities = 109/439 (24%), Positives = 202/439 (46%), Gaps = 49/439 (11%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
L E + RE E +EQ K+ + ++++ Q+E + Q+E L EQ K+ ++ + K
Sbjct: 337 LREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM-----REQEQK 391
Query: 98 MCALEEEKGKYQLATEIKEKEIEGLKETLKAL-QVSKYSLQKKVSEMEQKVQLHLLAKED 156
M ++E+ ++ ++EKE E ++E K QV K +KK+ E E+K + K
Sbjct: 392 M--RDQEERMWEQDERLREKE-ERMREQEKMWEQVEKMREEKKMQEQEKKTR-DQEEKMQ 447
Query: 157 YHKQLSEIEKYYATITGQFGLVKENHEKLEQNVRE----------AIQSNKRLSALNKKQ 206
+++ E EK +E +K E+N+ E + ++L K Q
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Query: 207 EAEICSLKKELKKAASDLI---KSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELN 263
E E ++E K + + + K+ Q KM E+ + +E+K ++ ++++ + E
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
Query: 264 EKINEE---ITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNE 320
EK +E T QEEK + ++ +R++ + E E +++ +E Q E
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627
Query: 321 LQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKE-----THIKL 375
Q EK++E EEK + + EK W++ EE E ++ + L E K+
Sbjct: 628 EQEEKMQEQEEK---MWEQEEK---MWEQ--EEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 376 QEHYNKLCNQ-----KTFEEDKKFQNVPEVNNENSEMSTEK---SENTIIQKYNTEQEIR 427
QE K+ Q KT E++KK + ++ E S EK E ++++ + + +
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Query: 428 EENMENFCSDTEYREKEEK 446
EE M+ + E E+EEK
Sbjct: 740 EEKMQE--QEEEMWEQEEK 756
Score = 79.7 bits (195), Expect = 1e-14
Identities = 95/462 (20%), Positives = 203/462 (43%), Gaps = 45/462 (9%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
+EEL R+A ++ + + +ELK + LQ +K LAE K + + K+L+ K
Sbjct: 199 IEELTKERDA---LSLELYRNTITNEELKKKNAELQ-EKLPLAESEKSEIQLNVKELKRK 254
Query: 98 M------------CALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQ 145
+ L+EE + + +EK+I +E + + + K+ E E+
Sbjct: 255 LERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE 314
Query: 146 KVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNK- 204
K+ + K+L E EK + Q L ++ + EQ + Q K K
Sbjct: 315 KMWRQEKRLREQEKELREQEK---ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
Query: 205 -KQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQ------ERLN 257
+QE + +K++++ + + +M E++ L KE++ +E + E++
Sbjct: 372 WRQEERLWEQEKQMREQEQKMRDQ----EERMWEQDERLREKEERMREQEKMWEQVEKMR 427
Query: 258 MELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLER 317
E ++ E+ E+ T QEEK + ++ +R++ + E E +++ +E N +
Sbjct: 428 EEKKMQEQ--EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK-QEENMWEQE 484
Query: 318 DNELQREKVKENEEKFLNLQNEHEKALGTWK-----RHAEELNGEINKI------KNELS 366
+ E Q++++ E +EK + E+ W+ R EE+ G+ K+ + +
Sbjct: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Query: 367 SLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEI 426
+ E K+++ K+ +Q+ E K + + ++ +M E+ +K E+E+
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604
Query: 427 REENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFK 468
E E E +++E+K E++ + +++E+ K
Sbjct: 605 MREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Score = 77.8 bits (190), Expect = 5e-14
Identities = 95/433 (21%), Positives = 192/433 (44%), Gaps = 48/433 (11%)
Query: 34 LLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQ 93
L E +++R + E EE++ + + +++ Q+E + Q++ L EQ KE
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLRE---QEGKMREQEEKMWRQEKRLREQEKE-------- 329
Query: 94 LQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLA 153
L E++ + + E++E+E E ++ + + ++K+ E E+K+
Sbjct: 330 -------LREQEKELREQKELREQE-----EQMQEQEEKMWEQEEKMREQEEKMWRQEER 377
Query: 154 KEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSAL---NKKQEAEI 210
+ KQ+ E E+ + E + E+ +RE + +++ + K QE E
Sbjct: 378 LWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEK 437
Query: 211 CSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEI 270
+ +E K + I+ + + KM EE + +E+K Q+ +E NM + ++ ++
Sbjct: 438 KTRDQEEKMQEEERIRER---EKKMREEEETMREQEEKMQKQEE--NMWEQEEKEWQQQR 492
Query: 271 THIQEEKQDIIISFQHMQQLLRQQ---IQANTEMEAELKVLKENNQTLERDNEL--QREK 325
Q+EK Q ++ + +Q I+ EM + K + + E+++++ Q EK
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552
Query: 326 VKENEEKFLNLQNEHEKAL-----GTW-----KRHAEELNGEINKIKNELSSLKETHIKL 375
+++ E+K + + EK TW R E + K++ E ++E K+
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 612
Query: 376 QEHYNKLCNQ--KTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMEN 433
QE K+ Q K +E+++K Q E E E E+ E Q+ EQ+ + E
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 434 FCSDTEYREKEEK 446
+ +E+EEK
Sbjct: 673 MQEQEKMQEQEEK 685
Score = 73.9 bits (180), Expect = 7e-13
Identities = 93/422 (22%), Positives = 196/422 (46%), Gaps = 36/422 (8%)
Query: 39 EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKM 98
+E RMR + ++ EQ+ K+ E + + +K+T ++Q+E + E+ + K + + +
Sbjct: 409 KEERMREQEKMW--EQVEKMREEKKMQEQEKKT-RDQEEKMQEEERIREREKKMREEEET 465
Query: 99 CALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYH 158
+EEK + Q +++E E ++ L Q K Q+K+ E E+K+ D
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQRLPE-QKEKLWEQEKMQEQEEKIWEQEEKIRDQE 524
Query: 159 KQLSEIEKYYAT--ITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKE 216
+ + +K + + Q + E EK+ ++ +R+ K QE E + +E
Sbjct: 525 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERME--KKTQEQEKKTWDQE 582
Query: 217 LKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEE 276
K + ++ + + KM EE + +E+K QE +E++ E EK+ E+ +QE+
Sbjct: 583 EKMREEERMRER---EKKMREEEEMMREQEEKMQEQEEKMQ---EQEEKMWEQEEKMQEQ 636
Query: 277 KQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNL 336
++ + ++ +++ Q+ +M + ++ ++ + E + ++EK++E EEK
Sbjct: 637 EEKM---WEQEEKMWEQE----EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
Query: 337 QNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ--KTFEEDKKF 394
+ +K + E+ + K++ E S++E K++E + Q K E+++K
Sbjct: 690 EKMEKKT-----QEQEKKTWDQEKMREE-ESMREREKKMREEEEMMREQEEKMQEQEEKM 743
Query: 395 QNVPEVNNENSEMSTEKSENTIIQKYNTEQ-------EIREENMENFCSDTEYREKEEKK 447
Q E E E E+ E Q+ EQ E +E + + + + R++EEK
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803
Query: 448 EG 449
G
Sbjct: 804 RG 805
Score = 73.6 bits (179), Expect = 1e-12
Identities = 89/433 (20%), Positives = 194/433 (44%), Gaps = 37/433 (8%)
Query: 39 EELRMRREAEIHYEEQIGKI----IVETQELKWQKETLQNQKETLAEQHK-----EAMAV 89
+E +M+++ E +E++ + + E +E W++E +Q Q+E + EQ + E M
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 528
Query: 90 FKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQL 149
+K++ + E+E ++ +++++E + + + + ++ +KK + E+K++
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQE-QKMWDQEERMEKKTQEQEKKTWDQEEKMRE 587
Query: 150 HLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKL-EQNVREAIQSNKRLSALNKKQEA 208
+E K E E +++E EK+ EQ + Q K K QE
Sbjct: 588 EERMREREKKMREEEE-----------MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636
Query: 209 EICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKE-----QKFQELQERLNMELELN 263
E ++E K + K+ Q ++ E+ L E +K QE +E++ + ++
Sbjct: 637 EEKMWEQEEKMWEQE---EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME 693
Query: 264 EKINEEITHI-QEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQ 322
+K E+ +EK S + ++ +R++ + E E +++ +E Q E + Q
Sbjct: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQ 753
Query: 323 REKVKENEEKFLNLQNEHEKALGTWK----RHAEELNGEINKIKNELSSLKETHIKLQEH 378
EK+ E EEK Q E+ W+ + E++ + K++++ ++ K++
Sbjct: 754 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQ 813
Query: 379 YNKLCNQ--KTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCS 436
K+ Q K + +++K E E + E + E+++RE+ +
Sbjct: 814 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ 873
Query: 437 DTEYREKEEKKEG 449
+ + RE+EEK G
Sbjct: 874 EEKMREQEEKMRG 886
Score = 71.2 bits (173), Expect = 5e-12
Identities = 83/416 (19%), Positives = 195/416 (46%), Gaps = 36/416 (8%)
Query: 36 EALEELRMRREAEIHYEEQIGKIIVET----QELK-WQKETLQNQKETLAEQHK----EA 86
E L E +E E EQ KI + QE K W++E ++ Q++ + EQ + +
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Query: 87 MAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQK 146
++ ++ +M+ E+EK + E K +E E ++E K ++ + ++++ +M+++
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWD--QEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 147 VQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVR-----EAIQSNKRLSA 201
+ +E +Q ++++ + Q + E EK+ + R E + ++++
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 675
Query: 202 LNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELE 261
K QE E ++E + + + K Q KM EE ++ +E+K +E +E + E
Sbjct: 676 QEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE-SMREREKKMREEEEMMR---E 731
Query: 262 LNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNEL 321
EK+ E+ +QE+++++ ++ +++ Q+ +M + ++ ++ + E +
Sbjct: 732 QEEKMQEQEEKMQEQEEEM---WEQEEKMWEQE----EKMWEQQRLPEQKEKLWEHEKMQ 784
Query: 322 QREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK 381
++EK+ E EEK ++++ EK G E++ G+ K++ + + K+ K
Sbjct: 785 EQEKIWEQEEK---MRDQEEKMRG----QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEK 837
Query: 382 LCNQ--KTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFC 435
+ Q K + +++K + + E EK + E+++R + + +C
Sbjct: 838 MWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYC 893
Score = 56.6 bits (135), Expect = 1e-07
Identities = 86/369 (23%), Positives = 158/369 (42%), Gaps = 46/369 (12%)
Query: 95 QMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQL----H 150
Q L+EEK E +EIE T++ L K L+ + + + +
Sbjct: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Query: 151 LLAKEDYHKQLSEIEKYYATITGQFGLV----KENHEKLEQNVREAIQSNKRLSAL---N 203
L ++ LS+ + L+ K+ +L + A + + LSA+ +
Sbjct: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
Query: 204 KKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELN 263
KK + I L KE + +L ++ +T EE ++K ELQE+L L +
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTIT-----NEE------LKKKNAELQEKL--PLAES 239
Query: 264 EKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANT---EMEAELKVLKENNQTLERDNE 320
EK +E +++E K+ + + L Q+Q NT EM + + L+E + + + E
Sbjct: 240 EK-SEIQLNVKELKRKL-----ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 321 ---LQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQE 377
Q E+++E E K E E+ + ++ E E+ + + EL KE ++ QE
Sbjct: 294 KMWRQEERLREQEGK----MREQEEKMWRQEKRLREQEKELREQEKELREQKE--LREQE 347
Query: 378 HYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSD 437
+ +K +E+++K + E E E+ + Q EQ++R++ + D
Sbjct: 348 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK----QMREQEQKMRDQEERMWEQD 403
Query: 438 TEYREKEEK 446
REKEE+
Sbjct: 404 ERLREKEER 412
Score = 39.7 bits (91), Expect = 0.016
Identities = 51/249 (20%), Positives = 108/249 (43%), Gaps = 40/249 (16%)
Query: 15 LQSSSETLFSIQLLDFKTSLLE--ALEELRMRREAEIHYEEQIGKIIVETQELKWQKETL 72
+Q E ++ + ++ KT E ++ +MR E + E+ K+ E + ++ Q+E +
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK--KMREEEEMMREQEEKM 736
Query: 73 QNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVS 132
Q Q+E + EQ +E + + KM EE+ + Q E KEK E
Sbjct: 737 QEQEEKMQEQEEEMW-----EQEEKMWEQEEKMWEQQRLPEQKEKLWEH----------E 781
Query: 133 KYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREA 192
K Q+K+ E E+K+ ++ K + EK + GQ ++ EK+ +
Sbjct: 782 KMQEQEKIWEQEEKM------RDQEEKMRGQEEK----MRGQEEKMRGQEEKMWGQEEKM 831
Query: 193 IQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQEL 252
+++ +K + ++++++ + KM E+ + +E+K +E
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQ-----------EEKMREQEEKMRGQEEKMREQ 880
Query: 253 QERLNMELE 261
+E++ + E
Sbjct: 881 EEKMRGQEE 889
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 84.7 bits (208), Expect = 4e-16
Identities = 83/386 (21%), Positives = 179/386 (46%), Gaps = 24/386 (6%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
+EEL R+A ++ + + +ELK + LQ +K L E K + + K+L+ K
Sbjct: 183 IEELTKERDA---LSLELYRNTITDEELKEKNAKLQ-EKLQLVESEKSEIQLNVKELKRK 238
Query: 98 MCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDY 157
+ E+ K L + + E + L + L+++ LQ +V E E +L+ +E
Sbjct: 239 L-----ERAKLLLPQQQLQAEADHLGKELQSVSAK---LQAQVEENELWNRLNQQQEEKM 290
Query: 158 HKQLSEIEKYYATITGQFGLVKENHEKL---EQNVREAIQSNKRLSALNKKQEAEICSLK 214
+Q +I++ I Q ++E EK+ E+ + E + +R + ++E +I L+
Sbjct: 291 WRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 350
Query: 215 KEL-------KKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKIN 267
+++ ++ + K+ Q K E+ + +E+K +E +E++ + E+ ++
Sbjct: 351 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQE 410
Query: 268 EEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVK 327
E++ +E+ + Q ++ +R+Q + E E +++ +E + E + Q EK+
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG 470
Query: 328 ENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ-- 385
E E K + + ++ +R E++ + KI+ + ++E +QE K+ Q
Sbjct: 471 EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 530
Query: 386 KTFEEDKKFQNVPEVNNENSEMSTEK 411
K E+++K Q E E E+
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQ 556
Score = 79.0 bits (193), Expect = 2e-14
Identities = 104/457 (22%), Positives = 200/457 (43%), Gaps = 62/457 (13%)
Query: 76 KETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYS 135
++ + QH+EA+ + + L +K + Q+A + ++ L+ + L +
Sbjct: 98 EQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 157
Query: 136 LQKKVSEMEQKVQLHLLAKEDYHKQLSEIEK---------YYATITGQFGLVKENHEKLE 186
K E+EQ + K+ + + E+ K Y TIT + +KE + KL+
Sbjct: 158 SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE--LKEKNAKLQ 215
Query: 187 QNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYK-MGEENINLTIK 245
+ + + ++S K LN K+ LK++L++A L + ++ + +G+E +++ K
Sbjct: 216 EKL-QLVESEKSEIQLNVKE------LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268
Query: 246 EQ---KFQELQERLNMELE-----LNEKINEEITHIQEEKQDIIISFQHM---------- 287
Q + EL RLN + E EKI E IQE+++ I + M
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK 328
Query: 288 QQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTW 347
++ +R+Q + E E +++ L+E E+ E +E+ ++ EEK + E+ W
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMW 386
Query: 348 KRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ----------------KTFEED 391
R E++ + KI+ + ++E K+ E K+ Q K E++
Sbjct: 387 -RQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445
Query: 392 KKFQNVPEVNNENSEMSTEKSENTIIQKYN-TEQEIREENMENFCSDTEYREKEEKKEGS 450
KK + E E EM E+ E Q+ EQE + + E E + +E++K+
Sbjct: 446 KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIR 505
Query: 451 FIEEIIIDDLQLF----EKSFKNEIDTVVSQDENQSE 483
EE I + ++ EK ++ E + + Q+E E
Sbjct: 506 EQEEKIREQEEMMQEQEEKMWEQE-EKMCEQEEKMQE 541
Score = 70.9 bits (172), Expect = 6e-12
Identities = 71/342 (20%), Positives = 161/342 (47%), Gaps = 34/342 (9%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKW-QKETLQNQKETLAEQHKEAMAVFKKQLQM 96
L+ + + +A++ E ++ + +E W Q+E +Q ++E + EQ ++ +K +
Sbjct: 262 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQ 321
Query: 97 KMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKED 156
+ E+E+ + + EKE E ++ L+ K Q+K+ E E+K Q +E
Sbjct: 322 EEMMWEKEEKMRRQEEMMWEKE-----EKIRELE-EKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 157 YHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKE 216
+Q E A + Q ++E EK+ + + +++ +QE ++ ++E
Sbjct: 376 EKRQEQE-----AKMWRQEEKIREQEEKIREQEEMMQEQEEKMG----EQEEKMWEQEEE 426
Query: 217 LKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEE 276
+++ + + + K+ E+ + +E+K +E +E + E EK+ E+ + E+
Sbjct: 427 MQEQEEKMRRQ----EEKIREQEKKIREQEEKIREQEEMMQ---EQEEKMGEQEGKMCEQ 479
Query: 277 KQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNL 336
+ + Q ++ +R+Q + E E +++ +E + E + Q EK+ E EEK
Sbjct: 480 EAKM----QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC-- 533
Query: 337 QNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEH 378
E E+ + + E++ + K++ + L++ K+QEH
Sbjct: 534 --EQEEKM---QEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 53.5 bits (127), Expect = 1e-06
Identities = 48/217 (22%), Positives = 105/217 (48%), Gaps = 18/217 (8%)
Query: 36 EALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQ 95
E + E R+E E Q KI + ++++ Q+E +Q Q+E + EQ +E M ++++Q
Sbjct: 370 EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQ-EEKMWEQEEEMQ 428
Query: 96 MKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKV-QLHLLAK 154
+ EE+ + + +EK+I +E ++ + ++K+ E E K+ + +
Sbjct: 429 EQ----EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ 484
Query: 155 EDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLK 214
E K + EK I Q ++E EK+ + + +++ +QE ++C +
Sbjct: 485 EQEEKMRRQEEK----IREQEKKIREQEEKIREQEEMMQEQEEKM----WEQEEKMCEQE 536
Query: 215 KELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQE 251
+++++ + + + KM E+ + L +E+K QE
Sbjct: 537 EKMQEQEEKMRRQ----EEKMREQEVRLRQQEEKMQE 569
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 84.3 bits (207), Expect = 5e-16
Identities = 139/657 (21%), Positives = 261/657 (39%), Gaps = 105/657 (15%)
Query: 39 EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKM 98
EEL RE ++ E ++ ++ +L +K LQ Q + E EA + + +L K
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL-RARLTAKK 910
Query: 99 CALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEME---QKVQLHLLAKE 155
LEE + E +E+ + L+ K +Q + L++++ E E QK+QL + E
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 156 DYHKQLSE----IEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEIC 211
K+L E +E + + L+++ + N+ E + +K L+ L K EA I
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 212 SLKKELKKA-----------------ASDLIKSKVTCQYKMGEENINLTIKEQKFQELQE 254
L++ L++ ++DL Q ++ E + L KE++ Q
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 255 RL-------NMELELNEKINEEITHIQE--------------EKQDIIISFQHMQQLLRQ 293
R+ NM L+ ++ +I+ +QE +K+D+ + ++ L
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 294 -------QIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGT 346
Q + ++ E E+ +LK +TLE + + +++E +K E + L
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILK---KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 347 WKRHAEELNGEINKIKNELSSL-KETHIKLQ-----EHYNKLCNQKTFEEDKKFQNVPEV 400
KR L ++NE L E + LQ EH K + E KF
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKF------ 1261
Query: 401 NNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDL 460
NE + TE ++ T+ ++ +N+ S ++ + + K+ S +E + D
Sbjct: 1262 -NEGERVRTELADKV------TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314
Query: 461 QLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKI 520
+L Q+EN+ ++SLS L K+V + + R+ + E + K
Sbjct: 1315 ELL-------------QEENRQKLSLSTKL---KQVEDEKNSF-----REQLEEEEEAKH 1353
Query: 521 CLEKDNGCTEF------KSPNNHFVVLDTAIETEKIHLERTRGLDVHHTD---VNLEVEN 571
LEK K + L+TA E ++ + GL H + ++E
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 572 NKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKAD 628
KT L++ + H + + K+F L + K D+ +A+
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470
Score = 63.9 bits (154), Expect = 8e-10
Identities = 106/551 (19%), Positives = 219/551 (39%), Gaps = 121/551 (21%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQ--------------KET 71
Q+ D K S E LEE EA+ + E+QI + + ++K + K
Sbjct: 1333 QVEDEKNSFREQLEE---EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK 1389
Query: 72 LQNQKETLAEQHKEAMAVFKK------QLQMKM--------------CALEEEKGKY--- 108
LQ E L+++H+E +A + K +LQ ++ C LE+++ K+
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449
Query: 109 ---------QLATEIKEKEIEGLKETLKALQVSKYSLQKKVSE-MEQKVQLHLL------ 152
+ A E E E ++ KAL SL + + E MEQK +L L
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKAL-----SLARALEEAMEQKAELERLNKQFRT 1504
Query: 153 -------AKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKR----LSA 201
+K+D K + E+EK + Q +K E+LE ++ + R L A
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 202 LNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELE 261
+ + E ++ ++ ++ L++ + ++ +E ++Q+ + R +E++
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE------RKQRSMAVAARKKLEMD 1618
Query: 262 LNE--------------------KINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEM 301
L + K+ ++ E D S + + ++ + M
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 302 EAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKR-------HAEEL 354
EAE+ L+E ER +++ E ++ N + AL +R EEL
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 355 NGEINKIKNELSSLKETHIKLQEHYNKLCNQKTF-EEDKKFQNVPEVNNENSEMSTEKSE 413
E + LK+ ++++ + L +++ ++++ + E N+ ++ ++ E
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME 1798
Query: 414 NTIIQKYNT------------EQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQ 461
T+ KY E+++ E E + + R E+K + ++ +DD +
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ---VDDER 1855
Query: 462 LFEKSFKNEID 472
+ +K++ D
Sbjct: 1856 RNAEQYKDQAD 1866
Score = 63.5 bits (153), Expect = 1e-09
Identities = 84/422 (19%), Positives = 189/422 (44%), Gaps = 45/422 (10%)
Query: 27 LLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEA 86
L+ K + +++ EL + A E+Q+ ++ + +EL+ + + ++ K L +
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRA---LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 87 MAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQK 146
A F++ LQ + EE+K + E E+E ++ ++ L+ + ++E
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 147 VQLHLLAKEDYHKQL-----------SEIEKYYATITGQFGLVKENHEKLEQNVREAIQS 195
+ +++ KQL E++ A+ KEN +KL+ E IQ
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685
Query: 196 NKRLSALNK-KQEA---------EICSLK-------KELKKAASDLIKSKVTCQYKMGE- 237
+ L+A + K++A EI + +E ++ + + + + + + G
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 238 ENINLTIKEQKFQ--ELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQI 295
E IN +K+ Q ++ LN+E +K ++ + +++ + Q M+ ++ +
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY 1805
Query: 296 QAN-TEMEAELKVLKE--NNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAE 352
+A+ T +EA++ L+E +N+T ER ++ + E + K + LQ + E +R+AE
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE------RRNAE 1859
Query: 353 ELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNE-NSEMSTEK 411
+ + +K L LK + +E + N + ++ ++ E + N E+S+ K
Sbjct: 1860 QYKDQADKASTRLKQLKRQLEEAEEEAQR-ANASRRKLQRELEDATETADAMNREVSSLK 1918
Query: 412 SE 413
++
Sbjct: 1919 NK 1920
Score = 48.5 bits (114), Expect = 3e-05
Identities = 78/385 (20%), Positives = 160/385 (41%), Gaps = 46/385 (11%)
Query: 291 LRQQIQANTEMEAELKVLKEN----NQTLERDNELQREKVKENEEKFLNLQNEHEKALGT 346
L++Q+QA TE+ AE + L+ Q LE +V+E EE+ +LQ E +K
Sbjct: 885 LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQN 944
Query: 347 WKRHAEELNGE--------INKIKNE--LSSLKETHIKLQEHYNKLCNQKTFEEDKKFQ- 395
+ E+L E + K+ E L L+E I L++ KL +K ED+ +
Sbjct: 945 IQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
Query: 396 --NVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIE 453
N+ E ++ ++ K+++ + + E+ +R E + E + K EG +
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAMIT-DLEERLRREEKQR----QELEKTRRKLEGDSTD 1059
Query: 454 EIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVT 513
+ D + + E+ +++ E + + +L++ +++E + +S
Sbjct: 1060 --LSDQIAELQAQIA-ELKMQLAKKEEELQAALAR---VEEEAAQKNMALKKIRELESQI 1113
Query: 514 TEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNK 573
+E+++ + E+ + K + L +E K LE T + T E+ + +
Sbjct: 1114 SELQEDLESERASRNKAEKQKRD----LGEELEALKTELEDT----LDSTAAQQELRSKR 1165
Query: 574 TSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSL 633
+IL +T + + E + A+E+ +QTK + ++L
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQE---------MRQKHSQAVEELAEQLEQTKR-VKANL 1215
Query: 634 DIKKNPVPCQKYSLRNSSNVMLDDK 658
+ K + ++ L N V+L K
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGK 1240
Score = 34.7 bits (78), Expect = 0.50
Identities = 61/330 (18%), Positives = 130/330 (39%), Gaps = 60/330 (18%)
Query: 270 ITHIQEEKQ----DIIISFQHMQQ--LLRQQIQANTEMEAELKVLKENNQTLERDNELQR 323
+ H++EE+ D+II FQ + L R+ + +KVL+ N
Sbjct: 768 LAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAA--------- 818
Query: 324 EKVKENEEKFLNLQNEHEKALGTWKRHAEELNG--EINKIKNELSSLKETHIKLQEHYNK 381
+L L+N W R ++ ++++ + E+ + +E +K++E
Sbjct: 819 ---------YLKLRNWQ------WWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLA 863
Query: 382 LCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYR 441
N+ T E + Q + E ++ E ++ +++ +E C D E R
Sbjct: 864 AENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEAR 923
Query: 442 EKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDK------- 494
+EE++ LQ +K + I + +++ + E S + L L+K
Sbjct: 924 VEEEEER--------CQHLQAEKKKMQQNIQEL--EEQLEEEESARQKLQLEKVTTEAKL 973
Query: 495 ------EVISQGQTSNVTDNRKSVTTEIKD---KICLEKDNGCTEFKSPNNHFVVLDTAI 545
++I + Q + +K + I + + E++ + K N H ++ T +
Sbjct: 974 KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI-TDL 1032
Query: 546 ETEKIHLERTRGLDVHHTDVNLEVENNKTS 575
E E++ E + ++ T LE ++ S
Sbjct: 1033 E-ERLRREEKQRQELEKTRRKLEGDSTDLS 1061
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 84.0 bits (206), Expect = 7e-16
Identities = 174/883 (19%), Positives = 346/883 (39%), Gaps = 83/883 (9%)
Query: 8 ESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKW 67
+++S+F SSS L QL L + EL +R + H +E G++ + QEL+
Sbjct: 265 DANSSFFDNSSSPHLLD-QLKAQNQELRNKINELELRLQG--HEKEMKGQVN-KFQELQL 320
Query: 68 QKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLK 127
Q L+ K L E+ K + + +L ++ KY + +K E L +
Sbjct: 321 Q---LEKAKVELIEKEK-VLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQ 376
Query: 128 ALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQ 187
+ ++ SL++K+ E E++ Q ++LS ++ + T+ + +K +L Q
Sbjct: 377 NAESARCSLEQKIKEKEKEFQ----------EELSRQQRSFQTLDQECIQMKA---RLTQ 423
Query: 188 NVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQ 247
+++A + L A K + L+ L++ L +++ Q +EN +
Sbjct: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE----LRR 479
Query: 248 KFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKV 307
+E+++ N+ +E+ E+ H++ E ++I Q + NT E L+
Sbjct: 480 SMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539
Query: 308 LKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSS 367
L+E + +++N L EK+K ++ + L + H E+LN +++K + E +
Sbjct: 540 LQE--KINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
Query: 368 LKETHIKLQEHYNKLCNQKTF-----EEDKKFQNVPEVNNENSEMSTEKSENTI----IQ 418
L ++ Y +L +KT E++K E EN + E + I+
Sbjct: 598 LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIK 657
Query: 419 KYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQD 478
+ + +R M+ E R + + E+ L E K E S
Sbjct: 658 SHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV-EVETQKLAYMELQQKAEF----SDQ 712
Query: 479 ENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHF 538
++Q EI + + L ++ GQ ++ + ++ EI DK +D E++S +
Sbjct: 713 KHQKEI---ENMCLKTSQLT-GQVEDLEHKLQLLSNEIMDKDRCYQDLH-AEYESLRDLL 767
Query: 539 VVLDTAIETEKIHLERTRGLD----VHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKD 594
D ++ T + H D +HH+ N+ E + N+
Sbjct: 768 KSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
Query: 595 VSENEPFKQFRLLPGTREHA-LEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNV 653
+ +F L + ++ L+K+ Q K +++ +L K Q + S +
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENL--MKAEQMHQSFVAETSQRI 885
Query: 654 ----------------MLDDKQCKIKQIQLLTKKSEC----------SILLSKQTSDFLQ 687
L + K K++QLL K E S L + + LQ
Sbjct: 886 SKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ 945
Query: 688 VCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKPNSSPGG-K 746
+ ++TL + + I ++ N L N+ N M+++ K S
Sbjct: 946 LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID 1005
Query: 747 TMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHASQAKDVKTAVHMKTCTETEF 806
K++S++ + L L+ + ++ A+Q K+ K + CT
Sbjct: 1006 EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL-C 1064
Query: 807 SNKKNQIDENQVTEATKNDLFL--FVSINERQHTLLNNTEKTE 847
N+KN++++ + A ++ FL ER L+ E +
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ 1107
Score = 76.6 bits (187), Expect = 1e-13
Identities = 120/524 (22%), Positives = 229/524 (43%), Gaps = 91/524 (17%)
Query: 34 LLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQ 93
L ++E+LR R EA+ E++ ++ + +E + + L+ + E L + + A +
Sbjct: 2299 LRNSIEKLRARLEAD---EKKQLCVLQQLKESEHHADLLKGRVENLERELEIA------R 2349
Query: 94 LQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLA 153
+ ALE E K ++ T +K K IEG+ ++L+ L++ +++ + + ++Q
Sbjct: 2350 TNQEHAALEAENSKGEVET-LKAK-IEGMTQSLRGLELDVVTIRSEKENLTNELQ----K 2403
Query: 154 KEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQS-----NKRLSALNKKQEA 208
+++ +L I + I + K ++ E +Q+ N+R++AL+ QEA
Sbjct: 2404 EQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEA 2463
Query: 209 EICSLKK----------ELKKAASDLIKSKVTCQYKMGEENINLTIKE-----QKFQELQ 253
C K+ EL+KA + Y + + ++N I+E QK ++
Sbjct: 2464 --CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
Query: 254 E---RLNMELELNEKINEEITHIQEEKQ---DIIISFQHMQQLLRQQIQA----NTEMEA 303
E RL +++ E++ +++ ++ E Q + + +++ L Q+IQ N ++
Sbjct: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQD 2581
Query: 304 ELKVLKENNQTLERDNELQR-------EKVKENEEKFLNLQNE-HEKALGTWKRHAEELN 355
L+VL+ + + LE + EL + EKV + K LQ E HE A T + EEL+
Sbjct: 2582 TLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ-EELS 2640
Query: 356 GEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENT 415
GE N++ EL L E E + E+ ENSE+ K
Sbjct: 2641 GEKNRLAGELQLLLE------------------EIKSSKDQLKELTLENSEL---KKSLD 2679
Query: 416 IIQKYNTEQE--IREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDT 473
+ K E+E +REE E E E+K + ++ K ++ EI T
Sbjct: 2680 CMHKDQVEKEGKVREEIAE---YQLRLHEAEKKHQALLLDT---------NKQYEVEIQT 2727
Query: 474 VVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIK 517
+ ++ E S+ L +D S+ + +N + E+K
Sbjct: 2728 YREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2771
Score = 71.6 bits (174), Expect = 4e-12
Identities = 114/498 (22%), Positives = 223/498 (44%), Gaps = 66/498 (13%)
Query: 6 NTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGK-IIVETQE 64
N S F+L+S + +Q E L +++ E + EQ+ + + ET +
Sbjct: 830 NRVDSLEFSLESQKQMNSDLQ------KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQ 883
Query: 65 L--KWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGL 122
K Q++T +Q + + A+ +K+LQ+ +E E+ + Q E+K K L
Sbjct: 884 RISKLQEDTSAHQN--VVAETLSALENKEKELQLLNDKVETEQAEIQ---ELK-KSNHLL 937
Query: 123 KETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENH 182
+++LK LQ+ +L + EM + L+ EIE+ +T + G +KE +
Sbjct: 938 EDSLKELQLLSETLSLEKKEMSSIISLNK----------REIEE----LTQENGTLKEIN 983
Query: 183 EKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINL 242
L Q IQ ++ + ++E I L + K+ L++ C+ + G +L
Sbjct: 984 ASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQR---CE-ETGNAYEDL 1039
Query: 243 TIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEME 302
+ QK++ QE+ N +LE + E T + E +++ ++QL + + E
Sbjct: 1040 S---QKYKAAQEK-NSKLEC---LLNECTSLCENRKN------ELEQLKEAFAKEHQEFL 1086
Query: 303 AELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIK 362
+L +E NQ L + E ++ ++ + + QN + G K+ L E NK++
Sbjct: 1087 TKLAFAEERNQNLMLELETVQQALRS---EMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQ 1143
Query: 363 NELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNT 422
E++ L LQE+ + KT E + ++ P + N E +E+++ K
Sbjct: 1144 KEVNDL------LQENEQLMKVMKTKHECQNLESEP-IRNSVKERESERNQCNF--KPQM 1194
Query: 423 EQEIREENMENFCS-----DTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQ 477
+ E++E +++++ + + R KE K + S E+ + LQ ++ + +++T Q
Sbjct: 1195 DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK---ECLQHELQTIRGDLETSNLQ 1251
Query: 478 DENQSEISLSKTLSLDKE 495
D EIS K +D E
Sbjct: 1252 DMQSQEISGLKDCEIDAE 1269
Score = 64.3 bits (155), Expect = 6e-10
Identities = 159/811 (19%), Positives = 303/811 (37%), Gaps = 165/811 (20%)
Query: 57 KIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKE 116
+ + + QEL+ Q + L+ +K+ Q A +KQ Q +E EK + T +K
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQK----VENEKTE---GTNLK- 66
Query: 117 KEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFG 176
+E + L E ++L+ +K + ++ E +V GQ
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQ---------------------EGQLN 105
Query: 177 LVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMG 236
K+ EKLEQ ++ +R + + + K + L S QY G
Sbjct: 106 SGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPS----QYYSG 161
Query: 237 EENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEK--QDIIISFQHMQQLLRQQ 294
K+++L+E+ N E+E +++ E+ +Q +K Q + + + + + R Q
Sbjct: 162 S----------KYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQ 211
Query: 295 IQANT---EMEAELKVLKENNQT--LERD----------------NELQREKVKENEEKF 333
++ + E L N+Q + RD + LQ K N F
Sbjct: 212 ASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFF 271
Query: 334 LNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKK 393
N + H L K +EL +IN+++ ++LQ H ++ Q K
Sbjct: 272 DNSSSPH--LLDQLKAQNQELRNKINELE----------LRLQGHEKEMKGQVN-----K 314
Query: 394 FQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIE 453
FQ + ++ EK++ +I+K E + N C D R + + S
Sbjct: 315 FQEL--------QLQLEKAKVELIEK---------EKVLNKCRDELVRTTAQYDQAS--- 354
Query: 454 EIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVT 513
E+ K + + Q +N S SL++++ + + +R+ +
Sbjct: 355 ----TKYTALEQKLKKLTEDLSCQRQNAE----SARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 514 TEIKDKICLEKDNGCT-EFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENN 572
+ D+ C++ T E + N VL E +K+ T V ++ENN
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQA--ELDKL------------TSVKQQLENN 452
Query: 573 KTSFNSILNETAH----NTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKAD 628
F L + N S E K+ LL E +E+ + + +
Sbjct: 453 LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA-REVCHLEAELKN 511
Query: 629 LDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQ-------------IQLLTKKSECS 675
+ L+ +N K + S ML D Q KI Q + L K+ +CS
Sbjct: 512 IKQCLNQSQNFAEEMK-AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS 570
Query: 676 ILLSKQTSDFLQVCNDTLEKSELTVPC------------DIVIDHHVSYAAFSANSKLLL 723
L K+ ++ ND L K+E + + + ++ + + ++ LL
Sbjct: 571 QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630
Query: 724 KNSDKNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNEN 783
+ ++ + + C +++ ++N + LE N+S N N
Sbjct: 631 TQMESEKENLQSKINHLET------CLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684
Query: 784 SHASQAKDVKTA--VHMKTCTETEFSNKKNQ 812
S++ +V+T +M+ + EFS++K+Q
Sbjct: 685 VLDSKSVEVETQKLAYMELQQKAEFSDQKHQ 715
Score = 63.9 bits (154), Expect = 8e-10
Identities = 135/738 (18%), Positives = 297/738 (40%), Gaps = 106/738 (14%)
Query: 18 SSETLFSIQLLDFKTS-----LLEALEELRMRREAEIHYEEQI-GKIIVETQELKWQKET 71
+ E + ++QL +TS LL +E+ + E+ ++ +++ K+ ++ +L + E
Sbjct: 1765 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA 1824
Query: 72 LQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLK--AL 129
++ + E KE + +K L+ C +E + + + EGL L+ A
Sbjct: 1825 CIELEKIVGELKKENSDLSEK-LEYFSCDHQELLQRVETS--------EGLNSDLEMHAD 1875
Query: 130 QVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHE--KLEQ 187
+ S+ + V+++ + L D +LS I A+I + ++ + E + E+
Sbjct: 1876 KSSREDIGDNVAKVNDSWKERFL---DVENELSRIRSEKASIEHEALYLEADLEVVQTEK 1932
Query: 188 NVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTC----QYKMGEENINLT 243
E NK+ + ++E + + ++ + D + K T KM E+ L
Sbjct: 1933 LCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELE 1992
Query: 244 IKEQK----FQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANT 299
+ + Q + + + EL + ++ +++ + ++K + Q +++ +
Sbjct: 1993 SHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKC 2052
Query: 300 EMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL---GTWKRHAEELNG 356
E+E ++ L + + L +++E + ++ E++ + LN+ E AL G +
Sbjct: 2053 ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQE 2112
Query: 357 EINKIKNELSSLK---ETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSE 413
E+++++ + L+ E K Q H + ++ E D V + E +MS E E
Sbjct: 2113 EVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE-LQMSEENQE 2171
Query: 414 NTIIQKYNTEQEIR----------------EENMENFCSDTEYREKE-EKKEGSFIE--- 453
I+ N++ E+ E ++ S+ E K+ ++K+G E
Sbjct: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231
Query: 454 -----EIIIDDLQLFEKSFKNEIDTVVSQDENQ--------------SEISLSKTLSLDK 494
+ ++++ + E K E T V +NQ EI + SLD
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
Query: 495 EVISQGQTSNVTDN-RKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLE 553
+ + Q N + R + + K ++C+ + K +H +L +E + LE
Sbjct: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCV-----LQQLKESEHHADLLKGRVENLERELE 2346
Query: 554 RTRGLDVHHTDVNLEVENNKTSFNSILNE----------------TAHNTYHN-NNKDVS 596
R H LE EN+K ++ + T + N N+
Sbjct: 2347 IARTNQEH---AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK 2403
Query: 597 ENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLD 656
E E + ++ + E+ L+++ Q K +++++ + + K + + D
Sbjct: 2404 EQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL---KELNERVAALHND 2460
Query: 657 DKQCKIKQIQLLTKKSEC 674
+ CK K+ Q L+ + EC
Sbjct: 2461 QEACKAKE-QNLSSQVEC 2477
Score = 61.6 bits (148), Expect = 4e-09
Identities = 82/398 (20%), Positives = 176/398 (44%), Gaps = 58/398 (14%)
Query: 15 LQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKII--VETQELKWQKETL 72
LQSS L IQ ++ LE +E R + +I +EQ+ + VE + W+++ L
Sbjct: 2499 LQSSVNGL--IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL 2556
Query: 73 QNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVS 132
+ + T+ +L+ K+ L+ + Q E+ + + L+ L+ ++
Sbjct: 2557 ELRNLTV-------------ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD 2603
Query: 133 KYSLQKKVSEMEQKV-----QLHLLAKEDYHKQLSEIEKYYATITGQFGL----VKENHE 183
K S +KV++M K ++H +A++ Q E+ + G+ L +K + +
Sbjct: 2604 KMSFVEKVNKMTAKETELQREMHEMAQKTAELQ-EELSGEKNRLAGELQLLLEEIKSSKD 2662
Query: 184 KLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLT 243
+L++ E + K L ++K Q + +++E+ + L +++ Q + + N
Sbjct: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY- 2721
Query: 244 IKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEA 303
E + Q +E+L + E EI ++ K++ L ++A T++
Sbjct: 2722 --EVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEE-----------LNNSLKATTQILE 2768
Query: 304 ELKVLKENN----QTLERDNELQREKVK---------ENEEKFLNLQNEHEKALGTWKRH 350
ELK K +N L+++NE + K+K E E++ L + +A ++
Sbjct: 2769 ELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKT 2828
Query: 351 AEELNGEINKIKNELSSLKET----HIKLQEHYNKLCN 384
++ +++++ E+ LKET + E+ +K C+
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCS 2866
Score = 49.3 bits (116), Expect = 2e-05
Identities = 196/977 (20%), Positives = 374/977 (38%), Gaps = 174/977 (17%)
Query: 27 LLDFKTSLLEALE-ELRMRREAEI-HYEEQIGKIIV---ETQELKWQKETLQNQKETLAE 81
LL+ TSL E + EL +EA ++E + K+ Q L + ET+Q +
Sbjct: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 82 QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKAL--------QVSK 133
++ L+ ++ L+EE+ K Q +E E L + +K + +
Sbjct: 1116 DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIR 1175
Query: 134 YSLQKKVSEMEQ---KVQLHLLAKE----DYHKQLSEIEKYYATITGQFGLVKENHEKLE 186
S++++ SE Q K Q+ L KE Y+ QL ++E A + + ++E+ ++ E
Sbjct: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLE---AMLRNKELKLQESEKEKE 1232
Query: 187 --QNVREAIQSNKRLSALNKKQEAEICSLKK--------------ELKKAASDLIKSKVT 230
Q+ + I+ + S L Q EI LK EL + +D + +
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292
Query: 231 CQYKMGE----ENINLTIKEQKFQ---ELQERLNMELELNEKINEEITHIQEEKQDIIIS 283
Q M + E I ++ +K++ EL + + + K+ EE+ + E + +
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352
Query: 284 FQHMQQLLRQQI-------QANTEMEAELKVLKENNQ----TLERDNELQREKVKENEEK 332
+ L + I Q N + L L E+N TL D E+Q E +EK
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLS-DKEVQMH-FAELQEK 1410
Query: 333 FLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDK 392
FL+LQ+EH+ +H +++ ++++++ + SLK ++ L + E
Sbjct: 1411 FLSLQSEHKI---LHDQHC-QMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQL 1466
Query: 393 KFQN--VPEVNN----ENSEMST------------EKSENTIIQKYNTEQEIREENM-EN 433
+ VP +++ ++S +S+ + + +++ + ++ E
Sbjct: 1467 GLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEV 1526
Query: 434 FCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEI------SLS 487
FCS + E +KE +++L+ + ++ ++ + + E+Q + L
Sbjct: 1527 FCSSLQ-EENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585
Query: 488 KTLSLDKEVISQGQTSNVTDNRK------SVTTEIKDKICLEK---DNGCTEFKSPNNHF 538
+ LS +++ + + +++N + SVT E++ K+ EK + E +
Sbjct: 1586 QLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQL 1645
Query: 539 VVLDTA------IETEKIHLERTRGLDV--HHTDVNLEVENNKTSFNSILNETAHNTYHN 590
LD + I+TE R D+ HT E K + I ++ A +
Sbjct: 1646 QGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE-RTPKHDVHQICDKDAQQDLNL 1704
Query: 591 NNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDS-------------SLDIKK 637
+ + ++E K G + E D+T+ + +D
Sbjct: 1705 DIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLG 1764
Query: 638 NPVPCQKYSLR--NSSNVMLD----------------------DKQCKIKQIQLLTKKSE 673
N LR +SN L D + ++++QL+TK
Sbjct: 1765 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA 1824
Query: 674 CSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSM 733
C I L K + + +D EK E DH + L NSD +H+
Sbjct: 1825 C-IELEKIVGELKKENSDLSEKLEY-----FSCDHQELLQRVETSEGL---NSDLEMHA- 1874
Query: 734 SMLVKPNSSPGGKTMCKNMSDMQNSQF---NNCLGYLENTNVNISHLHLNNENSHASQAK 790
K + G + K ++D +F N L + + +I H L E
Sbjct: 1875 ---DKSSREDIGDNVAK-VNDSWKERFLDVENELSRIRSEKASIEHEALYLE-------A 1923
Query: 791 DVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNTEKTESLN 850
D++ K C E + NK+ +V + +L + S + L+ K +
Sbjct: 1924 DLEVVQTEKLCLEKDNENKQ------KVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL 1977
Query: 851 DIVSGKMFSEGQLEESH 867
D +S KM + Q ESH
Sbjct: 1978 DQLSEKMKEKTQELESH 1994
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 83.2 bits (204), Expect = 1e-15
Identities = 125/609 (20%), Positives = 265/609 (43%), Gaps = 85/609 (13%)
Query: 17 SSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQK 76
+ +TLF Q+ + KT +++ LE+ + + QEL+ +++ +Q ++
Sbjct: 1928 ADEKTLFERQIQE-KTDIIDRLEQELLCASNRL-------------QELEAEQQQIQEER 1973
Query: 77 ETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIK-EKEIEGLKETLKALQVSKYS 135
E L+ Q KEAM ++ ++ E+ K +L + + EK + L++ +KAL++
Sbjct: 1974 ELLSRQ-KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
Query: 136 LQKKVSEMEQKVQLHLLAKEDYHKQL-SEIEKYYATITGQFGLVKENHEK--LEQNVREA 192
+ E+EQ+ L+ ++ L ++EK + Q + HE+ +Q +++
Sbjct: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ--AIDREHERDVFQQEIQKL 2090
Query: 193 IQSNK---RLSALNKKQEAEICSLKKELKK---AASDLIKSKVTCQYKMGEENINLTIKE 246
Q K R +++ Q E+ L LK+ S+L+ SK Q + E N + E
Sbjct: 2091 EQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLE 2150
Query: 247 QKFQELQERL-------------NMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQ 293
+ +EL++ L EL L ++ E I ++++I + ++Q +
Sbjct: 2151 FRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2210
Query: 294 QIQANTEME---AELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRH 350
N E++ +L++ K+ + T ++ E + + K++ EK L L + A+ T +H
Sbjct: 2211 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK-LGLAIKESDAMSTQDQH 2269
Query: 351 AEELNGEINKI----KNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSE 406
L G+ +I + E+ L E KLQ+ + K EE + + + ++
Sbjct: 2270 V--LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNEL-----IRDLETQ 2322
Query: 407 MSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEK- 465
+ S+ + K N E+EI + N E EK +++ + ++ ++ L E+
Sbjct: 2323 IECLMSDQECV-KRNREEEIEQLN--------EVIEKLQQELANIGQKTSMNAHSLSEEA 2373
Query: 466 -SFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEK 524
S K+++D V+++ L+L+++V + + N T +++ E
Sbjct: 2374 DSLKHQLDVVIAE-----------KLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL 2422
Query: 525 DNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETA 584
+ E +S + + ++ HL + + LEV + + S+ N+T
Sbjct: 2423 FSLKRERESVEKIQSIPENSVNVAIDHLSKDK--------PELEVVLTEDALKSLENQTY 2474
Query: 585 HNTYHNNNK 593
++ N K
Sbjct: 2475 FKSFEENGK 2483
Score = 72.8 bits (177), Expect = 2e-12
Identities = 112/525 (21%), Positives = 228/525 (43%), Gaps = 82/525 (15%)
Query: 24 SIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQH 83
+I+L D + + EEL + E + + Q+ ++ +EL + +E +Q ++T+AEQ
Sbjct: 499 NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLV---EELSFSREQIQRARQTIAEQE 555
Query: 84 KEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEM 143
+ K + +E+ K + A+E KE+E E +V+ Y ++ ++ E
Sbjct: 556 SKLNEAHK-----SLSTVEDLKAEIVSASE-SRKELELKHEA----EVTNYKIKLEMLEK 605
Query: 144 EQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALN 203
E+ L +A+ Q +E+E+ + +HE+ ++E ++ R++
Sbjct: 606 EKNAVLDRMAE----SQEAELERLRTQLL-------FSHEEELSKLKEDLEIEHRINIEK 654
Query: 204 KKQEAEICSLKKELKKAASDLIKSKVTCQYKMGE---ENINLTIKEQKFQELQERL---- 256
K I K+++ +++ + T Q++ + L ++ K ++LQ+ L
Sbjct: 655 LKDNLGI-HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 257 --NMELELNEKINEEITHIQEEKQDIIISFQHMQ------QLLRQQIQAN--------TE 300
M L++NE + +EI +++E+++ Q +Q +LL +Q++ +
Sbjct: 714 SEEMTLQINE-LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 301 MEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL-GTWKRHAE------- 352
+EAE +LK+ +TLE + L+ EE+ + L + K+ W++ E
Sbjct: 773 LEAENSILKDEKKTLE--DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830
Query: 353 -------ELNGEINKIKNELS----SLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVN 401
+LN EI K +N S + + + +LQE Y L K ED K + E
Sbjct: 831 DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890
Query: 402 NE----NSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIII 457
++ N E+ ++ T ++ + + +E+ E E EK +E++ +
Sbjct: 891 SKLKALNEELHLQRINPTTVK---MKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEV 947
Query: 458 DDLQLFEKSFKNEIDTVVSQDENQSEISL----SKTLSLDKEVIS 498
+ E S + D + EIS K+L +KE +S
Sbjct: 948 TKREKLELS-QRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVS 991
Score = 70.1 bits (170), Expect = 1e-11
Identities = 130/686 (18%), Positives = 276/686 (40%), Gaps = 140/686 (20%)
Query: 48 EIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGK 107
EI EEQ+ + I QE + L+ Q + L +KQL+ L+E+
Sbjct: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQAL-----------EKQLEKMRKFLDEQAID 2075
Query: 108 YQLATEIKEKEIEGLKETLKA-------------------------------LQVSKYSL 136
+ ++ ++EI+ L++ LK L +SK L
Sbjct: 2076 REHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQL 2135
Query: 137 QKKVSEMEQKVQ-LHLLAKEDYHKQLSEIEKYYATITGQFGL-----VKENHEKLEQNVR 190
Q+ + E ++++ L +E L E K++ + + L ++ + +++ +
Sbjct: 2136 QRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEK 2195
Query: 191 EAIQSNKRLSAL-----NKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGE---ENINL 242
E ++L NK +E + ++ E++K S ++ + K+ + E + L
Sbjct: 2196 EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGL 2255
Query: 243 TIKEQ-------------KFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQ 289
IKE KF ++ + +E+ +++NE++T +Q++ + +
Sbjct: 2256 AIKESDAMSTQDQHVLFGKFAQIIQEKEVEI---DQLNEQVTKLQQQ-----LKITTDNK 2307
Query: 290 LLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKR 349
++ ++ + ++E +++ L + + ++R+ E + E++ E EK LQ E
Sbjct: 2308 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK---LQQELANIGQKTSM 2364
Query: 350 HAEELNGEINKIKNEL-------------------------SSLKETHIKLQEHYNKLCN 384
+A L+ E + +K++L + LKET+ K+ + +L +
Sbjct: 2365 NAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFS 2424
Query: 385 QKTFEED-KKFQNVPE--VNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYR 441
K E +K Q++PE VN +S +K E ++ + E+ +++ + T ++
Sbjct: 2425 LKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV--------LTEDALKSLENQTYFK 2476
Query: 442 EKEEKKEGSFI----------EEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLS 491
EE +GS I + DL+L + +I + Q + ++E+ K ++
Sbjct: 2477 SFEENGKGSIINLETRLLQLESTVSAKDLELTQ--CYKQIKDMQEQGQFETEMLQKKIVN 2534
Query: 492 LDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIH 551
L K V + + V+ + E K C +DN + + L+ E E
Sbjct: 2535 LQKIVEEKVAAALVSQIQLEAVQEYA-KFC--QDNQTISSEPERTNIQNLNQLREDE--- 2588
Query: 552 LERTRGLDVHHTDVNL-EVENNKTSFN-SILNETAHNTYHNNNKDVSENEPFKQFRLLPG 609
G D+ + + E+E+ + S++ E N E + + +LL G
Sbjct: 2589 ----LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2644
Query: 610 TREHALEKEITNSDQTKADLDSSLDI 635
+ EKE S Q L ++ ++
Sbjct: 2645 NEKKQREKEKKRSPQDVEVLKTTTEL 2670
Score = 68.9 bits (167), Expect = 2e-11
Identities = 108/498 (21%), Positives = 219/498 (43%), Gaps = 56/498 (11%)
Query: 45 REAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEE 104
+E E EE KII E ++ K+ L + L E ++ + ++ MK+ +
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSK 384
Query: 105 KGKYQLATEIKE--KEIEGL-KETLKALQVSKYSLQKKVSEMEQKV-------------Q 148
+ + Q + EIK+ +E L K K Q +Q+ E ++K+ Q
Sbjct: 385 QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
Query: 149 LHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEA 208
+ + +E + ++++E+ G+ ++ + N + N ++ LN K +
Sbjct: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ- 503
Query: 209 EICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERL-NMELELNEKIN 267
+ S K++LK+ +++ K Q ++ + L+ ++ Q ++ + E +LNE +
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE-AH 562
Query: 268 EEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVL-KENNQTLERDNELQREKV 326
+ ++ +++ K +I+ + + ++L + T + +L++L KE N L+R E Q ++
Sbjct: 563 KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
Query: 327 KENEEKFLNLQNEHEKALGTWKRHAE-ELNGEINKIKNELS-SLKETHIKLQEHYNKLCN 384
+ + L HE+ L K E E I K+K+ L K+ LQ ++
Sbjct: 623 ERLRTQLL---FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
Query: 385 QKTFEED----KKFQNVPE-----------VNNENSEMSTE----KSENTII-----QKY 420
FE+D K+ Q + E VN+++ EM+ + + E I+ +K
Sbjct: 680 TMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKG 739
Query: 421 NTEQEIREENMENFCSDTEYREKEEKKEGSFIE-----EIIIDDLQLFEKSFKNEIDTVV 475
EQE++E ++ + + +EKE + F + I+ D+ + E K I T V
Sbjct: 740 TLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK--IHTPV 797
Query: 476 SQDENQSEISLSKTLSLD 493
SQ+E + K+ S D
Sbjct: 798 SQEERLIFLDSIKSKSKD 815
Score = 66.6 bits (161), Expect = 1e-10
Identities = 108/498 (21%), Positives = 209/498 (41%), Gaps = 71/498 (14%)
Query: 32 TSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFK 91
+SL + + +++++REAE++ Q + + W+ E L ++ E+ +A F+
Sbjct: 2984 SSLKDLITKMQLQREAEVYDSSQSHESFSD-----WRGELLLALQQVFLEERSVLLAAFR 3038
Query: 92 KQLQ---------MKMCA---LEEEKGKYQLATEIKEK---------------EIEGLKE 124
+L + C ++E+ +YQ A E +K ++ G K
Sbjct: 3039 TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKI 3098
Query: 125 TLKALQVSK--------YSLQKKVSEM-EQKVQLHLLAKE--DYHKQLSEIEKYYATITG 173
TLK Q S+ Y++Q+K S+M E +V+L + + +QLS + A +
Sbjct: 3099 TLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKS 3158
Query: 174 QFGLVKENHEKLEQNVREAIQSNKRLSALN---KKQEAEICSLKKELKKAASDLIKSKVT 230
+ K +LE ++ + K L A K + E+ L L AS+ KS+
Sbjct: 3159 ELAQTKL---ELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL---ASEQKKSR-E 3211
Query: 231 CQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQH---- 286
Q+ + +E L E++ +E E L LE ++ N ++ + E+++ ++ Q
Sbjct: 3212 LQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES 3271
Query: 287 MQQLLRQQIQANTEMEAELKVLKENNQTLERD--NELQREKVKENEEKFLNLQNEHEKAL 344
+ L Q+ EL+VL E+ + R+ + L RE+ E LQ+
Sbjct: 3272 QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRER-----ELHAQLQSSDGTGQ 3326
Query: 345 GTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNEN 404
+E+L E+ K L+E H ++ E N+ K + Q +
Sbjct: 3327 SRPPLPSEDLLKELQK------QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3380
Query: 405 SEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIID-DLQLF 463
+ TE+ NT QK E + + E+++ + + + EG ++ I+ + Q
Sbjct: 3381 KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQEL 3440
Query: 464 EKSFKNEIDTVVSQDENQ 481
E+ K E ++ Q+ N+
Sbjct: 3441 EREEKRESRRILYQNLNE 3458
Score = 62.8 bits (151), Expect = 2e-09
Identities = 131/681 (19%), Positives = 287/681 (42%), Gaps = 103/681 (15%)
Query: 109 QLATEIKEKEIEGLKETLKALQVSKYSLQKK---VSEMEQKVQLHLLAKEDYHKQLSEIE 165
+L E++E + E L+ LQ + +++++ ++++ +Q K++ ++ E+
Sbjct: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELT 232
Query: 166 KYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKA---AS 222
+ + QF ++ + + +R + S+ L KQ+ I + +++L++
Sbjct: 233 EQSQKLQIQFQQLQAS-----ETLRNSTHSSTAADLLQAKQQ--ILTHQQQLEEQDHLLE 285
Query: 223 DLIKSK--VTCQYKMGEENINLTIKEQ-------KFQELQERLNMELELNEKINEEITHI 273
D K K T Q +E I + EQ +E+QE+ + ELN KI EE
Sbjct: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345
Query: 274 QEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDN------------EL 321
E K + + + + +L Q +Q N E++ +K+ N++ ER + EL
Sbjct: 346 LELKDKLTTADKLLGELQEQIVQKNQEIK-NMKLELTNSKQKERQSSEEIKQLMGTVEEL 404
Query: 322 QREKVKENE---EKFLNLQNEHEKALGTWKRHAEELNG-EINKIKNELSSLKETHIKLQE 377
Q+ K+++ + ++ E ++ L + +E+ G +I ++K EL +++
Sbjct: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL---------IRQ 455
Query: 378 HYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSD 437
H ++ KT + + + +N K N I + N ++++ N +
Sbjct: 456 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI--KLQDTNSQ----- 508
Query: 438 TEYREKEEKKEGSFIE---------EIIIDDLQLFEKSFKNEIDTVVSQDE--NQSEISL 486
+EK +++ G +E E ++++L + + T+ Q+ N++ SL
Sbjct: 509 ---KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565
Query: 487 SKTLSLDKEVISQGQTSNVTD-NRKSVTTEIKDKI-CLEKDNGCTEFKSPNNHFVVLDTA 544
S L E++S ++ + ++ T K K+ LEK+ VLD
Sbjct: 566 STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN-----------AVLDRM 614
Query: 545 IETEKIHLE--RTRGLDVHHTDVNLEVENNKTSFNSILNETAHN--TYHNNNKDVSENEP 600
E+++ LE RT+ L H +++ E+ + + + N ++ D +NE
Sbjct: 615 AESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEM 674
Query: 601 FKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQC 660
++ T + + IT +Q ++ D++++ V + + N +
Sbjct: 675 SQKIE----TMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ----- 725
Query: 661 KIKQIQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSK 720
K+I++L ++ + L ++ + LQ+ + LEK D+ +A A +
Sbjct: 726 --KEIEILRQEEKEKGTLEQEVQE-LQLKTELLEKQMKEKENDL----QEKFAQLEAENS 778
Query: 721 LLLKNSDKNVHSMSMLVKPNS 741
+LK+ K + M + P S
Sbjct: 779 -ILKDEKKTLEDMLKIHTPVS 798
Score = 62.0 bits (149), Expect = 3e-09
Identities = 110/517 (21%), Positives = 217/517 (41%), Gaps = 70/517 (13%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKE---TLAEQ 82
Q+ + + + +E ++ ++ I + Q+ I+E +LK +++L N K TL
Sbjct: 666 QIDGLQNEMSQKIETMQFEKDNLITKQNQL---ILEISKLKDLQQSLVNSKSEEMTLQIN 722
Query: 83 HKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIE----GLKETLKALQVSKYSLQK 138
+ +Q + + LE+E + QL TE+ EK+++ L+E L+ L+
Sbjct: 723 ELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD 782
Query: 139 KVSEMEQKVQLHL-LAKEDYHKQLSEIEKYYATITGQFG---LVKENHEKLEQNVR---E 191
+ +E +++H +++E+ L I+ + L++EN + +Q ++ E
Sbjct: 783 EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEE 842
Query: 192 AIQSNKRLSALNKKQEAEICSLKKE---LKKAASDL--IKSKVTCQYK-----MGEE--- 238
+ S K E L++E L K DL K+K +YK + EE
Sbjct: 843 IEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHL 902
Query: 239 -NINLT---IKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQ 294
IN T +K F E + + LE+ E + ++ T + E+ + + Q L
Sbjct: 903 QRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962
Query: 295 IQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGT-------- 346
+ + E+ L E ++L+++ E + +E E + + E+ ++ T
Sbjct: 963 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1022
Query: 347 ----WKRHAEELNGEINKIKNELSSLK-ETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVN 401
R AE ++NK E S + E + + N +++ +E ++P V
Sbjct: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE---NMTVGEESKQEQLILDHLPSVT 1079
Query: 402 NENSEMSTEKSENTIIQK----YNTEQEIREENME--NFCSD----------TEYREKEE 445
E+S +T+ SEN +QK +EQ ME C EY E E+
Sbjct: 1080 KESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK 1139
Query: 446 KKEGSFIEEIII----DDLQLFEKSFKNEIDTVVSQD 478
K ++E +I + ++ +K + E+ T+ +Q+
Sbjct: 1140 DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176
Score = 61.2 bits (147), Expect = 5e-09
Identities = 119/628 (18%), Positives = 255/628 (40%), Gaps = 107/628 (17%)
Query: 15 LQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQN 74
+++ E +QL + ++ +E+ E + E++ E Q+L Q E +
Sbjct: 2171 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK 2230
Query: 75 QKETLAEQHKEAMAVFKKQLQMKMCALEEEK-----------GKYQLATEIKEKEIEGLK 123
+ T ++ ++ +FK ++ A++E GK+ + KE EI+ L
Sbjct: 2231 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2290
Query: 124 ETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHE 183
E QV+K Q K++ + + E+ ++ + ++E + VK N E
Sbjct: 2291 E-----QVTKLQQQLKITTDNKVI-------EEKNELIRDLETQIECLMSDQECVKRNRE 2338
Query: 184 KLEQNVREAIQS-NKRLSALNKKQEAEICSLKKE---LKKAASDLIKSKVTCQYKMGEEN 239
+ + + E I+ + L+ + +K SL +E LK +I K+ + ++ N
Sbjct: 2339 EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2398
Query: 240 INLTIKEQKFQELQERLNM----------ELELNEKI--------NEEITHIQEEKQ--D 279
+T + +E ++N E E EKI N I H+ ++K +
Sbjct: 2399 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2458
Query: 280 IIISFQHMQQLLRQQIQANTE-------MEAELKVLKENNQTLERDNELQR--EKVKENE 330
++++ ++ L Q + E + E ++L+ + +D EL + +++K+ +
Sbjct: 2459 VVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518
Query: 331 EKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLC--NQKTF 388
E+ +K + ++ EE K + + + ++ + Y K C NQ
Sbjct: 2519 EQGQFETEMLQKKIVNLQKIVEE--------KVAAALVSQIQLEAVQEYAKFCQDNQTIS 2570
Query: 389 EEDKK--FQN-------------------VPEVNNENSEMST----EKSENTIIQKYNTE 423
E ++ QN + E+ ++ EM T EK + I +K E
Sbjct: 2571 SEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLE 2630
Query: 424 QEIREENMENFCSDTEYREKE-EKKEGSFIEEIIIDDLQLF----EKSFKNEIDTVVSQD 478
+E + ++ E +++E EKK E++ +LF E F NE++ + ++
Sbjct: 2631 KEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES 2690
Query: 479 -ENQSEIS--LSKTLSLDKEVISQGQTSNVTDNRKSVT------TEIKDKICLEKDNGCT 529
++E++ K L +E++ + +N+T +K ++ E K+K+ + + T
Sbjct: 2691 VATKAELASYKEKAEKLQEELLV--KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2748
Query: 530 EFKSPNNHFVVLDTAIETEKIHLERTRG 557
E + + I+ K +T G
Sbjct: 2749 EVQESKKACMFEPLPIKLSKSIASQTDG 2776
Score = 56.6 bits (135), Expect = 1e-07
Identities = 96/460 (20%), Positives = 200/460 (43%), Gaps = 65/460 (14%)
Query: 16 QSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQ-KETLQN 74
+ S+ L + ++ +LE EL ++ +EQ+ + ELK + +T
Sbjct: 3107 EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3166
Query: 75 QKETLAEQHK-----------------------EAMAVFKKQLQMKMCALEEEKGKYQLA 111
+ TL QHK + +A +K+ + ALE+EK K +
Sbjct: 3167 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS 3226
Query: 112 TEIKEKEIEGLKETLKA-----LQVSKYSLQKK--VSEMEQKVQLHLLAKEDYHKQLSEI 164
E ++E+E LK +L++ LQ++ Q+K ++E +QK++ + Y QLSE
Sbjct: 3227 EERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML---YDAQLSEE 3283
Query: 165 E----KYYATITGQFGLVKENHEKL--EQNVREAIQSNKRLSALNKKQEAE--ICSLKKE 216
+ + + + ++E L E+ + +QS+ +E + L+K+
Sbjct: 3284 QGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQ 3343
Query: 217 LKKAASDLIK-SKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQE 275
L++ S +++ T +YK+ +++ + Q ++ L E E N + +++ +Q
Sbjct: 3344 LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTEGQKKMHELQS 3402
Query: 276 EKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLN 335
+ +D +Q+ L ++ Q +++ E + L+ Q ++ EL+RE+ +E+ +
Sbjct: 3403 KVED-------LQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK-QELEREEKRESRR--IL 3452
Query: 336 LQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQE---------HYNKLCNQK 386
QN +E TW ++ + + K E + + + KL E H ++ QK
Sbjct: 3453 YQNLNEPT--TWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQK 3510
Query: 387 TFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEI 426
K Q +P+ +E + T E+ I + N ++ I
Sbjct: 3511 LQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEII 3550
Score = 41.2 bits (95), Expect = 0.005
Identities = 132/733 (18%), Positives = 277/733 (37%), Gaps = 100/733 (13%)
Query: 12 TFTLQSSSETLFSIQLLDFKTSLL---EALEELRMRREAEIHYEEQIGKIIVETQELKWQ 68
TF ++ S S+ +D L+ E LE++R + +Q +++ + + +
Sbjct: 1558 TFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQME 1617
Query: 69 K-----ETLQNQKETLAEQHKEAMAVFKKQL--QMKMCALEEEKGKYQLATEIKEKEIEG 121
+ E LQ + + L Q + ++ + L + + LEE + QL+ +EK
Sbjct: 1618 RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677
Query: 122 LKETLKALQVSKYSL---------QKKVSEMEQKVQLHLLAKEDY--HKQLSEIEKYYAT 170
L+ + Q + +K++ + V +L+ E Y K + + K
Sbjct: 1678 LRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLE 1737
Query: 171 ITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKK----------- 219
+ V+E + + + ++ ++L + EAE S+K + +
Sbjct: 1738 VVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAE-ASVKSCVHEEHTRVTDESIP 1796
Query: 220 --AASDLIKSKVTCQYKMGEENINLTIK-----------EQKFQELQERLNMELELNEKI 266
+ SD+ ++ + K+ EE L+ + + + +EL LN+ L +
Sbjct: 1797 SYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELM--LNISSRLQAAV 1854
Query: 267 NEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKV 326
+ + I E + + +L+R+ + E LK +E + L ++ RE++
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR-AREQL 1913
Query: 327 KENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIK-------NELSSLKETHIKLQEHY 379
K + + + ++R +E I++++ N L L+ ++QE
Sbjct: 1914 AVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEER 1973
Query: 380 NKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSE--------NTIIQKYNTEQEIREENM 431
L QK + + ++ E ++ EK E +QK EI E
Sbjct: 1974 ELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQ 2033
Query: 432 ENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNE-IDTVVSQDENQSEI-SLSKT 489
+ + E + E + + + L+ K + ID +D Q EI L +
Sbjct: 2034 VSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093
Query: 490 LSLDK--EVISQGQTSNVTD--NRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAI 545
L + + IS+ QT V N T+ ++ L K+ + + N L+ +
Sbjct: 2094 LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2153
Query: 546 -ETEKIHLERTR---GLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSE-NEP 600
E E+ L R G +++LEV+ + + K+++ E
Sbjct: 2154 RELEQALLVEDRKHFGAVEAKPELSLEVQ----------LQAERDAIDRKEKEITNLEEQ 2203
Query: 601 FKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQC 660
+QFR +E+ N ++ L L+I+K + L + + DD
Sbjct: 2204 LEQFR-----------EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDD--- 2249
Query: 661 KIKQIQLLTKKSE 673
++++ L K+S+
Sbjct: 2250 -MEKLGLAIKESD 2261
Score = 32.3 bits (72), Expect = 2.5
Identities = 74/445 (16%), Positives = 174/445 (39%), Gaps = 43/445 (9%)
Query: 39 EELRMRREAEIHYEEQ-IGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
EE ++ E ++ +E +G+ + Q + ++ + A Q E +LQ +
Sbjct: 1044 EESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSE-----NDKLQKE 1098
Query: 98 MCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDY 157
+ L+ E+ +L E ++ L + QV +Y +K + + + A+E+
Sbjct: 1099 LNVLKSEQNDLRLQMEA-QRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157
Query: 158 HKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKEL 217
K+L +I + ++ K ++ E + + L K E + L
Sbjct: 1158 IKELQKIHQ-----------LELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
Query: 218 KKAASDLIKSKVTCQYKMGE-ENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEE 276
+ + C+ + EN I E + ELQ+ + E ++ + + EE
Sbjct: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEE 1266
Query: 277 KQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQR-EKVKENEEKFLN 335
+++ + ++ QQ E + KE + L +++ E + N + L+
Sbjct: 1267 YNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLS 1326
Query: 336 LQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK--LCNQKTFEEDKK 393
+ EK +L ++ ++++ +SSL++ + +++Y C QK + +
Sbjct: 1327 SLQDLEKT---------KLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377
Query: 394 FQNVPEVNNENSEMSTEKSENTIIQ------------KYNTEQEIREENMENFCSDTEYR 441
P + ++ ++ ++ T+ +++ E ++EE + +Y+
Sbjct: 1378 STVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQ 1437
Query: 442 EKEEKKEGSFIEEIIIDDLQLFEKS 466
E+ E++ I + I Q E S
Sbjct: 1438 EQLEEEVAKVIVSMSIAFAQQTELS 1462
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 82.8 bits (203), Expect = 2e-15
Identities = 98/399 (24%), Positives = 183/399 (45%), Gaps = 49/399 (12%)
Query: 39 EELRMRREAEIH-----YEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQ 93
EE R+E +I +EQ KI + ++++ Q+E ++ Q+E + E+ ++ ++Q
Sbjct: 360 EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK----MRRQ 415
Query: 94 LQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLA 153
+M M EE+ + + KE++I L+E K Q+K+ E E+K Q
Sbjct: 416 EEM-MWEKEEKMRRQEEMMWEKEEKIRELEE--------KMHEQEKIREQEEKRQEEEKI 466
Query: 154 KEDYHKQLSEIEKYYAT--ITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEIC 211
+E +Q E + + I Q ++E EK+ + E I +++ K+QE E
Sbjct: 467 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ-EEKIHEQEKIREEEKRQEQEEM 525
Query: 212 SLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEIT 271
++E + ++ + K K+ E+ + +E+K +E+++ + EKI E
Sbjct: 526 WRQEEKIREQEEIWRQKE----KIHEQEEKIRKQEEKMWRQEEKMH---DQEEKIRE--- 575
Query: 272 HIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEE 331
QEEK ++ +R+Q + E E +++ +E Q E Q EK+ E EE
Sbjct: 576 --QEEK------VWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627
Query: 332 KFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQ--KTFE 389
K +Q + EK +R E++ + KI+ + ++E +QE K+ Q K E
Sbjct: 628 K---MQEQEEK----MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 680
Query: 390 EDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIRE 428
+++K Q E E E+ E + Q+ QE +E
Sbjct: 681 QEEKMQEQEEKMRRQEEKMWEQ-EVRLRQQEEKMQEHQE 718
Score = 75.1 bits (183), Expect = 3e-13
Identities = 73/327 (22%), Positives = 160/327 (48%), Gaps = 31/327 (9%)
Query: 39 EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKM 98
+E +MRR+ E+ +E++ + I E +E ++E ++ Q+E E+ K +++ + KM
Sbjct: 422 KEEKMRRQEEMMWEKE--EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 479
Query: 99 CALEE----EKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLH---L 151
EE ++ K + E ++ E + E K + K Q+++ E+K++
Sbjct: 480 WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW 539
Query: 152 LAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEIC 211
KE H+Q +I K + Q + + EK+ + + + +++ ++QE +I
Sbjct: 540 RQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKI----REQEEKIR 595
Query: 212 SLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEIT 271
++++++ ++ + + + KMGE+ + +E+K QE +E++ + EKI E+
Sbjct: 596 EQEEKIREQ-EEMTQEQ---EEKMGEQEEKMCEQEEKMQEQEEKMRRQ---EEKIREQEK 648
Query: 272 HIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEE 331
I+E+++ I + ++++++Q + E E ++ +E Q E Q EK+ E E
Sbjct: 649 KIREQEEKI----REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE- 703
Query: 332 KFLNLQNEHEKALGTWKRHAEELNGEI 358
+ L+ + EK + H E L I
Sbjct: 704 --VRLRQQEEK----MQEHQEHLEAAI 724
Score = 71.2 bits (173), Expect = 5e-12
Identities = 89/409 (21%), Positives = 184/409 (44%), Gaps = 71/409 (17%)
Query: 38 LEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMK 97
+EEL R+A ++ + + +ELK + LQ +K L E K + + K+L+ K
Sbjct: 256 IEELTKERDA---LSLELYRNTITDEELKEKNAKLQ-EKLQLVESEKSEIQLNVKELKRK 311
Query: 98 MCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDY 157
+ E+ K L + + E + L + L+++ LQ +V E E +L+ +E
Sbjct: 312 L-----ERAKLLLPQQQLQAEADHLGKELQSVSAK---LQAQVEENELWNRLNQQQEEKM 363
Query: 158 HKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKEL 217
+Q +I+++ I Q ++E EK+ + + +++ E+ K+E
Sbjct: 364 WRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM------------RRQEEMMWEKEEK 411
Query: 218 KKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEK 277
+ +++ K + KM + + KE+K +EL+E+++ + EKI E+ QEE+
Sbjct: 412 MRRQEEMMWEK---EEKMRRQEEMMWEKEEKIRELEEKMHEQ----EKIREQEEKRQEEE 464
Query: 278 QDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQ 337
+ +R+Q E E K+ ++ + E Q EK++E EEK
Sbjct: 465 K------------IREQ---EKRQEQEAKMWRQEEKIRE-----QEEKIREQEEKM---- 500
Query: 338 NEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNV 397
W++ EE E KI+ E ++ + QE + + +++K +
Sbjct: 501 ---------WRQ--EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQE 549
Query: 398 PEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEK 446
++ + +M ++ + ++ E++IRE+ + + + + RE+EEK
Sbjct: 550 EKIRKQEEKMWRQEEK-----MHDQEEKIREQEEKVWRQEEKIREQEEK 593
Score = 70.9 bits (172), Expect = 6e-12
Identities = 85/386 (22%), Positives = 174/386 (45%), Gaps = 35/386 (9%)
Query: 76 KETLAEQHKEAMAVFKKQLQMKMCALEE---EKGKYQLATEIKEKEIEGLKETLKALQVS 132
++ + QH+EA+ +++L+ ++ + +K + Q+A + ++ L+ + L
Sbjct: 171 EQKASHQHQEAL---RRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 227
Query: 133 KYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEK---------YYATITGQFGLVKENHE 183
+ K E+EQ + K+ + + E+ K Y TIT + +KE +
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE--LKEKNA 285
Query: 184 KLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYK-MGEENINL 242
KL++ + + ++S K LN K+ LK++L++A L + ++ + +G+E ++
Sbjct: 286 KLQEKL-QLVESEKSEIQLNVKE------LKRKLERAKLLLPQQQLQAEADHLGKELQSV 338
Query: 243 TIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEME 302
+ K Q E E N LN++ E++ +E+ Q+ Q ++ +R+Q + E E
Sbjct: 339 SAKLQAQVEENELWN---RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 395
Query: 303 AELKVLKENNQTLERDNELQREKVKENEEKFLNLQN---EHEKALGTWKRHAEELNGEIN 359
+++ +E E Q E + E EEK + E E+ + R EE E
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI----RELEEKMHEQE 451
Query: 360 KIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQK 419
KI+ + +E ++ + K + +++K + E E E + E Q+
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE 511
Query: 420 YNTEQEIREENMENFCSDTEYREKEE 445
E+E R+E E + + + RE+EE
Sbjct: 512 KIREEEKRQEQEEMWRQEEKIREQEE 537
Score = 67.4 bits (163), Expect = 7e-11
Identities = 74/352 (21%), Positives = 167/352 (47%), Gaps = 33/352 (9%)
Query: 39 EELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKM 98
+E +MRR+ E+ +E++ + + +E+ W+KE ++E + + +E + ++L+ KM
Sbjct: 394 QEEKMRRQEEMMWEKE--EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI----RELEEKM 447
Query: 99 CALEEEKGKYQLATEIKEKEIEGLKETLKALQ--VSKYSLQKKVSEMEQKVQLHLLAKED 156
E+EK + Q E K +E E ++E K + + ++K+ E E+K+ +E
Sbjct: 448 H--EQEKIREQ---EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI------REQ 496
Query: 157 YHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKE 216
K + EK + + ++E ++ EQ + R +Q+ +I +++
Sbjct: 497 EEKMWRQEEKIH-----EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551
Query: 217 LKKAASDLIKSKVTC---QYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHI 273
++K + + + + K+ E+ + +E+K +E +E++ E EKI E+
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIR---EQEEKIREQEEMT 608
Query: 274 QEEKQDIIISFQHM-QQLLRQQIQANTEMEAELKVLKENNQTLERDNEL--QREKVKENE 330
QE+++ + + M +Q + Q Q E K+ ++ + E++ ++ Q E ++E E
Sbjct: 609 QEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 668
Query: 331 EKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKL 382
EK + + + + E++ + K+ + L++ K+QEH L
Sbjct: 669 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 82.8 bits (203), Expect = 2e-15
Identities = 108/522 (20%), Positives = 221/522 (42%), Gaps = 60/522 (11%)
Query: 30 FKTSLLEALEELRMRREAEIHYEEQIGKIIVETQEL--------KWQKETLQNQKETLAE 81
FK LL LEE+R +E++ ++I TQ + ++QK + + +
Sbjct: 769 FKAGLLGLLEEMR---------DEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQ 819
Query: 82 QHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVS 141
+ A K MK+ K K L + EKE+ +KE + + + K
Sbjct: 820 YNVRAFMNVKHWPWMKLYF----KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRK 875
Query: 142 EMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQS------ 195
E+E+K+ + K D Q+ A + + + +LE ++E +
Sbjct: 876 ELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE 935
Query: 196 -NKRLSALNKKQEAEICSLKKEL-------------KKAASDLIKSKVTCQYKMGEENIN 241
N L+A +K E E LKK++ K A + +K+ + E
Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995
Query: 242 LTIKEQKFQELQERLNMELELNE-KIN---EEITHIQEEKQDIIISFQHMQQLLRQQIQA 297
LT +++ QE ++ +L+ E K+N + ++++ D+ S + +++ +A
Sbjct: 996 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERA 1055
Query: 298 NTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQN--EHEKALG-TWKRHAEEL 354
++E +LK+ +E+ +E D + EK+K+ E + LQ+ E E+ALG ++ +EL
Sbjct: 1056 KRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKEL 1115
Query: 355 NGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSEN 414
I +++ E+ + + + K ++ + L +++ E ++ + + EM+ K
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDL-SRELEEISERLEEAGGATSAQIEMN--KKRE 1172
Query: 415 TIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEI-----IIDDLQLFEKSFKN 469
QK +++ E +++ + R+K E+I + L+ + K
Sbjct: 1173 AEFQK--MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 470 EIDTVVSQDENQSEI--SLSKTLSLDKEVISQGQTSNVTDNR 509
EID + S E S+ +L K ++ +S+ +T R
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQR 1272
Score = 77.0 bits (188), Expect = 9e-14
Identities = 137/677 (20%), Positives = 270/677 (39%), Gaps = 91/677 (13%)
Query: 26 QLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKE 85
++ + + + E EE+ R + E+Q + E +E+ + E E +K+
Sbjct: 1111 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1170
Query: 86 AMAVFKK-QLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEME 144
A F+K + ++ L+ E L + + E L E + LQ K L+K+ SEM+
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQKLEKEKSEMK 1229
Query: 145 QKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNK 204
++ E K +EK + Q +K E+ ++ + + L+A
Sbjct: 1230 MEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND-------LTAQRA 1282
Query: 205 KQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNE 264
+ + E ++L + K + Q G +Q F + E L +LE
Sbjct: 1283 RLQTESGEYSRQLDE------KDTLVSQLSRG---------KQAFTQQIEELKRQLEEEI 1327
Query: 265 KINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELK--VLKENNQTLERDNELQ 322
K + H + S +H LLR+Q + E +AEL+ + K N++ + + +
Sbjct: 1328 KAKSALAHALQ-------SSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYE 1380
Query: 323 REKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKL 382
+ ++ EE E +K L + AEE + + + +SL++T +LQ L
Sbjct: 1381 TDAIQRTEE-----LEEAKKKLAQRLQDAEE---HVEAVNAKCASLEKTKQRLQNEVEDL 1432
Query: 383 ------CNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCS 436
N DKK +N ++ E +K E T + +++E R + E F
Sbjct: 1433 MIDVERTNAACAALDKKQRNFDKILAE----WKQKCEETHAELEASQKESRSLSTELFKI 1488
Query: 437 DTEYREKEE-----KKEGSFIEEIIIDDLQLFEKSFK-----NEIDTVVSQDENQSEISL 486
Y E + K+E +++ I D + + K +I V Q++++ + +L
Sbjct: 1489 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAAL 1548
Query: 487 SKT-LSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAI 545
+ SL+ E +G+ + V +E+ KI EKD + K NH ++++
Sbjct: 1549 EEAEASLEHE---EGKILRIQLELNQVKSEVDRKIA-EKDEEIDQMK--RNHIRIVESMQ 1602
Query: 546 ET---------EKIHLERTRGLDVHHTDVNL--------EVENNKTSFNSILNETAHNTY 588
T + I L++ D++ ++ L E N + +IL +T +
Sbjct: 1603 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHL- 1661
Query: 589 HNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPV--PCQKYS 646
+ + E K+ + R + L+ EI T + S I + + ++
Sbjct: 1662 ---DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718
Query: 647 LRNSSNVMLDDKQCKIK 663
L ++ N L + + K++
Sbjct: 1719 LLHTQNTSLINTKKKLE 1735
Score = 71.2 bits (173), Expect = 5e-12
Identities = 113/582 (19%), Positives = 241/582 (41%), Gaps = 55/582 (9%)
Query: 33 SLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKK 92
SL +A E + +I E +I ++ ++ + L +K L ++ E
Sbjct: 901 SLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID- 959
Query: 93 QLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLL 152
L++ + +E+EK + + +E+ GL ET+ L K +LQ E Q+ L
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ----EAHQQTLDDLQ 1015
Query: 153 AKEDYHKQLSE----IEKYYATITGQFGLVKENHEKLEQNVREA-----IQSNKRLSALN 203
A+ED L++ +E+ + G K+ LE+ R+ + + N
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEN 1075
Query: 204 KKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKE--QKFQELQERLNMELE 261
KQ+ + KKE + + ++SK+ + +G + + IKE + +EL+E + E
Sbjct: 1076 DKQQLDEKLKKKEFEMSG---LQSKIEDEQALGMQ-LQKKIKELQARIEELEEEIEAERA 1131
Query: 262 LNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNEL 321
K ++ + + E ++I + QI+ N + EAE + ++ + + +E
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 322 QREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNK 381
+++ + E L K+ E+ E+ ++L+S ET K + + K
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 382 LCNQ--------KTFEEDKKFQNVPEVNNENSEMSTEKSE--------NTIIQKYNTEQE 425
+C KT EE+++ + + ++ + + + TE E +T++ + + ++
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQ-RLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310
Query: 426 IREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQ--DENQSE 483
+ +E E EE K S + + +S +++ D + Q +E +++
Sbjct: 1311 AFTQQIEELKRQLE----EEIKAKSALAHAL--------QSSRHDCDLLREQYEEEQEAK 1358
Query: 484 ISLSKTLSLDKEVISQGQTSNVTD--NRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVL 541
L + +S ++Q +T TD R E K K+ + ++ N L
Sbjct: 1359 AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL 1418
Query: 542 DTAIETEKIHLERTRGLDVHHTDVN-LEVENNKTSFNSILNE 582
+ + + +E +DV T+ ++ + +F+ IL E
Sbjct: 1419 EKTKQRLQNEVEDLM-IDVERTNAACAALDKKQRNFDKILAE 1459
Score = 67.4 bits (163), Expect = 7e-11
Identities = 86/478 (17%), Positives = 217/478 (45%), Gaps = 39/478 (8%)
Query: 16 QSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQI----------GKIIVETQEL 65
Q S +L S +L K + E+L++L + + +++I GK I E +++
Sbjct: 1475 QKESRSL-STELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1533
Query: 66 KWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKET 125
K Q E +++ + E+ + ++ + ++ L + K + K++EI+ +K
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN 1593
Query: 126 -LKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHK---QLSEIEKYYATITGQFGLVKEN 181
++ ++ + +L ++ ++L + D ++ QL+ + A + +
Sbjct: 1594 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAI 1653
Query: 182 HEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENIN 241
+ + ++ +A++S + L E L+ E+++ + L +++ + K+ E+
Sbjct: 1654 LKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS--RKIAEQE-- 1709
Query: 242 LTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEM 301
L ++ Q L + + +K+ +I+ IQ E +DII ++ ++ ++ I M
Sbjct: 1710 LLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMM 1769
Query: 302 EAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKI 361
ELK ++ + LER + + VK+ + + L + AL K+ ++L + ++
Sbjct: 1770 AEELKKEQDTSAHLERMKKNLEQTVKDLQHR---LDEAEQLALKGGKKQIQKLEARVREL 1826
Query: 362 KNELSSLKETHIK----LQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTII 417
+ E+ S ++ +++ L++H K+ + T++ ++ +N+ + + ++ + +
Sbjct: 1827 EGEVESEQKRNVEAVKGLRKHERKV-KELTYQTEEDRKNILRLQDLVDKLQAK------V 1879
Query: 418 QKYNTEQEIREE----NMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEI 471
+ Y + E EE N+ F E EE +E + I E ++ L++ + +I
Sbjct: 1880 KSYKRQAEEAEEQSNVNLSKF--RRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 35.4 bits (80), Expect = 0.29
Identities = 51/246 (20%), Positives = 102/246 (41%), Gaps = 28/246 (11%)
Query: 298 NTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHE------KALGTWKRHA 351
+ E E E+ +KE + + + K KE EEK + L E +A A
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 352 EELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNN--ENSEMST 409
EE ++ K K +L + + + E ++ + T ++ K E+ ++ E++
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 410 EKSENTIIQKYNTEQEIRE--ENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSF 467
K E +K+ TE +++ E M +T + +EKK + +DDLQ E
Sbjct: 966 AKVEK---EKHATENKVKNLTEEMAGL-DETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 468 ----KNEIDTVVSQDENQSEISLSKTLSLDKE----------VISQGQTSNVTDNRKSVT 513
K +I D+ + + K + +D E ++Q T ++ ++++ +
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081
Query: 514 TEIKDK 519
++K K
Sbjct: 1082 EKLKKK 1087
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,970,465
Number of Sequences: 37866
Number of extensions: 1774950
Number of successful extensions: 16837
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 265
Number of HSP's successfully gapped in prelim test: 1115
Number of HSP's that attempted gapping in prelim test: 7909
Number of HSP's gapped (non-prelim): 4667
length of query: 1079
length of database: 18,247,518
effective HSP length: 113
effective length of query: 966
effective length of database: 13,968,660
effective search space: 13493725560
effective search space used: 13493725560
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.