Guide to the Human Genome
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Search of human proteins with 74315348

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|74315348 transient receptor potential cation channel,
subfamily V, member 1 [Homo sapiens]
         (839 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|74315354 transient receptor potential cation channel, subfami...  1689   0.0  
gi|74315352 transient receptor potential cation channel, subfami...  1689   0.0  
gi|74315350 transient receptor potential cation channel, subfami...  1689   0.0  
gi|74315348 transient receptor potential cation channel, subfami...  1689   0.0  
gi|22547184 transient receptor potential cation channel, subfami...   685   0.0  
gi|20127551 transient receptor potential cation channel, subfami...   631   0.0  
gi|21735483 transient receptor potential cation channel, subfami...   543   e-154
gi|22547180 transient receptor potential cation channel, subfami...   372   e-102
gi|21314682 transient receptor potential cation channel, subfami...   242   9e-64
gi|17505200 transient receptor potential cation channel, subfami...   240   3e-63
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         54   5e-07
gi|6912736 transient receptor potential cation channel, subfamil...    51   4e-06
gi|209863032 transient receptor potential cation channel, subfam...    50   7e-06
gi|209863030 transient receptor potential cation channel, subfam...    50   7e-06
gi|209863026 transient receptor potential cation channel, subfam...    50   7e-06
gi|209863024 transient receptor potential cation channel, subfam...    50   7e-06
gi|7706747 transient receptor potential cation channel, subfamil...    50   7e-06
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     50   7e-06
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                     48   3e-05
gi|20270347 ankyrin repeat domain 54 [Homo sapiens]                    48   4e-05
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        47   7e-05
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         47   7e-05
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         47   7e-05
gi|4507685 transient receptor potential cation channel, subfamil...    46   1e-04
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        46   1e-04
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         46   1e-04
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         46   1e-04
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         46   1e-04
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         46   1e-04
gi|209863028 transient receptor potential cation channel, subfam...    46   2e-04

>gi|74315354 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score = 1689 bits (4375), Expect = 0.0
 Identities = 839/839 (100%), Positives = 839/839 (100%)

Query: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60
           MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
Sbjct: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60

Query: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120
           VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
Sbjct: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120

Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180
           AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180

Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240
           ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240

Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300
           KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300

Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360
           DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360

Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420
           PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420

Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480
           RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480

Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540
           SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540

Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600
           MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600

Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660
           DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660

Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720
           IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720

Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780
           FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780

Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839
           SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839


>gi|74315352 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score = 1689 bits (4375), Expect = 0.0
 Identities = 839/839 (100%), Positives = 839/839 (100%)

Query: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60
           MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
Sbjct: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60

Query: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120
           VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
Sbjct: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120

Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180
           AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180

Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240
           ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240

Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300
           KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300

Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360
           DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360

Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420
           PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420

Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480
           RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480

Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540
           SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540

Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600
           MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600

Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660
           DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660

Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720
           IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720

Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780
           FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780

Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839
           SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839


>gi|74315350 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score = 1689 bits (4375), Expect = 0.0
 Identities = 839/839 (100%), Positives = 839/839 (100%)

Query: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60
           MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
Sbjct: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60

Query: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120
           VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
Sbjct: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120

Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180
           AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180

Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240
           ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240

Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300
           KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300

Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360
           DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360

Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420
           PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420

Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480
           RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480

Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540
           SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540

Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600
           MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600

Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660
           DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660

Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720
           IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720

Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780
           FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780

Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839
           SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839


>gi|74315348 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score = 1689 bits (4375), Expect = 0.0
 Identities = 839/839 (100%), Positives = 839/839 (100%)

Query: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60
           MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
Sbjct: 1   MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP 60

Query: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120
           VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
Sbjct: 61  VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE 120

Query: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180
           AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
Sbjct: 121 AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI 180

Query: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240
           ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
Sbjct: 181 ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT 240

Query: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300
           KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
Sbjct: 241 KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA 300

Query: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360
           DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
Sbjct: 301 DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE 360

Query: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420
           PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
Sbjct: 361 PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN 420

Query: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480
           RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
Sbjct: 421 RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL 480

Query: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540
           SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
Sbjct: 481 SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS 540

Query: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600
           MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
Sbjct: 541 MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE 600

Query: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660
           DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
Sbjct: 601 DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF 660

Query: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720
           IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
Sbjct: 661 IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA 720

Query: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780
           FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
Sbjct: 721 FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS 780

Query: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839
           SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
Sbjct: 781 SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK 839


>gi|22547184 transient receptor potential cation channel, subfamily
           V, member 4 isoform a [Homo sapiens]
          Length = 871

 Score =  685 bits (1768), Expect = 0.0
 Identities = 352/708 (49%), Positives = 498/708 (70%), Gaps = 16/708 (2%)

Query: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169
           L++++R  +F+ V++ +  DL+ LL FL   KK LTD EF++P TGKTCL KA+LNL +G
Sbjct: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205

Query: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229
           +N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR    V LLV  GADV 
Sbjct: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265

Query: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289
           A A G FF+       FYFGELPLSLAACTNQ  IV +L +N  + AD+  +DS GNTVL
Sbjct: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325

Query: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349
           HALV +ADNT +NTKFVT MY+ +L+  A+L P   LE + N  G++PL +AA TGKIG+
Sbjct: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGI 385

Query: 350 LAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETP 408
             +I++RE+ + + RHLSRKF +WAYGPV+SSLYDLS +DTC E+ SVLE++ Y +S+  
Sbjct: 386 FQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILVY-NSKIE 444

Query: 409 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEK 468
           NRH+ML VEP+N LL+DKW +F    FY N + Y   M+IFT+ AYY+P++G PP+    
Sbjct: 445 NRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRT 504

Query: 469 TGDYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATV 527
           T DY R+ GE++++  GV FFF  I+  F+++ P + +LF+D   ++L+F+ S+ ++ + 
Sbjct: 505 TVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSA 564

Query: 528 VLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVF 587
            LY + ++ Y+A MVF+L LGW N LY+TRG +  G Y++MI+K++ +DL RF+ VY++F
Sbjct: 565 ALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLF 624

Query: 588 LFGFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGM 645
           + G+++A+V+L+    N  + +E  ++      P+CR  DS   S +   L+LFK TIGM
Sbjct: 625 MIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCR--DSETFSTF--LLDLFKLTIGM 680

Query: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705
           GDLE   +  +  VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A T
Sbjct: 681 GDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATT 740

Query: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765
           ILD E+SF   +RKAFRSG+++ VG + DG  D RWCFRVDEVNW+ WN N+GIINEDPG
Sbjct: 741 ILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPG 800

Query: 766 NCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813
             E   +   FS    R+    W   ++VP + E +    +++ P+EV
Sbjct: 801 KNE-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 841


>gi|20127551 transient receptor potential cation channel, subfamily
           V, member 2 [Homo sapiens]
          Length = 764

 Score =  631 bits (1627), Expect = 0.0
 Identities = 343/697 (49%), Positives = 464/697 (66%), Gaps = 19/697 (2%)

Query: 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172
           +DR  +F AV++   +DL  L  +L K+ K+LTD+E+ +  TGKTCL+KA+LNL DG N 
Sbjct: 74  FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 133

Query: 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232
            I  LL+I R + + + LVNA  TD YY+G +ALHIAIE+R++  V LLVENGA+V A A
Sbjct: 134 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 193

Query: 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292
            G FF+K +G   FYFGELPLSLAACT Q  +V +LL+N  Q A + A DS GNTVLHAL
Sbjct: 194 CGRFFQKGQGTC-FYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 252

Query: 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352
           V ++DN+A+N   VTSMY+ +L  GA+L PT++LE++ N + +TPL LAA  GKI +  +
Sbjct: 253 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 312

Query: 353 ILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHD 412
           ILQRE       HLSRKFTEW YGPV  SLYDL+ +D+CE+NSVLE+IA+   ++P+RH 
Sbjct: 313 ILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC-KSPHRHR 369

Query: 413 MLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV---DGLPPFKMEKT 469
           M+++EPLN+LLQ KWD  + + F+ NFL   +YM IFT  AY++P       P  K E  
Sbjct: 370 MVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAE-V 427

Query: 470 GDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529
           G+   +TG IL +LGG+Y     + YF +R   +   F+DSY E+LF  Q+L  + + VL
Sbjct: 428 GNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVL 487

Query: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589
            F  ++ Y+  +V +L LGW N+LYYTRGFQ  GIY+VMI+K+ILRDL RF+ +Y+VFLF
Sbjct: 488 CFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF 547

Query: 590 GFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPD----SSYNSLYSTCLELFKFTIGM 645
           GF+ A+V+L ++      P+   +     P     D    + Y  +    LELFKFTIGM
Sbjct: 548 GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGM 607

Query: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705
           G+L F E   F+ + ++LLLAYV+LTYILLLNMLIALM ETVN +A +S +IWKLQ+AI+
Sbjct: 608 GELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAIS 667

Query: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765
           +L+ E  +  C RK  R+G +L VG  PDG  D RWCFRV+EVNW +W   +  + EDP 
Sbjct: 668 VLEMENGYWWC-RKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPS 726

Query: 766 NCEGVKRTLSFSLRSS----RVSGRHWKNFALVPLLR 798
              GV RTL   + +S       G   +N+  V LL+
Sbjct: 727 GA-GVPRTLENPVLASPPKEDEDGASEENYVPVQLLQ 762


>gi|21735483 transient receptor potential cation channel, subfamily
           V, member 3 [Homo sapiens]
          Length = 790

 Score =  543 bits (1398), Expect = e-154
 Identities = 295/663 (44%), Positives = 414/663 (62%), Gaps = 40/663 (6%)

Query: 115 RRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKD--------PETGKTCLLKAMLNL 166
           ++ IF AV++   ++L  LL+ LQ+  +   D +  D         +TGKTCL+KA+LN+
Sbjct: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179

Query: 167 HDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGA 226
           +      + +LL  A + D L   +NA YT+  Y+GQTAL+IAIERR   +  LL+  GA
Sbjct: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239

Query: 227 DVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGN 286
           DV A A G FF       GFYFGE PL+LAACTNQ  IV+ L+++  +  DI++RDS GN
Sbjct: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEH--EQTDITSRDSRGN 297

Query: 287 TVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
            +LHALV VA++      FV  MY+ IL+         +LE   N  G+TPL LAA  GK
Sbjct: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353

Query: 347 IGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSE 406
             +L YIL REI+E   R LSRKFT+WAYGPV SSLYDL+ +DT   NSVLE+  Y+++ 
Sbjct: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTN- 412

Query: 407 TPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRP--VDGLP-P 463
             NRH+ML +EPL+ LL  KW +F K +F+ +F  Y  Y I  T+ +YYRP   + +P P
Sbjct: 413 IDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHP 472

Query: 464 FKMEKTGDYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSMKTLFVDSYSEMLFFLQSLF 522
             +     + ++ G +  ++  +    + GI  FL R   ++++  D++   +FF+Q++ 
Sbjct: 473 LALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVL 532

Query: 523 MLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMF 582
           ++ +V LY    KEY+A +V ++ALGW NMLYYTRGFQ MG+Y+VMI+K+IL D+ +F+F
Sbjct: 533 VILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLF 592

Query: 583 VYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFT 642
           VYIVFL GF  A+ +LIE    D+                   SSY S     LELFK T
Sbjct: 593 VYIVFLLGFGVALASLIEKCPKDNKDC----------------SSYGSFSDAVLELFKLT 636

Query: 643 IGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQR 702
           IG+GDL   +N  +  +F+ LL+ YVILT++LLLNMLIALMGETV  +++ES+ IW+LQR
Sbjct: 637 IGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQR 696

Query: 703 AITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINE 762
           A TIL+ EK   + +R  FR G+L +V      +DD+R C R++EV WT W T+V  +NE
Sbjct: 697 ARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHVSFLNE 751

Query: 763 DPG 765
           DPG
Sbjct: 752 DPG 754


>gi|22547180 transient receptor potential cation channel, subfamily
           V, member 4 isoform b [Homo sapiens]
          Length = 811

 Score =  372 bits (954), Expect = e-102
 Identities = 214/586 (36%), Positives = 336/586 (57%), Gaps = 69/586 (11%)

Query: 286 NTVLHALVEVADNTADNTKFVTSMYNEI-----------------------LMLGAKLHP 322
           N  +  L+++A+ T +  +F+ S + +I                       +  GA +H 
Sbjct: 207 NDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHA 266

Query: 323 TLKLEELTNKK-------GMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY 375
             +      K        G  PL+LAA T +  ++ Y+ +   ++ + R    +     +
Sbjct: 267 QARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLH 326

Query: 376 GPVH------------SSLYDLSCIDTCE--KNSVLEVIAYSSSETP-----------NR 410
             V             + +YDL  +       +S LE +  +   +P           NR
Sbjct: 327 ALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNR 386

Query: 411 HDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG 470
           H+ML VEP+N LL+DKW +F    FY N + Y   M+IFT+ AYY+P++G PP+    T 
Sbjct: 387 HEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTV 446

Query: 471 DYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529
           DY R+ GE++++  GV FFF  I+  F+++ P + +LF+D   ++L+F+ S+ ++ +  L
Sbjct: 447 DYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAAL 506

Query: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589
           Y + ++ Y+A MVF+L LGW N LY+TRG +  G Y++MI+K++ +DL RF+ VY++F+ 
Sbjct: 507 YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMI 566

Query: 590 GFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGMGD 647
           G+++A+V+L+    N  + +E  ++      P+CR  ++    L    L+LFK TIGMGD
Sbjct: 567 GYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFL----LDLFKLTIGMGD 622

Query: 648 LEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITIL 707
           LE   +  +  VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A TIL
Sbjct: 623 LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTIL 682

Query: 708 DTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNC 767
           D E+SF   +RKAFRSG+++ VG + DG  D RWCFRVDEVNW+ WN N+GIINEDPG  
Sbjct: 683 DIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKN 742

Query: 768 EGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813
           E   +   FS    R+    W   ++VP + E +    +++ P+EV
Sbjct: 743 E-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 781



 Score =  256 bits (653), Expect = 8e-68
 Identities = 137/261 (52%), Positives = 179/261 (68%)

Query: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169
           L++++R  +F+ V++ +  DL+ LL FL   KK LTD EF++P TGKTCL KA+LNL +G
Sbjct: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205

Query: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229
           +N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR    V LLV  GADV 
Sbjct: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265

Query: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289
           A A G FF+       FYFGELPLSLAACTNQ  IV +L +N  + AD+  +DS GNTVL
Sbjct: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325

Query: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349
           HALV +ADNT +NTKFVT MY+ +L+  A+L P   LE + N  G++PL +AA TGKIG 
Sbjct: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGN 385

Query: 350 LAYILQREIQEPECRHLSRKF 370
              +L  E      R   RKF
Sbjct: 386 RHEMLAVEPINELLRDKWRKF 406


>gi|21314682 transient receptor potential cation channel, subfamily
           V, member 6 [Homo sapiens]
          Length = 725

 Score =  242 bits (618), Expect = 9e-64
 Identities = 177/562 (31%), Positives = 274/562 (48%), Gaps = 78/562 (13%)

Query: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244
           ++  ELV    T   Y+GQTALHIA+  +NM LV  L+   A V A A G  F+++    
Sbjct: 100 EAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNL 159

Query: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304
             YFGE PLS AAC N   IV+ L+++    ADI A+DS+GNTVLH L+        N  
Sbjct: 160 -IYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210

Query: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364
           F   MYN +L           L+ + N +G+TP  LA   G   +  +++Q+        
Sbjct: 211 FACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262

Query: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423
              RK T+W YGP+ S+LYDL+ ID+  ++ S+LE+I   +++      +L   P+  L+
Sbjct: 263 ---RKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELII--TTKKREARQILDQTPVKELV 317

Query: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG------------- 470
             KW R+ +  F     +Y LY+I FTM   YRP   L P    +T              
Sbjct: 318 SLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRP---LKPRTNNRTSPRDNTLLQQKLLQ 374

Query: 471 -------DYFRVTGEILSVLGGVYF--------FFRGIQYFLQRRPSMKTLFVDSYSEML 515
                  D  R+ GE+++V+G +          F  G+  F  +        +     +L
Sbjct: 375 EAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQT------ILGGPFHVL 428

Query: 516 FFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILR 575
               +  +L T+V+        V  M F+L LGW N++Y+ RGFQ +G + +MI+KMI  
Sbjct: 429 IITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFG 488

Query: 576 DLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTC 635
           DL RF ++  V + GF++A   + +     +   E   H +  P          +L+ST 
Sbjct: 489 DLMRFCWLMAVVILGFASAFYIIFQ-----TEDPEELGHFYDYPM---------ALFST- 533

Query: 636 LELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESK 695
            ELF  TI  G   +  N D   ++ I   A+ I+  +L+LN+LIA+MG+T  ++A E  
Sbjct: 534 FELF-LTIIDGPANY--NVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERD 590

Query: 696 NIWKLQRAITILDTEKSFLKCM 717
            +W+ Q   T +  E+   +C+
Sbjct: 591 ELWRAQIVATTVMLERKLPRCL 612


>gi|17505200 transient receptor potential cation channel, subfamily
           V, member 5 [Homo sapiens]
          Length = 729

 Score =  240 bits (613), Expect = 3e-63
 Identities = 173/554 (31%), Positives = 267/554 (48%), Gaps = 62/554 (11%)

Query: 185 DSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRP 244
           ++  ELV    T   + GQTALHIA+  +N+ LV  L+   A V A A G  F+++  R 
Sbjct: 100 EAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSP-RN 158

Query: 245 GFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTK 304
             YFGE PLS AAC N   IV+ L+++    ADI A+DS+GNTVLH L+        N  
Sbjct: 159 LIYFGEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKT 210

Query: 305 FVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECR 364
           F   MYN +L           L+ + N +G+TP  LA   G   +  +++Q+        
Sbjct: 211 FACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK-------- 262

Query: 365 HLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDMLLVEPLNRLL 423
              R+  +W YGP+ S LYDL+ ID+  E+ S LE++   SS+      +L   P+  L+
Sbjct: 263 ---RRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVV--SSDKREARQILEQTPVKELV 317

Query: 424 QDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-----------------DGLPPFKM 466
             KW+++ +  F     +Y LYMI FT    YRP+                   L     
Sbjct: 318 SFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAY 377

Query: 467 EKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSM---KTLFVDSYSEMLFFLQSLFM 523
           E   D  R+ GE++S++G V      I    +   S    KT+    +  ++    SL +
Sbjct: 378 ETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASL-V 436

Query: 524 LATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFV 583
           L T+V+  ++    V  M F+L LGW +++Y+TRGFQ +G + +MI+KMI  DL RF ++
Sbjct: 437 LVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWL 496

Query: 584 YIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTI 643
             V + GF++A   + +                  P        Y     T  ELF   I
Sbjct: 497 MAVVILGFASAFYIIFQT---------------EDPTSLGQFYDYPMALFTTFELFLTVI 541

Query: 644 GMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRA 703
              D     + D   +F I+  A+ I+  +L+LN+ IA+MG+T  ++AQE   +W+ Q  
Sbjct: 542 ---DAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVV 598

Query: 704 ITILDTEKSFLKCM 717
            T +  E+   +C+
Sbjct: 599 ATTVMLERKLPRCL 612


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 52/164 (31%), Positives = 75/164 (45%), Gaps = 33/164 (20%)

Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252
           AS   +  +G+TALH+A       +V  LV++GA V+A A  D              + P
Sbjct: 457 ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD--------------QTP 502

Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNE 312
           L ++A   +  IV+ LLQ   Q A  +A  + G T LH  +   +   D   F       
Sbjct: 503 LHISARLGKADIVQQLLQ---QGASPNAATTSGYTPLH--LSAREGHEDVAAF------- 550

Query: 313 ILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           +L  GA L        +T KKG TPL +AA  GK+ V   +LQ+
Sbjct: 551 LLDHGASL-------SITTKKGFTPLHVAAKYGKLEVANLLLQK 587



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 51/169 (30%), Positives = 71/169 (42%), Gaps = 30/169 (17%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V +LV NGA+V A +   F               PL +AA  N
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF--------------TPLYMAAQEN 151

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEI----LML 316
            L +VKFLL N    A  S     G T L   ++   +   +         ++    L +
Sbjct: 152 HLEVVKFLLDNG---ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHI 208

Query: 317 GAKLHPT----LKLE-----ELTNKKGMTPLALAAGTGKIGVLAYILQR 356
            A+   T    L L+     ++ +K G TPL +AA  G I V   +L R
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 49/180 (27%), Positives = 69/180 (38%), Gaps = 38/180 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAA--------------AHGDFFKKTKGRPGFY 247
           G T LHIA ++  M + T L+E GAD  A                H D      GR    
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690

Query: 248 -----FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADN 302
                 G  PL LAA  +++ + + L+    Q A + A+  +G T LH            
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVN---QGAHVDAQTKMGYTPLH------------ 735

Query: 303 TKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPE 362
              V   Y  I ++   L  + K+   T K G TPL  AA  G   ++  +LQ      E
Sbjct: 736 ---VGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 49/178 (27%), Positives = 72/178 (40%), Gaps = 40/178 (22%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N  +  LL++ GA   AAA                G  PL +AA  NQ
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN--------------GYTPLHIAAKKNQ 643

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
           + I   LL+     AD +A    G   +H   +  +   D            L+LG   +
Sbjct: 644 MDIATTLLEYG---ADANAVTRQGIASVHLAAQ--EGHVDMVS---------LLLGRNAN 689

Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVH 379
                  L+NK G+TPL LAA   ++ V       E+   +  H+  + T+  Y P+H
Sbjct: 690 -----VNLSNKSGLTPLHLAAQEDRVNV------AEVLVNQGAHVDAQ-TKMGYTPLH 735



 Score = 37.7 bits (86), Expect = 0.045
 Identities = 32/99 (32%), Positives = 45/99 (45%), Gaps = 17/99 (17%)

Query: 192 NASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGEL 251
           NA+   S   G T LH+A +   + +  +LV  GA V A        +TK       G  
Sbjct: 687 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA--------QTK------MGYT 732

Query: 252 PLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH 290
           PL +      + IV FLLQ+S   A ++A+   G T LH
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHS---AKVNAKTKNGYTPLH 768



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 57/235 (24%), Positives = 79/235 (33%), Gaps = 51/235 (21%)

Query: 142 KHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLE-------------IARQTDSLK 188
           K L DN        +       + L  G +  + LLLE             IA + D  K
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216

Query: 189 E----LVNASYTDSYYK-GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGR 243
                L N +  D   K G T LHIA    N+ + TLL+   A V   A  D        
Sbjct: 217 AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI------- 269

Query: 244 PGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNT 303
                   PL +A+      +VK LL      A I A+   G T LH             
Sbjct: 270 -------TPLHVASKRGNANMVKLLLDRG---AKIDAKTRDGLTPLHCGARSGHEQV--- 316

Query: 304 KFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREI 358
                    + ML  +  P L       K G++PL +A     +  +  +LQ  +
Sbjct: 317 ---------VEMLLDRAAPILS----KTKNGLSPLHMATQGDHLNCVQLLLQHNV 358


>gi|6912736 transient receptor potential cation channel, subfamily
           C, member 5 [Homo sapiens]
          Length = 973

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 35/145 (24%), Positives = 73/145 (50%), Gaps = 8/145 (5%)

Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621
           +G   + + +M+L D+ +F+F+Y + L  F+  +  L    +  ++   +     +G  C
Sbjct: 503 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNC---KGIRC 558

Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677
              ++++++L+ T   LF    G+ +L  T     ++F + V   +   Y +++ ++LLN
Sbjct: 559 EKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLN 618

Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702
           MLIA+M  +   IA  +   WK  R
Sbjct: 619 MLIAMMNNSYQLIADHADIEWKFAR 643


>gi|209863032 transient receptor potential cation channel, subfamily
           C, member 4 isoform zeta [Homo sapiens]
          Length = 804

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%)

Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621
           +G   + + +M+L D+ +F+F+Y + L  F+  +  L           E+     +G  C
Sbjct: 329 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 381

Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677
              ++++++L+ T   LF    G+ +L  T     ++F + V   +   Y +++ ++LLN
Sbjct: 382 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 441

Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702
           MLIA+M  +   IA  +   WK  R
Sbjct: 442 MLIAMMNNSYQLIADHADIEWKFAR 466


>gi|209863030 transient receptor potential cation channel, subfamily
           C, member 4 isoform delta [Homo sapiens]
          Length = 836

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%)

Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621
           +G   + + +M+L D+ +F+F+Y + L  F+  +  L           E+     +G  C
Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554

Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677
              ++++++L+ T   LF    G+ +L  T     ++F + V   +   Y +++ ++LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614

Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702
           MLIA+M  +   IA  +   WK  R
Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639


>gi|209863026 transient receptor potential cation channel, subfamily
           C, member 4 isoform beta [Homo sapiens]
          Length = 893

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%)

Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621
           +G   + + +M+L D+ +F+F+Y + L  F+  +  L           E+     +G  C
Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554

Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677
              ++++++L+ T   LF    G+ +L  T     ++F + V   +   Y +++ ++LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614

Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702
           MLIA+M  +   IA  +   WK  R
Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639


>gi|209863024 transient receptor potential cation channel, subfamily
           C, member 4 isoform epsilon [Homo sapiens]
          Length = 982

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%)

Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621
           +G   + + +M+L D+ +F+F+Y + L  F+  +  L           E+     +G  C
Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554

Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677
              ++++++L+ T   LF    G+ +L  T     ++F + V   +   Y +++ ++LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614

Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702
           MLIA+M  +   IA  +   WK  R
Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639


>gi|7706747 transient receptor potential cation channel, subfamily
           C, member 4 isoform alpha [Homo sapiens]
          Length = 977

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 36/145 (24%), Positives = 71/145 (48%), Gaps = 11/145 (7%)

Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621
           +G   + + +M+L D+ +F+F+Y + L  F+  +  L           E+     +G  C
Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554

Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677
              ++++++L+ T   LF    G+ +L  T     ++F + V   +   Y +++ ++LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614

Query: 678 MLIALMGETVNKIAQESKNIWKLQR 702
           MLIA+M  +   IA  +   WK  R
Sbjct: 615 MLIAMMNNSYQLIADHADIEWKFAR 639


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 81/327 (24%), Positives = 120/327 (36%), Gaps = 61/327 (18%)

Query: 130 LESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKE 189
           L+  +  L +     TD  FK   +G    ++ +L+  D    T+  +       D  ++
Sbjct: 383 LKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEK 442

Query: 190 LVNASYTDSYY--------KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTK 241
           LV+    D           +G T LH+A      +L+ LLV  GA V A           
Sbjct: 443 LVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATD--------- 493

Query: 242 GRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301
                Y G  PL LA C      V  LL +   +A++  +D+ GNT LH          D
Sbjct: 494 -----YHGATPLHLA-CQKGYQSVTLLLLHYKASAEV--QDNNGNTPLHLACTYGHE--D 543

Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR----E 357
             K +     E   L           ++ N+KG TPL +AA  G  GV+  +LQ     E
Sbjct: 544 CVKALVYYDVESCRL-----------DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTE 592

Query: 358 IQE------------------PECRHLS-RKFTEWAYGPVHSSLYDLSCIDTCEKNSVLE 398
           IQ                    E  HLS  +  + +  PV S    +  I      S   
Sbjct: 593 IQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS 652

Query: 399 VIAYSSSETPNRHDMLLVEPLNRLLQD 425
            ++ SS +   + D   VE L R + D
Sbjct: 653 SMSASSRQEETKKDYREVEKLLRAVAD 679



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 17/37 (45%), Positives = 24/37 (64%)

Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229
           AS   S  KG TALH A+  +++ +V LL+ +GA VQ
Sbjct: 834 ASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 69/318 (21%), Positives = 128/318 (40%), Gaps = 70/318 (22%)

Query: 409 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEK 468
           NR ++L        L  KW  +  R    N   YCL +I  T+      V+  P      
Sbjct: 693 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILV----VNIKPGMAFNS 748

Query: 469 TG----------------DYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYS 512
           TG                 Y   T  IL  L  ++ + +      Q++   +  F+D  +
Sbjct: 749 TGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQK---RNYFMDISN 805

Query: 513 EMLFFLQS---LFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMI 569
            + + + +   +F+L   V   +HL+    ++  ++   W N L Y + F+  GI+ VM+
Sbjct: 806 VLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAI--AVYFYWMNFLLYLQRFENCGIFIVML 863

Query: 570 EKMILRDLCR--FMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSS 627
           E +IL+ L R   +F++++  FG S  ++  ++D                     P  S 
Sbjct: 864 E-VILKTLLRSTVVFIFLLLAFGLSFYILLNLQD---------------------PFSSP 901

Query: 628 YNSLYSTCLELFKFTIGMGDLEFTENY---------DFKAVFIILLLAYVILTYILLLNM 678
             S+  T      F++ +GD+ + E++             +    L+++ I   I+L+N+
Sbjct: 902 LLSIIQT------FSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNL 955

Query: 679 LIALMGETVNKIAQESKN 696
           LI L    V  IA+  K+
Sbjct: 956 LIGL---AVGDIAEVQKH 970



 Score = 30.0 bits (66), Expect = 9.3
 Identities = 33/136 (24%), Positives = 57/136 (41%), Gaps = 25/136 (18%)

Query: 248 FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVT 307
           +G  PL  A   NQ+  VKFLL          A  ++ N  + A + +A         V 
Sbjct: 97  YGNTPLHCAVEKNQIESVKFLLSR-------GANPNLRNFNMMAPLHIA---------VQ 140

Query: 308 SMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLS 367
            M NE++ +  + H T+ +  L  + G T + +A  T     L  +L++  +   C    
Sbjct: 141 GMNNEVMKVLLE-HRTIDV-NLEGENGNTAVIIACTTNNSEALQILLKKGAK--PC---- 192

Query: 368 RKFTEWAYGPVHSSLY 383
            K  +W   P+H + +
Sbjct: 193 -KSNKWGCFPIHQAAF 207


>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
          Length = 300

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 34/90 (37%), Positives = 44/90 (48%), Gaps = 17/90 (18%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG+TALH A    N  +V LL+++GAD               R G   G  PL LAACTN
Sbjct: 142 KGRTALHFASCNGNDQIVQLLLDHGAD------------PNQRDG--LGNTPLHLAACTN 187

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLH 290
            + ++  LL+     A + A D  G T LH
Sbjct: 188 HVPVITTLLRGG---ARVDALDRAGRTPLH 214


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 46/156 (29%), Positives = 68/156 (43%), Gaps = 33/156 (21%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           +G+TALH+A     + +V  L+ NGA V A A  +              + PL +A+   
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE--------------QTPLHIASRLG 487

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKL 320
           +  IV+ LLQ+    A   A  + G T LH  +   +   D       + + +L  GA  
Sbjct: 488 KTEIVQLLLQH---MAHPDAATTNGYTPLH--ISAREGQVD-------VASVLLEAGA-- 533

Query: 321 HPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
                   L  KKG TPL +AA  G + V   +LQR
Sbjct: 534 -----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 49/179 (27%), Positives = 72/179 (40%), Gaps = 42/179 (23%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V +LV+ GA++ A +   F               PL +AA  N
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 120

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA------DNTKFVTSMYNEIL 314
            + +VK+LL+N    A+ S     G T L   ++   N A      ++TK    +    L
Sbjct: 121 HIDVVKYLLENG---ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL--PAL 175

Query: 315 MLGAKLHPTLKLEEL-----------------TNKKGMTPLALAAGTGKIGVLAYILQR 356
            + A+   T     L                 T + G TPL +AA  G + V   +L R
Sbjct: 176 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 43/148 (29%), Positives = 59/148 (39%), Gaps = 33/148 (22%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N  +  LL+E GA   A A                G  PL +AA  NQ
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--------------GYTPLHIAAKKNQ 620

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
           + I   LL    +T  ++ +   G T LH   +            T M   +L  GA +H
Sbjct: 621 MQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGH---------TDMVTLLLDKGANIH 668

Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGV 349
                  ++ K G+T L LAA   K+ V
Sbjct: 669 -------MSTKSGLTSLHLAAQEDKVNV 689



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 48/171 (28%), Positives = 72/171 (42%), Gaps = 34/171 (19%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LHIA ++  + ++ LLV+ GA +QA                  G  P+ +AA    
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITES--------------GLTPIHVAAFMGH 422

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLH-----ALVEVADNTADNTKFVTSMYNE---I 313
           L IV  LLQN    A     +  G T LH       VEV      N   V +   E    
Sbjct: 423 LNIVLLLLQNG---ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 479

Query: 314 LMLGAKLHPT----LKLEELTN-----KKGMTPLALAAGTGKIGVLAYILQ 355
           L + ++L  T    L L+ + +       G TPL ++A  G++ V + +L+
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 43/169 (25%), Positives = 67/169 (39%), Gaps = 38/169 (22%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAH-----------------GDFFKKTKGR 243
           +G T LH+A +  +  +VTLL++ GA++  +                    D   K    
Sbjct: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699

Query: 244 PGFY--FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301
              +   G  PL +A     + +V FLL+   Q A+++A+   G T LH   +       
Sbjct: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLK---QGANVNAKTKNGYTPLHQAAQQGH---- 752

Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
                T + N +L  GAK          T   G T LA+A   G I V+
Sbjct: 753 -----THIINVLLQHGAK-------PNATTANGNTALAIAKRLGYISVV 789



 Score = 37.7 bits (86), Expect = 0.045
 Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 40/214 (18%)

Query: 144 LTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQ 203
           L +N+ K    GK  L    +        +  LLL+     D   +++    T+S   G 
Sbjct: 161 LLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES---GF 213

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LHIA    N+ + TLL+  GA V   A                G  PL +A+      
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARN--------------GITPLHVASKRGNTN 259

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323
           +VK LL    Q   I A+   G T LH       +          +   +L  GA L   
Sbjct: 260 MVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHD---------QVVELLLERGAPL--- 304

Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357
                   K G++PL +AA    +  + ++LQ +
Sbjct: 305 ----LARTKNGLSPLHMAAQGDHVECVKHLLQHK 334



 Score = 37.4 bits (85), Expect = 0.058
 Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 33/156 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G  ALH+A +  ++ LV  L+  G+ V +A      KK         G   L +A+   Q
Sbjct: 43  GLNALHLAAKEGHVGLVQELLGRGSSVDSAT-----KK---------GNTALHIASLAGQ 88

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
             +VK L++     A+I+A+   G T L+   +  +N  D  K+       +L  GA   
Sbjct: 89  AEVVKVLVKEG---ANINAQSQNGFTPLYMAAQ--ENHIDVVKY-------LLENGAN-- 134

Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357
                +    + G TPLA+A   G    +A +L+ +
Sbjct: 135 -----QSTATEDGFTPLAVALQQGHNQAVAILLEND 165



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 47/181 (25%), Positives = 66/181 (36%), Gaps = 52/181 (28%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LHI+     + + ++L+E GA     AH    KK         G  PL +AA    
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGA-----AHSLATKK---------GFTPLHVAAKYGS 554

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
           L + K LLQ        +A DS G   L  L   A    DN K    +  +    GA  H
Sbjct: 555 LDVAKLLLQRR------AAADSAGKNGLTPLHVAAHY--DNQKVALLLLEK----GASPH 602

Query: 322 PTLKL--------------------------EELTNKKGMTPLALAAGTGKIGVLAYILQ 355
            T K                             +  K+G+TPL LA+  G   ++  +L 
Sbjct: 603 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662

Query: 356 R 356
           +
Sbjct: 663 K 663



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 36/152 (23%), Positives = 64/152 (42%), Gaps = 33/152 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           TALH+A    +  +  LL++  A+  A A   F               PL +A   N++ 
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF--------------TPLHIACKKNRIK 391

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323
           +++ L++     A I A    G T +H              F+  +   +L+L     P 
Sbjct: 392 VMELLVKYG---ASIQAITESGLTPIHV-----------AAFMGHLNIVLLLLQNGASP- 436

Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQ 355
               ++TN +G T L +AA  G++ V+  +L+
Sbjct: 437 ----DVTNIRGETALHMAARAGQVEVVRCLLR 464


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 46/156 (29%), Positives = 68/156 (43%), Gaps = 33/156 (21%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           +G+TALH+A     + +V  L+ NGA V A A  +              + PL +A+   
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE--------------QTPLHIASRLG 508

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKL 320
           +  IV+ LLQ+    A   A  + G T LH  +   +   D       + + +L  GA  
Sbjct: 509 KTEIVQLLLQH---MAHPDAATTNGYTPLH--ISAREGQVD-------VASVLLEAGA-- 554

Query: 321 HPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
                   L  KKG TPL +AA  G + V   +LQR
Sbjct: 555 -----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 49/179 (27%), Positives = 72/179 (40%), Gaps = 42/179 (23%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V +LV+ GA++ A +   F               PL +AA  N
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 141

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA------DNTKFVTSMYNEIL 314
            + +VK+LL+N    A+ S     G T L   ++   N A      ++TK    +    L
Sbjct: 142 HIDVVKYLLENG---ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL--PAL 196

Query: 315 MLGAKLHPTLKLEEL-----------------TNKKGMTPLALAAGTGKIGVLAYILQR 356
            + A+   T     L                 T + G TPL +AA  G + V   +L R
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 43/148 (29%), Positives = 59/148 (39%), Gaps = 33/148 (22%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N  +  LL+E GA   A A                G  PL +AA  NQ
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--------------GYTPLHIAAKKNQ 641

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
           + I   LL    +T  ++ +   G T LH   +            T M   +L  GA +H
Sbjct: 642 MQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGH---------TDMVTLLLDKGANIH 689

Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGV 349
                  ++ K G+T L LAA   K+ V
Sbjct: 690 -------MSTKSGLTSLHLAAQEDKVNV 710



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 48/171 (28%), Positives = 72/171 (42%), Gaps = 34/171 (19%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LHIA ++  + ++ LLV+ GA +QA                  G  P+ +AA    
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITES--------------GLTPIHVAAFMGH 443

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLH-----ALVEVADNTADNTKFVTSMYNE---I 313
           L IV  LLQN    A     +  G T LH       VEV      N   V +   E    
Sbjct: 444 LNIVLLLLQNG---ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500

Query: 314 LMLGAKLHPT----LKLEELTN-----KKGMTPLALAAGTGKIGVLAYILQ 355
           L + ++L  T    L L+ + +       G TPL ++A  G++ V + +L+
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 43/169 (25%), Positives = 67/169 (39%), Gaps = 38/169 (22%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAH-----------------GDFFKKTKGR 243
           +G T LH+A +  +  +VTLL++ GA++  +                    D   K    
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720

Query: 244 PGFY--FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301
              +   G  PL +A     + +V FLL+   Q A+++A+   G T LH   +       
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLK---QGANVNAKTKNGYTPLHQAAQQGH---- 773

Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
                T + N +L  GAK          T   G T LA+A   G I V+
Sbjct: 774 -----THIINVLLQHGAK-------PNATTANGNTALAIAKRLGYISVV 810



 Score = 37.7 bits (86), Expect = 0.045
 Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 40/214 (18%)

Query: 144 LTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQ 203
           L +N+ K    GK  L    +        +  LLL+     D   +++    T+S   G 
Sbjct: 182 LLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES---GF 234

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LHIA    N+ + TLL+  GA V   A                G  PL +A+      
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARN--------------GITPLHVASKRGNTN 280

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323
           +VK LL    Q   I A+   G T LH       +          +   +L  GA L   
Sbjct: 281 MVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHD---------QVVELLLERGAPL--- 325

Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357
                   K G++PL +AA    +  + ++LQ +
Sbjct: 326 ----LARTKNGLSPLHMAAQGDHVECVKHLLQHK 355



 Score = 37.4 bits (85), Expect = 0.058
 Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 33/156 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G  ALH+A +  ++ LV  L+  G+ V +A      KK         G   L +A+   Q
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSAT-----KK---------GNTALHIASLAGQ 109

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
             +VK L++     A+I+A+   G T L+   +  +N  D  K+       +L  GA   
Sbjct: 110 AEVVKVLVKEG---ANINAQSQNGFTPLYMAAQ--ENHIDVVKY-------LLENGAN-- 155

Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357
                +    + G TPLA+A   G    +A +L+ +
Sbjct: 156 -----QSTATEDGFTPLAVALQQGHNQAVAILLEND 186



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 47/181 (25%), Positives = 66/181 (36%), Gaps = 52/181 (28%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LHI+     + + ++L+E GA     AH    KK         G  PL +AA    
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGA-----AHSLATKK---------GFTPLHVAAKYGS 575

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
           L + K LLQ        +A DS G   L  L   A    DN K    +  +    GA  H
Sbjct: 576 LDVAKLLLQRR------AAADSAGKNGLTPLHVAAHY--DNQKVALLLLEK----GASPH 623

Query: 322 PTLKL--------------------------EELTNKKGMTPLALAAGTGKIGVLAYILQ 355
            T K                             +  K+G+TPL LA+  G   ++  +L 
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683

Query: 356 R 356
           +
Sbjct: 684 K 684



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 36/152 (23%), Positives = 64/152 (42%), Gaps = 33/152 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           TALH+A    +  +  LL++  A+  A A   F               PL +A   N++ 
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF--------------TPLHIACKKNRIK 412

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323
           +++ L++     A I A    G T +H              F+  +   +L+L     P 
Sbjct: 413 VMELLVKYG---ASIQAITESGLTPIHV-----------AAFMGHLNIVLLLLQNGASP- 457

Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQ 355
               ++TN +G T L +AA  G++ V+  +L+
Sbjct: 458 ----DVTNIRGETALHMAARAGQVEVVRCLLR 485


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 46/156 (29%), Positives = 68/156 (43%), Gaps = 33/156 (21%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           +G+TALH+A     + +V  L+ NGA V A A  +              + PL +A+   
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE--------------QTPLHIASRLG 508

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKL 320
           +  IV+ LLQ+    A   A  + G T LH  +   +   D       + + +L  GA  
Sbjct: 509 KTEIVQLLLQH---MAHPDAATTNGYTPLH--ISAREGQVD-------VASVLLEAGA-- 554

Query: 321 HPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
                   L  KKG TPL +AA  G + V   +LQR
Sbjct: 555 -----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 49/179 (27%), Positives = 72/179 (40%), Gaps = 42/179 (23%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V +LV+ GA++ A +   F               PL +AA  N
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 141

Query: 261 QLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA------DNTKFVTSMYNEIL 314
            + +VK+LL+N    A+ S     G T L   ++   N A      ++TK    +    L
Sbjct: 142 HIDVVKYLLENG---ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL--PAL 196

Query: 315 MLGAKLHPTLKLEEL-----------------TNKKGMTPLALAAGTGKIGVLAYILQR 356
            + A+   T     L                 T + G TPL +AA  G + V   +L R
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 43/148 (29%), Positives = 59/148 (39%), Gaps = 33/148 (22%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N  +  LL+E GA   A A                G  PL +AA  NQ
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--------------GYTPLHIAAKKNQ 641

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
           + I   LL    +T  ++ +   G T LH   +            T M   +L  GA +H
Sbjct: 642 MQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGH---------TDMVTLLLDKGANIH 689

Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGV 349
                  ++ K G+T L LAA   K+ V
Sbjct: 690 -------MSTKSGLTSLHLAAQEDKVNV 710



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 48/171 (28%), Positives = 72/171 (42%), Gaps = 34/171 (19%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LHIA ++  + ++ LLV+ GA +QA                  G  P+ +AA    
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITES--------------GLTPIHVAAFMGH 443

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLH-----ALVEVADNTADNTKFVTSMYNE---I 313
           L IV  LLQN    A     +  G T LH       VEV      N   V +   E    
Sbjct: 444 LNIVLLLLQNG---ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 500

Query: 314 LMLGAKLHPT----LKLEELTN-----KKGMTPLALAAGTGKIGVLAYILQ 355
           L + ++L  T    L L+ + +       G TPL ++A  G++ V + +L+
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 43/169 (25%), Positives = 67/169 (39%), Gaps = 38/169 (22%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAH-----------------GDFFKKTKGR 243
           +G T LH+A +  +  +VTLL++ GA++  +                    D   K    
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720

Query: 244 PGFY--FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTAD 301
              +   G  PL +A     + +V FLL+   Q A+++A+   G T LH   +       
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLK---QGANVNAKTKNGYTPLHQAAQQGH---- 773

Query: 302 NTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
                T + N +L  GAK          T   G T LA+A   G I V+
Sbjct: 774 -----THIINVLLQHGAK-------PNATTANGNTALAIAKRLGYISVV 810



 Score = 37.7 bits (86), Expect = 0.045
 Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 40/214 (18%)

Query: 144 LTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQ 203
           L +N+ K    GK  L    +        +  LLL+     D   +++    T+S   G 
Sbjct: 182 LLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES---GF 234

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LHIA    N+ + TLL+  GA V   A                G  PL +A+      
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARN--------------GITPLHVASKRGNTN 280

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323
           +VK LL    Q   I A+   G T LH       +          +   +L  GA L   
Sbjct: 281 MVKLLLDRGGQ---IDAKTRDGLTPLHCAARSGHD---------QVVELLLERGAPL--- 325

Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357
                   K G++PL +AA    +  + ++LQ +
Sbjct: 326 ----LARTKNGLSPLHMAAQGDHVECVKHLLQHK 355



 Score = 37.4 bits (85), Expect = 0.058
 Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 33/156 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G  ALH+A +  ++ LV  L+  G+ V +A      KK         G   L +A+   Q
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSAT-----KK---------GNTALHIASLAGQ 109

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
             +VK L++     A+I+A+   G T L+   +  +N  D  K+       +L  GA   
Sbjct: 110 AEVVKVLVKEG---ANINAQSQNGFTPLYMAAQ--ENHIDVVKY-------LLENGAN-- 155

Query: 322 PTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQRE 357
                +    + G TPLA+A   G    +A +L+ +
Sbjct: 156 -----QSTATEDGFTPLAVALQQGHNQAVAILLEND 186



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 47/181 (25%), Positives = 66/181 (36%), Gaps = 52/181 (28%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LHI+     + + ++L+E GA     AH    KK         G  PL +AA    
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGA-----AHSLATKK---------GFTPLHVAAKYGS 575

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLH 321
           L + K LLQ        +A DS G   L  L   A    DN K    +  +    GA  H
Sbjct: 576 LDVAKLLLQRR------AAADSAGKNGLTPLHVAAHY--DNQKVALLLLEK----GASPH 623

Query: 322 PTLKL--------------------------EELTNKKGMTPLALAAGTGKIGVLAYILQ 355
            T K                             +  K+G+TPL LA+  G   ++  +L 
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683

Query: 356 R 356
           +
Sbjct: 684 K 684



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 36/152 (23%), Positives = 64/152 (42%), Gaps = 33/152 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           TALH+A    +  +  LL++  A+  A A   F               PL +A   N++ 
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF--------------TPLHIACKKNRIK 412

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPT 323
           +++ L++     A I A    G T +H              F+  +   +L+L     P 
Sbjct: 413 VMELLVKYG---ASIQAITESGLTPIHV-----------AAFMGHLNIVLLLLQNGASP- 457

Query: 324 LKLEELTNKKGMTPLALAAGTGKIGVLAYILQ 355
               ++TN +G T L +AA  G++ V+  +L+
Sbjct: 458 ----DVTNIRGETALHMAARAGQVEVVRCLLR 485


>gi|4507685 transient receptor potential cation channel, subfamily
           C, member 1 [Homo sapiens]
          Length = 759

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 47/253 (18%), Positives = 106/253 (41%), Gaps = 43/253 (16%)

Query: 479 ILSVLGGVY-----FFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSH 533
           IL ++G ++      ++ G++ FL+          +S +++ F + SL++    +   +H
Sbjct: 394 ILWIIGMIWSDIKRLWYEGLEDFLE----------ESRNQLSFVMNSLYLATFALKVVAH 443

Query: 534 LK-----------EYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMI-----LRDL 577
            K            +  ++V      + N+L Y R F      +++    I     L+D 
Sbjct: 444 NKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDF 503

Query: 578 CRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC-RPPDSSYNSLYSTCL 636
            +F+ ++++ LF F+  +  L + G       +       G  C +  + +++S   TC 
Sbjct: 504 GKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCV-----GIFCEQQSNDTFHSFIGTCF 558

Query: 637 ELFKFTIGMGDLE-FTENYDF-----KAVFIILLLAYVILTYILLLNMLIALMGETVNKI 690
            LF +   +  +  F   + +       V  +++  Y ++  I+L  +L+A++ ++   I
Sbjct: 559 ALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLI 618

Query: 691 AQESKNIWKLQRA 703
           A      WK  RA
Sbjct: 619 ANHEDKEWKFARA 631


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252
           G T LHIA ++ ++ ++ LL++ GA + A         T      + G LP         
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 460

Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296
                        L +AA      + K+LLQN    A ++A+     T LH    +    
Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 517

Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342
                 +N A+     T+ +  + +   + H    L  L          KKG TPL +AA
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577

Query: 343 GTGKIGVLAYILQRE 357
             GK+ V   +L+R+
Sbjct: 578 KYGKVRVAELLLERD 592



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V  LV  GA+V A +   F               PL +AA  N
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 155

Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310
            L +VKFLL+N           +    ++ +    N V H +               +  
Sbjct: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 215

Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           N+     A L       ++ +K G TPL +AA    + V   +L R
Sbjct: 216 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%)

Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252
           AS   S  K +T LH+A    +  +   L++N A V A A  D              + P
Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 506

Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300
           L  AA      +VK LL+N+   A+ +   + G+T LH            AL+E   + A
Sbjct: 507 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563

Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
             TK       V + Y ++    L+L    HP         K G+TPL +A     + ++
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 618

Query: 351 AYILQR 356
             +L R
Sbjct: 619 KLLLPR 624



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A+   N+ +V LL+  G    + A              + G  PL +AA  NQ
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 647

Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311
           + + + LLQ                 ++A++     V   L + A+    N   +T ++ 
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 706

Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363
              ++  + H  +         + + T + G TPL +A+  G I ++ ++LQ +      
Sbjct: 707 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 759

Query: 364 RHLSRKFTEWAYGPVHSS 381
             ++ K T+  Y P+H +
Sbjct: 760 --VNAK-TKLGYSPLHQA 774



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%)

Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237
           +A Q + ++ELVN  A+      KG T L++A +  ++ +V  L+ENGA+   A    F 
Sbjct: 120 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 178

Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291
                         PL++A       +V  L+    +         I+AR+    T    
Sbjct: 179 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225

Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
           L      +V   T      + + Y  + +    L+    +   T + G+TPL +A+  G 
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 284

Query: 347 IGVLAYILQREIQ 359
           + ++  +L R  Q
Sbjct: 285 VIMVRLLLDRGAQ 297



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N+ LV  L+++ ADV A        KTK       G  PL  AA    
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 779

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306
             IV  LL+N     ++S+  +    +   L      +V     D T FV
Sbjct: 780 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 829



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LH A    ++ +  +L+++GA +QA        KTK       G  P+ +AA  + L 
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 352

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305
            V+ LLQ   +  DI+       T LH          A V +      N++         
Sbjct: 353 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409

Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           +    N + ++   L     ++ +T + G+TPL +A+  G + ++  +LQR
Sbjct: 410 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 459


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252
           G T LHIA ++ ++ ++ LL++ GA + A         T      + G LP         
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427

Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296
                        L +AA      + K+LLQN    A ++A+     T LH    +    
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484

Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342
                 +N A+     T+ +  + +   + H    L  L          KKG TPL +AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 343 GTGKIGVLAYILQRE 357
             GK+ V   +L+R+
Sbjct: 545 KYGKVRVAELLLERD 559



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V  LV  GA+V A +   F               PL +AA  N
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122

Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310
            L +VKFLL+N           +    ++ +    N V H +               +  
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           N+     A L       ++ +K G TPL +AA    + V   +L R
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%)

Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252
           AS   S  K +T LH+A    +  +   L++N A V A A  D              + P
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473

Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300
           L  AA      +VK LL+N+   A+ +   + G+T LH            AL+E   + A
Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
             TK       V + Y ++    L+L    HP         K G+TPL +A     + ++
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585

Query: 351 AYILQR 356
             +L R
Sbjct: 586 KLLLPR 591



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A+   N+ +V LL+  G    + A              + G  PL +AA  NQ
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614

Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311
           + + + LLQ                 ++A++     V   L + A+    N   +T ++ 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673

Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363
              ++  + H  +         + + T + G TPL +A+  G I ++ ++LQ +      
Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726

Query: 364 RHLSRKFTEWAYGPVHSS 381
             ++ K T+  Y P+H +
Sbjct: 727 --VNAK-TKLGYSPLHQA 741



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%)

Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237
           +A Q + ++ELVN  A+      KG T L++A +  ++ +V  L+ENGA+   A    F 
Sbjct: 87  LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145

Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291
                         PL++A       +V  L+    +         I+AR+    T    
Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
           L      +V   T      + + Y  + +    L+    +   T + G+TPL +A+  G 
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251

Query: 347 IGVLAYILQREIQ 359
           + ++  +L R  Q
Sbjct: 252 VIMVRLLLDRGAQ 264



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N+ LV  L+++ ADV A        KTK       G  PL  AA    
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306
             IV  LL+N     ++S+  +    +   L      +V     D T FV
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LH A    ++ +  +L+++GA +QA        KTK       G  P+ +AA  + L 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305
            V+ LLQ   +  DI+       T LH          A V +      N++         
Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           +    N + ++   L     ++ +T + G+TPL +A+  G + ++  +LQR
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252
           G T LHIA ++ ++ ++ LL++ GA + A         T      + G LP         
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427

Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296
                        L +AA      + K+LLQN    A ++A+     T LH    +    
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484

Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342
                 +N A+     T+ +  + +   + H    L  L          KKG TPL +AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 343 GTGKIGVLAYILQRE 357
             GK+ V   +L+R+
Sbjct: 545 KYGKVRVAELLLERD 559



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V  LV  GA+V A +   F               PL +AA  N
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122

Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310
            L +VKFLL+N           +    ++ +    N V H +               +  
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           N+     A L       ++ +K G TPL +AA    + V   +L R
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%)

Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252
           AS   S  K +T LH+A    +  +   L++N A V A A  D              + P
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473

Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300
           L  AA      +VK LL+N+   A+ +   + G+T LH            AL+E   + A
Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
             TK       V + Y ++    L+L    HP         K G+TPL +A     + ++
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585

Query: 351 AYILQR 356
             +L R
Sbjct: 586 KLLLPR 591



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A+   N+ +V LL+  G    + A              + G  PL +AA  NQ
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614

Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311
           + + + LLQ                 ++A++     V   L + A+    N   +T ++ 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673

Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363
              ++  + H  +         + + T + G TPL +A+  G I ++ ++LQ +      
Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726

Query: 364 RHLSRKFTEWAYGPVHSS 381
             ++ K T+  Y P+H +
Sbjct: 727 --VNAK-TKLGYSPLHQA 741



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%)

Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237
           +A Q + ++ELVN  A+      KG T L++A +  ++ +V  L+ENGA+   A    F 
Sbjct: 87  LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145

Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291
                         PL++A       +V  L+    +         I+AR+    T    
Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
           L      +V   T      + + Y  + +    L+    +   T + G+TPL +A+  G 
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251

Query: 347 IGVLAYILQREIQ 359
           + ++  +L R  Q
Sbjct: 252 VIMVRLLLDRGAQ 264



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N+ LV  L+++ ADV A        KTK       G  PL  AA    
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306
             IV  LL+N     ++S+  +    +   L      +V     D T FV
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LH A    ++ +  +L+++GA +QA        KTK       G  P+ +AA  + L 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305
            V+ LLQ   +  DI+       T LH          A V +      N++         
Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           +    N + ++   L     ++ +T + G+TPL +A+  G + ++  +LQR
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252
           G T LHIA ++ ++ ++ LL++ GA + A         T      + G LP         
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427

Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296
                        L +AA      + K+LLQN    A ++A+     T LH    +    
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484

Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342
                 +N A+     T+ +  + +   + H    L  L          KKG TPL +AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 343 GTGKIGVLAYILQRE 357
             GK+ V   +L+R+
Sbjct: 545 KYGKVRVAELLLERD 559



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V  LV  GA+V A +   F               PL +AA  N
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122

Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310
            L +VKFLL+N           +    ++ +    N V H +               +  
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           N+     A L       ++ +K G TPL +AA    + V   +L R
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%)

Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252
           AS   S  K +T LH+A    +  +   L++N A V A A  D              + P
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473

Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300
           L  AA      +VK LL+N+   A+ +   + G+T LH            AL+E   + A
Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
             TK       V + Y ++    L+L    HP         K G+TPL +A     + ++
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585

Query: 351 AYILQR 356
             +L R
Sbjct: 586 KLLLPR 591



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A+   N+ +V LL+  G    + A              + G  PL +AA  NQ
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614

Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311
           + + + LLQ                 ++A++     V   L + A+    N   +T ++ 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673

Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363
              ++  + H  +         + + T + G TPL +A+  G I ++ ++LQ +      
Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726

Query: 364 RHLSRKFTEWAYGPVHSS 381
             ++ K T+  Y P+H +
Sbjct: 727 --VNAK-TKLGYSPLHQA 741



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%)

Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237
           +A Q + ++ELVN  A+      KG T L++A +  ++ +V  L+ENGA+   A    F 
Sbjct: 87  LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145

Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291
                         PL++A       +V  L+    +         I+AR+    T    
Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
           L      +V   T      + + Y  + +    L+    +   T + G+TPL +A+  G 
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251

Query: 347 IGVLAYILQREIQ 359
           + ++  +L R  Q
Sbjct: 252 VIMVRLLLDRGAQ 264



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N+ LV  L+++ ADV A        KTK       G  PL  AA    
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306
             IV  LL+N     ++S+  +    +   L      +V     D T FV
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LH A    ++ +  +L+++GA +QA        KTK       G  P+ +AA  + L 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305
            V+ LLQ   +  DI+       T LH          A V +      N++         
Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           +    N + ++   L     ++ +T + G+TPL +A+  G + ++  +LQR
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 45/195 (23%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP--------- 252
           G T LHIA ++ ++ ++ LL++ GA + A         T      + G LP         
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL---TPLHVASFMGHLPIVKNLLQRG 427

Query: 253 -------------LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVA--- 296
                        L +AA      + K+LLQN    A ++A+     T LH    +    
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGHTN 484

Query: 297 ------DNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTN--------KKGMTPLALAA 342
                 +N A+     T+ +  + +   + H    L  L          KKG TPL +AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 343 GTGKIGVLAYILQRE 357
             GK+ V   +L+R+
Sbjct: 545 KYGKVRVAELLLERD 559



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/166 (26%), Positives = 63/166 (37%), Gaps = 24/166 (14%)

Query: 201 KGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTN 260
           KG TALHIA       +V  LV  GA+V A +   F               PL +AA  N
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGF--------------TPLYMAAQEN 122

Query: 261 QLGIVKFLLQN----------SWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMY 310
            L +VKFLL+N           +    ++ +    N V H +               +  
Sbjct: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 182

Query: 311 NEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           N+     A L       ++ +K G TPL +AA    + V   +L R
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 44/186 (23%)

Query: 193 ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELP 252
           AS   S  K +T LH+A    +  +   L++N A V A A  D              + P
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD--------------QTP 473

Query: 253 LSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLH------------ALVEVADNTA 300
           L  AA      +VK LL+N+   A+ +   + G+T LH            AL+E   + A
Sbjct: 474 LHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 301 DNTK------FVTSMYNEI----LMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVL 350
             TK       V + Y ++    L+L    HP         K G+TPL +A     + ++
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA-----AGKNGLTPLHVAVHHNNLDIV 585

Query: 351 AYILQR 356
             +L R
Sbjct: 586 KLLLPR 591



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A+   N+ +V LL+  G    + A              + G  PL +AA  NQ
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA--------------WNGYTPLHIAAKQNQ 614

Query: 262 LGIVKFLLQNSWQT----------ADISARDSVGNTVLHALVEVADNTADNTKFVTSMYN 311
           + + + LLQ                 ++A++     V   L + A+    N   +T ++ 
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH- 673

Query: 312 EILMLGAKLHPTLK--------LEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPEC 363
              ++  + H  +         + + T + G TPL +A+  G I ++ ++LQ +      
Sbjct: 674 ---LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---- 726

Query: 364 RHLSRKFTEWAYGPVHSS 381
             ++ K T+  Y P+H +
Sbjct: 727 --VNAK-TKLGYSPLHQA 741



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 28/193 (14%)

Query: 180 IARQTDSLKELVN--ASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF 237
           +A Q + ++ELVN  A+      KG T L++A +  ++ +V  L+ENGA+   A    F 
Sbjct: 87  LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF- 145

Query: 238 KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQ------TADISARDSVGNTVLHA 291
                         PL++A       +V  L+    +         I+AR+    T    
Sbjct: 146 -------------TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 292 L-----VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGK 346
           L      +V   T      + + Y  + +    L+    +   T + G+TPL +A+  G 
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTPQNGITPLHIASRRGN 251

Query: 347 IGVLAYILQREIQ 359
           + ++  +L R  Q
Sbjct: 252 VIMVRLLLDRGAQ 264



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 19/110 (17%)

Query: 202 GQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQ 261
           G T LH+A    N+ LV  L+++ ADV A        KTK       G  PL  AA    
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNA--------KTK------LGYSPLHQAAQQGH 746

Query: 262 LGIVKFLLQNSWQTADISARDSVGNTVLHAL-----VEVADNTADNTKFV 306
             IV  LL+N     ++S+  +    +   L      +V     D T FV
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV 796



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 36/171 (21%)

Query: 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263
           T LH A    ++ +  +L+++GA +QA        KTK       G  P+ +AA  + L 
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQA--------KTKN------GLSPIHMAAQGDHLD 319

Query: 264 IVKFLLQNSWQTADISARDSVGNTVLH----------ALVEVADNTADNTK--------F 305
            V+ LLQ   +  DI+       T LH          A V +      N++         
Sbjct: 320 CVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 306 VTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQR 356
           +    N + ++   L     ++ +T + G+TPL +A+  G + ++  +LQR
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQR 426


>gi|209863028 transient receptor potential cation channel, subfamily
           C, member 4 isoform gamma [Homo sapiens]
          Length = 828

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 33/137 (24%), Positives = 69/137 (50%), Gaps = 11/137 (8%)

Query: 562 MGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPAC 621
           +G   + + +M+L D+ +F+F+Y + L  F+  +  L           E+     +G  C
Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY------FYYEETKGLTCKGIRC 554

Query: 622 RPPDSSYNSLYSTCLELFKFTIGMGDLEFTE---NYDF-KAVFIILLLAYVILTYILLLN 677
              ++++++L+ T   LF    G+ +L  T     ++F + V   +   Y +++ ++LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614

Query: 678 MLIALMGETVNKIAQES 694
           MLIA+M  +   IA+ +
Sbjct: 615 MLIAMMNNSYQLIARRA 631


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,514,703
Number of Sequences: 37866
Number of extensions: 1400277
Number of successful extensions: 5466
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 4589
Number of HSP's gapped (non-prelim): 740
length of query: 839
length of database: 18,247,518
effective HSP length: 111
effective length of query: 728
effective length of database: 14,044,392
effective search space: 10224317376
effective search space used: 10224317376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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