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Search of human proteins with 75677567
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75677567 dyslexia susceptibility 1 candidate 1 isoform b
[Homo sapiens]
(376 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75677567 dyslexia susceptibility 1 candidate 1 isoform b [Hom... 745 0.0
gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Hom... 693 0.0
gi|75677576 dyslexia susceptibility 1 candidate 1 isoform c [Hom... 691 0.0
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 60 2e-09
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre... 56 6e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 56 6e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 55 1e-07
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 55 1e-07
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 55 1e-07
gi|18375528 UPF3 regulator of nonsense transcripts homolog B iso... 54 2e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 54 2e-07
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 54 3e-07
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 54 3e-07
gi|94538370 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform ... 53 5e-07
gi|27262638 sperm associated antigen 1 [Homo sapiens] 53 5e-07
gi|27262636 sperm associated antigen 1 [Homo sapiens] 53 5e-07
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 51 1e-06
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 51 2e-06
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 51 2e-06
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 51 2e-06
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 51 2e-06
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 51 2e-06
gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens] 51 2e-06
gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens] 51 2e-06
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 50 3e-06
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 50 3e-06
gi|116686122 kinesin family member 4 [Homo sapiens] 50 3e-06
gi|88759339 aster-associated protein [Homo sapiens] 50 3e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 50 3e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 50 3e-06
>gi|75677567 dyslexia susceptibility 1 candidate 1 isoform b [Homo
sapiens]
Length = 376
Score = 745 bits (1923), Expect = 0.0
Identities = 376/376 (100%), Positives = 376/376 (100%)
Query: 1 MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE
Sbjct: 1 MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
Query: 61 SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA
Sbjct: 61 SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
Query: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK
Sbjct: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
Query: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI
Sbjct: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
Query: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL
Sbjct: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
Query: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAYRIMKRHLRL 360
FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAYRIMKRHLRL
Sbjct: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAYRIMKRHLRL 360
Query: 361 IHPTKLYKLMLRRFGM 376
IHPTKLYKLMLRRFGM
Sbjct: 361 IHPTKLYKLMLRRFGM 376
>gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Homo
sapiens]
Length = 420
Score = 693 bits (1789), Expect = 0.0
Identities = 350/354 (98%), Positives = 352/354 (99%)
Query: 1 MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE
Sbjct: 1 MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
Query: 61 SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA
Sbjct: 61 SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
Query: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK
Sbjct: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
Query: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI
Sbjct: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
Query: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL
Sbjct: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
Query: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAYRIM 354
FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKA ++
Sbjct: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELL 354
>gi|75677576 dyslexia susceptibility 1 candidate 1 isoform c [Homo
sapiens]
Length = 381
Score = 691 bits (1784), Expect = 0.0
Identities = 349/351 (99%), Positives = 350/351 (99%)
Query: 1 MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE
Sbjct: 1 MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
Query: 61 SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA
Sbjct: 61 SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
Query: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK
Sbjct: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
Query: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI
Sbjct: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
Query: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL
Sbjct: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
Query: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAY 351
FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK +
Sbjct: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKEF 351
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 60.5 bits (145), Expect = 2e-09
Identities = 70/262 (26%), Positives = 117/262 (44%), Gaps = 34/262 (12%)
Query: 58 DDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEA 117
++E+ K+K+ DT V +++A ET + D E ++ ++K + ++ KE +
Sbjct: 277 EEETVKSKVTVDTGVIPASEEKA---ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK 333
Query: 118 KAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQR 177
K +K + ++ EEEER+K E E ERIK + LEA +RK EE+ + ++
Sbjct: 334 KGPSKATVKAMQEALAKLKEEEERQKRE---EEERIKRLEELEA----KRKEEERLEQEK 386
Query: 178 EEKLCQKEKQIKEERK---KIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRS 234
E+ QKEK+ KE K K+ KS A K ++ + E +DS+P R
Sbjct: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV--EVPSKDSLPKKRP 444
Query: 235 VGSIKINFTPRVFPTALRESQVAE----------------EEEWLHKQAEARRAMNTDIA 278
+ K + P L +V+E E+E E +T+ A
Sbjct: 445 IYEDK---KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDA 501
Query: 279 ELCDLKEEEKNPEWLKDKGNKL 300
L D + + E K +GNK+
Sbjct: 502 GLDDWEAMASDEETEKVEGNKV 523
Score = 29.6 bits (65), Expect = 4.6
Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 9/67 (13%)
Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEA-WKEY 165
A + K + KA K ++K +EE+ K+ +KE E ++ K ++ KE
Sbjct: 221 ASFKIKTVAQKKAEKKERERKK--------RDEEKAKLRKLKEKEELETGKKDQSKQKES 272
Query: 166 QRKAEEQ 172
QRK EE+
Sbjct: 273 QRKFEEE 279
Score = 29.3 bits (64), Expect = 6.0
Identities = 34/162 (20%), Positives = 67/162 (41%), Gaps = 27/162 (16%)
Query: 148 KENERIKATKALEAWKE-----YQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTR 202
K+N++ K +E+ E ++ K QKK +++E+ +K + K + +K+K K
Sbjct: 201 KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE--- 257
Query: 203 NLASRNLAPKGRNSENIFTEKLKEDSIPAPRSV--GSIKINFTPRVFPTALRESQVA--- 257
K ++ + K +E+++ + +V G I + PTA +
Sbjct: 258 ---ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKK 314
Query: 258 -----------EEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
EE+E K+ ++ + L LKEEE+
Sbjct: 315 KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356
Score = 29.3 bits (64), Expect = 6.0
Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 20/119 (16%)
Query: 122 KREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQRE--- 178
K E K + V EEEE ++ E+ +E+E + + E E EE +K+ E
Sbjct: 517 KVEGNKVHIEVKENPEEEEEEE-EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDS 575
Query: 179 ----EKLCQKEKQIKEE--------RKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLK 225
+K KE E +++ Y R + R L +S+N+ TEKL+
Sbjct: 576 GKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRL----EHSKNVNTEKLR 630
>gi|41152097 DNA segment on chromosome X and Y (unique) 155
expressed sequence isoform 1 [Homo sapiens]
Length = 695
Score = 55.8 bits (133), Expect = 6e-08
Identities = 50/218 (22%), Positives = 105/218 (48%), Gaps = 15/218 (6%)
Query: 93 KEMMQRIREKSILQAQERAKEATEAKAAAKR-----EDQKYALSVMMKIEEEERKKIEDM 147
+E M I+ S L+ + + + KA A + K+ +K + ER+K++++
Sbjct: 222 REYMGFIQAMSALRGMKLMYKGEDGKAVACNIKVSFDSTKHLSDASIKKRQLERQKLQEL 281
Query: 148 KENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASR 207
++ + + EA + + + +QK+++ E+ ++E+++++ +K + + L RN +
Sbjct: 282 EQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQKQRDRELRRN--QK 339
Query: 208 NLAPKGRNSENIFTEKLKEDS---IPAPRSVGSIKI--NFTPRVFPTALRESQVAEEEEW 262
L + EK+K + + A R++ SI++ R LRE + EE+
Sbjct: 340 KLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLR 399
Query: 263 LHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
L +Q E RR AEL ++EE++ L+ K +L
Sbjct: 400 LQQQEERRRLQE---AELRRVEEEKERALGLQRKEREL 434
Score = 33.9 bits (76), Expect = 0.25
Identities = 31/145 (21%), Positives = 70/145 (48%), Gaps = 12/145 (8%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSV------MMKIEEEERKKIE 145
+ E QR E+ + +E +E + KRE ++ + + K++ EE+K+++
Sbjct: 294 EAEERQRAEERKQKELEELERERKREEKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQ 353
Query: 146 D---MKENERIKATKALEAWK---EYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKS 199
+ ++E + + A + L++ + E +A+ K ++E+K + Q +EER++++
Sbjct: 354 EKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQEAE 413
Query: 200 LTRNLASRNLAPKGRNSENIFTEKL 224
L R + A + E E+L
Sbjct: 414 LRRVEEEKERALGLQRKERELRERL 438
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 55.8 bits (133), Expect = 6e-08
Identities = 42/131 (32%), Positives = 72/131 (54%), Gaps = 8/131 (6%)
Query: 78 KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
KE A E + ++E ++ ++K I A ERA+ E KAAA+ +++ A ++
Sbjct: 262 KERAEAERARLEAEERERIKAEQDKKI--ADERARIEAEEKAAAQERERREA-EERERMR 318
Query: 138 EEERKKIED---MKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQ--IKEER 192
EEE++ E+ +KE E+ A + +E +R AEE+++I+ EEK +E+Q EE
Sbjct: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378
Query: 193 KKIKYKSLTRN 203
+K K + RN
Sbjct: 379 EKAKVEEQKRN 389
Score = 48.5 bits (114), Expect = 1e-05
Identities = 40/146 (27%), Positives = 74/146 (50%), Gaps = 12/146 (8%)
Query: 58 DDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEA 117
+++ + IG + + + +K E V + + K Q +ER + + E
Sbjct: 195 EEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK---QEEEREQGSDEI 251
Query: 118 KAAAK--REDQKYALSVMMKIEEEERKKI---EDMK---ENERIKATKALEAWKEYQRKA 169
K ED++ A + ++E EER++I +D K E RI+A + A + +R+A
Sbjct: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREA 311
Query: 170 EEQKKIQREEKLCQKEKQ-IKEERKK 194
EE+++++ EEK +E+Q IKEE K+
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKR 337
Score = 44.7 bits (104), Expect = 1e-04
Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 19/140 (13%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAK-----REDQKYALSVMMKIEEEERKKIED 146
+ E +R+RE+ A+ER + E K AA+ +E++K A +I+EEE++ E
Sbjct: 310 EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE- 368
Query: 147 MKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLAS 206
E +R +A +E + K EEQK+ ++ E EK+ + KIK + + + +
Sbjct: 369 --ERQRARAE------EEEKAKVEEQKRNKQLE-----EKKHAMQETKIKGEKVEQKIEG 415
Query: 207 RNLAPKGRNSENIFTEKLKE 226
+ + K + + T LK+
Sbjct: 416 KWVNEKKAQEDKLQTAVLKK 435
Score = 44.7 bits (104), Expect = 1e-04
Identities = 58/253 (22%), Positives = 107/253 (42%), Gaps = 60/253 (23%)
Query: 94 EMMQRIREKSILQAQERAKEATEAKAAAK-----REDQKYALSVMMKI--EEEERKKIED 146
E QRI+E+ A+ER + E K AA+ +E++K A + EEEE+ K+E+
Sbjct: 326 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385
Query: 147 MKENERI---------------KATKALEAWKEYQRKAEEQK---------------KIQ 176
K N+++ K + +E ++KA+E K K+Q
Sbjct: 386 QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQ 445
Query: 177 ------REEKLCQKEKQIKEERKK------------IKYKSLTRNLASRN---LAPKGRN 215
+E+K K+++IK+E+ K + K + S+N + K ++
Sbjct: 446 AKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKH 505
Query: 216 SENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNT 275
+EN F+ S+ + G+ ++ R+ R + EE KQ + A+
Sbjct: 506 TENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAAL-- 563
Query: 276 DIAELCDLKEEEK 288
++ EL +EE +
Sbjct: 564 ELEELKKKREERR 576
Score = 41.6 bits (96), Expect = 0.001
Identities = 49/234 (20%), Positives = 100/234 (42%), Gaps = 26/234 (11%)
Query: 78 KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
K ++ E V+++ + E ++ + + E K +RE +S K+E
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKME 258
Query: 138 EEERKKIE------DMKENERIKATKALEAWKEYQR-------KAEEQKKIQRE--EKLC 182
EE++++ E + +E ERIKA + + E R A+E+++ + E E++
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
Query: 183 QKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINF 242
++EK+ EER++IK + R R + +++KE+ A
Sbjct: 319 EEEKRAAEERQRIKEEE-KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE-------- 369
Query: 243 TPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDK 296
R A E + EE+ +KQ E ++ + + E++ +W+ +K
Sbjct: 370 --RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEK 421
Score = 35.4 bits (80), Expect = 0.084
Identities = 42/181 (23%), Positives = 83/181 (45%), Gaps = 25/181 (13%)
Query: 100 REKSILQAQERAKE----ATEAKAA--AKREDQKYALSVMMKIEE--EERKKIEDMKENE 151
R+K + +A ER KE T+A + ++R A + + EE E R++ +++E E
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETE 166
Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
+ + W++ + +E K+ + EE+ K I E + ++ + T +
Sbjct: 167 TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVM 226
Query: 212 KGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARR 271
+N + I +E+ K++ R GS +I+ ++ EEE+ ++AEA R
Sbjct: 227 SLKNGQ-ISSEEPKQEE---EREQGSDEISHHEKM-----------EEED--KERAEAER 269
Query: 272 A 272
A
Sbjct: 270 A 270
Score = 35.0 bits (79), Expect = 0.11
Identities = 24/118 (20%), Positives = 56/118 (47%), Gaps = 4/118 (3%)
Query: 113 EATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQ 172
+ EA+ A + E K + + E E ++ E +K+ ++ A + +E ++K EE+
Sbjct: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL----EELKKKREER 575
Query: 173 KKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIP 230
+K+ EE+ +K+++ + ++ + K + R A + + + L +D P
Sbjct: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKP 633
Score = 32.0 bits (71), Expect = 0.93
Identities = 33/125 (26%), Positives = 58/125 (46%), Gaps = 24/125 (19%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIE--DMKE 149
+ E +++++K QE A E E K KRE+++ L EEE+R+K E D K
Sbjct: 547 ESEEFEKLKQKQ----QEAALELEELK--KKREERRKVLE-----EEEQRRKQEEADRKL 595
Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIK-----------EERKKIKYK 198
E + + E + + +A E+++ E+ L +K K EER + K
Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 655
Query: 199 SLTRN 203
S+ ++
Sbjct: 656 SVQKS 660
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/223 (21%), Positives = 101/223 (45%), Gaps = 22/223 (9%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSV---- 132
++E M E G +E MQ+ +E+ + + +E+ ++ E + + QK V
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQK-QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQE 254
Query: 133 --MMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKE 190
M K EE+ R++ E M+E E + + +E Q +E++ ++EE++ ++E+Q++E
Sbjct: 255 EQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE 314
Query: 191 ERKKIKYKSLTRNLASRNLAPKGRNSENIFTEK-----LKEDSIPAPRSVGSIKINFTPR 245
+ ++++ + G+ E ++ +K KE +G + +
Sbjct: 315 QEEQMREQE----------EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364
Query: 246 VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
+E Q+ ++EE + KQ E R + E + E+K
Sbjct: 365 EEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQK 407
Score = 42.7 bits (99), Expect = 5e-04
Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 14/115 (12%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
K+E MWE KE M + E+ Q ++ K+ + + K+E+Q M K
Sbjct: 328 KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR---KQEEQ------MRKQ 378
Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEE 191
EE+ RK+ E M++ E + + KE + +EQ + Q E+ QKE+ K+E
Sbjct: 379 EEQMRKQEEQMRKQE-----EQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428
Score = 40.8 bits (94), Expect = 0.002
Identities = 41/208 (19%), Positives = 85/208 (40%), Gaps = 34/208 (16%)
Query: 90 GVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEE-RKKIEDMK 148
G +E ++RE+ ++ + + + ++E+Q M +EE+ RK+ E M
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237
Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRN 208
E E + ++ +E +K EEQ + Q E+ Q+E+ ++E + +K K T
Sbjct: 238 EQE-----EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 209 LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE 268
+ + E+++E +E Q+ E+EE + +Q E
Sbjct: 293 EQEEQMREQE---EQMRE-------------------------QEEQMREQEEQMREQEE 324
Query: 269 ARRAMNTDIAELCDLKEEEKNPEWLKDK 296
+ E + E+K W +++
Sbjct: 325 QMGKQEEQMWEQKEQMWEQKEQMWKQEE 352
Score = 38.1 bits (87), Expect = 0.013
Identities = 34/126 (26%), Positives = 60/126 (47%), Gaps = 14/126 (11%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
++E M E G +E M +E+ Q ++ K+ + ++E+Q M K
Sbjct: 314 EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM---GEQEEQ------MQKQ 364
Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIK 196
EE+ RK+ E M++ E + + +E RK EEQ Q+E+ QKE+ ++E + +
Sbjct: 365 EEQVRKQEEQMRKQE-----EQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGE 419
Query: 197 YKSLTR 202
K R
Sbjct: 420 QKEQMR 425
Score = 37.0 bits (84), Expect = 0.029
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 21/111 (18%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
+++++ MW+ G +E MQ+ +E+ + + +E+ + K+E+Q M
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQK-QEEQVRKQEEQMR---------KQEEQ------MR 383
Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKE 185
K EE+ RK+ E M E + + + KE R+ EEQ Q+E+ Q+E
Sbjct: 384 KQEEQMRKQEEQMGEQK-----EQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 54.7 bits (130), Expect = 1e-07
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 18/204 (8%)
Query: 97 QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKAT 156
+R++EK + +ER KE + K K +D+ +E E+ + +D +++ +
Sbjct: 388 ERVKEKDREKEREREKEREKEKERGKNKDRD---------KEREKDREKDKEKDRERERE 438
Query: 157 KALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNS 216
K E ++ +++ E+ K+ +RE+ + K+I E+RKK K KS T S N + + R+S
Sbjct: 439 KEHEKDRDKEKEKEQDKEKEREK---DRSKEIDEKRKKDK-KSRTPP-RSYNASRRSRSS 493
Query: 217 ENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTD 276
+ S +PR+ +IK + P + + E+E H R +T
Sbjct: 494 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553
Query: 277 IAELC---DLKEE-EKNPEWLKDK 296
+ + D KE+ EKN LK+K
Sbjct: 554 MRKSSNDRDGKEKLEKNSTSLKEK 577
Score = 32.0 bits (71), Expect = 0.93
Identities = 22/112 (19%), Positives = 48/112 (42%)
Query: 106 QAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEY 165
++ R+K + +K+ ++R+ + R+K ++ K +K+ E K
Sbjct: 309 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSR 368
Query: 166 QRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSE 217
R K+ EK+ +KE+ +++R+K + + R K R+ E
Sbjct: 369 SRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 54.7 bits (130), Expect = 1e-07
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 18/204 (8%)
Query: 97 QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKAT 156
+R++EK + +ER KE + K K +D+ +E E+ + +D +++ +
Sbjct: 272 ERVKEKDREKEREREKEREKEKERGKNKDRD---------KEREKDREKDKEKDRERERE 322
Query: 157 KALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNS 216
K E ++ +++ E+ K+ +RE+ + K+I E+RKK K KS T S N + + R+S
Sbjct: 323 KEHEKDRDKEKEKEQDKEKEREK---DRSKEIDEKRKKDK-KSRTPP-RSYNASRRSRSS 377
Query: 217 ENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTD 276
+ S +PR+ +IK + P + + E+E H R +T
Sbjct: 378 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 437
Query: 277 IAELC---DLKEE-EKNPEWLKDK 296
+ + D KE+ EKN LK+K
Sbjct: 438 MRKSSNDRDGKEKLEKNSTSLKEK 461
Score = 32.0 bits (71), Expect = 0.93
Identities = 22/112 (19%), Positives = 48/112 (42%)
Query: 106 QAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEY 165
++ R+K + +K+ ++R+ + R+K ++ K +K+ E K
Sbjct: 193 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSR 252
Query: 166 QRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSE 217
R K+ EK+ +KE+ +++R+K + + R K R+ E
Sbjct: 253 SRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 304
>gi|18375528 UPF3 regulator of nonsense transcripts homolog B
isoform 1 [Homo sapiens]
Length = 483
Score = 53.9 bits (128), Expect = 2e-07
Identities = 51/214 (23%), Positives = 100/214 (46%), Gaps = 14/214 (6%)
Query: 97 QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEER-KKIEDMKENERIKA 155
QR+RE+ + +ER + E K + E +K+ K ++ E+ KKI+ + E +++K
Sbjct: 208 QRMREE---KREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD 264
Query: 156 TKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRN 215
++ + + ++ +++ EK +KE +E+ KK+ ++L+ AS +
Sbjct: 265 EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKR 324
Query: 216 SENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNT 275
S++ +LK++ P R + + ++ E E L +Q E RR
Sbjct: 325 SDS----ELKDEKPKRPEDESGRDYREREREYER--DQERILRERERLKRQEEERRRQKE 378
Query: 276 --DIAELCDLKEEE--KNPEWLKDKGNKLFATEN 305
+ + KEEE K + L+DKG K +TE+
Sbjct: 379 RYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTES 412
Score = 37.4 bits (85), Expect = 0.022
Identities = 31/140 (22%), Positives = 64/140 (45%), Gaps = 12/140 (8%)
Query: 91 VDKEMMQRIREKSILQAQERAKEAT-EAKAAAKREDQKY-------ALSVMMKIEEEERK 142
V + ++Q + +K++L+ E+ E + + AK+ D++ S + +
Sbjct: 270 VHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSEL 329
Query: 143 KIEDMKENERIKATKALEAWKEYQRKAE----EQKKIQREEKLCQKEKQIKEERKKIKYK 198
K E K E E +EY+R E E+++++R+E+ +++K+ E+ K K K
Sbjct: 330 KDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRK 389
Query: 199 SLTRNLASRNLAPKGRNSEN 218
L KG+ +E+
Sbjct: 390 EEEMKKEKDTLRDKGKKAES 409
Score = 36.2 bits (82), Expect = 0.049
Identities = 30/125 (24%), Positives = 55/125 (44%), Gaps = 6/125 (4%)
Query: 94 EMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERI 153
E +R ++S +ER +E + RE ++ +K +EEER++ ++ E E+
Sbjct: 332 EKPKRPEDESGRDYREREREYERDQERILRERER------LKRQEEERRRQKERYEKEKT 385
Query: 154 KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKG 213
K E KE ++ KK + E + EK K+E + + ++ + L G
Sbjct: 386 FKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPG 445
Query: 214 RNSEN 218
S N
Sbjct: 446 ARSRN 450
Score = 30.0 bits (66), Expect = 3.5
Identities = 27/104 (25%), Positives = 51/104 (49%), Gaps = 8/104 (7%)
Query: 124 EDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQ 183
+++K + +EE E K E + + K T L K QR EE+++ +R ++ +
Sbjct: 170 DNEKMTSTPETLLEEIEAKNRELIAK----KTTPLLSFLKNKQRMREEKREERRRREI-E 224
Query: 184 KEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKED 227
+++Q +EER+K K + + L R E +KLK++
Sbjct: 225 RKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPER---DKLKDE 265
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 53.9 bits (128), Expect = 2e-07
Identities = 65/293 (22%), Positives = 129/293 (44%), Gaps = 20/293 (6%)
Query: 70 TIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYA 129
T + T+ + + M T + V K ++R + L+ + KE + ++E+ +
Sbjct: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKR---NTPLRMDPKEKERQRLENLRRKEEAEQL 550
Query: 130 LSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIK 189
K+EE++R+++E++K + K L+A R+ EQ K ++++++ QK QI
Sbjct: 551 RR--QKVEEDKRRRLEEVKLKREERLRKVLQA-----RERVEQMKEEKKKQIEQKFAQID 603
Query: 190 EERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT 249
E+ +K K + L A + A K E + + +E+ R + ++ R
Sbjct: 604 EKTEKAKEERLAEEKAKKKAAAK--KMEEVEARRKQEEE---ARRLRWLQQEEEERRHQE 658
Query: 250 ALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAA 309
L++ + EE+E L K AEA+R E + + E+ + + + E LA
Sbjct: 659 LLQKKK-EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 717
Query: 310 INAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK---AYRIMKRHLR 359
RL + L + A L+ + L + +E+ K R+ +R L+
Sbjct: 718 QERRREQERLQAERELQEREK-ALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 769
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/230 (21%), Positives = 106/230 (46%), Gaps = 44/230 (19%)
Query: 54 YAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKE 113
+A ID+++ KAK + + KK+AA +++ E + QE +E
Sbjct: 599 FAQIDEKTEKAK--EERLAEEKAKKKAAA--------------KKMEEVEARRKQE--EE 640
Query: 114 ATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQK 173
A + + E+++ ++ K +EEE++++ E +R+ + E ++ +R+ E ++
Sbjct: 641 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700
Query: 174 KIQREEKLCQKEKQIKEERKKIKYKSL--TRNLASRNLA---PKGRNSENIFTEKLKEDS 228
+ +RE++ ++E+Q+ E+ ++ + + L R L R A K + + +K KE+
Sbjct: 701 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760
Query: 229 IPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE-ARRAMNTDI 277
L E Q+ EE+E K+A A +A+N +
Sbjct: 761 --------------------QRLAERQLQEEQEKKAKEAAGASKALNVTV 790
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform
1 [Homo sapiens]
Length = 1722
Score = 53.5 bits (127), Expect = 3e-07
Identities = 54/223 (24%), Positives = 99/223 (44%), Gaps = 26/223 (11%)
Query: 97 QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIE--------DMK 148
Q + S+L+ Q A +AK A QKY + +IE ++RK E K
Sbjct: 272 QEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQK 331
Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI--KYKSLTRNLAS 206
E E K + + KE ++K +E+++ +RE++ +K+ +K+ER+++ K K + R AS
Sbjct: 332 EEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDAS 391
Query: 207 RN------LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEE 260
+ L G N++++ E + D +++ V + ES + E
Sbjct: 392 QQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKEN- 450
Query: 261 EWLHKQAEARRAMNTDIAE-------LCDLKEEEKNPEWLKDK 296
+ +Q + ++ + E L D K EEKN K +
Sbjct: 451 --VDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKR 491
Score = 37.7 bits (86), Expect = 0.017
Identities = 48/203 (23%), Positives = 91/203 (44%), Gaps = 34/203 (16%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
+K+ +EK L+AQ +E K + E++++ K+E +KK+E++++ E
Sbjct: 176 EKQKELEDKEKQTLKAQRDREE----KQFQEEEEKRHCWMKQFKVE---KKKLENIQKQE 228
Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
+ K E +KE K ++K Q EE + Q++EER + K +
Sbjct: 229 QDKMND--ELYKE--EKIWKEKFKQHEEYIRNLHLQMEEERTRFK-----------DQQE 273
Query: 212 KGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALR---ESQVAEEEEWLHKQAE 268
K +NS LK+ + A + K + + ++ ES+ + +EW K+A+
Sbjct: 274 KEKNS------LLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 327
Query: 269 ARRAMNTD---IAELCDLKEEEK 288
R+ + + E +KEE K
Sbjct: 328 IRQKEEENRKRLEEEQRIKEERK 350
Score = 33.5 bits (75), Expect = 0.32
Identities = 14/41 (34%), Positives = 28/41 (68%)
Query: 154 KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
K ++ EAW+E Q++ E+++K + + ++EKQ +EE +K
Sbjct: 166 KCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEK 206
Score = 30.0 bits (66), Expect = 3.5
Identities = 39/202 (19%), Positives = 81/202 (40%), Gaps = 8/202 (3%)
Query: 117 AKAAAKREDQKYALSVMMKIEEEERKKIED----MKENERIKATKALEAWKEYQRKAEEQ 172
AK +K ++ +EE K+ D +KE+ ++K +++ + E+
Sbjct: 423 AKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEE 482
Query: 173 KKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAP 232
K +K C +E +K+ERK Y++ N KG E ++LK D+
Sbjct: 483 KNENLAKKRCSEEL-VKQERK---YENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEE 538
Query: 233 RSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEW 292
+ + + T + L +Q E + +Q + I ++ + +E+N
Sbjct: 539 KIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLL 598
Query: 293 LKDKGNKLFATENYLAAINAYN 314
KDK + + + ++ + N
Sbjct: 599 YKDKDTLVISVKQRSLSLTSEN 620
Score = 29.3 bits (64), Expect = 6.0
Identities = 33/137 (24%), Positives = 55/137 (40%), Gaps = 7/137 (5%)
Query: 136 IEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQRE--EKLCQKEKQIKEERK 193
+ E + EN+ T + ++ K+E++KKI E K +Q+ + +
Sbjct: 1503 LSSSEHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDISTAQQMLKRAQ 1562
Query: 194 KIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIK-INFTPRVFPTALR 252
K+K K L + + S +N+EN + K + PR G + I P T
Sbjct: 1563 KMKSKKLKKKIDSTVRLALFKNNENKVSLP-KSPKMVQPRRDGYFEGIEEDPIHKDTTAN 1621
Query: 253 ESQVAEEE---EWLHKQ 266
E E +WLH Q
Sbjct: 1622 EKLERNREYTYQWLHTQ 1638
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform
2 [Homo sapiens]
Length = 1336
Score = 53.5 bits (127), Expect = 3e-07
Identities = 54/223 (24%), Positives = 99/223 (44%), Gaps = 26/223 (11%)
Query: 97 QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIE--------DMK 148
Q + S+L+ Q A +AK A QKY + +IE ++RK E K
Sbjct: 272 QEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQK 331
Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI--KYKSLTRNLAS 206
E E K + + KE ++K +E+++ +RE++ +K+ +K+ER+++ K K + R AS
Sbjct: 332 EEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDAS 391
Query: 207 RN------LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEE 260
+ L G N++++ E + D +++ V + ES + E
Sbjct: 392 QQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKEN- 450
Query: 261 EWLHKQAEARRAMNTDIAE-------LCDLKEEEKNPEWLKDK 296
+ +Q + ++ + E L D K EEKN K +
Sbjct: 451 --VDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKR 491
Score = 37.7 bits (86), Expect = 0.017
Identities = 48/203 (23%), Positives = 91/203 (44%), Gaps = 34/203 (16%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
+K+ +EK L+AQ +E K + E++++ K+E +KK+E++++ E
Sbjct: 176 EKQKELEDKEKQTLKAQRDREE----KQFQEEEEKRHCWMKQFKVE---KKKLENIQKQE 228
Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
+ K E +KE K ++K Q EE + Q++EER + K +
Sbjct: 229 QDKMND--ELYKE--EKIWKEKFKQHEEYIRNLHLQMEEERTRFK-----------DQQE 273
Query: 212 KGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALR---ESQVAEEEEWLHKQAE 268
K +NS LK+ + A + K + + ++ ES+ + +EW K+A+
Sbjct: 274 KEKNS------LLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 327
Query: 269 ARRAMNTD---IAELCDLKEEEK 288
R+ + + E +KEE K
Sbjct: 328 IRQKEEENRKRLEEEQRIKEERK 350
Score = 33.5 bits (75), Expect = 0.32
Identities = 14/41 (34%), Positives = 28/41 (68%)
Query: 154 KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
K ++ EAW+E Q++ E+++K + + ++EKQ +EE +K
Sbjct: 166 KCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEK 206
Score = 30.0 bits (66), Expect = 3.5
Identities = 39/202 (19%), Positives = 81/202 (40%), Gaps = 8/202 (3%)
Query: 117 AKAAAKREDQKYALSVMMKIEEEERKKIED----MKENERIKATKALEAWKEYQRKAEEQ 172
AK +K ++ +EE K+ D +KE+ ++K +++ + E+
Sbjct: 423 AKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEE 482
Query: 173 KKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAP 232
K +K C +E +K+ERK Y++ N KG E ++LK D+
Sbjct: 483 KNENLAKKRCSEEL-VKQERK---YENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEE 538
Query: 233 RSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEW 292
+ + + T + L +Q E + +Q + I ++ + +E+N
Sbjct: 539 KIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLL 598
Query: 293 LKDKGNKLFATENYLAAINAYN 314
KDK + + + ++ + N
Sbjct: 599 YKDKDTLVISVKQRSLSLTSEN 620
>gi|94538370 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform 1
[Homo sapiens]
Length = 621
Score = 52.8 bits (125), Expect = 5e-07
Identities = 83/348 (23%), Positives = 143/348 (41%), Gaps = 52/348 (14%)
Query: 6 SDYSWQQTKTAVFLSLPLKGVCVRDTD-VFCTENYLKVNFPPFLFEAFLYAPIDDESSK- 63
+DY TK LS P+K D F K FE F P+ + +S+
Sbjct: 135 NDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFEVF--TPVFERNSRW 192
Query: 64 ------AKIGN------DTIVFTLYKKEAAMWETLS-VTGVDKEMMQRIREKSILQAQER 110
K+G+ D +F + W S + +KE + E+ ++ Q R
Sbjct: 193 SNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNR 252
Query: 111 AKEATEAKAAAKR----EDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ 166
A A K R D Y+ +K +EE K ++ ++ + +A + + KE Q
Sbjct: 253 ATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQ 312
Query: 167 RKAE----------EQKKIQREEKLCQKEKQI-----KEERKKIKYKSLTRNLASRNLAP 211
R+AE E+++++++ L +KEK I K+ER+K++ T N S N A
Sbjct: 313 RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE 372
Query: 212 KGRNSENIFTEKLKED-SIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEAR 270
+ + E + EKL + + + + + + T V AL E Q+ E E + K+ E
Sbjct: 373 RVKMMEEV--EKLCDRLELASLQCLNETLTSCTKEVGKAAL-EKQIEEINEQIRKEKEEA 429
Query: 271 RAMNTDIAELCDLKEEEKNPEWLK---DKGNKLFATENYLAAINAYNL 315
A +++ KN E G+K ++ ++ I A NL
Sbjct: 430 EAR---------MRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNL 468
>gi|27262638 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 52.8 bits (125), Expect = 5e-07
Identities = 26/89 (29%), Positives = 51/89 (57%)
Query: 286 EEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
+EK + LK++GN+ +NY A++ Y+ +++NNK +Y NRA C+LKL +A +
Sbjct: 619 DEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQ 678
Query: 346 DSSKAYRIMKRHLRLIHPTKLYKLMLRRF 374
D +A ++ +++ + L L+ +
Sbjct: 679 DCDQALQLADGNVKAFYRRALAHKGLKNY 707
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 16/93 (17%)
Query: 288 KNPEWLKDKGNKLFATENYLAAINAYNLAIRL--------NNKMPLLYLNRAACHLKLKN 339
+NP LK +GN+LF + + A Y+ AI L + + +LY NRAAC+LK N
Sbjct: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGN 502
Query: 340 LHKAIEDSSKAYRIMKRHLRLIHPTKLYKLMLR 372
I+D ++A +HP + L+ R
Sbjct: 503 CSGCIQDCNRALE--------LHPFSMKPLLRR 527
Score = 39.7 bits (91), Expect = 0.004
Identities = 53/212 (25%), Positives = 91/212 (42%), Gaps = 25/212 (11%)
Query: 169 AEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDS 228
AEE +KI + K E + KEE K +++ T NL P ++ + K K
Sbjct: 89 AEEWEKIDGDIKSWVSEIK-KEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSK 147
Query: 229 IPAPRSVGSIKINFTPR---------VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
P + TPR V L+ + +E+ + K ++ D A
Sbjct: 148 RPTKKK--------TPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAG 199
Query: 280 LCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLL--YLNRAACHLKL 337
L + KE++ K+KGN+ F + +Y A+ Y +I + +P + Y NRA +KL
Sbjct: 200 LTE-KEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSI---SALPTVVAYNNRAQAEIKL 255
Query: 338 KNLHKAIEDSSKAYRIMKRHLR-LIHPTKLYK 368
+N + A +D K + +++ L+ YK
Sbjct: 256 QNWNSAFQDCEKVLELEPGNVKALLRRATTYK 287
>gi|27262636 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 52.8 bits (125), Expect = 5e-07
Identities = 26/89 (29%), Positives = 51/89 (57%)
Query: 286 EEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
+EK + LK++GN+ +NY A++ Y+ +++NNK +Y NRA C+LKL +A +
Sbjct: 619 DEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQ 678
Query: 346 DSSKAYRIMKRHLRLIHPTKLYKLMLRRF 374
D +A ++ +++ + L L+ +
Sbjct: 679 DCDQALQLADGNVKAFYRRALAHKGLKNY 707
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 16/93 (17%)
Query: 288 KNPEWLKDKGNKLFATENYLAAINAYNLAIRL--------NNKMPLLYLNRAACHLKLKN 339
+NP LK +GN+LF + + A Y+ AI L + + +LY NRAAC+LK N
Sbjct: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGN 502
Query: 340 LHKAIEDSSKAYRIMKRHLRLIHPTKLYKLMLR 372
I+D ++A +HP + L+ R
Sbjct: 503 CSGCIQDCNRALE--------LHPFSMKPLLRR 527
Score = 39.7 bits (91), Expect = 0.004
Identities = 53/212 (25%), Positives = 91/212 (42%), Gaps = 25/212 (11%)
Query: 169 AEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDS 228
AEE +KI + K E + KEE K +++ T NL P ++ + K K
Sbjct: 89 AEEWEKIDGDIKSWVSEIK-KEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSK 147
Query: 229 IPAPRSVGSIKINFTPR---------VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
P + TPR V L+ + +E+ + K ++ D A
Sbjct: 148 RPTKKK--------TPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAG 199
Query: 280 LCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLL--YLNRAACHLKL 337
L + KE++ K+KGN+ F + +Y A+ Y +I + +P + Y NRA +KL
Sbjct: 200 LTE-KEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSI---SALPTVVAYNNRAQAEIKL 255
Query: 338 KNLHKAIEDSSKAYRIMKRHLR-LIHPTKLYK 368
+N + A +D K + +++ L+ YK
Sbjct: 256 QNWNSAFQDCEKVLELEPGNVKALLRRATTYK 287
>gi|24308141 small glutamine-rich tetratricopeptide repeat
(TPR)-containing, beta [Homo sapiens]
Length = 304
Score = 51.2 bits (121), Expect = 1e-06
Identities = 31/90 (34%), Positives = 44/90 (48%)
Query: 285 EEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAI 344
E+ + LKD+GN ENY AA++ Y AI L+ + Y NRAA KL + AI
Sbjct: 80 EDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAI 139
Query: 345 EDSSKAYRIMKRHLRLIHPTKLYKLMLRRF 374
+D KA I ++ + L L +F
Sbjct: 140 KDCEKAIAIDSKYSKAYGRMGLALTALNKF 169
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 50.8 bits (120), Expect = 2e-06
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 30/174 (17%)
Query: 180 KLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIK 239
+LC+K ++ E ++ Y+ + + A R + F E+ +D+I S+
Sbjct: 280 ELCEKAIEVGRENRE-DYRQIAKAYA--------RIGNSYFKEEKYKDAIHFYNK--SLA 328
Query: 240 INFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNK 299
+ TP V L++ Q AE+ + K+ E +N D+A EEKN KGN+
Sbjct: 329 EHRTPDV----LKKCQQAEK---ILKEQERLAYINPDLAL------EEKN------KGNE 369
Query: 300 LFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAYRI 353
F +Y A+ Y AI+ N K LY NRAAC+ KL A++D + ++
Sbjct: 370 CFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQL 423
Score = 43.1 bits (100), Expect = 4e-04
Identities = 23/57 (40%), Positives = 33/57 (57%)
Query: 293 LKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK 349
LK+KGNK + N A+ Y+ AI+L+ +LY NR+A + K + KA ED K
Sbjct: 7 LKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCK 63
Score = 29.6 bits (65), Expect = 4.6
Identities = 68/305 (22%), Positives = 114/305 (37%), Gaps = 64/305 (20%)
Query: 84 ETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKK 143
+ LSV +D + +Q E L + + A AK+ D + A E+ K
Sbjct: 13 KALSVGNID-DALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAY--------EDGCK 63
Query: 144 IEDMKEN------ERIKATKALEAWKEYQRKAEEQKKI-----QREEKLCQKEKQIKEER 192
D+K + + A + L ++E +R EE K Q +E L E ++ E +
Sbjct: 64 TVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERK 123
Query: 193 -----------KKIKYKSLTRNLAS----RNLAPKGRNSENIFTEKLKEDSIPAPRSV-- 235
+K++ TR L S R L + RN + KL++ I SV
Sbjct: 124 FMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLL 183
Query: 236 ----GSIKIN---FTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
GS+ TP P +E++ EE DL E +K
Sbjct: 184 GVDLGSMDEEEEIATPPPPPPPKKETKPEPMEE--------------------DLPENKK 223
Query: 289 NPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSS 348
K+ GN + +++ A+ Y+ A L+ N+AA + + + +K E
Sbjct: 224 QALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCE 283
Query: 349 KAYRI 353
KA +
Sbjct: 284 KAIEV 288
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 50.8 bits (120), Expect = 2e-06
Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)
Query: 81 AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
++W+ T ++++++ +A + +E EA+ AKRE++ +
Sbjct: 702 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 761
Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
++ + +EEERK+ E+ +E R K +AL +E + R+ EE+++ Q+EE L + E++
Sbjct: 762 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 820
Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
+EE ++ K + L R A K E +L+E+ + ++ R
Sbjct: 821 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 876
Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
+E +V ++E + ++ + + A+
Sbjct: 877 --KRKELEVQRQKELMRQRQQQQEAL 900
Score = 48.1 bits (113), Expect = 1e-05
Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)
Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
A E+ ++ +AKAA K E ++ + K EEEERK+ E+++ ++ + K
Sbjct: 716 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 774
Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
E + +RK EE + QRE+++ + ++ +EER+ + + R L R + R +
Sbjct: 775 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 832
Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
K +E++ R EEEE + E R M + A
Sbjct: 833 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 868
Query: 280 LCDLKEEEKNPE 291
L +EE K E
Sbjct: 869 LRHEEEERKRKE 880
Score = 46.2 bits (108), Expect = 5e-05
Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
++E+ +R +E+++ + +E+ + +R+ Q+ AL + + EEEER+K E++
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 835
Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
+ +A K +E QR+ EE + EE + ++ + +RK++ + K L R
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895
Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
+ A + R + ++L + +P+ + G + T +L E Q EEE
Sbjct: 896 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 954
Query: 266 QAEARR 271
+ E RR
Sbjct: 955 REEQRR 960
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 50.8 bits (120), Expect = 2e-06
Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)
Query: 81 AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
++W+ T ++++++ +A + +E EA+ AKRE++ +
Sbjct: 729 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 788
Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
++ + +EEERK+ E+ +E R K +AL +E + R+ EE+++ Q+EE L + E++
Sbjct: 789 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 847
Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
+EE ++ K + L R A K E +L+E+ + ++ R
Sbjct: 848 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 903
Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
+E +V ++E + ++ + + A+
Sbjct: 904 --KRKELEVQRQKELMRQRQQQQEAL 927
Score = 48.1 bits (113), Expect = 1e-05
Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)
Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
A E+ ++ +AKAA K E ++ + K EEEERK+ E+++ ++ + K
Sbjct: 743 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 801
Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
E + +RK EE + QRE+++ + ++ +EER+ + + R L R + R +
Sbjct: 802 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 859
Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
K +E++ R EEEE + E R M + A
Sbjct: 860 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 895
Query: 280 LCDLKEEEKNPE 291
L +EE K E
Sbjct: 896 LRHEEEERKRKE 907
Score = 46.2 bits (108), Expect = 5e-05
Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
++E+ +R +E+++ + +E+ + +R+ Q+ AL + + EEEER+K E++
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 862
Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
+ +A K +E QR+ EE + EE + ++ + +RK++ + K L R
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922
Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
+ A + R + ++L + +P+ + G + T +L E Q EEE
Sbjct: 923 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 981
Query: 266 QAEARR 271
+ E RR
Sbjct: 982 REEQRR 987
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 50.8 bits (120), Expect = 2e-06
Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)
Query: 81 AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
++W+ T ++++++ +A + +E EA+ AKRE++ +
Sbjct: 708 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 767
Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
++ + +EEERK+ E+ +E R K +AL +E + R+ EE+++ Q+EE L + E++
Sbjct: 768 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826
Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
+EE ++ K + L R A K E +L+E+ + ++ R
Sbjct: 827 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 882
Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
+E +V ++E + ++ + + A+
Sbjct: 883 --KRKELEVQRQKELMRQRQQQQEAL 906
Score = 48.1 bits (113), Expect = 1e-05
Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)
Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
A E+ ++ +AKAA K E ++ + K EEEERK+ E+++ ++ + K
Sbjct: 722 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 780
Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
E + +RK EE + QRE+++ + ++ +EER+ + + R L R + R +
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 838
Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
K +E++ R EEEE + E R M + A
Sbjct: 839 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 874
Query: 280 LCDLKEEEKNPE 291
L +EE K E
Sbjct: 875 LRHEEEERKRKE 886
Score = 46.2 bits (108), Expect = 5e-05
Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
++E+ +R +E+++ + +E+ + +R+ Q+ AL + + EEEER+K E++
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
+ +A K +E QR+ EE + EE + ++ + +RK++ + K L R
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
+ A + R + ++L + +P+ + G + T +L E Q EEE
Sbjct: 902 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 960
Query: 266 QAEARR 271
+ E RR
Sbjct: 961 REEQRR 966
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 50.8 bits (120), Expect = 2e-06
Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)
Query: 81 AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
++W+ T ++++++ +A + +E EA+ AKRE++ +
Sbjct: 708 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 767
Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
++ + +EEERK+ E+ +E R K +AL +E + R+ EE+++ Q+EE L + E++
Sbjct: 768 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826
Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
+EE ++ K + L R A K E +L+E+ + ++ R
Sbjct: 827 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 882
Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
+E +V ++E + ++ + + A+
Sbjct: 883 --KRKELEVQRQKELMRQRQQQQEAL 906
Score = 48.1 bits (113), Expect = 1e-05
Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)
Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
A E+ ++ +AKAA K E ++ + K EEEERK+ E+++ ++ + K
Sbjct: 722 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 780
Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
E + +RK EE + QRE+++ + ++ +EER+ + + R L R + R +
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 838
Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
K +E++ R EEEE + E R M + A
Sbjct: 839 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 874
Query: 280 LCDLKEEEKNPE 291
L +EE K E
Sbjct: 875 LRHEEEERKRKE 886
Score = 46.2 bits (108), Expect = 5e-05
Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)
Query: 92 DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
++E+ +R +E+++ + +E+ + +R+ Q+ AL + + EEEER+K E++
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841
Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
+ +A K +E QR+ EE + EE + ++ + +RK++ + K L R
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
+ A + R + ++L + +P+ + G + T +L E Q EEE
Sbjct: 902 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 960
Query: 266 QAEARR 271
+ E RR
Sbjct: 961 REEQRR 966
>gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens]
Length = 929
Score = 50.8 bits (120), Expect = 2e-06
Identities = 27/73 (36%), Positives = 45/73 (61%), Gaps = 3/73 (4%)
Query: 293 LKDKGNKLFATENYLAAINAYNLAIRLNNKMPL---LYLNRAACHLKLKNLHKAIEDSSK 349
LK++GN+ F ++Y AA N+Y+ A++L L LY NRAAC LK ++ +A D+S+
Sbjct: 9 LKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASR 68
Query: 350 AYRIMKRHLRLIH 362
A I ++ ++
Sbjct: 69 AIDINSSDIKALY 81
>gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens]
Length = 931
Score = 50.8 bits (120), Expect = 2e-06
Identities = 27/73 (36%), Positives = 45/73 (61%), Gaps = 3/73 (4%)
Query: 293 LKDKGNKLFATENYLAAINAYNLAIRLNNKMPL---LYLNRAACHLKLKNLHKAIEDSSK 349
LK++GN+ F ++Y AA N+Y+ A++L L LY NRAAC LK ++ +A D+S+
Sbjct: 9 LKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASR 68
Query: 350 AYRIMKRHLRLIH 362
A I ++ ++
Sbjct: 69 AIDINSSDIKALY 81
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 50.4 bits (119), Expect = 3e-06
Identities = 54/232 (23%), Positives = 103/232 (44%), Gaps = 32/232 (13%)
Query: 77 KKEAAMWETLSVTGVDKEMM------QRIREKSILQAQERAKEATEAKAAAKREDQKYAL 130
++E MWE +EMM R +E+ + + +E+ +E E K +Q+
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE-----KMHEQEKIR 407
Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQ-KKIQREEKLCQKEKQIK 189
K +EEE+ + ++ ++ + K + E +E + K EQ KK+ R+E+ ++++I+
Sbjct: 408 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 467
Query: 190 EERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT 249
EE K+ + + + R K E I+ +K K K+
Sbjct: 468 EEEKRQEQEEMWRQ------EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV--------- 512
Query: 250 ALRESQVAEEEEWLHKQAEARRAMNTDIAELCDL-KEEEKNPE----WLKDK 296
+E ++ E+EE + +Q E I E ++ +EEEK E W ++K
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564
Score = 46.6 bits (109), Expect = 4e-05
Identities = 45/208 (21%), Positives = 104/208 (50%), Gaps = 21/208 (10%)
Query: 93 KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI-EEEERKKIEDM--KE 149
+E ++IRE+ + R +E + RE++K + KI EEE+R++ ED ++
Sbjct: 520 REQEEKIREQE--EKMWRQEEKIREQEEMWREEEK--MHEQEKIWEEEKRQEQEDKMWRQ 575
Query: 150 NERIKATKALEAWKEYQR-KAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRN 208
E+I+ + + W++ ++ + +E+K+ ++EEK+ ++E++I+E+ +KI+ +
Sbjct: 576 EEKIREQEE-KVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQE--------- 625
Query: 209 LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE 268
K R E E+ +E + +G + + +E + +EE + +Q +
Sbjct: 626 --EKIREQEEKIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Query: 269 ARRAMNTDIAELCDLKEEEKNPEWLKDK 296
R I E ++ +E++ W +++
Sbjct: 683 KIREQEEKIREQEEMMQEQEEKMWEQEE 710
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/188 (24%), Positives = 81/188 (43%), Gaps = 20/188 (10%)
Query: 93 KEMMQRIREKSI-LQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
+E ++IRE+ ++ QE E K E + +M + EE+ R++ E M E E
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 376
Query: 152 RIKATKALEAW------KEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLA 205
+ W +E + K EQ+KI+ +E+ Q+E++I+E+ K+ + +
Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE------- 429
Query: 206 SRNLAPKGRNSENI--FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWL 263
A R E I EK++E R I R + ++ +EE +
Sbjct: 430 ----AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 485
Query: 264 HKQAEARR 271
H+Q E R
Sbjct: 486 HEQEEIWR 493
Score = 44.7 bits (104), Expect = 1e-04
Identities = 29/108 (26%), Positives = 57/108 (52%), Gaps = 13/108 (12%)
Query: 93 KEMMQRIRE-KSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEE---EERKKIEDMK 148
+E ++IRE + + Q QE E K + E + M + EE E+ KKI + +
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688
Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIK 196
E R +E + +E+K ++EEK+C++E++++E+ +K++
Sbjct: 689 EKIR---------EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727
Score = 43.1 bits (100), Expect = 4e-04
Identities = 42/211 (19%), Positives = 96/211 (45%), Gaps = 10/211 (4%)
Query: 93 KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
+E +++R + + ++ K + + ++E++ MM +EE+ ++ E+M +
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 390
Query: 153 IKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASR---NL 209
K + E E ++ E+++K Q EEK+ ++EK+ ++E K + + R +
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 210 APKGRNSENIF-TEKLKEDSIPAPRSV---GSIKINFTPRVFPTALRESQVAEEEEWLHK 265
R E I EK++E+ + KI+ ++ ++ ++ E+EE + K
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW---RQKEKMHEQEEKIRK 507
Query: 266 QAEARRAMNTDIAELCDLKEEEKNPEWLKDK 296
Q E I E + E++ W +++
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEKMWRQEE 538
Score = 42.4 bits (98), Expect = 7e-04
Identities = 37/207 (17%), Positives = 94/207 (45%), Gaps = 21/207 (10%)
Query: 97 QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKAT 156
++I E+ + Q+ E K K+E++ + ++ +EE+ ++ E+ + K
Sbjct: 483 EKIHEQEEIWRQKEKMHEQEEKIR-KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIR 541
Query: 157 KALEAWKEYQRKAE------EQKKIQREEKLCQKEKQIKEERKKI-KYKSLTRNLASRNL 209
+ E W+E ++ E E+K+ ++E+K+ ++E++I+E+ +K+ + + R +
Sbjct: 542 EQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601
Query: 210 APKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEA 269
+ + + EK++E I+ +E ++ E+EE +Q E
Sbjct: 602 EQEEKMWKQ--EEKIREQEEKIQEQEEKIR-----------EQEEKIREQEEMTQEQEEK 648
Query: 270 RRAMNTDIAELCDLKEEEKNPEWLKDK 296
+ E + +E++ W +++
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEE 675
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/125 (23%), Positives = 64/125 (51%), Gaps = 6/125 (4%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQ---ERAKEATEAKAAAKREDQKYALSVM 133
++E +W +E Q EK Q + E+ ++ E + + +++K
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640
Query: 134 MKIEEEER--KKIEDMKENERIKATKALEAWKEYQRKAEEQKKI-QREEKLCQKEKQIKE 190
M E+EE+ ++ E M E E + W++ ++ E++KKI ++EEK+ ++E+ ++E
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE 700
Query: 191 ERKKI 195
+ +K+
Sbjct: 701 QEEKM 705
Score = 39.3 bits (90), Expect = 0.006
Identities = 30/132 (22%), Positives = 68/132 (51%), Gaps = 25/132 (18%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
++E MW +E R +E+ + + +E+ +E E KR++Q+ + +
Sbjct: 567 EQEDKMWR--------QEEKIREQEEKVWRQEEKIREQEE-----KRQEQEEKMWKQEEK 613
Query: 137 EEEERKKIEDMKEN-----ERIKATKALEAWKEYQRKAEEQKKIQREEK-------LCQK 184
E+ +KI++ +E E+I+ + + +E + +E+K ++EEK + ++
Sbjct: 614 IREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQ 673
Query: 185 EKQIKEERKKIK 196
E++I+E+ KKI+
Sbjct: 674 EEKIREQEKKIR 685
Score = 38.1 bits (87), Expect = 0.013
Identities = 29/126 (23%), Positives = 63/126 (50%), Gaps = 10/126 (7%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKRED----QKYAL 130
L +K A + E L + +K +Q + K + + ERAK + D + ++
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQ-LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277
Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKE 190
S ++ + EE + + + + K + E +E++ K +EQ EEK+ ++E++I+E
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ-----EEKIREQEEKIRE 332
Query: 191 ERKKIK 196
+ +K++
Sbjct: 333 QEEKMR 338
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 50.4 bits (119), Expect = 3e-06
Identities = 40/152 (26%), Positives = 74/152 (48%), Gaps = 14/152 (9%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
+ ++E MWE +E M R E+ L QE+ E K + E M
Sbjct: 350 MQEQEEKMWEQEEKMREQEEKMWRQEER--LWEQEKQMREQEQKMRDQEER-------MW 400
Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
+ +E R+K E M+E E K + +E +E ++ E++KK + +E+ Q+E++I+E KK
Sbjct: 401 EQDERLREKEERMREQE--KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
Query: 195 IKYKSLTRNLASRNLAPKGRNSENIFTEKLKE 226
++ + T + + EN++ ++ KE
Sbjct: 459 MREEEETMREQEEKMQ---KQEENMWEQEEKE 487
Score = 50.1 bits (118), Expect = 3e-06
Identities = 43/212 (20%), Positives = 94/212 (44%), Gaps = 38/212 (17%)
Query: 93 KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
+E + +RE+ L+ QE + E K + E + M + EE ++ + M+E E+
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390
Query: 153 IKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPK 212
+ W++ +R E++++++ +EK+ ++ ++++EE+K + + TR+
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ-------- 442
Query: 213 GRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRA 272
EK++E+ RE ++ EEEE + +Q E
Sbjct: 443 --------EEKMQEEE-------------------RIREREKKMREEEETMREQEE---K 472
Query: 273 MNTDIAELCDLKEEEKNPEWLKDKGNKLFATE 304
M + + +E+E + L ++ KL+ E
Sbjct: 473 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504
Score = 46.6 bits (109), Expect = 4e-05
Identities = 43/222 (19%), Positives = 94/222 (42%), Gaps = 2/222 (0%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
++E MWE ++ M E+ + QE+ K+ + + + E++ M+
Sbjct: 541 EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600
Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQ--KKIQREEKLCQKEKQIKEERKK 194
EEE ++ E+ + + K + E E + K +EQ K ++EEK+ ++E+++ E+++
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
Query: 195 IKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRES 254
+ K K + E E+ K + + + RE
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 255 QVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDK 296
++ EEEE + +Q E + + E + E++ W +++
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEE 762
Score = 46.2 bits (108), Expect = 5e-05
Identities = 34/128 (26%), Positives = 63/128 (49%), Gaps = 10/128 (7%)
Query: 78 KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
+E MWE +KE R +EK Q ++ +E + K DQ+ + +I
Sbjct: 395 QEERMWEQDERLR-EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 138 EEERKKIED---MKENERIKATKALEAWKE------YQRKAEEQKKIQREEKLCQKEKQI 188
E E+K E+ M+E E + W++ QR E+++K+ +EK+ ++E++I
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 189 KEERKKIK 196
E+ +KI+
Sbjct: 514 WEQEEKIR 521
Score = 45.4 bits (106), Expect = 8e-05
Identities = 30/122 (24%), Positives = 65/122 (53%), Gaps = 10/122 (8%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
+ ++E MWE +E MQ EK Q ++ ++ + + +QK L
Sbjct: 619 MQEQEEKMWE-------QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
K++E+E+ + ++ K E+ K K + E ++K +Q+K++ EE + ++EK+++EE +
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQ---EQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 195 IK 196
++
Sbjct: 729 MR 730
Score = 42.7 bits (99), Expect = 5e-04
Identities = 35/148 (23%), Positives = 73/148 (49%), Gaps = 5/148 (3%)
Query: 75 LYKKEAAMWETLSVTGVDK--EMMQRI--REKSILQAQERAKEATEAKAAAKREDQKYAL 130
L +++ +WE + +K E ++I +EK + QE+ K+ + + + E +
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719
Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLC-QKEKQIK 189
M + EE R++ E M+E E + E W++ ++ E+++K+ +++L QKEK +
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 190 EERKKIKYKSLTRNLASRNLAPKGRNSE 217
E+ + + K + R+ K R E
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQE 807
Score = 42.4 bits (98), Expect = 7e-04
Identities = 25/108 (23%), Positives = 63/108 (58%), Gaps = 4/108 (3%)
Query: 93 KEMMQRIREKSILQAQERAKEATEAKAAAKR-EDQKYALSVMMK--IEEEERKKIEDMKE 149
K+ ++EK L E+++ K ++ E K+ L + ++EE ++ E+++E
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283
Query: 150 NERIKATKALEAWKEYQRKAEEQKKI-QREEKLCQKEKQIKEERKKIK 196
E+ + + W++ +R E++ K+ ++EEK+ ++EK+++E+ K+++
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331
Score = 42.4 bits (98), Expect = 7e-04
Identities = 26/125 (20%), Positives = 68/125 (54%), Gaps = 7/125 (5%)
Query: 75 LYKKEAAMWETLSVTGVDK---EMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALS 131
L +++ +WE + ++ E ++IR++ + QE K+ + ++EDQ +
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE--KKMWRQEKMREQEDQMWEQE 550
Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEE 191
M+ +E++ E+ E + + K + W + ++ EE++ +RE+K+ ++E+ ++E+
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEK--KTWDQEEKMREEERMREREKKMREEEEMMREQ 608
Query: 192 RKKIK 196
+K++
Sbjct: 609 EEKMQ 613
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/120 (25%), Positives = 67/120 (55%), Gaps = 11/120 (9%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAK--REDQKYALSVMM 134
+++ MWE + +K+M ++ EK +E+ +E + K RE+++ M
Sbjct: 414 REQEKMWEQVEKMREEKKMQEQ--EKKTRDQEEKMQEEERIREREKKMREEEE----TMR 467
Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQIKEERK 193
+ EE+ +K+ E+M E E + + + E + K EQ+K+Q +EEK+ ++E++I+++ +
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525
Score = 39.7 bits (91), Expect = 0.004
Identities = 43/222 (19%), Positives = 104/222 (46%), Gaps = 15/222 (6%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
L KK A + E L + +K +Q + K + + ERAK +++ + +
Sbjct: 223 LKKKNAELQEKLPLAESEKSEIQ-LNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 281
Query: 135 KIEEEERKKIEDM--KENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEER 192
+ +E++ +K E+ ++ ER++ +E + + +E+K ++E++L ++EK+++E+
Sbjct: 282 REQEKKIRKQEEKMWRQEERLRE-------QEGKMREQEEKMWRQEKRLREQEKELREQE 334
Query: 193 KKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSI---KINFTPRVFPT 249
K+++ + R + + + E EK++E R + + +
Sbjct: 335 KELREQKELREQEEQMQEQEEKMWEQ--EEKMREQEEKMWRQEERLWEQEKQMREQEQKM 392
Query: 250 ALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPE 291
+E ++ E++E L ++ E R ++ ++EE+K E
Sbjct: 393 RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434
Score = 35.4 bits (80), Expect = 0.084
Identities = 27/123 (21%), Positives = 66/123 (53%), Gaps = 12/123 (9%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQA---QERAKEATEAKAAAKREDQKYALSVM 133
++E +M E ++EMM+ EK Q QE+ +E E + +++K
Sbjct: 710 REEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Query: 134 MKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQIKEER 192
+ ++E+ + E M+E E+I W++ ++ ++++K++ +EEK+ +E++++ +
Sbjct: 770 LPEQKEKLWEHEKMQEQEKI--------WEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE 821
Query: 193 KKI 195
+K+
Sbjct: 822 EKM 824
Score = 34.3 bits (77), Expect = 0.19
Identities = 40/172 (23%), Positives = 77/172 (44%), Gaps = 25/172 (14%)
Query: 74 TLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKRE--------- 124
++ ++E M E + +E MQ EK +Q QE E K + E
Sbjct: 714 SMREREKKMREEEEMMREQEEKMQEQEEK--MQEQEEEMWEQEEKMWEQEEKMWEQQRLP 771
Query: 125 DQKYALSVMMKIEEEER-----KKIEDMKEN-----ERIKATKALEAWKEYQRKAEEQKK 174
+QK L K++E+E+ +K+ D +E E+++ + +E + +E+K
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831
Query: 175 IQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKE 226
+EEK+ +E+++ + +K++ K + R K R E EK++E
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQE----EKMRE 879
Score = 34.3 bits (77), Expect = 0.19
Identities = 26/129 (20%), Positives = 62/129 (48%), Gaps = 7/129 (5%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQ--RIREKSILQAQERAKEATEAKAAAKREDQKYALSV 132
++++E MWE + +++ + +++E+ + QE E K + E +
Sbjct: 757 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK 816
Query: 133 MMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAE-----EQKKIQREEKLCQKEKQ 187
M EE+ + E M E + + W + ++ E E+K ++EEK+ +E++
Sbjct: 817 MRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876
Query: 188 IKEERKKIK 196
++E+ +K++
Sbjct: 877 MREQEEKMR 885
Score = 32.0 bits (71), Expect = 0.93
Identities = 24/123 (19%), Positives = 62/123 (50%), Gaps = 3/123 (2%)
Query: 75 LYKKEAAMWETLSVTGVDK--EMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSV 132
L +++ +WE + +K E +++R++ + K + + +E++ +
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829
Query: 133 MMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEER 192
M +EE+ E+ + K + ++ +E R+ EE+ + Q EEK+ ++E++++ +
Sbjct: 830 KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ-EEKMREQEEKMRGQE 888
Query: 193 KKI 195
+KI
Sbjct: 889 EKI 891
>gi|116686122 kinesin family member 4 [Homo sapiens]
Length = 1232
Score = 50.4 bits (119), Expect = 3e-06
Identities = 53/223 (23%), Positives = 99/223 (44%), Gaps = 30/223 (13%)
Query: 96 MQRIREKSILQAQERAKEATEAKAAAKREDQKYAL--------------SVMMKIEEEER 141
+Q+ +E+ +L+ Q K+A +AK + +R + L S ++K++E
Sbjct: 571 LQKEKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTE 630
Query: 142 KKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYK--S 199
+ + K N+ I+ K Q K + +K Q ++K ++ Q+KE +K +Y+
Sbjct: 631 RTVS--KLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLK 688
Query: 200 LTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPR-VFPTALR------ 252
L RN ++ + + E K +D++ R V + R + TA R
Sbjct: 689 LERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLG 748
Query: 253 ---ESQVAEEE--EWLHKQAEARRAMNTDIAELCDLKEEEKNP 290
E V+ EE L+ E R+ + D+A+L + KE +NP
Sbjct: 749 NEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESGENP 791
Score = 29.6 bits (65), Expect = 4.6
Identities = 22/97 (22%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 111 AKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAE 170
A+ TE +A R +Q++ V+ + + ++ ++ + K+ E + K + + + E
Sbjct: 910 AEIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAE-KQLEESVSEKEQQLLSTLKCQDE 968
Query: 171 EQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASR 207
E +K++ ++C++ +Q+ E + IK K +ASR
Sbjct: 969 ELEKMR---EVCEQNQQLLRENEIIKQKLTLLQVASR 1002
>gi|88759339 aster-associated protein [Homo sapiens]
Length = 647
Score = 50.4 bits (119), Expect = 3e-06
Identities = 40/156 (25%), Positives = 75/156 (48%), Gaps = 5/156 (3%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
L KK + E + ++ E ++ E+ +E A + EA A K ++ K ++
Sbjct: 433 LEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAK-KIAAKK 491
Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQR---KAEEQKKIQREEKLCQKEKQIKEE 191
++EE+ +KK E+ + +A +A E WKE + K + +K+ + E QKE++ E
Sbjct: 492 RLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAE 551
Query: 192 RKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKED 227
+KK ++ + + K + E I EK KE+
Sbjct: 552 KKKDNLTAVEKWNEKKEAFFKQKEKEKI-NEKRKEE 586
Score = 40.8 bits (94), Expect = 0.002
Identities = 44/185 (23%), Positives = 85/185 (45%), Gaps = 28/185 (15%)
Query: 60 ESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQA--QERAKEATEA 117
ES +I N+ KK A E L+ K M ++ +K + +E+ K+ TE
Sbjct: 450 ESENLRIQNEQ------KKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEE 503
Query: 118 KAAAKRED-----QKYALSVMMKIEEEERKKIE-----DMKENERIKATK-----ALEAW 162
+ AA++ + +K+ M ++E+ RK+ E KE E + K A+E W
Sbjct: 504 ENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKW 563
Query: 163 KE-----YQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSE 217
E +++K +E+ +R+E+L + EK+ K+++ +Y+ N + + +
Sbjct: 564 NEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKR 623
Query: 218 NIFTE 222
+ F E
Sbjct: 624 HSFLE 628
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/133 (28%), Positives = 66/133 (49%), Gaps = 11/133 (8%)
Query: 93 KEMMQRIREKSILQAQ-ERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
++ M+ ++EK+ + + ERAK+ E + A+++ + +E+ KK K+ E
Sbjct: 521 EKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDN-----LTAVEKWNEKKEAFFKQKE 575
Query: 152 RIKAT-KALEAWKEYQRKAEEQKKIQREEK-LCQKEKQIKEERKKIKYKSLTRNLASRNL 209
+ K K E K ++K ++++ I EK L KEKQ + ERK+ K S L S L
Sbjct: 576 KEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSF---LESEAL 632
Query: 210 APKGRNSENIFTE 222
P S +F +
Sbjct: 633 PPWSPPSRTVFAK 645
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 50.1 bits (118), Expect = 3e-06
Identities = 47/217 (21%), Positives = 99/217 (45%), Gaps = 16/217 (7%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
++E MW +E +Q EK ++ QE E K E + +M +
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEK--IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 342
Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIK 196
EE+ R+ E M E E+I+ + E +E ++ E++K+ ++E K+ ++E++I+E+ +KI+
Sbjct: 343 EEKIRELEEKMHEQEKIREQE--EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400
Query: 197 YKSLTRNLASRNLAPKGRNSENIF--TEKLKEDSIPAPRSVGSIKINFTPRVFPTALRES 254
+ + G E ++ E+++E R I+ + +E
Sbjct: 401 EQ---EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR----EQEKKIREQEE 453
Query: 255 QVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPE 291
++ E+EE + +Q E M ++C+ + + + E
Sbjct: 454 KIREQEEMMQEQEE---KMGEQEGKMCEQEAKMQEQE 487
Score = 46.2 bits (108), Expect = 5e-05
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 12/129 (9%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRIRE-KSILQAQERAKEATEAKAAAKREDQKYALSVMMK 135
++EA MW +E ++IRE + ++Q QE E K + E+ + M +
Sbjct: 380 EQEAKMWRQEEKI---REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRR 436
Query: 136 IEE---EERKKI----EDMKENERIKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQ 187
EE E+ KKI E ++E E + + + ++ + E++ K+Q +EEK+ ++E++
Sbjct: 437 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEK 496
Query: 188 IKEERKKIK 196
I+E+ KKI+
Sbjct: 497 IREQEKKIR 505
Score = 46.2 bits (108), Expect = 5e-05
Identities = 33/133 (24%), Positives = 73/133 (54%), Gaps = 13/133 (9%)
Query: 77 KKEAAMWETLSVTGVDKEMMQRI------REKSILQAQERAKEATEA--KAAAKREDQKY 128
++E MWE +E M+R +EK I + +E+ +E E + K +Q+
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEG 474
Query: 129 AL----SVMMKIEEEERKKIEDMKENER-IKATKALEAWKEYQRKAEEQKKIQREEKLCQ 183
+ + M + EE+ R++ E ++E E+ I+ + +E + +E+K ++EEK+C+
Sbjct: 475 KMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 534
Query: 184 KEKQIKEERKKIK 196
+E++++E+ +K++
Sbjct: 535 QEEKMQEQEEKMR 547
Score = 44.7 bits (104), Expect = 1e-04
Identities = 26/105 (24%), Positives = 61/105 (58%), Gaps = 3/105 (2%)
Query: 93 KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
+EMMQ EK + QE EAK + E + + + E++ R++ E ++E E
Sbjct: 459 EEMMQEQEEK--MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 153 IKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQIKEERKKIK 196
+ + + W++ ++ E+++K+Q +EEK+ ++E++++E+ +++
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLR 561
Score = 37.7 bits (86), Expect = 0.017
Identities = 45/212 (21%), Positives = 93/212 (43%), Gaps = 20/212 (9%)
Query: 78 KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
+E +W L+ +E M R EK QER ++ E + + +++K M + E
Sbjct: 274 EENELWNRLNQQ--QEEKMWRQEEK----IQEREEKIQEQEEKIREQEEK-----MRRQE 322
Query: 138 EEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLC-QKEKQIKEERKKIK 196
E +K E M+ E + W++ ++ E ++K+ +EK+ Q+EK+ +EE+ + +
Sbjct: 323 EMMWEKEEKMRRQEEMM-------WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 197 YKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQV 256
K + K R E E+ +E +G + + +E ++
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQ-EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKM 434
Query: 257 AEEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
+EE + +Q + R I E ++ +E++
Sbjct: 435 RRQEEKIREQEKKIREQEEKIREQEEMMQEQE 466
Score = 36.2 bits (82), Expect = 0.049
Identities = 42/206 (20%), Positives = 91/206 (44%), Gaps = 13/206 (6%)
Query: 75 LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKRED----QKYAL 130
L +K A + E L + +K +Q + K + + ERAK + D + ++
Sbjct: 207 LKEKNAKLQEKLQLVESEKSEIQ-LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 265
Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKI--QREEKLCQKEKQI 188
S ++ + EE + + + + K + E +E + K +EQ++ ++EEK+ ++E+ +
Sbjct: 266 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325
Query: 189 KEERKKIKYKS---LTRNLASRNLAPKGRNSENIFTEKLK---EDSIPAPRSVGSIKINF 242
E+ +K++ + + R L K E I ++ K E+ I +
Sbjct: 326 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 385
Query: 243 TPRVFPTALRESQVAEEEEWLHKQAE 268
+ +E ++ E+EE + +Q E
Sbjct: 386 WRQEEKIREQEEKIREQEEMMQEQEE 411
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 50.1 bits (118), Expect = 3e-06
Identities = 66/296 (22%), Positives = 130/296 (43%), Gaps = 22/296 (7%)
Query: 70 TIVFTLYKKEAAMWETLSVTGVDKEMMQR---IREKSILQAQERAKEATEAKAAAKREDQ 126
T + T+ + + M T + V K ++R +R E+ ++ E +R+++
Sbjct: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLEN---LRRKEE 550
Query: 127 KYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEK 186
L K+EE++R+++E++K + K L+A R+ EQ K ++++++ QK
Sbjct: 551 AEQLR-RQKVEEDKRRRLEEVKLKREERLRKVLQA-----RERVEQMKEEKKKQIEQKFA 604
Query: 187 QIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRV 246
QI E+ +K K + L A + A K E + + +E+ R + ++ R
Sbjct: 605 QIDEKTEKAKEERLAEEKAKKKAAAK--KMEEVEARRKQEEE---ARRLRWLQQEEEERR 659
Query: 247 FPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENY 306
L++ + EE+E L K AEA+R E + + E+ + + + E
Sbjct: 660 HQELLQKKK-EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718
Query: 307 LAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK---AYRIMKRHLR 359
LA RL + L + A L+ + L + +E+ K R+ +R L+
Sbjct: 719 LAEQERRREQERLQAERELQEREK-ALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 773
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/230 (21%), Positives = 106/230 (46%), Gaps = 44/230 (19%)
Query: 54 YAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKE 113
+A ID+++ KAK + + KK+AA +++ E + QE +E
Sbjct: 603 FAQIDEKTEKAK--EERLAEEKAKKKAAA--------------KKMEEVEARRKQE--EE 644
Query: 114 ATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQK 173
A + + E+++ ++ K +EEE++++ E +R+ + E ++ +R+ E ++
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 704
Query: 174 KIQREEKLCQKEKQIKEERKKIKYKSL--TRNLASRNLA---PKGRNSENIFTEKLKEDS 228
+ +RE++ ++E+Q+ E+ ++ + + L R L R A K + + +K KE+
Sbjct: 705 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
Query: 229 IPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE-ARRAMNTDI 277
L E Q+ EE+E K+A A +A+N +
Sbjct: 765 --------------------QRLAERQLQEEQEKKAKEAAGASKALNVTV 794
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,205,472
Number of Sequences: 37866
Number of extensions: 589097
Number of successful extensions: 11469
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 331
Number of HSP's successfully gapped in prelim test: 704
Number of HSP's that attempted gapping in prelim test: 4775
Number of HSP's gapped (non-prelim): 3842
length of query: 376
length of database: 18,247,518
effective HSP length: 104
effective length of query: 272
effective length of database: 14,309,454
effective search space: 3892171488
effective search space used: 3892171488
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.