Search of human proteins with 140161500

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
         (1134 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|140161500 ankyrin repeat and sterile alpha motif domain conta...  2274   0.0  
gi|50511945 cajalin 2 isoform a [Homo sapiens]                        569   e-162
gi|50511947 cajalin 2 isoform b [Homo sapiens]                        503   e-142
gi|10047134 cajalin 2 isoform c [Homo sapiens]                        463   e-130
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]      208   3e-53
gi|18079216 CASK interacting protein 1 [Homo sapiens]                 189   1e-47
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]      166   9e-41
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        137   6e-32
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    127   8e-29
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       126   1e-28
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        126   1e-28
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        126   1e-28
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        126   1e-28
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        126   1e-28
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       125   2e-28
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        125   2e-28
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        125   2e-28
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   117   5e-26
gi|110431370 espin [Homo sapiens]                                     117   6e-26
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]          114   5e-25
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]        114   5e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   112   2e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   112   2e-24
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   112   2e-24
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   112   2e-24
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   112   2e-24
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    112   2e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          111   3e-24
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   110   8e-24
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   109   1e-23

>gi|140161500 ankyrin repeat and sterile alpha motif domain containing
            1 [Homo sapiens]
          Length = 1134

 Score = 2274 bits (5892), Expect = 0.0
 Identities = 1134/1134 (100%), Positives = 1134/1134 (100%)

Query: 1    MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
            MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP
Sbjct: 1    MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60

Query: 61   LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
            LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA
Sbjct: 61   LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120

Query: 121  AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
            AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN
Sbjct: 121  AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180

Query: 181  KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240
            KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD
Sbjct: 181  KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240

Query: 241  SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA 300
            SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA
Sbjct: 241  SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA 300

Query: 301  LIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGP 360
            LIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGP
Sbjct: 301  LIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGP 360

Query: 361  YEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGVRPRERPPPPAKPPPDEEEE 420
            YEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGVRPRERPPPPAKPPPDEEEE
Sbjct: 361  YEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGVRPRERPPPPAKPPPDEEEE 420

Query: 421  DHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYELLLTAETKKVVLVDGKTKDHRRSS 480
            DHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYELLLTAETKKVVLVDGKTKDHRRSS
Sbjct: 421  DHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYELLLTAETKKVVLVDGKTKDHRRSS 480

Query: 481  SSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLCTAGQSHPDGSPQQGACHKA 540
            SSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLCTAGQSHPDGSPQQGACHKA
Sbjct: 481  SSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLCTAGQSHPDGSPQQGACHKA 540

Query: 541  SMQLEETGVHAPGASQPSALDQSKRVGYLTGLPTTNSRSHPETLTHTASPHPGGAEEGDR 600
            SMQLEETGVHAPGASQPSALDQSKRVGYLTGLPTTNSRSHPETLTHTASPHPGGAEEGDR
Sbjct: 541  SMQLEETGVHAPGASQPSALDQSKRVGYLTGLPTTNSRSHPETLTHTASPHPGGAEEGDR 600

Query: 601  SGARSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEK 660
            SGARSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEK
Sbjct: 601  SGARSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEK 660

Query: 661  SPSFASEWDEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLN 720
            SPSFASEWDEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLN
Sbjct: 661  SPSFASEWDEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLN 720

Query: 721  GFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLD 780
            GFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLD
Sbjct: 721  GFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLD 780

Query: 781  SLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQK 840
            SLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQK
Sbjct: 781  SLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQK 840

Query: 841  PPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRRRHDSLHDPAAPSRAERF 900
            PPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRRRHDSLHDPAAPSRAERF
Sbjct: 841  PPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRRRHDSLHDPAAPSRAERF 900

Query: 901  RIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTES 960
            RIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTES
Sbjct: 901  RIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTES 960

Query: 961  TQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLC 1020
            TQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLC
Sbjct: 961  TQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLC 1020

Query: 1021 TFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAE 1080
            TFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAE
Sbjct: 1021 TFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAE 1080

Query: 1081 MIETKSSKPVPKPRVGVRKSALEPPDMDQDAQSHASVSWVVDPKPDSKRSLSTN 1134
            MIETKSSKPVPKPRVGVRKSALEPPDMDQDAQSHASVSWVVDPKPDSKRSLSTN
Sbjct: 1081 MIETKSSKPVPKPRVGVRKSALEPPDMDQDAQSHASVSWVVDPKPDSKRSLSTN 1134


>gi|50511945 cajalin 2 isoform a [Homo sapiens]
          Length = 1248

 Score =  569 bits (1466), Expect = e-162
 Identities = 329/668 (49%), Positives = 430/668 (64%), Gaps = 43/668 (6%)

Query: 463  TKKVVLVDGKTKDHRRSSSSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLL-- 520
            T  V   + K +    +     QD  +      P QF+GLLHGSSP CE  ++PF L   
Sbjct: 569  TSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGK 628

Query: 521  ---CTAGQSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRVGYLTGLPTTNS 577
               C  GQ        + +   + +  +++ +     S+P       +V   T     ++
Sbjct: 629  REQCEKGQD-------EVSLANSPLPFKQSPIE--NNSEPLVKKIKPKVVSRTIFHKKSN 679

Query: 578  RSHPETLTHTASPHPGGAEEGDR-----SGARSRAPPTSK----PKA--ELKLSRSLSKS 626
            +    T+  T S    G+  GD+      G   RA    +    PKA  ++ LS+S+SKS
Sbjct: 680  QLENHTIVGTRSTR-SGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKS 738

Query: 627  DSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGIDFSQ 686
            DSDL+     E  +  + SES +     K   E++PSF SEW+EI+KIMSSI  GI+   
Sbjct: 739  DSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGIN--N 796

Query: 687  ERQKISGLRTLE----QSVGEWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIG 742
            E ++++G  T      Q+VG+WLESIGL QYE+ L+ NGFD+V F+GSNVME+QDL +IG
Sbjct: 797  ELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIG 856

Query: 743  ISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTV 802
            I +  HR+++LQA + LPK++ +G+DG  P SV  WLDS+ L DY  +FL +GY+S+D +
Sbjct: 857  ILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLL 916

Query: 803  KNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLR---CQDLLSQTSSP 859
            K +WE+EL+NVLK+ L+GHRKRI+ASL DR +++PPQKPPR   LR         Q S  
Sbjct: 917  KKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPS 976

Query: 860  LSQNDSCTGRSADL--LLPPGDTGRRRHDSLHDPAAPSRAERFRIQE-EHREAKLTLRPP 916
            LSQ+   TG S D+  ++  GD  RRR+++  D    S+ ER   Q  +  E  +TLRPP
Sbjct: 977  LSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPP 1036

Query: 917  SLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMR----KST 972
            + A    PVQ WQH PEKLIF+SC Y+A YLGSMLIK+LRGTESTQDACAKMR    KST
Sbjct: 1037 NEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST 1096

Query: 973  EHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTS 1032
            E MKK+PTIILS++YKGVKFIDA+NKN+IAEHEIRNISCAAQDPEDL TFAYITKDL+++
Sbjct: 1097 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 1156

Query: 1033 HHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAEMIETKSSKPVPK 1092
            HHYCHVF+  DVNL YEIILTLGQAFEVAYQLALQA+K     ++  E  E K SKP+PK
Sbjct: 1157 HHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKG-GHSSTLPESFENKPSKPIPK 1215

Query: 1093 PRVGVRKS 1100
            PRV +RKS
Sbjct: 1216 PRVSIRKS 1223



 Score =  444 bits (1141), Expect = e-124
 Identities = 233/382 (60%), Positives = 293/382 (76%), Gaps = 26/382 (6%)

Query: 1   MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
           MGK+QELLEAARTG++  VEKLLSG++                GG  GGG G L     P
Sbjct: 1   MGKDQELLEAARTGNVALVEKLLSGRK----------------GGILGGGSGPL-----P 39

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
           LS+LLS+WRGPNVNC DS+GYT LHHAALNGHKD+V  LL+ +A TNVAD+KG +P+HLA
Sbjct: 40  LSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLA 99

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           AWKGD +IV++LIH GPSH+RVNEQNN+NETALHCAAQYGH+EVV VLLEELTDPT+RN+
Sbjct: 100 AWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNS 159

Query: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240
           K ETPLDLAALYGRL VVKM+++AHPNL+SCNT+KHTPLHLAARNGHKAVVQVLL+AGMD
Sbjct: 160 KLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMD 219

Query: 241 SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA 300
            + QTE GSALHEAALFGK DVV++LL  G D NIKD+ G T LD ++E PSQKS QIA 
Sbjct: 220 VSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIAT 279

Query: 301 LIEDHMTG-KRST---KEVDKTPPPQPPLISSMDSISQKSQGD-VEKAVTELIIDFDANA 355
           L+++++ G  RST   + V +    +  + S ++S SQK++ + V   +++L+ +     
Sbjct: 280 LLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQ 339

Query: 356 EEEGPYEALYNAISCHSLDSMA 377
           E++  +E L + IS H LD+++
Sbjct: 340 EKDYSFEDLCHTISDHYLDNLS 361


>gi|50511947 cajalin 2 isoform b [Homo sapiens]
          Length = 510

 Score =  503 bits (1294), Expect = e-142
 Identities = 264/477 (55%), Positives = 337/477 (70%), Gaps = 38/477 (7%)

Query: 691  ISGLRTLEQSVGEWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRR 750
            ++G R   Q+VG+WLESIGL QYE+ L+ NGFD+V F+GSNVME+QDL +IGI +  HR+
Sbjct: 31   LTGPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQ 90

Query: 751  KLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELEL 810
            ++LQA + LPK++ +G+DG  P SV  WLDS+ L DY  +FL +GY+S+D +K +WE+EL
Sbjct: 91   RILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVEL 150

Query: 811  VNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLR---CQDLLSQTSSPLSQNDSCT 867
            +NVLK+ L+GHRKRI+ASL DR +++PPQKPPR   LR         Q S  LSQ+   T
Sbjct: 151  INVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTT 210

Query: 868  GRSADL--LLPPGDTGRRRHDSLHDPAAPSRAERFRIQE--------------------- 904
            G S D+  ++  GD  RRR+++  D    S+ ER   Q                      
Sbjct: 211  GGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQSSVCEIWTNQNAGFPFSAIHQV 270

Query: 905  ----EHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTES 960
                +  E  +TLRPP+ A    PVQ WQH PEKLIF+SC Y+A YLGSMLIK+LRGTES
Sbjct: 271  HNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTES 330

Query: 961  TQDACAKMR----KSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDP 1016
            TQDACAKMR    KSTE MKK+PTIILS++YKGVKFIDA+NKN+IAEHEIRNISCAAQDP
Sbjct: 331  TQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDP 390

Query: 1017 EDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGA 1076
            EDL TFAYITKDL+++HHYCHVF+  DVNL YEIILTLGQAFEVAYQLALQA+K     +
Sbjct: 391  EDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKG-GHSS 449

Query: 1077 SAAEMIETKSSKPVPKPRVGVRKSALEPPDMDQDAQSHASVSWVVDPKPDSKRSLST 1133
            +  E  E K SKP+PKPRV +RKS    P    + ++ A++ W+V+P  ++KR ++T
Sbjct: 450  TLPESFENKPSKPIPKPRVSIRKSVQIDP---SEQKTLANLPWIVEPGQEAKRGINT 503


>gi|10047134 cajalin 2 isoform c [Homo sapiens]
          Length = 414

 Score =  463 bits (1191), Expect = e-130
 Identities = 240/414 (57%), Positives = 293/414 (70%), Gaps = 59/414 (14%)

Query: 691  ISGLRTLEQSVGEWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRR 750
            ++G R   Q+VG+WLESIGL QYE+ L+ NGFD+V F+GSNVME+QDL +IGI +  HR+
Sbjct: 31   LTGPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQ 90

Query: 751  KLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELEL 810
            ++LQA + LPK++ +G+DG  P SV  WLDS+ L DY  +FL +GY+S+D +K +WE+EL
Sbjct: 91   RILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVEL 150

Query: 811  VNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLLSQTSSPLSQNDSCTGRS 870
            +NVLK+ L+GHRKRI+ASL DR +++PPQKPPR   LR                      
Sbjct: 151  INVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLR---------------------- 188

Query: 871  ADLLLPPGDTGRRRHDSLHDPAAPSRAERFRIQEEHREAKLTLRPPSLAAPYAPVQSWQH 930
                   GD G                          E  +TLRPP+ A    PVQ WQH
Sbjct: 189  ------TGDWG--------------------------EPSITLRPPNEATASTPVQYWQH 216

Query: 931  QPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMR----KSTEHMKKIPTIILSIT 986
             PEKLIF+SC Y+A YLGSMLIK+LRGTESTQDACAKMR    KSTE MKK+PTIILS++
Sbjct: 217  HPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVS 276

Query: 987  YKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNL 1046
            YKGVKFIDA+NKN+IAEHEIRNISCAAQDPEDL TFAYITKDL+++HHYCHVF+  DVNL
Sbjct: 277  YKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNL 336

Query: 1047 TYEIILTLGQAFEVAYQLALQAQKSRATGASAAEMIETKSSKPVPKPRVGVRKS 1100
             YEIILTLGQAFEVAYQLALQA+K     ++  E  E K SKP+PKPRV +RKS
Sbjct: 337  AYEIILTLGQAFEVAYQLALQARKG-GHSSTLPESFENKPSKPIPKPRVSIRKS 389


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score =  208 bits (529), Expect = 3e-53
 Identities = 121/313 (38%), Positives = 182/313 (58%), Gaps = 43/313 (13%)

Query: 1   MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
           MG+EQ+L+ A + G +  V+KL++  + +                               
Sbjct: 1   MGREQDLILAVKNGDVTGVQKLVAKVKATK------------------------------ 30

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
            + LL   +  NVN  D+ G++ LHHAAL G  +++ +LL   A  ++ DS G  PLH A
Sbjct: 31  -TKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYA 89

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           AW+G  + VRLL+    +   VN  + D +  LH AAQYGH EV ++LL+  ++P + N 
Sbjct: 90  AWQGRLEPVRLLLR---ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNK 146

Query: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLL--------SCNTKKHTPLHLAARNGHKAVVQ 232
             +TPLDLA  +GRL+V ++LLN+H  +          C+    TPLHLAA+NGH+ V++
Sbjct: 147 AKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIR 206

Query: 233 VLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVREL-P 291
            LL AG++ N QT+ G+ALHEAAL+GKT+VV++LL  G DVNI++ +  TALD V +   
Sbjct: 207 QLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTT 266

Query: 292 SQKSQQIAALIED 304
           SQ S++I  L+ +
Sbjct: 267 SQASREIKQLLRE 279



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 83/337 (24%), Positives = 125/337 (37%), Gaps = 45/337 (13%)

Query: 515 DPFQLLCTAG------QSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRVGY 568
           DP  L   AG      + HPDG   +G  H++    +  G   PG  +      SKRVG 
Sbjct: 297 DPTALNVRAGDVITVLEQHPDGR-WKGHIHESQRGTDRIGYFPPGIVEVV----SKRVGI 351

Query: 569 ---------------LTGLPTTNSRSHPETLTHTASPHPGGAEE---GDRSGARSRAPPT 610
                           +  P   +   P  LT++  P  G + +   GDR+   S     
Sbjct: 352 PAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVG 411

Query: 611 SKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDE 670
           S   A    S   +      L     +        + L             PS A     
Sbjct: 412 SIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLH--------PPSLADNLSH 463

Query: 671 IEKIMSSIGEGIDFSQERQKISGLRTLE-QSVGEWLESIGLQQYESKLLLNGFDDVHFLG 729
                   GE I F+Q+ +    L   + Q++  WL    L+ Y +  L  G+D      
Sbjct: 464 RPLANCRSGEQI-FTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTI-- 520

Query: 730 SNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVH 789
            + M  +DL  IG++ P HR+K+      L   + L      P  +  WL +LGL  Y  
Sbjct: 521 -SRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWL--PSYIPTDLLEWLCALGLPQYHK 577

Query: 790 SFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRII 826
             +SSGY S+  V +L   EL  +  V  LGH+K+++
Sbjct: 578 QLVSSGYDSMGLVADLTWEELQEI-GVNKLGHQKKLM 613



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 19/61 (31%), Positives = 38/61 (62%), Gaps = 2/61 (3%)

Query: 703 EWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKV 762
           EWL ++GL QY  +L+ +G+D +  +     EE  L++IG++   H++KL+   + L ++
Sbjct: 565 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 622

Query: 763 K 763
           +
Sbjct: 623 R 623



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 2/63 (3%)

Query: 768 DGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIA 827
           +G    ++ +WL    L+ Y   FL +GY  + T+  +   +L   + V   GHRK+I +
Sbjct: 487 EGKDAQAIHNWLSEFQLEGYTAHFLQAGY-DVPTISRMTPEDL-TAIGVTKPGHRKKIAS 544

Query: 828 SLA 830
            +A
Sbjct: 545 EIA 547


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score =  189 bits (480), Expect = 1e-47
 Identities = 113/313 (36%), Positives = 183/313 (58%), Gaps = 43/313 (13%)

Query: 1   MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
           MGKEQEL++A +   +   ++LL   R                                 
Sbjct: 1   MGKEQELVQAVKAEDVGTAQRLLQRPRPGK------------------------------ 30

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
            + LL   +  NVN  D  G++ LHHAALNG+ +++ +LL   A  ++ D+KG  PLH A
Sbjct: 31  -AKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYA 89

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           AW+G  + ++L++  G   + VN  +++    LH AAQ+GH +V ++LL+  ++P M +N
Sbjct: 90  AWQGRKEPMKLVLKAG---SAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDN 146

Query: 181 KFETPLDLAALYGRLEVVKMLLNAH--PNLL------SCNTKKHTPLHLAARNGHKAVVQ 232
             +TPLDLA  +GR+ VV++LL+++    LL      + +    +PLHLAA+NGH  +++
Sbjct: 147 SGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIR 206

Query: 233 VLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVREL-P 291
           +LL AG+D N QT+ G+ALHEAAL GKT+VV++LL +G + ++++ +  TALD V +   
Sbjct: 207 LLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTT 266

Query: 292 SQKSQQIAALIED 304
           SQ S++I  L+ +
Sbjct: 267 SQASREIKQLLRE 279



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 137/645 (21%), Positives = 232/645 (35%), Gaps = 132/645 (20%)

Query: 219 LHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGTDVNIKD 277
           LH AA NG+  ++ +LL+A    + +   G   LH AA  G+ + ++++L AG+ VNI  
Sbjct: 53  LHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPS 112

Query: 278 NHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQ 337
           + G   L    +        ++ ++  H +         KTP                  
Sbjct: 113 DEGHIPLHLAAQ---HGHYDVSEMLLQHQSNPCMVDNSGKTP------------------ 151

Query: 338 GDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVK 397
                      +D        G  + L ++  C +L     G ++D + T+    AA   
Sbjct: 152 -----------LDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAA--- 197

Query: 398 PAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYEL 457
                                +  HID     L A   ++ + +  G+A        +E 
Sbjct: 198 ---------------------KNGHIDIIRLLLQAGIDINRQTK-SGTAL-------HEA 228

Query: 458 LLTAETKKV-VLVDGKTKDHRRSSSSRSQDSAEGQ--DGQVPEQFSGLLHGSSPVCEV-- 512
            L  +T+ V +L+D     H R++ S++      Q    Q   +   LL  +S   +V  
Sbjct: 229 ALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRA 288

Query: 513 ------GQDPFQLLCTAG------QSHPDGSPQQGACHKASMQLEETGVHAPGASQPSAL 560
                   D   L   AG      + HPDG   +G  H      +  G       +    
Sbjct: 289 TKDYCNNYDLTSLNVKAGDIITVLEQHPDGR-WKGCIHDNRTGNDRVGYFPSSLGEAIVK 347

Query: 561 DQSKRVGYLTGLPTTNSRSHP----ETLTHTASPHPGGAEEGDRSG----------ARSR 606
               R G    LP  +S S P    E +     P  GG   G  SG          A   
Sbjct: 348 RAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHA 407

Query: 607 APPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFAS 666
                K  A +   +S+S+S        P E +   +RS+       G+   E+ P    
Sbjct: 408 GSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQP-PVAHAGQVYGEQPP---- 462

Query: 667 EWDEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLNGFDDVH 726
                 K +    EG                 ++V +WL +  LQ Y    +  G+D   
Sbjct: 463 ------KKLEPASEGKS--------------SEAVSQWLTAFQLQLYAPNFISAGYD--- 499

Query: 727 FLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQD 786
               + M  +DL  IG++ P HR+K+      L     L    + P ++  WL  +GL  
Sbjct: 500 LPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWL--PEHKPANLAVWLSMIGLAQ 557

Query: 787 YVHSFLSSGYSSIDTVKNL-WE-LELVNVLKVQLLGHRKRIIASL 829
           Y    + +GY +ID + ++ WE L+ + + K   LGH+K+++ ++
Sbjct: 558 YYKVLVDNGYENIDFITDITWEDLQEIGITK---LGHQKKLMLAV 599



 Score = 38.5 bits (88), Expect = 0.037
 Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 4/84 (4%)

Query: 760 PKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLL 819
           PK      +G S  +V  WL +  LQ Y  +F+S+GY  + T+  +   +L   + V   
Sbjct: 462 PKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGY-DLPTISRMTPEDL-TAIGVTKP 519

Query: 820 GHRKRIIASLADRPYEE--PPQKP 841
           GHRK+I A ++     +  P  KP
Sbjct: 520 GHRKKIAAEISGLSIPDWLPEHKP 543


>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score =  166 bits (421), Expect = 9e-41
 Identities = 91/198 (45%), Positives = 131/198 (66%), Gaps = 12/198 (6%)

Query: 116 PLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDP 175
           PLH AAW+G  + VRLL+    +   VN  + D +  LH AAQYGH EV ++LL+  ++P
Sbjct: 3   PLHYAAWQGRLEPVRLLLRASAA---VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 59

Query: 176 TMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLL--------SCNTKKHTPLHLAARNGH 227
            + N   +TPLDLA  +GRL+V ++LLN+H  +          C+    TPLHLAA+NGH
Sbjct: 60  CLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGH 119

Query: 228 KAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTV 287
           + V++ LL AG++ N QT+ G+ALHEAAL+GKT+VV++LL  G DVNI++ +  TALD V
Sbjct: 120 REVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179

Query: 288 REL-PSQKSQQIAALIED 304
            +   SQ S++I  L+ +
Sbjct: 180 NQFTTSQASREIKQLLRE 197



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 83/337 (24%), Positives = 125/337 (37%), Gaps = 45/337 (13%)

Query: 515 DPFQLLCTAG------QSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRVGY 568
           DP  L   AG      + HPDG   +G  H++    +  G   PG  +      SKRVG 
Sbjct: 215 DPTALNVRAGDVITVLEQHPDGR-WKGHIHESQRGTDRIGYFPPGIVEVV----SKRVGI 269

Query: 569 ---------------LTGLPTTNSRSHPETLTHTASPHPGGAEE---GDRSGARSRAPPT 610
                           +  P   +   P  LT++  P  G + +   GDR+   S     
Sbjct: 270 PAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVG 329

Query: 611 SKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDE 670
           S   A    S   +      L     +        + L             PS A     
Sbjct: 330 SIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLH--------PPSLADNLSH 381

Query: 671 IEKIMSSIGEGIDFSQERQKISGLRTLE-QSVGEWLESIGLQQYESKLLLNGFDDVHFLG 729
                   GE I F+Q+ +    L   + Q++  WL    L+ Y +  L  G+D      
Sbjct: 382 RPLANCRSGEQI-FTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTI-- 438

Query: 730 SNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVH 789
            + M  +DL  IG++ P HR+K+      L   + L      P  +  WL +LGL  Y  
Sbjct: 439 -SRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWL--PSYIPTDLLEWLCALGLPQYHK 495

Query: 790 SFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRII 826
             +SSGY S+  V +L   EL  +  V  LGH+K+++
Sbjct: 496 QLVSSGYDSMGLVADLTWEELQEI-GVNKLGHQKKLM 531



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 19/61 (31%), Positives = 38/61 (62%), Gaps = 2/61 (3%)

Query: 703 EWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKV 762
           EWL ++GL QY  +L+ +G+D +  +     EE  L++IG++   H++KL+   + L ++
Sbjct: 483 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 540

Query: 763 K 763
           +
Sbjct: 541 R 541



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 2/63 (3%)

Query: 768 DGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIA 827
           +G    ++ +WL    L+ Y   FL +GY  + T+  +   +L   + V   GHRK+I +
Sbjct: 405 EGKDAQAIHNWLSEFQLEGYTAHFLQAGY-DVPTISRMTPEDL-TAIGVTKPGHRKKIAS 462

Query: 828 SLA 830
            +A
Sbjct: 463 EIA 465


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  137 bits (345), Expect = 6e-32
 Identities = 106/345 (30%), Positives = 166/345 (48%), Gaps = 26/345 (7%)

Query: 64  LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
           LL     PN   ++  G+TPLH A       V+E+LL++ A        G  P+H+AA+ 
Sbjct: 386 LLDKKANPNAKALN--GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443

Query: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFE 183
           G   IV  L+H G S    N  N   ETALH AA+ G  EVV+ L+++      +    +
Sbjct: 444 GHVNIVSQLMHHGASP---NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500

Query: 184 TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
           TPL ++A  G+ ++V+ LL    +  +  T  +TPLHL+AR GH+ V   LLD G   + 
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALI 302
            T+ G + LH AA +GK +V  +LL      +     GLT L       +QK   +A L+
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQK---VALLL 617

Query: 303 EDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGPYE 362
            D      +  +   TP         +   ++K+Q D+  A T L    DANA       
Sbjct: 618 LDQGASPHAAAKNGYTP---------LHIAAKKNQMDI--ATTLLEYGADANAVTRQGIA 666

Query: 363 ALYNAISCHSLD--SMASGRSSDQDSTNKEAEAAGVKPAGVRPRE 405
           +++ A     +D  S+  GR+++ + +NK    +G+ P  +  +E
Sbjct: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNK----SGLTPLHLAAQE 707



 Score =  114 bits (284), Expect = 7e-25
 Identities = 83/256 (32%), Positives = 122/256 (47%), Gaps = 13/256 (5%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  ++     G TPLH  A +GH+ VVE+LL   A        G  PLH+A        
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           V+LL+     +  V++  ND  TALH AA  GH +V KVLL++  +P  +     TPL +
Sbjct: 350 VQLLLQH---NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           A    R++V+++LL    ++ +      TP+H+AA  GH  +V  L+  G   N     G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL---------DTVRELPSQKSQQI 298
            +ALH AA  G+ +VV+ L+  G  V  K     T L         D V++L  Q +   
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526

Query: 299 AALIEDHMTGKRSTKE 314
           AA    +     S +E
Sbjct: 527 AATTSGYTPLHLSARE 542



 Score =  102 bits (253), Expect = 3e-21
 Identities = 78/246 (31%), Positives = 115/246 (46%), Gaps = 33/246 (13%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           R  NV+     G T LH A+L G  +VV+VL+ N A  N     G  PL++AA +   ++
Sbjct: 96  REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV 155

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR---------- 178
           V+ L+  G S +   E   D  T L  A Q GH +VV +LLE  T   +R          
Sbjct: 156 VKFLLDNGASQSLATE---DGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARK 212

Query: 179 ------------NNKFE-------TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPL 219
                       +N  +       TPL +AA YG + V  +LLN    +        TPL
Sbjct: 213 DDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPL 272

Query: 220 HLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
           H+A++ G+  +V++LLD G   + +T  G + LH  A  G   VV++LL     +  K  
Sbjct: 273 HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332

Query: 279 HGLTAL 284
           +GL+ L
Sbjct: 333 NGLSPL 338



 Score =  101 bits (252), Expect = 4e-21
 Identities = 84/244 (34%), Positives = 115/244 (47%), Gaps = 31/244 (12%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NVN     G+TPL+ AA   H +VV+ LL N A  ++A   G  PL +A  +G  Q+V
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189

Query: 130 RLLIHQGPS---------------HTRV------NEQNNDNE-----TALHCAAQYGHTE 163
            LL+                     T+       N+ N D E     T LH AA YG+  
Sbjct: 190 SLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249

Query: 164 VVKVLLEELT--DPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHL 221
           V  +LL      D T RN+   TPL +A+  G   +VK+LL+    + +      TPLH 
Sbjct: 250 VATLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHC 307

Query: 222 AARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHG 280
            AR+GH+ VV++LLD       +T+ G S LH A      + VQ+LL     V+   N  
Sbjct: 308 GARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY 367

Query: 281 LTAL 284
           LTAL
Sbjct: 368 LTAL 371



 Score =  100 bits (248), Expect = 1e-20
 Identities = 73/242 (30%), Positives = 109/242 (45%), Gaps = 10/242 (4%)

Query: 63  SLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAW 122
           +LL + +G + +     GYTPLH AA     D+   LL   A  N    +G   +HLAA 
Sbjct: 614 ALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 673

Query: 123 KGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
           +G   +V LL+ +   +  VN  N    T LH AAQ     V +VL+ +      +    
Sbjct: 674 EGHVDMVSLLLGR---NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730

Query: 183 ETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDS 241
            TPL +   YG +++V  LL  H   ++  TK  +TPLH AA+ GH  ++ VLL      
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAG----TDVNIKDNHGLTALDTVRELPSQKSQ 296
           N  T  G +AL  A   G   VV  L        T   + + H +   +T+ E+      
Sbjct: 790 NELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDD 849

Query: 297 QI 298
           ++
Sbjct: 850 EV 851



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 83/290 (28%), Positives = 132/290 (45%), Gaps = 28/290 (9%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH A+  GH +VV  LL+ +A  + A  KG   LH+A+  G A++V
Sbjct: 64  GVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVV 123

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           ++L+  G     VN Q+ +  T L+ AAQ  H EVVK LL+     ++      TPL +A
Sbjct: 124 KVLVTNG---ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTP-LHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
              G  +VV +LL           K   P LH+AAR        +LL    +++ +++ G
Sbjct: 181 LQQGHDQVVSLLLEN-----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSG 235

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVR--------ELPSQKSQQIA 299
            + LH AA +G  +V  +LL     V+    + +T L            +L   +  +I 
Sbjct: 236 FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID 295

Query: 300 ALIEDHMT----GKRSTKE------VDKTPPPQPPLISSMDSISQKSQGD 339
           A   D +T    G RS  E      +D+  P      + +  +   +QGD
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGD 345



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 60/198 (30%), Positives = 90/198 (45%), Gaps = 6/198 (3%)

Query: 87  AALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQN 146
           AA  GH +     ++N    N+ +  G   LHLA+ +G  ++V  L+ +      V+   
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR---EANVDAAT 104

Query: 147 NDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHP 206
               TALH A+  G  EVVKVL+    +   ++    TPL +AA    LEVVK LL+   
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164

Query: 207 NLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQIL 266
           +         TPL +A + GH  VV +LL+       +     ALH AA    T    +L
Sbjct: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRL---PALHIAARKDDTKAAALL 221

Query: 267 LAAGTDVNIKDNHGLTAL 284
           L    + +++   G T L
Sbjct: 222 LQNDNNADVESKSGFTPL 239



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 3/171 (1%)

Query: 140 TRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVK 199
           +R  ++ +D   +   AA+ GH E     ++   D  + N      L LA+  G +EVV 
Sbjct: 32  SRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVS 91

Query: 200 MLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFG 258
            LL    N+ +   K +T LH+A+  G   VV+VL+  G + N Q++ G + L+ AA   
Sbjct: 92  ELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN 151

Query: 259 KTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGK 309
             +VV+ LL  G   ++    G T L     L     Q ++ L+E+   GK
Sbjct: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVA--LQQGHDQVVSLLLENDTKGK 200


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  127 bits (318), Expect = 8e-29
 Identities = 80/224 (35%), Positives = 125/224 (55%), Gaps = 4/224 (1%)

Query: 62  SSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAA 121
           S+ L + +  +VN VD  G TP+H A  +G +++V +LLR     ++       PLH AA
Sbjct: 519 STRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578

Query: 122 WKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
           W+G   IV+LL  Q      VN Q  D  T LH AAQ GH  V ++L++  +D  + +  
Sbjct: 579 WQGHLPIVKLLAKQ--PGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLL 636

Query: 182 FETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
            +TPL +AA  G     ++LL+      +  +  +T LHLAARNGH A V++L++   D 
Sbjct: 637 AQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADV 696

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             +  +  +ALH AA  G ++VV+ L++A   +++ D  GL+AL
Sbjct: 697 LARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSAL 739



 Score =  100 bits (248), Expect = 1e-20
 Identities = 70/186 (37%), Positives = 94/186 (50%), Gaps = 4/186 (2%)

Query: 60  PLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHL 119
           P+  LL+   G +VN     G TPLH AA  GH  V  +L+   +  NV       PLH+
Sbjct: 584 PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHV 643

Query: 120 AAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRN 179
           AA  G     RLL+H+G          +D  TALH AA+ GH   VK+L+EE  D   R 
Sbjct: 644 AAETGHTSTARLLLHRGAGK---EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG 700

Query: 180 NKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGM 239
              +T L LAA +G  EVV+ L++A    L  + +  + LHLAA+  H   V+ LL  G 
Sbjct: 701 PLNQTALHLAAAHGHSEVVEELVSADVIDL-FDEQGLSALHLAAQGRHAQTVETLLRHGA 759

Query: 240 DSNYQT 245
             N Q+
Sbjct: 760 HINLQS 765



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 63/225 (28%), Positives = 105/225 (46%), Gaps = 38/225 (16%)

Query: 62  SSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAA 121
           S L+ + +  +V+    +G + LH A   G ++  + LL N+A  N+++ +G  PLH+A 
Sbjct: 420 SKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479

Query: 122 WKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
            +    +V LL+ +  S   VN ++ D  TALH AAQ G     ++LLE+          
Sbjct: 480 ERRVRGVVELLLARKIS---VNAKDEDQWTALHFAAQNGDESSTRLLLEK---------- 526

Query: 182 FETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
                                NA  N    + +  TP+H+A ++G + +V++LL  G+D 
Sbjct: 527 ---------------------NASVN--EVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563

Query: 242 NYQ-TEMGSALHEAALFGKTDVVQILL-AAGTDVNIKDNHGLTAL 284
           + Q  +    LH AA  G   +V++L    G  VN +   G T L
Sbjct: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPL 608



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 39/127 (30%), Positives = 61/127 (48%), Gaps = 4/127 (3%)

Query: 57  SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP 116
           + H  ++ L + RG     + S GYT LH AA NGH   V++L+   A            
Sbjct: 647 TGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA 706

Query: 117 LHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT 176
           LHLAA  G +++V  L+    S   ++  +    +ALH AAQ  H + V+ LL       
Sbjct: 707 LHLAAAHGHSEVVEELV----SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762

Query: 177 MRNNKFE 183
           +++ KF+
Sbjct: 763 LQSLKFQ 769



 Score = 33.9 bits (76), Expect = 0.90
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 7/99 (7%)

Query: 219 LHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGTDVNIKD 277
           LHLA   G +   + LL    + N     GS  LH A       VV++LLA    VN KD
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501

Query: 278 NHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVD 316
               TAL    +   + S ++  L+E +     S  EVD
Sbjct: 502 EDQWTALHFAAQNGDESSTRL--LLEKN----ASVNEVD 534


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  126 bits (316), Expect = 1e-28
 Identities = 76/216 (35%), Positives = 116/216 (53%), Gaps = 4/216 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G +++ V  +G TPLH A+  GH  +V+ LL+  A  NV++ K   PLH+AA  G  ++ 
Sbjct: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 486

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + L+    +  +VN +  D++T LHCAA+ GHT +VK+LLE   +P +      TPL +A
Sbjct: 487 KYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG- 248
           A  G +E V  LL    +      K  TPLH+AA+ G   V ++LL+     N   + G 
Sbjct: 544 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 603

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + LH A      D+V++LL  G   +    +G T L
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 639



 Score =  117 bits (292), Expect = 8e-26
 Identities = 71/215 (33%), Positives = 110/215 (51%), Gaps = 4/215 (1%)

Query: 71  PNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVR 130
           PN + +  TG+TPLH AA   + +V ++LL   A  N     G  PLH+A+ +G+  +VR
Sbjct: 230 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 289

Query: 131 LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAA 190
           LL+ +G    ++  +  D  T LHCAA+ GH  + ++LL+       +     +P+ +AA
Sbjct: 290 LLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 346

Query: 191 LYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-S 249
               L+ V++LL     +        TPLH+AA  GH  V +VLLD G   N +   G +
Sbjct: 347 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 406

Query: 250 ALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            LH A       V+++LL  G  ++     GLT L
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441



 Score =  115 bits (288), Expect = 2e-25
 Identities = 83/248 (33%), Positives = 118/248 (47%), Gaps = 33/248 (13%)

Query: 75  CVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIH 134
           C+   G+TPLH AA  G   V E+LL  DA  N A   G  PLH+A    +  IV+LL+ 
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623

Query: 135 QG------------PSHTRV------------------NEQNNDNETALHCAAQYGHTEV 164
           +G            P H                     N ++    T LH AAQ GH E+
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683

Query: 165 VKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAA 223
           V +LL +  +  + N    TPL L A  G + V  +L+  H  ++   T+  +TPLH+A+
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 742

Query: 224 RNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLT 282
             G+  +V+ LL    D N +T++G S LH+AA  G TD+V +LL  G   N   + G T
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 802

Query: 283 ALDTVREL 290
            L   + L
Sbjct: 803 PLAIAKRL 810



 Score =  110 bits (275), Expect = 8e-24
 Identities = 85/248 (34%), Positives = 121/248 (48%), Gaps = 18/248 (7%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NVN     G+TPL+ AA   H +VV+ LL N A  NVA   G  PL +A  +G   +V
Sbjct: 134 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 193

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             LI+ G        +      ALH AA+   T    VLL+   +P + +    TPL +A
Sbjct: 194 AHLINYG-------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT-EMG 248
           A Y  L V ++LLN   ++        TPLH+A+R G+  +V++LLD G     +T +  
Sbjct: 247 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 306

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTA---------LDTVRELPSQKSQQIA 299
           + LH AA  G   + +ILL  G  +  K  +GL+          LD VR L  Q   +I 
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR-LLLQYDAEID 365

Query: 300 ALIEDHMT 307
            +  DH+T
Sbjct: 366 DITLDHLT 373



 Score =  110 bits (274), Expect = 1e-23
 Identities = 84/256 (32%), Positives = 121/256 (47%), Gaps = 12/256 (4%)

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
           + +LL     PNV+ V     TPLH AA  GH +V + LL+N A  N        PLH A
Sbjct: 453 VKNLLQRGASPNVSNVKVE--TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           A  G   +V+LL+    ++   N       T LH AA+ GH E V  LLE+         
Sbjct: 511 ARIGHTNMVKLLLE---NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 567

Query: 181 KFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAG 238
           K  TPL +AA YG++ V ++LL  +AHPN    N    TPLH+A  + +  +V++LL  G
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 625

Query: 239 MDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQ 297
              +     G + LH AA   + +V + LL  G   N +   G+T L    +     ++ 
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ--EGHAEM 683

Query: 298 IAALIEDHMTGKRSTK 313
           +A L+     G    K
Sbjct: 684 VALLLSKQANGNLGNK 699



 Score =  104 bits (259), Expect = 5e-22
 Identities = 72/217 (33%), Positives = 102/217 (47%), Gaps = 4/217 (1%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  +        TPLH AA NGH  + E+LL + A        G  P+H+AA       
Sbjct: 294 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VRLL+        +++   D+ T LH AA  GH  V KVLL++   P  R     TPL +
Sbjct: 354 VRLLLQYD---AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY-QTEM 247
           A     + V+++LL    ++ +      TPLH+A+  GH  +V+ LL  G   N    ++
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470

Query: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            + LH AA  G T+V + LL     VN K     T L
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507



 Score =  104 bits (259), Expect = 5e-22
 Identities = 90/294 (30%), Positives = 118/294 (40%), Gaps = 68/294 (23%)

Query: 57  SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDA---------LT- 106
           + H   S + +  G  +      G +P+H AA   H D V +LL+ DA         LT 
Sbjct: 315 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374

Query: 107 -----------------------NVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
                                  N     G  PLH+A  K   +++ LL+  G S   V 
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434

Query: 144 E------------------------------QNNDNETALHCAAQYGHTEVVKVLLEELT 173
           E                               N   ET LH AA+ GHTEV K LL+   
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
               +    +TPL  AA  G   +VK+LL  NA+PNL    T  HTPLH+AAR GH   V
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETV 552

Query: 232 QVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             LL+        T+ G + LH AA +GK  V ++LL      N    +GLT L
Sbjct: 553 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 606



 Score =  102 bits (255), Expect = 2e-21
 Identities = 91/308 (29%), Positives = 132/308 (42%), Gaps = 29/308 (9%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH A+  GH  +V  LL  + +      KG   LH+AA  G  ++V
Sbjct: 68  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 127

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           R L++ G     VN Q+    T L+ AAQ  H EVVK LLE   +  +      TPL +A
Sbjct: 128 RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTP-LHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
              G   VV  L+N          K   P LH+AARN       VLL    + +  ++ G
Sbjct: 185 LQQGHENVVAHLIN-----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG 239

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVR--------ELPSQKSQQIA 299
            + LH AA +   +V Q+LL  G  VN    +G+T L             L   +  QI 
Sbjct: 240 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 299

Query: 300 ALIEDHMT--------GKRSTKEV--DKTPPPQPPLISSMDSISQKSQGDVEKAVTELII 349
              +D +T        G     E+  D   P Q    + +  I   +QGD    V  L++
Sbjct: 300 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-RLLL 358

Query: 350 DFDANAEE 357
            +DA  ++
Sbjct: 359 QYDAEIDD 366



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 14/215 (6%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG +VN     G TPLH A+  G+  +V +LL   A           PLH AA  G  +I
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 320

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE---ELTDPTMRNNKFETP 185
             +L+  G     +  +  +  + +H AAQ  H + V++LL+   E+ D T+ +    TP
Sbjct: 321 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH---LTP 374

Query: 186 LDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
           L +AA  G   V K+LL+  A PN  + N    TPLH+A +  H  V+++LL  G   + 
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 432

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKD 277
            TE G + LH A+  G   +V+ LL  G   N+ +
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 59/167 (35%), Positives = 84/167 (50%), Gaps = 7/167 (4%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G + N     G TPLH AA  GH ++V +LL   A  N+ +  G  PLHL A +G   + 
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
            +LI  G     V+       T LH A+ YG+ ++VK LL+   D   +     +PL  A
Sbjct: 718 DVLIKHG---VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 774

Query: 190 ALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVL 234
           A  G  ++V +LL   A PN +S +    TPL +A R G+ +V  VL
Sbjct: 775 AQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAKRLGYISVTDVL 819


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  126 bits (316), Expect = 1e-28
 Identities = 76/216 (35%), Positives = 116/216 (53%), Gaps = 4/216 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G +++ V  +G TPLH A+  GH  +V+ LL+  A  NV++ K   PLH+AA  G  ++ 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + L+    +  +VN +  D++T LHCAA+ GHT +VK+LLE   +P +      TPL +A
Sbjct: 454 KYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG- 248
           A  G +E V  LL    +      K  TPLH+AA+ G   V ++LL+     N   + G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + LH A      D+V++LL  G   +    +G T L
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606



 Score =  117 bits (292), Expect = 8e-26
 Identities = 71/215 (33%), Positives = 110/215 (51%), Gaps = 4/215 (1%)

Query: 71  PNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVR 130
           PN + +  TG+TPLH AA   + +V ++LL   A  N     G  PLH+A+ +G+  +VR
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 131 LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAA 190
           LL+ +G    ++  +  D  T LHCAA+ GH  + ++LL+       +     +P+ +AA
Sbjct: 257 LLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 191 LYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-S 249
               L+ V++LL     +        TPLH+AA  GH  V +VLLD G   N +   G +
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 250 ALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            LH A       V+++LL  G  ++     GLT L
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  116 bits (291), Expect = 1e-25
 Identities = 112/433 (25%), Positives = 175/433 (40%), Gaps = 65/433 (15%)

Query: 75  CVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIH 134
           C+   G+TPLH AA  G   V E+LL  DA  N A   G  PLH+A    +  IV+LL+ 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 135 QG------------PSHTRV------------------NEQNNDNETALHCAAQYGHTEV 164
           +G            P H                     N ++    T LH AAQ GH E+
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 165 VKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAA 223
           V +LL +  +  + N    TPL L A  G + V  +L+  H  ++   T+  +TPLH+A+
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709

Query: 224 RNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLT 282
             G+  +V+ LL    D N +T++G S LH+AA  G TD+V +LL  G   N   + G T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 283 ALDTVRELPSQKSQQIAALIED-----------HMTGKRSTKEV-DKTPPPQPPLISSMD 330
            L   + L       +  ++ D            M+   +  E+ D +      LIS   
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKA 829

Query: 331 SISQKSQGDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKE 390
                   D EK + + +   D   E           I C   +++   RS +Q+  +KE
Sbjct: 830 ERRDSRDVDEEKELLDFVPKLDQVVESPA-----IPRIPCAMPETVVI-RSEEQEQASKE 883

Query: 391 AEAAGVKPAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREE 450
            +   + P+               P  E  D+I     P+    ++S      G + R  
Sbjct: 884 YDEDSLIPSS--------------PATETSDNISPVASPVHTGFLVSFMVDARGGSMRGS 929

Query: 451 DEHPYELLLTAET 463
             +   +++   T
Sbjct: 930 RHNGLRVVIPPRT 942



 Score =  110 bits (275), Expect = 8e-24
 Identities = 85/248 (34%), Positives = 121/248 (48%), Gaps = 18/248 (7%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NVN     G+TPL+ AA   H +VV+ LL N A  NVA   G  PL +A  +G   +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             LI+ G        +      ALH AA+   T    VLL+   +P + +    TPL +A
Sbjct: 161 AHLINYG-------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT-EMG 248
           A Y  L V ++LLN   ++        TPLH+A+R G+  +V++LLD G     +T +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTA---------LDTVRELPSQKSQQIA 299
           + LH AA  G   + +ILL  G  +  K  +GL+          LD VR L  Q   +I 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR-LLLQYDAEID 332

Query: 300 ALIEDHMT 307
            +  DH+T
Sbjct: 333 DITLDHLT 340



 Score =  110 bits (274), Expect = 1e-23
 Identities = 84/256 (32%), Positives = 121/256 (47%), Gaps = 12/256 (4%)

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
           + +LL     PNV+ V     TPLH AA  GH +V + LL+N A  N        PLH A
Sbjct: 420 VKNLLQRGASPNVSNVKVE--TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           A  G   +V+LL+    ++   N       T LH AA+ GH E V  LLE+         
Sbjct: 478 ARIGHTNMVKLLLE---NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 181 KFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAG 238
           K  TPL +AA YG++ V ++LL  +AHPN    N    TPLH+A  + +  +V++LL  G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 592

Query: 239 MDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQ 297
              +     G + LH AA   + +V + LL  G   N +   G+T L    +     ++ 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ--EGHAEM 650

Query: 298 IAALIEDHMTGKRSTK 313
           +A L+     G    K
Sbjct: 651 VALLLSKQANGNLGNK 666



 Score =  104 bits (259), Expect = 5e-22
 Identities = 72/217 (33%), Positives = 102/217 (47%), Gaps = 4/217 (1%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  +        TPLH AA NGH  + E+LL + A        G  P+H+AA       
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VRLL+        +++   D+ T LH AA  GH  V KVLL++   P  R     TPL +
Sbjct: 321 VRLLLQYD---AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY-QTEM 247
           A     + V+++LL    ++ +      TPLH+A+  GH  +V+ LL  G   N    ++
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            + LH AA  G T+V + LL     VN K     T L
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score =  104 bits (259), Expect = 5e-22
 Identities = 90/294 (30%), Positives = 118/294 (40%), Gaps = 68/294 (23%)

Query: 57  SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDA---------LT- 106
           + H   S + +  G  +      G +P+H AA   H D V +LL+ DA         LT 
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 107 -----------------------NVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
                                  N     G  PLH+A  K   +++ LL+  G S   V 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 144 E------------------------------QNNDNETALHCAAQYGHTEVVKVLLEELT 173
           E                               N   ET LH AA+ GHTEV K LL+   
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
               +    +TPL  AA  G   +VK+LL  NA+PNL    T  HTPLH+AAR GH   V
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETV 519

Query: 232 QVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             LL+        T+ G + LH AA +GK  V ++LL      N    +GLT L
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573



 Score =  102 bits (255), Expect = 2e-21
 Identities = 91/308 (29%), Positives = 132/308 (42%), Gaps = 29/308 (9%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH A+  GH  +V  LL  + +      KG   LH+AA  G  ++V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           R L++ G     VN Q+    T L+ AAQ  H EVVK LLE   +  +      TPL +A
Sbjct: 95  RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTP-LHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
              G   VV  L+N          K   P LH+AARN       VLL    + +  ++ G
Sbjct: 152 LQQGHENVVAHLIN-----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG 206

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVR--------ELPSQKSQQIA 299
            + LH AA +   +V Q+LL  G  VN    +G+T L             L   +  QI 
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266

Query: 300 ALIEDHMT--------GKRSTKEV--DKTPPPQPPLISSMDSISQKSQGDVEKAVTELII 349
              +D +T        G     E+  D   P Q    + +  I   +QGD    V  L++
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-RLLL 325

Query: 350 DFDANAEE 357
            +DA  ++
Sbjct: 326 QYDAEIDD 333



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 14/215 (6%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG +VN     G TPLH A+  G+  +V +LL   A           PLH AA  G  +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE---ELTDPTMRNNKFETP 185
             +L+  G     +  +  +  + +H AAQ  H + V++LL+   E+ D T+ +    TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH---LTP 341

Query: 186 LDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
           L +AA  G   V K+LL+  A PN  + N    TPLH+A +  H  V+++LL  G   + 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKD 277
            TE G + LH A+  G   +V+ LL  G   N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  126 bits (316), Expect = 1e-28
 Identities = 76/216 (35%), Positives = 116/216 (53%), Gaps = 4/216 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G +++ V  +G TPLH A+  GH  +V+ LL+  A  NV++ K   PLH+AA  G  ++ 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + L+    +  +VN +  D++T LHCAA+ GHT +VK+LLE   +P +      TPL +A
Sbjct: 454 KYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG- 248
           A  G +E V  LL    +      K  TPLH+AA+ G   V ++LL+     N   + G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + LH A      D+V++LL  G   +    +G T L
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606



 Score =  117 bits (292), Expect = 8e-26
 Identities = 71/215 (33%), Positives = 110/215 (51%), Gaps = 4/215 (1%)

Query: 71  PNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVR 130
           PN + +  TG+TPLH AA   + +V ++LL   A  N     G  PLH+A+ +G+  +VR
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 131 LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAA 190
           LL+ +G    ++  +  D  T LHCAA+ GH  + ++LL+       +     +P+ +AA
Sbjct: 257 LLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 191 LYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-S 249
               L+ V++LL     +        TPLH+AA  GH  V +VLLD G   N +   G +
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 250 ALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            LH A       V+++LL  G  ++     GLT L
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  116 bits (291), Expect = 1e-25
 Identities = 112/433 (25%), Positives = 175/433 (40%), Gaps = 65/433 (15%)

Query: 75  CVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIH 134
           C+   G+TPLH AA  G   V E+LL  DA  N A   G  PLH+A    +  IV+LL+ 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 135 QG------------PSHTRV------------------NEQNNDNETALHCAAQYGHTEV 164
           +G            P H                     N ++    T LH AAQ GH E+
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 165 VKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAA 223
           V +LL +  +  + N    TPL L A  G + V  +L+  H  ++   T+  +TPLH+A+
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709

Query: 224 RNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLT 282
             G+  +V+ LL    D N +T++G S LH+AA  G TD+V +LL  G   N   + G T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 283 ALDTVRELPSQKSQQIAALIED-----------HMTGKRSTKEV-DKTPPPQPPLISSMD 330
            L   + L       +  ++ D            M+   +  E+ D +      LIS   
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKA 829

Query: 331 SISQKSQGDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKE 390
                   D EK + + +   D   E           I C   +++   RS +Q+  +KE
Sbjct: 830 ERRDSRDVDEEKELLDFVPKLDQVVESPA-----IPRIPCAMPETVVI-RSEEQEQASKE 883

Query: 391 AEAAGVKPAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREE 450
            +   + P+               P  E  D+I     P+    ++S      G + R  
Sbjct: 884 YDEDSLIPSS--------------PATETSDNISPVASPVHTGFLVSFMVDARGGSMRGS 929

Query: 451 DEHPYELLLTAET 463
             +   +++   T
Sbjct: 930 RHNGLRVVIPPRT 942



 Score =  110 bits (275), Expect = 8e-24
 Identities = 85/248 (34%), Positives = 121/248 (48%), Gaps = 18/248 (7%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NVN     G+TPL+ AA   H +VV+ LL N A  NVA   G  PL +A  +G   +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             LI+ G        +      ALH AA+   T    VLL+   +P + +    TPL +A
Sbjct: 161 AHLINYG-------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT-EMG 248
           A Y  L V ++LLN   ++        TPLH+A+R G+  +V++LLD G     +T +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTA---------LDTVRELPSQKSQQIA 299
           + LH AA  G   + +ILL  G  +  K  +GL+          LD VR L  Q   +I 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR-LLLQYDAEID 332

Query: 300 ALIEDHMT 307
            +  DH+T
Sbjct: 333 DITLDHLT 340



 Score =  110 bits (274), Expect = 1e-23
 Identities = 84/256 (32%), Positives = 121/256 (47%), Gaps = 12/256 (4%)

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
           + +LL     PNV+ V     TPLH AA  GH +V + LL+N A  N        PLH A
Sbjct: 420 VKNLLQRGASPNVSNVKVE--TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           A  G   +V+LL+    ++   N       T LH AA+ GH E V  LLE+         
Sbjct: 478 ARIGHTNMVKLLLE---NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 181 KFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAG 238
           K  TPL +AA YG++ V ++LL  +AHPN    N    TPLH+A  + +  +V++LL  G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 592

Query: 239 MDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQ 297
              +     G + LH AA   + +V + LL  G   N +   G+T L    +     ++ 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ--EGHAEM 650

Query: 298 IAALIEDHMTGKRSTK 313
           +A L+     G    K
Sbjct: 651 VALLLSKQANGNLGNK 666



 Score =  104 bits (259), Expect = 5e-22
 Identities = 72/217 (33%), Positives = 102/217 (47%), Gaps = 4/217 (1%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  +        TPLH AA NGH  + E+LL + A        G  P+H+AA       
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VRLL+        +++   D+ T LH AA  GH  V KVLL++   P  R     TPL +
Sbjct: 321 VRLLLQYD---AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY-QTEM 247
           A     + V+++LL    ++ +      TPLH+A+  GH  +V+ LL  G   N    ++
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            + LH AA  G T+V + LL     VN K     T L
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score =  104 bits (259), Expect = 5e-22
 Identities = 90/294 (30%), Positives = 118/294 (40%), Gaps = 68/294 (23%)

Query: 57  SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDA---------LT- 106
           + H   S + +  G  +      G +P+H AA   H D V +LL+ DA         LT 
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 107 -----------------------NVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
                                  N     G  PLH+A  K   +++ LL+  G S   V 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 144 E------------------------------QNNDNETALHCAAQYGHTEVVKVLLEELT 173
           E                               N   ET LH AA+ GHTEV K LL+   
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
               +    +TPL  AA  G   +VK+LL  NA+PNL    T  HTPLH+AAR GH   V
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETV 519

Query: 232 QVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             LL+        T+ G + LH AA +GK  V ++LL      N    +GLT L
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573



 Score =  102 bits (255), Expect = 2e-21
 Identities = 91/308 (29%), Positives = 132/308 (42%), Gaps = 29/308 (9%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH A+  GH  +V  LL  + +      KG   LH+AA  G  ++V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           R L++ G     VN Q+    T L+ AAQ  H EVVK LLE   +  +      TPL +A
Sbjct: 95  RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTP-LHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
              G   VV  L+N          K   P LH+AARN       VLL    + +  ++ G
Sbjct: 152 LQQGHENVVAHLIN-----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG 206

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVR--------ELPSQKSQQIA 299
            + LH AA +   +V Q+LL  G  VN    +G+T L             L   +  QI 
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266

Query: 300 ALIEDHMT--------GKRSTKEV--DKTPPPQPPLISSMDSISQKSQGDVEKAVTELII 349
              +D +T        G     E+  D   P Q    + +  I   +QGD    V  L++
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-RLLL 325

Query: 350 DFDANAEE 357
            +DA  ++
Sbjct: 326 QYDAEIDD 333



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 14/215 (6%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG +VN     G TPLH A+  G+  +V +LL   A           PLH AA  G  +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE---ELTDPTMRNNKFETP 185
             +L+  G     +  +  +  + +H AAQ  H + V++LL+   E+ D T+ +    TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH---LTP 341

Query: 186 LDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
           L +AA  G   V K+LL+  A PN  + N    TPLH+A +  H  V+++LL  G   + 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKD 277
            TE G + LH A+  G   +V+ LL  G   N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  126 bits (316), Expect = 1e-28
 Identities = 76/216 (35%), Positives = 116/216 (53%), Gaps = 4/216 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G +++ V  +G TPLH A+  GH  +V+ LL+  A  NV++ K   PLH+AA  G  ++ 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + L+    +  +VN +  D++T LHCAA+ GHT +VK+LLE   +P +      TPL +A
Sbjct: 454 KYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG- 248
           A  G +E V  LL    +      K  TPLH+AA+ G   V ++LL+     N   + G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + LH A      D+V++LL  G   +    +G T L
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606



 Score =  117 bits (292), Expect = 8e-26
 Identities = 71/215 (33%), Positives = 110/215 (51%), Gaps = 4/215 (1%)

Query: 71  PNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVR 130
           PN + +  TG+TPLH AA   + +V ++LL   A  N     G  PLH+A+ +G+  +VR
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 131 LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAA 190
           LL+ +G    ++  +  D  T LHCAA+ GH  + ++LL+       +     +P+ +AA
Sbjct: 257 LLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 191 LYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-S 249
               L+ V++LL     +        TPLH+AA  GH  V +VLLD G   N +   G +
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 250 ALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            LH A       V+++LL  G  ++     GLT L
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  116 bits (291), Expect = 1e-25
 Identities = 112/433 (25%), Positives = 175/433 (40%), Gaps = 65/433 (15%)

Query: 75  CVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIH 134
           C+   G+TPLH AA  G   V E+LL  DA  N A   G  PLH+A    +  IV+LL+ 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 135 QG------------PSHTRV------------------NEQNNDNETALHCAAQYGHTEV 164
           +G            P H                     N ++    T LH AAQ GH E+
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 165 VKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAA 223
           V +LL +  +  + N    TPL L A  G + V  +L+  H  ++   T+  +TPLH+A+
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709

Query: 224 RNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLT 282
             G+  +V+ LL    D N +T++G S LH+AA  G TD+V +LL  G   N   + G T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 283 ALDTVRELPSQKSQQIAALIED-----------HMTGKRSTKEV-DKTPPPQPPLISSMD 330
            L   + L       +  ++ D            M+   +  E+ D +      LIS   
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKA 829

Query: 331 SISQKSQGDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKE 390
                   D EK + + +   D   E           I C   +++   RS +Q+  +KE
Sbjct: 830 ERRDSRDVDEEKELLDFVPKLDQVVESPA-----IPRIPCAMPETVVI-RSEEQEQASKE 883

Query: 391 AEAAGVKPAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREE 450
            +   + P+               P  E  D+I     P+    ++S      G + R  
Sbjct: 884 YDEDSLIPSS--------------PATETSDNISPVASPVHTGFLVSFMVDARGGSMRGS 929

Query: 451 DEHPYELLLTAET 463
             +   +++   T
Sbjct: 930 RHNGLRVVIPPRT 942



 Score =  110 bits (275), Expect = 8e-24
 Identities = 85/248 (34%), Positives = 121/248 (48%), Gaps = 18/248 (7%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NVN     G+TPL+ AA   H +VV+ LL N A  NVA   G  PL +A  +G   +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             LI+ G        +      ALH AA+   T    VLL+   +P + +    TPL +A
Sbjct: 161 AHLINYG-------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT-EMG 248
           A Y  L V ++LLN   ++        TPLH+A+R G+  +V++LLD G     +T +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTA---------LDTVRELPSQKSQQIA 299
           + LH AA  G   + +ILL  G  +  K  +GL+          LD VR L  Q   +I 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR-LLLQYDAEID 332

Query: 300 ALIEDHMT 307
            +  DH+T
Sbjct: 333 DITLDHLT 340



 Score =  110 bits (274), Expect = 1e-23
 Identities = 84/256 (32%), Positives = 121/256 (47%), Gaps = 12/256 (4%)

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
           + +LL     PNV+ V     TPLH AA  GH +V + LL+N A  N        PLH A
Sbjct: 420 VKNLLQRGASPNVSNVKVE--TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           A  G   +V+LL+    ++   N       T LH AA+ GH E V  LLE+         
Sbjct: 478 ARIGHTNMVKLLLE---NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 181 KFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAG 238
           K  TPL +AA YG++ V ++LL  +AHPN    N    TPLH+A  + +  +V++LL  G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 592

Query: 239 MDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQ 297
              +     G + LH AA   + +V + LL  G   N +   G+T L    +     ++ 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ--EGHAEM 650

Query: 298 IAALIEDHMTGKRSTK 313
           +A L+     G    K
Sbjct: 651 VALLLSKQANGNLGNK 666



 Score =  104 bits (259), Expect = 5e-22
 Identities = 72/217 (33%), Positives = 102/217 (47%), Gaps = 4/217 (1%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  +        TPLH AA NGH  + E+LL + A        G  P+H+AA       
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VRLL+        +++   D+ T LH AA  GH  V KVLL++   P  R     TPL +
Sbjct: 321 VRLLLQYD---AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY-QTEM 247
           A     + V+++LL    ++ +      TPLH+A+  GH  +V+ LL  G   N    ++
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            + LH AA  G T+V + LL     VN K     T L
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score =  104 bits (259), Expect = 5e-22
 Identities = 90/294 (30%), Positives = 118/294 (40%), Gaps = 68/294 (23%)

Query: 57  SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDA---------LT- 106
           + H   S + +  G  +      G +P+H AA   H D V +LL+ DA         LT 
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 107 -----------------------NVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
                                  N     G  PLH+A  K   +++ LL+  G S   V 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 144 E------------------------------QNNDNETALHCAAQYGHTEVVKVLLEELT 173
           E                               N   ET LH AA+ GHTEV K LL+   
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
               +    +TPL  AA  G   +VK+LL  NA+PNL    T  HTPLH+AAR GH   V
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETV 519

Query: 232 QVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             LL+        T+ G + LH AA +GK  V ++LL      N    +GLT L
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573



 Score =  102 bits (255), Expect = 2e-21
 Identities = 91/308 (29%), Positives = 132/308 (42%), Gaps = 29/308 (9%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH A+  GH  +V  LL  + +      KG   LH+AA  G  ++V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           R L++ G     VN Q+    T L+ AAQ  H EVVK LLE   +  +      TPL +A
Sbjct: 95  RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTP-LHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
              G   VV  L+N          K   P LH+AARN       VLL    + +  ++ G
Sbjct: 152 LQQGHENVVAHLIN-----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG 206

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVR--------ELPSQKSQQIA 299
            + LH AA +   +V Q+LL  G  VN    +G+T L             L   +  QI 
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266

Query: 300 ALIEDHMT--------GKRSTKEV--DKTPPPQPPLISSMDSISQKSQGDVEKAVTELII 349
              +D +T        G     E+  D   P Q    + +  I   +QGD    V  L++
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-RLLL 325

Query: 350 DFDANAEE 357
            +DA  ++
Sbjct: 326 QYDAEIDD 333



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 14/215 (6%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG +VN     G TPLH A+  G+  +V +LL   A           PLH AA  G  +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE---ELTDPTMRNNKFETP 185
             +L+  G     +  +  +  + +H AAQ  H + V++LL+   E+ D T+ +    TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH---LTP 341

Query: 186 LDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
           L +AA  G   V K+LL+  A PN  + N    TPLH+A +  H  V+++LL  G   + 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKD 277
            TE G + LH A+  G   +V+ LL  G   N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  126 bits (316), Expect = 1e-28
 Identities = 76/216 (35%), Positives = 116/216 (53%), Gaps = 4/216 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G +++ V  +G TPLH A+  GH  +V+ LL+  A  NV++ K   PLH+AA  G  ++ 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + L+    +  +VN +  D++T LHCAA+ GHT +VK+LLE   +P +      TPL +A
Sbjct: 454 KYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG- 248
           A  G +E V  LL    +      K  TPLH+AA+ G   V ++LL+     N   + G 
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + LH A      D+V++LL  G   +    +G T L
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606



 Score =  117 bits (292), Expect = 8e-26
 Identities = 71/215 (33%), Positives = 110/215 (51%), Gaps = 4/215 (1%)

Query: 71  PNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVR 130
           PN + +  TG+TPLH AA   + +V ++LL   A  N     G  PLH+A+ +G+  +VR
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256

Query: 131 LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAA 190
           LL+ +G    ++  +  D  T LHCAA+ GH  + ++LL+       +     +P+ +AA
Sbjct: 257 LLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 191 LYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-S 249
               L+ V++LL     +        TPLH+AA  GH  V +VLLD G   N +   G +
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 250 ALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            LH A       V+++LL  G  ++     GLT L
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  116 bits (291), Expect = 1e-25
 Identities = 112/433 (25%), Positives = 175/433 (40%), Gaps = 65/433 (15%)

Query: 75  CVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIH 134
           C+   G+TPLH AA  G   V E+LL  DA  N A   G  PLH+A    +  IV+LL+ 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 135 QG------------PSHTRV------------------NEQNNDNETALHCAAQYGHTEV 164
           +G            P H                     N ++    T LH AAQ GH E+
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 165 VKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAA 223
           V +LL +  +  + N    TPL L A  G + V  +L+  H  ++   T+  +TPLH+A+
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVAS 709

Query: 224 RNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLT 282
             G+  +V+ LL    D N +T++G S LH+AA  G TD+V +LL  G   N   + G T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769

Query: 283 ALDTVRELPSQKSQQIAALIED-----------HMTGKRSTKEV-DKTPPPQPPLISSMD 330
            L   + L       +  ++ D            M+   +  E+ D +      LIS   
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKA 829

Query: 331 SISQKSQGDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKE 390
                   D EK + + +   D   E           I C   +++   RS +Q+  +KE
Sbjct: 830 ERRDSRDVDEEKELLDFVPKLDQVVESPA-----IPRIPCAMPETVVI-RSEEQEQASKE 883

Query: 391 AEAAGVKPAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREE 450
            +   + P+               P  E  D+I     P+    ++S      G + R  
Sbjct: 884 YDEDSLIPSS--------------PATETSDNISPVASPVHTGFLVSFMVDARGGSMRGS 929

Query: 451 DEHPYELLLTAET 463
             +   +++   T
Sbjct: 930 RHNGLRVVIPPRT 942



 Score =  110 bits (275), Expect = 8e-24
 Identities = 85/248 (34%), Positives = 121/248 (48%), Gaps = 18/248 (7%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NVN     G+TPL+ AA   H +VV+ LL N A  NVA   G  PL +A  +G   +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             LI+ G        +      ALH AA+   T    VLL+   +P + +    TPL +A
Sbjct: 161 AHLINYG-------TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT-EMG 248
           A Y  L V ++LLN   ++        TPLH+A+R G+  +V++LLD G     +T +  
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273

Query: 249 SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTA---------LDTVRELPSQKSQQIA 299
           + LH AA  G   + +ILL  G  +  K  +GL+          LD VR L  Q   +I 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR-LLLQYDAEID 332

Query: 300 ALIEDHMT 307
            +  DH+T
Sbjct: 333 DITLDHLT 340



 Score =  110 bits (274), Expect = 1e-23
 Identities = 84/256 (32%), Positives = 121/256 (47%), Gaps = 12/256 (4%)

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
           + +LL     PNV+ V     TPLH AA  GH +V + LL+N A  N        PLH A
Sbjct: 420 VKNLLQRGASPNVSNVKVE--TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           A  G   +V+LL+    ++   N       T LH AA+ GH E V  LLE+         
Sbjct: 478 ARIGHTNMVKLLLE---NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 181 KFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAG 238
           K  TPL +AA YG++ V ++LL  +AHPN    N    TPLH+A  + +  +V++LL  G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 592

Query: 239 MDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQ 297
              +     G + LH AA   + +V + LL  G   N +   G+T L    +     ++ 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ--EGHAEM 650

Query: 298 IAALIEDHMTGKRSTK 313
           +A L+     G    K
Sbjct: 651 VALLLSKQANGNLGNK 666



 Score =  104 bits (259), Expect = 5e-22
 Identities = 72/217 (33%), Positives = 102/217 (47%), Gaps = 4/217 (1%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  +        TPLH AA NGH  + E+LL + A        G  P+H+AA       
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VRLL+        +++   D+ T LH AA  GH  V KVLL++   P  R     TPL +
Sbjct: 321 VRLLLQYD---AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY-QTEM 247
           A     + V+++LL    ++ +      TPLH+A+  GH  +V+ LL  G   N    ++
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            + LH AA  G T+V + LL     VN K     T L
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score =  104 bits (259), Expect = 5e-22
 Identities = 90/294 (30%), Positives = 118/294 (40%), Gaps = 68/294 (23%)

Query: 57  SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDA---------LT- 106
           + H   S + +  G  +      G +P+H AA   H D V +LL+ DA         LT 
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 107 -----------------------NVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
                                  N     G  PLH+A  K   +++ LL+  G S   V 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 144 E------------------------------QNNDNETALHCAAQYGHTEVVKVLLEELT 173
           E                               N   ET LH AA+ GHTEV K LL+   
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
               +    +TPL  AA  G   +VK+LL  NA+PNL    T  HTPLH+AAR GH   V
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETV 519

Query: 232 QVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             LL+        T+ G + LH AA +GK  V ++LL      N    +GLT L
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573



 Score =  102 bits (255), Expect = 2e-21
 Identities = 91/308 (29%), Positives = 132/308 (42%), Gaps = 29/308 (9%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH A+  GH  +V  LL  + +      KG   LH+AA  G  ++V
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           R L++ G     VN Q+    T L+ AAQ  H EVVK LLE   +  +      TPL +A
Sbjct: 95  RELVNYG---ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTP-LHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
              G   VV  L+N          K   P LH+AARN       VLL    + +  ++ G
Sbjct: 152 LQQGHENVVAHLIN-----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTG 206

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVR--------ELPSQKSQQIA 299
            + LH AA +   +V Q+LL  G  VN    +G+T L             L   +  QI 
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266

Query: 300 ALIEDHMT--------GKRSTKEV--DKTPPPQPPLISSMDSISQKSQGDVEKAVTELII 349
              +D +T        G     E+  D   P Q    + +  I   +QGD    V  L++
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-RLLL 325

Query: 350 DFDANAEE 357
            +DA  ++
Sbjct: 326 QYDAEIDD 333



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 71/215 (33%), Positives = 107/215 (49%), Gaps = 14/215 (6%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG +VN     G TPLH A+  G+  +V +LL   A           PLH AA  G  +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE---ELTDPTMRNNKFETP 185
             +L+  G     +  +  +  + +H AAQ  H + V++LL+   E+ D T+ +    TP
Sbjct: 288 SEILLDHG---APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH---LTP 341

Query: 186 LDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
           L +AA  G   V K+LL+  A PN  + N    TPLH+A +  H  V+++LL  G   + 
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKD 277
            TE G + LH A+  G   +V+ LL  G   N+ +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  125 bits (315), Expect = 2e-28
 Identities = 89/259 (34%), Positives = 131/259 (50%), Gaps = 13/259 (5%)

Query: 64  LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
           LL     PN   ++  G+TPLH A       V+E+L++  A        G  P+H+AA+ 
Sbjct: 363 LLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420

Query: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFE 183
           G   IV LL+  G S    N +    ETALH AA+ G  EVV+ LL        R  + +
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 477

Query: 184 TPLDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
           TPL +A+  G+ E+V++LL   AHP+  +  T  +TPLH++AR G   V  VLL+AG   
Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMAHPD--AATTNGYTPLHISAREGQVDVASVLLEAGAAH 535

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA 300
           +  T+ G + LH AA +G  DV ++LL      +    +GLT L       +QK   +A 
Sbjct: 536 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK---VAL 592

Query: 301 LIEDHMTGKRSTKEVDKTP 319
           L+ +      +T +   TP
Sbjct: 593 LLLEKGASPHATAKNGYTP 611



 Score =  113 bits (283), Expect = 9e-25
 Identities = 82/240 (34%), Positives = 119/240 (49%), Gaps = 9/240 (3%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  ++     G TPLH AA +GH  VVE+LL   A        G  PLH+AA     + 
Sbjct: 267 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 326

Query: 129 VR-LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLD 187
           V+ LL H+ P    V++   D  TALH AA  GH  V K+LL++  +P  R     TPL 
Sbjct: 327 VKHLLQHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 382

Query: 188 LAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEM 247
           +A    R++V+++L+    ++ +      TP+H+AA  GH  +V +LL  G   +     
Sbjct: 383 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 442

Query: 248 G-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHM 306
           G +ALH AA  G+ +VV+ LL  G  V+ +     T L     L      +I  L+  HM
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL---GKTEIVQLLLQHM 499



 Score =  112 bits (280), Expect = 2e-24
 Identities = 70/239 (29%), Positives = 124/239 (51%), Gaps = 7/239 (2%)

Query: 82  TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
           TPLH A+  G  ++V++LL++ A  + A + G  PLH++A +G   +  +L+  G +H+ 
Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 537

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKML 201
             ++     T LH AA+YG  +V K+LL+             TPL +AA Y   +V  +L
Sbjct: 538 ATKKGF---TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594

Query: 202 LNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKT 260
           L    +  +     +TPLH+AA+     +   LL+ G ++N  T+ G + LH A+  G T
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654

Query: 261 DVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTP 319
           D+V +LL  G ++++    GLT+L    +   +    +A ++  H   + +  ++  TP
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQ---EDKVNVADILTKHGADQDAHTKLGYTP 710



 Score =  109 bits (273), Expect = 1e-23
 Identities = 83/289 (28%), Positives = 126/289 (43%), Gaps = 20/289 (6%)

Query: 63  SLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAW 122
           +LL + +G + +     GYTPLH AA      +   LL   A TN+   +G  PLHLA+ 
Sbjct: 591 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650

Query: 123 KGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
           +G   +V LL+ +G +   ++       T+LH AAQ     V  +L +   D        
Sbjct: 651 EGHTDMVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707

Query: 183 ETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSN 242
            TPL +A  YG +++V  LL    N+ +     +TPLH AA+ GH  ++ VLL  G   N
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767

Query: 243 YQTEMG-SALHEAALFGKTDVVQILLAAGTDV-----NIKDNHGLTALDTVRELPSQKSQ 296
             T  G +AL  A   G   VV  L     +V      I + H L   +T+ E+     +
Sbjct: 768 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDE 827

Query: 297 QIAALIEDHMTG-------KRSTKEVDKTPPPQPPLISSMDSISQKSQG 338
           +     +D MTG           KE+     P    +  M+ +    +G
Sbjct: 828 E----GDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 872



 Score =  103 bits (257), Expect = 9e-22
 Identities = 87/284 (30%), Positives = 132/284 (46%), Gaps = 27/284 (9%)

Query: 10  AARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMWR 69
           AA+ GH+  V++LL         G G    S    G +      L   +  +  L+    
Sbjct: 50  AAKEGHVGLVQELL---------GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK--E 98

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G N+N     G+TPL+ AA   H DVV+ LL N A  + A   G  PL +A  +G  Q V
Sbjct: 99  GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 158

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE-----ELTDPTMRNNKFE- 183
            +L+         + +      ALH AA+   T+   +LL+     ++    M N   E 
Sbjct: 159 AILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES 211

Query: 184 --TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
             TPL +AA YG + V  +LLN    +        TPLH+A++ G+  +V++LLD G   
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + +T  G + LH AA  G   VV++LL  G  +  +  +GL+ L
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 75/228 (32%), Positives = 110/228 (48%), Gaps = 6/228 (2%)

Query: 65  LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
           L + R    +     G TPLH AA   ++ V  +LL   A  +     G  PLH+AA K 
Sbjct: 560 LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 619

Query: 125 DAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFET 184
             QI   L++ G     V +Q     T LH A+Q GHT++V +LL++  +  M      T
Sbjct: 620 QMQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 676

Query: 185 PLDLAALYGRLEVVKMLLNAHPNLLSCNTK-KHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
            L LAA   ++ V   +L  H      +TK  +TPL +A   G+  +V  LL  G + N 
Sbjct: 677 SLHLAAQEDKVNVAD-ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVREL 290
           +T+ G + LH+AA  G T ++ +LL  G   N    +G TAL   + L
Sbjct: 736 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 783



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 74/253 (29%), Positives = 114/253 (45%), Gaps = 41/253 (16%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH AA  GH  +V+ LL   +  + A  KG   LH+A+  G A++V
Sbjct: 33  GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 92

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           ++L+ +G     +N Q+ +  T L+ AAQ  H +VVK LLE   + +       TPL +A
Sbjct: 93  KVLVKEG---ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149

Query: 190 ALYGRLEVVKMLLN-----------AHPNLLSCNTKK----------------------- 215
              G  + V +LL             H      +TK                        
Sbjct: 150 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 209

Query: 216 ---HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGT 271
               TPLH+AA  G+  V  +LL+ G   ++    G + LH A+  G T++V++LL  G 
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 269

Query: 272 DVNIKDNHGLTAL 284
            ++ K   GLT L
Sbjct: 270 QIDAKTRDGLTPL 282



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 70/236 (29%), Positives = 101/236 (42%), Gaps = 41/236 (17%)

Query: 87  AALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQN 146
           AA  G+ D V   L+     N  +  G   LHLAA +G   +V+ L+ +G S   V+   
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSAT 73

Query: 147 NDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHP 206
               TALH A+  G  EVVKVL++E  +   ++    TPL +AA    ++VVK LL    
Sbjct: 74  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133

Query: 207 NLLSCNTKKHTPLHLAARNGHKAVVQVLLD------------------------------ 236
           N  +      TPL +A + GH   V +LL+                              
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 193

Query: 237 -------AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
                  + M  N  TE G + LH AA +G  +V  +LL  G  V+    +G+T L
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 249



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 57/178 (32%), Positives = 85/178 (47%), Gaps = 6/178 (3%)

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKML 201
           +N  N +   ALH AA+ GH  +V+ LL   +       K  T L +A+L G+ EVVK+L
Sbjct: 36  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95

Query: 202 LNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKT 260
           +    N+ + +    TPL++AA+  H  VV+ LL+ G + +  TE G + L  A   G  
Sbjct: 96  VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155

Query: 261 DVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKT 318
             V ILL   T   ++    L AL         KS  +  L  DH    +S   V++T
Sbjct: 156 QAVAILLENDTKGKVR----LPALHIAARKDDTKSAAL-LLQNDHNADVQSKMMVNRT 208



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 51/166 (30%), Positives = 80/166 (48%), Gaps = 3/166 (1%)

Query: 145 QNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNA 204
           Q +D+  +   AA+ G+ + V   L+   D    N      L LAA  G + +V+ LL  
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65

Query: 205 HPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVV 263
             ++ S   K +T LH+A+  G   VV+VL+  G + N Q++ G + L+ AA     DVV
Sbjct: 66  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 264 QILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGK 309
           + LL  G + +     G T L     L    +Q +A L+E+   GK
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVA--LQQGHNQAVAILLENDTKGK 169


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  125 bits (315), Expect = 2e-28
 Identities = 89/259 (34%), Positives = 131/259 (50%), Gaps = 13/259 (5%)

Query: 64  LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
           LL     PN   ++  G+TPLH A       V+E+L++  A        G  P+H+AA+ 
Sbjct: 384 LLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFE 183
           G   IV LL+  G S    N +    ETALH AA+ G  EVV+ LL        R  + +
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498

Query: 184 TPLDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
           TPL +A+  G+ E+V++LL   AHP+  +  T  +TPLH++AR G   V  VLL+AG   
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPD--AATTNGYTPLHISAREGQVDVASVLLEAGAAH 556

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA 300
           +  T+ G + LH AA +G  DV ++LL      +    +GLT L       +QK   +A 
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK---VAL 613

Query: 301 LIEDHMTGKRSTKEVDKTP 319
           L+ +      +T +   TP
Sbjct: 614 LLLEKGASPHATAKNGYTP 632



 Score =  113 bits (283), Expect = 9e-25
 Identities = 82/240 (34%), Positives = 119/240 (49%), Gaps = 9/240 (3%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  ++     G TPLH AA +GH  VVE+LL   A        G  PLH+AA     + 
Sbjct: 288 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347

Query: 129 VR-LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLD 187
           V+ LL H+ P    V++   D  TALH AA  GH  V K+LL++  +P  R     TPL 
Sbjct: 348 VKHLLQHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403

Query: 188 LAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEM 247
           +A    R++V+++L+    ++ +      TP+H+AA  GH  +V +LL  G   +     
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463

Query: 248 G-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHM 306
           G +ALH AA  G+ +VV+ LL  G  V+ +     T L     L      +I  L+  HM
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL---GKTEIVQLLLQHM 520



 Score =  112 bits (280), Expect = 2e-24
 Identities = 70/239 (29%), Positives = 124/239 (51%), Gaps = 7/239 (2%)

Query: 82  TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
           TPLH A+  G  ++V++LL++ A  + A + G  PLH++A +G   +  +L+  G +H+ 
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKML 201
             ++     T LH AA+YG  +V K+LL+             TPL +AA Y   +V  +L
Sbjct: 559 ATKKGF---TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 202 LNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKT 260
           L    +  +     +TPLH+AA+     +   LL+ G ++N  T+ G + LH A+  G T
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675

Query: 261 DVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTP 319
           D+V +LL  G ++++    GLT+L    +   +    +A ++  H   + +  ++  TP
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQ---EDKVNVADILTKHGADQDAHTKLGYTP 731



 Score =  109 bits (273), Expect = 1e-23
 Identities = 83/289 (28%), Positives = 126/289 (43%), Gaps = 20/289 (6%)

Query: 63  SLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAW 122
           +LL + +G + +     GYTPLH AA      +   LL   A TN+   +G  PLHLA+ 
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 123 KGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
           +G   +V LL+ +G +   ++       T+LH AAQ     V  +L +   D        
Sbjct: 672 EGHTDMVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728

Query: 183 ETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSN 242
            TPL +A  YG +++V  LL    N+ +     +TPLH AA+ GH  ++ VLL  G   N
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788

Query: 243 YQTEMG-SALHEAALFGKTDVVQILLAAGTDV-----NIKDNHGLTALDTVRELPSQKSQ 296
             T  G +AL  A   G   VV  L     +V      I + H L   +T+ E+     +
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDE 848

Query: 297 QIAALIEDHMTG-------KRSTKEVDKTPPPQPPLISSMDSISQKSQG 338
           +     +D MTG           KE+     P    +  M+ +    +G
Sbjct: 849 E----GDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893



 Score =  103 bits (257), Expect = 9e-22
 Identities = 87/284 (30%), Positives = 132/284 (46%), Gaps = 27/284 (9%)

Query: 10  AARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMWR 69
           AA+ GH+  V++LL         G G    S    G +      L   +  +  L+    
Sbjct: 71  AAKEGHVGLVQELL---------GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK--E 119

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G N+N     G+TPL+ AA   H DVV+ LL N A  + A   G  PL +A  +G  Q V
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE-----ELTDPTMRNNKFE- 183
            +L+         + +      ALH AA+   T+   +LL+     ++    M N   E 
Sbjct: 180 AILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES 232

Query: 184 --TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
             TPL +AA YG + V  +LLN    +        TPLH+A++ G+  +V++LLD G   
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + +T  G + LH AA  G   VV++LL  G  +  +  +GL+ L
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 75/228 (32%), Positives = 110/228 (48%), Gaps = 6/228 (2%)

Query: 65  LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
           L + R    +     G TPLH AA   ++ V  +LL   A  +     G  PLH+AA K 
Sbjct: 581 LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640

Query: 125 DAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFET 184
             QI   L++ G     V +Q     T LH A+Q GHT++V +LL++  +  M      T
Sbjct: 641 QMQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 697

Query: 185 PLDLAALYGRLEVVKMLLNAHPNLLSCNTK-KHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
            L LAA   ++ V   +L  H      +TK  +TPL +A   G+  +V  LL  G + N 
Sbjct: 698 SLHLAAQEDKVNVAD-ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVREL 290
           +T+ G + LH+AA  G T ++ +LL  G   N    +G TAL   + L
Sbjct: 757 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 74/253 (29%), Positives = 114/253 (45%), Gaps = 41/253 (16%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH AA  GH  +V+ LL   +  + A  KG   LH+A+  G A++V
Sbjct: 54  GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           ++L+ +G     +N Q+ +  T L+ AAQ  H +VVK LLE   + +       TPL +A
Sbjct: 114 KVLVKEG---ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170

Query: 190 ALYGRLEVVKMLLN-----------AHPNLLSCNTKK----------------------- 215
              G  + V +LL             H      +TK                        
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230

Query: 216 ---HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGT 271
               TPLH+AA  G+  V  +LL+ G   ++    G + LH A+  G T++V++LL  G 
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290

Query: 272 DVNIKDNHGLTAL 284
            ++ K   GLT L
Sbjct: 291 QIDAKTRDGLTPL 303



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 70/236 (29%), Positives = 101/236 (42%), Gaps = 41/236 (17%)

Query: 87  AALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQN 146
           AA  G+ D V   L+     N  +  G   LHLAA +G   +V+ L+ +G S   V+   
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSAT 94

Query: 147 NDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHP 206
               TALH A+  G  EVVKVL++E  +   ++    TPL +AA    ++VVK LL    
Sbjct: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 207 NLLSCNTKKHTPLHLAARNGHKAVVQVLLD------------------------------ 236
           N  +      TPL +A + GH   V +LL+                              
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214

Query: 237 -------AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
                  + M  N  TE G + LH AA +G  +V  +LL  G  V+    +G+T L
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 57/178 (32%), Positives = 85/178 (47%), Gaps = 6/178 (3%)

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKML 201
           +N  N +   ALH AA+ GH  +V+ LL   +       K  T L +A+L G+ EVVK+L
Sbjct: 57  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 202 LNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKT 260
           +    N+ + +    TPL++AA+  H  VV+ LL+ G + +  TE G + L  A   G  
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 261 DVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKT 318
             V ILL   T   ++    L AL         KS  +  L  DH    +S   V++T
Sbjct: 177 QAVAILLENDTKGKVR----LPALHIAARKDDTKSAAL-LLQNDHNADVQSKMMVNRT 229



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 53/175 (30%), Positives = 83/175 (47%), Gaps = 3/175 (1%)

Query: 136 GPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRL 195
           G S  R   + +D+  +   AA+ G+ + V   L+   D    N      L LAA  G +
Sbjct: 18  GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHV 77

Query: 196 EVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEA 254
            +V+ LL    ++ S   K +T LH+A+  G   VV+VL+  G + N Q++ G + L+ A
Sbjct: 78  GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137

Query: 255 ALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGK 309
           A     DVV+ LL  G + +     G T L     L    +Q +A L+E+   GK
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVA--LQQGHNQAVAILLENDTKGK 190


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  125 bits (315), Expect = 2e-28
 Identities = 89/259 (34%), Positives = 131/259 (50%), Gaps = 13/259 (5%)

Query: 64  LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
           LL     PN   ++  G+TPLH A       V+E+L++  A        G  P+H+AA+ 
Sbjct: 384 LLDKRANPNARALN--GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFE 183
           G   IV LL+  G S    N +    ETALH AA+ G  EVV+ LL        R  + +
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRG---ETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498

Query: 184 TPLDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
           TPL +A+  G+ E+V++LL   AHP+  +  T  +TPLH++AR G   V  VLL+AG   
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPD--AATTNGYTPLHISAREGQVDVASVLLEAGAAH 556

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA 300
           +  T+ G + LH AA +G  DV ++LL      +    +GLT L       +QK   +A 
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK---VAL 613

Query: 301 LIEDHMTGKRSTKEVDKTP 319
           L+ +      +T +   TP
Sbjct: 614 LLLEKGASPHATAKNGYTP 632



 Score =  113 bits (283), Expect = 9e-25
 Identities = 82/240 (34%), Positives = 119/240 (49%), Gaps = 9/240 (3%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  ++     G TPLH AA +GH  VVE+LL   A        G  PLH+AA     + 
Sbjct: 288 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347

Query: 129 VR-LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLD 187
           V+ LL H+ P    V++   D  TALH AA  GH  V K+LL++  +P  R     TPL 
Sbjct: 348 VKHLLQHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403

Query: 188 LAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEM 247
           +A    R++V+++L+    ++ +      TP+H+AA  GH  +V +LL  G   +     
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463

Query: 248 G-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHM 306
           G +ALH AA  G+ +VV+ LL  G  V+ +     T L     L      +I  L+  HM
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL---GKTEIVQLLLQHM 520



 Score =  112 bits (280), Expect = 2e-24
 Identities = 70/239 (29%), Positives = 124/239 (51%), Gaps = 7/239 (2%)

Query: 82  TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
           TPLH A+  G  ++V++LL++ A  + A + G  PLH++A +G   +  +L+  G +H+ 
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKML 201
             ++     T LH AA+YG  +V K+LL+             TPL +AA Y   +V  +L
Sbjct: 559 ATKKGF---TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 202 LNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKT 260
           L    +  +     +TPLH+AA+     +   LL+ G ++N  T+ G + LH A+  G T
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675

Query: 261 DVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTP 319
           D+V +LL  G ++++    GLT+L    +   +    +A ++  H   + +  ++  TP
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQ---EDKVNVADILTKHGADQDAHTKLGYTP 731



 Score =  109 bits (273), Expect = 1e-23
 Identities = 83/289 (28%), Positives = 126/289 (43%), Gaps = 20/289 (6%)

Query: 63  SLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAW 122
           +LL + +G + +     GYTPLH AA      +   LL   A TN+   +G  PLHLA+ 
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 123 KGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
           +G   +V LL+ +G +   ++       T+LH AAQ     V  +L +   D        
Sbjct: 672 EGHTDMVTLLLDKGAN---IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728

Query: 183 ETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSN 242
            TPL +A  YG +++V  LL    N+ +     +TPLH AA+ GH  ++ VLL  G   N
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788

Query: 243 YQTEMG-SALHEAALFGKTDVVQILLAAGTDV-----NIKDNHGLTALDTVRELPSQKSQ 296
             T  G +AL  A   G   VV  L     +V      I + H L   +T+ E+     +
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDE 848

Query: 297 QIAALIEDHMTG-------KRSTKEVDKTPPPQPPLISSMDSISQKSQG 338
           +     +D MTG           KE+     P    +  M+ +    +G
Sbjct: 849 E----GDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893



 Score =  103 bits (257), Expect = 9e-22
 Identities = 87/284 (30%), Positives = 132/284 (46%), Gaps = 27/284 (9%)

Query: 10  AARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMWR 69
           AA+ GH+  V++LL         G G    S    G +      L   +  +  L+    
Sbjct: 71  AAKEGHVGLVQELL---------GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK--E 119

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G N+N     G+TPL+ AA   H DVV+ LL N A  + A   G  PL +A  +G  Q V
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLE-----ELTDPTMRNNKFE- 183
            +L+         + +      ALH AA+   T+   +LL+     ++    M N   E 
Sbjct: 180 AILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES 232

Query: 184 --TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
             TPL +AA YG + V  +LLN    +        TPLH+A++ G+  +V++LLD G   
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 242 NYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           + +T  G + LH AA  G   VV++LL  G  +  +  +GL+ L
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 75/228 (32%), Positives = 110/228 (48%), Gaps = 6/228 (2%)

Query: 65  LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
           L + R    +     G TPLH AA   ++ V  +LL   A  +     G  PLH+AA K 
Sbjct: 581 LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640

Query: 125 DAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFET 184
             QI   L++ G     V +Q     T LH A+Q GHT++V +LL++  +  M      T
Sbjct: 641 QMQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 697

Query: 185 PLDLAALYGRLEVVKMLLNAHPNLLSCNTK-KHTPLHLAARNGHKAVVQVLLDAGMDSNY 243
            L LAA   ++ V   +L  H      +TK  +TPL +A   G+  +V  LL  G + N 
Sbjct: 698 SLHLAAQEDKVNVAD-ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVREL 290
           +T+ G + LH+AA  G T ++ +LL  G   N    +G TAL   + L
Sbjct: 757 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 74/253 (29%), Positives = 114/253 (45%), Gaps = 41/253 (16%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++N  +  G   LH AA  GH  +V+ LL   +  + A  KG   LH+A+  G A++V
Sbjct: 54  GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           ++L+ +G     +N Q+ +  T L+ AAQ  H +VVK LLE   + +       TPL +A
Sbjct: 114 KVLVKEG---ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170

Query: 190 ALYGRLEVVKMLLN-----------AHPNLLSCNTKK----------------------- 215
              G  + V +LL             H      +TK                        
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230

Query: 216 ---HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGT 271
               TPLH+AA  G+  V  +LL+ G   ++    G + LH A+  G T++V++LL  G 
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290

Query: 272 DVNIKDNHGLTAL 284
            ++ K   GLT L
Sbjct: 291 QIDAKTRDGLTPL 303



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 70/236 (29%), Positives = 101/236 (42%), Gaps = 41/236 (17%)

Query: 87  AALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQN 146
           AA  G+ D V   L+     N  +  G   LHLAA +G   +V+ L+ +G S   V+   
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSAT 94

Query: 147 NDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHP 206
               TALH A+  G  EVVKVL++E  +   ++    TPL +AA    ++VVK LL    
Sbjct: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 207 NLLSCNTKKHTPLHLAARNGHKAVVQVLLD------------------------------ 236
           N  +      TPL +A + GH   V +LL+                              
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214

Query: 237 -------AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
                  + M  N  TE G + LH AA +G  +V  +LL  G  V+    +G+T L
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 57/178 (32%), Positives = 85/178 (47%), Gaps = 6/178 (3%)

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKML 201
           +N  N +   ALH AA+ GH  +V+ LL   +       K  T L +A+L G+ EVVK+L
Sbjct: 57  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 202 LNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKT 260
           +    N+ + +    TPL++AA+  H  VV+ LL+ G + +  TE G + L  A   G  
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 261 DVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKT 318
             V ILL   T   ++    L AL         KS  +  L  DH    +S   V++T
Sbjct: 177 QAVAILLENDTKGKVR----LPALHIAARKDDTKSAAL-LLQNDHNADVQSKMMVNRT 229



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 53/175 (30%), Positives = 83/175 (47%), Gaps = 3/175 (1%)

Query: 136 GPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRL 195
           G S  R   + +D+  +   AA+ G+ + V   L+   D    N      L LAA  G +
Sbjct: 18  GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHV 77

Query: 196 EVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEA 254
            +V+ LL    ++ S   K +T LH+A+  G   VV+VL+  G + N Q++ G + L+ A
Sbjct: 78  GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137

Query: 255 ALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGK 309
           A     DVV+ LL  G + +     G T L     L    +Q +A L+E+   GK
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVA--LQQGHNQAVAILLENDTKGK 190


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  117 bits (294), Expect = 5e-26
 Identities = 82/217 (37%), Positives = 113/217 (52%), Gaps = 6/217 (2%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  VN  DS   TPLH A  +  ++ V+VLL++ A  N  D     PLH+AA     +  
Sbjct: 64  GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCA 123

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             L+   P  + VN  +    TALH AA  GH E+VK+LL    +    + K    +  A
Sbjct: 124 EALV---PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           A  G +EVVK+L++ H   ++C  KK +TPLH AA +G  +VV+ LLD G+D N     G
Sbjct: 181 AYMGHIEVVKLLVS-HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239

Query: 249 SA-LHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           +  LH A   G+  VV  L+  G  VN K+  G T L
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276



 Score =  114 bits (284), Expect = 7e-25
 Identities = 81/234 (34%), Positives = 118/234 (50%), Gaps = 23/234 (9%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKD-VVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           G +VN +D  G TPLH+AA +      +E LLRNDA   + D +G   +H +A  G    
Sbjct: 461 GASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLC 520

Query: 129 VRLLIHQGPSHTRVNEQNND---------NETALHCAAQYGHTEVVKVLLEELTDPTMRN 179
           ++L+  + P    +     D           + LH AA +GH + ++VL++ L D  +RN
Sbjct: 521 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 580

Query: 180 NKFETPLDLAALYGRLEVVKMLLNAHPNLLSCN-TKKHTPLHLAARNGHKAVVQVLLDAG 238
           +   TPLDLAA  G +E V +L+N   ++L  +   K TP+H AA NGH   +++L+   
Sbjct: 581 SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNA 640

Query: 239 --------MDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
                    D N QT     L  + L G TD V  LL  G +V+ KD  G TAL
Sbjct: 641 EPQNAVDIQDGNGQT----PLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTAL 690



 Score =  105 bits (261), Expect = 3e-22
 Identities = 79/261 (30%), Positives = 124/261 (47%), Gaps = 34/261 (13%)

Query: 57  SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP 116
           S H     L + RG N+N  D      +H AA  GH +VV++L+ + A     D K   P
Sbjct: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209

Query: 117 LHLAAWKGDAQIVRLLIHQG------------PSHTR------------------VNEQN 146
           LH AA  G   +V+ L+  G            P H                    VN++N
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269

Query: 147 NDNETALHCAAQYGHTEV-VKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAH 205
               T LH AA   H  + +++L+    D  M++   +TPL + AL+GR    + ++ + 
Sbjct: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 329

Query: 206 PNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGS-ALHEAALFGKTDVV 263
             ++ C  K  +TPLH+AAR GH+ ++  L+ +G D+  +   G   LH AAL G +D  
Sbjct: 330 A-VIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 388

Query: 264 QILLAAGTDVNIKDNHGLTAL 284
           + LL++G D++  D+ G T L
Sbjct: 389 RKLLSSGFDIDTPDDFGRTCL 409



 Score =  100 bits (249), Expect = 8e-21
 Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 4/202 (1%)

Query: 84  LHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
           L  A  NG  D V  L+      N  D++   PLH AA+ GDA+I+ LLI  G    RVN
Sbjct: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSG---ARVN 68

Query: 144 EQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLN 203
            +++   T LH A      E V+VLL+   D   R+  ++TPL +AA    ++  + L+ 
Sbjct: 69  AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP 128

Query: 204 AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSN-YQTEMGSALHEAALFGKTDV 262
              N+   +    T LH AA +GH  +V++LL  G + N +  +   A+H AA  G  +V
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV 188

Query: 263 VQILLAAGTDVNIKDNHGLTAL 284
           V++L++ G +V  KD    T L
Sbjct: 189 VKLLVSHGAEVTCKDKKSYTPL 210



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 82/288 (28%), Positives = 136/288 (47%), Gaps = 12/288 (4%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           +G NV+  D  G T LH  A+ GH++ V+ LL++ A   + DS+G  P+HL+A  G   +
Sbjct: 675 KGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGV 734

Query: 129 VRLLIHQGPSHTRVNEQNNDNE--TALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPL 186
           +  L+ Q  +    N    DN   TALH A   GH   V++LLE+        N F +PL
Sbjct: 735 LGALL-QSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPL 792

Query: 187 DLAALYGRLEVVKMLLNAHPNLL--SCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ 244
             A +       +ML++     +  + ++K  TPLH AA   H   +Q+LL      N  
Sbjct: 793 HCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV 852

Query: 245 TEMG-SALHEAALFGKTDVVQILL-AAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALI 302
              G + L  AA  G+T+ V++L+ +A  ++ ++DN   TAL     L   K  + +AL+
Sbjct: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL----HLACSKGHETSALL 908

Query: 303 EDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIID 350
                  R+           P  +++ + ++   Q  + K  + L +D
Sbjct: 909 ILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVD 956



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 77/236 (32%), Positives = 107/236 (45%), Gaps = 9/236 (3%)

Query: 52  GGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADS 111
           G +G     L S  SM   P     D+ GYT LH A  NGH+  VE+LL  +      + 
Sbjct: 730 GHIGVLGALLQSAASMDANPAT--ADNHGYTALHWACYNGHETCVELLLEQEVFQKT-EG 786

Query: 112 KGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE 171
               PLH A    +     +LI    +   VN  ++   T LH AA   H E +++LL  
Sbjct: 787 NAFSPLHCAVINDNEGAAEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSH 845

Query: 172 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLN-AHPNLLSCNTKKHTPLHLAARNGHKAV 230
                  ++  +TPL +AA  G+   V+ML++ A   L   +  K+T LHLA   GH+  
Sbjct: 846 NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETS 905

Query: 231 VQVLLDAGMDSNYQTEMGSAL----HEAALFGKTDVVQILLAAGTDVNIKDNHGLT 282
             ++L+   D N      +AL    H AA  G T VVQ LL  G  V   D +G T
Sbjct: 906 ALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 69/217 (31%), Positives = 106/217 (48%), Gaps = 5/217 (2%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDV-VEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           G  VN  +  G+TPLH AA + H  + +E+L+ N A  N+    G  PLH+ A  G    
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSR 321

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
            + +I  G     ++ ++ +  T LH AA+YGH  ++  L+    D   R      PL L
Sbjct: 322 SQTIIQSGAV---IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           AAL G  +  + LL++  ++ + +    T LH AA  G+   + +LL+ G D N + + G
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            S LH AA       +  L+ +G  VN  D  G T L
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 59/170 (34%), Positives = 85/170 (50%), Gaps = 5/170 (2%)

Query: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
           VN  DS G TPLH AA   H + +++LL ++A  N  DS G  PL +AA  G    V +L
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875

Query: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTM---RNNKFETPLDLA 189
           +    +   +  Q+N   TALH A   GH     ++LE++TD  +    N   +TPL +A
Sbjct: 876 VSSASAELTL--QDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVA 933

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGM 239
           A  G   VV+ LL    ++L+ +   +TP    A N   A    L+ A M
Sbjct: 934 ARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATM 983



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 66/197 (33%), Positives = 96/197 (48%), Gaps = 6/197 (3%)

Query: 77  DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADS-KGCYPLHLAAWKGDAQIVRLLIHQ 135
           +S+G TPL  AA  GH + V+VL+   A   V D      P+H AA  G ++ +RLLI  
Sbjct: 580 NSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN 639

Query: 136 GPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRL 195
                 V+ Q+ + +T L  +   GHT+ V  LL +  +   ++    T L   A+ G  
Sbjct: 640 AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHE 699

Query: 196 EVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMG---SA 250
           E V  LL      L  +++  TP+HL+A  GH  V+  LL   A MD+N  T      +A
Sbjct: 700 ECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA 759

Query: 251 LHEAALFGKTDVVQILL 267
           LH A   G    V++LL
Sbjct: 760 LHWACYNGHETCVELLL 776



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 65/223 (29%), Positives = 100/223 (44%), Gaps = 7/223 (3%)

Query: 65  LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
           L +  G +VN     G TPLH  AL+G     + ++++ A+ +  D  G  PLH+AA  G
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350

Query: 125 DAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFET 184
              ++  LI  G    +   +       LH AA  G ++  + LL    D    ++   T
Sbjct: 351 HELLINTLITSGADTAK---RGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRT 407

Query: 185 PLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ 244
            L  AA  G LE + +LLN   +    +    +PLH AA N +   +  L+ +G   N  
Sbjct: 408 CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467

Query: 245 TEMG-SALHEAALFGKTD--VVQILLAAGTDVNIKDNHGLTAL 284
            E G + LH AA    TD   ++ LL    +  I+D  G  A+
Sbjct: 468 DERGCTPLHYAAT-SDTDGKCLEYLLRNDANPGIRDKQGYNAV 509



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 1/75 (1%)

Query: 225 NGHKAVVQVLLDAGMDSNYQ-TEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTA 283
           NG    V+ L+    D N+Q  E  + LH AA  G  +++++L+ +G  VN KD+  LT 
Sbjct: 18  NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 77

Query: 284 LDTVRELPSQKSQQI 298
           L       S+++ Q+
Sbjct: 78  LHRAVASCSEEAVQV 92


>gi|110431370 espin [Homo sapiens]
          Length = 854

 Score =  117 bits (293), Expect = 6e-26
 Identities = 103/355 (29%), Positives = 156/355 (43%), Gaps = 17/355 (4%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALT-NVADSKGCYPLHLAAWKGDAQI 128
           G  V   D++G T LH AA  GH +VV  LL +       A   G  P+H AA KGD   
Sbjct: 94  GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPS 153

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEEL-TDPTMRNNKFETPLD 187
           +RLL+   P    VN Q  +  T L+ A Q GH EV + L++E   DP  R +   TPL 
Sbjct: 154 LRLLVEHYPEG--VNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLH 211

Query: 188 LAALYGRLEVVKMLLNAHPNLLSCNTKKH-TPLHLAARNGHKAVVQVLLDAGMDSNYQTE 246
            AA  G   V+  L++     LS   K   T +H AA  GH  V+  LL  G + +    
Sbjct: 212 AAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLW 271

Query: 247 MGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALD----TVRELPSQKSQQIAALI 302
            G+ LH+AA  G+ +  QIL+  G +++++D  G TA D          ++  + +  L 
Sbjct: 272 GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLS 331

Query: 303 EDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGPYE 362
            +H    R      +   P   + S   ++S +       + T  + ++D+ +      +
Sbjct: 332 VEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIK 391

Query: 363 ALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGV--RPRERPPPPAKPPP 415
                   H    ++S R++D  S           P G   +P   PPPP+ PPP
Sbjct: 392 GQ------HPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPP 440



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 74/222 (33%), Positives = 114/222 (51%), Gaps = 12/222 (5%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 128
           GP++   D     P+HHAA  G    +  L+   AL   A ++ G  P H A+  G    
Sbjct: 28  GPSLR--DPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLAC 85

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE-LTDPTMRNNKFETPLD 187
           ++ L+ QG    RV +++N   T LH AA++GH EVV  LL     DPT   +    P+ 
Sbjct: 86  LQWLLSQG--GCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIH 143

Query: 188 LAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLL-DAGMDSNYQT 245
            AA  G    +++L+  +P  ++  TK   TPL+LA + GH  V Q L+ + G D + + 
Sbjct: 144 YAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARA 203

Query: 246 EMG-SALHEAALFGKTDVVQILLAAGTDVNI--KDNHGLTAL 284
             G + LH AA  G + V+ + L + TDV++  +D  G TA+
Sbjct: 204 HDGMTPLHAAAQMGHSPVI-VWLVSCTDVSLSEQDKDGATAM 244



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 4/119 (3%)

Query: 156 AAQYGHTEVVKVL-LEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTK 214
           AA+ G  +V++ L    L  P++R+     P+  AA  G+L  ++ L+       +   +
Sbjct: 9   AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68

Query: 215 KH-TPLHLAARNGHKAVVQVLLDAG--MDSNYQTEMGSALHEAALFGKTDVVQILLAAG 270
              TP H A+  GH A +Q LL  G     +      + LH AA FG  +VV  LL  G
Sbjct: 69  NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score =  114 bits (285), Expect = 5e-25
 Identities = 84/239 (35%), Positives = 125/239 (52%), Gaps = 14/239 (5%)

Query: 50  GGGGLGS------SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRND 103
           G GGL +      + H  ++ + +  G NVN  D+  +TPLH AA  GH+ V  +LL+  
Sbjct: 131 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFG 190

Query: 104 ALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTE 163
           A  NV+   G  PLHLA+ KG   I +LL+ +G S   VN Q+N++   LH  +++GH +
Sbjct: 191 ADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG-SKADVNAQDNEDHVPLHFCSRFGHHD 249

Query: 164 VVKVLLEE--LTDPTMRNNKFETPLDLAALYGRLEVVKML--LNAHPNLLSCNTKKHTPL 219
           +VK LL+      P + N   +TPL LA   G+ EV K +  ++   +L   N    T  
Sbjct: 250 IVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAF 309

Query: 220 HLAARNGHKA-VVQVLLDAG-MDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNI 275
           H A   G    +V+ LLD   ++ N+Q   G + LH A   G   +VQ LL  G D+N+
Sbjct: 310 HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 72/226 (31%), Positives = 115/226 (50%), Gaps = 16/226 (7%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++  V   G T LH A + GH +  +VLL++ A  N+ D+    PLH+AA+ G  Q+ 
Sbjct: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE--LTDPTMRNNKFETPLD 187
           RLL+  G     VN      +  LH A+  G   + K+L+EE    D   ++N+   PL 
Sbjct: 184 RLLLKFGAD---VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240

Query: 188 LAALYGRLEVVKMLLNA----HPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD-AGMDSN 242
             + +G  ++VK LL +     P+++  N    TPLHLA  NG   V + ++  +G +S 
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVV--NIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298

Query: 243 YQTEMGS--ALHEAALFGKT-DVVQILLAAGT-DVNIKDNHGLTAL 284
            +  + S  A H A  +GK+ D+V+ LL     ++N +   G T L
Sbjct: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGL 344



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 64/230 (27%), Positives = 109/230 (47%), Gaps = 12/230 (5%)

Query: 55  GSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGC 114
           G  SH  + +L   +G   + +   G+T LH A    + +++  LL + A        G 
Sbjct: 79  GKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGL 135

Query: 115 YPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTD 174
             LH+A   G  +   +L+  G     VN Q+    T LH AA YGH +V ++LL+   D
Sbjct: 136 TALHIATIAGHLEAADVLLQHG---ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 175 PTMRNNKFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQ 232
             +     + PL LA+  G L + K+L+   +  ++ + + + H PLH  +R GH  +V+
Sbjct: 193 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK 252

Query: 233 VLLDAGMDSN---YQTEMGSALHEAALFGKTDVV-QILLAAGTDVNIKDN 278
            LL + ++           + LH A   GK +V  +I+  +GT+   K+N
Sbjct: 253 YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 302



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 42/148 (28%), Positives = 65/148 (43%), Gaps = 8/148 (5%)

Query: 138 SHTRVNEQNNDNETALH----CAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYG 193
           S   +N +  +  + LH    C  +  H   +  +L+ L    +  N F T L LA    
Sbjct: 56  SKVNLNYRTENGLSLLHLCCICGGKKSHIRTL--MLKGLRPSRLTRNGF-TALHLAVYKD 112

Query: 194 RLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEM-GSALH 252
             E++  LL++  ++        T LH+A   GH     VLL  G + N Q  +  + LH
Sbjct: 113 NAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 172

Query: 253 EAALFGKTDVVQILLAAGTDVNIKDNHG 280
            AA +G   V ++LL  G DVN+    G
Sbjct: 173 IAAYYGHEQVTRLLLKFGADVNVSGEVG 200


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score =  114 bits (285), Expect = 5e-25
 Identities = 84/239 (35%), Positives = 125/239 (52%), Gaps = 14/239 (5%)

Query: 50  GGGGLGS------SSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRND 103
           G GGL +      + H  ++ + +  G NVN  D+  +TPLH AA  GH+ V  +LL+  
Sbjct: 232 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFG 291

Query: 104 ALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTE 163
           A  NV+   G  PLHLA+ KG   I +LL+ +G S   VN Q+N++   LH  +++GH +
Sbjct: 292 ADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG-SKADVNAQDNEDHVPLHFCSRFGHHD 350

Query: 164 VVKVLLEE--LTDPTMRNNKFETPLDLAALYGRLEVVKML--LNAHPNLLSCNTKKHTPL 219
           +VK LL+      P + N   +TPL LA   G+ EV K +  ++   +L   N    T  
Sbjct: 351 IVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAF 410

Query: 220 HLAARNGHKA-VVQVLLDAG-MDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNI 275
           H A   G    +V+ LLD   ++ N+Q   G + LH A   G   +VQ LL  G D+N+
Sbjct: 411 HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 72/226 (31%), Positives = 115/226 (50%), Gaps = 16/226 (7%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G ++  V   G T LH A + GH +  +VLL++ A  N+ D+    PLH+AA+ G  Q+ 
Sbjct: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE--LTDPTMRNNKFETPLD 187
           RLL+  G     VN      +  LH A+  G   + K+L+EE    D   ++N+   PL 
Sbjct: 285 RLLLKFGAD---VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 341

Query: 188 LAALYGRLEVVKMLLNA----HPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD-AGMDSN 242
             + +G  ++VK LL +     P+++  N    TPLHLA  NG   V + ++  +G +S 
Sbjct: 342 FCSRFGHHDIVKYLLQSDLEVQPHVV--NIYGDTPLHLACYNGKFEVAKEIIQISGTESL 399

Query: 243 YQTEMGS--ALHEAALFGKT-DVVQILLAAGT-DVNIKDNHGLTAL 284
            +  + S  A H A  +GK+ D+V+ LL     ++N +   G T L
Sbjct: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGL 445



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 64/230 (27%), Positives = 109/230 (47%), Gaps = 12/230 (5%)

Query: 55  GSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGC 114
           G  SH  + +L   +G   + +   G+T LH A    + +++  LL + A        G 
Sbjct: 180 GKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGL 236

Query: 115 YPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTD 174
             LH+A   G  +   +L+  G     VN Q+    T LH AA YGH +V ++LL+   D
Sbjct: 237 TALHIATIAGHLEAADVLLQHG---ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 293

Query: 175 PTMRNNKFETPLDLAALYGRLEVVKMLL--NAHPNLLSCNTKKHTPLHLAARNGHKAVVQ 232
             +     + PL LA+  G L + K+L+   +  ++ + + + H PLH  +R GH  +V+
Sbjct: 294 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK 353

Query: 233 VLLDAGMDSN---YQTEMGSALHEAALFGKTDVV-QILLAAGTDVNIKDN 278
            LL + ++           + LH A   GK +V  +I+  +GT+   K+N
Sbjct: 354 YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 403



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 42/148 (28%), Positives = 65/148 (43%), Gaps = 8/148 (5%)

Query: 138 SHTRVNEQNNDNETALH----CAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYG 193
           S   +N +  +  + LH    C  +  H   +  +L+ L    +  N F T L LA    
Sbjct: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTL--MLKGLRPSRLTRNGF-TALHLAVYKD 213

Query: 194 RLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEM-GSALH 252
             E++  LL++  ++        T LH+A   GH     VLL  G + N Q  +  + LH
Sbjct: 214 NAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 273

Query: 253 EAALFGKTDVVQILLAAGTDVNIKDNHG 280
            AA +G   V ++LL  G DVN+    G
Sbjct: 274 IAAYYGHEQVTRLLLKFGADVNVSGEVG 301


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  112 bits (281), Expect = 2e-24
 Identities = 73/214 (34%), Positives = 107/214 (50%), Gaps = 4/214 (1%)

Query: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
           +V+C  ++GYTPL  AA +   D+  +LL + A  N  D  G  PLH AA  GD    RL
Sbjct: 387 DVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARL 446

Query: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAAL 191
           L+  G     V+ Q  +  T LH AAQ     V ++L+    DP +   + +TPL +AA 
Sbjct: 447 LLDHGAC---VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503

Query: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SA 250
           +G + +VK+L +    L +      TPLHLA   G    +Q LL +G   +   + G   
Sbjct: 504 FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563

Query: 251 LHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           LH AA  GK  + ++LL  G  + +  + G T L
Sbjct: 564 LHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597



 Score =  105 bits (261), Expect = 3e-22
 Identities = 78/250 (31%), Positives = 122/250 (48%), Gaps = 12/250 (4%)

Query: 75  CVDST---GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
           CVD+    G+TPLH AA N  ++V  +L+   A  N+ +++G  PLH+AA+ G   +V+L
Sbjct: 453 CVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKL 512

Query: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAAL 191
           L  QG     ++ Q  +  T LH A + G    ++ LL+    P   +     PL  AA 
Sbjct: 513 LTSQG---AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569

Query: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SA 250
            G+  + KMLL    +L     +  TPLHLAA  GH  ++ +L ++  +      +  + 
Sbjct: 570 RGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP 629

Query: 251 LHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAAL-IEDHMTGK 309
           LH AA  G+  VV  LL  G D N  +  G T L     L  Q+S  ++ + + +H    
Sbjct: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL----HLAVQRSTFLSVINLLEHHANV 685

Query: 310 RSTKEVDKTP 319
            +  +V  TP
Sbjct: 686 HARNKVGWTP 695



 Score =  100 bits (249), Expect = 8e-21
 Identities = 64/171 (37%), Positives = 88/171 (51%), Gaps = 3/171 (1%)

Query: 74  NCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLI 133
           + +D +GY PLH AA  G   + ++LLR  A   +   +G  PLHLAA+KG  +I+ LL 
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613

Query: 134 HQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYG 193
               SH  +      N T LH AA++G   VV  LL+   DP        TPL LA    
Sbjct: 614 E---SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670

Query: 194 RLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ 244
               V  LL  H N+ + N    TP HLAA  G+ A+++VL++AG   + Q
Sbjct: 671 TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 45/145 (31%), Positives = 71/145 (48%), Gaps = 5/145 (3%)

Query: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGD-AQIVR 130
           N+  + +  +TPLH AA +G + VV  LL+  A  N A+  G  PLHLA  +     ++ 
Sbjct: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677

Query: 131 LLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAA 190
           LL H    H  V+ +N    T  H AA  G+T ++KVL+E      +++    TPL LA 
Sbjct: 678 LLEH----HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733

Query: 191 LYGRLEVVKMLLNAHPNLLSCNTKK 215
              +  ++  L    P++ +    K
Sbjct: 734 RSRKQGIMSFLEGKEPSVATLGGSK 758



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 23/67 (34%), Positives = 35/67 (52%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G + N  + +G+TPLH A        V  LL + A  +  +  G  P HLAA KG+  I+
Sbjct: 649 GADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708

Query: 130 RLLIHQG 136
           ++L+  G
Sbjct: 709 KVLVEAG 715


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  112 bits (281), Expect = 2e-24
 Identities = 79/217 (36%), Positives = 115/217 (52%), Gaps = 6/217 (2%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  VN  D+   TPLH A  +  ++ V+VL+++ A  N  D     PLH+AA     +  
Sbjct: 39  GARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCA 98

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
            ++I   P  + VN  +    TALH AA  GH E+V +LL +  +    + K    L  A
Sbjct: 99  EVII---PLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWA 155

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           A  G L+VV +L+N H   ++C  KK +TPLH AA NG   VV+ LL+ G++ +     G
Sbjct: 156 AYMGHLDVVALLIN-HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            +ALH A   G+  VV  L+  G +VN  +N+G T L
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPL 251



 Score =  109 bits (273), Expect = 1e-23
 Identities = 77/215 (35%), Positives = 111/215 (51%), Gaps = 5/215 (2%)

Query: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
           +VN  D    TPLH AA N      EV++   +  NV+D  G   LH AA  G  ++V L
Sbjct: 74  DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNL 133

Query: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAAL 191
           L+ +G +   +N  +  +  ALH AA  GH +VV +L+    + T ++ K  TPL  AA 
Sbjct: 134 LLAKGAN---INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAAS 190

Query: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SA 250
            G++ VVK LLN    +   N   +T LH+A  NG  AVV  L+D G + N     G + 
Sbjct: 191 NGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTP 250

Query: 251 LHEAALFGKTDV-VQILLAAGTDVNIKDNHGLTAL 284
           LH AA      + +++L+  G DVNI+   G + L
Sbjct: 251 LHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 79/249 (31%), Positives = 118/249 (47%), Gaps = 36/249 (14%)

Query: 70  GPNVNCVDSTGYTPLHHAAL-----------NGHKD-----------------VVEVLLR 101
           G NVN  D  G T LH+AA            N H +                  +E LL+
Sbjct: 436 GANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ 495

Query: 102 NDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGH 161
           NDA  ++ D +G   +H AA  G  Q + LL+ +  S    ++ +   ++ LH AA  GH
Sbjct: 496 NDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESD-SGATKSPLHLAAYNGH 554

Query: 162 TEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNL-LSCNTKKHTPLH 220
            + ++VLL+ L D  +R+ K  T LDLAA  G  E V+ L+N   ++ +  N  K TPLH
Sbjct: 555 HQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLH 614

Query: 221 LAARNGHKAVVQVLLDAGMDSNYQTEMGSA-----LHEAALFGKTDVVQILLAAGTDVNI 275
            +  NGH   +++LL+   D+    ++  A     L  A  +G  D V +LL    +V+ 
Sbjct: 615 ASVINGHTLCLRLLLEIA-DNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT 673

Query: 276 KDNHGLTAL 284
            D  G TAL
Sbjct: 674 VDILGCTAL 682



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 73/211 (34%), Positives = 110/211 (52%), Gaps = 11/211 (5%)

Query: 82  TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
           +PLH AA NGH   +EVLL++    ++ D KG   L LAA+KG  + V  LI+ G S   
Sbjct: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS--I 601

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDP---TMRNNKFETPLDLAALYGRLEVV 198
             + N    T LH +   GHT  +++LLE   +P    +++ K +TPL LA  YG ++ V
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661

Query: 199 KMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALF 257
            +LL    N+ + +    T LH     GH+  VQ+LL+  +    +   G + LH AA  
Sbjct: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721

Query: 258 GK----TDVVQILLAAGTDVNIKDNHGLTAL 284
           G     ++++Q+ L+   D   KDN G T L
Sbjct: 722 GHATWLSELLQMALSE-EDCCFKDNQGYTPL 751



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 70/191 (36%), Positives = 100/191 (52%), Gaps = 10/191 (5%)

Query: 98  VLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAA 157
           +L+      N  DS+   PLH+AA+ GDA+I+ LLI  G    RVN ++N   T LH A 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSG---ARVNAKDNMWLTPLHRAV 57

Query: 158 QYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH- 216
                E V+VL++   D   R+  ++TPL +AA    ++  ++++   P L S N     
Sbjct: 58  ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVII---PLLSSVNVSDRG 114

Query: 217 --TPLHLAARNGHKAVVQVLLDAGMDSN-YQTEMGSALHEAALFGKTDVVQILLAAGTDV 273
             T LH AA NGH  +V +LL  G + N +  +   ALH AA  G  DVV +L+  G +V
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174

Query: 274 NIKDNHGLTAL 284
             KD  G T L
Sbjct: 175 TCKDKKGYTPL 185



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 71/252 (28%), Positives = 114/252 (45%), Gaps = 32/252 (12%)

Query: 65  LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
           L + +G N+N  D      LH AA  GH DVV +L+ + A     D KG  PLH AA  G
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192

Query: 125 DAQIVRLLIHQGPS------------------------------HTRVNEQNNDNETALH 154
              +V+ L++ G                                   VN+ NN+  T LH
Sbjct: 193 QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLH 252

Query: 155 CAAQYGHTEV-VKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNT 213
            AA   H  + +++L+    D  +++   ++PL + A++GR    + L+     +   + 
Sbjct: 253 FAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 312

Query: 214 KKHTPLHLAARNGHKAVVQVLLDAGMD-SNYQTEMGSALHEAALFGKTDVVQILLAAGTD 272
             +TPLH+AAR GH+ ++  L  +G D +         LH AAL   +D  + LL++G +
Sbjct: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372

Query: 273 VNIKDNHGLTAL 284
           ++  D  G T L
Sbjct: 373 IDTPDKFGRTCL 384



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 72/247 (29%), Positives = 106/247 (42%), Gaps = 32/247 (12%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  V C D  GYTPLH AA NG  +VV+ LL      +  +  G   LH+A + G   +V
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230

Query: 130 RLLIHQG------------PSH-------------------TRVNEQNNDNETALHCAAQ 158
             LI  G            P H                     VN Q+ D ++ LH  A 
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290

Query: 159 YGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTP 218
           +G     + L++   +    +    TPL +AA YG   ++  L  +  +   C      P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350

Query: 219 LHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKD 277
           LHLAA N H    + LL +G + +   + G + LH AA  G  + +++L ++G D + KD
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410

Query: 278 NHGLTAL 284
             G T L
Sbjct: 411 KCGRTPL 417



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 75/254 (29%), Positives = 118/254 (46%), Gaps = 8/254 (3%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDV-VEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           G NVN  ++ G+TPLH AA + H  + +E+L+ N A  N+    G  PLH+ A  G    
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
            + LI  G     V++  N   T LH AA+YGH  ++  L     D          PL L
Sbjct: 297 SQTLIQNGGEIDCVDKDGN---TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL 353

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           AAL    +  + LL++   + + +    T LH AA  G+   +++L  +G D + + + G
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDH-- 305
            + LH AA       ++ L+  G +VN  D+ G TAL         +++ I     D+  
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473

Query: 306 -MTGKRSTKEVDKT 318
            +   R  KE + T
Sbjct: 474 ELERARELKEKEAT 487



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 76/235 (32%), Positives = 110/235 (46%), Gaps = 9/235 (3%)

Query: 72  NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
           NV+ VD  G T LH   + GH++ V++LL  +      DS+G  PLH AA +G A  +  
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729

Query: 132 LIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAAL 191
           L+    S      ++N   T LH A   G+   ++VLLE+        N F TPL  A +
Sbjct: 730 LLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-TPLHCAII 788

Query: 192 YGRLEVVKMLLNA-HPNLLSC-NTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG- 248
                   +LL A   +++SC + K  TPL  AA   H   +Q+LL      N     G 
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848

Query: 249 SALHEAALFGKTDVVQILL-AAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALI 302
           +AL  AA  G+   V IL+ +A  D+ +KD      L+T   L   K  +  AL+
Sbjct: 849 TALMMAAENGQAGAVDILVNSAQADLTVKDKD----LNTPLHLACSKGHEKCALL 899



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 70/228 (30%), Positives = 106/228 (46%), Gaps = 30/228 (13%)

Query: 70  GPNVNCV-------------DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP 116
           G NV C+             D  G TPLH+AA N H   +E L+   A  N  D  G   
Sbjct: 390 GGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTA 449

Query: 117 LHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEV---VKVLLEELT 173
           LH AA     +   +L   G +H        DN   L  A +    E    ++ LL+   
Sbjct: 450 LHYAAASDMDRNKTIL---GNAH--------DNSEELERARELKEKEATLCLEFLLQNDA 498

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLL--SCNTKKHTPLHLAARNGHKAVV 231
           +P++R+ +    +  AA YG  + +++LL    +    S +    +PLHLAA NGH   +
Sbjct: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQAL 558

Query: 232 QVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
           +VLL + +D + + E G +AL  AA  G T+ V+ L+  G  + +KDN
Sbjct: 559 EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDN 606



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 70/223 (31%), Positives = 102/223 (45%), Gaps = 20/223 (8%)

Query: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
           V+  D+ G TPL  A   GH D V +LL  +A  +  D  GC  LH     G  + V++L
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697

Query: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGH----TEVVKVLLEELTDPTMRNNKFETPLDL 188
           + Q  S   +  +++   T LH AA  GH    +E++++ L E  D   ++N+  TPL  
Sbjct: 698 LEQEVS---ILCKDSRGRTPLHYAAARGHATWLSELLQMALSE-EDCCFKDNQGYTPLHW 753

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTK----KHTPLHLAARNGHKAVVQVLL---DAGMDS 241
           A   G    +++LL        C  K      TPLH A  N H     +LL   D+ + S
Sbjct: 754 ACYNGNENCIEVLLEQ-----KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808

Query: 242 NYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
               +  + L  AA     + +Q+LL     VN  DN G TAL
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 61/193 (31%), Positives = 89/193 (46%), Gaps = 4/193 (2%)

Query: 61  LSSLLSMWRGPNVNCV-DSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHL 119
           LS LL M       C  D+ GYTPLH A  NG+++ +EVLL          +    PLH 
Sbjct: 727 LSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT-PLHC 785

Query: 120 AAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRN 179
           A          LL+    S   V+ +++   T L  AA   H E +++LL         +
Sbjct: 786 AIINDHGNCASLLLGAIDSSI-VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVD 844

Query: 180 NKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAG 238
           N  +T L +AA  G+   V +L+N+    L+   K  +TPLHLA   GH+    ++LD  
Sbjct: 845 NSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKI 904

Query: 239 MDSNYQTEMGSAL 251
            D +   E  +AL
Sbjct: 905 QDESLINEKNNAL 917



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 13/220 (5%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  ++  D  G T LH AA  G+ + +++L  + A  +  D  G  PLH AA       +
Sbjct: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCI 429

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             L+  G +   VNE ++   TALH AA     +  K +L    D    + + E   +L 
Sbjct: 430 ETLVTTGAN---VNETDDWGRTALHYAAA-SDMDRNKTILGNAHD---NSEELERARELK 482

Query: 190 ALYGRLEVVKMLLN-AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD---AGMDSNYQT 245
                L +  +L N A+P++   + + +  +H AA  GH+  +++LL+   +G + +   
Sbjct: 483 EKEATLCLEFLLQNDANPSIR--DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540

Query: 246 EMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALD 285
              S LH AA  G    +++LL +  D++I+D  G TALD
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALD 580



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 29/80 (36%), Positives = 43/80 (53%), Gaps = 1/80 (1%)

Query: 73  VNCVDSTGYTPLHHAALNGHKDVVEVLLRN-DALTNVADSKGCYPLHLAAWKGDAQIVRL 131
           VN VD++G T L  AA NG    V++L+ +  A   V D     PLHLA  KG  +   L
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALL 899

Query: 132 LIHQGPSHTRVNEQNNDNET 151
           ++ +    + +NE+NN  +T
Sbjct: 900 ILDKIQDESLINEKNNALQT 919



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 20/59 (33%), Positives = 34/59 (57%), Gaps = 2/59 (3%)

Query: 245 TEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIE 303
           +E  + LH AA  G  +++++L+ +G  VN KDN  LT L   R + S+  + +  LI+
Sbjct: 14  SEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLH--RAVASRSEEAVQVLIK 70


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score =  112 bits (281), Expect = 2e-24
 Identities = 90/267 (33%), Positives = 130/267 (48%), Gaps = 18/267 (6%)

Query: 62   SSLLSMWRGPNVNC-VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
            S++L ++   +++   +S   T L  A   GH+++V+ LL   A     D KG  PL LA
Sbjct: 1064 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 1123

Query: 121  AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
            A  G   +V +L+  G      +E+  D   +L C+   G  EVV++LL    +   RN 
Sbjct: 1124 ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSG--GRQEVVELLLARGANKEHRNV 1181

Query: 181  KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK--HTPLHLAARNGHKAVVQVLLDAG 238
               TPL LAA  G + ++K+LLNA   + S    K   +PL LAA NGH A V++LLD G
Sbjct: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241

Query: 239  MDSNYQ--TEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQ 296
             D N Q  T   +AL  A   G+T+VV +LL    +V  +   GLT L    E  S    
Sbjct: 1242 SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL---MEAASGGYA 1298

Query: 297  QIAALIEDHMTGKRSTKEVDKTPPPQP 323
            ++  ++ D        K  D   PP P
Sbjct: 1299 EVGRVLLD--------KGADVNAPPVP 1317



 Score =  105 bits (261), Expect = 3e-22
 Identities = 71/209 (33%), Positives = 107/209 (51%), Gaps = 6/209 (2%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP-LHLAAWKGDAQI 128
           G ++   +  G+TPL  A   GH +V  +LL N A  N   ++     L LA +KG  ++
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VR L+  G        + ++  TAL  A   GH EV ++LL+      M  + FE+PL L
Sbjct: 417 VRFLLEAGADQ---EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE-- 246
           AA  G +E+  +L+    +L   N + +TPL  AAR GH+ +V +LL  G + N QTE  
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533

Query: 247 MGSALHEAALFGKTDVVQILLAAGTDVNI 275
             +AL  A   G  +V   L+ AG D+ +
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIEL 562



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 78/225 (34%), Positives = 110/225 (48%), Gaps = 7/225 (3%)

Query: 65   LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTN--VADSKGCYPLHLAAW 122
            L + RG N    + + YTPL  AA  G+ +++++LL   A  N       G  PL LAA 
Sbjct: 1168 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1227

Query: 123  KGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
             G    V+LL+  G       E N +  TAL  A   G TEVV +LL+   +   R    
Sbjct: 1228 NGHTAAVKLLLDMGSDINAQIETNRN--TALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285

Query: 183  ETPLDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240
             TPL  AA  G  EV ++LL+  A  N     + + T L +AA  GH    ++L+  G  
Sbjct: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345

Query: 241  SNYQTEMGSA-LHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             + + + G+  L  AA  G  DVVQ+L+ AG DV+  DN  +T L
Sbjct: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 74/240 (30%), Positives = 112/240 (46%), Gaps = 9/240 (3%)

Query: 82  TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
           TPL  AA  GH  +V++LL + A  N   S G   L  A   G   +V++L+  G S   
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS--- 359

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF-ETPLDLAALYGRLEVVKM 200
           + + N +  T L  A   GH EV ++LLE        +N+F E+ L LA   G LE+V+ 
Sbjct: 360 IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRF 419

Query: 201 LLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE-MGSALHEAALFGK 259
           LL A  +      + HT L  A  +GH  V ++LLD+G   N   +   S L  AA  G 
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 479

Query: 260 TDVVQILLAAGTDVNIKDNHGLTAL-DTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKT 318
            ++  +L+  G  +   ++ G T L +  RE      + +A L+         T+E  +T
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAARE---GHEEMVALLLGQGANINAQTEETQET 536



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 73/207 (35%), Positives = 103/207 (49%), Gaps = 8/207 (3%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  VN    +  +PL  AA  GH ++  +L+   A     + +G  PL  AA +G  ++V
Sbjct: 457 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516

Query: 130 RLLIHQGPSHTRVNEQNNDN-ETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
            LL+ QG +   +N Q  +  ETAL  A   G  EV   L++   D  +  +   TPL  
Sbjct: 517 ALLLGQGAN---INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           AA  G LE+VK LL A  N+ +      T L  A  NGH  V  VLL AG D  +++E G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVN 274
            + L +AA  G    VQ L++ G +VN
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVN 657



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 74/229 (32%), Positives = 100/229 (43%), Gaps = 9/229 (3%)

Query: 59  HPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNV-ADSKGCYPL 117
           H   + L + RG ++  V+  GYTPL  AA  GH+++V +LL   A  N   +      L
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538

Query: 118 HLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTM 177
            LA   G  ++   LI  G       +      T L  AAQ GH E+VK LL    +   
Sbjct: 539 TLACCGGFLEVADFLIKAGA------DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592

Query: 178 RNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDA 237
                +T L  A   G  +V  +LL A  +L   +    TPL  AAR GH   VQ L+  
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652

Query: 238 GMDSNYQTEMG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           G + N  T     + L  A   G   VV++LLA G D   +   G T L
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 57/180 (31%), Positives = 91/180 (50%), Gaps = 2/180 (1%)

Query: 57   SSHPLSSLLSMWRGPNVNC-VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY 115
            + H  +  L +  G ++N  +++   T L  A   G  +VV +LL   A        G  
Sbjct: 1228 NGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLT 1287

Query: 116  PLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDP 175
            PL  AA  G A++ R+L+ +G +        +  +TAL  AA  GH +  ++L+      
Sbjct: 1288 PLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346

Query: 176  TMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLL 235
             +RN K  TPL LAA  G L+VV++L+ A  ++ + + +K TPL  A R GH  VV+ L+
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 63/204 (30%), Positives = 96/204 (47%), Gaps = 6/204 (2%)

Query: 84  LHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
           L  A   G  + V  LL      N    +G   L LA   G  ++ ++L+     H  V 
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM---HANVE 294

Query: 144 EQNNDNE-TALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLL 202
           ++    + T L  AA  GH ++VK+LL    D   +++   T L  A   G ++VVK+LL
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354

Query: 203 NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKT 260
            +  ++   N   HTPL  A   GH  V ++LL+  AG++++      SAL  A   G  
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 261 DVVQILLAAGTDVNIKDNHGLTAL 284
           ++V+ LL AG D   K +   TAL
Sbjct: 415 EMVRFLLEAGADQEHKTDEMHTAL 438



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 55/141 (39%), Positives = 68/141 (48%), Gaps = 2/141 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NV+   +TG T L +A  NGH DV +VLL+  A        G  PL  AA  G    V
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + LI +G +  R    N+    +L CA   GH  VV++LL    DPT R     T L  A
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAG--GHLAVVELLLAHGADPTHRLKDGSTMLIEA 704

Query: 190 ALYGRLEVVKMLLNAHPNLLS 210
           A  G   VV  LL+   NLLS
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLS 725



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 88/317 (27%), Positives = 130/317 (41%), Gaps = 45/317 (14%)

Query: 29  SSGFGGGGGGGSGGGGGGSGGGGGGLGSSSH-------------PLSSLLSMWRGPNVNC 75
           SS         SGGGGGG GGGGGG G+SS+              +S + S     + + 
Sbjct: 84  SSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFIL--DQDD 141

Query: 76  VDSTGYTPLHHAALNGHKDVV-------EVLLRNDALTNVADSKGCYPLHLAAWK--GDA 126
           +++          L+G  D         E   R +AL   A   G   L  A  K   D 
Sbjct: 142 LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA---GIGKLSTADGKAFADP 198

Query: 127 QIVRLLI--------HQGPSHTRVNEQNNDN-----ETALHCAAQYGHTEVVKVLLEELT 173
           +++R L             + TR+  ++  N       +L  A   G    V+ LL E  
Sbjct: 199 EVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGR 258

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH-TPLHLAARNGHKAVVQ 232
                  + E+ L LA   G  E+ ++LL  H N+     K   TPL  AA  GH  +V+
Sbjct: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVK 318

Query: 233 VLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELP 291
           +LL    D N Q+  G +AL  A   G  DVV++LL +G  +   + +G T L    E  
Sbjct: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPL---MEAG 375

Query: 292 SQKSQQIAALIEDHMTG 308
           S    ++A L+ ++  G
Sbjct: 376 SAGHVEVARLLLENGAG 392



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 6/92 (6%)

Query: 65   LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
            L + RG +++  +  G TPL  AA  GH DVV++L++  A  + AD++   PL  A  KG
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397

Query: 125  DAQIVRLLIHQGPSHTRVNEQNNDNETALHCA 156
              ++VR L+ +      VN+  +D+E   + A
Sbjct: 1398 HVKVVRYLVKE------VNQFPSDSECMRYIA 1423


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  112 bits (281), Expect = 2e-24
 Identities = 90/267 (33%), Positives = 130/267 (48%), Gaps = 18/267 (6%)

Query: 62   SSLLSMWRGPNVNC-VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
            S++L ++   +++   +S   T L  A   GH+++V+ LL   A     D KG  PL LA
Sbjct: 813  SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILA 872

Query: 121  AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
            A  G   +V +L+  G      +E+  D   +L C+   G  EVV++LL    +   RN 
Sbjct: 873  ATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSG--GRQEVVELLLARGANKEHRNV 930

Query: 181  KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK--HTPLHLAARNGHKAVVQVLLDAG 238
               TPL LAA  G + ++K+LLNA   + S    K   +PL LAA NGH A V++LLD G
Sbjct: 931  SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990

Query: 239  MDSNYQ--TEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQ 296
             D N Q  T   +AL  A   G+T+VV +LL    +V  +   GLT L    E  S    
Sbjct: 991  SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL---MEAASGGYA 1047

Query: 297  QIAALIEDHMTGKRSTKEVDKTPPPQP 323
            ++  ++ D        K  D   PP P
Sbjct: 1048 EVGRVLLD--------KGADVNAPPVP 1066



 Score =  105 bits (261), Expect = 3e-22
 Identities = 71/209 (33%), Positives = 107/209 (51%), Gaps = 6/209 (2%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP-LHLAAWKGDAQI 128
           G ++   +  G+TPL  A   GH +V  +LL N A  N   ++     L LA +KG  ++
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VR L+  G        + ++  TAL  A   GH EV ++LL+      M  + FE+PL L
Sbjct: 417 VRFLLEAGADQ---EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE-- 246
           AA  G +E+  +L+    +L   N + +TPL  AAR GH+ +V +LL  G + N QTE  
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533

Query: 247 MGSALHEAALFGKTDVVQILLAAGTDVNI 275
             +AL  A   G  +V   L+ AG D+ +
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIEL 562



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 78/225 (34%), Positives = 110/225 (48%), Gaps = 7/225 (3%)

Query: 65   LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTN--VADSKGCYPLHLAAW 122
            L + RG N    + + YTPL  AA  G+ +++++LL   A  N       G  PL LAA 
Sbjct: 917  LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 976

Query: 123  KGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
             G    V+LL+  G       E N +  TAL  A   G TEVV +LL+   +   R    
Sbjct: 977  NGHTAAVKLLLDMGSDINAQIETNRN--TALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1034

Query: 183  ETPLDLAALYGRLEVVKMLLN--AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD 240
             TPL  AA  G  EV ++LL+  A  N     + + T L +AA  GH    ++L+  G  
Sbjct: 1035 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1094

Query: 241  SNYQTEMGSA-LHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             + + + G+  L  AA  G  DVVQ+L+ AG DV+  DN  +T L
Sbjct: 1095 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1139



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 74/240 (30%), Positives = 112/240 (46%), Gaps = 9/240 (3%)

Query: 82  TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
           TPL  AA  GH  +V++LL + A  N   S G   L  A   G   +V++L+  G S   
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS--- 359

Query: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF-ETPLDLAALYGRLEVVKM 200
           + + N +  T L  A   GH EV ++LLE        +N+F E+ L LA   G LE+V+ 
Sbjct: 360 IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRF 419

Query: 201 LLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE-MGSALHEAALFGK 259
           LL A  +      + HT L  A  +GH  V ++LLD+G   N   +   S L  AA  G 
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 479

Query: 260 TDVVQILLAAGTDVNIKDNHGLTAL-DTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKT 318
            ++  +L+  G  +   ++ G T L +  RE      + +A L+         T+E  +T
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAARE---GHEEMVALLLGQGANINAQTEETQET 536



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 73/207 (35%), Positives = 103/207 (49%), Gaps = 8/207 (3%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  VN    +  +PL  AA  GH ++  +L+   A     + +G  PL  AA +G  ++V
Sbjct: 457 GAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516

Query: 130 RLLIHQGPSHTRVNEQNNDN-ETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
            LL+ QG +   +N Q  +  ETAL  A   G  EV   L++   D  +  +   TPL  
Sbjct: 517 ALLLGQGAN---INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           AA  G LE+VK LL A  N+ +      T L  A  NGH  V  VLL AG D  +++E G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVN 274
            + L +AA  G    VQ L++ G +VN
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVN 657



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 74/229 (32%), Positives = 100/229 (43%), Gaps = 9/229 (3%)

Query: 59  HPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNV-ADSKGCYPL 117
           H   + L + RG ++  V+  GYTPL  AA  GH+++V +LL   A  N   +      L
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538

Query: 118 HLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTM 177
            LA   G  ++   LI  G       +      T L  AAQ GH E+VK LL    +   
Sbjct: 539 TLACCGGFLEVADFLIKAGA------DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHA 592

Query: 178 RNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDA 237
                +T L  A   G  +V  +LL A  +L   +    TPL  AAR GH   VQ L+  
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652

Query: 238 GMDSNYQTEMG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           G + N  T     + L  A   G   VV++LLA G D   +   G T L
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 57/180 (31%), Positives = 91/180 (50%), Gaps = 2/180 (1%)

Query: 57   SSHPLSSLLSMWRGPNVNC-VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY 115
            + H  +  L +  G ++N  +++   T L  A   G  +VV +LL   A        G  
Sbjct: 977  NGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLT 1036

Query: 116  PLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDP 175
            PL  AA  G A++ R+L+ +G +        +  +TAL  AA  GH +  ++L+      
Sbjct: 1037 PLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1095

Query: 176  TMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLL 235
             +RN K  TPL LAA  G L+VV++L+ A  ++ + + +K TPL  A R GH  VV+ L+
Sbjct: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 63/204 (30%), Positives = 96/204 (47%), Gaps = 6/204 (2%)

Query: 84  LHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVN 143
           L  A   G  + V  LL      N    +G   L LA   G  ++ ++L+     H  V 
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM---HANVE 294

Query: 144 EQNNDNE-TALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLL 202
           ++    + T L  AA  GH ++VK+LL    D   +++   T L  A   G ++VVK+LL
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354

Query: 203 NAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKT 260
            +  ++   N   HTPL  A   GH  V ++LL+  AG++++      SAL  A   G  
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 261 DVVQILLAAGTDVNIKDNHGLTAL 284
           ++V+ LL AG D   K +   TAL
Sbjct: 415 EMVRFLLEAGADQEHKTDEMHTAL 438



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 55/141 (39%), Positives = 68/141 (48%), Gaps = 2/141 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NV+   +TG T L +A  NGH DV +VLL+  A        G  PL  AA  G    V
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + LI +G +  R    N+    +L CA   GH  VV++LL    DPT R     T L  A
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAG--GHLAVVELLLAHGADPTHRLKDGSTMLIEA 704

Query: 190 ALYGRLEVVKMLLNAHPNLLS 210
           A  G   VV  LL+   NLLS
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLS 725



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 88/317 (27%), Positives = 130/317 (41%), Gaps = 45/317 (14%)

Query: 29  SSGFGGGGGGGSGGGGGGSGGGGGGLGSSSH-------------PLSSLLSMWRGPNVNC 75
           SS         SGGGGGG GGGGGG G+SS+              +S + S     + + 
Sbjct: 84  SSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFIL--DQDD 141

Query: 76  VDSTGYTPLHHAALNGHKDVV-------EVLLRNDALTNVADSKGCYPLHLAAWK--GDA 126
           +++          L+G  D         E   R +AL   A   G   L  A  K   D 
Sbjct: 142 LENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA---GIGKLSTADGKAFADP 198

Query: 127 QIVRLLI--------HQGPSHTRVNEQNNDN-----ETALHCAAQYGHTEVVKVLLEELT 173
           +++R L             + TR+  ++  N       +L  A   G    V+ LL E  
Sbjct: 199 EVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGR 258

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH-TPLHLAARNGHKAVVQ 232
                  + E+ L LA   G  E+ ++LL  H N+     K   TPL  AA  GH  +V+
Sbjct: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVK 318

Query: 233 VLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELP 291
           +LL    D N Q+  G +AL  A   G  DVV++LL +G  +   + +G T L    E  
Sbjct: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPL---MEAG 375

Query: 292 SQKSQQIAALIEDHMTG 308
           S    ++A L+ ++  G
Sbjct: 376 SAGHVEVARLLLENGAG 392



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 6/92 (6%)

Query: 65   LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
            L + RG +++  +  G TPL  AA  GH DVV++L++  A  + AD++   PL  A  KG
Sbjct: 1087 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1146

Query: 125  DAQIVRLLIHQGPSHTRVNEQNNDNETALHCA 156
              ++VR L+ +      VN+  +D+E   + A
Sbjct: 1147 HVKVVRYLVKE------VNQFPSDSECMRYIA 1172


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score =  112 bits (280), Expect = 2e-24
 Identities = 93/278 (33%), Positives = 129/278 (46%), Gaps = 23/278 (8%)

Query: 56   SSSHPLSSLLSMWRGPNVNCVDSTGYTPLHH------AALNGHKDVVEVLLRNDALTNVA 109
            S S   S++ S    P    VD   +T  +H      A   GH+++V VL+  DA     
Sbjct: 1025 SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHR 1084

Query: 110  DSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL 169
            D KG  PL LAA  G   +V +L+ +G      +E+  D   +L C+   G  EVV +LL
Sbjct: 1085 DKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSG--GRQEVVDLLL 1142

Query: 170  EELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK--HTPLHLAARNGH 227
                +   RN    TPL LAA  G + ++K+LLNA   + S    K   +PL LAA NGH
Sbjct: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202

Query: 228  KAVVQVLLDAGMDSNYQ--TEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALD 285
               V++LLD G D N Q  T   +AL  A   G+ +VV +LL    +V  +   GLT L 
Sbjct: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL- 1261

Query: 286  TVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQP 323
               E  S    ++  ++ D        K  D   PP P
Sbjct: 1262 --MEAASGGYAEVGRVLLD--------KGADVNAPPVP 1289



 Score =  108 bits (270), Expect = 3e-23
 Identities = 74/209 (35%), Positives = 108/209 (51%), Gaps = 6/209 (2%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP-LHLAAWKGDAQI 128
           G N+   +  G+TPL  AA  GH +V  VLL + A  N   ++     L LA +KG   +
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VR L+  G        + ++  TAL  A   GH EV ++LL+      M  + FE+PL L
Sbjct: 388 VRFLLEAGADQ---EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE-- 246
           AA  G +E+  +L+    NL   N + +TPL  AAR GH+ +V +LL  G + N QTE  
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 247 MGSALHEAALFGKTDVVQILLAAGTDVNI 275
             +AL  A   G ++V   L+ AG D+ +
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIEL 533



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 97/328 (29%), Positives = 144/328 (43%), Gaps = 43/328 (13%)

Query: 59  HPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTN----------- 107
           H   + L + RG N+  V+  GYTPL  AA  GH+++V +LL   A  N           
Sbjct: 450 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509

Query: 108 ----------VAD---------SKGC-YPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNN 147
                     VAD           GC  PL  A+ +G  ++V+ L+  G     V+    
Sbjct: 510 TLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG---ANVHATTA 566

Query: 148 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLN--AH 205
             +TAL  A + GHT+V  VLL+   D    +    TPL  AA  G L  V+ L++  A+
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626

Query: 206 PNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQ 264
            N  + N   HT + LA   GH AVV++LL  G D  ++ + GS  L EAA  G T+VV 
Sbjct: 627 VNRATAN-NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVS 685

Query: 265 ILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPP-QP 323
            LL    +V       ++ L      PSQ   Q+  +    +      +E D+T     P
Sbjct: 686 YLLDYPNNVLSVPTTDVSQLPP----PSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSP 741

Query: 324 PLISSMDSISQKSQGDVEKAVTELIIDF 351
            L+      S++    ++ A  +L+  F
Sbjct: 742 ALLGVQKGTSKQKSSSLQVADQDLLPSF 769



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 71/207 (34%), Positives = 104/207 (50%), Gaps = 8/207 (3%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  VN    +  +PL  AA  GH ++  +L+   A     + +G  PL  AA +G  ++V
Sbjct: 428 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487

Query: 130 RLLIHQGPSHTRVNEQNNDN-ETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
            LL+ QG +   +N Q  +  ETAL  A   G +EV   L++   D  +  +   TPL  
Sbjct: 488 ALLLAQGAN---INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLME 541

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           A+  G LE+VK LL +  N+ +      T L  A  NGH  V  VLL AG D  +++E G
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVN 274
            + L +AA  G    VQ L++ G +VN
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVN 628



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 69/226 (30%), Positives = 105/226 (46%), Gaps = 6/226 (2%)

Query: 62  SSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAA 121
           ++ L+  +  N +         L  A  +G  + V  LL      N    +G   L LA 
Sbjct: 187 AAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246

Query: 122 WKGDAQIVRLLIHQGPSHTRVNEQNNDNE-TALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
             G  ++ ++L+     H  V ++ N  + T L  A+  G+ ++VK+LL    D   ++ 
Sbjct: 247 SAGYYELAQVLLAM---HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303

Query: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD--AG 238
              T L  A   G +++VK+LLN   N+   N   HTPL  AA  GH  V +VLLD  AG
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363

Query: 239 MDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           ++++      SAL  A   G  D+V+ LL AG D   K +   TAL
Sbjct: 364 INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 70/259 (27%), Positives = 115/259 (44%), Gaps = 14/259 (5%)

Query: 70   GPNVNC-VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
            G ++N  +++   T L  A   G  +VV +LL   A        G  PL  AA  G A++
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272

Query: 129  VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
             R+L+ +G +        +  +TAL  AA  GH +  ++L+       +RN K  TPL L
Sbjct: 1273 GRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331

Query: 189  AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
            A+  G  +VV++L+ A  ++ + + +K TPL  A R GH  VVQ L+     + + +++ 
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE--VNQFPSDIE 1389

Query: 249  SALHEAALFGKTDVVQILLAAGTDVNIKDNHG----------LTALDTVRELPSQKSQQI 298
               + A +  K  + +      T V  KD             L  LD  +     + Q +
Sbjct: 1390 CMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQAL 1449

Query: 299  AALIEDHMTGKRSTKEVDK 317
            AA  E     ++  KE  K
Sbjct: 1450 AAKREKRKEKRKKKKEEQK 1468



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 89/317 (28%), Positives = 131/317 (41%), Gaps = 43/317 (13%)

Query: 29  SSGFGGGGGGGSGGGGGG---------------SGGGGGGLGSSSHPLSSLLSM---WRG 70
           +SG G  GGGGSG G GG               +GGGGG  GS    +S + S       
Sbjct: 53  ASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQED 112

Query: 71  PNVNCVDSTGYTPLHHAALNGHKDVV--EVLLRNDALTNVADSKGCYPLHLAAWK--GDA 126
            +   + +T    L   A       V  E   R +AL   A   G   L  A  K   D 
Sbjct: 113 LDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA---GIGKLSTADGKAFADP 169

Query: 127 QIVRLLI--------HQGPSHTRVNEQNNDN-----ETALHCAAQYGHTEVVKVLLEELT 173
           +++R L             + TR+  +N+ N       +L  A   G    V+ LL+E  
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH-TPLHLAARNGHKAVVQ 232
                  + E+ L LA   G  E+ ++LL  H N+     K   TPL  A+  G+  +V+
Sbjct: 230 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 289

Query: 233 VLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELP 291
           +LL    D N Q+  G +AL  A   G  D+V++LL  G ++   + +G T L    E  
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL---MEAA 346

Query: 292 SQKSQQIAALIEDHMTG 308
           S    ++A ++ DH  G
Sbjct: 347 SAGHVEVARVLLDHGAG 363



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 65/213 (30%), Positives = 85/213 (39%), Gaps = 46/213 (21%)

Query: 1   MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
           +G    L+EA++ GHL  V+ LL+                                    
Sbjct: 533 LGCSTPLMEASQEGHLELVKYLLAS----------------------------------- 557

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
                    G NV+   +TG T L +A  NGH DV +VLL+  A        G  PL  A
Sbjct: 558 ---------GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           A  G    V+ LI +G +  R    N+    +L CA   GH  VV++LL    DPT R  
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG--GHLAVVELLLAHGADPTHRLK 666

Query: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNT 213
              T L  AA  G   VV  LL+   N+LS  T
Sbjct: 667 DGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPT 699



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 41/139 (29%), Positives = 67/139 (48%), Gaps = 12/139 (8%)

Query: 69   RGPNVNC--VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDA 126
            +G +VN   V S+  T L  AA  GH    E+L+   A  +V + KG  PL LA+  G  
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338

Query: 127  QIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPL 186
             +V+LL+  G     V+  +N   T L  A + GH +VV+ L++E+       N+F + +
Sbjct: 1339 DVVQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLVKEV-------NQFPSDI 1388

Query: 187  DLAALYGRLEVVKMLLNAH 205
            +       +   ++L   H
Sbjct: 1389 ECMRYIATITDKELLKKCH 1407



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 24/71 (33%), Positives = 42/71 (59%)

Query: 65   LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
            L + RG +++  +  G TPL  A+  GH DVV++L++  A  + AD++   PL  A  KG
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369

Query: 125  DAQIVRLLIHQ 135
              ++V+ L+ +
Sbjct: 1370 HVKVVQYLVKE 1380


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  112 bits (280), Expect = 2e-24
 Identities = 93/278 (33%), Positives = 129/278 (46%), Gaps = 23/278 (8%)

Query: 56   SSSHPLSSLLSMWRGPNVNCVDSTGYTPLHH------AALNGHKDVVEVLLRNDALTNVA 109
            S S   S++ S    P    VD   +T  +H      A   GH+++V VL+  DA     
Sbjct: 1025 SCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHR 1084

Query: 110  DSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL 169
            D KG  PL LAA  G   +V +L+ +G      +E+  D   +L C+   G  EVV +LL
Sbjct: 1085 DKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSG--GRQEVVDLLL 1142

Query: 170  EELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKK--HTPLHLAARNGH 227
                +   RN    TPL LAA  G + ++K+LLNA   + S    K   +PL LAA NGH
Sbjct: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202

Query: 228  KAVVQVLLDAGMDSNYQ--TEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALD 285
               V++LLD G D N Q  T   +AL  A   G+ +VV +LL    +V  +   GLT L 
Sbjct: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL- 1261

Query: 286  TVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQP 323
               E  S    ++  ++ D        K  D   PP P
Sbjct: 1262 --MEAASGGYAEVGRVLLD--------KGADVNAPPVP 1289



 Score =  108 bits (270), Expect = 3e-23
 Identities = 74/209 (35%), Positives = 108/209 (51%), Gaps = 6/209 (2%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYP-LHLAAWKGDAQI 128
           G N+   +  G+TPL  AA  GH +V  VLL + A  N   ++     L LA +KG   +
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VR L+  G        + ++  TAL  A   GH EV ++LL+      M  + FE+PL L
Sbjct: 388 VRFLLEAGADQ---EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE-- 246
           AA  G +E+  +L+    NL   N + +TPL  AAR GH+ +V +LL  G + N QTE  
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 247 MGSALHEAALFGKTDVVQILLAAGTDVNI 275
             +AL  A   G ++V   L+ AG D+ +
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIEL 533



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 97/328 (29%), Positives = 144/328 (43%), Gaps = 43/328 (13%)

Query: 59  HPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTN----------- 107
           H   + L + RG N+  V+  GYTPL  AA  GH+++V +LL   A  N           
Sbjct: 450 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509

Query: 108 ----------VAD---------SKGC-YPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNN 147
                     VAD           GC  PL  A+ +G  ++V+ L+  G     V+    
Sbjct: 510 TLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG---ANVHATTA 566

Query: 148 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLN--AH 205
             +TAL  A + GHT+V  VLL+   D    +    TPL  AA  G L  V+ L++  A+
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626

Query: 206 PNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQ 264
            N  + N   HT + LA   GH AVV++LL  G D  ++ + GS  L EAA  G T+VV 
Sbjct: 627 VNRATAN-NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVS 685

Query: 265 ILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPP-QP 323
            LL    +V       ++ L      PSQ   Q+  +    +      +E D+T     P
Sbjct: 686 YLLDYPNNVLSVPTTDVSQLPP----PSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSP 741

Query: 324 PLISSMDSISQKSQGDVEKAVTELIIDF 351
            L+      S++    ++ A  +L+  F
Sbjct: 742 ALLGVQKGTSKQKSSSLQVADQDLLPSF 769



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 71/207 (34%), Positives = 104/207 (50%), Gaps = 8/207 (3%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  VN    +  +PL  AA  GH ++  +L+   A     + +G  PL  AA +G  ++V
Sbjct: 428 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487

Query: 130 RLLIHQGPSHTRVNEQNNDN-ETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
            LL+ QG +   +N Q  +  ETAL  A   G +EV   L++   D  +  +   TPL  
Sbjct: 488 ALLLAQGAN---INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLME 541

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           A+  G LE+VK LL +  N+ +      T L  A  NGH  V  VLL AG D  +++E G
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601

Query: 249 -SALHEAALFGKTDVVQILLAAGTDVN 274
            + L +AA  G    VQ L++ G +VN
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVN 628



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 69/226 (30%), Positives = 105/226 (46%), Gaps = 6/226 (2%)

Query: 62  SSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAA 121
           ++ L+  +  N +         L  A  +G  + V  LL      N    +G   L LA 
Sbjct: 187 AAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246

Query: 122 WKGDAQIVRLLIHQGPSHTRVNEQNNDNE-TALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
             G  ++ ++L+     H  V ++ N  + T L  A+  G+ ++VK+LL    D   ++ 
Sbjct: 247 SAGYYELAQVLLAM---HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303

Query: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD--AG 238
              T L  A   G +++VK+LLN   N+   N   HTPL  AA  GH  V +VLLD  AG
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363

Query: 239 MDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           ++++      SAL  A   G  D+V+ LL AG D   K +   TAL
Sbjct: 364 INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 70/259 (27%), Positives = 115/259 (44%), Gaps = 14/259 (5%)

Query: 70   GPNVNC-VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
            G ++N  +++   T L  A   G  +VV +LL   A        G  PL  AA  G A++
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272

Query: 129  VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
             R+L+ +G +        +  +TAL  AA  GH +  ++L+       +RN K  TPL L
Sbjct: 1273 GRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331

Query: 189  AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
            A+  G  +VV++L+ A  ++ + + +K TPL  A R GH  VVQ L+     + + +++ 
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE--VNQFPSDIE 1389

Query: 249  SALHEAALFGKTDVVQILLAAGTDVNIKDNHG----------LTALDTVRELPSQKSQQI 298
               + A +  K  + +      T V  KD             L  LD  +     + Q +
Sbjct: 1390 CMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQAL 1449

Query: 299  AALIEDHMTGKRSTKEVDK 317
            AA  E     ++  KE  K
Sbjct: 1450 AAKREKRKEKRKKKKEEQK 1468



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 89/317 (28%), Positives = 131/317 (41%), Gaps = 43/317 (13%)

Query: 29  SSGFGGGGGGGSGGGGGG---------------SGGGGGGLGSSSHPLSSLLSM---WRG 70
           +SG G  GGGGSG G GG               +GGGGG  GS    +S + S       
Sbjct: 53  ASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQED 112

Query: 71  PNVNCVDSTGYTPLHHAALNGHKDVV--EVLLRNDALTNVADSKGCYPLHLAAWK--GDA 126
            +   + +T    L   A       V  E   R +AL   A   G   L  A  K   D 
Sbjct: 113 LDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA---GIGKLSTADGKAFADP 169

Query: 127 QIVRLLI--------HQGPSHTRVNEQNNDN-----ETALHCAAQYGHTEVVKVLLEELT 173
           +++R L             + TR+  +N+ N       +L  A   G    V+ LL+E  
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 174 DPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH-TPLHLAARNGHKAVVQ 232
                  + E+ L LA   G  E+ ++LL  H N+     K   TPL  A+  G+  +V+
Sbjct: 230 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 289

Query: 233 VLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELP 291
           +LL    D N Q+  G +AL  A   G  D+V++LL  G ++   + +G T L    E  
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL---MEAA 346

Query: 292 SQKSQQIAALIEDHMTG 308
           S    ++A ++ DH  G
Sbjct: 347 SAGHVEVARVLLDHGAG 363



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 65/213 (30%), Positives = 85/213 (39%), Gaps = 46/213 (21%)

Query: 1   MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
           +G    L+EA++ GHL  V+ LL+                                    
Sbjct: 533 LGCSTPLMEASQEGHLELVKYLLAS----------------------------------- 557

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
                    G NV+   +TG T L +A  NGH DV +VLL+  A        G  PL  A
Sbjct: 558 ---------GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
           A  G    V+ LI +G +  R    N+    +L CA   GH  VV++LL    DPT R  
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG--GHLAVVELLLAHGADPTHRLK 666

Query: 181 KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNT 213
              T L  AA  G   VV  LL+   N+LS  T
Sbjct: 667 DGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPT 699



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 41/139 (29%), Positives = 67/139 (48%), Gaps = 12/139 (8%)

Query: 69   RGPNVNC--VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDA 126
            +G +VN   V S+  T L  AA  GH    E+L+   A  +V + KG  PL LA+  G  
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338

Query: 127  QIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPL 186
             +V+LL+  G     V+  +N   T L  A + GH +VV+ L++E+       N+F + +
Sbjct: 1339 DVVQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLVKEV-------NQFPSDI 1388

Query: 187  DLAALYGRLEVVKMLLNAH 205
            +       +   ++L   H
Sbjct: 1389 ECMRYIATITDKELLKKCH 1407



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 24/71 (33%), Positives = 42/71 (59%)

Query: 65   LSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKG 124
            L + RG +++  +  G TPL  A+  GH DVV++L++  A  + AD++   PL  A  KG
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369

Query: 125  DAQIVRLLIHQ 135
              ++V+ L+ +
Sbjct: 1370 HVKVVQYLVKE 1380


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  111 bits (278), Expect = 3e-24
 Identities = 72/217 (33%), Positives = 109/217 (50%), Gaps = 4/217 (1%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG  ++  D  G   ++ AA +GH D ++ L  N    +V D  G   LH+AA  G A +
Sbjct: 401 RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
            +LL   G   +  N Q+ + ET LHCAA +G+  V K L E   +  ++N + ETPL  
Sbjct: 461 AQLLCSFG---SNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLT 517

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG 248
           A+  G  ++V+ L     +L +C+   H  LHLA R     V++ LL  G   +YQ   G
Sbjct: 518 ASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHG 577

Query: 249 SA-LHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           +  LH A   G   +V  L  A  +++I + +G T L
Sbjct: 578 NTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPL 614



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 65/199 (32%), Positives = 88/199 (44%), Gaps = 3/199 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G N N  D    TPLH AA +G+  V + L       N+ + +G  PL  A+ +G   IV
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 527

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             L   G     +N  + D   ALH A +    EV+K LL +      ++    TPL +A
Sbjct: 528 ECLAEHGAD---LNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGS 249
              G + +V  L  A+ NL   N    TPLHLAA NG   VV+ L   G      T  G 
Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGK 644

Query: 250 ALHEAALFGKTDVVQILLA 268
              + A   + + V  LLA
Sbjct: 645 TAEDLARSEQHEHVAGLLA 663



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 55/173 (31%), Positives = 82/173 (47%), Gaps = 3/173 (1%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G NVN  +  G TPL  A+  G+ D+VE L  + A  N  D  G   LHLA  +   +++
Sbjct: 501 GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
           + L+ QG     V+ Q+    T LH A + G+  +V  L E   +  + N    TPL LA
Sbjct: 561 KTLLSQG---CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSN 242
           A  G L+VV+ L     ++ +  T   T   LA    H+ V  +L     D++
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTH 670



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 67/226 (29%), Positives = 100/226 (44%), Gaps = 50/226 (22%)

Query: 107 NVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVK 166
           N  +  G  PL +AA  G+ QI++LLI +G   +R++ Q+     A++ AA++GH + +K
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG---SRIDVQDKGGSNAVYWAARHGHVDTLK 429

Query: 167 VLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNG 226
            L E            + PLD+    G +                       LH+AAR G
Sbjct: 430 FLSEN-----------KCPLDVKDKSGEMA----------------------LHVAARYG 456

Query: 227 HKAVVQVLLDAGMDSNYQT-EMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALD 285
           H  V Q+L   G + N Q  E  + LH AA  G   V + L  AG +VNIK+  G T L 
Sbjct: 457 HADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLL 516

Query: 286 T--------VRELPSQKSQQIAALIED-----HMTGKRSTKEVDKT 318
           T        + E  ++    + A  +D     H+  +R   EV KT
Sbjct: 517 TASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKT 562



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 36/108 (33%), Positives = 51/108 (47%), Gaps = 5/108 (4%)

Query: 61  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
           + +LLS  +G  V+  D  G TPLH A  +G+  +V  L   +   ++++  G  PLHLA
Sbjct: 560 IKTLLS--QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617

Query: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVL 168
           A  G   +VR L   G S   V     D +TA   A    H  V  +L
Sbjct: 618 ANNGILDVVRYLCLMGAS---VEALTTDGKTAEDLARSEQHEHVAGLL 662


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  110 bits (275), Expect = 8e-24
 Identities = 76/229 (33%), Positives = 121/229 (52%), Gaps = 16/229 (6%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKG-------CYPLH--- 118
           R  N    +  G   LH AA  GH+  V +LL ++A  +  D+ G       C+ ++   
Sbjct: 37  RRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALL 96

Query: 119 LAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMR 178
           L+AW G  +I+++L++ G    +++ ++ D  T LHCAAQ GH  V+  ++E+L D  + 
Sbjct: 97  LSAWFGHLRILQILVNSG---AKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153

Query: 179 --NNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD 236
             +    T    AA +G+L+ +  L+ +  +    + + +T LHLAA  GH AV+Q L+D
Sbjct: 154 HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213

Query: 237 AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
            G+D   Q   G +ALH AA     D VQ+LL AG+ VN      L+ L
Sbjct: 214 IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCL 262



 Score =  103 bits (258), Expect = 7e-22
 Identities = 71/210 (33%), Positives = 110/210 (52%), Gaps = 4/210 (1%)

Query: 76  VDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQ 135
           VD  G T  H AA +G  D ++ L+ +    NV D +G   LHLAA +G   +++ L+  
Sbjct: 155 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDI 214

Query: 136 GPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRL 195
           G     + EQN +  TALH AA   H + V++LL   +       K  + L  AAL G  
Sbjct: 215 G---LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSE 271

Query: 196 EVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSN-YQTEMGSALHEA 254
           +V ++L++A       + +  +PLHLA R+   A+V++L+++  D N       + LH A
Sbjct: 272 DVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLA 331

Query: 255 ALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           A     D+  +LL AG D+N++D  G TAL
Sbjct: 332 AEHAWQDIADMLLIAGVDLNLRDKQGKTAL 361



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 60/196 (30%), Positives = 92/196 (46%), Gaps = 16/196 (8%)

Query: 10  AARTGHLPAVEKLLS-GKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMW 68
           AA  GH+  +++L+  G  L      G        GG            SHP    L + 
Sbjct: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGG------------SHPDCVQLLLR 246

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
            G  VN +     + LH+AAL+G +DV  VL+      NV D +G  PLHLA       +
Sbjct: 247 AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPAL 306

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           VRLLI+   S + VN  +N  +T LH AA++   ++  +LL    D  +R+ + +T L +
Sbjct: 307 VRLLIN---SDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAV 363

Query: 189 AALYGRLEVVKMLLNA 204
           A     + +V M++ A
Sbjct: 364 AVRSNHVSLVDMIIKA 379



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 52/184 (28%)

Query: 150 ETALHCAAQY---------------------------------GHTEVVKVLLEE----- 171
           E  LH AA+                                  GH + V++LLE      
Sbjct: 16  ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75

Query: 172 -------LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH-TPLHLAA 223
                  LT+  +        L L+A +G L ++++L+N+    + C +K   T LH AA
Sbjct: 76  EEDAVGALTEARLCFGM--NALLLSAWFGHLRILQILVNSGAK-IHCESKDGLTLLHCAA 132

Query: 224 RNGHKAVVQVLLDAGMD--SNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHG 280
           + GH  V+  +++   D   ++  ++G +A H AA  G+ D +  L+ +G D N+KD  G
Sbjct: 133 QKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192

Query: 281 LTAL 284
            TAL
Sbjct: 193 NTAL 196



 Score = 37.4 bits (85), Expect = 0.081
 Identities = 34/126 (26%), Positives = 55/126 (43%), Gaps = 11/126 (8%)

Query: 170 EELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKA 229
           EEL   T      E  L  AA    +  ++ L+    N  + N      LH AA  GH+ 
Sbjct: 3   EELAWETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQ 62

Query: 230 VVQVLLDAGMDSNYQTEMG-----------SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
            V++LL+     + +  +G           +AL  +A FG   ++QIL+ +G  ++ +  
Sbjct: 63  AVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESK 122

Query: 279 HGLTAL 284
            GLT L
Sbjct: 123 DGLTLL 128


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  109 bits (273), Expect = 1e-23
 Identities = 104/377 (27%), Positives = 166/377 (44%), Gaps = 57/377 (15%)

Query: 69   RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
            RG + N  D  G+TPLH AA  GH+ + E L+   A TN  D+ G  P  LA+ +G    
Sbjct: 836  RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDC 895

Query: 129  VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTD---------PTMRN 179
            V++L+    + + ++++  D   AL  AA  GH ++V++L     D         PT+  
Sbjct: 896  VQILLE---NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYI 952

Query: 180  NKFETPLDLAALY------------------------GRLEVVKMLLNAHPNLLSCNTKK 215
               E  L +A  +                        G +E+V++L+  H ++ + + +K
Sbjct: 953  LALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012

Query: 216  HTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVN 274
             + L  AA  GH  VVQ+L++ G   ++    G +AL  AA  G  DVVQ+LL  G D N
Sbjct: 1013 RSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN 1072

Query: 275  IKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTP------PPQPPLISS 328
              D  G TA+   R        QI  L+E +  G  S      +P       P   L S 
Sbjct: 1073 HADQFGRTAM---RVAAKNGHSQIIKLLEKY--GASSLNGCSPSPVHTMEQKPLQSLSSK 1127

Query: 329  MDSISQKSQ-------GDVEKAVTELI--IDFDANAEEEGPYEALYNAISCHSLDSMASG 379
            + S++ KS        GD++ ++  L        ++  E P   +    S  S +S+ S 
Sbjct: 1128 VQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSS 1187

Query: 380  RSSDQDSTNKEAEAAGV 396
            ++S   +T+  A A  V
Sbjct: 1188 KNSSLRTTSSTATAQTV 1204



 Score =  109 bits (272), Expect = 2e-23
 Identities = 78/230 (33%), Positives = 114/230 (49%), Gaps = 4/230 (1%)

Query: 56  SSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY 115
           S  H     L + RG  V+  D  G TPL  AA  GH DVV++LL   A  +  D+ G  
Sbjct: 724 SKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRT 783

Query: 116 PLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDP 175
           PL  AA  G A +V  L+  G +   V+  +++  T L  A+  G+ EVV+ LL+   D 
Sbjct: 784 PLLAAASMGHASVVNTLLFWGAA---VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840

Query: 176 TMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLL 235
             R++   TPL +AA  G   + + L+         +     P  LA++ GH   VQ+LL
Sbjct: 841 NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900

Query: 236 DAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
           +   + + +   G +AL  AAL G  D+V++L + G DVN KD  G   L
Sbjct: 901 ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950



 Score =  108 bits (270), Expect = 3e-23
 Identities = 93/282 (32%), Positives = 133/282 (47%), Gaps = 22/282 (7%)

Query: 10  AARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMWR 69
           AAR GH   V  L+         G G         G +       G  +  +S+LL  + 
Sbjct: 585 AARQGHTKVVNCLI---------GCGANINHTDQDGWTALRSAAWGGHTEVVSALL--YA 633

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G  V+C D+   T L  AA  GH+D+V  LL++ A  N AD++G   L  AA+ G  +IV
Sbjct: 634 GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIV 693

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCA-----AQYGHTEVVKVLLEELTDPTMRNNKFET 184
             L+  G     VN ++ D  TAL  A     A  GH  VV +L++   +    +    T
Sbjct: 694 EHLLDHG---AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMT 750

Query: 185 PLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLL--DAGMDSN 242
           PL +AA  G ++VV +LL    ++   +    TPL  AA  GH +VV  LL   A +DS 
Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS- 809

Query: 243 YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             +E  + L  A+  G  +VV+ LL  G D N +D+ G T L
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851



 Score =  106 bits (265), Expect = 1e-22
 Identities = 77/222 (34%), Positives = 113/222 (50%), Gaps = 9/222 (4%)

Query: 69  RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
           RG ++   D+ G+TPL  AA  GH  VV  L+   A  N  D  G   L  AAW G  ++
Sbjct: 567 RGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEV 626

Query: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
           V  L++ G    +V+  + D+ TAL  AA  GH ++V  LL+   +    +N+  T L  
Sbjct: 627 VSALLYAG---VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683

Query: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLA-----ARNGHKAVVQVLLDAGMDSNY 243
           AA  G  E+V+ LL+    +   +    T L +A     A  GH +VV +L+D G + ++
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743

Query: 244 QTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
             + G + L  AA  G  DVV +LL  G DV+  DN+G T L
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785



 Score =  105 bits (262), Expect = 2e-22
 Identities = 80/217 (36%), Positives = 109/217 (50%), Gaps = 9/217 (4%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAW-----KG 124
           G  VN  D+ G T L  AA  GH+++VE LL + A  N  D  G   L +AA      KG
Sbjct: 667 GAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKG 726

Query: 125 DAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFET 184
            A +V LLI +G     V+  + D  T L  AA  GH +VV +LLE   D    +N   T
Sbjct: 727 HASVVSLLIDRG---AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRT 783

Query: 185 PLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ 244
           PL  AA  G   VV  LL     + S +++  T L +A+  G+  VV+ LLD G+D N++
Sbjct: 784 PLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHR 843

Query: 245 TEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHG 280
            + G + LH AA  G   + + L+  G   N  DN G
Sbjct: 844 DDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880



 Score =  101 bits (251), Expect = 5e-21
 Identities = 79/221 (35%), Positives = 109/221 (49%), Gaps = 9/221 (4%)

Query: 70  GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
           G +VN  DS G T L +AA +G  DVV +L+   A   + D+ G  PL LAA +G  ++V
Sbjct: 535 GASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594

Query: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
             LI  G     +N  + D  TAL  AA  GHTEVV  LL         +    T L  A
Sbjct: 595 NCLIGCG---ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651

Query: 190 ALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG- 248
           A  G  ++V  LL     +   + +  T L  AA  GH+ +V+ LLD G + N++   G 
Sbjct: 652 AWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGR 711

Query: 249 SALHEAALF-----GKTDVVQILLAAGTDVNIKDNHGLTAL 284
           +AL  AAL      G   VV +L+  G +V+  D  G+T L
Sbjct: 712 TALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPL 752



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 63/193 (32%), Positives = 95/193 (49%), Gaps = 6/193 (3%)

Query: 93  KDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETA 152
           ++V+++L++  A  N  D +    +  A  + D+  +R L+  G S   VN+ +++  T 
Sbjct: 494 QEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDNGAS---VNQCDSNGRTL 548

Query: 153 LHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCN 212
           L  AA  G  +VV +L+    D  + +    TPL LAA  G  +VV  L+    N+   +
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608

Query: 213 TKKHTPLHLAARNGHKAVVQVLLDAGMDSN-YQTEMGSALHEAALFGKTDVVQILLAAGT 271
               T L  AA  GH  VV  LL AG+  +    +  +AL  AA  G  D+V  LL  G 
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668

Query: 272 DVNIKDNHGLTAL 284
           +VN  DN G TAL
Sbjct: 669 EVNKADNEGRTAL 681


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.129    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,638,614
Number of Sequences: 37866
Number of extensions: 2523430
Number of successful extensions: 39704
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 766
Number of HSP's successfully gapped in prelim test: 287
Number of HSP's that attempted gapping in prelim test: 18866
Number of HSP's gapped (non-prelim): 9583
length of query: 1134
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1021
effective length of database: 13,968,660
effective search space: 14262001860
effective search space used: 14262001860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.