Search of human proteins with 71040098

Search of human proteins with 71040098

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
         (1101 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap...  2217   0.0  
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap...  1365   0.0  
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]           358   2e-98
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]   346   6e-95
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]    346   6e-95
gi|23510413 sorting nexin 26 [Homo sapiens]                           315   1e-85
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           125   2e-28
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...   123   8e-28
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...   123   8e-28
gi|188497642 ARHGAP15 [Homo sapiens]                                  121   3e-27
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          119   2e-26
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            119   2e-26
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          119   2e-26
gi|229094128 active breakpoint cluster region-related  protein i...   116   1e-25
gi|38679957 active breakpoint cluster region-related  protein is...   116   1e-25
gi|38679954 active breakpoint cluster region-related  protein is...   116   1e-25
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     112   3e-24
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    112   3e-24
gi|54860105 nadrin isoform 2 [Homo sapiens]                           107   6e-23
gi|5803145 ralA binding protein 1 [Homo sapiens]                      107   8e-23
gi|54860079 nadrin isoform 1 [Homo sapiens]                           107   8e-23
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s...   103   7e-22
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap...   103   1e-21
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]       103   1e-21
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap...   103   1e-21
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...   102   3e-21
gi|91208437 GEM interacting protein [Homo sapiens]                    102   3e-21
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]               101   3e-21
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]        101   4e-21
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]        101   4e-21

>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sapiens]
          Length = 1101

 Score = 2217 bits (5744), Expect = 0.0
 Identities = 1101/1101 (100%), Positives = 1101/1101 (100%)

Query: 1    MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60
            MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
Sbjct: 1    MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60

Query: 61   SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
            SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
Sbjct: 61   SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120

Query: 121  QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
            QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
Sbjct: 121  QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180

Query: 181  KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240
            KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
Sbjct: 181  KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240

Query: 241  PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300
            PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
Sbjct: 241  PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300

Query: 301  ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360
            ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
Sbjct: 301  ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360

Query: 361  ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420
            ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
Sbjct: 361  ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420

Query: 421  PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480
            PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
Sbjct: 421  PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480

Query: 481  PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540
            PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
Sbjct: 481  PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540

Query: 541  FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600
            FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
Sbjct: 541  FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600

Query: 601  EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660
            EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
Sbjct: 601  EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660

Query: 661  KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS 720
            KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
Sbjct: 661  KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS 720

Query: 721  KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE 780
            KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
Sbjct: 721  KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE 780

Query: 781  EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES 840
            EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
Sbjct: 781  EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES 840

Query: 841  GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP 900
            GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
Sbjct: 841  GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP 900

Query: 901  EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA 960
            EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
Sbjct: 901  EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA 960

Query: 961  PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT 1020
            PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
Sbjct: 961  PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT 1020

Query: 1021 CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL 1080
            CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
Sbjct: 1021 CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL 1080

Query: 1081 SSQRRSYAFETQANPGKGEGL 1101
            SSQRRSYAFETQANPGKGEGL
Sbjct: 1081 SSQRRSYAFETQANPGKGEGL 1101


>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
           sapiens]
          Length = 890

 Score = 1365 bits (3534), Expect = 0.0
 Identities = 678/680 (99%), Positives = 680/680 (100%)

Query: 1   MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60
           MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
Sbjct: 1   MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60

Query: 61  SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
           SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
Sbjct: 61  SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120

Query: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
           QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
Sbjct: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180

Query: 181 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240
           KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
Sbjct: 181 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240

Query: 241 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300
           PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
Sbjct: 241 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300

Query: 301 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360
           ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
Sbjct: 301 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360

Query: 361 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420
           ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
Sbjct: 361 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420

Query: 421 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480
           PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
Sbjct: 421 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480

Query: 481 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540
           PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
Sbjct: 481 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540

Query: 541 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600
           FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
Sbjct: 541 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600

Query: 601 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660
           EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
Sbjct: 601 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660

Query: 661 KQAEPGGRLDIREEAEGSPE 680
           KQAEPGGRLDIREEAEG+P+
Sbjct: 661 KQAEPGGRLDIREEAEGTPQ 680



 Score =  446 bits (1146), Expect = e-125
 Identities = 226/266 (84%), Positives = 229/266 (86%), Gaps = 9/266 (3%)

Query: 841  GDGEAEGDQRAGGYYLEEDTLSEGSGV-ASLEVDCAKEGNPHSS----EMEEVAPQPPQP 895
            G G  EG+    G       L +G    A  EV   K+  P       E  E  PQPPQP
Sbjct: 629  GSGSLEGEAAGCG----RQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGTPQPPQP 684

Query: 896  EEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCS 955
            EEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCS
Sbjct: 685  EEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCS 744

Query: 956  KIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGV 1015
            KIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGV
Sbjct: 745  KIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGV 804

Query: 1016 RRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQV 1075
            RRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQV
Sbjct: 805  RRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQV 864

Query: 1076 PDPLLSSQRRSYAFETQANPGKGEGL 1101
            PDPLLSSQRRSYAFETQANPGKGEGL
Sbjct: 865  PDPLLSSQRRSYAFETQANPGKGEGL 890


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score =  358 bits (919), Expect = 2e-98
 Identities = 195/359 (54%), Positives = 249/359 (69%), Gaps = 20/359 (5%)

Query: 3   SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62
           ++QK K+KG+A    FGCDL E+L+ SGQ+VP VLKSCAEF+E +G+VDGIYRLSGV+SN
Sbjct: 6   AKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSN 63

Query: 63  IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122
           IQ+LRQEF S++ PDL R+VYLQDIHCV SLCK YFRELP+PLLTY LY+KF EAV    
Sbjct: 64  IQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCP 123

Query: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
           E  +L +I  V++ELP  +YRTLE+L+RHL H+ASFS++TNMHARNLA+VWAPNLLRSK+
Sbjct: 124 EEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKE 183

Query: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAA---LSGGEVESGWRSLPGTRAS- 238
           IEA+G NG AAF+ VRVQ +V+EFIL HVDQ+F   A   L   E     +SL     S 
Sbjct: 184 IEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSL 243

Query: 239 ----GSPEDLMPRPLPYHLPSILQAGDG------PPQMRPYHTIIEIAEHKRKGSLKVRK 288
                S E+   R L  + P+  +  +       PP    +HT++E+ ++KRK S K +K
Sbjct: 244 PMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKK 303

Query: 289 WRSIFNLGRSGHETKRKLPRG----AEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEG 343
           W+SIFNLGRSG ++K KL R        +     K T+RPAKSMDSL +      E +G
Sbjct: 304 WKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKETKG 362



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 13/31 (41%), Positives = 23/31 (74%)

Query: 926  STLVQVQQVRSVPVVPPKPQFAKMPSAMCSK 956
            S +V++ Q R+VPV+PPK Q+ ++P  + S+
Sbjct: 1189 SFMVKMCQARAVPVIPPKIQYTQIPQPLPSQ 1219


>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
          Length = 2087

 Score =  346 bits (888), Expect = 6e-95
 Identities = 200/383 (52%), Positives = 256/383 (66%), Gaps = 31/383 (8%)

Query: 1   MKSR---QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLS 57
           MKSR   QK K++G  KERVFGCDL EHL +SG EVPQVL+SC  F+E YG+VDGIYRLS
Sbjct: 350 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 409

Query: 58  GVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEA 117
           GV+SNIQ+LR EF+SE  PDL ++ Y+QDIH V SLCK YFRELP+PLLTY+LY+KF++A
Sbjct: 410 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 469

Query: 118 VGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNL 177
           V    + ERL+KI +V+++LP P+YRTLEFLMRHL  +A + + TNMHA+NLAIVWAPNL
Sbjct: 470 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 529

Query: 178 LRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGG--------AALSGGEVESGW 229
           LRSK IE++ F+GTAAFMEVR+QS+VVEFIL HVD LF G         A S    +S  
Sbjct: 530 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 589

Query: 230 RSLPGTRASGSPEDLMPRPLPYHLPSI-----LQAGDGPPQMR-PYHTIIEIAEHKRKGS 283
            S P T+     E         + P +     ++ G+GP  ++  +HTIIE    +++  
Sbjct: 590 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 649

Query: 284 LKVRK-----WRSIFNLGRSGHETKRKLPRG-AEDREDKS-------NKGTLRPAKSMDS 330
            K++K     WRS FNLG+S   +KRKL R  +E  E K+        +GTLR AKS +S
Sbjct: 650 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 709

Query: 331 LSAAAGASDEPEGLVGPSSPRPS 353
           L+ +  A D    L  P  PR S
Sbjct: 710 LT-SLHAVDGDSKLFRPRRPRSS 731


>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
          Length = 1738

 Score =  346 bits (888), Expect = 6e-95
 Identities = 200/383 (52%), Positives = 256/383 (66%), Gaps = 31/383 (8%)

Query: 1   MKSR---QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLS 57
           MKSR   QK K++G  KERVFGCDL EHL +SG EVPQVL+SC  F+E YG+VDGIYRLS
Sbjct: 1   MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 60

Query: 58  GVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEA 117
           GV+SNIQ+LR EF+SE  PDL ++ Y+QDIH V SLCK YFRELP+PLLTY+LY+KF++A
Sbjct: 61  GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 120

Query: 118 VGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNL 177
           V    + ERL+KI +V+++LP P+YRTLEFLMRHL  +A + + TNMHA+NLAIVWAPNL
Sbjct: 121 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 180

Query: 178 LRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGG--------AALSGGEVESGW 229
           LRSK IE++ F+GTAAFMEVR+QS+VVEFIL HVD LF G         A S    +S  
Sbjct: 181 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 240

Query: 230 RSLPGTRASGSPEDLMPRPLPYHLPSI-----LQAGDGPPQMR-PYHTIIEIAEHKRKGS 283
            S P T+     E         + P +     ++ G+GP  ++  +HTIIE    +++  
Sbjct: 241 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 300

Query: 284 LKVRK-----WRSIFNLGRSGHETKRKLPRG-AEDREDKS-------NKGTLRPAKSMDS 330
            K++K     WRS FNLG+S   +KRKL R  +E  E K+        +GTLR AKS +S
Sbjct: 301 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 360

Query: 331 LSAAAGASDEPEGLVGPSSPRPS 353
           L+ +  A D    L  P  PR S
Sbjct: 361 LT-SLHAVDGDSKLFRPRRPRSS 382


>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score =  315 bits (808), Expect = 1e-85
 Identities = 186/369 (50%), Positives = 237/369 (64%), Gaps = 16/369 (4%)

Query: 3   SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62
           SRQ+ +++G  ++RVFGCDL EHL +SGQ+VPQVL+ C+EF+E +GVVDGIYRLSGVSSN
Sbjct: 298 SRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSN 357

Query: 63  IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122
           IQ+LR EF+SER P+L    +LQDIH VSSLCK YFRELP+PLLTY+LY KF+EA+ V  
Sbjct: 358 IQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPG 417

Query: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
           E ERLV++ +V+++LP P+YRTLE+L+RHL  MA  SA T+MHARNLAIVWAPNLLRS +
Sbjct: 418 EEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSME 477

Query: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRA-SGSP 241
           +E+ G  G AAF EVRVQS+VVEF+LTHVD LF     S G   +G   LP  ++ +GS 
Sbjct: 478 LESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSC 537

Query: 242 EDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSL--KVRK-----WRSIFN 294
                  L     +  Q   G P              +RKG    K RK     W++ F 
Sbjct: 538 PSTRLLTLE-EAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFA 596

Query: 295 LGRSGHETKRK-LPRGAEDREDKSNKG------TLRPAKSMDSLSAAAGASDEPEGLVGP 347
           LGR     ++K LP     R      G      TLR AKS +SLS+ A  ++       P
Sbjct: 597 LGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAP 656

Query: 348 SSPRPSPLL 356
           +S  P+P L
Sbjct: 657 ASATPTPAL 665


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  125 bits (315), Expect = 2e-28
 Identities = 78/214 (36%), Positives = 122/214 (57%), Gaps = 11/214 (5%)

Query: 5   QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
           Q  ++KG  K++VFG +L    Q     VP+ +K C E VEE+G+ +DGIYR+SG  + I
Sbjct: 641 QAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVI 700

Query: 64  QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
           QKLR     + K DL  D   +DIH ++   K +FRELP+PL T+  ++ F  A+  + E
Sbjct: 701 QKLRFAVNHDEKLDLN-DSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAI--KQE 757

Query: 124 P-ERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
           P +R+  + +++R+LP PN  T++ L RHL  +     +  M  +++AIV+ P LL+ + 
Sbjct: 758 PRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEK 817

Query: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216
                  G  A   V  Q+ +VE IL  +  +FG
Sbjct: 818 -----ETGNIAVHTV-YQNQIVELILLELSSIFG 845


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score =  123 bits (309), Expect = 8e-28
 Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)

Query: 5   QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
           Q  ++KG  K++VFGC L    +     VP+ ++ C   VE  G+ +DG+YR+SG  + I
Sbjct: 314 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 373

Query: 64  QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
           QKLR + + + + DL  D   +D+H ++   K +FRELP+PL  +  + +F  A+ +Q +
Sbjct: 374 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 432

Query: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
             R   + +++R LP PN+ TL  L +HL  +     Q  M  +++AIV+ P LLR  ++
Sbjct: 433 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 491

Query: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
           E +    T  F     Q+ VVE IL     +F
Sbjct: 492 EETSMPMTMVF-----QNQVVELILQQCADIF 518


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score =  123 bits (309), Expect = 8e-28
 Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)

Query: 5   QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
           Q  ++KG  K++VFGC L    +     VP+ ++ C   VE  G+ +DG+YR+SG  + I
Sbjct: 341 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 400

Query: 64  QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
           QKLR + + + + DL  D   +D+H ++   K +FRELP+PL  +  + +F  A+ +Q +
Sbjct: 401 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 459

Query: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
             R   + +++R LP PN+ TL  L +HL  +     Q  M  +++AIV+ P LLR  ++
Sbjct: 460 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 518

Query: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
           E +    T  F     Q+ VVE IL     +F
Sbjct: 519 EETSMPMTMVF-----QNQVVELILQQCADIF 545


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  121 bits (304), Expect = 3e-27
 Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 8/210 (3%)

Query: 8   KKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKL 66
           ++KG  K+++FG  L +  +     VP  +K C E VE+ G+ VDGIYR+SG  + IQKL
Sbjct: 269 QEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKL 328

Query: 67  RQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPER 126
           R     E K +L  D   +DIH V+   K +FRELP+PL  Y  +++F EA+  Q    R
Sbjct: 329 RFIVNQEEKLNLD-DSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTR 387

Query: 127 LVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEAS 186
           +  +  ++++LP PN  T++ L  HL  + + +++  M  ++L IV+ P LLR     A 
Sbjct: 388 IEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR-----AE 442

Query: 187 GFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216
              G  A   V  Q+ + E +L+   ++FG
Sbjct: 443 NETGNMAIHMV-YQNQIAELMLSEYSKIFG 471


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  119 bits (298), Expect = 2e-26
 Identities = 119/413 (28%), Positives = 187/413 (45%), Gaps = 44/413 (10%)

Query: 8    KKKGSAKERVFGCDLQE-HLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
            KK   A  R FG  L+E       Q VP ++ +C   VE  G+   GIYR+ G ++ +  
Sbjct: 799  KKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSS 858

Query: 66   LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
            L+++          +D   QD++ +SSL K++FR+LP+PL T   Y+ F EA  ++   E
Sbjct: 859  LQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARE 918

Query: 126  RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
            R+  + +++R+LP   Y TL+FL+ HL  +A  S +  M  RNLA+V+ P L+R+     
Sbjct: 919  RMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRT----- 973

Query: 186  SGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLM 245
            S  N T     +  +  +VE ++ H D  F        E + G R+  G        D  
Sbjct: 974  SEDNMTDMVTHMPDRYKIVETLIQHSDWFF------SDEEDKGERTPVG--------DKE 1019

Query: 246  PRPLP---YHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRK---WRSIFNLG-RS 298
            P+ +P   Y LP+I   G   P   P       +  K KGS   +K    R +  +   S
Sbjct: 1020 PQAVPNIEYLLPNI---GRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFIS 1076

Query: 299  GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE 358
                KRK  R A      ++  + + A    + + A G  + P+G      P P  + PE
Sbjct: 1077 AVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQG------PLPGAVAPE 1130

Query: 359  SLENDSIEAAEGEQEPEAEA---LGGTNSEPGTPR---AGRSAIRAGGSSRAE 405
            +    S  AA  E+ P A+    + G ++     R   +G S  RAG    A+
Sbjct: 1131 APGRLSPPAAP-EERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEAD 1182


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  119 bits (298), Expect = 2e-26
 Identities = 69/203 (33%), Positives = 116/203 (57%), Gaps = 8/203 (3%)

Query: 15  ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFESE 73
           ++V+ CDL   ++    + P V+  C   +E  G+  +G+YR+SG S  I+ ++  F+ +
Sbjct: 263 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 322

Query: 74  -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
             K D+  ++Y +DI+ ++   K YFR+LP PL+TY  Y KF E+  +    E+L  + E
Sbjct: 323 GEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHE 381

Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
            L+ LP  +  TL +LM HL  +     +  M+A NL IV+ P L+RS +++A      A
Sbjct: 382 ALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDA-----MA 436

Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
           A  ++R Q +VVE ++ + D LF
Sbjct: 437 ALNDIRYQRLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  119 bits (298), Expect = 2e-26
 Identities = 69/203 (33%), Positives = 116/203 (57%), Gaps = 8/203 (3%)

Query: 15  ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFESE 73
           ++V+ CDL   ++    + P V+  C   +E  G+  +G+YR+SG S  I+ ++  F+ +
Sbjct: 237 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 296

Query: 74  -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
             K D+  ++Y +DI+ ++   K YFR+LP PL+TY  Y KF E+  +    E+L  + E
Sbjct: 297 GEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHE 355

Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
            L+ LP  +  TL +LM HL  +     +  M+A NL IV+ P L+RS +++A      A
Sbjct: 356 ALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDA-----MA 410

Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
           A  ++R Q +VVE ++ + D LF
Sbjct: 411 ALNDIRYQRLVVELLIKNEDILF 433


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score =  116 bits (291), Expect = 1e-25
 Identities = 74/214 (34%), Positives = 117/214 (54%), Gaps = 7/214 (3%)

Query: 3   SRQKGKKKGSAKER--VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGV 59
           SR    K+  +K++  VFG  +    +    +VP +++ C E VE+ G+ + GIYR+SGV
Sbjct: 582 SRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGV 641

Query: 60  SSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVG 119
           +++IQ L+  F++  K D+   +   DI+ ++   K YFRELP+PLLT RLY  F E + 
Sbjct: 642 ATDIQALKAVFDANNK-DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA 700

Query: 120 VQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLR 179
           +     +   ++ +LR LP PN  T  FL+ HL  +A       M   NLA V+ P LLR
Sbjct: 701 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR 760

Query: 180 SKDIEASGFNGTAAFM---EVRVQSIVVEFILTH 210
             ++E+     +AA +   +V  Q  V+ + L H
Sbjct: 761 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 794


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score =  116 bits (291), Expect = 1e-25
 Identities = 74/214 (34%), Positives = 117/214 (54%), Gaps = 7/214 (3%)

Query: 3   SRQKGKKKGSAKER--VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGV 59
           SR    K+  +K++  VFG  +    +    +VP +++ C E VE+ G+ + GIYR+SGV
Sbjct: 628 SRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGV 687

Query: 60  SSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVG 119
           +++IQ L+  F++  K D+   +   DI+ ++   K YFRELP+PLLT RLY  F E + 
Sbjct: 688 ATDIQALKAVFDANNK-DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA 746

Query: 120 VQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLR 179
           +     +   ++ +LR LP PN  T  FL+ HL  +A       M   NLA V+ P LLR
Sbjct: 747 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR 806

Query: 180 SKDIEASGFNGTAAFM---EVRVQSIVVEFILTH 210
             ++E+     +AA +   +V  Q  V+ + L H
Sbjct: 807 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 840


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score =  116 bits (291), Expect = 1e-25
 Identities = 74/214 (34%), Positives = 117/214 (54%), Gaps = 7/214 (3%)

Query: 3   SRQKGKKKGSAKER--VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGV 59
           SR    K+  +K++  VFG  +    +    +VP +++ C E VE+ G+ + GIYR+SGV
Sbjct: 591 SRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGV 650

Query: 60  SSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVG 119
           +++IQ L+  F++  K D+   +   DI+ ++   K YFRELP+PLLT RLY  F E + 
Sbjct: 651 ATDIQALKAVFDANNK-DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA 709

Query: 120 VQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLR 179
           +     +   ++ +LR LP PN  T  FL+ HL  +A       M   NLA V+ P LLR
Sbjct: 710 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR 769

Query: 180 SKDIEASGFNGTAAFM---EVRVQSIVVEFILTH 210
             ++E+     +AA +   +V  Q  V+ + L H
Sbjct: 770 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 803


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  112 bits (279), Expect = 3e-24
 Identities = 65/203 (32%), Positives = 110/203 (54%), Gaps = 8/203 (3%)

Query: 15  ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVV-DGIYRLSGVSSNIQKLRQEFESE 73
           ++V+ CDL   ++    + P V+  C   +E  G+  +G+YR+SG + +I+ ++  F+ +
Sbjct: 272 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 331

Query: 74  -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
             K D+  +VY  DI+ ++   K YFR+LP P++TY  Y KF +A  +    ERL  + E
Sbjct: 332 GEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE 390

Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
           VL  LP  +Y TL +LM HL  +        M+A NL IV+ P L+R  +          
Sbjct: 391 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDST-----LT 445

Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
              ++R Q ++V+ ++ + D LF
Sbjct: 446 TLHDMRYQKLIVQILIENEDVLF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  112 bits (279), Expect = 3e-24
 Identities = 65/203 (32%), Positives = 110/203 (54%), Gaps = 8/203 (3%)

Query: 15  ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVV-DGIYRLSGVSSNIQKLRQEFESE 73
           ++V+ CDL   ++    + P V+  C   +E  G+  +G+YR+SG + +I+ ++  F+ +
Sbjct: 136 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 195

Query: 74  -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
             K D+  +VY  DI+ ++   K YFR+LP P++TY  Y KF +A  +    ERL  + E
Sbjct: 196 GEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE 254

Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
           VL  LP  +Y TL +LM HL  +        M+A NL IV+ P L+R  +          
Sbjct: 255 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDST-----LT 309

Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
              ++R Q ++V+ ++ + D LF
Sbjct: 310 TLHDMRYQKLIVQILIENEDVLF 332


>gi|54860105 nadrin isoform 2 [Homo sapiens]
          Length = 803

 Score =  107 bits (267), Expect = 6e-23
 Identities = 128/523 (24%), Positives = 200/523 (38%), Gaps = 95/523 (18%)

Query: 13  AKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFE 71
           A++  FG  L+EHL+ SG+E+   +++C   + E G+ + G++R+   +S ++KL+   +
Sbjct: 245 AEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALD 304

Query: 72  SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131
                    D +  D H V+   K+Y RELP+PL+T+ LY+++ +   VQ + ++L  + 
Sbjct: 305 CSTS---HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLW 361

Query: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191
              ++LP  N+    +L++ L  +A  S    M   N+AIV  PNLL +++       GT
Sbjct: 362 RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN------EGT 415

Query: 192 AAFMEVRVQ---SIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRP 248
            A M          V+E I+ H D  F                              P  
Sbjct: 416 LAEMAAATSVHVVAVIEPIIQHADWFF------------------------------PEE 445

Query: 249 LPYHLPSILQAGDGPPQMRPYHTIIE----IAEHKRKGSLKVRKWRSIFNLGRSGHETKR 304
           + +++         P     +HT  +      E KR  S+ V +     +L +     K 
Sbjct: 446 VEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEG----DLVKKESPPKP 501

Query: 305 KLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASD----EPEGLVGPS---------SPR 351
           K P  A       N   +  A   +   AAAG+      +P    GPS          P 
Sbjct: 502 KDPVSAAVPAPGRNNSQI--ASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPA 559

Query: 352 PSPLLP----------ESLENDSIEAAEGEQEPEAEA----LGGTNSEPGTPRAGR--SA 395
           P+P  P          +S    S        +P   +       T   PG P A    SA
Sbjct: 560 PAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSA 619

Query: 396 IRAGGSSRAERCAGVH--ISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQ 453
            R   SS +   A  H     P      +H       PPN ++  S      GLE P+  
Sbjct: 620 PRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPS----EHGLEQPS-- 673

Query: 454 HRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAP 496
           H P     P   P LG   P     + PA   LA   P+   P
Sbjct: 674 HTPPQTPTPPSTPPLGKQNP-----SLPAPQTLAGGNPETAQP 711


>gi|5803145 ralA binding protein 1 [Homo sapiens]
          Length = 655

 Score =  107 bits (266), Expect = 8e-23
 Identities = 63/209 (30%), Positives = 111/209 (53%), Gaps = 29/209 (13%)

Query: 17  VFGCDLQEHLQ----HSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFE 71
           +FG  L + ++    + G  +P V + C ++VE+YG+  +GIYR+SG+ S + +L+  ++
Sbjct: 189 IFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYD 248

Query: 72  SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131
            E   +L       + + V+SL K Y R+LP+ LLT  L  +F EA G   E E++ +  
Sbjct: 249 REESTNLED----YEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQ 304

Query: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191
            +L+ELP  NY  + +L+ H+ H+ +   +T M+ +N++IV +P                
Sbjct: 305 RLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPT--------------- 349

Query: 192 AAFMEVRVQSIVVEFILTHVDQLFGGAAL 220
                V++ + V+    THV +LFG   L
Sbjct: 350 -----VQISNRVLYVFFTHVQELFGNVVL 373


>gi|54860079 nadrin isoform 1 [Homo sapiens]
          Length = 881

 Score =  107 bits (266), Expect = 8e-23
 Identities = 94/383 (24%), Positives = 171/383 (44%), Gaps = 36/383 (9%)

Query: 13  AKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFE 71
           A++  FG  L+EHL+ SG+E+   +++C   + E G+ + G++R+   +S ++KL+   +
Sbjct: 245 AEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALD 304

Query: 72  SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131
                    D +  D H V+   K+Y RELP+PL+T+ LY+++ +   VQ + ++L  + 
Sbjct: 305 CSTS---HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLW 361

Query: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191
              ++LP  N+    +L++ L  +A  S    M   N+AIV  PNLL +++       GT
Sbjct: 362 RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN------EGT 415

Query: 192 AAFMEVRVQ---SIVVEFILTHVDQLFGGAA---LSGGEVESGWRSLPGTRASGSPED-- 243
            A M          V+E I+ H D  F       +S   V     S   +  +G+  D  
Sbjct: 416 LAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSG 475

Query: 244 LMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETK 303
            + R  P  +   +  GD   +      +++   H+R G+L  +     F       +  
Sbjct: 476 TLERKRPASM--AVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGS 533

Query: 304 RKLPRGAE-----DREDKSNKGTLRPAKS---MDSLSAAAGASDEPEGLVGPSSPRPSPL 355
             +P G E      R + S+ G   P+ +       S   G+  +P+  V  + P P   
Sbjct: 534 TVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPG-- 591

Query: 356 LPESLENDSIEAAEGEQEPEAEA 378
                  ++ + A G+ +P+A A
Sbjct: 592 ------RNNSQIASGQNQPQAAA 608


>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
           sapiens]
          Length = 874

 Score =  103 bits (258), Expect = 7e-22
 Identities = 59/181 (32%), Positives = 103/181 (56%), Gaps = 8/181 (4%)

Query: 37  LKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQE-FESERKPDLRRDVYLQDIHCVSSLC 94
           ++ C + VE  G+ + G+YR+ GV+S +QKL    F  +  PD+  D+ L D   ++S  
Sbjct: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457

Query: 95  KAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVH 154
           K Y R L +PL+TY+L+  F  AV    +  R+  +  ++ +LP  N   L+ L++HLV 
Sbjct: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517

Query: 155 MASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQL 214
           ++  S Q  M   NL +++ P L+R+++         AA M ++ Q+IVVE ++ H +++
Sbjct: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE------ETVAAMMNIKFQNIVVEILIEHYEKI 571

Query: 215 F 215
           F
Sbjct: 572 F 572


>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
           sapiens]
          Length = 731

 Score =  103 bits (256), Expect = 1e-21
 Identities = 71/221 (32%), Positives = 109/221 (49%), Gaps = 21/221 (9%)

Query: 5   QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
           Q  +++G  +++VFGC L+   Q  G  VP  L+ C   V++ G+ VDGIYR+SG  + +
Sbjct: 508 QSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVV 567

Query: 64  QKLRQEFESER------------------KPDLRRDVYLQDIHCVSSLCKAYFRELPDPL 105
           QKLR   + ER                  + DL    +  DIH V+   K + RELP PL
Sbjct: 568 QKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW-DDIHVVTGALKLFLRELPQPL 626

Query: 106 LTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMH 165
           +   L   F  A+ +    + L +I E++  +P PN+ TL +L+ HL  + + S +  M 
Sbjct: 627 VPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMT 686

Query: 166 ARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEF 206
             NL IV+ P L R +  E S     A +    VQ ++  F
Sbjct: 687 PHNLGIVFGPTLFRPEQ-ETSDPAAHALYPGQLVQLMLTNF 726


>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
          Length = 818

 Score =  103 bits (256), Expect = 1e-21
 Identities = 127/499 (25%), Positives = 219/499 (43%), Gaps = 47/499 (9%)

Query: 6   KGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQ 64
           K +++   ++  FG  L+EHL  SG+E+   +++C   + E G+ + G++R++  +S ++
Sbjct: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300

Query: 65  KLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEP 124
           KL+   +     D++   Y  D H ++   K+Y RELP+PL+T+ LYD++ +A  VQ + 
Sbjct: 301 KLKAALDC-CVVDVQE--YSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQD 357

Query: 125 ERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIE 184
           ++L  +     +LP  N+  + +L++ L  ++ +     M   N+AIV  PNLL     +
Sbjct: 358 KKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP---Q 414

Query: 185 ASGFNGTAAFMEVRVQSI-VVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPED 243
           A G N T     V +Q + ++E I+ H D  F       GE+E        T   GSP  
Sbjct: 415 AEG-NITEMMTTVSLQIVGIIEPIIQHADWFF------PGEIEFNI-----TGNYGSPVH 462

Query: 244 LMPRPLPYHLPS--ILQAGDGPPQM--RPYHTIIE--IAEHKRKGSLKVRKWRSIFNLGR 297
           +        +PS  +  A    P+   RP     +  + E  +K  L     R I ++G 
Sbjct: 463 VNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGL-----RKIQSMGV 517

Query: 298 SGHETKRKLPRGAE-DREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPL- 355
              +T     RG+   R+      +++P      L+A   +    + L  P++P  SP  
Sbjct: 518 RVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSG 577

Query: 356 --LPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHIS 413
             L    E  S   ++ E  P +   G   S  GT  AG    + G    A+  A    S
Sbjct: 578 LGLQPGPERTSTTKSK-ELSPGSAQKGSPGSSQGTACAG---TQPGAQPGAQPGASPSPS 633

Query: 414 DPYNVNLPLHITSI----LSVPPNIISNV--SLARLTRGLECPALQHRPSPASGPGP-GP 466
            P     P  +  +      +PP +      ++A  + G   P +   P+P S P P G 
Sbjct: 634 QPPADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSP-VSLSPTPPSTPSPYGL 692

Query: 467 GLGPGPPDEKLEASPASSP 485
               G      + SPA++P
Sbjct: 693 SYPQGYSLASGQLSPAAAP 711


>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
           sapiens]
          Length = 547

 Score =  103 bits (256), Expect = 1e-21
 Identities = 71/221 (32%), Positives = 109/221 (49%), Gaps = 21/221 (9%)

Query: 5   QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
           Q  +++G  +++VFGC L+   Q  G  VP  L+ C   V++ G+ VDGIYR+SG  + +
Sbjct: 324 QSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVV 383

Query: 64  QKLRQEFESER------------------KPDLRRDVYLQDIHCVSSLCKAYFRELPDPL 105
           QKLR   + ER                  + DL    +  DIH V+   K + RELP PL
Sbjct: 384 QKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW-DDIHVVTGALKLFLRELPQPL 442

Query: 106 LTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMH 165
           +   L   F  A+ +    + L +I E++  +P PN+ TL +L+ HL  + + S +  M 
Sbjct: 443 VPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMT 502

Query: 166 ARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEF 206
             NL IV+ P L R +  E S     A +    VQ ++  F
Sbjct: 503 PHNLGIVFGPTLFRPEQ-ETSDPAAHALYPGQLVQLMLTNF 542


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score =  102 bits (253), Expect = 3e-21
 Identities = 125/479 (26%), Positives = 195/479 (40%), Gaps = 47/479 (9%)

Query: 458  PASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSS 517
            P    G     G G  ++++EA+  +  +   G  +    L D L+ + + S    +   
Sbjct: 587  PEEKEGAEDSKGNGIEEQEVEANEENVKV-HGGRKEKTEILSDDLTDKAEVSEGKAKSVG 645

Query: 518  SSEPEWVGAEDGEVAQAEAAGAAFSP-----GEDDPGMGYLEELLGVGP----QVEEFSV 568
             +E    G  DG   +  +    +       GE D G G +E   G G     + EE+  
Sbjct: 646  EAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP-GEGEKELAEKEEWKK 704

Query: 569  EPPLDDLSLDEAQFVLAPSCCSLDSAGPRP--EVEEENGEEVFLSAYDDLSPLLGPKPPI 626
                +    +  Q         ++  G     E EEE G+       +      G    +
Sbjct: 705  RDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEV 764

Query: 627  WKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAE-------PGGRLDIRE--EAEG 677
                   EGE     R    + GEE+     GE+++ E        GG ++  E  E +G
Sbjct: 765  EGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824

Query: 678  SPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS----KGQKKADSMEAKG 733
              E + E G+  E+ GE  G +E      EG  EE E K E+     +G+++ +  E +G
Sbjct: 825  EREEEEEEGEGEEEEGE--GEEEEG----EGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG 878

Query: 734  VEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQG-AQEDQVAEEKWEVVQKQEAE 792
             EE G  E  +E E E E EE E   E + E   + E+G  + ++  EE     +++E E
Sbjct: 879  EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE 938

Query: 793  GVRED-EDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEA------ 845
            G  ED E +G+ E+G  E  +++G+GE     E   E G GE   E E G+GE       
Sbjct: 939  GEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGE--GEEEEGEGEGEEEEGE 996

Query: 846  -EGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQ 903
             EG++   G   EE+   EG      EV+   EG     E EE   +  + EE E EG+
Sbjct: 997  EEGEEEGEG---EEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE-EEGEEREKEGE 1051



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 87/301 (28%), Positives = 138/301 (45%), Gaps = 27/301 (8%)

Query: 628 KGSGSLEGEAAGCGRQALGQGGE-EQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAG 686
           K  G  E E  G G + L +  E ++   E  E K+ E G + +  +E E   E   E G
Sbjct: 679 KDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEE--EHG 736

Query: 687 KASEDRGEAGGSQETKVRLRE-GSREETEAKEEKSKGQKKADSMEAKGVEEPGGDE--YT 743
           +  E+ G+    +E +   +E G  EE E + EK +G++K +  E  G EE G +E    
Sbjct: 737 EGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKE--ERAGKEEKGEEEGDQG 794

Query: 744 DEKEKEIEREEDEQREEAQVEAGR----------DLEQGAQEDQVAEEKWEVVQKQEAEG 793
           + +E+E E   +E+ E  +VE G           + E+G  E++  E + E  + +E EG
Sbjct: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEG 854

Query: 794 VREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGD----- 848
             + E++G+  +G  E  + +G+GE+        E G GE  +E   G+GE EG+     
Sbjct: 855 EGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914

Query: 849 QRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQ-PPQPEEMEPEGQPSPD 907
           +   G   EE    EG G    E +   EG     E EE   +   + EE E EG+   +
Sbjct: 915 EEGEGKGEEEGEEGEGEGE---EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGE 971

Query: 908 G 908
           G
Sbjct: 972 G 972



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 87/291 (29%), Positives = 130/291 (44%), Gaps = 31/291 (10%)

Query: 628  KGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGK 687
            +G    EG     G    G+G  E+   E GE ++ E  G     EE EG  E +   GK
Sbjct: 804  RGEEKEEGGEVEGGEVEEGKGEREEE-EEEGEGEEEEGEG-----EEEEGEGEEEEGEGK 857

Query: 688  ASEDRGEAGGSQETKVRLREGSREETEAK-EEKSKGQKKADSMEAKGVEEPGGDEYTDEK 746
              E+  E  G +E +    EG  EE E + EE+ +G+ + +  E +G EE  G+   +E 
Sbjct: 858  GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917

Query: 747  EKEIEREEDEQREEAQVEAGR-DLEQGAQEDQVAEEKWEVVQKQ-EAEGVREDEDKGQRE 804
            E + E E +E   E + E G  + E G  E +  E +WE  +++ E EG  E E +G+  
Sbjct: 918  EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977

Query: 805  KGYHEARKDQGDGEDSRSPEAATEGGAGEVS-----KERESG--DGEAEGDQRAGGYYLE 857
            +G  E  + +G+GE+    E   E G GE       +E E G  +GE EG++        
Sbjct: 978  EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEE-------- 1029

Query: 858  EDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDG 908
                 EG G    E +  +EG     E E    +  + EE E EG+    G
Sbjct: 1030 ----GEGEGE---EEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETG 1073



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 89/308 (28%), Positives = 136/308 (44%), Gaps = 23/308 (7%)

Query: 616 LSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACW--EVGEDKQAEPGGRLDIRE 673
           LS  L  K  + +G     GEA   G +  G G  E+     E  +D++ E G +   R 
Sbjct: 626 LSDDLTDKAEVSEGKAKSVGEAED-GPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRG 684

Query: 674 EAEGSPETKVEAGKASEDRGEAGGSQETKVR-----------LREGSREETEAKEEKSKG 722
           E E   E + E  +  E +   G  QE K R           + EG  EE    EE+   
Sbjct: 685 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGD 744

Query: 723 QKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEK 782
           +++ +  E +G EE  G+E   E+EKE    + E+R   + +   + +QG  E++  E +
Sbjct: 745 REEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGR 804

Query: 783 WEVVQK-QEAEGVREDEDKGQREKGYHEARKDQGDGE-DSRSPEAATEGGAGEVSKERES 840
            E  ++  E EG   +E KG+RE+   E   ++ +GE +    E   E G G+  +E E 
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864

Query: 841 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP 900
           G+GE EG++  G    EE    EG G    E +   EG     E E       + EE E 
Sbjct: 865 GEGEEEGEEGEGEGEEEE---GEGEG----EEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917

Query: 901 EGQPSPDG 908
           EG+   +G
Sbjct: 918 EGKGEEEG 925



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 105/343 (30%), Positives = 153/343 (44%), Gaps = 36/343 (10%)

Query: 527  EDGEVAQAEAAGAAFSPGED-DPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLA 585
            E+GE  + E AG      E+ D G G  EE  G G + EE        ++   E +    
Sbjct: 771  EEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG------EVEGGEVE---- 820

Query: 586  PSCCSLDSAGPRPEVEEEN-GEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQA 644
                  +  G R E EEE  GEE      ++       +    +G G  EGE  G G + 
Sbjct: 821  ------EGKGEREEEEEEGEGEEEEGEGEEEEGE---GEEEEGEGKGEEEGEE-GEGEEE 870

Query: 645  LGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVR 704
             G+ GE +   E GE +  E G      EE EG  E + E G+  E+ GE  G +E +  
Sbjct: 871  -GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE-GEGEEEEGEGKGEEEGEEG 928

Query: 705  LREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVE 764
              EG  EE E + E  +G+ + +  E +G EE G  E  +E E E E  E E  EE    
Sbjct: 929  EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEG 988

Query: 765  AGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPE 824
             G + E+G +E    EE+ E   ++E EG  E+E++G+ E G  E  + +G+GE+    E
Sbjct: 989  EGEE-EEGEEE---GEEEGE--GEEEGEGEGEEEEEGEVE-GEVEGEEGEGEGEEEEGEE 1041

Query: 825  AATE---GGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEG 864
               E    G GE ++     + E EG  +  G   EE+   +G
Sbjct: 1042 EGEEREKEGEGEENRRNREEEEEEEGKYQETGE--EENERQDG 1082



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 81/286 (28%), Positives = 127/286 (44%), Gaps = 25/286 (8%)

Query: 641  GRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQE 700
            G +  G+G EE+   E  E+K+ E G      EE EG  E +    K  E  G+    +E
Sbjct: 731  GEEEHGEGEEEEGDREEEEEKEGE-GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE 789

Query: 701  TKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREE 760
                  EG + E E +E + +G++K +  E +G E   G    +E+E+E E EE+E   E
Sbjct: 790  ------EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843

Query: 761  AQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDED-KGQ-REKGYHEARKDQGDGE 818
             +   G + E   + ++  EE     + +E EG  E+E+ +G+  E+G  E  +++G+GE
Sbjct: 844  EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE 903

Query: 819  DSRSPEAATEGGAGEVSKERESGDGEAEGDQRAG---------------GYYLEEDTLSE 863
                 E   E   GE   E E  +GE EG++  G               G +  E+   E
Sbjct: 904  GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE 963

Query: 864  GSGVASLEVDCAK-EGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDG 908
            G G    E +  + EG     E E    +    EE E EG+   +G
Sbjct: 964  GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEG 1009



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 75/259 (28%), Positives = 121/259 (46%), Gaps = 32/259 (12%)

Query: 669 LDIREEAEGSPETK--------VEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS 720
           ++I EE EG+ ++K        VEA +  E+    GG +E    L +   ++ E  E K+
Sbjct: 584 VEIPEEKEGAEDSKGNGIEEQEVEANE--ENVKVHGGRKEKTEILSDDLTDKAEVSEGKA 641

Query: 721 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGR-DLEQ-GAQEDQV 778
           K        EA+   E  GD   +E     E  +DE+RE+ + + GR ++E+ G  E ++
Sbjct: 642 KSVG-----EAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKEL 696

Query: 779 AE-EKW------EVVQKQEAEGVRED-----EDKGQREKGYHEARKDQGDGEDSRSPEAA 826
           AE E+W      E  QK+  +G +++     E+ G+ E G  E  +   + E+ +  E  
Sbjct: 697 AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGK 756

Query: 827 TEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEME 886
            EG   EV  ERE  +GE + ++RAG     E+   +G G    E +   E      E+E
Sbjct: 757 EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE-ETEGRGEEKEEGGEVE 815

Query: 887 --EVAPQPPQPEEMEPEGQ 903
             EV     + EE E EG+
Sbjct: 816 GGEVEEGKGEREEEEEEGE 834



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 55/195 (28%), Positives = 93/195 (47%), Gaps = 18/195 (9%)

Query: 628  KGSGSLEGEAAGCGRQALGQGGEEQACWE-VGEDKQAEPGGRLDIREEAEGSPETKVEAG 686
            +G G  EGE  G   +  G+G EE    E  GE+++ E  G     E+ EG  E +    
Sbjct: 901  EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG-----EDGEGEGEEEEGEW 955

Query: 687  KASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEY---- 742
            +  E+ GE  G +E +    EG   E E +EE+ +G+ + +  E +G EE  G+E     
Sbjct: 956  EGEEEEGEGEGEEEGE---GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE 1012

Query: 743  -TDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKG 801
              +E+E E+E E + +  E + E     E+G +E +  E++ E  + +      E+E+  
Sbjct: 1013 GEEEEEGEVEGEVEGEEGEGEGEE----EEGEEEGEEREKEGEGEENRRNREEEEEEEGK 1068

Query: 802  QREKGYHEARKDQGD 816
             +E G  E  +  G+
Sbjct: 1069 YQETGEEENERQDGE 1083



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 86/312 (27%), Positives = 127/312 (40%), Gaps = 91/312 (29%)

Query: 514  EDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLD 573
            E+    E E  G  +GE  + E  G     GE+  G G  EE  G G   E    E    
Sbjct: 897  EEEGEGEGEEEGEGEGEEEEGEGKGE--EEGEEGEGEGEEEEGEGEGEDGEGEGEE---- 950

Query: 574  DLSLDEAQFVLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSL 633
                +E ++                E EEE GE                      G G  
Sbjct: 951  ----EEGEW----------------EGEEEEGE----------------------GEGEE 968

Query: 634  EGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRG 693
            EGE  G G +  G+G EE+   E GE+++ E  G     EE EG            E+ G
Sbjct: 969  EGE--GEGEEGEGEGEEEEGEGE-GEEEEGEEEG----EEEGEG------------EEEG 1009

Query: 694  EAGGSQETKVRLREGSRE-ETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIER 752
            E  G +E      EG  E E E +E + +G+            E  G+E  +E+EKE E 
Sbjct: 1010 EGEGEEE-----EEGEVEGEVEGEEGEGEGE------------EEEGEEEGEEREKEGEG 1052

Query: 753  EEDEQ-REEAQVEAGRDLEQGAQEDQVAE-EKWEVVQKQEAEGVREDEDKGQREKGYHEA 810
            EE+ + REE + E G+  E G +E++  + E+++ V K +   V+  + K  ++K     
Sbjct: 1053 EENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKG-SVKYGKHKTYQKK---SV 1108

Query: 811  RKDQGDGEDSRS 822
               QG+G++ RS
Sbjct: 1109 TNTQGNGKEQRS 1120


>gi|91208437 GEM interacting protein [Homo sapiens]
          Length = 970

 Score =  102 bits (253), Expect = 3e-21
 Identities = 84/288 (29%), Positives = 133/288 (46%), Gaps = 30/288 (10%)

Query: 7   GKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQK 65
           G ++  A+  +FG D  +  +   +EVP V+  C   +E   + V GIYR+SG    +++
Sbjct: 538 GHRRLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVER 597

Query: 66  LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV----- 120
           L Q FE+ R      ++     H VSS+ K + +EL +P++ + LYD F           
Sbjct: 598 LCQAFENGRA---LVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADP 654

Query: 121 -------QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVW 173
                     PE +  +  +L +LP  NY TL  L+ HL  +A+   +  M A NL IV+
Sbjct: 655 GDDPGTPSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVF 714

Query: 174 APNLLRSKD-IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSL 232
            P LLR  D   A+        ++   Q+ +VEF++ H +Q+FG   L          S 
Sbjct: 715 GPTLLRPPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSS 774

Query: 233 PGTRASGSPEDLMPRPLPYHL-----PSILQAGDGP-PQMRPYHTIIE 274
           P    +  P     +P P HL     P +L +  GP PQ   +H+ +E
Sbjct: 775 P----APGPLTTSSQPPPPHLDPDSQPPVLASDPGPDPQ---HHSTLE 815


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score =  101 bits (252), Expect = 3e-21
 Identities = 65/203 (32%), Positives = 102/203 (50%), Gaps = 4/203 (1%)

Query: 16  RVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFESER 74
           RV+G  L  HLQ  G+E+   +++C   +   G+ + G++RL+  +S +++L+Q   S+ 
Sbjct: 272 RVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDP 331

Query: 75  KPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVL 134
                 + +  D H V+   K+Y RELP+PL+T+ LYD +  A  ++    RL  + EV 
Sbjct: 332 HS---LEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVC 388

Query: 135 RELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAF 194
             LP  N   L +LM+ L  +A       M   N+AIV  PNLL   + E       AA 
Sbjct: 389 SRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAAS 448

Query: 195 MEVRVQSIVVEFILTHVDQLFGG 217
           +       VVE ++   D LF G
Sbjct: 449 VSSIQVVGVVEALIQSADTLFPG 471



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 37/153 (24%), Positives = 53/153 (34%), Gaps = 14/153 (9%)

Query: 450 PALQHRPSPASGPGPGPGLGPGPPDEKLEAS----PASSPLADSGPDDLAPALEDSLSQE 505
           PA    P+PA  P P P L      E+ E+     PAS  +  S P+  AP         
Sbjct: 507 PATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAP--------- 557

Query: 506 VQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEE 565
           V+D     +  + + P  +       +++        PG   PG         VG  +  
Sbjct: 558 VEDMARRTKRPAPARPT-MPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRA 616

Query: 566 FSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRP 598
            +V PPL       A+     S  S   A P P
Sbjct: 617 PTVPPPLPPTPPQPARRQSRRSPASPSPASPGP 649


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score =  101 bits (251), Expect = 4e-21
 Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 3/180 (1%)

Query: 8    KKKGSAKER-VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
            K+  S K+  VFG  +    +    +VP +++ C E +E  G+ + GIYR+SGV+++IQ 
Sbjct: 997  KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1056

Query: 66   LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
            L+  F+   K D+   +   D++ ++   K YFRELP+PL T   Y  FAE + +     
Sbjct: 1057 LKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVA 1115

Query: 126  RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
            +   +L +L  LP  N  T  FL+ HL  +A   A   M   NLA V+ P LLR  + E+
Sbjct: 1116 KESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1175


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score =  101 bits (251), Expect = 4e-21
 Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 3/180 (1%)

Query: 8    KKKGSAKER-VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
            K+  S K+  VFG  +    +    +VP +++ C E +E  G+ + GIYR+SGV+++IQ 
Sbjct: 1041 KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1100

Query: 66   LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
            L+  F+   K D+   +   D++ ++   K YFRELP+PL T   Y  FAE + +     
Sbjct: 1101 LKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVA 1159

Query: 126  RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
            +   +L +L  LP  N  T  FL+ HL  +A   A   M   NLA V+ P LLR  + E+
Sbjct: 1160 KESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1219


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.131    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,880,415
Number of Sequences: 37866
Number of extensions: 3325972
Number of successful extensions: 33022
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 479
Number of HSP's successfully gapped in prelim test: 1176
Number of HSP's that attempted gapping in prelim test: 17654
Number of HSP's gapped (non-prelim): 8989
length of query: 1101
length of database: 18,247,518
effective HSP length: 113
effective length of query: 988
effective length of database: 13,968,660
effective search space: 13801036080
effective search space used: 13801036080
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.