BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|74315350 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] (839 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|74315354 transient receptor potential cation channel, subfami... 1689 0.0 gi|74315352 transient receptor potential cation channel, subfami... 1689 0.0 gi|74315350 transient receptor potential cation channel, subfami... 1689 0.0 gi|74315348 transient receptor potential cation channel, subfami... 1689 0.0 gi|22547184 transient receptor potential cation channel, subfami... 685 0.0 gi|20127551 transient receptor potential cation channel, subfami... 631 0.0 gi|21735483 transient receptor potential cation channel, subfami... 543 e-154 gi|22547180 transient receptor potential cation channel, subfami... 372 e-102 gi|21314682 transient receptor potential cation channel, subfami... 242 9e-64 gi|17505200 transient receptor potential cation channel, subfami... 240 3e-63 gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 54 5e-07 gi|6912736 transient receptor potential cation channel, subfamil... 51 4e-06 gi|209863032 transient receptor potential cation channel, subfam... 50 7e-06 gi|209863030 transient receptor potential cation channel, subfam... 50 7e-06 gi|209863026 transient receptor potential cation channel, subfam... 50 7e-06 gi|209863024 transient receptor potential cation channel, subfam... 50 7e-06 gi|7706747 transient receptor potential cation channel, subfamil... 50 7e-06 gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 50 7e-06 gi|116534990 ankyrin-like protein 1 [Homo sapiens] 48 3e-05 gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 48 4e-05 gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 47 7e-05 gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 47 7e-05 gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 47 7e-05 gi|4507685 transient receptor potential cation channel, subfamil... 46 1e-04 gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 46 1e-04 gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 46 1e-04 gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 46 1e-04 gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 46 1e-04 gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 46 1e-04 gi|209863028 transient receptor potential cation channel, subfam... 46 2e-04 >gi|74315354 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 1689 bits (4375), Expect = 0.0 Identities = 839/839 (100%), Positives = 839/839 (100%) Query: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP Sbjct: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 Query: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE Sbjct: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 >gi|74315352 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 1689 bits (4375), Expect = 0.0 Identities = 839/839 (100%), Positives = 839/839 (100%) Query: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP Sbjct: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 Query: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE Sbjct: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 >gi|74315350 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 1689 bits (4375), Expect = 0.0 Identities = 839/839 (100%), Positives = 839/839 (100%) Query: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP Sbjct: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 Query: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE Sbjct: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 >gi|74315348 transient receptor potential cation channel, subfamily V, member 1 [Homo sapiens] Length = 839 Score = 1689 bits (4375), Expect = 0.0 Identities = 839/839 (100%), Positives = 839/839 (100%) Query: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP Sbjct: 1 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60 Query: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE Sbjct: 61 VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120 Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180 Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240 Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300 Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360 Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420 Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480 Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540 Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600 Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660 Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720 Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780 Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839 >gi|22547184 transient receptor potential cation channel, subfamily V, member 4 isoform a [Homo sapiens] Length = 871 Score = 685 bits (1768), Expect = 0.0 Identities = 352/708 (49%), Positives = 498/708 (70%), Gaps = 16/708 (2%) Query: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169 L++++R +F+ V++ + DL+ LL FL KK LTD EF++P TGKTCL KA+LNL +G Sbjct: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205 Query: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229 +N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR V LLV GADV Sbjct: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265 Query: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289 A A G FF+ FYFGELPLSLAACTNQ IV +L +N + AD+ +DS GNTVL Sbjct: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325 Query: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349 HALV +ADNT +NTKFVT MY+ +L+ A+L P LE + N G++PL +AA TGKIG+ Sbjct: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGI 385 Query: 350 LAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETP 408 +I++RE+ + + RHLSRKF +WAYGPV+SSLYDLS +DTC E+ SVLE++ Y +S+ Sbjct: 386 FQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVY-NSKIE 444 Query: 409 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEK 468 NRH+ML VEP+N LL+DKW +F FY N + Y M+IFT+ AYY+P++G PP+ Sbjct: 445 NRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRT 504 Query: 469 TGDYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATV 527 T DY R+ GE++++ GV FFF I+ F+++ P + +LF+D ++L+F+ S+ ++ + Sbjct: 505 TVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSA 564 Query: 528 VLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVF 587 LY + ++ Y+A MVF+L LGW N LY+TRG + G Y++MI+K++ +DL RF+ VY++F Sbjct: 565 ALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLF 624 Query: 588 LFGFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGM 645 + G+++A+V+L+ N + +E ++ P+CR DS S + L+LFK TIGM Sbjct: 625 MIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCR--DSETFSTF--LLDLFKLTIGM 680 Query: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705 GDLE + + VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A T Sbjct: 681 GDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATT 740 Query: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765 ILD E+SF +RKAFRSG+++ VG + DG D RWCFRVDEVNW+ WN N+GIINEDPG Sbjct: 741 ILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPG 800 Query: 766 NCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813 E + FS R+ W ++VP + E + +++ P+EV Sbjct: 801 KNE-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 841 >gi|20127551 transient receptor potential cation channel, subfamily V, member 2 [Homo sapiens] Length = 764 Score = 631 bits (1627), Expect = 0.0 Identities = 343/697 (49%), Positives = 464/697 (66%), Gaps = 19/697 (2%) Query: 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172 +DR +F AV++ +DL L +L K+ K+LTD+E+ + TGKTCL+KA+LNL DG N Sbjct: 74 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 133 Query: 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232 I LL+I R + + + LVNA TD YY+G +ALHIAIE+R++ V LLVENGA+V A A Sbjct: 134 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 193 Query: 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292 G FF+K +G FYFGELPLSLAACT Q +V +LL+N Q A + A DS GNTVLHAL Sbjct: 194 CGRFFQKGQGTC-FYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 252 Query: 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352 V ++DN+A+N VTSMY+ +L GA+L PT++LE++ N + +TPL LAA GKI + + Sbjct: 253 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 312 Query: 353 ILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHD 412 ILQRE HLSRKFTEW YGPV SLYDL+ +D+CE+NSVLE+IA+ ++P+RH Sbjct: 313 ILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC-KSPHRHR 369 Query: 413 MLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV---DGLPPFKMEKT 469 M+++EPLN+LLQ KWD + + F+ NFL +YM IFT AY++P P K E Sbjct: 370 MVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAE-V 427 Query: 470 GDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529 G+ +TG IL +LGG+Y + YF +R + F+DSY E+LF Q+L + + VL Sbjct: 428 GNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVL 487 Query: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589 F ++ Y+ +V +L LGW N+LYYTRGFQ GIY+VMI+K+ILRDL RF+ +Y+VFLF Sbjct: 488 CFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF 547 Query: 590 GFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPD----SSYNSLYSTCLELFKFTIGM 645 GF+ A+V+L ++ P+ + P D + Y + LELFKFTIGM Sbjct: 548 GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGM 607 Query: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705 G+L F E F+ + ++LLLAYV+LTYILLLNMLIALM ETVN +A +S +IWKLQ+AI+ Sbjct: 608 GELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAIS 667 Query: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765 +L+ E + C RK R+G +L VG PDG D RWCFRV+EVNW +W + + EDP Sbjct: 668 VLEMENGYWWC-RKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPS 726 Query: 766 NCEGVKRTLSFSLRSS----RVSGRHWKNFALVPLLR 798 GV RTL + +S G +N+ V LL+ Sbjct: 727 GA-GVPRTLENPVLASPPKEDEDGASEENYVPVQLLQ 762 >gi|21735483 transient receptor potential cation channel, subfamily V, member 3 [Homo sapiens] Length = 790 Score = 543 bits (1398), Expect = e-154 Identities = 295/663 (44%), Positives = 414/663 (62%), Gaps = 40/663 (6%) Query: 115 RRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKD--------PETGKTCLLKAMLNL 166 ++ IF AV++ ++L LL+ LQ+ + D + D +TGKTCL+KA+LN+ Sbjct: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179 Query: 167 HDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGA 226 + + +LL A + D L +NA YT+ Y+GQTAL+IAIERR + LL+ GA Sbjct: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239 Query: 227 DVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGN 286 DV A A G FF GFYFGE PL+LAACTNQ IV+ L+++ + DI++RDS GN Sbjct: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEH--EQTDITSRDSRGN 297 Query: 287 TVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346 +LHALV VA++ FV MY+ IL+ +LE N G+TPL LAA GK Sbjct: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353 Query: 347 IGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSE 406 +L YIL REI+E R LSRKFT+WAYGPV SSLYDL+ +DT NSVLE+ Y+++ Sbjct: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTN- 412 Query: 407 TPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRP--VDGLP-P 463 NRH+ML +EPL+ LL KW +F K +F+ +F Y Y I T+ +YYRP + +P P Sbjct: 413 IDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHP 472 Query: 464 FKMEKTGDYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSMKTLFVDSYSEMLFFLQSLF 522 + + ++ G + ++ + + GI FL R ++++ D++ +FF+Q++ Sbjct: 473 LALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVL 532 Query: 523 MLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMF 582 ++ +V LY KEY+A +V ++ALGW NMLYYTRGFQ MG+Y+VMI+K+IL D+ +F+F Sbjct: 533 VILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLF 592 Query: 583 VYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFT 642 VYIVFL GF A+ +LIE D+ SSY S LELFK T Sbjct: 593 VYIVFLLGFGVALASLIEKCPKDNKDC----------------SSYGSFSDAVLELFKLT 636 Query: 643 IGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQR 702 IG+GDL +N + +F+ LL+ YVILT++LLLNMLIALMGETV +++ES+ IW+LQR Sbjct: 637 IGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQR 696 Query: 703 AITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINE 762 A TIL+ EK + +R FR G+L +V +DD+R C R++EV WT W T+V +NE Sbjct: 697 ARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHVSFLNE 751 Query: 763 DPG 765 DPG Sbjct: 752 DPG 754 >gi|22547180 transient receptor potential cation channel, subfamily V, member 4 isoform b [Homo sapiens] Length = 811 Score = 372 bits (954), Expect = e-102 Identities = 214/586 (36%), Positives = 336/586 (57%), Gaps = 69/586 (11%) Query: 286 NTVLHALVEVADNTADNTKFVTSMYNEI-----------------------LMLGAKLHP 322 N + L+++A+ T + +F+ S + +I + GA +H Sbjct: 207 NDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHA 266 Query: 323 TLKLEELTNKK-------GMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY 375 + K G PL+LAA T + ++ Y+ + ++ + R + + Sbjct: 267 QARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLH 326 Query: 376 GPVH------------SSLYDLSCIDTCE--KNSVLEVIAYSSSETP-----------NR 410 V + +YDL + +S LE + + +P NR Sbjct: 327 ALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNR 386 Query: 411 HDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG 470 H+ML VEP+N LL+DKW +F FY N + Y M+IFT+ AYY+P++G PP+ T Sbjct: 387 HEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTV 446 Query: 471 DYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529 DY R+ GE++++ GV FFF I+ F+++ P + +LF+D ++L+F+ S+ ++ + L Sbjct: 447 DYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAAL 506 Query: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589 Y + ++ Y+A MVF+L LGW N LY+TRG + G Y++MI+K++ +DL RF+ VY++F+ Sbjct: 507 YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMI 566 Query: 590 GFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGMGD 647 G+++A+V+L+ N + +E ++ P+CR ++ L L+LFK TIGMGD Sbjct: 567 GYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFL----LDLFKLTIGMGD 622 Query: 648 LEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITIL 707 LE + + VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A TIL Sbjct: 623 LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTIL 682 Query: 708 DTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNC 767 D E+SF +RKAFRSG+++ VG + DG D RWCFRVDEVNW+ WN N+GIINEDPG Sbjct: 683 DIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKN 742 Query: 768 EGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813 E + FS R+ W ++VP + E + +++ P+EV Sbjct: 743 E-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 781 Score = 256 bits (653), Expect = 8e-68 Identities = 137/261 (52%), Positives = 179/261 (68%) Query: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169 L++++R +F+ V++ + DL+ LL FL KK LTD EF++P TGKTCL KA+LNL +G Sbjct: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205 Query: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229 +N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR V LLV GADV Sbjct: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265 Query: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289 A A G FF+ FYFGELPLSLAACTNQ IV +L +N + AD+ +DS GNTVL Sbjct: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325 Query: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349 HALV +ADNT +NTKFVT MY+ +L+ A+L P LE + N G++PL +AA TGKIG Sbjct: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGN 385 Query: 350 LAYILQREIQEPECRHLSRKF 370 +L E R RKF Sbjct: 386 RHEMLAVEPINELLRDKWRKF 406 >gi|21314682 transient receptor potential cation channel, subfamily V, member 6 [Homo sapiens] Length = 725 Score = 242 bits (618), Expect = 9e-64 Identities = 177/562 (31%), Positives = 274/562 (48%), Gaps = 78/562 (13%) Query: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244 ++ ELV T Y+GQTALHIA+ +NM LV L+ A V A A G F+++ Sbjct: 100 EAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNL 159 Query: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304 YFGE PLS AAC N IV+ L+++ ADI A+DS+GNTVLH L+ N Sbjct: 160 -IYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210 Query: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364 F MYN +L L+ + N +G+TP LA G + +++Q+ Sbjct: 211 FACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262 Query: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423 RK T+W YGP+ S+LYDL+ ID+ ++ S+LE+I +++ +L P+ L+ Sbjct: 263 ---RKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELII--TTKKREARQILDQTPVKELV 317 Query: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG------------- 470 KW R+ + F +Y LY+I FTM YRP L P +T Sbjct: 318 SLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRP---LKPRTNNRTSPRDNTLLQQKLLQ 374 Query: 471 -------DYFRVTGEILSVLGGVYF--------FFRGIQYFLQRRPSMKTLFVDSYSEML 515 D R+ GE+++V+G + F G+ F + + +L Sbjct: 375 EAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQT------ILGGPFHVL 428 Query: 516 FFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILR 575 + +L T+V+ V M F+L LGW N++Y+ RGFQ +G + +MI+KMI Sbjct: 429 IITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFG 488 Query: 576 DLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTC 635 DL RF ++ V + GF++A + + + E H + P +L+ST Sbjct: 489 DLMRFCWLMAVVILGFASAFYIIFQ-----TEDPEELGHFYDYPM---------ALFST- 533 Query: 636 LELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESK 695 ELF TI G + N D ++ I A+ I+ +L+LN+LIA+MG+T ++A E Sbjct: 534 FELF-LTIIDGPANY--NVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERD 590 Query: 696 NIWKLQRAITILDTEKSFLKCM 717 +W+ Q T + E+ +C+ Sbjct: 591 ELWRAQIVATTVMLERKLPRCL 612 >gi|17505200 transient receptor potential cation channel, subfamily V, member 5 [Homo sapiens] Length = 729 Score = 240 bits (613), Expect = 3e-63 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%) Query: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244 ++ ELV T + GQTALHIA+ +N+ LV L+ A V A A G F+++ R Sbjct: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158 Query: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304 YFGE PLS AAC N IV+ L+++ ADI A+DS+GNTVLH L+ N Sbjct: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210 Query: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364 F MYN +L L+ + N +G+TP LA G + +++Q+ Sbjct: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262 Query: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423 R+ +W YGP+ S LYDL+ ID+ E+ S LE++ SS+ +L P+ L+ Sbjct: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317 Query: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466 KW+++ + F +Y LYMI FT YRP+ L Sbjct: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377 Query: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523 E D R+ GE++S++G V I + S KT+ + ++ SL + Sbjct: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436 Query: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583 L T+V+ ++ V M F+L LGW +++Y+TRGFQ +G + +MI+KMI DL RF ++ Sbjct: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496 Query: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643 V + GF++A + + P Y T ELF I Sbjct: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541 Query: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703 D + D +F I+ A+ I+ +L+LN+ IA+MG+T ++AQE +W+ Q Sbjct: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598 Query: 704 ITILDTEKSFLKCM 717 T + E+ +C+ Sbjct: 599 ATTVMLERKLPRCL 612 >gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] Length = 4377 Score = 54.3 bits (129), Expect = 5e-07 Identities = 52/164 (31%), Positives = 75/164 (45%), Gaps = 33/164 (20%) Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252 AS + +G+TALH+A +V LV++GA V+A A D + P Sbjct: 457 ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD--------------QTP 502 Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNE 312 L ++A + IV+ LLQ Q A +A + G T LH + + D F Sbjct: 503 LHISARLGKADIVQQLLQ---QGASPNAATTSGYTPLH--LSAREGHEDVAAF------- 550 Query: 313 ILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 +L GA L +T KKG TPL +AA GK+ V +LQ+ Sbjct: 551 LLDHGASL-------SITTKKGFTPLHVAAKYGKLEVANLLLQK 587 Score = 49.7 bits (117), Expect = 1e-05 Identities = 51/169 (30%), Positives = 71/169 (42%), Gaps = 30/169 (17%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V +LV NGA+V A + F PL +AA N Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF--------------TPLYMAAQEN 151 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEI----LML 316 L +VKFLL N A S G T L ++ + + ++ L + Sbjct: 152 HLEVVKFLLDNG---ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHI 208 Query: 317 GAKLHPT----LKLE-----ELTNKKGMTPLALAAGTGKIGVLAYILQR 356 A+ T L L+ ++ +K G TPL +AA G I V +L R Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257 Score = 45.4 bits (106), Expect = 2e-04 Identities = 49/180 (27%), Positives = 69/180 (38%), Gaps = 38/180 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAA--------------AHGDFFKKTKGRPGFY 247 G T LHIA ++ M + T L+E GAD A H D GR Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690 Query: 248 -----FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADN 302 G PL LAA +++ + + L+ Q A + A+ +G T LH Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVN---QGAHVDAQTKMGYTPLH------------ 735 Query: 303 TKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPE 362 V Y I ++ L + K+ T K G TPL AA G ++ +LQ E Sbjct: 736 ---VGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/178 (27%), Positives = 72/178 (40%), Gaps = 40/178 (22%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N + LL++ GA AAA G PL +AA NQ Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN--------------GYTPLHIAAKKNQ 643 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 + I LL+ AD +A G +H + + D L+LG + Sbjct: 644 MDIATTLLEYG---ADANAVTRQGIASVHLAAQ--EGHVDMVS---------LLLGRNAN 689 Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVH 379 L+NK G+TPL LAA ++ V E+ + H+ + T+ Y P+H Sbjct: 690 -----VNLSNKSGLTPLHLAAQEDRVNV------AEVLVNQGAHVDAQ-TKMGYTPLH 735 Score = 37.7 bits (86), Expect = 0.045 Identities = 32/99 (32%), Positives = 45/99 (45%), Gaps = 17/99 (17%) Query: 192 NASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGEL 251 NA+ S G T LH+A + + + +LV GA V A +TK G Sbjct: 687 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA--------QTK------MGYT 732 Query: 252 PLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH 290 PL + + IV FLLQ+S A ++A+ G T LH Sbjct: 733 PLHVGCHYGNIKIVNFLLQHS---AKVNAKTKNGYTPLH 768 Score = 34.7 bits (78), Expect = 0.38 Identities = 57/235 (24%), Positives = 79/235 (33%), Gaps = 51/235 (21%) Query: 142 KHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLE-------------IARQTDSLK 188 K L DN + + L G + + LLLE IA + D K Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216 Query: 189 E----LVNASYTDSYYK-GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGR 243 L N + D K G T LHIA N+ + TLL+ A V A D Sbjct: 217 AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI------- 269 Query: 244 PGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNT 303 PL +A+ +VK LL A I A+ G T LH Sbjct: 270 -------TPLHVASKRGNANMVKLLLDRG---AKIDAKTRDGLTPLHCGARSGHEQV--- 316 Query: 304 KFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREI 358 + ML + P L K G++PL +A + + +LQ + Sbjct: 317 ---------VEMLLDRAAPILS----KTKNGLSPLHMATQGDHLNCVQLLLQHNV 358 >gi|6912736 transient receptor potential cation channel, subfamily C, member 5 [Homo sapiens] Length = 973 Score = 51.2 bits (121), Expect = 4e-06 Identities = 35/145 (24%), Positives = 73/145 (50%), Gaps = 8/145 (5%) Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621 +G + + +M+L D+ +F+F+Y + L F+ + L + ++ + +G C Sbjct: 503 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNC---KGIRC 558 Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677 ++++++L+ T LF G+ +L T ++F + V + Y +++ ++LLN Sbjct: 559 EKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLN 618 Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702 MLIA+M + IA + WK R Sbjct: 619 MLIAMMNNSYQLIADHADIEWKFAR 643 >gi|209863032 transient receptor potential cation channel, subfamily C, member 4 isoform zeta [Homo sapiens] Length = 804 Score = 50.4 bits (119), Expect = 7e-06 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%) Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621 +G + + +M+L D+ +F+F+Y + L F+ + L E+ +G C Sbjct: 329 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 381 Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677 ++++++L+ T LF G+ +L T ++F + V + Y +++ ++LLN Sbjct: 382 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 441 Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702 MLIA+M + IA + WK R Sbjct: 442 MLIAMMNNSYQLIADHADIEWKFAR 466 >gi|209863030 transient receptor potential cation channel, subfamily C, member 4 isoform delta [Homo sapiens] Length = 836 Score = 50.4 bits (119), Expect = 7e-06 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%) Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621 +G + + +M+L D+ +F+F+Y + L F+ + L E+ +G C Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554 Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677 ++++++L+ T LF G+ +L T ++F + V + Y +++ ++LLN Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614 Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702 MLIA+M + IA + WK R Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639 >gi|209863026 transient receptor potential cation channel, subfamily C, member 4 isoform beta [Homo sapiens] Length = 893 Score = 50.4 bits (119), Expect = 7e-06 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%) Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621 +G + + +M+L D+ +F+F+Y + L F+ + L E+ +G C Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554 Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677 ++++++L+ T LF G+ +L T ++F + V + Y +++ ++LLN Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614 Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702 MLIA+M + IA + WK R Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639 >gi|209863024 transient receptor potential cation channel, subfamily C, member 4 isoform epsilon [Homo sapiens] Length = 982 Score = 50.4 bits (119), Expect = 7e-06 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%) Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621 +G + + +M+L D+ +F+F+Y + L F+ + L E+ +G C Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554 Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677 ++++++L+ T LF G+ +L T ++F + V + Y +++ ++LLN Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614 Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702 MLIA+M + IA + WK R Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639 >gi|7706747 transient receptor potential cation channel, subfamily C, member 4 isoform alpha [Homo sapiens] Length = 977 Score = 50.4 bits (119), Expect = 7e-06 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%) Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621 +G + + +M+L D+ +F+F+Y + L F+ + L E+ +G C Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554 Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677 ++++++L+ T LF G+ +L T ++F + V + Y +++ ++LLN Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614 Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702 MLIA+M + IA + WK R Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639 >gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] Length = 1050 Score = 50.4 bits (119), Expect = 7e-06 Identities = 81/327 (24%), Positives = 120/327 (36%), Gaps = 61/327 (18%) Query: 130 LESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKE 189 L+ + L + TD FK +G ++ +L+ D T+ + D ++ Sbjct: 383 LKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEK 442 Query: 190 LVNASYTDSYY--------KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTK 241 LV+ D +G T LH+A +L+ LLV GA V A Sbjct: 443 LVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATD--------- 493 Query: 242 GRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301 Y G PL LA C V LL + +A++ +D+ GNT LH D Sbjct: 494 -----YHGATPLHLA-CQKGYQSVTLLLLHYKASAEV--QDNNGNTPLHLACTYGHE--D 543 Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR----E 357 K + E L ++ N+KG TPL +AA G GV+ +LQ E Sbjct: 544 CVKALVYYDVESCRL-----------DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTE 592 Query: 358 IQE------------------PECRHLS-RKFTEWAYGPVHSSLYDLSCIDTCEKNSVLE 398 IQ E HLS + + + PV S + I S Sbjct: 593 IQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS 652 Query: 399 VIAYSSSETPNRHDMLLVEPLNRLLQD 425 ++ SS + + D VE L R + D Sbjct: 653 SMSASSRQEETKKDYREVEKLLRAVAD 679 Score = 31.6 bits (70), Expect = 3.2 Identities = 17/37 (45%), Positives = 24/37 (64%) Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229 AS S KG TALH A+ +++ +V LL+ +GA VQ Sbjct: 834 ASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870 >gi|116534990 ankyrin-like protein 1 [Homo sapiens] Length = 1119 Score = 48.1 bits (113), Expect = 3e-05 Identities = 69/318 (21%), Positives = 128/318 (40%), Gaps = 70/318 (22%) Query: 409 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEK 468 NR ++L L KW + R N YCL +I T+ V+ P Sbjct: 693 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILV----VNIKPGMAFNS 748 Query: 469 TG----------------DYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYS 512 TG Y T IL L ++ + + Q++ + F+D + Sbjct: 749 TGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQK---RNYFMDISN 805 Query: 513 EMLFFLQS---LFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMI 569 + + + + +F+L V +HL+ ++ ++ W N L Y + F+ GI+ VM+ Sbjct: 806 VLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAI--AVYFYWMNFLLYLQRFENCGIFIVML 863 Query: 570 EKMILRDLCR--FMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSS 627 E +IL+ L R +F++++ FG S ++ ++D P S Sbjct: 864 E-VILKTLLRSTVVFIFLLLAFGLSFYILLNLQD---------------------PFSSP 901 Query: 628 YNSLYSTCLELFKFTIGMGDLEFTENY---------DFKAVFIILLLAYVILTYILLLNM 678 S+ T F++ +GD+ + E++ + L+++ I I+L+N+ Sbjct: 902 LLSIIQT------FSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNL 955 Query: 679 LIALMGETVNKIAQESKN 696 LI L V IA+ K+ Sbjct: 956 LIGL---AVGDIAEVQKH 970 Score = 30.0 bits (66), Expect = 9.3 Identities = 33/136 (24%), Positives = 57/136 (41%), Gaps = 25/136 (18%) Query: 248 FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVT 307 +G PL A NQ+ VKFLL A ++ N + A + +A V Sbjct: 97 YGNTPLHCAVEKNQIESVKFLLSR-------GANPNLRNFNMMAPLHIA---------VQ 140 Query: 308 SMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLS 367 M NE++ + + H T+ + L + G T + +A T L +L++ + C Sbjct: 141 GMNNEVMKVLLE-HRTIDV-NLEGENGNTAVIIACTTNNSEALQILLKKGAK--PC---- 192 Query: 368 RKFTEWAYGPVHSSLY 383 K +W P+H + + Sbjct: 193 -KSNKWGCFPIHQAAF 207 >gi|20270347 ankyrin repeat domain 54 [Homo sapiens] Length = 300 Score = 47.8 bits (112), Expect = 4e-05 Identities = 34/90 (37%), Positives = 44/90 (48%), Gaps = 17/90 (18%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG+TALH A N +V LL+++GAD R G G PL LAACTN Sbjct: 142 KGRTALHFASCNGNDQIVQLLLDHGAD------------PNQRDG--LGNTPLHLAACTN 187 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLH 290 + ++ LL+ A + A D G T LH Sbjct: 188 HVPVITTLLRGG---ARVDALDRAGRTPLH 214 >gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] Length = 1863 Score = 47.0 bits (110), Expect = 7e-05 Identities = 46/156 (29%), Positives = 68/156 (43%), Gaps = 33/156 (21%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 +G+TALH+A + +V L+ NGA V A A + + PL +A+ Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE--------------QTPLHIASRLG 487 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKL 320 + IV+ LLQ+ A A + G T LH + + D + + +L GA Sbjct: 488 KTEIVQLLLQH---MAHPDAATTNGYTPLH--ISAREGQVD-------VASVLLEAGA-- 533 Query: 321 HPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 L KKG TPL +AA G + V +LQR Sbjct: 534 -----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564 Score = 45.8 bits (107), Expect = 2e-04 Identities = 49/179 (27%), Positives = 72/179 (40%), Gaps = 42/179 (23%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V +LV+ GA++ A + F PL +AA N Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 120 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA------DNTKFVTSMYNEIL 314 + +VK+LL+N A+ S G T L ++ N A ++TK + L Sbjct: 121 HIDVVKYLLENG---ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL--PAL 175 Query: 315 MLGAKLHPTLKLEEL-----------------TNKKGMTPLALAAGTGKIGVLAYILQR 356 + A+ T L T + G TPL +AA G + V +L R Sbjct: 176 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234 Score = 43.9 bits (102), Expect = 6e-04 Identities = 43/148 (29%), Positives = 59/148 (39%), Gaps = 33/148 (22%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N + LL+E GA A A G PL +AA NQ Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--------------GYTPLHIAAKKNQ 620 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 + I LL +T ++ + G T LH + T M +L GA +H Sbjct: 621 MQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGH---------TDMVTLLLDKGANIH 668 Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGV 349 ++ K G+T L LAA K+ V Sbjct: 669 -------MSTKSGLTSLHLAAQEDKVNV 689 Score = 43.1 bits (100), Expect = 0.001 Identities = 48/171 (28%), Positives = 72/171 (42%), Gaps = 34/171 (19%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LHIA ++ + ++ LLV+ GA +QA G P+ +AA Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITES--------------GLTPIHVAAFMGH 422 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLH-----ALVEVADNTADNTKFVTSMYNE---I 313 L IV LLQN A + G T LH VEV N V + E Sbjct: 423 LNIVLLLLQNG---ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 479 Query: 314 LMLGAKLHPT----LKLEELTN-----KKGMTPLALAAGTGKIGVLAYILQ 355 L + ++L T L L+ + + G TPL ++A G++ V + +L+ Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530 Score = 38.1 bits (87), Expect = 0.034 Identities = 43/169 (25%), Positives = 67/169 (39%), Gaps = 38/169 (22%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAH-----------------GDFFKKTKGR 243 +G T LH+A + + +VTLL++ GA++ + D K Sbjct: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699 Query: 244 PGFY--FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301 + G PL +A + +V FLL+ Q A+++A+ G T LH + Sbjct: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLK---QGANVNAKTKNGYTPLHQAAQQGH---- 752 Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 T + N +L GAK T G T LA+A G I V+ Sbjct: 753 -----THIINVLLQHGAK-------PNATTANGNTALAIAKRLGYISVV 789 Score = 37.7 bits (86), Expect = 0.045 Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 40/214 (18%) Query: 144 LTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQ 203 L +N+ K GK L + + LLL+ D +++ T+S G Sbjct: 161 LLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES---GF 213 Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LHIA N+ + TLL+ GA V A G PL +A+ Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARN--------------GITPLHVASKRGNTN 259 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323 +VK LL Q I A+ G T LH + + +L GA L Sbjct: 260 MVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHD---------QVVELLLERGAPL--- 304 Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357 K G++PL +AA + + ++LQ + Sbjct: 305 ----LARTKNGLSPLHMAAQGDHVECVKHLLQHK 334 Score = 37.4 bits (85), Expect = 0.058 Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 33/156 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G ALH+A + ++ LV L+ G+ V +A KK G L +A+ Q Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSAT-----KK---------GNTALHIASLAGQ 88 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 +VK L++ A+I+A+ G T L+ + +N D K+ +L GA Sbjct: 89 AEVVKVLVKEG---ANINAQSQNGFTPLYMAAQ--ENHIDVVKY-------LLENGAN-- 134 Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357 + + G TPLA+A G +A +L+ + Sbjct: 135 -----QSTATEDGFTPLAVALQQGHNQAVAILLEND 165 Score = 33.9 bits (76), Expect = 0.65 Identities = 47/181 (25%), Positives = 66/181 (36%), Gaps = 52/181 (28%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LHI+ + + ++L+E GA AH KK G PL +AA Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGA-----AHSLATKK---------GFTPLHVAAKYGS 554 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 L + K LLQ +A DS G L L A DN K + + GA H Sbjct: 555 LDVAKLLLQRR------AAADSAGKNGLTPLHVAAHY--DNQKVALLLLEK----GASPH 602 Query: 322 PTLKL--------------------------EELTNKKGMTPLALAAGTGKIGVLAYILQ 355 T K + K+G+TPL LA+ G ++ +L Sbjct: 603 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662 Query: 356 R 356 + Sbjct: 663 K 663 Score = 32.0 bits (71), Expect = 2.5 Identities = 36/152 (23%), Positives = 64/152 (42%), Gaps = 33/152 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 TALH+A + + LL++ A+ A A F PL +A N++ Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF--------------TPLHIACKKNRIK 391 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323 +++ L++ A I A G T +H F+ + +L+L P Sbjct: 392 VMELLVKYG---ASIQAITESGLTPIHV-----------AAFMGHLNIVLLLLQNGASP- 436 Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQ 355 ++TN +G T L +AA G++ V+ +L+ Sbjct: 437 ----DVTNIRGETALHMAARAGQVEVVRCLLR 464 >gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] Length = 1872 Score = 47.0 bits (110), Expect = 7e-05 Identities = 46/156 (29%), Positives = 68/156 (43%), Gaps = 33/156 (21%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 +G+TALH+A + +V L+ NGA V A A + + PL +A+ Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE--------------QTPLHIASRLG 508 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKL 320 + IV+ LLQ+ A A + G T LH + + D + + +L GA Sbjct: 509 KTEIVQLLLQH---MAHPDAATTNGYTPLH--ISAREGQVD-------VASVLLEAGA-- 554 Query: 321 HPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 L KKG TPL +AA G + V +LQR Sbjct: 555 -----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585 Score = 45.8 bits (107), Expect = 2e-04 Identities = 49/179 (27%), Positives = 72/179 (40%), Gaps = 42/179 (23%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V +LV+ GA++ A + F PL +AA N Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 141 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA------DNTKFVTSMYNEIL 314 + +VK+LL+N A+ S G T L ++ N A ++TK + L Sbjct: 142 HIDVVKYLLENG---ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL--PAL 196 Query: 315 MLGAKLHPTLKLEEL-----------------TNKKGMTPLALAAGTGKIGVLAYILQR 356 + A+ T L T + G TPL +AA G + V +L R Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255 Score = 43.9 bits (102), Expect = 6e-04 Identities = 43/148 (29%), Positives = 59/148 (39%), Gaps = 33/148 (22%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N + LL+E GA A A G PL +AA NQ Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--------------GYTPLHIAAKKNQ 641 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 + I LL +T ++ + G T LH + T M +L GA +H Sbjct: 642 MQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGH---------TDMVTLLLDKGANIH 689 Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGV 349 ++ K G+T L LAA K+ V Sbjct: 690 -------MSTKSGLTSLHLAAQEDKVNV 710 Score = 43.1 bits (100), Expect = 0.001 Identities = 48/171 (28%), Positives = 72/171 (42%), Gaps = 34/171 (19%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LHIA ++ + ++ LLV+ GA +QA G P+ +AA Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITES--------------GLTPIHVAAFMGH 443 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLH-----ALVEVADNTADNTKFVTSMYNE---I 313 L IV LLQN A + G T LH VEV N V + E Sbjct: 444 LNIVLLLLQNG---ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500 Query: 314 LMLGAKLHPT----LKLEELTN-----KKGMTPLALAAGTGKIGVLAYILQ 355 L + ++L T L L+ + + G TPL ++A G++ V + +L+ Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551 Score = 38.1 bits (87), Expect = 0.034 Identities = 43/169 (25%), Positives = 67/169 (39%), Gaps = 38/169 (22%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAH-----------------GDFFKKTKGR 243 +G T LH+A + + +VTLL++ GA++ + D K Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720 Query: 244 PGFY--FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301 + G PL +A + +V FLL+ Q A+++A+ G T LH + Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLK---QGANVNAKTKNGYTPLHQAAQQGH---- 773 Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 T + N +L GAK T G T LA+A G I V+ Sbjct: 774 -----THIINVLLQHGAK-------PNATTANGNTALAIAKRLGYISVV 810 Score = 37.7 bits (86), Expect = 0.045 Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 40/214 (18%) Query: 144 LTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQ 203 L +N+ K GK L + + LLL+ D +++ T+S G Sbjct: 182 LLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES---GF 234 Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LHIA N+ + TLL+ GA V A G PL +A+ Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARN--------------GITPLHVASKRGNTN 280 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323 +VK LL Q I A+ G T LH + + +L GA L Sbjct: 281 MVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHD---------QVVELLLERGAPL--- 325 Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357 K G++PL +AA + + ++LQ + Sbjct: 326 ----LARTKNGLSPLHMAAQGDHVECVKHLLQHK 355 Score = 37.4 bits (85), Expect = 0.058 Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 33/156 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G ALH+A + ++ LV L+ G+ V +A KK G L +A+ Q Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSAT-----KK---------GNTALHIASLAGQ 109 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 +VK L++ A+I+A+ G T L+ + +N D K+ +L GA Sbjct: 110 AEVVKVLVKEG---ANINAQSQNGFTPLYMAAQ--ENHIDVVKY-------LLENGAN-- 155 Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357 + + G TPLA+A G +A +L+ + Sbjct: 156 -----QSTATEDGFTPLAVALQQGHNQAVAILLEND 186 Score = 33.9 bits (76), Expect = 0.65 Identities = 47/181 (25%), Positives = 66/181 (36%), Gaps = 52/181 (28%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LHI+ + + ++L+E GA AH KK G PL +AA Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGA-----AHSLATKK---------GFTPLHVAAKYGS 575 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 L + K LLQ +A DS G L L A DN K + + GA H Sbjct: 576 LDVAKLLLQRR------AAADSAGKNGLTPLHVAAHY--DNQKVALLLLEK----GASPH 623 Query: 322 PTLKL--------------------------EELTNKKGMTPLALAAGTGKIGVLAYILQ 355 T K + K+G+TPL LA+ G ++ +L Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683 Query: 356 R 356 + Sbjct: 684 K 684 Score = 32.0 bits (71), Expect = 2.5 Identities = 36/152 (23%), Positives = 64/152 (42%), Gaps = 33/152 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 TALH+A + + LL++ A+ A A F PL +A N++ Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF--------------TPLHIACKKNRIK 412 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323 +++ L++ A I A G T +H F+ + +L+L P Sbjct: 413 VMELLVKYG---ASIQAITESGLTPIHV-----------AAFMGHLNIVLLLLQNGASP- 457 Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQ 355 ++TN +G T L +AA G++ V+ +L+ Sbjct: 458 ----DVTNIRGETALHMAARAGQVEVVRCLLR 485 >gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] Length = 3957 Score = 47.0 bits (110), Expect = 7e-05 Identities = 46/156 (29%), Positives = 68/156 (43%), Gaps = 33/156 (21%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 +G+TALH+A + +V L+ NGA V A A + + PL +A+ Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE--------------QTPLHIASRLG 508 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKL 320 + IV+ LLQ+ A A + G T LH + + D + + +L GA Sbjct: 509 KTEIVQLLLQH---MAHPDAATTNGYTPLH--ISAREGQVD-------VASVLLEAGA-- 554 Query: 321 HPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 L KKG TPL +AA G + V +LQR Sbjct: 555 -----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585 Score = 45.8 bits (107), Expect = 2e-04 Identities = 49/179 (27%), Positives = 72/179 (40%), Gaps = 42/179 (23%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V +LV+ GA++ A + F PL +AA N Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 141 Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA------DNTKFVTSMYNEIL 314 + +VK+LL+N A+ S G T L ++ N A ++TK + L Sbjct: 142 HIDVVKYLLENG---ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL--PAL 196 Query: 315 MLGAKLHPTLKLEEL-----------------TNKKGMTPLALAAGTGKIGVLAYILQR 356 + A+ T L T + G TPL +AA G + V +L R Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255 Score = 43.9 bits (102), Expect = 6e-04 Identities = 43/148 (29%), Positives = 59/148 (39%), Gaps = 33/148 (22%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N + LL+E GA A A G PL +AA NQ Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--------------GYTPLHIAAKKNQ 641 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 + I LL +T ++ + G T LH + T M +L GA +H Sbjct: 642 MQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGH---------TDMVTLLLDKGANIH 689 Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGV 349 ++ K G+T L LAA K+ V Sbjct: 690 -------MSTKSGLTSLHLAAQEDKVNV 710 Score = 43.1 bits (100), Expect = 0.001 Identities = 48/171 (28%), Positives = 72/171 (42%), Gaps = 34/171 (19%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LHIA ++ + ++ LLV+ GA +QA G P+ +AA Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITES--------------GLTPIHVAAFMGH 443 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLH-----ALVEVADNTADNTKFVTSMYNE---I 313 L IV LLQN A + G T LH VEV N V + E Sbjct: 444 LNIVLLLLQNG---ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500 Query: 314 LMLGAKLHPT----LKLEELTN-----KKGMTPLALAAGTGKIGVLAYILQ 355 L + ++L T L L+ + + G TPL ++A G++ V + +L+ Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551 Score = 38.1 bits (87), Expect = 0.034 Identities = 43/169 (25%), Positives = 67/169 (39%), Gaps = 38/169 (22%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAH-----------------GDFFKKTKGR 243 +G T LH+A + + +VTLL++ GA++ + D K Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720 Query: 244 PGFY--FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301 + G PL +A + +V FLL+ Q A+++A+ G T LH + Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLK---QGANVNAKTKNGYTPLHQAAQQGH---- 773 Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 T + N +L GAK T G T LA+A G I V+ Sbjct: 774 -----THIINVLLQHGAK-------PNATTANGNTALAIAKRLGYISVV 810 Score = 37.7 bits (86), Expect = 0.045 Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 40/214 (18%) Query: 144 LTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQ 203 L +N+ K GK L + + LLL+ D +++ T+S G Sbjct: 182 LLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES---GF 234 Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LHIA N+ + TLL+ GA V A G PL +A+ Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARN--------------GITPLHVASKRGNTN 280 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323 +VK LL Q I A+ G T LH + + +L GA L Sbjct: 281 MVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHD---------QVVELLLERGAPL--- 325 Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357 K G++PL +AA + + ++LQ + Sbjct: 326 ----LARTKNGLSPLHMAAQGDHVECVKHLLQHK 355 Score = 37.4 bits (85), Expect = 0.058 Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 33/156 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G ALH+A + ++ LV L+ G+ V +A KK G L +A+ Q Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSAT-----KK---------GNTALHIASLAGQ 109 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 +VK L++ A+I+A+ G T L+ + +N D K+ +L GA Sbjct: 110 AEVVKVLVKEG---ANINAQSQNGFTPLYMAAQ--ENHIDVVKY-------LLENGAN-- 155 Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357 + + G TPLA+A G +A +L+ + Sbjct: 156 -----QSTATEDGFTPLAVALQQGHNQAVAILLEND 186 Score = 33.9 bits (76), Expect = 0.65 Identities = 47/181 (25%), Positives = 66/181 (36%), Gaps = 52/181 (28%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LHI+ + + ++L+E GA AH KK G PL +AA Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGA-----AHSLATKK---------GFTPLHVAAKYGS 575 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321 L + K LLQ +A DS G L L A DN K + + GA H Sbjct: 576 LDVAKLLLQRR------AAADSAGKNGLTPLHVAAHY--DNQKVALLLLEK----GASPH 623 Query: 322 PTLKL--------------------------EELTNKKGMTPLALAAGTGKIGVLAYILQ 355 T K + K+G+TPL LA+ G ++ +L Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683 Query: 356 R 356 + Sbjct: 684 K 684 Score = 32.0 bits (71), Expect = 2.5 Identities = 36/152 (23%), Positives = 64/152 (42%), Gaps = 33/152 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 TALH+A + + LL++ A+ A A F PL +A N++ Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF--------------TPLHIACKKNRIK 412 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323 +++ L++ A I A G T +H F+ + +L+L P Sbjct: 413 VMELLVKYG---ASIQAITESGLTPIHV-----------AAFMGHLNIVLLLLQNGASP- 457 Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQ 355 ++TN +G T L +AA G++ V+ +L+ Sbjct: 458 ----DVTNIRGETALHMAARAGQVEVVRCLLR 485 >gi|4507685 transient receptor potential cation channel, subfamily C, member 1 [Homo sapiens] Length = 759 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/253 (18%), Positives = 106/253 (41%), Gaps = 43/253 (16%) Query: 479 ILSVLGGVY-----FFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSH 533 IL ++G ++ ++ G++ FL+ +S +++ F + SL++ + +H Sbjct: 394 ILWIIGMIWSDIKRLWYEGLEDFLE----------ESRNQLSFVMNSLYLATFALKVVAH 443 Query: 534 LK-----------EYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMI-----LRDL 577 K + ++V + N+L Y R F +++ I L+D Sbjct: 444 NKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDF 503 Query: 578 CRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC-RPPDSSYNSLYSTCL 636 +F+ ++++ LF F+ + L + G + G C + + +++S TC Sbjct: 504 GKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCV-----GIFCEQQSNDTFHSFIGTCF 558 Query: 637 ELFKFTIGMGDLE-FTENYDF-----KAVFIILLLAYVILTYILLLNMLIALMGETVNKI 690 LF + + + F + + V +++ Y ++ I+L +L+A++ ++ I Sbjct: 559 ALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLI 618 Query: 691 AQESKNIWKLQRA 703 A WK RA Sbjct: 619 ANHEDKEWKFARA 631 >gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] Length = 1897 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252 G T LHIA ++ ++ ++ LL++ GA + A T + G LP Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 460 Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296 L +AA + K+LLQN A ++A+ T LH + Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 517 Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342 +N A+ T+ + + + + H L L KKG TPL +AA Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577 Query: 343 GTGKIGVLAYILQRE 357 GK+ V +L+R+ Sbjct: 578 KYGKVRVAELLLERD 592 Score = 42.4 bits (98), Expect = 0.002 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V LV GA+V A + F PL +AA N Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 155 Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310 L +VKFLL+N + ++ + N V H + + Sbjct: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 215 Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 N+ A L ++ +K G TPL +AA + V +L R Sbjct: 216 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261 Score = 41.6 bits (96), Expect = 0.003 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%) Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252 AS S K +T LH+A + + L++N A V A A D + P Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 506 Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300 L AA +VK LL+N+ A+ + + G+T LH AL+E + A Sbjct: 507 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563 Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 TK V + Y ++ L+L HP K G+TPL +A + ++ Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 618 Query: 351 AYILQR 356 +L R Sbjct: 619 KLLLPR 624 Score = 41.6 bits (96), Expect = 0.003 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A+ N+ +V LL+ G + A + G PL +AA NQ Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 647 Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311 + + + LLQ ++A++ V L + A+ N +T ++ Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 706 Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363 ++ + H + + + T + G TPL +A+ G I ++ ++LQ + Sbjct: 707 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 759 Query: 364 RHLSRKFTEWAYGPVHSS 381 ++ K T+ Y P+H + Sbjct: 760 --VNAK-TKLGYSPLHQA 774 Score = 38.9 bits (89), Expect = 0.020 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%) Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237 +A Q + ++ELVN A+ KG T L++A + ++ +V L+ENGA+ A F Sbjct: 120 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 178 Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291 PL++A +V L+ + I+AR+ T Sbjct: 179 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225 Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346 L +V T + + Y + + L+ + T + G+TPL +A+ G Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 284 Query: 347 IGVLAYILQREIQ 359 + ++ +L R Q Sbjct: 285 VIMVRLLLDRGAQ 297 Score = 35.0 bits (79), Expect = 0.29 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N+ LV L+++ ADV A KTK G PL AA Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 779 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306 IV LL+N ++S+ + + L +V D T FV Sbjct: 780 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 829 Score = 33.9 bits (76), Expect = 0.65 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LH A ++ + +L+++GA +QA KTK G P+ +AA + L Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 352 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305 V+ LLQ + DI+ T LH A V + N++ Sbjct: 353 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409 Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 + N + ++ L ++ +T + G+TPL +A+ G + ++ +LQR Sbjct: 410 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 459 >gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] Length = 1881 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252 G T LHIA ++ ++ ++ LL++ GA + A T + G LP Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427 Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296 L +AA + K+LLQN A ++A+ T LH + Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484 Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342 +N A+ T+ + + + + H L L KKG TPL +AA Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544 Query: 343 GTGKIGVLAYILQRE 357 GK+ V +L+R+ Sbjct: 545 KYGKVRVAELLLERD 559 Score = 42.4 bits (98), Expect = 0.002 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V LV GA+V A + F PL +AA N Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122 Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310 L +VKFLL+N + ++ + N V H + + Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182 Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 N+ A L ++ +K G TPL +AA + V +L R Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228 Score = 41.6 bits (96), Expect = 0.003 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%) Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252 AS S K +T LH+A + + L++N A V A A D + P Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473 Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300 L AA +VK LL+N+ A+ + + G+T LH AL+E + A Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530 Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 TK V + Y ++ L+L HP K G+TPL +A + ++ Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585 Query: 351 AYILQR 356 +L R Sbjct: 586 KLLLPR 591 Score = 41.6 bits (96), Expect = 0.003 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A+ N+ +V LL+ G + A + G PL +AA NQ Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614 Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311 + + + LLQ ++A++ V L + A+ N +T ++ Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673 Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363 ++ + H + + + T + G TPL +A+ G I ++ ++LQ + Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726 Query: 364 RHLSRKFTEWAYGPVHSS 381 ++ K T+ Y P+H + Sbjct: 727 --VNAK-TKLGYSPLHQA 741 Score = 38.9 bits (89), Expect = 0.020 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%) Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237 +A Q + ++ELVN A+ KG T L++A + ++ +V L+ENGA+ A F Sbjct: 87 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145 Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291 PL++A +V L+ + I+AR+ T Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192 Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346 L +V T + + Y + + L+ + T + G+TPL +A+ G Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251 Query: 347 IGVLAYILQREIQ 359 + ++ +L R Q Sbjct: 252 VIMVRLLLDRGAQ 264 Score = 35.0 bits (79), Expect = 0.29 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N+ LV L+++ ADV A KTK G PL AA Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306 IV LL+N ++S+ + + L +V D T FV Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796 Score = 33.9 bits (76), Expect = 0.65 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LH A ++ + +L+++GA +QA KTK G P+ +AA + L Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305 V+ LLQ + DI+ T LH A V + N++ Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376 Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 + N + ++ L ++ +T + G+TPL +A+ G + ++ +LQR Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426 >gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] Length = 1880 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252 G T LHIA ++ ++ ++ LL++ GA + A T + G LP Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427 Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296 L +AA + K+LLQN A ++A+ T LH + Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484 Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342 +N A+ T+ + + + + H L L KKG TPL +AA Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544 Query: 343 GTGKIGVLAYILQRE 357 GK+ V +L+R+ Sbjct: 545 KYGKVRVAELLLERD 559 Score = 42.4 bits (98), Expect = 0.002 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V LV GA+V A + F PL +AA N Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122 Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310 L +VKFLL+N + ++ + N V H + + Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182 Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 N+ A L ++ +K G TPL +AA + V +L R Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228 Score = 41.6 bits (96), Expect = 0.003 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%) Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252 AS S K +T LH+A + + L++N A V A A D + P Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473 Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300 L AA +VK LL+N+ A+ + + G+T LH AL+E + A Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530 Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 TK V + Y ++ L+L HP K G+TPL +A + ++ Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585 Query: 351 AYILQR 356 +L R Sbjct: 586 KLLLPR 591 Score = 41.6 bits (96), Expect = 0.003 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A+ N+ +V LL+ G + A + G PL +AA NQ Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614 Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311 + + + LLQ ++A++ V L + A+ N +T ++ Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673 Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363 ++ + H + + + T + G TPL +A+ G I ++ ++LQ + Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726 Query: 364 RHLSRKFTEWAYGPVHSS 381 ++ K T+ Y P+H + Sbjct: 727 --VNAK-TKLGYSPLHQA 741 Score = 38.9 bits (89), Expect = 0.020 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%) Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237 +A Q + ++ELVN A+ KG T L++A + ++ +V L+ENGA+ A F Sbjct: 87 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145 Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291 PL++A +V L+ + I+AR+ T Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192 Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346 L +V T + + Y + + L+ + T + G+TPL +A+ G Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251 Query: 347 IGVLAYILQREIQ 359 + ++ +L R Q Sbjct: 252 VIMVRLLLDRGAQ 264 Score = 35.0 bits (79), Expect = 0.29 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N+ LV L+++ ADV A KTK G PL AA Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306 IV LL+N ++S+ + + L +V D T FV Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796 Score = 33.9 bits (76), Expect = 0.65 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LH A ++ + +L+++GA +QA KTK G P+ +AA + L Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305 V+ LLQ + DI+ T LH A V + N++ Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376 Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 + N + ++ L ++ +T + G+TPL +A+ G + ++ +LQR Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426 >gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] Length = 1719 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252 G T LHIA ++ ++ ++ LL++ GA + A T + G LP Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427 Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296 L +AA + K+LLQN A ++A+ T LH + Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484 Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342 +N A+ T+ + + + + H L L KKG TPL +AA Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544 Query: 343 GTGKIGVLAYILQRE 357 GK+ V +L+R+ Sbjct: 545 KYGKVRVAELLLERD 559 Score = 42.4 bits (98), Expect = 0.002 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V LV GA+V A + F PL +AA N Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122 Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310 L +VKFLL+N + ++ + N V H + + Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182 Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 N+ A L ++ +K G TPL +AA + V +L R Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228 Score = 41.6 bits (96), Expect = 0.003 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%) Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252 AS S K +T LH+A + + L++N A V A A D + P Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473 Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300 L AA +VK LL+N+ A+ + + G+T LH AL+E + A Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530 Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 TK V + Y ++ L+L HP K G+TPL +A + ++ Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585 Query: 351 AYILQR 356 +L R Sbjct: 586 KLLLPR 591 Score = 41.6 bits (96), Expect = 0.003 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A+ N+ +V LL+ G + A + G PL +AA NQ Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614 Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311 + + + LLQ ++A++ V L + A+ N +T ++ Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673 Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363 ++ + H + + + T + G TPL +A+ G I ++ ++LQ + Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726 Query: 364 RHLSRKFTEWAYGPVHSS 381 ++ K T+ Y P+H + Sbjct: 727 --VNAK-TKLGYSPLHQA 741 Score = 38.9 bits (89), Expect = 0.020 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%) Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237 +A Q + ++ELVN A+ KG T L++A + ++ +V L+ENGA+ A F Sbjct: 87 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145 Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291 PL++A +V L+ + I+AR+ T Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192 Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346 L +V T + + Y + + L+ + T + G+TPL +A+ G Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251 Query: 347 IGVLAYILQREIQ 359 + ++ +L R Q Sbjct: 252 VIMVRLLLDRGAQ 264 Score = 35.0 bits (79), Expect = 0.29 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N+ LV L+++ ADV A KTK G PL AA Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306 IV LL+N ++S+ + + L +V D T FV Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796 Score = 33.9 bits (76), Expect = 0.65 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LH A ++ + +L+++GA +QA KTK G P+ +AA + L Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305 V+ LLQ + DI+ T LH A V + N++ Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376 Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 + N + ++ L ++ +T + G+TPL +A+ G + ++ +LQR Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426 >gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] Length = 1856 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252 G T LHIA ++ ++ ++ LL++ GA + A T + G LP Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427 Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296 L +AA + K+LLQN A ++A+ T LH + Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484 Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342 +N A+ T+ + + + + H L L KKG TPL +AA Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544 Query: 343 GTGKIGVLAYILQRE 357 GK+ V +L+R+ Sbjct: 545 KYGKVRVAELLLERD 559 Score = 42.4 bits (98), Expect = 0.002 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%) Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260 KG TALHIA +V LV GA+V A + F PL +AA N Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122 Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310 L +VKFLL+N + ++ + N V H + + Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182 Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 N+ A L ++ +K G TPL +AA + V +L R Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228 Score = 41.6 bits (96), Expect = 0.003 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%) Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252 AS S K +T LH+A + + L++N A V A A D + P Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473 Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300 L AA +VK LL+N+ A+ + + G+T LH AL+E + A Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530 Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350 TK V + Y ++ L+L HP K G+TPL +A + ++ Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585 Query: 351 AYILQR 356 +L R Sbjct: 586 KLLLPR 591 Score = 41.6 bits (96), Expect = 0.003 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A+ N+ +V LL+ G + A + G PL +AA NQ Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614 Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311 + + + LLQ ++A++ V L + A+ N +T ++ Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673 Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363 ++ + H + + + T + G TPL +A+ G I ++ ++LQ + Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726 Query: 364 RHLSRKFTEWAYGPVHSS 381 ++ K T+ Y P+H + Sbjct: 727 --VNAK-TKLGYSPLHQA 741 Score = 38.9 bits (89), Expect = 0.020 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%) Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237 +A Q + ++ELVN A+ KG T L++A + ++ +V L+ENGA+ A F Sbjct: 87 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145 Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291 PL++A +V L+ + I+AR+ T Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192 Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346 L +V T + + Y + + L+ + T + G+TPL +A+ G Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251 Query: 347 IGVLAYILQREIQ 359 + ++ +L R Q Sbjct: 252 VIMVRLLLDRGAQ 264 Score = 35.0 bits (79), Expect = 0.29 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%) Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261 G T LH+A N+ LV L+++ ADV A KTK G PL AA Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746 Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306 IV LL+N ++S+ + + L +V D T FV Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796 Score = 33.9 bits (76), Expect = 0.65 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%) Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 T LH A ++ + +L+++GA +QA KTK G P+ +AA + L Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319 Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305 V+ LLQ + DI+ T LH A V + N++ Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376 Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356 + N + ++ L ++ +T + G+TPL +A+ G + ++ +LQR Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426 >gi|209863028 transient receptor potential cation channel, subfamily C, member 4 isoform gamma [Homo sapiens] Length = 828 Score = 45.8 bits (107), Expect = 2e-04 Identities = 33/137 (24%), Positives = 69/137 (50%), Gaps = 11/137 (8%) Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621 +G + + +M+L D+ +F+F+Y + L F+ + L E+ +G C Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554 Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677 ++++++L+ T LF G+ +L T ++F + V + Y +++ ++LLN Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614 Query: 678 MLIALMGETVNKIAQES 694 MLIA+M + IA+ + Sbjct: 615 MLIAMMNNSYQLIARRA 631 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.409 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,514,703 Number of Sequences: 37866 Number of extensions: 1400277 Number of successful extensions: 5466 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 84 Number of HSP's successfully gapped in prelim test: 163 Number of HSP's that attempted gapping in prelim test: 4589 Number of HSP's gapped (non-prelim): 740 length of query: 839 length of database: 18,247,518 effective HSP length: 111 effective length of query: 728 effective length of database: 14,044,392 effective search space: 10224317376 effective search space used: 10224317376 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.