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Search of human proteins with 71164884
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens] 1044 0.0
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens] 1044 0.0
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens] 1044 0.0
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens] 995 0.0
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens] 814 0.0
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens] 798 0.0
gi|4507903 vaccinia related kinase 1 [Homo sapiens] 347 2e-95
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens] 192 5e-49
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens] 192 5e-49
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 123 5e-28
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 123 5e-28
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 122 8e-28
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 122 8e-28
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 113 5e-25
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens] 108 1e-23
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens] 108 1e-23
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 106 6e-23
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens] 104 2e-22
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens] 103 4e-22
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens] 103 4e-22
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 100 2e-21
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens] 100 4e-21
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens] 97 3e-20
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 96 8e-20
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 68 2e-11
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 59 1e-08
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 59 1e-08
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 56 9e-08
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 56 9e-08
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 53 6e-07
>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 1044 bits (2700), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
Query: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
Query: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
Sbjct: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
Query: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
EETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 1044 bits (2700), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
Query: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
Query: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
Sbjct: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
Query: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
EETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 1044 bits (2700), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
Query: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI 420
Query: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
Sbjct: 421 SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS 480
Query: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
EETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 481 EETNADVYYYRIIIPVLLMLVFLALFFL 508
>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
Length = 485
Score = 995 bits (2572), Expect = 0.0
Identities = 485/485 (100%), Positives = 485/485 (100%)
Query: 24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 83
MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK
Sbjct: 1 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 60
Query: 84 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTV 143
DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTV
Sbjct: 61 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTV 120
Query: 144 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ 203
LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ
Sbjct: 121 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ 180
Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA
Sbjct: 181 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 240
Query: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPL 323
KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPL
Sbjct: 241 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPL 300
Query: 324 DFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEK 383
DFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEK
Sbjct: 301 DFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEK 360
Query: 384 LIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFK 443
LIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFK
Sbjct: 361 LIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFK 420
Query: 444 KSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFL 503
KSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFL
Sbjct: 421 KSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFL 480
Query: 504 ALFFL 508
ALFFL
Sbjct: 481 ALFFL 485
>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
Length = 396
Score = 814 bits (2103), Expect = 0.0
Identities = 394/394 (100%), Positives = 394/394 (100%)
Query: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
Sbjct: 1 MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV 60
Query: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
Sbjct: 61 KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV 120
Query: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
Sbjct: 121 MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD 180
Query: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
Sbjct: 181 QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM 240
Query: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
Sbjct: 241 LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY 300
Query: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
Sbjct: 301 DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI 360
Query: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ 394
EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ
Sbjct: 361 EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ 394
>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
Length = 390
Score = 798 bits (2060), Expect = 0.0
Identities = 390/390 (100%), Positives = 390/390 (100%)
Query: 119 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 178
MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 1 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60
Query: 179 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 238
PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 61 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120
Query: 239 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 298
CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180
Query: 299 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 358
AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240
Query: 359 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 418
LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ
Sbjct: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300
Query: 419 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 478
KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT
Sbjct: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360
Query: 479 LSEETNADVYYYRIIIPVLLMLVFLALFFL 508
LSEETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390
>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
Length = 396
Score = 347 bits (889), Expect = 2e-95
Identities = 190/401 (47%), Positives = 248/401 (61%), Gaps = 23/401 (5%)
Query: 8 KYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPE--KDARHVVKVEYQ 65
K L F G+++ DM +W +G IG GGFG IYLA + DA VVKVE
Sbjct: 16 KRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS 75
Query: 66 ENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLG 125
+NGPLF+ELKFYQR AK + I+KWI ++L YLG+P ++GSGL + G+SYRFM+M+R G
Sbjct: 76 DNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG 135
Query: 126 IDLQKISGQNGT-FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYL 184
DLQKI N F + TVLQL +R+LD+LEYIHE+EYVHGDIKA+NLLL YKNPDQVYL
Sbjct: 136 SDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYL 195
Query: 185 ADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWL 244
DYGL+YRYCP G HK+Y+E+P++ H+GTIEFTS+DAH GVA SRR D+EILGYCM++WL
Sbjct: 196 VDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL 255
Query: 245 CGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKP 304
G LPWE NLKDP V+ +K + + + K P + EIA+++ L Y EKP
Sbjct: 256 TGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKP 315
Query: 305 NYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKV 364
Y+ L+ IL +G D S+ V++ K + K + IE+
Sbjct: 316 LYENLRDILLQGLKAIGSKDDGKLDLSV---------VENGGLKAKTITKKRKKEIEES- 365
Query: 365 HSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQE 405
E E Q E EA Q +R R++ Q+
Sbjct: 366 -KEPGVEDTEWSNTQTE---------EAIQTRSRTRKRVQK 396
>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
Length = 424
Score = 192 bits (489), Expect = 5e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 103 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 160
Query: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 161 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 217
Query: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
Query: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 337
Query: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 338 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 397
Query: 308 ALKKIL------------NPHGIPLGP 322
L+ L +P G+P+ P
Sbjct: 398 MLRNNLEALLQDLRVSPYDPIGLPMVP 424
>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
Length = 474
Score = 192 bits (489), Expect = 5e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 153 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 210
Query: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 211 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 267
Query: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
Query: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 387
Query: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 388 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 447
Query: 308 ALKKIL------------NPHGIPLGP 322
L+ L +P G+P+ P
Sbjct: 448 MLRNNLEALLQDLRVSPYDPIGLPMVP 474
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 123 bits (308), Expect = 5e-28
Identities = 95/294 (32%), Positives = 141/294 (47%), Gaps = 34/294 (11%)
Query: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
GN++ LG+KIGSG FG IYL E+ A + V+ ++ L E KFY+ +
Sbjct: 6 GNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVK-TKHPQLHIESKFYKMMQGG-- 62
Query: 86 IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
+GIP G Y MVME LG L+ + + F TVL
Sbjct: 63 ------------VGIPSIKWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106
Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
L +M+ +EYIH ++H D+K N L+G K + VY+ D+GL+ +Y H+
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166
Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
K GT + S++ H G+ SRR D+E LGY ++ + G LPW Q LK A +
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223
Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
K + E S + K PS E + +L SL +D+KP+Y L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFSTYLNFCRSLRFDDKPDYSYLRQL 272
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 123 bits (308), Expect = 5e-28
Identities = 95/294 (32%), Positives = 141/294 (47%), Gaps = 34/294 (11%)
Query: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
GN++ LG+KIGSG FG IYL E+ A + V+ ++ L E KFY+ +
Sbjct: 6 GNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVK-TKHPQLHIESKFYKMMQGG-- 62
Query: 86 IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
+GIP G Y MVME LG L+ + + F TVL
Sbjct: 63 ------------VGIPSIKWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106
Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
L +M+ +EYIH ++H D+K N L+G K + VY+ D+GL+ +Y H+
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166
Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
K GT + S++ H G+ SRR D+E LGY ++ + G LPW Q LK A +
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223
Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
K + E S + K PS E + +L SL +D+KP+Y L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFSTYLNFCRSLRFDDKPDYSYLRQL 272
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 122 bits (306), Expect = 8e-28
Identities = 95/294 (32%), Positives = 140/294 (47%), Gaps = 34/294 (11%)
Query: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
GN++ LG+KIGSG FG IYL E+ A + V+ ++ L E K Y+ +
Sbjct: 6 GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVK-TKHPQLHIESKIYKMMQGG-- 62
Query: 86 IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
+GIP G Y MVME LG L+ + + F TVL
Sbjct: 63 ------------VGIPTIRWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106
Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
L +M+ +EYIH ++H D+K N L+G K + VY+ D+GL+ +Y H+
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166
Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
K GT + S++ H G+ SRR D+E LGY ++ + G LPW Q LK A +
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223
Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
K + E S + K PS E A +L SL +D+KP+Y L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFATYLNFCRSLRFDDKPDYSYLRQL 272
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 122 bits (306), Expect = 8e-28
Identities = 95/294 (32%), Positives = 140/294 (47%), Gaps = 34/294 (11%)
Query: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85
GN++ LG+KIGSG FG IYL E+ A + V+ ++ L E K Y+ +
Sbjct: 6 GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVK-TKHPQLHIESKIYKMMQGG-- 62
Query: 86 IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVL 144
+GIP G Y MVME LG L+ + + F TVL
Sbjct: 63 ------------VGIPTIRWCGAEG----DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106
Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
L +M+ +EYIH ++H D+K N L+G K + VY+ D+GL+ +Y H+
Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166
Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
K GT + S++ H G+ SRR D+E LGY ++ + G LPW Q LK A +
Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW-QGLK--AATKRQ 223
Query: 264 KTNLLDELPQS-----VLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
K + E S + K PS E A +L SL +D+KP+Y L+++
Sbjct: 224 KYERISEKKMSTPIEVLCKGYPS-----EFATYLNFCRSLRFDDKPDYSYLRQL 272
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 113 bits (282), Expect = 5e-25
Identities = 89/299 (29%), Positives = 142/299 (47%), Gaps = 28/299 (9%)
Query: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
Query: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Query: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRY 193
+ F TVL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y
Sbjct: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 164
Query: 194 CPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
N + K GT + S++AH G+ SRR D+E LGY ++ + LPW Q
Sbjct: 165 RDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QG 223
Query: 254 LKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
LK A + K + E S E A +L L ++E P+Y L+++
Sbjct: 224 LK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 280
>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
Length = 455
Score = 108 bits (269), Expect = 1e-23
Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)
Query: 24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
M G + +GKKIG G FG + L E A +K+E ++ L E +FY+++
Sbjct: 38 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
Query: 82 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
D GIP Y G Y MV+E LG L+ + + TF
Sbjct: 95 SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
TVL + I+++ +EY+H ++ D+K N L+G K +++ D+GL+ Y
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
K K GT + S++ H G SRR D+E LG+ + +L G LPW
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
Q K + L E Q + K A C E+A +L L + EKP+Y L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
Query: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371
+ G + F + I P Q A +AH + + +SA+
Sbjct: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365
Query: 372 SCATWKVQK 380
A W Q+
Sbjct: 366 HRAAWDSQQ 374
>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
Length = 447
Score = 108 bits (269), Expect = 1e-23
Identities = 101/369 (27%), Positives = 154/369 (41%), Gaps = 44/369 (11%)
Query: 24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
M G + +GKKIG G FG + L E A +K+E ++ L E +FY+++
Sbjct: 38 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
Query: 82 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
D GIP Y G Y MV+E LG L+ + + TF
Sbjct: 95 SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
TVL + I+++ +EY+H ++ D+K N L+G K +++ D+GL+ Y
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
K K GT + S++ H G SRR D+E LG+ + +L G LPW
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
Q K + L E Q + K A C E+A +L L + EKP+Y L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
Query: 312 ILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAE 371
+ G + F + I P Q A +AH + + +SA+
Sbjct: 307 LFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSAD 365
Query: 372 SCATWKVQK 380
A W Q+
Sbjct: 366 HRAAWDSQQ 374
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 106 bits (264), Expect = 6e-23
Identities = 85/291 (29%), Positives = 137/291 (47%), Gaps = 28/291 (9%)
Query: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 83
G ++ L +KIGSG FG +YL T E+ A VK+E Q+ + L E K Y +
Sbjct: 14 GGKYKLVRKIGSGSFGDVYLGITTTNGEEVA---VKLESQKVKHPQLLYESKLYTILQGG 70
Query: 84 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 142
+GIP + G + + +VM+ LG L+ + + F T
Sbjct: 71 --------------VGIPHMHWYG----QEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
Query: 143 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 201
VL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y N +
Sbjct: 113 VLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH 172
Query: 202 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 261
K GT+ + S++AH G+ SRR D+E LGY + + LPW Q LK +
Sbjct: 173 IPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW-QGLK--AMTK 229
Query: 262 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
K + E S E A +L L ++E P+Y L+++
Sbjct: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQL 280
>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
Length = 365
Score = 104 bits (259), Expect = 2e-22
Identities = 90/327 (27%), Positives = 141/327 (43%), Gaps = 56/327 (17%)
Query: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
Query: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Query: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG------------------- 175
+ F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS 164
Query: 176 ----------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGV 225
+ +Q++L D+GL+ +Y N + K GT + S++AH G+
Sbjct: 165 MTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI 224
Query: 226 ALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSC 285
SRR D+E LGY ++ + LPW Q LK A + K + E S
Sbjct: 225 EQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFP 281
Query: 286 CEIAQFLVCAHSLAYDEKPNYQALKKI 312
E A +L L ++E P+Y L+++
Sbjct: 282 AEFAMYLNYCRGLRFEEAPDYMYLRQL 308
>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
Length = 415
Score = 103 bits (257), Expect = 4e-22
Identities = 88/301 (29%), Positives = 133/301 (44%), Gaps = 43/301 (14%)
Query: 24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
M G + +GKKIG G FG + L E A +K+E ++ L E +FY+++
Sbjct: 38 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
Query: 82 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
D GIP Y G Y MV+E LG L+ + + TF
Sbjct: 95 SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
TVL + I+++ +EY+H ++ D+K N L+G K +++ D+GL+ Y
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
K K GT + S++ H G SRR D+E LG+ + +L G LPW
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
Q K + L E Q + K A C E+A +L L + EKP+Y L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
Query: 312 I 312
+
Sbjct: 307 L 307
>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
Length = 423
Score = 103 bits (257), Expect = 4e-22
Identities = 88/301 (29%), Positives = 133/301 (44%), Gaps = 43/301 (14%)
Query: 24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVA 81
M G + +GKKIG G FG + L E A +K+E ++ L E +FY+++
Sbjct: 38 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLG 94
Query: 82 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
D GIP Y G Y MV+E LG L+ + + TF
Sbjct: 95 SGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSL 136
Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
TVL + I+++ +EY+H ++ D+K N L+G K +++ D+GL+ Y
Sbjct: 137 KTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPE 196
Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
K K GT + S++ H G SRR D+E LG+ + +L G LPW
Sbjct: 197 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 249
Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKK 311
Q K + L E Q + K A C E+A +L L + EKP+Y L+K
Sbjct: 250 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 306
Query: 312 I 312
+
Sbjct: 307 L 307
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 100 bits (250), Expect = 2e-21
Identities = 86/290 (29%), Positives = 135/290 (46%), Gaps = 33/290 (11%)
Query: 27 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 86
++W + KKIG GGFG IY A E A V + Q L E+ +++ KD +
Sbjct: 32 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHV 90
Query: 87 KKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVL 144
++I G G E + ++VM+ G +L + S GTF ST L
Sbjct: 91 CRFI--------------GCGRNE----KFNYVVMQLQGRNLADLRRSQPRGTFTLSTTL 132
Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQY 202
+LG ++L+ +E IH ++H DIK +N +G + Y+ D+GL+ +Y +
Sbjct: 133 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRP 192
Query: 203 QENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQT 262
N G GT+ + S++AHK + R D+ L Y ++ + G+LPW + +KD V
Sbjct: 193 PRNV-AGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW-RKIKDKEQVGM 250
Query: 263 AKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
K + +LK PS E FL SL Y KP+YQ + +
Sbjct: 251 IKEKYEHRM---LLKHMPS-----EFHLFLDHIASLDYFTKPDYQLIMSV 292
>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
Length = 415
Score = 100 bits (248), Expect = 4e-21
Identities = 87/302 (28%), Positives = 134/302 (44%), Gaps = 44/302 (14%)
Query: 24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE-YQENGP-LFSELKFYQRVA 81
M G + +GKKIG G FG + L E A +K+E + P L E +FY++++
Sbjct: 41 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHLEYRFYKQLS 97
Query: 82 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
+ G+P Y G Y MV+E LG L+ + + TF
Sbjct: 98 ATE--------------GVPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFTL 139
Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
TVL + I+++ +EY+H ++ D+K N L+G K +++ D+GL+ Y
Sbjct: 140 KTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPE 199
Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
K K GT + S++ H G SRR D+E LG+ + +L G LPW
Sbjct: 200 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 252
Query: 258 VAVQTAKTNLLDELPQSV--LKWAPSGSSCC-----EIAQFLVCAHSLAYDEKPNYQALK 310
Q K + L E Q + K A C E+A +L L + EKP+Y L+
Sbjct: 253 ---QGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLR 309
Query: 311 KI 312
K+
Sbjct: 310 KL 311
>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
Length = 422
Score = 97.4 bits (241), Expect = 3e-20
Identities = 96/348 (27%), Positives = 149/348 (42%), Gaps = 45/348 (12%)
Query: 24 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE-YQENGP-LFSELKFYQRVA 81
M G + +GKKIG G FG + L E A +K+E + P L E +FY+++
Sbjct: 39 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHLEYRFYKQLG 95
Query: 82 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKK 140
G+P Y G Y MV+E LG L+ + + TF
Sbjct: 96 SAG-------------EGLPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFTL 138
Query: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNG 197
TVL + I++L +EY+H ++ D+K N L+G K +++ D+GL+ Y
Sbjct: 139 KTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPE 198
Query: 198 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 257
K K GT + S++ H G SRR D+E LG+ + +L G LPW
Sbjct: 199 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW------- 251
Query: 258 VAVQTAKTNLLDELPQSV---LKWAPSGSSC----CEIAQFLVCAHSLAYDEKPNYQALK 310
Q K + L E Q + + P + C E+A +L L + EKP+Y+ L+
Sbjct: 252 ---QGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLR 308
Query: 311 KILNPHGIPLG-PLDFSTKGQSINVHTP-NSQKVDSQKAATKQVNKAH 356
+ G D++ + TP S VDS +A + + H
Sbjct: 309 TLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTH 356
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 95.9 bits (237), Expect = 8e-20
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 33/291 (11%)
Query: 28 QWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIK 87
+W + +KIG GGFG IY A E A V + Q L E+ +++ KD +
Sbjct: 20 RWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQ-QPKQVLKMEVAVLKKLQGKDHVC 78
Query: 88 KWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKSTVLQ 145
++I G G + + ++VM+ G +L + S GTF ST L+
Sbjct: 79 RFI--------------GCGRND----RFNYVVMQLQGRNLADLRRSQSRGTFTISTTLR 120
Query: 146 LGIRMLDVLEYIHENEYVHGDIKAANLLLGY--KNPDQVYLADYGLSYRYCPNGNHKQYQ 203
LG ++L+ +E IH ++H DIK +N +G + Y+ D+GL+ R N
Sbjct: 121 LGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLA-RQFTNSCGDVRP 179
Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA 263
G GT+ + S++AH+ + R D+ L Y ++ ++ G+LPW + +KD V +
Sbjct: 180 PRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW-RKIKDKEQVGSI 238
Query: 264 KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILN 314
K L +LK P E + FL SL Y KP+YQ L + +
Sbjct: 239 KERYDHRL---MLKHLPP-----EFSIFLDHISSLDYFTKPDYQLLTSVFD 281
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/227 (25%), Positives = 97/227 (42%), Gaps = 17/227 (7%)
Query: 25 EGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKD 84
E +W+ G++IG G F Y A A V +V Y N SE + ++
Sbjct: 1239 EDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMA--VKQVTYVRNTS--SEQEEVVEALRE- 1293
Query: 85 CIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVL 144
E + + +L P + +Y + G + + + G FK+S V+
Sbjct: 1294 ------EIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVI 1347
Query: 145 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK-QYQ 203
++L L Y+HEN+ +H D+K ANLL+ ++ +AD+G + R G ++Q
Sbjct: 1348 NYTEQLLRGLSYLHENQIIHRDVKGANLLID-STGQRLRIADFGAAARLASKGTGAGEFQ 1406
Query: 204 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW 250
GTI F + + +G R DV +G ++ C K PW
Sbjct: 1407 GQLL----GTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPW 1449
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 58.5 bits (140), Expect = 1e-08
Identities = 57/227 (25%), Positives = 98/227 (43%), Gaps = 22/227 (9%)
Query: 29 WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKK 88
W GK +G G FG +YL + + + A +V++ + P S+ V+ +C +
Sbjct: 393 WRRGKLLGQGAFGRVYLCYDVDTGRELASK--QVQFDPDSPETSK-----EVSALECEIQ 445
Query: 89 WIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGI 148
+ K L + I +YG L + ++ + G ++ G +S +
Sbjct: 446 LL--KNLQHERIVQYYGC-LRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR 502
Query: 149 RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR---YCPNGNHKQYQEN 205
++L+ + Y+H N VH DIK AN+L + V L D+G S R C +G
Sbjct: 503 QILEGMSYLHSNMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQTICMSG-------T 553
Query: 206 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 252
+ GT + S + G R++DV LG ++ L K PW +
Sbjct: 554 GMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 600
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 58.5 bits (140), Expect = 1e-08
Identities = 57/227 (25%), Positives = 98/227 (43%), Gaps = 22/227 (9%)
Query: 29 WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKK 88
W GK +G G FG +YL + + + A +V++ + P S+ V+ +C +
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASK--QVQFDPDSPETSK-----EVSALECEIQ 414
Query: 89 WIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGI 148
+ K L + I +YG L + ++ + G ++ G +S +
Sbjct: 415 LL--KNLQHERIVQYYGC-LRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR 471
Query: 149 RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR---YCPNGNHKQYQEN 205
++L+ + Y+H N VH DIK AN+L + V L D+G S R C +G
Sbjct: 472 QILEGMSYLHSNMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQTICMSG-------T 522
Query: 206 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 252
+ GT + S + G R++DV LG ++ L K PW +
Sbjct: 523 GMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 569
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 55.8 bits (133), Expect = 9e-08
Identities = 56/227 (24%), Positives = 99/227 (43%), Gaps = 22/227 (9%)
Query: 29 WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKK 88
W LGK +G G FG +YL + + + A V +V++ + P S+ V +C +
Sbjct: 356 WRLGKLLGQGAFGRVYLCYDVDTGRELA--VKQVQFDPDSPETSK-----EVNALECEIQ 408
Query: 89 WIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGI 148
+ K L + I +YG L + + ++ + G ++ G ++ +
Sbjct: 409 LL--KNLLHERIVQYYGC-LRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTR 465
Query: 149 RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR---YCPNGNHKQYQEN 205
++L+ + Y+H N VH DIK AN+L + V L D+G S R C +G
Sbjct: 466 QILEGVHYLHSNMIVHRDIKGANIL--RDSTGNVKLGDFGASKRLQTICLSG-------T 516
Query: 206 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 252
K GT + S + G R++D+ + ++ L K PW +
Sbjct: 517 GMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAE 563
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 55.8 bits (133), Expect = 9e-08
Identities = 67/225 (29%), Positives = 107/225 (47%), Gaps = 29/225 (12%)
Query: 33 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 92
K IG G FG YLA K + D++H V E F ++ ++ A K K+ I
Sbjct: 8 KAIGQGAFGKAYLA----KGKSDSKHCVIKEIN-----FEKMPIQEKEASK---KEVILL 55
Query: 93 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQK-ISGQNGT-FKKSTVLQLGIR 149
+++ + I F+ S F+ F+VME G DL K I+ Q G F + +L ++
Sbjct: 56 EKMKHPNIVAFFNS----FQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQ 111
Query: 150 MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKG 209
+ L++IH+ + +H DIKA N+ L KN L D+G++ R N +
Sbjct: 112 ISLGLKHIHDRKILHRDIKAQNIFLS-KNGMVAKLGDFGIA-RVLNNSMEL------ART 163
Query: 210 HNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCG-KLPWEQN 253
GT + S + + + ++D+ LG C+L LC K P+E N
Sbjct: 164 CIGTPYYLSPEICQNKPYNNKTDIWSLG-CVLYELCTLKHPFEGN 207
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 53.1 bits (126), Expect = 6e-07
Identities = 63/273 (23%), Positives = 116/273 (42%), Gaps = 52/273 (19%)
Query: 2 PPKRNEKYKLPIPF-----PEGKVL-----DDMEGNQWVL-----GKKIGSGGFGLIYLA 46
P +K K P+P PE ++ ++ + QW L G+ +G G FG +YLA
Sbjct: 91 PLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLA 150
Query: 47 FPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIE-RKQLDYLGIPLFYG 105
EK ++ ++ ++ L ++ + +++ +E + L + I YG
Sbjct: 151 -----REKQSKFILALKVLFKAQL-------EKAGVEHQLRREVEIQSHLRHPNILRLYG 198
Query: 106 SGLTEFKGRSYRFMVMERLGI-----DLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHEN 160
F + ++++E + +LQK+S F + + + L Y H
Sbjct: 199 Y----FHDATRVYLILEYAPLGTVYRELQKLS----KFDEQRTATYITELANALSYCHSK 250
Query: 161 EYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLD 220
+H DIK NLLLG + ++ +AD+G S + P+ R GT+++ +
Sbjct: 251 RVIHRDIKPENLLLG--SAGELKIADFGWSV-HAPSSR--------RTTLCGTLDYLPPE 299
Query: 221 AHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 253
+G + D+ LG +L GK P+E N
Sbjct: 300 MIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,973,942
Number of Sequences: 37866
Number of extensions: 916302
Number of successful extensions: 3402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 356
Number of HSP's that attempted gapping in prelim test: 2863
Number of HSP's gapped (non-prelim): 725
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.