Search of human proteins with 7661974

Search of human proteins with 7661974

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7661974 maternal embryonic leucine zipper kinase [Homo
sapiens]
         (651 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]   1332   0.0  
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   289   6e-78
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   284   2e-76
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   281   1e-75
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   278   9e-75
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   273   3e-73
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   273   5e-73
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   271   1e-72
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   255   1e-67
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   252   7e-67
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   251   1e-66
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   249   6e-66
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   249   6e-66
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   245   1e-64
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   244   1e-64
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        240   3e-63
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               234   2e-61
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              229   8e-60
gi|116256471 SNF1-like kinase [Homo sapiens]                          228   1e-59
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         226   5e-59
gi|156105707 SNF related kinase [Homo sapiens]                        220   4e-57
gi|156105705 SNF related kinase [Homo sapiens]                        220   4e-57
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               213   4e-55
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       200   3e-51
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   197   3e-50
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   197   3e-50
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           197   3e-50
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   197   3e-50
gi|27901803 protein serine kinase H1 [Homo sapiens]                   183   5e-46
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   181   2e-45

>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score = 1332 bits (3447), Expect = 0.0
 Identities = 651/651 (100%), Positives = 651/651 (100%)

Query: 1   MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA 60
           MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
Sbjct: 1   MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA 60

Query: 61  LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV 120
           LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
Sbjct: 61  LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV 120

Query: 121 AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI 180
           AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
Sbjct: 121 AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI 180

Query: 181 QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL 240
           QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
Sbjct: 181 QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL 240

Query: 241 QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT 300
           QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
Sbjct: 241 QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT 300

Query: 301 MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV 360
           MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
Sbjct: 301 MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV 360

Query: 361 TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL 420
           TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
Sbjct: 361 TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL 420

Query: 421 KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI 480
           KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
Sbjct: 421 KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI 480

Query: 481 KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV 540
           KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
Sbjct: 481 KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV 540

Query: 541 LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT 600
           LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
Sbjct: 541 LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT 600

Query: 601 QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651
           QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Sbjct: 601 QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  289 bits (739), Expect = 6e-78
 Identities = 211/670 (31%), Positives = 333/670 (49%), Gaps = 41/670 (6%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG  VAIKI+DK  L  + L ++  E+  +K L H +I
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++++EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   G K   L T CGS  YAAPEL QGK Y G 
Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGKKYDGP 232

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   WI   +          P + + D    ++ V    +++ +++ +S  
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKM 352

Query: 309 QYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQA-----SATPFTDIKSNNWS------L 357
           +YD +TATYLLL  K +  +P    L++ S GQ+       + F+  K   +S      +
Sbjct: 353 KYDEITATYLLLGRKSSEVRP-SSDLNN-STGQSPHHKVQRSVFSSQKQRRYSDHAGPAI 410

Query: 358 EDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPA 417
             V A  K       D D  ED +S+     R S  +    +     S  L  A     A
Sbjct: 411 PSVVAYPKRSQTSTADSDLKEDGISS-----RKSSGSAVGGKGIAPASPMLGNASNPNKA 465

Query: 418 NKLKNKENVYTPKS-----AVKNEEYFMFPEPKTPVNKN--QHKREILTTPNRYTTPSKA 470
           +  + K++   P S      +     ++  E  T    +  Q+ +E  T P++ T  +  
Sbjct: 466 DIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAST 525

Query: 471 RNQCLKETPIKIPVNSTGTDKLMTGVISP-ERRC-------RSVELDLNQAHMEETPKRK 522
            +     TP +I     GT    T    P ERR         S  L      + +T  R 
Sbjct: 526 HSISSAATPDRIRF-PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 584

Query: 523 GAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSIL 582
              +F  L   L +   V    K +      PR L+  +++ TT  ++P  ++ EI  +L
Sbjct: 585 STNLFSKLTSKLTRSRNVSAEQKDENKEAK-PRSLRFTWSMKTTSSMDPGDMMREIRKVL 643

Query: 583 PKKHVDFVQK-GYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRL 641
              + D+ Q+  + L C       +  +Q+E+EVC+L +  + G+R +R+ G +  +K +
Sbjct: 644 DANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNI 703

Query: 642 VEDILSSCKV 651
              I +  K+
Sbjct: 704 ASKIANELKL 713


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  284 bits (727), Expect = 2e-76
 Identities = 208/685 (30%), Positives = 330/685 (48%), Gaps = 55/685 (8%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG  VAIKI+DK  L  + L ++  E+  +K L H +I
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++++EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   G K   L T CGS  YAAPEL QGK Y G 
Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGKKYDGP 232

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   WI   +          P + + D    ++ V    +++ +++ +S  
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKM 352

Query: 309 QYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNW------------- 355
           +YD +TATY LLL +K+         SS +   A   P +D+ ++               
Sbjct: 353 KYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFS 411

Query: 356 -------------SLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNG 402
                        ++  V A  K       D D  ED +S+     R S  +    +   
Sbjct: 412 SQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISS-----RKSSGSAVGGKGIA 466

Query: 403 VESKSLTPALCRTPANKLKNKENVYTPKS-----AVKNEEYFMFPEPKTPVNKN--QHKR 455
             S  L  A     A+  + K++   P S      +     ++  E  T    +  Q+ +
Sbjct: 467 PASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGK 526

Query: 456 EILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISP-ERRC-------RSVE 507
           E  T P++ T  +   +     TP +I     GT    T    P ERR         S  
Sbjct: 527 ENSTIPDQRTPVASTHSISSAATPDRIRF-PRGTASRSTFHGQPRERRTATYNGPPASPS 585

Query: 508 LDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTR 567
           L      + +T  R    +F  L   L +   V    K +      PR L+  +++ TT 
Sbjct: 586 LSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAK-PRSLRFTWSMKTTS 644

Query: 568 LVNPDQLLNEIMSILPKKHVDFVQK-GYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGI 626
            ++P  ++ EI  +L   + D+ Q+  + L C       +  +Q+E+EVC+L +  + G+
Sbjct: 645 SMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGV 704

Query: 627 RRQRLKGDAWVYKRLVEDILSSCKV 651
           R +R+ G +  +K +   I +  K+
Sbjct: 705 RFKRISGTSIAFKNIASKIANELKL 729


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  281 bits (719), Expect = 1e-75
 Identities = 212/699 (30%), Positives = 338/699 (48%), Gaps = 68/699 (9%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG  VAIKI+DK  L  + L ++  E+  +K L H +I
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++++EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   G K   L T CGS  YAAPEL QGK Y G 
Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGKKYDGP 232

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   WI   +          P + + D    ++ V    +++ +++ +S  
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKM 352

Query: 309 QYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNW------------- 355
           +YD +TATY LLL +K+         SS +   A   P +D+ ++               
Sbjct: 353 KYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFS 411

Query: 356 -------------SLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNG 402
                        ++  V A  K       D D  ED +S+     R S  +    +   
Sbjct: 412 SQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISS-----RKSSGSAVGGKGIA 466

Query: 403 VESKSLTPALCRTPANKLKNKENVYTPKS-----AVKNEEYFMFPEPKTPVNKN--QHKR 455
             S  L  A     A+  + K++   P S      +     ++  E  T    +  Q+ +
Sbjct: 467 PASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGK 526

Query: 456 EILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISP-ERRC-------RSVE 507
           E  T P++ T  +   +     TP +I     GT    T    P ERR         S  
Sbjct: 527 ENSTIPDQRTPVASTHSISSAATPDRIRF-PRGTASRSTFHGQPRERRTATYNGPPASPS 585

Query: 508 LDLNQAHMEETPKRKGAKVFGSLERGLDKVI-TVLTRSKR-KGSARD------------G 553
           L      + +T  R    +F  L   L + + T   R+ R +GS+R+             
Sbjct: 586 LSHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKEAK 645

Query: 554 PRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQK-GYTLKCQTQSDFGKVTMQFE 612
           PR L+  +++ TT  ++P  ++ EI  +L   + D+ Q+  + L C       +  +Q+E
Sbjct: 646 PRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWE 705

Query: 613 LEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651
           +EVC+L +  + G+R +R+ G +  +K +   I +  K+
Sbjct: 706 MEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 744


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  278 bits (712), Expect = 9e-75
 Identities = 212/708 (29%), Positives = 339/708 (47%), Gaps = 77/708 (10%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG  VAIKI+DK  L  + L ++  E+  +K L H +I
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++++EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   G K   L T CGS  YAAPEL QGK Y G 
Sbjct: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGKKYDGP 232

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   WI   +          P + + D    ++ V    +++ +++ +S  
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKM 352

Query: 309 QYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNW------------- 355
           +YD +TATY LLL +K+         SS +   A   P +D+ ++               
Sbjct: 353 KYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFS 411

Query: 356 -------------SLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNG 402
                        ++  V A  K       D D  ED +S+     R S  +    +   
Sbjct: 412 SQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISS-----RKSSGSAVGGKGIA 466

Query: 403 VESKSLTPALCRTPANKLKNKENVYTPKS-----AVKNEEYFMFPEPKTPVNKN--QHKR 455
             S  L  A     A+  + K++   P S      +     ++  E  T    +  Q+ +
Sbjct: 467 PASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGK 526

Query: 456 EILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISP-ERRC-------RSVE 507
           E  T P++ T  +   +     TP +I     GT    T    P ERR         S  
Sbjct: 527 ENSTIPDQRTPVASTHSISSAATPDRIRF-PRGTASRSTFHGQPRERRTATYNGPPASPS 585

Query: 508 LDLNQAHMEETPKRKGAKVFGSLE----------RGLDKVITVLTRSKR-KGSARD---- 552
           L      + +T  R    +F  L           R + ++ T   R+ R +GS+R+    
Sbjct: 586 LSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAE 645

Query: 553 --------GPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQK-GYTLKCQTQSD 603
                    PR L+  +++ TT  ++P  ++ EI  +L   + D+ Q+  + L C     
Sbjct: 646 QKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDG 705

Query: 604 FGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651
             +  +Q+E+EVC+L +  + G+R +R+ G +  +K +   I +  K+
Sbjct: 706 HAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  273 bits (699), Expect = 3e-73
 Identities = 207/686 (30%), Positives = 334/686 (48%), Gaps = 64/686 (9%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 172

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 173 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 229

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 349

Query: 309 QYDHLTATYLLLLAKKA--RGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKN 366
           +Y+ + ATYLLL  K +   G  + L+    +    S+ P    K        V+A+ K 
Sbjct: 350 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQ----RSVSANPKQ 405

Query: 367 YVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENV 426
                        D + G A P ++ ++K  T+SN  E+K   P   R    K  +   V
Sbjct: 406 RRF---------SDQAAGPAIPTSNSYSKK-TQSNNAENK--RPEEDRESGRKASSTAKV 453

Query: 427 -YTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTT-PSKARNQCLKETPIKIPV 484
             +P   ++ ++    P   + ++ + ++        R +   +  +N      P ++PV
Sbjct: 454 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPV 513

Query: 485 NSTGTDKLMTGVISPER----------------RCRSVELDLNQAH-------MEETPKR 521
            S     + +   +P+R                + R V    N  +          +  R
Sbjct: 514 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGR 573

Query: 522 KGA--KVFGS-----LERGLD-------KVITVLTRSKRKGSARDG-PRRLKLHYNVTTT 566
           +GA   +F       + R L         V+      K K   R+  PR L+  +++ TT
Sbjct: 574 RGASGSIFSKFTSKFVRRNLSFRFARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTT 633

Query: 567 RLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVG 625
             + P++++ EI  +L        + + Y L C   +   +  +Q+E+EVC+L +  + G
Sbjct: 634 SSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNG 693

Query: 626 IRRQRLKGDAWVYKRLVEDILSSCKV 651
           +R +R+ G +  +K +   I +  K+
Sbjct: 694 VRFKRISGTSMAFKNIASKIANELKL 719


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  273 bits (697), Expect = 5e-73
 Identities = 204/677 (30%), Positives = 330/677 (48%), Gaps = 56/677 (8%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 172

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 173 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 229

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 349

Query: 309 QYDHLTATYLLLLAKKA--RGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKN 366
           +Y+ + ATYLLL  K +   G  + L+    +    S+ P    K        V+A+ K 
Sbjct: 350 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQ----RSVSANPKQ 405

Query: 367 YVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENV 426
                            G A P ++ ++K  T+SN  E+K   P   R    K  +   V
Sbjct: 406 R----------RFSDQAGPAIPTSNSYSKK-TQSNNAENK--RPEEDRESGRKASSTAKV 452

Query: 427 -YTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTT-PSKARNQCLKETPIKIPV 484
             +P   ++ ++    P   + ++ + ++        R +   +  +N      P ++PV
Sbjct: 453 PASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPV 512

Query: 485 NSTGTDKLMTGVISPER----------------RCRSVELDLNQAH-------MEETPKR 521
            S     + +   +P+R                + R V    N  +          +  R
Sbjct: 513 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGR 572

Query: 522 KGA--KVFGSLERGLDK---VITVLTRSKRKGSARDG-PRRLKLHYNVTTTRLVNPDQLL 575
           +GA   +F        +   V+      K K   R+  PR L+  +++ TT  + P++++
Sbjct: 573 RGASGSIFSKFTSKFVRRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMM 632

Query: 576 NEIMSILPKKHVDF-VQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGD 634
            EI  +L        + + Y L C   +   +  +Q+E+EVC+L +  + G+R +R+ G 
Sbjct: 633 REIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGT 692

Query: 635 AWVYKRLVEDILSSCKV 651
           +  +K +   I +  K+
Sbjct: 693 SMAFKNIASKIANELKL 709


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  271 bits (693), Expect = 1e-72
 Identities = 205/688 (29%), Positives = 333/688 (48%), Gaps = 63/688 (9%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 172

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 173 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 229

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 349

Query: 309 QYDHLTATYLLLLAKKA--RGKPVRLR------LSSFSCGQASATPFTDIKSN------- 353
           +Y+ + ATYLLL  K +   G  + L+      L++ S    S      + +N       
Sbjct: 350 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFS 409

Query: 354 ---NWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTP 410
                ++    +  K   +   +    E+D  +G     T++     +   G+E K  TP
Sbjct: 410 DQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA--SPLPGLERKKTTP 467

Query: 411 -----ALCRTPANKLKNK---ENVYTPKSAVKNEEYFMFPEPKTPVNKNQHK-REILTTP 461
                ++  T  N+ +N    E     +++++N +    P+     + + H        P
Sbjct: 468 TPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAP 527

Query: 462 NRYTTP-----------------SKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCR 504
           +R   P                    +N     TP     +S G  +  +G I  +   +
Sbjct: 528 DRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGR-RGASGSIFSKFTSK 586

Query: 505 SVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVT 564
            V  +LN+   ++  +     V GS   G DK       +K        PR L+  +++ 
Sbjct: 587 FVRRNLNEPESKDRVETLRPHVVGS--GGNDKEKEEFREAK--------PRSLRFTWSMK 636

Query: 565 TTRLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDV 623
           TT  + P++++ EI  +L        + + Y L C   +   +  +Q+E+EVC+L +  +
Sbjct: 637 TTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSL 696

Query: 624 VGIRRQRLKGDAWVYKRLVEDILSSCKV 651
            G+R +R+ G +  +K +   I +  K+
Sbjct: 697 NGVRFKRISGTSMAFKNIASKIANELKL 724


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  255 bits (651), Expect = 1e-67
 Identities = 139/318 (43%), Positives = 195/318 (61%), Gaps = 10/318 (3%)

Query: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQ 67
           +Y L +T+G G F KVK+  H LTG  VA+KI+++  + S   + +I+ EI+ LK  RH 
Sbjct: 26  HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 85

Query: 68  HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 127
           HI +LY V+ T + IFMV+EY  GGELFDYI    RL E+E+R +F+QI+S V Y H   
Sbjct: 86  HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 145

Query: 128 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLG 187
             HRDLKPEN+L D +   K+ DFGL       +   L+T CGS  YAAPE+I G+ Y G
Sbjct: 146 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLYAG 203

Query: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVD 247
            E D+WS G++LY L+CG LPFDDD+V  L+KKI  G +  P++L+PS I LL+ MLQVD
Sbjct: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 263

Query: 248 PKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTELSVHHR-NNRQTMED 303
           P KR ++K++  H W  QD   Y +P +    +  I  DD+ + E+      +  + +  
Sbjct: 264 PMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMI--DDEALKEVCEKFECSEEEVLSC 321

Query: 304 LISLWQYDHLTATYLLLL 321
           L +    D L   Y L++
Sbjct: 322 LYNRNHQDPLAVAYHLII 339


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  252 bits (644), Expect = 7e-67
 Identities = 162/437 (37%), Positives = 237/437 (54%), Gaps = 33/437 (7%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 53  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 172

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 173 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 229

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 349

Query: 309 QYDHLTATYLLLLAKKA--RGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKN 366
           +Y+ + ATYLLL  K +   G  + L+    +    S+ P    K        V+A+ K 
Sbjct: 350 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQ----RSVSANPKQ 405

Query: 367 YVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESK------------SLTPALCR 414
                        D + G A P ++ ++K  T+SN  E+K            S T  +  
Sbjct: 406 RRF---------SDQAAGPAIPTSNSYSKK-TQSNNAENKRPEEDRESGRKASSTAKVPA 455

Query: 415 TPANKLKNKENVYTPKS 431
           +P   L+ K+   TP +
Sbjct: 456 SPLPGLERKKTTPTPST 472



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 28/109 (25%), Positives = 57/109 (52%), Gaps = 2/109 (1%)

Query: 545 KRKGSARDG-PRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQS 602
           K K   R+  PR L+  +++ TT  + P++++ EI  +L        + + Y L C   +
Sbjct: 680 KEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGT 739

Query: 603 DFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651
              +  +Q+E+EVC+L +  + G+R +R+ G +  +K +   I +  K+
Sbjct: 740 PGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  251 bits (642), Expect = 1e-66
 Identities = 138/323 (42%), Positives = 197/323 (60%), Gaps = 13/323 (4%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L  TIG G FAKVKLA HILTG  VAIKI+DK  L  S L ++  E+  +K L H +I
Sbjct: 59  YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 118

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++V+EY   GE+FDY++S  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 119 VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV 178

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   G+K   L T CGS  YAAPEL QGK Y G 
Sbjct: 179 HRDLKAENLLLDAEANIKIADFGFSNEFTLGSK---LDTFCGSPPYAAPELFQGKKYDGP 235

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E D+WS+G++LY L+ G LPFD  N+  L ++++RGKY VP ++S     +L++ L ++P
Sbjct: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDC----VTELSVHHRNNRQTMEDL 304
            KR +++ ++   WI    N   E +   P+   ++D       E+ V     R+ +++ 
Sbjct: 296 AKRCTLEQIMKDKWI----NIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKES 351

Query: 305 ISLWQYDHLTATYLLLLAKKARG 327
           ++  +Y+ +TATYLLL  K   G
Sbjct: 352 LTSQKYNEVTATYLLLGRKTEEG 374


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  249 bits (636), Expect = 6e-66
 Identities = 161/437 (36%), Positives = 235/437 (53%), Gaps = 34/437 (7%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA HILTG+ VA+KI+DK  L S  L ++  E+  +K L H +I
Sbjct: 20  YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 79

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 80  VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 139

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 140 HRDLKAENLLLDADMNIKIADFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKYDGP 196

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308
            KR +++ ++   W+   +          P     D   TEL V     R+ ++D +   
Sbjct: 257 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQ 316

Query: 309 QYDHLTATYLLLLAKKA--RGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKN 366
           +Y+ + ATYLLL  K +   G  + L+    +    S+ P    K        V+A+ K 
Sbjct: 317 RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQ----RSVSANPKQ 372

Query: 367 YVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESK------------SLTPALCR 414
                            G A P ++ ++K  T+SN  E+K            S T  +  
Sbjct: 373 R----------RFSDQAGPAIPTSNSYSKK-TQSNNAENKRPEEDRESGRKASSTAKVPA 421

Query: 415 TPANKLKNKENVYTPKS 431
           +P   L+ K+   TP +
Sbjct: 422 SPLPGLERKKTTPTPST 438



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 28/109 (25%), Positives = 57/109 (52%), Gaps = 2/109 (1%)

Query: 545 KRKGSARDG-PRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDF-VQKGYTLKCQTQS 602
           K K   R+  PR L+  +++ TT  + P++++ EI  +L        + + Y L C   +
Sbjct: 637 KEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGT 696

Query: 603 DFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651
              +  +Q+E+EVC+L +  + G+R +R+ G +  +K +   I +  K+
Sbjct: 697 PGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 745


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  249 bits (636), Expect = 6e-66
 Identities = 140/318 (44%), Positives = 191/318 (60%), Gaps = 10/318 (3%)

Query: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQ 67
           +Y L +T+G G F KVK+  H LTG  VA+KI+++  + S   + +IK EI+ LK  RH 
Sbjct: 15  HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74

Query: 68  HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 127
           HI +LY V+ T    FMV+EY  GGELFDYI    R+ E E R +F+QI+SAV Y H   
Sbjct: 75  HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134

Query: 128 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLG 187
             HRDLKPEN+L D +   K+ DFGL       +   L+T CGS  YAAPE+I G+ Y G
Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLYAG 192

Query: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVD 247
            E D+WS G++LY L+CG LPFDD++V  L+KKI  G + +P++L+ S   LL  MLQVD
Sbjct: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252

Query: 248 PKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTELSVHHR-NNRQTMED 303
           P KR ++K++  H W  QD   Y +P E  S +  + +DD+ V E+         + M  
Sbjct: 253 PLKRATIKDIREHEWFKQDLPSYLFP-EDPSYDANV-IDDEAVKEVCEKFECTESEVMNS 310

Query: 304 LISLWQYDHLTATYLLLL 321
           L S    D L   Y L++
Sbjct: 311 LYSGDPQDQLAVAYHLII 328


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  245 bits (625), Expect = 1e-64
 Identities = 139/333 (41%), Positives = 195/333 (58%), Gaps = 25/333 (7%)

Query: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQ 67
           +Y L +T+G G F KVK+  H LTG  VA+KI+++  + S   + +I+ EI+ LK  RH 
Sbjct: 26  HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 85

Query: 68  HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR---------------LSEEETRVV 112
           HI +LY V+ T + IFMV+EY  GGELFDYI    R               L E+E+R +
Sbjct: 86  HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRL 145

Query: 113 FRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSL 172
           F+QI+S V Y H     HRDLKPEN+L D +   K+ DFGL       +   L+T CGS 
Sbjct: 146 FQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSP 203

Query: 173 AYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWL 232
            YAAPE+I G+ Y G E D+WS G++LY L+CG LPFDDD+V  L+KKI  G +  P++L
Sbjct: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 263

Query: 233 SPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTE 289
           +PS I LL+ MLQVDP KR ++K++  H W  QD   Y +P +    +  I  DD+ + E
Sbjct: 264 NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMI--DDEALKE 321

Query: 290 LSVHHR-NNRQTMEDLISLWQYDHLTATYLLLL 321
           +      +  + +  L +    D L   Y L++
Sbjct: 322 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLII 354


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  244 bits (624), Expect = 1e-64
 Identities = 135/316 (42%), Positives = 193/316 (61%), Gaps = 13/316 (4%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L +TIG G FAKVKLA H+LTG  VA+KI+DK  L  + L ++  E+  +K L H +I
Sbjct: 60  YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V+ET   +++V+EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
           HRDLK ENLL D    +K+ DFG   +   GNK   L T CGS  YAAPEL QGK Y G 
Sbjct: 180 HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK---LDTFCGSPPYAAPELFQGKKYDGP 236

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL+++L ++P
Sbjct: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDC----VTELSVHHRNNRQTMEDL 304
            KR S++ ++   W+    N   E +   P+   D D       ++ V     R  + D 
Sbjct: 297 IKRGSLEQIMKDRWM----NVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDA 352

Query: 305 ISLWQYDHLTATYLLL 320
           +   +YD + ATY+LL
Sbjct: 353 LINQKYDEVMATYILL 368



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 30/110 (27%), Positives = 59/110 (53%), Gaps = 2/110 (1%)

Query: 543 RSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQS 602
           R K +G     PR L+  +++ TT  ++P+ ++ EI  +L   + D+ QK   L      
Sbjct: 687 RDKEEGKDSK-PRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHG 745

Query: 603 DFGKVTM-QFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651
           D  + ++ Q+E+EVC+L +  + G+R +R+ G +  +K +   I +  K+
Sbjct: 746 DARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  240 bits (612), Expect = 3e-63
 Identities = 133/333 (39%), Positives = 197/333 (59%), Gaps = 13/333 (3%)

Query: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQH 68
           YYE+  TIG G FA VK A H++T   VAIKI+DK  L  + L +I  E++ +K L H H
Sbjct: 7   YYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPH 66

Query: 69  ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
           I +LY V+ET   I++V EY  GGE+FD++++  R++E+E R  F+QIV+AV + H +  
Sbjct: 67  IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126

Query: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
            HRDLK ENLL D    +K+ DFG            L+T CGS  YAAPEL +GK Y G 
Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           + D+WS+G++LYVL+CG LPFD   +  L  +++ GK+ +P ++S     L++ ML +DP
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244

Query: 249 KKRISMKNLLNHPWIM---QDYNYP------VEWQSKNPFIHLDDDCVTELSVHHRNNRQ 299
            KR+SM+ +  H W+     D N+        + + +     L++D +  +     +  Q
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304

Query: 300 TMEDLISLWQYDHLTATYLLLLAKKARGKPVRL 332
           T++ L S   YDH +A Y LL  +  R K +RL
Sbjct: 305 TLQSLRS-DAYDHYSAIYSLLCDRHKRHKTLRL 336


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  234 bits (597), Expect = 2e-61
 Identities = 114/261 (43%), Positives = 172/261 (65%), Gaps = 3/261 (1%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L +T+G G    VKL  H +TG+ VAIKI+++  L  S L +++ EI  LK + H H+
Sbjct: 34  YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 93

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V E    +++VLE+  GGELFDY++ + RL+ +E R  FRQIVSA+ + HS    
Sbjct: 94  LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSIC 153

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSE 189
           HRDLKPENLL DE + +++ DFG+ +   G  D  L+T CGS  YA PE+I+G+ Y G  
Sbjct: 154 HRDLKPENLLLDEKNNIRIADFGMASLQVG--DSLLETSCGSPHYACPEVIKGEKYDGRR 211

Query: 190 ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPK 249
           AD+WS G++L+ L+ G LPFDDDN+  L +K+ RG + +P ++ P    LL+ M++V+P+
Sbjct: 212 ADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPE 271

Query: 250 KRISMKNLLNHPWIMQDYNYP 270
           KR+S++ +  HPW +   + P
Sbjct: 272 KRLSLEQIQKHPWYLGGKHEP 292


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  229 bits (583), Expect = 8e-60
 Identities = 127/330 (38%), Positives = 199/330 (60%), Gaps = 19/330 (5%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
           Y L +T+G G    VKL  H +T + VAIKI+++  L  S L +++ EI  LK + H H+
Sbjct: 19  YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 78

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            +L+ V E    +++VLE+  GGELFDY++ + RL+ +E R  FRQI+SA+ + HS    
Sbjct: 79  LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 138

Query: 130 HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSE 189
           HRDLKPENLL DE + +++ DFG+ +   G  D  L+T CGS  YA PE+I+G+ Y G +
Sbjct: 139 HRDLKPENLLLDEKNNIRIADFGMASLQVG--DSLLETSCGSPHYACPEVIRGEKYDGRK 196

Query: 190 ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPK 249
           ADVWS G++L+ L+ G LPFDDDN+  L +K+ RG + +P ++ P    LL+ M++VD  
Sbjct: 197 ADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAA 256

Query: 250 KRISMKNLLNHPWIMQDYNYP---------VEWQSKNPFIHLDDDCVTELSVH----HRN 296
           +R++++++  H W +   N P         V+ +S      +D D +   S+H     R+
Sbjct: 257 RRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLD--SMHSLGCFRD 314

Query: 297 NRQTMEDLISLWQYDHLTATYLLLLAKKAR 326
             + ++DL+S  + +     Y LLL +K R
Sbjct: 315 RNKLLQDLLS-EEENQEKMIYFLLLDRKER 343


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  228 bits (581), Expect = 1e-59
 Identities = 128/322 (39%), Positives = 190/322 (59%), Gaps = 11/322 (3%)

Query: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL-GSDLPRIKTEIEALKNLRHQH 68
           +Y++  T+G G FA VKLA H +T   VAIKI+DK  L  S+L +I  E++ +K L H H
Sbjct: 26  FYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPH 85

Query: 69  ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
           I +LY V+ET + +++V E+   GE+FDY+ S   LSE E R  F QI+SAV Y H    
Sbjct: 86  IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145

Query: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
            HRDLK ENLL D    +KL DFG     K  +   L T CGS  YAAPE+ +GK Y G 
Sbjct: 146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEP--LSTWCGSPPYAAPEVFEGKEYEGP 203

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           + D+WS+G++LYVL+CG LPFD  N+  L ++++ G++ +P ++S     L+++ML VDP
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263

Query: 249 KKRISMKNLLNHPWIMQDYNYP----VEWQSKNPFIHLDDDCVTELSVHHR---NNRQTM 301
            +RI++  +  H W+  +   P      + + +   +L D     L +      + ++T+
Sbjct: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTV 323

Query: 302 EDLISLWQYDHLTATYLLLLAK 323
           E L +   Y+H  A Y LLL +
Sbjct: 324 ESLQNS-SYNHFAAIYYLLLER 344


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  226 bits (576), Expect = 5e-59
 Identities = 121/321 (37%), Positives = 192/321 (59%), Gaps = 10/321 (3%)

Query: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIEALKNLRHQH 68
           +Y++  T+G G FA VKL  H +T   VAIKI+DK+ L + +L +I  E++ +K L H H
Sbjct: 19  FYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPH 78

Query: 69  ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
           I +LY V+ET + +++V EY   GE+FDY+ +  RL+E E R  F QI+SAV Y H +  
Sbjct: 79  IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138

Query: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
            HRDLK ENLL D    +K+ DFG     K  +   L T CGS  YAAPE+ +G+ Y G 
Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGE--LLATWCGSPPYAAPEVFEGQQYEGP 196

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
           + D+WSMG++LYVL+CG LPFD   +  L ++++ G++ +P ++S     L+++ML +DP
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256

Query: 249 KKRISMKNLLNHPW------IMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTME 302
            KR+++  +  H W      + +   YP E +++      ++  +  +     + ++T+E
Sbjct: 257 SKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316

Query: 303 DLISLWQYDHLTATYLLLLAK 323
            L +   Y+H  A Y LL+ +
Sbjct: 317 SLQNK-SYNHFAAIYFLLVER 336


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  220 bits (560), Expect = 4e-57
 Identities = 127/338 (37%), Positives = 195/338 (57%), Gaps = 14/338 (4%)

Query: 2   KDYD-ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIE 59
           + YD ++   Y+L +T+G G FA VKLA H+ TGE VA+K++DK  L +     +  E+ 
Sbjct: 6   RGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVR 65

Query: 60  ALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR-LSEEETRVVFRQIVS 118
            +K ++H +I +LY V++T  K++++LE   GG++FDYI+  +  L+E+  +  F QIV 
Sbjct: 66  CMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVH 125

Query: 119 AVAYVHSQGYAHRDLKPENLLFDEYHKL-KLIDFGLCAKPKGNKDYHLQTCCGSLAYAAP 177
           A++Y H     HRDLKPEN++F E   L KL DFG   K +  K   L T CGSLAY+AP
Sbjct: 126 AISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK--LTTSCGSLAYSAP 183

Query: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSI 237
           E++ G  Y     D+WS+G++L++L+CG  PF + N       IM  KY VP  +S    
Sbjct: 184 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECK 243

Query: 238 LLLQQMLQVDPKKRISMKNLLNHPWIM-------QDYNYPVEWQSKNPFIHLDDDCVTEL 290
            L+ +MLQ DPK+R S++ + NHPW+          YN P+    KN      +  +  +
Sbjct: 244 DLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLV-SYKNLSEEEHNSIIQRM 302

Query: 291 SVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGK 328
            +    +R  + + +   +Y+H+TATY LL  +  R K
Sbjct: 303 VLGDIADRDAIVEALETNRYNHITATYFLLAERILREK 340


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  220 bits (560), Expect = 4e-57
 Identities = 127/338 (37%), Positives = 195/338 (57%), Gaps = 14/338 (4%)

Query: 2   KDYD-ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIE 59
           + YD ++   Y+L +T+G G FA VKLA H+ TGE VA+K++DK  L +     +  E+ 
Sbjct: 6   RGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVR 65

Query: 60  ALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR-LSEEETRVVFRQIVS 118
            +K ++H +I +LY V++T  K++++LE   GG++FDYI+  +  L+E+  +  F QIV 
Sbjct: 66  CMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVH 125

Query: 119 AVAYVHSQGYAHRDLKPENLLFDEYHKL-KLIDFGLCAKPKGNKDYHLQTCCGSLAYAAP 177
           A++Y H     HRDLKPEN++F E   L KL DFG   K +  K   L T CGSLAY+AP
Sbjct: 126 AISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK--LTTSCGSLAYSAP 183

Query: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSI 237
           E++ G  Y     D+WS+G++L++L+CG  PF + N       IM  KY VP  +S    
Sbjct: 184 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECK 243

Query: 238 LLLQQMLQVDPKKRISMKNLLNHPWIM-------QDYNYPVEWQSKNPFIHLDDDCVTEL 290
            L+ +MLQ DPK+R S++ + NHPW+          YN P+    KN      +  +  +
Sbjct: 244 DLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLV-SYKNLSEEEHNSIIQRM 302

Query: 291 SVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGK 328
            +    +R  + + +   +Y+H+TATY LL  +  R K
Sbjct: 303 VLGDIADRDAIVEALETNRYNHITATYFLLAERILREK 340


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  213 bits (542), Expect = 4e-55
 Identities = 116/264 (43%), Positives = 161/264 (60%), Gaps = 7/264 (2%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQH 68
           YEL ET+G G + KVK A    +G +VAIK + K+ +    D+  I+ EIE + +L H H
Sbjct: 55  YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114

Query: 69  ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
           I  +Y V E  +KI +++EY   GEL+DYI  + RLSE ETR  FRQIVSAV Y H  G 
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174

Query: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
            HRDLK EN+L D+   +K+ DFGL       KD  LQT CGS  YA+PE++ G+ Y G 
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGL--SNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGP 232

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSIL-LLQQMLQVD 247
           E D W++G+LLY L+ G +PFD  +   L ++I  G+Y  P    PS    L++ ML V+
Sbjct: 233 EVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP--TQPSDARGLIRWMLMVN 290

Query: 248 PKKRISMKNLLNHPWIMQDYNYPV 271
           P +R +++++ NH W+   Y   V
Sbjct: 291 PDRRATIEDIANHWWVNWGYKSSV 314


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  200 bits (509), Expect = 3e-51
 Identities = 114/283 (40%), Positives = 168/283 (59%), Gaps = 8/283 (2%)

Query: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKT-EIEALKNLRHQH 68
           +Y +   IG+G F++VKL  H LT E VAIKI+DK  L     R+ + EI +++ L H +
Sbjct: 73  FYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHHPN 132

Query: 69  ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
           I +LY V+ET +K+ +V+EY  GGELF  I ++ +LSE E++++F QIVSAV ++H    
Sbjct: 133 IIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQI 192

Query: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
            HRDLK EN+ +     +K+ DFG     K  K   L T CGS  YAAPEL + + Y+G 
Sbjct: 193 IHRDLKAENVFYTSNTCVKVGDFGFSTVSK--KGEMLNTFCGSPPYAAPELFRDEHYIGI 250

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
             D+W++G+LLY ++ G +PF  + V  L K I+ G Y VP  +S     L++ +LQ  P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELS 291
            +R  +  ++N  W MQ   YP   +   PF  LD   ++E S
Sbjct: 311 TERYGIDCIMNDEW-MQGVPYPTPLE---PF-QLDPKHLSETS 348


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  197 bits (500), Expect = 3e-50
 Identities = 101/272 (37%), Positives = 165/272 (60%), Gaps = 10/272 (3%)

Query: 2   KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEAL 61
           K  +++ K +E  ET+GTG F++V LA    TG++ A+K + K  L      I+ EI  L
Sbjct: 14  KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVL 73

Query: 62  KNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVA 121
           + ++H++I  L  + E+ N +++V++   GGELFD I+ +   +E++   + RQ++ AV 
Sbjct: 74  RKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVY 133

Query: 122 YVHSQGYAHRDLKPENLLF---DEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPE 178
           Y+H  G  HRDLKPENLL+   DE  K+ + DFGL +K +G  D  + T CG+  Y APE
Sbjct: 134 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL-SKMEGKGDV-MSTACGTPGYVAPE 191

Query: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY--DVPKW--LSP 234
           ++  K Y     D WS+G++ Y+L+CG+ PF D+N   L+++I++ +Y  D P W  +S 
Sbjct: 192 VLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD 250

Query: 235 SSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
           S+   ++ +++ DP KR + +    HPWI  D
Sbjct: 251 SAKDFIRNLMEKDPNKRYTCEQAARHPWIAGD 282


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  197 bits (500), Expect = 3e-50
 Identities = 101/272 (37%), Positives = 165/272 (60%), Gaps = 10/272 (3%)

Query: 2   KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEAL 61
           K  +++ K +E  ET+GTG F++V LA    TG++ A+K + K  L      I+ EI  L
Sbjct: 14  KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVL 73

Query: 62  KNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVA 121
           + ++H++I  L  + E+ N +++V++   GGELFD I+ +   +E++   + RQ++ AV 
Sbjct: 74  RKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVY 133

Query: 122 YVHSQGYAHRDLKPENLLF---DEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPE 178
           Y+H  G  HRDLKPENLL+   DE  K+ + DFGL +K +G  D  + T CG+  Y APE
Sbjct: 134 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL-SKMEGKGDV-MSTACGTPGYVAPE 191

Query: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY--DVPKW--LSP 234
           ++  K Y     D WS+G++ Y+L+CG+ PF D+N   L+++I++ +Y  D P W  +S 
Sbjct: 192 VLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD 250

Query: 235 SSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
           S+   ++ +++ DP KR + +    HPWI  D
Sbjct: 251 SAKDFIRNLMEKDPNKRYTCEQAARHPWIAGD 282


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  197 bits (500), Expect = 3e-50
 Identities = 111/260 (42%), Positives = 156/260 (60%), Gaps = 8/260 (3%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQH 68
           YE  ET+G G + KVK A    +G +VAIK + K+ +    DL  I+ EIE + +L H H
Sbjct: 53  YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111

Query: 69  ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
           I  ++ V E ++KI +V+EY   G+L+DYI  + +LSE E R  FRQIVSAV Y H    
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171

Query: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
            HRDLK EN+L D    +K+ DFGL       K   LQT CGS  YA+PE++ GK Y G 
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGK--FLQTFCGSPLYASPEIVNGKPYTGP 229

Query: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSIL-LLQQMLQVD 247
           E D WS+G+LLY+L+ G +PFD  +   L K+I  G Y  P    PS    L++ +L V+
Sbjct: 230 EVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP--KPSDACGLIRWLLMVN 287

Query: 248 PKKRISMKNLLNHPWIMQDY 267
           P +R +++++ +H W+   Y
Sbjct: 288 PTRRATLEDVASHWWVNWGY 307


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  197 bits (500), Expect = 3e-50
 Identities = 131/368 (35%), Positives = 196/368 (53%), Gaps = 26/368 (7%)

Query: 17  IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDL---PRIKTEIEALKNLRHQHICQLY 73
           +G G FAKV+   H+LTGE VAIK++DK     D      ++ E +  + +RH +I QL 
Sbjct: 68  LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127

Query: 74  HVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDL 133
            +LET N  ++V+E CPGG L   I  + RL E E R   RQ++SAV ++H  G  HRDL
Sbjct: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187

Query: 134 KPENLLFDEYHKLKLIDFGL--CAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEAD 191
           K ENLL DE + +KLIDFGL  CA   G  D    T CGS AYAAPEL+  K Y G + D
Sbjct: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSD-PFSTQCGSPAYAAPELLARKKY-GPKID 245

Query: 192 VWSMGILLYVLMCGFLPF--DDDNVMALYKKIMRGKYD-VPKWLSPSSILLLQQMLQVDP 248
           VWS+G+ +Y ++ G LPF  +  ++ ALY+K++  + + +P  LS  +I  L+ +L+ DP
Sbjct: 246 VWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDP 305

Query: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHR-----NNRQTMED 303
            KR +++  L + W+ ++Y   V      P     +D    + +H        N   +  
Sbjct: 306 VKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINT 365

Query: 304 LISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTAS 363
           ++S  +  H+ A Y LL  K          L  +  G++        K+  + +E   A 
Sbjct: 366 VLSN-RACHILAIYFLLNKK----------LERYLSGKSDIQDSLCYKTRLYQIEKYRAP 414

Query: 364 DKNYVAGL 371
            ++Y A L
Sbjct: 415 KESYEASL 422


>gi|27901803 protein serine kinase H1 [Homo sapiens]
          Length = 424

 Score =  183 bits (464), Expect = 5e-46
 Identities = 99/264 (37%), Positives = 158/264 (59%), Gaps = 15/264 (5%)

Query: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMD-KNTLGSDLPRIKTEIEALKNLRHQHI 69
           Y++   IG G F++V    H  T +  AIK+++ K   G ++   ++E+  L+ +RH +I
Sbjct: 98  YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREV--CESELRVLRRVRHANI 155

Query: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
            QL  V ET  +++MV+E   GGELFD II++   +E +   V + ++  V Y+H+ G  
Sbjct: 156 IQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGIT 215

Query: 130 HRDLKPENLLFDEYH-----KLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKS 184
           HRDLKPENLL+  YH     K+ + DFGL +  K   D  ++T CG+  Y APE++  K 
Sbjct: 216 HRDLKPENLLY--YHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKP 273

Query: 185 YLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDV--PKWLSPSSIL--LL 240
           Y  S  D+W++G++ Y+L+ G +PF+DDN   LY++I+RGKY      W S S++    +
Sbjct: 274 YTNS-VDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFI 332

Query: 241 QQMLQVDPKKRISMKNLLNHPWIM 264
            ++L VDP  R++    L HPW++
Sbjct: 333 DRLLTVDPGARMTALQALRHPWVV 356


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  181 bits (458), Expect = 2e-45
 Identities = 99/272 (36%), Positives = 159/272 (58%), Gaps = 11/272 (4%)

Query: 2   KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEAL 61
           K  +++   YE+ E +G+G F++V LA    +  +VA+K + K  L      ++ EI  L
Sbjct: 23  KHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVL 82

Query: 62  KNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVA 121
           + + H +I  L  V E+ + +++ +E   GGELFD I+ +   +E++   +  Q++ AV+
Sbjct: 83  RRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVS 142

Query: 122 YVHSQGYAHRDLKPENLLFD---EYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPE 178
           Y+HS G  HRDLKPENLL+    E  K+ + DFGL     GN    L T CG+  Y APE
Sbjct: 143 YLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPE 199

Query: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY--DVPKW--LSP 234
           L++ K Y G   DVW++G++ Y+L+CG+ PF D++   L+ +I+R  Y  D P W  +S 
Sbjct: 200 LLEQKPY-GKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 258

Query: 235 SSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 266
           S+   ++ +L+ DP+KR + +  L H WI  D
Sbjct: 259 SAKDFIRHLLERDPQKRFTCQQALRHLWISGD 290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,612,991
Number of Sequences: 37866
Number of extensions: 1162665
Number of successful extensions: 5076
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 712
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 2505
Number of HSP's gapped (non-prelim): 1097
length of query: 651
length of database: 18,247,518
effective HSP length: 109
effective length of query: 542
effective length of database: 14,120,124
effective search space: 7653107208
effective search space used: 7653107208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.