Search of human proteins with 73747875

Search of human proteins with 73747875

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73747875 proteasome beta 8 subunit isoform E2 proprotein
[Homo sapiens]
         (276 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Hom...   568   e-162
gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo...   473   e-133
gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]         308   4e-84
gi|153791216 proteasome beta 11 subunit [Homo sapiens]                244   5e-65
gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens]       231   7e-61
gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens]       188   5e-48
gi|23110925 proteasome beta 6 subunit [Homo sapiens]                   99   5e-21
gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo...    97   1e-20
gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ...    97   1e-20
gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]         82   5e-16
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]        80   2e-15
gi|22538467 proteasome beta 4 subunit [Homo sapiens]                   55   9e-08
gi|23110942 proteasome alpha 5 subunit [Homo sapiens]                  54   1e-07
gi|22538465 proteasome beta 3 subunit [Homo sapiens]                   52   4e-07
gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]              50   2e-06
gi|4506195 proteasome beta 2 subunit [Homo sapiens]                    50   2e-06
gi|4506193 proteasome beta 1 subunit [Homo sapiens]                    47   2e-05
gi|221219026 pleckstrin homology-like domain, family B, member 1...    31   1.0  
gi|4505881 plasminogen [Homo sapiens]                                  30   2.3  
gi|221219024 pleckstrin homology-like domain, family B, member 1...    30   3.0  
gi|38424073 pleckstrin homology-like domain, family B, member 1 ...    30   3.0  
gi|4502247 armadillo repeat protein [Homo sapiens]                     29   5.1  
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]      28   6.7  
gi|155969697 keratin 6C [Homo sapiens]                                 28   8.7  
gi|5031839 keratin 6A [Homo sapiens]                                   28   8.7  
gi|197313732 pleckstrin homology-like domain, family B, member 2...    28   8.7  
gi|197313730 pleckstrin homology-like domain, family B, member 2...    28   8.7  
gi|197313728 pleckstrin homology-like domain, family B, member 2...    28   8.7  
gi|21955172 pleckstrin homology-like domain, family B, member 2 ...    28   8.7  
gi|9256606 protocadherin beta 12 precursor [Homo sapiens]              28   8.7  

>gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Homo
           sapiens]
          Length = 276

 Score =  568 bits (1463), Expect = e-162
 Identities = 276/276 (100%), Positives = 276/276 (100%)

Query: 1   MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD 60
           MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
Sbjct: 1   MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD 60

Query: 61  GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC 120
           GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
Sbjct: 61  GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC 120

Query: 121 AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG 180
           AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
Sbjct: 121 AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG 180

Query: 181 PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS 240
           PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
Sbjct: 181 PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS 240

Query: 241 YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ 276
           YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
Sbjct: 241 YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ 276


>gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo
           sapiens]
          Length = 272

 Score =  473 bits (1216), Expect = e-133
 Identities = 228/230 (99%), Positives = 230/230 (100%)

Query: 47  GMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKV 106
           G++PTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKV
Sbjct: 43  GLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKV 102

Query: 107 IEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMG 166
           IEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMG
Sbjct: 103 IEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMG 162

Query: 167 LSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYD 226
           LSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYD
Sbjct: 163 LSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYD 222

Query: 227 LGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ 276
           LGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
Sbjct: 223 LGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ 272


>gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]
          Length = 263

 Score =  308 bits (788), Expect = 4e-84
 Identities = 144/205 (70%), Positives = 174/205 (84%)

Query: 67  IEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQY 126
           IEM HGTTTLAFKF+HGVI A DSRA+AG+YI++  V KVIEINPYLLGTM+G AADC +
Sbjct: 54  IEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSF 113

Query: 127 WERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYV 186
           WERLLA++CR+Y LRN ERISV+AASKLL+NM+ QY+GMGLSMG+MICGWDK+GPGLYYV
Sbjct: 114 WERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYV 173

Query: 187 DEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVV 246
           D  G R+SG  FS GSG+ YAYGVMD GY  +L  E+AYDL RRAI  AT+RD+YSGG V
Sbjct: 174 DSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAV 233

Query: 247 NMYHMKEDGWVKVESTDVSDLLHQY 271
           N+YH++EDGW++V S +V+DL  +Y
Sbjct: 234 NLYHVREDGWIRVSSDNVADLHEKY 258


>gi|153791216 proteasome beta 11 subunit [Homo sapiens]
          Length = 300

 Score =  244 bits (624), Expect = 5e-65
 Identities = 130/265 (49%), Positives = 171/265 (64%), Gaps = 27/265 (10%)

Query: 1   MALLDVCG--APRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLG 58
           MAL DVC   +P  Q P   LP AG                   A+PRG  P  F Q  G
Sbjct: 1   MALQDVCKWQSPDTQGPSPHLPRAGGW-----------------AVPRGCDPQTFLQIHG 43

Query: 59  GDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMS 118
                     +AHGTTTLAF+F+HGVIAA D+R+S GSY++     KVI ++ +LLGT S
Sbjct: 44  P--------RLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTS 95

Query: 119 GCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDK 178
           G +ADC  W R+L +E RL  LR G+  SV++A+KLLS MM QYRG+ L + + +CGWD+
Sbjct: 96  GTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDR 155

Query: 179 KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHR 238
            GP L+YV   GTRL G++FS GSG+ YAYGV+D GYR ++S +EAY L R A+A+ATHR
Sbjct: 156 SGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHR 215

Query: 239 DSYSGGVVNMYHMKEDGWVKVESTD 263
           D+YSGG V+++H++E GW  V  +D
Sbjct: 216 DAYSGGSVDLFHVRESGWEHVSRSD 240


>gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens]
          Length = 160

 Score =  231 bits (588), Expect = 7e-61
 Identities = 105/155 (67%), Positives = 130/155 (83%)

Query: 117 MSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGW 176
           M+G AADC +WERLLA++CR+Y LRN ERISV+AASKLL+NM+ QY+GMGLSMG+MICGW
Sbjct: 1   MAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGW 60

Query: 177 DKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYAT 236
           DK+GPGLYYVD  G R+SG  FS GSG+ YAYGVMD GY  +L  E+AYDL RRAI  AT
Sbjct: 61  DKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQAT 120

Query: 237 HRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQY 271
           +RD+YSGG VN+YH++EDGW++V S +V+DL  +Y
Sbjct: 121 YRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKY 155


>gi|222144262 proteasome beta 5 subunit isoform 3 [Homo sapiens]
          Length = 203

 Score =  188 bits (477), Expect = 5e-48
 Identities = 88/115 (76%), Positives = 104/115 (90%)

Query: 67  IEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQY 126
           IEM HGTTTLAFKF+HGVI A DSRA+AG+YI++  V KVIEINPYLLGTM+G AADC +
Sbjct: 54  IEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSF 113

Query: 127 WERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGP 181
           WERLLA++CR+Y LRN ERISV+AASKLL+NM+ QY+GMGLSMG+MICGWDK+GP
Sbjct: 114 WERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGP 168


>gi|23110925 proteasome beta 6 subunit [Homo sapiens]
          Length = 239

 Score = 98.6 bits (244), Expect = 5e-21
 Identities = 62/189 (32%), Positives = 95/189 (50%), Gaps = 2/189 (1%)

Query: 68  EMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYW 127
           E++ GTT +A +F  GV+   DSR + GSYI+    +K+  I+  +    SG AAD Q  
Sbjct: 30  EVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAV 89

Query: 128 ERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWD-KKGPGLYYV 186
              +  +   + +   E   V  A+ L   M  +YR   L  G +I GWD ++G  +Y V
Sbjct: 90  ADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYRE-DLMAGIIIAGWDPQEGGQVYSV 148

Query: 187 DEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVV 246
              G  +  +    GSG++Y YG +D+ YR  ++ EE       A+A A  RD  SGGV+
Sbjct: 149 PMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVI 208

Query: 247 NMYHMKEDG 255
            +  + E G
Sbjct: 209 RLAAIAESG 217


>gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo
           sapiens]
          Length = 209

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 62/179 (34%), Positives = 92/179 (51%), Gaps = 1/179 (0%)

Query: 68  EMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYW 127
           E+  GTT +A +F  GV+   DSR SAG  +     +K+  ++  +   +SG AAD Q  
Sbjct: 6   EVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAV 65

Query: 128 ERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVD 187
             + A +  L+ +   E   V AA+ ++ N+  +YR   LS   M+ GWD++  G  Y  
Sbjct: 66  ADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYRE-DLSAHLMVAGWDQREGGQVYGT 124

Query: 188 EHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVV 246
             G          GSG+T+ YG +D+ Y+P +SPEE       AIA A  RD  SGGV+
Sbjct: 125 LGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVI 183


>gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo
           sapiens]
          Length = 219

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 62/179 (34%), Positives = 92/179 (51%), Gaps = 1/179 (0%)

Query: 68  EMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYW 127
           E+  GTT +A +F  GV+   DSR SAG  +     +K+  ++  +   +SG AAD Q  
Sbjct: 16  EVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAV 75

Query: 128 ERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVD 187
             + A +  L+ +   E   V AA+ ++ N+  +YR   LS   M+ GWD++  G  Y  
Sbjct: 76  ADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYRE-DLSAHLMVAGWDQREGGQVYGT 134

Query: 188 EHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVV 246
             G          GSG+T+ YG +D+ Y+P +SPEE       AIA A  RD  SGGV+
Sbjct: 135 LGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVI 193


>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
          Length = 277

 Score = 82.0 bits (201), Expect = 5e-16
 Identities = 50/177 (28%), Positives = 88/177 (49%), Gaps = 1/177 (0%)

Query: 72  GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 131
           GTT     ++ G++   D+RA+ G  ++    +K+  I+P +    +G AAD     +L+
Sbjct: 43  GTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI 102

Query: 132 AKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGT 191
           +    L+ L  G    V  A+++L  M+ +Y+G  +    ++ G D  GP LY +  HG+
Sbjct: 103 SSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGS 161

Query: 192 RLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNM 248
                  + GSG+  A  V +  +RP++  EEA +L   AIA     D  SG  +++
Sbjct: 162 TDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDL 218


>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
          Length = 273

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 55/177 (31%), Positives = 88/177 (49%), Gaps = 3/177 (1%)

Query: 72  GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 131
           GTT     FQ GVI   D+RA+  S ++     K+  I P +    +G AAD +   R++
Sbjct: 39  GTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMV 98

Query: 132 AKECRLYYLRNGERISVSAASKLLSNMMCQYRG-MGLSMGSMICGWDKKGPGLYYVDEHG 190
           A +  L+ L  G    V+  +++L   + +Y+G +G S+  ++ G D  GP LY V  HG
Sbjct: 99  ASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASL--IVGGVDLTGPQLYGVHPHG 156

Query: 191 TRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVN 247
           +       + GSG   A  V++  ++PN++ E A  L   A+      D  SGG V+
Sbjct: 157 SYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVD 213


>gi|22538467 proteasome beta 4 subunit [Homo sapiens]
          Length = 264

 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 61/213 (28%), Positives = 93/213 (43%), Gaps = 10/213 (4%)

Query: 66  QIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQ 125
           Q  M  GT+ L  KF+ GV+ A D   S GS      +++++ +N   +   SG  AD Q
Sbjct: 47  QNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQ 106

Query: 126 YWERLLAK-ECRLYYLRNGERISVSAASKLLSNMMCQYRG-MGLSMGSMICGWDKKGPG- 182
           Y +++L +       L +G   S  A    L+  M   R  M     +M+ G    G   
Sbjct: 107 YLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESF 166

Query: 183 LYYVDEHGTRLSGNMFSTGSGNTYAYGVMDS--GYRPNLSPEEAYDLGRRAIAYATHRDS 240
           L YVD  G        +TG G   A  ++      +P LS  EA DL  R +    +RD+
Sbjct: 167 LGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDA 226

Query: 241 YSGGVVNMYHMKEDGWVKVE---STDVS-DLLH 269
            S     +  + E G V++E   ST+ + D+ H
Sbjct: 227 RSYNRFQIATVTEKG-VEIEGPLSTETNWDIAH 258


>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
          Length = 241

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 38/162 (23%), Positives = 77/162 (47%), Gaps = 10/162 (6%)

Query: 72  GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 131
           G+T +  +   GV  AV+ R ++   +    + K++EI+ ++   MSG  AD +      
Sbjct: 34  GSTAIGIQTSEGVCLAVEKRITS-PLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKA 92

Query: 132 AKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSM---------ICGWDKKGPG 182
             E + ++    E ++V + ++ +SN+  Q+       G+M           G D+KGP 
Sbjct: 93  RVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQ 152

Query: 183 LYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEA 224
           L+++D  GT +  +  + GS +  A   +   Y  +++ +EA
Sbjct: 153 LFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEA 194


>gi|22538465 proteasome beta 3 subunit [Homo sapiens]
          Length = 205

 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 44/187 (23%), Positives = 85/187 (45%), Gaps = 3/187 (1%)

Query: 71  HGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERL 130
           +G   +A K ++ V  A D R    + +      K+  +   L   ++G A D Q   + 
Sbjct: 7   NGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQR 66

Query: 131 LAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG--PGLYYVDE 188
           L     LY L+ G +I       +++N++ + R        +I G D K   P +  +D 
Sbjct: 67  LKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDL 126

Query: 189 HGTRLSGNMFS-TGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVN 247
            G  +  + F  +G+     YG+ +S + PN+ P+  ++   +A+  A  RD+ SG  V 
Sbjct: 127 IGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVI 186

Query: 248 MYHMKED 254
           ++ +++D
Sbjct: 187 VHIIEKD 193


>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
          Length = 234

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 53/219 (24%), Positives = 94/219 (42%), Gaps = 23/219 (10%)

Query: 65  VQIE-----MAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSG 119
           VQIE     +A G  ++  K  +GV+ A + +  +  Y     V+KV  I  ++    SG
Sbjct: 20  VQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILY-DERSVHKVEPITKHIGLVYSG 78

Query: 120 CAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMG----LSMGSMICG 175
              D +       K  + YYL   E I  +   + ++++M +Y   G      +  +ICG
Sbjct: 79  MGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICG 138

Query: 176 WDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYG--VMDSGYRPNLSPEEAYDLGRRAIA 233
           W++  P L+  D  G   +    +T  G  Y  G   ++  Y  +L  E+A        A
Sbjct: 139 WNEGRPYLFQSDPSGAYFAWK--ATAMGKNYVNGKTFLEKRYNEDLELEDAIH-----TA 191

Query: 234 YATHRDSYSGGV----VNMYHMKEDGWVKVESTDVSDLL 268
             T ++S+ G +    + +    E G+ ++  T+V D L
Sbjct: 192 ILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYL 230


>gi|4506195 proteasome beta 2 subunit [Homo sapiens]
          Length = 201

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 33/132 (25%), Positives = 61/132 (46%), Gaps = 3/132 (2%)

Query: 104 NKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMM--CQ 161
           +K+ +++  +L    G A D   +   + K  +LY +RNG  +S +AA+      +  C 
Sbjct: 33  DKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCL 92

Query: 162 YRGMGLSMGSMICGWDK-KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLS 220
                  +  ++ G+D+ +GP LYY+D           + G G      ++D  Y P +S
Sbjct: 93  RSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTIS 152

Query: 221 PEEAYDLGRRAI 232
            E A +L R+ +
Sbjct: 153 RERAVELLRKCL 164


>gi|4506193 proteasome beta 1 subunit [Homo sapiens]
          Length = 241

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 44/195 (22%), Positives = 85/195 (43%), Gaps = 10/195 (5%)

Query: 71  HGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERL 130
           +G T LA   +   I A D+R S G  I      K  ++    +   SG   DC    ++
Sbjct: 36  NGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKI 95

Query: 131 LAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPG-LYYVDEH 189
           +    ++Y   N + ++  A + +LS ++   R     + ++I G D++G G +Y  D  
Sbjct: 96  IEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPV 155

Query: 190 GTRLSGNMFSTGSGNTYAYGVMDS--GYR-------PNLSPEEAYDLGRRAIAYATHRDS 240
           G+    +  + GS +     ++D+  G++         LS + A  L +     A  RD 
Sbjct: 156 GSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDV 215

Query: 241 YSGGVVNMYHMKEDG 255
           Y+G  + +  + ++G
Sbjct: 216 YTGDALRICIVTKEG 230


>gi|221219026 pleckstrin homology-like domain, family B, member 1
            isoform b [Homo sapiens]
          Length = 1319

 Score = 31.2 bits (69), Expect = 1.0
 Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 10/73 (13%)

Query: 154  LLSNMMCQYRGMGLSMGSMICGWDK--------KGPGLYYVDEHGTRLSGNMFSTGSGNT 205
            +LS+ +C  RG  + MG  I  W K        K    YYVD+H T+L G ++       
Sbjct: 1206 VLSSKVC--RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEV 1263

Query: 206  YAYGVMDSGYRPN 218
            Y   +  +   PN
Sbjct: 1264 YYDHLRSAAKSPN 1276


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 11/107 (10%)

Query: 115 GTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMIC 174
           G++  CAA C+  E      CR +   + E+  V  A    S+++ + R + L    +  
Sbjct: 44  GSIEECAAKCEEDEEFT---CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYL 100

Query: 175 GWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSP 221
              K G G  Y         G M  T +G T       S +RP  SP
Sbjct: 101 SECKTGNGKNY--------RGTMSKTKNGITCQKWSSTSPHRPRFSP 139


>gi|221219024 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score = 29.6 bits (65), Expect = 3.0
 Identities = 19/53 (35%), Positives = 27/53 (50%), Gaps = 10/53 (18%)

Query: 154  LLSNMMCQYRGMGLSMGSMICGWDK--------KGPGLYYVDEHGTRLSGNMF 198
            +LS+ +C  RG  + MG  I  W K        K    YYVD+H T+L G ++
Sbjct: 1253 VLSSKVC--RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIY 1303


>gi|38424073 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score = 29.6 bits (65), Expect = 3.0
 Identities = 19/53 (35%), Positives = 27/53 (50%), Gaps = 10/53 (18%)

Query: 154  LLSNMMCQYRGMGLSMGSMICGWDK--------KGPGLYYVDEHGTRLSGNMF 198
            +LS+ +C  RG  + MG  I  W K        K    YYVD+H T+L G ++
Sbjct: 1253 VLSSKVC--RGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIY 1303


>gi|4502247 armadillo repeat protein [Homo sapiens]
          Length = 962

 Score = 28.9 bits (63), Expect = 5.1
 Identities = 25/78 (32%), Positives = 30/78 (38%), Gaps = 14/78 (17%)

Query: 12  GQRPESALPVA---GSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQ-----------SL 57
           G RP  A P+    G G  + PGH       PE   P G    E FQ           SL
Sbjct: 209 GMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDTRSL 268

Query: 58  GGDGERNVQIEMAHGTTT 75
             D E   ++E  +GT T
Sbjct: 269 AADDEGGPELEPDYGTAT 286


>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
          Length = 491

 Score = 28.5 bits (62), Expect = 6.7
 Identities = 38/155 (24%), Positives = 59/155 (38%), Gaps = 14/155 (9%)

Query: 15  PESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIE-----M 69
           P  A     +   SD    + S  SP L  P  +     FQ+  G    +  I      M
Sbjct: 31  PTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPG---FQNGRGSSTSSSSITGETVAM 87

Query: 70  AHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYL-LGTMSGCAADCQYWE 128
            H       +  H +I          + I  L  + +++I  +L    +  CA  C+ W 
Sbjct: 88  VHSPPPT--RLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWY 145

Query: 129 RLLAKECRLYYL--RNGERISVSAASKLLSNMMCQ 161
            L A + RL+      GE I+V  A K+L+  +CQ
Sbjct: 146 NL-AWDPRLWRTIRLTGETINVDRALKVLTRRLCQ 179


>gi|155969697 keratin 6C [Homo sapiens]
          Length = 564

 Score = 28.1 bits (61), Expect = 8.7
 Identities = 28/99 (28%), Positives = 38/99 (38%), Gaps = 12/99 (12%)

Query: 126 YWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQY-------RGMGLSMGSMICGWDK 178
           Y + L  +ECRL    NGE +     S + S +   Y        G+GL  GS       
Sbjct: 465 YRKLLEGEECRL----NGEGVGQVNVSVVQSTISSGYGGASGVGSGLGLGGGSSYSYGSG 520

Query: 179 KGPGLYYVDEHGTRLSGNMFSTGSG-NTYAYGVMDSGYR 216
            G G  +    G  + G + S G G +T  Y    S  R
Sbjct: 521 LGIGGGFSSSSGRAIGGGLSSVGGGSSTIKYTTTSSSSR 559


>gi|5031839 keratin 6A [Homo sapiens]
          Length = 564

 Score = 28.1 bits (61), Expect = 8.7
 Identities = 28/99 (28%), Positives = 38/99 (38%), Gaps = 12/99 (12%)

Query: 126 YWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQY-------RGMGLSMGSMICGWDK 178
           Y + L  +ECRL    NGE +     S + S +   Y        G+GL  GS       
Sbjct: 465 YRKLLEGEECRL----NGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSG 520

Query: 179 KGPGLYYVDEHGTRLSGNMFSTGSG-NTYAYGVMDSGYR 216
            G G  +    G  + G + S G G +T  Y    S  R
Sbjct: 521 LGVGGGFSSSSGRAIGGGLSSVGGGSSTIKYTTTSSSSR 559


>gi|197313732 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 28.1 bits (61), Expect = 8.7
 Identities = 18/64 (28%), Positives = 26/64 (40%), Gaps = 8/64 (12%)

Query: 163  RGMGLSMGSMICGWDK--------KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSG 214
            RG  + MG  I  W K        K    YY D+H T+L G ++       Y   + ++ 
Sbjct: 1147 RGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNAN 1206

Query: 215  YRPN 218
              PN
Sbjct: 1207 KSPN 1210


>gi|197313730 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 28.1 bits (61), Expect = 8.7
 Identities = 18/64 (28%), Positives = 26/64 (40%), Gaps = 8/64 (12%)

Query: 163  RGMGLSMGSMICGWDK--------KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSG 214
            RG  + MG  I  W K        K    YY D+H T+L G ++       Y   + ++ 
Sbjct: 1147 RGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNAN 1206

Query: 215  YRPN 218
              PN
Sbjct: 1207 KSPN 1210


>gi|197313728 pleckstrin homology-like domain, family B, member 2
            isoform b [Homo sapiens]
          Length = 1237

 Score = 28.1 bits (61), Expect = 8.7
 Identities = 18/64 (28%), Positives = 26/64 (40%), Gaps = 8/64 (12%)

Query: 163  RGMGLSMGSMICGWDK--------KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSG 214
            RG  + MG  I  W K        K    YY D+H T+L G ++       Y   + ++ 
Sbjct: 1131 RGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNAN 1190

Query: 215  YRPN 218
              PN
Sbjct: 1191 KSPN 1194


>gi|21955172 pleckstrin homology-like domain, family B, member 2
            isoform c [Homo sapiens]
          Length = 1210

 Score = 28.1 bits (61), Expect = 8.7
 Identities = 18/64 (28%), Positives = 26/64 (40%), Gaps = 8/64 (12%)

Query: 163  RGMGLSMGSMICGWDK--------KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSG 214
            RG  + MG  I  W K        K    YY D+H T+L G ++       Y   + ++ 
Sbjct: 1104 RGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNAN 1163

Query: 215  YRPN 218
              PN
Sbjct: 1164 KSPN 1167


>gi|9256606 protocadherin beta 12 precursor [Homo sapiens]
          Length = 795

 Score = 28.1 bits (61), Expect = 8.7
 Identities = 18/62 (29%), Positives = 26/62 (41%), Gaps = 4/62 (6%)

Query: 7   CGAPRGQRPESALPVAGSGRRSDPGHYSFSM----RSPELALPRGMQPTEFFQSLGGDGE 62
           C  P G  P   + V+G+G  S   HY   +    RS +    + + P    QS G + E
Sbjct: 725 CSVPEGPFPGHLVDVSGTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTGSEVE 784

Query: 63  RN 64
            N
Sbjct: 785 EN 786


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,944,684
Number of Sequences: 37866
Number of extensions: 501566
Number of successful extensions: 1182
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1158
Number of HSP's gapped (non-prelim): 31
length of query: 276
length of database: 18,247,518
effective HSP length: 101
effective length of query: 175
effective length of database: 14,423,052
effective search space: 2524034100
effective search space used: 2524034100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.