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Search of human proteins with 83415184
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83415184 transmembrane and tetratricopeptide repeat
containing 1 [Homo sapiens]
(774 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83415184 transmembrane and tetratricopeptide repeat containin... 1557 0.0
gi|118766328 transmembrane and tetratricopeptide repeat containi... 307 3e-83
gi|118766330 transmembrane and tetratricopeptide repeat containi... 307 3e-83
gi|224809432 transmembrane and tetratricopeptide repeat containi... 215 1e-55
gi|22749211 transmembrane and tetratricopeptide repeat containin... 162 1e-39
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 139 1e-32
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 139 1e-32
gi|34304360 nephrocystin 3 [Homo sapiens] 67 5e-11
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 65 2e-10
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 65 2e-10
gi|118402596 cell division cycle protein 23 [Homo sapiens] 65 3e-10
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom... 63 1e-09
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 63 1e-09
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 63 1e-09
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 62 2e-09
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 62 2e-09
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 62 2e-09
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap... 61 3e-09
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap... 61 3e-09
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap... 61 3e-09
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap... 61 3e-09
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi... 61 3e-09
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 61 3e-09
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 60 8e-09
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 60 8e-09
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 60 8e-09
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 59 1e-08
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 58 4e-08
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 57 5e-08
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 55 2e-07
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 1557 bits (4032), Expect = 0.0
Identities = 774/774 (100%), Positives = 774/774 (100%)
Query: 1 MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60
MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA
Sbjct: 1 MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60
Query: 61 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120
DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV
Sbjct: 61 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120
Query: 121 CLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGC 180
CLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGC
Sbjct: 121 CLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGC 180
Query: 181 HSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET 240
HSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
Sbjct: 181 HSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET 240
Query: 241 IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVV 300
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVV
Sbjct: 241 IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVV 300
Query: 301 AERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSR 360
AERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSR
Sbjct: 301 AERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSR 360
Query: 361 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR 420
ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
Sbjct: 361 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR 420
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL
Sbjct: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS
Sbjct: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
Query: 541 HHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE 600
HHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
Sbjct: 541 HHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE 600
Query: 601 AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHD 660
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHD
Sbjct: 601 AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHD 660
Query: 661 KALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMN 720
KALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMN
Sbjct: 661 KALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMN 720
Query: 721 MGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT 774
MGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT
Sbjct: 721 MGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT 774
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 307 bits (786), Expect = 3e-83
Identities = 222/635 (34%), Positives = 325/635 (51%), Gaps = 48/635 (7%)
Query: 2 NPFYFHAVNIILHCLVTLVLMYTCDKTVF-------KNRGL------AFVTALLFAVHPI 48
+P FH VNI+LH ++ VLM +F K R L + + ALLFAVHP+
Sbjct: 103 HPVGFHVVNILLHSGIS-VLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPV 161
Query: 49 HTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAM 108
HTE VAG+VGRAD+L L FLL+FL Y ++ + G+ ST F++LLS+FLG AM
Sbjct: 162 HTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSST---FWVLLSIFLGAVAM 218
Query: 109 LVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGK- 167
L KE GITV G+ V+D+ + G Q + SL NG
Sbjct: 219 LCKEQGITVLGLNAVFDILVI---------GKFNVLEIVQKVLHKDKSLENLGMLRNGGL 269
Query: 168 --QQRFPHKGAWGGCH------SPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWL 219
+ G G + PP P S A ++R + Y+Y + N WL
Sbjct: 270 LFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPAS-FADSMLVRAVNYNYYYSLNAWL 328
Query: 220 LLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKE--VLV 277
LL P LC+DW +G IPL+++I D R +A A+ L+ L C A HK + +
Sbjct: 329 LLCPWWLCFDWSMGCIPLIKSISDWRVIA--LAALWFCLIGLICQALCSEDGHKRRILTL 386
Query: 278 GLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIV 337
GL FLV PF+PASNLFFRVGFVVAERVLY+PS+GYC+L G L + LI
Sbjct: 387 GLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKK---KKLIA 443
Query: 338 STVL-LLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIY 396
+ VL +L + + + V ++ W S E LFRS + P NAKVHYN L D+G AI
Sbjct: 444 AVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIR 503
Query: 397 HYRTALKLYPRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQ 453
+YR A++L P++ A+NNLG + + + EA+ A+Q+ P A NLG + S
Sbjct: 504 YYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSL 563
Query: 454 EKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNN 513
++ E A + +IK+ ++ D Y +L L A+ R +A ++ P+ S NN
Sbjct: 564 KRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNN 623
Query: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV-A 572
+ L +TG +A A ++A++L P+ H M +L + + +E + +A++
Sbjct: 624 MIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 683
Query: 573 HKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607
+ A L LY+ G + A + Y+ + L P+
Sbjct: 684 NAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPT 718
Score = 82.8 bits (203), Expect = 1e-15
Identities = 80/325 (24%), Positives = 146/325 (44%), Gaps = 14/325 (4%)
Query: 444 FNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKN 503
F G L K +KK+ L ++ G F + +L +L E ++ E+++++ +
Sbjct: 427 FGFGALSKHTKKKK-----LIAAVVLGILFIN---TLRCVLRSGE-WRSEEQLFRSALSV 477
Query: 504 CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEE 563
CP ++ +H N G L D G A+ +Y++A++L+P + AM NLG + + E AEE
Sbjct: 478 CPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEE 537
Query: 564 WYKRALQVAHK-AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVM 622
A+Q+ A LG + + R+E A Q Y+ A + + L ++ A +
Sbjct: 538 LLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADL 597
Query: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
+ +A + + + + + N +A +AL+L P D
Sbjct: 598 NRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPND----HS 653
Query: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
L F+ N L + ++ + A++ NP+ A N+ + H G A+ +YE +L
Sbjct: 654 LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISL 713
Query: 743 QLVPDSKLLKENLAKLDRLEKRLQE 767
QL P + KEN L R + +Q+
Sbjct: 714 QLDPTASGTKENYGLLRRKLELMQK 738
Score = 38.9 bits (89), Expect = 0.018
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 4/106 (3%)
Query: 669 ALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIK 728
AL + P + KV + G L ++ A YR AV+LNP A N+G I +
Sbjct: 474 ALSVCPLNAKV----HYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 529
Query: 729 GKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT 774
+ A A+Q+ PD NL + KR + + +T
Sbjct: 530 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 575
Score = 37.4 bits (85), Expect = 0.053
Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 3/97 (3%)
Query: 361 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR 420
E++ R ++ +P++ + ++ AN L + KE+ + A+K P AS NL L
Sbjct: 638 EAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYH 697
Query: 421 DTAE---AKMYYQRALQLHPQHNRALFNLGNLLKSQE 454
AK +Y+ +LQL P + N G L + E
Sbjct: 698 RWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLE 734
Score = 31.6 bits (70), Expect = 2.9
Identities = 20/67 (29%), Positives = 30/67 (44%)
Query: 704 YRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEK 763
+R A+ + P A+ N+G KG +A YY A++L P NL + +
Sbjct: 471 FRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERN 530
Query: 764 RLQEVRE 770
LQE E
Sbjct: 531 ELQEAEE 537
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 307 bits (786), Expect = 3e-83
Identities = 222/635 (34%), Positives = 325/635 (51%), Gaps = 48/635 (7%)
Query: 2 NPFYFHAVNIILHCLVTLVLMYTCDKTVF-------KNRGL------AFVTALLFAVHPI 48
+P FH VNI+LH ++ VLM +F K R L + + ALLFAVHP+
Sbjct: 122 HPVGFHVVNILLHSGIS-VLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPV 180
Query: 49 HTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAM 108
HTE VAG+VGRAD+L L FLL+FL Y ++ + G+ ST F++LLS+FLG AM
Sbjct: 181 HTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSST---FWVLLSIFLGAVAM 237
Query: 109 LVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGK- 167
L KE GITV G+ V+D+ + G Q + SL NG
Sbjct: 238 LCKEQGITVLGLNAVFDILVI---------GKFNVLEIVQKVLHKDKSLENLGMLRNGGL 288
Query: 168 --QQRFPHKGAWGGCH------SPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWL 219
+ G G + PP P S A ++R + Y+Y + N WL
Sbjct: 289 LFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPAS-FADSMLVRAVNYNYYYSLNAWL 347
Query: 220 LLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKE--VLV 277
LL P LC+DW +G IPL+++I D R +A A+ L+ L C A HK + +
Sbjct: 348 LLCPWWLCFDWSMGCIPLIKSISDWRVIA--LAALWFCLIGLICQALCSEDGHKRRILTL 405
Query: 278 GLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIV 337
GL FLV PF+PASNLFFRVGFVVAERVLY+PS+GYC+L G L + LI
Sbjct: 406 GLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKK---KKLIA 462
Query: 338 STVL-LLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIY 396
+ VL +L + + + V ++ W S E LFRS + P NAKVHYN L D+G AI
Sbjct: 463 AVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIR 522
Query: 397 HYRTALKLYPRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQ 453
+YR A++L P++ A+NNLG + + + EA+ A+Q+ P A NLG + S
Sbjct: 523 YYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSL 582
Query: 454 EKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNN 513
++ E A + +IK+ ++ D Y +L L A+ R +A ++ P+ S NN
Sbjct: 583 KRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNN 642
Query: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV-A 572
+ L +TG +A A ++A++L P+ H M +L + + +E + +A++
Sbjct: 643 MIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 702
Query: 573 HKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607
+ A L LY+ G + A + Y+ + L P+
Sbjct: 703 NAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPT 737
Score = 82.8 bits (203), Expect = 1e-15
Identities = 80/325 (24%), Positives = 146/325 (44%), Gaps = 14/325 (4%)
Query: 444 FNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKN 503
F G L K +KK+ L ++ G F + +L +L E ++ E+++++ +
Sbjct: 446 FGFGALSKHTKKKK-----LIAAVVLGILFIN---TLRCVLRSGE-WRSEEQLFRSALSV 496
Query: 504 CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEE 563
CP ++ +H N G L D G A+ +Y++A++L+P + AM NLG + + E AEE
Sbjct: 497 CPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEE 556
Query: 564 WYKRALQVAHK-AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVM 622
A+Q+ A LG + + R+E A Q Y+ A + + L ++ A +
Sbjct: 557 LLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADL 616
Query: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
+ +A + + + + + N +A +AL+L P D
Sbjct: 617 NRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPND----HS 672
Query: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
L F+ N L + ++ + A++ NP+ A N+ + H G A+ +YE +L
Sbjct: 673 LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISL 732
Query: 743 QLVPDSKLLKENLAKLDRLEKRLQE 767
QL P + KEN L R + +Q+
Sbjct: 733 QLDPTASGTKENYGLLRRKLELMQK 757
Score = 38.9 bits (89), Expect = 0.018
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 4/106 (3%)
Query: 669 ALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIK 728
AL + P + KV + G L ++ A YR AV+LNP A N+G I +
Sbjct: 493 ALSVCPLNAKV----HYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 548
Query: 729 GKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT 774
+ A A+Q+ PD NL + KR + + +T
Sbjct: 549 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 594
Score = 37.4 bits (85), Expect = 0.053
Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 3/97 (3%)
Query: 361 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR 420
E++ R ++ +P++ + ++ AN L + KE+ + A+K P AS NL L
Sbjct: 657 EAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYH 716
Query: 421 DTAE---AKMYYQRALQLHPQHNRALFNLGNLLKSQE 454
AK +Y+ +LQL P + N G L + E
Sbjct: 717 RWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLE 753
Score = 31.6 bits (70), Expect = 2.9
Identities = 20/67 (29%), Positives = 30/67 (44%)
Query: 704 YRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEK 763
+R A+ + P A+ N+G KG +A YY A++L P NL + +
Sbjct: 490 FRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERN 549
Query: 764 RLQEVRE 770
LQE E
Sbjct: 550 ELQEAEE 556
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 215 bits (547), Expect = 1e-55
Identities = 161/562 (28%), Positives = 272/562 (48%), Gaps = 65/562 (11%)
Query: 205 RFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCL 264
R LT++YLL N WLLL P LC DW +G+IPL+E++ D+RNLAT + +L + +
Sbjct: 279 RQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLGMLGVFSI 338
Query: 265 AAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLC 324
+ K VL+ L + PFIPASNLFF VGFVVAERVLY+PSMG+CIL HG K+
Sbjct: 339 R-YSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKIS 397
Query: 325 TWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANF 384
T + + +S +++L S KT +N W S +LF S ++ +NAK+ N +
Sbjct: 398 TKSVFKKLSWICLS--MVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHA 455
Query: 385 LKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRD---TAEAKMYYQRALQLHPQ--- 438
L+++ + A+ ++ A + P A N+G ++ T EA+ Y A L PQ
Sbjct: 456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIP 515
Query: 439 -----------HNRALFNLGNLLKSQEKK-EEAITLLKDSIKYGPEFADAYSSLASLLAE 486
H NL NL+++ E + EEA L + +I P+F AY S LL +
Sbjct: 516 GKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLK 575
Query: 487 QERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAM- 545
+ +A+E Y ++ +++DL N + ++ P +A+ ++ +A++L+P H +A+
Sbjct: 576 MNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALF 635
Query: 546 ------------------------------------VNLGRLYRSLGENSMAEEWYKRAL 569
NLG L +++ AE W K+A+
Sbjct: 636 NSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAI 695
Query: 570 QV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKE- 627
++ A L L LY T + +AL I +E P + + +L M Q K+
Sbjct: 696 KLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDIL--MNQKKDI 753
Query: 628 --AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685
A+K I+ + ++ L +Y ++++ KA + + L L P + + L
Sbjct: 754 LGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAPHEEYIQRHLNI 813
Query: 686 TKGNQLREQNLLDKAFESYRVA 707
+ +++ + ++ F + +++
Sbjct: 814 VR-DKISSSSFIEPIFPTSKIS 834
Score = 100 bits (249), Expect = 5e-21
Identities = 54/127 (42%), Positives = 80/127 (62%), Gaps = 9/127 (7%)
Query: 1 MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60
+ P +H +N+I H +V+++ + C +F + + + +LLFAVHPIHTEAV G+VGRA
Sbjct: 87 LKPMSYHLLNMIFHAVVSVIFLKVCK--LFLDNKSSVIASLLFAVHPIHTEAVTGVVGRA 144
Query: 61 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120
++L+ + FL AFLSY RS G +P + L++FL A L KE GITV G+
Sbjct: 145 ELLSSIFFLAAFLSYTRS-----KGPDNSIIWTP--IALTVFLVAVATLCKEQGITVVGI 197
Query: 121 CLVYDLF 127
C VY++F
Sbjct: 198 CCVYEVF 204
Score = 70.9 bits (172), Expect = 4e-12
Identities = 62/281 (22%), Positives = 131/281 (46%), Gaps = 21/281 (7%)
Query: 496 IYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSL 555
++ + +K +++ L NN G L + E+A+ ++ QA + P A +N+GR Y++L
Sbjct: 434 LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNL 493
Query: 556 GENSMAEEWY--------------KRALQVA--HKAEILSPLGALYYNTGRYEEALQIYQ 599
AEE Y K A ++A H ++ + N R EEA Q+Y+
Sbjct: 494 NRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYR 553
Query: 600 EAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENH 659
+A +++P ++ ++ ++L M + +A++ + + + + L+ ++ + +
Sbjct: 554 QAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEP 613
Query: 660 DKALDAIDKALQLKPKDPKVI--SELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQA 717
++AL ++AL+L PK + S + + +++ + K SY + P A
Sbjct: 614 NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSY---INEEPLDANG 670
Query: 718 WMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKL 758
+ N+G + K A + ++A++L D + NLA L
Sbjct: 671 YFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALL 711
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 162 bits (410), Expect = 1e-39
Identities = 135/445 (30%), Positives = 204/445 (45%), Gaps = 30/445 (6%)
Query: 275 VLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATT 334
V++ L L+ PF+PA+NLFF VGFV+AERVLY+PSMG+C+L G L + + +
Sbjct: 394 VVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKS 453
Query: 335 LI-VSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKE 393
LI +T L++ + KT +N W + E L+RSG++ P AK N N LK Q + E
Sbjct: 454 LIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISE 511
Query: 394 AIYHYRTALKLYPRHASALNNLGTLTRDT---AEAKMYYQRALQLHPQHNRALFNLGNLL 450
A YR AL A L NLG L ++ AEA YY+ A+ P A N G +L
Sbjct: 512 AESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIIL 571
Query: 451 KSQEKKEEAITL-----------LKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQT 499
+Q + EEA LKD + +L L EQ ++EA +Y+
Sbjct: 572 MNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKE 631
Query: 500 GIKNCPDS---SDLHNNYG-VFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSL 555
I+ P L+N G ++ + LPE A Y ++++ H A + G+L
Sbjct: 632 AIQKMPRQFAPQSLYNMMGEAYMRLSKLPE-AEHWYMESLRSKTDHIPAHLTYGKLLALT 690
Query: 556 GENSMAEEWYKRALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLA 614
G S AE+ + +A+++ K G R EA ++ ++AA L ++ ++
Sbjct: 691 GRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFN 750
Query: 615 LAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKP 674
A +L + AEK + L AI KA +ALQLKP
Sbjct: 751 AAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKP 810
Query: 675 KDPKVISELFFTKGNQLREQNLLDK 699
D T+ N + N+++K
Sbjct: 811 DD-------VITQSNLRKLWNIMEK 828
Score = 138 bits (348), Expect = 2e-32
Identities = 111/393 (28%), Positives = 183/393 (46%), Gaps = 27/393 (6%)
Query: 382 ANFLKDQGRNKEAIYHYRTA-LKLYPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHN 440
A ++K Q R +++ Y TA L ++ +A+ N D +M Y+ ++++P
Sbjct: 441 ALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRN-----GDWQNEEMLYRSGIKVNPA-- 493
Query: 441 RALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTG 500
+A NLGN+LKSQ K EA + ++++ Y AD +L LL E RF EA Y+
Sbjct: 494 KAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLA 553
Query: 501 IKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKL------SPSHHVAMV-----NLG 549
I + P + + N G+ L++ G E+A + + ++ P H + V NLG
Sbjct: 554 IGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLG 613
Query: 550 RLYRSLGENSMAEEWYKRALQVAHKA----EILSPLGALYYNTGRYEEALQIYQEAAALQ 605
+LY G A YK A+Q + + + +G Y + EA Y E+ +
Sbjct: 614 KLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSK 673
Query: 606 PSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDA 665
L ++LA+ G+ EAEK+ + + CY ++ +A +
Sbjct: 674 TDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEM 733
Query: 666 IDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQ 725
KA +L + V+ F + LR+ +L + A + Y +A +L P+ A MN+G I
Sbjct: 734 AKKAAELDSTEFDVV----FNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAIL 789
Query: 726 HIKGKYVSARAYYERALQLVPDSKLLKENLAKL 758
H+ G+ A A Y RALQL PD + + NL KL
Sbjct: 790 HLNGRLQKAEANYLRALQLKPDDVITQSNLRKL 822
Score = 122 bits (307), Expect = 1e-27
Identities = 95/270 (35%), Positives = 133/270 (49%), Gaps = 29/270 (10%)
Query: 1 MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60
+NP+ +H VN++LH VT L + K + + F+ L+FA HPIHTEAVAGIVGRA
Sbjct: 82 LNPWSYHLVNVLLHAAVT-GLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRA 140
Query: 61 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120
DV A L FLL+ L Y + C + + +FL L G C+ML KE G+TV V
Sbjct: 141 DVGASLFFLLSLLCYIKH----CSTRGYSARTWGWFLGSGLCAG-CSMLWKEQGVTVLAV 195
Query: 121 CLVYDLFSLSNKQDKSSNGALCPRSPQQPGSP------QPSSLPGHPHRENGKQQRFPHK 174
VYD+F + K + R SSL G +
Sbjct: 196 SAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLG-------------AR 242
Query: 175 GAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGS 234
W G PP +S P + + + R LT+ YL N+WLLL P TL +DW + +
Sbjct: 243 LYWMG---NKPPSFSNSDNPAAD-SDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDA 298
Query: 235 IPLVETIWDMRNLATIFLAVVMALLSLHCL 264
+PL++T+ D RNL T+ + LL+ + L
Sbjct: 299 VPLLKTVCDWRNLHTVAFYTGLLLLAYYGL 328
Score = 52.4 bits (124), Expect = 2e-06
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 40/222 (18%)
Query: 379 YNYANFLKDQGRNKEAIYHYRTALKLYPRH---ASALNNLGTLTRDTA---EAKMYYQRA 432
YN +QG +EA+ Y+ A++ PR S N +G + EA+ +Y +
Sbjct: 610 YNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMES 669
Query: 433 LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKE 492
L+ H A G LL +K EA L +I+ P + Y L E+ R E
Sbjct: 670 LRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIE 729
Query: 493 AEEI----------------------------------YQTGIKNCPDSSDLHNNYGVFL 518
A E+ Y + P+ N G L
Sbjct: 730 AAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAIL 789
Query: 519 VDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSM 560
G +KA A+Y +A++L P + NL +L+ + + +
Sbjct: 790 HLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGL 831
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 139 bits (350), Expect = 1e-32
Identities = 112/395 (28%), Positives = 179/395 (45%), Gaps = 9/395 (2%)
Query: 358 LSRESLFRS-GVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLG 416
L R + F + ++ P A+ + N N K++G+ +EAI HYR AL+L P NL
Sbjct: 61 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 120
Query: 417 TL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEF 473
D A Y ALQ +P +LGNLLK+ + EEA +I+ P F
Sbjct: 121 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 180
Query: 474 ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQ 533
A A+S+L + Q A ++ + P+ D + N G L + + ++AVA Y +
Sbjct: 181 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLR 240
Query: 534 AIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVA-HKAEILSPLGALYYNTGRYE 592
A+ LSP+H V NL +Y G +A + Y+RA+++ H + L G
Sbjct: 241 ALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA 300
Query: 593 EALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAI 652
EA Y A L P+ + LA + G +EA ++ + + L+++
Sbjct: 301 EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASV 360
Query: 653 YSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712
+Q +AL +A+++ P ++ + GN L+E + A + Y A+Q+NP
Sbjct: 361 LQQQGKLQEALMHYKEAIRISP----TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINP 416
Query: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPD 747
A A N+ I G A A Y AL+L PD
Sbjct: 417 AFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
Score = 122 bits (306), Expect = 1e-27
Identities = 104/378 (27%), Positives = 169/378 (44%), Gaps = 9/378 (2%)
Query: 388 QGRNKEAIYHYRT-ALKLYPRHASALNNLGTLTRDTA---EAKMYYQRALQLHPQHNRAL 443
Q R + H+ T A+K P A A +NLG + ++ EA +Y+ AL+L P
Sbjct: 57 QCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGY 116
Query: 444 FNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKN 503
NL L + E A+ +++Y P+ S L +LL R +EA+ Y I+
Sbjct: 117 INLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 176
Query: 504 CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEE 563
P+ + +N G G A+ H+++A+ L P+ A +NLG + + A
Sbjct: 177 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVA 236
Query: 564 WYKRALQVA-HKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVM 622
Y RAL ++ + A + L +YY G + A+ Y+ A LQP + LA L
Sbjct: 237 AYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK 296
Query: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
G EAE N + + L+ I +Q N ++A+ KAL++ P+ S
Sbjct: 297 GSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSN 356
Query: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
L + L++Q L +A Y+ A++++P A A+ NMG A Y RA+
Sbjct: 357 L----ASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI 412
Query: 743 QLVPDSKLLKENLAKLDR 760
Q+ P NLA + +
Sbjct: 413 QINPAFADAHSNLASIHK 430
Score = 118 bits (296), Expect = 2e-26
Identities = 70/211 (33%), Positives = 115/211 (54%), Gaps = 3/211 (1%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTA 423
+R ++ PH + N AN LK++G EA Y TAL+L P HA +LNNL + R+
Sbjct: 272 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 331
Query: 424 ---EAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
EA Y++AL++ P+ A NL ++L+ Q K +EA+ K++I+ P FADAYS++
Sbjct: 332 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
+ L E + + A + Y I+ P +D H+N D+G +A+A Y+ A+KL P
Sbjct: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
Query: 541 HHVAMVNLGRLYRSLGENSMAEEWYKRALQV 571
A NL + + + + +E K+ + +
Sbjct: 452 FPDAYCNLAHCLQIVCDWTDYDERMKKLVSI 482
Score = 117 bits (292), Expect = 5e-26
Identities = 85/302 (28%), Positives = 144/302 (47%), Gaps = 5/302 (1%)
Query: 353 QNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASAL 412
Q EIWL+ F V P+ + N N LK+ A+ Y AL L P HA
Sbjct: 194 QGEIWLAIHH-FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH 252
Query: 413 NNLGTLTRDTAEAKMY---YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKY 469
NL + + + Y+RA++L P A NL N LK + EA +++
Sbjct: 253 GNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRL 312
Query: 470 GPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVA 529
P AD+ ++LA++ EQ +EA +Y+ ++ P+ + H+N L G ++A+
Sbjct: 313 CPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALM 372
Query: 530 HYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHK-AEILSPLGALYYNT 588
HY++AI++SP+ A N+G + + + A + Y RA+Q+ A+ S L +++ ++
Sbjct: 373 HYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDS 432
Query: 589 GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRL 648
G EA+ Y+ A L+P + LA L ++ + ++ +VS LE RL
Sbjct: 433 GNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRL 492
Query: 649 LS 650
S
Sbjct: 493 PS 494
Score = 110 bits (274), Expect = 6e-24
Identities = 91/356 (25%), Positives = 161/356 (45%), Gaps = 21/356 (5%)
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
D A+ + + + P + L L ++ + + + +IK P A+AYS+L
Sbjct: 26 DFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNL 85
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
++ E+ + +EA E Y+ ++ PD D + N LV G E AV Y A++ +P
Sbjct: 86 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 145
Query: 541 HHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEIL-SPLGALYYNTGRYEEALQIYQ 599
+ +LG L ++LG A+ Y +A++ + S LG ++ G A+ ++
Sbjct: 146 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFE 205
Query: 600 EAAALQPSQRELRLALAQVL--------AVMGQTKEAEKMTNHIVSEETGCLECYRLLSA 651
+A L P+ + + L VL AV + NH V G L C
Sbjct: 206 KAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH--GNLAC------ 257
Query: 652 IYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLN 711
+Y +Q D A+D +A++L+P P L N L+E+ + +A + Y A++L
Sbjct: 258 VYYEQGLIDLAIDTYRRAIELQPHFPDAYCNL----ANALKEKGSVAEAEDCYNTALRLC 313
Query: 712 PDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQE 767
P A + N+ I+ +G A Y +AL++ P+ NLA + + + +LQE
Sbjct: 314 PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQE 369
Score = 103 bits (258), Expect = 5e-22
Identities = 71/224 (31%), Positives = 119/224 (53%), Gaps = 3/224 (1%)
Query: 351 VKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHAS 410
+K+ I+ + + + P++A VH N A +QG AI YR A++L P
Sbjct: 225 LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284
Query: 411 ALNNLGTLTRD---TAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSI 467
A NL ++ AEA+ Y AL+L P H +L NL N+ + Q EEA+ L + ++
Sbjct: 285 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 344
Query: 468 KYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKA 527
+ PEFA A+S+LAS+L +Q + +EA Y+ I+ P +D ++N G L + + A
Sbjct: 345 EVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGA 404
Query: 528 VAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV 571
+ Y +AI+++P+ A NL +++ G A Y+ AL++
Sbjct: 405 LQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKL 448
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 4/147 (2%)
Query: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
G + AE+ + +E LLS+I+ + D++ A++ P +++E
Sbjct: 25 GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNP----LLAE 80
Query: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
+ GN +E+ L +A E YR A++L PD ++N+ G A Y AL
Sbjct: 81 AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
Query: 743 QLVPDSKLLKENLAKLDRLEKRLQEVR 769
Q PD ++ +L L + RL+E +
Sbjct: 141 QYNPDLYCVRSDLGNLLKALGRLEEAK 167
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 139 bits (350), Expect = 1e-32
Identities = 112/395 (28%), Positives = 179/395 (45%), Gaps = 9/395 (2%)
Query: 358 LSRESLFRS-GVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLG 416
L R + F + ++ P A+ + N N K++G+ +EAI HYR AL+L P NL
Sbjct: 71 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 130
Query: 417 TL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEF 473
D A Y ALQ +P +LGNLLK+ + EEA +I+ P F
Sbjct: 131 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 190
Query: 474 ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQ 533
A A+S+L + Q A ++ + P+ D + N G L + + ++AVA Y +
Sbjct: 191 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLR 250
Query: 534 AIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVA-HKAEILSPLGALYYNTGRYE 592
A+ LSP+H V NL +Y G +A + Y+RA+++ H + L G
Sbjct: 251 ALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA 310
Query: 593 EALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAI 652
EA Y A L P+ + LA + G +EA ++ + + L+++
Sbjct: 311 EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASV 370
Query: 653 YSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712
+Q +AL +A+++ P ++ + GN L+E + A + Y A+Q+NP
Sbjct: 371 LQQQGKLQEALMHYKEAIRISP----TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINP 426
Query: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPD 747
A A N+ I G A A Y AL+L PD
Sbjct: 427 AFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461
Score = 122 bits (306), Expect = 1e-27
Identities = 104/378 (27%), Positives = 169/378 (44%), Gaps = 9/378 (2%)
Query: 388 QGRNKEAIYHYRT-ALKLYPRHASALNNLGTLTRDTA---EAKMYYQRALQLHPQHNRAL 443
Q R + H+ T A+K P A A +NLG + ++ EA +Y+ AL+L P
Sbjct: 67 QCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGY 126
Query: 444 FNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKN 503
NL L + E A+ +++Y P+ S L +LL R +EA+ Y I+
Sbjct: 127 INLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 186
Query: 504 CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEE 563
P+ + +N G G A+ H+++A+ L P+ A +NLG + + A
Sbjct: 187 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVA 246
Query: 564 WYKRALQVA-HKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVM 622
Y RAL ++ + A + L +YY G + A+ Y+ A LQP + LA L
Sbjct: 247 AYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK 306
Query: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
G EAE N + + L+ I +Q N ++A+ KAL++ P+ S
Sbjct: 307 GSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSN 366
Query: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
L + L++Q L +A Y+ A++++P A A+ NMG A Y RA+
Sbjct: 367 L----ASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI 422
Query: 743 QLVPDSKLLKENLAKLDR 760
Q+ P NLA + +
Sbjct: 423 QINPAFADAHSNLASIHK 440
Score = 118 bits (296), Expect = 2e-26
Identities = 70/211 (33%), Positives = 115/211 (54%), Gaps = 3/211 (1%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTA 423
+R ++ PH + N AN LK++G EA Y TAL+L P HA +LNNL + R+
Sbjct: 282 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 341
Query: 424 ---EAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
EA Y++AL++ P+ A NL ++L+ Q K +EA+ K++I+ P FADAYS++
Sbjct: 342 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 401
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
+ L E + + A + Y I+ P +D H+N D+G +A+A Y+ A+KL P
Sbjct: 402 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461
Query: 541 HHVAMVNLGRLYRSLGENSMAEEWYKRALQV 571
A NL + + + + +E K+ + +
Sbjct: 462 FPDAYCNLAHCLQIVCDWTDYDERMKKLVSI 492
Score = 117 bits (292), Expect = 5e-26
Identities = 85/302 (28%), Positives = 144/302 (47%), Gaps = 5/302 (1%)
Query: 353 QNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASAL 412
Q EIWL+ F V P+ + N N LK+ A+ Y AL L P HA
Sbjct: 204 QGEIWLAIHH-FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH 262
Query: 413 NNLGTLTRDTAEAKMY---YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKY 469
NL + + + Y+RA++L P A NL N LK + EA +++
Sbjct: 263 GNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRL 322
Query: 470 GPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVA 529
P AD+ ++LA++ EQ +EA +Y+ ++ P+ + H+N L G ++A+
Sbjct: 323 CPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALM 382
Query: 530 HYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHK-AEILSPLGALYYNT 588
HY++AI++SP+ A N+G + + + A + Y RA+Q+ A+ S L +++ ++
Sbjct: 383 HYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDS 442
Query: 589 GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRL 648
G EA+ Y+ A L+P + LA L ++ + ++ +VS LE RL
Sbjct: 443 GNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRL 502
Query: 649 LS 650
S
Sbjct: 503 PS 504
Score = 110 bits (274), Expect = 6e-24
Identities = 91/356 (25%), Positives = 161/356 (45%), Gaps = 21/356 (5%)
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
D A+ + + + P + L L ++ + + + +IK P A+AYS+L
Sbjct: 36 DFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNL 95
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
++ E+ + +EA E Y+ ++ PD D + N LV G E AV Y A++ +P
Sbjct: 96 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 155
Query: 541 HHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEIL-SPLGALYYNTGRYEEALQIYQ 599
+ +LG L ++LG A+ Y +A++ + S LG ++ G A+ ++
Sbjct: 156 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFE 215
Query: 600 EAAALQPSQRELRLALAQVL--------AVMGQTKEAEKMTNHIVSEETGCLECYRLLSA 651
+A L P+ + + L VL AV + NH V G L C
Sbjct: 216 KAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH--GNLAC------ 267
Query: 652 IYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLN 711
+Y +Q D A+D +A++L+P P L N L+E+ + +A + Y A++L
Sbjct: 268 VYYEQGLIDLAIDTYRRAIELQPHFPDAYCNL----ANALKEKGSVAEAEDCYNTALRLC 323
Query: 712 PDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQE 767
P A + N+ I+ +G A Y +AL++ P+ NLA + + + +LQE
Sbjct: 324 PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQE 379
Score = 103 bits (258), Expect = 5e-22
Identities = 71/224 (31%), Positives = 119/224 (53%), Gaps = 3/224 (1%)
Query: 351 VKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHAS 410
+K+ I+ + + + P++A VH N A +QG AI YR A++L P
Sbjct: 235 LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 294
Query: 411 ALNNLGTLTRD---TAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSI 467
A NL ++ AEA+ Y AL+L P H +L NL N+ + Q EEA+ L + ++
Sbjct: 295 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 354
Query: 468 KYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKA 527
+ PEFA A+S+LAS+L +Q + +EA Y+ I+ P +D ++N G L + + A
Sbjct: 355 EVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGA 414
Query: 528 VAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV 571
+ Y +AI+++P+ A NL +++ G A Y+ AL++
Sbjct: 415 LQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKL 458
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 4/147 (2%)
Query: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
G + AE+ + +E LLS+I+ + D++ A++ P +++E
Sbjct: 35 GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNP----LLAE 90
Query: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
+ GN +E+ L +A E YR A++L PD ++N+ G A Y AL
Sbjct: 91 AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 150
Query: 743 QLVPDSKLLKENLAKLDRLEKRLQEVR 769
Q PD ++ +L L + RL+E +
Sbjct: 151 QYNPDLYCVRSDLGNLLKALGRLEEAK 177
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 67.4 bits (163), Expect = 5e-11
Identities = 70/281 (24%), Positives = 123/281 (43%), Gaps = 48/281 (17%)
Query: 372 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQR 431
P+ A+ A + Q + ++A + + + K+ H A+ G L + +R
Sbjct: 1024 PYTARELEALATLYQKQNKYEQAEHFRKKSFKI---HQKAIKKKGNLYGFA----LLRRR 1076
Query: 432 ALQLH--------PQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYG--------PEFAD 475
ALQL P + R L LG L Q E A LK S++ P+ A
Sbjct: 1077 ALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQ 1136
Query: 476 AYSSLASLLAEQERFKEAEEIYQTGI-----KNCPDSSDLH---NNYGVFLVDTGLPEKA 527
+ ++LA+L E++++ +AEE+Y+ + PD L + + G +KA
Sbjct: 1137 SLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKA 1196
Query: 528 VAHYQQAIKL--------SPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKA---- 575
V Y+ A+++ PS A+VNL LY + ++ A Y+RAL++ +
Sbjct: 1197 VPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRM 1256
Query: 576 -----EILSPLGALYYNTGRYEEALQIYQEAAALQPSQREL 611
E L L L Y G +E+A ++Y+ A ++ ++ L
Sbjct: 1257 HPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSL 1297
Score = 57.4 bits (137), Expect = 5e-08
Identities = 74/322 (22%), Positives = 129/322 (40%), Gaps = 75/322 (23%)
Query: 502 KNCPDS------SDLHNNYGVFLVDTGLPEKAVAHYQQAIK-----LSPSHHVAMVNLGR 550
KNC +DL+ G FL D GL +A+ Q++++ L P H +L +
Sbjct: 931 KNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQ 990
Query: 551 L---YRSLGENSMAEEWYKRALQVA---------HKAEILSPLGALYYNTGRYEEA---- 594
L Y + AE+ YK+AL+++ + A L L LY +YE+A
Sbjct: 991 LASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFR 1050
Query: 595 ---LQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETG---------- 641
+I+Q+A + + L + L + T + N E G
Sbjct: 1051 KKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLE 1110
Query: 642 -----------------------CLECYRLLSAIYSKQENHDKALDAIDKALQLKPKD-- 676
C + L+A+ ++++ +DKA + ++AL ++ +
Sbjct: 1111 TADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALA 1170
Query: 677 PKVISELFFTKGNQL--REQNLLDKAFESYRVAVQL--------NPDQAQAWMNMGGIQH 726
P S + K + ++ LDKA Y +AV++ +P A A +N+ +
Sbjct: 1171 PDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYS 1230
Query: 727 IKGKYVSARAYYERALQLVPDS 748
K+V A YERAL++ DS
Sbjct: 1231 QMKKHVEALPLYERALKIYEDS 1252
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 65.1 bits (157), Expect = 2e-10
Identities = 55/239 (23%), Positives = 107/239 (44%), Gaps = 4/239 (1%)
Query: 409 ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIK 468
A+ L+ L + +D A+A Y A+ + AL N GN + + E+A K++++
Sbjct: 462 ATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALR 521
Query: 469 YGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAV 528
+A ++ + R EA + + +S+++ P +A+
Sbjct: 522 NDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAI 581
Query: 529 AHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH-KAEILSPLGALYYN 587
Q + + P+ + LG LY G+ S A ++Y + + E++ LGA Y +
Sbjct: 582 EWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID 641
Query: 588 TGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEA---EKMTNHIVSEETGCL 643
T +E+A+Q ++ A+ +QP+Q + +L +A G ++A K T+ E CL
Sbjct: 642 TQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECL 700
Score = 47.0 bits (110), Expect = 7e-05
Identities = 41/197 (20%), Positives = 75/197 (38%), Gaps = 3/197 (1%)
Query: 373 HNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA 432
+N N N + G ++A Y+ AL+ AL N+G
Sbjct: 491 YNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCF 550
Query: 433 LQLHP---QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQER 489
L+LH L+ + N+ + E +AI L + P S L L +
Sbjct: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
Query: 490 FKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLG 549
+A + Y + P + ++ G + +DT EKA+ ++++A + P+ + +
Sbjct: 611 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 670
Query: 550 RLYRSLGENSMAEEWYK 566
+R G A + YK
Sbjct: 671 SCFRRSGNYQKALDTYK 687
Score = 42.4 bits (98), Expect = 0.002
Identities = 88/432 (20%), Positives = 161/432 (37%), Gaps = 68/432 (15%)
Query: 380 NYANFLKDQGRNKEAIYHYRTALKLYPR-----HASALNNLGTL---TRDTAEAKMYYQR 431
N N Q +AI YR AL P + N+G ++A Y+
Sbjct: 247 NMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEH 306
Query: 432 ALQLHPQ----HNRAL--FNLGNLLKSQEKKEEAIT--LLKDSIKYGPEFADAYSSLASL 483
+ + P +N + F +G+ K ++ ++ IT L D KY D +++L +
Sbjct: 307 IMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTE 366
Query: 484 LA--------EQERFKEAEEIYQTGIK---------------------NCPDSSDLHNNY 514
E+ER AE+ T K +L N+
Sbjct: 367 AIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDL 426
Query: 515 GVFLVDTGLPEKAVAHYQQAIKL--------SPSHHVAMVNLGRLYRSLGENSMAEEWYK 566
+ T L +K Y QA+++ S A NL LY + + A +
Sbjct: 427 EINKAVTYLRQK---DYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD 483
Query: 567 RALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQT 625
A+ + L+ G + G YE+A + Y+EA S E + + +
Sbjct: 484 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 543
Query: 626 KEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685
EA + + E ++ IY EN +A++ + + + + P DP+V+S+L
Sbjct: 544 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKL-- 601
Query: 686 TKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLV 745
G + +AF+ Y + + P N+ I+ + Y+ + ++E+A+Q
Sbjct: 602 --GELYDREGDKSQAFQYYYESYRYFP------CNIEVIEWLGAYYIDTQ-FWEKAIQYF 652
Query: 746 PDSKLLKENLAK 757
+ L++ K
Sbjct: 653 ERASLIQPTQVK 664
Score = 34.3 bits (77), Expect = 0.45
Identities = 30/156 (19%), Positives = 62/156 (39%), Gaps = 15/156 (9%)
Query: 368 VQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTA---E 424
V +P + +V +G +A +Y + + +P + + LG DT +
Sbjct: 588 VSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEK 647
Query: 425 AKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLL 484
A Y++RA + P + + + + ++A+ KD+ + PE + L L
Sbjct: 648 AIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLC 707
Query: 485 AE------------QERFKEAEEIYQTGIKNCPDSS 508
+ +R ++ +EI + IK+ D S
Sbjct: 708 TDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGS 743
Score = 33.1 bits (74), Expect = 1.0
Identities = 32/129 (24%), Positives = 55/129 (42%), Gaps = 7/129 (5%)
Query: 479 SLASLLAEQERFKEAEEIYQTGIKN--CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK 536
+LAS + E + EA YQ +KN ++ L N G + KA+ Y+ A+
Sbjct: 211 NLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALD 270
Query: 537 LSPSHH-----VAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRY 591
PS + M N+G + G+ S A Y+ + +A + L Y+ G
Sbjct: 271 QVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDR 330
Query: 592 EEALQIYQE 600
E+ + +Q+
Sbjct: 331 EKMKKAFQK 339
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 65.1 bits (157), Expect = 2e-10
Identities = 55/239 (23%), Positives = 107/239 (44%), Gaps = 4/239 (1%)
Query: 409 ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIK 468
A+ L+ L + +D A+A Y A+ + AL N GN + + E+A K++++
Sbjct: 453 ATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALR 512
Query: 469 YGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAV 528
+A ++ + R EA + + +S+++ P +A+
Sbjct: 513 NDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAI 572
Query: 529 AHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH-KAEILSPLGALYYN 587
Q + + P+ + LG LY G+ S A ++Y + + E++ LGA Y +
Sbjct: 573 EWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID 632
Query: 588 TGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEA---EKMTNHIVSEETGCL 643
T +E+A+Q ++ A+ +QP+Q + +L +A G ++A K T+ E CL
Sbjct: 633 TQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECL 691
Score = 47.0 bits (110), Expect = 7e-05
Identities = 41/197 (20%), Positives = 75/197 (38%), Gaps = 3/197 (1%)
Query: 373 HNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA 432
+N N N + G ++A Y+ AL+ AL N+G
Sbjct: 482 YNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCF 541
Query: 433 LQLHP---QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQER 489
L+LH L+ + N+ + E +AI L + P S L L +
Sbjct: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
Query: 490 FKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLG 549
+A + Y + P + ++ G + +DT EKA+ ++++A + P+ + +
Sbjct: 602 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 661
Query: 550 RLYRSLGENSMAEEWYK 566
+R G A + YK
Sbjct: 662 SCFRRSGNYQKALDTYK 678
Score = 42.4 bits (98), Expect = 0.002
Identities = 88/432 (20%), Positives = 161/432 (37%), Gaps = 68/432 (15%)
Query: 380 NYANFLKDQGRNKEAIYHYRTALKLYPR-----HASALNNLGTL---TRDTAEAKMYYQR 431
N N Q +AI YR AL P + N+G ++A Y+
Sbjct: 238 NMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEH 297
Query: 432 ALQLHPQ----HNRAL--FNLGNLLKSQEKKEEAIT--LLKDSIKYGPEFADAYSSLASL 483
+ + P +N + F +G+ K ++ ++ IT L D KY D +++L +
Sbjct: 298 IMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTE 357
Query: 484 LA--------EQERFKEAEEIYQTGIK---------------------NCPDSSDLHNNY 514
E+ER AE+ T K +L N+
Sbjct: 358 AIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDL 417
Query: 515 GVFLVDTGLPEKAVAHYQQAIKL--------SPSHHVAMVNLGRLYRSLGENSMAEEWYK 566
+ T L +K Y QA+++ S A NL LY + + A +
Sbjct: 418 EINKAVTYLRQK---DYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD 474
Query: 567 RALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQT 625
A+ + L+ G + G YE+A + Y+EA S E + + +
Sbjct: 475 IAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRL 534
Query: 626 KEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685
EA + + E ++ IY EN +A++ + + + + P DP+V+S+L
Sbjct: 535 DEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKL-- 592
Query: 686 TKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLV 745
G + +AF+ Y + + P N+ I+ + Y+ + ++E+A+Q
Sbjct: 593 --GELYDREGDKSQAFQYYYESYRYFP------CNIEVIEWLGAYYIDTQ-FWEKAIQYF 643
Query: 746 PDSKLLKENLAK 757
+ L++ K
Sbjct: 644 ERASLIQPTQVK 655
Score = 34.3 bits (77), Expect = 0.45
Identities = 30/156 (19%), Positives = 62/156 (39%), Gaps = 15/156 (9%)
Query: 368 VQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTA---E 424
V +P + +V +G +A +Y + + +P + + LG DT +
Sbjct: 579 VSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEK 638
Query: 425 AKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLL 484
A Y++RA + P + + + + ++A+ KD+ + PE + L L
Sbjct: 639 AIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLC 698
Query: 485 AE------------QERFKEAEEIYQTGIKNCPDSS 508
+ +R ++ +EI + IK+ D S
Sbjct: 699 TDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGS 734
Score = 33.1 bits (74), Expect = 1.0
Identities = 32/129 (24%), Positives = 55/129 (42%), Gaps = 7/129 (5%)
Query: 479 SLASLLAEQERFKEAEEIYQTGIKN--CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK 536
+LAS + E + EA YQ +KN ++ L N G + KA+ Y+ A+
Sbjct: 202 NLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALD 261
Query: 537 LSPSHH-----VAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRY 591
PS + M N+G + G+ S A Y+ + +A + L Y+ G
Sbjct: 262 QVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDR 321
Query: 592 EEALQIYQE 600
E+ + +Q+
Sbjct: 322 EKMKKAFQK 330
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 64.7 bits (156), Expect = 3e-10
Identities = 82/366 (22%), Positives = 145/366 (39%), Gaps = 48/366 (13%)
Query: 417 TLTRDTAEAKMYYQRALQLHPQHNRA---LFNLGNLLKSQEKKEEAITLLKDSIKYGPEF 473
TL + + K Y + A LH +++ L+ L ++KK++ ++ G
Sbjct: 88 TLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVK 147
Query: 474 ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQ 533
+A L L E + +A E+ G+ YGV L L ++A+ + +
Sbjct: 148 NEA---LRELRVELSKKHQARELDGFGLYL----------YGVVLRKLDLVKEAIDVFVE 194
Query: 534 AIKLSPSHHVAMVNLGRLYRS---LGENSMAEEWYKR---------------ALQ----- 570
A + P H A + L L L S+ + W K ALQ
Sbjct: 195 ATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNL 254
Query: 571 ----VAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTK 626
+ + I+S + Y+N ++AL I+ E P + E + +L V
Sbjct: 255 IDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKS 314
Query: 627 EAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFT 686
E + +++ + +E ++ YS + H+KA +AL+L P+ +
Sbjct: 315 ELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPR----YLGAWTL 370
Query: 687 KGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVP 746
G++ E A ++YR A+++N +AW +G I YY RA QL P
Sbjct: 371 MGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRP 430
Query: 747 -DSKLL 751
DS++L
Sbjct: 431 NDSRML 436
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/223 (21%), Positives = 88/223 (39%), Gaps = 10/223 (4%)
Query: 412 LNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGP 471
+ N +L +A +Y+QRAL+L+P++ A +G+ + AI + +I+
Sbjct: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
Query: 472 EFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHY 531
A+ L + Y+ + P+ S + G +A Y
Sbjct: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCY 456
Query: 532 QQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQ--------VAHKAE--ILSPL 581
+A + +A+V L +L+ L E+ A + Y + +Q V H E L
Sbjct: 457 WRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYL 516
Query: 582 GALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQ 624
Y+ ++EA Q+ A ++ E + L Q+L + Q
Sbjct: 517 AQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQ 559
>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
sapiens]
Length = 599
Score = 62.8 bits (151), Expect = 1e-09
Identities = 93/433 (21%), Positives = 160/433 (36%), Gaps = 54/433 (12%)
Query: 367 GVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAK 426
G+ + K++ AN K G+ + ++ Y+ L+ P A+ L +L+ AE
Sbjct: 161 GIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVA 220
Query: 427 MYYQRALQLHPQ------------------HNRALFNLGNLLKSQEKKEEAITLLKDSIK 468
+Q P ++RA+ + +L EKK +LL+D++
Sbjct: 221 SMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSL----EKK----SLLRDNVD 272
Query: 469 YGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAV 528
AD Y +F++A+ + IK + YG L G E
Sbjct: 273 LLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGM-------DVYGYLLAREGRLEDVE 325
Query: 529 AHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKA--------EILSP 580
+ +S H V G +S + Y RAL + KA + L
Sbjct: 326 NLGCRLFNISDQHAEPWVVSGC-------HSFYSKRYSRALYLGAKAIQLNSNSVQALLL 378
Query: 581 LGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEET 640
GA N GR +EA+ ++EA L P + + L + +EA M N++
Sbjct: 379 KGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLG 438
Query: 641 GCLECYRLLSAIYSKQE-NHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDK 699
+ LL+ + + +KA +DKAL +P K + + K L + +
Sbjct: 439 ANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVK----KAELLSREQKYED 494
Query: 700 AFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLD 759
R A+ N +G +Y A Y AL L P+ + E + K++
Sbjct: 495 GIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKME 553
Query: 760 RLEKRLQEVREKD 772
+ E +E+D
Sbjct: 554 KEESPTDATQEED 566
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 62.8 bits (151), Expect = 1e-09
Identities = 54/209 (25%), Positives = 92/209 (44%), Gaps = 15/209 (7%)
Query: 406 PRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKD 465
P A N +L R+ A ++QRA+Q+ P + A LG+ E+ ++A+ ++
Sbjct: 573 PEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRN 632
Query: 466 SIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPE 525
+I+ P +A+ L + +QE+F AE +Q + P SS L + GV E
Sbjct: 633 AIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSE 692
Query: 526 KAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSP----- 580
KA+ +AI + P + + + + A E YK ALQ + + + P
Sbjct: 693 KALDTLNKAIVIDPKNPLCKFHRASVL-------FANEKYKSALQELEELKQIVPKESLV 745
Query: 581 ---LGALYYNTGRYEEALQIYQEAAALQP 606
+G +Y G+ AL + A L P
Sbjct: 746 YFLIGKVYKKLGQTHLALMNFSWAMDLDP 774
Score = 60.1 bits (144), Expect = 8e-09
Identities = 39/175 (22%), Positives = 78/175 (44%), Gaps = 4/175 (2%)
Query: 577 ILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIV 636
+L +G Y+ Y +A +I+ E ++ + E + L + + ++ +
Sbjct: 507 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 566
Query: 637 SEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNL 696
+ E + +S Q HD A+ +A+Q+ P + L G++
Sbjct: 567 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLL----GHEFVLTEE 622
Query: 697 LDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLL 751
LDKA +R A+++NP AW +G I + + K+ A ++++AL + P S +L
Sbjct: 623 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 677
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/227 (23%), Positives = 103/227 (45%), Gaps = 10/227 (4%)
Query: 455 KKEEAITLL-KDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNN 513
+K+ A+++L KD +A+ + + + Q A + +Q I+ P+ + +
Sbjct: 553 QKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL 612
Query: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573
G V T +KA+A ++ AI+++P H+ A LG +Y + S+AE +++AL +
Sbjct: 613 LGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 672
Query: 574 KAEI-LSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTK----EA 628
++ + L +G + + + E+AL +A + P + A VL + K E
Sbjct: 673 QSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQEL 732
Query: 629 EKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPK 675
E++ + E Y L+ +Y K AL A+ L PK
Sbjct: 733 EELKQIVPKESL----VYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 775
Score = 44.3 bits (103), Expect = 4e-04
Identities = 47/244 (19%), Positives = 94/244 (38%), Gaps = 13/244 (5%)
Query: 539 PSHHV----AMVNLGRLYRSLGENSMAEEWYKRALQVA-HKAEILSPLGALYYNTGRYEE 593
PSHH + +GR Y L E AE + ++ ++ E + ++ +
Sbjct: 498 PSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVA 557
Query: 594 ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIY 653
+ ++ + + E A ++ + A K + + Y LL +
Sbjct: 558 LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 617
Query: 654 SKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPD 713
E DKAL A+++ P+ ++ G +Q A ++ A+ +NP
Sbjct: 618 VLTEELDKALACFRNAIRVNPRHYNA----WYGLGMIYYKQEKFSLAEMHFQKALDINPQ 673
Query: 714 QAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKL----DRLEKRLQEVR 769
+ ++G +QH K A +A+ + P + L K + A + ++ + LQE+
Sbjct: 674 SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELE 733
Query: 770 EKDQ 773
E Q
Sbjct: 734 ELKQ 737
Score = 38.9 bits (89), Expect = 0.018
Identities = 46/214 (21%), Positives = 89/214 (41%), Gaps = 12/214 (5%)
Query: 536 KLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV-AHKAEILSPLGALYYNTGRYEEA 594
K SP A N L R E+ +A ++++RA+QV + A + LG + T ++A
Sbjct: 570 KNSPEAWCAAGNCFSLQR---EHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 626
Query: 595 LQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHI--VSEETGCLECYRLLSAI 652
L ++ A + P L + + AE ++ ++ L C+ + +
Sbjct: 627 LACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH--IGVV 684
Query: 653 YSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712
+ +KALD ++KA+ + PK+P F + + L A + Q+ P
Sbjct: 685 QHALKKSEKALDTLNKAIVIDPKNPL----CKFHRASVLFANEKYKSALQELEELKQIVP 740
Query: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVP 746
++ + +G + G+ A + A+ L P
Sbjct: 741 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDP 774
Score = 32.0 bits (71), Expect = 2.2
Identities = 23/117 (19%), Positives = 55/117 (47%), Gaps = 3/117 (2%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TR 420
FR+ ++ P + Y Q + A H++ AL + P+ + L ++G + +
Sbjct: 630 FRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALK 689
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAY 477
+ +A +A+ + P++ F+ ++L + EK + A+ L++ + P+ + Y
Sbjct: 690 KSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVY 746
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 62.8 bits (151), Expect = 1e-09
Identities = 54/209 (25%), Positives = 92/209 (44%), Gaps = 15/209 (7%)
Query: 406 PRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKD 465
P A N +L R+ A ++QRA+Q+ P + A LG+ E+ ++A+ ++
Sbjct: 567 PEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRN 626
Query: 466 SIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPE 525
+I+ P +A+ L + +QE+F AE +Q + P SS L + GV E
Sbjct: 627 AIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSE 686
Query: 526 KAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSP----- 580
KA+ +AI + P + + + + A E YK ALQ + + + P
Sbjct: 687 KALDTLNKAIVIDPKNPLCKFHRASVL-------FANEKYKSALQELEELKQIVPKESLV 739
Query: 581 ---LGALYYNTGRYEEALQIYQEAAALQP 606
+G +Y G+ AL + A L P
Sbjct: 740 YFLIGKVYKKLGQTHLALMNFSWAMDLDP 768
Score = 60.1 bits (144), Expect = 8e-09
Identities = 39/175 (22%), Positives = 78/175 (44%), Gaps = 4/175 (2%)
Query: 577 ILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIV 636
+L +G Y+ Y +A +I+ E ++ + E + L + + ++ +
Sbjct: 501 VLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLT 560
Query: 637 SEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNL 696
+ E + +S Q HD A+ +A+Q+ P + L G++
Sbjct: 561 DMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLL----GHEFVLTEE 616
Query: 697 LDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLL 751
LDKA +R A+++NP AW +G I + + K+ A ++++AL + P S +L
Sbjct: 617 LDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 671
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/227 (23%), Positives = 103/227 (45%), Gaps = 10/227 (4%)
Query: 455 KKEEAITLL-KDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNN 513
+K+ A+++L KD +A+ + + + Q A + +Q I+ P+ + +
Sbjct: 547 QKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTL 606
Query: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573
G V T +KA+A ++ AI+++P H+ A LG +Y + S+AE +++AL +
Sbjct: 607 LGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP 666
Query: 574 KAEI-LSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTK----EA 628
++ + L +G + + + E+AL +A + P + A VL + K E
Sbjct: 667 QSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQEL 726
Query: 629 EKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPK 675
E++ + E Y L+ +Y K AL A+ L PK
Sbjct: 727 EELKQIVPKESL----VYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 769
Score = 44.3 bits (103), Expect = 4e-04
Identities = 47/244 (19%), Positives = 94/244 (38%), Gaps = 13/244 (5%)
Query: 539 PSHHV----AMVNLGRLYRSLGENSMAEEWYKRALQVA-HKAEILSPLGALYYNTGRYEE 593
PSHH + +GR Y L E AE + ++ ++ E + ++ +
Sbjct: 492 PSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVA 551
Query: 594 ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIY 653
+ ++ + + E A ++ + A K + + Y LL +
Sbjct: 552 LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 611
Query: 654 SKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPD 713
E DKAL A+++ P+ ++ G +Q A ++ A+ +NP
Sbjct: 612 VLTEELDKALACFRNAIRVNPRHYNA----WYGLGMIYYKQEKFSLAEMHFQKALDINPQ 667
Query: 714 QAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKL----DRLEKRLQEVR 769
+ ++G +QH K A +A+ + P + L K + A + ++ + LQE+
Sbjct: 668 SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELE 727
Query: 770 EKDQ 773
E Q
Sbjct: 728 ELKQ 731
Score = 38.9 bits (89), Expect = 0.018
Identities = 46/214 (21%), Positives = 89/214 (41%), Gaps = 12/214 (5%)
Query: 536 KLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV-AHKAEILSPLGALYYNTGRYEEA 594
K SP A N L R E+ +A ++++RA+QV + A + LG + T ++A
Sbjct: 564 KNSPEAWCAAGNCFSLQR---EHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKA 620
Query: 595 LQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHI--VSEETGCLECYRLLSAI 652
L ++ A + P L + + AE ++ ++ L C+ + +
Sbjct: 621 LACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH--IGVV 678
Query: 653 YSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712
+ +KALD ++KA+ + PK+P F + + L A + Q+ P
Sbjct: 679 QHALKKSEKALDTLNKAIVIDPKNPL----CKFHRASVLFANEKYKSALQELEELKQIVP 734
Query: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVP 746
++ + +G + G+ A + A+ L P
Sbjct: 735 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDP 768
Score = 32.0 bits (71), Expect = 2.2
Identities = 23/117 (19%), Positives = 55/117 (47%), Gaps = 3/117 (2%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TR 420
FR+ ++ P + Y Q + A H++ AL + P+ + L ++G + +
Sbjct: 624 FRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALK 683
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAY 477
+ +A +A+ + P++ F+ ++L + EK + A+ L++ + P+ + Y
Sbjct: 684 KSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVY 740
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 62.0 bits (149), Expect = 2e-09
Identities = 82/390 (21%), Positives = 157/390 (40%), Gaps = 53/390 (13%)
Query: 407 RHASALNNLGTLTRDTAEAKMYYQRALQL------HPQHNRALFNLGNLLKSQEKKEEAI 460
R + L + +D AK Y+++ L + RA NLG + + + + A+
Sbjct: 435 RAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTAL 494
Query: 461 TLLKDSIKYGPEFAD------AYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSD----- 509
L K + E +D AY ++ + + +A + ++ ++ + +D
Sbjct: 495 KLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQA 554
Query: 510 -LHNNYGVFLVDTGLPEKAVAHYQQAIKLS------PSHHVAMVNLGRLYRSLGENSMAE 562
H N V G ++A+ HYQ + ++ S A+ NLG + S GE A
Sbjct: 555 STHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAA 614
Query: 563 EWYKRALQVA-------HKAEILSPLGALYYNTGRYEEALQIYQEAAAL------QPSQR 609
+Y++ L++A + ++ LG +Y G Y+EA++ Y++ AL + SQ
Sbjct: 615 PYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQA 674
Query: 610 ELRLALAQVLAVMGQTKEAEKMTNHIVS------EETGCLECYRLLSAIYSKQENHDKAL 663
+ L + +AE+ +++S L I+ +++ + A+
Sbjct: 675 KAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAI 734
Query: 664 DAIDKALQL--KPKDPKVISELFFTKGNQLREQNLLDKA-------FESYRVAVQLNPDQ 714
++ L L + KD ++ + + G R DKA E Y+ L P +
Sbjct: 735 KFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDL-PGE 793
Query: 715 AQAWMNMGGIQHIKGKYVSARAYYERALQL 744
+A ++ + GKY A YE L L
Sbjct: 794 CRAHGHLAAVYMALGKYTMAFKCYEEQLDL 823
Score = 58.2 bits (139), Expect = 3e-08
Identities = 104/446 (23%), Positives = 166/446 (37%), Gaps = 79/446 (17%)
Query: 375 AKVHYNYANFLKDQGRNKEAIYHYRTALKL------YPRHASALNNLGTLTRDTAE---A 425
A H N A + G + A+ HY+ L + A AL+NLG E A
Sbjct: 554 ASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQA 613
Query: 426 KMYYQRALQLHPQ-----------HNR--ALFNLGNLLKSQEKKEEAITLLKDSIKYGPE 472
YY++ L+L P HN A + LGN ++ + E+ + L KD +
Sbjct: 614 APYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKD-LHDKLS 672
Query: 473 FADAYSSLASLLAEQERFKEAEEIYQ------TGIKNCPDSSDLHNNYGVFLVDTGLPEK 526
A AY +L F +AEE + + N N G +
Sbjct: 673 QAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDING 732
Query: 527 AVAHYQQAIKLSPSHHV--------AMVNLGRLYR-------SLGENSMAEEWYKRALQV 571
A+ Y+Q + L+ H V A LG YR +LG ++ E Y+ +
Sbjct: 733 AIKFYEQQLGLA--HQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDL 790
Query: 572 AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKM 631
+ L A+Y G+Y A + Y+E L ++ L AQV MG TK M
Sbjct: 791 PGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLE-AQVYGNMGITK----M 845
Query: 632 TNHIVSEETGCLE--------------------CYRLLSAIYSKQENHDKALDAIDKALQ 671
+++ E G E Y L Y ++++A+ ++ L
Sbjct: 846 NMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLS 905
Query: 672 LKPKDPKVISEL--FFTKGNQLREQNLLDKAFESYR----VAVQLNP--DQAQAWMNMGG 723
+ ++ + + GN R L +A + VA +L ++AQA+ +G
Sbjct: 906 VAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGS 965
Query: 724 IQHIKGKYVSARAYYERALQLVPDSK 749
+ G Y A + ER L + D K
Sbjct: 966 LHSQLGNYEQAISCLERQLNIARDMK 991
Score = 53.1 bits (126), Expect = 9e-07
Identities = 93/406 (22%), Positives = 157/406 (38%), Gaps = 88/406 (21%)
Query: 376 KVHYNYANFLKDQGRNKEAIYHYR----TALKLYPRHA--SALNNLG---TLTRDTAEAK 426
+ H N + +G +EA+ ++R A+KL R A SAL++LG T D A
Sbjct: 275 RAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNAL 334
Query: 427 MYYQRALQLHPQHN------RALFNLGNLLKSQEKKEEAITLLKDSIKYGPEF------A 474
+++ + L Q R L N+G + + E A+ + +K + A
Sbjct: 335 ASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEA 394
Query: 475 DAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQA 534
AYS+L S + F +A ++NY + L L EKA+
Sbjct: 395 RAYSNLGSAYHYRRNFDKAMS---------------YHNYVLELAQE-LMEKAIEMR--- 435
Query: 535 IKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH-------KAEILSPLGALYYN 587
A LG R + + A++++++ L +A + S LG ++
Sbjct: 436 ---------AYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486
Query: 588 TGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYR 647
G Y+ AL++++ + + A + MG A M + V L+
Sbjct: 487 KGDYDTALKLHKTHLCIAQELSDYA-AQGRAYGNMGNAYNALGMYDQAVKYHRQELQISM 545
Query: 648 LLSAIYSKQENHD------KALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAF 701
++ S+ H +AL A D+ALQ QN L+ A
Sbjct: 546 EVNDRASQASTHGNLAVAYQALGAHDRALQ--------------------HYQNHLNIAR 585
Query: 702 ESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPD 747
E + +A+A N+G +G+YV A YYE+ L+L PD
Sbjct: 586 ELRDIQ-----SEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPD 626
Score = 37.4 bits (85), Expect = 0.053
Identities = 69/330 (20%), Positives = 121/330 (36%), Gaps = 76/330 (23%)
Query: 411 ALNNLGTLTR---DTAEAKMYYQRALQLHPQHNR------ALFNLGNLLKSQEKKEEAIT 461
A NLG D EA YY++ L + NR A LGN ++ ++A+
Sbjct: 879 AYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALV 938
Query: 462 LLKDSIKYGPEF------ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYG 515
+ + E A AY L SL ++ +++A + + D D
Sbjct: 939 CFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKD------ 992
Query: 516 VFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKA 575
+A++ A LG +Y+ +GE A ++++ LQ+A +
Sbjct: 993 -----------------RALESD-----AACGLGGVYQQMGEYDTALQYHQLDLQIAEET 1030
Query: 576 EILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHI 635
+ G Y N G E+L ++ A Q Q L++ Q + T
Sbjct: 1031 NNPTCQGRAYGNLGLTYESLGTFERAVVYQ----------EQHLSIAAQMNDLAAKT--- 1077
Query: 636 VSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQL------KPKDPKVISEL---FFT 686
Y L + +N+ +A+ + + L+L + + K+ L +
Sbjct: 1078 --------VSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWA 1129
Query: 687 KGNQLREQNLLDKA---FESYRVAVQLNPD 713
GN Q+ L +A FE+ R QL+ D
Sbjct: 1130 SGNLEEAQHQLYRASALFETIRHEAQLSTD 1159
Score = 32.7 bits (73), Expect = 1.3
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 4/76 (5%)
Query: 646 YRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYR 705
Y SA Y K + +DKALD KA L PK PK +F +G L+ A ++
Sbjct: 95 YSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKA----YFRQGVALQYLGRHADALAAFA 150
Query: 706 VAVQLNPDQAQAWMNM 721
+ +P Q + M
Sbjct: 151 SGLAQDPKSLQLLVGM 166
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 62.0 bits (149), Expect = 2e-09
Identities = 80/384 (20%), Positives = 146/384 (38%), Gaps = 80/384 (20%)
Query: 449 LLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSS 508
LL QE K EA T E +AY + ++ + EA Y I CP ++
Sbjct: 18 LLDDQEAKREAETF--------KEQGNAYYA-------KKDYNEAYNYYTKAIDMCPKNA 62
Query: 509 DLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRA 568
+ N L+ G +A+ QQ+++L S + G+ + SLG A ++RA
Sbjct: 63 SYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRA 122
Query: 569 LQVAHK-----AEILSPLGALYY--------NTGRYEEALQIYQEAAALQPSQRELRLAL 615
L++ HK E + + Y + + + A P+ ++
Sbjct: 123 LELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILK 182
Query: 616 AQVLAVMGQTKEAEKMTNHIV--------------------------------------S 637
A+ LA++G+ EA+ + + I+
Sbjct: 183 AECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPD 242
Query: 638 EETGCLECYRLLSAIYSKQENHDKAL---------DAIDKALQLKPKDPKVISELFFTKG 688
E C+ C R A+ +K+E+ +KA + +AL + P + K ++L+ +G
Sbjct: 243 HEKACIAC-RNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRG 301
Query: 689 NQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDS 748
+ LD A E AV+L+ +A++ +Y A YE+ Q +
Sbjct: 302 TVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQ----T 357
Query: 749 KLLKENLAKLDRLEKRLQEVREKD 772
+ KE+ L + L++ + KD
Sbjct: 358 EKTKEHKQLLKNAQLELRKSKRKD 381
Score = 45.1 bits (105), Expect = 3e-04
Identities = 76/340 (22%), Positives = 134/340 (39%), Gaps = 51/340 (15%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKL-------YPRHASALNNLG 416
+ + P NA + N A L GR +EA+ + +++L + R +LG
Sbjct: 51 YTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLG 110
Query: 417 TLTRDTAEAKMYYQRALQLHPQHNRAL--FNLGNLLKSQEKKEEAITLLKDSIKY----- 469
+ A +QRAL+L ++ +A F N + EK E +D K
Sbjct: 111 ----NAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMD 166
Query: 470 -GPEFADAYSSL----ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLP 524
EFA A A LA R+ EA+ + ++ ++D G+ L
Sbjct: 167 RALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCI 226
Query: 525 EKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGAL 584
EKAV + QA++++P H A + A + A + G
Sbjct: 227 EKAVQFFVQALRMAPDHEKACI---------------------ACRNAKALKAKKEDGNK 265
Query: 585 YYNTGRYEEALQIYQEAAALQPSQRELRLAL----AQVLAVMGQTKEA-EKMTNHIVSEE 639
+ G Y+ A ++Y EA + P+ + L V + + + +A E TN + ++
Sbjct: 266 AFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDD 325
Query: 640 TGCLECYRLLSAIYSKQENHDKALDAIDKALQL-KPKDPK 678
T ++ Y + Y E +++A+ +K Q K K+ K
Sbjct: 326 T-YIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHK 364
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 62.0 bits (149), Expect = 2e-09
Identities = 61/286 (21%), Positives = 112/286 (39%), Gaps = 13/286 (4%)
Query: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGV 516
+E++ L + P+ AD +A L + K A E+Y K ++ +N GV
Sbjct: 84 QESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGV 143
Query: 517 FLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVA-HKA 575
+ KA A+ L+ H + + LG+++ G+ A E YK+A++ +
Sbjct: 144 CYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENT 202
Query: 576 EILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHI 635
E+L+ LG LY G Y++A + A P+ + LA ++ G A +
Sbjct: 203 ELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVV 262
Query: 636 VSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQN 695
+ + + ++ + A+ + +A L P D K++ L G
Sbjct: 263 ACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNL----GLVHLTMQ 318
Query: 696 LLDKAFESYRVAVQLNPDQAQAWM-------NMGGIQHIKGKYVSA 734
AF A+ P + +M N+ I++ K Y A
Sbjct: 319 QYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEA 364
Score = 60.8 bits (146), Expect = 5e-09
Identities = 64/262 (24%), Positives = 101/262 (38%), Gaps = 39/262 (14%)
Query: 491 KEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGR 550
+E+ E++QT P S+D L G + A+ Y +A KL+ NLG
Sbjct: 84 QESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGV 143
Query: 551 LYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRE 610
Y L + + A++ AL + LG ++ G ++A+++Y++A P E
Sbjct: 144 CYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTE 203
Query: 611 LRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKAL 670
L L + +G IY KA + + AL
Sbjct: 204 LLTTLGLLYLQLG----------------------------IY------QKAFEHLGNAL 229
Query: 671 QLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGK 730
P + K I G+ ++ D A YRV P+ W N+G K K
Sbjct: 230 TYDPTNYKAI----LAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKK 285
Query: 731 YVSARAYYERALQLVP-DSKLL 751
YV+A + +RA L P D K+L
Sbjct: 286 YVAAISCLKRANYLAPFDWKIL 307
Score = 53.5 bits (127), Expect = 7e-07
Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 5/259 (1%)
Query: 371 LPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQ 430
+ HN V Y Y LK + ++ + H L + L + L D +A Y+
Sbjct: 137 ISHNLGVCYIY---LKQFNKAQDQL-HNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYK 192
Query: 431 RALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERF 490
+A++ P++ L LG L ++A L +++ Y P A + S++ F
Sbjct: 193 KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDF 252
Query: 491 KEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGR 550
A Y+ P+S L NN G+ A++ ++A L+P + NLG
Sbjct: 253 DVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGL 312
Query: 551 LYRSLGENSMAEEWYKRALQVAHK-AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQR 609
++ ++ + + A + A+ K E+ L N E A + Y EA L
Sbjct: 313 VHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNP 372
Query: 610 ELRLALAQVLAVMGQTKEA 628
+ L A +L G+ K A
Sbjct: 373 LVNLNYAVLLYNQGEKKNA 391
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/168 (24%), Positives = 68/168 (40%), Gaps = 3/168 (1%)
Query: 372 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMY 428
P N K + ++ G A+ YR P NN+G + A
Sbjct: 233 PTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISC 292
Query: 429 YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQE 488
+RA L P + L+NLG + + ++ A L +I + P+ + Y LA L E
Sbjct: 293 LKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLE 352
Query: 489 RFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK 536
+ A+ Y + + ++ NY V L + G + A+A YQ+ K
Sbjct: 353 DIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEK 400
>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 61.2 bits (147), Expect = 3e-09
Identities = 60/245 (24%), Positives = 107/245 (43%), Gaps = 25/245 (10%)
Query: 388 QGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAE---AKMYYQRALQLHPQHNRALF 444
+G A+ + A++ P+H A LGT + + A +R L+L P + AL
Sbjct: 348 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 407
Query: 445 NLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSS----------------LASLLAEQE 488
L ++ + +A L+D ++Y P +A + L SLL++
Sbjct: 408 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSD-S 466
Query: 489 RFKEAEEIYQTGIKNCPDS--SDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546
F E +E++ ++ P S D+ GV +G +KAV + A+ + P+ ++
Sbjct: 467 LFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 526
Query: 547 NLGRLYRSLGENSMAEEWYKRALQVAHKAEILS--PLGALYYNTGRYEEALQIYQEAAAL 604
LG + ++ A Y+RAL++ I S LG N G + EA++ + EA +
Sbjct: 527 KLGATLANGNQSEEAVAAYRRALEL-QPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 585
Query: 605 QPSQR 609
Q R
Sbjct: 586 QRKSR 590
Score = 38.5 bits (88), Expect = 0.024
Identities = 48/221 (21%), Positives = 89/221 (40%), Gaps = 36/221 (16%)
Query: 527 AVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEI-LSPLGALY 585
AV ++ A++ P H A LG + +A +R L++ + L L +
Sbjct: 354 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 413
Query: 586 YNTGRYEEALQIYQE--------------------AAALQPSQRELRLALAQVLAVMGQT 625
N +A + ++ A L PS+R L L+ L + +
Sbjct: 414 TNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFL--EV 471
Query: 626 KE----AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVIS 681
KE A ++ + + C L +++ +DKA+D AL ++P D + +
Sbjct: 472 KELFLAAVRLDPTSIDPDVQCG-----LGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 526
Query: 682 ELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMG 722
+L G L N ++A +YR A++L P ++ N+G
Sbjct: 527 KL----GATLANGNQSEEAVAAYRRALELQPGYIRSRYNLG 563
Score = 34.7 bits (78), Expect = 0.35
Identities = 22/83 (26%), Positives = 39/83 (46%)
Query: 667 DKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQH 726
DK Q + ++P F +G + ++ L A + AVQ +P +AW +G Q
Sbjct: 321 DKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQA 380
Query: 727 IKGKYVSARAYYERALQLVPDSK 749
+ + A + R L+L PD++
Sbjct: 381 ENEQELLAISALRRCLELKPDNQ 403
>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 61.2 bits (147), Expect = 3e-09
Identities = 60/245 (24%), Positives = 107/245 (43%), Gaps = 25/245 (10%)
Query: 388 QGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAE---AKMYYQRALQLHPQHNRALF 444
+G A+ + A++ P+H A LGT + + A +R L+L P + AL
Sbjct: 348 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 407
Query: 445 NLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSS----------------LASLLAEQE 488
L ++ + +A L+D ++Y P +A + L SLL++
Sbjct: 408 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSD-S 466
Query: 489 RFKEAEEIYQTGIKNCPDS--SDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546
F E +E++ ++ P S D+ GV +G +KAV + A+ + P+ ++
Sbjct: 467 LFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 526
Query: 547 NLGRLYRSLGENSMAEEWYKRALQVAHKAEILS--PLGALYYNTGRYEEALQIYQEAAAL 604
LG + ++ A Y+RAL++ I S LG N G + EA++ + EA +
Sbjct: 527 KLGATLANGNQSEEAVAAYRRALEL-QPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 585
Query: 605 QPSQR 609
Q R
Sbjct: 586 QRKSR 590
Score = 38.5 bits (88), Expect = 0.024
Identities = 48/221 (21%), Positives = 89/221 (40%), Gaps = 36/221 (16%)
Query: 527 AVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEI-LSPLGALY 585
AV ++ A++ P H A LG + +A +R L++ + L L +
Sbjct: 354 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 413
Query: 586 YNTGRYEEALQIYQE--------------------AAALQPSQRELRLALAQVLAVMGQT 625
N +A + ++ A L PS+R L L+ L + +
Sbjct: 414 TNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFL--EV 471
Query: 626 KE----AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVIS 681
KE A ++ + + C L +++ +DKA+D AL ++P D + +
Sbjct: 472 KELFLAAVRLDPTSIDPDVQCG-----LGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 526
Query: 682 ELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMG 722
+L G L N ++A +YR A++L P ++ N+G
Sbjct: 527 KL----GATLANGNQSEEAVAAYRRALELQPGYIRSRYNLG 563
Score = 34.7 bits (78), Expect = 0.35
Identities = 22/83 (26%), Positives = 39/83 (46%)
Query: 667 DKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQH 726
DK Q + ++P F +G + ++ L A + AVQ +P +AW +G Q
Sbjct: 321 DKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQA 380
Query: 727 IKGKYVSARAYYERALQLVPDSK 749
+ + A + R L+L PD++
Sbjct: 381 ENEQELLAISALRRCLELKPDNQ 403
>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
sapiens]
Length = 602
Score = 61.2 bits (147), Expect = 3e-09
Identities = 60/245 (24%), Positives = 107/245 (43%), Gaps = 25/245 (10%)
Query: 388 QGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAE---AKMYYQRALQLHPQHNRALF 444
+G A+ + A++ P+H A LGT + + A +R L+L P + AL
Sbjct: 311 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 370
Query: 445 NLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSS----------------LASLLAEQE 488
L ++ + +A L+D ++Y P +A + L SLL++
Sbjct: 371 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSD-S 429
Query: 489 RFKEAEEIYQTGIKNCPDS--SDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546
F E +E++ ++ P S D+ GV +G +KAV + A+ + P+ ++
Sbjct: 430 LFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 489
Query: 547 NLGRLYRSLGENSMAEEWYKRALQVAHKAEILS--PLGALYYNTGRYEEALQIYQEAAAL 604
LG + ++ A Y+RAL++ I S LG N G + EA++ + EA +
Sbjct: 490 KLGATLANGNQSEEAVAAYRRALEL-QPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 548
Query: 605 QPSQR 609
Q R
Sbjct: 549 QRKSR 553
Score = 38.5 bits (88), Expect = 0.024
Identities = 48/221 (21%), Positives = 89/221 (40%), Gaps = 36/221 (16%)
Query: 527 AVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEI-LSPLGALY 585
AV ++ A++ P H A LG + +A +R L++ + L L +
Sbjct: 317 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 376
Query: 586 YNTGRYEEALQIYQE--------------------AAALQPSQRELRLALAQVLAVMGQT 625
N +A + ++ A L PS+R L L+ L + +
Sbjct: 377 TNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFL--EV 434
Query: 626 KE----AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVIS 681
KE A ++ + + C L +++ +DKA+D AL ++P D + +
Sbjct: 435 KELFLAAVRLDPTSIDPDVQCG-----LGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 489
Query: 682 ELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMG 722
+L G L N ++A +YR A++L P ++ N+G
Sbjct: 490 KL----GATLANGNQSEEAVAAYRRALELQPGYIRSRYNLG 526
Score = 34.7 bits (78), Expect = 0.35
Identities = 22/83 (26%), Positives = 39/83 (46%)
Query: 667 DKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQH 726
DK Q + ++P F +G + ++ L A + AVQ +P +AW +G Q
Sbjct: 284 DKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQA 343
Query: 727 IKGKYVSARAYYERALQLVPDSK 749
+ + A + R L+L PD++
Sbjct: 344 ENEQELLAISALRRCLELKPDNQ 366
>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
sapiens]
Length = 654
Score = 61.2 bits (147), Expect = 3e-09
Identities = 60/245 (24%), Positives = 107/245 (43%), Gaps = 25/245 (10%)
Query: 388 QGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAE---AKMYYQRALQLHPQHNRALF 444
+G A+ + A++ P+H A LGT + + A +R L+L P + AL
Sbjct: 363 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 422
Query: 445 NLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSS----------------LASLLAEQE 488
L ++ + +A L+D ++Y P +A + L SLL++
Sbjct: 423 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSD-S 481
Query: 489 RFKEAEEIYQTGIKNCPDS--SDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546
F E +E++ ++ P S D+ GV +G +KAV + A+ + P+ ++
Sbjct: 482 LFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 541
Query: 547 NLGRLYRSLGENSMAEEWYKRALQVAHKAEILS--PLGALYYNTGRYEEALQIYQEAAAL 604
LG + ++ A Y+RAL++ I S LG N G + EA++ + EA +
Sbjct: 542 KLGATLANGNQSEEAVAAYRRALEL-QPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 600
Query: 605 QPSQR 609
Q R
Sbjct: 601 QRKSR 605
Score = 38.5 bits (88), Expect = 0.024
Identities = 48/221 (21%), Positives = 89/221 (40%), Gaps = 36/221 (16%)
Query: 527 AVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEI-LSPLGALY 585
AV ++ A++ P H A LG + +A +R L++ + L L +
Sbjct: 369 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 428
Query: 586 YNTGRYEEALQIYQE--------------------AAALQPSQRELRLALAQVLAVMGQT 625
N +A + ++ A L PS+R L L+ L + +
Sbjct: 429 TNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFL--EV 486
Query: 626 KE----AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVIS 681
KE A ++ + + C L +++ +DKA+D AL ++P D + +
Sbjct: 487 KELFLAAVRLDPTSIDPDVQCG-----LGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 541
Query: 682 ELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMG 722
+L G L N ++A +YR A++L P ++ N+G
Sbjct: 542 KL----GATLANGNQSEEAVAAYRRALELQPGYIRSRYNLG 578
Score = 34.7 bits (78), Expect = 0.35
Identities = 22/83 (26%), Positives = 39/83 (46%)
Query: 667 DKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQH 726
DK Q + ++P F +G + ++ L A + AVQ +P +AW +G Q
Sbjct: 336 DKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQA 395
Query: 727 IKGKYVSARAYYERALQLVPDSK 749
+ + A + R L+L PD++
Sbjct: 396 ENEQELLAISALRRCLELKPDNQ 418
>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
sapiens]
Length = 631
Score = 61.2 bits (147), Expect = 3e-09
Identities = 60/245 (24%), Positives = 107/245 (43%), Gaps = 25/245 (10%)
Query: 388 QGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAE---AKMYYQRALQLHPQHNRALF 444
+G A+ + A++ P+H A LGT + + A +R L+L P + AL
Sbjct: 340 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 399
Query: 445 NLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSS----------------LASLLAEQE 488
L ++ + +A L+D ++Y P +A + L SLL++
Sbjct: 400 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSD-S 458
Query: 489 RFKEAEEIYQTGIKNCPDS--SDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546
F E +E++ ++ P S D+ GV +G +KAV + A+ + P+ ++
Sbjct: 459 LFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 518
Query: 547 NLGRLYRSLGENSMAEEWYKRALQVAHKAEILS--PLGALYYNTGRYEEALQIYQEAAAL 604
LG + ++ A Y+RAL++ I S LG N G + EA++ + EA +
Sbjct: 519 KLGATLANGNQSEEAVAAYRRALEL-QPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 577
Query: 605 QPSQR 609
Q R
Sbjct: 578 QRKSR 582
Score = 38.5 bits (88), Expect = 0.024
Identities = 48/221 (21%), Positives = 89/221 (40%), Gaps = 36/221 (16%)
Query: 527 AVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEI-LSPLGALY 585
AV ++ A++ P H A LG + +A +R L++ + L L +
Sbjct: 346 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 405
Query: 586 YNTGRYEEALQIYQE--------------------AAALQPSQRELRLALAQVLAVMGQT 625
N +A + ++ A L PS+R L L+ L + +
Sbjct: 406 TNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFL--EV 463
Query: 626 KE----AEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVIS 681
KE A ++ + + C L +++ +DKA+D AL ++P D + +
Sbjct: 464 KELFLAAVRLDPTSIDPDVQCG-----LGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWN 518
Query: 682 ELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMG 722
+L G L N ++A +YR A++L P ++ N+G
Sbjct: 519 KL----GATLANGNQSEEAVAAYRRALELQPGYIRSRYNLG 555
Score = 34.7 bits (78), Expect = 0.35
Identities = 22/83 (26%), Positives = 39/83 (46%)
Query: 667 DKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQH 726
DK Q + ++P F +G + ++ L A + AVQ +P +AW +G Q
Sbjct: 313 DKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQA 372
Query: 727 IKGKYVSARAYYERALQLVPDSK 749
+ + A + R L+L PD++
Sbjct: 373 ENEQELLAISALRRCLELKPDNQ 395
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 61.2 bits (147), Expect = 3e-09
Identities = 101/452 (22%), Positives = 179/452 (39%), Gaps = 72/452 (15%)
Query: 372 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMY 428
P +V A L GR EA+ A++L P A + GTL + D A A
Sbjct: 213 PDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHED 271
Query: 429 YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQE 488
+Q++L+L+ A+ G + +EAI K+++K +F DAY SL E
Sbjct: 272 FQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELG 331
Query: 489 RFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAM--- 545
F+ A E +Q + + G+ L G ++A+ ++++ ++L P + V
Sbjct: 332 NFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMK 391
Query: 546 ----VNLGRLYRSL-------------GENSMAE-------EWYKRALQVAHKAEILSPL 581
V +G+ Y + G+ + E Y R L AH L+
Sbjct: 392 GLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLH-AHLDTPLTEY 450
Query: 582 GALYYNTGRYEE--------ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTN 633
G +++ ++ Y+E LQP + VL ++ + E
Sbjct: 451 NIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPH-------IKDVLHQNFESYKPEVQEL 503
Query: 634 HIVSEETGCLECYRLLSAIYSKQENHDKALDAID--KALQLKPKDPKVISELFFTKGNQL 691
V++ G L Y + +K+ + L A++ +A+Q + KV K +
Sbjct: 504 ICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMN---GKTRLM 560
Query: 692 REQNLLDKAFESYRVAVQLNPDQAQAWMNM-----------GGIQHIKGKYVSAR--AYY 738
+ +++ D A + R+A +PDQ W++ I I+G+ ++ R Y+
Sbjct: 561 QWRDMFDIAVKWRRIA---DPDQPVLWLDQMPARSLSRGFNNHINLIRGQVINMRYLEYF 617
Query: 739 ERALQLVPDSKLLKENLAKLDRLEKRLQEVRE 770
E+ L + D L+ K L EVRE
Sbjct: 618 EKILHFIKDRILVYHGANN----PKGLLEVRE 645
Score = 60.1 bits (144), Expect = 8e-09
Identities = 61/264 (23%), Positives = 104/264 (39%), Gaps = 10/264 (3%)
Query: 382 ANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL--------TRDTAEAKMYYQRAL 433
A L G EAI H+ T L+ P SA+ G ++ A R +
Sbjct: 150 AYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVI 209
Query: 434 QLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEA 493
L P +L + EA+ L +I+ P A Y +L E + A
Sbjct: 210 TLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATA 268
Query: 494 EEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYR 553
E +Q ++ + G+ GL ++A+ +++A+K A +LG+ YR
Sbjct: 269 HEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYR 328
Query: 554 SLGENSMAEEWYKRALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR 612
LG A E +++AL + + + L G + Y+ G +EAL+ ++ L+P +
Sbjct: 329 ELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQ 388
Query: 613 LALAQVLAVMGQTKEAEKMTNHIV 636
MGQ E K ++
Sbjct: 389 YMKGLSHVAMGQFYEGIKAQTKVM 412
Score = 55.8 bits (133), Expect = 1e-07
Identities = 58/268 (21%), Positives = 103/268 (38%), Gaps = 15/268 (5%)
Query: 465 DSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGL- 523
D+ E A AY + S L + EA + T ++ PD G+ GL
Sbjct: 139 DNDSTNEELAIAYVLIGSGL-----YDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLH 193
Query: 524 ----PEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILS 579
E A+ + I L P + LG + A +A+Q+ A +
Sbjct: 194 DIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYR 253
Query: 580 PLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEE 639
G LY+ + Y A + +Q++ L +Q L G KEA + + ++
Sbjct: 254 HRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQK 313
Query: 640 TGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDK 699
++ Y+ L Y + N + A ++ KAL L + + +G L L +
Sbjct: 314 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQ----LRGMMLYHHGSLQE 369
Query: 700 AFESYRVAVQLNPDQAQAWMNMGGIQHI 727
A ++++ +QL P + M G+ H+
Sbjct: 370 ALKNFKRCLQLEP-YNEVCQYMKGLSHV 396
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 60.1 bits (144), Expect = 8e-09
Identities = 67/305 (21%), Positives = 119/305 (39%), Gaps = 41/305 (13%)
Query: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAE---QERFKEAEEIYQTGIKNCPDSSDLHNN 513
EEA+ ++K P F DAY + E E K+A++ + + P +
Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
Query: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573
+G L G +KA H+ AI P +++A + +G N A + A++++
Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440
Query: 574 KAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTN 633
AE L+ G ++ G + A++ YQ+A L P + +LA
Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP-----KYSLA----------------- 1478
Query: 634 HIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLRE 693
Y IY +A D KAL+ P++ V+ T N + +
Sbjct: 1479 ------------YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT--NTILK 1524
Query: 694 QNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKE 753
+ ++A E + ++ P A + N + +Y A +AL L P+ L+
Sbjct: 1525 K--YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582
Query: 754 NLAKL 758
AK+
Sbjct: 1583 FRAKV 1587
Score = 53.9 bits (128), Expect = 6e-07
Identities = 55/283 (19%), Positives = 109/283 (38%), Gaps = 42/283 (14%)
Query: 488 ERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVN 547
E FK+A I +T C ++ H+ F E+AV + A+K++P A V
Sbjct: 1291 EDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFTWALKINPCFLDAYVG 1343
Query: 548 LGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607
G Y G + ++ K L+ H + P+
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALH------------------------------INPA 1373
Query: 608 QRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAID 667
+ R++ L G+ ++A + + Y + + + N+ A+ I+
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 668 KALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHI 727
A+++ +E +G A + Y+ A+ LNP + A+ N G I
Sbjct: 1434 AAMKIS-----TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFH 1488
Query: 728 KGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVRE 770
++ A Y+ +AL+ P+++ + N A + + K+ +E +E
Sbjct: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 8/220 (3%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR--- 420
F + T P N + A G N A+ A+K+ A L N G +
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMG 1456
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
A YQ A+ L+P+++ A FN GN+ + +A ++K+ PE +
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNR 1516
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
A ++++EA+E + I++CP + ++ N F E A +A+ L P+
Sbjct: 1517 AITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPN 1576
Query: 541 HHVAMVNLGRLYRSLG--ENSMAEEWYKRALQVAHKAEIL 578
+ ++ +G E +MA+ Y +AL + A ++
Sbjct: 1577 DALVYNFRAKVRGKIGLIEEAMAD--YNQALDLEDYASVI 1614
Score = 38.1 bits (87), Expect = 0.031
Identities = 61/264 (23%), Positives = 92/264 (34%), Gaps = 42/264 (15%)
Query: 405 YPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 464
Y R + LG L A QR + L P A ++ + Q+K EA+ L
Sbjct: 920 YCRRGAIYRKLGKLQ----SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLN 975
Query: 465 DSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLP 524
KY +AY S A + ++ A Y IK+ P +D++ G T
Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN-K 1034
Query: 525 EKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGAL 584
A+ + + I P A++ G Y EN E W+
Sbjct: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFY---CEN---ENWF------------------- 1069
Query: 585 YYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLE 644
++ AL + A Q L +M A+ I + G E
Sbjct: 1070 -----------AAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSE 1118
Query: 645 CYRLLSA-IYSKQENHDKALDAID 667
+ A IYS ENHDKA++ +D
Sbjct: 1119 LSPMQQALIYSFCENHDKAIEVLD 1142
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 60.1 bits (144), Expect = 8e-09
Identities = 67/305 (21%), Positives = 119/305 (39%), Gaps = 41/305 (13%)
Query: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAE---QERFKEAEEIYQTGIKNCPDSSDLHNN 513
EEA+ ++K P F DAY + E E K+A++ + + P +
Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
Query: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573
+G L G +KA H+ AI P +++A + +G N A + A++++
Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440
Query: 574 KAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTN 633
AE L+ G ++ G + A++ YQ+A L P + +LA
Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP-----KYSLA----------------- 1478
Query: 634 HIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLRE 693
Y IY +A D KAL+ P++ V+ T N + +
Sbjct: 1479 ------------YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT--NTILK 1524
Query: 694 QNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKE 753
+ ++A E + ++ P A + N + +Y A +AL L P+ L+
Sbjct: 1525 K--YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582
Query: 754 NLAKL 758
AK+
Sbjct: 1583 FRAKV 1587
Score = 53.9 bits (128), Expect = 6e-07
Identities = 55/283 (19%), Positives = 109/283 (38%), Gaps = 42/283 (14%)
Query: 488 ERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVN 547
E FK+A I +T C ++ H+ F E+AV + A+K++P A V
Sbjct: 1291 EDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFTWALKINPCFLDAYVG 1343
Query: 548 LGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607
G Y G + ++ K L+ H + P+
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALH------------------------------INPA 1373
Query: 608 QRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAID 667
+ R++ L G+ ++A + + Y + + + N+ A+ I+
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 668 KALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHI 727
A+++ +E +G A + Y+ A+ LNP + A+ N G I
Sbjct: 1434 AAMKIS-----TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFH 1488
Query: 728 KGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVRE 770
++ A Y+ +AL+ P+++ + N A + + K+ +E +E
Sbjct: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 8/220 (3%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR--- 420
F + T P N + A G N A+ A+K+ A L N G +
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMG 1456
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
A YQ A+ L+P+++ A FN GN+ + +A ++K+ PE +
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNR 1516
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
A ++++EA+E + I++CP + ++ N F E A +A+ L P+
Sbjct: 1517 AITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPN 1576
Query: 541 HHVAMVNLGRLYRSLG--ENSMAEEWYKRALQVAHKAEIL 578
+ ++ +G E +MA+ Y +AL + A ++
Sbjct: 1577 DALVYNFRAKVRGKIGLIEEAMAD--YNQALDLEDYASVI 1614
Score = 38.1 bits (87), Expect = 0.031
Identities = 61/264 (23%), Positives = 92/264 (34%), Gaps = 42/264 (15%)
Query: 405 YPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 464
Y R + LG L A QR + L P A ++ + Q+K EA+ L
Sbjct: 920 YCRRGAIYRKLGKLQ----SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLN 975
Query: 465 DSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLP 524
KY +AY S A + ++ A Y IK+ P +D++ G T
Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN-K 1034
Query: 525 EKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGAL 584
A+ + + I P A++ G Y EN E W+
Sbjct: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFY---CEN---ENWF------------------- 1069
Query: 585 YYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLE 644
++ AL + A Q L +M A+ I + G E
Sbjct: 1070 -----------AAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSE 1118
Query: 645 CYRLLSA-IYSKQENHDKALDAID 667
+ A IYS ENHDKA++ +D
Sbjct: 1119 LSPMQQALIYSFCENHDKAIEVLD 1142
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 60.1 bits (144), Expect = 8e-09
Identities = 67/305 (21%), Positives = 119/305 (39%), Gaps = 41/305 (13%)
Query: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAE---QERFKEAEEIYQTGIKNCPDSSDLHNN 513
EEA+ ++K P F DAY + E E K+A++ + + P +
Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
Query: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573
+G L G +KA H+ AI P +++A + +G N A + A++++
Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440
Query: 574 KAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTN 633
AE L+ G ++ G + A++ YQ+A L P + +LA
Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP-----KYSLA----------------- 1478
Query: 634 HIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLRE 693
Y IY +A D KAL+ P++ V+ T N + +
Sbjct: 1479 ------------YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT--NTILK 1524
Query: 694 QNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKE 753
+ ++A E + ++ P A + N + +Y A +AL L P+ L+
Sbjct: 1525 K--YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582
Query: 754 NLAKL 758
AK+
Sbjct: 1583 FRAKV 1587
Score = 53.9 bits (128), Expect = 6e-07
Identities = 55/283 (19%), Positives = 109/283 (38%), Gaps = 42/283 (14%)
Query: 488 ERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVN 547
E FK+A I +T C ++ H+ F E+AV + A+K++P A V
Sbjct: 1291 EDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFTWALKINPCFLDAYVG 1343
Query: 548 LGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607
G Y G + ++ K L+ H + P+
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALH------------------------------INPA 1373
Query: 608 QRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAID 667
+ R++ L G+ ++A + + Y + + + N+ A+ I+
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 668 KALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHI 727
A+++ +E +G A + Y+ A+ LNP + A+ N G I
Sbjct: 1434 AAMKIS-----TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFH 1488
Query: 728 KGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVRE 770
++ A Y+ +AL+ P+++ + N A + + K+ +E +E
Sbjct: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 8/220 (3%)
Query: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR--- 420
F + T P N + A G N A+ A+K+ A L N G +
Sbjct: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMG 1456
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
A YQ A+ L+P+++ A FN GN+ + +A ++K+ PE +
Sbjct: 1457 HKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNR 1516
Query: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
A ++++EA+E + I++CP + ++ N F E A +A+ L P+
Sbjct: 1517 AITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPN 1576
Query: 541 HHVAMVNLGRLYRSLG--ENSMAEEWYKRALQVAHKAEIL 578
+ ++ +G E +MA+ Y +AL + A ++
Sbjct: 1577 DALVYNFRAKVRGKIGLIEEAMAD--YNQALDLEDYASVI 1614
Score = 38.1 bits (87), Expect = 0.031
Identities = 61/264 (23%), Positives = 92/264 (34%), Gaps = 42/264 (15%)
Query: 405 YPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 464
Y R + LG L A QR + L P A ++ + Q+K EA+ L
Sbjct: 920 YCRRGAIYRKLGKLQ----SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLN 975
Query: 465 DSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLP 524
KY +AY S A + ++ A Y IK+ P +D++ G T
Sbjct: 976 YIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN-K 1034
Query: 525 EKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGAL 584
A+ + + I P A++ G Y EN E W+
Sbjct: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFY---CEN---ENWF------------------- 1069
Query: 585 YYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLE 644
++ AL + A Q L +M A+ I + G E
Sbjct: 1070 -----------AAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSE 1118
Query: 645 CYRLLSA-IYSKQENHDKALDAID 667
+ A IYS ENHDKA++ +D
Sbjct: 1119 LSPMQQALIYSFCENHDKAIEVLD 1142
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 59.3 bits (142), Expect = 1e-08
Identities = 56/250 (22%), Positives = 108/250 (43%), Gaps = 30/250 (12%)
Query: 479 SLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK-L 537
S A +AEQ+RF A + DS++ L+ +GL ++A+ H+ ++ L
Sbjct: 123 SQAKSIAEQKRFPFATD---------NDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQIL 173
Query: 538 SPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQI 597
SP LGR+ ++ + + +A+Q+ A + G LY+ + Y A +
Sbjct: 174 SP--------LGRINEAVNDLT-------KAIQLQPSARLYRHRGTLYFISEDYATAHED 218
Query: 598 YQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQE 657
+Q++ L +Q L G KEA + + ++ ++ Y+ L Y +
Sbjct: 219 FQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELG 278
Query: 658 NHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQA 717
N + A ++ KAL L + + +G L L +A ++++ +QL P +
Sbjct: 279 NFEAATESFQKALLLNQNHVQTLQ----LRGMMLYHHGSLQEALKNFKRCLQLEP-YNEV 333
Query: 718 WMNMGGIQHI 727
M G+ H+
Sbjct: 334 CQYMKGLSHV 343
Score = 57.8 bits (138), Expect = 4e-08
Identities = 98/439 (22%), Positives = 175/439 (39%), Gaps = 72/439 (16%)
Query: 385 LKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNR 441
L GR EA+ A++L P A + GTL + D A A +Q++L+L+
Sbjct: 173 LSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPI 231
Query: 442 ALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGI 501
A+ G + +EAI K+++K +F DAY SL E F+ A E +Q +
Sbjct: 232 AMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKAL 291
Query: 502 KNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAM-------VNLGRLYRS 554
+ G+ L G ++A+ ++++ ++L P + V V +G+ Y
Sbjct: 292 LLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEG 351
Query: 555 L-------------GENSMAE-------EWYKRALQVAHKAEILSPLGALYYNTGRYEE- 593
+ G+ + E Y R L AH L+ G +++
Sbjct: 352 IKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLH-AHLDTPLTEYNIDVDLPGSFKDH 410
Query: 594 -------ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECY 646
++ Y+E LQP + VL ++ + E V++ G L Y
Sbjct: 411 WAKNLPFLIEDYEEQPGLQPH-------IKDVLHQNFESYKPEVQELICVADRLGSLMQY 463
Query: 647 RLLSAIYSKQENHDKALDAID--KALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESY 704
+ +K+ + L A++ +A+Q + KV K ++ +++ D A +
Sbjct: 464 ETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMN---GKTRLMQWRDMFDIAVKWR 520
Query: 705 RVAVQLNPDQAQAWMNM-----------GGIQHIKGKYVSAR--AYYERALQLVPDSKLL 751
R+A +PDQ W++ I I+G+ ++ R Y+E+ L + D L+
Sbjct: 521 RIA---DPDQPVLWLDQMPARSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILV 577
Query: 752 KENLAKLDRLEKRLQEVRE 770
K L EVRE
Sbjct: 578 YHGANN----PKGLLEVRE 592
Score = 50.1 bits (118), Expect = 8e-06
Identities = 46/203 (22%), Positives = 86/203 (42%), Gaps = 2/203 (0%)
Query: 435 LHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAE 494
L+ + R + +L + EA+ L +I+ P A Y +L E + A
Sbjct: 158 LYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAH 216
Query: 495 EIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRS 554
E +Q ++ + G+ GL ++A+ +++A+K A +LG+ YR
Sbjct: 217 EDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRE 276
Query: 555 LGENSMAEEWYKRALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRL 613
LG A E +++AL + + + L G + Y+ G +EAL+ ++ L+P +
Sbjct: 277 LGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336
Query: 614 ALAQVLAVMGQTKEAEKMTNHIV 636
MGQ E K ++
Sbjct: 337 MKGLSHVAMGQFYEGIKAQTKVM 359
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 57.8 bits (138), Expect = 4e-08
Identities = 77/360 (21%), Positives = 147/360 (40%), Gaps = 43/360 (11%)
Query: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLL---KSQEKKEEAITLLKDSIKYGPEFADAY 477
D A +++ L+ +P + + LG+L + QEK++ A LK + P+ +A+
Sbjct: 356 DKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAW 415
Query: 478 SSLASLLAEQERFKEAEEIYQTGIKNCPDS------SDLHNNYGVFLVDTG-LPE----- 525
LA +L EQ + A Y T + + ++ NN G G L E
Sbjct: 416 IELAQIL-EQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYF 474
Query: 526 -------KAVA----HYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV-AH 573
KA A HY AI ++ S+ NL RLY ++ E AE+ YK L+ +
Sbjct: 475 LASLDRAKAEAEHDEHYYNAISVTTSY-----NLARLYEAMCEFHEAEKLYKNILREHPN 529
Query: 574 KAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTN 633
+ LGA+ + G + EA ++EA + + + + + +K
Sbjct: 530 YVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFE 589
Query: 634 HIVSEETGCLECYRLLS-------AIYSKQENHDKALDAIDKALQLKPKDPKVISELFFT 686
I+ + + + Y +L+ ++ + +K D+AL + + + ++ +
Sbjct: 590 RILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYA 649
Query: 687 K---GNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQ 743
G L + +A + + + D + W+N+ I + +Y+SA YE L+
Sbjct: 650 ANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLR 709
Score = 47.8 bits (112), Expect = 4e-05
Identities = 81/337 (24%), Positives = 131/337 (38%), Gaps = 47/337 (13%)
Query: 365 RSGVQTL-------PHNAKVHYNYAN---FLKDQGRNKEAIYHYRTALKLYPRHASALNN 414
++GVQ L P N V + AN F KD + + H ++ A +
Sbjct: 252 KNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQ 311
Query: 415 LGT---LTRDTAEAKMYYQRALQL-HPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYG 470
L + D +A YY +A Q F LG + + KE A + +K
Sbjct: 312 LARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAY 371
Query: 471 PEFADAYSSLASLLAEQERFKEAEEIYQTGIKNC----PDSSDLHNNYGVFLVDTGLPEK 526
P + L SL A E +E +I + +K PD + L T + +
Sbjct: 372 PNNYETMKILGSLYAASED-QEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDI-QG 429
Query: 527 AVAHYQQAIKLSPSHHVAMV------NLGRLYRSLGENSMAEEWYKRALQVAHKAEILSP 580
A++ Y A ++ A V N+G L+ LG A++++ +L A KAE
Sbjct: 430 ALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRA-KAEA--- 485
Query: 581 LGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEET 640
E + Y A ++ S LA++ M + EAEK+ +I+ E
Sbjct: 486 ------------EHDEHYYNAISVTTSYN-----LARLYEAMCEFHEAEKLYKNILREHP 528
Query: 641 GCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDP 677
++CY L A+ + N +A D +ALQ+ P
Sbjct: 529 NYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHP 565
Score = 46.6 bits (109), Expect = 9e-05
Identities = 59/281 (20%), Positives = 118/281 (41%), Gaps = 21/281 (7%)
Query: 411 ALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYG 470
AL+ GT TR E K+ ++ F LGNL ++++ ++ K ++
Sbjct: 430 ALSAYGTATRILQE-KVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHD 488
Query: 471 PEFADAYS-----SLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPE 525
+ +A S +LA L F EAE++Y+ ++ P+ D + G D G
Sbjct: 489 EHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFY 548
Query: 526 KAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRAL-QVAHKAEILS--PLG 582
+A +++A++++ H A +G L+ + E ++ ++R L Q + +++ S LG
Sbjct: 549 EASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALG 608
Query: 583 ALYYNT------------GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEK 630
++ T + AL IY++ + VLA G +EA
Sbjct: 609 NVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARD 668
Query: 631 MTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQ 671
+ + + + L+ IY +Q+ + A+ + L+
Sbjct: 669 VFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLR 709
Score = 42.7 bits (99), Expect = 0.001
Identities = 38/173 (21%), Positives = 72/173 (41%), Gaps = 11/173 (6%)
Query: 586 YNTGRYEEALQIYQEAAALQPS-QRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLE 644
+N Y AL Y++A P E+RL + + + ++A + + + C+
Sbjct: 174 FNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVG 233
Query: 645 CYRLLSAIYSKQENHDK---ALDAIDKALQLKPKDPKVISEL---FFTKGNQLREQNLLD 698
L+ + + D + + +A + P +P V++ L FF K + + Q+L
Sbjct: 234 ALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLAL 293
Query: 699 KAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLL 751
AF + V QA++ + H++ Y A YY +A Q S +L
Sbjct: 294 HAFHNTEVEAM----QAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVL 342
Score = 39.7 bits (91), Expect = 0.011
Identities = 45/232 (19%), Positives = 98/232 (42%), Gaps = 18/232 (7%)
Query: 361 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL-- 418
E L+++ ++ P+ + +D+G EA ++ AL++ H A + +G L
Sbjct: 517 EKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHL 576
Query: 419 -TRDTAEAKMYYQRALQLHPQHNR--ALFNLGNLL------------KSQEKKEEAITLL 463
++ + ++R L+ + ++ LGN+ K + ++ A+ +
Sbjct: 577 AKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIY 636
Query: 464 KDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGL 523
K ++ + A + + ++LA + F+EA +++ + D SD+ N V+
Sbjct: 637 KQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQ 696
Query: 524 PEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKA 575
AV Y+ ++ H V L L R+L + +E + L+ H A
Sbjct: 697 YISAVQMYENCLRKFYKHQNTEVVL-YLARALFKCGKLQECKQTLLKARHVA 747
Score = 37.4 bits (85), Expect = 0.053
Identities = 44/178 (24%), Positives = 71/178 (39%), Gaps = 21/178 (11%)
Query: 607 SQRELRLALAQVLAVMGQTKEAEKMTN--------HIVSEETGCLECYRLLSAIY----S 654
+Q + +ALA G+T+E K+ E + C L+A Y
Sbjct: 39 TQLHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQAR 98
Query: 655 KQENHDKALDAIDKALQLKPKDPKVI----SELFFTKGNQLREQNLLDKAFESYRVAVQL 710
K++N D D I +A L K+I + L L E + +D+A + +
Sbjct: 99 KEKNKDNKKDLITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFHFVLNQ 158
Query: 711 NPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKL-----LKENLAKLDRLEK 763
+P+ A + I K Y A AYY++AL+ P + KL++LEK
Sbjct: 159 SPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEK 216
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 57.4 bits (137), Expect = 5e-08
Identities = 92/427 (21%), Positives = 160/427 (37%), Gaps = 48/427 (11%)
Query: 367 GVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAK 426
G++ P Y+ A R KEA+ ALK+ ++NLG A
Sbjct: 298 GLKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKI-------VDNLG------ASGN 344
Query: 427 MYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAE 486
YQR L LH + + L + EEAI L D I +
Sbjct: 345 SLYQRNLCLHLKAEALI-----KLSDYDSSEEAIRTL-DQISDADNIPGLLVLKSLAYRN 398
Query: 487 QERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMV 546
+ F EA +I + + + PD +++H + +A +Q+A++
Sbjct: 399 KGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHY 458
Query: 547 NLGRLYRSLGENSMAEE------WYKRALQVAHKAEILSPLGALYYNT-GRYEEALQIYQ 599
LG Y +GE + ++ + K A + ++ LG Y + G A Y+
Sbjct: 459 QLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYR 518
Query: 600 EAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLL--SAIYSKQE 657
+A L + E A + + + A + + + + + L Y K
Sbjct: 519 KAFELDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAG 578
Query: 658 NHDKALDAIDKALQLKPKDPKV---ISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQ 714
H +A+ + AL+ PKD + E + ++G A +S+ A +LNP+
Sbjct: 579 QHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTT-------ALKSFTKASELNPES 631
Query: 715 AQAWMNMGGIQHIKGKYVSARAYYER----------ALQLVPDSKLLKENLAKLDRLEKR 764
+ + IQ I GKY A A Y+ AL+ + + L+ A +D L+ +
Sbjct: 632 IYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGK 691
Query: 765 LQEVREK 771
+ EK
Sbjct: 692 AVDYIEK 698
Score = 53.9 bits (128), Expect = 6e-07
Identities = 63/240 (26%), Positives = 100/240 (41%), Gaps = 20/240 (8%)
Query: 459 AITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIK--NCPDSSDLHN---- 512
A +L ++ +A A++ L L + KEA YQ I + D +N
Sbjct: 965 AQVILNKYVERIQNYAPAFTMLGYLNEHLQLKKEAANAYQRAILLLQTAEDQDTYNVAIR 1024
Query: 513 NYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVA-MVNLGRLYRSLGENSMAEEWYKRALQV 571
NYG L TG +KA+ QA K +P + ++ G + + Y+RAL +
Sbjct: 1025 NYGRLLCSTGEYDKAI----QAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYERALSI 1080
Query: 572 AH----KAEILSPLGALYYNTGRYEEALQIYQEAAAL-QPSQRELRLALAQVLAVMGQTK 626
KA IL+ L Y G+ + A + + + L +P+ L+ A LA+ T
Sbjct: 1081 VESEQDKAHILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQDATL 1140
Query: 627 EA---EKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISEL 683
++ HI +++ C L SAIY+ Q I KA+ P DP + S L
Sbjct: 1141 SKAALNELLKHIKHKDSNYQRCL-LTSAIYALQGRSVAVQKQISKAVHSNPGDPALWSLL 1199
Score = 43.1 bits (100), Expect = 0.001
Identities = 63/304 (20%), Positives = 115/304 (37%), Gaps = 35/304 (11%)
Query: 422 TAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLA 481
T E + Y R +++ + L LG +K E+A+ L + +K P + LA
Sbjct: 254 TDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAVRNLTEGLKESPVCTSGWYHLA 313
Query: 482 SLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSH 541
+ R KEA + +C + + +N G + YQ+ + L
Sbjct: 314 EAQVKMHRPKEA-------VLSCSQALKIVDNLGA---------SGNSLYQRNLCLHLKA 357
Query: 542 HVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPL---GALYYNTGRYEEALQIY 598
+ L + +EE + Q++ I L Y N G ++EA +I
Sbjct: 358 EALI--------KLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIM 409
Query: 599 QEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIY----- 653
++ + P E+ A + +AEK + ++T E + L Y
Sbjct: 410 EDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGE 469
Query: 654 SKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPD 713
+++ KAL KA +L KV L + + ++N +A YR A +L+
Sbjct: 470 ETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKN---RARGCYRKAFELDDT 526
Query: 714 QAQA 717
A++
Sbjct: 527 DAES 530
Score = 37.0 bits (84), Expect = 0.070
Identities = 59/235 (25%), Positives = 91/235 (38%), Gaps = 25/235 (10%)
Query: 542 HVAMVNLGR---LYRSLGE----NSMAEEWYKRALQVAHKAEILSP----LGALYYNTGR 590
H+ N G+ LY ++ + +S AE+ AL+ KA +LSP + A
Sbjct: 1222 HILDSNHGKKALLYTAVNQLAMGSSSAEDEKNTALKTIQKAALLSPGDPAIWAGLMAACH 1281
Query: 591 YEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLS 650
++ L + QP + +L LAL AV K+ + N+ S LE + L
Sbjct: 1282 ADDKLALVNNT---QPKRIDLYLALLS--AVSASIKDEKFFENYNQS-----LEKWSLSQ 1331
Query: 651 AIYSKQENH--DKALDAIDKALQLKPKDPKVISELFFTKGNQLREQN--LLDKAFESYRV 706
A+ + +A K L+ P P VI L + L E L D E +
Sbjct: 1332 AVTGLIDTGRISEAETLCTKNLKSNPDQPAVILLLRQVQCKPLLESQKPLPDAVLEELQK 1391
Query: 707 AVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRL 761
V N AW + + +G +A Y ++LQL L+ L RL
Sbjct: 1392 TVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQRGSWSGKLSSLLRL 1446
Score = 34.3 bits (77), Expect = 0.45
Identities = 72/365 (19%), Positives = 142/365 (38%), Gaps = 53/365 (14%)
Query: 389 GRNKEAIYHYRTALKLYPRHASALNNLGT--LTRDT-AEAKMYYQRALQLHPQHNRALFN 445
G++ +A+ + AL+ P+ + +LG L+R A + +A +L+P+ ++F
Sbjct: 578 GQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFK 637
Query: 446 LGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLAS---LLAEQ-----------ERFK 491
+ + + K +EA+ + IK ++ A L ++A+ + +
Sbjct: 638 VAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIE 697
Query: 492 EAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRL 551
+A E + +++ D S L G D AVA + + HV V LG+
Sbjct: 698 KALEYFTCALQHRADVSCLWKLAG----DACTCLYAVAPSKVNV------HVLGVLLGQK 747
Query: 552 Y--RSLGENSMAE---EWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQP 606
+ L +N + Y RAL++ + LG YY Q A
Sbjct: 748 EGKQVLKKNELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQA---------QHLAETGS 798
Query: 607 SQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAI 666
+ +L+ L + L + + + NH+ G + CY + Q K++
Sbjct: 799 NMNDLKELLEKSLHCLKKAVRLDS-NNHLYWNALGVVACYSGIGNYALAQHCFIKSI--- 854
Query: 667 DKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQH 726
++ Q+ + L+ T N +++A E++++A L+P W+ I
Sbjct: 855 -QSEQINAVAWTNLGVLYLTNEN-------IEQAHEAFKMAQSLDPSYLMCWIGQALIAE 906
Query: 727 IKGKY 731
G Y
Sbjct: 907 AVGSY 911
Score = 31.6 bits (70), Expect = 2.9
Identities = 96/474 (20%), Positives = 183/474 (38%), Gaps = 87/474 (18%)
Query: 357 WLSRESLFRSGVQTLPHNAKVHYNYAN---FLKDQGRNKE--AIYHYRTALKLYPRHASA 411
+L E F+ ++ A+ HY F+ ++ R + A+ H+ A +L
Sbjct: 436 YLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKV 495
Query: 412 LNNLGTLTRDTA----EAKMYYQRALQLHP---QHNRALFNLGNLLKSQEKKEEAITLLK 464
LG RD A+ Y++A +L + A +L L+ E +T +
Sbjct: 496 FCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLSVELEDMEMALAILTTVT 555
Query: 465 DSIKYGP----------------EFADAYSSL-ASLLAEQERFKEAEEI---------YQ 498
G + + A + L A+L A+ + F E + Y
Sbjct: 556 QKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYT 615
Query: 499 TGIKNCPDSSDLHNN--YGVFLVDT-----GLPEKAVAHYQQAIKLSPSHHVAMVNLGRL 551
T +K+ +S+L+ Y VF V G ++AVA YQ IK + A+ LG
Sbjct: 616 TALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGEC 675
Query: 552 YRSLGENSM-------AEEWYKRALQ-----VAHKAEILSPLGALYYNTGRYEEALQIYQ 599
+ + + ++ A ++ ++AL+ + H+A++ L+ G + +Y
Sbjct: 676 HLMMAKAALVDYLDGKAVDYIEKALEYFTCALQHRADV----SCLWKLAG--DACTCLY- 728
Query: 600 EAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECY-RLLSAIYSKQEN 658
A+ PS+ + VL V+ KE +++ G CY R L + +
Sbjct: 729 ---AVAPSKVNV-----HVLGVLLGQKEGKQVLKKNELLHLGG-RCYGRALKLMSTSNTW 779
Query: 659 HDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAW 718
D ++ +A L + N L+E LL+K+ + AV+L+ + W
Sbjct: 780 CDLGINYYRQAQHLAETGSNM---------NDLKE--LLEKSLHCLKKAVRLDSNNHLYW 828
Query: 719 MNMGGIQHIK--GKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVRE 770
+G + G Y A+ + +++Q + + NL L + +++ E
Sbjct: 829 NALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHE 882
Score = 30.4 bits (67), Expect = 6.5
Identities = 32/149 (21%), Positives = 61/149 (40%), Gaps = 16/149 (10%)
Query: 488 ERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVN 547
+ +KEA + +T +K ++ + GV + P++A + Y++A +L P +A
Sbjct: 20 KEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQG 79
Query: 548 LGRLYRSLGENSMAEEW---YKRALQVAHK------AEILSPLGALYYNTGRYEEALQIY 598
L LY + ++ Y++ L + ++ L LYY ++ E + +
Sbjct: 80 LANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEKKHLEVARTW 139
Query: 599 -------QEAAALQPSQRELRLALAQVLA 620
QE A +L L Q LA
Sbjct: 140 HKLIKTRQEQGAENEELHQLWRKLTQFLA 168
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 55.5 bits (132), Expect = 2e-07
Identities = 71/319 (22%), Positives = 131/319 (41%), Gaps = 23/319 (7%)
Query: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGV 516
E A L+ +++ P +ADA+ LA + QE+ K + ++ C +Y +
Sbjct: 509 EAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVK----LCSQSLELCLSYDFKVRDYPL 564
Query: 517 FLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAE 576
+ + +K + AIK + H+AM G + +G ++ +++ K + +H+
Sbjct: 565 YHLIKAQSQKKMGEIADAIK---TLHMAMSLPG--MKRIGASTKSKD-RKTEVDTSHRLS 618
Query: 577 ILSPLGALYYNTGRYEEALQIYQEAA-ALQPSQRELR--LALAQVLAVMGQTKEAEKMTN 633
I L ++ G EA ++ Q+A + E+R +A A + G + A +
Sbjct: 619 IFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALSILQ 678
Query: 634 HIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLRE 693
++ +E+ +E ++ IY K + + + +P+ F G+
Sbjct: 679 NVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPR----SFLLLGDAYMN 734
Query: 694 QNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKL--- 750
++A +Y A+ NP MG Y A YYE AL+ + L
Sbjct: 735 ILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNYLCYD 794
Query: 751 LKENLAKL---DRLEKRLQ 766
L E L KL D+ EK LQ
Sbjct: 795 LAELLLKLKWYDKAEKVLQ 813
Score = 54.7 bits (130), Expect = 3e-07
Identities = 72/352 (20%), Positives = 141/352 (40%), Gaps = 39/352 (11%)
Query: 448 NLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDS 507
+L +Q E A+++L++ P F +A +A + + + K +Y T + +
Sbjct: 662 DLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKM---LYITCFREIAER 718
Query: 508 SDLHNNYGVFLVDTGL----PEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEE 563
++ + L D + PE+A+ Y+QA+ +P +G+ SMA
Sbjct: 719 MANPRSF-LLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAIT 777
Query: 564 WYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQP--------SQRELRLAL 615
+Y+ AL+ K + L L Y++A ++ Q A A +P ++ L
Sbjct: 778 YYEAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLL 837
Query: 616 AQVLAVMGQTKEA-----------EKMTNHIVSEETGCLECYRLLSAIYS--------KQ 656
A+V + M + +A ++ + E+ + + L+A Q
Sbjct: 838 AKVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQ 897
Query: 657 ENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQ 716
+++KA+ +AL D K++ EL Q+ D + +Q + D
Sbjct: 898 RDYEKAIKFYREALVHCETDNKIMLEL----ARLYLAQDDPDSCLRQCALLLQSDQDNEA 953
Query: 717 AWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEV 768
A M M + K Y A + ++ L+ PD+ + L L R +L++V
Sbjct: 954 ATMMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDV 1005
Score = 31.6 bits (70), Expect = 2.9
Identities = 44/196 (22%), Positives = 84/196 (42%), Gaps = 29/196 (14%)
Query: 533 QAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGA-LYYNT--- 588
Q + L S +V + + LY E + E+ + + + + + P A L+YN
Sbjct: 236 QRLLLQDSQNVEALRMQALYYVCREGDI-EKASTKLENLGNTLDAMEPQNAQLFYNITLA 294
Query: 589 -----GRYEEALQ----IYQEAAALQPSQRELRLALAQVLAVMGQTKEAEK-------MT 632
GR + LQ + + A +L P Q E L + + G+ KEA K +
Sbjct: 295 FSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLD 354
Query: 633 NHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVI--SELFFTKGNQ 690
VS G ++C I + ++ D+ L+ +++ Q K ++I + K N+
Sbjct: 355 ETSVSALVGFIQC----QLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNK 410
Query: 691 LREQ--NLLDKAFESY 704
+E+ NLL+ +++
Sbjct: 411 RQEEVINLLNDVLDTH 426
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,520,152
Number of Sequences: 37866
Number of extensions: 1310281
Number of successful extensions: 6772
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 5611
Number of HSP's gapped (non-prelim): 774
length of query: 774
length of database: 18,247,518
effective HSP length: 110
effective length of query: 664
effective length of database: 14,082,258
effective search space: 9350619312
effective search space used: 9350619312
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.