Guide to the Human Genome
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Search of human proteins with 82880656

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
         (955 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap...  1870   0.0  
gi|82880654 coiled-coil domain containing 46 isoform b [Homo sap...   301   2e-81
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    142   1e-33
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    139   1e-32
gi|71061468 centromere protein E [Homo sapiens]                       136   8e-32
gi|148746195 trichohyalin [Homo sapiens]                              131   3e-30
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   129   2e-29
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   128   2e-29
gi|32698688 citron [Homo sapiens]                                     127   4e-29
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   127   4e-29
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   127   4e-29
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   127   4e-29
gi|28416946 myosin 18A isoform a [Homo sapiens]                       127   5e-29
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   127   6e-29
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   126   1e-28
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   126   1e-28
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   126   1e-28
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]             126   1e-28
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   125   2e-28
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            125   2e-28
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   125   2e-28
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   125   2e-28
gi|42794779 myosin 18A isoform b [Homo sapiens]                       125   2e-28
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   124   4e-28
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   123   9e-28
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   122   1e-27
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]        122   1e-27
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]        122   1e-27
gi|210032790 hypothetical protein LOC27146 [Homo sapiens]             122   1e-27
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]   122   1e-27

>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
           sapiens]
          Length = 955

 Score = 1870 bits (4844), Expect = 0.0
 Identities = 955/955 (100%), Positives = 955/955 (100%)

Query: 1   MEVGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRTERQRCALWIRKLCEPSGTGAGIMGR 60
           MEVGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRTERQRCALWIRKLCEPSGTGAGIMGR
Sbjct: 1   MEVGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRTERQRCALWIRKLCEPSGTGAGIMGR 60

Query: 61  KNRNLYAKLLLHMLKRGALEGPFTHRPEPGTLKILPSYMSIYFDEPNPARAKGSSPEGLP 120
           KNRNLYAKLLLHMLKRGALEGPFTHRPEPGTLKILPSYMSIYFDEPNPARAKGSSPEGLP
Sbjct: 61  KNRNLYAKLLLHMLKRGALEGPFTHRPEPGTLKILPSYMSIYFDEPNPARAKGSSPEGLP 120

Query: 121 AWVLGELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHREDG 180
           AWVLGELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHREDG
Sbjct: 121 AWVLGELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHREDG 180

Query: 181 QNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKS 240
           QNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKS
Sbjct: 181 QNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKS 240

Query: 241 SSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTL 300
           SSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTL
Sbjct: 241 SSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTL 300

Query: 301 YRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLH 360
           YRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLH
Sbjct: 301 YRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLH 360

Query: 361 NAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQL 420
           NAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQL
Sbjct: 361 NAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQL 420

Query: 421 TGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLL 480
           TGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLL
Sbjct: 421 TGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLL 480

Query: 481 QTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
           QTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQM
Sbjct: 481 QTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540

Query: 541 EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD 600
           EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD
Sbjct: 541 EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD 600

Query: 601 AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660
           AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ
Sbjct: 601 AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660

Query: 661 IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA 720
           IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA
Sbjct: 661 IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA 720

Query: 721 QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
           QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM
Sbjct: 721 QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780

Query: 781 KIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQL 840
           KIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQL
Sbjct: 781 KIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQL 840

Query: 841 AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI 900
           AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI
Sbjct: 841 AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI 900

Query: 901 TYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGRR 955
           TYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGRR
Sbjct: 901 TYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGRR 955


>gi|82880654 coiled-coil domain containing 46 isoform b [Homo
           sapiens]
          Length = 211

 Score =  301 bits (771), Expect = 2e-81
 Identities = 170/214 (79%), Positives = 177/214 (82%), Gaps = 13/214 (6%)

Query: 742 SQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANS 801
           S ++ Q + L  +REE       E       LK   +  K  LK+          +KANS
Sbjct: 11  SAKENQALRLIEMREENGNVPKTEQ---AGSLKPLRDTGKSNLKE----------KKANS 57

Query: 802 KLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLI 861
           KLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLI
Sbjct: 58  KLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLI 117

Query: 862 RDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQ 921
           RDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQ
Sbjct: 118 RDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQ 177

Query: 922 ELEDTISSLKSQVNFLQKRASILQEELTTYQGRR 955
           ELEDTISSLKSQVNFLQKRASILQEELTTYQGRR
Sbjct: 178 ELEDTISSLKSQVNFLQKRASILQEELTTYQGRR 211



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 27/112 (24%), Positives = 58/112 (51%)

Query: 479 LLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKF 538
           L + K ++ +  +++E+    +K+S +I EL+  +  LK++  + +L  +++L+D   KF
Sbjct: 50  LKEKKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKF 109

Query: 539 QMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTE 590
           + EK  L    ++    LQ EL+      +    K +    E +EQ+T + +
Sbjct: 110 EDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQ 161



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 42/180 (23%), Positives = 87/180 (48%), Gaps = 7/180 (3%)

Query: 658 EQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENL-EKQLRAANMEHENQIQEFK 716
           E Q + L +E  +E  ++ +   A     +RD  +   NL EK+  +   + E +  +  
Sbjct: 14  ENQALRL-IEMREENGNVPKTEQAGSLKPLRDTGKS--NLKEKKANSKLKQIEKEYTQKL 70

Query: 717 KRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAE 776
            + +Q+IA+++  +  L+EE        +++L ++    E+EK++  R+++  +  L+ E
Sbjct: 71  AKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDE 130

Query: 777 SEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKL--AKSSQIIAELQTTISSLKEE 834
            E    +++          LE +  ++  I +EY  KL     + +  EL+ TISSLK +
Sbjct: 131 LENRSNQVRCAEKKLQHKELE-SQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQ 189



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 42/186 (22%), Positives = 85/186 (45%), Gaps = 19/186 (10%)

Query: 365 EMEQEKFDLQKQHTENIQELLEDT----------NVRLNKMESEYMAQTQSTNHMIKELE 414
           EM +E  ++ K       + L DT          N +L ++E EY  +   ++ +I EL+
Sbjct: 22  EMREENGNVPKTEQAGSLKPLRDTGKSNLKEKKANSKLKQIEKEYTQKLAKSSQIIAELQ 81

Query: 415 ARVQQLTGEAENSNLQRQKLIQ---EKAELERCYQITCSELQEVKARRNTLHKEKDHLVN 471
             +  L  E     L  ++ +Q   +K E E+  Q+     Q +K  ++ L + + + V 
Sbjct: 82  TTISSLKEENSQQQLAAERRLQDVRQKFEDEK-KQLIRDNDQAIKVLQDEL-ENRSNQVR 139

Query: 472 DYEQNMKLLQTKYDADINLLKQEH--ALSASKASSMIEELEQNVCQLKQQLQESELQRKQ 529
             E+ ++  + +    I  ++QE+   L     +S+ +ELE  +  LK Q+  + LQ++ 
Sbjct: 140 CAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV--NFLQKRA 197

Query: 530 QLRDQE 535
            +  +E
Sbjct: 198 SILQEE 203



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 39/156 (25%), Positives = 77/156 (49%), Gaps = 25/156 (16%)

Query: 603 LEEFKRQVELNS-EKVYAEMKEQMEKVEADL-TRSKSLREKQSKEFLW---QLEDIRQRY 657
           L+E K   +L   EK Y +   +  ++ A+L T   SL+E+ S++ L    +L+D+RQ++
Sbjct: 50  LKEKKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKF 109

Query: 658 EQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKK 717
                      E EK  L++    + D  ++  + E+EN   Q+R A  + +++  E ++
Sbjct: 110 -----------EDEKKQLIR----DNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQE 154

Query: 718 RDAQVIADMEAQVH-----KLREELINVNSQRKQQL 748
           +   +  + E ++       LR+EL +  S  K Q+
Sbjct: 155 QITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV 190



 Score = 34.3 bits (77), Expect = 0.57
 Identities = 37/142 (26%), Positives = 70/142 (49%), Gaps = 16/142 (11%)

Query: 542 KSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADA 601
           KS+LK   EKKA+    +++K  E TQK + K  + + E +  ++ + E    Q   A+ 
Sbjct: 47  KSNLK---EKKANSKLKQIEK--EYTQK-LAKSSQIIAELQTTISSLKEENSQQQLAAER 100

Query: 602 ALEEFKRQVELNSEKVYAEMKEQMEKVEADL-TRSKSLREKQSK------EFLWQLEDIR 654
            L++ +++ E   +++  +  + ++ ++ +L  RS  +R  + K      E   Q+  IR
Sbjct: 101 RLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIR 160

Query: 655 QRYEQQIVEL---KLEHEQEKT 673
           Q YE ++  L    L  E E T
Sbjct: 161 QEYETKLKGLMPASLRQELEDT 182



 Score = 33.9 bits (76), Expect = 0.75
 Identities = 41/176 (23%), Positives = 82/176 (46%), Gaps = 23/176 (13%)

Query: 177 REDGQNITPKICEVYSKKSPVSLDDSDI-EARLNSWNLGIENP---RYLRQKPIPVSLMT 232
           RE+  N+ PK  +  S K       S++ E + NS    IE     +  +   I   L T
Sbjct: 24  REENGNV-PKTEQAGSLKPLRDTGKSNLKEKKANSKLKQIEKEYTQKLAKSSQIIAELQT 82

Query: 233 PKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEA--KFHEEKLKLQQKHDADV---QKIL 287
              SL++ +S           +++L  + ++ +   KF +EK +L + +D  +   Q  L
Sbjct: 83  TISSLKEENS-----------QQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDEL 131

Query: 288 ERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQ--VIRETKEDQIAELK 341
           E ++N++   +   + K+ E++E I  + ++ +T ++      +R+  ED I+ LK
Sbjct: 132 ENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLK 187


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  142 bits (358), Expect = 1e-33
 Identities = 190/800 (23%), Positives = 355/800 (44%), Gaps = 122/800 (15%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQ--QKHDADVQKILERKNNEIEELKTLYRSKQHE--- 307
            +++EL+     +EA+  EE+ + Q  Q     +Q+ ++    ++EE ++  +  Q E   
Sbjct: 909  KKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT 968

Query: 308  TEETIRKLEKKVQTLIRD--CQVIRETK--EDQIAELK-KICEQSTESLNNDWEKKLHNA 362
            TE  ++KLE++ Q ++ D  C++ +E K  ED+IAE    + E+  +S +    K  H A
Sbjct: 969  TEAKLKKLEEE-QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027

Query: 363  VAEMEQEKF---DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQ 419
            +    +E+    + Q+Q  E  +  LE  +  L+   +E  AQ       + + E  +Q 
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087

Query: 420  LTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ---- 475
                 E    Q+   +++  ELE        +L+  +A RN   K+K  L  + E     
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147

Query: 476  ---------NMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQ 526
                       + L++K + ++N+LK+     A    + I+E+ Q   Q  ++L E   Q
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207

Query: 527  RKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELD---KGKEDTQKKIHKFEEALKEKEE 583
             K+       K  +EK+  K   E +  +L +E+    +GK D++ K  K E  L+E + 
Sbjct: 1208 TKRV------KANLEKA--KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ- 1258

Query: 584  QLTRVTEVQRLQAQQADAALEEFKRQVELN--------SEKVYAEMKEQMEKVEADLTRS 635
               +  E +R++ + AD      K QVEL+        S+   +++ +    +E+ L  +
Sbjct: 1259 --VKFNEGERVRTELADKVT---KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313

Query: 636  KSLREKQSKEFLW------QLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRD 689
            + L ++++++ L       Q+ED +  + +Q     LE E+E  H L++  A   + V D
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEKNSFREQ-----LEEEEEAKHNLEKQIATLHAQVAD 1368

Query: 690  HEREIEN--------------LEKQLRAANMEHENQIQEFKK------RDAQVIADMEAQ 729
             ++++E+              L+K L   +  HE ++  + K      R  Q + D+   
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428

Query: 730  VHKLREELINVNSQRK---QQLVE---LGLLREEEKQRA---TREHEIVVNKL-----KA 775
            +   R+   N+  ++K   Q L E   +     EE+ RA    RE E     L     +A
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA 1488

Query: 776  ESEKMKIE-LKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEE 834
              +K ++E L K    E E  +   +   K + +    K A   Q+  E++T +  L++E
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV-EEMKTQLEELEDE 1547

Query: 835  -------------NSQQQLAA-ERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSN 880
                         N Q   A  ER LQ   ++ E++KKQL+R   +    L+DE + RS 
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607

Query: 881  QVRCAEKKLQH--KELESQEQITYIRQEYETKLKGLMPASLR---QELEDTISS---LKS 932
             V  A KKL+   K+LE+        ++   K    + A ++   +EL+DT +S   + +
Sbjct: 1608 AV-AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666

Query: 933  QVNFLQKRASILQEELTTYQ 952
            Q    +K+   ++ E+   Q
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQ 1686



 Score =  116 bits (290), Expect = 1e-25
 Identities = 152/664 (22%), Positives = 310/664 (46%), Gaps = 99/664 (14%)

Query: 314  KLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKL--HNAVAEMEQEKF 371
            +L  KV+ L+   QV R+ +E    E         E L    EK+L   N + EME  + 
Sbjct: 829  RLFTKVKPLL---QVSRQEEEMMAKE---------EELVKVREKQLAAENRLTEMETLQS 876

Query: 372  DLQKQHTENIQELLEDTNV--RLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
             L  +  +  ++L  +T +     ++ +   A+ Q    +  +LEARV++     ++   
Sbjct: 877  QLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA 936

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEK---DHLVNDYEQNMKLLQTKYDA 486
            +++K+ Q   ELE        +L+E ++ R  L  EK   +  +   E+   +L+   D 
Sbjct: 937  EKKKMQQNIQELEE-------QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILE---DQ 986

Query: 487  DINLLKQEHALS---ASKASSMIEELEQN--VCQLKQQLQESELQRKQQLRDQENKFQ-M 540
            +  L K++  L    A   +++ EE E++  + +LK + +      +++LR +E + Q +
Sbjct: 987  NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL 1046

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD 600
            EK+  K   E  + DL  ++     + Q +I + +  L +KEE+L           Q A 
Sbjct: 1047 EKTRRK--LEGDSTDLSDQI----AELQAQIAELKMQLAKKEEEL-----------QAAL 1089

Query: 601  AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660
            A +EE   Q  +  +K+  E++ Q+ +++ DL   ++ R K  K    Q  D+ +  E +
Sbjct: 1090 ARVEEEAAQKNMALKKI-RELESQISELQEDLESERASRNKAEK----QKRDLGE--ELE 1142

Query: 661  IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA 720
             ++ +LE   + T   Q+  +++       E+E+  L+K L      HE QIQE +++ +
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKR-------EQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEK--QRATREHEIVVNKLKAESE 778
            Q + ++  Q+ + +    N+   ++    E G L  E K   +   + E    K++A+ +
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255

Query: 779  KMKIELKKTHAAETEMT---------LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTIS 829
            +++++  +     TE+          L+     L Q + + ++     S + ++LQ T  
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE 1315

Query: 830  SLKEENSQQQLAAERRLQDVRQKFEDEK---KQLIRDNDQAIKVLQDELENRSNQVRCAE 886
             L+EEN +Q+L+   +L+ V    EDEK   ++ + + ++A   L+ ++     QV   +
Sbjct: 1316 LLQEEN-RQKLSLSTKLKQV----EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370

Query: 887  KKLQHKE--LESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASIL 944
            KK++     LE+ E+   ++++ +  L+G     L Q  E+ +++       L+K  + L
Sbjct: 1371 KKMEDSVGCLETAEE---VKRKLQKDLEG-----LSQRHEEKVAAYDK----LEKTKTRL 1418

Query: 945  QEEL 948
            Q+EL
Sbjct: 1419 QQEL 1422



 Score =  115 bits (288), Expect = 2e-25
 Identities = 156/759 (20%), Positives = 338/759 (44%), Gaps = 128/759 (16%)

Query: 253  REKELDM--KTKMMEAKFHEEKLK-LQQKHDADVQKILE------RKNNEIEELKTLYRS 303
            RE+E+++  KT   EAK HE +++ ++QKH   V+++ E      R    +E+ K    +
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN 1224

Query: 304  KQHETEETIRKL----------EKKVQTLIRDCQV-------IRETKEDQIAELKKICEQ 346
            ++ E    ++ L           KKV+  +++ QV       +R    D++ +L+   + 
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284

Query: 347  STESLNNDWEK--KLHNAVAEMEQEKFDLQKQ-HTENIQELLEDTNVRLNKMES----EY 399
             T  L+    K  KL    + +E +  D Q+    EN Q+L   T ++  + E     E 
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344

Query: 400  MAQTQSTNH-----------MIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQIT 448
            + + +   H            + +++ +++   G  E +   ++KL ++   L + ++  
Sbjct: 1345 LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEK 1404

Query: 449  CSELQEVKARRNTLHKEKDHLVNDYEQ------NMKLLQTKYDADINLLKQEHALSAS-- 500
             +   +++  +  L +E D L+ D +       N++  Q K+D    LL +E  +SA   
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD---QLLAEEKTISAKYA 1461

Query: 501  ----KASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDL 556
                +A +   E E     L + L+E+ +++K +L     +F+ E               
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEA-MEQKAELERLNKQFRTE--------------- 1505

Query: 557  QSELDKGKEDTQKKIHKFEEALKEKEEQLTRV-TEVQRLQAQQADAALEEFKRQVELNSE 615
              +L   K+D  K +H+ E++ +  E+Q+  + T+++ L+ +    A E+ K ++E+N +
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ--ATEDAKLRLEVNLQ 1563

Query: 616  KVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIV---ELKLEHEQEK 672
             + A+ +  ++  +      K    +Q +E   +LED R++    +    +L+++ +  +
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623

Query: 673  THLLQQHNAEKDSLV---RDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQ 729
             H+    N  +D  +   R  + ++++  ++L       E  + + K+ + + +  MEA+
Sbjct: 1624 AHI-DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK-LKSMEAE 1681

Query: 730  VHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHA 789
            + +L+EEL      ++Q   E   L +E    + +    +  K + E+   ++E      
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE------ 1735

Query: 790  AETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTIS-----SLKEENSQQQLAAER 844
               E+  E+ N++L         +L K++  I ++ T ++     + K EN++QQL  + 
Sbjct: 1736 --EELEEEQGNTEL------INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787

Query: 845  R-----LQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRS-------NQVRCAEKKLQ-- 890
            +     LQ++    + + K  I   +  I  L+++L+N +        QVR  EKKL+  
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847

Query: 891  ----HKELESQEQITYIRQEYETKLKGLMPASLRQELED 925
                  E  + EQ      +  T+LK      L+++LE+
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLK-----QLKRQLEE 1881



 Score =  111 bits (277), Expect = 4e-24
 Identities = 145/646 (22%), Positives = 294/646 (45%), Gaps = 91/646 (14%)

Query: 258  DMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNE----------IEELKTLYRSKQHE 307
            D K+  +   F   + +LQ     D Q++L+ +N +          +E+ K  +R +  E
Sbjct: 1293 DSKSSKLTKDFSALESQLQ-----DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE 1347

Query: 308  TEETIRKLEKKVQTLIRDCQVIRETKEDQIA------ELKKICEQSTESLNNDWEKKLHN 361
             EE    LEK++ TL      +++  ED +       E+K+  ++  E L+   E+K+  
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA- 1406

Query: 362  AVAEMEQEKFDLQKQHTENIQELLEDTNVRLN-----KMESEYMAQTQSTNHMIKELEAR 416
            A  ++E+ K  LQ++  + + +L        N     K   + +A+ ++ +    E   R
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR 1466

Query: 417  VQQLTGEAENSNLQRQKLIQE----KAELERCYQITCSELQEVKARRNTLHKEKDHLVND 472
             +    E E   L   + ++E    KAELER  +   +E++++ + ++ + K     V++
Sbjct: 1467 AEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS----VHE 1522

Query: 473  YEQNMKLLQTKYDADINLLKQ-EHALSASKASSMIEELEQNVCQLKQQLQ--------ES 523
             E++ + L+ + +     L++ E  L A++ + +   LE N+  +K Q +        +S
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKL--RLEVNLQAMKAQFERDLQGRDEQS 1580

Query: 524  ELQRKQ---QLRDQENKFQMEKSH------LKHIYEKKAHDLQSELD---KGKEDTQKKI 571
            E ++KQ   Q+R+ E + + E+         +   E    DL++ +D   K +++  K++
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640

Query: 572  HKFEEALKEKEEQL--TRVTEVQRL-QAQQADAALEEFKRQ-VELNSEKVYAEMKEQMEK 627
             K +  +K+   +L  TR +  + L QA++ +  L+  + + ++L  E   AE  ++  +
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700

Query: 628  VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK--LEHEQEKTHL----LQQHNA 681
             E D   +  +     K  L  LE+ ++R E +I +L+  LE EQ  T L    L++ N 
Sbjct: 1701 QERD-ELADEIANSSGKGAL-ALEE-KRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1757

Query: 682  EKD------SLVRDHEREIENLEKQLRAANMEHENQIQEF----KKRDAQVIADMEAQVH 731
            + D      +L R H ++ EN  +QL   N E + ++QE     K +    I  +EA++ 
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817

Query: 732  KLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAE 791
            +L E+L N   +R+             KQ    E ++    L+ + E+   E  K  A +
Sbjct: 1818 QLEEQLDNETKERQAAC----------KQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867

Query: 792  TEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ 837
                L++   +L++ E+E  +  A   ++  EL+    +    N +
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNRE 1913



 Score =  109 bits (272), Expect = 1e-23
 Identities = 147/679 (21%), Positives = 308/679 (45%), Gaps = 112/679 (16%)

Query: 221  LRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHD 280
            L Q     S +T  FS  +S        L     ++L + TK+                 
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL----------------- 1331

Query: 281  ADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIA-- 338
                        ++E+ K  +R +  E EE    LEK++ TL      +++  ED +   
Sbjct: 1332 -----------KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380

Query: 339  ----ELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLN- 393
                E+K+  ++  E L+   E+K+  A  ++E+ K  LQ++  + + +L        N 
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKV-AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439

Query: 394  ----KMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQE----KAELERCY 445
                K   + +A+ ++ +    E   R +    E E   L   + ++E    KAELER  
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499

Query: 446  QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ-EHALSASKASS 504
            +   +E++++ + ++ + K     V++ E++ + L+ + +     L++ E  L A++ + 
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKS----VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK 1555

Query: 505  MIEELEQNVCQLKQQL--------QESELQRKQ---QLRDQENKFQMEKSH------LKH 547
            +   LE N+  +K Q         ++SE ++KQ   Q+R+ E + + E+         + 
Sbjct: 1556 L--RLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613

Query: 548  IYEKKAHDLQSELD---KGKEDTQKKIHKFEEALKEKEEQL--TRVTEVQRL-QAQQADA 601
              E    DL++ +D   K +++  K++ K +  +K+   +L  TR +  + L QA++ + 
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK 1673

Query: 602  ALEEFKRQ-VELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660
             L+  + + ++L  E   AE  ++  + E D   +  +     K  L  LE+ ++R E +
Sbjct: 1674 KLKSMEAEMIQLQEELAAAERAKRQAQQERD-ELADEIANSSGKGAL-ALEE-KRRLEAR 1730

Query: 661  IVEL--KLEHEQEKTHL----LQQHNAEKD------SLVRDHEREIENLEKQLRAANMEH 708
            I +L  +LE EQ  T L    L++ N + D      +L R H ++ EN  +QL   N E 
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790

Query: 709  ENQIQEF----KKRDAQVIADMEAQVHKLREELINVNSQRK---------QQLVELGLLR 755
            + ++QE     K +    I  +EA++ +L E+L N   +R+         ++ ++  LL+
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ 1850

Query: 756  EEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLA 815
             ++++R   +++   +K     +++K +L+     E E   ++AN+  +++++E    L 
Sbjct: 1851 VDDERRNAEQYKDQADKASTRLKQLKRQLE-----EAEEEAQRANASRRKLQRE----LE 1901

Query: 816  KSSQIIAELQTTISSLKEE 834
             +++    +   +SSLK +
Sbjct: 1902 DATETADAMNREVSSLKNK 1920



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 124/537 (23%), Positives = 243/537 (45%), Gaps = 77/537 (14%)

Query: 479  LLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKF 538
            LLQ     +  + K+E  +   +     E     +  L+ QL   +LQ ++QL+  E + 
Sbjct: 837  LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQ-AETEL 895

Query: 539  QMEKSHL-------KHIYEKKAHDLQSELDK----------GKEDTQKKIHKFEEALKEK 581
              E   L       K   E+  HDL++ +++           K+  Q+ I + EE L+E+
Sbjct: 896  CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955

Query: 582  EE-----QLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAE--MKEQMEKVEADLTR 634
            E      QL +VT   +L+  + +  + E  +  +L  EK   E  + E    +  +  +
Sbjct: 956  ESARQKLQLEKVTTEAKLKKLEEEQIILE-DQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 635  SKSLREKQSKE--FLWQLEDIRQRYEQQIVEL---KLEHEQEKTHLLQQHNAEKDSLVRD 689
            SKSL + ++K    +  LE+  +R E+Q  EL   + + E + T L  Q  AE  + + +
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ-IAELQAQIAE 1073

Query: 690  HEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQR---KQ 746
             + ++   E++L+AA    E +  + K    + I ++E+Q+ +L+E+L +  + R   ++
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQ-KNMALKKIRELESQISELQEDLESERASRNKAEK 1132

Query: 747  QLVELGLLRE---------------EEKQRATREHEIVVNKLKAESEKMKIELKKTHAAE 791
            Q  +LG   E               +++ R+ RE E+ + K   E E       KTH A+
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE------AKTHEAQ 1186

Query: 792  TEMTLEKANSKLKQIEKEYTQ------KLAKSSQII----AELQTTISSL---KEENSQQ 838
             +   +K +  ++++ ++  Q       L K+ Q +     EL   +  L   K ++  +
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246

Query: 839  QLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK-----LQHKE 893
            +   E +LQ+++ KF + ++      D+  K LQ EL+N +  +  ++ K          
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTK-LQVELDNVTGLLSQSDSKSSKLTKDFSA 1305

Query: 894  LESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTT 950
            LESQ Q T    + E + K  +   L+Q +ED  +S + Q+   ++    L++++ T
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQ-VEDEKNSFREQLEEEEEAKHNLEKQIAT 1361


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  139 bits (350), Expect = 1e-32
 Identities = 175/819 (21%), Positives = 357/819 (43%), Gaps = 112/819 (13%)

Query: 222  RQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDM-KTKMMEAKFHEEKLKLQQKHD 280
            ++K    SL   +  L+K +   +     R  ++E +  +T+++E +   EK   + K+ 
Sbjct: 527  QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586

Query: 281  A-DVQKILERKNNEIEELKTLYRSKQHETE-ETIRKLEKKVQTLIRDCQVIRETKEDQIA 338
            + D+   LE + N+  +  T+   K H+TE E+++  +  + T     QV+++  + ++ 
Sbjct: 587  SKDLAVHLEAEKNKHNKEITVMVEK-HKTELESLKHQQDALWT--EKLQVLKQQYQTEME 643

Query: 339  ELKKICEQSTESLNNDWEKKLHNAVAEMEQ---EKFDLQKQHTENIQELLEDTNVRLNKM 395
            +L++ CEQ  E+L  D E      + EM +   EK D+++   E++   L +     +K+
Sbjct: 644  KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKL 703

Query: 396  ESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV 455
            E E       T+ M +ELEA++       E  N  +Q++     E E   Q T   L++ 
Sbjct: 704  EEELSVLKDQTDKMKQELEAKMD------EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757

Query: 456  KARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALS------ASKASSMIEEL 509
              +   L KE+D  + +++ +++ L+         L+Q  A         S      +  
Sbjct: 758  INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAY 817

Query: 510  EQNVCQLKQQLQESELQR------------------------KQQLRDQENKFQMEKSHL 545
            E+ + QL+Q+L + E +R                        K Q++D   + + + S +
Sbjct: 818  EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877

Query: 546  KHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
                E+K   L    +   ED  K+  + ++ L EKE  + ++ E Q+ + +     L  
Sbjct: 878  ----EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSA 933

Query: 606  FKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK 665
             +  + + +E+   + K Q +K+E    ++K ++E   K+ L Q   +++  E   +EL 
Sbjct: 934  KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELS 993

Query: 666  LEHEQEKTHLLQQHNAEK------------------DSLVRDHEREIENL----EKQLRA 703
             + +Q    +L+   A                    +SL   H RE+ ++    EK+L  
Sbjct: 994  QKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQ 1053

Query: 704  ANME----HENQIQEFKKRDA---QVIADMEAQVHKLREELINVNSQRKQQLVELGLLRE 756
               E    HE Q+QE ++  A   Q I     +  ++ +E+  +  +  +Q   L  L+E
Sbjct: 1054 QAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113

Query: 757  EEKQRATREHEIVVN--KLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKL 814
            + KQ++   + +  +  KLKA  EK++++L K+    T   L++   +LK + +E  +K+
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT--FLQEQLVELKMLAEEDKRKV 1171

Query: 815  AKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDE 874
               S++ ++L+TT    +   S  +  + + L+D   +F+   ++L    D   K  +  
Sbjct: 1172 ---SELTSKLKTTDEEFQSLKSSHE-KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227

Query: 875  LENRSNQV----------------RCAEKKLQHKEL---------ESQEQITYIRQEYET 909
            LE ++N++                 C  +  + KE          E + Q+  + +E  T
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287

Query: 910  KLKGLMPASLR-QELEDTISSLKSQVNFLQKRASILQEE 947
                   A+ + +E E+ I S+K+ +  L      LQ+E
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE 1326



 Score =  132 bits (333), Expect = 1e-30
 Identities = 167/783 (21%), Positives = 348/783 (44%), Gaps = 96/783 (12%)

Query: 251  RIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEE 310
            R++ +E  +K      + H+E+  L       +Q+ L+ +  E+E++K L+ +++ +   
Sbjct: 287  RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLIT 346

Query: 311  TIRKLEKKVQTLIRD-CQVIRET----------KEDQIAELKKICEQST---ESLNNDWE 356
             +R  +  ++ L +D   VI ET          KE++IA+L+   +Q T   E L    E
Sbjct: 347  QLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE 406

Query: 357  KKLHNAVAEMEQEKFDLQK--QHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELE 414
            K    A  E+E+     QK  +    ++  +++    + K   E     Q     +K+  
Sbjct: 407  KSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466

Query: 415  ARVQQLTGEAENSNLQR---QKLIQEKAELERCYQITCSELQE-VKARRNTLHKEKDHLV 470
              V + + E + + LQ+   ++L +++ EL +  Q    E QE +K        E   + 
Sbjct: 467  VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526

Query: 471  NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQ 530
             + EQ   L   + +     +  E            E     + +L+  L++S  + K Q
Sbjct: 527  QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586

Query: 531  LRDQENKFQMEKS-HLKHI---YEKKAHDLQS-----------ELDKGKEDTQKKIHKFE 575
             +D     + EK+ H K I    EK   +L+S           +L   K+  Q ++ K  
Sbjct: 587  SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646

Query: 576  EALKEKEEQLTRVTEV--QRLQAQQADAALEEFK-RQVELNS-EKVYAEMKEQMEKVEAD 631
            E  ++++E L +  E+  Q    +  +  LE+   +Q EL S     +E+ +   K+E +
Sbjct: 647  EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706

Query: 632  LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHE----------QEKTHLLQQHNA 681
            L+  K   +K  +E   ++++ +  ++QQ+  +  EHE          +++ + L+    
Sbjct: 707  LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766

Query: 682  EKDSLVRDHEREIENLEKQLRAANME------------------HENQIQEFKKRDAQV- 722
            E+D  +++H+  +ENLE  ++ +  E                  HE Q + ++++ AQ+ 
Sbjct: 767  ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE-QTKAYEEQLAQLQ 825

Query: 723  --IADMEAQVHKLREELINVNSQRKQQLVEL--------GLLREEEKQRATREHEIVVNK 772
              + D+E +   L +++  V +Q+K    EL         L+++ EKQ +  E ++   K
Sbjct: 826  QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV---K 882

Query: 773  LKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK 832
               +  + K+E       +T+  L +  + + Q+ +   +++   +Q ++  + +I  L 
Sbjct: 883  SLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN 942

Query: 833  EENSQQQLAAERRLQDVRQKFEDEKKQLIRD-NDQAIKVLQDELENRSNQVRCAEKKLQH 891
            EE   +    E++++ V+QK ++ ++ L +   DQ  K L+ ELEN + ++   EK+   
Sbjct: 943  EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK-LKKELENTALELSQKEKQFNA 1001

Query: 892  KELES--------QEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASI 943
            K LE          + ++ +    + +++ L     R+EL D IS  + ++N   ++A  
Sbjct: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH-RRELNDVISIWEKKLN---QQAEE 1057

Query: 944  LQE 946
            LQE
Sbjct: 1058 LQE 1060



 Score =  124 bits (312), Expect = 3e-28
 Identities = 178/782 (22%), Positives = 339/782 (43%), Gaps = 156/782 (19%)

Query: 249 LSRIREKELDMKTKMMEAKFHEEKLK--LQQKHDADVQKILERKNNEIEELKTLYRSKQH 306
           LS  R K  ++ T     +  ++KL+  L Q  D  +++I E +    EEL+   ++K+H
Sbjct: 150 LSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELR----EELQMDQQAKKH 205

Query: 307 ETEETIRKLEKK---VQTLIRDCQVIRE-------------------------TKED--- 335
             EE    LE+K   +  L     ++++                         TKE+   
Sbjct: 206 LQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPE 265

Query: 336 ---------------------QIAELKKICEQSTESLNNDWEK-KLHNAVAEMEQEKFDL 373
                                ++   + + ++  E++ +  E+  L  +  E  QE+ D 
Sbjct: 266 SDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDE 325

Query: 374 QKQHTENIQEL-----------LEDTNVRLNKMESE---YMAQTQSTNH--------MIK 411
           + Q  E I++L           L D    + ++E +    +A+T+   H         I 
Sbjct: 326 RLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIA 385

Query: 412 ELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVN 471
           +L +R++Q+T + E   L+ QK   E+A  E   +   S  Q+ +  R  L  E D  + 
Sbjct: 386 QLRSRIKQMTTQGE--ELREQKEKSERAAFEE-LEKALSTAQKTEEARRKLKAEMDEQIK 442

Query: 472 DYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQ- 530
             E+  +  +     +++ +KQE  +   K SS     E+ + +L Q+L E EL RK+Q 
Sbjct: 443 TIEKTSEEERISLQQELSRVKQE-VVDVMKKSS-----EEQIAKL-QKLHEKELARKEQE 495

Query: 531 ----LRDQENKFQ------MEKSHLKHIYEKKAHDLQSELDKGKEDTQKKI------HKF 574
               L+ +E +FQ      +EKS  +++   +  + Q  L   + + QKK       +K 
Sbjct: 496 LTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555

Query: 575 EEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQ-----VELNSEKVYAEMKEQMEKVE 629
            +  +E E   TR+ E++       + +L+E K Q     V L +EK     KE    VE
Sbjct: 556 RDLQQEAETYRTRILELE----SSLEKSLQENKNQSKDLAVHLEAEK-NKHNKEITVMVE 610

Query: 630 ADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRD 689
              T  +SL+ +Q   +  +L+ ++Q+Y+ ++ +L+ + EQEK  LL+    +K+ + + 
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK----DKEIIFQA 666

Query: 690 HEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLV 749
           H  E+   EK L   +++ + +++      ++V+       HKL EEL  +  Q  +   
Sbjct: 667 HIEEMN--EKTLEKLDVK-QTELESLSSELSEVLKAR----HKLEEELSVLKDQTDKMKQ 719

Query: 750 ELGLLREEEKQR-------ATREHEIVVNK----LKAESEKMKIELKK--THAAETEMTL 796
           EL    +E+K           +EHE+ + +    LK +  ++++ LK+   H  E +  +
Sbjct: 720 ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV 779

Query: 797 EKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDE 856
           E   + +K+ E E  Q  AK             S +    +Q  A E +L  ++QK  D 
Sbjct: 780 ENLEADIKRSEGELQQASAKLD--------VFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831

Query: 857 KKQLIRDNDQAIKV------LQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETK 910
           + + I    Q  +V      +  EL+    QV+   ++L+ +  E ++++  + Q YE+K
Sbjct: 832 ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891

Query: 911 LK 912
           L+
Sbjct: 892 LE 893



 Score =  117 bits (292), Expect = 7e-26
 Identities = 168/779 (21%), Positives = 331/779 (42%), Gaps = 119/779 (15%)

Query: 228  VSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKIL 287
            + ++T K S  K  S H       I  +E + K K  E K  + K K ++  +   +K+L
Sbjct: 924  IEILTQKLSA-KEDSIH-------ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975

Query: 288  ERKNNEIEELK-TLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQ 346
            +++    +EL+ T     Q E +   + LE            +   + +Q  +++ + E 
Sbjct: 976  DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035

Query: 347  STESLNND---WEKKLHNAVAEMEQEKFDLQKQHTENI-----QELL------EDTNVRL 392
                LN+    WEKKL N  AE  QE  ++Q Q  E       Q++L      E+ N  +
Sbjct: 1036 HRRELNDVISIWEKKL-NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094

Query: 393  NKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSEL 452
              ++ E + Q  + N + ++L+ +   +   A++    +  L + + +L +  +   + L
Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN-TFL 1153

Query: 453  QEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQN 512
            QE       L +E    V++    +K      D +   LK  H  S        + LE  
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTT----DEEFQSLKSSHEKSN-------KSLEDK 1202

Query: 513  VCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIH 572
              + K+  +E  +Q     +  E   + + + L +I   K + + S +       Q +  
Sbjct: 1203 SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH----CQHRTT 1258

Query: 573  KFEEAL-------KEKEEQLTRVTEVQR---LQAQQADAALEEFKRQVEL---------- 612
            K +EAL        E E QL ++TE Q    +  QQA   LEE + Q++           
Sbjct: 1259 KVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVT 1318

Query: 613  ----------NSEKVYAE--------MKEQMEKVEADLTRSKSLREK--QSKEFLWQLED 652
                      N ++  +E         KE  E + A     + L+EK  +      QL D
Sbjct: 1319 EKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTD 1378

Query: 653  IR---------QRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRA 703
            +             E  I  L+ ++++EK  LL Q        V+D   +++ L K+  +
Sbjct: 1379 LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQ--------VQDLSFKVDTLSKEKIS 1430

Query: 704  ANMEHE---NQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQ 760
            A  + +   N+  E+KK+        +  V +L+ +L   + +  ++  ++ LL+EE  Q
Sbjct: 1431 ALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQ 1490

Query: 761  RATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQI 820
            +  R   +   K + E +K K+E KK    ETE  L+   +++ ++E   TQK       
Sbjct: 1491 QNKRFDCL---KGEMEDDKSKME-KKESNLETE--LKSQTARIMELEDHITQK------- 1537

Query: 821  IAELQTTISSLKEENSQQQLAAERRLQDVR--QKFEDEKKQLIRDNDQAIKVLQDELENR 878
              E+++    LK  N Q+ +  +  +Q ++  Q+  +EK   +++ ++ I  L++++ + 
Sbjct: 1538 TIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSM 1597

Query: 879  SNQVRCAEKKLQHKEL---ESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV 934
              ++   +K+L+H  L     +E++  +    E++    + A L+++ E  I+++K Q+
Sbjct: 1598 KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKL-AELKRKAEQKIAAIKKQL 1655



 Score =  112 bits (279), Expect = 2e-24
 Identities = 165/754 (21%), Positives = 322/754 (42%), Gaps = 96/754 (12%)

Query: 259  MKTKMMEAKFHEEKLKLQQKHDADVQK----ILERKNNEIEELKTLYRSKQHETEETIRK 314
            MK ++ E K     L  +Q  D +VQ      L  K   I  L+  Y  ++ E  + ++ 
Sbjct: 1358 MKEELKEKKVEISSLS-KQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQD 1416

Query: 315  LEKKVQTLIRDCQVIRETKED---QIAELKKICEQ-------STESLNNDWEKKLHNAVA 364
            L  KV TL ++     E  +D   + +E KK  +        + + L    E K   A  
Sbjct: 1417 LSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476

Query: 365  EMEQ-----EKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQ 419
            + EQ     E+ D Q +  + ++  +ED   ++ K ES    + +S    I ELE  + Q
Sbjct: 1477 KDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536

Query: 420  LTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKL 479
             T E E+ N   +   Q+K        I   EL +       L +EKD+ V + E+ +  
Sbjct: 1537 KTIEIESLNEVLKNYNQQK-------DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589

Query: 480  LQT-----KYDADINLLKQEHA-LSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRD 533
            L+      K + +    + EH  LS       ++ LE  + + +   + +EL+RK + + 
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL-ESESAAKLAELKRKAEQKI 1648

Query: 534  QENKFQM--EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEV 591
               K Q+  +    +  Y+K      SEL+   ++ ++++H  EE LK  E   +    V
Sbjct: 1649 AAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIV 1708

Query: 592  QRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREK---QSKEFLW 648
             R  A+   A  E+ +   +   +K Y   +E++  ++ +LT  + L ++   + +E + 
Sbjct: 1709 PR-SAKNVAAYTEQEEADSQGCVQKTY---EEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764

Query: 649  QLEDIRQRYEQQIVELKLEHEQEKTH-----------LLQQHNAEKDSLVRDH------- 690
               ++R +Y+++++  KLEH + K H            L++ N +   +V  H       
Sbjct: 1765 SHFEMRCQYQERLI--KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK 1822

Query: 691  -----EREIENLEKQLRAANMEHE--NQIQEFKKRDAQVIADMEAQVHKLREELINVNSQ 743
                 ++ +EN+   ++    E E   QI E K ++       + +VH++  E +    +
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYE 1882

Query: 744  RKQQLVELG------LLREEEKQRATREHEIVVNKLKAESEKMKIELK-KTHAAETEMTL 796
            + Q L ++        L EE  +  ++ H +V  KL +  E    +L+ K   AE E   
Sbjct: 1883 KLQALQQMDGRNKPTELLEENTEEKSKSH-LVQPKLLSNMEAQHNDLEFKLAGAEREK-- 1939

Query: 797  EKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDE 856
            +K   ++ +++K+      +  Q +  L+      +EE  +Q+       +D+  K    
Sbjct: 1940 QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQE------QEDLELKHNST 1993

Query: 857  KKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELES-QEQITYIRQEYETKLKGLM 915
             KQL+R+ +  +   + ELE    +     ++++ + LES QE+   + ++   K   L 
Sbjct: 1994 LKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053

Query: 916  PASLR---------QELEDTISSLKSQVNFLQKR 940
              + R         +E+   +  L++Q+  LQK+
Sbjct: 2054 RTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087



 Score =  100 bits (248), Expect = 8e-21
 Identities = 167/848 (19%), Positives = 366/848 (43%), Gaps = 128/848 (15%)

Query: 117  EGLPAWVLGELETSEHKLNESWKLSSGED-NTLVQSPTDVYSREQYTGKLRVRSHSLSPT 175
            E + A  L + E  E K+  S       D N  +Q+   +  +E     LR +       
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCE 1409

Query: 176  HREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKF 235
              +  Q+++ K+  +  +K        D   + + W    ++     Q    V  +  + 
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR--FTQHQNTVKELQIQL 1467

Query: 236  SLRKSSSFHDDHFLSRIREKELDMKTKM---MEAKFHEEKLKLQQKHD-------ADVQK 285
             L+   ++  D  ++ ++E ELD + K    ++ +  ++K K+++K         +   +
Sbjct: 1468 ELKSKEAYEKDEQINLLKE-ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526

Query: 286  ILE------RKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAE 339
            I+E      +K  EIE L  + ++   + +   ++L +K+Q      Q + E K++++ E
Sbjct: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHF----QELGEEKDNRVKE 1582

Query: 340  LKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEY 399
                 E+   +L N    ++++  AE+E +K +L+  +  +++   E+     +++ESE 
Sbjct: 1583 ----AEEKILTLEN----QVYSMKAELETKKKELEHVNL-SVKSKEEELKALEDRLESES 1633

Query: 400  MAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARR 459
             A+       + EL+ + +Q     + + +++Q L Q + + E+  + T S L E+    
Sbjct: 1634 AAK-------LAELKRKAEQ-----KIAAIKKQLLSQMEEKEEQYKKGTESHLSEL---- 1677

Query: 460  NTLHKEKDHLVNDYEQNMKLLQTKYDADI-------NLLKQEHALSASKASSMIEELEQN 512
            NT  +E++  V+  E+ +K +++     +       N+        A     + +  E+ 
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737

Query: 513  VCQLKQQLQESE--LQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKK 570
            +  L++ L E E  LQR  Q +++      E   ++  Y+++   L+    K  ED Q  
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFE---MRCQYQERLIKLEHAEAKQHED-QSM 1793

Query: 571  IHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK--- 627
            I   +E L+EK ++ + +       AQ  +    +   Q + N E V+ ++++ +++   
Sbjct: 1794 IGHLQEELEEKNKKYSLIV------AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKEL 1847

Query: 628  ----VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEK 683
                +E  +    S   +Q +    ++E++  +YE+     +++   + T LL+++  EK
Sbjct: 1848 TCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907

Query: 684  DSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQ 743
                        +L +    +NME ++   EFK      +A  E +  KL +E++ +   
Sbjct: 1908 SK---------SHLVQPKLLSNMEAQHNDLEFK------LAGAEREKQKLGKEIVRLQKD 1952

Query: 744  ----RKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKT------------ 787
                RK+   EL +L++E  Q   RE      K+K E E ++++   T            
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQE--REE-----KIKQEQEDLELKHNSTLKQLMREFNTQL 2005

Query: 788  --HAAETEMTLEKANSKLKQIE--------KEYTQKLAKSSQIIAELQTTISSLKEENSQ 837
                 E EMT+++  +K +++E        +E  Q L K ++   +L+ T    +E    
Sbjct: 2006 AQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDA 2065

Query: 838  QQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKL-----QHK 892
            ++     +++D++ + E+ +K+  +  +Q      D +     Q + A+K       + K
Sbjct: 2066 REEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLK 2125

Query: 893  ELESQEQI 900
            E E +EQI
Sbjct: 2126 EQEFREQI 2133



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 113/566 (19%), Positives = 241/566 (42%), Gaps = 71/566 (12%)

Query: 412 ELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVN 471
           ++++  + L G +++ N  +++LIQ    +ER       +  E+      L +EK  L  
Sbjct: 119 DMDSEAEDLVGNSDSLN--KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176

Query: 472 DYEQNM-----KLLQTKYDADINL-----LKQEHALSASKASSMIEELEQNVCQLKQQLQ 521
              Q+      ++ + + +  ++      L++E   S  +    I  L+  V  LKQ+L+
Sbjct: 177 ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236

Query: 522 ESE-----LQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEE 576
                   L+   QL  Q   F  E        E    D +  ++ G   + K +   ++
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKE--------ENPESDGEPVVEDGT--SVKTLETLQQ 286

Query: 577 ALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSK 636
            +K +E  L R  E   +Q+ +    L        L SEK    ++EQ+++   +L + K
Sbjct: 287 RVKRQENLLKRCKET--IQSHKEQCTL--------LTSEK--EALQEQLDERLQELEKIK 334

Query: 637 SLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIEN 696
            L   +  + + QL D +   EQ         EQ+K  ++ +   +    +   E EI  
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQL--------EQDKGMVIAETKRQMHETLEMKEEEIAQ 386

Query: 697 LEKQLRAANMEHENQIQEFKKRDAQVIADME---AQVHKLREELINVNSQRKQQLVELGL 753
           L  +++    + E   ++ +K +     ++E   +   K  E    + ++  +Q+  +  
Sbjct: 387 LRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK 446

Query: 754 LREEEK----QRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKE 809
             EEE+    Q  +R  + VV+ +K  SE+   +L+K H  E     ++   KL+  E+E
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE 506

Query: 810 YTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIK 869
           + +++  +   + + Q+    + +E  QQ+  A        ++ E +KK ++ +++  ++
Sbjct: 507 FQEQMKVA---LEKSQSEYLKISQEKEQQESLA-------LEELELQKKAILTESENKLR 556

Query: 870 VLQDELENRSNQV----RCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELED 925
            LQ E E    ++       EK LQ  + +S++   ++  E     K +     + + E 
Sbjct: 557 DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE- 615

Query: 926 TISSLKSQVNFL-QKRASILQEELTT 950
            + SLK Q + L  ++  +L+++  T
Sbjct: 616 -LESLKHQQDALWTEKLQVLKQQYQT 640



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 87/420 (20%), Positives = 198/420 (47%), Gaps = 29/420 (6%)

Query: 267  KFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDC 326
            K +EEK+ + Q++  + +K+L+R   E EE  + +   + + +E + KLE        D 
Sbjct: 1732 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQ 1791

Query: 327  QVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQK--QHTENIQEL 384
             +I   +E+   + KK      + +  +  K    A   +E    D+QK  Q  E   ++
Sbjct: 1792 SMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851

Query: 385  LEDTNVRLN----------KMESEYMAQTQSTNHMIKELEAR------VQQLTGEAENSN 428
            LE     L+          ++E E +         +++++ R      +++ T E   S+
Sbjct: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSH 1911

Query: 429  LQRQKLIQ--EKAELERCYQITCSELQEVKARRNTLHKEKD--HLVNDYEQNMKLLQTKY 484
            L + KL+   E    +  +++  +E ++ K  +  +  +KD   L  +++Q +++L+ +Y
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971

Query: 485  DADIN-LLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKS 543
            D +    +KQE      K +S +++L +   +   QL + E + +  +++  NK Q  ++
Sbjct: 1972 DQEREEKIKQEQEDLELKHNSTLKQLMR---EFNTQLAQKEQELEMTIKETINKAQEVEA 2028

Query: 544  HLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAAL 603
             L   ++++ + L  ++ +  +D ++   ++EE L  +EE++T      + Q ++     
Sbjct: 2029 ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKY 2088

Query: 604  EEFKRQVEL--NSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQI 661
            ++   Q E   N      E++ Q+ +    ++ SK L+E++ +E +  LED  ++YE+ +
Sbjct: 2089 QQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSK-LKEQEFREQIHNLEDRLKKYEKNV 2147



 Score = 38.1 bits (87), Expect = 0.040
 Identities = 43/189 (22%), Positives = 76/189 (40%), Gaps = 17/189 (8%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETI 312
            +E+EL+M  K    K  E + +L + H  +  ++L++   + ++LK   +      EE +
Sbjct: 2008 KEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAK----RYEEIL 2063

Query: 313  RKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWE-----KKLHNAVAEME 367
               E+++   +RD Q        Q+ EL+K  +Q  E   N         +L   +A+  
Sbjct: 2064 DAREEEMTAKVRDLQT-------QLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKT 2116

Query: 368  QEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENS 427
                D  K   +  +E + +   RL K E    A T  T +    L      L GE    
Sbjct: 2117 TLISD-SKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEF 2175

Query: 428  NLQRQKLIQ 436
               R+ L +
Sbjct: 2176 EYLRKVLFE 2184


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  136 bits (343), Expect = 8e-32
 Identities = 189/836 (22%), Positives = 374/836 (44%), Gaps = 83/836 (9%)

Query: 176  HREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPK- 234
            H+E    +  KI E  S+   +  +  + +       +GI+  + L  K         K 
Sbjct: 976  HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD 1035

Query: 235  ----------FSLRKSSSFHDDHFLSRIREKE---LDMKTKMMEAKFHEEKLKLQQKHDA 281
                      FSL +  +       S I EKE    D+K  +     ++E+L+L      
Sbjct: 1036 NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELK 1095

Query: 282  DVQKIL-ERKNNEIEELKTLYRS--KQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIA 338
              Q+I+ + KN+ I++   L R+  +  E EE   KL++K Q L    Q +   +E+   
Sbjct: 1096 KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE---KLKEKSQQLQEKQQQLLNVQEEMSE 1152

Query: 339  ELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVR--LNKME 396
              KKI E   E+L N+ + K    +  ME E+ +L ++  EN +E+   T  R  L +++
Sbjct: 1153 MQKKINE--IENLKNELKNK-ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209

Query: 397  SEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSEL---Q 453
              +  +       I+E+EA   Q   E + +++  ++  +   EL R      +++   Q
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269

Query: 454  EVKARRNTLHKEKDHLVNDYE--QNMKLLQTKYDA--DINLLKQEHALSASKASSMIEEL 509
            +++     L +E   L  + E   N+K +    +   ++ LL ++   S +K S+ +  +
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ---STTKDSTTLARI 1326

Query: 510  EQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQK 569
            E    +L ++ QES+ + K   ++++N        +K   E K   L+  + +     Q+
Sbjct: 1327 EMERLRLNEKFQESQEEIKSLTKERDNL-----KTIKEALEVKHDQLKEHIRETLAKIQE 1381

Query: 570  KIHKFEEAL--KEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK 627
               K E++L  KEK+ + T++      Q +  D+AL   + ++ L   K   E  ++M+ 
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEME-QFKPKDSALLRIEIEM-LGLSKRLQESHDEMKS 1439

Query: 628  V---EADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEH----EQEKT-HLLQQH 679
            V   + DL R + + + +S +    +++I  ++ +   ELK+ H    EQE+T + L+ +
Sbjct: 1440 VAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499

Query: 680  NAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELIN 739
             +EK       E EI  ++KQL A N + +N+IQE  +++ Q      ++V +   EL  
Sbjct: 1500 LSEK-------ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQ 1552

Query: 740  VNSQRKQ-----QLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEM 794
                RK      Q +E  +L    + + ++E   ++ K K E ++++  L+       E 
Sbjct: 1553 FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKEN 1612

Query: 795  TLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAER------RLQD 848
            T E      +  EKEY      +     E    I  LKE+   Q+L  E       RL  
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQ 1672

Query: 849  VRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYI----- 903
            +  +  +E + + ++ D  ++ +++ L+   +Q++   ++   ++LE QE++  +     
Sbjct: 1673 ILHENLEEMRSVTKERDD-LRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731

Query: 904  -RQEYETKLKGLMP------ASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
              QE   KL+G++       ++++++LE +  +LK+Q   +Q+   I    L   Q
Sbjct: 1732 EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787



 Score =  123 bits (308), Expect = 9e-28
 Identities = 150/727 (20%), Positives = 330/727 (45%), Gaps = 111/727 (15%)

Query: 246  DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYR--- 302
            D  L RI  + L +  ++ E+  H+E   + ++ D D+Q++ E   +E ++LK   +   
Sbjct: 1413 DSALLRIEIEMLGLSKRLQES--HDEMKSVAKEKD-DLQRLQEVLQSESDQLKENIKEIV 1469

Query: 303  SKQHETEETIRKLE---KKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKL 359
            +K  ETEE ++      K+ +  I + +V    KE +I+ ++K      E++N+    KL
Sbjct: 1470 AKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK----QLEAIND----KL 1521

Query: 360  HNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQ 419
             N + E+ +++     +    +QE       ++N+++ ++    ++ +  ++ +E+++ +
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQE-------KVNELK-QFKEHRKAKDSALQSIESKMLE 1573

Query: 420  LTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKL 479
            LT   + S  + Q +I+EK E++R  +               L  E+D L  + ++ +  
Sbjct: 1574 LTNRLQESQEEIQIMIKEKEEMKRVQE--------------ALQIERDQLKENTKEIVAK 1619

Query: 480  LQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQ 539
            ++   + +   LK           + + E ++ +C+++   ++ E Q+     + EN  +
Sbjct: 1620 MKESQEKEYQFLKM----------TAVNETQEKMCEIEHLKEQFETQKL----NLEN-IE 1664

Query: 540  MEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLT---RVTEVQRLQA 596
             E   L  I  +   +++S + K ++D    +   EE LK + +QL    R T  + L+ 
Sbjct: 1665 TENIRLTQILHENLEEMRS-VTKERDD----LRSVEETLKVERDQLKENLRETITRDLEK 1719

Query: 597  QQADAALEEFKRQVELNSEK---VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDI 653
            Q+    +    ++ +   +K   + +E   ++  ++ DL  S    + Q         D+
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ---------DL 1770

Query: 654  RQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQ 713
            + + E +I  + L+ +QE    L+        +V +   ++ N++K L  +N + + +IQ
Sbjct: 1771 KIQEELRIAHMHLKEQQETIDKLR-------GIVSEKTDKLSNMQKDLENSNAKLQEKIQ 1823

Query: 714  EFKKRDAQVIADME--AQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHE---- 767
            E K  + Q+I   +   +  K   E+  +  Q K Q + L  L  E    A + HE    
Sbjct: 1824 ELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE 1883

Query: 768  ------------IVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLA 815
                         V   LK E +++K  L++T A + E+  E   +++  + KE+ + + 
Sbjct: 1884 MKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM--LSKEHKETVD 1941

Query: 816  KSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQK-------FEDEKKQLIRDNDQAI 868
            K  + I+E    IS ++++  + +   ++++Q++++K        ED      + N+   
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001

Query: 869  KVLQDELENRSNQ-VRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTI 927
               Q E +N S Q VR    +L  K  ES E+I  + +E +   +  +  SL+ E +  I
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRR--IKESLKMERDQFI 2059

Query: 928  SSLKSQV 934
            ++L+  +
Sbjct: 2060 ATLREMI 2066



 Score =  108 bits (269), Expect = 3e-23
 Identities = 166/775 (21%), Positives = 326/775 (42%), Gaps = 140/775 (18%)

Query: 262  KMMEAKFHEEKLKLQQKHDADVQKILERKN---------NEIEELKTLYRSKQHETEETI 312
            + +  +  E +LKL++K+D D  + LERK          +EI  LK L +  +   ++  
Sbjct: 515  EQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574

Query: 313  RKLEKKVQTLIRDCQVIRETKEDQIAELKK-ICEQSTESLNNDWEKKLHNA--VAEMEQE 369
             +L  KV+ L          KEDQI +L++ I  Q  E++  D    L +     +M+Q 
Sbjct: 575  NELSSKVELL--------REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQT 626

Query: 370  KFDLQ-------------KQHTENIQELLEDTNVRLNKMESE---YMAQTQSTNHMIKEL 413
             FD +             +     ++E +++      +ME++   Y +Q ++   M  +L
Sbjct: 627  LFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDL 686

Query: 414  EARVQ-------------------------QLTGEAENSNLQRQKLIQEKAELERCYQIT 448
            E  +Q                         +L G+  +   +  K ++E   L R   I 
Sbjct: 687  EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEAL-REEVIL 745

Query: 449  CSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEE 508
             SEL+ + +    L KE    + D  + + ++ ++ D     L  E     S+   ++EE
Sbjct: 746  LSELKSLPSEVERLRKE----IQDKSEELHIITSEKDK----LFSEVVHKESRVQGLLEE 797

Query: 509  LEQN-----VCQLKQQLQESELQRKQQLR-DQENKFQMEKSHLKHIYE------KKAHDL 556
            + +        Q   +  + E Q  + L  D E K++M     + + +      K+A   
Sbjct: 798  IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857

Query: 557  QSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEK 616
             S L   K +   K  + +E  +E +E+L  + +++  Q +  D+ L+  +R+  L +EK
Sbjct: 858  DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE-QLENRDSTLQTVEREKTLITEK 916

Query: 617  VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLL 676
                +++ +E+V+  LT+ K    KQ +E L    D  +      V + ++ +++  + L
Sbjct: 917  ----LQQTLEEVKT-LTQEKD-DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL 970

Query: 677  QQHNAEKDSLVRDHEREIENLEKQLR---AANMEHENQIQEFKKRDAQVIA------DME 727
            +         ++ H+  I  L+ ++    + N+  E    E K    Q +       D+E
Sbjct: 971  ES--------LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022

Query: 728  AQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKT 787
            A+  +     +  N   +QQ     L++E+ + +   E  I      AE E++K +LK+ 
Sbjct: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVI------AEKEQLKTDLKE- 1075

Query: 788  HAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQ 847
                 EMT+E    +L+ +  E    L K  +I+A  Q    ++K+E    +     RL 
Sbjct: 1076 ---NIEMTIEN-QEELRLLGDE----LKKQQEIVA--QEKNHAIKKEGELSRTC--DRLA 1123

Query: 848  DVRQKFEDEKKQLIRDNDQAIKVLQD---------ELENRSNQVRCAEKKLQHKELESQE 898
            +V +K +++ +QL     Q + V ++         E+EN  N+++  E  L+H E E  E
Sbjct: 1124 EVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE 1183

Query: 899  QITYIRQEYE-----TKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEEL 948
                + + YE     TK + ++   L++  E     L+  +  ++      +EEL
Sbjct: 1184 LAQKLNENYEEVKSITKERKVL-KELQKSFETERDHLRGYIREIEATGLQTKEEL 1237



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 157/743 (21%), Positives = 322/743 (43%), Gaps = 136/743 (18%)

Query: 270  EEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVI 329
            +E+L++   H  + Q+ +++    + E      + Q + E +  KL++K+Q L       
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL------- 1825

Query: 330  RETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTN 389
             +  E Q+  LKK          N+ +KK    V+EMEQ    L+KQ        ++D +
Sbjct: 1826 -KANEHQLITLKKDV--------NETQKK----VSEMEQ----LKKQ--------IKDQS 1860

Query: 390  VRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 449
            + L+K+E E +   Q  +  ++E+++ ++      E  NL+R   ++E  +LER      
Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMK------ERDNLRR---VEETLKLER--DQLK 1909

Query: 450  SELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL 509
              LQE KAR   + +E         +  ++L  ++   ++ L+++ +    + S + ++L
Sbjct: 1910 ESLQETKARDLEIQQEL--------KTARMLSKEHKETVDKLREKISEKTIQISDIQKDL 1961

Query: 510  EQNVCQLKQQLQESELQRKQQLRDQE-----NKFQMEKSHLKHIYEKKAHDLQSELDKGK 564
            +++  +L++++QE + +  Q LR +E     +K   E   LK  +E +   +QS +    
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQS-VRMDN 2020

Query: 565  EDTQKKIHKFEEALK---EKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
                KK+H+  E ++   ++ ++L R+ E  +++  Q  A L E   +   N +      
Sbjct: 2021 FQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ--VKPE 2078

Query: 622  KEQMEKVEADLTRSKSLREKQS--KEFLWQLEDIRQRYE-QQIVELKLEHEQEKTHLLQQ 678
            K  +   +  LT  +SLREK S  KE L +  ++   YE    + L LE E E    L  
Sbjct: 2079 KRLLSDGQQHLT--ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM 2136

Query: 679  HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQ---VHKLRE 735
                  SL     + IE L    +  +ME    +++ K   + V    E Q   ++K   
Sbjct: 2137 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM 2196

Query: 736  ELINVNSQRKQQLVELGLLRE--EEKQRATRE-----------HEIVVNKLKAESEKMKI 782
            + I+   ++K+ L+++  L++  +   R  R+            EI+ +  ++E   +K 
Sbjct: 2197 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT 2256

Query: 783  ELKKTHAAETEMT-------------------LEKANSKLKQIE-----------KEYTQ 812
            E ++  +   EMT                   ++K N ++ Q+             E T+
Sbjct: 2257 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE 2316

Query: 813  KLAKSSQIIAELQTTISSLKEENS---------QQQLAAERRLQDVRQKFEDEKKQLIRD 863
               +S+ I  E +  + SLKE+N          +  LA+  ++    Q   D K   +  
Sbjct: 2317 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQ---DNKNPHV-- 2371

Query: 864  NDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQEL 923
              +A ++  +++    N +  A++   HKE +       I+ + E ++   + A L+ ++
Sbjct: 2372 TSRATQLTTEKIRELENSLHEAKESAMHKESK------IIKMQKELEVTNDIIAKLQAKV 2425

Query: 924  EDT---ISSLKSQVNFLQKRASI 943
             ++   +   K  +  LQ + ++
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVAL 2448



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 171/837 (20%), Positives = 346/837 (41%), Gaps = 114/837 (13%)

Query: 168 RSHSLSPTHREDGQNITPKICEVYSKKSPVSLDD---SDIEARLNSWNLGIENPRYLRQK 224
           RSH++     E  +   P  CE   K S ++L D   S+  A+  +  + ++    + + 
Sbjct: 202 RSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRS 261

Query: 225 PIPVSLMTPKFSLRKSSSF--HDDHFLSRIREKEL--DMKTKMM----EAKFHEEKLKLQ 276
              +  +  K S  +   F  + D  L+RI +  L  + KT+++       F E    LQ
Sbjct: 262 LFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQ 321

Query: 277 QKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQ 336
               A   K     N E+   + L +  + E  +  ++LE+   +L    Q + + +  Q
Sbjct: 322 FASTAKYMKNTPYVN-EVSTDEALLKRYRKEIMDLKKQLEEV--SLETRAQAMEKDQLAQ 378

Query: 337 IAELKKICEQ-STESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKM 395
           + E K + ++   E + N     + ++   ++QE   L+ +    +   L     ++NKM
Sbjct: 379 LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQE---LKAKRKRRVTWCLG----KINKM 431

Query: 396 E-SEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEK----AELERCYQITCS 450
           + S Y  Q     ++  +       L  E + S      +        +E+E        
Sbjct: 432 KNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLL 491

Query: 451 ELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELE 510
             + +++  N+L  + D+LV DYEQ    L+T+        K+E  L   +         
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQ----LRTE--------KEEMELKLKE--------- 530

Query: 511 QNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKK 570
                 K  L E E   ++  +DQE +   E S+LK        +L    +   +D + +
Sbjct: 531 ------KNDLDEFEALERKTKKDQEMQLIHEISNLK--------NLVKHAEVYNQDLENE 576

Query: 571 IHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVY--AEMKEQM--- 625
           +    E L+EKE+Q      +++LQ       LE  K  +  + E +    +MK+ +   
Sbjct: 577 LSSKVELLREKEDQ------IKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630

Query: 626 EKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDS 685
           E V  D  R  +    ++ E   +++++   Y+Q   +++L   Q +     Q + EK+ 
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE- 689

Query: 686 LVRDHEREIENLEKQLRA-------ANMEHENQIQEFKKRDAQVIADMEAQVHKLREELI 738
            ++    EI  L   +          N+E E +I + +K   + + + EA    LREE+I
Sbjct: 690 -LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA----LREEVI 744

Query: 739 NVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIE------LKKTHAAET 792
            + S+ K    E+  LR+E + ++   H I   K K  SE +  E      L++    + 
Sbjct: 745 -LLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKD 803

Query: 793 EMTLEKANSK--------LKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ--QQLAA 842
           ++   ++N K         K +  ++ QK     +    +   I +L +E  +    L A
Sbjct: 804 DLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA 863

Query: 843 ERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK---LQHKELESQEQ 899
            +     + +   EK + +++    ++ L+++LENR + ++  E++   +  K  ++ E+
Sbjct: 864 LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923

Query: 900 ITYIRQEYETKLKGLMPA------SLRQELEDTIS-SLKSQVNFLQKRASILQEELT 949
           +  + QE +  LK L  +       L+ ++ DT++ ++ +Q        S+ Q + T
Sbjct: 924 VKTLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 146/739 (19%), Positives = 299/739 (40%), Gaps = 102/739 (13%)

Query: 254  EKELDMKTKMMEAKFHE-EKLKLQQKHDADVQKILERKNNEIEELKTLYRS--------- 303
            +K+LD     ++ K  E +K +LQ     +   +  +K NE+E+LK  + +         
Sbjct: 1958 QKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017

Query: 304  --------KQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDW 355
                    K HE+ E IR + K+   L R  + ++  ++  IA L+++  +  ++     
Sbjct: 2018 MDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKP 2077

Query: 356  EKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEA 415
            EK+L   +++ +Q   +  ++    I+ELL+    R ++M+  Y    + +  + KE+E 
Sbjct: 2078 EKRL---LSDGQQHLTESLREKCSRIKELLK----RYSEMDDHYECLNRLSLDLEKEIEF 2130

Query: 416  RVQQLTGEAENSNLQR------QKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHL 469
            + +       N +L        +KL          +     +L+ V +    + +E+   
Sbjct: 2131 QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES 2190

Query: 470  VNDYEQN------------MKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLK 517
            +N +E +            +K+   + D D+   +             IEE+ ++  + +
Sbjct: 2191 INKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESE 2250

Query: 518  QQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDK--------------- 562
                ++E Q+    R +  +F  E  + +   EK  + +Q E D+               
Sbjct: 2251 FPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAI 2310

Query: 563  GKEDTQ---------KKIHKFEEALKEKEEQLTR---VTEVQRLQAQQADAALEEFK--- 607
              E T+         K+  +  ++LKEK E+L +     +       Q +   ++ K   
Sbjct: 2311 MNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPH 2370

Query: 608  ---RQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL 664
               R  +L +EK+  E++  + + +      +S   K  KE L    DI  + + ++ E 
Sbjct: 2371 VTSRATQLTTEKI-RELENSLHEAKESAMHKESKIIKMQKE-LEVTNDIIAKLQAKVHES 2428

Query: 665  K--LEHEQEKTHLLQQHNAEKDSL-VRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQ 721
               LE  +E   +LQ    +K +L  + ++ EIE+L+ +L   ++E     +EF+K  + 
Sbjct: 2429 NKCLEKTKETIQVLQ----DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISA 2484

Query: 722  VIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMK 781
              A +E Q   +R  L+  N +R QQ  +  ++ E    + + +                
Sbjct: 2485 TKATVEYQKEVIR--LLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKA 2542

Query: 782  IELKKTHAAETEMTLEKANSKLK----QIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ 837
            + LK  H     + LEK  SKLK    Q+ K+  + L+ +  +  E++T      +  + 
Sbjct: 2543 LILKSEH-----IRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAH 2597

Query: 838  QQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQ 897
            +Q+  E   +  +      KK+ I  +    + LQD +   S +    + +   K L S 
Sbjct: 2598 KQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSR--SKSLPSP 2655

Query: 898  EQITYIRQEYETKLKGLMP 916
              + Y    ++    GL P
Sbjct: 2656 HPVRY----FDNSSLGLCP 2670



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 72/309 (23%), Positives = 133/309 (43%), Gaps = 48/309 (15%)

Query: 684 DSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQ 743
           ++L++ + +EI +L+KQL   ++E   Q  E K + AQ++ + +       E++ N+   
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAME-KDQLAQLLEEKDLLQKVQNEKIENLT-- 398

Query: 744 RKQQLVELGLLREEEKQRATREHEIV-----VNKLKAESEKMKIEL-----KKTHAAETE 793
             + LV    L  +++ +A R+  +      +NK+K  +   +  +      KTH     
Sbjct: 399 --RMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN 456

Query: 794 MTLEKANS-------------KLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ--- 837
           +  E   S              L +IE     KL     I +EL    +SL+ +      
Sbjct: 457 LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESEL----NSLRADYDNLVL 512

Query: 838 --QQLAAERRLQDVRQKFE---DEKKQLIR--DNDQAIKVLQDELENRSNQVRCAEKKLQ 890
             +QL  E+   +++ K +   DE + L R    DQ ++++  E+ N  N V+ AE   Q
Sbjct: 513 DYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIH-EISNLKNLVKHAEVYNQ 571

Query: 891 HKELESQEQITYIRQEYETKLKGLMPASLRQELE----DTISSLKSQVNFLQKRASILQE 946
             E E   ++  +R E E ++K L      Q+LE    D   SL+S  +  Q + ++   
Sbjct: 572 DLENELSSKVELLR-EKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630

Query: 947 ELTTYQGRR 955
           E      +R
Sbjct: 631 ETVALDAKR 639


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  131 bits (329), Expect = 3e-30
 Identities = 163/740 (22%), Positives = 332/740 (44%), Gaps = 89/740 (12%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDAD-VQKILERKNNEIEELKT-LYRSKQHETEE 310
            RE+E +   +  E +  E++LK +Q+   D +++  E + +E E  K  L R ++ E  E
Sbjct: 427  REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486

Query: 311  TIRKL---EKKVQTLIRDCQVIRETKEDQIAELKKICEQ--------STESLNNDWEKKL 359
               KL   E++ Q   R+ Q+ RE +E +   LK+  E+        S + L  + E++ 
Sbjct: 487  RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546

Query: 360  HNAVAEMEQEKFD-------LQKQHTENIQELL----EDTNVRLNKMESEYMAQTQSTNH 408
               +   E+++ +       L+++  E   +LL    E    RL + + E + Q      
Sbjct: 547  EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606

Query: 409  MIK-ELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKD 467
            + + E E R +Q     E    +RQ+L++ + + ER  Q    E QE + +R    +E++
Sbjct: 607  VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666

Query: 468  HLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIE------ELEQNVCQLKQQLQ 521
             L    EQ +K    +   +  L ++E   +  +  S I       E E +  Q K   +
Sbjct: 667  RL----EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722

Query: 522  ESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDT-----QKKIHKFEE 576
              + + +++ ++QE K +  +S L+   E++AH  Q E ++ ++ T     ++K  +  +
Sbjct: 723  PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782

Query: 577  ------ALKEKEEQLTRVTEVQ----------------RLQAQQADAALEEFKRQVELNS 614
                   L+E+ E+  R  E Q                R Q ++ +  L+  + + +L  
Sbjct: 783  RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842

Query: 615  EKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTH 674
             +   +++E+ + ++ D  R +S  +++ +++ WQLE+ R+R           H      
Sbjct: 843  RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR---------RRHTLYAKP 893

Query: 675  LLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQE---FKKRDAQVIADMEAQVH 731
             LQ+   ++  L+++ E E++  E++ R    E E Q +E    ++ + Q++ + E +  
Sbjct: 894  ALQEQLRKEQQLLQEEEEELQREEREKR-RRQEQERQYREEEQLQQEEEQLLRE-EREKR 951

Query: 732  KLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIE---LKKTH 788
            + +E        +K Q  E  LL EE ++R  +E E    K + E E  + E   L++  
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE---KKYREEEELQQEEEQLLREER 1008

Query: 789  AAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEE----NSQQQLAAER 844
                    E+   K  ++++E  ++L +  +    LQ      +EE      ++QL  E 
Sbjct: 1009 EKRRRQEWERQYRKKDELQQE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067

Query: 845  RLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIR 904
            R    RQ+ E + ++      +  ++L++E E R  Q R  E++ + +E   QE+   +R
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER--ERQCREEEELQQEEEQLLR 1125

Query: 905  QEYETKLKGLMPASLRQELE 924
            +E E + +  +    R+E E
Sbjct: 1126 EEREKRRRQELERQYREEEE 1145



 Score =  131 bits (329), Expect = 3e-30
 Identities = 170/780 (21%), Positives = 349/780 (44%), Gaps = 120/780 (15%)

Query: 249  LSRIREKELDMKTKMMEAKFHEEKLKLQQ-KHDADVQ------KILERKNNEIEELKT-- 299
            L R +E+  D   +  E + HE++ + QQ K D + +      K+ E +  E +E +   
Sbjct: 447  LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506

Query: 300  LYRSKQHETEETIRKLEK--KVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEK 357
            L R ++   E+ +++ E+  ++Q  +R  Q +R  +E++  +L K      E    + E+
Sbjct: 507  LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK----REEEKRLEQER 562

Query: 358  KLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIK-ELEAR 416
            +      E E+ +  L K+  E  Q+       RL + + E + Q      + + E E R
Sbjct: 563  REQRLKREQEERRDQLLKREEERRQQ-------RLKREQEERLEQRLKREEVERLEQEER 615

Query: 417  VQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQN 476
             +Q     E    +RQ+L++ + + ER  Q    E QE + +R    +E++ L    EQ 
Sbjct: 616  REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL----EQR 671

Query: 477  MKLLQTKYDADINLLKQEHALSASKASSMIE------ELEQNVCQLKQQLQESELQRKQQ 530
            +K    +   +  L ++E   +  +  S I       E E +  Q K   +  + + +++
Sbjct: 672  LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731

Query: 531  LRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDT-----QKKIHKFEEAL------K 579
             ++QE K +  +S L+   E++AH  Q E ++ ++ T     ++K  +  + L      +
Sbjct: 732  RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791

Query: 580  EKEEQLTRVTEVQ----------------RLQAQQADAALEEFKRQVELNSEKVYAEMKE 623
            E+ E+  R  E Q                R Q ++ +  L+  + + +L   +   +++E
Sbjct: 792  EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851

Query: 624  QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRY----------------EQQIV----- 662
            + + ++ D  R +S  +++ +++ WQLE+ R+R                 EQQ++     
Sbjct: 852  EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911

Query: 663  ELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKK---RD 719
            EL+ E  +++    Q+    ++  ++  E ++   E++ R    E E Q ++ KK   ++
Sbjct: 912  ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR-RQERERQYRKDKKLQQKE 970

Query: 720  AQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNK------- 772
             Q++ + E +  + +E       + + Q  E  LLREE ++R  +E E    K       
Sbjct: 971  EQLLGE-EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029

Query: 773  ----LKAESEKMKI-ELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTT 827
                L+ E EK ++ E ++ +  E E+  E+     ++ E    Q+L +  +   ELQ  
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ-- 1087

Query: 828  ISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK 887
                +EE    +   E+R +  R++   E+++L ++ +Q   +L++E E R  Q    E+
Sbjct: 1088 ----QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ---LLREEREKRRRQE--LER 1138

Query: 888  KLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
            + + +E   QE+   +R+E E +         RQELE      + +    Q+   +L+EE
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKR--------RRQELE---RQYREEEELQQEEEQLLREE 1187



 Score =  129 bits (323), Expect = 2e-29
 Identities = 147/707 (20%), Positives = 328/707 (46%), Gaps = 84/707 (11%)

Query: 270  EEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVI 329
            +E+L+ +Q+   + ++ L+R+  E E+ +   + +Q+  EE +++ E+++    R+ +  
Sbjct: 896  QEQLRKEQQLLQEEEEELQRE--EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR- 952

Query: 330  RETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTN 389
            R+ +E Q  + KK+ ++  + L  + EK+      +  +E+ +LQ++  + ++E  E   
Sbjct: 953  RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE--- 1009

Query: 390  VRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQ-RQKLIQEKAELERCYQIT 448
                +   E+  Q +  + + +E E   Q L  E E   LQ R++  +E+ EL++  +  
Sbjct: 1010 ---KRRRQEWERQYRKKDELQQEEE---QLLREEREKRRLQERERQYREEEELQQEEEQL 1063

Query: 449  CSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEE 508
              E +E + R+                    L+ +Y  +  L ++E  L   +      +
Sbjct: 1064 LGEERETRRRQE-------------------LERQYRKEEELQQEEEQLLREEPEKRRRQ 1104

Query: 509  LEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKH--IYEKKAHDLQSELDKGKED 566
              +  C+ +++LQ+ E Q  ++ R++  + ++E+ + +   + +++   L+ E +K +  
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164

Query: 567  TQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQA----DAALEEFKRQVELNSEKVYAEMK 622
              ++ ++ EE L+++EEQL R  + +R Q ++     +  L+  KR+     E   +++K
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224

Query: 623  EQMEKVEADLTRSKSLREK-QSKEFLWQLED--IRQRYEQQIVELKLEHEQEKTHLLQQ- 678
             Q E  + +  R   +  K +  E   QLED  +R R  QQ ++  L  +QE+    ++ 
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR 1284

Query: 679  -------HNAEKDSLVRDHEREIENL------EKQLRAANMEHENQIQEFKKR---DAQV 722
                   H  E++ L R+ ++E +        EKQL     E + + QE  ++   + Q+
Sbjct: 1285 RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL 1344

Query: 723  IADMEAQV-------HKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKA 775
            + + E Q         K REE +    Q ++ L E   LR +E++R   + E  +   + 
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404

Query: 776  ESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEEN 835
            E +  +   +K    E +++ ++ + K ++ E++  ++  +   +  E Q      ++  
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464

Query: 836  SQQQLAAERRLQDVRQKFED----EKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQ- 890
             ++QL  ER  Q + ++  D    E++Q +R  ++  K  + EL ++  + +  E++ Q 
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524

Query: 891  ------------HKELESQEQITYIRQEYETKLKGLMPASLRQELED 925
                         ++L  QE+    RQ+ + K +      LRQE E+
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR--EEEQLRQEREE 1569



 Score =  124 bits (312), Expect = 3e-28
 Identities = 150/720 (20%), Positives = 332/720 (46%), Gaps = 58/720 (8%)

Query: 253 REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETI 312
           RE++   + +  +  F EE+ K  +K +     +L ++  +++E +   + +  E EE +
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRET----VLRKEEEKLQEEEPQRQRELQEEEEQL 278

Query: 313 RKLEK------------KVQTLIRDCQVIRETKEDQIAELKKICEQS--TESLNNDWEKK 358
           RKLE+            + Q L R+ Q+ R+ +E++  + ++  EQ    E      E++
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338

Query: 359 LHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELE-ARV 417
           L     E  +++   +++     Q+L  +      + +     Q +    + +E +  R 
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398

Query: 418 QQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNM 477
           QQL  E +   L+R++ ++ + +L R  Q+   + +E   +++   + +  L  + E+  
Sbjct: 399 QQLRREQQ---LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455

Query: 478 KLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENK 537
             L+ + + + +  +QE      K     E  E+ +   +++ +E + +R+QQLR ++ +
Sbjct: 456 DWLKREEETERH--EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513

Query: 538 FQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALK-EKEEQLTRVTEVQRLQA 596
            + ++   +   E+    L+SE    +E  +++    E+ LK E+E++L +    QRL+ 
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERR----EQLLKREEEKRLEQERREQRLKR 569

Query: 597 QQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRS--KSLREKQSKEFLWQLEDIR 654
           +Q +   +  KR+ E   +++    +EQ E++E  L R   + L +++ +E   + E+  
Sbjct: 570 EQEERRDQLLKREEERRQQRL---KREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626

Query: 655 QRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQE 714
           +   QQ+++ + + E+ +  L ++    ++  ++  E E E LE++L+  + E   + + 
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-ERLEQRLKREHEEERREQEL 685

Query: 715 FKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
            ++   Q    +++++ K + +L +    R+ ++      R++E QR  +E E    + +
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP--RKQEGQRRRQEQE--EKRRR 741

Query: 775 AESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYT-QKLAKSSQIIAELQTTISSLKE 833
            ESE    E ++ H  + E          ++  +++T Q  A+        + +      
Sbjct: 742 RESELQWQEEERAHRQQQE----------EEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791

Query: 834 ENSQQQLAAERRLQDVRQKF---EDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQ 890
           E  ++QL AE R Q   Q+F   E+EK+Q  R   +  K LQ   E    Q R   ++LQ
Sbjct: 792 EQRERQLRAEER-QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850

Query: 891 HKE---LESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
            +E    E QE+     Q  + K +  +    R+    T+ +  +    L+K   +LQEE
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEE-RKRRRHTLYAKPALQEQLRKEQQLLQEE 909



 Score =  122 bits (306), Expect = 2e-27
 Identities = 154/723 (21%), Positives = 326/723 (45%), Gaps = 83/723 (11%)

Query: 245  DDHFLSRIREKEL---DMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLY 301
            +  FL    EKE      + +  E +F EE+ +LQ++  A     L+ + + ++E +   
Sbjct: 807  EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ---LQEEEDGLQEDQERR 863

Query: 302  RSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHN 361
            RS++   ++  R   ++ +   R     +   ++Q+ + +++ ++  E L  +  +K   
Sbjct: 864  RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR 923

Query: 362  AVAEME-QEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQL 420
               E + +E+  LQ++  + ++E  E    R  + E +Y           K+L+ + +QL
Sbjct: 924  QEQERQYREEEQLQQEEEQLLRE--EREKRRRQERERQYRKD--------KKLQQKEEQL 973

Query: 421  TGEA--ENSNLQRQKLIQEKAELERCYQITCSELQEVKARRN--TLHKEKDHLVNDYEQN 476
             GE   +    +R+K  +E+ EL++  +    E +E + R+     +++KD L  + EQ 
Sbjct: 974  LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033

Query: 477  MKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQEN 536
            ++  + K         QE      +   + +E EQ + + ++  +  EL+R  Q R +E 
Sbjct: 1034 LREEREKRRL------QERERQYREEEELQQEEEQLLGEERETRRRQELER--QYRKEEE 1085

Query: 537  KFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKF--EEALKEKEEQLTR-VTEVQR 593
              Q E+  L+   EK+    +    + +E+ Q++  +   EE  K + ++L R   E + 
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145

Query: 594  LQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDI 653
            +Q ++     EE +++     E+ Y E +E++++ E  L R +  + +Q +E  ++ E+ 
Sbjct: 1146 VQQEEEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLREEQEKRRQERERQYREEEE 1204

Query: 654  RQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQ 713
             QR +++    +   E +++ L  Q   EK++ VRD++   +  E        E   Q++
Sbjct: 1205 LQRQKRK---QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN-------EQFRQLE 1254

Query: 714  EFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKL 773
            + + RD Q   D++   H L E+      Q +         RE+E++R  +       + 
Sbjct: 1255 DSQLRDRQSQQDLQ---HLLGEQ------QERD--------REQERRRWQQRDRHFPEEE 1297

Query: 774  KAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKE 833
            + E E+ K   ++   ++ E  L +   + K+  +E  +K  +  Q++           +
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLL-----------Q 1346

Query: 834  ENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKL--QH 891
            E  +Q L    R Q+  +KF +E+   +R  +Q  K L++E   R  +    E+K   + 
Sbjct: 1347 EREEQPL----RRQERDRKFREEE---LRHQEQGRKFLEEEQRLRRQE---RERKFLKEE 1396

Query: 892  KELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTY 951
            ++L  QE+   +RQ+ + K +       RQE +      + QV   ++    L+EE    
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456

Query: 952  QGR 954
            Q R
Sbjct: 1457 QER 1459



 Score =  122 bits (305), Expect = 2e-27
 Identities = 164/765 (21%), Positives = 334/765 (43%), Gaps = 83/765 (10%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETI 312
            RE++L  K +    +  EE+ + Q++ +   ++  ++   E EE +     ++ E E   
Sbjct: 302  REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361

Query: 313  RKL------EKKVQTLIRDCQVIRE---TKEDQIAELKKICEQS---------------- 347
            ++L      E++ Q L R+ Q+ RE    +E Q+   +++  +                 
Sbjct: 362  QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421

Query: 348  TESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELL--EDTNVRLNKMESEYMAQTQS 405
             + L  + E++ H    E E+ +  L+++  E    L   E+T     +   + + + Q 
Sbjct: 422  EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481

Query: 406  TNHMIKEL-----------EARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQE 454
                 + L           E R QQL  E E    QR K  +E+  L++  +      +E
Sbjct: 482  EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541

Query: 455  VKARRNTLHK-EKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEE-LEQN 512
             + RR  L K E++  +    +  +L + + +    LLK+E      +     EE LEQ 
Sbjct: 542  QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601

Query: 513  VCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIH 572
            + + + +  E E +R+Q+L+ +E + +  +  LK   E++    Q +L + +++ +++  
Sbjct: 602  LKREEVERLEQEERREQRLKREEPEEERRQQLLKS--EEQEERRQQQLRREQQERREQRL 659

Query: 573  KFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQV---------ELNSE------KV 617
            K EE  +  E++L R  E +R + + A+   E+ + ++         +L SE      KV
Sbjct: 660  KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719

Query: 618  YAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK----LEHEQEKT 673
            Y+  ++Q  +        K  R ++  E  WQ E+   R +Q+  + +        +EK+
Sbjct: 720  YSRPRKQEGQRRRQEQEEK--RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777

Query: 674  HLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKL 733
               +Q  + +  L    ER++   E+Q R      E + +E ++R  +   + E ++  L
Sbjct: 778  ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR---EREKELQFL 834

Query: 734  REELINVNSQRKQQLVEL--GLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAE 791
             EE      +R QQL E   GL  ++E++R+  +      + + E E+     ++ H   
Sbjct: 835  EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK----RRRHTLY 890

Query: 792  TEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEE----NSQQQLAAERRLQ 847
             +  L++   K +Q+ +E  ++L +  +     Q      +EE      ++QL  E R +
Sbjct: 891  AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950

Query: 848  DVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEY 907
              RQ+ E + ++  +   +  ++L +E E R  Q R  EKK + +E   QE+   +R+E 
Sbjct: 951  RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER--EKKYREEEELQQEEEQLLREER 1008

Query: 908  ETKLKGLMPASLR-----QELEDTISSLKSQVNFLQKRASILQEE 947
            E + +       R     Q+ E+ +   + +   LQ+R    +EE
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053



 Score =  119 bits (297), Expect = 2e-26
 Identities = 148/710 (20%), Positives = 316/710 (44%), Gaps = 69/710 (9%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKT----LYRSKQHET 308
            R +EL+ + +  E    EE+  L+++ +   ++ LER+  E EEL+     L R +Q + 
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191

Query: 309  EETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQ 368
             +   +  ++ + L R  +  R   EDQ ++LK   E   E+   D +        E  +
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251

Query: 369  EKFDLQ---KQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAE 425
            +  D Q   +Q  +++Q LL +   R  + E     Q        ++LE   Q+     +
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311

Query: 426  NSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYD 485
              + + ++L++E+ E +R  Q T  + +E       L + ++  +   E++ K  + +  
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFRE---EEQLLQEREEQPLRRQERDRKFREEE-- 1366

Query: 486  ADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLR-DQENKFQMEKSH 544
                L  QE      +    +   E+    LK++ Q    +R+QQLR D++ KF+ E+  
Sbjct: 1367 ----LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422

Query: 545  LKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEK-------EEQLTRVTEVQRLQAQ 597
            L    E+     + E    +++ ++K  + E+ L+++       EEQL +  E Q+L  Q
Sbjct: 1423 LSR-QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481

Query: 598  QADAALEEFKRQV------------ELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKE 645
            + D    E ++Q+            EL S++   +  E+ +++     + K L+E+Q   
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541

Query: 646  FLWQLEDIRQRYEQQI-VELKLEHEQEKTHLLQQHNAEKDSL----VRDHEREIENLEKQ 700
               + +  RQ  +++   E +L  E+E+  L +Q    K  L    VR  E+E + +E +
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601

Query: 701  LRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQ 760
             +    E + Q+++ + R             K RE+   +  + +QQL        +E+ 
Sbjct: 1602 QQLRRQEGQQQLRQERDR-------------KFREDEQLLQEREEQQL------HRQERD 1642

Query: 761  RATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQI 820
            R   E E  + + + E ++++ +  +    E ++  E    +L++ E++  +K  +  Q 
Sbjct: 1643 RKFLEEEPQLRRQERE-QQLRHDRDRKFREEEQLLQEGEEQQLRRQERD--RKFREEEQQ 1699

Query: 821  IAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSN 880
            +   +     L+EE   ++   ER+ ++  Q  ++ +++ +R  ++  K+L++E      
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 881  QVRCAEKKLQHKELESQEQITYIRQE-----YETKLKGLMPASLRQELED 925
            + +   ++ + ++   +EQ+   R+E      E+  K      LRQE E+
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE 1809



 Score =  119 bits (297), Expect = 2e-26
 Identities = 149/687 (21%), Positives = 311/687 (45%), Gaps = 74/687 (10%)

Query: 237  LRKSSSFHD-DHFLSRIREKELDMKTKMMEAKFH----EEKLKLQQKHDADVQKILERKN 291
            LR   S  D  H L   +E++ + + +  + +      EE+L+ +++ +A   K  +RK+
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA---KRRDRKS 1314

Query: 292  NEIEELKTLYRSKQHETEETIRKLEKKVQTLI-RDCQVIRETKEDQIAELKKICEQSTES 350
             E ++L    R ++   +ET RK  ++ Q L  R+ Q +R  + D+    +++  Q    
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374

Query: 351  LNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMI 410
               + E++L     E +  K + Q +  E  Q+L +D + +  + E +   Q +      
Sbjct: 1375 KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434

Query: 411  KELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLV 470
            +E + R Q+          + +K ++E+              Q+++  R+   +E++ L+
Sbjct: 1435 EEQQVRRQE----------RERKFLEEE--------------QQLRQERHRKFREEEQLL 1470

Query: 471  NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQ 530
             + E+     Q +   D   L++E  L   +      E E    + +++  E E Q  +Q
Sbjct: 1471 QEREEQQLHRQER---DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527

Query: 531  LRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTE 590
             R  + KF  E+  L+              ++G++  Q +  KF E     EEQL +  E
Sbjct: 1528 QR--QRKFLQEEQQLRR------------QERGQQRRQDRDRKFRE-----EEQLRQERE 1568

Query: 591  VQRLQAQQADAA--LEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLW 648
             Q+L  Q+ D    LEE K + +   E+ + E ++Q+ + E      + LR+++ ++F  
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQ-EQERKFMEDEQQLRRQEGQ----QQLRQERDRKFRE 1623

Query: 649  QLEDIRQRYEQQIVELKLEHE--QEKTHLLQQHNAEKDSLVRDHE-REIENLEKQLRAAN 705
              + +++R EQQ+   + + +  +E+  L +Q   ++    RD + RE E L ++     
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683

Query: 706  MEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATRE 765
            +  + + ++F++ + Q +   E +   L+EE      + +++  E   LR+E +Q   R 
Sbjct: 1684 LRRQERDRKFREEEQQ-LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742

Query: 766  HEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQ 825
             E     L+ E  + + E ++    E +    +   +L+Q  +E   +  +S +   E +
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKF-REEEQLRQEREEQQLRSQESDRKFREEE 1801

Query: 826  TTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCA 885
                 L++E  +QQL  ++R  D + ++E+E+ QL  + +Q ++  +D       Q    
Sbjct: 1802 ----QLRQEREEQQLRPQQR--DGKYRWEEEQLQL-EEQEQRLRQERDRQYRAEEQFATQ 1854

Query: 886  EKKLQHKELESQEQITYIRQEYETKLK 912
            EK  + ++   QE+    RQE E KL+
Sbjct: 1855 EKSRREEQELWQEEEQKRRQERERKLR 1881



 Score =  116 bits (290), Expect = 1e-25
 Identities = 147/720 (20%), Positives = 327/720 (45%), Gaps = 94/720 (13%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETI 312
            R +EL+ + +  E    EE+  L+++ +   ++  ER+  E EEL       Q E E+ +
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL-------QQEEEQLL 1124

Query: 313  RKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFD 372
            R+  +K +         R+  E Q  E +++ ++  + L  + EK+    +    +E+ +
Sbjct: 1125 REEREKRR---------RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175

Query: 373  LQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTG-----EAENS 427
            LQ+   E  Q L E+   R  + E +Y  + +      K+      Q +      E E  
Sbjct: 1176 LQQ---EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232

Query: 428  NLQRQKLIQEKA-ELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTK--Y 484
            N  R   +  K  E E+  Q+  S+L++ +++++  H   +    D EQ  +  Q +  +
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292

Query: 485  DADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSH 544
              +   L++E    A +     +E        ++QL   E + K++ ++ + KF+ E+  
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQE--------EKQLLREEREEKRRRQETDRKFREEEQL 1344

Query: 545  LKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALK--EKEEQLTRVTEVQRLQAQQADAA 602
            L+   E++   L+ + ++ ++  ++++   E+  K  E+E++L R    ++   ++    
Sbjct: 1345 LQ---EREEQPLRRQ-ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400

Query: 603  LEEFKRQVELNSEKVYAEMKEQMEKVEADLT----RSKSLREKQSKEFLWQLEDIRQ-RY 657
             +E ++Q+  + ++ + E ++Q+ + E D        +  R+++ ++FL + + +RQ R+
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460

Query: 658  EQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKK 717
             +   E +L  E+E+  L   H  E+D    + E+++   E+  +    E  +Q  E K 
Sbjct: 1461 RKFREEEQLLQEREEQQL---HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK- 1516

Query: 718  RDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAES 777
                   + E Q+H+ + +   +  +++ +  E G  R +++ R  RE E    +L+ E 
Sbjct: 1517 -----FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE----QLRQER 1567

Query: 778  EKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ 837
            E+ ++  +     E +        K+++ E+E  +K  +  Q           L+ +  Q
Sbjct: 1568 EEQQLSRQ-----ERDRKFRLEEQKVRRQEQE--RKFMEDEQ----------QLRRQEGQ 1610

Query: 838  QQLAAER--RLQDVRQKFEDEKKQLIRDNDQAIKVLQDE----LENRSNQVRC-AEKKLQ 890
            QQL  ER  + ++  Q  ++ ++Q +   ++  K L++E     + R  Q+R   ++K +
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670

Query: 891  HKE--LESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEEL 948
             +E  L+  E+    RQE + K +         E E  +   + +  FLQ+   + ++EL
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFR---------EEEQQLRRQERERKFLQEEQQLRRQEL 1721



 Score =  114 bits (286), Expect = 3e-25
 Identities = 157/770 (20%), Positives = 318/770 (41%), Gaps = 94/770 (12%)

Query: 254  EKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIR 313
            E E + + ++++++  EE+ + Q + +   ++    K  E EE       ++HE E   +
Sbjct: 624  EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683

Query: 314  KLEKKVQTLIRD----------CQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAV 363
            +L ++ Q   R+           Q+  E    Q     +  +Q  +    + E+K     
Sbjct: 684  ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743

Query: 364  AEM---EQEKFDLQKQHTENIQELL-----EDTNVRLNKMESEYMAQTQSTNHMIK--EL 413
            +E+   E+E+   Q+Q  E  ++       E+ + R  +  S      +     ++  E 
Sbjct: 744  SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803

Query: 414  EARVQQLTGEAENSNLQRQKLIQEKAEL------------ERCYQITCSE--LQEVKARR 459
            + R Q+   E E    +R++  + + EL            ER  Q+   E  LQE + RR
Sbjct: 804  QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863

Query: 460  NTLHKEKDH-----LVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVC 514
             +  + +D      L  + ++    L  K      L K++  L   +     EE E+   
Sbjct: 864  RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR 923

Query: 515  QLKQ-------QLQESELQRKQQLRDQENKFQMEKSHLKH--IYEKKAHDLQSELDKGKE 565
            Q ++       QLQ+ E Q  ++ R++  + + E+ + K   + +K+   L  E +K + 
Sbjct: 924  QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR 983

Query: 566  DTQKKIHKFEEALKEKEEQLTRVTEVQR--------------LQAQQADAALEEFKRQVE 611
              ++K ++ EE L+++EEQL R    +R              LQ ++     EE +++  
Sbjct: 984  QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL 1043

Query: 612  LNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQE 671
               E+ Y E +E  ++ E  L   +  R +Q  E  ++ E+  Q+ E+Q+  L+ E E+ 
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL--LREEPEKR 1101

Query: 672  KTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVH 731
            +    ++   E++ L ++ E+ +    ++ R   +E + + +E  +++ + +   E +  
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161

Query: 732  KLREELINVNSQRKQQLVELGLLREEE------KQRATREHEIV---VNKLKAESEKMKI 782
            + +E       + + Q  E  LLREE+      ++R  RE E +     K +   E  + 
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221

Query: 783  ELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAA 842
            +LK     E E  +       K  E E  ++L  S     + Q  +  L  E  ++    
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281

Query: 843  ERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITY 902
            ERR    R +   E++QL R+                      +K+ + ++ +SQE+   
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREE---------------------QKEAKRRDRKSQEEKQL 1320

Query: 903  IRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
            +R+E E K +        +E E  +   + Q    Q+R    +EE   +Q
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370



 Score =  111 bits (277), Expect = 4e-24
 Identities = 135/647 (20%), Positives = 291/647 (44%), Gaps = 49/647 (7%)

Query: 288 ERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDC-QVIRETKEDQIAELKKICEQ 346
           E K    +  ++L + ++ E ++  R+ E + + L  +  Q  R+ +++Q  EL +  EQ
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQ--RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154

Query: 347 STESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQST 406
           S +      +++L     +   E+   Q+Q  +  +E       R  + E     +   T
Sbjct: 155 SEK------QERLEQRDRQRRDEELWRQRQEWQEREE-------RRAEEEQLQSCKGHET 201

Query: 407 NHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEK 466
                E + R ++L         ++Q+  Q +   +R +Q    E +E + R   L KE+
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQ--QRRERQDRVFQE--EEEKEWRKRETVLRKEE 257

Query: 467 DHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQ 526
           + L  +  Q  + LQ          ++E  L   +   +  E ++   Q ++  +E +L+
Sbjct: 258 EKLQEEEPQRQRELQ----------EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307

Query: 527 RKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLT 586
           RKQ+  ++  + Q E+   +   E++    + +L + +E+ +++  + E+  + +E+QL 
Sbjct: 308 RKQE--EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365

Query: 587 RVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEF 646
           R  E +R + Q      ++ +R+ +L  E+     +EQ  + E  L R + LR +Q    
Sbjct: 366 REQEEERREQQLRRE--QQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQ--- 418

Query: 647 LWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLE--KQLRAA 704
           L + + +R+  E++  E K E E+ +  L ++    +D L R+ E E    E  KQ    
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 705 NMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQR--KQQLVELGLLREEEKQRA 762
           + E E + +  K  + +     E +  +LR E      QR  +Q+  E    R   +Q+ 
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538

Query: 763 TREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA 822
            RE E    +L    E+ ++E ++          E+ +  LK+ E+   Q+L +  +   
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE--E 596

Query: 823 ELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQV 882
            L+  +   + E  +Q+   E+RL+  R++ E+E++Q +  +++  +  Q +L     + 
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLK--REEPEEERRQQLLKSEEQEERRQQQLRREQQER 654

Query: 883 RCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISS 929
           R  E++L+ +E E + +    R+  E + +  +    +++  + I S
Sbjct: 655 R--EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 115/485 (23%), Positives = 218/485 (44%), Gaps = 60/485 (12%)

Query: 492 KQEHALSASKASSMIEE-LEQNVCQLKQQ---LQESELQRKQQLRDQENKFQMEKSHLKH 547
           +QE  L+  +  S  +E LEQ   Q + +    Q  E Q +++ R +E + Q  K H   
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETE 202

Query: 548 IYEKKAHDLQSEL----DKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAAL 603
            +  +    + EL     KG+E+ Q++  + ++ + ++EE+         L+ ++     
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262

Query: 604 EEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE 663
           EE +RQ EL  E+      EQ+ K+E    R +   E+Q ++ L + + +R++ E++  E
Sbjct: 263 EEPQRQRELQEEE------EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316

Query: 664 LKLEHEQEKTHLLQQHNAEKDSLVRDHE----------REIENLEKQLRAANMEHENQIQ 713
            + E  +++    QQ    +  L R+ E          +E E  E+QLR    E   + Q
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376

Query: 714 EFKKRDAQVIADMEAQVHKLREELINVNSQ--------RKQQLV-ELGLLREEEKQRATR 764
             +++  +    +  +    RE+ +    Q        R+QQL  E  L RE+E++R  +
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436

Query: 765 EHEIV--VNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA 822
           +HE      +LK E E+ +  LK+    E     E+   +LK+ ++E             
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERH-EQERRKQQLKRDQEE------------- 482

Query: 823 ELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQV 882
           E +     L+EE  ++Q   ERR Q +R++ E+ ++Q ++         + E E R  Q 
Sbjct: 483 ERRERWLKLEEEERREQ--QERREQQLRREQEERREQRLK---------RQEEEERLQQR 531

Query: 883 RCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRAS 942
             +E++L+ ++ E +EQ+    +E   + +       R++ E     LK +    Q+R  
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591

Query: 943 ILQEE 947
             QEE
Sbjct: 592 REQEE 596



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 113/514 (21%), Positives = 227/514 (44%), Gaps = 80/514 (15%)

Query: 251  RIREKELDMKTKMMEAKFHEEKLKLQQ----KHDADVQKILERKNNEI------------ 294
            + RE+E  ++ +  E KF EE+ +L+Q    K   + Q + ER+  ++            
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490

Query: 295  ------EELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQST 348
                  +E    +R ++  ++E  RK  ++ Q L R  +  +  +E+Q  +L++  ++  
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ--QLRR--QERG 1546

Query: 349  ESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQEL-LEDTNVRLNKMESEYMAQTQSTN 407
            +    D ++K      ++ QE+ + Q    E  ++  LE+  VR  + E ++M   Q   
Sbjct: 1547 QQRRQDRDRKFREE-EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605

Query: 408  HMIKELEARVQ---------QLTGEAENSNLQRQ----KLIQEKAELERCYQITCSELQE 454
                + + R +         QL  E E   L RQ    K ++E+ +L R           
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR----------- 1654

Query: 455  VKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVC 514
             + R   L  ++D    + EQ   LLQ   +  +   +++      +     +E E+   
Sbjct: 1655 -QEREQQLRHDRDRKFREEEQ---LLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710

Query: 515  QLKQQLQESELQRK----QQLRDQENKFQMEKSH-LKHIYEKKAHDLQSELDKGKEDTQK 569
            Q +QQL+  EL+RK    +QLR +  + Q+ +    + I E++   L+ E ++ +   Q+
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE--QLRPEREEQQLRRQE 1768

Query: 570  KIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVE 629
            +  KF E     EEQL +  E Q+L++Q++D    +F+ + +L  E+   +++ Q     
Sbjct: 1769 RDRKFRE-----EEQLRQEREEQQLRSQESD---RKFREEEQLRQEREEQQLRPQQRD-- 1818

Query: 630  ADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRD 689
                  K   E++  +   Q + +RQ  ++Q    +    QEK+   +Q   +++   R 
Sbjct: 1819 -----GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR 1873

Query: 690  HEREIENLEKQLRAANMEHE--NQIQEFKKRDAQ 721
             ERE +  E+ +R    E +   Q+ E K ++ +
Sbjct: 1874 QERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 128/578 (22%), Positives = 254/578 (43%), Gaps = 75/578 (12%)

Query: 243  FHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYR 302
            F ++  L + RE++  ++ +  + KF EE+L+    H    +K LE    E + L+   R
Sbjct: 1338 FREEEQLLQEREEQ-PLRRQERDRKFREEELR----HQEQGRKFLE----EEQRLRRQER 1388

Query: 303  SKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAEL---KKICEQSTESLNNDWEKKL 359
             ++   EE   + +++ Q L +D       +E Q++     +K  E+  +    + E+K 
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448

Query: 360  HNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNK----MESEYMAQTQSTNHMIKELEA 415
                 ++ QE+    ++  + +QE  E    R  +    +E E   + Q  +   +E E 
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508

Query: 416  RVQQ-----LTGEAENSNLQRQ-KLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHL 469
            R Q+     L  E +    QRQ K +QE+ +L R         Q+ +  R+   +E++ L
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ-----ERGQQRRQDRDRKFREEEQL 1563

Query: 470  VNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQ 529
              + E+  +L + + D    L +Q+      +   M +E +    + +QQL++   +R +
Sbjct: 1564 RQEREEQ-QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ---ERDR 1619

Query: 530  QLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVT 589
            + R+ E   Q  +    H  E+    L+ E    +++ ++++    +    +EEQL +  
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679

Query: 590  EVQRLQAQQADAALEEFKRQVELNS-EKVYAEMKEQM--EKVEADLTRSKSLREKQSKEF 646
            E Q+L+ Q+ D    E ++Q+     E+ + + ++Q+  +++E      + LR++  +E 
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739

Query: 647  LWQLEDIR----------QRYEQQI----------VELKLEHEQEKTHLLQQHNAEK--- 683
            L + E  R          +R EQQ+           E +L  E+E+  L  Q +  K   
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799

Query: 684  DSLVRDHEREIENL------------EKQLRAANMEHENQIQEFKKRDAQVIADMEAQVH 731
            +  +R  ERE + L            E+QL+    E E ++++ + R  +       Q  
Sbjct: 1800 EEQLRQ-EREEQQLRPQQRDGKYRWEEEQLQLE--EQEQRLRQERDRQYRAEEQFATQEK 1856

Query: 732  KLRE--ELINVNSQRKQQLVELGLLREEEKQRATREHE 767
              RE  EL     Q+++Q  E   LREE  +R  +E +
Sbjct: 1857 SRREEQELWQEEEQKRRQERE-RKLREEHIRRQQKEEQ 1893



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 57/240 (23%), Positives = 103/240 (42%), Gaps = 46/240 (19%)

Query: 689 DHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQL 748
           D E+      K+    +   E   + F+ RD Q           L EE      QR++Q 
Sbjct: 96  DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQ-----------LEEE----PGQRRRQ- 139

Query: 749 VELGLLREEEKQRATREHEIVVNKLKAESEKM-KIELKKTHAAETEMTLEKANSKLKQIE 807
                 + +E++R   E E        +SEK  ++E +     + E+       + +Q  
Sbjct: 140 ------KRQEQERELAEGE-------EQSEKQERLEQRDRQRRDEELW------RQRQEW 180

Query: 808 KEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQA 867
           +E  ++ A+  Q    LQ+      EE   ++    R L ++R+K  +EK+Q  R+    
Sbjct: 181 QEREERRAEEEQ----LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR 236

Query: 868 IKVLQDELE--NRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELED 925
           +   ++E E   R   +R  E+KLQ +E + Q ++    QE E +L+ L    LR+E ++
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL----QEEEEQLRKLERQELRRERQE 292


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  129 bits (323), Expect = 2e-29
 Identities = 160/775 (20%), Positives = 351/775 (45%), Gaps = 103/775 (13%)

Query: 258  DMKTKMMEAKFHEEKLKLQ-QKHDADVQKILER-------KNNEIEELKTLY-------- 301
            D++ ++ E +   ++LKLQ  K + ++Q  L R       KNN ++ ++ L         
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125

Query: 302  -----RSKQHETEETIRKLEKKVQTLIRDC----------QVIRETKEDQIAELKKICEQ 346
                 ++ +++ E+  R L ++++ L  +           Q +R  +E ++AELKK  E+
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185

Query: 347  ST---ESLNNDWEKKLHNAVAEMEQ--EKFDLQKQHTENIQELLEDTNVRLNKMESEYMA 401
             T   E+   D  ++   A+ E+ +  E+    K + E  ++ LE  N  L   E + + 
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL-ACEVKVLQ 1244

Query: 402  QTQS-TNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRN 460
            Q ++ + H  K+L+A+VQ+L  +    +  R +L ++ ++L+       + L+E + +  
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304

Query: 461  TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQL 520
               K+   L +  +   +LLQ +    +NL  +   L   K S  ++E ++   + ++ L
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS--LQEQQEEEEEARKNL 1362

Query: 521  QESELQRKQQLRDQENKFQMEKSHLKHIYE------KKAHDLQSELDKGKEDTQKKIHKF 574
            ++  L  + QL D + K   +   ++ + E      K A  L   L++ K     K+ K 
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE-KALAYDKLEKT 1421

Query: 575  EEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
            +  L+++ + LT   + QR  A   +   ++F  Q+    + + A   E+ ++ EA+  R
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD-QLLAEEKSISARYAEERDRAEAE-AR 1479

Query: 635  SKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQ---------EKTHLLQQHNAEKDS 685
             K  +       L +  + ++ +E+Q  +L+ + E          +  H L++     + 
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539

Query: 686  LVRDHEREIENLEKQLRA---------ANME------------HENQIQEFKKRDAQVIA 724
             V +   ++E LE +L+A          NM+             + Q +E K+   + + 
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599

Query: 725  DMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIV--VNKLKAESEKMKI 782
            ++EA++   R++     + +K+  ++L  L  + +       E++  + KL+A+ +  + 
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659

Query: 783  ELKKTHAAETEMTLEKANS--KLKQIEKEYTQ---KLAKSSQI----------IAELQTT 827
            EL++  A+  E+  +   S  KLK +E E  Q   +LA S +           +A+  T 
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719

Query: 828  ISSLKEENSQQQLAAERRLQDVRQKFEDEKK--QLIRDNDQAIKVLQDELENRSNQVRCA 885
             +S K     ++   E R+  + ++ E+E+   +L+ D  +   +  D L    N    A
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTL----NAELAA 1775

Query: 886  EKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKR 940
            E+    K   +++Q+    +E + KL+ L   +++ + + TIS+L++++  L+++
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQEL-EGAVKSKFKATISALEAKIGQLEEQ 1829



 Score =  123 bits (308), Expect = 9e-28
 Identities = 153/705 (21%), Positives = 315/705 (44%), Gaps = 69/705 (9%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQ------QKHDADVQKILERKNNEIEELKTLYRSKQH 306
            +++EL+     +E++  EE+ + Q      +K  A +Q  LE + +E E  +   + ++ 
Sbjct: 916  KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD-LEEQLDEEEGARQKLQLEKV 974

Query: 307  ETEETIRKLEKKVQTLI-RDCQVIRETK--EDQIAELKKICEQSTESLNN--DWEKKLHN 361
              E  I+K+E+++  L  ++ + I+E K  ED+IAE      +  E   N      K   
Sbjct: 975  TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034

Query: 362  AVAEMEQ--EKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQ 419
             ++++E+  +K +  +Q  E  +  L+     L    +E  AQ       + + E  +Q 
Sbjct: 1035 MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQG 1094

Query: 420  LTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKL 479
                 ++  L +   ++   EL+        + +  KA RN   K+K     D  + ++ 
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK----RDLSEELEA 1150

Query: 480  LQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQ 539
            L+T+ +  ++    +  L   +        EQ V +LK+ L+E     + Q++D   +  
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKR--------EQEVAELKKALEEETKNHEAQIQDMRQRHA 1202

Query: 540  MEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQA 599
                 L    E +A   ++ L+K K+  +       + L  + + L +V      + ++ 
Sbjct: 1203 TALEELSEQLE-QAKRFKANLEKNKQGLETD----NKELACEVKVLQQVKAESEHKRKKL 1257

Query: 600  DAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR--QRY 657
            DA ++E   +V    +++  E+ E+  K++ +L    +L E+  K+ +   +D    +  
Sbjct: 1258 DAQVQELHAKVS-EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316

Query: 658  EQQIVELKLEHEQEKTHL---LQQHNAEKDSLVRDHEREIE---NLEKQLRAANMEHENQ 711
             Q   EL  E  ++K +L   ++Q   EK+SL    E E E   NLEKQ+ A     ++Q
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL----QSQ 1372

Query: 712  IQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVN 771
            + + KK+    +  +E+ + + +++L+       Q+L        EEK  A  + E   N
Sbjct: 1373 LADTKKKVDDDLGTIES-LEEAKKKLLKDAEALSQRL--------EEKALAYDKLEKTKN 1423

Query: 772  KLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSL 831
            +L+ E + + ++L   H  +    LEK   K  Q+  E     A+     AE +    + 
Sbjct: 1424 RLQQELDDLTVDL--DHQRQVASNLEKKQKKFDQLLAEEKSISAR----YAEERDRAEAE 1477

Query: 832  KEENSQQQLAAERRLQ---DVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK 888
              E   + L+  R L+   + +++FE + KQL  D +  +   +D++    +++  +++ 
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS-SKDDVGKNVHELEKSKRA 1536

Query: 889  LQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQ 933
            L+ +  E + Q+    +E E +L+    A LR  LE  + ++K+Q
Sbjct: 1537 LEQQVEEMRTQL----EELEDELQATEDAKLR--LEVNMQAMKAQ 1575



 Score =  122 bits (305), Expect = 2e-27
 Identities = 139/678 (20%), Positives = 302/678 (44%), Gaps = 76/678 (11%)

Query: 255  KELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRK 314
            KEL  + K+++    E + K ++K DA VQ+ L  K +E + L+     K  + +  +  
Sbjct: 1234 KELACEVKVLQQVKAESEHK-RKKLDAQVQE-LHAKVSEGDRLRVELAEKASKLQNEL-- 1289

Query: 315  LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLH--NAVAEMEQEKFD 372
                V TL+ + +          A L+   + + E L  +  +KL+  + + ++E+EK  
Sbjct: 1290 --DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347

Query: 373  LQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQ 432
            LQ+Q  E      E+    L K       Q  +    + + + +V    G  E+    ++
Sbjct: 1348 LQEQQEEE-----EEARKNLEK-------QVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 433  KLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ------NMKLLQTKYDA 486
            KL+++   L +  +       +++  +N L +E D L  D +       N++  Q K+D 
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD- 1454

Query: 487  DINLLKQEHALSA------SKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
               LL +E ++SA       +A +   E E     L + L+E+ L+ K++   Q  + + 
Sbjct: 1455 --QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA-LEAKEEFERQNKQLRA 1511

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRV-TEVQRLQAQQA 599
            +                 +L   K+D  K +H+ E++ +  E+Q+  + T+++ L+ +  
Sbjct: 1512 D---------------MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556

Query: 600  DAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQ 659
              A E+ K ++E+N + + A+ +  ++  +      K L  KQ +E   +LED R++   
Sbjct: 1557 --ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614

Query: 660  QI-----VELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQE 714
             +     +E+ L+  + +     +   E    +R  + ++++ +++L  A    +    +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674

Query: 715  FKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
             K+ + + +  +EA++ +L+EEL +    R+    E   L +E    A+ +  ++     
Sbjct: 1675 SKESEKK-LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALL----- 1728

Query: 775  AESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSL-KE 833
               EK ++E +    A+ E  LE+  S ++ +   + +   +   + AEL    S+  K 
Sbjct: 1729 --DEKRRLEAR---IAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKS 1783

Query: 834  ENSQQQLAAERR-----LQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK 888
            +N++QQL  + +     LQ++    + + K  I   +  I  L+++LE  + +   A K 
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843

Query: 889  LQHKELESQEQITYIRQE 906
            ++  E + +E    +  E
Sbjct: 1844 VRRTEKKLKEIFMQVEDE 1861



 Score =  105 bits (262), Expect = 2e-22
 Identities = 120/624 (19%), Positives = 284/624 (45%), Gaps = 82/624 (13%)

Query: 255  KELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRK 314
            ++L++ +++ + +  +  L+ QQ+ + + +K LE++   ++      + K  +   TI  
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389

Query: 315  LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEK---F 371
            LE+  + L++D + + +  E++     K+     E   N  +++L +   +++ ++    
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKL-----EKTKNRLQQELDDLTVDLDHQRQVAS 1444

Query: 372  DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELE-ARVQQLTGEA-ENSNL 429
            +L+K+  +  Q L E+ ++     E    A+ ++     K L  AR  +   EA E    
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFER 1504

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADIN 489
            Q ++L  +  +L          + E++  +  L ++ + +    E+    LQ   DA + 
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564

Query: 490  LLKQEHALSASKASSMIEELEQN-------VCQLKQQLQESELQRKQQLRDQENKFQMEK 542
            L     A+ A     +    EQN       + Q+++   E E +RKQ+     +K +ME 
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI 1624

Query: 543  SHLKHIYEKKAHDLQSELD---KGKEDTQKKIHKFEEALKEKEEQLTRVTEVQR---LQA 596
                        DL+++++   K +++  K++ K +  +K+ + +L      +     Q+
Sbjct: 1625 D---------LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS 1675

Query: 597  QQADAALEEFKRQV-----EL-NSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQL 650
            ++++  L+  + ++     EL +SE+     +++ +++  ++T S S +          L
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA--------L 1727

Query: 651  EDIRQRYEQQIVELKLEHEQEKTHL------LQQHNAEKDSL------VRDHEREIENLE 698
             D ++R E +I +L+ E E+E++++       ++   + D+L       R   ++ +N  
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787

Query: 699  KQLRAANMEHENQIQEF----KKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLL 754
            +QL   N E + ++QE     K +    I+ +EA++ +L E+L                 
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQL----------------- 1830

Query: 755  REEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEK---EYT 811
             +E K+RA     +   + K +   M++E ++ HA + +  +EKAN+++KQ+++   E  
Sbjct: 1831 EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890

Query: 812  QKLAKSSQIIAELQTTISSLKEEN 835
            ++  +++    +LQ  +    E N
Sbjct: 1891 EEATRANASRRKLQRELDDATEAN 1914



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 132/608 (21%), Positives = 259/608 (42%), Gaps = 107/608 (17%)

Query: 418  QQLTGEAENSNLQRQKLIQEKAELERCYQ----------ITCSELQ----------EVKA 457
            ++L  + E     ++K  + + ELE   +          I   +LQ          E++A
Sbjct: 852  EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRA 911

Query: 458  RRNTLHKEKDHLVNDY--------EQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL 509
            R     +E + +++D         E+N  L   K     ++   E  L   + +    +L
Sbjct: 912  RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL 971

Query: 510  EQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGK----- 564
            E+   + K +  E E+     L DQ +KF  EK  ++    + +  L  E +K K     
Sbjct: 972  EKVTAEAKIKKMEEEI---LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028

Query: 565  -----------EDTQKKIHKFEEALKEKEEQLTRVT-----EVQRLQAQQADAALEEFKR 608
                       E+  KK  K  + L++ + +L   T     ++  LQAQ  +  L+  K+
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088

Query: 609  QVEL---------------NSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDI 653
            + EL               N+ KV  E++ Q+ +++ D    K+ R K  K    Q  D+
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK----QKRDL 1144

Query: 654  RQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQ 713
             +  E + ++ +LE   + T       A +  L    E+E+  L+K L      HE QIQ
Sbjct: 1145 SE--ELEALKTELEDTLDTT-------AAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195

Query: 714  EFKKRDAQVIADMEAQVHKLREELINVNSQR-------KQQLVELGLLRE--EEKQRATR 764
            + ++R A  + ++  Q+ + +    N+   +       K+   E+ +L++   E +   +
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK 1255

Query: 765  EHEIVVNKLKA---ESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQII 821
            + +  V +L A   E +++++EL +  A++ +  L+  ++ L++ EK+  +    ++ + 
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAE-KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314

Query: 822  AELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQ 881
            ++LQ T   L+EE  Q+   + R    +RQ  E+EK  L    ++     ++  +N   Q
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSR----IRQ-LEEEKNSLQEQQEEE----EEARKNLEKQ 1365

Query: 882  VRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPA-SLRQELEDTISSLKSQVNFLQKR 940
            V   + +L   + +  + +  I    E K K L  A +L Q LE+   +       L+K 
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK----LEKT 1421

Query: 941  ASILQEEL 948
             + LQ+EL
Sbjct: 1422 KNRLQQEL 1429



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 120/536 (22%), Positives = 245/536 (45%), Gaps = 67/536 (12%)

Query: 479  LLQTKYDADINLLKQEHALSASKASSMIE-ELEQNVCQLKQQLQES-----ELQRKQQLR 532
            LLQ     +    K E  L   +  + +E ELE+   + +Q L+E      +LQ + +L 
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903

Query: 533  DQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDT---QKKIHKFEEALKEKEEQLTRVT 589
             +  + +   +  K   E+  HDL+S +++ +E     Q +  K +  +++ EEQL    
Sbjct: 904  AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963

Query: 590  EV-QRLQAQQ--ADAALEEFKRQVEL--NSEKVYAEMKEQMEKVEADLTRSKSLREKQSK 644
               Q+LQ ++  A+A +++ + ++ L  +    + + K+ ME   A+ +   +  E+++K
Sbjct: 964  GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023

Query: 645  EFLWQLEDIRQRYEQQIVEL--KLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLR 702
                 L  IR + E  I +L  +L+ E++    L++   + D    D + +I  L+ Q+ 
Sbjct: 1024 ----NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079

Query: 703  AANMEHENQIQEF-------------KKRDAQVIADMEAQVHKLREELINVNSQRKQQLV 749
               ++   + +E              K    +V+ +++AQ+ +L+E+  +  + R +   
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139

Query: 750  ELGLLREEEKQRATREHEIV-----VNKLKAESEKMKIELKKTHAAET---EMTLEKANS 801
            +   L EE +   T   + +       +L+ + E+   ELKK    ET   E  ++    
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199

Query: 802  KLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAE-RRLQDVRQKFEDEKKQL 860
            +     +E +++L ++ +  A L+     L+ +N  ++LA E + LQ V+ + E ++K+L
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDN--KELACEVKVLQQVKAESEHKRKKL 1257

Query: 861  ----------IRDND-------QAIKVLQDELENRSNQVRCAEKK-----LQHKELESQE 898
                      + + D       +    LQ+EL+N S  +  AEKK          LESQ 
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317

Query: 899  QITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGR 954
            Q T    + ET+ K  + + +RQ LE+  +SL+ Q    ++    L++++   Q +
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQ-LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 51/209 (24%), Positives = 92/209 (44%), Gaps = 40/209 (19%)

Query: 251  RIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIE-ELKTLYRSKQHETE 309
            R R+  L + T  + A+   E+   Q+  +A  Q  LER+N E++ +L+ L  + + + +
Sbjct: 1758 RFRKTTLQVDT--LNAELAAERSAAQKSDNARQQ--LERQNKELKAKLQELEGAVKSKFK 1813

Query: 310  ETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQE 369
             TI  LE K+  L  + Q+ +E KE   A            L    EKKL     ++E E
Sbjct: 1814 ATISALEAKIGQL--EEQLEQEAKERAAAN----------KLVRRTEKKLKEIFMQVEDE 1861

Query: 370  KFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
            +     +H +  +E +E  N R+                  K+L+ ++++   EA  +N 
Sbjct: 1862 R-----RHADQYKEQMEKANARM------------------KQLKRQLEEAEEEATRANA 1898

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKAR 458
             R+KL +E  +     +    E+  +K R
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNR 1927


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  128 bits (322), Expect = 2e-29
 Identities = 183/788 (23%), Positives = 360/788 (45%), Gaps = 124/788 (15%)

Query: 254  EKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHET---EE 310
            E+E++ +    + K  +E  +L++  D D++  L +   E    +   ++   E    +E
Sbjct: 930  EEEINAELTAKKRKLEDECSELKKDID-DLELTLAKVEKEKHATENKVKNLTEELSGLDE 988

Query: 311  TIRKL--EKKV-----QTLIRDCQVIRETKEDQIAELKKICEQSTESLNN--DWEKKLHN 361
            TI KL  EKK      Q  + D Q   E K + + + K   EQ  E L +  + EKKL  
Sbjct: 989  TIAKLTREKKALQEAHQQALDDLQA-EEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLR- 1046

Query: 362  AVAEMEQEKFDLQ---KQHTENIQELLEDT---NVRLNKMESEYMAQTQST--------- 406
               ++E+ K  L+   K   E+I +L  D    + RL K + EY  Q QS          
Sbjct: 1047 --VDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEY-CQLQSKVEDEQTLGL 1103

Query: 407  --NHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNT--- 461
                 IKEL+AR+++L  E E     R K  +++++  R  +     L+E     +T   
Sbjct: 1104 QFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 1163

Query: 462  LHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQ 521
            L+K+++       ++++    +++A +  L+++HA S ++    I+ L++    +KQ+L+
Sbjct: 1164 LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQR----VKQKLE 1219

Query: 522  ESELQRKQQLRDQENKFQM---EKSHLKHIYEK----------KAHDLQ---SELDKGKE 565
            + + + K ++ D  +  +     K++L+ I             K  ++Q   SEL   K 
Sbjct: 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKS 1279

Query: 566  DTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVEL-NSEKVYAEMKEQ 624
              Q +  +    L+EKE  +++++  ++   QQ     EE KRQ+E  N  K       Q
Sbjct: 1280 RLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT----EELKRQLEEENKAKNALAHALQ 1335

Query: 625  MEKVEADLTRSKSLREKQSKEFLW--------QLEDIRQRYEQQIVELKLEHEQEKTHLL 676
              + + DL R +   E++ K  L         ++   R +YE   ++   E E+ K  L 
Sbjct: 1336 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1395

Query: 677  QQH----------NAEKDSLVRDHER---EIENLEKQLRAANM----------EHENQIQ 713
            Q+           NA+  SL +  +R   E+E+L   +  AN             +  + 
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455

Query: 714  EFKKRDAQVIADMEAQVHKLRE---ELINVNSQRKQQLVELGLLREE----EKQRATREH 766
            E+K +  +  A++EA + + R    EL  + +  ++ L +L  ++ E    E++ A    
Sbjct: 1456 EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE 1515

Query: 767  EIVVNKL---KAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAE 823
            +I  N     + E  + +IEL+K   A+ ++ LE+A + L+  E +  +   + +Q+ +E
Sbjct: 1516 QIAENGKTIHELEKSRKQIELEK---ADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572

Query: 824  LQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVR 883
            +   I+   EE  Q +   +R ++ ++   + E    +R  ++AI+ L+ ++E   N++ 
Sbjct: 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE----VRSRNEAIR-LKKKMEGDLNEI- 1626

Query: 884  CAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTI---SSLKSQVNFLQKR 940
              E +L H   ++ E + ++R   + +LK       +  L+D +     LK Q+  +++R
Sbjct: 1627 --EIQLSHANRQAAETLKHLRS-VQGQLK-----DTQLHLDDALRGQEDLKEQLAIVERR 1678

Query: 941  ASILQEEL 948
            A++LQ E+
Sbjct: 1679 ANLLQAEV 1686



 Score =  120 bits (300), Expect = 8e-27
 Identities = 183/900 (20%), Positives = 382/900 (42%), Gaps = 132/900 (14%)

Query: 126  ELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHRE---DGQN 182
            +++  E  L +  K     +N +     ++   ++   KL     +L   H++   D Q 
Sbjct: 954  DIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQA 1013

Query: 183  ITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSS 242
               K+  +   KS +     D+E+ L             ++K + V L   K  L     
Sbjct: 1014 EEDKVNSLNKTKSKLEQQVEDLESSLE------------QEKKLRVDLERNKRKLEGDLK 1061

Query: 243  FHDDHFLSRIREKE-LDMKTKMMEAKF--------HEEKLKLQ-QKHDADVQKILERKNN 292
               +  L    +K+ LD + K  + ++         E+ L LQ QK   ++Q  +E    
Sbjct: 1062 LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEE 1121

Query: 293  EIEELKTLYRSKQHETEETIRKLEKKVQTL-----IRDCQV-IRETKEDQIAELKKICEQ 346
            EIE  +      + +  +  R+LE+  + L     +   Q+ + + +E +  +L++  E+
Sbjct: 1122 EIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEE 1181

Query: 347  ST---ESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQT 403
            +T   E++     KK  ++VAE+ ++  +LQ+   + +++   +  + ++ + S   + +
Sbjct: 1182 ATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK-QKLEKEKSEFKLEIDDLSSSMESVS 1240

Query: 404  QSTNHMIK---ELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRN 460
            +S  ++ K    LE ++ +  G+ E       +L  +K+ L+        +L+E ++  +
Sbjct: 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300

Query: 461  TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQL 520
             L + K       E+  + L+ +  A   L    HAL +S+            C L ++ 
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALA---HALQSSRHD----------CDLLREQ 1347

Query: 521  QESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKE 580
             E E + K +L+   +K   E +  +  YE  A     EL++ K+   +++   EE ++ 
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

Query: 581  KEEQLTRVTEV-QRLQAQQAD------------AALEEFKRQVELNSEKVYAEMKEQMEK 627
               +   + +  QRLQ +  D            AAL++ +R    N +KV AE K + E+
Sbjct: 1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR----NFDKVLAEWKTKCEE 1463

Query: 628  VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLV 687
             +A+L  S     K+S+    +L  ++  YE+ + +L+    + K   L+Q  A+    +
Sbjct: 1464 SQAELEASL----KESRSLSTELFKLKNAYEEALDQLETVKRENKN--LEQEIADLTEQI 1517

Query: 688  RDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQ 747
             ++ + I  LEK  +   +E  + IQ   +     +   EA++ +++ EL  V S+  ++
Sbjct: 1518 AENGKTIHELEKSRKQIELEKAD-IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRK 1576

Query: 748  LVELGLLREEEKQRATREHEIVVN-------------------KLKAESEKMKIELKKTH 788
            + E    ++EE ++  R ++  V                    K K E +  +IE++ +H
Sbjct: 1577 IAE----KDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSH 1632

Query: 789  A----AETEMTLEKANSKLKQIE----------KEYTQKLAKSSQIIAELQTTISSLK-- 832
            A    AET   L     +LK  +          ++  ++LA   +    LQ  +  L+  
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRAT 1692

Query: 833  -EENSQQQLAAERRLQDVRQKFE----------DEKKQLIRDNDQAIKVLQDELENRSNQ 881
             E+  + +  AE+ L D  ++ +            KK+L  D  Q    LQ E+E+ S  
Sbjct: 1693 LEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQ----LQSEVEDASRD 1748

Query: 882  VRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRA 941
             R AE+K +    ++      +++E +T         +++ LE T+  L+ +++  ++ A
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEELKKEQDTSAH---LERMKKNLEQTVKDLQHRLDEAEQLA 1805



 Score =  114 bits (285), Expect = 4e-25
 Identities = 144/710 (20%), Positives = 299/710 (42%), Gaps = 83/710 (11%)

Query: 216  ENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKM---MEAKFHE-- 270
            E  R L +K   VS    + S  K +       L R  E+E   K  +   +++  H+  
Sbjct: 1287 ELSRQLEEKESIVS----QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342

Query: 271  ---EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQ 327
               E+ + +Q+  A++Q+ L + N+E+ + +T Y +   +  E + + +KK+   ++D  
Sbjct: 1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD-- 1400

Query: 328  VIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLED 387
                  E+Q+  +   C                   A +E+ K  LQ +    +++L+ D
Sbjct: 1401 -----SEEQVEAVNAKC-------------------ASLEKTKQRLQGE----VEDLMVD 1432

Query: 388  TNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQI 447
               R N + +    + ++ + ++ E + + ++   E E S  + + L  E  +L+  Y+ 
Sbjct: 1433 VE-RANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEE 1491

Query: 448  TCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQ--TKYDADINLLKQEHALSASKASSM 505
               +L+ VK     L +E   L     +N K +    K    I L K +  L+  +A + 
Sbjct: 1492 ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAA 1551

Query: 506  IEELEQNVCQLKQQLQE--SELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKG 563
            +E  E  + +++ +L +  SE+ RK   +D+E +       LK  Y++    +QS LD  
Sbjct: 1552 LEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE------QLKRNYQRTVETMQSALDAE 1605

Query: 564  KEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKE 623
                 + I      LK+K E      E+Q   A +  A   +  R V+   +     + +
Sbjct: 1606 VRSRNEAIR-----LKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDD 1660

Query: 624  QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQ-----QIVELKLEHEQEKTHLLQQ 678
             +   E DL    ++ E+++     ++E++R   EQ     ++ E +L    E+  LL  
Sbjct: 1661 ALRGQE-DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHT 1719

Query: 679  HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKK--RDAQVIADMEAQVHKLREE 736
             N       +  E ++  L+ ++  A+ +  N  ++ KK   DA ++A+   +       
Sbjct: 1720 QNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1779

Query: 737  LINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMT- 795
            L  +    +Q + +L    +E +Q A +  +  + KL+    +++ EL+      TE   
Sbjct: 1780 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVK 1839

Query: 796  -LEKANSKLKQI---EKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQ 851
             L K   ++K++    +E  + + +   ++ +LQ  + S K +  +    A   L     
Sbjct: 1840 GLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL----T 1895

Query: 852  KFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKEL---ESQE 898
            KF   + +L    ++A     D  E++ N++R   +      +   ES+E
Sbjct: 1896 KFRKAQHELEEAEERA-----DIAESQVNKLRAKTRDFTSSRMVVHESEE 1940



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 101/452 (22%), Positives = 203/452 (44%), Gaps = 75/452 (16%)

Query: 515  QLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSE---LDKGKEDTQKKI 571
            ++K  L+ +E ++  ++   + +FQ  K  L    E K  +L+ +   L + K D Q ++
Sbjct: 836  KIKPLLKSAETEK--EMATMKEEFQKTKDELAK-SEAKRKELEEKLVTLVQEKNDLQLQV 892

Query: 572  HKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEAD 631
                E L + EE+  ++ +                K Q+E   ++V  E  E  E++ A+
Sbjct: 893  QAESENLLDAEERCDQLIKA---------------KFQLEAKIKEV-TERAEDEEEINAE 936

Query: 632  LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE 691
            LT  K   E +  E    ++D+      ++   K+E E+  T          ++ V++  
Sbjct: 937  LTAKKRKLEDECSELKKDIDDL------ELTLAKVEKEKHAT----------ENKVKNLT 980

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVEL 751
             E+  L++ +     E +  +QE  +   Q + D++A+  K+   L    S+ +QQ+ +L
Sbjct: 981  EELSGLDETIAKLTRE-KKALQEAHQ---QALDDLQAEEDKV-NSLNKTKSKLEQQVEDL 1035

Query: 752  -GLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEY 810
               L +E+K R   E     NK K E +   ++L +    + E   ++ + +LK+ + EY
Sbjct: 1036 ESSLEQEKKLRVDLER----NKRKLEGD---LKLAQESILDLENDKQQLDERLKKKDFEY 1088

Query: 811  TQKLAK----------SSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQL 860
             Q  +K            + I ELQ  I  L+EE     + AER     R K E ++   
Sbjct: 1089 CQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE-----IEAERA---TRAKTEKQRSDY 1140

Query: 861  IRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLR 920
             R+ ++  + L++     S Q+    KK + + L+ +  +     ++E      M A+LR
Sbjct: 1141 ARELEELSERLEEAGGVTSTQIE-LNKKREAEFLKLRRDLEEATLQHEA-----MVAALR 1194

Query: 921  QELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
            ++  D+++ L  Q++ LQ+    L++E + ++
Sbjct: 1195 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score =  127 bits (320), Expect = 4e-29
 Identities = 172/765 (22%), Positives = 347/765 (45%), Gaps = 94/765 (12%)

Query: 260  KTKMMEAKFHEEKLKLQQKHDA--DVQKILERKNNEIEELKTLYRSKQHETE--ETIRKL 315
            KT  ME K   +  +LQ   D    +++ + R +  + E++ +   K+ E +  ET R L
Sbjct: 443  KTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSL 502

Query: 316  -EKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQ 374
             E+ + T I +C  ++ + E    E+ +  +++ + L++  E+     + E++++++  Q
Sbjct: 503  LEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS--RKLQEIKEQEYQAQ 560

Query: 375  KQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKL 434
             +    +   LE+  V   +    Y ++ + +    +E + +  +   +   +  Q +  
Sbjct: 561  VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 620

Query: 435  IQEKAELERC---YQITCSELQEVKARRNTLHKEKDHLVNDY-------EQNMKLLQTKY 484
            + E A+LE+     Q+   ELQE   +      E   L+ +        E+ ++ LQ + 
Sbjct: 621  VGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE 680

Query: 485  DADINL---------LKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQE 535
            D+   +         L+++H  +   A  +   L+Q     +++++  + Q K+ L D+E
Sbjct: 681  DSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 740

Query: 536  NKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKK--IHKFEEALKEKEEQLTRVTEVQR 593
                M + H     E++AH      +KGK  +++K  I+  +  ++  E+++  ++E  +
Sbjct: 741  TLENMMQRH-----EEEAH------EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 789

Query: 594  LQAQQADAALEEFKRQVELNSE----KVYAE------------MKEQMEKV----EADLT 633
            L A  +       K Q E+ SE    K Y E            ++EQ+EK+     +D  
Sbjct: 790  LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN 849

Query: 634  RSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL--LQQHNAEKDSLVRDHE 691
            R   L E + +E   + E+ +   ++Q+ EL+L  ++ ++ L  LQ   A  +S +R  +
Sbjct: 850  RLLEL-ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 908

Query: 692  REIE----NLEKQLRAANMEHENQIQ---EFKKRDAQVIADMEAQVHKLRE---ELINVN 741
             E+E      E++++A    H ++IQ   +  +    VI D+E Q+++L E   EL N N
Sbjct: 909  TELEETTAEAEEEIQALT-AHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQN 967

Query: 742  SQRKQQLVELGLLREEEKQ-RATREH---EIVVNKLKAESEKMKIELKKTHAA---ETEM 794
                +QL E     +E  Q R+  +H   EI   +++  S+K  +E  KT      E  M
Sbjct: 968  FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 1027

Query: 795  TLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK---EENSQQQLAAERRLQDVRQ 851
             LE  N +L + E+++    +      ++ +  +  L+   +   Q +  A++R+ + RQ
Sbjct: 1028 DLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 1087

Query: 852  KFE---DEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYE 908
              E    E K  I    QA+K  + + E+ S+++   EKK  H  LE   +    + E E
Sbjct: 1088 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKK--HAMLEMNARSLQQKLETE 1145

Query: 909  TKLKGLM---PASLRQELE---DTISSLKSQVNFLQKRASILQEE 947
             +LK  +    A L+Q+++   + I  L   +     RA +L+ E
Sbjct: 1146 RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTE 1190



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 119/588 (20%), Positives = 269/588 (45%), Gaps = 88/588 (14%)

Query: 414 EARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDY 473
           E+ V  L   A+ S+++++ LI+ K EL+   Q  C ++++   R +    E + +++  
Sbjct: 432 ESVVSGLDSPAKTSSMEKKLLIKSK-ELQDS-QDKCHKMEQEMTRLHRRVSEVEAVLSQK 489

Query: 474 EQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQ---------------------- 511
           E  +K  +T+     +LL+Q+ A   ++ SS+   LEQ                      
Sbjct: 490 EVELKASETQR----SLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQ 545

Query: 512 --NVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYE--------------KKAHD 555
              + ++K+Q  +++++  + + +Q  +  +       +YE              +KA +
Sbjct: 546 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATE 605

Query: 556 LQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSE 615
            Q +L K K+  + ++ ++ +  K   EQ  ++ E+Q    +   A+ E  +    +   
Sbjct: 606 CQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA 665

Query: 616 KVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL 675
           K  AE   ++EK++     S+ +R+K     L + E++ +++ +   ++  +H +     
Sbjct: 666 KERAE--RELEKLQNREDSSEGIRKK-----LVEAEELEEKHRE--AQVSAQHLEVHLKQ 716

Query: 676 LQQHNAEK----DSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVH 731
            +QH  EK    D+ ++    + E LE  ++     HE +  E      +++++ +A ++
Sbjct: 717 KEQHYEEKIKVLDNQIKKDLADKETLENMMQ----RHEEEAHE----KGKILSEQKAMIN 768

Query: 732 KLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAE 791
            +  ++ ++    +Q++VEL     E  + A          +KA+ E +    ++    E
Sbjct: 769 AMDSKIRSL----EQRIVEL----SEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 820

Query: 792 TEM-TLEKANSKL-KQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDV 849
           T+   LE  N KL +Q+EK   Q  +  ++++ EL+T +  +  E+ +Q+L  +R+L ++
Sbjct: 821 TQAGKLEAQNRKLEEQLEKISHQDHSDKNRLL-ELETRLREVSLEHEEQKLELKRQLTEL 879

Query: 850 RQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI---TYIRQE 906
           +   ++ + QL      A++  +  LE   +Q+R A+ +L+    E++E+I   T  R E
Sbjct: 880 QLSLQERESQL-----TALQAARAALE---SQLRQAKTELEETTAEAEEEIQALTAHRDE 931

Query: 907 YETKLKGLM-PASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQG 953
            + K   L    ++  +LE+ ++ L      L  +   L ++L    G
Sbjct: 932 IQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG 979



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 149/691 (21%), Positives = 293/691 (42%), Gaps = 119/691 (17%)

Query: 234  KFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERK-NN 292
            K   R+ SS      L    E E   +   + A+  E  LK +++H  +  K+L+ +   
Sbjct: 675  KLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKK 734

Query: 293  EIEELKTLYRSKQHETEETIRK----LEKKVQTLIRDCQVIR-ETKEDQIAELKKICEQS 347
            ++ + +TL    Q   EE   K     E+K      D ++   E +  +++E  K+   S
Sbjct: 735  DLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS 794

Query: 348  TESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTN 407
            +     +  K     ++E+ Q+KF L+ Q  +     LE  N +L +   +   Q  S  
Sbjct: 795  SLFTQRNM-KAQEEMISELRQQKFYLETQAGK-----LEAQNRKLEEQLEKISHQDHSDK 848

Query: 408  HMIKELEARVQQLTGEAENSNLQRQK-----------------------------LIQEK 438
            + + ELE R+++++ E E   L+ ++                             L Q K
Sbjct: 849  NRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 908

Query: 439  AELERCYQITCSELQEVKARRNTLHKEKDHL------VNDYEQNMKLLQTKYDADINLLK 492
             ELE        E+Q + A R+ + ++ D L      + D E+ +  L T+ +A++N   
Sbjct: 909  TELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL-TEDNAELN--N 965

Query: 493  QEHALS-----ASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKH 547
            Q   LS     AS A+  I +L   V  L++++ E    R+ QL  Q+   +  K+    
Sbjct: 966  QNFYLSKQLDEASGANDEIVQLRSEVDHLRREITE----REMQLTSQKQTMEALKTTCT- 1020

Query: 548  IYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQL-TRVTEVQRL------QAQQAD 600
            + E++  DL++  D+  E  +++   +   L +++ Q   RV E+QR+         +AD
Sbjct: 1021 MLEEQVMDLEALNDELLE-KERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARAD 1079

Query: 601  AALEEFKRQVELNSEKVYAE-------MKEQMEKVEA------DLTRSKSLREKQSKEFL 647
              + E ++ VEL  ++  AE       +KEQ  K E+      DL +  ++ E  ++   
Sbjct: 1080 QRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ 1139

Query: 648  WQLE---DIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVR---------DHEREIE 695
             +LE   +++QR  ++  +L+ + + +K H+ +     +++L R         D E ++E
Sbjct: 1140 QKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLE 1199

Query: 696  NLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLR 755
            N++       ++ E  I +      ++I  ++A++ +  ++   + S+RK          
Sbjct: 1200 NIQVLYSHEKVKMEGTISQ----QTKLIDFLQAKMDQPAKKKKGLFSRRK---------- 1245

Query: 756  EEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLA 815
              E      +  +  N+L     K+ +E +K   AE E  L+K   +L+   +E   + A
Sbjct: 1246 --EDPALPTQVPLQYNEL-----KLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 1298

Query: 816  -----KSSQIIAELQTTISSLKEENSQQQLA 841
                  S+   A  Q  +S++      Q  A
Sbjct: 1299 TDHPHPSTPATARQQIAMSAIVRSPEHQPSA 1329


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  127 bits (320), Expect = 4e-29
 Identities = 175/791 (22%), Positives = 346/791 (43%), Gaps = 151/791 (19%)

Query: 252  IREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKI--------------------LERKN 291
            + +K LD +T+  EA+  E    ++QKH   V+++                    LE++N
Sbjct: 1185 VLKKALDEETRSHEAQVQE----MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240

Query: 292  NEIE-ELKTLYRSKQHETEETIRKLEKKVQTLIRDC---QVIRETKEDQIAELKKICEQS 347
             ++  EL+ L ++KQ E E   +KLE +VQ L   C   +  R    D++ +L+   E  
Sbjct: 1241 ADLAGELRVLGQAKQ-EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299

Query: 348  TESLNNDWEK--KLHNAVAEMEQEKFDLQKQHTEN----------IQELLEDTNVRLNKM 395
            T  LN    K  KL   VA +  +  D Q+   E           +++L E+ N   +++
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359

Query: 396  ESEYMAQTQSTNHM------IKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 449
            + E  A+     H+      + + + ++Q      E     +++  +E   L + Y+   
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419

Query: 450  SELQEVKARRNTLHKEKDHLVNDYEQNMKLL------QTKYD---ADINLLKQEHALSAS 500
            +   +++  +N L +E D LV D +   +L+      Q K+D   A+   +  ++A    
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479

Query: 501  KASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSEL 560
            +A +   E E     L + L+E+ L+ K++L   E   +M K+ ++            +L
Sbjct: 1480 RAEAEAREKETKALSLARALEEA-LEAKEEL---ERTNKMLKAEME------------DL 1523

Query: 561  DKGKEDTQKKIHKFEEALKEKEEQLTRV-TEVQRLQAQQADAALEEFKRQVELNSEKVYA 619
               K+D  K +H+ E++ +  E Q+  + T+++ L+ +    A E+ K ++E+N + +  
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--ATEDAKLRLEVNMQALKG 1581

Query: 620  EMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR-QRYEQQIVELKLEHEQEKTHLLQQ 678
            + +  ++  +      +   ++Q  E+  +LED R QR      + KLE + +   L   
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL--- 1638

Query: 679  HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEA 728
               + DS ++  E  I+ L K L+A   + + ++++ +    ++ A           +EA
Sbjct: 1639 ---QADSAIKGREEAIKQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694

Query: 729  QVHKLREELINVNSQRKQQLVELGLLREE-------------EKQR-----ATREHEIVV 770
             + +L+E+L      RKQ  +E   L EE             EK+R     A  E E+  
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754

Query: 771  NK--LKAESEKMKIELKKTHAAETEMTLEK--------ANSKLKQIEKEYTQKL------ 814
             +  ++A S++++   ++      E+  E+        A  +L++  KE   KL      
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814

Query: 815  --AKSSQIIAELQTTISSLKEENSQQ----QLAA------ERRLQDVRQKFEDEKKQLIR 862
              +K    IA L+  I+ L+E+  Q+    Q A       +++L+++  + EDE+K   +
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 863  DNDQA---------IKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQE---YETK 910
              +QA         +K   +E E  S ++    +KLQ +  E+ E    + +E    ++K
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934

Query: 911  LKGLMPASLRQ 921
            L+G  P    Q
Sbjct: 1935 LRGPPPQETSQ 1945



 Score =  125 bits (314), Expect = 2e-28
 Identities = 154/670 (22%), Positives = 294/670 (43%), Gaps = 99/670 (14%)

Query: 314  KLEKKVQTLIRDCQVIRETKEDQIAE--LKKICEQSTESLNNDWEKKLHNAVAEMEQEKF 371
            +L  KV+ L+   QV R+ +E Q  E  L+K  E+         ++K  N + E+EQ+  
Sbjct: 843  RLFTKVKPLL---QVTRQEEEMQAKEDELQKTKER---------QQKAENELKELEQKHS 890

Query: 372  DLQKQHTENIQELLEDTNV--RLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
             L ++     ++L  +T +     +M     A+ Q    ++ E+EAR+++     +    
Sbjct: 891  QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 950

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKY---DA 486
            +R+K+ Q+  +LE        +L+E +A R  L  EK       E  +K L+ +    D 
Sbjct: 951  ERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDD 999

Query: 487  DINLLKQEHALSASKASSMI------EELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
              N L +E  L   + S +       EE  +N+ +LK +  ES +   +    +E K + 
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1058

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD 600
            E   LK   E  A D   ++     D Q +I + +  L +KEE+L           Q A 
Sbjct: 1059 ELEKLKRKLEGDASDFHEQI----ADLQAQIAELKMQLAKKEEEL-----------QAAL 1103

Query: 601  AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660
            A L++   Q   N+ K   E++  +  ++ DL   ++ R K  K    Q  D+ +  E +
Sbjct: 1104 ARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGE--ELE 1156

Query: 661  IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA 720
             ++ +LE   + T   Q+  A++       E+E+  L+K L      HE Q+QE +++ A
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKR-------EQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            Q + ++  Q+ + +    N++  ++    E   L  E +     + E+   K K E++  
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269

Query: 781  KIELKKTHAAETEMTLEKANSKLKQIEKEYTQ-------------KLAKS-SQIIAELQT 826
            +++ K    ++ E    + N K+ +++ E                KLAK  + + ++LQ 
Sbjct: 1270 ELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 827  TISSLKEENSQQQLAAE--RRLQDVRQKFED------EKKQLIRDNDQAIKVLQDELENR 878
            T   L+EE  Q+   +   R+L++ R   +D      E KQ +  +   + +   + + +
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 879  SNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGL-----MPASLRQELEDTISSLKSQ 933
                    + L+  +   Q++I  + Q+YE K             L+QEL+D +  L +Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 934  ---VNFLQKR 940
               V+ L+K+
Sbjct: 1447 RQLVSNLEKK 1456



 Score =  123 bits (308), Expect = 9e-28
 Identities = 163/731 (22%), Positives = 324/731 (44%), Gaps = 134/731 (18%)

Query: 274  KLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETK 333
            ++Q K D ++QK  ER+     ELK L +     TEE    L++++Q    + ++  E +
Sbjct: 860  EMQAKED-ELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQLQA---ETELYAEAE 914

Query: 334  EDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQK--QHTENIQELLEDTNVR 391
            E ++    K  +Q  E + ++ E +L       +Q + + +K  Q   +++E LE+    
Sbjct: 915  EMRVRLAAK--KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 392  LNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSE 451
              K++ E +    +    IK+LE  +  L  + +N+ L +++ + E    ER   +T + 
Sbjct: 973  RQKLQLEKV----TAEAKIKKLEDEI--LVMDDQNNKLSKERKLLE----ERISDLTTNL 1022

Query: 452  LQEVKARRN--TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL 509
             +E +  +N   L  + + ++++ E  +K  + K   ++  LK++    AS     I +L
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADL 1081

Query: 510  EQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAH--DLQSELDKGKEDT 567
            +  + +LK QL + E + +  L   +++   + + LK I E + H  DLQ +LD      
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----- 1136

Query: 568  QKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK 627
                   E A + K E+          Q +     LE  K ++E   +   A  +E   K
Sbjct: 1137 -------ERAARNKAEK----------QKRDLGEELEALKTELEDTLDST-ATQQELRAK 1178

Query: 628  VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK---------THLLQQ 678
             E ++T  K   +++++    Q++++RQ++ Q + EL  + EQ K            L++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 679  HNAEKDSLVR---DHEREIENLEKQLRAANMEHENQIQEFKKR---DAQVIADMEAQVHK 732
             NA+    +R     ++E+E+ +K+L A       Q+QE + +     +  A++  +VHK
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEA-------QVQELQSKCSDGERARAELNDKVHK 1291

Query: 733  LREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAET 792
            L+ E+ +V           G+L E E +           KL  +   +  +L+ T     
Sbjct: 1292 LQNEVESVT----------GMLNEAEGKAI---------KLAKDVASLSSQLQDTQELLQ 1332

Query: 793  EMTLEKAN--SKLKQIEKEYTQ------------------------KLAKSSQIIAELQT 826
            E T +K N  +KL+Q+E+E                           +L+ S + + +  +
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392

Query: 827  TISSLKE---------ENSQQQ----LAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQ- 872
            T+ +L+E         EN  QQ     AA  +L+  + + + E   L+ D D   +++  
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 873  -DELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPA-----SLRQELEDT 926
             ++ + + +Q+   EK +  K  + +++     +E ETK   L  A       ++ELE T
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 927  ISSLKSQVNFL 937
               LK+++  L
Sbjct: 1513 NKMLKAEMEDL 1523



 Score =  123 bits (308), Expect = 9e-28
 Identities = 187/820 (22%), Positives = 344/820 (41%), Gaps = 153/820 (18%)

Query: 250  SRIREKELDMKTKMME---------------AKFHEE---------KLKLQ-QKHDADVQ 284
            S I E E+ +K +                  + FHE+         +LK+Q  K + ++Q
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100

Query: 285  KILER-------KNNEIEELKTL-------------YRSKQHETEETIRKLEKKVQTLIR 324
              L R       KNN +++++ L              R+ +++ E+  R L ++++ L  
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1160

Query: 325  DC----------QVIRETKEDQIAELKKICEQST---ESLNNDWEKKLHNAVAEMEQ--E 369
            +           Q +R  +E ++  LKK  ++ T   E+   +  +K   AV E+ +  E
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220

Query: 370  KFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
            +F   K + +  ++ LE  N  L           Q   H  K+LEA+VQ+L  +  +   
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADIN 489
             R +L  +  +L+   +     L E + +   L K+   L +  +   +LLQ +    +N
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340

Query: 490  L---LKQEHALSASKASSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQ 534
            +   L+Q      S    + EE      LE+++  L  QL +S+ + +      + L + 
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400

Query: 535  ENKFQMEKSHLKHIYEKKA-----------------HDLQSELDKGKE---DTQKKIHKF 574
            + +FQ E  +L   YE+KA                  DL  +LD  ++   + +KK  KF
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460

Query: 575  EEALKEKE-------------EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
            ++ L E++             E   R  E + L   +A     E K ++E  ++ + AEM
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520

Query: 622  ------KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL 675
                  K+ + K   +L +SK   E Q +E   QLE++     Q   + KL  E     L
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQAL 1579

Query: 676  LQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------D 725
              Q   E+D   RD +   E   +QL+    E+E ++++ +K+ A   A          D
Sbjct: 1580 KGQF--ERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 726  MEAQVH---KLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKI 782
            +E Q     K REE I     RK Q       RE E  RA+R+ EI     + E +   +
Sbjct: 1636 LELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRD-EIFATAKENEKKAKSL 1692

Query: 783  ELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQ--QL 840
            E       E     E+A  +    ++E  ++LA             SSL   N+ Q  + 
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELA-------------SSLSGRNALQDEKR 1739

Query: 841  AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI 900
              E R+  + ++ E+E+  +   +D+  K  Q + E  SN++   E+    K   +++Q+
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNEL-ATERSTAQKNESARQQL 1797

Query: 901  TYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKR 940
                +E  +KL   M  +++ + + TI++L++++  L+++
Sbjct: 1798 ERQNKELRSKLHE-MEGAVKSKFKSTIAALEAKIAQLEEQ 1836



 Score =  122 bits (305), Expect = 2e-27
 Identities = 183/779 (23%), Positives = 324/779 (41%), Gaps = 120/779 (15%)

Query: 271  EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIR 330
            +K++  + H +D+Q+ L+ +     + +   R    E E    +LE  + +     Q +R
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELR 1176

Query: 331  ETKEDQIAELKKICEQSTESLN---NDWEKKLHNAVAEMEQ--EKFDLQKQHTENIQELL 385
              +E ++  LKK  ++ T S      +  +K   AV E+ +  E+F   K + +  ++ L
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236

Query: 386  EDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
            E  N  L           Q   H  K+LEA+VQ+L  +  +    R +L  +  +L+   
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 446  QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINL---LKQEHALSASKA 502
            +     L E + +   L K+   L +  +   +LLQ +    +N+   L+Q      S  
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 503  SSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQENKFQMEKSHLKHIYE 550
              + EE      LE+++  L  QL +S+ + +      + L + + +FQ E  +L   YE
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 551  KKA-----------------HDLQSELDKGKE---DTQKKIHKFEEALKEKE-------- 582
            +KA                  DL  +LD  ++   + +KK  KF++ L E++        
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 583  -----EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM------KEQMEKVEAD 631
                 E   R  E + L   +A     E K ++E  ++ + AEM      K+ + K   +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536

Query: 632  LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE 691
            L +SK   E Q +E   QLE++     Q   + KL  E     L  Q   E+D   RD +
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQF--ERDLQARDEQ 1593

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEAQVH---KLREELI 738
             E +   +QL+    E+E ++++ +K+ A   A          D+E Q     K REE I
Sbjct: 1594 NEEKR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 739  NVNSQRKQQLVELGLLREEEKQRATREHEIVV---NKLKAESEKMKIELKKTHAAETEMT 795
                 RK Q       RE E  RA+R+        N+ KA+S +  +   +   A  E  
Sbjct: 1652 K--QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 796  LEKANSKLKQIEKEYTQKLAKSSQIIAE---LQTTISSLKEENSQQQLAAERRLQDVR-- 850
             ++A+ + +++ +E    L+  + +  E   L+  I+ L+EE  ++Q   E     VR  
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769

Query: 851  ------------------QKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK---- 888
                              QK E  ++QL R N    K L+ +L      V+   K     
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 889  LQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
            L+ K  + +EQ+     E E + K     SL+Q+ +  +  +  QV   +K A   +E+
Sbjct: 1826 LEAKIAQLEEQV-----EQEAREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQ 1878



 Score =  121 bits (303), Expect = 4e-27
 Identities = 170/787 (21%), Positives = 359/787 (45%), Gaps = 109/787 (13%)

Query: 251  RIREKELDMKTKMMEAKFHEEKLKLQQ-KHDADVQK------ILERKNNEIEELKTLYRS 303
            ++ ++ LD++ ++ E +   +KL+L++   +A ++K      +++ +NN++ + + L   
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 304  K----------QHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNN 353
            +          + E  + + KL+ K +++I + +V  + +E    EL+K+ ++  E   +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL-KRKLEGDAS 1072

Query: 354  DWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKEL 413
            D+ +++ +  A++ + K  L K+         E+    L +++ E +AQ  +    I+EL
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKE--------EELQAALARLDDE-IAQKNNALKKIREL 1123

Query: 414  EARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV---KARRNTLHKEKDHLV 470
            E  +  L  + ++    R K  ++K +L    +   +EL++     A +  L  +++  V
Sbjct: 1124 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1183

Query: 471  NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQ---NVCQLKQQLQESELQR 527
               ++ +      ++A +  ++Q+HA +  + +  +E+ ++   N+ + KQ L++     
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 528  KQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKE---DTQKKIHKFEEA------- 577
              +LR    + + E  H K   E +  +LQS+   G+    +   K+HK +         
Sbjct: 1244 AGELRVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302

Query: 578  LKEKEEQLTRVT-EVQRLQAQQADAA--LEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
            L E E +  ++  +V  L +Q  D    L+E  RQ +LN      +++E+   ++  L  
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERNSLQDQLDE 1361

Query: 635  ---SKSLREKQSKEFLWQLEDIRQRYE------QQIVELKLEHEQEKTHLLQQHNAEKDS 685
               +K   E+       QL D +++ +      + + E K   ++E  +L QQ+  EK +
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAA 1420

Query: 686  LVRDHEREIENLEKQLRAANMEHENQ------IQEFKKRDAQVIADMEAQVHKLREELIN 739
                 E+    L+++L    ++ +NQ      +++ +++  Q++A+ +    K  +E   
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480

Query: 740  VNSQ-RKQQLVELGLLRE-EEKQRATREHEIVVNKLKAESE----------KMKIELKKT 787
              ++ R+++   L L R  EE   A  E E     LKAE E          K   EL+K+
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540

Query: 788  -HAAETEMT-----LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLA 841
              A ET+M      LE+   +L+  E    +       +  + +  + +  E+N +++  
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 842  AERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK----------KLQ- 890
             +R+L +   + EDE+KQ       A K L+ +L++   Q   A K          KLQ 
Sbjct: 1601 LQRQLHEYETELEDERKQRAL-AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659

Query: 891  -----HKELE----SQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRA 941
                  +ELE    S+++I    +E E K K L  A L Q  ED  ++ ++     +K+A
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERA-----RKQA 1713

Query: 942  SILQEEL 948
             + +EEL
Sbjct: 1714 DLEKEEL 1720



 Score =  120 bits (301), Expect = 6e-27
 Identities = 152/742 (20%), Positives = 345/742 (46%), Gaps = 83/742 (11%)

Query: 257  LDMKTKMMEAKFHEEKLKLQQKHDADVQKILERK---------NNEIEELKTLYRSKQHE 307
            L  K + +E   HE + +L+++ D   Q   ERK           ++EE +   +  Q E
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 308  ---TEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK------KICEQSTESLNNDWEKK 358
                E  I+KLE ++  L+ D Q  + +KE ++ E +       + E+  ++ N    K 
Sbjct: 980  KVTAEAKIKKLEDEI--LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037

Query: 359  LHNAV---AEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEA 415
             H ++    E+  +K +  +Q  E ++  LE      ++  ++  AQ       + + E 
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097

Query: 416  RVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ 475
             +Q      ++   Q+   +++  ELE        +L   +A RN   K+K     D  +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK----RDLGE 1153

Query: 476  NMKLLQTKYDADINLLKQEHALSASK-------ASSMIEELEQNVCQLKQQLQESELQRK 528
             ++ L+T+ +  ++    +  L A +         ++ EE   +  Q+ Q++++   Q  
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV-QEMRQKHAQAV 1212

Query: 529  QQLRDQENKFQMEKSHL---KHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQL 585
            ++L +Q  +F+  K++L   K   EK+  DL  EL    +  Q+  HK ++   + +E  
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 586  TRVTEVQRLQAQQADAALEEFKRQVE-----LN-SEKVYAEMKEQMEKVEADLTRSKSLR 639
            ++ ++ +R +A+  D  + + + +VE     LN +E    ++ + +  + + L  ++ L 
Sbjct: 1273 SKCSDGERARAELND-KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331

Query: 640  EKQSKEFLWQLEDIRQ-RYEQQIVELKLEHEQEKTHLLQQH-------NAEKDSLVRDHE 691
            ++++++ L     +RQ   E+  ++ +L+ E E    L++H        ++    ++D  
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREEL--INVNSQRKQQLV 749
              +E LE+  +    E EN  Q+++++ A     +E   ++L++EL  + V+   ++QLV
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450

Query: 750  ELGLLREEEKQRATREHEIVVNKLKAESEKMKIEL--KKTHAAETEMTLEKANSKLKQIE 807
                 ++ +  +   E + + +K   E ++ + E   K+T A      LE+A    +++E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 808  KEYTQKLAKSSQIIAELQTTISSLKE------ENSQQQLAAERRLQDVRQKFEDEKKQLI 861
            +  T K+ K     AE++  +SS  +      E  + + A E ++++++ + E+ + +L 
Sbjct: 1511 R--TNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563

Query: 862  RDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQ---EYETKLKG----- 913
               D  ++ L+  ++    Q    E+ LQ ++ +++E+   +++   EYET+L+      
Sbjct: 1564 ATEDAKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619

Query: 914  LMPASLRQELEDTISSLKSQVN 935
             + A+ +++LE  +  L+ Q +
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQAD 1641



 Score =  108 bits (271), Expect = 2e-23
 Identities = 141/723 (19%), Positives = 334/723 (46%), Gaps = 96/723 (13%)

Query: 163  GKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLR 222
            G+LRV   +      +  + +  ++ E+ SK S      +++  +++     +E+   + 
Sbjct: 1245 GELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303

Query: 223  QKPIPVSLMTPKFSLRKSSSFHD-DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDA 281
             +    ++   K     SS   D    L     ++L++ TK+ + +     L+ Q   + 
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363

Query: 282  DVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK 341
            + ++ LER  + +    +  + K  +   T+  LE+  +   ++ + + +  E++ A   
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423

Query: 342  KICEQSTESLNNDWEKKLHNAVAEMEQEK---FDLQKQHTENIQELLEDTNVRLNKMESE 398
            K+     E   N  +++L + V +++ ++    +L+K+  +  Q L E+ N+      S+
Sbjct: 1424 KL-----EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-----SSK 1473

Query: 399  YMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKAR 458
            Y  +        +E E +   L    E +       ++ K ELER  ++  +E++++ + 
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1526

Query: 459  RNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ-EHALSASKASSMIEELEQNVCQLK 517
            ++ + K     V++ E++ + L+T+ +     L++ E  L A++ + +   LE N+  LK
Sbjct: 1527 KDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL--RLEVNMQALK 1580

Query: 518  QQLQ-------ESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKK 570
             Q +       E   ++++QL+ Q ++++ E        E+K   L +   K  E   K 
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKD 1635

Query: 571  IH-KFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVE---LNSEKVYAEMKEQME 626
            +  + + A+K +EE    + ++++LQAQ  D     F+R++E    + ++++A  KE  +
Sbjct: 1636 LELQADSAIKGREEA---IKQLRKLQAQMKD-----FQRELEDARASRDEIFATAKENEK 1687

Query: 627  K---VEADLT----------RSKSLREKQSKEFLWQL----------EDIRQRYEQQIVE 663
            K   +EADL           R++   + + +E   +L          +D ++R E +I +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 664  LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQL---RAANMEHENQIQEFKKRDA 720
            L+ E E+E+ ++     A  D  VR   ++ E L  +L   R+   ++E+  Q+ ++++ 
Sbjct: 1748 LEEELEEEQGNM----EAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            ++ + +      ++ +  +  +  + ++ +L    EE+ ++  RE +     LK + +K+
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAATKSLKQKDKKL 1858

Query: 781  K-----IELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA---ELQTTISSLK 832
            K     +E ++  A + +   EK N+++KQ++++  +   +S +I A   +LQ  +    
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918

Query: 833  EEN 835
            E N
Sbjct: 1919 ESN 1921



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 39/178 (21%), Positives = 89/178 (50%), Gaps = 14/178 (7%)

Query: 773  LKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK 832
            L+   ++ +++ K+    +T+   +KA ++LK++E++++Q   + + +  +LQ       
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ------- 904

Query: 833  EENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHK 892
               ++ +L AE     VR      KKQ + +    ++   +E E+R  Q++   KK+  +
Sbjct: 905  ---AETELYAEAEEMRVRLA---AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 893  ELESQEQITYIRQ-EYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELT 949
             L+ +EQ+        + +L+ +   +  ++LED I  +  Q N L K   +L+E ++
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  127 bits (320), Expect = 4e-29
 Identities = 175/791 (22%), Positives = 346/791 (43%), Gaps = 151/791 (19%)

Query: 252  IREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKI--------------------LERKN 291
            + +K LD +T+  EA+  E    ++QKH   V+++                    LE++N
Sbjct: 1178 VLKKALDEETRSHEAQVQE----MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233

Query: 292  NEIE-ELKTLYRSKQHETEETIRKLEKKVQTLIRDC---QVIRETKEDQIAELKKICEQS 347
             ++  EL+ L ++KQ E E   +KLE +VQ L   C   +  R    D++ +L+   E  
Sbjct: 1234 ADLAGELRVLGQAKQ-EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292

Query: 348  TESLNNDWEK--KLHNAVAEMEQEKFDLQKQHTEN----------IQELLEDTNVRLNKM 395
            T  LN    K  KL   VA +  +  D Q+   E           +++L E+ N   +++
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1352

Query: 396  ESEYMAQTQSTNHM------IKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 449
            + E  A+     H+      + + + ++Q      E     +++  +E   L + Y+   
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412

Query: 450  SELQEVKARRNTLHKEKDHLVNDYEQNMKLL------QTKYD---ADINLLKQEHALSAS 500
            +   +++  +N L +E D LV D +   +L+      Q K+D   A+   +  ++A    
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472

Query: 501  KASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSEL 560
            +A +   E E     L + L+E+ L+ K++L   E   +M K+ ++            +L
Sbjct: 1473 RAEAEAREKETKALSLARALEEA-LEAKEEL---ERTNKMLKAEME------------DL 1516

Query: 561  DKGKEDTQKKIHKFEEALKEKEEQLTRV-TEVQRLQAQQADAALEEFKRQVELNSEKVYA 619
               K+D  K +H+ E++ +  E Q+  + T+++ L+ +    A E+ K ++E+N + +  
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--ATEDAKLRLEVNMQALKG 1574

Query: 620  EMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR-QRYEQQIVELKLEHEQEKTHLLQQ 678
            + +  ++  +      +   ++Q  E+  +LED R QR      + KLE + +   L   
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL--- 1631

Query: 679  HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEA 728
               + DS ++  E  I+ L K L+A   + + ++++ +    ++ A           +EA
Sbjct: 1632 ---QADSAIKGREEAIKQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687

Query: 729  QVHKLREELINVNSQRKQQLVELGLLREE-------------EKQR-----ATREHEIVV 770
             + +L+E+L      RKQ  +E   L EE             EK+R     A  E E+  
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747

Query: 771  NK--LKAESEKMKIELKKTHAAETEMTLEK--------ANSKLKQIEKEYTQKL------ 814
             +  ++A S++++   ++      E+  E+        A  +L++  KE   KL      
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807

Query: 815  --AKSSQIIAELQTTISSLKEENSQQ----QLAA------ERRLQDVRQKFEDEKKQLIR 862
              +K    IA L+  I+ L+E+  Q+    Q A       +++L+++  + EDE+K   +
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 863  DNDQA---------IKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQE---YETK 910
              +QA         +K   +E E  S ++    +KLQ +  E+ E    + +E    ++K
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927

Query: 911  LKGLMPASLRQ 921
            L+G  P    Q
Sbjct: 1928 LRGPPPQETSQ 1938



 Score =  125 bits (314), Expect = 2e-28
 Identities = 154/670 (22%), Positives = 294/670 (43%), Gaps = 99/670 (14%)

Query: 314  KLEKKVQTLIRDCQVIRETKEDQIAE--LKKICEQSTESLNNDWEKKLHNAVAEMEQEKF 371
            +L  KV+ L+   QV R+ +E Q  E  L+K  E+         ++K  N + E+EQ+  
Sbjct: 836  RLFTKVKPLL---QVTRQEEEMQAKEDELQKTKER---------QQKAENELKELEQKHS 883

Query: 372  DLQKQHTENIQELLEDTNV--RLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
             L ++     ++L  +T +     +M     A+ Q    ++ E+EAR+++     +    
Sbjct: 884  QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 943

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKY---DA 486
            +R+K+ Q+  +LE        +L+E +A R  L  EK       E  +K L+ +    D 
Sbjct: 944  ERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDD 992

Query: 487  DINLLKQEHALSASKASSMI------EELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
              N L +E  L   + S +       EE  +N+ +LK +  ES +   +    +E K + 
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1051

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD 600
            E   LK   E  A D   ++     D Q +I + +  L +KEE+L           Q A 
Sbjct: 1052 ELEKLKRKLEGDASDFHEQI----ADLQAQIAELKMQLAKKEEEL-----------QAAL 1096

Query: 601  AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660
            A L++   Q   N+ K   E++  +  ++ DL   ++ R K  K    Q  D+ +  E +
Sbjct: 1097 ARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGE--ELE 1149

Query: 661  IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA 720
             ++ +LE   + T   Q+  A++       E+E+  L+K L      HE Q+QE +++ A
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKR-------EQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            Q + ++  Q+ + +    N++  ++    E   L  E +     + E+   K K E++  
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262

Query: 781  KIELKKTHAAETEMTLEKANSKLKQIEKEYTQ-------------KLAKS-SQIIAELQT 826
            +++ K    ++ E    + N K+ +++ E                KLAK  + + ++LQ 
Sbjct: 1263 ELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 827  TISSLKEENSQQQLAAE--RRLQDVRQKFED------EKKQLIRDNDQAIKVLQDELENR 878
            T   L+EE  Q+   +   R+L++ R   +D      E KQ +  +   + +   + + +
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 879  SNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGL-----MPASLRQELEDTISSLKSQ 933
                    + L+  +   Q++I  + Q+YE K             L+QEL+D +  L +Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 934  ---VNFLQKR 940
               V+ L+K+
Sbjct: 1440 RQLVSNLEKK 1449



 Score =  123 bits (308), Expect = 9e-28
 Identities = 163/731 (22%), Positives = 324/731 (44%), Gaps = 134/731 (18%)

Query: 274  KLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETK 333
            ++Q K D ++QK  ER+     ELK L +     TEE    L++++Q    + ++  E +
Sbjct: 853  EMQAKED-ELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQLQA---ETELYAEAE 907

Query: 334  EDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQK--QHTENIQELLEDTNVR 391
            E ++    K  +Q  E + ++ E +L       +Q + + +K  Q   +++E LE+    
Sbjct: 908  EMRVRLAAK--KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 392  LNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSE 451
              K++ E +    +    IK+LE  +  L  + +N+ L +++ + E    ER   +T + 
Sbjct: 966  RQKLQLEKV----TAEAKIKKLEDEI--LVMDDQNNKLSKERKLLE----ERISDLTTNL 1015

Query: 452  LQEVKARRN--TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL 509
             +E +  +N   L  + + ++++ E  +K  + K   ++  LK++    AS     I +L
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADL 1074

Query: 510  EQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAH--DLQSELDKGKEDT 567
            +  + +LK QL + E + +  L   +++   + + LK I E + H  DLQ +LD      
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----- 1129

Query: 568  QKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK 627
                   E A + K E+          Q +     LE  K ++E   +   A  +E   K
Sbjct: 1130 -------ERAARNKAEK----------QKRDLGEELEALKTELEDTLDST-ATQQELRAK 1171

Query: 628  VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK---------THLLQQ 678
             E ++T  K   +++++    Q++++RQ++ Q + EL  + EQ K            L++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 679  HNAEKDSLVR---DHEREIENLEKQLRAANMEHENQIQEFKKR---DAQVIADMEAQVHK 732
             NA+    +R     ++E+E+ +K+L A       Q+QE + +     +  A++  +VHK
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEA-------QVQELQSKCSDGERARAELNDKVHK 1284

Query: 733  LREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAET 792
            L+ E+ +V           G+L E E +           KL  +   +  +L+ T     
Sbjct: 1285 LQNEVESVT----------GMLNEAEGKAI---------KLAKDVASLSSQLQDTQELLQ 1325

Query: 793  EMTLEKAN--SKLKQIEKEYTQ------------------------KLAKSSQIIAELQT 826
            E T +K N  +KL+Q+E+E                           +L+ S + + +  +
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385

Query: 827  TISSLKE---------ENSQQQ----LAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQ- 872
            T+ +L+E         EN  QQ     AA  +L+  + + + E   L+ D D   +++  
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445

Query: 873  -DELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPA-----SLRQELEDT 926
             ++ + + +Q+   EK +  K  + +++     +E ETK   L  A       ++ELE T
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 927  ISSLKSQVNFL 937
               LK+++  L
Sbjct: 1506 NKMLKAEMEDL 1516



 Score =  123 bits (308), Expect = 9e-28
 Identities = 187/820 (22%), Positives = 344/820 (41%), Gaps = 153/820 (18%)

Query: 250  SRIREKELDMKTKMME---------------AKFHEE---------KLKLQ-QKHDADVQ 284
            S I E E+ +K +                  + FHE+         +LK+Q  K + ++Q
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093

Query: 285  KILER-------KNNEIEELKTL-------------YRSKQHETEETIRKLEKKVQTLIR 324
              L R       KNN +++++ L              R+ +++ E+  R L ++++ L  
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1153

Query: 325  DC----------QVIRETKEDQIAELKKICEQST---ESLNNDWEKKLHNAVAEMEQ--E 369
            +           Q +R  +E ++  LKK  ++ T   E+   +  +K   AV E+ +  E
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213

Query: 370  KFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
            +F   K + +  ++ LE  N  L           Q   H  K+LEA+VQ+L  +  +   
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADIN 489
             R +L  +  +L+   +     L E + +   L K+   L +  +   +LLQ +    +N
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333

Query: 490  L---LKQEHALSASKASSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQ 534
            +   L+Q      S    + EE      LE+++  L  QL +S+ + +      + L + 
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393

Query: 535  ENKFQMEKSHLKHIYEKKA-----------------HDLQSELDKGKE---DTQKKIHKF 574
            + +FQ E  +L   YE+KA                  DL  +LD  ++   + +KK  KF
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453

Query: 575  EEALKEKE-------------EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
            ++ L E++             E   R  E + L   +A     E K ++E  ++ + AEM
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513

Query: 622  ------KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL 675
                  K+ + K   +L +SK   E Q +E   QLE++     Q   + KL  E     L
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQAL 1572

Query: 676  LQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------D 725
              Q   E+D   RD +   E   +QL+    E+E ++++ +K+ A   A          D
Sbjct: 1573 KGQF--ERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 726  MEAQVH---KLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKI 782
            +E Q     K REE I     RK Q       RE E  RA+R+ EI     + E +   +
Sbjct: 1629 LELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRD-EIFATAKENEKKAKSL 1685

Query: 783  ELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQ--QL 840
            E       E     E+A  +    ++E  ++LA             SSL   N+ Q  + 
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELA-------------SSLSGRNALQDEKR 1732

Query: 841  AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI 900
              E R+  + ++ E+E+  +   +D+  K  Q + E  SN++   E+    K   +++Q+
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNEL-ATERSTAQKNESARQQL 1790

Query: 901  TYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKR 940
                +E  +KL   M  +++ + + TI++L++++  L+++
Sbjct: 1791 ERQNKELRSKLHE-MEGAVKSKFKSTIAALEAKIAQLEEQ 1829



 Score =  122 bits (305), Expect = 2e-27
 Identities = 183/779 (23%), Positives = 324/779 (41%), Gaps = 120/779 (15%)

Query: 271  EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIR 330
            +K++  + H +D+Q+ L+ +     + +   R    E E    +LE  + +     Q +R
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELR 1169

Query: 331  ETKEDQIAELKKICEQSTESLN---NDWEKKLHNAVAEMEQ--EKFDLQKQHTENIQELL 385
              +E ++  LKK  ++ T S      +  +K   AV E+ +  E+F   K + +  ++ L
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229

Query: 386  EDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
            E  N  L           Q   H  K+LEA+VQ+L  +  +    R +L  +  +L+   
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 446  QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINL---LKQEHALSASKA 502
            +     L E + +   L K+   L +  +   +LLQ +    +N+   L+Q      S  
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 503  SSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQENKFQMEKSHLKHIYE 550
              + EE      LE+++  L  QL +S+ + +      + L + + +FQ E  +L   YE
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 551  KKA-----------------HDLQSELDKGKE---DTQKKIHKFEEALKEKE-------- 582
            +KA                  DL  +LD  ++   + +KK  KF++ L E++        
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 583  -----EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM------KEQMEKVEAD 631
                 E   R  E + L   +A     E K ++E  ++ + AEM      K+ + K   +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529

Query: 632  LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE 691
            L +SK   E Q +E   QLE++     Q   + KL  E     L  Q   E+D   RD +
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQF--ERDLQARDEQ 1586

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEAQVH---KLREELI 738
             E +   +QL+    E+E ++++ +K+ A   A          D+E Q     K REE I
Sbjct: 1587 NEEKR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 739  NVNSQRKQQLVELGLLREEEKQRATREHEIVV---NKLKAESEKMKIELKKTHAAETEMT 795
                 RK Q       RE E  RA+R+        N+ KA+S +  +   +   A  E  
Sbjct: 1645 K--QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 796  LEKANSKLKQIEKEYTQKLAKSSQIIAE---LQTTISSLKEENSQQQLAAERRLQDVR-- 850
             ++A+ + +++ +E    L+  + +  E   L+  I+ L+EE  ++Q   E     VR  
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762

Query: 851  ------------------QKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK---- 888
                              QK E  ++QL R N    K L+ +L      V+   K     
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 889  LQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
            L+ K  + +EQ+     E E + K     SL+Q+ +  +  +  QV   +K A   +E+
Sbjct: 1819 LEAKIAQLEEQV-----EQEAREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQ 1871



 Score =  121 bits (303), Expect = 4e-27
 Identities = 170/787 (21%), Positives = 359/787 (45%), Gaps = 109/787 (13%)

Query: 251  RIREKELDMKTKMMEAKFHEEKLKLQQ-KHDADVQK------ILERKNNEIEELKTLYRS 303
            ++ ++ LD++ ++ E +   +KL+L++   +A ++K      +++ +NN++ + + L   
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006

Query: 304  K----------QHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNN 353
            +          + E  + + KL+ K +++I + +V  + +E    EL+K+ ++  E   +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL-KRKLEGDAS 1065

Query: 354  DWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKEL 413
            D+ +++ +  A++ + K  L K+         E+    L +++ E +AQ  +    I+EL
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKE--------EELQAALARLDDE-IAQKNNALKKIREL 1116

Query: 414  EARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV---KARRNTLHKEKDHLV 470
            E  +  L  + ++    R K  ++K +L    +   +EL++     A +  L  +++  V
Sbjct: 1117 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1176

Query: 471  NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQ---NVCQLKQQLQESELQR 527
               ++ +      ++A +  ++Q+HA +  + +  +E+ ++   N+ + KQ L++     
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 528  KQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKE---DTQKKIHKFEEA------- 577
              +LR    + + E  H K   E +  +LQS+   G+    +   K+HK +         
Sbjct: 1237 AGELRVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295

Query: 578  LKEKEEQLTRVT-EVQRLQAQQADAA--LEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
            L E E +  ++  +V  L +Q  D    L+E  RQ +LN      +++E+   ++  L  
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERNSLQDQLDE 1354

Query: 635  ---SKSLREKQSKEFLWQLEDIRQRYE------QQIVELKLEHEQEKTHLLQQHNAEKDS 685
               +K   E+       QL D +++ +      + + E K   ++E  +L QQ+  EK +
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAA 1413

Query: 686  LVRDHEREIENLEKQLRAANMEHENQ------IQEFKKRDAQVIADMEAQVHKLREELIN 739
                 E+    L+++L    ++ +NQ      +++ +++  Q++A+ +    K  +E   
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473

Query: 740  VNSQ-RKQQLVELGLLRE-EEKQRATREHEIVVNKLKAESE----------KMKIELKKT 787
              ++ R+++   L L R  EE   A  E E     LKAE E          K   EL+K+
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533

Query: 788  -HAAETEMT-----LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLA 841
              A ET+M      LE+   +L+  E    +       +  + +  + +  E+N +++  
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 842  AERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK----------KLQ- 890
             +R+L +   + EDE+KQ       A K L+ +L++   Q   A K          KLQ 
Sbjct: 1594 LQRQLHEYETELEDERKQRAL-AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652

Query: 891  -----HKELE----SQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRA 941
                  +ELE    S+++I    +E E K K L  A L Q  ED  ++ ++     +K+A
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERA-----RKQA 1706

Query: 942  SILQEEL 948
             + +EEL
Sbjct: 1707 DLEKEEL 1713



 Score =  120 bits (301), Expect = 6e-27
 Identities = 152/742 (20%), Positives = 345/742 (46%), Gaps = 83/742 (11%)

Query: 257  LDMKTKMMEAKFHEEKLKLQQKHDADVQKILERK---------NNEIEELKTLYRSKQHE 307
            L  K + +E   HE + +L+++ D   Q   ERK           ++EE +   +  Q E
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 308  ---TEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK------KICEQSTESLNNDWEKK 358
                E  I+KLE ++  L+ D Q  + +KE ++ E +       + E+  ++ N    K 
Sbjct: 973  KVTAEAKIKKLEDEI--LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030

Query: 359  LHNAV---AEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEA 415
             H ++    E+  +K +  +Q  E ++  LE      ++  ++  AQ       + + E 
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090

Query: 416  RVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ 475
             +Q      ++   Q+   +++  ELE        +L   +A RN   K+K     D  +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK----RDLGE 1146

Query: 476  NMKLLQTKYDADINLLKQEHALSASK-------ASSMIEELEQNVCQLKQQLQESELQRK 528
             ++ L+T+ +  ++    +  L A +         ++ EE   +  Q+ Q++++   Q  
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV-QEMRQKHAQAV 1205

Query: 529  QQLRDQENKFQMEKSHL---KHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQL 585
            ++L +Q  +F+  K++L   K   EK+  DL  EL    +  Q+  HK ++   + +E  
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265

Query: 586  TRVTEVQRLQAQQADAALEEFKRQVE-----LN-SEKVYAEMKEQMEKVEADLTRSKSLR 639
            ++ ++ +R +A+  D  + + + +VE     LN +E    ++ + +  + + L  ++ L 
Sbjct: 1266 SKCSDGERARAELND-KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324

Query: 640  EKQSKEFLWQLEDIRQ-RYEQQIVELKLEHEQEKTHLLQQH-------NAEKDSLVRDHE 691
            ++++++ L     +RQ   E+  ++ +L+ E E    L++H        ++    ++D  
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREEL--INVNSQRKQQLV 749
              +E LE+  +    E EN  Q+++++ A     +E   ++L++EL  + V+   ++QLV
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443

Query: 750  ELGLLREEEKQRATREHEIVVNKLKAESEKMKIEL--KKTHAAETEMTLEKANSKLKQIE 807
                 ++ +  +   E + + +K   E ++ + E   K+T A      LE+A    +++E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503

Query: 808  KEYTQKLAKSSQIIAELQTTISSLKE------ENSQQQLAAERRLQDVRQKFEDEKKQLI 861
            +  T K+ K     AE++  +SS  +      E  + + A E ++++++ + E+ + +L 
Sbjct: 1504 R--TNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556

Query: 862  RDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQ---EYETKLKG----- 913
               D  ++ L+  ++    Q    E+ LQ ++ +++E+   +++   EYET+L+      
Sbjct: 1557 ATEDAKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612

Query: 914  LMPASLRQELEDTISSLKSQVN 935
             + A+ +++LE  +  L+ Q +
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQAD 1634



 Score =  108 bits (271), Expect = 2e-23
 Identities = 141/723 (19%), Positives = 334/723 (46%), Gaps = 96/723 (13%)

Query: 163  GKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLR 222
            G+LRV   +      +  + +  ++ E+ SK S      +++  +++     +E+   + 
Sbjct: 1238 GELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296

Query: 223  QKPIPVSLMTPKFSLRKSSSFHD-DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDA 281
             +    ++   K     SS   D    L     ++L++ TK+ + +     L+ Q   + 
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356

Query: 282  DVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK 341
            + ++ LER  + +    +  + K  +   T+  LE+  +   ++ + + +  E++ A   
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416

Query: 342  KICEQSTESLNNDWEKKLHNAVAEMEQEK---FDLQKQHTENIQELLEDTNVRLNKMESE 398
            K+     E   N  +++L + V +++ ++    +L+K+  +  Q L E+ N+      S+
Sbjct: 1417 KL-----EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-----SSK 1466

Query: 399  YMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKAR 458
            Y  +        +E E +   L    E +       ++ K ELER  ++  +E++++ + 
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1519

Query: 459  RNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ-EHALSASKASSMIEELEQNVCQLK 517
            ++ + K     V++ E++ + L+T+ +     L++ E  L A++ + +   LE N+  LK
Sbjct: 1520 KDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL--RLEVNMQALK 1573

Query: 518  QQLQ-------ESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKK 570
             Q +       E   ++++QL+ Q ++++ E        E+K   L +   K  E   K 
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKD 1628

Query: 571  IH-KFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVE---LNSEKVYAEMKEQME 626
            +  + + A+K +EE    + ++++LQAQ  D     F+R++E    + ++++A  KE  +
Sbjct: 1629 LELQADSAIKGREEA---IKQLRKLQAQMKD-----FQRELEDARASRDEIFATAKENEK 1680

Query: 627  K---VEADLT----------RSKSLREKQSKEFLWQL----------EDIRQRYEQQIVE 663
            K   +EADL           R++   + + +E   +L          +D ++R E +I +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 664  LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQL---RAANMEHENQIQEFKKRDA 720
            L+ E E+E+ ++     A  D  VR   ++ E L  +L   R+   ++E+  Q+ ++++ 
Sbjct: 1741 LEEELEEEQGNM----EAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            ++ + +      ++ +  +  +  + ++ +L    EE+ ++  RE +     LK + +K+
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAATKSLKQKDKKL 1851

Query: 781  K-----IELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA---ELQTTISSLK 832
            K     +E ++  A + +   EK N+++KQ++++  +   +S +I A   +LQ  +    
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911

Query: 833  EEN 835
            E N
Sbjct: 1912 ESN 1914



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 39/178 (21%), Positives = 89/178 (50%), Gaps = 14/178 (7%)

Query: 773  LKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK 832
            L+   ++ +++ K+    +T+   +KA ++LK++E++++Q   + + +  +LQ       
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ------- 897

Query: 833  EENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHK 892
               ++ +L AE     VR      KKQ + +    ++   +E E+R  Q++   KK+  +
Sbjct: 898  ---AETELYAEAEEMRVRLA---AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 893  ELESQEQITYIRQ-EYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELT 949
             L+ +EQ+        + +L+ +   +  ++LED I  +  Q N L K   +L+E ++
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  127 bits (320), Expect = 4e-29
 Identities = 191/872 (21%), Positives = 371/872 (42%), Gaps = 162/872 (18%)

Query: 220  YLRQKPIPVSLMTPKFSLRKSSSFHDD-HFLSRIREKELDMKTKMMEAKFHEEKLKLQQK 278
            Y + KP+  S  T K        F      L++   K  +++ KM+     +  L+LQ +
Sbjct: 837  YFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896

Query: 279  HDADVQKILERKNNEIEELKTLYRSKQHET-------EETIRKLEKKVQTLIRDCQVIRE 331
             +AD     E + +++ + K    +K  E        EE   +L  K + L  +C  +++
Sbjct: 897  AEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 956

Query: 332  TKED---QIAELKKICEQSTESLNNDWEKK--LHNAVAEMEQEKFDLQKQHTENIQELLE 386
              +D    +A+++K    +   + N  E+   L   +A++ +EK  LQ+ H    Q+ L+
Sbjct: 957  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH----QQTLD 1012

Query: 387  DTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELE---R 443
            D  +  +K+ +   A+T        +LE +V  L G  E        L + K +LE   +
Sbjct: 1013 DLQMEEDKVNTLTKAKT--------KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLK 1064

Query: 444  CYQITCSELQEVKARRNTLHKEKDH--------------LVNDYEQNMKLLQTKYDADIN 489
              Q +  + +  K + N   K+K+               L    ++ +K LQ + +    
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE 1124

Query: 490  LLKQEHALSASKASSMIEELEQNVCQLKQQLQES--------ELQRKQQLRDQENKFQME 541
             ++ E A S +KA     +L + + ++ ++L+E+        E+ +K++   Q+ +  +E
Sbjct: 1125 EIEAERA-SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183

Query: 542  KSHLKH-----IYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEV--QRL 594
            +S L+H        KK  D  +EL +  +  Q+   K E   KEK E    + ++     
Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLE---KEKSELKMEINDLASNME 1240

Query: 595  QAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDI- 653
               +A A  E+  R +E    ++  + +EQ   +  +L+  K+    +S EF  QL++  
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLIN-ELSAQKARLHTESGEFSRQLDEKD 1299

Query: 654  ---------RQRYEQQIVELKLEHEQEK------THLLQQHNAEKDSLVRDHEREIE--- 695
                     +Q + QQI ELK + E+E        H LQ    + D L   +E E E   
Sbjct: 1300 AMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359

Query: 696  NLEKQLRAANME--------------HENQIQEFKKRDAQVIADMEAQVHKLREELINV- 740
             L++ +  AN E                 +++E KK+ AQ + D E  V  +  +  ++ 
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419

Query: 741  -NSQRKQQLVELGLLREEEKQRAT--------REHEIVVNKLKAESEKMKIEL----KKT 787
               QR Q  VE  L+ + E+  A         R  + V+ + K + E+ + EL    K++
Sbjct: 1420 KTKQRLQNEVE-DLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKES 1478

Query: 788  HAAETEM---------------TLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK 832
             +  TE+               TL++ N  L+Q   + T+++A+  + I EL+     L 
Sbjct: 1479 RSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD 1538

Query: 833  EENSQQQLAAER-----------------RLQDVRQKF-------EDEKKQLIRDNDQAI 868
             E S+ Q + E                   L  V+ +        ++E  QL R++ + +
Sbjct: 1539 HEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVV 1598

Query: 869  KVLQD----ELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGL-----MPASL 919
            + +Q     E+ +R++ +R  +KK++    E + Q+ +  ++    L+ L     +    
Sbjct: 1599 ESMQSTLDAEIRSRNDALR-IKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657

Query: 920  RQELEDTI---SSLKSQVNFLQKRASILQEEL 948
            +  L+D I     LK Q+  +++RA+++Q E+
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVERRANLMQAEV 1689



 Score =  109 bits (273), Expect = 1e-23
 Identities = 138/695 (19%), Positives = 302/695 (43%), Gaps = 84/695 (12%)

Query: 231  MTPKFSLRKSSSFHDDHFLSRIREKELDMKTKM---MEAKFHE-----EKLKLQQKHDAD 282
            M  + S  K +       L R  E+E   K+ +   +++  H+     E+ + +Q+  A+
Sbjct: 1301 MVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAE 1360

Query: 283  VQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKK 342
            +Q+ + + N+E+ + +T Y +   +  E + + +KK+   ++D +   E    + A L+K
Sbjct: 1361 LQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK 1420

Query: 343  ICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQ 402
                         +++L N   E+E    D+++ +            + L+K +  +   
Sbjct: 1421 T------------KQRLQN---EVEDLMIDVERSNA---------ACIALDKKQRNF--- 1453

Query: 403  TQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTL 462
                + ++ E + + ++   E E S  + + L  E  +++  Y+ +   L+ +K     L
Sbjct: 1454 ----DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNL 1509

Query: 463  HKEKDHLVNDYEQNMKLLQ--TKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQL 520
             +E   L     +  K +    K    ++  K E   S  +A + +E  E  + +++ +L
Sbjct: 1510 QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL 1569

Query: 521  QE--SELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEAL 578
             +  SE+ RK   +D+E   Q++++HL+ + E     L +E+ + + D  +   K E  L
Sbjct: 1570 NQVKSEIDRKIAEKDEELD-QLKRNHLR-VVESMQSTLDAEI-RSRNDALRIKKKMEGDL 1626

Query: 579  KEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYA---EMKEQMEKVEADLTRS 635
             E E QL      Q  +A +     +   +  +L+ +       ++KEQ+  VE    R 
Sbjct: 1627 NEMEIQLNHANR-QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVE----RR 1681

Query: 636  KSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIE 695
             +L + + +E    LE  R    +++ E +L    E+  LL   N    +  +  E +I 
Sbjct: 1682 ANLMQAEVEELRASLE--RTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739

Query: 696  NLEKQLRAANMEHENQIQEFKK--RDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL 753
             ++ ++     E  N  ++ KK   DA ++A+   +       L  +    +Q + +L L
Sbjct: 1740 QIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL 1799

Query: 754  LREEEKQRATREHEIVVNKLKAESEKM--KIELKKTHAAETEMTLEKANSKLKQI---EK 808
              +E +Q A +  +  + KL+A   ++  ++E ++ H  E    L K   ++K++    +
Sbjct: 1800 RLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTE 1859

Query: 809  EYTQKLAKSSQIIAELQTTISSLK------EENSQQQLAAERRLQDVRQKFEDEKKQLIR 862
            E  + + +   ++ +LQT + + K      EE S   LA  R+LQ    + E+ K++   
Sbjct: 1860 EDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQ---HELEEAKER--- 1913

Query: 863  DNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQ 897
                      D  E++ N++R   +++  K +  +
Sbjct: 1914 ---------ADIAESQVNKLRVKSREVHTKVISEE 1939



 Score =  108 bits (271), Expect = 2e-23
 Identities = 171/849 (20%), Positives = 344/849 (40%), Gaps = 112/849 (13%)

Query: 104  DEPNPARAKGSSPEGLPAWVLGELETSEHKLNESWKLSSG--EDNTLVQSPTDVYSR--E 159
            +E    RA  +  E   + +  ELE    +L E+   +S   E N   ++      R  E
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183

Query: 160  QYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPR 219
            + T +    + +L   H +    +  +I  +   K  +  + S+++  +N     +E   
Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNME--- 1240

Query: 220  YLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMME-----AKFHEEKLK 274
                     ++   K +  K     +D  LS I+ KE + +  + E     A+ H E  +
Sbjct: 1241 ---------TVSKAKANFEKMCRTLEDQ-LSEIKTKEEEQQRLINELSAQKARLHTESGE 1290

Query: 275  LQQK---HDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRE 331
              ++    DA V ++   K    ++++ L R  + ET+     L   +Q+   DC ++RE
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAK-STLAHALQSARHDCDLLRE 1349

Query: 332  TKEDQIAELKKICEQSTESLNND---WEKKLHNAVAEMEQEKFDLQKQHTENIQEL---- 384
              E++  E K   ++     N++   W  K      +  +E  + +K+  + +Q+     
Sbjct: 1350 QYEEE-QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408

Query: 385  ---------LEDTNVRLNKMESEYMAQTQSTN--------------HMIKELEARVQQLT 421
                     LE T  RL     + M   + +N               ++ E + + ++  
Sbjct: 1409 EAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQ 1468

Query: 422  GEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQ 481
             E E S  + + L  E  +++  Y+ +   L+ +K     L +E   L     +  K + 
Sbjct: 1469 AELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIH 1528

Query: 482  T--KYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE--SELQRKQQLRDQENK 537
               K    ++  K E   S  +A + +E  E  + +++ +L +  SE+ RK   +D+E  
Sbjct: 1529 ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD 1588

Query: 538  FQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQ 597
             Q++++HL+ + E     L +E+ + + D  +   K E  L E E QL      Q  +A 
Sbjct: 1589 -QLKRNHLR-VVESMQSTLDAEI-RSRNDALRIKKKMEGDLNEMEIQLNHANR-QAAEAL 1644

Query: 598  QADAALEEFKRQVELNSEKVYA---EMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR 654
            +     +   +  +L+ +       ++KEQ+  VE    R  +L + + +E    LE  R
Sbjct: 1645 RNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVE----RRANLMQAEVEELRASLE--R 1698

Query: 655  QRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQE 714
                +++ E +L    E+  LL   N    +  +  E +I  ++ ++     E  N  ++
Sbjct: 1699 TERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEK 1758

Query: 715  FKKR--DAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNK 772
             KK   DA ++A+   +       L  +    +Q + +L L  +E +Q A +  +  + K
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQK 1818

Query: 773  LKAESEKMK--IELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISS 830
            L+A   +++  +E ++ H  E    L K   ++K++  +                     
Sbjct: 1819 LEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQ--------------------- 1857

Query: 831  LKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQ 890
              EE+ +  L    RLQD+  K + + K        A K   +E E +SN      +KLQ
Sbjct: 1858 -TEEDRKNIL----RLQDLVDKLQTKVK--------AYKRQAEEAEEQSNVNLAKFRKLQ 1904

Query: 891  HKELESQEQ 899
            H+  E++E+
Sbjct: 1905 HELEEAKER 1913


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score =  127 bits (319), Expect = 5e-29
 Identities = 158/719 (21%), Positives = 317/719 (44%), Gaps = 120/719 (16%)

Query: 251  RIREKELDMKTKMMEAKFHEEKL---KLQQKHDADVQKILERKNNEIEELKTLYRSKQHE 307
            R+    L+ +   + ++  +E+       Q  DA+  + L R   E++EL+T Y + + +
Sbjct: 1281 RLNSDRLESRISELTSELTDERNTGESASQLLDAETAERL-RAEKEMKELQTQYDALKKQ 1339

Query: 308  TEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEME 367
             E  + ++E     LIR  ++  E  +D                  +W  K   AV E++
Sbjct: 1340 ME--VMEMEVMEARLIRAAEINGEVDDDDAG--------------GEWRLKYERAVREVD 1383

Query: 368  QEKFDLQKQHTENIQELLEDTNVR-LNKMESEYMAQTQSTNHMIKELEARVQQLTGEAEN 426
              K  LQ++  + ++  +E  N R L +   +  A ++ +   +++L+ + Q+LT E ++
Sbjct: 1384 FTKKRLQQEFEDKLE--VEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD 1441

Query: 427  SNLQRQKLIQEKAELERCYQITCSEL-------QEVKARRNTLHKEKDHLVND------- 472
            + L  +       ELE+  +   SEL       Q  K +R  L +EKD L+ +       
Sbjct: 1442 TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1501

Query: 473  ----------YEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE 522
                      + Q +  L+ +   DI+  + +   S +K    + +LE  V   +++L E
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQ-DISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDE 1560

Query: 523  SELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKE 582
             +    Q L   + + +ME   ++  + K+      E+++ ++  QKK+ + E  L+E+ 
Sbjct: 1561 -QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY 1619

Query: 583  EQLTRV------------------------------TEVQRLQAQQADAALEEFKRQVEL 612
            E   +V                               +++R +A  ADA L     +   
Sbjct: 1620 EDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSA 1679

Query: 613  NSEKVYAEMKEQMEKVE---ADLTRSKSLREKQSKEFLWQLEDI------------RQRY 657
             S++  A++K Q+E+ E   A   +++   E + ++   Q++DI            R + 
Sbjct: 1680 PSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQR 1739

Query: 658  EQQIVELKLEHEQE-KTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFK 716
            E+  ++ +LE +QE    L+++H A      RD   +I +L+ QL  AN E + ++QE  
Sbjct: 1740 EKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD-LAQINDLQAQLEEANKE-KQELQE-- 1795

Query: 717  KRDAQVIADMEAQVHKLREELINVN--SQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
                  +  +++QV  L + +++ +  S+++ ++ EL    E E+ +  R  E + ++LK
Sbjct: 1796 -----KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKR-LESLASRLK 1849

Query: 775  AESEKMKIELKKTHAAET-----EMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTIS 829
               EK+  E  +  AAE         L++     K+   E  +K A++S+   EL+  + 
Sbjct: 1850 ENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLE 1909

Query: 830  SLKEENSQQQL---AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQD---ELENRSNQV 882
            SL+  N   Q     A +R+ D++   EDE +    +N+  I  LQD   + + R N++
Sbjct: 1910 SLEAANQSLQADLKLAFKRIGDLQAAIEDEMES--DENEDLINSLQDMVTKYQKRKNKL 1966



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 152/704 (21%), Positives = 307/704 (43%), Gaps = 109/704 (15%)

Query: 299  TLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNN---DW 355
            TL R ++   E+T R L    Q   R     +  K+ +I +L   C Q     N    DW
Sbjct: 1176 TLARLEEQRDEQTSRNLTL-FQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDW 1234

Query: 356  EK-KLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELE 414
               KL   V  + + +  L ++   N  E ++    +L K E E      +++ +   + 
Sbjct: 1235 PWWKLFTTVRPLIEVQ--LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRIS 1292

Query: 415  ARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYE 474
                +LT E        Q L  E AE  R  +    E++E++ + + L K+ + +  +  
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEK----EMKELQTQYDALKKQMEVMEMEVM 1348

Query: 475  QNMKLLQTKYDADIN--------LLKQEHALSA---------SKASSMIEELEQNVCQLK 517
            +   +   + + +++         LK E A+            +    +E  +QN  QL+
Sbjct: 1349 EARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLE 1408

Query: 518  QQLQE-----SELQRK-QQLRD---------QENKFQMEKSHLK-HIYEKKAHDLQSELD 561
            ++L +      E QR  QQL+          Q+ K  +E   ++ H  EKK     SEL 
Sbjct: 1409 RRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELS 1468

Query: 562  KGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
            +  E+ Q++  + E+  +EK+  L     +++ Q ++ D  +  F ++V ++ E    ++
Sbjct: 1469 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQ-QLEEKDMDIAGFTQKV-VSLEAELQDI 1526

Query: 622  KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNA 681
              Q  K EA L + K    KQ ++   +++D  +  ++Q   +++  EQ K  L      
Sbjct: 1527 SSQESKDEASLAKVK----KQLRDLEAKVKDQEEELDEQAGTIQML-EQAKLRL----EM 1577

Query: 682  EKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVN 741
            E + + + H +E+E+ ++++  A    + ++   K+ + Q+  + E +   LRE+     
Sbjct: 1578 EMERMRQTHSKEMESRDEEVEEARQSCQKKL---KQMEVQLEEEYEDKQKVLREK----- 1629

Query: 742  SQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEK-MKIELKKTHAAETEMTLEKAN 800
                         RE E + AT   +  VN+   ESEK ++ +LK+T A   +       
Sbjct: 1630 -------------RELEGKLATLSDQ--VNRRDFESEKRLRKDLKRTKALLADA------ 1668

Query: 801  SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENS---QQQLAAERRLQDVRQKFED-- 855
                Q+  ++ +  A S + IA+L+  +   +   +   + + A E  ++D+  + +D  
Sbjct: 1669 ----QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIA 1724

Query: 856  EKKQLIRDNDQAIKVLQDELENR--SNQVRCAEKKLQHKELESQE-----QITYIRQEYE 908
            + K  + +    ++  ++E++NR   +Q    E   +HK   +Q      QI  ++ + E
Sbjct: 1725 KAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLE 1784

Query: 909  TKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
               K       +QEL++ + +L+SQV FL++  S++ + L + Q
Sbjct: 1785 EANKE------KQELQEKLQALQSQVEFLEQ--SMVDKSLVSRQ 1820



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 91/412 (22%), Positives = 205/412 (49%), Gaps = 41/412 (9%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTL---YRSKQHETE 309
            R++E++   +  + K  + +++L+++++ D QK+L  K     +L TL      +  E+E
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYE-DKQKVLREKRELEGKLATLSDQVNRRDFESE 1651

Query: 310  ETIRKLEKKVQTLIRDCQVIRE------TKEDQIAELKKICEQS--TESLNNDWEKKLHN 361
            + +RK  K+ + L+ D Q++ +        + +IA+LK   E+S  T +      K +  
Sbjct: 1652 KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEV 1711

Query: 362  AVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLT 421
             + ++  +  D+ K  T  ++E L       N++++      +  N ++K+ +A V Q +
Sbjct: 1712 EIEDLHLQIDDIAKAKTA-LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQAS 1770

Query: 422  GE-AENSNLQRQ--KLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMK 478
             + A+ ++LQ Q  +  +EK EL+   Q   S+++ ++  ++ + K    LV+  E  ++
Sbjct: 1771 RDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLE--QSMVDKS---LVSRQEAKIR 1825

Query: 479  LLQTKYDADINLLKQEHALSASKASSM---IEELEQNV-CQLKQQLQESELQRKQQLRDQ 534
             L+T+ + +   +K+  +L++    +M    EE +Q +  + +++ Q   LQR  QLRD 
Sbjct: 1826 ELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQR--QLRDT 1883

Query: 535  ENKF------QMEKSHLKHIYEKKAHDLQSELDKGKEDTQ---KKIHKFEEALKEKEEQL 585
            + +       + E S  KH  E     L++     + D +   K+I   + A++++ E  
Sbjct: 1884 KEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESD 1943

Query: 586  TRVTEVQRLQAQQADAALEEFKRQVELNSEK-VYAEMKEQMEKVEADLTRSK 636
                 +  LQ    D   +  KR+ +L  +  V +E++++++ V++ L+++K
Sbjct: 1944 ENEDLINSLQ----DMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNK 1991



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 58/316 (18%), Positives = 128/316 (40%), Gaps = 29/316 (9%)

Query: 654  RQRYEQQIV--ELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQ 711
            RQ Y   +V  E +   +    HL ++H   ++ +V D  R +E L   L   ++E  + 
Sbjct: 1109 RQGYPDHMVFSEFRRRFDVLAPHLTKKHG--RNYIVVDERRAVEEL---LECLDLEKSSC 1163

Query: 712  IQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVN 771
                 +   +  A   A++ + R+E  + N    Q      L R+  K+R  ++  I   
Sbjct: 1164 CMGLSRVFFR--AGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCV 1221

Query: 772  KLKAESEK-----------------MKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKL 814
            +   +  K                 ++++L +      +  +++  SKL++ EKE  +  
Sbjct: 1222 QKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELR 1281

Query: 815  AKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKK-QLIRDNDQAIKVLQD 873
              S ++ + +    S L +E +  + A++    +  ++   EK+ + ++    A+K   +
Sbjct: 1282 LNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQME 1341

Query: 874  ELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLK--GLMPASLRQELEDTISSLK 931
             +E    + R       + E++  +     R +YE  ++        L+QE ED +   +
Sbjct: 1342 VMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQ 1401

Query: 932  SQVNFLQKRASILQEE 947
                 L++R   LQ +
Sbjct: 1402 QNKRQLERRLGDLQAD 1417


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  127 bits (318), Expect = 6e-29
 Identities = 181/876 (20%), Positives = 364/876 (41%), Gaps = 84/876 (9%)

Query: 126  ELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHRE---DGQN 182
            +++  E  L +  K     +N +     ++ + E+   KL     SL   H++   D Q 
Sbjct: 957  DIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV 1016

Query: 183  ITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSS 242
               K+  +    + +     D+E  L             ++K +   L   K  L     
Sbjct: 1017 EEDKVNGLIKINAKLEQQTDDLEGSLE------------QEKKLRADLERAKRKLEGDLK 1064

Query: 243  FHDDHFLSRIREK---ELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKT 299
               +  +    +K   E  +K K  E    + K+  +Q H    QK ++     IEEL+ 
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE- 1123

Query: 300  LYRSKQHETEETIR-KLEKKVQTLIRDCQVIRETKEDQIA------ELKKICEQSTESLN 352
                ++ E E T+R K+EK+   L R+ + I E  E+         E+ K  E   + + 
Sbjct: 1124 ----EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMR 1179

Query: 353  NDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLE--DTNVRL-NKMESEYMAQTQSTNHM 409
             D    L  A  + E     L+K+  +++ EL E  D   R+  K+E E        + M
Sbjct: 1180 RD----LEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235

Query: 410  IKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHL 469
               +EA  +  +           +  + KA+ E+  Q+   +L   KAR  T + E  H 
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL-IHDLNMQKARLQTQNGELSHR 1294

Query: 470  VNDYEQNMKLLQTKYDADINLLKQ-----EHALSASKASSMIEELEQNVCQLKQQLQESE 524
            V + E  +  L     A    L++     E    A  A +   +  ++ C L ++  E E
Sbjct: 1295 VEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEE 1354

Query: 525  LQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQ 584
             + K +L+   +K   E +  +  YE  A     EL++ K+   +++ + EE  +    +
Sbjct: 1355 QEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSK 1414

Query: 585  LTRVTEV-QRLQAQQADAALEEFKR---------QVELNSEKVYAEMKEQMEKVEADLTR 634
               + +  QRLQ +  D  + + +R         + + N +KV AE K+++++ +A+L  
Sbjct: 1415 CASLEKTKQRLQGEVED-LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEA 1473

Query: 635  SKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREI 694
            +    +K+S+    +L  +R  YE+ + +L+    + K   LQ+  ++    + +  + +
Sbjct: 1474 A----QKESRSLSTELFKMRNAYEEVVDQLETLRRENKN--LQEEISDLTEQIAETGKNL 1527

Query: 695  ENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLL 754
            +  EK  +    E ++ +Q   +     +   E+++ +++ EL  V S+  ++++E    
Sbjct: 1528 QEAEKTKKLVEQE-KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586

Query: 755  REEEKQRATREHEIVVNKLKAE--SEKMKIELKKTHAAE-TEMTLEKANSKLKQIEKEYT 811
             E+ K+ + R  E + + L AE  S    + LKK    +  EM ++  +S  +  E +  
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKH 1646

Query: 812  QKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVL 871
             +  +     ++L    +    E+ ++QLA   R   +  +  +E K  +   ++  ++ 
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706

Query: 872  QDELENRSNQVRC----------AEKKLQHKELESQEQITYIRQE---YETKLK------ 912
            + EL + S++V+            +KKL+    + Q ++    QE    E K K      
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766

Query: 913  GLMPASLRQELEDTISSLKSQVNFLQKRASILQEEL 948
             +M   L++E +DT + L+     L++    LQ  L
Sbjct: 1767 AMMAEELKKE-QDTSAHLERMKKNLEQTVKDLQHRL 1801



 Score =  112 bits (280), Expect = 2e-24
 Identities = 158/697 (22%), Positives = 312/697 (44%), Gaps = 81/697 (11%)

Query: 318  KVQTLIRDCQVIRETKEDQIAELKKICEQSTESL--NNDWEKKLHNAVAEMEQEKFDLQK 375
            K++ L++  +      E ++A +K+  E++ E L  +    K+L   +  + QEK DLQ 
Sbjct: 839  KIKPLLKSAEA-----EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893

Query: 376  Q---HTENIQELLE------DTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAEN 426
            Q    TEN+ +  E       + + L     E   + +    M  EL A+ + L  E + 
Sbjct: 894  QVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL--EDKC 951

Query: 427  SNLQRQ---------KLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNM 477
            S+L+R          K+ +EK   E   +    E+  ++   + L KEK  L   ++Q +
Sbjct: 952  SSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTL 1011

Query: 478  KLLQTKYDADINLLK-----QEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLR 532
              LQ + D    L+K     ++       +    ++L  ++ + K++L+      ++ + 
Sbjct: 1012 DDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIM 1071

Query: 533  DQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDT---QKKIHKFEEALKEKEEQL-TRV 588
            D EN  Q  +  LK   E +   LQ+++D  +  +   QKKI + +  ++E EE++    
Sbjct: 1072 DLENDKQQIEEKLKK-KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130

Query: 589  TEVQRLQAQQADAA--LEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEF 646
            T   +++ Q++D A  LEE   ++E  S    A++ E  +K EA+  + +   E+ + + 
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQI-EMNKKREAEFQKMRRDLEEATLQH 1189

Query: 647  LWQLEDIRQRYEQQIVEL--KLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAA 704
                  +R++    + EL  ++++ Q     L++  +E    + D    IE L K    +
Sbjct: 1190 EATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS--KS 1247

Query: 705  NMEH-----ENQIQEFKKRD---AQVIADMEAQVHKL-------------REELINVNSQ 743
            N+E      E+Q  E K +D    Q+I D+  Q  +L             +E LI+  ++
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307

Query: 744  RK----QQLVELGLLREEE-KQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEK 798
             K    QQL EL    EEE K +    H +  ++   +  + + E ++   AE +  L K
Sbjct: 1308 SKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367

Query: 799  ANSKLKQIEKEYTQKLAKSSQIIAELQTTISSL---KEENSQQQLAAERRLQDVRQKFED 855
            ANS++ Q   +Y     + ++ + E +  ++      EEN++   +    L+  +Q+ + 
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQG 1427

Query: 856  EKKQLIRDNDQ---AIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLK 912
            E + L+RD ++   A   L  +  N    +   ++KL     ESQ ++   ++E  +   
Sbjct: 1428 EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD----ESQAELEAAQKESRSLST 1483

Query: 913  GLMP-ASLRQELEDTISSLKSQVNFLQKRASILQEEL 948
             L    +  +E+ D + +L+ +   LQ+  S L E++
Sbjct: 1484 ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI 1520



 Score =  107 bits (267), Expect = 5e-23
 Identities = 165/782 (21%), Positives = 332/782 (42%), Gaps = 125/782 (15%)

Query: 249  LSRIREKELD-MKTKMMEAKF-HEEKLKLQQKHDAD-VQKI------LERKNNEIEELKT 299
            +++ RE E   M+  + EA   HE      +K  AD V ++      L+R   ++E+ K+
Sbjct: 1167 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKS 1226

Query: 300  LYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKL 359
              + +  +    I  L K    + R C+ +    EDQ +E+K   EQ T+ ++       
Sbjct: 1227 ELKMEIDDMASNIEALSKSKSNIERTCRTV----EDQFSEIKAKDEQQTQLIH------- 1275

Query: 360  HNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELE----- 414
                 ++  +K  LQ Q+ E +   +E+    ++++     A TQ    + +++E     
Sbjct: 1276 -----DLNMQKARLQTQNGE-LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKA 1329

Query: 415  --ARVQQLTGEAENSNLQRQKLIQE---KAELERCYQITCSELQEVKARRNTLHKEKDHL 469
              A    L     + +L R++  +E   KAEL+R      SE+ +               
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQ--------------- 1374

Query: 470  VNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQ 529
                       +TKY+ D     +E   +  K +  ++E E+N      +    E + KQ
Sbjct: 1375 ----------WRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE-KTKQ 1423

Query: 530  QLRDQENKF--QMEKSHLK-HIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLT 586
            +L+ +       +E+SH      +KK  +    L + K+   +   + E A KE     T
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483

Query: 587  RVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADL---TRSKSLREKQS 643
             + +++    +  D  LE  +R+   N ++  +++ EQ+ +   +L    ++K L E++ 
Sbjct: 1484 ELFKMRNAYEEVVD-QLETLRRE-NKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK 1541

Query: 644  KEFLWQLEDIR---QRYEQQIVELKLEHEQEKTHL---LQQHNAEKDSLVRDHEREIENL 697
             +    LE++    +  E +I+ ++LE  Q K+ L   + + + E + L R+ +R  E L
Sbjct: 1542 SDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEAL 1601

Query: 698  EKQLRAANMEHENQIQEFKKRDAQVIADMEAQV-HKLRE------ELINVNSQRKQQLVE 750
            +  L  A +   N     KK+    + +ME Q+ H  R+       L  V  Q K   + 
Sbjct: 1602 QSVL-DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLH 1660

Query: 751  L-GLLREEEKQRATREHEIVVNK----LKAESEKMKIELKKTHAAE--TEMTLEKANSKL 803
            L   LR  E     +E   +V +    L  E E+MK+ L++T      +E  L  A+ ++
Sbjct: 1661 LDDALRSNED---LKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV 1717

Query: 804  KQIEKEYTQKLAKSSQI---IAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQ- 859
            + +  + T  +    ++   IA+ Q  + +  +E+   +  A++ + D     E+ KK+ 
Sbjct: 1718 QLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ 1777

Query: 860  --------LIRDNDQAIKVLQDELENRSN-QVRCAEKKLQH-----KELESQEQITYIR- 904
                    + ++ +Q +K LQ  L+      ++  +K++Q      +ELE++  +   R 
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRG 1837

Query: 905  -------QEYETKLKGLMPASLRQ-----ELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
                    +YE K+K +   +         L+D +  L+++V   +++A   +E+  T  
Sbjct: 1838 AEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQL 1897

Query: 953  GR 954
             R
Sbjct: 1898 SR 1899



 Score =  103 bits (258), Expect = 6e-22
 Identities = 152/704 (21%), Positives = 300/704 (42%), Gaps = 111/704 (15%)

Query: 249  LSRIREKELDMKTKM---MEAKFHE-----EKLKLQQKHDADVQKILERKNNEIEELKTL 300
            L R  E+E   K  M   +++  H+     E+ + +Q+  A++Q+ L + N+E+ + +T 
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378

Query: 301  YRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQ---STESLNNDWEK 357
            Y +   +  E + + +KK+   +++ +   ET   + A L+K  ++     E L  D E+
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438

Query: 358  KLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARV 417
              H A A +++++ +  K   E  Q+ L+++   L   + E  + +     M    E  V
Sbjct: 1439 S-HTACATLDKKQRNFDKVLAEWKQK-LDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496

Query: 418  QQL-TGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQN 476
             QL T   EN NLQ     +E ++L      T   LQE +  +  + +EK          
Sbjct: 1497 DQLETLRRENKNLQ-----EEISDLTEQIAETGKNLQEAEKTKKLVEQEK---------- 1541

Query: 477  MKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQEN 536
                     +D+ +  +E   S     S I  ++  + Q+K     SEL RK   +D+E 
Sbjct: 1542 ---------SDLQVALEEVEGSLEHEESKILRVQLELSQVK-----SELDRKVIEKDEEI 1587

Query: 537  KFQMEKSHLKHIYEKKAHDLQSELD---KGKEDTQKKIHKFEEALKEKEEQLTRVTEVQR 593
            +       LK   ++ A  LQS LD   + + D  +   K E  L E E QL        
Sbjct: 1588 E------QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLG------- 1634

Query: 594  LQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDI 653
              + +  A  ++  R V+   +     + + +   E DL    ++ E+++   L +LE++
Sbjct: 1635 -HSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE-DLKEQLAIVERRNGLLLEELEEM 1692

Query: 654  RQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQ 713
            +   EQ           E+T  L              E+E+ +   +++  + ++ + I 
Sbjct: 1693 KVALEQ----------TERTRRLS-------------EQELLDASDRVQLLHSQNTSLIN 1729

Query: 714  EFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKL 773
              KK +A  IA  +A+V    +E  N   + K+ + +  ++ EE K+             
Sbjct: 1730 TKKKLEAD-IAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKE---------QDT 1779

Query: 774  KAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKE 833
             A  E+MK  L++T   + +  L++A     +  K+  QKL      + EL+  +   ++
Sbjct: 1780 SAHLERMKKNLEQT-VKDLQHRLDEAEQLALKGGKKQIQKLENR---VRELENELDVEQK 1835

Query: 834  ENSQQQLAA---ERRLQDVRQKFEDEKKQLIRDND---------QAIKVLQDELENRSNQ 881
              ++    A   ER+++++  + E++ K ++R  D         ++ K   +E E ++N 
Sbjct: 1836 RGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895

Query: 882  VRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELED 925
                 +++QH ELE   +   I +    KL+        Q++E+
Sbjct: 1896 QLSRCRRVQH-ELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  126 bits (316), Expect = 1e-28
 Identities = 176/864 (20%), Positives = 368/864 (42%), Gaps = 146/864 (16%)

Query: 220  YLRQKPIPVSLMTPKFSLRKSSSFHDD-HFLSRIREKELDMKTKMMEAKFHEEKLKLQQK 278
            Y + KP+  S  T K        F      L++   K  +++ KM+     +  L+LQ +
Sbjct: 837  YFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896

Query: 279  HDADVQKILERKNNEIEELKTLYRSKQHET-------EETIRKLEKKVQTLIRDCQVIRE 331
             +AD     E + +++ + K    +K  E        EE   +L  K + L  +C  +++
Sbjct: 897  AEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 956

Query: 332  TKED---QIAELKKICEQSTESLNNDWEKK--LHNAVAEMEQEKFDLQKQHTENIQEL-- 384
              +D    +A+++K    +   + N  E+   L   +A++ +EK  LQ+ H + + +L  
Sbjct: 957  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1016

Query: 385  -------LEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQE 437
                   L    ++L +   +     +    +  +LE   ++L G+ + +      +  +
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEND 1076

Query: 438  KAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHAL 497
            K +L+   +    E+  ++++     +++  L    ++ +K LQ + +     ++ E A 
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSK----IEDEQALGMQLQKKIKELQARIEELEEEIEAERA- 1131

Query: 498  SASKASSMIEELEQNVCQLKQQLQES--------ELQRKQQLRDQENKFQMEKSHLKH-- 547
            S +KA     +L + + ++ ++L+E+        E+ +K++   Q+ +  +E++ L+H  
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191

Query: 548  ---IYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEV--QRLQAQQADAA 602
                  KK  D  +EL +  ++ Q+   K E   KEK E    + ++        +A   
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKLE---KEKSEMKMEIDDLASNMETVSKAKGN 1248

Query: 603  LEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDI--------- 653
            LE+  R +E    ++  + +EQ   +  DLT  ++  + +S E+  QL++          
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLIN-DLTAQRARLQTESGEYSRQLDEKDTLVSQLSR 1307

Query: 654  -RQRYEQQIVELKLEHEQE------KTHLLQQHNAEKDSLVRDHEREIE---NLEKQLRA 703
             +Q + QQI ELK + E+E        H LQ    + D L   +E E E    L++ +  
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367

Query: 704  ANME--------------HENQIQEFKKRDAQVIADMEAQVHKLREELINV--NSQRKQQ 747
            AN E                 +++E KK+ AQ + D E  V  +  +  ++    QR Q 
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427

Query: 748  LVELGLLREEEKQRAT--------REHEIVVNKLKAESEKMKIEL----KKTHAAETEM- 794
             VE  L+ + E+  A         R  + ++ + K + E+   EL    K++ +  TE+ 
Sbjct: 1428 EVE-DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486

Query: 795  --------------TLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQL 840
                          TL++ N  L+Q   + T+++A+  + I EL+     +++E S+ Q 
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546

Query: 841  AAE----------------------------RRLQDVRQKFEDEKKQLIRDNDQAIKVLQ 872
            A E                            R++ +  ++ +  K+  IR  +     L 
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD 1606

Query: 873  DELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKG-----LMPASLRQELEDTI 927
             E+ +R++ +R  +KK++    E + Q+ +  +     L+       +    +  L+D +
Sbjct: 1607 AEIRSRNDAIR-LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665

Query: 928  SS---LKSQVNFLQKRASILQEEL 948
             S   LK Q+  +++RA++LQ E+
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEI 1689



 Score =  108 bits (269), Expect = 3e-23
 Identities = 137/703 (19%), Positives = 305/703 (43%), Gaps = 88/703 (12%)

Query: 213  LGIENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKM---MEAKFH 269
            L  E+  Y RQ     +L++ + S  K +       L R  E+E+  K+ +   +++  H
Sbjct: 1284 LQTESGEYSRQLDEKDTLVS-QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRH 1342

Query: 270  E-----EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIR 324
            +     E+ + +Q+  A++Q+ + + N+E+ + +T Y +   +  E + + +KK+   ++
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1402

Query: 325  DCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQEL 384
            D                   E+  E++N           A +E+ K  LQ +    +++L
Sbjct: 1403 D------------------AEEHVEAVN--------AKCASLEKTKQRLQNE----VEDL 1432

Query: 385  LEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERC 444
            + D   R N   +    + ++ + ++ E + + ++   E E S  + + L  E  +++  
Sbjct: 1433 MIDVE-RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNA 1491

Query: 445  YQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQ--TKYDADINLLKQEHALSASKA 502
            Y+ +  +L+ +K     L +E   L     +  K +    K    +   K E   +  +A
Sbjct: 1492 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEA 1551

Query: 503  SSMIEELEQNVCQLKQQLQE--SELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSEL 560
             + +E  E  + +++ +L +  SE+ RK   +D+E   QM+++H++ I E     L +E+
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID-QMKRNHIR-IVESMQSTLDAEI 1609

Query: 561  DKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAE 620
             + + D  +   K E  L E E QL           + A  AL  ++     N++ +  +
Sbjct: 1610 -RSRNDAIRLKKKMEGDLNEMEIQLNHAN-------RMAAEALRNYR-----NTQAILKD 1656

Query: 621  MKEQME---KVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQ-----QIVELKLEHEQEK 672
             +  ++   + + DL    ++ E+++     ++E++R   EQ     +I E +L    E+
Sbjct: 1657 TQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASER 1716

Query: 673  THLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKK--RDAQVIADMEAQV 730
              LL   N    +  +  E +I  ++ ++     E  N  ++ KK   DA ++A+   + 
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKE 1776

Query: 731  HKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM--KIELKKTH 788
                  L  +    +Q + +L    +E +Q A +  +  + KL+A   ++  ++E ++  
Sbjct: 1777 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1836

Query: 789  AAETEMTLEKANSKLKQI---EKEYTQKLAKSSQIIAELQTTISSLK------EENSQQQ 839
              E    L K   K+K++    +E  + + +   ++ +LQ  + S K      EE S   
Sbjct: 1837 NVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVN 1896

Query: 840  LAAERRLQDVRQKFEDE--------KKQLIRDNDQAIKVLQDE 874
            L+  RR+Q   ++ E+          K  ++  +   K++ +E
Sbjct: 1897 LSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  126 bits (316), Expect = 1e-28
 Identities = 175/756 (23%), Positives = 340/756 (44%), Gaps = 133/756 (17%)

Query: 266  AKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRD 325
            AK  +EK  LQ+ H    Q+ L+    E +++ TL ++K         KLE++V  L   
Sbjct: 996  AKLTKEKKALQEAH----QQTLDDLQAEEDKVNTLTKAKI--------KLEQQVDDL--- 1040

Query: 326  CQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELL 385
                 E   +Q  +L+   E++   L  D  K    ++ ++E EK  L ++  +   E+ 
Sbjct: 1041 -----EGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENEKQQLDEKLKKKEFEI- 1093

Query: 386  EDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
              +N++ +K+E E     Q     IKEL+AR+++L  E E     R K  +++++L R  
Sbjct: 1094 --SNLQ-SKIEDEQALGIQ-LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149

Query: 446  QITCSELQEVKARRNT---LHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKA 502
            +     L+E     +    ++K+++       ++++    +++A    L+++HA S ++ 
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209

Query: 503  SSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELD- 561
               I+ L+    ++KQ+L++ + + K ++ D  +  +   S  K   EK    L+ +L  
Sbjct: 1210 GEQIDNLQ----RVKQKLEKEKSEMKMEIDDLASNVE-TVSKAKGNLEKMCRTLEDQLSE 1264

Query: 562  -KGKEDTQKKI---------------HKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
             K KE+ Q+++                +F   L EKE  +++++  ++   QQ    +EE
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQ----IEE 1320

Query: 606  FKRQV--ELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFL--------WQLEDIRQ 655
             KRQ+  E+ ++   A    Q  + + DL R +   E++SK  L         ++   R 
Sbjct: 1321 LKRQLEEEIKAKNALAHAL-QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379

Query: 656  RYEQQIVELKLEHEQEKTHLLQ------QH----NAEKDSLVRDHER---EIENLEKQLR 702
            +YE   ++   E E+ K  L Q      +H    NA+  SL +  +R   E+E+L   + 
Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439

Query: 703  AAN----------MEHENQIQEFKKRDAQVIADMEA---QVHKLREELINVNSQRKQQLV 749
              N             +  + E+K++  +  A++EA   +   L  EL  + +  ++ L 
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499

Query: 750  ELGLLREEEK--------------QRATREHEIVVNKLKAESEKMKIELKKTHAAETEMT 795
            +L  L+ E K              +   R HE+   K+K + E+ K EL+     E E +
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHEL--EKIKKQVEQEKCELQAA-LEEAEAS 1556

Query: 796  LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFED 855
            LE    K+ +I+ E  Q  ++  + IAE    I  LK  +        R ++ ++   + 
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI-------RIVESMQSTLDA 1609

Query: 856  EKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM 915
            E    IR  + AI+ L+ ++E   N++   E +L H    + E +   R       +G++
Sbjct: 1610 E----IRSRNDAIR-LKKKMEGDLNEM---EIQLNHANRMAAEALRNYR-----NTQGIL 1656

Query: 916  PASLRQELEDTISS---LKSQVNFLQKRASILQEEL 948
                +  L+D + S   LK Q+  +++RA++LQ E+
Sbjct: 1657 -KDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691



 Score =  113 bits (282), Expect = 1e-24
 Identities = 160/734 (21%), Positives = 335/734 (45%), Gaps = 94/734 (12%)

Query: 252  IREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEET 311
            ++  E + +   M+ +F + K +L +          E K  E+EE       ++++ +  
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKS---------EAKRKELEEKMVTLLKEKNDLQLQ 896

Query: 312  IRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKF 371
            ++   + +      C  + +TK    A++K++ E++ +      E++++   AE+  +K 
Sbjct: 897  VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAED------EEEIN---AELTAKKR 947

Query: 372  DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQR 431
             L+ + +E +++ ++D  + L K+E E  A            E +V+ LT E    +   
Sbjct: 948  KLEDECSE-LKKDIDDLELTLAKVEKEKHA-----------TENKVKNLTEEMAGLDETI 995

Query: 432  QKLIQEKAELERCYQITCSELQEVKARRNTLHKEK---DHLVNDYEQNMKLLQTKYDADI 488
             KL +EK  L+  +Q T  +LQ  + + NTL K K   +  V+D E +++  + K   D+
Sbjct: 996  AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE-QEKKLRMDL 1054

Query: 489  NLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHI 548
               K++       A   I ++E      KQQL E   +++ ++ + ++K + E++ L   
Sbjct: 1055 ERAKRKLEGDLKLAQESIMDIENE----KQQLDEKLKKKEFEISNLQSKIEDEQA-LGIQ 1109

Query: 549  YEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEV-QRL-QAQQADAALEEF 606
             +KK  +LQ+ +++ +E+ + +     +A K++ +    + E+ +RL +A  A +A  E 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169

Query: 607  KRQVELNSEKVYAEMKE---QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE 663
             ++ E   +K+  +++E   Q E   A L +  +    +  E +  L+ ++Q+ E++  E
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229

Query: 664  LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQ-- 721
            +K+E +   +      N E  S  +       NLEK  R      E+Q+ E K ++ +  
Sbjct: 1230 MKMEIDDLAS------NVETVSKAKG------NLEKMCRTL----EDQLSELKSKEEEQQ 1273

Query: 722  -VIADMEAQVHKL-------------REELINVNSQRK----QQLVEL-GLLREEEKQRA 762
             +I D+ AQ  +L             +E L++  S+ K    QQ+ EL   L EE K + 
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKN 1333

Query: 763  TREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA 822
               H +  ++   +  + + E ++   AE +  L KAN+++ Q   +Y     + ++ + 
Sbjct: 1334 ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393

Query: 823  ELQTTIS---SLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRD---NDQAIKVLQDELE 876
            E +  ++      EE+ +   A    L+  +Q+ ++E + L+ D    + A   L  +  
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453

Query: 877  NRSNQVRCAEKKLQ--HKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV 934
            N    +   ++K +  H ELE+ ++          K+K     SL     D + +LK + 
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL-----DQLETLKREN 1508

Query: 935  NFLQKRASILQEEL 948
              LQ+  S L E++
Sbjct: 1509 KNLQQEISDLTEQI 1522



 Score =  109 bits (272), Expect = 1e-23
 Identities = 144/735 (19%), Positives = 319/735 (43%), Gaps = 90/735 (12%)

Query: 181  QNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKS 240
            + +  ++ E+ SK+       +D+ A+     L  E+  + RQ     +L++ + S  K 
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRG--RLQTESGEFSRQLDEKEALVS-QLSRGKQ 1312

Query: 241  SSFHDDHFLSRIREKELDMKTKM---MEAKFHE-----EKLKLQQKHDADVQKILERKNN 292
            +       L R  E+E+  K  +   +++  H+     E+ + +Q+  A++Q+ L + N 
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372

Query: 293  EIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLN 352
            E+ + +T Y +   +  E + + +KK                  +A+  +  E+  E++N
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKK------------------LAQRLQAAEEHVEAVN 1414

Query: 353  NDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKE 412
                       A +E+ K  LQ +    +++L+ D   R N   +    + ++ + ++ E
Sbjct: 1415 --------AKCASLEKTKQRLQNE----VEDLMLDVE-RTNAACAALDKKQRNFDKILAE 1461

Query: 413  LEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVND 472
             + + ++   E E S  + + L  E  +++  Y+ +  +L+ +K     L +E   L   
Sbjct: 1462 WKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ 1521

Query: 473  YEQNMKLLQ--TKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE--SELQRK 528
              +  K +    K    +   K E   +  +A + +E  E  + +++ +L +  SE+ RK
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581

Query: 529  QQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRV 588
               +D+E   Q++++H++ I E     L +E+ + + D  +   K E  L E E QL   
Sbjct: 1582 IAEKDEEID-QLKRNHIR-IVESMQSTLDAEI-RSRNDAIRLKKKMEGDLNEMEIQLNHA 1638

Query: 589  TEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQME---KVEADLTRSKSLREKQSKE 645
                    + A  AL  ++     N++ +  + +  ++   + + DL    ++ E+++  
Sbjct: 1639 N-------RMAAEALRNYR-----NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686

Query: 646  FLWQLEDIRQRYEQ-----QIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQ 700
               ++E++R   EQ     +I E +L    E+  LL   N    +  +  E +I  ++ +
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGE 1746

Query: 701  LRAANMEHENQIQEFKK--RDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEE 758
            +     E  N  ++ KK   DA ++A+   +       L  +    +Q + +L L  +E 
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806

Query: 759  KQRATREHEIVVNKLKAESEKM--KIELKKTHAAETEMTLEKANSKLKQI---EKEYTQK 813
            +Q A +  +  + KL+A   ++  ++E ++   AE    L K   ++K++    +E  + 
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866

Query: 814  LAKSSQIIAELQTTISSLK------EENSQQQLAAERRLQDVRQKFEDE--------KKQ 859
            + +   ++ +LQ  + S K      EE S   LA  R+LQ   ++ E+          K 
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926

Query: 860  LIRDNDQAIKVLQDE 874
             ++  +   KV+ +E
Sbjct: 1927 RVKSREVHTKVISEE 1941



 Score =  106 bits (264), Expect = 1e-22
 Identities = 161/841 (19%), Positives = 360/841 (42%), Gaps = 96/841 (11%)

Query: 104  DEPNPARAKGSSPEGLPAWVLGELETSEHKLNESWKLSSG--EDNTLVQSPTDVYSR--E 159
            +E    RA  +  E   + +  ELE    +L E+   +S   E N   ++      R  E
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185

Query: 160  QYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPR 219
            + T +    + +L   H +    +  +I  +   K  +  + S+++  ++     +E   
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE--- 1242

Query: 220  YLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKH 279
                     ++   K +L K     +D  LS ++ KE + +  + +      +L   Q  
Sbjct: 1243 ---------TVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRL---QTE 1289

Query: 280  DADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKV----------QTLIRDCQVI 329
              +  + L+ K   + +L    ++   + EE  R+LE+++          Q+   DC ++
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349

Query: 330  RETKEDQIAELKKICEQSTESLNND---WEKKLHNAVAEMEQEKFDLQKQHTENIQ---E 383
            RE  E++  E K   +++    N +   W  K      +  +E  + +K+  + +Q   E
Sbjct: 1350 REQYEEE-QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408

Query: 384  LLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELER 443
             +E  N +   +E       Q   + +++L   V++        + +++   +  AE ++
Sbjct: 1409 HVEAVNAKCASLEKT----KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ 1464

Query: 444  CYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSA--SK 501
              + T +EL+  +    +L  E   + N YE+++  L+T    + NL ++   L+   ++
Sbjct: 1465 KCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1524

Query: 502  ASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELD 561
                I ELE+    +K+Q+++ + + +  L + E   + E+  +  I        Q EL+
Sbjct: 1525 GGKRIHELEK----IKKQVEQEKCELQAALEEAEASLEHEEGKILRI--------QLELN 1572

Query: 562  KGKEDTQKKIHKFEEALKEKEEQLTRVTEVQR--LQAQ---QADAALEEFKRQVELNSEK 616
            + K +  +KI + +E + + +    R+ E  +  L A+   + DA   + K + +LN  +
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632

Query: 617  VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLL 676
            +      +M    A+  R+    +   K+    L+D  +   Q+ ++ +L   + + +LL
Sbjct: 1633 IQLNHANRMA---AEALRNYRNTQGILKDTQIHLDDALR--SQEDLKEQLAMVERRANLL 1687

Query: 677  QQHNAEKDSLVRDHEREIENLEKQLRAANME------HENQIQEFKKRDAQVIADMEAQV 730
            Q    E  + +   ER  +  E++L  A+            +   KK+    I+ M+ ++
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747

Query: 731  HKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAA 790
              + +E  N   + K+ + +  ++ EE K+              A  E+MK  +++T   
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEELKKE---------QDTSAHLERMKKNMEQT-VK 1797

Query: 791  ETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAA---ERRLQ 847
            + ++ L++A     +  K+  QKL      + EL+  + S ++ N++        ERR++
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKLEAR---VRELEGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 848  DVRQKFEDEKKQLIRDND---------QAIKVLQDELENRSNQVRCAEKKLQHKELESQE 898
            ++  + E+++K ++R  D         ++ K   +E E +SN      +KLQH+  E++E
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914

Query: 899  Q 899
            +
Sbjct: 1915 R 1915



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 102/481 (21%), Positives = 218/481 (45%), Gaps = 77/481 (16%)

Query: 515  QLKQQLQESELQRKQQLRDQEN---KFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKI 571
            ++K  L+ +E +++     +E    K ++ KS  K    K+  +    L K K D Q ++
Sbjct: 841  KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKR---KELEEKMVTLLKEKNDLQLQV 897

Query: 572  HKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSE-KVYAEMKEQMEKVEA 630
                E L + EE+  ++                  K +++L ++ K   E  E  E++ A
Sbjct: 898  QAEAEGLADAEERCDQL-----------------IKTKIQLEAKIKEVTERAEDEEEINA 940

Query: 631  DLTRSKSLREKQSKEFLWQLEDI-----RQRYEQQIVELKLEHEQEKTHLLQQHNA---- 681
            +LT  K   E +  E    ++D+     +   E+   E K+++  E+   L +  A    
Sbjct: 941  ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 1000

Query: 682  EKDSLVRDHEREIENLEKQ------LRAANMEHENQIQEFK---KRDAQVIADMEAQVHK 732
            EK +L   H++ +++L+ +      L  A ++ E Q+ + +   +++ ++  D+E    K
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1060

Query: 733  L-------REELINVNSQRKQQLVELGLLRE----------EEKQRATREHEIVVNKLKA 775
            L       +E ++++ ++ KQQL E    +E          E++Q    + +  + +L+A
Sbjct: 1061 LEGDLKLAQESIMDIENE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119

Query: 776  ESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEEN 835
              E+++ E++   A+  +   EK  S L +  +E +++L ++       Q  ++  +E  
Sbjct: 1120 RIEELEEEIEAERASRAK--AEKQRSDLSRELEEISERLEEAGG-ATSAQIEMNKKREAE 1176

Query: 836  SQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELE 895
             Q+     R L++   + E     L + +  ++  L ++++N    ++  ++KL+ ++ E
Sbjct: 1177 FQKM---RRDLEEATLQHEATAATLRKKHADSVAELGEQIDN----LQRVKQKLEKEKSE 1229

Query: 896  SQEQITYIRQEYET--KLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQG 953
             + +I  +    ET  K KG +    R  LED +S LKS+    Q+    L  +LT  +G
Sbjct: 1230 MKMEIDDLASNVETVSKAKGNLEKMCR-TLEDQLSELKSKEEEQQR----LINDLTAQRG 1284

Query: 954  R 954
            R
Sbjct: 1285 R 1285


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  126 bits (316), Expect = 1e-28
 Identities = 175/756 (23%), Positives = 340/756 (44%), Gaps = 133/756 (17%)

Query: 266  AKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRD 325
            AK  +EK  LQ+ H    Q+ L+    E +++ TL ++K         KLE++V  L   
Sbjct: 996  AKLTKEKKALQEAH----QQTLDDLQAEEDKVNTLTKAKI--------KLEQQVDDL--- 1040

Query: 326  CQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELL 385
                 E   +Q  +L+   E++   L  D  K    ++ ++E EK  L ++  +   E+ 
Sbjct: 1041 -----EGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENEKQQLDEKLKKKEFEI- 1093

Query: 386  EDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
              +N++ +K+E E     Q     IKEL+AR+++L  E E     R K  +++++L R  
Sbjct: 1094 --SNLQ-SKIEDEQALGIQ-LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149

Query: 446  QITCSELQEVKARRNT---LHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKA 502
            +     L+E     +    ++K+++       ++++    +++A    L+++HA S ++ 
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209

Query: 503  SSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELD- 561
               I+ L+    ++KQ+L++ + + K ++ D  +  +   S  K   EK    L+ +L  
Sbjct: 1210 GEQIDNLQ----RVKQKLEKEKSEMKMEIDDLASNVE-TVSKAKGNLEKMCRTLEDQLSE 1264

Query: 562  -KGKEDTQKKI---------------HKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
             K KE+ Q+++                +F   L EKE  +++++  ++   QQ    +EE
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQ----IEE 1320

Query: 606  FKRQV--ELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFL--------WQLEDIRQ 655
             KRQ+  E+ ++   A    Q  + + DL R +   E++SK  L         ++   R 
Sbjct: 1321 LKRQLEEEIKAKNALAHAL-QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379

Query: 656  RYEQQIVELKLEHEQEKTHLLQ------QH----NAEKDSLVRDHER---EIENLEKQLR 702
            +YE   ++   E E+ K  L Q      +H    NA+  SL +  +R   E+E+L   + 
Sbjct: 1380 KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439

Query: 703  AAN----------MEHENQIQEFKKRDAQVIADMEA---QVHKLREELINVNSQRKQQLV 749
              N             +  + E+K++  +  A++EA   +   L  EL  + +  ++ L 
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499

Query: 750  ELGLLREEEK--------------QRATREHEIVVNKLKAESEKMKIELKKTHAAETEMT 795
            +L  L+ E K              +   R HE+   K+K + E+ K EL+     E E +
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHEL--EKIKKQVEQEKCELQAA-LEEAEAS 1556

Query: 796  LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFED 855
            LE    K+ +I+ E  Q  ++  + IAE    I  LK  +        R ++ ++   + 
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI-------RIVESMQSTLDA 1609

Query: 856  EKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM 915
            E    IR  + AI+ L+ ++E   N++   E +L H    + E +   R       +G++
Sbjct: 1610 E----IRSRNDAIR-LKKKMEGDLNEM---EIQLNHANRMAAEALRNYR-----NTQGIL 1656

Query: 916  PASLRQELEDTISS---LKSQVNFLQKRASILQEEL 948
                +  L+D + S   LK Q+  +++RA++LQ E+
Sbjct: 1657 -KDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691



 Score =  113 bits (282), Expect = 1e-24
 Identities = 160/734 (21%), Positives = 335/734 (45%), Gaps = 94/734 (12%)

Query: 252  IREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEET 311
            ++  E + +   M+ +F + K +L +          E K  E+EE       ++++ +  
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKS---------EAKRKELEEKMVTLLKEKNDLQLQ 896

Query: 312  IRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKF 371
            ++   + +      C  + +TK    A++K++ E++ +      E++++   AE+  +K 
Sbjct: 897  VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAED------EEEIN---AELTAKKR 947

Query: 372  DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQR 431
             L+ + +E +++ ++D  + L K+E E  A            E +V+ LT E    +   
Sbjct: 948  KLEDECSE-LKKDIDDLELTLAKVEKEKHA-----------TENKVKNLTEEMAGLDETI 995

Query: 432  QKLIQEKAELERCYQITCSELQEVKARRNTLHKEK---DHLVNDYEQNMKLLQTKYDADI 488
             KL +EK  L+  +Q T  +LQ  + + NTL K K   +  V+D E +++  + K   D+
Sbjct: 996  AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE-QEKKLRMDL 1054

Query: 489  NLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHI 548
               K++       A   I ++E      KQQL E   +++ ++ + ++K + E++ L   
Sbjct: 1055 ERAKRKLEGDLKLAQESIMDIENE----KQQLDEKLKKKEFEISNLQSKIEDEQA-LGIQ 1109

Query: 549  YEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEV-QRL-QAQQADAALEEF 606
             +KK  +LQ+ +++ +E+ + +     +A K++ +    + E+ +RL +A  A +A  E 
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169

Query: 607  KRQVELNSEKVYAEMKE---QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE 663
             ++ E   +K+  +++E   Q E   A L +  +    +  E +  L+ ++Q+ E++  E
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229

Query: 664  LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQ-- 721
            +K+E +   +      N E  S  +       NLEK  R      E+Q+ E K ++ +  
Sbjct: 1230 MKMEIDDLAS------NVETVSKAKG------NLEKMCRTL----EDQLSELKSKEEEQQ 1273

Query: 722  -VIADMEAQVHKL-------------REELINVNSQRK----QQLVEL-GLLREEEKQRA 762
             +I D+ AQ  +L             +E L++  S+ K    QQ+ EL   L EE K + 
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKN 1333

Query: 763  TREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA 822
               H +  ++   +  + + E ++   AE +  L KAN+++ Q   +Y     + ++ + 
Sbjct: 1334 ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393

Query: 823  ELQTTIS---SLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRD---NDQAIKVLQDELE 876
            E +  ++      EE+ +   A    L+  +Q+ ++E + L+ D    + A   L  +  
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453

Query: 877  NRSNQVRCAEKKLQ--HKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV 934
            N    +   ++K +  H ELE+ ++          K+K     SL     D + +LK + 
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL-----DQLETLKREN 1508

Query: 935  NFLQKRASILQEEL 948
              LQ+  S L E++
Sbjct: 1509 KNLQQEISDLTEQI 1522



 Score =  109 bits (272), Expect = 1e-23
 Identities = 144/735 (19%), Positives = 319/735 (43%), Gaps = 90/735 (12%)

Query: 181  QNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKS 240
            + +  ++ E+ SK+       +D+ A+     L  E+  + RQ     +L++ + S  K 
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRG--RLQTESGEFSRQLDEKEALVS-QLSRGKQ 1312

Query: 241  SSFHDDHFLSRIREKELDMKTKM---MEAKFHE-----EKLKLQQKHDADVQKILERKNN 292
            +       L R  E+E+  K  +   +++  H+     E+ + +Q+  A++Q+ L + N 
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372

Query: 293  EIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLN 352
            E+ + +T Y +   +  E + + +KK                  +A+  +  E+  E++N
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKK------------------LAQRLQAAEEHVEAVN 1414

Query: 353  NDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKE 412
                       A +E+ K  LQ +    +++L+ D   R N   +    + ++ + ++ E
Sbjct: 1415 --------AKCASLEKTKQRLQNE----VEDLMLDVE-RTNAACAALDKKQRNFDKILAE 1461

Query: 413  LEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVND 472
             + + ++   E E S  + + L  E  +++  Y+ +  +L+ +K     L +E   L   
Sbjct: 1462 WKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ 1521

Query: 473  YEQNMKLLQ--TKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE--SELQRK 528
              +  K +    K    +   K E   +  +A + +E  E  + +++ +L +  SE+ RK
Sbjct: 1522 IAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581

Query: 529  QQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRV 588
               +D+E   Q++++H++ I E     L +E+ + + D  +   K E  L E E QL   
Sbjct: 1582 IAEKDEEID-QLKRNHIR-IVESMQSTLDAEI-RSRNDAIRLKKKMEGDLNEMEIQLNHA 1638

Query: 589  TEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQME---KVEADLTRSKSLREKQSKE 645
                    + A  AL  ++     N++ +  + +  ++   + + DL    ++ E+++  
Sbjct: 1639 N-------RMAAEALRNYR-----NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686

Query: 646  FLWQLEDIRQRYEQ-----QIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQ 700
               ++E++R   EQ     +I E +L    E+  LL   N    +  +  E +I  ++ +
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGE 1746

Query: 701  LRAANMEHENQIQEFKK--RDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEE 758
            +     E  N  ++ KK   DA ++A+   +       L  +    +Q + +L L  +E 
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806

Query: 759  KQRATREHEIVVNKLKAESEKM--KIELKKTHAAETEMTLEKANSKLKQI---EKEYTQK 813
            +Q A +  +  + KL+A   ++  ++E ++   AE    L K   ++K++    +E  + 
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866

Query: 814  LAKSSQIIAELQTTISSLK------EENSQQQLAAERRLQDVRQKFEDE--------KKQ 859
            + +   ++ +LQ  + S K      EE S   LA  R+LQ   ++ E+          K 
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926

Query: 860  LIRDNDQAIKVLQDE 874
             ++  +   KV+ +E
Sbjct: 1927 RVKSREVHTKVISEE 1941



 Score =  106 bits (264), Expect = 1e-22
 Identities = 161/841 (19%), Positives = 360/841 (42%), Gaps = 96/841 (11%)

Query: 104  DEPNPARAKGSSPEGLPAWVLGELETSEHKLNESWKLSSG--EDNTLVQSPTDVYSR--E 159
            +E    RA  +  E   + +  ELE    +L E+   +S   E N   ++      R  E
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185

Query: 160  QYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPR 219
            + T +    + +L   H +    +  +I  +   K  +  + S+++  ++     +E   
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE--- 1242

Query: 220  YLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKH 279
                     ++   K +L K     +D  LS ++ KE + +  + +      +L   Q  
Sbjct: 1243 ---------TVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRL---QTE 1289

Query: 280  DADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKV----------QTLIRDCQVI 329
              +  + L+ K   + +L    ++   + EE  R+LE+++          Q+   DC ++
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349

Query: 330  RETKEDQIAELKKICEQSTESLNND---WEKKLHNAVAEMEQEKFDLQKQHTENIQ---E 383
            RE  E++  E K   +++    N +   W  K      +  +E  + +K+  + +Q   E
Sbjct: 1350 REQYEEE-QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408

Query: 384  LLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELER 443
             +E  N +   +E       Q   + +++L   V++        + +++   +  AE ++
Sbjct: 1409 HVEAVNAKCASLEKT----KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ 1464

Query: 444  CYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSA--SK 501
              + T +EL+  +    +L  E   + N YE+++  L+T    + NL ++   L+   ++
Sbjct: 1465 KCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1524

Query: 502  ASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELD 561
                I ELE+    +K+Q+++ + + +  L + E   + E+  +  I        Q EL+
Sbjct: 1525 GGKRIHELEK----IKKQVEQEKCELQAALEEAEASLEHEEGKILRI--------QLELN 1572

Query: 562  KGKEDTQKKIHKFEEALKEKEEQLTRVTEVQR--LQAQ---QADAALEEFKRQVELNSEK 616
            + K +  +KI + +E + + +    R+ E  +  L A+   + DA   + K + +LN  +
Sbjct: 1573 QVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632

Query: 617  VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLL 676
            +      +M    A+  R+    +   K+    L+D  +   Q+ ++ +L   + + +LL
Sbjct: 1633 IQLNHANRMA---AEALRNYRNTQGILKDTQIHLDDALR--SQEDLKEQLAMVERRANLL 1687

Query: 677  QQHNAEKDSLVRDHEREIENLEKQLRAANME------HENQIQEFKKRDAQVIADMEAQV 730
            Q    E  + +   ER  +  E++L  A+            +   KK+    I+ M+ ++
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747

Query: 731  HKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAA 790
              + +E  N   + K+ + +  ++ EE K+              A  E+MK  +++T   
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEELKKE---------QDTSAHLERMKKNMEQT-VK 1797

Query: 791  ETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAA---ERRLQ 847
            + ++ L++A     +  K+  QKL      + EL+  + S ++ N++        ERR++
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKLEAR---VRELEGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 848  DVRQKFEDEKKQLIRDND---------QAIKVLQDELENRSNQVRCAEKKLQHKELESQE 898
            ++  + E+++K ++R  D         ++ K   +E E +SN      +KLQH+  E++E
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914

Query: 899  Q 899
            +
Sbjct: 1915 R 1915



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 102/481 (21%), Positives = 218/481 (45%), Gaps = 77/481 (16%)

Query: 515  QLKQQLQESELQRKQQLRDQEN---KFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKI 571
            ++K  L+ +E +++     +E    K ++ KS  K    K+  +    L K K D Q ++
Sbjct: 841  KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKR---KELEEKMVTLLKEKNDLQLQV 897

Query: 572  HKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSE-KVYAEMKEQMEKVEA 630
                E L + EE+  ++                  K +++L ++ K   E  E  E++ A
Sbjct: 898  QAEAEGLADAEERCDQL-----------------IKTKIQLEAKIKEVTERAEDEEEINA 940

Query: 631  DLTRSKSLREKQSKEFLWQLEDI-----RQRYEQQIVELKLEHEQEKTHLLQQHNA---- 681
            +LT  K   E +  E    ++D+     +   E+   E K+++  E+   L +  A    
Sbjct: 941  ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 1000

Query: 682  EKDSLVRDHEREIENLEKQ------LRAANMEHENQIQEFK---KRDAQVIADMEAQVHK 732
            EK +L   H++ +++L+ +      L  A ++ E Q+ + +   +++ ++  D+E    K
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1060

Query: 733  L-------REELINVNSQRKQQLVELGLLRE----------EEKQRATREHEIVVNKLKA 775
            L       +E ++++ ++ KQQL E    +E          E++Q    + +  + +L+A
Sbjct: 1061 LEGDLKLAQESIMDIENE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119

Query: 776  ESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEEN 835
              E+++ E++   A+  +   EK  S L +  +E +++L ++       Q  ++  +E  
Sbjct: 1120 RIEELEEEIEAERASRAK--AEKQRSDLSRELEEISERLEEAGG-ATSAQIEMNKKREAE 1176

Query: 836  SQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELE 895
             Q+     R L++   + E     L + +  ++  L ++++N    ++  ++KL+ ++ E
Sbjct: 1177 FQKM---RRDLEEATLQHEATAATLRKKHADSVAELGEQIDN----LQRVKQKLEKEKSE 1229

Query: 896  SQEQITYIRQEYET--KLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQG 953
             + +I  +    ET  K KG +    R  LED +S LKS+    Q+    L  +LT  +G
Sbjct: 1230 MKMEIDDLASNVETVSKAKGNLEKMCR-TLEDQLSELKSKEEEQQR----LINDLTAQRG 1284

Query: 954  R 954
            R
Sbjct: 1285 R 1285


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score =  126 bits (316), Expect = 1e-28
 Identities = 159/790 (20%), Positives = 349/790 (44%), Gaps = 104/790 (13%)

Query: 231 MTPKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERK 290
           +T K +  +      D    R++E E +M+T+    +  +++L L       +Q+ L+++
Sbjct: 203 LTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMS---LQLQEALKKQ 259

Query: 291 NNEIEELKTLYRSKQHETEETIRKLEKKVQT---LIRDCQVIRETKEDQIAELKKICEQS 347
             + +E +   ++K  +TE    +LE++++    L+   +  RET   Q+ EL+    Q 
Sbjct: 260 EAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRT---QL 316

Query: 348 TESLNNDWEKKLHNAVAEMEQEKFDLQKQHTEN-------------IQELLEDTNVRLN- 393
           T++  +   K L + V+++ +++ + Q +  E+             +++ + D  V+LN 
Sbjct: 317 TKAEGD--RKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNF 374

Query: 394 -KMESEYMAQTQSTNHMIKE---LEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 449
             M SE     +      KE   L ++V+ LT E EN   Q+ +++    E++  +  TC
Sbjct: 375 SAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFD-TC 433

Query: 450 -----------------------------SELQEVKARRNTLHKEKDHLVNDYEQNMKLL 480
                                        SELQ+ +A +    K ++ L    +++++  
Sbjct: 434 EAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQW 493

Query: 481 QTKYDA-DINLLKQEHALS--ASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENK 537
           + K+   +  L KQ   +     K + +++E ++   QL   LQ+ E  RK+ L D   K
Sbjct: 494 KLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKE-LNDVLTK 552

Query: 538 FQMEKSHLKHIYEKKAHDL---QSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRL 594
             +++  L H  E+K  D+   Q++L+   +++   IH+ E  LK K+ ++    +V++ 
Sbjct: 553 RALQEEEL-HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELK-KQSKIQSQMKVEKA 610

Query: 595 QAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR 654
             ++  A L++ + Q +    ++   +K+ +  + ADL    +  E+  K  L  L D+ 
Sbjct: 611 HLEEEIAELKKSQAQDKAKLLEMQESIKD-LSAIRADLANKLAEEERAKKAVLKDLSDLT 669

Query: 655 QRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQE 714
            + + +        ++E   ++ Q   E+D     H+RE+++L   L++   +HE  IQE
Sbjct: 670 AQAKSR--------DEETATIITQLKLERDV----HQRELKDLTSSLQSVKTKHEQNIQE 717

Query: 715 FKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
             K   +  ++ E  +  L+ E +   +  K   +  G L + + Q      E+  N+ +
Sbjct: 718 LMKHFKKEKSEAENHIRTLKAESLEEKNMAK---IHRGQLEKLKSQCDRLTEELTQNENE 774

Query: 775 AESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEE 834
            +  K+K +  K    E E  +      L+++E+   Q   +   +  E ++ +  + +E
Sbjct: 775 NKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKE 834

Query: 835 ----------NSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRC 884
                     +S ++L       D+      +  + + ++   ++ L +EL+ R N+   
Sbjct: 835 IDAACKTFSKDSVEKLKVFSSGPDIHY----DPHRWLAESKTKLQWLCEELKERENR--- 887

Query: 885 AEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASIL 944
            EK L+H+ +  ++Q+  + +  E++L+ L     RQ  E  +  +  +   L +     
Sbjct: 888 -EKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQ--EQLLDEIHREKRDLLEETQRK 944

Query: 945 QEELTTYQGR 954
            EE+ + Q R
Sbjct: 945 DEEMGSLQDR 954


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  125 bits (314), Expect = 2e-28
 Identities = 161/687 (23%), Positives = 309/687 (44%), Gaps = 99/687 (14%)

Query: 258  DMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRK--- 314
            +++T +   + +  K+   +K +  + K +E   NEI + K   ++ Q+ +++ +++   
Sbjct: 478  ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537

Query: 315  LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQ 374
            LEK ++TL       RE  E QI    KI EQ  E LN         +    E    D++
Sbjct: 538  LEKTIETL-------RENSERQI----KILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586

Query: 375  KQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKL 434
            K++ + + E +++T+ +L+K+E E     +   H  KE   R ++L  E  +   + + L
Sbjct: 587  KEN-KILHESIKETSSKLSKIEFEKRQIKKELEHY-KEKGERAEELENELHHLEKENELL 644

Query: 435  IQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQE 494
             ++   L+    ITC +++ ++   + L +E          N KL +T  D+  NL  Q 
Sbjct: 645  QKKITNLK----ITCEKIEALEQENSELERE----------NRKLKKT-LDSFKNLTFQL 689

Query: 495  HALSASKASSMIEE----LEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYE 550
             +L   K +S ++E    L +NV  LK         +  QL+ +  + + EK  LK   E
Sbjct: 690  ESLE--KENSQLDEENLELRRNVESLK-----CASMKMAQLQLENKELESEKEQLKKGLE 742

Query: 551  --KKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKR 608
              K +      L+   +    +  + ++ L+   ++      +Q+L+++  D  +E    
Sbjct: 743  LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK------IQQLESELQDLEMENQTL 796

Query: 609  QVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEH 668
            Q  L   K+ ++  EQ+EK    L +  S  EK  K+   + E+ R R + +I +  LE 
Sbjct: 797  QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL--EKENKRLRQQAEIKDTTLEE 854

Query: 669  EQEKTHLLQQHNAE--------KDSLVRDHEREIENLEKQLRAA------NMEHENQIQE 714
               K   L++ N          K+S VR  E E EN E   RA           E+ + E
Sbjct: 855  NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914

Query: 715  FKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
             K +  Q+  D+E   H+L  E I +N +R        LL +E+    +R ++++ +KL+
Sbjct: 915  -KLKTQQMNNDLEKLTHEL--EKIGLNKER--------LLHDEQSTDDSR-YKLLESKLE 962

Query: 775  AESEKMKIELKKTHAAETEMTLEKANS-------KLKQIEKEY--------TQKLAKSSQ 819
            +  +K  +E+K+   A  E  LE++ +       +LK ++K Y         +++ +SS 
Sbjct: 963  STLKK-SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021

Query: 820  IIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRS 879
             I+          +E +++ L  + RL +V     +     ++   QA+K    +LE ++
Sbjct: 1022 PISGEDNKWERESQETTRELLKVKDRLIEV-----ERNNATLQAEKQALKTQLKQLETQN 1076

Query: 880  NQVRCAEKKLQHKELESQEQITYIRQE 906
            N ++     LQ + +  QEQ T ++ +
Sbjct: 1077 NNLQAQILALQRQTVSLQEQNTTLQTQ 1103



 Score =  102 bits (254), Expect = 2e-21
 Identities = 168/740 (22%), Positives = 318/740 (42%), Gaps = 133/740 (17%)

Query: 317 KKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHN----------AVAEM 366
           KK+  L+  C V  + KE+ I  ++ +   +  ++    ++  HN           V +M
Sbjct: 122 KKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDM 181

Query: 367 EQEK---------------FDLQKQHTENIQELLED----------TNVRLNKMESEYMA 401
            QE                 D + +H+E I EL E+          ++   +   S  M 
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241

Query: 402 QTQSTNHMIKEL---EARVQQLTGEAENSNLQ----RQKLIQEKAELERCYQITCSELQE 454
           +T+S  H+  EL   +A++++L  E E    Q    +Q+L Q + EL+R  Q   + L +
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 455 VKARRN----------------------TLHKEKDHLVNDY--------EQNMKLLQTKY 484
            ++ R                       + +KE+ H +  Y        E N  LL+TK 
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK- 360

Query: 485 DADINLLKQEHALSASKA-SSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKS 543
                    E  L  ++A S  + ELE+   QLK +L + E++R    +  E    ME++
Sbjct: 361 ------TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE--LMEEN 412

Query: 544 HLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAAL 603
               + +K++ D    L    E   +     E   K    ++  +T  + L+ +  + +L
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 604 ----EEFKR---QVELNSEKVYAEMKE-QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQ 655
               EE +     VE N+ K+    KE Q    + ++  ++ ++EKQS +    L     
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532

Query: 656 RYEQQI---VELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQI 712
           + + Q+   +E   E+ + +  +L+Q N   +  V    R+   +  + R  ++E EN+I
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTV-SSLRQRSQISAEARVKDIEKENKI 591

Query: 713 -QEFKKRDAQVIADMEAQVHKLREEL--INVNSQRKQQLV-ELGLLREEEK--QRATREH 766
             E  K  +  ++ +E +  ++++EL       +R ++L  EL  L +E +  Q+     
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651

Query: 767 EIVVNKLKA------ESEKMKIELKKTHAAETEMT-----LEKANSKLKQIEKEY---TQ 812
           +I   K++A      E E+   +LKKT  +   +T     LEK NS+L +   E     +
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711

Query: 813 KLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKV-- 870
            L  +S  +A+LQ     L+ E  Q     ++ L+ ++  F  +K + +  + Q + +  
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQ----LKKGLELLKASF--KKTERLEVSYQGLDIEN 765

Query: 871 --LQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLR-QELEDTI 927
             LQ  LEN + +++  E +LQ  E+E+        Q  +  L+ L  +S R ++LE   
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMEN--------QTLQKNLEELKISSKRLEQLEKEN 817

Query: 928 SSLKSQVNFLQKRASILQEE 947
            SL+ + + L+K    L++E
Sbjct: 818 KSLEQETSQLEKDKKQLEKE 837



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 157/782 (20%), Positives = 338/782 (43%), Gaps = 115/782 (14%)

Query: 255  KELDMKTKMMEAKFHEEKLKLQQ---------KHDADVQKILE--RKNNEIEELKTLYRS 303
            + L  K +++E +  +EK  LQ          K  A ++K +E  R+N+E  ++K L + 
Sbjct: 501  QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE-RQIKILEQE 559

Query: 304  KQH--ETEETIRK-----LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWE 356
             +H  +T  ++R+      E +V+ + ++ +++ E+ ++  ++L KI E     +  + E
Sbjct: 560  NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI-EFEKRQIKKELE 618

Query: 357  --KKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMES--EYMAQTQSTNHMIKE 412
              K+      E+E E   L+K++ E +Q+ + +  +   K+E+  +  ++ +  N  +K+
Sbjct: 619  HYKEKGERAEELENELHHLEKEN-ELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 413  LEARVQQLTGEAENSNLQRQKLIQEKAELER------CYQITCSELQ----EVKARRNTL 462
                 + LT + E+   +  +L +E  EL R      C  +  ++LQ    E+++ +  L
Sbjct: 678  TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737

Query: 463  HKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSAS-----KASSMIEELEQNVCQLK 517
             K  + L   +++  +L  +    DI   + +  L  S     +  S +++LE     L+
Sbjct: 738  KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797

Query: 518  QQLQESELQRKQ-QLRDQENKF------QMEKSHLKHIYEKKAHDLQSEL-DKGKEDTQK 569
            + L+E ++  K+ +  ++ENK       Q+EK   +   E K    Q+E+ D   E+   
Sbjct: 798  KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857

Query: 570  KIHKFEEALK--EKE-----EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMK 622
            KI   E+  K   KE     E   R+ E+++   +    A  + K  V L  + V  ++K
Sbjct: 858  KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917

Query: 623  EQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEH--------EQEKTH 674
             Q    + +    +  +   +KE L   E        +++E KLE         ++EK  
Sbjct: 918  TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIA 977

Query: 675  LLQQHNAEKDSLVRDHEREIENLEKQLRAANM--EHENQIQEFK---------KRDAQVI 723
             L+    E  +  +   +E++ ++K   A     + E  +Q            +R++Q  
Sbjct: 978  ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ-- 1035

Query: 724  ADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIE 783
             +   ++ K+++ LI V         E   L+ + KQ  T+ + +    L  + + + ++
Sbjct: 1036 -ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1094

Query: 784  LKKTHAAETEMTLEKANSKLK----QIEKEYTQKLAKSSQII-----------------A 822
             + T       TL+  N+KL+     +  + T  + +++Q++                  
Sbjct: 1095 EQNT-------TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147

Query: 823  ELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQV 882
            +L++   SL +++ + +L  ER+  +        K   ++   + ++V   +LE+R NQ+
Sbjct: 1148 DLKSLYDSLIKDHEKLELLHERQASEYESLI--SKHGTLKSAHKNLEVEHRDLEDRYNQL 1205

Query: 883  RCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQ------ELEDTISSLKSQVNF 936
               ++K Q ++LE   ++   +   E K    + A  ++       L  T S L  +   
Sbjct: 1206 --LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1263

Query: 937  LQ 938
            LQ
Sbjct: 1264 LQ 1265



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 154/698 (22%), Positives = 302/698 (43%), Gaps = 109/698 (15%)

Query: 336 QIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQ------------- 382
           +I  L++  E+ TE        +L +   E+EQ + +L++   EN+              
Sbjct: 259 KIRRLRQELEEKTE--------QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310

Query: 383 --ELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAE 440
             + L +  VR++K+ESE +++ +   H I+  +ARV++L  E     L+ + +++++ E
Sbjct: 311 ELDALREKAVRVDKLESE-VSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLE 368

Query: 441 LERCYQITCSELQ----EVKARRNTLHKEKD----HLVNDYEQNMKL-LQTKYDADINL- 490
             R       EL+    ++KA+ + +  E+D     +    E+NM L +  K   D +L 
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLH 428

Query: 491 -------LKQEHALSASKASSMIEELEQNVCQ--LKQQLQESELQRK-QQLR-------- 532
                  + +   LS +   S+  E+ +      LK +++   L +  ++LR        
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488

Query: 533 DQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQ 592
           +     +MEK + +    KK   L++E+ + K+  Q   +  ++ +KEK  QL +  E  
Sbjct: 489 NASKILKMEKENQR--LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK-AQLEKTIETL 545

Query: 593 RLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLED 652
           R  +++    LE+    +      +    +   E    D+ +   +  +  KE   +L  
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605

Query: 653 IRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE-------------REIENLEK 699
           I   +E++ ++ +LEH +EK    ++   E   L +++E              +IE LE+
Sbjct: 606 I--EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663

Query: 700 ---QLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLRE 756
              +L   N + +  +  FK    Q +  +E +  +L EE  N+  +R  + ++   ++ 
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQ-LESLEKENSQLDEE--NLELRRNVESLKCASMKM 720

Query: 757 EEKQRATREHEIVVNKLKAESEKMKIELKKTHAAET------------EMTLEKANSKLK 804
            + Q   +E E    +LK   E +K   KKT   E             + TLE +N K++
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780

Query: 805 QIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ-QQLAAERR-LQDVRQKFEDEKKQLIR 862
           Q+E E  Q L   +Q    LQ  +  LK  + + +QL  E + L+    + E +KKQL +
Sbjct: 781 QLESE-LQDLEMENQ---TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836

Query: 863 DND---QAIKVLQDELENRSNQVRCAEK--KLQHKELESQEQITYIRQEYETKLKGLMP- 916
           +N    Q  ++    LE  + ++   EK  K   KE+   ++     +E E + K L+  
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896

Query: 917 --------ASLRQELEDTISSLKSQVNFLQKRASILQE 946
                    +LR++L       +   N L+K    L++
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 110/521 (21%), Positives = 227/521 (43%), Gaps = 68/521 (13%)

Query: 252  IREKELDMKTKM-MEAKFHEEKLKLQQKHDADVQKILERKNNEIEEL----KTLYRSKQH 306
            ++   +D+KT + +      EKLK QQ ++      LE+  +E+E++    + L   +Q 
Sbjct: 894  VKRATIDIKTLVTLREDLVSEKLKTQQMNND-----LEKLTHELEKIGLNKERLLHDEQS 948

Query: 307  ETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQST---ESLNNDWE--KKLHN 361
              +   + LE K+++ ++      E KE++IA L+   E+ST   + L  + +  KK + 
Sbjct: 949  TDDSRYKLLESKLESTLKKSL---EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 1005

Query: 362  AVAEMEQEKFDLQ-------------KQHTENIQELLE--DTNVRLNKMESEYMAQTQST 406
            A+ + + E+  +Q             ++  E  +ELL+  D  + + +  +   A+ Q+ 
Sbjct: 1006 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1065

Query: 407  NHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKAR--RNTLHK 464
               +K+LE          +N+NLQ Q L  ++  +    Q T  + Q  K +   +TL+ 
Sbjct: 1066 KTQLKQLET---------QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1116

Query: 465  EKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESE 524
            +   L+N   Q              LL Q+ +L  ++  S+I+E E         +++ E
Sbjct: 1117 QSTSLMNQNAQ--------------LLIQQSSLE-NENESVIKEREDLKSLYDSLIKDHE 1161

Query: 525  LQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQ 584
               K +L  +    + E    KH   K AH       +  ED   ++ K +  L++ E+ 
Sbjct: 1162 ---KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM 1218

Query: 585  LTRVTEVQRLQAQQADAALEEFKRQVELNS--EKVYAEMKEQMEKVEADLTRSKSLREKQ 642
            L    E   L+ +  +    E+K+    N      Y+++ ++ E ++ D    KSL    
Sbjct: 1219 LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNS 1278

Query: 643  SKE---FLWQLEDIRQRYEQ-QIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLE 698
              E      +   ++++Y+Q  I   KL ++ E    L+ +  E++  + D  + +    
Sbjct: 1279 KLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQN 1338

Query: 699  KQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELIN 739
            + L   NME ++     +++    + ++  Q  KL E++++
Sbjct: 1339 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 152/719 (21%), Positives = 298/719 (41%), Gaps = 134/719 (18%)

Query: 345 EQSTESLNNDWEKKLHNAVAEMEQEKFDLQ-----------------------KQHTENI 381
           ++  + +NND   ++HN    + Q KF  Q                       +Q TE +
Sbjct: 62  QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEV 121

Query: 382 QE---LLEDTNVRLNKMESEYMAQTQSTNHMIK-ELEARVQQLTGEAEN-SNLQRQKLI- 435
           ++   LL    V+  K E E++ + Q  +   K  + A +Q++T   EN  +LQ  ++  
Sbjct: 122 KKLLLLLLGCAVQCQKKE-EFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180

Query: 436 QEKAELERCYQITCSELQEVKARRN-------TLHKEKDHL------------------- 469
             + ++E   +     L+ +   R+        L +E+D L                   
Sbjct: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240

Query: 470 -VNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE-----S 523
              +  Q++ +      A I  L+QE      +     +ELEQ   +LK+  QE     S
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300

Query: 524 ELQRKQQLRDQENKFQMEKSHLKHI------YEKKAHDLQ---SELDKGKEDTQKKIH-- 572
           + +  +  RD+ +  + +   +  +      Y+++ HD++   + +++ KED Q  +   
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360

Query: 573 -KFEEALKEKEEQLTRVTEVQR----LQAQQADAALE---EFKRQVELNSEKVYAEMKEQ 624
              E+ L+    +  ++ E+++    L+A+  D  +E   + K+  EL  E +  EM ++
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420

Query: 625 MEKVEA--------DLTRSKSLREKQSKEF-----------LWQLEDIRQRYEQQIVELK 665
               E+         ++R+  L E   K             L +LE   Q   + + EL+
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480

Query: 666 -------------LEHEQEKTHLLQQHNAEKDSLVRDHE--REIENLEKQLRAANMEHEN 710
                        L+ E+E   L ++    ++ +V++ +  +  +NL K L     + E 
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540

Query: 711 QIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATRE--HEI 768
            I+  ++   + I  +E +   L + + ++  QR Q   E  +   E++ +   E   E 
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKENKILHESIKET 599

Query: 769 VVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEK--EYTQKLAKSSQIIAELQT 826
                K E EK +I+ +  H  E     E+  ++L  +EK  E  QK   + +I  E   
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCE--- 656

Query: 827 TISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSN--QVRC 884
            I +L++ENS+ +    R+L+     F++   QL     +  ++ ++ LE R N   ++C
Sbjct: 657 KIEALEQENSELE-RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715

Query: 885 AEKKLQHKELESQEQITYIRQEYETKLKG--LMPASLR--QELEDTISSLKSQVNFLQK 939
           A  K+   +LE++E    +  E E   KG  L+ AS +  + LE +   L  +   LQK
Sbjct: 716 ASMKMAQLQLENKE----LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  125 bits (314), Expect = 2e-28
 Identities = 174/794 (21%), Positives = 354/794 (44%), Gaps = 130/794 (16%)

Query: 249  LSRIREKELDMKTKMMEA--------KFHEEKLKLQQKHDADVQKILERKNNEIEELKTL 300
            ++++  K L+ + ++ EA        +   EKL  +++  AD+Q  L R   +++E  T 
Sbjct: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 301  YRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLH 360
                QH+ ++T ++ +++        Q ++++   ++ E +   EQ    +  D ++K+ 
Sbjct: 476  STELQHQLDKTKQQHQEQ--------QALQQSTTAKLREAQNDLEQVLRQIG-DKDQKIQ 526

Query: 361  N--AVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQ 418
            N  A+ +  +E   L ++  E++        ++  + E+  + Q Q  NH ++E   +V 
Sbjct: 527  NLEALLQKSKENISLLEKEREDLY-----AKIQAGEGETAVLNQLQEKNHTLQE---QVT 578

Query: 419  QLTGEAEN---SNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ 475
            QLT + +N   S+ Q Q+ + ++ + ++ +       Q+      T   E +  +N+ ++
Sbjct: 579  QLTEKLKNQSESHKQAQENLHDQVQEQKAH---LRAAQDRVLSLETSVNELNSQLNESKE 635

Query: 476  NMKLLQTKYDADINLLKQEHALSASKASSMIEELE--QNVCQLKQQ-LQESELQRKQ--- 529
             +  L  +  A   LL    A   ++ + +   L+  QN  Q KQQ L +   Q  Q   
Sbjct: 636  KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695

Query: 530  QLRDQENKFQMEKSHLKHIYEK------KAHDLQSELDKGKEDTQKKIHKFEEALKEKEE 583
            +L+D++      +SHLK   EK      K  +L+ ++ K + D+ +     E+AL++ ++
Sbjct: 696  KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755

Query: 584  QLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLR---- 639
            Q    T+++ L+A +    LE  ++++  ++     +  E +E ++  LT+ +  +    
Sbjct: 756  QRQLNTDLE-LRATELSKQLE-MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK 813

Query: 640  ---EKQSKEFLWQLEDIRQRYEQQIVEL---KLEHEQEKTHL------------------ 675
               E  S+E   Q E++  R +  + EL   K+E E   T L                  
Sbjct: 814  QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873

Query: 676  --LQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKL 733
               ++ N +  + + D E+  + L+ QL+   ++ EN ++E K+    +  + EA  H+L
Sbjct: 874  SEFEKENQKGKAAILDLEKTCKELKHQLQ---VQMENTLKEQKELKKSLEKEKEAS-HQL 929

Query: 734  REELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETE 793
            + EL   NS ++Q +     L++ EK+    +  I  N+LK  SE+ K +++        
Sbjct: 930  KLEL---NSMQEQLIQAQNTLKQNEKEEQQLQGNI--NELKQSSEQKKKQIEALQGELKI 984

Query: 794  MTLEKA--NSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQ----------LA 841
              L+K    +KL+Q   +  Q+LA   + I+ LQ      +E   Q Q          LA
Sbjct: 985  AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044

Query: 842  AERRLQDVRQKFEDEKKQLIRDND---------QAIKVLQDELENRSN------QVRC-- 884
              + L+ V +K    ++ LI + +         Q +K  +  LE  S       Q RC  
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104

Query: 885  -----AEKKLQHKELESQE----QITYIRQEYETKLKGLMPASLRQELED-TISSLKSQV 934
                  EK L+ KEL +++    +I  I+   E ++       L +EL+   + S+K   
Sbjct: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI-----TKLNEELKSHKLESIKEIT 1159

Query: 935  NFLQKRASILQEEL 948
            N    +  ++Q++L
Sbjct: 1160 NLKDAKQLLIQQKL 1173



 Score =  118 bits (296), Expect = 2e-26
 Identities = 179/821 (21%), Positives = 360/821 (43%), Gaps = 131/821 (15%)

Query: 239 KSSSFHDDHFLSRIREKELDMKTKMMEAKF-HEEKLKLQQKHDADVQKILERKNNE---I 294
           ++ +F+         +K   + T++ + K  ++E+  L++  +  V ++ E  N E   I
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207

Query: 295 EELKT-LYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIA-ELKKICEQSTES-- 350
           ++LKT L +    E    ++K   +VQTL+ +  + RE + +++  E KK+  Q   S  
Sbjct: 208 QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267

Query: 351 ----LNNDWEK-------------KLHNAVAEM--------------EQEKFDLQKQHTE 379
               L ++  K             KL ++V E+              EQ+   L+++H E
Sbjct: 268 TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE 327

Query: 380 ------NIQELLEDTNVRLNKMESEYMAQ-----------------TQSTNHMIKELEAR 416
                 NIQ  L   ++   +++S   A                  TQ     + E+E +
Sbjct: 328 ESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETK 387

Query: 417 VQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLH---KEKDHL---- 469
            Q L  E +    QR++  Q   +L+       S+L E + +    H   KE+  L    
Sbjct: 388 YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK 447

Query: 470 VNDYEQNMKLLQTKYDADINLLKQ--------EHALSASKASSMIEE-LEQNVCQLKQQL 520
           + D EQ +  LQ K       LK+        +H L  +K     ++ L+Q+     ++ 
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507

Query: 521 QESELQRKQQLRDQENKFQMEKSHLK------HIYEKKAHDLQSELDKGKEDTQKKIHKF 574
           Q    Q  +Q+ D++ K Q  ++ L+       + EK+  DL +++  G+ +T   +++ 
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET-AVLNQL 566

Query: 575 EEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
           +E     +EQ+T++TE  + Q++    A E    QV+     + A  ++++  +E  +  
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRA-AQDRVLSLETSVNE 625

Query: 635 SKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL---LQQHNAEKDSLVRDHE 691
             S +  +SKE + QL DI+ + +    EL L  E  KT     LQ H     + ++D +
Sbjct: 626 LNS-QLNESKEKVSQL-DIQIKAK---TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680

Query: 692 REIENLEKQLRAA------NMEH----ENQIQEFKKRD---AQVIADMEAQVHKLREELI 738
           +E+  +  QL           EH    E+ ++E+K++     Q   ++E Q+ KL  + +
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740

Query: 739 NVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEK 798
            V + ++Q L +L    ++++Q  T        +L+A     ++E++K   + T + L+K
Sbjct: 741 EVKASKEQALQDL----QQQRQLNTD------LELRATELSKQLEMEKEIVSSTRLDLQK 790

Query: 799 ANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDV---RQKFED 855
            +  L+ I+    QKL K  +    L+    +L +E   Q      R+Q      QK + 
Sbjct: 791 KSEALESIK----QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846

Query: 856 EKKQLIRD----NDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKL 911
           EK+ L+ +     D+  KV  D L+N  ++     +K +   L+ ++    ++ + + ++
Sbjct: 847 EKEALMTELSTVKDKLSKV-SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905

Query: 912 KGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
           +  +    ++EL+ ++   K   + L+   + +QE+L   Q
Sbjct: 906 ENTLKE--QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944



 Score =  108 bits (270), Expect = 2e-23
 Identities = 146/637 (22%), Positives = 289/637 (45%), Gaps = 69/637 (10%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETI 312
            + +EL+ + K +EA   E K   +Q    D+Q+  +R+ N   EL+    SKQ E E+ I
Sbjct: 724  KTEELEGQIKKLEADSLEVKASKEQALQ-DLQQ--QRQLNTDLELRATELSKQLEMEKEI 780

Query: 313  RK-----LEKKVQTLIRDCQVIRETKEDQ--IAELKKICEQSTESLNNDWEKKLHNAVAE 365
                   L+KK + L    Q + + +E++  + +  +   Q T+  + +   ++   V E
Sbjct: 781  VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840

Query: 366  MEQEKFDLQKQHTE--NIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGE 423
            +++ K + +   TE   +++ L   +  L   +SE+  + Q     I +LE   ++L  +
Sbjct: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900

Query: 424  AENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTK 483
             +   +Q +  ++E+ EL++  +       ++K   N++ ++     N  +QN K  Q +
Sbjct: 901  LQ---VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ-Q 956

Query: 484  YDADINLLKQEHALSASKASSMIEELEQNVCQ---LKQQLQESELQRKQQLRDQENKFQM 540
               +IN LKQ       +  ++  EL+  V Q   L+ +LQ+   Q  Q+L  ++ K  +
Sbjct: 957  LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1016

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTE---VQRLQAQ 597
                L++ YEK     + +L       + ++    + LK  EE+L+   E     R Q  
Sbjct: 1017 ----LQNNYEKSQETFK-QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG 1071

Query: 598  QADAALEEFKRQ---VELNSEKVYAEMKEQMEKVEADLTRSKSLREKQ---SKEFLWQLE 651
              +  ++E K     +E +S K   +++E+ + ++ D+ + KSL+EK+    K  L ++E
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ-DIQKEKSLKEKELVNEKSKLAEIE 1130

Query: 652  DIRQRYEQQIVEL-------KLEHEQEKTHL-------LQQH---NAEKDSLVRDHEREI 694
            +I+ R E++I +L       KLE  +E T+L       +QQ      + DSL    E+E 
Sbjct: 1131 EIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190

Query: 695  ENLEKQLRAANMEHENQIQEFKKRDAQV---IADMEAQVHKLREELINVNSQRKQQLVEL 751
             N +        E E   +EF +++A++   I + E  + K  E    +  Q       L
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250

Query: 752  GLLREE-----------EKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKAN 800
            G +++E           EKQ      EI V +   ++ + +         + E  +EK  
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310

Query: 801  SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ 837
            +K+ ++++    KL  ++  + EL     SL+ +++Q
Sbjct: 1311 TKVLELQR----KLDNTTAAVQELGRENQSLQIKHTQ 1343



 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 152/715 (21%), Positives = 306/715 (42%), Gaps = 120/715 (16%)

Query: 333 KEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRL 392
           K D +  L++  +    SL    E+K ++   + E EK+   +Q       L+ D++  L
Sbjct: 81  KRDDVTLLRQEVQDLQASLK---EEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAEL 137

Query: 393 NKMESEYMAQTQSTNHMIKEL-----------------------------EARVQQLTGE 423
             +E + + + Q+ N  IK++                             EA  Q++T  
Sbjct: 138 QSLEQQ-LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196

Query: 424 AENSNLQRQKLIQEKAELER-----CYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMK 478
            E  N +   +   K EL +        +   EL +V+   + +  E++      +   K
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256

Query: 479 LLQTKY---DADINLLKQEHALSASKASSMIEELEQ------NVCQLKQQLQESELQRKQ 529
            LQ++Y   +A I+ L+ E A    + +  ++EL++       + Q  Q L E+ L+++Q
Sbjct: 257 KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316

Query: 530 ---QLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEK----- 581
              +L ++ N+  + K +++    +K  D Q +L      ++  +H+    L EK     
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQ-QLQSRLSASETSLHRIHVELSEKGEATQ 375

Query: 582 --EEQLTRV--------TEVQRLQAQQADAALEEFKRQVELNS-EKVYAEMKEQMEKVEA 630
             +E+L+ V         E ++LQ Q+ +      + Q E+N       E + Q+ +   
Sbjct: 376 KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435

Query: 631 DLTRSKSLREKQSKEFLWQLEDIR---QRYEQQIVE-----LKLEHEQEKTHLLQQHNAE 682
            L   + L  ++  +   Q+ D++    R E+Q+ E      +L+H+ +KT   QQH   
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK--QQH--- 490

Query: 683 KDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNS 742
                ++ +   ++   +LR A  + E  +++   +D Q I ++EA + K +E +  +  
Sbjct: 491 -----QEQQALQQSTTAKLREAQNDLEQVLRQIGDKD-QKIQNLEALLQKSKENISLLEK 544

Query: 743 QRKQQLV-------ELGLLREEEKQRATREHEI--VVNKLKAESEKMKIELKKTH--AAE 791
           +R+           E  +L + +++  T + ++  +  KLK +SE  K   +  H    E
Sbjct: 545 EREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE 604

Query: 792 TEMTLEKANSKLKQIE---KEYTQKLAKSSQIIAELQTTIS-------SLKEENSQQQLA 841
            +  L  A  ++  +E    E   +L +S + +++L   I        S +   + Q+  
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664

Query: 842 AERRLQDVRQKFEDEKKQLIR---DNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQE 898
            +  L   +   +D++++L +     DQ    LQD+ E+ S Q+    K+ + K L S E
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS-QLESHLKEYKEKYL-SLE 722

Query: 899 QITYIRQEYETKLKGLMPASL--RQELEDTISSLKSQVNF---LQKRASILQEEL 948
           Q T   +E E ++K L   SL  +   E  +  L+ Q      L+ RA+ L ++L
Sbjct: 723 QKT---EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 112/489 (22%), Positives = 222/489 (45%), Gaps = 52/489 (10%)

Query: 257  LDMKTKMMEAKFHEEKLKLQQ--KHDADVQKILERKNNEIEELKTLYRSKQHE---TEET 311
            LD++    E K H+ +++++   K   +++K LE++     +LK    S Q +    + T
Sbjct: 888  LDLEKTCKELK-HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946

Query: 312  IRKLEKKVQTL---IRDCQVIRETKEDQI----AELKKICEQSTESLNNDWEKKLHNAVA 364
            +++ EK+ Q L   I + +   E K+ QI     ELK    Q TE L N  +++L  A  
Sbjct: 947  LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE-LENKLQQQLTQAAQ 1005

Query: 365  EM--EQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTG 422
            E+  E+EK  + + + E  QE  +         ESE +A  Q    + ++L    + L  
Sbjct: 1006 ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065

Query: 423  EA-----ENSNLQRQK-----LIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVND 472
                   +N  +Q  K     L Q+ A+ E+  Q  C  LQ+++  ++   KE   LVN+
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE---LVNE 1122

Query: 473  YE-----QNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQR 527
                   + +K  Q K    +N   + H L + K  + +++ +Q + Q K +LQ      
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182

Query: 528  KQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTR 587
            K  +  ++   Q+ K  +K    K+  +L+ E  + +     +I + E  +K+ EE   +
Sbjct: 1183 KAAVEQEKRNQQILKDQVK----KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK 1238

Query: 588  VTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFL 647
            +T    +Q    +  L   K++ + +S++  +E+++Q + +  ++   ++  +    E  
Sbjct: 1239 LT----MQITALNENLGTVKKEWQ-SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293

Query: 648  WQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLE-KQLRAANM 706
              LE   +       E ++E  Q K   LQ+      + V++  RE ++L+ K  +A N 
Sbjct: 1294 ALLERCLKG------EGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347

Query: 707  E--HENQIQ 713
            +   +N++Q
Sbjct: 1348 KWAEDNEVQ 1356



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 89/341 (26%), Positives = 155/341 (45%), Gaps = 49/341 (14%)

Query: 658 EQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHEN--QIQE- 714
           E++    +L+ E EK   LQQ  A+ D LV D   E+++LE+QL  A  E+ N  Q+++ 
Sbjct: 101 EEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160

Query: 715 FKKRDAQV---IADM--------------EAQVHKLREEL---------INVNSQRKQQL 748
           F+++ AQ+   IAD+              E +V +L EEL         +     ++  +
Sbjct: 161 FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220

Query: 749 VELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHA--AETEMTLEKANSKLKQI 806
            ++ +L++E  Q  T    + + + + ESEK+K E KK  +  A +E T+ +  S+L + 
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLER-ERESEKLKDECKKLQSQYASSEATISQLRSELAKG 279

Query: 807 EKE---YTQKLAKSSQIIAEL----QT-TISSLKEENSQQQLAAERRLQDVRQKFEDEKK 858
            +E   Y Q+L K    + EL    QT T + LK+E    +L  +   + V +K     +
Sbjct: 280 PQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKK---NIQ 336

Query: 859 QLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMP-- 916
             +   D   + LQ  L      +     +L  K  E+ +++     E ETK + L    
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG-EATQKLKEELSEVETKYQHLKAEF 395

Query: 917 ---ASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGR 954
                 R+E E     L+S++N L  +    + +L    GR
Sbjct: 396 KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR 436


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  125 bits (314), Expect = 2e-28
 Identities = 154/670 (22%), Positives = 294/670 (43%), Gaps = 99/670 (14%)

Query: 314  KLEKKVQTLIRDCQVIRETKEDQIAE--LKKICEQSTESLNNDWEKKLHNAVAEMEQEKF 371
            +L  KV+ L+   QV R+ +E Q  E  L+K  E+         ++K  N + E+EQ+  
Sbjct: 836  RLFTKVKPLL---QVTRQEEEMQAKEDELQKTKER---------QQKAENELKELEQKHS 883

Query: 372  DLQKQHTENIQELLEDTNV--RLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
             L ++     ++L  +T +     +M     A+ Q    ++ E+EAR+++     +    
Sbjct: 884  QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 943

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKY---DA 486
            +R+K+ Q+  +LE        +L+E +A R  L  EK       E  +K L+ +    D 
Sbjct: 944  ERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDD 992

Query: 487  DINLLKQEHALSASKASSMI------EELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
              N L +E  L   + S +       EE  +N+ +LK +  ES +   +    +E K + 
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1051

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD 600
            E   LK   E  A D   ++     D Q +I + +  L +KEE+L           Q A 
Sbjct: 1052 ELEKLKRKLEGDASDFHEQI----ADLQAQIAELKMQLAKKEEEL-----------QAAL 1096

Query: 601  AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660
            A L++   Q   N+ K   E++  +  ++ DL   ++ R K  K    Q  D+ +  E +
Sbjct: 1097 ARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGE--ELE 1149

Query: 661  IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA 720
             ++ +LE   + T   Q+  A++       E+E+  L+K L      HE Q+QE +++ A
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKR-------EQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            Q + ++  Q+ + +    N++  ++    E   L  E +     + E+   K K E++  
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262

Query: 781  KIELKKTHAAETEMTLEKANSKLKQIEKEYTQ-------------KLAKS-SQIIAELQT 826
            +++ K    ++ E    + N K+ +++ E                KLAK  + + ++LQ 
Sbjct: 1263 ELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 827  TISSLKEENSQQQLAAE--RRLQDVRQKFED------EKKQLIRDNDQAIKVLQDELENR 878
            T   L+EE  Q+   +   R+L++ R   +D      E KQ +  +   + +   + + +
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 879  SNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGL-----MPASLRQELEDTISSLKSQ 933
                    + L+  +   Q++I  + Q+YE K             L+QEL+D +  L +Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 934  ---VNFLQKR 940
               V+ L+K+
Sbjct: 1440 RQLVSNLEKK 1449



 Score =  125 bits (313), Expect = 2e-28
 Identities = 169/765 (22%), Positives = 335/765 (43%), Gaps = 148/765 (19%)

Query: 252  IREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKI--------------------LERKN 291
            + +K LD +T+  EA+  E    ++QKH   V+++                    LE++N
Sbjct: 1178 VLKKALDEETRSHEAQVQE----MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233

Query: 292  NEIE-ELKTLYRSKQHETEETIRKLEKKVQTLIRDC---QVIRETKEDQIAELKKICEQS 347
             ++  EL+ L ++KQ E E   +KLE +VQ L   C   +  R    D++ +L+   E  
Sbjct: 1234 ADLAGELRVLGQAKQ-EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292

Query: 348  TESLNNDWEK--KLHNAVAEMEQEKFDLQKQHTEN----------IQELLEDTNVRLNKM 395
            T  LN    K  KL   VA +  +  D Q+   E           +++L E+ N   +++
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1352

Query: 396  ESEYMAQTQSTNHM------IKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 449
            + E  A+     H+      + + + ++Q      E     +++  +E   L + Y+   
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412

Query: 450  SELQEVKARRNTLHKEKDHLVNDYEQNMKLL------QTKYD---ADINLLKQEHALSAS 500
            +   +++  +N L +E D LV D +   +L+      Q K+D   A+   +  ++A    
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472

Query: 501  KASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSEL 560
            +A +   E E     L + L+E+ L+ K++L   E   +M K+ ++            +L
Sbjct: 1473 RAEAEAREKETKALSLARALEEA-LEAKEEL---ERTNKMLKAEME------------DL 1516

Query: 561  DKGKEDTQKKIHKFEEALKEKEEQLTRV-TEVQRLQAQQADAALEEFKRQVELNSEKVYA 619
               K+D  K +H+ E++ +  E Q+  + T+++ L+ +    A E+ K ++E+N + +  
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--ATEDAKLRLEVNMQALKG 1574

Query: 620  EMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR-QRYEQQIVELKLEHEQEKTHLLQQ 678
            + +  ++  +      +   ++Q  E+  +LED R QR      + KLE + +   L   
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL--- 1631

Query: 679  HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEA 728
               + DS ++  E  I+ L K L+A   + + ++++ +    ++ A           +EA
Sbjct: 1632 ---QADSAIKGREEAIKQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687

Query: 729  QVHKLREELINVNSQRKQQLVELGLLREE-------------EKQR-----ATREHEIVV 770
             + +L+E+L      RKQ  +E   L EE             EK+R     A  E E+  
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747

Query: 771  NK--LKAESEKMKIELKKTHAAETEMTLEK--------ANSKLKQIEKEYTQKL------ 814
             +  ++A S++++   ++      E+  E+        A  +L++  KE   KL      
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807

Query: 815  --AKSSQIIAELQTTISSLKEENSQQ----QLAA------ERRLQDVRQKFEDEKKQLIR 862
              +K    IA L+  I+ L+E+  Q+    Q A       +++L+++  + EDE+K   +
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 863  DNDQA---------IKVLQDELENRSNQVRCAEKKLQHKELESQE 898
              +QA         +K   +E E  S ++    +KLQ +  E+ E
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912



 Score =  123 bits (308), Expect = 9e-28
 Identities = 163/731 (22%), Positives = 324/731 (44%), Gaps = 134/731 (18%)

Query: 274  KLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETK 333
            ++Q K D ++QK  ER+     ELK L +     TEE    L++++Q    + ++  E +
Sbjct: 853  EMQAKED-ELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQLQA---ETELYAEAE 907

Query: 334  EDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQK--QHTENIQELLEDTNVR 391
            E ++    K  +Q  E + ++ E +L       +Q + + +K  Q   +++E LE+    
Sbjct: 908  EMRVRLAAK--KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 392  LNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSE 451
              K++ E +    +    IK+LE  +  L  + +N+ L +++ + E    ER   +T + 
Sbjct: 966  RQKLQLEKV----TAEAKIKKLEDEI--LVMDDQNNKLSKERKLLE----ERISDLTTNL 1015

Query: 452  LQEVKARRN--TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL 509
             +E +  +N   L  + + ++++ E  +K  + K   ++  LK++    AS     I +L
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADL 1074

Query: 510  EQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAH--DLQSELDKGKEDT 567
            +  + +LK QL + E + +  L   +++   + + LK I E + H  DLQ +LD      
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----- 1129

Query: 568  QKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK 627
                   E A + K E+          Q +     LE  K ++E   +   A  +E   K
Sbjct: 1130 -------ERAARNKAEK----------QKRDLGEELEALKTELEDTLDST-ATQQELRAK 1171

Query: 628  VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK---------THLLQQ 678
             E ++T  K   +++++    Q++++RQ++ Q + EL  + EQ K            L++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 679  HNAEKDSLVR---DHEREIENLEKQLRAANMEHENQIQEFKKR---DAQVIADMEAQVHK 732
             NA+    +R     ++E+E+ +K+L A       Q+QE + +     +  A++  +VHK
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEA-------QVQELQSKCSDGERARAELNDKVHK 1284

Query: 733  LREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAET 792
            L+ E+ +V           G+L E E +           KL  +   +  +L+ T     
Sbjct: 1285 LQNEVESVT----------GMLNEAEGKAI---------KLAKDVASLSSQLQDTQELLQ 1325

Query: 793  EMTLEKAN--SKLKQIEKEYTQ------------------------KLAKSSQIIAELQT 826
            E T +K N  +KL+Q+E+E                           +L+ S + + +  +
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385

Query: 827  TISSLKE---------ENSQQQ----LAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQ- 872
            T+ +L+E         EN  QQ     AA  +L+  + + + E   L+ D D   +++  
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445

Query: 873  -DELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPA-----SLRQELEDT 926
             ++ + + +Q+   EK +  K  + +++     +E ETK   L  A       ++ELE T
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 927  ISSLKSQVNFL 937
               LK+++  L
Sbjct: 1506 NKMLKAEMEDL 1516



 Score =  123 bits (308), Expect = 9e-28
 Identities = 187/820 (22%), Positives = 344/820 (41%), Gaps = 153/820 (18%)

Query: 250  SRIREKELDMKTKMME---------------AKFHEE---------KLKLQ-QKHDADVQ 284
            S I E E+ +K +                  + FHE+         +LK+Q  K + ++Q
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093

Query: 285  KILER-------KNNEIEELKTL-------------YRSKQHETEETIRKLEKKVQTLIR 324
              L R       KNN +++++ L              R+ +++ E+  R L ++++ L  
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1153

Query: 325  DC----------QVIRETKEDQIAELKKICEQST---ESLNNDWEKKLHNAVAEMEQ--E 369
            +           Q +R  +E ++  LKK  ++ T   E+   +  +K   AV E+ +  E
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213

Query: 370  KFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
            +F   K + +  ++ LE  N  L           Q   H  K+LEA+VQ+L  +  +   
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADIN 489
             R +L  +  +L+   +     L E + +   L K+   L +  +   +LLQ +    +N
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333

Query: 490  L---LKQEHALSASKASSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQ 534
            +   L+Q      S    + EE      LE+++  L  QL +S+ + +      + L + 
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393

Query: 535  ENKFQMEKSHLKHIYEKKA-----------------HDLQSELDKGKE---DTQKKIHKF 574
            + +FQ E  +L   YE+KA                  DL  +LD  ++   + +KK  KF
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453

Query: 575  EEALKEKE-------------EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
            ++ L E++             E   R  E + L   +A     E K ++E  ++ + AEM
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513

Query: 622  ------KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL 675
                  K+ + K   +L +SK   E Q +E   QLE++     Q   + KL  E     L
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQAL 1572

Query: 676  LQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------D 725
              Q   E+D   RD +   E   +QL+    E+E ++++ +K+ A   A          D
Sbjct: 1573 KGQF--ERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628

Query: 726  MEAQVH---KLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKI 782
            +E Q     K REE I     RK Q       RE E  RA+R+ EI     + E +   +
Sbjct: 1629 LELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRD-EIFATAKENEKKAKSL 1685

Query: 783  ELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQ--QL 840
            E       E     E+A  +    ++E  ++LA             SSL   N+ Q  + 
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELA-------------SSLSGRNALQDEKR 1732

Query: 841  AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI 900
              E R+  + ++ E+E+  +   +D+  K  Q + E  SN++   E+    K   +++Q+
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNEL-ATERSTAQKNESARQQL 1790

Query: 901  TYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKR 940
                +E  +KL   M  +++ + + TI++L++++  L+++
Sbjct: 1791 ERQNKELRSKLHE-MEGAVKSKFKSTIAALEAKIAQLEEQ 1829



 Score =  122 bits (305), Expect = 2e-27
 Identities = 183/779 (23%), Positives = 324/779 (41%), Gaps = 120/779 (15%)

Query: 271  EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIR 330
            +K++  + H +D+Q+ L+ +     + +   R    E E    +LE  + +     Q +R
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELR 1169

Query: 331  ETKEDQIAELKKICEQSTESLN---NDWEKKLHNAVAEMEQ--EKFDLQKQHTENIQELL 385
              +E ++  LKK  ++ T S      +  +K   AV E+ +  E+F   K + +  ++ L
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229

Query: 386  EDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
            E  N  L           Q   H  K+LEA+VQ+L  +  +    R +L  +  +L+   
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 446  QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINL---LKQEHALSASKA 502
            +     L E + +   L K+   L +  +   +LLQ +    +N+   L+Q      S  
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 503  SSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQENKFQMEKSHLKHIYE 550
              + EE      LE+++  L  QL +S+ + +      + L + + +FQ E  +L   YE
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 551  KKA-----------------HDLQSELDKGKE---DTQKKIHKFEEALKEKE-------- 582
            +KA                  DL  +LD  ++   + +KK  KF++ L E++        
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 583  -----EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM------KEQMEKVEAD 631
                 E   R  E + L   +A     E K ++E  ++ + AEM      K+ + K   +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529

Query: 632  LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE 691
            L +SK   E Q +E   QLE++     Q   + KL  E     L  Q   E+D   RD +
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQF--ERDLQARDEQ 1586

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEAQVH---KLREELI 738
             E +   +QL+    E+E ++++ +K+ A   A          D+E Q     K REE I
Sbjct: 1587 NEEKR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 739  NVNSQRKQQLVELGLLREEEKQRATREHEIVV---NKLKAESEKMKIELKKTHAAETEMT 795
                 RK Q       RE E  RA+R+        N+ KA+S +  +   +   A  E  
Sbjct: 1645 K--QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 796  LEKANSKLKQIEKEYTQKLAKSSQIIAE---LQTTISSLKEENSQQQLAAERRLQDVR-- 850
             ++A+ + +++ +E    L+  + +  E   L+  I+ L+EE  ++Q   E     VR  
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762

Query: 851  ------------------QKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK---- 888
                              QK E  ++QL R N    K L+ +L      V+   K     
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 889  LQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
            L+ K  + +EQ+     E E + K     SL+Q+ +  +  +  QV   +K A   +E+
Sbjct: 1819 LEAKIAQLEEQV-----EQEAREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQ 1871



 Score =  121 bits (303), Expect = 4e-27
 Identities = 170/787 (21%), Positives = 359/787 (45%), Gaps = 109/787 (13%)

Query: 251  RIREKELDMKTKMMEAKFHEEKLKLQQ-KHDADVQK------ILERKNNEIEELKTLYRS 303
            ++ ++ LD++ ++ E +   +KL+L++   +A ++K      +++ +NN++ + + L   
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006

Query: 304  K----------QHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNN 353
            +          + E  + + KL+ K +++I + +V  + +E    EL+K+ ++  E   +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL-KRKLEGDAS 1065

Query: 354  DWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKEL 413
            D+ +++ +  A++ + K  L K+         E+    L +++ E +AQ  +    I+EL
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKE--------EELQAALARLDDE-IAQKNNALKKIREL 1116

Query: 414  EARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV---KARRNTLHKEKDHLV 470
            E  +  L  + ++    R K  ++K +L    +   +EL++     A +  L  +++  V
Sbjct: 1117 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1176

Query: 471  NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQ---NVCQLKQQLQESELQR 527
               ++ +      ++A +  ++Q+HA +  + +  +E+ ++   N+ + KQ L++     
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 528  KQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKE---DTQKKIHKFEEA------- 577
              +LR    + + E  H K   E +  +LQS+   G+    +   K+HK +         
Sbjct: 1237 AGELRVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295

Query: 578  LKEKEEQLTRVT-EVQRLQAQQADAA--LEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
            L E E +  ++  +V  L +Q  D    L+E  RQ +LN      +++E+   ++  L  
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERNSLQDQLDE 1354

Query: 635  ---SKSLREKQSKEFLWQLEDIRQRYE------QQIVELKLEHEQEKTHLLQQHNAEKDS 685
               +K   E+       QL D +++ +      + + E K   ++E  +L QQ+  EK +
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAA 1413

Query: 686  LVRDHEREIENLEKQLRAANMEHENQ------IQEFKKRDAQVIADMEAQVHKLREELIN 739
                 E+    L+++L    ++ +NQ      +++ +++  Q++A+ +    K  +E   
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473

Query: 740  VNSQ-RKQQLVELGLLRE-EEKQRATREHEIVVNKLKAESE----------KMKIELKKT 787
              ++ R+++   L L R  EE   A  E E     LKAE E          K   EL+K+
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533

Query: 788  -HAAETEMT-----LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLA 841
              A ET+M      LE+   +L+  E    +       +  + +  + +  E+N +++  
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 842  AERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK----------KLQ- 890
             +R+L +   + EDE+KQ       A K L+ +L++   Q   A K          KLQ 
Sbjct: 1594 LQRQLHEYETELEDERKQRAL-AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652

Query: 891  -----HKELE----SQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRA 941
                  +ELE    S+++I    +E E K K L  A L Q  ED  ++ ++     +K+A
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERA-----RKQA 1706

Query: 942  SILQEEL 948
             + +EEL
Sbjct: 1707 DLEKEEL 1713



 Score =  120 bits (301), Expect = 6e-27
 Identities = 152/742 (20%), Positives = 345/742 (46%), Gaps = 83/742 (11%)

Query: 257  LDMKTKMMEAKFHEEKLKLQQKHDADVQKILERK---------NNEIEELKTLYRSKQHE 307
            L  K + +E   HE + +L+++ D   Q   ERK           ++EE +   +  Q E
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 308  ---TEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK------KICEQSTESLNNDWEKK 358
                E  I+KLE ++  L+ D Q  + +KE ++ E +       + E+  ++ N    K 
Sbjct: 973  KVTAEAKIKKLEDEI--LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030

Query: 359  LHNAV---AEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEA 415
             H ++    E+  +K +  +Q  E ++  LE      ++  ++  AQ       + + E 
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090

Query: 416  RVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ 475
             +Q      ++   Q+   +++  ELE        +L   +A RN   K+K     D  +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK----RDLGE 1146

Query: 476  NMKLLQTKYDADINLLKQEHALSASK-------ASSMIEELEQNVCQLKQQLQESELQRK 528
             ++ L+T+ +  ++    +  L A +         ++ EE   +  Q+ Q++++   Q  
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV-QEMRQKHAQAV 1205

Query: 529  QQLRDQENKFQMEKSHL---KHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQL 585
            ++L +Q  +F+  K++L   K   EK+  DL  EL    +  Q+  HK ++   + +E  
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265

Query: 586  TRVTEVQRLQAQQADAALEEFKRQVE-----LN-SEKVYAEMKEQMEKVEADLTRSKSLR 639
            ++ ++ +R +A+  D  + + + +VE     LN +E    ++ + +  + + L  ++ L 
Sbjct: 1266 SKCSDGERARAELND-KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324

Query: 640  EKQSKEFLWQLEDIRQ-RYEQQIVELKLEHEQEKTHLLQQH-------NAEKDSLVRDHE 691
            ++++++ L     +RQ   E+  ++ +L+ E E    L++H        ++    ++D  
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREEL--INVNSQRKQQLV 749
              +E LE+  +    E EN  Q+++++ A     +E   ++L++EL  + V+   ++QLV
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443

Query: 750  ELGLLREEEKQRATREHEIVVNKLKAESEKMKIEL--KKTHAAETEMTLEKANSKLKQIE 807
                 ++ +  +   E + + +K   E ++ + E   K+T A      LE+A    +++E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503

Query: 808  KEYTQKLAKSSQIIAELQTTISSLKE------ENSQQQLAAERRLQDVRQKFEDEKKQLI 861
            +  T K+ K     AE++  +SS  +      E  + + A E ++++++ + E+ + +L 
Sbjct: 1504 R--TNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556

Query: 862  RDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQ---EYETKLKG----- 913
               D  ++ L+  ++    Q    E+ LQ ++ +++E+   +++   EYET+L+      
Sbjct: 1557 ATEDAKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612

Query: 914  LMPASLRQELEDTISSLKSQVN 935
             + A+ +++LE  +  L+ Q +
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQAD 1634



 Score =  108 bits (271), Expect = 2e-23
 Identities = 141/723 (19%), Positives = 334/723 (46%), Gaps = 96/723 (13%)

Query: 163  GKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLR 222
            G+LRV   +      +  + +  ++ E+ SK S      +++  +++     +E+   + 
Sbjct: 1238 GELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296

Query: 223  QKPIPVSLMTPKFSLRKSSSFHD-DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDA 281
             +    ++   K     SS   D    L     ++L++ TK+ + +     L+ Q   + 
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356

Query: 282  DVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK 341
            + ++ LER  + +    +  + K  +   T+  LE+  +   ++ + + +  E++ A   
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416

Query: 342  KICEQSTESLNNDWEKKLHNAVAEMEQEK---FDLQKQHTENIQELLEDTNVRLNKMESE 398
            K+     E   N  +++L + V +++ ++    +L+K+  +  Q L E+ N+      S+
Sbjct: 1417 KL-----EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-----SSK 1466

Query: 399  YMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKAR 458
            Y  +        +E E +   L    E +       ++ K ELER  ++  +E++++ + 
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1519

Query: 459  RNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ-EHALSASKASSMIEELEQNVCQLK 517
            ++ + K     V++ E++ + L+T+ +     L++ E  L A++ + +   LE N+  LK
Sbjct: 1520 KDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL--RLEVNMQALK 1573

Query: 518  QQLQ-------ESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKK 570
             Q +       E   ++++QL+ Q ++++ E        E+K   L +   K  E   K 
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKD 1628

Query: 571  IH-KFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVE---LNSEKVYAEMKEQME 626
            +  + + A+K +EE    + ++++LQAQ  D     F+R++E    + ++++A  KE  +
Sbjct: 1629 LELQADSAIKGREEA---IKQLRKLQAQMKD-----FQRELEDARASRDEIFATAKENEK 1680

Query: 627  K---VEADLT----------RSKSLREKQSKEFLWQL----------EDIRQRYEQQIVE 663
            K   +EADL           R++   + + +E   +L          +D ++R E +I +
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 664  LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQL---RAANMEHENQIQEFKKRDA 720
            L+ E E+E+ ++     A  D  VR   ++ E L  +L   R+   ++E+  Q+ ++++ 
Sbjct: 1741 LEEELEEEQGNM----EAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            ++ + +      ++ +  +  +  + ++ +L    EE+ ++  RE +     LK + +K+
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAATKSLKQKDKKL 1851

Query: 781  K-----IELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA---ELQTTISSLK 832
            K     +E ++  A + +   EK N+++KQ++++  +   +S +I A   +LQ  +    
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911

Query: 833  EEN 835
            E N
Sbjct: 1912 ESN 1914



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 120/542 (22%), Positives = 229/542 (42%), Gaps = 107/542 (19%)

Query: 254  EKELDMKTKMMEAK------FHEEKLKLQQKHDADVQKI---------LERKNNEIEEL- 297
            +KE++  T+  E K        + K +LQQ+ D  V  +         LE+K  + ++L 
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 298  ------KTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESL 351
                   + Y  ++   E   R+ E K  +L R  +   E KE+ +    K+ +   E L
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDL 1516

Query: 352  ---NNDWEKKLHNA-----VAEMEQEKFDLQKQHTENIQELLEDTNVRLN--------KM 395
                +D  K +H         E + E+   Q +  E+  +  ED  +RL         + 
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 396  ESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV 455
            E +  A+ +      ++L+ ++ +   E E+   QR      K +LE        +L+++
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE-------GDLKDL 1629

Query: 456  KARRNTLHKEKDHLVNDYEQ---NMKLLQTKYDADINLLKQEHALSASKASSMIEELEQN 512
            + + ++  K ++  +    +    MK  Q + + D    + E   +A +     + LE +
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAKENEKKAKSLEAD 1688

Query: 513  VCQLKQQLQESELQRKQQLRDQE-------------NKFQMEKSHLKHIYEKKAHDLQSE 559
            + QL++ L  +E  RKQ   ++E             N  Q EK  L    E +   L+ E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL----EARIAQLEEE 1744

Query: 560  LDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQ-VELNS---- 614
            L++ + + +    +  +A ++ E QL+     +R  AQ+ ++A ++ +RQ  EL S    
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAE-QLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1803

Query: 615  ----------------EKVYAEMKEQMEKVEAD---LTRSKSLREKQSKEFLWQLEDIRQ 655
                            E   A+++EQ+E+   +    T+S   ++K+ KE L Q+ED R+
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1863

Query: 656  RYEQ----------QIVELK--LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRA 703
              EQ          ++ +LK  LE  +E++   Q+ NA +  L R+ +   E+ E   R 
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINANRRKLQRELDEATESNEAMGRE 1920

Query: 704  AN 705
             N
Sbjct: 1921 VN 1922



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 39/178 (21%), Positives = 89/178 (50%), Gaps = 14/178 (7%)

Query: 773  LKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK 832
            L+   ++ +++ K+    +T+   +KA ++LK++E++++Q   + + +  +LQ       
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ------- 897

Query: 833  EENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHK 892
               ++ +L AE     VR      KKQ + +    ++   +E E+R  Q++   KK+  +
Sbjct: 898  ---AETELYAEAEEMRVRLA---AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 893  ELESQEQITYIRQ-EYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELT 949
             L+ +EQ+        + +L+ +   +  ++LED I  +  Q N L K   +L+E ++
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 52/214 (24%), Positives = 90/214 (42%), Gaps = 52/214 (24%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETE--- 309
            R ++   + + +  +   E+   Q+   A  Q  LER+N E+       RSK HE E   
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQ--LERQNKEL-------RSKLHEMEGAV 1808

Query: 310  -----ETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVA 364
                  TI  LE K+  L  + QV +E +E Q A         T+SL    +KKL   + 
Sbjct: 1809 KSKFKSTIAALEAKIAQL--EEQVEQEAREKQAA---------TKSLKQK-DKKLKEILL 1856

Query: 365  EMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEA 424
            ++E E+                       KM  +Y  Q +  N  +K+L+ ++++   E+
Sbjct: 1857 QVEDER-----------------------KMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893

Query: 425  ENSNLQRQKLIQEKAELERCYQITCSELQEVKAR 458
            +  N  R+KL +E  E     +    E+  +K++
Sbjct: 1894 QRINANRRKLQRELDEATESNEAMGREVNALKSK 1927


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  125 bits (314), Expect = 2e-28
 Identities = 154/670 (22%), Positives = 294/670 (43%), Gaps = 99/670 (14%)

Query: 314  KLEKKVQTLIRDCQVIRETKEDQIAE--LKKICEQSTESLNNDWEKKLHNAVAEMEQEKF 371
            +L  KV+ L+   QV R+ +E Q  E  L+K  E+         ++K  N + E+EQ+  
Sbjct: 843  RLFTKVKPLL---QVTRQEEEMQAKEDELQKTKER---------QQKAENELKELEQKHS 890

Query: 372  DLQKQHTENIQELLEDTNV--RLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
             L ++     ++L  +T +     +M     A+ Q    ++ E+EAR+++     +    
Sbjct: 891  QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 950

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKY---DA 486
            +R+K+ Q+  +LE        +L+E +A R  L  EK       E  +K L+ +    D 
Sbjct: 951  ERKKMAQQMLDLEE-------QLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDD 999

Query: 487  DINLLKQEHALSASKASSMI------EELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
              N L +E  L   + S +       EE  +N+ +LK +  ES +   +    +E K + 
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEEKSRQ 1058

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQAD 600
            E   LK   E  A D   ++     D Q +I + +  L +KEE+L           Q A 
Sbjct: 1059 ELEKLKRKLEGDASDFHEQI----ADLQAQIAELKMQLAKKEEEL-----------QAAL 1103

Query: 601  AALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQ 660
            A L++   Q   N+ K   E++  +  ++ DL   ++ R K  K    Q  D+ +  E +
Sbjct: 1104 ARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGE--ELE 1156

Query: 661  IVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDA 720
             ++ +LE   + T   Q+  A++       E+E+  L+K L      HE Q+QE +++ A
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKR-------EQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            Q + ++  Q+ + +    N++  ++    E   L  E +     + E+   K K E++  
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269

Query: 781  KIELKKTHAAETEMTLEKANSKLKQIEKEYTQ-------------KLAKS-SQIIAELQT 826
            +++ K    ++ E    + N K+ +++ E                KLAK  + + ++LQ 
Sbjct: 1270 ELQSK---CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 827  TISSLKEENSQQQLAAE--RRLQDVRQKFED------EKKQLIRDNDQAIKVLQDELENR 878
            T   L+EE  Q+   +   R+L++ R   +D      E KQ +  +   + +   + + +
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 879  SNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGL-----MPASLRQELEDTISSLKSQ 933
                    + L+  +   Q++I  + Q+YE K             L+QEL+D +  L +Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 934  ---VNFLQKR 940
               V+ L+K+
Sbjct: 1447 RQLVSNLEKK 1456



 Score =  125 bits (313), Expect = 2e-28
 Identities = 169/765 (22%), Positives = 335/765 (43%), Gaps = 148/765 (19%)

Query: 252  IREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKI--------------------LERKN 291
            + +K LD +T+  EA+  E    ++QKH   V+++                    LE++N
Sbjct: 1185 VLKKALDEETRSHEAQVQE----MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240

Query: 292  NEIE-ELKTLYRSKQHETEETIRKLEKKVQTLIRDC---QVIRETKEDQIAELKKICEQS 347
             ++  EL+ L ++KQ E E   +KLE +VQ L   C   +  R    D++ +L+   E  
Sbjct: 1241 ADLAGELRVLGQAKQ-EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299

Query: 348  TESLNNDWEK--KLHNAVAEMEQEKFDLQKQHTEN----------IQELLEDTNVRLNKM 395
            T  LN    K  KL   VA +  +  D Q+   E           +++L E+ N   +++
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359

Query: 396  ESEYMAQTQSTNHM------IKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 449
            + E  A+     H+      + + + ++Q      E     +++  +E   L + Y+   
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419

Query: 450  SELQEVKARRNTLHKEKDHLVNDYEQNMKLL------QTKYD---ADINLLKQEHALSAS 500
            +   +++  +N L +E D LV D +   +L+      Q K+D   A+   +  ++A    
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479

Query: 501  KASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSEL 560
            +A +   E E     L + L+E+ L+ K++L   E   +M K+ ++            +L
Sbjct: 1480 RAEAEAREKETKALSLARALEEA-LEAKEEL---ERTNKMLKAEME------------DL 1523

Query: 561  DKGKEDTQKKIHKFEEALKEKEEQLTRV-TEVQRLQAQQADAALEEFKRQVELNSEKVYA 619
               K+D  K +H+ E++ +  E Q+  + T+++ L+ +    A E+ K ++E+N + +  
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ--ATEDAKLRLEVNMQALKG 1581

Query: 620  EMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR-QRYEQQIVELKLEHEQEKTHLLQQ 678
            + +  ++  +      +   ++Q  E+  +LED R QR      + KLE + +   L   
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL--- 1638

Query: 679  HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEA 728
               + DS ++  E  I+ L K L+A   + + ++++ +    ++ A           +EA
Sbjct: 1639 ---QADSAIKGREEAIKQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694

Query: 729  QVHKLREELINVNSQRKQQLVELGLLREE-------------EKQR-----ATREHEIVV 770
             + +L+E+L      RKQ  +E   L EE             EK+R     A  E E+  
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754

Query: 771  NK--LKAESEKMKIELKKTHAAETEMTLEK--------ANSKLKQIEKEYTQKL------ 814
             +  ++A S++++   ++      E+  E+        A  +L++  KE   KL      
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814

Query: 815  --AKSSQIIAELQTTISSLKEENSQQ----QLAA------ERRLQDVRQKFEDEKKQLIR 862
              +K    IA L+  I+ L+E+  Q+    Q A       +++L+++  + EDE+K   +
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 863  DNDQA---------IKVLQDELENRSNQVRCAEKKLQHKELESQE 898
              +QA         +K   +E E  S ++    +KLQ +  E+ E
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919



 Score =  123 bits (308), Expect = 9e-28
 Identities = 163/731 (22%), Positives = 324/731 (44%), Gaps = 134/731 (18%)

Query: 274  KLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETK 333
            ++Q K D ++QK  ER+     ELK L +     TEE    L++++Q    + ++  E +
Sbjct: 860  EMQAKED-ELQKTKERQQKAENELKELEQKHSQLTEEK-NLLQEQLQA---ETELYAEAE 914

Query: 334  EDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQK--QHTENIQELLEDTNVR 391
            E ++    K  +Q  E + ++ E +L       +Q + + +K  Q   +++E LE+    
Sbjct: 915  EMRVRLAAK--KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 392  LNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSE 451
              K++ E +    +    IK+LE  +  L  + +N+ L +++ + E    ER   +T + 
Sbjct: 973  RQKLQLEKV----TAEAKIKKLEDEI--LVMDDQNNKLSKERKLLE----ERISDLTTNL 1022

Query: 452  LQEVKARRN--TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL 509
             +E +  +N   L  + + ++++ E  +K  + K   ++  LK++    AS     I +L
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADL 1081

Query: 510  EQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAH--DLQSELDKGKEDT 567
            +  + +LK QL + E + +  L   +++   + + LK I E + H  DLQ +LD      
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----- 1136

Query: 568  QKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK 627
                   E A + K E+          Q +     LE  K ++E   +   A  +E   K
Sbjct: 1137 -------ERAARNKAEK----------QKRDLGEELEALKTELEDTLDST-ATQQELRAK 1178

Query: 628  VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK---------THLLQQ 678
             E ++T  K   +++++    Q++++RQ++ Q + EL  + EQ K            L++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 679  HNAEKDSLVR---DHEREIENLEKQLRAANMEHENQIQEFKKR---DAQVIADMEAQVHK 732
             NA+    +R     ++E+E+ +K+L A       Q+QE + +     +  A++  +VHK
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEA-------QVQELQSKCSDGERARAELNDKVHK 1291

Query: 733  LREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAET 792
            L+ E+ +V           G+L E E +           KL  +   +  +L+ T     
Sbjct: 1292 LQNEVESVT----------GMLNEAEGKAI---------KLAKDVASLSSQLQDTQELLQ 1332

Query: 793  EMTLEKAN--SKLKQIEKEYTQ------------------------KLAKSSQIIAELQT 826
            E T +K N  +KL+Q+E+E                           +L+ S + + +  +
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392

Query: 827  TISSLKE---------ENSQQQ----LAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQ- 872
            T+ +L+E         EN  QQ     AA  +L+  + + + E   L+ D D   +++  
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 873  -DELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPA-----SLRQELEDT 926
             ++ + + +Q+   EK +  K  + +++     +E ETK   L  A       ++ELE T
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 927  ISSLKSQVNFL 937
               LK+++  L
Sbjct: 1513 NKMLKAEMEDL 1523



 Score =  123 bits (308), Expect = 9e-28
 Identities = 187/820 (22%), Positives = 344/820 (41%), Gaps = 153/820 (18%)

Query: 250  SRIREKELDMKTKMME---------------AKFHEE---------KLKLQ-QKHDADVQ 284
            S I E E+ +K +                  + FHE+         +LK+Q  K + ++Q
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100

Query: 285  KILER-------KNNEIEELKTL-------------YRSKQHETEETIRKLEKKVQTLIR 324
              L R       KNN +++++ L              R+ +++ E+  R L ++++ L  
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1160

Query: 325  DC----------QVIRETKEDQIAELKKICEQST---ESLNNDWEKKLHNAVAEMEQ--E 369
            +           Q +R  +E ++  LKK  ++ T   E+   +  +K   AV E+ +  E
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220

Query: 370  KFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNL 429
            +F   K + +  ++ LE  N  L           Q   H  K+LEA+VQ+L  +  +   
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280

Query: 430  QRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADIN 489
             R +L  +  +L+   +     L E + +   L K+   L +  +   +LLQ +    +N
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340

Query: 490  L---LKQEHALSASKASSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQ 534
            +   L+Q      S    + EE      LE+++  L  QL +S+ + +      + L + 
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400

Query: 535  ENKFQMEKSHLKHIYEKKA-----------------HDLQSELDKGKE---DTQKKIHKF 574
            + +FQ E  +L   YE+KA                  DL  +LD  ++   + +KK  KF
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460

Query: 575  EEALKEKE-------------EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
            ++ L E++             E   R  E + L   +A     E K ++E  ++ + AEM
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520

Query: 622  ------KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL 675
                  K+ + K   +L +SK   E Q +E   QLE++     Q   + KL  E     L
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQAL 1579

Query: 676  LQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------D 725
              Q   E+D   RD +   E   +QL+    E+E ++++ +K+ A   A          D
Sbjct: 1580 KGQF--ERDLQARDEQN--EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635

Query: 726  MEAQVH---KLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKI 782
            +E Q     K REE I     RK Q       RE E  RA+R+ EI     + E +   +
Sbjct: 1636 LELQADSAIKGREEAI--KQLRKLQAQMKDFQRELEDARASRD-EIFATAKENEKKAKSL 1692

Query: 783  ELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQ--QL 840
            E       E     E+A  +    ++E  ++LA             SSL   N+ Q  + 
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELA-------------SSLSGRNALQDEKR 1739

Query: 841  AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI 900
              E R+  + ++ E+E+  +   +D+  K  Q + E  SN++   E+    K   +++Q+
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNEL-ATERSTAQKNESARQQL 1797

Query: 901  TYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKR 940
                +E  +KL   M  +++ + + TI++L++++  L+++
Sbjct: 1798 ERQNKELRSKLHE-MEGAVKSKFKSTIAALEAKIAQLEEQ 1836



 Score =  122 bits (305), Expect = 2e-27
 Identities = 183/779 (23%), Positives = 324/779 (41%), Gaps = 120/779 (15%)

Query: 271  EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIR 330
            +K++  + H +D+Q+ L+ +     + +   R    E E    +LE  + +     Q +R
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELR 1176

Query: 331  ETKEDQIAELKKICEQSTESLN---NDWEKKLHNAVAEMEQ--EKFDLQKQHTENIQELL 385
              +E ++  LKK  ++ T S      +  +K   AV E+ +  E+F   K + +  ++ L
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236

Query: 386  EDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY 445
            E  N  L           Q   H  K+LEA+VQ+L  +  +    R +L  +  +L+   
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 446  QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINL---LKQEHALSASKA 502
            +     L E + +   L K+   L +  +   +LLQ +    +N+   L+Q      S  
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 503  SSMIEE------LEQNVCQLKQQLQESELQRK------QQLRDQENKFQMEKSHLKHIYE 550
              + EE      LE+++  L  QL +S+ + +      + L + + +FQ E  +L   YE
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 551  KKA-----------------HDLQSELDKGKE---DTQKKIHKFEEALKEKE-------- 582
            +KA                  DL  +LD  ++   + +KK  KF++ L E++        
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 583  -----EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM------KEQMEKVEAD 631
                 E   R  E + L   +A     E K ++E  ++ + AEM      K+ + K   +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536

Query: 632  LTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE 691
            L +SK   E Q +E   QLE++     Q   + KL  E     L  Q   E+D   RD +
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQF--ERDLQARDEQ 1593

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIA----------DMEAQVH---KLREELI 738
             E +   +QL+    E+E ++++ +K+ A   A          D+E Q     K REE I
Sbjct: 1594 NEEKR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 739  NVNSQRKQQLVELGLLREEEKQRATREHEIVV---NKLKAESEKMKIELKKTHAAETEMT 795
                 RK Q       RE E  RA+R+        N+ KA+S +  +   +   A  E  
Sbjct: 1652 K--QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 796  LEKANSKLKQIEKEYTQKLAKSSQIIAE---LQTTISSLKEENSQQQLAAERRLQDVR-- 850
             ++A+ + +++ +E    L+  + +  E   L+  I+ L+EE  ++Q   E     VR  
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769

Query: 851  ------------------QKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKK---- 888
                              QK E  ++QL R N    K L+ +L      V+   K     
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQN----KELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 889  LQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
            L+ K  + +EQ+     E E + K     SL+Q+ +  +  +  QV   +K A   +E+
Sbjct: 1826 LEAKIAQLEEQV-----EQEAREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQ 1878



 Score =  121 bits (303), Expect = 4e-27
 Identities = 170/787 (21%), Positives = 359/787 (45%), Gaps = 109/787 (13%)

Query: 251  RIREKELDMKTKMMEAKFHEEKLKLQQ-KHDADVQK------ILERKNNEIEELKTLYRS 303
            ++ ++ LD++ ++ E +   +KL+L++   +A ++K      +++ +NN++ + + L   
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 304  K----------QHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNN 353
            +          + E  + + KL+ K +++I + +V  + +E    EL+K+ ++  E   +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL-KRKLEGDAS 1072

Query: 354  DWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKEL 413
            D+ +++ +  A++ + K  L K+         E+    L +++ E +AQ  +    I+EL
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKE--------EELQAALARLDDE-IAQKNNALKKIREL 1123

Query: 414  EARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV---KARRNTLHKEKDHLV 470
            E  +  L  + ++    R K  ++K +L    +   +EL++     A +  L  +++  V
Sbjct: 1124 EGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1183

Query: 471  NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQ---NVCQLKQQLQESELQR 527
               ++ +      ++A +  ++Q+HA +  + +  +E+ ++   N+ + KQ L++     
Sbjct: 1184 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 528  KQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKE---DTQKKIHKFEEA------- 577
              +LR    + + E  H K   E +  +LQS+   G+    +   K+HK +         
Sbjct: 1244 AGELRVL-GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302

Query: 578  LKEKEEQLTRVT-EVQRLQAQQADAA--LEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
            L E E +  ++  +V  L +Q  D    L+E  RQ +LN      +++E+   ++  L  
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERNSLQDQLDE 1361

Query: 635  ---SKSLREKQSKEFLWQLEDIRQRYE------QQIVELKLEHEQEKTHLLQQHNAEKDS 685
               +K   E+       QL D +++ +      + + E K   ++E  +L QQ+  EK +
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAA 1420

Query: 686  LVRDHEREIENLEKQLRAANMEHENQ------IQEFKKRDAQVIADMEAQVHKLREELIN 739
                 E+    L+++L    ++ +NQ      +++ +++  Q++A+ +    K  +E   
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480

Query: 740  VNSQ-RKQQLVELGLLRE-EEKQRATREHEIVVNKLKAESE----------KMKIELKKT 787
              ++ R+++   L L R  EE   A  E E     LKAE E          K   EL+K+
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540

Query: 788  -HAAETEMT-----LEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLA 841
              A ET+M      LE+   +L+  E    +       +  + +  + +  E+N +++  
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 842  AERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK----------KLQ- 890
             +R+L +   + EDE+KQ       A K L+ +L++   Q   A K          KLQ 
Sbjct: 1601 LQRQLHEYETELEDERKQRAL-AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659

Query: 891  -----HKELE----SQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRA 941
                  +ELE    S+++I    +E E K K L  A L Q  ED  ++ ++     +K+A
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERA-----RKQA 1713

Query: 942  SILQEEL 948
             + +EEL
Sbjct: 1714 DLEKEEL 1720



 Score =  120 bits (301), Expect = 6e-27
 Identities = 152/742 (20%), Positives = 345/742 (46%), Gaps = 83/742 (11%)

Query: 257  LDMKTKMMEAKFHEEKLKLQQKHDADVQKILERK---------NNEIEELKTLYRSKQHE 307
            L  K + +E   HE + +L+++ D   Q   ERK           ++EE +   +  Q E
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 308  ---TEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK------KICEQSTESLNNDWEKK 358
                E  I+KLE ++  L+ D Q  + +KE ++ E +       + E+  ++ N    K 
Sbjct: 980  KVTAEAKIKKLEDEI--LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037

Query: 359  LHNAV---AEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEA 415
             H ++    E+  +K +  +Q  E ++  LE      ++  ++  AQ       + + E 
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097

Query: 416  RVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ 475
             +Q      ++   Q+   +++  ELE        +L   +A RN   K+K     D  +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK----RDLGE 1153

Query: 476  NMKLLQTKYDADINLLKQEHALSASK-------ASSMIEELEQNVCQLKQQLQESELQRK 528
             ++ L+T+ +  ++    +  L A +         ++ EE   +  Q+ Q++++   Q  
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV-QEMRQKHAQAV 1212

Query: 529  QQLRDQENKFQMEKSHL---KHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQL 585
            ++L +Q  +F+  K++L   K   EK+  DL  EL    +  Q+  HK ++   + +E  
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 586  TRVTEVQRLQAQQADAALEEFKRQVE-----LN-SEKVYAEMKEQMEKVEADLTRSKSLR 639
            ++ ++ +R +A+  D  + + + +VE     LN +E    ++ + +  + + L  ++ L 
Sbjct: 1273 SKCSDGERARAELND-KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331

Query: 640  EKQSKEFLWQLEDIRQ-RYEQQIVELKLEHEQEKTHLLQQH-------NAEKDSLVRDHE 691
            ++++++ L     +RQ   E+  ++ +L+ E E    L++H        ++    ++D  
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 692  REIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREEL--INVNSQRKQQLV 749
              +E LE+  +    E EN  Q+++++ A     +E   ++L++EL  + V+   ++QLV
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450

Query: 750  ELGLLREEEKQRATREHEIVVNKLKAESEKMKIEL--KKTHAAETEMTLEKANSKLKQIE 807
                 ++ +  +   E + + +K   E ++ + E   K+T A      LE+A    +++E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 808  KEYTQKLAKSSQIIAELQTTISSLKE------ENSQQQLAAERRLQDVRQKFEDEKKQLI 861
            +  T K+ K     AE++  +SS  +      E  + + A E ++++++ + E+ + +L 
Sbjct: 1511 R--TNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563

Query: 862  RDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQ---EYETKLKG----- 913
               D  ++ L+  ++    Q    E+ LQ ++ +++E+   +++   EYET+L+      
Sbjct: 1564 ATEDAKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619

Query: 914  LMPASLRQELEDTISSLKSQVN 935
             + A+ +++LE  +  L+ Q +
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQAD 1641



 Score =  108 bits (271), Expect = 2e-23
 Identities = 141/723 (19%), Positives = 334/723 (46%), Gaps = 96/723 (13%)

Query: 163  GKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLR 222
            G+LRV   +      +  + +  ++ E+ SK S      +++  +++     +E+   + 
Sbjct: 1245 GELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303

Query: 223  QKPIPVSLMTPKFSLRKSSSFHD-DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDA 281
             +    ++   K     SS   D    L     ++L++ TK+ + +     L+ Q   + 
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363

Query: 282  DVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK 341
            + ++ LER  + +    +  + K  +   T+  LE+  +   ++ + + +  E++ A   
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423

Query: 342  KICEQSTESLNNDWEKKLHNAVAEMEQEK---FDLQKQHTENIQELLEDTNVRLNKMESE 398
            K+     E   N  +++L + V +++ ++    +L+K+  +  Q L E+ N+      S+
Sbjct: 1424 KL-----EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-----SSK 1473

Query: 399  YMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKAR 458
            Y  +        +E E +   L    E +       ++ K ELER  ++  +E++++ + 
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEA-------LEAKEELERTNKMLKAEMEDLVSS 1526

Query: 459  RNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ-EHALSASKASSMIEELEQNVCQLK 517
            ++ + K     V++ E++ + L+T+ +     L++ E  L A++ + +   LE N+  LK
Sbjct: 1527 KDDVGKN----VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL--RLEVNMQALK 1580

Query: 518  QQLQ-------ESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKK 570
             Q +       E   ++++QL+ Q ++++ E        E+K   L +   K  E   K 
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKKKLEGDLKD 1635

Query: 571  IH-KFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVE---LNSEKVYAEMKEQME 626
            +  + + A+K +EE    + ++++LQAQ  D     F+R++E    + ++++A  KE  +
Sbjct: 1636 LELQADSAIKGREEA---IKQLRKLQAQMKD-----FQRELEDARASRDEIFATAKENEK 1687

Query: 627  K---VEADLT----------RSKSLREKQSKEFLWQL----------EDIRQRYEQQIVE 663
            K   +EADL           R++   + + +E   +L          +D ++R E +I +
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 664  LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQL---RAANMEHENQIQEFKKRDA 720
            L+ E E+E+ ++     A  D  VR   ++ E L  +L   R+   ++E+  Q+ ++++ 
Sbjct: 1748 LEEELEEEQGNM----EAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802

Query: 721  QVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKM 780
            ++ + +      ++ +  +  +  + ++ +L    EE+ ++  RE +     LK + +K+
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAATKSLKQKDKKL 1858

Query: 781  K-----IELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA---ELQTTISSLK 832
            K     +E ++  A + +   EK N+++KQ++++  +   +S +I A   +LQ  +    
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918

Query: 833  EEN 835
            E N
Sbjct: 1919 ESN 1921



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 120/542 (22%), Positives = 229/542 (42%), Gaps = 107/542 (19%)

Query: 254  EKELDMKTKMMEAK------FHEEKLKLQQKHDADVQKI---------LERKNNEIEEL- 297
            +KE++  T+  E K        + K +LQQ+ D  V  +         LE+K  + ++L 
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 298  ------KTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESL 351
                   + Y  ++   E   R+ E K  +L R  +   E KE+ +    K+ +   E L
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDL 1523

Query: 352  ---NNDWEKKLHNA-----VAEMEQEKFDLQKQHTENIQELLEDTNVRLN--------KM 395
                +D  K +H         E + E+   Q +  E+  +  ED  +RL         + 
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 396  ESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEV 455
            E +  A+ +      ++L+ ++ +   E E+   QR      K +LE        +L+++
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE-------GDLKDL 1636

Query: 456  KARRNTLHKEKDHLVNDYEQ---NMKLLQTKYDADINLLKQEHALSASKASSMIEELEQN 512
            + + ++  K ++  +    +    MK  Q + + D    + E   +A +     + LE +
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAKENEKKAKSLEAD 1695

Query: 513  VCQLKQQLQESELQRKQQLRDQE-------------NKFQMEKSHLKHIYEKKAHDLQSE 559
            + QL++ L  +E  RKQ   ++E             N  Q EK  L    E +   L+ E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL----EARIAQLEEE 1751

Query: 560  LDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQ-VELNS---- 614
            L++ + + +    +  +A ++ E QL+     +R  AQ+ ++A ++ +RQ  EL S    
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAE-QLSNELATERSTAQKNESARQQLERQNKELRSKLHE 1810

Query: 615  ----------------EKVYAEMKEQMEKVEAD---LTRSKSLREKQSKEFLWQLEDIRQ 655
                            E   A+++EQ+E+   +    T+S   ++K+ KE L Q+ED R+
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1870

Query: 656  RYEQ----------QIVELK--LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRA 703
              EQ          ++ +LK  LE  +E++   Q+ NA +  L R+ +   E+ E   R 
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEES---QRINANRRKLQRELDEATESNEAMGRE 1927

Query: 704  AN 705
             N
Sbjct: 1928 VN 1929



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 39/178 (21%), Positives = 89/178 (50%), Gaps = 14/178 (7%)

Query: 773  LKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK 832
            L+   ++ +++ K+    +T+   +KA ++LK++E++++Q   + + +  +LQ       
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ------- 904

Query: 833  EENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHK 892
               ++ +L AE     VR      KKQ + +    ++   +E E+R  Q++   KK+  +
Sbjct: 905  ---AETELYAEAEEMRVRLA---AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 893  ELESQEQITYIRQ-EYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELT 949
             L+ +EQ+        + +L+ +   +  ++LED I  +  Q N L K   +L+E ++
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 52/214 (24%), Positives = 90/214 (42%), Gaps = 52/214 (24%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETE--- 309
            R ++   + + +  +   E+   Q+   A  Q  LER+N E+       RSK HE E   
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQ--LERQNKEL-------RSKLHEMEGAV 1815

Query: 310  -----ETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVA 364
                  TI  LE K+  L  + QV +E +E Q A         T+SL    +KKL   + 
Sbjct: 1816 KSKFKSTIAALEAKIAQL--EEQVEQEAREKQAA---------TKSLKQK-DKKLKEILL 1863

Query: 365  EMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEA 424
            ++E E+                       KM  +Y  Q +  N  +K+L+ ++++   E+
Sbjct: 1864 QVEDER-----------------------KMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 425  ENSNLQRQKLIQEKAELERCYQITCSELQEVKAR 458
            +  N  R+KL +E  E     +    E+  +K++
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALKSK 1934


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score =  125 bits (314), Expect = 2e-28
 Identities = 157/720 (21%), Positives = 316/720 (43%), Gaps = 118/720 (16%)

Query: 251  RIREKELDMKTKMMEAKFHEEKL---KLQQKHDADVQKILERKNNEIEELKTLYRSKQHE 307
            R+    L+ +   + ++  +E+       Q  DA+  + L R   E++EL+T Y + + +
Sbjct: 1281 RLNSDRLESRISELTSELTDERNTGESASQLLDAETAERL-RAEKEMKELQTQYDALKKQ 1339

Query: 308  TEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEME 367
             E  + ++E     LIR  ++  E  +D                  +W  K   AV E++
Sbjct: 1340 ME--VMEMEVMEARLIRAAEINGEVDDDDAG--------------GEWRLKYERAVREVD 1383

Query: 368  QEKFDLQKQHTENIQELLEDTNVR-LNKMESEYMAQTQSTNHMIKELEARVQQLTGEAEN 426
              K  LQ++  + ++  +E  N R L +   +  A ++ +   +++L+ + Q+LT E ++
Sbjct: 1384 FTKKRLQQEFEDKLE--VEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD 1441

Query: 427  SNLQRQKLIQEKAELERCYQITCSEL-------QEVKARRNTLHKEKDHLVND------- 472
            + L  +       ELE+  +   SEL       Q  K +R  L +EKD L+ +       
Sbjct: 1442 TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQ 1501

Query: 473  ----------YEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE 522
                      + Q +  L+ +   DI+  + +   S +K    + +LE  V   +++L E
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQ-DISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDE 1560

Query: 523  SELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKE 582
             +    Q L   + + +ME   ++  + K+      E+++ ++  QKK+ + E  L+E+ 
Sbjct: 1561 -QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEY 1619

Query: 583  EQLTRV------------------------------TEVQRLQAQQADAALEEFKRQVEL 612
            E   +V                               +++R +A  ADA L     +   
Sbjct: 1620 EDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSA 1679

Query: 613  NSEKVYAEMKEQMEKVE---ADLTRSKSLREKQSKEFLWQLEDI------------RQRY 657
             S++  A++K Q+E+ E   A   +++   E + ++   Q++DI            R + 
Sbjct: 1680 PSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQR 1739

Query: 658  EQQIVELKLEHEQE-KTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFK 716
            E+  ++ +LE +QE    L+++H A      RD   +I +L+ QL  AN E + ++QE  
Sbjct: 1740 EKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD-LAQINDLQAQLEEANKE-KQELQE-- 1795

Query: 717  KRDAQVIADMEAQVHKLREELINVN--SQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
                  +  +++QV  L + +++ +  S+++ ++ EL    E E+ +  R  E + ++LK
Sbjct: 1796 -----KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKR-LESLASRLK 1849

Query: 775  AESEKMKIELKKTHAAET-----EMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTIS 829
               EK+  E  +  AAE         L++     K+   E  +K A++S+   EL+  + 
Sbjct: 1850 ENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLE 1909

Query: 830  SLKEENSQQQL---AAERRLQDVRQKFEDEKKQLIRD---NDQAIKVLQDELENRSNQVR 883
            SL+  N   Q     A +R+ D++   EDE +    +   N +    +  ELE+R + V+
Sbjct: 1910 SLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVK 1969



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 152/704 (21%), Positives = 307/704 (43%), Gaps = 109/704 (15%)

Query: 299  TLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNN---DW 355
            TL R ++   E+T R L    Q   R     +  K+ +I +L   C Q     N    DW
Sbjct: 1176 TLARLEEQRDEQTSRNLTL-FQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDW 1234

Query: 356  EK-KLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELE 414
               KL   V  + + +  L ++   N  E ++    +L K E E      +++ +   + 
Sbjct: 1235 PWWKLFTTVRPLIEVQ--LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRIS 1292

Query: 415  ARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYE 474
                +LT E        Q L  E AE  R  +    E++E++ + + L K+ + +  +  
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEK----EMKELQTQYDALKKQMEVMEMEVM 1348

Query: 475  QNMKLLQTKYDADIN--------LLKQEHALSA---------SKASSMIEELEQNVCQLK 517
            +   +   + + +++         LK E A+            +    +E  +QN  QL+
Sbjct: 1349 EARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLE 1408

Query: 518  QQLQE-----SELQRK-QQLRD---------QENKFQMEKSHLK-HIYEKKAHDLQSELD 561
            ++L +      E QR  QQL+          Q+ K  +E   ++ H  EKK     SEL 
Sbjct: 1409 RRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELS 1468

Query: 562  KGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
            +  E+ Q++  + E+  +EK+  L     +++ Q ++ D  +  F ++V ++ E    ++
Sbjct: 1469 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQ-QLEEKDMDIAGFTQKV-VSLEAELQDI 1526

Query: 622  KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNA 681
              Q  K EA L + K    KQ ++   +++D  +  ++Q   +++  EQ K  L      
Sbjct: 1527 SSQESKDEASLAKVK----KQLRDLEAKVKDQEEELDEQAGTIQML-EQAKLRL----EM 1577

Query: 682  EKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVN 741
            E + + + H +E+E+ ++++  A    + ++   K+ + Q+  + E +   LRE+     
Sbjct: 1578 EMERMRQTHSKEMESRDEEVEEARQSCQKKL---KQMEVQLEEEYEDKQKVLREK----- 1629

Query: 742  SQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEK-MKIELKKTHAAETEMTLEKAN 800
                         RE E + AT   +  VN+   ESEK ++ +LK+T A   +       
Sbjct: 1630 -------------RELEGKLATLSDQ--VNRRDFESEKRLRKDLKRTKALLADA------ 1668

Query: 801  SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENS---QQQLAAERRLQDVRQKFED-- 855
                Q+  ++ +  A S + IA+L+  +   +   +   + + A E  ++D+  + +D  
Sbjct: 1669 ----QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIA 1724

Query: 856  EKKQLIRDNDQAIKVLQDELENR--SNQVRCAEKKLQHKELESQE-----QITYIRQEYE 908
            + K  + +    ++  ++E++NR   +Q    E   +HK   +Q      QI  ++ + E
Sbjct: 1725 KAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLE 1784

Query: 909  TKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
               K       +QEL++ + +L+SQV FL++  S++ + L + Q
Sbjct: 1785 EANKE------KQELQEKLQALQSQVEFLEQ--SMVDKSLVSRQ 1820



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 85/402 (21%), Positives = 201/402 (50%), Gaps = 36/402 (8%)

Query: 253  REKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTL---YRSKQHETE 309
            R++E++   +  + K  + +++L+++++ D QK+L  K     +L TL      +  E+E
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYE-DKQKVLREKRELEGKLATLSDQVNRRDFESE 1651

Query: 310  ETIRKLEKKVQTLIRDCQVIRE------TKEDQIAELKKICEQS--TESLNNDWEKKLHN 361
            + +RK  K+ + L+ D Q++ +        + +IA+LK   E+S  T +      K +  
Sbjct: 1652 KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEV 1711

Query: 362  AVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLT 421
             + ++  +  D+ K  T  ++E L       N++++      +  N ++K+ +A V Q +
Sbjct: 1712 EIEDLHLQIDDIAKAKTA-LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQAS 1770

Query: 422  GE-AENSNLQRQ--KLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMK 478
             + A+ ++LQ Q  +  +EK EL+   Q   S+++ ++  ++ + K    LV+  E  ++
Sbjct: 1771 RDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLE--QSMVDKS---LVSRQEAKIR 1825

Query: 479  LLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKF 538
             L+T+ + +   +K+  +L++    +M +  E+   ++  + +E E  ++ Q + ++ K 
Sbjct: 1826 ELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKE 1885

Query: 539  QM-EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQ 597
            +M E +  +    +K H+L+ +L+  +   Q      + A K           +  LQA 
Sbjct: 1886 EMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFK----------RIGDLQAA 1935

Query: 598  QADAALEEFKRQVELNSE---KVYAEMKEQMEKVEADLTRSK 636
              D  +E  + +  +NSE    V +E++++++ V++ L+++K
Sbjct: 1936 IED-EMESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKNK 1976



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 58/316 (18%), Positives = 128/316 (40%), Gaps = 29/316 (9%)

Query: 654  RQRYEQQIV--ELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQ 711
            RQ Y   +V  E +   +    HL ++H   ++ +V D  R +E L   L   ++E  + 
Sbjct: 1109 RQGYPDHMVFSEFRRRFDVLAPHLTKKHG--RNYIVVDERRAVEEL---LECLDLEKSSC 1163

Query: 712  IQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVN 771
                 +   +  A   A++ + R+E  + N    Q      L R+  K+R  ++  I   
Sbjct: 1164 CMGLSRVFFR--AGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCV 1221

Query: 772  KLKAESEK-----------------MKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKL 814
            +   +  K                 ++++L +      +  +++  SKL++ EKE  +  
Sbjct: 1222 QKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELR 1281

Query: 815  AKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKK-QLIRDNDQAIKVLQD 873
              S ++ + +    S L +E +  + A++    +  ++   EK+ + ++    A+K   +
Sbjct: 1282 LNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQME 1341

Query: 874  ELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLK--GLMPASLRQELEDTISSLK 931
             +E    + R       + E++  +     R +YE  ++        L+QE ED +   +
Sbjct: 1342 VMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQ 1401

Query: 932  SQVNFLQKRASILQEE 947
                 L++R   LQ +
Sbjct: 1402 QNKRQLERRLGDLQAD 1417


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  124 bits (311), Expect = 4e-28
 Identities = 161/687 (23%), Positives = 307/687 (44%), Gaps = 100/687 (14%)

Query: 258  DMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRK--- 314
            +++T +   + +  K+   +K +  + K +E   NEI + K   ++ Q+ +++ +++   
Sbjct: 478  ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537

Query: 315  LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQ 374
            LEK ++TL       RE  E QI    KI EQ  E LN         +    E    D++
Sbjct: 538  LEKTIETL-------RENSERQI----KILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586

Query: 375  KQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKL 434
            K++ + + E +++T+ +L+K+E E     +   H  KE   R ++L  E  +   + + L
Sbjct: 587  KEN-KILHESIKETSSKLSKIEFEKRQIKKELEHY-KEKGERAEELENELHHLEKENELL 644

Query: 435  IQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQE 494
             ++   L+    ITC +++ ++   + L +E          N KL +T  D+  NL  Q 
Sbjct: 645  QKKITNLK----ITCEKIEALEQENSELERE----------NRKLKKT-LDSFKNLTFQL 689

Query: 495  HALSASKASSMIEE----LEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYE 550
             +L   K +S ++E    L +NV  LK         +  QL+ +  + + EK  LK   E
Sbjct: 690  ESLE--KENSQLDEENLELRRNVESLK-----CASMKMAQLQLENKELESEKEQLKKGLE 742

Query: 551  --KKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKR 608
              K +      L+   +    +  + ++ L+   ++      +Q+L+++  D  +E    
Sbjct: 743  LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK------IQQLESELQDLEMENQTL 796

Query: 609  QVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEH 668
            Q  L   K+ ++  EQ+EK    L +  S  EK  K+   + E+ R R + +I +  LE 
Sbjct: 797  QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL--EKENKRLRQQAEIKDTTLEE 854

Query: 669  EQEKTHLLQQHNAE--------KDSLVRDHEREIENLEKQLRAA------NMEHENQIQE 714
               K   L++ N          K+S VR  E E EN E   RA           E+ + E
Sbjct: 855  NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914

Query: 715  FKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
             K +  Q+  D+E   H+L  E I +N +R        LL +E  Q     ++++ +KL+
Sbjct: 915  -KLKTQQMNNDLEKLTHEL--EKIGLNKER--------LLHDE--QSTDDRYKLLESKLE 961

Query: 775  AESEKMKIELKKTHAAETEMTLEKANS-------KLKQIEKEY--------TQKLAKSSQ 819
            +  +K  +E+K+   A  E  LE++ +       +LK ++K Y         +++ +SS 
Sbjct: 962  STLKK-SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1020

Query: 820  IIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRS 879
             I+          +E +++ L  + RL +V     +     ++   QA+K    +LE ++
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIEV-----ERNNATLQAEKQALKTQLKQLETQN 1075

Query: 880  NQVRCAEKKLQHKELESQEQITYIRQE 906
            N ++     LQ + +  QEQ T ++ +
Sbjct: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQ 1102



 Score =  102 bits (254), Expect = 2e-21
 Identities = 168/740 (22%), Positives = 318/740 (42%), Gaps = 133/740 (17%)

Query: 317 KKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHN----------AVAEM 366
           KK+  L+  C V  + KE+ I  ++ +   +  ++    ++  HN           V +M
Sbjct: 122 KKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDM 181

Query: 367 EQEK---------------FDLQKQHTENIQELLED----------TNVRLNKMESEYMA 401
            QE                 D + +H+E I EL E+          ++   +   S  M 
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241

Query: 402 QTQSTNHMIKEL---EARVQQLTGEAENSNLQ----RQKLIQEKAELERCYQITCSELQE 454
           +T+S  H+  EL   +A++++L  E E    Q    +Q+L Q + EL+R  Q   + L +
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 455 VKARRN----------------------TLHKEKDHLVNDY--------EQNMKLLQTKY 484
            ++ R                       + +KE+ H +  Y        E N  LL+TK 
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK- 360

Query: 485 DADINLLKQEHALSASKA-SSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKS 543
                    E  L  ++A S  + ELE+   QLK +L + E++R    +  E    ME++
Sbjct: 361 ------TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE--LMEEN 412

Query: 544 HLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAAL 603
               + +K++ D    L    E   +     E   K    ++  +T  + L+ +  + +L
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 604 ----EEFKR---QVELNSEKVYAEMKE-QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQ 655
               EE +     VE N+ K+    KE Q    + ++  ++ ++EKQS +    L     
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532

Query: 656 RYEQQI---VELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQI 712
           + + Q+   +E   E+ + +  +L+Q N   +  V    R+   +  + R  ++E EN+I
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTV-SSLRQRSQISAEARVKDIEKENKI 591

Query: 713 -QEFKKRDAQVIADMEAQVHKLREEL--INVNSQRKQQLV-ELGLLREEEK--QRATREH 766
             E  K  +  ++ +E +  ++++EL       +R ++L  EL  L +E +  Q+     
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651

Query: 767 EIVVNKLKA------ESEKMKIELKKTHAAETEMT-----LEKANSKLKQIEKEY---TQ 812
           +I   K++A      E E+   +LKKT  +   +T     LEK NS+L +   E     +
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711

Query: 813 KLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKV-- 870
            L  +S  +A+LQ     L+ E  Q     ++ L+ ++  F  +K + +  + Q + +  
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQ----LKKGLELLKASF--KKTERLEVSYQGLDIEN 765

Query: 871 --LQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLR-QELEDTI 927
             LQ  LEN + +++  E +LQ  E+E+        Q  +  L+ L  +S R ++LE   
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMEN--------QTLQKNLEELKISSKRLEQLEKEN 817

Query: 928 SSLKSQVNFLQKRASILQEE 947
            SL+ + + L+K    L++E
Sbjct: 818 KSLEQETSQLEKDKKQLEKE 837



 Score =  101 bits (251), Expect = 4e-21
 Identities = 158/784 (20%), Positives = 346/784 (44%), Gaps = 120/784 (15%)

Query: 255  KELDMKTKMMEAKFHEEKLKLQQ---------KHDADVQKILE--RKNNEIEELKTLYRS 303
            + L  K +++E +  +EK  LQ          K  A ++K +E  R+N+E  ++K L + 
Sbjct: 501  QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE-RQIKILEQE 559

Query: 304  KQH--ETEETIRK-----LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWE 356
             +H  +T  ++R+      E +V+ + ++ +++ E+ ++  ++L KI E     +  + E
Sbjct: 560  NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI-EFEKRQIKKELE 618

Query: 357  --KKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMES--EYMAQTQSTNHMIKE 412
              K+      E+E E   L+K++ E +Q+ + +  +   K+E+  +  ++ +  N  +K+
Sbjct: 619  HYKEKGERAEELENELHHLEKEN-ELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677

Query: 413  LEARVQQLTGEAENSNLQRQKLIQEKAELER------CYQITCSELQ----EVKARRNTL 462
                 + LT + E+   +  +L +E  EL R      C  +  ++LQ    E+++ +  L
Sbjct: 678  TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737

Query: 463  HKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSAS-----KASSMIEELEQNVCQLK 517
             K  + L   +++  +L  +    DI   + +  L  S     +  S +++LE     L+
Sbjct: 738  KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797

Query: 518  QQLQESELQRKQ-QLRDQENKF------QMEKSHLKHIYEKKAHDLQSEL-DKGKEDTQK 569
            + L+E ++  K+ +  ++ENK       Q+EK   +   E K    Q+E+ D   E+   
Sbjct: 798  KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857

Query: 570  KIHKFEEALK--EKE-----EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMK 622
            KI   E+  K   KE     E   R+ E+++   +    A  + K  V L  + V  ++K
Sbjct: 858  KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917

Query: 623  EQ-----MEKVEADL-----TRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK 672
             Q     +EK+  +L      + + L ++QS +  ++L + +    +  ++  LE ++EK
Sbjct: 918  TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL---ESTLKKSLEIKEEK 974

Query: 673  THLLQQHNAEKDSLVRDHEREIENLEKQLRAANM--EHENQIQEFK---------KRDAQ 721
               L+    E  +  +   +E++ ++K   A     + E  +Q            +R++Q
Sbjct: 975  IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1034

Query: 722  VIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMK 781
               +   ++ K+++ LI V         E   L+ + KQ  T+ + +    L  + + + 
Sbjct: 1035 ---ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1091

Query: 782  IELKKTHAAETEMTLEKANSKLK----QIEKEYTQKLAKSSQII---------------- 821
            ++ + T       TL+  N+KL+     +  + T  + +++Q++                
Sbjct: 1092 LQEQNT-------TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144

Query: 822  -AELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSN 880
              +L++   SL +++ + +L  ER+  +        K   ++   + ++V   +LE+R N
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLI--SKHGTLKSAHKNLEVEHRDLEDRYN 1202

Query: 881  QVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQ------ELEDTISSLKSQV 934
            Q+   ++K Q ++LE   ++   +   E K    + A  ++       L  T S L  + 
Sbjct: 1203 QL--LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260

Query: 935  NFLQ 938
              LQ
Sbjct: 1261 EVLQ 1264



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 154/698 (22%), Positives = 302/698 (43%), Gaps = 109/698 (15%)

Query: 336 QIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQ------------- 382
           +I  L++  E+ TE        +L +   E+EQ + +L++   EN+              
Sbjct: 259 KIRRLRQELEEKTE--------QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310

Query: 383 --ELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAE 440
             + L +  VR++K+ESE +++ +   H I+  +ARV++L  E     L+ + +++++ E
Sbjct: 311 ELDALREKAVRVDKLESE-VSRYKERLHDIEFYKARVEELK-EDNQVLLETKTMLEDQLE 368

Query: 441 LERCYQITCSELQ----EVKARRNTLHKEKD----HLVNDYEQNMKL-LQTKYDADINL- 490
             R       EL+    ++KA+ + +  E+D     +    E+NM L +  K   D +L 
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLH 428

Query: 491 -------LKQEHALSASKASSMIEELEQNVCQ--LKQQLQESELQRK-QQLR-------- 532
                  + +   LS +   S+  E+ +      LK +++   L +  ++LR        
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488

Query: 533 DQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQ 592
           +     +MEK + +    KK   L++E+ + K+  Q   +  ++ +KEK  QL +  E  
Sbjct: 489 NASKILKMEKENQR--LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK-AQLEKTIETL 545

Query: 593 RLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLED 652
           R  +++    LE+    +      +    +   E    D+ +   +  +  KE   +L  
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605

Query: 653 IRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHE-------------REIENLEK 699
           I   +E++ ++ +LEH +EK    ++   E   L +++E              +IE LE+
Sbjct: 606 I--EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663

Query: 700 ---QLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLRE 756
              +L   N + +  +  FK    Q +  +E +  +L EE  N+  +R  + ++   ++ 
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQ-LESLEKENSQLDEE--NLELRRNVESLKCASMKM 720

Query: 757 EEKQRATREHEIVVNKLKAESEKMKIELKKTHAAET------------EMTLEKANSKLK 804
            + Q   +E E    +LK   E +K   KKT   E             + TLE +N K++
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780

Query: 805 QIEKEYTQKLAKSSQIIAELQTTISSLKEENSQ-QQLAAERR-LQDVRQKFEDEKKQLIR 862
           Q+E E  Q L   +Q    LQ  +  LK  + + +QL  E + L+    + E +KKQL +
Sbjct: 781 QLESE-LQDLEMENQ---TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836

Query: 863 DND---QAIKVLQDELENRSNQVRCAEK--KLQHKELESQEQITYIRQEYETKLKGLMP- 916
           +N    Q  ++    LE  + ++   EK  K   KE+   ++     +E E + K L+  
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896

Query: 917 --------ASLRQELEDTISSLKSQVNFLQKRASILQE 946
                    +LR++L       +   N L+K    L++
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 110/520 (21%), Positives = 227/520 (43%), Gaps = 67/520 (12%)

Query: 252  IREKELDMKTKM-MEAKFHEEKLKLQQKHDADVQKILERKNNEIEEL---KTLYRSKQHE 307
            ++   +D+KT + +      EKLK QQ ++      LE+  +E+E++   K      +  
Sbjct: 894  VKRATIDIKTLVTLREDLVSEKLKTQQMNND-----LEKLTHELEKIGLNKERLLHDEQS 948

Query: 308  TEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQST---ESLNNDWE--KKLHNA 362
            T++  + LE K+++ ++      E KE++IA L+   E+ST   + L  + +  KK + A
Sbjct: 949  TDDRYKLLESKLESTLKKSL---EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1005

Query: 363  VAEMEQEKFDLQ-------------KQHTENIQELLE--DTNVRLNKMESEYMAQTQSTN 407
            + + + E+  +Q             ++  E  +ELL+  D  + + +  +   A+ Q+  
Sbjct: 1006 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1065

Query: 408  HMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKAR--RNTLHKE 465
              +K+LE          +N+NLQ Q L  ++  +    Q T  + Q  K +   +TL+ +
Sbjct: 1066 TQLKQLET---------QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116

Query: 466  KDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESEL 525
               L+N   Q              LL Q+ +L  ++  S+I+E E         +++ E 
Sbjct: 1117 STSLMNQNAQ--------------LLIQQSSLE-NENESVIKEREDLKSLYDSLIKDHE- 1160

Query: 526  QRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQL 585
              K +L  +    + E    KH   K AH       +  ED   ++ K +  L++ E+ L
Sbjct: 1161 --KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1218

Query: 586  TRVTEVQRLQAQQADAALEEFKRQVELNS--EKVYAEMKEQMEKVEADLTRSKSLREKQS 643
                E   L+ +  +    E+K+    N      Y+++ ++ E ++ D    KSL     
Sbjct: 1219 KVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK 1278

Query: 644  KE---FLWQLEDIRQRYEQ-QIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEK 699
             E      +   ++++Y+Q  I   KL ++ E    L+ +  E++  + D  + +    +
Sbjct: 1279 LEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNR 1338

Query: 700  QLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELIN 739
             L   NME ++     +++    + ++  Q  KL E++++
Sbjct: 1339 TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 152/719 (21%), Positives = 298/719 (41%), Gaps = 134/719 (18%)

Query: 345 EQSTESLNNDWEKKLHNAVAEMEQEKFDLQ-----------------------KQHTENI 381
           ++  + +NND   ++HN    + Q KF  Q                       +Q TE +
Sbjct: 62  QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEV 121

Query: 382 QE---LLEDTNVRLNKMESEYMAQTQSTNHMIK-ELEARVQQLTGEAEN-SNLQRQKLI- 435
           ++   LL    V+  K E E++ + Q  +   K  + A +Q++T   EN  +LQ  ++  
Sbjct: 122 KKLLLLLLGCAVQCQKKE-EFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180

Query: 436 QEKAELERCYQITCSELQEVKARRN-------TLHKEKDHL------------------- 469
             + ++E   +     L+ +   R+        L +E+D L                   
Sbjct: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240

Query: 470 -VNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE-----S 523
              +  Q++ +      A I  L+QE      +     +ELEQ   +LK+  QE     S
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300

Query: 524 ELQRKQQLRDQENKFQMEKSHLKHI------YEKKAHDLQ---SELDKGKEDTQKKIH-- 572
           + +  +  RD+ +  + +   +  +      Y+++ HD++   + +++ KED Q  +   
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360

Query: 573 -KFEEALKEKEEQLTRVTEVQR----LQAQQADAALE---EFKRQVELNSEKVYAEMKEQ 624
              E+ L+    +  ++ E+++    L+A+  D  +E   + K+  EL  E +  EM ++
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420

Query: 625 MEKVEA--------DLTRSKSLREKQSKEF-----------LWQLEDIRQRYEQQIVELK 665
               E+         ++R+  L E   K             L +LE   Q   + + EL+
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480

Query: 666 -------------LEHEQEKTHLLQQHNAEKDSLVRDHE--REIENLEKQLRAANMEHEN 710
                        L+ E+E   L ++    ++ +V++ +  +  +NL K L     + E 
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540

Query: 711 QIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATRE--HEI 768
            I+  ++   + I  +E +   L + + ++  QR Q   E  +   E++ +   E   E 
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKENKILHESIKET 599

Query: 769 VVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEK--EYTQKLAKSSQIIAELQT 826
                K E EK +I+ +  H  E     E+  ++L  +EK  E  QK   + +I  E   
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCE--- 656

Query: 827 TISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSN--QVRC 884
            I +L++ENS+ +    R+L+     F++   QL     +  ++ ++ LE R N   ++C
Sbjct: 657 KIEALEQENSELE-RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715

Query: 885 AEKKLQHKELESQEQITYIRQEYETKLKG--LMPASLR--QELEDTISSLKSQVNFLQK 939
           A  K+   +LE++E    +  E E   KG  L+ AS +  + LE +   L  +   LQK
Sbjct: 716 ASMKMAQLQLENKE----LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  123 bits (308), Expect = 9e-28
 Identities = 182/900 (20%), Positives = 374/900 (41%), Gaps = 132/900 (14%)

Query: 126  ELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLSPTHRE---DGQN 182
            +++  E  L +  K     +N +     ++   ++   KL     +L   H++   D Q 
Sbjct: 953  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012

Query: 183  ITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSS 242
               K+  +   K  +     D+E  L             ++K + + L   K  L     
Sbjct: 1013 EEDKVNTLTKAKVKLEQQVDDLEGSLE------------QEKKVRMDLERAKRKLEGDLK 1060

Query: 243  FHDDHFLSRIREKE-LD--MKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKT 299
               +  +    +K+ LD  +K K  E      +++ +Q   + +QK L+     IEEL+ 
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE- 1119

Query: 300  LYRSKQHETEETIR-KLEKKVQTLIRDCQVIRETKED-------QIAELKKICEQSTESL 351
                ++ E E T R K+EK    L R+ + I E  E+       QI E+ K  E   + +
Sbjct: 1120 ----EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI-EMNKKREAEFQKM 1174

Query: 352  NNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIK 411
              D E+    A  + E     L+K+H +++ EL E               Q  +   + +
Sbjct: 1175 RRDLEE----ATLQHEATAAALRKKHADSVAELGE---------------QIDNLQRVKQ 1215

Query: 412  ELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVN 471
            +LE    +   E ++     +++I+ KA LE+     C  L++      +  +E    VN
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM----CRTLEDQMNEHRSKAEETQRSVN 1271

Query: 472  DYEQNMKLLQTKYDADINLLKQEHALSAS----------KASSMIEELEQNV-------- 513
            D       LQT+       L ++ AL +           +   +  +LE+ V        
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331

Query: 514  --------CQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKE 565
                    C L ++  E E + K +L+   +K   E +  +  YE  A     EL++ K+
Sbjct: 1332 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK 1391

Query: 566  DTQKKIHKFEEA----------LKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSE 615
               +++ + EEA          L++ + +L    E   +  ++++AA     ++ + N +
Sbjct: 1392 KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK-QRNFD 1450

Query: 616  KVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL 675
            K+ AE K++ E+ +++L  S    +K+++    +L  ++  YE+ +  L+   ++E  +L
Sbjct: 1451 KILAEWKQKYEESQSELESS----QKEARSLSTELFKLKNAYEESLEHLE-TFKRENKNL 1505

Query: 676  LQQHNAEKDSLVRDHE--REIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKL 733
             ++ +   + L    +   E+E + KQL A  ME ++ ++E +      +   E ++ + 
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS----LEHEEGKILRA 1561

Query: 734  REELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKL--------KAESEKMKIELK 785
            + E   + ++ +++L E    ++EE ++A R H  VV+ L        ++ +E ++++ K
Sbjct: 1562 QLEFNQIKAEIERKLAE----KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 1617

Query: 786  -KTHAAETEMTLEKANSKLKQIEKEY--TQKLAKSSQIIA--------ELQTTISSLKEE 834
             +    E E+ L  AN    + +K+    Q L K +QI          +L+  I+ ++  
Sbjct: 1618 MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERR 1677

Query: 835  NSQQQLAAERRLQDVRQKFEDEK--KQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHK 892
            N+  Q   E     V Q     K  +Q + +  + +++L  +  +  NQ +  +  L   
Sbjct: 1678 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737

Query: 893  ELESQEQITYIRQEYETKLKGLMPASLRQE----LEDTISSLKSQVNFLQKRASILQEEL 948
            + E +E +   R   E   K +  A++  E     +DT + L+     +++    LQ  L
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1797



 Score =  117 bits (294), Expect = 4e-26
 Identities = 146/692 (21%), Positives = 316/692 (45%), Gaps = 96/692 (13%)

Query: 271  EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKV----------Q 320
            ++ KLQ ++  ++ + L+ K   I +L     +   + E+  R+LE++V          Q
Sbjct: 1276 QRAKLQTEN-GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQ 1334

Query: 321  TLIRDCQVIRETKEDQI---AELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQH 377
            +   DC ++RE  E++    AEL+++  ++   +   W  K      +  +E  + +K+ 
Sbjct: 1335 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ-WRTKYETDAIQRTEELEEAKKKL 1393

Query: 378  TENIQEL---LEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKL 434
             + +QE    +E  N + + +E         T H    L+  ++ L  + E SN     L
Sbjct: 1394 AQRLQEAEEAVEAVNAKCSSLEK--------TKH---RLQNEIEDLMVDVERSNAAAAAL 1442

Query: 435  IQEK-------AELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDAD 487
             +++       AE ++ Y+ + SEL+  +    +L  E   L N YE++++ L+T    +
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502

Query: 488  INLLKQEHALSASKASS--MIEELEQNVCQL---KQQLQESELQRKQQLRDQENKF---Q 539
             NL ++   L+    SS   I ELE+   QL   K +LQ +  + +  L  +E K    Q
Sbjct: 1503 KNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQ 1562

Query: 540  MEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQA 599
            +E + +K   E+K  +   E+++ K +  + +   + +L  +         V++    + 
Sbjct: 1563 LEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKK----KM 1618

Query: 600  DAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQ 659
            +  L E + Q+  ++ ++ AE ++Q++ +++ L           K+   QL+D  +  + 
Sbjct: 1619 EGDLNEMEIQLS-HANRMAAEAQKQVKSLQSLL-----------KDTQIQLDDAVRANDD 1666

Query: 660  QIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQL-------RAANMEHENQI 712
              ++  +   + + +LLQ    E  ++V   ER  +  E++L       +  + ++ + I
Sbjct: 1667 --LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724

Query: 713  QEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNK 772
             + KK DA  ++ ++ +V +  +E  N   + K+ + +  ++ EE K+            
Sbjct: 1725 NQKKKMDAD-LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE---------QD 1774

Query: 773  LKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK 832
              A  E+MK  +++T   + +  L++A     +  K+  QKL      + EL+  + + +
Sbjct: 1775 TSAHLERMKKNMEQT-IKDLQHRLDEAEQIALKGGKKQLQKLEAR---VRELENELEAEQ 1830

Query: 833  EENSQQ---QLAAERRLQDVRQKFEDEKKQLIRDND---------QAIKVLQDELENRSN 880
            + N++       +ERR++++  + E+++K L+R  D         +A K   +E E ++N
Sbjct: 1831 KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1890

Query: 881  QVRCAEKKLQHKELESQEQITYIRQEYETKLK 912
                  +K+QH EL+  E+   I +    KL+
Sbjct: 1891 TNLSKFRKVQH-ELDEAEERADIAESQVNKLR 1921



 Score =  103 bits (256), Expect = 1e-21
 Identities = 155/671 (23%), Positives = 303/671 (45%), Gaps = 115/671 (17%)

Query: 216  ENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKM---MEAKFHEEK 272
            E  R L +K   +S +T +  L  +    D   L R  E+E+  K  +   +++  H+  
Sbjct: 1286 ELSRQLDEKEALISQLT-RGKLTYTQQLED---LKRQLEEEVKAKNALAHALQSARHDCD 1341

Query: 273  LKLQQKHD-----ADVQKILERKNNEIEELKTLYRS----KQHETEETIRKL-------E 316
            L  +Q  +     A++Q++L + N+E+ + +T Y +    +  E EE  +KL       E
Sbjct: 1342 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1401

Query: 317  KKVQTLIRDCQVIRETK---EDQIAELKKICEQST-------------ESLNNDWEKKLH 360
            + V+ +   C  + +TK   +++I +L    E+S              + +  +W++K  
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461

Query: 361  NAVAEMEQ----------EKFDLQKQHTENIQEL--LEDTNVRLNKMESEYMAQTQSTNH 408
             + +E+E           E F L+  + E+++ L   +  N  L +  S+   Q  S+  
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGK 1521

Query: 409  MIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCY-QITCSELQ--EVKARRNTLHKE 465
             I ELE   +QL  EAE   LQ   L + +A LE    +I  ++L+  ++KA       E
Sbjct: 1522 TIHELEKVRKQL--EAEKMELQ-SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1578

Query: 466  KDHLVNDYEQN----MKLLQTKYDADINLLKQ-------------EHALSASKASSMIEE 508
            KD  +   ++N    +  LQT  DA+     +             E  +  S A+ M  E
Sbjct: 1579 KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAE 1638

Query: 509  LEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQ 568
             ++ V  L+  L+++++Q    +R  ++     K ++  I E++ + LQ+EL    E+ +
Sbjct: 1639 AQKQVKSLQSLLKDTQIQLDDAVRANDDL----KENIA-IVERRNNLLQAEL----EELR 1689

Query: 569  KKIHKFEEALKEKEEQLTRVTE-VQRLQAQQADAALEEFKRQVELNS-----EKVYAEMK 622
              + + E + K  E++L   +E VQ L +Q      ++ K   +L+      E+   E +
Sbjct: 1690 AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR 1749

Query: 623  EQMEKVEADLTRSKSLREKQSKE--FLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHN 680
               EK +  +T +  + E+  KE      LE +++  EQ I +L+        H L +  
Sbjct: 1750 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ--------HRLDE-- 1799

Query: 681  AEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINV 740
            AE+ +L +  +++++ LE ++R    E EN+++  +KR+A+ +  M     +++E     
Sbjct: 1800 AEQIAL-KGGKKQLQKLEARVR----ELENELEAEQKRNAESVKGMRKSERRIKELTYQT 1854

Query: 741  NSQRK-----QQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIEL----KKTHAAE 791
               RK     Q LV+   L+ +  +R   E E   N   ++  K++ EL    ++   AE
Sbjct: 1855 EEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1914

Query: 792  TEMTLEKANSK 802
            +++   +A S+
Sbjct: 1915 SQVNKLRAKSR 1925



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 148/668 (22%), Positives = 283/668 (42%), Gaps = 106/668 (15%)

Query: 314  KLEKKVQTLIRDCQVIRE--TKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKF 371
            KL  K++ L++  +  +E  + +++   LK+  E+S         K+L   +  + QEK 
Sbjct: 831  KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEAR-----RKELEEKMVSLLQEKN 885

Query: 372  DLQKQHTENIQELLEDTNVR---LNKMESEYMAQTQSTNHMIKELEARVQQLTG-----E 423
            DLQ Q  +  Q+ L D   R   L K + +  A+ +  N  +++ E    +LT      E
Sbjct: 886  DLQLQ-VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 944

Query: 424  AENSNLQRQ---------KLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYE 474
             E S L+R          K+ +EK   E   +    E+  +      L KEK  L   ++
Sbjct: 945  DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004

Query: 475  QNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQ 534
            Q +  LQ + D    L K +             +LEQ V  L+  L            +Q
Sbjct: 1005 QALDDLQAEEDKVNTLTKAK------------VKLEQQVDDLEGSL------------EQ 1040

Query: 535  ENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRL 594
            E K +M+    K   E      Q  +   + D Q    + +E LK+K+ +L  +    R+
Sbjct: 1041 EKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQ----QLDERLKKKDFELNALN--ARI 1094

Query: 595  QAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIR 654
            + +QA         Q++   +++ A ++E  E++EA+ T +++  EK   +   +LE+I 
Sbjct: 1095 EDEQA------LGSQLQKKLKELQARIEELEEELEAERT-ARAKVEKLRSDLSRELEEIS 1147

Query: 655  QRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQE 714
            +R E+      ++ E  K                  E E + + + L  A ++HE     
Sbjct: 1148 ERLEEAGGATSVQIEMNK----------------KREAEFQKMRRDLEEATLQHEATAAA 1191

Query: 715  FKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLK 774
             +K+ A  +A++  Q+  L+     +  ++ +  +EL  +    +Q         + K K
Sbjct: 1192 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ---------IIKAK 1242

Query: 775  AESEKMKIELK---KTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSL 831
            A  EKM   L+     H ++ E T    N    Q  K  T+   + S+ + E +  IS L
Sbjct: 1243 ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN-GELSRQLDEKEALISQL 1301

Query: 832  KEENSQQQLAAERRLQDVRQKFEDE--KKQLIRDNDQAIKVLQDELENRSNQVRCAEKKL 889
                ++ +L   ++L+D++++ E+E   K  +    Q+ +   D L  +  +   A+ +L
Sbjct: 1302 ----TRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1357

Query: 890  QHKELESQEQITYIRQEYET----KLKGLMPASLR-----QELEDTISSLKSQVNFLQKR 940
            Q    ++  ++   R +YET    + + L  A  +     QE E+ + ++ ++ + L+K 
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417

Query: 941  ASILQEEL 948
               LQ E+
Sbjct: 1418 KHRLQNEI 1425



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 85/368 (23%), Positives = 158/368 (42%), Gaps = 30/368 (8%)

Query: 594  LQAQQADAALEEFKRQVELNSEKVYAEM--KEQMEKVEADLTRSKSLREKQS-KEFLWQL 650
            L  +  D  L     +++  S  V A M  K+ +E+ ++ L    ++R     K + W  
Sbjct: 772  LLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW-- 829

Query: 651  EDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHEN 710
              ++  ++ + +    E E+E   + ++    K++L +   R  E  EK +     +++ 
Sbjct: 830  --MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDL 887

Query: 711  QIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVV 770
            Q+Q   ++D   +AD E +  +L +  I + ++ K+    L    +EE+  A    E+  
Sbjct: 888  QLQVQAEQDN--LADAEERCDQLIKNKIQLEAKVKEMNERL---EDEEEMNA----ELTA 938

Query: 771  NKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIE---KEYTQKLAKSSQIIAELQTT 827
             K K E E  ++   K    + E+TL K   +    E   K  T+++A   +IIA+L   
Sbjct: 939  KKRKLEDECSEL---KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995

Query: 828  ISSLKEENSQ--QQLAAE----RRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQ 881
              +L+E + Q    L AE      L   + K E +   L    +Q  KV  D LE    +
Sbjct: 996  KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD-LERAKRK 1054

Query: 882  VRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTI-SSLKSQVNFLQKR 940
            +    K  Q   ++ +     + +  + K   L   + R E E  + S L+ ++  LQ R
Sbjct: 1055 LEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQAR 1114

Query: 941  ASILQEEL 948
               L+EEL
Sbjct: 1115 IEELEEEL 1122


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  122 bits (307), Expect = 1e-27
 Identities = 130/628 (20%), Positives = 292/628 (46%), Gaps = 67/628 (10%)

Query: 249 LSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHET 308
           LS +  ++      + E     + L L+   +    + L+ KN +++E   L  S++ E 
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240

Query: 309 EETIRKLEKKVQT--LIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEM 366
           +  +++L++K++   L+   Q ++   +    EL+ +  +    +    E +L N + + 
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE---ENELWNRLNQQ 297

Query: 367 EQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAEN 426
           ++EK   Q++  +  +E +++   ++ + E +   Q        +E   R +++  E E 
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ--------EEKMRRQEEMMWEKEE 349

Query: 427 SNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDA 486
              ++++++ EK E  R  +    E +E   R+  +  EK+  + + E+ M         
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH-------- 401

Query: 487 DINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQ-LRDQENKFQMEKSHL 545
                +QE      +     E++ +   Q K+Q QE+++ R+++ +R+QE K + ++  +
Sbjct: 402 -----EQEKIREQEEKRQEEEKIRE---QEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 453

Query: 546 KHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
               E+K H+ +   ++ K   Q+++ + EE + E+EE + R  E    Q ++     E+
Sbjct: 454 WR-QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEE-IWRQKEKMHEQEEKIRKQEEK 511

Query: 606 FKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK 665
             RQ E        +++EQ EK+            ++ +E +W+ E+  +  E+   E +
Sbjct: 512 VWRQEE--------KIREQEEKI------------REQEEKMWRQEEKIREQEEMWREEE 551

Query: 666 LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIAD 725
             HEQEK    ++   ++D + R  E+  E  EK  R      E +I+E +++  +    
Sbjct: 552 KMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR-----QEEKIREQEEKRQEQEEK 606

Query: 726 MEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELK 785
           M  Q  K+RE+   +  Q ++   +   +RE+E+   T+E E    K+  + EKM  + +
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEM--TQEQE---EKMGEQEEKMCEQEE 661

Query: 786 KTHAAETEMTLEKANSKLKQIEK---EYTQKLAKSSQIIAELQTTISSLKEENSQQQLAA 842
           K    E E T+ +   K+++ EK   E  +K+ +  +++ E +  +   +E+  +Q+   
Sbjct: 662 KMQ--EQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 719

Query: 843 ERRLQDVRQKFEDEKKQLIRDNDQAIKV 870
           + + + +R++ E   +Q +R   Q  K+
Sbjct: 720 QEQEEKMRRQEEKMWEQEVRLRQQEEKM 747



 Score =  112 bits (279), Expect = 2e-24
 Identities = 130/608 (21%), Positives = 297/608 (48%), Gaps = 44/608 (7%)

Query: 327 QVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLE 386
           + +R   E Q+  ++ +  Q TE     +  +  +AV ++E E  DL  +  ++ +   E
Sbjct: 119 EALRRELEAQVHTIRILTCQKTELQMALYYSQ--HAVKQLEGEARDLISRLHDSWKFAGE 176

Query: 387 DTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQ 446
                L +  S    Q +  +  I+EL      L+ E   + +  ++L ++ A+L+   Q
Sbjct: 177 -----LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ 231

Query: 447 ITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMI 506
           +  SE  E++     L ++ +         + L Q +  A+ + L +E    ++K  + +
Sbjct: 232 LVESEKSEIQLNVKELKRKLERA------KLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285

Query: 507 EELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKE- 565
           EE E    +L QQ +E   ++++++++ E K Q ++  ++   E+K  + + ++ + +E 
Sbjct: 286 EENEL-WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE-QEEKIREQEEKMRRQEEM 343

Query: 566 --DTQKKIHKFEEALKEKEEQLTRVTEV---QRLQAQQADAALEEFKRQVELNSEKVYAE 620
             + ++K+ + EE + EKEE++ R  E+   +  + ++ +  + E + ++    EK++ +
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 403

Query: 621 MK--EQMEK-VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQ-QIVELKLEHEQEKTH-- 674
            K  EQ EK  E +  R +  R++Q  +   Q E IR++ E+ +  E K+  ++EK H  
Sbjct: 404 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 463

Query: 675 --LLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEA---Q 729
             + ++   ++   +   E +I   E+  R     HE + ++ +K++ +V    E    Q
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQE-EKIRKQEEKVWRQEEKIREQ 522

Query: 730 VHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHA 789
             K+RE+   +  Q ++   +  + REEEK     E E +  + K + ++ K+  ++   
Sbjct: 523 EEKIREQEEKMWRQEEKIREQEEMWREEEKM---HEQEKIWEEEKRQEQEDKMWRQEEKI 579

Query: 790 AETEMTLEKANSKLKQIE---KEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRL 846
            E E  + +   K+++ E   +E  +K+ K  + I E +  I   +EE  ++Q    R  
Sbjct: 580 REQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE-QEEKIREQEEKIREQ 638

Query: 847 QDVRQKFED---EKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYI 903
           +++ Q+ E+   E+++ + + ++ ++  ++ +  +  ++R  EKK++ +E + +EQ   +
Sbjct: 639 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQ-EEM 697

Query: 904 RQEYETKL 911
            QE E K+
Sbjct: 698 MQEQEEKM 705



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 113/608 (18%), Positives = 274/608 (45%), Gaps = 57/608 (9%)

Query: 125 GELETSEHKLNESWKLSSGEDNTLVQSPTDVYSREQYTGKLRVRSHSLS----------P 174
           GE      +L++SWK +   +  L    T     ++Y  +L     +LS           
Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 217

Query: 175 THREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPK 234
             +E    +  K+  V S+KS + L+  +++ +L    L +   + L+ +   +      
Sbjct: 218 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ-LQAEADHLGKELQS 276

Query: 235 FSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEI 294
            S +  +   ++   +R+ +++ + K    E K  E + K+Q++ +   ++  E K  E 
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQ-EEKMWRQEEKIQEWEEKIQEQEEKIREQ--EEKIREQ 333

Query: 295 EELKTLYRSKQHETEETIRKLEK----KVQTLIRDCQVIRETKEDQIAELKKICEQSTES 350
           EE          E EE +R+ E+    K + + R  +++ E KE+++   +++  +  E 
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE-KEEKMRRQEEMMWEKEEK 392

Query: 351 LNNDWEKKLHNAVAEMEQEKFDLQKQHTENI--QELLEDTNVRLNKMESEYMAQTQSTNH 408
           +  + E+K+H      EQE+   ++Q  E I  QE  ++   ++ + E +   Q +    
Sbjct: 393 IR-ELEEKMHEQEKIREQEE---KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 448

Query: 409 MIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDH 468
             K++  + +++    E   ++ ++  QE+ E+ R  +    E +E+  ++  +H++++ 
Sbjct: 449 QEKKMWRQEEKIH---EQEKIREEEKRQEQEEMWR-QEEKIHEQEEIWRQKEKMHEQEEK 504

Query: 469 LVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRK 528
           +    E+  +  +   + +  + +QE  +   +    I E E+   + ++  ++ ++  +
Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMW--RQEEKIREQEEMWREEEKMHEQEKIWEE 562

Query: 529 QQLRDQENKFQMEKSHLKHIYEK--KAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLT 586
           ++ ++QE+K   ++  ++   EK  +  +   E ++ +++ ++K+ K EE ++E+EE++ 
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622

Query: 587 RVTEVQRLQAQQADAALEEFKRQVEL--NSEKVYAEMKEQMEKVEADLTRS--------K 636
              E  R Q ++     E  + Q E     E+   E +E+M++ E  + R         K
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682

Query: 637 SLREKQSK------------EFLWQLED--IRQRYEQQIVELKLEHEQEKTHLLQQHNAE 682
            +RE++ K            E +W+ E+    Q  + Q  E K+  ++EK    +    +
Sbjct: 683 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 742

Query: 683 KDSLVRDH 690
           ++  +++H
Sbjct: 743 QEEKMQEH 750



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 138/640 (21%), Positives = 283/640 (44%), Gaps = 106/640 (16%)

Query: 330 RETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTN 389
           +ET++ ++AE K   EQ T     D   + + +V        D +K+   N       T+
Sbjct: 53  KETRQSKLAEAK---EQLT-----DHHPQTNPSVGTAAS---DTKKKKINNGTNPETTTS 101

Query: 390 VRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 449
              +  E E  A  Q    + +ELEA+V  +           + L  +K EL+     + 
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTI-----------RILTCQKTELQMALYYSQ 150

Query: 450 SELQEVKAR-RNTLHKEKDH--LVNDYEQNMKLLQT---KYDADIN-LLKQEHALSASKA 502
             +++++   R+ + +  D      + EQ +  + T   K D  I  L K+  ALS    
Sbjct: 151 HAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELY 210

Query: 503 SSMI--EELEQNVCQLKQQLQESELQRKQ-QLRDQENKFQMEKSHLKHIYEKKAHDLQSE 559
            + I  EEL++   +L+++LQ  E ++ + QL  +E K ++E++ L    ++    LQ+E
Sbjct: 211 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ----LQAE 266

Query: 560 LDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYA 619
            D   ++ Q    K +  ++E E          RL  QQ     E+  RQ E        
Sbjct: 267 ADHLGKELQSVSAKLQAQVEENELW-------NRLNQQQE----EKMWRQEE-------- 307

Query: 620 EMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQH 679
           +++E  EK++                   Q E IR++ E      K+  ++EK    ++ 
Sbjct: 308 KIQEWEEKIQE------------------QEEKIREQEE------KIREQEEKMRRQEEM 343

Query: 680 NAEKDSLVRDHEREI-ENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELI 738
             EK+  +R  E  + E  EK  R   M  E   +E  +R  +++ + E ++ +L E++ 
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKIRELEEKM- 400

Query: 739 NVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEK 798
             + Q K        +RE+E++R  +E E +  + K + ++ K+  ++    E E  + +
Sbjct: 401 --HEQEK--------IREQEEKR--QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 448

Query: 799 ANSKL-KQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFE-DE 856
              K+ +Q EK + Q+  +  +   E        +EE  +Q+     + +  RQK +  E
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQE--------QEEMWRQEEKIHEQEEIWRQKEKMHE 500

Query: 857 KKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYET-KLKGLM 915
           +++ IR  ++ +   ++++  +  ++R  E+K+  +E + +EQ    R+E +  + + + 
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560

Query: 916 PASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGRR 955
               RQE ED +   + ++   +++    +E++   + +R
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKR 600


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/727 (23%), Positives = 315/727 (43%), Gaps = 129/727 (17%)

Query: 246 DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNE-IEELKTLYRSK 304
           DH L   ++K+ D     M+  F +EK+K+   ++ +  K +E  N E I+E +T+    
Sbjct: 281 DHLLEDYQKKKEDFT---MQISFLQEKIKV---YEMEQDKKVENSNKEEIQEKETIIE-- 332

Query: 305 QHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVA 364
             E    I + EKK   L           +D++    K+  +  E +     +++ N   
Sbjct: 333 --ELNTKIIEEEKKTLEL-----------KDKLTTADKLLGELQEQIVQK-NQEIKNMKL 378

Query: 365 EMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEA 424
           E+   K   ++Q +E I++L+        +   +   +T     M +E + +++QL   A
Sbjct: 379 ELTNSK-QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQL--RA 435

Query: 425 ENSNLQRQKLIQEKAELERCYQITCSELQEVKARR-----NTLHKEKDHLVNDYEQNMKL 479
           E   +  Q+++Q K EL R +    ++++E+K R      N L    +  VN  E  +KL
Sbjct: 436 ELDEMYGQQIVQMKQELIRQHM---AQMEEMKTRHKGEMENALRSYSNITVN--EDQIKL 490

Query: 480 LQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE---------SELQR-KQ 529
           +    + ++N+  Q+      K    +  + +  C L++QL++          ++QR +Q
Sbjct: 491 MNVAIN-ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549

Query: 530 QLRDQENKFQMEKSHLKHIYEKKAHDLQS-------ELDKGKEDTQKKIHKFEEALKEKE 582
            + +QE+K       L  + + KA  + +       EL    E T  KI K E   KEK 
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI-KLEMLEKEKN 608

Query: 583 EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQ 642
             L R+ E Q       +A LE  + Q+  + E+  +++KE +E +E  +   K      
Sbjct: 609 AVLDRMAESQ-------EAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEKLK---- 656

Query: 643 SKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLR 702
                   +++   Y+QQI  L+ E  Q+    ++    EKD+L+    + I  + K   
Sbjct: 657 --------DNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKL-- 702

Query: 703 AANMEHENQIQEFKKRDAQVIADMEAQVHKLREEL-INVNSQRKQQLVELGLLREEEKQR 761
                          +D Q     ++ V+   EE+ + +N  +K    E+ +LR+EEK++
Sbjct: 703 ---------------KDLQ-----QSLVNSKSEEMTLQINELQK----EIEILRQEEKEK 738

Query: 762 ATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQII 821
            T E E+   +LK E  + +++ K+    E    LE  NS LK  EK+  + + K    +
Sbjct: 739 GTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD-EKKTLEDMLKIHTPV 797

Query: 822 AELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQ 881
           ++ +  I     ++  +    E+ ++ + ++ ED K+Q I+        L +E+E + N 
Sbjct: 798 SQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ--------LNEEIEKQRNT 849

Query: 882 VRCAEKKLQHKELESQEQITYIRQ--------------EYETKLKGLMPASLRQELEDTI 927
              AEK  +    E QE+   + +              EY++KLK L      Q +  T 
Sbjct: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909

Query: 928 SSLKSQV 934
             +KS V
Sbjct: 910 VKMKSSV 916



 Score =  116 bits (291), Expect = 9e-26
 Identities = 160/773 (20%), Positives = 342/773 (44%), Gaps = 111/773 (14%)

Query: 252  IREKEL---DMKTKMMEAKFH----EEKLKLQQKHDADVQKILERKNNEIEELK---TLY 301
            I+EKE    ++ TK++E +      ++KL    K   ++Q+ + +KN EI+ +K   T  
Sbjct: 324  IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383

Query: 302  RSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHN 361
            + K+ ++ E I++L   V+ L +      + + D +  +++  ++  E L  + ++    
Sbjct: 384  KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQ 443

Query: 362  AVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLT 421
             + +M+QE   L +QH   ++E+       +      Y   T + +  IK +   + +L 
Sbjct: 444  QIVQMKQE---LIRQHMAQMEEMKTRHKGEMENALRSYSNITVNED-QIKLMNVAINELN 499

Query: 422  GEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQ 481
             + +++N Q++KL +E   +          L+E  A +  L    + L    EQ  +  Q
Sbjct: 500  IKLQDTNSQKEKLKEELGLI----------LEEKCALQRQLEDLVEELSFSREQIQRARQ 549

Query: 482  TKYDADINLLKQEHALS-ASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
            T       + +QE  L+ A K+ S +E+L+  +    +  +E EL+ + ++ + + K +M
Sbjct: 550  T-------IAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEE-QLTRVTEVQRLQ---- 595
             +     + ++ A   ++EL++ +  TQ      EE  K KE+ ++     +++L+    
Sbjct: 603  LEKEKNAVLDRMAESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660

Query: 596  ---AQQADAALEEFKRQVE-LNSEKVYAEMKE--------QMEKVEADLTRSKS------ 637
                QQ D    E  +++E +  EK     K+        +++ ++  L  SKS      
Sbjct: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720

Query: 638  LREKQSK-EFLWQLEDIRQRYEQQIVELKLEHE------QEKTHLLQQHNAE---KDSLV 687
            + E Q + E L Q E  +   EQ++ EL+L+ E      +EK + LQ+  A+   ++S++
Sbjct: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780

Query: 688  RDHEREIENLEK-QLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQ 746
            +D ++ +E++ K     +  E    +   K +    + + E ++      LI  N   KQ
Sbjct: 781  KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------LIEENEDLKQ 834

Query: 747  QLVELGLLREEEKQR-----ATREHEIVVNKLKAE--------------SEKMKIELK-K 786
            Q ++L    E EKQR     A +  E+   +L+ E                K ++E K K
Sbjct: 835  QCIQLN--EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSK 892

Query: 787  THAAETEMTLEKAN-------SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQ 839
              A   E+ L++ N       S +   +K +  +  +  +++ +  T +    E   +++
Sbjct: 893  LKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREK 952

Query: 840  LAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQ 899
            L   +RL D+ ++ + +  ++   N++ +K L+ E E  S + R  E  + H   E+   
Sbjct: 953  LELSQRLSDLSEQLKQKHGEISFLNEE-VKSLKQEKEQVSLRCRELEIIINHNRAENV-- 1009

Query: 900  ITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
                 Q  +T++  L+   +         S+        + + I+ E+  +++
Sbjct: 1010 -----QSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057



 Score =  105 bits (263), Expect = 2e-22
 Identities = 154/718 (21%), Positives = 309/718 (43%), Gaps = 134/718 (18%)

Query: 297 LKTLYRSK--QHETEETIRKLEKKVQTLIRDCQ--------VIRETKEDQIAELKKICEQ 346
           ++TL+  +   HE   ++ +LE ++ T   DC         V+R  K   +   ++    
Sbjct: 84  MRTLHSGEITSHEQGFSV-ELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVD 142

Query: 347 STESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQST 406
            + S     +   H    EM + +   ++   E +   LE+  V      +E + Q Q  
Sbjct: 143 DSYSEQGAQDSPTH---LEMMESELAGKQHEIEELNRELEEMRVTYG---TEGLQQLQEF 196

Query: 407 NHMIKELEARVQQLTGEAENSNLQRQKLIQEKAEL---ERCYQITCSELQEVKARRNTLH 463
              IK+ +  + QLT   + +  ++ + ++E  EL    +  QI   +LQ  +  RN+ H
Sbjct: 197 EAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTH 256

Query: 464 ---------------------KEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKA 502
                                +E+DHL+ DY++                K++  +  S  
Sbjct: 257 SSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK---------------KEDFTMQISFL 301

Query: 503 SSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSEL-- 560
              I+  E    +  +   + E+Q K+ + ++ N   +E+       EKK  +L+ +L  
Sbjct: 302 QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE-------EKKTLELKDKLTT 354

Query: 561 -DKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYA 619
            DK   + Q++I +  + +K  + +LT   + +R    Q+   +++    VE        
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKER----QSSEEIKQLMGTVE-------- 402

Query: 620 EMKEQMEKVEADLTRSKSLREKQSKEFLWQLE-DIRQRYEQQIVELKLEHEQEKTHLLQQ 678
           E++++  K     T      E++++  L QL  ++ + Y QQIV++K E       L++Q
Sbjct: 403 ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQE-------LIRQ 455

Query: 679 HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELI 738
           H A+ + +   H+ E+EN    LR+ +    N+ Q         I  M   +++L  +L 
Sbjct: 456 HMAQMEEMKTRHKGEMEN---ALRSYSNITVNEDQ---------IKLMNVAINELNIKLQ 503

Query: 739 NVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEK 798
           + NSQ+++   ELGL+  EEK    R+ E +V +L    E  +I+  +   AE E  L +
Sbjct: 504 DTNSQKEKLKEELGLIL-EEKCALQRQLEDLVEELSFSRE--QIQRARQTIAEQESKLNE 560

Query: 799 ANSKLKQIEKEYTQKLA-----KSSQIIAELQTTISSLKEE--NSQQQLAAERRLQDVRQ 851
           A+  L  +E    + ++     K  ++  E + T   +K E    ++    +R  +    
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620

Query: 852 KFEDEKKQLIRDNDQAIKVLQD--ELENRSNQVRCAEKKLQHKELESQEQITYIRQEYET 909
           + E  + QL+  +++ +  L++  E+E+R N     EK   +  +  ++QI  ++ E   
Sbjct: 621 ELERLRTQLLFSHEEELSKLKEDLEIEHRIN----IEKLKDNLGIHYKQQIDGLQNEMSQ 676

Query: 910 KLKG---------------LMPASLRQELEDTISSLKS-----QVNFLQKRASILQEE 947
           K++                ++  S  ++L+ ++ + KS     Q+N LQK   IL++E
Sbjct: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE 734



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 151/771 (19%), Positives = 342/771 (44%), Gaps = 89/771 (11%)

Query: 230  LMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKM-----MEAKFHEEKLKLQQKHDADVQ 284
            LM  K  ++  +    D    +++  E+D++ ++     +E + + E + L+Q++ A ++
Sbjct: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA-LE 2059

Query: 285  KILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKIC 344
            K LE+    ++E       ++   ++ I+KLE++++ + R  Q I E +  ++ +L    
Sbjct: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR-FQPISEHQTREVEQLANHL 2118

Query: 345  EQSTESLNNDW--EKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQ 402
            ++ T+  +     +++L   + E  +E   L+ +  E  Q LL   +      + ++   
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178

Query: 403  TQSTNHMIKELEARVQQLT---GEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARR 459
             ++   +  E++ + ++      E E +NL+ Q L Q + ELE   +    E+Q++  + 
Sbjct: 2179 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQ-LEQFREELENKNE----EVQQLHMQL 2233

Query: 460  NTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSAS-------KASSMIEELEQN 512
                KE    + + EQ  KL +   +     +K+  A+S         K + +I+E E  
Sbjct: 2234 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2293

Query: 513  VCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIH 572
            + QL +Q+ + + Q K      +NK   EK+ L    E +   L S+ +  K + +++I 
Sbjct: 2294 IDQLNEQVTKLQQQLKITT---DNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIE 2350

Query: 573  KFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADL 632
            +  E +++ +++L  + +   + A       +  K Q+++   +  A +++Q+E    ++
Sbjct: 2351 QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA-LEQQVETANEEM 2409

Query: 633  TRSKS-LREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQ-EKTHLLQQH--NAEKDSLVR 688
            T  K+ L+E   K           +  Q++  LK E E  EK   + ++  N   D L +
Sbjct: 2410 TFMKNVLKETNFK---------MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460

Query: 689  DHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQL 748
            D + E+E +  +    ++E++   + F++     I ++E ++ +L   +   + +  Q  
Sbjct: 2461 D-KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCY 2519

Query: 749  VELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEK 808
             ++  ++E+ +       + +VN  K   EK+                  A + + QI+ 
Sbjct: 2520 KQIKDMQEQGQFETEMLQKKIVNLQKIVEEKV------------------AAALVSQIQL 2561

Query: 809  EYTQKLAKSSQ----IIAELQTT----ISSLKEENSQQQLAA--------ERRLQDVRQK 852
            E  Q+ AK  Q    I +E + T    ++ L+E+     ++A        E ++ ++   
Sbjct: 2562 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS 2621

Query: 853  FEDEKKQL------IRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQE 906
               EK+Q+      + + ++ +  LQ  LE    + R  EKK   +++E  +  T +   
Sbjct: 2622 LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS 2681

Query: 907  YE-----TKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
             E      +L+ L   S+  + E  ++S K +   LQ+   + +  +T+ Q
Sbjct: 2682 NEESGFFNELEALRAESVATKAE--LASYKEKAEKLQEELLVKETNMTSLQ 2730



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 146/737 (19%), Positives = 331/737 (44%), Gaps = 69/737 (9%)

Query: 252  IREKEL-DMKTKMM-EAKFHEEKLKL-QQKHDADVQKILERKNNEIEELKTLYRS-KQHE 307
            + E++L DM+ +++ + + H++  +L +Q H   +++  E +    EE+K L R   Q  
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641

Query: 308  TEETIRKLEKKVQTLIRDCQVIRET----KEDQIAELKKICEQSTESLNNDWEKKLHN-A 362
            + +    + ++ + L+ + + +++     +E    EL+    Q+     N  E +     
Sbjct: 1642 SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK 1701

Query: 363  VAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTG 422
              E++++  D+  +   N +  L+  N RL K+  E +  T +    I      +   + 
Sbjct: 1702 EKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSS 1761

Query: 423  EAENSNLQRQKLI---QEKAELERCY-----QITCSELQEVKAR---RNTLHKEKDHLVN 471
            ++++S      LI   + +A ++ C      ++T   +         RN ++        
Sbjct: 1762 KSQSS----ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE 1817

Query: 472  DYEQNMKLLQTKY-DADINLLKQEHALS-ASKASSMIEELEQNVCQLKQQLQESELQRKQ 529
              E + +L+++ +   +I+   +E  L+ +S+  + +E+L + + +   QL+ +++ + +
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877

Query: 530  QLRDQENKFQMEKSHLK---------HIYEKKAHDLQSELDKGK---EDTQKKIHKFEEA 577
             +R+   + Q     LK         H   +    L  EL K +   +    +   FE  
Sbjct: 1878 LMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQ 1937

Query: 578  LKEKEEQLTRVTE---VQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
            ++EK + + R+ +       + Q+ +A  ++ + + EL S +  A MK +   VE  L +
Sbjct: 1938 IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA-MKAEAGPVEQQLLQ 1996

Query: 635  SKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREI 694
                  K+  E   Q E +R   ++Q+  L+++ E++ +  ++    EK++ + D  ++ 
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ-EKNTELMDLRQQN 2055

Query: 695  ENLEKQL-RAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL 753
            + LEKQL +      E  I    +RD       + ++ KL ++L  V   R Q + E   
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDV-----FQQEIQKLEQQLKVV--PRFQPISE--- 2105

Query: 754  LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIE---KEY 810
                     TRE E + N LK +++K    L      + +  +++ N +++++E   +E 
Sbjct: 2106 -------HQTREVEQLANHLKEKTDKCSELLLSKEQLQRD--IQERNEEIEKLEFRVREL 2156

Query: 811  TQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKV 870
             Q L  S+    +++          ++ +L+ E +LQ  R    D K++ I + ++ ++ 
Sbjct: 2157 EQALLVSADTFQKVEDR-KHFGAVEAKPELSLEVQLQAERDAI-DRKEKEITNLEEQLEQ 2214

Query: 871  LQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSL 930
             ++ELEN++ +V+    +L+ ++ ES  ++  + QE +     +    L  +  D +S+ 
Sbjct: 2215 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2274

Query: 931  KSQVNFLQKRASILQEE 947
               V F  K A I+QE+
Sbjct: 2275 DQHVLF-GKFAQIIQEK 2290



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 165/735 (22%), Positives = 325/735 (44%), Gaps = 102/735 (13%)

Query: 258  DMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEK 317
            ++  K+ +    +EKLK +     + +  L+R+  ++ E  +  R +     +TI + E 
Sbjct: 497  ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556

Query: 318  KVQTLIRDCQVIRETKEDQIA--------ELKKICEQSTESLNNDWEKKLHNAV------ 363
            K+    +    + + K + ++        ELK   E +   +  +  +K  NAV      
Sbjct: 557  KLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616

Query: 364  ---AEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQL 420
               AE+E+ +  L   H E + +L ED  +  +++  E +       H  ++++    ++
Sbjct: 617  SQEAELERLRTQLLFSHEEELSKLKEDLEIE-HRINIEKLKDNLGI-HYKQQIDGLQNEM 674

Query: 421  TGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLL 480
            + + E    ++  LI ++ +L     +  S+L+++          +  LVN   + M L 
Sbjct: 675  SQKIETMQFEKDNLITKQNQL----ILEISKLKDL----------QQSLVNSKSEEMTLQ 720

Query: 481  QTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQ-QLRDQENKFQ 539
              +   +I +L+QE      K    +E+  Q + QLK +L E +++ K+  L+++  + +
Sbjct: 721  INELQKEIEILRQE-----EKEKGTLEQEVQEL-QLKTELLEKQMKEKENDLQEKFAQLE 774

Query: 540  MEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEK------EEQLTRVTEVQR 593
             E S LK   EKK   L+  L      +Q++   F +++K K      E+++  + E   
Sbjct: 775  AENSILKD--EKKT--LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830

Query: 594  LQAQQADAALEEFKRQ------VELNSEKVYAEMKEQ---MEKVEADLTRSKSLREKQSK 644
               QQ     EE ++Q       E N E  Y E++E+   + KV+ DL  SK+ +E + K
Sbjct: 831  DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890

Query: 645  EFLWQL-EDIR-QRYEQQIVELKLE-HEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQL 701
              L  L E++  QR     V++K    +++KT +     AE   +    E++   L ++L
Sbjct: 891  SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV-----AETLEMGEVVEKDTTELMEKL 945

Query: 702  RAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQR 761
                 E        K   +Q ++D+  Q+ +   E+  +N + K        L++E++Q 
Sbjct: 946  EVTKRE--------KLELSQRLSDLSEQLKQKHGEISFLNEEVKS-------LKQEKEQV 990

Query: 762  A--TREHEIVVNKLKAES-EKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSS 818
            +   RE EI++N  +AE+ +    ++         MT   A   + ++ K +     + S
Sbjct: 991  SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF----GEES 1046

Query: 819  QIIAELQTTISSLK--EENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELE 876
            +I+ E + +  ++   EE+ Q+QL  +  L  V ++      Q   +ND+  K L + L+
Sbjct: 1047 KIMVEDKVSFENMTVGEESKQEQLILD-HLPSVTKESSLRATQ-PSENDKLQKEL-NVLK 1103

Query: 877  NRSNQVRC-AEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVN 935
            +  N +R   E +     L     +  +R EY    K     SL++EL   I + + ++ 
Sbjct: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVR-EYMENEKDKALCSLKEEL---IFAQEEKIK 1159

Query: 936  FLQKRASILQEELTT 950
             LQK   I Q EL T
Sbjct: 1160 ELQK---IHQLELQT 1171



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 153/706 (21%), Positives = 300/706 (42%), Gaps = 84/706 (11%)

Query: 255  KELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRK 314
            KEL++K +     +  +   L+++ +A + ++ E +  E+E L+T      HE E +  K
Sbjct: 583  KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLF-SHEEELSKLK 641

Query: 315  LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQ 374
             + +++  I     I + K++     K    Q  + L N+  +K+      M+ EK +L 
Sbjct: 642  EDLEIEHRIN----IEKLKDNLGIHYK----QQIDGLQNEMSQKIET----MQFEKDNLI 689

Query: 375  KQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQ-K 433
             +  + I E+ +  +++ + + S+    T   N + KE+E   Q+   E E   L+++ +
Sbjct: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE---EKEKGTLEQEVQ 746

Query: 434  LIQEKAE-LERCYQITCSELQE----VKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADI 488
             +Q K E LE+  +   ++LQE    ++A  + L  EK  L     ++M  + T    + 
Sbjct: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL-----EDMLKIHTPVSQEE 801

Query: 489  NLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHI 548
             L+  +   S SK S   +E+E  + +  + L++  +Q  +++  Q N F   + +    
Sbjct: 802  RLIFLDSIKSKSKDSVWEKEIE-ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN---- 856

Query: 549  YEKKAHDLQSE---LDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
            +E    +LQ E   L K K+D +   +K E   K K + L     +QR+           
Sbjct: 857  FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916

Query: 606  FKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK 665
            F       +E +  EM E +EK   +L     + +++  E   +L D+ ++ +Q+  E+ 
Sbjct: 917  FDEDKTFVAETL--EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974

Query: 666  LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIAD 725
              +E+ K+  L+Q   +    V    RE+E +    RA N++                  
Sbjct: 975  FLNEEVKS--LKQEKEQ----VSLRCRELEIIINHNRAENVQ-----------------S 1011

Query: 726  MEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELK 785
             + QV  L + ++ + S+  +     G + +  K        +V +K+  E+  +  E K
Sbjct: 1012 CDTQVSSLLDGVVTMTSRGAE-----GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066

Query: 786  KTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTIS-SLKEENSQQQLAAER 844
            +       +      S L+  +     KL K   ++   Q  +   ++ +     L    
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126

Query: 845  RLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI-TYI 903
             +  VR+  E+EK       D+A+  L++EL      +   E+K+  KEL+   Q+    
Sbjct: 1127 HVDQVREYMENEK-------DKALCSLKEEL------IFAQEEKI--KELQKIHQLELQT 1171

Query: 904  RQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELT 949
             +  ET  +G     L  +L+  +S   S   FLQ   S+L E  T
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSY--FLQTLCSVLGEYYT 1215



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 166/776 (21%), Positives = 341/776 (43%), Gaps = 136/776 (17%)

Query: 247  HFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELK-TLYRSKQ 305
            H+  +I   + +M  K+   +F ++ L  +Q      Q ILE   +++++L+ +L  SK 
Sbjct: 662  HYKQQIDGLQNEMSQKIETMQFEKDNLITKQN-----QLILEI--SKLKDLQQSLVNSKS 714

Query: 306  HETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK---KICEQSTESLNNDWEKKLHNA 362
             E    I +L+K+++ ++R  +  + T E ++ EL+   ++ E+  +   ND ++K    
Sbjct: 715  EEMTLQINELQKEIE-ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQL 773

Query: 363  VAE---MEQEKF---DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEAR 416
             AE   ++ EK    D+ K HT   QE   +  + L+ ++S+            KE+E  
Sbjct: 774  EAENSILKDEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWE-----KEIEIL 825

Query: 417  VQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLH-KEKDHLVNDYEQ 475
            ++      EN +L++Q           C Q+     +E++ +RNT    EK+  VN  E 
Sbjct: 826  IE------ENEDLKQQ-----------CIQLN----EEIEKQRNTFSFAEKNFEVNYQEL 864

Query: 476  NMK---LLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLR 532
              +   LL+ K D + +  KQE     SK  ++ EEL        Q++  + ++ K  + 
Sbjct: 865  QEEYACLLKVKDDLEDSKNKQELEYK-SKLKALNEELHL------QRINPTTVKMKSSVF 917

Query: 533  DQENKFQMEKSHLKHIYEKKAHDLQSELD---KGKEDTQKKIHKFEEALKEKEEQLTRVT 589
            D++  F  E   +  + EK   +L  +L+   + K +  +++    E LK+K  +++ + 
Sbjct: 918  DEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLN 977

Query: 590  E-VQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLRE----KQSK 644
            E V+ L+ ++   +L   + ++ +N  +         E V++  T+  SL +      S+
Sbjct: 978  EEVKSLKQEKEQVSLRCRELEIIINHNRA--------ENVQSCDTQVSSLLDGVVTMTSR 1029

Query: 645  EFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAA 704
                 +  + + + ++  ++ +E +    ++     ++++ L+ DH   +   E  LRA 
Sbjct: 1030 GAEGSVSKVNKSFGEES-KIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK-ESSLRAT 1087

Query: 705  NMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATR 764
                 +++Q+          D+  Q+   R  L  V S    Q+ E  +  E++K   + 
Sbjct: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREY-MENEKDKALCSL 1146

Query: 765  EHEIVVNKLKAESEKMKIELKKTHAAE--TEMTLEKANS---------KL-KQIEKEYTQ 812
            + E++     A+ EK+K EL+K H  E  T  T E  +          KL K + +E + 
Sbjct: 1147 KEELIF----AQEEKIK-ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSY 1201

Query: 813  KLAKSSQIIAE-----LQTTISSLKEENSQQQLAAER--RLQDVRQKFEDEKKQL----- 860
             L     ++ E     L+  +++  +ENS   ++      LQD R + +D ++ +     
Sbjct: 1202 FLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLN 1261

Query: 861  -IRDNDQAIKVLQDELENRSNQ------VRCAEKKLQHKELES---QEQITYIRQ---EY 907
             + +    + VLQ  L     Q      +   E+ L  +E E      Q+T +      +
Sbjct: 1262 KVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNH 1321

Query: 908  ETKLKGLMP-----------------ASLRQELEDTISSLKSQVNFLQKRASILQE 946
            ++KL  L                   +SL+Q+L++T  + +++++ LQKR   + E
Sbjct: 1322 KSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 161/818 (19%), Positives = 317/818 (38%), Gaps = 106/818 (12%)

Query: 203  DIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHF-------LSRIREK 255
            D+E   N   L  ++      + + +  + P     KSS F +D         +  + EK
Sbjct: 877  DLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEK 936

Query: 256  ELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKL 315
            +     + +E     EKL+L Q+  +D+ + L++K+ EI  L    +S + E E+     
Sbjct: 937  DTTELMEKLEVT-KREKLELSQRL-SDLSEQLKQKHGEISFLNEEVKSLKQEKEQ----- 989

Query: 316  EKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQK 375
               V    R+ ++I        AE  + C+    SL  D    + +  AE    K  + K
Sbjct: 990  ---VSLRCRELEIIINHNR---AENVQSCDTQVSSLL-DGVVTMTSRGAEGSVSK--VNK 1040

Query: 376  QHTENIQELLEDTNVRLNKMESEYMAQTQST-NHMIKELEARVQQLTGEAENSNLQRQ-- 432
               E  + ++ED     N    E   Q Q   +H+    +    + T  +EN  LQ++  
Sbjct: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100

Query: 433  --KLIQEKAELERCYQITCSEL---QEVKARRNTLHKEKD--------HLVNDYEQNMKL 479
              K  Q    L+   Q  C  L     V   R  +  EKD         L+   E+ +K 
Sbjct: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1160

Query: 480  LQTKYDADINLLKQE---------HALSASKASSMIEELE---QNVCQLKQQLQESELQR 527
            LQ  +  ++  +K +         H L      ++ EE     Q +C +  +     L+ 
Sbjct: 1161 LQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKC 1220

Query: 528  KQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTR 587
            +    D+EN       ++    + +  D + E+   +E+    ++K  E   E  + L  
Sbjct: 1221 EVNAEDKENS----GDYISENEDPELQDYRYEVQDFQENMHTLLNKVTE---EYNKLLVL 1273

Query: 588  VTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVE-------ADLTRSKSLRE 640
             T + ++  QQ D    EF  +     E  +  +  QM  +E       + L+  + L +
Sbjct: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333

Query: 641  KQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDH---------E 691
             + +E + +LE +    +QQ+ E +  +E E   L ++  A  +S V            E
Sbjct: 1334 TKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITE 1393

Query: 692  REIENLEKQLRAANMEHENQIQ---EF-KKRDAQVIADMEAQVHKLREE-----LINVNS 742
             + +             +  I+   EF  K +  ++  +E Q  +  EE     +++++ 
Sbjct: 1394 SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSI 1453

Query: 743  QRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSK 802
               QQ     +   +E   ++++   V  + +    +MK+   +        T E  + K
Sbjct: 1454 AFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF----QTFETVDVK 1509

Query: 803  LKQIEKEYTQKLAKSSQIIAELQTTISSLKEENS-----QQQLAAERRLQDVRQKFEDEK 857
             K+  K  +++L +  + I    +    + E         +++ ++ +   VRQ   DE 
Sbjct: 1510 FKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEI 1569

Query: 858  KQLIRDNDQAIKVLQDELEN-RSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMP 916
                 D  + + + +++LE+ R   VR  ++  Q  EL  Q  +  + ++ E        
Sbjct: 1570 SVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRED------- 1622

Query: 917  ASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGR 954
               +++L++ I  L  Q   L +R+SI  E L + + R
Sbjct: 1623 ---QEQLQEEIKRLNRQ---LAQRSSIDNENLVSERER 1654



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 141/622 (22%), Positives = 261/622 (41%), Gaps = 80/622 (12%)

Query: 382  QELLEDTNVRLNKMESEYMAQ-TQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAE 440
            Q  LE+ +V L    +E  A  T     ++  LE R+Q+         ++ Q  ++   +
Sbjct: 3032 QVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE-------QGVEYQAAMECLQK 3084

Query: 441  LERCYQITCSELQEVKARRN----TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHA 496
             +R  +   SE+Q + A+ N    TL +E++      E     +Q K      +L+ +  
Sbjct: 3085 ADR--RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS---QMLEMQVE 3139

Query: 497  LSASK--ASSMIEELEQN---VCQLKQQLQESELQRKQQLRDQ------------ENKFQ 539
            LS+ K  A+ + E+L      V +LK +L +++L+ +  L+ Q            E K +
Sbjct: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199

Query: 540  MEKSHLKH----IYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQ 595
             ++ HL +      +KK+ +LQ  L+K K     K+ + EE  KE+ E L    E Q+ +
Sbjct: 3200 TDEVHLLNDTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFSLESQKQR 3255

Query: 596  AQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQ 655
              Q +  LE+ K+ +  + +K+      + +++  D   S+        + L + E +R 
Sbjct: 3256 NLQLNLLLEQQKQLLNESQQKI------ESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3309

Query: 656  RYEQQIVELKLEHEQEKTHLLQQHNAEKDSL-VRDHEREIENLEKQLRAAN---MEHENQ 711
            R     +   L+ E+E    LQ  +    S      E  ++ L+KQL   +   +E  N+
Sbjct: 3310 RE----MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE 3365

Query: 712  IQEFKKRDAQVIADME--AQVHK---LREELINVNSQRKQQLVELGLLREEEKQRATREH 766
             +++K    Q    ME   QVH+     E+  N   Q+K   ++    + E+ QR   E 
Sbjct: 3366 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ---SKVEDLQRQLEEK 3422

Query: 767  EIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKL--KQIEKEYTQKLAKSSQIIAEL 824
               V KL  E ++++  +++    E E   ++ + ++  + + +  T  L         L
Sbjct: 3423 RQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVL 3482

Query: 825  QTTISSLKEENSQQQL--------AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELE 876
            Q  I    +E++  +L             L+ +RQK +    +L     +A + LQ E  
Sbjct: 3483 QQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETA 3542

Query: 877  NRSN----QVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQ--ELEDTISSL 930
            +  +    Q    E  LQ ++L  Q+          T    L    LRQ  EL   IS L
Sbjct: 3543 DDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQL 3602

Query: 931  KSQVNFLQKRASILQEELTTYQ 952
              + N L+     L+E++  Y+
Sbjct: 3603 TEEKNDLRNMVMKLEEQIRWYR 3624



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 119/590 (20%), Positives = 236/590 (40%), Gaps = 98/590 (16%)

Query: 249  LSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILE-----------RKNNEIEEL 297
            L  +    L++K K  E     + L  +QK   ++Q  LE           R   E+E+L
Sbjct: 3186 LKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDL 3245

Query: 298  KTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEK 357
            K    S++    +    LE++ Q L    Q I                          ++
Sbjct: 3246 KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES------------------------QR 3281

Query: 358  KLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARV 417
             L++A    EQ +          +Q LLE   VR+ +M         ST    +EL A++
Sbjct: 3282 MLYDAQLSEEQGR-------NLELQVLLESEKVRIREM--------SSTLDRERELHAQL 3326

Query: 418  QQLTGEAEN-SNLQRQKLIQE-KAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ 475
            Q   G  ++   L  + L++E + +LE  +      L E +  +    + +  +  D + 
Sbjct: 3327 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQV 3386

Query: 476  NMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESEL--QRKQQLRD 533
            + K LQT+ +A+    K+ H L      S +E+L++ + + +QQ+ + +L  QR Q +  
Sbjct: 3387 HRKTLQTEQEANTEGQKKMHEL-----QSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ 3441

Query: 534  QENKFQMEKSHLKH----IYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVT 589
            +  K ++E+   +     +Y+         L   +        K E   + KE    ++ 
Sbjct: 3442 EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG--ETKESNYAKLI 3499

Query: 590  EVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQ 649
            E+        +  LE  +++++  + K+    ++  E+++ +            ++F+W 
Sbjct: 3500 EMNG-GGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETA--------DDEDFIWV 3550

Query: 650  LEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANME-- 707
             E+I    ++ I++L+          L     E+ SLV        +L ++L   N E  
Sbjct: 3551 QENI----DEIILQLQ---------KLTGQQGEEPSLV-SPSTSCGSLTERLLRQNAELT 3596

Query: 708  -HENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQL---VELGLLREEEKQRAT 763
             H +Q+ E K     ++  +E Q+   R+     ++  +  L     +  +   EK+   
Sbjct: 3597 GHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWN 3656

Query: 764  REHEIVVNKLK---AESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEY 810
            RE   +   LK   AE  K+K EL+     +T ++ +  +  LK+I  +Y
Sbjct: 3657 REKLTLQKSLKRAEAEVYKLKAELRNDSLLQT-LSPDSEHVTLKRIYGKY 3705



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 134/725 (18%), Positives = 283/725 (39%), Gaps = 75/725 (10%)

Query: 272  KLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRE 331
            K KL    D +  K+ E    +++EL++L  S Q + +ET +  E ++  L +  Q + E
Sbjct: 1322 KSKLSSLQDLEKTKLEE----QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377

Query: 332  TKEDQIAELKKICEQSTESLNNDWE----KKLHNAVAEME-----QEKFDLQKQHTENIQ 382
            +       +  +    +++    +     KK  +   E       +E+ ++ K   +  Q
Sbjct: 1378 STVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQ 1437

Query: 383  ELLEDTNVRLNKMESEYMAQTQSTNHMI--KELEARVQQLTG--EAENSNLQRQKLIQEK 438
            E LE+   ++    S   AQ    + +   KE  A  +Q     + E       KL Q++
Sbjct: 1438 EQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQ 1497

Query: 439  AELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALS 498
               +    +     +E K     L +    ++        + ++K   D  L   E   S
Sbjct: 1498 IGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESK---DCVLTISEEMFS 1554

Query: 499  ASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQS 558
              K   + + +   +           +  ++QL D   +   +    +   E        
Sbjct: 1555 KDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR 1614

Query: 559  ELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEV--QRLQAQQADAALEEFKRQVELN--- 613
            ++++ +ED +    + +E +K    QL + + +  + L +++    LEE +   +L+   
Sbjct: 1615 QMERQREDQE----QLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAG 1670

Query: 614  SEKVYAEMKEQMEKVEADLTRSKSLREK--QSKEFLWQLEDI------RQRYEQQIVE-- 663
             EK+  E++    + +        + E+  + KE   + ED+       +RY  Q     
Sbjct: 1671 REKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNR 1730

Query: 664  -LKLEHEQEKTHLLQQHN--------AEKDSLVRDHEREIENLEKQLRAANMEHENQIQE 714
             LK+  E  KT    +           ++ S  +     I   E +    +  HE   + 
Sbjct: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790

Query: 715  FKKR-DAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKL 773
              +   +   +DM      +  ++    ++  Q+LV  G    E           + ++L
Sbjct: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850

Query: 774  KAESEKMKIELKKT-----HAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTI 828
            +A  EK+   + +T     HA  T+  L + + + KQ   E T+ L    ++   L    
Sbjct: 1851 QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ---EATESLKCQEELRERLH--- 1904

Query: 829  SSLKEENSQQQLAAE-RRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK 887
               +E  +++QLA E  + + V   + DEK       ++ I+   D ++    ++ CA  
Sbjct: 1905 ---EESRAREQLAVELSKAEGVIDGYADEKTLF----ERQIQEKTDIIDRLEQELLCASN 1957

Query: 888  KLQHKELESQEQITYIRQEYETKLKGLMPASL----RQELEDTISSLKSQVNFLQKRASI 943
            +LQ  ELE+++Q     +E  ++ K  M A      +Q L++T   +K ++  +Q +A  
Sbjct: 1958 RLQ--ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE-VQCQAEK 2014

Query: 944  LQEEL 948
            ++++L
Sbjct: 2015 VRDDL 2019



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 154/772 (19%), Positives = 291/772 (37%), Gaps = 143/772 (18%)

Query: 292  NEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESL 351
            NE  EL+  YR +  + +E +  L  KV        V++         L KI  Q T+ +
Sbjct: 1237 NEDPELQD-YRYEVQDFQENMHTLLNKVTEEYNKLLVLQ-------TRLSKIWGQQTDGM 1288

Query: 352  NNDWEKK-----------LHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYM 400
              ++ ++           +H+ +  +E    D+   H   +  L +    +L +   E  
Sbjct: 1289 KLEFGEENLPKEETEFLSIHSQMTNLE----DIDVNHKSKLSSLQDLEKTKLEEQVQELE 1344

Query: 401  AQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRN 460
            +   S    +KE E        EAE   LQ++     ++ +     +    + E  A+R 
Sbjct: 1345 SLISSLQQQLKETEQNY-----EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399

Query: 461  -------------TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIE 507
                         T+    +  V +    +KLL+ +Y   +     +  +S S A +   
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459

Query: 508  EL------EQNVCQLKQQ----LQESELQRKQQLRDQENKFQ-MEKSHLKHIYEKKAHDL 556
            EL      ++N    KQ      QE     + +L   +  FQ  E   +K  ++++   L
Sbjct: 1460 ELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVK--FKEEFKPL 1517

Query: 557  QSEL-DKGKED--TQKKIHKFEEA------LKEKEEQLTRVTEVQRLQAQQADAALEEFK 607
              EL + GKE   +    H   E+      + E+     +   V++    +   +  +  
Sbjct: 1518 SKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDAS 1577

Query: 608  RQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLE 667
            RQ+ LN E++    +E + + +     ++ LR+   +    Q+E  RQR +Q+  +L+ E
Sbjct: 1578 RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR----QME--RQREDQE--QLQEE 1629

Query: 668  HEQEKTHLLQQHNAEKDSLVRDHERE-IENLE--KQLRAANME----------------H 708
             ++    L Q+ + + ++LV + ER  +E LE  KQL  A  E                +
Sbjct: 1630 IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689

Query: 709  ENQ----IQEFKKRD---------AQVIADMEAQVHKLREELINVNSQ--RKQQLVE--- 750
            ENQ     Q FK+++          +++++    + K    L+ +  +  +    VE   
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749

Query: 751  ----LGLLREEEKQRAT------REHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKAN 800
                LG+L    K +++       E E  V     E      +      + ++M     N
Sbjct: 1750 GRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDIN 1809

Query: 801  --SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKK 858
              SK+ +   E +Q+L +S     E+         EN +  L    RLQ   +K  +   
Sbjct: 1810 MWSKVTEEGTELSQRLVRSGFAGTEID-------PENEELMLNISSRLQAAVEKLLEAIS 1862

Query: 859  QLIRDNDQAIKVLQDEL--------ENRSNQVRCAE--KKLQHKELESQEQITYIRQEYE 908
            +     + A KV Q EL        +  +  ++C E  ++  H+E  ++EQ+     + E
Sbjct: 1863 ETSSQLEHA-KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE 1921

Query: 909  TKLKGLMPASLR-----QELEDTISSLKSQVNFLQKRASILQEELTTYQGRR 955
              + G            QE  D I  L+ ++     R   L+ E    Q  R
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEER 1973


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/727 (23%), Positives = 315/727 (43%), Gaps = 129/727 (17%)

Query: 246 DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNE-IEELKTLYRSK 304
           DH L   ++K+ D     M+  F +EK+K+   ++ +  K +E  N E I+E +T+    
Sbjct: 281 DHLLEDYQKKKEDFT---MQISFLQEKIKV---YEMEQDKKVENSNKEEIQEKETIIE-- 332

Query: 305 QHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVA 364
             E    I + EKK   L           +D++    K+  +  E +     +++ N   
Sbjct: 333 --ELNTKIIEEEKKTLEL-----------KDKLTTADKLLGELQEQIVQK-NQEIKNMKL 378

Query: 365 EMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEA 424
           E+   K   ++Q +E I++L+        +   +   +T     M +E + +++QL   A
Sbjct: 379 ELTNSK-QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQL--RA 435

Query: 425 ENSNLQRQKLIQEKAELERCYQITCSELQEVKARR-----NTLHKEKDHLVNDYEQNMKL 479
           E   +  Q+++Q K EL R +    ++++E+K R      N L    +  VN  E  +KL
Sbjct: 436 ELDEMYGQQIVQMKQELIRQHM---AQMEEMKTRHKGEMENALRSYSNITVN--EDQIKL 490

Query: 480 LQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE---------SELQR-KQ 529
           +    + ++N+  Q+      K    +  + +  C L++QL++          ++QR +Q
Sbjct: 491 MNVAIN-ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549

Query: 530 QLRDQENKFQMEKSHLKHIYEKKAHDLQS-------ELDKGKEDTQKKIHKFEEALKEKE 582
            + +QE+K       L  + + KA  + +       EL    E T  KI K E   KEK 
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI-KLEMLEKEKN 608

Query: 583 EQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQ 642
             L R+ E Q       +A LE  + Q+  + E+  +++KE +E +E  +   K      
Sbjct: 609 AVLDRMAESQ-------EAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEKLK---- 656

Query: 643 SKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLR 702
                   +++   Y+QQI  L+ E  Q+    ++    EKD+L+    + I  + K   
Sbjct: 657 --------DNLGIHYKQQIDGLQNEMSQK----IETMQFEKDNLITKQNQLILEISKL-- 702

Query: 703 AANMEHENQIQEFKKRDAQVIADMEAQVHKLREEL-INVNSQRKQQLVELGLLREEEKQR 761
                          +D Q     ++ V+   EE+ + +N  +K    E+ +LR+EEK++
Sbjct: 703 ---------------KDLQ-----QSLVNSKSEEMTLQINELQK----EIEILRQEEKEK 738

Query: 762 ATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQII 821
            T E E+   +LK E  + +++ K+    E    LE  NS LK  EK+  + + K    +
Sbjct: 739 GTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD-EKKTLEDMLKIHTPV 797

Query: 822 AELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQ 881
           ++ +  I     ++  +    E+ ++ + ++ ED K+Q I+        L +E+E + N 
Sbjct: 798 SQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ--------LNEEIEKQRNT 849

Query: 882 VRCAEKKLQHKELESQEQITYIRQ--------------EYETKLKGLMPASLRQELEDTI 927
              AEK  +    E QE+   + +              EY++KLK L      Q +  T 
Sbjct: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909

Query: 928 SSLKSQV 934
             +KS V
Sbjct: 910 VKMKSSV 916



 Score =  116 bits (291), Expect = 9e-26
 Identities = 160/773 (20%), Positives = 342/773 (44%), Gaps = 111/773 (14%)

Query: 252  IREKEL---DMKTKMMEAKFH----EEKLKLQQKHDADVQKILERKNNEIEELK---TLY 301
            I+EKE    ++ TK++E +      ++KL    K   ++Q+ + +KN EI+ +K   T  
Sbjct: 324  IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383

Query: 302  RSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHN 361
            + K+ ++ E I++L   V+ L +      + + D +  +++  ++  E L  + ++    
Sbjct: 384  KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQ 443

Query: 362  AVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLT 421
             + +M+QE   L +QH   ++E+       +      Y   T + +  IK +   + +L 
Sbjct: 444  QIVQMKQE---LIRQHMAQMEEMKTRHKGEMENALRSYSNITVNED-QIKLMNVAINELN 499

Query: 422  GEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQ 481
             + +++N Q++KL +E   +          L+E  A +  L    + L    EQ  +  Q
Sbjct: 500  IKLQDTNSQKEKLKEELGLI----------LEEKCALQRQLEDLVEELSFSREQIQRARQ 549

Query: 482  TKYDADINLLKQEHALS-ASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540
            T       + +QE  L+ A K+ S +E+L+  +    +  +E EL+ + ++ + + K +M
Sbjct: 550  T-------IAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602

Query: 541  EKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEE-QLTRVTEVQRLQ---- 595
             +     + ++ A   ++EL++ +  TQ      EE  K KE+ ++     +++L+    
Sbjct: 603  LEKEKNAVLDRMAESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660

Query: 596  ---AQQADAALEEFKRQVE-LNSEKVYAEMKE--------QMEKVEADLTRSKS------ 637
                QQ D    E  +++E +  EK     K+        +++ ++  L  SKS      
Sbjct: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720

Query: 638  LREKQSK-EFLWQLEDIRQRYEQQIVELKLEHE------QEKTHLLQQHNAE---KDSLV 687
            + E Q + E L Q E  +   EQ++ EL+L+ E      +EK + LQ+  A+   ++S++
Sbjct: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780

Query: 688  RDHEREIENLEK-QLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQ 746
            +D ++ +E++ K     +  E    +   K +    + + E ++      LI  N   KQ
Sbjct: 781  KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------LIEENEDLKQ 834

Query: 747  QLVELGLLREEEKQR-----ATREHEIVVNKLKAE--------------SEKMKIELK-K 786
            Q ++L    E EKQR     A +  E+   +L+ E                K ++E K K
Sbjct: 835  QCIQLN--EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSK 892

Query: 787  THAAETEMTLEKAN-------SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQ 839
              A   E+ L++ N       S +   +K +  +  +  +++ +  T +    E   +++
Sbjct: 893  LKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREK 952

Query: 840  LAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQ 899
            L   +RL D+ ++ + +  ++   N++ +K L+ E E  S + R  E  + H   E+   
Sbjct: 953  LELSQRLSDLSEQLKQKHGEISFLNEE-VKSLKQEKEQVSLRCRELEIIINHNRAENV-- 1009

Query: 900  ITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
                 Q  +T++  L+   +         S+        + + I+ E+  +++
Sbjct: 1010 -----QSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057



 Score =  105 bits (263), Expect = 2e-22
 Identities = 154/718 (21%), Positives = 309/718 (43%), Gaps = 134/718 (18%)

Query: 297 LKTLYRSK--QHETEETIRKLEKKVQTLIRDCQ--------VIRETKEDQIAELKKICEQ 346
           ++TL+  +   HE   ++ +LE ++ T   DC         V+R  K   +   ++    
Sbjct: 84  MRTLHSGEITSHEQGFSV-ELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVD 142

Query: 347 STESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQST 406
            + S     +   H    EM + +   ++   E +   LE+  V      +E + Q Q  
Sbjct: 143 DSYSEQGAQDSPTH---LEMMESELAGKQHEIEELNRELEEMRVTYG---TEGLQQLQEF 196

Query: 407 NHMIKELEARVQQLTGEAENSNLQRQKLIQEKAEL---ERCYQITCSELQEVKARRNTLH 463
              IK+ +  + QLT   + +  ++ + ++E  EL    +  QI   +LQ  +  RN+ H
Sbjct: 197 EAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTH 256

Query: 464 ---------------------KEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKA 502
                                +E+DHL+ DY++                K++  +  S  
Sbjct: 257 SSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK---------------KEDFTMQISFL 301

Query: 503 SSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSEL-- 560
              I+  E    +  +   + E+Q K+ + ++ N   +E+       EKK  +L+ +L  
Sbjct: 302 QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE-------EKKTLELKDKLTT 354

Query: 561 -DKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYA 619
            DK   + Q++I +  + +K  + +LT   + +R    Q+   +++    VE        
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKER----QSSEEIKQLMGTVE-------- 402

Query: 620 EMKEQMEKVEADLTRSKSLREKQSKEFLWQLE-DIRQRYEQQIVELKLEHEQEKTHLLQQ 678
           E++++  K     T      E++++  L QL  ++ + Y QQIV++K E       L++Q
Sbjct: 403 ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQE-------LIRQ 455

Query: 679 HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELI 738
           H A+ + +   H+ E+EN    LR+ +    N+ Q         I  M   +++L  +L 
Sbjct: 456 HMAQMEEMKTRHKGEMEN---ALRSYSNITVNEDQ---------IKLMNVAINELNIKLQ 503

Query: 739 NVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEK 798
           + NSQ+++   ELGL+  EEK    R+ E +V +L    E  +I+  +   AE E  L +
Sbjct: 504 DTNSQKEKLKEELGLIL-EEKCALQRQLEDLVEELSFSRE--QIQRARQTIAEQESKLNE 560

Query: 799 ANSKLKQIEKEYTQKLA-----KSSQIIAELQTTISSLKEE--NSQQQLAAERRLQDVRQ 851
           A+  L  +E    + ++     K  ++  E + T   +K E    ++    +R  +    
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620

Query: 852 KFEDEKKQLIRDNDQAIKVLQD--ELENRSNQVRCAEKKLQHKELESQEQITYIRQEYET 909
           + E  + QL+  +++ +  L++  E+E+R N     EK   +  +  ++QI  ++ E   
Sbjct: 621 ELERLRTQLLFSHEEELSKLKEDLEIEHRIN----IEKLKDNLGIHYKQQIDGLQNEMSQ 676

Query: 910 KLKG---------------LMPASLRQELEDTISSLKS-----QVNFLQKRASILQEE 947
           K++                ++  S  ++L+ ++ + KS     Q+N LQK   IL++E
Sbjct: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE 734



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 155/776 (19%), Positives = 341/776 (43%), Gaps = 107/776 (13%)

Query: 230  LMTPKFSLRKSSSFHDDHFLSRIREKELDMKTKM-----MEAKFHEEKLKLQQKHDADVQ 284
            LM  K  ++  +    D    +++  E+D++ ++     +E + + E + L+Q++ A ++
Sbjct: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA-LE 2059

Query: 285  KILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKIC 344
            K LE+    ++E       ++   ++ I+KLE++++ + R  Q I E +  ++ +L    
Sbjct: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR-FQPISEHQTREVEQLANHL 2118

Query: 345  EQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQ 404
            ++ T+        K    +   EQ + D+Q+++ E     +E    R+ ++E   + + +
Sbjct: 2119 KEKTD--------KCSELLLSKEQLQRDIQERNEE-----IEKLEFRVRELEQALLVEDR 2165

Query: 405  STNHMIK---ELEARVQQLTG-------EAENSNLQRQKLIQEKAELERCYQITCSELQE 454
                 ++   EL   VQ           E E +NL+ Q L Q + ELE   +    E+Q+
Sbjct: 2166 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQ-LEQFREELENKNE----EVQQ 2220

Query: 455  VKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSAS-------KASSMIE 507
            +  +     KE    + + EQ  KL +   +     +K+  A+S         K + +I+
Sbjct: 2221 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2280

Query: 508  ELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDT 567
            E E  + QL +Q+ + + Q K      +NK   EK+ L    E +   L S+ +  K + 
Sbjct: 2281 EKEVEIDQLNEQVTKLQQQLKITT---DNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337

Query: 568  QKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK 627
            +++I +  E +++ +++L  + +   + A       +  K Q+++   +  A +++Q+E 
Sbjct: 2338 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA-LEQQVET 2396

Query: 628  VEADLTRSKS-LREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQ-EKTHLLQQH--NAEK 683
               ++T  K+ L+E   K           +  Q++  LK E E  EK   + ++  N   
Sbjct: 2397 ANEEMTFMKNVLKETNFK---------MNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2447

Query: 684  DSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQ 743
            D L +D + E+E +  +    ++E++   + F++     I ++E ++ +L   +   + +
Sbjct: 2448 DHLSKD-KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506

Query: 744  RKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKL 803
              Q   ++  ++E+ +       + +VN  K   EK+                  A + +
Sbjct: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKV------------------AAALV 2548

Query: 804  KQIEKEYTQKLAKSSQ----IIAELQTT----ISSLKEENSQQQLAA--------ERRLQ 847
             QI+ E  Q+ AK  Q    I +E + T    ++ L+E+     ++A        E ++ 
Sbjct: 2549 SQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVV 2608

Query: 848  DVRQKFEDEKKQL------IRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQIT 901
            ++      EK+Q+      + + ++ +  LQ  LE    + R  EKK   +++E  +  T
Sbjct: 2609 EMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2668

Query: 902  YIRQEYE-----TKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQ 952
             +    E      +L+ L   S+  + E  ++S K +   LQ+   + +  +T+ Q
Sbjct: 2669 ELFHSNEESGFFNELEALRAESVATKAE--LASYKEKAEKLQEELLVKETNMTSLQ 2722



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 165/735 (22%), Positives = 325/735 (44%), Gaps = 102/735 (13%)

Query: 258  DMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEK 317
            ++  K+ +    +EKLK +     + +  L+R+  ++ E  +  R +     +TI + E 
Sbjct: 497  ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQES 556

Query: 318  KVQTLIRDCQVIRETKEDQIA--------ELKKICEQSTESLNNDWEKKLHNAV------ 363
            K+    +    + + K + ++        ELK   E +   +  +  +K  NAV      
Sbjct: 557  KLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616

Query: 364  ---AEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQL 420
               AE+E+ +  L   H E + +L ED  +  +++  E +       H  ++++    ++
Sbjct: 617  SQEAELERLRTQLLFSHEEELSKLKEDLEIE-HRINIEKLKDNLGI-HYKQQIDGLQNEM 674

Query: 421  TGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLL 480
            + + E    ++  LI ++ +L     +  S+L+++          +  LVN   + M L 
Sbjct: 675  SQKIETMQFEKDNLITKQNQL----ILEISKLKDL----------QQSLVNSKSEEMTLQ 720

Query: 481  QTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQ-QLRDQENKFQ 539
              +   +I +L+QE      K    +E+  Q + QLK +L E +++ K+  L+++  + +
Sbjct: 721  INELQKEIEILRQE-----EKEKGTLEQEVQEL-QLKTELLEKQMKEKENDLQEKFAQLE 774

Query: 540  MEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEK------EEQLTRVTEVQR 593
             E S LK   EKK   L+  L      +Q++   F +++K K      E+++  + E   
Sbjct: 775  AENSILKD--EKKT--LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830

Query: 594  LQAQQADAALEEFKRQ------VELNSEKVYAEMKEQ---MEKVEADLTRSKSLREKQSK 644
               QQ     EE ++Q       E N E  Y E++E+   + KV+ DL  SK+ +E + K
Sbjct: 831  DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890

Query: 645  EFLWQL-EDIR-QRYEQQIVELKLE-HEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQL 701
              L  L E++  QR     V++K    +++KT +     AE   +    E++   L ++L
Sbjct: 891  SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV-----AETLEMGEVVEKDTTELMEKL 945

Query: 702  RAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQR 761
                 E        K   +Q ++D+  Q+ +   E+  +N + K        L++E++Q 
Sbjct: 946  EVTKRE--------KLELSQRLSDLSEQLKQKHGEISFLNEEVKS-------LKQEKEQV 990

Query: 762  A--TREHEIVVNKLKAES-EKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSS 818
            +   RE EI++N  +AE+ +    ++         MT   A   + ++ K +     + S
Sbjct: 991  SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF----GEES 1046

Query: 819  QIIAELQTTISSLK--EENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELE 876
            +I+ E + +  ++   EE+ Q+QL  +  L  V ++      Q   +ND+  K L + L+
Sbjct: 1047 KIMVEDKVSFENMTVGEESKQEQLILD-HLPSVTKESSLRATQ-PSENDKLQKEL-NVLK 1103

Query: 877  NRSNQVRC-AEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVN 935
            +  N +R   E +     L     +  +R EY    K     SL++EL   I + + ++ 
Sbjct: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVR-EYMENEKDKALCSLKEEL---IFAQEEKIK 1159

Query: 936  FLQKRASILQEELTT 950
             LQK   I Q EL T
Sbjct: 1160 ELQK---IHQLELQT 1171



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 147/739 (19%), Positives = 331/739 (44%), Gaps = 81/739 (10%)

Query: 252  IREKEL-DMKTKMM-EAKFHEEKLKL-QQKHDADVQKILERKNNEIEELKTLYRS-KQHE 307
            + E++L DM+ +++ + + H++  +L +Q H   +++  E +    EE+K L R   Q  
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641

Query: 308  TEETIRKLEKKVQTLIRDCQVIRET----KEDQIAELKKICEQSTESLNNDWEKKLHN-A 362
            + +    + ++ + L+ + + +++     +E    EL+    Q+     N  E +     
Sbjct: 1642 SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK 1701

Query: 363  VAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTG 422
              E++++  D+  +   N +  L+  N RL K+  E +  T +    I      +   + 
Sbjct: 1702 EKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSS 1761

Query: 423  EAENSNLQRQKLI---QEKAELERCY-----QITCSELQEVKAR---RNTLHKEKDHLVN 471
            ++++S      LI   + +A ++ C      ++T   +         RN ++        
Sbjct: 1762 KSQSS----ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE 1817

Query: 472  DYEQNMKLLQTKY-DADINLLKQEHALS-ASKASSMIEELEQNVCQLKQQLQESELQRKQ 529
              E + +L+++ +   +I+   +E  L+ +S+  + +E+L + + +   QL+ +++ + +
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877

Query: 530  QLRDQENKFQMEKSHLK---------HIYEKKAHDLQSELDKGK---EDTQKKIHKFEEA 577
             +R+   + Q     LK         H   +    L  EL K +   +    +   FE  
Sbjct: 1878 LMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQ 1937

Query: 578  LKEKEEQLTRVTE---VQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTR 634
            ++EK + + R+ +       + Q+ +A  ++ + + EL S +  A MK +   VE  L +
Sbjct: 1938 IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA-MKAEAGPVEQQLLQ 1996

Query: 635  SKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREI 694
                  K+  E   Q E +R   ++Q+  L+++ E++ +  ++    EK++ + D  ++ 
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ-EKNTELMDLRQQN 2055

Query: 695  ENLEKQL-RAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL 753
            + LEKQL +      E  I    +RD       + ++ KL ++L  V   R Q + E   
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDV-----FQQEIQKLEQQLKVV--PRFQPISE--- 2105

Query: 754  LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQK 813
                     TRE E + N LK +++K            +E+ L K   +L++  +E  ++
Sbjct: 2106 -------HQTREVEQLANHLKEKTDKC-----------SELLLSK--EQLQRDIQERNEE 2145

Query: 814  LAKSSQIIAELQTTISSLKEEN-----SQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAI 868
            + K    + EL+  +     ++     ++ +L+ E +LQ  R    D K++ I + ++ +
Sbjct: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAI-DRKEKEITNLEEQL 2204

Query: 869  KVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTIS 928
            +  ++ELEN++ +V+    +L+ ++ ES  ++  + QE +     +    L  +  D +S
Sbjct: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS 2264

Query: 929  SLKSQVNFLQKRASILQEE 947
            +    V F  K A I+QE+
Sbjct: 2265 TQDQHVLF-GKFAQIIQEK 2282



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 153/706 (21%), Positives = 300/706 (42%), Gaps = 84/706 (11%)

Query: 255  KELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRK 314
            KEL++K +     +  +   L+++ +A + ++ E +  E+E L+T      HE E +  K
Sbjct: 583  KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLF-SHEEELSKLK 641

Query: 315  LEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQ 374
             + +++  I     I + K++     K    Q  + L N+  +K+      M+ EK +L 
Sbjct: 642  EDLEIEHRIN----IEKLKDNLGIHYK----QQIDGLQNEMSQKIET----MQFEKDNLI 689

Query: 375  KQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQ-K 433
             +  + I E+ +  +++ + + S+    T   N + KE+E   Q+   E E   L+++ +
Sbjct: 690  TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE---EKEKGTLEQEVQ 746

Query: 434  LIQEKAE-LERCYQITCSELQE----VKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADI 488
             +Q K E LE+  +   ++LQE    ++A  + L  EK  L     ++M  + T    + 
Sbjct: 747  ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL-----EDMLKIHTPVSQEE 801

Query: 489  NLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHI 548
             L+  +   S SK S   +E+E  + +  + L++  +Q  +++  Q N F   + +    
Sbjct: 802  RLIFLDSIKSKSKDSVWEKEIE-ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN---- 856

Query: 549  YEKKAHDLQSE---LDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
            +E    +LQ E   L K K+D +   +K E   K K + L     +QR+           
Sbjct: 857  FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916

Query: 606  FKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK 665
            F       +E +  EM E +EK   +L     + +++  E   +L D+ ++ +Q+  E+ 
Sbjct: 917  FDEDKTFVAETL--EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974

Query: 666  LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIAD 725
              +E+ K+  L+Q   +    V    RE+E +    RA N++                  
Sbjct: 975  FLNEEVKS--LKQEKEQ----VSLRCRELEIIINHNRAENVQ-----------------S 1011

Query: 726  MEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELK 785
             + QV  L + ++ + S+  +     G + +  K        +V +K+  E+  +  E K
Sbjct: 1012 CDTQVSSLLDGVVTMTSRGAE-----GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066

Query: 786  KTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTIS-SLKEENSQQQLAAER 844
            +       +      S L+  +     KL K   ++   Q  +   ++ +     L    
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126

Query: 845  RLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQI-TYI 903
             +  VR+  E+EK       D+A+  L++EL      +   E+K+  KEL+   Q+    
Sbjct: 1127 HVDQVREYMENEK-------DKALCSLKEEL------IFAQEEKI--KELQKIHQLELQT 1171

Query: 904  RQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELT 949
             +  ET  +G     L  +L+  +S   S   FLQ   S+L E  T
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSY--FLQTLCSVLGEYYT 1215



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 166/776 (21%), Positives = 341/776 (43%), Gaps = 136/776 (17%)

Query: 247  HFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELK-TLYRSKQ 305
            H+  +I   + +M  K+   +F ++ L  +Q      Q ILE   +++++L+ +L  SK 
Sbjct: 662  HYKQQIDGLQNEMSQKIETMQFEKDNLITKQN-----QLILEI--SKLKDLQQSLVNSKS 714

Query: 306  HETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK---KICEQSTESLNNDWEKKLHNA 362
             E    I +L+K+++ ++R  +  + T E ++ EL+   ++ E+  +   ND ++K    
Sbjct: 715  EEMTLQINELQKEIE-ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQL 773

Query: 363  VAE---MEQEKF---DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEAR 416
             AE   ++ EK    D+ K HT   QE   +  + L+ ++S+            KE+E  
Sbjct: 774  EAENSILKDEKKTLEDMLKIHTPVSQE---ERLIFLDSIKSKSKDSVWE-----KEIEIL 825

Query: 417  VQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLH-KEKDHLVNDYEQ 475
            ++      EN +L++Q           C Q+     +E++ +RNT    EK+  VN  E 
Sbjct: 826  IE------ENEDLKQQ-----------CIQLN----EEIEKQRNTFSFAEKNFEVNYQEL 864

Query: 476  NMK---LLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLR 532
              +   LL+ K D + +  KQE     SK  ++ EEL        Q++  + ++ K  + 
Sbjct: 865  QEEYACLLKVKDDLEDSKNKQELEYK-SKLKALNEELHL------QRINPTTVKMKSSVF 917

Query: 533  DQENKFQMEKSHLKHIYEKKAHDLQSELD---KGKEDTQKKIHKFEEALKEKEEQLTRVT 589
            D++  F  E   +  + EK   +L  +L+   + K +  +++    E LK+K  +++ + 
Sbjct: 918  DEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLN 977

Query: 590  E-VQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLRE----KQSK 644
            E V+ L+ ++   +L   + ++ +N  +         E V++  T+  SL +      S+
Sbjct: 978  EEVKSLKQEKEQVSLRCRELEIIINHNRA--------ENVQSCDTQVSSLLDGVVTMTSR 1029

Query: 645  EFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAA 704
                 +  + + + ++  ++ +E +    ++     ++++ L+ DH   +   E  LRA 
Sbjct: 1030 GAEGSVSKVNKSFGEES-KIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK-ESSLRAT 1087

Query: 705  NMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATR 764
                 +++Q+          D+  Q+   R  L  V S    Q+ E  +  E++K   + 
Sbjct: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREY-MENEKDKALCSL 1146

Query: 765  EHEIVVNKLKAESEKMKIELKKTHAAE--TEMTLEKANS---------KL-KQIEKEYTQ 812
            + E++     A+ EK+K EL+K H  E  T  T E  +          KL K + +E + 
Sbjct: 1147 KEELIF----AQEEKIK-ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSY 1201

Query: 813  KLAKSSQIIAE-----LQTTISSLKEENSQQQLAAER--RLQDVRQKFEDEKKQL----- 860
             L     ++ E     L+  +++  +ENS   ++      LQD R + +D ++ +     
Sbjct: 1202 FLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLN 1261

Query: 861  -IRDNDQAIKVLQDELENRSNQ------VRCAEKKLQHKELES---QEQITYIRQ---EY 907
             + +    + VLQ  L     Q      +   E+ L  +E E      Q+T +      +
Sbjct: 1262 KVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNH 1321

Query: 908  ETKLKGLMP-----------------ASLRQELEDTISSLKSQVNFLQKRASILQE 946
            ++KL  L                   +SL+Q+L++T  + +++++ LQKR   + E
Sbjct: 1322 KSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 161/818 (19%), Positives = 317/818 (38%), Gaps = 106/818 (12%)

Query: 203  DIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSSFHDDHF-------LSRIREK 255
            D+E   N   L  ++      + + +  + P     KSS F +D         +  + EK
Sbjct: 877  DLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEK 936

Query: 256  ELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKL 315
            +     + +E     EKL+L Q+  +D+ + L++K+ EI  L    +S + E E+     
Sbjct: 937  DTTELMEKLEVT-KREKLELSQRL-SDLSEQLKQKHGEISFLNEEVKSLKQEKEQ----- 989

Query: 316  EKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQK 375
               V    R+ ++I        AE  + C+    SL  D    + +  AE    K  + K
Sbjct: 990  ---VSLRCRELEIIINHNR---AENVQSCDTQVSSLL-DGVVTMTSRGAEGSVSK--VNK 1040

Query: 376  QHTENIQELLEDTNVRLNKMESEYMAQTQST-NHMIKELEARVQQLTGEAENSNLQRQ-- 432
               E  + ++ED     N    E   Q Q   +H+    +    + T  +EN  LQ++  
Sbjct: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100

Query: 433  --KLIQEKAELERCYQITCSEL---QEVKARRNTLHKEKD--------HLVNDYEQNMKL 479
              K  Q    L+   Q  C  L     V   R  +  EKD         L+   E+ +K 
Sbjct: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1160

Query: 480  LQTKYDADINLLKQE---------HALSASKASSMIEELE---QNVCQLKQQLQESELQR 527
            LQ  +  ++  +K +         H L      ++ EE     Q +C +  +     L+ 
Sbjct: 1161 LQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKC 1220

Query: 528  KQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTR 587
            +    D+EN       ++    + +  D + E+   +E+    ++K  E   E  + L  
Sbjct: 1221 EVNAEDKENS----GDYISENEDPELQDYRYEVQDFQENMHTLLNKVTE---EYNKLLVL 1273

Query: 588  VTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVE-------ADLTRSKSLRE 640
             T + ++  QQ D    EF  +     E  +  +  QM  +E       + L+  + L +
Sbjct: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333

Query: 641  KQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDH---------E 691
             + +E + +LE +    +QQ+ E +  +E E   L ++  A  +S V            E
Sbjct: 1334 TKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITE 1393

Query: 692  REIENLEKQLRAANMEHENQIQ---EF-KKRDAQVIADMEAQVHKLREE-----LINVNS 742
             + +             +  I+   EF  K +  ++  +E Q  +  EE     +++++ 
Sbjct: 1394 SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSI 1453

Query: 743  QRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSK 802
               QQ     +   +E   ++++   V  + +    +MK+   +        T E  + K
Sbjct: 1454 AFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF----QTFETVDVK 1509

Query: 803  LKQIEKEYTQKLAKSSQIIAELQTTISSLKEENS-----QQQLAAERRLQDVRQKFEDEK 857
             K+  K  +++L +  + I    +    + E         +++ ++ +   VRQ   DE 
Sbjct: 1510 FKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEI 1569

Query: 858  KQLIRDNDQAIKVLQDELEN-RSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMP 916
                 D  + + + +++LE+ R   VR  ++  Q  EL  Q  +  + ++ E        
Sbjct: 1570 SVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRED------- 1622

Query: 917  ASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGR 954
               +++L++ I  L  Q   L +R+SI  E L + + R
Sbjct: 1623 ---QEQLQEEIKRLNRQ---LAQRSSIDNENLVSERER 1654



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 141/622 (22%), Positives = 261/622 (41%), Gaps = 80/622 (12%)

Query: 382  QELLEDTNVRLNKMESEYMAQ-TQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAE 440
            Q  LE+ +V L    +E  A  T     ++  LE R+Q+         ++ Q  ++   +
Sbjct: 3024 QVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE-------QGVEYQAAMECLQK 3076

Query: 441  LERCYQITCSELQEVKARRN----TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHA 496
             +R  +   SE+Q + A+ N    TL +E++      E     +Q K      +L+ +  
Sbjct: 3077 ADR--RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS---QMLEMQVE 3131

Query: 497  LSASK--ASSMIEELEQN---VCQLKQQLQESELQRKQQLRDQ------------ENKFQ 539
            LS+ K  A+ + E+L      V +LK +L +++L+ +  L+ Q            E K +
Sbjct: 3132 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191

Query: 540  MEKSHLKH----IYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQ 595
             ++ HL +      +KK+ +LQ  L+K K     K+ + EE  KE+ E L    E Q+ +
Sbjct: 3192 TDEVHLLNDTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFSLESQKQR 3247

Query: 596  AQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQ 655
              Q +  LE+ K+ +  + +K+      + +++  D   S+        + L + E +R 
Sbjct: 3248 NLQLNLLLEQQKQLLNESQQKI------ESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3301

Query: 656  RYEQQIVELKLEHEQEKTHLLQQHNAEKDSL-VRDHEREIENLEKQLRAAN---MEHENQ 711
            R     +   L+ E+E    LQ  +    S      E  ++ L+KQL   +   +E  N+
Sbjct: 3302 RE----MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE 3357

Query: 712  IQEFKKRDAQVIADME--AQVHK---LREELINVNSQRKQQLVELGLLREEEKQRATREH 766
             +++K    Q    ME   QVH+     E+  N   Q+K   ++    + E+ QR   E 
Sbjct: 3358 TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ---SKVEDLQRQLEEK 3414

Query: 767  EIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKL--KQIEKEYTQKLAKSSQIIAEL 824
               V KL  E ++++  +++    E E   ++ + ++  + + +  T  L         L
Sbjct: 3415 RQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVL 3474

Query: 825  QTTISSLKEENSQQQL--------AAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELE 876
            Q  I    +E++  +L             L+ +RQK +    +L     +A + LQ E  
Sbjct: 3475 QQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETA 3534

Query: 877  NRSN----QVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQ--ELEDTISSL 930
            +  +    Q    E  LQ ++L  Q+          T    L    LRQ  EL   IS L
Sbjct: 3535 DDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQL 3594

Query: 931  KSQVNFLQKRASILQEELTTYQ 952
              + N L+     L+E++  Y+
Sbjct: 3595 TEEKNDLRNMVMKLEEQIRWYR 3616



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 119/590 (20%), Positives = 236/590 (40%), Gaps = 98/590 (16%)

Query: 249  LSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILE-----------RKNNEIEEL 297
            L  +    L++K K  E     + L  +QK   ++Q  LE           R   E+E+L
Sbjct: 3178 LKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDL 3237

Query: 298  KTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEK 357
            K    S++    +    LE++ Q L    Q I                          ++
Sbjct: 3238 KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES------------------------QR 3273

Query: 358  KLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARV 417
             L++A    EQ +          +Q LLE   VR+ +M         ST    +EL A++
Sbjct: 3274 MLYDAQLSEEQGR-------NLELQVLLESEKVRIREM--------SSTLDRERELHAQL 3318

Query: 418  QQLTGEAEN-SNLQRQKLIQE-KAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQ 475
            Q   G  ++   L  + L++E + +LE  +      L E +  +    + +  +  D + 
Sbjct: 3319 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQV 3378

Query: 476  NMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESEL--QRKQQLRD 533
            + K LQT+ +A+    K+ H L      S +E+L++ + + +QQ+ + +L  QR Q +  
Sbjct: 3379 HRKTLQTEQEANTEGQKKMHEL-----QSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ 3433

Query: 534  QENKFQMEKSHLKH----IYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVT 589
            +  K ++E+   +     +Y+         L   +        K E   + KE    ++ 
Sbjct: 3434 EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG--ETKESNYAKLI 3491

Query: 590  EVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQ 649
            E+        +  LE  +++++  + K+    ++  E+++ +            ++F+W 
Sbjct: 3492 EMNG-GGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETA--------DDEDFIWV 3542

Query: 650  LEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANME-- 707
             E+I    ++ I++L+          L     E+ SLV        +L ++L   N E  
Sbjct: 3543 QENI----DEIILQLQ---------KLTGQQGEEPSLV-SPSTSCGSLTERLLRQNAELT 3588

Query: 708  -HENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQL---VELGLLREEEKQRAT 763
             H +Q+ E K     ++  +E Q+   R+     ++  +  L     +  +   EK+   
Sbjct: 3589 GHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWN 3648

Query: 764  REHEIVVNKLK---AESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEY 810
            RE   +   LK   AE  K+K EL+     +T ++ +  +  LK+I  +Y
Sbjct: 3649 REKLTLQKSLKRAEAEVYKLKAELRNDSLLQT-LSPDSEHVTLKRIYGKY 3697



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 134/725 (18%), Positives = 283/725 (39%), Gaps = 75/725 (10%)

Query: 272  KLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRE 331
            K KL    D +  K+ E    +++EL++L  S Q + +ET +  E ++  L +  Q + E
Sbjct: 1322 KSKLSSLQDLEKTKLEE----QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377

Query: 332  TKEDQIAELKKICEQSTESLNNDWE----KKLHNAVAEME-----QEKFDLQKQHTENIQ 382
            +       +  +    +++    +     KK  +   E       +E+ ++ K   +  Q
Sbjct: 1378 STVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQ 1437

Query: 383  ELLEDTNVRLNKMESEYMAQTQSTNHMI--KELEARVQQLTG--EAENSNLQRQKLIQEK 438
            E LE+   ++    S   AQ    + +   KE  A  +Q     + E       KL Q++
Sbjct: 1438 EQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQ 1497

Query: 439  AELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALS 498
               +    +     +E K     L +    ++        + ++K   D  L   E   S
Sbjct: 1498 IGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESK---DCVLTISEEMFS 1554

Query: 499  ASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQS 558
              K   + + +   +           +  ++QL D   +   +    +   E        
Sbjct: 1555 KDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR 1614

Query: 559  ELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEV--QRLQAQQADAALEEFKRQVELN--- 613
            ++++ +ED +    + +E +K    QL + + +  + L +++    LEE +   +L+   
Sbjct: 1615 QMERQREDQE----QLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAG 1670

Query: 614  SEKVYAEMKEQMEKVEADLTRSKSLREK--QSKEFLWQLEDI------RQRYEQQIVE-- 663
             EK+  E++    + +        + E+  + KE   + ED+       +RY  Q     
Sbjct: 1671 REKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNR 1730

Query: 664  -LKLEHEQEKTHLLQQHN--------AEKDSLVRDHEREIENLEKQLRAANMEHENQIQE 714
             LK+  E  KT    +           ++ S  +     I   E +    +  HE   + 
Sbjct: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790

Query: 715  FKKR-DAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKL 773
              +   +   +DM      +  ++    ++  Q+LV  G    E           + ++L
Sbjct: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850

Query: 774  KAESEKMKIELKKT-----HAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTI 828
            +A  EK+   + +T     HA  T+  L + + + KQ   E T+ L    ++   L    
Sbjct: 1851 QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ---EATESLKCQEELRERLH--- 1904

Query: 829  SSLKEENSQQQLAAE-RRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEK 887
               +E  +++QLA E  + + V   + DEK       ++ I+   D ++    ++ CA  
Sbjct: 1905 ---EESRAREQLAVELSKAEGVIDGYADEKTLF----ERQIQEKTDIIDRLEQELLCASN 1957

Query: 888  KLQHKELESQEQITYIRQEYETKLKGLMPASL----RQELEDTISSLKSQVNFLQKRASI 943
            +LQ  ELE+++Q     +E  ++ K  M A      +Q L++T   +K ++  +Q +A  
Sbjct: 1958 RLQ--ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE-VQCQAEK 2014

Query: 944  LQEEL 948
            ++++L
Sbjct: 2015 VRDDL 2019



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 154/772 (19%), Positives = 291/772 (37%), Gaps = 143/772 (18%)

Query: 292  NEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESL 351
            NE  EL+  YR +  + +E +  L  KV        V++         L KI  Q T+ +
Sbjct: 1237 NEDPELQD-YRYEVQDFQENMHTLLNKVTEEYNKLLVLQ-------TRLSKIWGQQTDGM 1288

Query: 352  NNDWEKK-----------LHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYM 400
              ++ ++           +H+ +  +E    D+   H   +  L +    +L +   E  
Sbjct: 1289 KLEFGEENLPKEETEFLSIHSQMTNLE----DIDVNHKSKLSSLQDLEKTKLEEQVQELE 1344

Query: 401  AQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRN 460
            +   S    +KE E        EAE   LQ++     ++ +     +    + E  A+R 
Sbjct: 1345 SLISSLQQQLKETEQNY-----EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399

Query: 461  -------------TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIE 507
                         T+    +  V +    +KLL+ +Y   +     +  +S S A +   
Sbjct: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT 1459

Query: 508  EL------EQNVCQLKQQ----LQESELQRKQQLRDQENKFQ-MEKSHLKHIYEKKAHDL 556
            EL      ++N    KQ      QE     + +L   +  FQ  E   +K  ++++   L
Sbjct: 1460 ELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVK--FKEEFKPL 1517

Query: 557  QSEL-DKGKED--TQKKIHKFEEA------LKEKEEQLTRVTEVQRLQAQQADAALEEFK 607
              EL + GKE   +    H   E+      + E+     +   V++    +   +  +  
Sbjct: 1518 SKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDAS 1577

Query: 608  RQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLE 667
            RQ+ LN E++    +E + + +     ++ LR+   +    Q+E  RQR +Q+  +L+ E
Sbjct: 1578 RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR----QME--RQREDQE--QLQEE 1629

Query: 668  HEQEKTHLLQQHNAEKDSLVRDHERE-IENLE--KQLRAANME----------------H 708
             ++    L Q+ + + ++LV + ER  +E LE  KQL  A  E                +
Sbjct: 1630 IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689

Query: 709  ENQ----IQEFKKRD---------AQVIADMEAQVHKLREELINVNSQ--RKQQLVE--- 750
            ENQ     Q FK+++          +++++    + K    L+ +  +  +    VE   
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETI 1749

Query: 751  ----LGLLREEEKQRAT------REHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKAN 800
                LG+L    K +++       E E  V     E      +      + ++M     N
Sbjct: 1750 GRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDIN 1809

Query: 801  --SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKK 858
              SK+ +   E +Q+L +S     E+         EN +  L    RLQ   +K  +   
Sbjct: 1810 MWSKVTEEGTELSQRLVRSGFAGTEID-------PENEELMLNISSRLQAAVEKLLEAIS 1862

Query: 859  QLIRDNDQAIKVLQDEL--------ENRSNQVRCAE--KKLQHKELESQEQITYIRQEYE 908
            +     + A KV Q EL        +  +  ++C E  ++  H+E  ++EQ+     + E
Sbjct: 1863 ETSSQLEHA-KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAE 1921

Query: 909  TKLKGLMPASLR-----QELEDTISSLKSQVNFLQKRASILQEELTTYQGRR 955
              + G            QE  D I  L+ ++     R   L+ E    Q  R
Sbjct: 1922 GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEER 1973


>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
          Length = 1060

 Score =  122 bits (307), Expect = 1e-27
 Identities = 164/733 (22%), Positives = 321/733 (43%), Gaps = 122/733 (16%)

Query: 314 KLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDL 373
           K+ KK+  L +    +  T++D+        E S E+L    +++L NAVAE +     L
Sbjct: 37  KMCKKIAQLTKVIYALN-TRQDE-------AEASMEALREAHQEELQNAVAETKARL--L 86

Query: 374 QKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKE-----LEARVQQLTGEAENSN 428
           Q+Q     + LL+    R+  +ES    Q + T   + E     LE + ++L  EAE++ 
Sbjct: 87  QEQGCAEEEALLQ----RIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAE 142

Query: 429 ----LQRQKLIQEKAELERCYQITCS------------------------ELQEVKARRN 460
               L R+ +++ KA+ ER  Q   S                        E+QEV     
Sbjct: 143 RVLTLSRE-MLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQ 201

Query: 461 TLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQL 520
            L  E   L  DY +  + LQ  Y+ +   ++Q    S S+A    +E E ++ +   Q+
Sbjct: 202 RLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDL-RKNFQV 260

Query: 521 QESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKE 580
           QES LQ + +  + + + +  K      Y +K  +   +LD   ++ +++  + +   K+
Sbjct: 261 QESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKK 320

Query: 581 KEEQLTRVTEVQRLQ----AQQADAALEEF-------KRQVELNSEKVYAEMKEQMEKVE 629
             E+L    +   LQ     QQ DA   E        + + +L +  ++ +  +   K  
Sbjct: 321 LGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKEC 380

Query: 630 ADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRD 689
             +     ++ K  KE   + E ++Q+YE+ + ++K + E+EK HL  Q     + LV+ 
Sbjct: 381 PCMKGGTDMQTK--KEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKK 438

Query: 690 HEREIENLEKQLRAANM----EHENQIQEFKKRDAQVIADMEAQVHKLREELIN--VNSQ 743
           H  EI+++   + A       E E Q++E +K+  + I  +E +   L  +L N  +   
Sbjct: 439 HTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVL 498

Query: 744 RKQQLVELGLLR----EEEKQRATREH--------------------EIVVNKLKAES-- 777
           R ++ ++    R    EE  Q   R+H                    E   +KL AE   
Sbjct: 499 RLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT 558

Query: 778 -----EKMKIELKKTHAAETEM--TLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTIS- 829
                E+ K+ LK+    +  +   L++  SK++++E+++  + AK    ++++Q  +  
Sbjct: 559 SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQ 618

Query: 830 ----------SLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRS 879
                     +LK+ +  ++   +R LQ+  Q+    K QL   + +A+++L+   + R 
Sbjct: 619 CTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE---KARH 675

Query: 880 NQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQK 939
            +++  E++L+    ES   +    Q +  +L+ L     RQEL++    +++Q   L +
Sbjct: 676 QELKATEERLKK---ESSHSLQIQHQTHRLELQAL-EEKARQELQEERERMQAQQALLLE 731

Query: 940 RASILQEELTTYQ 952
               L++EL+  Q
Sbjct: 732 S---LRQELSEQQ 741



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 151/779 (19%), Positives = 308/779 (39%), Gaps = 103/779 (13%)

Query: 237 LRKSSSFHDDHFLSRIREKELDMK---TKMMEAKFHEEKLKLQQKHDADVQ-KILERKNN 292
           LRK+    +    +++R+ E D++    K+ + K + +KLK ++  D DVQ K   ++N+
Sbjct: 254 LRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLK-ERIQDLDVQLKEARQENS 312

Query: 293 EIEE-----------------LKTLYRSKQHETEETIRKLEKKV---------------- 319
           E++                  L+    ++Q +  +T    E KV                
Sbjct: 313 ELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQ 372

Query: 320 -QTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKF------- 371
            Q+ +++C  ++   + Q    KK     TE +   +E+ L     + E+EK        
Sbjct: 373 DQSCLKECPCMKGGTDMQT---KKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLV 429

Query: 372 ----DLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENS 427
               DL K+HT  I+ +         K++ E  AQ +      K+ E  ++QL  E    
Sbjct: 430 KRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVR---KKSEKEIKQLEEEKAAL 486

Query: 428 NLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDAD 487
           N++ Q  + E   LE   Q   +     +     L ++   ++   +  +KL +T    +
Sbjct: 487 NVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGE 546

Query: 488 INLLKQEHALSASKASSMIEELEQNVC---------QLKQQLQE--SELQR-KQQLRDQE 535
               + +  L+A + +S  EE    V           L   L+E  S++QR ++  + Q+
Sbjct: 547 ----EYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQK 602

Query: 536 NKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQ 595
            K Q + S ++   E+   + + +L   K+ +  +  K +  L+E  +Q   +       
Sbjct: 603 AKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEAS 662

Query: 596 AQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQ 655
            Q+A   LE+ + Q          E+K   E+++ + + S  ++ +  +  L  LE+  +
Sbjct: 663 HQRALRMLEKARHQ----------ELKATEERLKKESSHSLQIQHQTHRLELQALEEKAR 712

Query: 656 RYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEF 715
           +  Q+  E     +      L+Q  +E+ +    H++++E L+ +LRA   +  +     
Sbjct: 713 QELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPG 772

Query: 716 KKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREE-EKQRATREHEIVVNKLK 774
             +D  +IA  E               Q   +    GL  E  + Q A R     V + +
Sbjct: 773 DSKD-HIIATEERGGPGQAGSPPGAAGQGSGE--GCGLWEENAQLQDAVRRLRAEVEQHQ 829

Query: 775 AESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEE 834
            E++K++ + +     +      +  +  ++  KE    +A  S   A+LQ  +++L+ E
Sbjct: 830 QEAQKLRDQRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAE 889

Query: 835 NSQQQLAAERRLQDVRQKFEDEKKQLIRDND-QAIKVLQDELENRSNQVR--CAEKKLQH 891
                         ++   E   K   R  D Q I  LQ  L+ R + ++    E++  +
Sbjct: 890 --------------LKDSGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHY 935

Query: 892 KELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTT 950
               S          +      L P+  ++++ED  S + S  N      + L  +L++
Sbjct: 936 AAFPSAMSHRNRSFSFNPHPGYLTPSMKKKKVEDVPSRVVSVPNLASYAKNFLSGDLSS 994


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score =  122 bits (307), Expect = 1e-27
 Identities = 165/746 (22%), Positives = 310/746 (41%), Gaps = 127/746 (17%)

Query: 237 LRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKN----N 292
           L K+ SF+         E+ELD  T      F  E L+  ++ +AD++K  + +      
Sbjct: 132 LNKAQSFY---------ERELD--TLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180

Query: 293 EIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLN 352
            I +LKT  +  Q E    + K +K +QT +   +   +  + Q+ + K+  E +  S +
Sbjct: 181 TIGKLKTELQMVQDEAGSLLDKCQK-LQTALAIAENNVQVLQKQLDDAKE-GEMALLSKH 238

Query: 353 NDWEKKLHNAVAEMEQEKFDL--QKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMI 410
            + E +L  A   ++Q+  DL  +  H   +Q       V +  +ESE     +  + + 
Sbjct: 239 KEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLE 298

Query: 411 KE---LEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKD 467
           +E   L ++ Q L  E +   L+ +K + E    ++ Y                      
Sbjct: 299 EERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEY---------------------- 336

Query: 468 HLVNDYEQNMKLLQTKYDADINLLKQEHALS----ASKASSMIEELEQNVCQLKQQLQ-- 521
                YE+ +K LQ++ + ++  L + H+ +    A K    IE +  N  + K++LQ  
Sbjct: 337 -----YERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD 391

Query: 522 --ESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALK 579
             E   + K  L + +N+ Q E  +LK + E K +    E+       Q  + K E+ L 
Sbjct: 392 LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGH----LQDMVRKSEQGLG 447

Query: 580 EKEEQLTRVTEVQRLQAQQADAALEEFKRQVE--LNSEKVYAEMKEQMEKVEADLTRSKS 637
             E  +  + + Q     + D   +  K   +  LN E    + ++Q E+  A +   + 
Sbjct: 448 SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEK 507

Query: 638 LREKQSK---EFLWQLEDIRQRYEQQIVELKLEHEQEK----THLLQQHNAEKDSLVRDH 690
           L+  +     E  W  E++RQ   +   EL+L+HE++K    + LLQ  + EK++     
Sbjct: 508 LKVDKMAHDLEIKWT-ENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSW 566

Query: 691 EREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVE 750
           ++++E+L  Q+       E Q+                             SQ +  L +
Sbjct: 567 QKKVEDLLNQISLLKQNLEIQL-----------------------------SQSQTSLQQ 597

Query: 751 LGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEY 810
           L     +E+QR T+E E    +L+ + ++    LK+ H    +   E+   + + +E   
Sbjct: 598 LQAQFTQERQRLTQELE----ELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 653

Query: 811 TQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKV 870
            QK +      AELQ+   + +E     ++  E+ LQ +R + EDE K ++         
Sbjct: 654 QQKHS------AELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLAS------- 700

Query: 871 LQDELENRSNQVRCAEKKLQHKEL-----ESQEQITYIRQEYETKLKGLMPASLRQEL-- 923
           L+ EL ++        +   H+EL     E +  I   R++ +  +  +    L++EL  
Sbjct: 701 LRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRI--TDLQEELRH 758

Query: 924 -EDTISSLKSQVNFLQKRASILQEEL 948
            E  IS L  +V  L +  S L +EL
Sbjct: 759 REHHISELDKEVQHLHENISALTKEL 784



 Score =  112 bits (279), Expect = 2e-24
 Identities = 133/651 (20%), Positives = 300/651 (46%), Gaps = 66/651 (10%)

Query: 249 LSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHET 308
           LS+ +E E ++       +     L L+  H   +Q     +   I++L+    S++   
Sbjct: 235 LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLE----SEKSRV 290

Query: 309 EETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQ 368
            E + +LE++   L    Q + E ++ QI EL+K   ++  +    +E++L N  + +E+
Sbjct: 291 NERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEE 350

Query: 369 EKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSN 428
           E   L + H++ ++EL    ++ +  + S  +   +     ++E +    +L  E + + 
Sbjct: 351 EVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE-QHNKDKLNLEEDKNQ 409

Query: 429 LQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADI 488
           LQ+        ELE   ++       ++ + NT ++E  HL +   ++ + L +      
Sbjct: 410 LQQ--------ELENLKEV-------LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIA 454

Query: 489 NLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHI 548
           +L   +  L      + ++  + ++ + K  L   E + +Q+ +  E      K   K  
Sbjct: 455 SLQDSQERL-----QNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLK 509

Query: 549 YEKKAHDLQSELDKGKEDTQKKIHKFEEALK--EKEEQLTRVTEVQRLQAQQADAALEEF 606
            +K AHDL+    K  E+ +++  K  E L+   +E++ + ++++ +L+ ++ +AA + +
Sbjct: 510 VDKMAHDLEI---KWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSW 566

Query: 607 KRQVE--LNSEKVYAEMKE-QMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVE 663
           +++VE  LN   +  +  E Q+ + +  L + ++   ++ +    +LE++ ++++Q+   
Sbjct: 567 QKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKS 626

Query: 664 LK---------LEHEQEK------THLLQQHNAEKDSLVRDHEREIE----NLEKQLRAA 704
           LK         +E E+EK       HL Q+H+AE  SL   H   +E     +E++L+  
Sbjct: 627 LKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTL 686

Query: 705 NMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLRE-EEKQRAT 763
             E E+   E K   A + +++  Q H    +L+  N  ++    ++ L R  +  +R +
Sbjct: 687 RFELED---EGKAMLASLRSELNHQ-HAAAIDLLRHNHHQELAAAKMELERSIDISRRQS 742

Query: 764 REHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAE 823
           +EH   +  L+ E     +  ++ H +E +  ++  +  +  + KE   K  +  +I +E
Sbjct: 743 KEHICRITDLQEE-----LRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE 797

Query: 824 LQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDE 874
               I    EE  ++ L  E + +D+  +   E K ++ + DQ IK L ++
Sbjct: 798 SNQQIR--LEEMEEKYLMRESKPEDI--QMITELKAMLTERDQIIKKLIED 844



 Score =  110 bits (274), Expect = 8e-24
 Identities = 168/744 (22%), Positives = 315/744 (42%), Gaps = 143/744 (19%)

Query: 295 EELKTLYRSKQHETEETIRKLE----KKVQTLIRDCQVIRETKEDQIAELKKICEQSTES 350
           ++  T + + +H  E+     E    +++ T+ R+ + IR   E+++        +S   
Sbjct: 3   QQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKL--------RSFGQ 54

Query: 351 LNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELL---EDTNVRLN----KMESEYMAQT 403
           L   +EK    A+        DLQ  H   IQELL   +D +  +N    K E  +  + 
Sbjct: 55  LQVQFEKDKRLALE-------DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEV 107

Query: 404 QSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAE-LERCYQITCSELQEVKARRNTL 462
           +S N M++EL    ++L  + E    + Q   + + + L+R    T   LQ  K +   L
Sbjct: 108 ESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADL 167

Query: 463 HKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL---EQNVCQLKQQ 519
            KE        E  ++    K   ++ +++ E      K   +   L   E NV  L++Q
Sbjct: 168 RKE----FQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQ 223

Query: 520 LQ----------------ESEL-QRKQQLRDQENKFQMEKSHL------KHIYEKKAHDL 556
           L                 ESEL   +++L+ Q +   ++ SH+      +   E    DL
Sbjct: 224 LDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDL 283

Query: 557 QSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEK 616
           +SE    K    +++ + EE       +   + E Q+ Q  + +  + E KR  +   E+
Sbjct: 284 ESE----KSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYER 339

Query: 617 VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLL 676
              E+K    ++E ++T+      K  +E  W+     +      +  K + + +   L 
Sbjct: 340 ---ELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD---LE 393

Query: 677 QQHNAEKDSLVRDH---EREIEN----LEKQLRAANMEHENQIQEFKKRDAQ-------V 722
           +QHN +K +L  D    ++E+EN    LE +L  AN E    +Q+  ++  Q       +
Sbjct: 394 EQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQE-IGHLQDMVRKSEQGLGSAEGL 452

Query: 723 IADMEAQVHKLREE--------------LINV----NSQRKQQLVELGLLREEEKQRATR 764
           IA ++    +L+ E              L+NV      +R+Q    +  ++EEEK +  +
Sbjct: 453 IASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDK 512

Query: 765 -EHEIVV---NKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSS-- 818
             H++ +     L+ E  K++ EL+  H    E   + A S+L Q+ K+  +  A+ S  
Sbjct: 513 MAHDLEIKWTENLRQECSKLREELRLQH----EEDKKSAMSQLLQL-KDREKNAARDSWQ 567

Query: 819 QIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQA----------- 867
           + + +L   IS LK+    Q   ++  LQ ++ +F  E+++L ++ ++            
Sbjct: 568 KKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSL 627

Query: 868 ----IKVLQDELENRSNQVRCAEKKLQHK---ELES-----QEQITYIRQEYETKLKGLM 915
               +   Q   E +  + R  E  LQ K   EL+S     +E +   R E E +L+   
Sbjct: 628 KEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQ--- 684

Query: 916 PASLRQELED----TISSLKSQVN 935
             +LR ELED     ++SL+S++N
Sbjct: 685 --TLRFELEDEGKAMLASLRSELN 706



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 124/565 (21%), Positives = 237/565 (41%), Gaps = 102/565 (18%)

Query: 436 QEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEH 495
           QEKAE     ++   E++ +      L  E+  L+ DYE  +   Q+ Y+ +++ LK+  
Sbjct: 96  QEKAE-----ELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQ 150

Query: 496 ALSASKASSMIEE--------------LEQNVCQLKQQLQESELQRKQQLRDQENKFQME 541
             +A    +  E+              L + + +LK +LQ  +      L D+  K Q  
Sbjct: 151 LFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQ-DEAGSLLDKCQKLQTA 209

Query: 542 KSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADA 601
            +    I E     LQ +LD  KE     + K     KE E +L    E  RLQ Q +D 
Sbjct: 210 LA----IAENNVQVLQKQLDDAKEGEMALLSKH----KEVESELAAARE--RLQQQASDL 259

Query: 602 ALEE----FKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRY 657
            L+       +  ++  E    +++ +  +V                E L QLE+ R   
Sbjct: 260 VLKASHIGMLQATQMTQEVTIKDLESEKSRVN---------------ERLSQLEEERAFL 304

Query: 658 EQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKK 717
             +   L  E +Q+   L ++ N  K +    +ERE++NL+ +L       E ++ +  +
Sbjct: 305 RSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRL-------EEEVTQLNE 357

Query: 718 RDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAES 777
             ++ + ++ A  H +  E ++ N+ R ++ +++ L  +  K +   E +   N+L+ E 
Sbjct: 358 AHSKTLEEL-AWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEED--KNQLQQEL 414

Query: 778 EKMKIELK-KTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK---- 832
           E +K  L+ K + A  E+        L+ + ++  Q L  +  +IA LQ +   L+    
Sbjct: 415 ENLKEVLEDKLNTANQEI------GHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELD 468

Query: 833 ------EENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELE---NRSNQVR 883
                 +E     L  E  L+  RQ+ E+    +  +    +  +  +LE     + +  
Sbjct: 469 LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQE 528

Query: 884 CA----EKKLQHKE-----------LESQEQITYIRQEYETKLKGLMP--ASLRQELEDT 926
           C+    E +LQH+E           L+ +E+    R  ++ K++ L+   + L+Q LE  
Sbjct: 529 CSKLREELRLQHEEDKKSAMSQLLQLKDREK-NAARDSWQKKVEDLLNQISLLKQNLEIQ 587

Query: 927 ISSLKS-----QVNFLQKRASILQE 946
           +S  ++     Q  F Q+R  + QE
Sbjct: 588 LSQSQTSLQQLQAQFTQERQRLTQE 612



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 93/470 (19%), Positives = 205/470 (43%), Gaps = 54/470 (11%)

Query: 517 KQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEE 576
           +Q L E E  +    R ++ +   E  H++ I       +  E+++ +   ++K+  F +
Sbjct: 3   QQALTEFEAYKH---RVEDMQLCAEAQHVQRIVT-----MSREVEEIRRKFEEKLRSFGQ 54

Query: 577 AL----KEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADL 632
                 K+K   L  +    R + Q+   + ++    V    EK     + ++E +   L
Sbjct: 55  LQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKML 114

Query: 633 TRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK---------LEHEQEKTHLLQQHNAEK 683
              +  R+K  +++  +L   +  YE+++  LK         L+  +EK   L++    +
Sbjct: 115 EELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQ 174

Query: 684 DSLVRDHEREIENLEKQLRAANMEHENQIQEFKK-RDAQVIAD-----MEAQVHKLREEL 737
           ++++R   + I  L+ +L+    E  + + + +K + A  IA+     ++ Q+   +E  
Sbjct: 175 EAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGE 231

Query: 738 INVNSQRKQQLVELGLLREEEKQRATREHEIV-----VNKLKAESEKMKIELKKTHAAET 792
           + + S+ K+   EL   RE  +Q+A+   ++V     +  L+A     ++ +K     + 
Sbjct: 232 MALLSKHKEVESELAAARERLQQQAS---DLVLKASHIGMLQATQMTQEVTIK-----DL 283

Query: 793 EMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLK----EENSQQQLAAERRLQD 848
           E    + N +L Q+E+E     +K+  +  E +  I  L+    E    QQ   ER L++
Sbjct: 284 ESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKN 343

Query: 849 VRQKFEDEKKQLIRDNDQAIKVLQDELEN-----RSNQVRCAEKKLQHKELESQEQITYI 903
           ++ + E+E  QL   + + ++ L  +         SN +R  +KK    +LE Q     +
Sbjct: 344 LQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIR--DKKKLQMDLEEQHNKDKL 401

Query: 904 RQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQG 953
             E +         +L++ LED +++   ++  LQ      ++ L + +G
Sbjct: 402 NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 451


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.336 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,958,330
Number of Sequences: 37866
Number of extensions: 1673501
Number of successful extensions: 27624
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 444
Number of HSP's successfully gapped in prelim test: 1602
Number of HSP's that attempted gapping in prelim test: 8497
Number of HSP's gapped (non-prelim): 8605
length of query: 955
length of database: 18,247,518
effective HSP length: 112
effective length of query: 843
effective length of database: 14,006,526
effective search space: 11807501418
effective search space used: 11807501418
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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