Search of human proteins with 7662022

Search of human proteins with 7662022

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7662022 lipin 2 [Homo sapiens]
         (896 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7662022 lipin 2 [Homo sapiens]                                    1821   0.0  
gi|22027648 lipin 1 [Homo sapiens]                                    867   0.0  
gi|74271888 lipin 3 [Homo sapiens]                                    805   0.0  
gi|104526627 triadin [Homo sapiens]                                    50   1e-05
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H...    42   0.002
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]             40   0.007
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]             40   0.007
gi|217330641 IWS1 homolog [Homo sapiens]                               40   0.013
gi|63252908 IQ motif and WD repeats 1 isoform a [Homo sapiens]         39   0.017
gi|4505913 PMS2 postmeiotic segregation increased 2 isoform a [H...    39   0.028
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    39   0.028
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    39   0.028
gi|112363080 microtubule associated serine/threonine kinase 2 [H...    38   0.037
gi|118600973 RNA binding motif protein, X-linked 2 [Homo sapiens]      38   0.037
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    38   0.048
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              37   0.063
gi|63252910 IQ motif and WD repeats 1 isoform b [Homo sapiens]         37   0.082
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa...    37   0.082
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa...    37   0.082
gi|145580626 E2F transcription factor 7 [Homo sapiens]                 37   0.082
gi|27734897 hypothetical protein LOC203111 [Homo sapiens]              37   0.082
gi|23308722 TTK protein kinase [Homo sapiens]                          36   0.14 
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap...    36   0.14 
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    36   0.14 
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    36   0.14 
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    36   0.14 
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    36   0.14 
gi|210032580 SET domain containing 1B [Homo sapiens]                   36   0.14 
gi|33356179 transcription termination factor, RNA polymerase I [...    36   0.18 
gi|168229156 NFKB activating protein [Homo sapiens]                    36   0.18 

>gi|7662022 lipin 2 [Homo sapiens]
          Length = 896

 Score = 1821 bits (4718), Expect = 0.0
 Identities = 896/896 (100%), Positives = 896/896 (100%)

Query: 1   MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS 60
           MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS
Sbjct: 1   MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS 60

Query: 61  KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT 120
           KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT
Sbjct: 61  KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT 120

Query: 121 PLVKSGGDETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDT 180
           PLVKSGGDETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDT
Sbjct: 121 PLVKSGGDETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDT 180

Query: 181 CDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTAC 240
           CDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTAC
Sbjct: 181 CDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTAC 240

Query: 241 PKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRV 300
           PKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRV
Sbjct: 241 PKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRV 300

Query: 301 IPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLD 360
           IPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLD
Sbjct: 301 IPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLD 360

Query: 361 ADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYF 420
           ADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYF
Sbjct: 361 ADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYF 420

Query: 421 PKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSEN 480
           PKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSEN
Sbjct: 421 PKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSEN 480

Query: 481 GEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPK 540
           GEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPK
Sbjct: 481 GEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPK 540

Query: 541 ATVESWVKDKMPKKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPA 600
           ATVESWVKDKMPKKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPA
Sbjct: 541 ATVESWVKDKMPKKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPA 600

Query: 601 ENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSSDQIAKLKLHDGPNDVVF 660
           ENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSSDQIAKLKLHDGPNDVVF
Sbjct: 601 ENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSSDQIAKLKLHDGPNDVVF 660

Query: 661 SITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQILPQLGKDWTHQGIAKLY 720
           SITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQILPQLGKDWTHQGIAKLY
Sbjct: 661 SITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQILPQLGKDWTHQGIAKLY 720

Query: 721 HSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIE 780
           HSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIE
Sbjct: 721 HSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIE 780

Query: 781 KKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQ 840
           KKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQ
Sbjct: 781 KKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQ 840

Query: 841 ERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPEVDLDDLS 896
           ERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPEVDLDDLS
Sbjct: 841 ERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPEVDLDDLS 896


>gi|22027648 lipin 1 [Homo sapiens]
          Length = 890

 Score =  867 bits (2239), Expect = 0.0
 Identities = 465/913 (50%), Positives = 615/913 (67%), Gaps = 46/913 (5%)

Query: 1   MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS 60
           MNYVGQLAGQV VTVKELYKG+N ATLSGCID+IV++Q +G+ QCSPFHVRFGK+GVLRS
Sbjct: 1   MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRS 60

Query: 61  KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT 120
           +EKV+DIEING +VDLHMKLGDNGEAFFV+ET+ + E +P +LATSPI +E      ++ 
Sbjct: 61  REKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGA--SRMEC 118

Query: 121 PLVKSGGDET----PSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDS-KKEEQAASA 175
            L +   D      PS  + +  +  +ET  + S VKK+++RR+K + DS K+++   ++
Sbjct: 119 QLKRGSVDRMRGLDPSTPAQV--IAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTS 176

Query: 176 AAEDTCDVGVSSDDDKGA-QAARGSSNA------SLKEEECKEPLLFHSGDHYPLSDGDW 228
             ED   + +SSD+     +++R   N        + EE     +++     YP SD +W
Sbjct: 177 EDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREW 236

Query: 229 SPLET-TYPQTACPKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRT 287
           SP  + +  + + PKSDSEL  K  E   +    M W WG  P++ K S   +       
Sbjct: 237 SPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPL 296

Query: 288 ATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLE 347
           ++    + +HF+ I SE +         +  D   T+V     AL  Q    T +  + E
Sbjct: 297 SSRKICDKSHFQAIHSESS--------DTFSDQSPTLVGG---ALLDQNKPQTEMQFVNE 345

Query: 348 PPLESTQISSMLDADHLPNAALAEAPSES--KPAAKVDSPSKKKGVHKRSQHQGPDDIYL 405
             LE+   ++ L    LP     + PS S  + A K DSPS+K+   KRS+H G D +YL
Sbjct: 346 EDLETLGAAAPL----LPMIEELKPPSASVVQTANKTDSPSRKRD--KRSRHLGADGVYL 399

Query: 406 DDLKGLEPEVAALYFPKSESEPG-SRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAM 464
           DDL  ++PEVAALYFPK+    G ++   ++   S +QSPQSVGS+  DSG E  SD   
Sbjct: 400 DDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLR 459

Query: 465 DLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALA 524
           DLP + +SLCGGLS++ EI+K+ F+E  ++Y +F +NP +ID+PNLV++I ++YYNW  A
Sbjct: 460 DLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTA 519

Query: 525 APMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWF-WRKRESMTKQLPESKEGKSEAPP 583
           AP++L++Q FQK LPKATVES ++DKMPKK GRWWF WR R +  K+  ESK  +  A  
Sbjct: 520 APLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTTIKE--ESKPEQCLAGK 577

Query: 584 ASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSS 643
           A        + + A   +++SSS +  +   +      +P  P       SYKK+LRL+S
Sbjct: 578 AHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLPLLP-----NVSYKKTLRLTS 632

Query: 644 DQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQI 703
           +Q+  LKL +GPNDVVFS+TTQYQGTCRC GTIYLWNW+DK+IISDIDGTIT+SD LG I
Sbjct: 633 EQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHI 692

Query: 704 LPQLGKDWTHQGIAKLYHSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPL 763
           LP LGKDWTHQGIAKLYH +++NGYKFLYCSARAIGMADMTRGYLHWVN++GT+LP+GPL
Sbjct: 693 LPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPL 752

Query: 764 MLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVG 823
           +LSPSSLFSA HREVIEKKPEKFK++CL DIKNLF P+ +PFYAAFGNRP DVY+Y QVG
Sbjct: 753 LLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVG 812

Query: 824 VPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPE-FSSFCY 882
           V   RIFTVNPKGEL+QE  K N SSY RL E+V+HVFPLL +  +S FPC + FS+F +
Sbjct: 813 VSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTF 872

Query: 883 WRDPIPEVDLDDL 895
           WR+P+P  +  D+
Sbjct: 873 WREPLPPFENQDI 885


>gi|74271888 lipin 3 [Homo sapiens]
          Length = 851

 Score =  805 bits (2079), Expect = 0.0
 Identities = 445/913 (48%), Positives = 582/913 (63%), Gaps = 81/913 (8%)

Query: 1   MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS 60
           MNYVGQLA  V  TVKELY+G+N ATLSG IDV+VV+Q DGS++CSPFHVRFGKLGVLRS
Sbjct: 1   MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRS 60

Query: 61  KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT 120
           +EKV+DIE+NG  VDLHMKLGD+GEAFFV+E E + E +P  L TSPIP           
Sbjct: 61  REKVVDIELNGEPVDLHMKLGDSGEAFFVQELESDDEHVPPGLCTSPIPW---------- 110

Query: 121 PLVKSGGDETPSQSSDISHVLETETIF---TPSSVKKKKRRRKKYKQDSKKEEQAASAAA 177
                GG       S +    E E +    T S+ ++K+RRR+K KQ   KE+  A+ ++
Sbjct: 111 -----GGLSGFPSDSQLGTASEPEGLVMAGTASTGRRKRRRRRKPKQ---KEDAVATDSS 162

Query: 178 EDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLET-TYP 236
            +  + G  S+     +         L+E+   +P      D YP SDG+W P  + +  
Sbjct: 163 PEELEAGAESELSLPEKLRPEPPGVQLEEKSSLQPK-----DIYPYSDGEWPPQASLSAG 217

Query: 237 QTACPKSDSELEVK-PAESLLRSESHMEWTWGGFPESTKVSKRERS---------DHHPR 286
           +   PKSDSELEV+ P  S LR+ESHM+W WG  P+  +  + E S            PR
Sbjct: 218 ELTSPKSDSELEVRTPEPSPLRAESHMQWAWGRLPKVARAERPESSVVLEGRAGATSPPR 277

Query: 287 TATITPSENTHFRVIPSEDNLISEVEKDASMEDTV--CTIVKPKPRALGTQMSDPTSVAE 344
               TPS +    V P     I + E  A ++      T+V P      T+ S   S  +
Sbjct: 278 GGPSTPSTSVAGGVDPL-GLPIQQTEAGADLQPDTEDPTLVGPPLHTPETEESKTQSSGD 336

Query: 345 LLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIY 404
           +  PP   +            + A  E P    P  + +  S+ KG  KRSQH GP DIY
Sbjct: 337 MGLPPASKSW-----------SWATLEVPV---PTGQPERVSRGKGSPKRSQHLGPSDIY 382

Query: 405 LDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAM 464
           LDDL  L+ E AALYFP+S+S  G+R+W E  +    + P            E   +  +
Sbjct: 383 LDDLPSLDSENAALYFPQSDSGLGARRWSEPSSQKSLRDPNP----------EHEPEPTL 432

Query: 465 DLPD-VTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWAL 523
           D  D + LSLCGGL+++ +IS EKF +H ++Y +  +NPGL+D+PNLV++I  ++YNWA+
Sbjct: 433 DTVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTKNPGLLDDPNLVVKINGKHYNWAV 492

Query: 524 AAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWF-WRKRESMTKQLPESKEGKSEAP 582
           AAPMILSLQ FQK+LPK+T++   ++KMP+K GRWWF WR+R+ + ++    KE      
Sbjct: 493 AAPMILSLQAFQKNLPKSTMDKLEREKMPRKGGRWWFSWRRRDFLAEERSAQKE------ 546

Query: 583 PASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLS 642
                 +++KE  G +      SSD+ + +    + +  +P  P +  ST +YKKSLRLS
Sbjct: 547 -----KTAAKEQQGEKTEV--LSSDDDAPDSPVILEIPSLP--PSTPPSTPTYKKSLRLS 597

Query: 643 SDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQ 702
           SDQI +L L +G NDVVFS+TTQYQGTCRC  TIYLW W+DK++ISDIDGTITKSDALG 
Sbjct: 598 SDQIRRLNLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDDKVVISDIDGTITKSDALGH 657

Query: 703 ILPQLGKDWTHQGIAKLYHSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGP 762
           ILPQLGKDWTHQGI  LYH I  NGYKFLYCSARAIGMAD+T+GYL WV++ G  LP+GP
Sbjct: 658 ILPQLGKDWTHQGITSLYHKIQLNGYKFLYCSARAIGMADLTKGYLQWVSEGGCSLPKGP 717

Query: 763 LMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQV 822
           ++LSPSSLFSA HREVIEKKPE FK+ CL+DI+ LF P  QPFYAAFGNRPNDV+AY QV
Sbjct: 718 ILLSPSSLFSALHREVIEKKPEVFKVACLSDIQQLFLPHGQPFYAAFGNRPNDVFAYRQV 777

Query: 823 GVPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCY 882
           G+P+ RIFTVNP+GELIQE  K +KS+Y RL E+VE +FP +++  ++    PE+S+FCY
Sbjct: 778 GLPESRIFTVNPRGELIQELIKNHKSTYERLGEVVELLFPPVARGPSTDLANPEYSNFCY 837

Query: 883 WRDPIPEVDLDDL 895
           WR+P+P VDLD L
Sbjct: 838 WREPLPAVDLDTL 850


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 82/363 (22%), Positives = 138/363 (38%), Gaps = 65/363 (17%)

Query: 127 GDETPSQSSDISHVLETETIFTPSSV----------KKKKRRR------KKYKQDSKKEE 170
           GD  P QS  I   L TE    P+            KKK  ++      KK K+D KK+ 
Sbjct: 280 GDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKS 339

Query: 171 QAASAAAEDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSP 230
           +  +A   +  + G +S+  +G    + ++ A+ K++E KE            S     P
Sbjct: 340 EKETAIDVEKKEPGKASETKQG--TVKIAAQAAAKKDEKKED-----------SKKTKKP 386

Query: 231 LETTYPQTACPKSDSELEVKPAESLLRSESHMEWTWGGFPESTKV-SKRERSDHHPRTAT 289
            E   P+    +   E  V+PA+S  +  S         P   +V +K ER+       +
Sbjct: 387 AEVEQPK-GKKQEKKEKHVEPAKSPKKEHS--------VPSDKQVKAKTERAKEEIGAVS 437

Query: 290 ITPSENTHFRVIP--SEDNLISEVEKDASMEDT--VCTIVKPKPRALGTQMSDPTSVAEL 345
           I        + +P   E+     VE++   E +    +I+K K    G +   P S+ E 
Sbjct: 438 IK-------KAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKE- 489

Query: 346 LEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPSK-----KKGVHKRS----- 395
            EP  +  +  S    +  P     +   E KP  ++   +K     K  +HK+      
Sbjct: 490 KEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPE 549

Query: 396 ---QHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAA 452
               H  P++  L  +K +  E  A   P  ++E   R+ P   T     +P+   S   
Sbjct: 550 KTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGT-SEVT 608

Query: 453 DSG 455
           +SG
Sbjct: 609 ESG 611


>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
           sapiens]
          Length = 1094

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 64/269 (23%), Positives = 103/269 (38%), Gaps = 45/269 (16%)

Query: 102 YLATSPIPTEDQFFKDID---------TPLVKSGG--------DETPSQSSDISHVLETE 144
           +LA  P P  +  FKD D         T  +K+ G        +  P  S     V+E  
Sbjct: 598 FLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELA 657

Query: 145 TIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSNASL 204
             +TP+   K++   KK+  +S++EE ++ ++++   + G S   ++G     G SN   
Sbjct: 658 KEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESG-SESGEQGESGEEGDSNEDS 716

Query: 205 KEEECKEPLLFHSGDHYPLSDGDWSPLETTYP----QTACPKSDSELEVKPAESLLRSES 260
            E+         S        G  S LE          A  KSDSE   K  E    S+S
Sbjct: 717 SED---------SSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDS 767

Query: 261 HMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRVIPSEDNLISE----VEKDAS 316
             +       ES+ +   E S     + +   SE+   RV   ++    +    + KD S
Sbjct: 768 SND-------ESSSI---EDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVS 817

Query: 317 MEDTVCTIVKPKPRALGTQMSDPTSVAEL 345
           + D         P AL T    P+ +A+L
Sbjct: 818 LLDLDDFNPVSTPVALPTPALSPSLMADL 846


>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
          Length = 935

 Score = 40.4 bits (93), Expect = 0.007
 Identities = 57/249 (22%), Positives = 99/249 (39%), Gaps = 10/249 (4%)

Query: 257 RSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRVIPSEDNLISEVEKDAS 316
           +SE+H   T G FP +   S  E     P++   +P+ N           L S + +  +
Sbjct: 404 KSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPA 463

Query: 317 MEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSES 376
            E + C   +P     G+         E   P L++ + S+   A  +P+ +L +  S+S
Sbjct: 464 DELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSA---ARKMPSKSLEDISSDS 520

Query: 377 KPAAKVDSPSK---KKGVHKRSQHQGPDDIYL--DDLKGLEPEVAALYFPKSESEPGSRQ 431
              AKVD+  +   +      +    PD+ +   D LK +   V A    +S+       
Sbjct: 521 SNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTA 580

Query: 432 WPESDTLS-GSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEIS-KEKFM 489
              S  LS   +SP S+ + ++ SG   LS  +  +  V     G L   G I    +++
Sbjct: 581 SESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYV 640

Query: 490 EHIITYHEF 498
           E +   H F
Sbjct: 641 ESLKELHVF 649


>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
          Length = 934

 Score = 40.4 bits (93), Expect = 0.007
 Identities = 57/249 (22%), Positives = 99/249 (39%), Gaps = 10/249 (4%)

Query: 257 RSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRVIPSEDNLISEVEKDAS 316
           +SE+H   T G FP +   S  E     P++   +P+ N           L S + +  +
Sbjct: 403 KSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPA 462

Query: 317 MEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSES 376
            E + C   +P     G+         E   P L++ + S+   A  +P+ +L +  S+S
Sbjct: 463 DELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSA---ARKMPSKSLEDISSDS 519

Query: 377 KPAAKVDSPSK---KKGVHKRSQHQGPDDIYL--DDLKGLEPEVAALYFPKSESEPGSRQ 431
              AKVD+  +   +      +    PD+ +   D LK +   V A    +S+       
Sbjct: 520 SNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTA 579

Query: 432 WPESDTLS-GSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEIS-KEKFM 489
              S  LS   +SP S+ + ++ SG   LS  +  +  V     G L   G I    +++
Sbjct: 580 SESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYV 639

Query: 490 EHIITYHEF 498
           E +   H F
Sbjct: 640 ESLKELHVF 648


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 70/320 (21%), Positives = 119/320 (37%), Gaps = 42/320 (13%)

Query: 168 KEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSG---DHYPLS 224
           + +   +   +D  D G   +DD   Q + GS   S++     E      G    H+   
Sbjct: 10  QSDDGGATPVQDERDSGSDGEDDVNEQHS-GSDTGSVERHSENETSDREDGLPKGHHVTD 68

Query: 225 DGDWSPLETTYPQTACPK------SDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKR 278
             +  PL      +   +      SDSE E +       SE+      G   ES +  K 
Sbjct: 69  SENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKL 128

Query: 279 ERSDHHPR---TATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQ 335
             SD           + SEN      P+ D+ I E++K  + +      +KP       Q
Sbjct: 129 PGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP-------Q 181

Query: 336 MSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKV-DSPSKKKGVHKR 394
           +SD    +E  EPP      S   + +  P   ++++ SE  P  +V DS S++   H+ 
Sbjct: 182 ISD----SESEEPPRHQASDS---ENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQA 234

Query: 395 SQHQGPD--DIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAA 452
           S  +  +     + D +  +P       P+ ++     +      +S S+S     + A+
Sbjct: 235 SDSENEELPKPRISDSESEDP-------PRHQASDSENEELPKPRISDSESEDPPRNQAS 287

Query: 453 DSGTECL-----SDSAMDLP 467
           DS  E L     SDS  + P
Sbjct: 288 DSENEELPKPRVSDSESEGP 307


>gi|63252908 IQ motif and WD repeats 1 isoform a [Homo sapiens]
          Length = 880

 Score = 39.3 bits (90), Expect = 0.017
 Identities = 77/290 (26%), Positives = 119/290 (41%), Gaps = 37/290 (12%)

Query: 226 GDWSPLETTYPQTACPKSDSEL--EVKPAESLLRSESHMEWTWGGFPESTKV--SKRERS 281
           GDWS    T P+ A P+S+ E   E  P  SL++  S M   W  F E+++V  S R R 
Sbjct: 314 GDWSD---TGPR-ARPESERERDGEQSPNVSLMQRMSDMLSRW--FEEASEVAQSNRGRG 367

Query: 282 DHHPRTATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTS 341
              PR  T + S+ +    +PS  +L  EV + A   DT      P  + L    S   S
Sbjct: 368 RSRPRGGT-SQSDISTLPTVPSSPDL--EVSETAMEVDT------PAEQFLQPSTSSTMS 418

Query: 342 V-AELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPS----KKKGVHKRSQ 396
             A     P ES   + +L +         EA S      + DSPS    K+ G     +
Sbjct: 419 AQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA-SGHHTHHQSDSPSSVVNKQLGSMSLDE 477

Query: 397 HQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGT 456
            Q  ++  L    G    V +L++    +   + +   +D  S      S+ S++   G+
Sbjct: 478 QQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWS------SIASSSRGIGS 531

Query: 457 ECLSDSAMD--LPDVTLSLCGGLSENGEISKEKFMEHIITYHE--FAENP 502
            C S+   +  +P  ++    G SE    + E+  E +  Y E   AENP
Sbjct: 532 HCKSEGQEESFVPQSSVQPPEGDSETK--APEESSEDVTKYQEGVSAENP 579


>gi|4505913 PMS2 postmeiotic segregation increased 2 isoform a [Homo
           sapiens]
          Length = 862

 Score = 38.5 bits (88), Expect = 0.028
 Identities = 31/121 (25%), Positives = 47/121 (38%), Gaps = 1/121 (0%)

Query: 348 PPLESTQISSMLDADHLPNAALAEAPSESKP-AAKVDSPSKKKGVHKRSQHQGPDDIYLD 406
           P L + +    +    L  A      +E+KP + K   P +     KR          + 
Sbjct: 404 PSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAIS 463

Query: 407 DLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDL 466
           D   L P+  A+      S+P  R   E D+  GS S  S G +  D+G+ C S+ A   
Sbjct: 464 DKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASS 523

Query: 467 P 467
           P
Sbjct: 524 P 524


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 38.5 bits (88), Expect = 0.028
 Identities = 79/329 (24%), Positives = 121/329 (36%), Gaps = 47/329 (14%)

Query: 330 RALGTQMSDPTSVAELLE-------------PPLESTQISSMLDADHLPNAALAEAPSES 376
           +A  T++SDP S +E  E             P L ST  SS+L AD LP++   +A +E+
Sbjct: 72  QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTN-SSVLGAD-LPSSMKEKAKAET 129

Query: 377 KPAAKVDS----PSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQW 432
           + A K  +    P+  K V      + P        K  EP        ++E E GS   
Sbjct: 130 EKAGKTGNSMPHPATGKTVANLLSGKSPR-------KSAEPSANTTLVSETEEE-GS--- 178

Query: 433 PESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHI 492
                   +  P  V +  ADS +E  S S+ D  DV +            + EK ++  
Sbjct: 179 --VPAFGAAAKPGMVSAGQADSSSEDTSSSS-DETDVEVK-----------ASEKILQVR 224

Query: 493 ITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMP 552
                    PG    P    +            P   S    ++S          K  + 
Sbjct: 225 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 284

Query: 553 KK-SGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQ 611
            K SG+        +  K+ P  ++G + APP    P+ +K  AG R  ++ SSS+E   
Sbjct: 285 AKASGKTSQVGAASAPAKESP--RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 342

Query: 612 ELEESITVDPIPTEPLSHGSTTSYKKSLR 640
           E E      P    P    ++   K+S R
Sbjct: 343 EEEAPAQAKPSGKAPQVRAASAPAKESPR 371



 Score = 30.8 bits (68), Expect = 5.9
 Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 2/75 (2%)

Query: 553 KKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQE 612
           K SG+    R   +  K+ P  ++G + APP    P++++   G +  ++ SSS+E   +
Sbjct: 351 KPSGKAPQVRAASAPAKESP--RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSD 408

Query: 613 LEESITVDPIPTEPL 627
            E    ++    +PL
Sbjct: 409 REALAAMNAAQVKPL 423


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 38.5 bits (88), Expect = 0.028
 Identities = 79/329 (24%), Positives = 121/329 (36%), Gaps = 47/329 (14%)

Query: 330 RALGTQMSDPTSVAELLE-------------PPLESTQISSMLDADHLPNAALAEAPSES 376
           +A  T++SDP S +E  E             P L ST  SS+L AD LP++   +A +E+
Sbjct: 72  QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTN-SSVLGAD-LPSSMKEKAKAET 129

Query: 377 KPAAKVDS----PSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQW 432
           + A K  +    P+  K V      + P        K  EP        ++E E GS   
Sbjct: 130 EKAGKTGNSMPHPATGKTVANLLSGKSPR-------KSAEPSANTTLVSETEEE-GS--- 178

Query: 433 PESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHI 492
                   +  P  V +  ADS +E  S S+ D  DV +            + EK ++  
Sbjct: 179 --VPAFGAAAKPGMVSAGQADSSSEDTSSSS-DETDVEVK-----------ASEKILQVR 224

Query: 493 ITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMP 552
                    PG    P    +            P   S    ++S          K  + 
Sbjct: 225 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 284

Query: 553 KK-SGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQ 611
            K SG+        +  K+ P  ++G + APP    P+ +K  AG R  ++ SSS+E   
Sbjct: 285 AKASGKTSQVGAASAPAKESP--RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 342

Query: 612 ELEESITVDPIPTEPLSHGSTTSYKKSLR 640
           E E      P    P    ++   K+S R
Sbjct: 343 EEEAPAQAKPSGKAPQVRAASAPAKESPR 371



 Score = 30.8 bits (68), Expect = 5.9
 Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 2/75 (2%)

Query: 553 KKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQE 612
           K SG+    R   +  K+ P  ++G + APP    P++++   G +  ++ SSS+E   +
Sbjct: 351 KPSGKAPQVRAASAPAKESP--RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSD 408

Query: 613 LEESITVDPIPTEPL 627
            E    ++    +PL
Sbjct: 409 REALAAMNAAQVKPL 423


>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
            sapiens]
          Length = 1798

 Score = 38.1 bits (87), Expect = 0.037
 Identities = 37/155 (23%), Positives = 57/155 (36%), Gaps = 21/155 (13%)

Query: 532  QVFQKSLPKATVESWVKDKMPKKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSS 591
            +V Q   PK   ES  +D  P +  R        S+   +P    G +  PP  + PS  
Sbjct: 1528 EVSQSVAPKGAGESGEEDPFPSRDPR--------SLGPMVPSLLTGITLGPPRMESPSGP 1579

Query: 592  KEPAGARPA-ENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSSDQIAKLK 650
                G+  A E  +SS      L +S   DPIP E           K+  L +  +  L 
Sbjct: 1580 HRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPE--------GCWKAQHLHTQALTAL- 1630

Query: 651  LHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDKI 685
                P+    + T+        +G + +W+W   I
Sbjct: 1631 ---SPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLI 1662


>gi|118600973 RNA binding motif protein, X-linked 2 [Homo sapiens]
          Length = 322

 Score = 38.1 bits (87), Expect = 0.037
 Identities = 48/206 (23%), Positives = 83/206 (40%), Gaps = 25/206 (12%)

Query: 109 PTEDQFFKDIDTPLVKSG-GDETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSK 167
           P + +   D+   L + G G  TPS S   S   E  T       KK+K+++KK K+ + 
Sbjct: 118 PKDSEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKD-KKEKKKKKKEKEKAD 176

Query: 168 KEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGD 227
           +E QA   ++       V   DD G +     ++   ++ E +E      G   P S   
Sbjct: 177 REVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPRE------GQKLPKSRTA 230

Query: 228 WS--------PLETTYPQTACPKSDSELEVKPAESLLR-----SESHMEWTWG---GFPE 271
           +S         L+   P+    KS S  E +  ++ +R     S++H  W  G   G   
Sbjct: 231 YSGGAEDLERELKKEKPKHE-HKSSSRREAREEKTRIRDRGRSSDAHSSWYNGRSEGRSY 289

Query: 272 STKVSKRERSDHHPRTATITPSENTH 297
            ++   R++S  H R       E+++
Sbjct: 290 RSRSRSRDKSHRHKRARRSRERESSN 315


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 37.7 bits (86), Expect = 0.048
 Identities = 105/506 (20%), Positives = 180/506 (35%), Gaps = 50/506 (9%)

Query: 149 PSSVKKKKRRRKKYKQDSKKEEQA-----ASAAAEDTCDVGVSSDDDKGAQAARGSSNAS 203
           P + K KK+      +DS +EE+      A  AA     VG+      G  AA+ S ++S
Sbjct: 73  PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPP----GKAAAKASESSS 128

Query: 204 LKEEECKEPLLFHSGDHYPLSDGDWSPLET-TYPQTACPKSDSELEVKPAESLLRSESHM 262
            +E          S D     D    P++    PQ    K+  + + K ++S   S S  
Sbjct: 129 SEE----------SSDDDDEEDQKKQPVQKGVKPQAKAAKAPPK-KAKSSDSDSDSSSED 177

Query: 263 EWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRVIPSEDNLISEVEKDASMEDTVC 322
           E      P+ T V+ + ++   P+ A   P          S  +  S    D+  E    
Sbjct: 178 EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAA 237

Query: 323 TIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKV 382
           T  K  P+    Q+     V     P    T+ SS  +          + P ++KP    
Sbjct: 238 TPKKTVPKK---QVVAKAPVKAATTP----TRKSSSSEDSSSDEEEEQKKPMKNKPGPYS 290

Query: 383 DSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQ 442
             P       K+S    P    ++  + +E    +     S SE   +   ++     + 
Sbjct: 291 SVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATT 350

Query: 443 SPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENP 502
            P     AA  S     SDS+ D  D   S   G ++N         +        A   
Sbjct: 351 KPPPAKKAAESSSDSSDSDSSED--DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQ 408

Query: 503 GLIDNPNLVIRIYNRYYNW--ALAAPMILSLQVFQKSLPKATVESWVKDKMPKK------ 554
            +     L+ R  +   +   + ++    + ++   + PKAT ++ +   +P K      
Sbjct: 409 PVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALS--LPAKQAPQGS 466

Query: 555 ------SGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDE 608
                 S       + E  +K   + K  K     A   P+S+K+  G   + N SSSD+
Sbjct: 467 RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKK--GKAESSNSSSSDD 524

Query: 609 GSQELEESI--TVDPIPTEPLSHGST 632
            S+E EE +     P P  P ++G++
Sbjct: 525 SSEEEEEKLKGKGSPRPQAPKANGTS 550



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 78/401 (19%), Positives = 134/401 (33%), Gaps = 84/401 (20%)

Query: 90  EETEEEYEKLPAYLATSPIPTEDQFFKDIDTPLVKSGGDETPSQSSDISHVLETETI-FT 148
           ++ EE+ +K P      P        K    P  K+   ++ S SS      + +    T
Sbjct: 135 DDDEEDQKKQPVQKGVKPQA------KAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188

Query: 149 PSSVKKKKRRRKKYKQDSKKEEQAASAAAEDTCDVGVSSDDDKGAQAA------------ 196
           P +VK + +   K  + + K     +A++  +     SSDD +  +AA            
Sbjct: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQV 248

Query: 197 -------------RGSS----NASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTA 239
                        R SS    ++S +EEE K+P+    G +            ++ P  +
Sbjct: 249 VAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPY------------SSVPPPS 296

Query: 240 CPKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFR 299
            P     L  +P +  +  +  +E +     ES   S+ E+    P T  +     T   
Sbjct: 297 APPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKK---PPTKAVVSKATTK-- 351

Query: 300 VIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSML 359
             P      +E   D+S                    SD +   E    P  +T+ SS  
Sbjct: 352 --PPPAKKAAESSSDSS-------------------DSDSSEDDEAPSKPAGTTKNSSNK 390

Query: 360 DADHLPNAALAEAPSESKPAA--------KVDSPSKKKGVHKRSQHQGPDDIYLDDLKGL 411
            A    + A+  A +  +P          K DS S ++     S  +      +   K  
Sbjct: 391 PAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEE--ESSSSEEEKTKKMVATTKPK 448

Query: 412 EPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAA 452
               AAL  P  ++  GSR        S S+  +   S +A
Sbjct: 449 ATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA 489


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 37.4 bits (85), Expect = 0.063
 Identities = 70/357 (19%), Positives = 134/357 (37%), Gaps = 50/357 (14%)

Query: 125  SGGDETPSQSSDISHVL----------ETETIFTPSSVKKKKRRRKKYKQDSKKEE--QA 172
            +GGD+ P QS     +           E+E +  P +    +    + + +S+  E  +A
Sbjct: 1820 AGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEA 1879

Query: 173  ASAAAEDTCDVGVSS------DDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDG 226
               A  ++ DV           + +GA+A      A  + E  +   L   G+  P S+G
Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA--LETEGEDEPESEG 1937

Query: 227  DWSPLETTYPQTACPKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPR 286
                 E    + A    ++E + +P   ++ S+   E      PES  V   E       
Sbjct: 1938 ----AEAQEAEEAA--QEAEGQTQPESEVIESQEAEEEAQ---PESEDVEALEVEVETQE 1988

Query: 287  TATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELL 346
                   E+      P  +  + E E++A  E      V+ +P++ G +       A+ +
Sbjct: 1989 AEGEAQPESEDVEA-PEAEGEMQEAEEEAQPESDG---VEAQPKSEGEE-------AQEV 2037

Query: 347  EPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLD 406
            E   + T+       D  P +   EAP   + A + +   ++    +   H   +D+   
Sbjct: 2038 EGETQKTE------GDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEAHPESEDVDAQ 2088

Query: 407  DLKG-LEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDS 462
            + +G  +PE   +  P++E E    +  E+    G   P+S G  A ++  E   +S
Sbjct: 2089 EAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPES 2145


>gi|63252910 IQ motif and WD repeats 1 isoform b [Homo sapiens]
          Length = 860

 Score = 37.0 bits (84), Expect = 0.082
 Identities = 70/285 (24%), Positives = 110/285 (38%), Gaps = 47/285 (16%)

Query: 226 GDWSPLETTYPQTACPKSDSEL--EVKPAESLLRSESHMEWTWGGFPESTKV--SKRERS 281
           GDWS    T P+ A P+S+ E   E  P  SL++  S M   W  F E+++V  S R R 
Sbjct: 314 GDWSD---TGPR-ARPESERERDGEQSPNVSLMQRMSDMLSRW--FEEASEVAQSNRGRG 367

Query: 282 DHHPRTATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTS 341
              PR  T     +T   V  S D  +SE                       T M   T 
Sbjct: 368 RSRPRGGTSQSDISTLPTVPSSPDLEVSE-----------------------TAMEVDTP 404

Query: 342 VAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPD 401
             + L+P   ST +S+   +   P  +    P  S P ++     +  G H   Q    +
Sbjct: 405 AEQFLQPSTSST-MSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNN 463

Query: 402 DIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSD 461
           +  L    G    V +L++    +   + +   +D  S      S+ S++   G+ C S+
Sbjct: 464 E-KLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWS------SIASSSRGIGSHCKSE 516

Query: 462 SAMD--LPDVTLSLCGGLSENGEISKEKFMEHIITYHE--FAENP 502
              +  +P  ++    G SE    + E+  E +  Y E   AENP
Sbjct: 517 GQEESFVPQSSVQPPEGDSETK--APEESSEDVTKYQEGVSAENP 559


>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
            sapiens]
          Length = 1782

 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/333 (23%), Positives = 123/333 (36%), Gaps = 53/333 (15%)

Query: 115  FKDIDTPLVKSGGD-ETPSQSSDISHVLETETIFTPS-------SVKKKKRRRKKYKQDS 166
            FK + TP  KS    E  S+ S     +E  T  T         S+KK    R+K + D 
Sbjct: 762  FKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDG 821

Query: 167  KKEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDG 226
            K+E+    A  ED    G + DD                                PLS+ 
Sbjct: 822  KQEQ----APVEDAGPTGANEDDSDVPAVV-------------------------PLSEY 852

Query: 227  DWSPLETTYPQTACPKSDSELEVKPAESLLR--SESHMEWTWGGFPESTKVSK--RERSD 282
            D    E    Q A  KS  + E K A  + +  SES +        + T+ +    ERS 
Sbjct: 853  DAVEREKMEAQQA-QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSP 911

Query: 283  HHPRTATITPSENTHFRVIPSEDNLISE--VEKDASMEDTVCTIVKPKPRALGTQMSDPT 340
                 +   P E      + +E  L++E  +E++   E+   T+ +P P     +     
Sbjct: 912  SWISASVTEPLEQ-----VEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 966

Query: 341  SVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAK--VDSP-SKKKGVHKRSQH 397
            S AEL    + + + +  L A+    A+ AE  +E   A     DSP + ++    +   
Sbjct: 967  SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 1026

Query: 398  QGPDDIYLDDLKGLEPEVAALYFPKSESE-PGS 429
             G  DI   + +  E   A     K ES+ PG+
Sbjct: 1027 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 1059


>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
           sapiens]
          Length = 1684

 Score = 37.0 bits (84), Expect = 0.082
 Identities = 79/333 (23%), Positives = 123/333 (36%), Gaps = 53/333 (15%)

Query: 115 FKDIDTPLVKSGGD-ETPSQSSDISHVLETETIFTPS-------SVKKKKRRRKKYKQDS 166
           FK + TP  KS    E  S+ S     +E  T  T         S+KK    R+K + D 
Sbjct: 664 FKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDG 723

Query: 167 KKEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDG 226
           K+E+    A  ED    G + DD                                PLS+ 
Sbjct: 724 KQEQ----APVEDAGPTGANEDDSDVPAVV-------------------------PLSEY 754

Query: 227 DWSPLETTYPQTACPKSDSELEVKPAESLLR--SESHMEWTWGGFPESTKVSK--RERSD 282
           D    E    Q A  KS  + E K A  + +  SES +        + T+ +    ERS 
Sbjct: 755 DAVEREKMEAQQA-QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSP 813

Query: 283 HHPRTATITPSENTHFRVIPSEDNLISE--VEKDASMEDTVCTIVKPKPRALGTQMSDPT 340
                +   P E      + +E  L++E  +E++   E+   T+ +P P     +     
Sbjct: 814 SWISASVTEPLEQ-----VEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 868

Query: 341 SVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAK--VDSP-SKKKGVHKRSQH 397
           S AEL    + + + +  L A+    A+ AE  +E   A     DSP + ++    +   
Sbjct: 869 SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 928

Query: 398 QGPDDIYLDDLKGLEPEVAALYFPKSESE-PGS 429
            G  DI   + +  E   A     K ES+ PG+
Sbjct: 929 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 961


>gi|145580626 E2F transcription factor 7 [Homo sapiens]
          Length = 911

 Score = 37.0 bits (84), Expect = 0.082
 Identities = 41/187 (21%), Positives = 79/187 (42%), Gaps = 21/187 (11%)

Query: 270 PESTKVSKRE-RSDHHPRTATITPSENTHFRVI----PSEDNLISEVEKDASMEDTVCTI 324
           P S   S+R+ RS   P T  ++ + +   R+     P E++  +   +    ED   ++
Sbjct: 565 PASGSGSERDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSL 624

Query: 325 VKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDS 384
           V PK  +  T ++ P ++      PL+   ++  L A         +A + S  +++  +
Sbjct: 625 VMPKKPSDSTDLASPKTMGNRASIPLKDIHVNGQLPA---AEEISGKATANSLVSSEWGN 681

Query: 385 PSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSP 444
           PS+   V K S+                 E + L +   +S  G   +  +  LSGSQ+P
Sbjct: 682 PSRNTDVEKPSKENES-----------TKEPSLLQYLCVQSPAGLNGF--NVLLSGSQTP 728

Query: 445 QSVGSAA 451
            +VG ++
Sbjct: 729 PTVGPSS 735


>gi|27734897 hypothetical protein LOC203111 [Homo sapiens]
          Length = 374

 Score = 37.0 bits (84), Expect = 0.082
 Identities = 45/225 (20%), Positives = 91/225 (40%), Gaps = 28/225 (12%)

Query: 308 ISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNA 367
           ++  E  ++ E++     +PKP ALG + +   +V     PPL+  ++S+   A+ +   
Sbjct: 20  VTSNEHFSTAEESESCFAQPKPHALGRESTVDGNVQRESRPPLQKLKVSAEPTANGV--K 77

Query: 368 ALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEP 427
            L E P     A   D+  +     K    +G ++       G E +  A    K ++  
Sbjct: 78  PLQEQPLAKDVAPGRDATDQSGSTEKTQPGEGLEESGPPQPGGKE-DAPAAEGKKKDAGA 136

Query: 428 GSRQWPESDTLSGSQSPQSVGSAA----ADSGTECLSDSAMDLPD--------------- 468
           G+    E+++L G+   Q +G  A      +  E  S  A+++ +               
Sbjct: 137 GT----EAESLKGNAEAQPLGPEAKGQPLQAAVEKDSLRAVEVTENPQTAAEMKPLGTTE 192

Query: 469 --VTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNLV 511
             +TL + G L   G + K++    + T  +  E+P +++    V
Sbjct: 193 NVLTLQIAGELQPQGTVGKDEQAPLLETISKENESPEILEGSQFV 237


>gi|23308722 TTK protein kinase [Homo sapiens]
          Length = 857

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 47/217 (21%), Positives = 85/217 (39%), Gaps = 27/217 (12%)

Query: 182 DVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTACP 241
           D+ V      G  +    +  S++    KEPL+         SD   S L  T   T   
Sbjct: 308 DLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLV---------SDEKSSELIITDSITLKN 358

Query: 242 KSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRVI 301
           K++S L       L + E   E+     PES +  K+ +S          P+ +++   I
Sbjct: 359 KTESSL-------LAKLEETKEYQEPEVPESNQ--KQWQSKRKSECINQNPAASSNHWQI 409

Query: 302 PSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDA 361
           P     ++  +K  + E  V ++ K  P    ++  DP S+ +        T  S+ LD 
Sbjct: 410 PELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICK--------TPSSNTLD- 460

Query: 362 DHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQ 398
           D++         ++  PA ++ +P  +    ++ QHQ
Sbjct: 461 DYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQ 497


>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo
           sapiens]
          Length = 2211

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 20/75 (26%), Positives = 35/75 (46%)

Query: 137 ISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDTCDVGVSSDDDKGAQAA 196
           + H++  E   TP    +KK+ + K +Q  KKE   A    +     G   +D+   + +
Sbjct: 898 LRHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEES 957

Query: 197 RGSSNASLKEEECKE 211
             S  +S +EEE +E
Sbjct: 958 SSSEESSSEEEEMEE 972


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 20/66 (30%), Positives = 31/66 (46%)

Query: 575 KEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTS 634
           ++G + APP    P+ +K  AG R  ++ SSS+E   E E      P    P    ++  
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442

Query: 635 YKKSLR 640
            K+S R
Sbjct: 443 AKESPR 448



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 81/374 (21%), Positives = 138/374 (36%), Gaps = 51/374 (13%)

Query: 277 KRERSDHHPRTATITPSENTHFRVIPS-----EDNLISEVEKDASMEDTVC----TIVKP 327
           K  R    P   T   SE      +P+     +  ++S  + D+S EDT      T V+ 
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEG 214

Query: 328 KPRALGTQM-----SDPTSVAELLEP-PLESTQISSMLDADHLPNAALAEAPSESKPAAK 381
           KP     Q+     S   S A    P P +   ++  +    LP A  A+ P E   +++
Sbjct: 215 KPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSE 274

Query: 382 VDSPSKKKG-VHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSG 440
             S S+++     RSQ +  + I L       P         + + PG      S T +G
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKI-LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 333

Query: 441 SQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAE 500
                S  S+   S +E  + +A  L     S  G  S+ G  S               E
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAKALLQAKAS--GKTSQVGAASAPA-----------KE 380

Query: 501 NP--GLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKS--LPKATVESWVKDKMP---K 553
           +P  G    P                 P +   Q  ++      ++ ES  +++ P   K
Sbjct: 381 SPRKGAAPAPP------------GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428

Query: 554 KSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQEL 613
            SG+    R   +  K+ P  ++G + APP    P++++   G +  ++ SSS+E   + 
Sbjct: 429 PSGKAPQVRAASAPAKESP--RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486

Query: 614 EESITVDPIPTEPL 627
           E    ++    +PL
Sbjct: 487 EALAAMNAAQVKPL 500


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 20/66 (30%), Positives = 31/66 (46%)

Query: 575 KEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTS 634
           ++G + APP    P+ +K  AG R  ++ SSS+E   E E      P    P    ++  
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442

Query: 635 YKKSLR 640
            K+S R
Sbjct: 443 AKESPR 448



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 81/374 (21%), Positives = 138/374 (36%), Gaps = 51/374 (13%)

Query: 277 KRERSDHHPRTATITPSENTHFRVIPS-----EDNLISEVEKDASMEDTVC----TIVKP 327
           K  R    P   T   SE      +P+     +  ++S  + D+S EDT      T V+ 
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEG 214

Query: 328 KPRALGTQM-----SDPTSVAELLEP-PLESTQISSMLDADHLPNAALAEAPSESKPAAK 381
           KP     Q+     S   S A    P P +   ++  +    LP A  A+ P E   +++
Sbjct: 215 KPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSE 274

Query: 382 VDSPSKKKG-VHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSG 440
             S S+++     RSQ +  + I L       P         + + PG      S T +G
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKI-LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 333

Query: 441 SQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAE 500
                S  S+   S +E  + +A  L     S  G  S+ G  S               E
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAKALLQAKAS--GKTSQVGAASAPA-----------KE 380

Query: 501 NP--GLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKS--LPKATVESWVKDKMP---K 553
           +P  G    P                 P +   Q  ++      ++ ES  +++ P   K
Sbjct: 381 SPRKGAAPAPP------------GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428

Query: 554 KSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQEL 613
            SG+    R   +  K+ P  ++G + APP    P++++   G +  ++ SSS+E   + 
Sbjct: 429 PSGKAPQVRAASAPAKESP--RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486

Query: 614 EESITVDPIPTEPL 627
           E    ++    +PL
Sbjct: 487 EALAAMNAAQVKPL 500


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 20/66 (30%), Positives = 31/66 (46%)

Query: 575 KEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTS 634
           ++G + APP    P+ +K  AG R  ++ SSS+E   E E      P    P    ++  
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442

Query: 635 YKKSLR 640
            K+S R
Sbjct: 443 AKESPR 448



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 81/374 (21%), Positives = 138/374 (36%), Gaps = 51/374 (13%)

Query: 277 KRERSDHHPRTATITPSENTHFRVIPS-----EDNLISEVEKDASMEDTVC----TIVKP 327
           K  R    P   T   SE      +P+     +  ++S  + D+S EDT      T V+ 
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEG 214

Query: 328 KPRALGTQM-----SDPTSVAELLEP-PLESTQISSMLDADHLPNAALAEAPSESKPAAK 381
           KP     Q+     S   S A    P P +   ++  +    LP A  A+ P E   +++
Sbjct: 215 KPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSE 274

Query: 382 VDSPSKKKG-VHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSG 440
             S S+++     RSQ +  + I L       P         + + PG      S T +G
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKI-LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 333

Query: 441 SQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAE 500
                S  S+   S +E  + +A  L     S  G  S+ G  S               E
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAKALLQAKAS--GKTSQVGAASAPA-----------KE 380

Query: 501 NP--GLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKS--LPKATVESWVKDKMP---K 553
           +P  G    P                 P +   Q  ++      ++ ES  +++ P   K
Sbjct: 381 SPRKGAAPAPP------------GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428

Query: 554 KSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQEL 613
            SG+    R   +  K+ P  ++G + APP    P++++   G +  ++ SSS+E   + 
Sbjct: 429 PSGKAPQVRAASAPAKESP--RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486

Query: 614 EESITVDPIPTEPL 627
           E    ++    +PL
Sbjct: 487 EALAAMNAAQVKPL 500


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 20/66 (30%), Positives = 31/66 (46%)

Query: 575 KEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTS 634
           ++G + APP    P+ +K  AG R  ++ SSS+E   E E      P    P    ++  
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442

Query: 635 YKKSLR 640
            K+S R
Sbjct: 443 AKESPR 448



 Score = 35.0 bits (79), Expect = 0.31
 Identities = 81/374 (21%), Positives = 138/374 (36%), Gaps = 51/374 (13%)

Query: 277 KRERSDHHPRTATITPSENTHFRVIPS-----EDNLISEVEKDASMEDTVC----TIVKP 327
           K  R    P   T   SE      +P+     +  ++S  + D+S EDT      T V+ 
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEG 214

Query: 328 KPRALGTQM-----SDPTSVAELLEP-PLESTQISSMLDADHLPNAALAEAPSESKPAAK 381
           KP     Q+     S   S A    P P +   ++  +    LP A  A+ P E   +++
Sbjct: 215 KPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSE 274

Query: 382 VDSPSKKKG-VHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSG 440
             S S+++     RSQ +  + I L       P         + + PG      S T +G
Sbjct: 275 EGSESEEEAPAGTRSQVKASEKI-LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 333

Query: 441 SQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAE 500
                S  S+   S +E  + +A  L     S  G  S+ G  S               E
Sbjct: 334 KPEEDSESSSEESSDSEEETPAAKALLQAKAS--GKTSQVGAASAPA-----------KE 380

Query: 501 NP--GLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKS--LPKATVESWVKDKMP---K 553
           +P  G    P                 P +   Q  ++      ++ ES  +++ P   K
Sbjct: 381 SPRKGAAPAPP------------GKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428

Query: 554 KSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQEL 613
            SG+    R   +  K+ P  ++G + APP    P++++   G +  ++ SSS+E   + 
Sbjct: 429 PSGKAPQVRAASAPAKESP--RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486

Query: 614 EESITVDPIPTEPL 627
           E    ++    +PL
Sbjct: 487 EALAAMNAAQVKPL 500


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 43/179 (24%), Positives = 68/179 (37%), Gaps = 13/179 (7%)

Query: 272  STKVSKRERSDHHPRTATITPSENTHFRVIPS----EDNLISEVEKDASMEDTVCTIVKP 327
            S KV ++E  D        T S     R+ PS    E++  SE E+D  M DT C + K 
Sbjct: 961  SFKVKRKEPPD--------TTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKR 1012

Query: 328  KPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPSK 387
             P+ +G +   P    EL     E  + S   + +       AE   E +     DS  +
Sbjct: 1013 DPKGVGVRRR-PARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDR 1071

Query: 388  KKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQS 446
             +  +        +    D+    E E  ++   K+E+   S     S+  S S+S  S
Sbjct: 1072 DESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPS 1130


>gi|33356179 transcription termination factor, RNA polymerase I
           [Homo sapiens]
          Length = 905

 Score = 35.8 bits (81), Expect = 0.18
 Identities = 54/236 (22%), Positives = 94/236 (39%), Gaps = 39/236 (16%)

Query: 142 ETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSN 201
           ET  +  P+  KK K+++KK     + E  A    ++   +VG    + + A    G + 
Sbjct: 262 ETPQLLGPTHKKKSKKKKKKKSNHQEFEALAMPEGSQVGSEVGADMQESRPAVGLHGETA 321

Query: 202 A----SLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTACPKSDSELEVKPAESLLR 257
                + K +  K+    +  +   ++  +   LE+ YP+ +  +  SE+      + L+
Sbjct: 322 GIPAPAYKNKSKKKKKKSNHQEFEAVAMPE--SLESAYPEGS--QVGSEVGTVEGSTALK 377

Query: 258 SESHMEWTWGGFPE--STKVSKRERSDHHPRTATIT------PSENTHFRVIPSEDNLIS 309
                     GF E  STK   ++R     + A ++      PS+N       SE  L  
Sbjct: 378 ----------GFKESNSTKKKSKKRKLTSVKRARVSGDDFSVPSKN-------SESTLFD 420

Query: 310 EVEKDASMEDTVCTIVKPKPRALGTQ---MSDPTSVAELLEPPLESTQISSMLDAD 362
            VE D +M +     VK +PR   TQ    S     A  LEP  E   + +  D++
Sbjct: 421 SVEGDGAMMEEG---VKSRPRQKKTQACLASKHVQEAPRLEPANEEHNVETAEDSE 473


>gi|168229156 NFKB activating protein [Homo sapiens]
          Length = 415

 Score = 35.8 bits (81), Expect = 0.18
 Identities = 20/84 (23%), Positives = 39/84 (46%)

Query: 128 DETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDTCDVGVSS 187
           DE P +S+  +   E E     S  K++ ++R+K K   +K ++ +  +  D+     SS
Sbjct: 165 DEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSS 224

Query: 188 DDDKGAQAARGSSNASLKEEECKE 211
           D+D   +A +       K+   K+
Sbjct: 225 DEDNKRRAKKAKKKEKKKKHRSKK 248


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,335,337
Number of Sequences: 37866
Number of extensions: 1881510
Number of successful extensions: 7695
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 7218
Number of HSP's gapped (non-prelim): 567
length of query: 896
length of database: 18,247,518
effective HSP length: 111
effective length of query: 785
effective length of database: 14,044,392
effective search space: 11024847720
effective search space used: 11024847720
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.