Search of human proteins with 71483646

Search of human proteins with 71483646

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71483646 WD repeat domain 45 isoform 2 [Homo sapiens]
         (360 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71483646 WD repeat domain 45 isoform 2 [Homo sapiens]              733   0.0  
gi|47059042 WD repeat domain 45 isoform 1 [Homo sapiens]              728   0.0  
gi|122939167 WDR45-like [Homo sapiens]                                323   1e-88
gi|157388939 WD repeat domain, phosphoinositide interacting 1 [H...   114   1e-25
gi|75677331 WD repeat domain, phosphoinositide interacting 2 iso...   101   1e-21
gi|54111428 WD repeat domain, phosphoinositide interacting 2 iso...   101   1e-21
gi|75677340 WD repeat domain, phosphoinositide interacting 2 iso...    96   4e-20
gi|75677329 WD repeat domain, phosphoinositide interacting 2 iso...    96   4e-20
gi|7661580 WD repeat domain, phosphoinositide interacting 2 isof...    96   4e-20
gi|18874090 WD repeat domain 48 [Homo sapiens]                         39   0.009
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        39   0.009
gi|153218631 breast carcinoma amplified sequence 3 isoform 1 [Ho...    38   0.012
gi|153218595 breast carcinoma amplified sequence 3 isoform 2 [Ho...    38   0.012
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ...    36   0.061
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ...    36   0.061
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ...    36   0.061
gi|56243583 WD repeat domain 18 [Homo sapiens]                         35   0.080
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    35   0.10 
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]     35   0.14 
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    34   0.18 
gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens]               34   0.18 
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)...    34   0.18 
gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens]    33   0.30 
gi|32699064 WD repeat domain 53 [Homo sapiens]                         33   0.52 
gi|19913369 transducin beta-like 3 [Homo sapiens]                      33   0.52 
gi|16554629 WD repeat domain 5 [Homo sapiens]                          32   0.68 
gi|16554627 WD repeat domain 5 [Homo sapiens]                          32   0.68 
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]               32   0.68 
gi|23199987 WD repeat domain 5B [Homo sapiens]                         32   0.68 
gi|55743075 angio-associated, migratory cell protein [Homo sapiens]    32   0.88 

>gi|71483646 WD repeat domain 45 isoform 2 [Homo sapiens]
          Length = 360

 Score =  733 bits (1892), Expect = 0.0
 Identities = 360/360 (100%), Positives = 360/360 (100%)

Query: 1   MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS 60
           MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS
Sbjct: 1   MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS 60

Query: 61  NLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLK 120
           NLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLK
Sbjct: 61  NLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLK 120

Query: 121 NRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPG 180
           NRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPG
Sbjct: 121 NRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPG 180

Query: 181 TSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATL 240
           TSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATL
Sbjct: 181 TSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATL 240

Query: 241 YCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASF 300
           YCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASF
Sbjct: 241 YCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASF 300

Query: 301 TVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF 360
           TVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
Sbjct: 301 TVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF 360


>gi|47059042 WD repeat domain 45 isoform 1 [Homo sapiens]
          Length = 361

 Score =  728 bits (1880), Expect = 0.0
 Identities = 360/361 (99%), Positives = 360/361 (99%), Gaps = 1/361 (0%)

Query: 1   MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS 60
           MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS
Sbjct: 1   MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRS 60

Query: 61  NLLALVGGGSSPKFSEIS-VLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVL 119
           NLLALVGGGSSPKFSEIS VLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVL
Sbjct: 61  NLLALVGGGSSPKFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVL 120

Query: 120 KNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP 179
           KNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP
Sbjct: 121 KNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP 180

Query: 180 GTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPAT 239
           GTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPAT
Sbjct: 181 GTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPAT 240

Query: 240 LYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLAS 299
           LYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLAS
Sbjct: 241 LYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLAS 300

Query: 300 FTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDD 359
           FTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDD
Sbjct: 301 FTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDD 360

Query: 360 F 360
           F
Sbjct: 361 F 361


>gi|122939167 WDR45-like [Homo sapiens]
          Length = 344

 Score =  323 bits (829), Expect = 1e-88
 Identities = 166/350 (47%), Positives = 226/350 (64%), Gaps = 19/350 (5%)

Query: 8   GVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVG 67
           G+    FNQD  CF C ME G R+YN +PL EK   +  + G +G VEML R N LALVG
Sbjct: 12  GLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLE-GGVGHVEMLFRCNYLALVG 70

Query: 68  GGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYS 127
           GG  PK+    V+IWDD       K+K V+E  F+  V +V++R D+IV+VL + I V++
Sbjct: 71  GGKKPKYPPNKVMIWDDL------KKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFT 124

Query: 128 FPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFT 187
           F  NP +L  F+T  NPKGLC LCP+    LL FPG   G +QLVDLAST+      P  
Sbjct: 125 FTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTE----KPPVD 180

Query: 188 INAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSH 247
           I AH+  ++C++LN  GT +A+AS+KGTLIR+FDT S   + ELRRG+  A +YCINF+ 
Sbjct: 181 IPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQ 240

Query: 248 DSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESA 307
           D+S +C SSD GTVHIFA +D + N++S+LA        + +Y  S+WS + F VP+ S 
Sbjct: 241 DASLICVSSDHGTVHIFAAEDPKRNKQSSLASAS----FLPKYFSSKWSFSKFQVPSGSP 296

Query: 308 CICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDD 357
           CICAFG       N+VIAIC DG+++K++F P G C R+ +  +L++ DD
Sbjct: 297 CICAFGTEP----NAVIAICADGSYYKFLFNPKGECIRDVYAQFLEMTDD 342


>gi|157388939 WD repeat domain, phosphoinositide interacting 1 [Homo
           sapiens]
          Length = 446

 Score =  114 bits (285), Expect = 1e-25
 Identities = 80/264 (30%), Positives = 136/264 (51%), Gaps = 21/264 (7%)

Query: 14  FNQDQSCFCCAMETGVRIYNVEPL--MEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSS 71
           FNQD +      + G +++++  +  +++ H  +E +  + +VE L  S+L+ +V   S 
Sbjct: 22  FNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNE-IPDVYIVERLFSSSLVVVV---SH 77

Query: 72  PKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDN 131
            K  +++V  +    E        +  ++++  +LS+R+   ++++ L+  IY+++  D 
Sbjct: 78  TKPRQMNVYHFKKGTE--------ICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDM 129

Query: 132 PRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGH-KCGSLQLVDLASTKPGTSSAPFTINA 190
                  D   NP GLC L  +     L +PG    G + L D  S K        TI A
Sbjct: 130 KLLKTLLDIPANPTGLCALSINHSNSYLAYPGSLTSGEIVLYDGNSLK-----TVCTIAA 184

Query: 191 HQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDP-ATLYCINFSHDS 249
           H+  +A ++ N  G+ +ASAS+KGT+IR+F     +KL E RRG     T+  + FS DS
Sbjct: 185 HEGTLAAITFNASGSKLASASEKGTVIRVFSVPDGQKLYEFRRGMKRYVTISSLVFSMDS 244

Query: 250 SFLCASSDKGTVHIFALKDTRLNR 273
            FLCASS+  TVHIF L+    +R
Sbjct: 245 QFLCASSNTETVHIFKLEQVTNSR 268


>gi|75677331 WD repeat domain, phosphoinositide interacting 2
           isoform d [Homo sapiens]
          Length = 425

 Score =  101 bits (251), Expect = 1e-21
 Identities = 70/260 (26%), Positives = 127/260 (48%), Gaps = 19/260 (7%)

Query: 14  FNQDQSCFCCAMETGVRIYNVEPLMEKGHL-DHEQVGSMGLVEMLHRSNLLALVGGGSSP 72
           FNQD +      ++G + +++  + +   + +      + +VE L  S+L+A+V   +  
Sbjct: 20  FNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPR 79

Query: 73  KFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNP 132
           K                  K   +  ++++  +L+V++   ++++ L+  +Y+++  D  
Sbjct: 80  KLKVCHF-----------KKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMK 128

Query: 133 RKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINAH 191
                 +T  NP GLC L  + +   L +PG    G +Q+ D  + +     A   I AH
Sbjct: 129 VLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR-----AANMIPAH 183

Query: 192 QSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDSS 250
            S +A ++ +  GT +A+AS+KGT+IR+F     +KL E RRG       C + FS D  
Sbjct: 184 DSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGM 243

Query: 251 FLCASSDKGTVHIFALKDTR 270
           FL ASS+  TVHIF L+  +
Sbjct: 244 FLSASSNTETVHIFKLETVK 263


>gi|54111428 WD repeat domain, phosphoinositide interacting 2
           isoform b [Homo sapiens]
          Length = 436

 Score =  101 bits (251), Expect = 1e-21
 Identities = 70/260 (26%), Positives = 127/260 (48%), Gaps = 19/260 (7%)

Query: 14  FNQDQSCFCCAMETGVRIYNVEPLMEKGHL-DHEQVGSMGLVEMLHRSNLLALVGGGSSP 72
           FNQD +      ++G + +++  + +   + +      + +VE L  S+L+A+V   +  
Sbjct: 20  FNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPR 79

Query: 73  KFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNP 132
           K                  K   +  ++++  +L+V++   ++++ L+  +Y+++  D  
Sbjct: 80  KLKVCHF-----------KKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMK 128

Query: 133 RKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINAH 191
                 +T  NP GLC L  + +   L +PG    G +Q+ D  + +     A   I AH
Sbjct: 129 VLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR-----AANMIPAH 183

Query: 192 QSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDSS 250
            S +A ++ +  GT +A+AS+KGT+IR+F     +KL E RRG       C + FS D  
Sbjct: 184 DSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGM 243

Query: 251 FLCASSDKGTVHIFALKDTR 270
           FL ASS+  TVHIF L+  +
Sbjct: 244 FLSASSNTETVHIFKLETVK 263


>gi|75677340 WD repeat domain, phosphoinositide interacting 2
           isoform e [Homo sapiens]
          Length = 384

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 65/220 (29%), Positives = 110/220 (50%), Gaps = 18/220 (8%)

Query: 53  LVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRH 112
           +VE L  S+L+A+V   +  K                  K   +  ++++  +L+V++  
Sbjct: 19  IVERLFSSSLVAIVSLKAPRKLKVCHF-----------KKGTEICNYSYSNTILAVKLNR 67

Query: 113 DKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQL 171
            ++++ L+  +Y+++  D        +T  NP GLC L  + +   L +PG    G +Q+
Sbjct: 68  QRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQV 127

Query: 172 VDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVEL 231
            D  + +     A   I AH S +A ++ +  GT +A+AS+KGT+IR+F     +KL E 
Sbjct: 128 FDTINLR-----AANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 182

Query: 232 RRGTDPATLYC-INFSHDSSFLCASSDKGTVHIFALKDTR 270
           RRG       C + FS D  FL ASS+  TVHIF L+  +
Sbjct: 183 RRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 222


>gi|75677329 WD repeat domain, phosphoinositide interacting 2
           isoform c [Homo sapiens]
          Length = 443

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 65/220 (29%), Positives = 110/220 (50%), Gaps = 18/220 (8%)

Query: 53  LVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRH 112
           +VE L  S+L+A+V   +  K                  K   +  ++++  +L+V++  
Sbjct: 78  IVERLFSSSLVAIVSLKAPRKLKVCHF-----------KKGTEICNYSYSNTILAVKLNR 126

Query: 113 DKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQL 171
            ++++ L+  +Y+++  D        +T  NP GLC L  + +   L +PG    G +Q+
Sbjct: 127 QRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQV 186

Query: 172 VDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVEL 231
            D  + +     A   I AH S +A ++ +  GT +A+AS+KGT+IR+F     +KL E 
Sbjct: 187 FDTINLR-----AANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 241

Query: 232 RRGTDPATLYC-INFSHDSSFLCASSDKGTVHIFALKDTR 270
           RRG       C + FS D  FL ASS+  TVHIF L+  +
Sbjct: 242 RRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 281


>gi|7661580 WD repeat domain, phosphoinositide interacting 2 isoform
           a [Homo sapiens]
          Length = 454

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 65/220 (29%), Positives = 110/220 (50%), Gaps = 18/220 (8%)

Query: 53  LVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRH 112
           +VE L  S+L+A+V   +  K                  K   +  ++++  +L+V++  
Sbjct: 78  IVERLFSSSLVAIVSLKAPRKLKVCHF-----------KKGTEICNYSYSNTILAVKLNR 126

Query: 113 DKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQL 171
            ++++ L+  +Y+++  D        +T  NP GLC L  + +   L +PG    G +Q+
Sbjct: 127 QRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQV 186

Query: 172 VDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVEL 231
            D  + +     A   I AH S +A ++ +  GT +A+AS+KGT+IR+F     +KL E 
Sbjct: 187 FDTINLR-----AANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 241

Query: 232 RRGTDPATLYC-INFSHDSSFLCASSDKGTVHIFALKDTR 270
           RRG       C + FS D  FL ASS+  TVHIF L+  +
Sbjct: 242 RRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 281


>gi|18874090 WD repeat domain 48 [Homo sapiens]
          Length = 677

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 23/96 (23%), Positives = 51/96 (53%), Gaps = 3/96 (3%)

Query: 175 ASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRG 234
           A T    +    +++ ++  I  +++NQ GT++ S S +  ++R++D ++  KL++L+  
Sbjct: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTE-KVLRVWDPRTCAKLMKLKGH 209

Query: 235 TDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTR 270
           TD      +N   D +   + S  GT+ +++L   R
Sbjct: 210 TDNVKALLLN--RDGTQCLSGSSDGTIRLWSLGQQR 243


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 18/87 (20%), Positives = 47/87 (54%), Gaps = 1/87 (1%)

Query: 188 INAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSH 247
           ++ HQ  +  +S    G+++  ++ +   +R++D     K +++  G     +YC + S 
Sbjct: 149 LSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSG-HLQWVYCCSISP 207

Query: 248 DSSFLCASSDKGTVHIFALKDTRLNRR 274
           D S LC+++ + +V +++++   L R+
Sbjct: 208 DCSMLCSAAGEKSVFLWSMRSYTLIRK 234


>gi|153218631 breast carcinoma amplified sequence 3 isoform 1 [Homo
           sapiens]
          Length = 928

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 9/86 (10%)

Query: 190 AHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSK---------EKLVELRRGTDPATL 240
           AH+  + C++ N  G ++ +    G    +F   +            L  L RG   A +
Sbjct: 349 AHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHPWSSSQCAVHHLYTLHRGETEAKV 408

Query: 241 YCINFSHDSSFLCASSDKGTVHIFAL 266
             I FSHD  ++  S+ +GT H+F +
Sbjct: 409 QDICFSHDCRWVVVSTLRGTSHVFPI 434


>gi|153218595 breast carcinoma amplified sequence 3 isoform 2 [Homo
           sapiens]
          Length = 913

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 9/86 (10%)

Query: 190 AHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSK---------EKLVELRRGTDPATL 240
           AH+  + C++ N  G ++ +    G    +F   +            L  L RG   A +
Sbjct: 349 AHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHPWSSSQCAVHHLYTLHRGETEAKV 408

Query: 241 YCINFSHDSSFLCASSDKGTVHIFAL 266
             I FSHD  ++  S+ +GT H+F +
Sbjct: 409 QDICFSHDCRWVVVSTLRGTSHVFPI 434


>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
           sapiens]
          Length = 769

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 44/158 (27%), Positives = 64/158 (40%), Gaps = 25/158 (15%)

Query: 122 RIYVYSFPDNPRKLFEFD--TRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP 179
           +I+  S P +   + + D   RDN    C L P   + L+V  G +  +L + DLAS  P
Sbjct: 507 KIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD-GRTLIV--GGEASTLTIWDLASPTP 563

Query: 180 G-----TSSAP--FTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELR 232
                 TSSAP  + +        C S    G +        TL+R F            
Sbjct: 564 RIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGH--------- 614

Query: 233 RGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTR 270
             TD A+  CI+ SHD + L       TV  + L++ R
Sbjct: 615 --TDGAS--CIDISHDGTKLWTGGLDNTVRSWDLREGR 648


>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
           sapiens]
          Length = 760

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 44/158 (27%), Positives = 64/158 (40%), Gaps = 25/158 (15%)

Query: 122 RIYVYSFPDNPRKLFEFD--TRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP 179
           +I+  S P +   + + D   RDN    C L P   + L+V  G +  +L + DLAS  P
Sbjct: 498 KIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD-GRTLIV--GGEASTLTIWDLASPTP 554

Query: 180 G-----TSSAP--FTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELR 232
                 TSSAP  + +        C S    G +        TL+R F            
Sbjct: 555 RIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGH--------- 605

Query: 233 RGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTR 270
             TD A+  CI+ SHD + L       TV  + L++ R
Sbjct: 606 --TDGAS--CIDISHDGTKLWTGGLDNTVRSWDLREGR 639


>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
           sapiens]
          Length = 772

 Score = 35.8 bits (81), Expect = 0.061
 Identities = 44/158 (27%), Positives = 64/158 (40%), Gaps = 25/158 (15%)

Query: 122 RIYVYSFPDNPRKLFEFD--TRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKP 179
           +I+  S P +   + + D   RDN    C L P   + L+V  G +  +L + DLAS  P
Sbjct: 510 KIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD-GRTLIV--GGEASTLTIWDLASPTP 566

Query: 180 G-----TSSAP--FTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELR 232
                 TSSAP  + +        C S    G +        TL+R F            
Sbjct: 567 RIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGH--------- 617

Query: 233 RGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTR 270
             TD A+  CI+ SHD + L       TV  + L++ R
Sbjct: 618 --TDGAS--CIDISHDGTKLWTGGLDNTVRSWDLREGR 651


>gi|56243583 WD repeat domain 18 [Homo sapiens]
          Length = 432

 Score = 35.4 bits (80), Expect = 0.080
 Identities = 25/75 (33%), Positives = 38/75 (50%), Gaps = 10/75 (13%)

Query: 160 VFPGHKCGSLQLVDLASTKPGTSSAPF--------TINAHQSDIACVSLNQPGTVVASAS 211
           +F G   GS+  VDL  T PG     F            H++ + C+S++  G+V+ S S
Sbjct: 230 MFCGGSEGSIFQVDLF-TWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGS 288

Query: 212 QKGTLIRLFDTQSKE 226
              T +RL+D QSK+
Sbjct: 289 HDET-VRLWDVQSKQ 302


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 36/141 (25%), Positives = 68/141 (48%), Gaps = 12/141 (8%)

Query: 133 RKLFEFDTRDNPKGLCD----LCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTI 188
           RK  ++  +DN   + D    +C S + ++L   G + G +++  + S   G     F  
Sbjct: 249 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLA-TGAQDGKIKVWKIQS---GQCLRRFE- 303

Query: 189 NAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHD 248
            AH   + C+S ++  + + SAS   T IR+   +S + L E R  +  + +    F+ D
Sbjct: 304 RAHSKGVTCLSFSKDSSQILSASFDQT-IRIHGLKSGKTLKEFRGHS--SFVNEATFTQD 360

Query: 249 SSFLCASSDKGTVHIFALKDT 269
             ++ ++S  GTV I+ +K T
Sbjct: 361 GHYIISASSDGTVKIWNMKTT 381


>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
          Length = 606

 Score = 34.7 bits (78), Expect = 0.14
 Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 2/80 (2%)

Query: 186 FTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRG-TDPATLYCIN 244
           FTI  H   + CV  +  G   A+AS  G  I ++D ++ EK+  L         +Y I+
Sbjct: 183 FTIGDHSRFVNCVRFSPDGNRFATASADGQ-IYIYDGKTGEKVCALGGSKAHDGGIYAIS 241

Query: 245 FSHDSSFLCASSDKGTVHIF 264
           +S DS+ L ++S   T  I+
Sbjct: 242 WSPDSTHLLSASGDKTSKIW 261


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 34.3 bits (77), Expect = 0.18
 Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 3/74 (4%)

Query: 187 TINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFS 246
           T   H+  +  V  NQ GT++AS S   T +R++   +KE   ELR       + CI+++
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQT-VRVWVVATKECKAELRE--HEHVVECISWA 285

Query: 247 HDSSFLCASSDKGT 260
            +SS+   S   G+
Sbjct: 286 PESSYSSISEATGS 299


>gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens]
          Length = 2527

 Score = 34.3 bits (77), Expect = 0.18
 Identities = 36/119 (30%), Positives = 57/119 (47%), Gaps = 15/119 (12%)

Query: 167  GSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLN----QPGTVVASASQKGTLIRLFDT 222
            G L  +DL +T+  TS          S I C++L     +  + + S +Q GTL+ + +T
Sbjct: 2177 GQLSFLDL-NTEGYTSE-----EVADSRILCLALVHLPVEKESWIVSGTQSGTLL-VINT 2229

Query: 223  QSKEKLVELRRGTDPAT-LYCINFSHDS---SFLCASSDKGTVHIFALKDTRLNRRSAL 277
            +  +K   L + TD  T LYC +FS  S   +FL   +  G + IF  K  +L   + L
Sbjct: 2230 EDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPL 2288


>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
           [Homo sapiens]
          Length = 906

 Score = 34.3 bits (77), Expect = 0.18
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 7/95 (7%)

Query: 180 GTSSAPFTINAHQSDIACVSLNQPGT---VVASASQKGTLIRLFDTQSKEKLVELRRGTD 236
           G+SS  FT+  H+  + C+     G    +++ A  +  L++++D Q+K  +  L     
Sbjct: 173 GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDR--LVKIWDYQNKTCVQTLEGHAQ 230

Query: 237 PATLYCINFSHDSSFLCASSDKGTVHIFALKDTRL 271
              + C +F  +   +   S+ GTV I+     RL
Sbjct: 231 --NVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263


>gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens]
          Length = 1429

 Score = 33.5 bits (75), Expect = 0.30
 Identities = 29/127 (22%), Positives = 60/127 (47%), Gaps = 9/127 (7%)

Query: 167  GSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKE 226
            G L L + A++K       F +  H+S +ACV ++    +V S S+   L+ L+D Q+++
Sbjct: 1234 GDLFLYECATSKA------FPLETHRSRVACVEVSHKEQLVVSGSE-DALLCLWDLQARK 1286

Query: 227  KLVELRRGTDPAT-LYCINFSHDSSFLCASSDKGTVHIFALKD-TRLNRRSALARVGKVG 284
               E+   +     + C  FS D  ++       ++ ++++ D T L  +   A V ++ 
Sbjct: 1287 WKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNRII 1346

Query: 285  PMIGQYV 291
            P    ++
Sbjct: 1347 PTTSGFI 1353


>gi|32699064 WD repeat domain 53 [Homo sapiens]
          Length = 358

 Score = 32.7 bits (73), Expect = 0.52
 Identities = 18/66 (27%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 168 SLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEK 227
           ++ ++D+ S K          + ++ +I C+SLNQ   ++ASA   G  I++ D ++K+ 
Sbjct: 74  TISVLDVRSLKDSLDH----FHVNEEEINCLSLNQTENLLASADDSGA-IKILDLENKKV 128

Query: 228 LVELRR 233
           +  L+R
Sbjct: 129 IRSLKR 134


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 32.7 bits (73), Expect = 0.52
 Identities = 35/130 (26%), Positives = 54/130 (41%), Gaps = 18/130 (13%)

Query: 151 CPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAP----------FTINAHQSDIACVSL 200
           C  L++  LV     C +++L  L       ++AP           T   H  DI  V++
Sbjct: 429 CSRLKESFLVTGSQDC-TVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAI 487

Query: 201 NQPGTVVASASQKGT--LIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDK 258
                ++A+ SQ  T  L  L   Q        RRG     L+C+ FS     L  +S  
Sbjct: 488 APNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRG-----LWCVQFSPMDQVLATASAD 542

Query: 259 GTVHIFALKD 268
           GT+ ++AL+D
Sbjct: 543 GTIKLWALQD 552


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 32.3 bits (72), Expect = 0.68
 Identities = 22/81 (27%), Positives = 45/81 (55%), Gaps = 3/81 (3%)

Query: 187 TINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFS 246
           TI+ H+  I+ V+ +    ++ SAS   TL +++D  S + L  L+  ++   ++C NF+
Sbjct: 82  TISGHKLGISDVAWSSDSNLLVSASDDKTL-KIWDVSSGKCLKTLKGHSN--YVFCCNFN 138

Query: 247 HDSSFLCASSDKGTVHIFALK 267
             S+ + + S   +V I+ +K
Sbjct: 139 PQSNLIVSGSFDESVRIWDVK 159


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 32.3 bits (72), Expect = 0.68
 Identities = 22/81 (27%), Positives = 45/81 (55%), Gaps = 3/81 (3%)

Query: 187 TINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFS 246
           TI+ H+  I+ V+ +    ++ SAS   TL +++D  S + L  L+  ++   ++C NF+
Sbjct: 82  TISGHKLGISDVAWSSDSNLLVSASDDKTL-KIWDVSSGKCLKTLKGHSN--YVFCCNFN 138

Query: 247 HDSSFLCASSDKGTVHIFALK 267
             S+ + + S   +V I+ +K
Sbjct: 139 PQSNLIVSGSFDESVRIWDVK 159


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score = 32.3 bits (72), Expect = 0.68
 Identities = 35/129 (27%), Positives = 57/129 (44%), Gaps = 21/129 (16%)

Query: 147 LCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSL--NQPG 204
           LC      ++Q+++  G K G LQL DLAS      +   TI+AH   +  +SL  +Q G
Sbjct: 458 LCSFFVPGDRQVVI--GTKTGKLQLYDLAS-----GNLLETIDAHDGALWSMSLSPDQRG 510

Query: 205 TVVASASQKGTLIRLFD---------TQSKEKLVELRRGTDPATLYCINFSHDSSFLCAS 255
            V   A +    ++ +D         TQ +  + + R       + C+++S +   L  S
Sbjct: 511 FVTGGADKS---VKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVS 567

Query: 256 SDKGTVHIF 264
               TV IF
Sbjct: 568 LLDCTVKIF 576


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 32.3 bits (72), Expect = 0.68
 Identities = 23/81 (28%), Positives = 45/81 (55%), Gaps = 3/81 (3%)

Query: 187 TINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFS 246
           T+  H  +I+ V+ +   + + SAS   TL +L+D +S + L  L+  ++   ++C NF+
Sbjct: 78  TLYGHNLEISDVAWSSDSSRLVSASDDKTL-KLWDVRSGKCLKTLKGHSN--YVFCCNFN 134

Query: 247 HDSSFLCASSDKGTVHIFALK 267
             S+ + + S   TV I+ +K
Sbjct: 135 PPSNLIISGSFDETVKIWEVK 155


>gi|55743075 angio-associated, migratory cell protein [Homo sapiens]
          Length = 434

 Score = 32.0 bits (71), Expect = 0.88
 Identities = 22/91 (24%), Positives = 37/91 (40%), Gaps = 3/91 (3%)

Query: 180 GTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPAT 239
           G   +  T   H + + CVSL+     +A    +     ++     E L E     D  T
Sbjct: 79  GPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVT 138

Query: 240 LYCINFSHDSSFLCASSDKGTVHIFALKDTR 270
             C  FSHDS+ +      G + ++ + DT+
Sbjct: 139 --CAGFSHDSTLVATGDMSGLLKVWQV-DTK 166


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,821,706
Number of Sequences: 37866
Number of extensions: 590438
Number of successful extensions: 1177
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 1122
Number of HSP's gapped (non-prelim): 71
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.