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Search of human proteins with 7705939
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
(456 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 914 0.0
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 385 e-107
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 385 e-107
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 350 2e-96
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 262 5e-70
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 262 5e-70
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 262 5e-70
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 159 6e-39
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 145 7e-35
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 93 6e-19
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 93 6e-19
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 92 1e-18
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 90 4e-18
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 90 4e-18
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 87 2e-17
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 87 2e-17
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 87 2e-17
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 84 3e-16
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 84 3e-16
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 80 3e-15
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 80 4e-15
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 80 5e-15
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 75 1e-13
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 75 1e-13
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 75 1e-13
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 73 5e-13
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 70 5e-12
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 70 5e-12
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 68 2e-11
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 68 2e-11
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 914 bits (2363), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTL 60
MEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTL
Sbjct: 1 MEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTL 60
Query: 61 RLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHS 120
RLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHS
Sbjct: 61 RLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHS 120
Query: 121 YVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTA 180
YVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTA
Sbjct: 121 YVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTA 180
Query: 181 LGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHEL 240
LGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHEL
Sbjct: 181 LGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHEL 240
Query: 241 EFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALC 300
EFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALC
Sbjct: 241 EFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALC 300
Query: 301 KQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVIS 360
KQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVIS
Sbjct: 301 KQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVIS 360
Query: 361 KMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDME 420
KMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDME
Sbjct: 361 KMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDME 420
Query: 421 ASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ 456
ASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
Sbjct: 421 ASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ 456
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 385 bits (989), Expect = e-107
Identities = 196/448 (43%), Positives = 289/448 (64%), Gaps = 13/448 (2%)
Query: 7 LGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLV 66
L K+ + ++L + Y LLQE++ + +++ Y+ + D + L+E L ++V
Sbjct: 427 LNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIV 486
Query: 67 ETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRS 126
+ +I E+ + P K+ K L + F D Q R RGSDE+ +VY DH+Y TIR
Sbjct: 487 K----QISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRV 542
Query: 127 RLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSH 186
++ SV++++ +V +KL G + LI+V +SS GEKV+L+P + VFT L IN
Sbjct: 543 PVATSVKEVISAVADKL-------GSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGR 595
Query: 187 LFACTRDSYEALVPLPEEIQVSPGDT-EIHRVEPEDVANHLTAFHWELFRCVHELEFVDY 245
LFAC R+ +++L PLPE+ + G + +D+A +T + WELF CVHELE + +
Sbjct: 596 LFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYH 655
Query: 246 VFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQD 305
F ++ TANL+L L+R +E+ WV TE+ LC KR QLLKKFIKIAA CK+ ++
Sbjct: 656 TFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKN 715
Query: 306 LLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPP 365
L SF+A+VMGL N AVSRL LTWEKLP KFK + +FE+L DP RNH++YR ++K++PP
Sbjct: 716 LNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPP 775
Query: 366 VIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLD-MEASPN 424
+IPF+PL++KD+TF HEG+KT +D LVN EK+ +A RT+R YRS+P D +A+ N
Sbjct: 776 LIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKN 835
Query: 425 HLQTKAYVRQFQVIDNQNLLFELSYKLE 452
H ++YVRQ VIDNQ L ++S++LE
Sbjct: 836 HQDVRSYVRQLNVIDNQRTLSQMSHRLE 863
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 385 bits (989), Expect = e-107
Identities = 196/448 (43%), Positives = 289/448 (64%), Gaps = 13/448 (2%)
Query: 7 LGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLV 66
L K+ + ++L + Y LLQE++ + +++ Y+ + D + L+E L ++V
Sbjct: 571 LNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIV 630
Query: 67 ETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRS 126
+ +I E+ + P K+ K L + F D Q R RGSDE+ +VY DH+Y TIR
Sbjct: 631 K----QISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRV 686
Query: 127 RLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSH 186
++ SV++++ +V +KL G + LI+V +SS GEKV+L+P + VFT L IN
Sbjct: 687 PVATSVKEVISAVADKL-------GSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGR 739
Query: 187 LFACTRDSYEALVPLPEEIQVSPGDT-EIHRVEPEDVANHLTAFHWELFRCVHELEFVDY 245
LFAC R+ +++L PLPE+ + G + +D+A +T + WELF CVHELE + +
Sbjct: 740 LFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYH 799
Query: 246 VFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQD 305
F ++ TANL+L L+R +E+ WV TE+ LC KR QLLKKFIKIAA CK+ ++
Sbjct: 800 TFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKN 859
Query: 306 LLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPP 365
L SF+A+VMGL N AVSRL LTWEKLP KFK + +FE+L DP RNH++YR ++K++PP
Sbjct: 860 LNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPP 919
Query: 366 VIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLD-MEASPN 424
+IPF+PL++KD+TF HEG+KT +D LVN EK+ +A RT+R YRS+P D +A+ N
Sbjct: 920 LIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKN 979
Query: 425 HLQTKAYVRQFQVIDNQNLLFELSYKLE 452
H ++YVRQ VIDNQ L ++S++LE
Sbjct: 980 HQDVRSYVRQLNVIDNQRTLSQMSHRLE 1007
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 350 bits (898), Expect = 2e-96
Identities = 191/445 (42%), Positives = 275/445 (61%), Gaps = 11/445 (2%)
Query: 9 RKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVET 68
RK+ L ++ ++ Y+ L E+E + +K +Y ++ D Y L ++ L+ Q +
Sbjct: 293 RKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKE-LKEFQKILG 351
Query: 69 VELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRL 128
+ + + P K+ K LF F ++ LQ R ++EIFC VY+ +HSYV++++++
Sbjct: 352 MHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKV 411
Query: 129 SASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLF 188
S+ Q+IL V EK+QY+EE L LVA++ SGEK LQP + + +L + ++
Sbjct: 412 SSIAQEILKVVAEKIQYAEE------DLALVAITFSGEKHELQPNDLVISKSLEASGRIY 465
Query: 189 ACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFH 248
+D + L P E + I + D+A L F W LF +HE E + + F
Sbjct: 466 VYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFS 525
Query: 249 GERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLS 308
+ TANL LLLQRC+EV WVATE+LLC GKR QL+KKFIKIAA CK ++L S
Sbjct: 526 RQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNS 585
Query: 309 FYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIP 368
F+A+VMGL+ A+VSRL TWEK+PGKFK LF + E+LTDP NHK+YR+ KMKPP IP
Sbjct: 586 FFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIP 645
Query: 369 FVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASP-NHLQ 427
F+PL+LKD+TF+HEG+KT +D LVN EKLH +A+ VRT+R R+ + SP H +
Sbjct: 646 FMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQF---GDLSPKEHQE 702
Query: 428 TKAYVRQFQVIDNQNLLFELSYKLE 452
K+YV VID+Q LFELS+++E
Sbjct: 703 LKSYVNHLYVIDSQQALFELSHRIE 727
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 262 bits (669), Expect = 5e-70
Identities = 166/475 (34%), Positives = 259/475 (54%), Gaps = 44/475 (9%)
Query: 9 RKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLRE---DTLRLHQL 65
++Q L ++ ++ Y +L + A ++ L L+ +D L LRE + R H+L
Sbjct: 419 KRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRL 478
Query: 66 VETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQ-TRVAFRGSDEIFCRVYMPDHSYVTI 124
N P + + L D L + A + D++ + PDHS +T+
Sbjct: 479 ENGCG------NASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTL 532
Query: 125 RSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGIN 184
+ ++ASV++++ ++ ++ G +LV V+S+G+ + LQP V T+LG+N
Sbjct: 533 QLPVTASVREVMAALAQE-------DGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLN 585
Query: 185 SHLFACTRDSYEALVPLPEEIQVSPGDTE-IHRVEPEDVANHLTAFHWELFRCVHELEFV 243
LF L+P P+++ + G E + V +D+A LT W LF +H++E +
Sbjct: 586 ERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELI 645
Query: 244 DYVFHGERGRR-ETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQ 302
YV + R TANLE ++R +E+ +WVATE+ LC PG RAQLL+KFIK+AA K+
Sbjct: 646 HYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKE 705
Query: 303 NQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKM 362
++L SF+AV+ GL N+A+SRL TWE+LP K + L+ E L DP NH+ YR ++K+
Sbjct: 706 QKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKL 765
Query: 363 KPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRS-RPLCLD-ME 420
PPVIPF+PL+LKD+TF+HEG+ TLV+ L+N EK+ +A R + RS P+ L +
Sbjct: 766 SPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLR 825
Query: 421 ASPNHL-----------------------QTKAYVRQFQVIDNQNLLFELSYKLE 452
+ +HL T AYV+Q +VIDNQ L LS +LE
Sbjct: 826 SRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 880
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 262 bits (669), Expect = 5e-70
Identities = 166/475 (34%), Positives = 259/475 (54%), Gaps = 44/475 (9%)
Query: 9 RKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLRE---DTLRLHQL 65
++Q L ++ ++ Y +L + A ++ L L+ +D L LRE + R H+L
Sbjct: 419 KRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRL 478
Query: 66 VETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQ-TRVAFRGSDEIFCRVYMPDHSYVTI 124
N P + + L D L + A + D++ + PDHS +T+
Sbjct: 479 ENGCG------NASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTL 532
Query: 125 RSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGIN 184
+ ++ASV++++ ++ ++ G +LV V+S+G+ + LQP V T+LG+N
Sbjct: 533 QLPVTASVREVMAALAQE-------DGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLN 585
Query: 185 SHLFACTRDSYEALVPLPEEIQVSPGDTE-IHRVEPEDVANHLTAFHWELFRCVHELEFV 243
LF L+P P+++ + G E + V +D+A LT W LF +H++E +
Sbjct: 586 ERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELI 645
Query: 244 DYVFHGERGRR-ETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQ 302
YV + R TANLE ++R +E+ +WVATE+ LC PG RAQLL+KFIK+AA K+
Sbjct: 646 HYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKE 705
Query: 303 NQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKM 362
++L SF+AV+ GL N+A+SRL TWE+LP K + L+ E L DP NH+ YR ++K+
Sbjct: 706 QKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKL 765
Query: 363 KPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRS-RPLCLD-ME 420
PPVIPF+PL+LKD+TF+HEG+ TLV+ L+N EK+ +A R + RS P+ L +
Sbjct: 766 SPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLR 825
Query: 421 ASPNHL-----------------------QTKAYVRQFQVIDNQNLLFELSYKLE 452
+ +HL T AYV+Q +VIDNQ L LS +LE
Sbjct: 826 SRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 880
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 262 bits (669), Expect = 5e-70
Identities = 166/475 (34%), Positives = 259/475 (54%), Gaps = 44/475 (9%)
Query: 9 RKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLRE---DTLRLHQL 65
++Q L ++ ++ Y +L + A ++ L L+ +D L LRE + R H+L
Sbjct: 461 KRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRL 520
Query: 66 VETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQ-TRVAFRGSDEIFCRVYMPDHSYVTI 124
N P + + L D L + A + D++ + PDHS +T+
Sbjct: 521 ENGCG------NASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTL 574
Query: 125 RSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGIN 184
+ ++ASV++++ ++ ++ G +LV V+S+G+ + LQP V T+LG+N
Sbjct: 575 QLPVTASVREVMAALAQE-------DGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLN 627
Query: 185 SHLFACTRDSYEALVPLPEEIQVSPGDTE-IHRVEPEDVANHLTAFHWELFRCVHELEFV 243
LF L+P P+++ + G E + V +D+A LT W LF +H++E +
Sbjct: 628 ERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELI 687
Query: 244 DYVFHGERGRR-ETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQ 302
YV + R TANLE ++R +E+ +WVATE+ LC PG RAQLL+KFIK+AA K+
Sbjct: 688 HYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKE 747
Query: 303 NQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKM 362
++L SF+AV+ GL N+A+SRL TWE+LP K + L+ E L DP NH+ YR ++K+
Sbjct: 748 QKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKL 807
Query: 363 KPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRS-RPLCLD-ME 420
PPVIPF+PL+LKD+TF+HEG+ TLV+ L+N EK+ +A R + RS P+ L +
Sbjct: 808 SPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLR 867
Query: 421 ASPNHL-----------------------QTKAYVRQFQVIDNQNLLFELSYKLE 452
+ +HL T AYV+Q +VIDNQ L LS +LE
Sbjct: 868 SRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 922
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 159 bits (401), Expect = 6e-39
Identities = 82/194 (42%), Positives = 128/194 (65%), Gaps = 3/194 (1%)
Query: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
+VA L+ ++ELFR + E++D +F R + ANL+ + ++ T WVA+E+L
Sbjct: 720 EVATQLSMRNFELFRNIEPTEYIDDLFK-LRSKTSCANLKRFEEVINQETFWVASEILRE 778
Query: 281 EAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFR 340
KR +++K FIKIA C++ ++ S +A++ GL+ A V+RLR TWEKLP K++ LF+
Sbjct: 779 TNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQ 838
Query: 341 KFENLTDPCRNHKSYREVIS--KMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLH 398
++L DP RN YR V++ ++PP+IP P+I KDLTFLHEG+ + VDGLVN EKL
Sbjct: 839 DLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLR 898
Query: 399 SVAEKVRTIRKYRS 412
+A+++R + + S
Sbjct: 899 MIAKEIRHVGRMAS 912
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 145 bits (366), Expect = 7e-35
Identities = 90/272 (33%), Positives = 151/272 (55%), Gaps = 14/272 (5%)
Query: 151 GREDSLILVAVSSSGEKVLLQPTEDCVFTALG----INSHLFACTRDSYEALVPLPEEIQ 206
G D+ L VS + E V+ Q F+ L +N + E L E+ Q
Sbjct: 788 GASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCS-DEDAQ 846
Query: 207 --VSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVF--HGERGRRETANLELL 262
V + ++ +VA L+ ++LFR + E++D +F + + G E +
Sbjct: 847 ELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDI 906
Query: 263 LQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVS 322
+ ++ T WVA+E+L KR +++K FIKIA C++ ++ S +A++ GL+ A+V+
Sbjct: 907 V---NQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVA 963
Query: 323 RLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVIS--KMKPPVIPFVPLILKDLTFL 380
RLR TWEKLP K++ + +++ DP RN YR ++S M+PP+IP P++ KD+TFL
Sbjct: 964 RLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1023
Query: 381 HEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRS 412
HEG+ + VDGLVN EKL +++++R + + S
Sbjct: 1024 HEGNDSKVDGLVNFEKLRMISKEIRQVVRMTS 1055
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 92.8 bits (229), Expect = 6e-19
Identities = 55/183 (30%), Positives = 99/183 (54%), Gaps = 7/183 (3%)
Query: 214 IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWV 273
+H ++A LT ELF + E + ++ E+ ++ NL + + +++WV
Sbjct: 854 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWV 911
Query: 274 ATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPG 333
+ ++L E R +LL KFIKI ++ + S+ A++ LD+A + RL W+K
Sbjct: 912 RSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTS 969
Query: 334 KFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVN 393
+ ++ L D + ++YR +S+++PP IP++ LIL+DLTF+H G+ +DG VN
Sbjct: 970 EG---LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVN 1026
Query: 394 IEK 396
K
Sbjct: 1027 FSK 1029
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 92.8 bits (229), Expect = 6e-19
Identities = 55/183 (30%), Positives = 99/183 (54%), Gaps = 7/183 (3%)
Query: 214 IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWV 273
+H ++A LT ELF + E + ++ E+ ++ NL + + +++WV
Sbjct: 836 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWV 893
Query: 274 ATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPG 333
+ ++L E R +LL KFIKI ++ + S+ A++ LD+A + RL W+K
Sbjct: 894 RSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTS 951
Query: 334 KFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVN 393
+ ++ L D + ++YR +S+++PP IP++ LIL+DLTF+H G+ +DG VN
Sbjct: 952 EG---LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVN 1008
Query: 394 IEK 396
K
Sbjct: 1009 FSK 1011
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 91.7 bits (226), Expect = 1e-18
Identities = 54/233 (23%), Positives = 113/233 (48%), Gaps = 6/233 (2%)
Query: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
++A +T +FR + EF+ + T + Q +++++ VA++++
Sbjct: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
Query: 281 EAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFR 340
RA ++K++ +A +C+ + + L+ +A+ RL+ TW K+ + K L
Sbjct: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
Query: 341 KFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLV-DGLVNIEKLHS 399
K + K+ RE + PP +P++ + L DL F+ EG+ +GLVN K+
Sbjct: 1125 KLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRM 1184
Query: 400 VAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
++ +R IR+++ +D + + Y+ +I +++ L+ELS K+E
Sbjct: 1185 ISHIIREIRQFQQTSYRIDHQP-----KVAQYLLDKDLIIDEDTLYELSLKIE 1232
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 90.1 bits (222), Expect = 4e-18
Identities = 63/237 (26%), Positives = 117/237 (49%), Gaps = 7/237 (2%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+EPE+++ HLT ++ FR + ++ +Y+ + +E +E + C+ ++ WV
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQNYLVNS--CVKENPTMERSIALCNGISQWVQLM 261
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
VL P RA++ KFI++A Q Q+ + AV+ GL ++++SRL+ T +P +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKT-LVDGLVNIE 395
+ + L RN+ +YR + IP + + LKDL L+E L DG VN+
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 396 KLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
KL ++ + + + + L+ HL T + + ++ ++ELSY E
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLS----LDLYYTEDEIYELSYARE 434
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 90.1 bits (222), Expect = 4e-18
Identities = 63/237 (26%), Positives = 117/237 (49%), Gaps = 7/237 (2%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+EPE+++ HLT ++ FR + ++ +Y+ + +E +E + C+ ++ WV
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQNYLVNS--CVKENPTMERSIALCNGISQWVQLM 261
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
VL P RA++ KFI++A Q Q+ + AV+ GL ++++SRL+ T +P +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKT-LVDGLVNIE 395
+ + L RN+ +YR + IP + + LKDL L+E L DG VN+
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 396 KLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
KL ++ + + + + L+ HL T + + ++ ++ELSY E
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLS----LDLYYTEDEIYELSYARE 434
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 87.4 bits (215), Expect = 2e-17
Identities = 54/233 (23%), Positives = 115/233 (49%), Gaps = 6/233 (2%)
Query: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
++A LT +F+ + EF + T + + +++++ +A+E++
Sbjct: 1025 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1084
Query: 281 EAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFR 340
E R ++K++ +A +C+ + + + ++ +A+ RL+ TW K+ + K L
Sbjct: 1085 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1144
Query: 341 KFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLV-DGLVNIEKLHS 399
K + L K+ RE + PP +P++ + L DL F+ EG+ DGLVN K+
Sbjct: 1145 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1204
Query: 400 VAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
++ +R IR+++ ++ +A T+ + Q V+D ++ L+E S ++E
Sbjct: 1205 ISHIIREIRQFQQTAYKIEHQAK----VTQYLLDQSFVMDEES-LYESSLRIE 1252
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 87.4 bits (215), Expect = 2e-17
Identities = 54/233 (23%), Positives = 115/233 (49%), Gaps = 6/233 (2%)
Query: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
++A LT +F+ + EF + T + + +++++ +A+E++
Sbjct: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
Query: 281 EAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFR 340
E R ++K++ +A +C+ + + + ++ +A+ RL+ TW K+ + K L
Sbjct: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
Query: 341 KFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLV-DGLVNIEKLHS 399
K + L K+ RE + PP +P++ + L DL F+ EG+ DGLVN K+
Sbjct: 1161 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1220
Query: 400 VAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
++ +R IR+++ ++ +A T+ + Q V+D ++ L+E S ++E
Sbjct: 1221 ISHIIREIRQFQQTAYKIEHQAK----VTQYLLDQSFVMDEES-LYESSLRIE 1268
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 87.4 bits (215), Expect = 2e-17
Identities = 54/233 (23%), Positives = 115/233 (49%), Gaps = 6/233 (2%)
Query: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
++A LT +F+ + EF + T + + +++++ +A+E++
Sbjct: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
Query: 281 EAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFR 340
E R ++K++ +A +C+ + + + ++ +A+ RL+ TW K+ + K L
Sbjct: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
Query: 341 KFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLV-DGLVNIEKLHS 399
K + L K+ RE + PP +P++ + L DL F+ EG+ DGLVN K+
Sbjct: 377 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 436
Query: 400 VAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
++ +R IR+++ ++ +A T+ + Q V+D ++ L+E S ++E
Sbjct: 437 ISHIIREIRQFQQTAYKIEHQAK----VTQYLLDQSFVMDEES-LYESSLRIE 484
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 84.0 bits (206), Expect = 3e-16
Identities = 64/246 (26%), Positives = 114/246 (46%), Gaps = 10/246 (4%)
Query: 213 EIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHW 272
++ +V PE+ A +T +F+ + E ++ + N +R + V+ W
Sbjct: 44 DVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFW 103
Query: 273 VATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLP 332
V E+L + RA++L +IK A + +L + AVV GL +A + RL TW L
Sbjct: 104 VVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLS 163
Query: 333 GKFKNLFRKFENLTDPCRNHKSYREVISKMK-PPVIPFVPLILKDLTFLHEGSKTLVDGL 391
K K F K E + N+K R+ IS +K P IP++ + L DLT++ + L
Sbjct: 164 RKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSIL 223
Query: 392 VNIEKLHSVAEKVRTIRKYRSR-----PLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFE 446
N ++ + + +R I + P+ ++ N +Q +++F DN ++
Sbjct: 224 ENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDN----YK 279
Query: 447 LSYKLE 452
LS K+E
Sbjct: 280 LSLKIE 285
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 83.6 bits (205), Expect = 3e-16
Identities = 59/248 (23%), Positives = 119/248 (47%), Gaps = 7/248 (2%)
Query: 213 EIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHW 272
++ +V PE+ A+ +T +F+ + E + + N+ +R ++V+ W
Sbjct: 45 DVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFW 104
Query: 273 VATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLP 332
V E+L + RA++L F+KIA + +L S +VV L +A + RL TW L
Sbjct: 105 VVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLN 164
Query: 333 GKFKNLFRKFENLTDPCRNHKSYREVISKMK-PPVIPFVPLILKDLTFL---HEGSKTLV 388
K K F K + L N+K RE I +K P IP++ + L DL ++ + S +++
Sbjct: 165 RKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIM 224
Query: 389 DGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQ-VIDNQNLLFEL 447
+ +++++ + ++ S + +L++ Y+ + Q +++ N ++L
Sbjct: 225 ENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKL 282
Query: 448 SYKLEANS 455
S ++E S
Sbjct: 283 SLRIEPGS 290
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 80.5 bits (197), Expect = 3e-15
Identities = 50/209 (23%), Positives = 104/209 (49%), Gaps = 6/209 (2%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+ P ++A LT +L+R V E V V+ E + NL +++ + +T W
Sbjct: 779 LHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKC 838
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
++ E +R ++ + I+I + ++ + VV ++++ V RL T+E++P + K
Sbjct: 839 IVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQK 898
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLV----DGLV 392
+ + L++ ++K Y + + PP +PF + L ++ EG+ ++ L+
Sbjct: 899 KILEEAHELSED--HYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELI 956
Query: 393 NIEKLHSVAEKVRTIRKYRSRPLCLDMEA 421
N K VAE I++Y+++P CL +E+
Sbjct: 957 NFSKRRKVAEITGEIQQYQNQPYCLRVES 985
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 80.1 bits (196), Expect = 4e-15
Identities = 62/209 (29%), Positives = 102/209 (48%), Gaps = 26/209 (12%)
Query: 218 EPEDVANHLTAFHWELFRCVHELEFVDYVFHGE---------RGRRETANLELLLQRCSE 268
+P +A LT E + EFV + R++T NLE ++ +
Sbjct: 205 DPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNR 264
Query: 269 VTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTW 328
+++ VATE+ + RA++++ FI +A C + S A++ G++ + VSRL+ TW
Sbjct: 265 LSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTW 324
Query: 329 EKL-PGKFKNLFRKFENLTDPCRNHKSYREVI-----------SKMKPPVIPFVPLILKD 376
K+ KF L E+ DP N +YR + S + VIPF L++KD
Sbjct: 325 AKVKTAKFDIL----EHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKD 380
Query: 377 LTFLHEG-SKTLVDGLVNIEKLHSVAEKV 404
+ FL+EG + L +G VN EK +A++V
Sbjct: 381 IYFLNEGCANRLPNGHVNFEKFWELAKQV 409
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 79.7 bits (195), Expect = 5e-15
Identities = 66/228 (28%), Positives = 110/228 (48%), Gaps = 24/228 (10%)
Query: 218 EPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRR-------ETANLELLLQRCSEVT 270
+P +A LT E R + EFV + + +T+NLE ++ + +
Sbjct: 200 DPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLC 259
Query: 271 HWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEK 330
+ VATE+ + +RAQ+++ FI +A C + S A++ G++ + VSRL+ TW K
Sbjct: 260 YLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAK 319
Query: 331 L-PGKFKNLFRKFENLTDPCRNHKSYREVI-----------SKMKPPVIPFVPLILKDLT 378
+ KF L E+ DP N +YR + S + VIPF L++KD+
Sbjct: 320 VRTAKFFIL----EHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIY 375
Query: 379 FLHEG-SKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNH 425
FL+EG + L +G VN EK +A++V ++ + +AS H
Sbjct: 376 FLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITH 423
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 75.1 bits (183), Expect = 1e-13
Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 3/186 (1%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+EP ++A HLT + FR + ++ YV HG T LE + + ++ WV
Sbjct: 151 LEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPT--LERSIALFNGISKWVQLM 208
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
VL P +RA+++ KFI +A Q ++ + AVV GL ++++SRL+ T L +
Sbjct: 209 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 268
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHE-GSKTLVDGLVNIE 395
+ + L N+ +YR+ + IP + + LKDL +H + VNI
Sbjct: 269 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 328
Query: 396 KLHSVA 401
K+H ++
Sbjct: 329 KMHQLS 334
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 75.1 bits (183), Expect = 1e-13
Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 3/186 (1%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+EP ++A HLT + FR + ++ YV HG T LE + + ++ WV
Sbjct: 151 LEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPT--LERSIALFNGISKWVQLM 208
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
VL P +RA+++ KFI +A Q ++ + AVV GL ++++SRL+ T L +
Sbjct: 209 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 268
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHE-GSKTLVDGLVNIE 395
+ + L N+ +YR+ + IP + + LKDL +H + VNI
Sbjct: 269 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 328
Query: 396 KLHSVA 401
K+H ++
Sbjct: 329 KMHQLS 334
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 75.1 bits (183), Expect = 1e-13
Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 3/186 (1%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+EP ++A HLT + FR + ++ YV HG T LE + + ++ WV
Sbjct: 151 LEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPT--LERSIALFNGISKWVQLM 208
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
VL P +RA+++ KFI +A Q ++ + AVV GL ++++SRL+ T L +
Sbjct: 209 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 268
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHE-GSKTLVDGLVNIE 395
+ + L N+ +YR+ + IP + + LKDL +H + VNI
Sbjct: 269 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 328
Query: 396 KLHSVA 401
K+H ++
Sbjct: 329 KMHQLS 334
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 73.2 bits (178), Expect = 5e-13
Identities = 56/229 (24%), Positives = 106/229 (46%), Gaps = 10/229 (4%)
Query: 200 PLPEEIQVS-PGDTE---IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE 255
P P E +S PG E + + P ++A LT +L+R V E V V+ E
Sbjct: 756 PPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEIN 815
Query: 256 TANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMG 315
+ NL +++ + +T W ++ E +R +L + I+I + + + +V
Sbjct: 816 SPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSA 875
Query: 316 LDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILK 375
+++ +V RL T+E L + + + + L+ + K Y + + PP +PF + L
Sbjct: 876 VNSVSVYRLDHTFEALQERKRKILDEAVELSQD--HFKKYLVKLKSINPPCVPFFGIYLT 933
Query: 376 DLTFLHEGSKTLV----DGLVNIEKLHSVAEKVRTIRKYRSRPLCLDME 420
++ EG+ + L+N K VAE I++Y+++P CL +E
Sbjct: 934 NILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIE 982
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/238 (26%), Positives = 106/238 (44%), Gaps = 9/238 (3%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+E ++A HLT + F+ + + YV G R LE + + V+ WV
Sbjct: 200 LETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV--RGCPALEGSVGLSNSVSRWVQVM 257
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
VL P +RAQ+L KFI +A Q Q+ + AV GL ++A+SRL+ + L
Sbjct: 258 VLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 317
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGS-KTLVDGLVNIE 395
+ L N+ YR + +P + + LKDL LHE L DG +++
Sbjct: 318 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
Query: 396 KLHSVAEKVRTIRKYRSR-PLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
KL+++ +++ + + + P C S N + ++ ++ELSY E
Sbjct: 378 KLNNLYLRLQELVALQGQHPPC-----SANEDLLHLLTLSLDLFYTEDEIYELSYARE 430
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 69.7 bits (169), Expect = 5e-12
Identities = 63/238 (26%), Positives = 106/238 (44%), Gaps = 9/238 (3%)
Query: 217 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATE 276
+E ++A HLT + F+ + + YV G R LE + + V+ WV
Sbjct: 186 LETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSV--RGCPALEGSVGLSNSVSRWVQVM 243
Query: 277 VLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFK 336
VL P +RAQ+L KFI +A Q Q+ + AV GL ++A+SRL+ + L
Sbjct: 244 VLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 303
Query: 337 NLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGS-KTLVDGLVNIE 395
+ L N+ YR + +P + + LKDL LHE L DG +++
Sbjct: 304 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 363
Query: 396 KLHSVAEKVRTIRKYRSR-PLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
KL+++ +++ + + + P C S N + ++ ++ELSY E
Sbjct: 364 KLNNLYLRLQELVALQGQHPPC-----SANEDLLHLLTLSLDLFYTEDEIYELSYARE 416
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 68.2 bits (165), Expect = 2e-11
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 38/289 (13%)
Query: 193 DSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERG 252
DS EA EE + P ++ ++VA LT ELF V E + V+ +R
Sbjct: 224 DSSEACAE--EEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVW-SQRD 280
Query: 253 RRETAN----LELLLQRCSEVTHWVATEVLLCEAPG----KRAQLLKKFIKIAALCKQNQ 304
R A + + + + VT V VL APG +RAQ L+K+I+IA C++ +
Sbjct: 281 RPGAAGASPTVRATVAQFNTVTGCVLGSVL--GAPGLAAPQRAQRLEKWIRIAQRCRELR 338
Query: 305 DLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVI----- 359
+ S A++ L + + RL+ +W + + + FRK + NH S RE++
Sbjct: 339 NFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEA 398
Query: 360 ---------------SKMKPPVIPFVPLILKDLTFLHEGSKTLVDG-LVNIEKLHSVAEK 403
SK P +P++ L DL L +++G L+N EK E
Sbjct: 399 TEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEI 458
Query: 404 VRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
+ I++ + R C SP+ A Q Q+ + Q+ + LS +E
Sbjct: 459 LARIQQLQRR--CQSYTLSPHPPILAALHAQNQLTEEQS--YRLSRVIE 503
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 68.2 bits (165), Expect = 2e-11
Identities = 77/289 (26%), Positives = 126/289 (43%), Gaps = 38/289 (13%)
Query: 193 DSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERG 252
DS EA EE + P ++ ++VA LT ELF V E + V+ +R
Sbjct: 224 DSSEACAE--EEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVW-SQRD 280
Query: 253 RRETAN----LELLLQRCSEVTHWVATEVLLCEAPG----KRAQLLKKFIKIAALCKQNQ 304
R A + + + + VT V VL APG +RAQ L+K+I+IA C++ +
Sbjct: 281 RPGAAGASPTVRATVAQFNTVTGCVLGSVL--GAPGLAAPQRAQRLEKWIRIAQRCRELR 338
Query: 305 DLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVI----- 359
+ S A++ L + + RL+ +W + + + FRK + NH S RE++
Sbjct: 339 NFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEA 398
Query: 360 ---------------SKMKPPVIPFVPLILKDLTFLHEGSKTLVDG-LVNIEKLHSVAEK 403
SK P +P++ L DL L +++G L+N EK E
Sbjct: 399 TEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEI 458
Query: 404 VRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
+ I++ + R C SP+ A Q Q+ + Q+ + LS +E
Sbjct: 459 LARIQQLQRR--CQSYTLSPHPPILAALHAQNQLTEEQS--YRLSRVIE 503
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,633,757
Number of Sequences: 37866
Number of extensions: 774732
Number of successful extensions: 2063
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1957
Number of HSP's gapped (non-prelim): 62
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.