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Search of human proteins with 71040096
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
(890 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 1801 0.0
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 1365 0.0
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens] 358 1e-98
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens] 346 5e-95
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens] 346 5e-95
gi|23510413 sorting nexin 26 [Homo sapiens] 315 9e-86
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 125 1e-28
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 123 7e-28
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 123 7e-28
gi|188497642 ARHGAP15 [Homo sapiens] 121 3e-27
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 119 1e-26
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 119 1e-26
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 119 1e-26
gi|229094128 active breakpoint cluster region-related protein i... 116 8e-26
gi|38679957 active breakpoint cluster region-related protein is... 116 8e-26
gi|38679954 active breakpoint cluster region-related protein is... 116 8e-26
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 112 2e-24
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 112 2e-24
gi|54860105 nadrin isoform 2 [Homo sapiens] 107 5e-23
gi|5803145 ralA binding protein 1 [Homo sapiens] 107 6e-23
gi|54860079 nadrin isoform 1 [Homo sapiens] 107 6e-23
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 103 5e-22
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 103 9e-22
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 103 9e-22
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 103 9e-22
gi|91208437 GEM interacting protein [Homo sapiens] 102 2e-21
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 101 3e-21
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 101 4e-21
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 101 4e-21
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 100 8e-21
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 1801 bits (4666), Expect = 0.0
Identities = 890/890 (100%), Positives = 890/890 (100%)
Query: 1 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60
MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
Sbjct: 1 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60
Query: 61 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
Sbjct: 61 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
Query: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
Sbjct: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
Query: 181 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240
KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
Sbjct: 181 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240
Query: 241 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300
PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
Sbjct: 241 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300
Query: 301 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360
ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
Sbjct: 301 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360
Query: 361 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420
ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
Sbjct: 361 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420
Query: 421 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480
PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
Sbjct: 421 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480
Query: 481 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540
PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
Sbjct: 481 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540
Query: 541 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600
FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
Sbjct: 541 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600
Query: 601 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660
EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
Sbjct: 601 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660
Query: 661 KQAEPGGRLDIREEAEGTPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQV 720
KQAEPGGRLDIREEAEGTPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQV
Sbjct: 661 KQAEPGGRLDIREEAEGTPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQV 720
Query: 721 QQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRN 780
QQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRN
Sbjct: 721 QQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRN 780
Query: 781 GGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLE 840
GGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLE
Sbjct: 781 GGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLE 840
Query: 841 LPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL 890
LPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL
Sbjct: 841 LPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL 890
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 1365 bits (3534), Expect = 0.0
Identities = 678/680 (99%), Positives = 680/680 (100%)
Query: 1 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60
MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
Sbjct: 1 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS 60
Query: 61 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
Sbjct: 61 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV 120
Query: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
Sbjct: 121 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS 180
Query: 181 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240
KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
Sbjct: 181 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS 240
Query: 241 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300
PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
Sbjct: 241 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH 300
Query: 301 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360
ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
Sbjct: 301 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL 360
Query: 361 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420
ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
Sbjct: 361 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL 420
Query: 421 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480
PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
Sbjct: 421 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS 480
Query: 481 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540
PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
Sbjct: 481 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA 540
Query: 541 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600
FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
Sbjct: 541 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV 600
Query: 601 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660
EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
Sbjct: 601 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED 660
Query: 661 KQAEPGGRLDIREEAEGTPQ 680
KQAEPGGRLDIREEAEG+P+
Sbjct: 661 KQAEPGGRLDIREEAEGSPE 680
Score = 446 bits (1146), Expect = e-125
Identities = 226/266 (84%), Positives = 229/266 (86%), Gaps = 9/266 (3%)
Query: 629 GSGSLEGEAAGCG----RQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGTPQPPQP 684
G G EG+ G L +G A EV K+ P E E PQPPQP
Sbjct: 841 GDGEAEGDQRAGGYYLEEDTLSEGSGV-ASLEVDCAKEGNPHSS----EMEEVAPQPPQP 895
Query: 685 EEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCS 744
EEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCS
Sbjct: 896 EEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCS 955
Query: 745 KIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGV 804
KIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGV
Sbjct: 956 KIHVAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGV 1015
Query: 805 RRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQV 864
RRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQV
Sbjct: 1016 RRTQTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQV 1075
Query: 865 PDPLLSSQRRSYAFETQANPGKGEGL 890
PDPLLSSQRRSYAFETQANPGKGEGL
Sbjct: 1076 PDPLLSSQRRSYAFETQANPGKGEGL 1101
>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
Length = 1444
Score = 358 bits (919), Expect = 1e-98
Identities = 195/359 (54%), Positives = 249/359 (69%), Gaps = 20/359 (5%)
Query: 3 SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62
++QK K+KG+A FGCDL E+L+ SGQ+VP VLKSCAEF+E +G+VDGIYRLSGV+SN
Sbjct: 6 AKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSN 63
Query: 63 IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122
IQ+LRQEF S++ PDL R+VYLQDIHCV SLCK YFRELP+PLLTY LY+KF EAV
Sbjct: 64 IQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCP 123
Query: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
E +L +I V++ELP +YRTLE+L+RHL H+ASFS++TNMHARNLA+VWAPNLLRSK+
Sbjct: 124 EEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKE 183
Query: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAA---LSGGEVESGWRSLPGTRAS- 238
IEA+G NG AAF+ VRVQ +V+EFIL HVDQ+F A L E +SL S
Sbjct: 184 IEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSL 243
Query: 239 ----GSPEDLMPRPLPYHLPSILQAGDG------PPQMRPYHTIIEIAEHKRKGSLKVRK 288
S E+ R L + P+ + + PP +HT++E+ ++KRK S K +K
Sbjct: 244 PMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKK 303
Query: 289 WRSIFNLGRSGHETKRKLPRG----AEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEG 343
W+SIFNLGRSG ++K KL R + K T+RPAKSMDSL + E +G
Sbjct: 304 WKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKETKG 362
Score = 32.3 bits (72), Expect = 2.0
Identities = 13/31 (41%), Positives = 23/31 (74%)
Query: 715 STLVQVQQVRSVPVVPPKPQFAKMPSAMCSK 745
S +V++ Q R+VPV+PPK Q+ ++P + S+
Sbjct: 1189 SFMVKMCQARAVPVIPPKIQYTQIPQPLPSQ 1219
>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
Length = 2087
Score = 346 bits (888), Expect = 5e-95
Identities = 200/383 (52%), Positives = 256/383 (66%), Gaps = 31/383 (8%)
Query: 1 MKSR---QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLS 57
MKSR QK K++G KERVFGCDL EHL +SG EVPQVL+SC F+E YG+VDGIYRLS
Sbjct: 350 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 409
Query: 58 GVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEA 117
GV+SNIQ+LR EF+SE PDL ++ Y+QDIH V SLCK YFRELP+PLLTY+LY+KF++A
Sbjct: 410 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 469
Query: 118 VGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNL 177
V + ERL+KI +V+++LP P+YRTLEFLMRHL +A + + TNMHA+NLAIVWAPNL
Sbjct: 470 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 529
Query: 178 LRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGG--------AALSGGEVESGW 229
LRSK IE++ F+GTAAFMEVR+QS+VVEFIL HVD LF G A S +S
Sbjct: 530 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 589
Query: 230 RSLPGTRASGSPEDLMPRPLPYHLPSI-----LQAGDGPPQMR-PYHTIIEIAEHKRKGS 283
S P T+ E + P + ++ G+GP ++ +HTIIE +++
Sbjct: 590 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 649
Query: 284 LKVRK-----WRSIFNLGRSGHETKRKLPRG-AEDREDKS-------NKGTLRPAKSMDS 330
K++K WRS FNLG+S +KRKL R +E E K+ +GTLR AKS +S
Sbjct: 650 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 709
Query: 331 LSAAAGASDEPEGLVGPSSPRPS 353
L+ + A D L P PR S
Sbjct: 710 LT-SLHAVDGDSKLFRPRRPRSS 731
Score = 32.3 bits (72), Expect = 2.0
Identities = 28/113 (24%), Positives = 40/113 (35%), Gaps = 9/113 (7%)
Query: 644 ALGQGGEEQACWEVGEDKQAEPGGRLDI-REEAEGTPQPPQPEEMEPEGQPSPDGCLCPC 702
A Q ++A W+V E + R P PP P + E P
Sbjct: 1269 ATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVVGQVQAAT 1328
Query: 703 SLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCP 755
++GL +VQ V VP PP+P+ P++ A A CP
Sbjct: 1329 NIGLNNSH--------KVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCP 1373
>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
Length = 1738
Score = 346 bits (888), Expect = 5e-95
Identities = 200/383 (52%), Positives = 256/383 (66%), Gaps = 31/383 (8%)
Query: 1 MKSR---QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLS 57
MKSR QK K++G KERVFGCDL EHL +SG EVPQVL+SC F+E YG+VDGIYRLS
Sbjct: 1 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 60
Query: 58 GVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEA 117
GV+SNIQ+LR EF+SE PDL ++ Y+QDIH V SLCK YFRELP+PLLTY+LY+KF++A
Sbjct: 61 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 120
Query: 118 VGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNL 177
V + ERL+KI +V+++LP P+YRTLEFLMRHL +A + + TNMHA+NLAIVWAPNL
Sbjct: 121 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 180
Query: 178 LRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGG--------AALSGGEVESGW 229
LRSK IE++ F+GTAAFMEVR+QS+VVEFIL HVD LF G A S +S
Sbjct: 181 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 240
Query: 230 RSLPGTRASGSPEDLMPRPLPYHLPSI-----LQAGDGPPQMR-PYHTIIEIAEHKRKGS 283
S P T+ E + P + ++ G+GP ++ +HTIIE +++
Sbjct: 241 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 300
Query: 284 LKVRK-----WRSIFNLGRSGHETKRKLPRG-AEDREDKS-------NKGTLRPAKSMDS 330
K++K WRS FNLG+S +KRKL R +E E K+ +GTLR AKS +S
Sbjct: 301 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 360
Query: 331 LSAAAGASDEPEGLVGPSSPRPS 353
L+ + A D L P PR S
Sbjct: 361 LT-SLHAVDGDSKLFRPRRPRSS 382
Score = 32.3 bits (72), Expect = 2.0
Identities = 28/113 (24%), Positives = 40/113 (35%), Gaps = 9/113 (7%)
Query: 644 ALGQGGEEQACWEVGEDKQAEPGGRLDI-REEAEGTPQPPQPEEMEPEGQPSPDGCLCPC 702
A Q ++A W+V E + R P PP P + E P
Sbjct: 920 ATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVVGQVQAAT 979
Query: 703 SLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCP 755
++GL +VQ V VP PP+P+ P++ A A CP
Sbjct: 980 NIGLNNSH--------KVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCP 1024
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 315 bits (808), Expect = 9e-86
Identities = 186/369 (50%), Positives = 237/369 (64%), Gaps = 16/369 (4%)
Query: 3 SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62
SRQ+ +++G ++RVFGCDL EHL +SGQ+VPQVL+ C+EF+E +GVVDGIYRLSGVSSN
Sbjct: 298 SRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSN 357
Query: 63 IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122
IQ+LR EF+SER P+L +LQDIH VSSLCK YFRELP+PLLTY+LY KF+EA+ V
Sbjct: 358 IQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPG 417
Query: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
E ERLV++ +V+++LP P+YRTLE+L+RHL MA SA T+MHARNLAIVWAPNLLRS +
Sbjct: 418 EEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSME 477
Query: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRA-SGSP 241
+E+ G G AAF EVRVQS+VVEF+LTHVD LF S G +G LP ++ +GS
Sbjct: 478 LESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSC 537
Query: 242 EDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSL--KVRK-----WRSIFN 294
L + Q G P +RKG K RK W++ F
Sbjct: 538 PSTRLLTLE-EAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFA 596
Query: 295 LGRSGHETKRK-LPRGAEDREDKSNKG------TLRPAKSMDSLSAAAGASDEPEGLVGP 347
LGR ++K LP R G TLR AKS +SLS+ A ++ P
Sbjct: 597 LGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAP 656
Query: 348 SSPRPSPLL 356
+S P+P L
Sbjct: 657 ASATPTPAL 665
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 125 bits (315), Expect = 1e-28
Identities = 78/214 (36%), Positives = 122/214 (57%), Gaps = 11/214 (5%)
Query: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Q ++KG K++VFG +L Q VP+ +K C E VEE+G+ +DGIYR+SG + I
Sbjct: 641 QAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVI 700
Query: 64 QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
QKLR + K DL D +DIH ++ K +FRELP+PL T+ ++ F A+ + E
Sbjct: 701 QKLRFAVNHDEKLDLN-DSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAI--KQE 757
Query: 124 P-ERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
P +R+ + +++R+LP PN T++ L RHL + + M +++AIV+ P LL+ +
Sbjct: 758 PRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEK 817
Query: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216
G A V Q+ +VE IL + +FG
Sbjct: 818 -----ETGNIAVHTV-YQNQIVELILLELSSIFG 845
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 123 bits (309), Expect = 7e-28
Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)
Query: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Q ++KG K++VFGC L + VP+ ++ C VE G+ +DG+YR+SG + I
Sbjct: 314 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 373
Query: 64 QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
QKLR + + + + DL D +D+H ++ K +FRELP+PL + + +F A+ +Q +
Sbjct: 374 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 432
Query: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
R + +++R LP PN+ TL L +HL + Q M +++AIV+ P LLR ++
Sbjct: 433 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 491
Query: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
E + T F Q+ VVE IL +F
Sbjct: 492 EETSMPMTMVF-----QNQVVELILQQCADIF 518
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 123 bits (309), Expect = 7e-28
Identities = 72/212 (33%), Positives = 117/212 (55%), Gaps = 8/212 (3%)
Query: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Q ++KG K++VFGC L + VP+ ++ C VE G+ +DG+YR+SG + I
Sbjct: 341 QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI 400
Query: 64 QKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE 123
QKLR + + + + DL D +D+H ++ K +FRELP+PL + + +F A+ +Q +
Sbjct: 401 QKLRYKVDHDERLDLD-DGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQ 459
Query: 124 PERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDI 183
R + +++R LP PN+ TL L +HL + Q M +++AIV+ P LLR ++
Sbjct: 460 ARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEV 518
Query: 184 EASGFNGTAAFMEVRVQSIVVEFILTHVDQLF 215
E + T F Q+ VVE IL +F
Sbjct: 519 EETSMPMTMVF-----QNQVVELILQQCADIF 545
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 121 bits (304), Expect = 3e-27
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 8/210 (3%)
Query: 8 KKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKL 66
++KG K+++FG L + + VP +K C E VE+ G+ VDGIYR+SG + IQKL
Sbjct: 269 QEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKL 328
Query: 67 RQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPER 126
R E K +L D +DIH V+ K +FRELP+PL Y +++F EA+ Q R
Sbjct: 329 RFIVNQEEKLNLD-DSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTR 387
Query: 127 LVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEAS 186
+ + ++++LP PN T++ L HL + + +++ M ++L IV+ P LLR A
Sbjct: 388 IEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR-----AE 442
Query: 187 GFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216
G A V Q+ + E +L+ ++FG
Sbjct: 443 NETGNMAIHMV-YQNQIAELMLSEYSKIFG 471
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 119 bits (298), Expect = 1e-26
Identities = 119/413 (28%), Positives = 187/413 (45%), Gaps = 44/413 (10%)
Query: 8 KKKGSAKERVFGCDLQE-HLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
KK A R FG L+E Q VP ++ +C VE G+ GIYR+ G ++ +
Sbjct: 799 KKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSS 858
Query: 66 LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
L+++ +D QD++ +SSL K++FR+LP+PL T Y+ F EA ++ E
Sbjct: 859 LQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARE 918
Query: 126 RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
R+ + +++R+LP Y TL+FL+ HL +A S + M RNLA+V+ P L+R+
Sbjct: 919 RMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRT----- 973
Query: 186 SGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLM 245
S N T + + +VE ++ H D F E + G R+ G D
Sbjct: 974 SEDNMTDMVTHMPDRYKIVETLIQHSDWFF------SDEEDKGERTPVG--------DKE 1019
Query: 246 PRPLP---YHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRK---WRSIFNLG-RS 298
P+ +P Y LP+I G P P + K KGS +K R + + S
Sbjct: 1020 PQAVPNIEYLLPNI---GRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFIS 1076
Query: 299 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE 358
KRK R A ++ + + A + + A G + P+G P P + PE
Sbjct: 1077 AVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQG------PLPGAVAPE 1130
Query: 359 SLENDSIEAAEGEQEPEAEA---LGGTNSEPGTPR---AGRSAIRAGGSSRAE 405
+ S AA E+ P A+ + G ++ R +G S RAG A+
Sbjct: 1131 APGRLSPPAAP-EERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEAD 1182
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 119 bits (298), Expect = 1e-26
Identities = 69/203 (33%), Positives = 116/203 (57%), Gaps = 8/203 (3%)
Query: 15 ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFESE 73
++V+ CDL ++ + P V+ C +E G+ +G+YR+SG S I+ ++ F+ +
Sbjct: 263 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 322
Query: 74 -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
K D+ ++Y +DI+ ++ K YFR+LP PL+TY Y KF E+ + E+L + E
Sbjct: 323 GEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHE 381
Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
L+ LP + TL +LM HL + + M+A NL IV+ P L+RS +++A A
Sbjct: 382 ALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDA-----MA 436
Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
A ++R Q +VVE ++ + D LF
Sbjct: 437 ALNDIRYQRLVVELLIKNEDILF 459
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 119 bits (298), Expect = 1e-26
Identities = 69/203 (33%), Positives = 116/203 (57%), Gaps = 8/203 (3%)
Query: 15 ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFESE 73
++V+ CDL ++ + P V+ C +E G+ +G+YR+SG S I+ ++ F+ +
Sbjct: 237 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 296
Query: 74 -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
K D+ ++Y +DI+ ++ K YFR+LP PL+TY Y KF E+ + E+L + E
Sbjct: 297 GEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHE 355
Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
L+ LP + TL +LM HL + + M+A NL IV+ P L+RS +++A A
Sbjct: 356 ALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDA-----MA 410
Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
A ++R Q +VVE ++ + D LF
Sbjct: 411 ALNDIRYQRLVVELLIKNEDILF 433
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 116 bits (291), Expect = 8e-26
Identities = 74/214 (34%), Positives = 117/214 (54%), Gaps = 7/214 (3%)
Query: 3 SRQKGKKKGSAKER--VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGV 59
SR K+ +K++ VFG + + +VP +++ C E VE+ G+ + GIYR+SGV
Sbjct: 582 SRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGV 641
Query: 60 SSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVG 119
+++IQ L+ F++ K D+ + DI+ ++ K YFRELP+PLLT RLY F E +
Sbjct: 642 ATDIQALKAVFDANNK-DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA 700
Query: 120 VQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLR 179
+ + ++ +LR LP PN T FL+ HL +A M NLA V+ P LLR
Sbjct: 701 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR 760
Query: 180 SKDIEASGFNGTAAFM---EVRVQSIVVEFILTH 210
++E+ +AA + +V Q V+ + L H
Sbjct: 761 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 794
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 116 bits (291), Expect = 8e-26
Identities = 74/214 (34%), Positives = 117/214 (54%), Gaps = 7/214 (3%)
Query: 3 SRQKGKKKGSAKER--VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGV 59
SR K+ +K++ VFG + + +VP +++ C E VE+ G+ + GIYR+SGV
Sbjct: 628 SRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGV 687
Query: 60 SSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVG 119
+++IQ L+ F++ K D+ + DI+ ++ K YFRELP+PLLT RLY F E +
Sbjct: 688 ATDIQALKAVFDANNK-DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA 746
Query: 120 VQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLR 179
+ + ++ +LR LP PN T FL+ HL +A M NLA V+ P LLR
Sbjct: 747 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR 806
Query: 180 SKDIEASGFNGTAAFM---EVRVQSIVVEFILTH 210
++E+ +AA + +V Q V+ + L H
Sbjct: 807 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 840
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 116 bits (291), Expect = 8e-26
Identities = 74/214 (34%), Positives = 117/214 (54%), Gaps = 7/214 (3%)
Query: 3 SRQKGKKKGSAKER--VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGV 59
SR K+ +K++ VFG + + +VP +++ C E VE+ G+ + GIYR+SGV
Sbjct: 591 SRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGV 650
Query: 60 SSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVG 119
+++IQ L+ F++ K D+ + DI+ ++ K YFRELP+PLLT RLY F E +
Sbjct: 651 ATDIQALKAVFDANNK-DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA 709
Query: 120 VQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLR 179
+ + ++ +LR LP PN T FL+ HL +A M NLA V+ P LLR
Sbjct: 710 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR 769
Query: 180 SKDIEASGFNGTAAFM---EVRVQSIVVEFILTH 210
++E+ +AA + +V Q V+ + L H
Sbjct: 770 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 803
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 112 bits (279), Expect = 2e-24
Identities = 65/203 (32%), Positives = 110/203 (54%), Gaps = 8/203 (3%)
Query: 15 ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVV-DGIYRLSGVSSNIQKLRQEFESE 73
++V+ CDL ++ + P V+ C +E G+ +G+YR+SG + +I+ ++ F+ +
Sbjct: 272 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 331
Query: 74 -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
K D+ +VY DI+ ++ K YFR+LP P++TY Y KF +A + ERL + E
Sbjct: 332 GEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE 390
Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
VL LP +Y TL +LM HL + M+A NL IV+ P L+R +
Sbjct: 391 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDST-----LT 445
Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
++R Q ++V+ ++ + D LF
Sbjct: 446 TLHDMRYQKLIVQILIENEDVLF 468
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 112 bits (279), Expect = 2e-24
Identities = 65/203 (32%), Positives = 110/203 (54%), Gaps = 8/203 (3%)
Query: 15 ERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVV-DGIYRLSGVSSNIQKLRQEFESE 73
++V+ CDL ++ + P V+ C +E G+ +G+YR+SG + +I+ ++ F+ +
Sbjct: 136 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 195
Query: 74 -RKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILE 132
K D+ +VY DI+ ++ K YFR+LP P++TY Y KF +A + ERL + E
Sbjct: 196 GEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE 254
Query: 133 VLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA 192
VL LP +Y TL +LM HL + M+A NL IV+ P L+R +
Sbjct: 255 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDST-----LT 309
Query: 193 AFMEVRVQSIVVEFILTHVDQLF 215
++R Q ++V+ ++ + D LF
Sbjct: 310 TLHDMRYQKLIVQILIENEDVLF 332
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 107 bits (267), Expect = 5e-23
Identities = 128/523 (24%), Positives = 200/523 (38%), Gaps = 95/523 (18%)
Query: 13 AKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFE 71
A++ FG L+EHL+ SG+E+ +++C + E G+ + G++R+ +S ++KL+ +
Sbjct: 245 AEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALD 304
Query: 72 SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131
D + D H V+ K+Y RELP+PL+T+ LY+++ + VQ + ++L +
Sbjct: 305 CSTS---HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLW 361
Query: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191
++LP N+ +L++ L +A S M N+AIV PNLL +++ GT
Sbjct: 362 RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN------EGT 415
Query: 192 AAFMEVRVQ---SIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRP 248
A M V+E I+ H D F P
Sbjct: 416 LAEMAAATSVHVVAVIEPIIQHADWFF------------------------------PEE 445
Query: 249 LPYHLPSILQAGDGPPQMRPYHTIIE----IAEHKRKGSLKVRKWRSIFNLGRSGHETKR 304
+ +++ P +HT + E KR S+ V + +L + K
Sbjct: 446 VEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEG----DLVKKESPPKP 501
Query: 305 KLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASD----EPEGLVGPS---------SPR 351
K P A N + A + AAAG+ +P GPS P
Sbjct: 502 KDPVSAAVPAPGRNNSQI--ASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPA 559
Query: 352 PSPLLP----------ESLENDSIEAAEGEQEPEAEA----LGGTNSEPGTPRAGR--SA 395
P+P P +S S +P + T PG P A SA
Sbjct: 560 PAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSA 619
Query: 396 IRAGGSSRAERCAGVH--ISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQ 453
R SS + A H P +H PPN ++ S GLE P+
Sbjct: 620 PRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPS----EHGLEQPS-- 673
Query: 454 HRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAP 496
H P P P LG P + PA LA P+ P
Sbjct: 674 HTPPQTPTPPSTPPLGKQNP-----SLPAPQTLAGGNPETAQP 711
>gi|5803145 ralA binding protein 1 [Homo sapiens]
Length = 655
Score = 107 bits (266), Expect = 6e-23
Identities = 63/209 (30%), Positives = 111/209 (53%), Gaps = 29/209 (13%)
Query: 17 VFGCDLQEHLQ----HSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFE 71
+FG L + ++ + G +P V + C ++VE+YG+ +GIYR+SG+ S + +L+ ++
Sbjct: 189 IFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYD 248
Query: 72 SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131
E +L + + V+SL K Y R+LP+ LLT L +F EA G E E++ +
Sbjct: 249 REESTNLED----YEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQ 304
Query: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191
+L+ELP NY + +L+ H+ H+ + +T M+ +N++IV +P
Sbjct: 305 RLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPT--------------- 349
Query: 192 AAFMEVRVQSIVVEFILTHVDQLFGGAAL 220
V++ + V+ THV +LFG L
Sbjct: 350 -----VQISNRVLYVFFTHVQELFGNVVL 373
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 107 bits (266), Expect = 6e-23
Identities = 94/383 (24%), Positives = 171/383 (44%), Gaps = 36/383 (9%)
Query: 13 AKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFE 71
A++ FG L+EHL+ SG+E+ +++C + E G+ + G++R+ +S ++KL+ +
Sbjct: 245 AEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALD 304
Query: 72 SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131
D + D H V+ K+Y RELP+PL+T+ LY+++ + VQ + ++L +
Sbjct: 305 CSTS---HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLW 361
Query: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191
++LP N+ +L++ L +A S M N+AIV PNLL +++ GT
Sbjct: 362 RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN------EGT 415
Query: 192 AAFMEVRVQ---SIVVEFILTHVDQLFGGAA---LSGGEVESGWRSLPGTRASGSPED-- 243
A M V+E I+ H D F +S V S + +G+ D
Sbjct: 416 LAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSG 475
Query: 244 LMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETK 303
+ R P + + GD + +++ H+R G+L + F +
Sbjct: 476 TLERKRPASM--AVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGS 533
Query: 304 RKLPRGAE-----DREDKSNKGTLRPAKS---MDSLSAAAGASDEPEGLVGPSSPRPSPL 355
+P G E R + S+ G P+ + S G+ +P+ V + P P
Sbjct: 534 TVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPG-- 591
Query: 356 LPESLENDSIEAAEGEQEPEAEA 378
++ + A G+ +P+A A
Sbjct: 592 ------RNNSQIASGQNQPQAAA 608
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 103 bits (258), Expect = 5e-22
Identities = 59/181 (32%), Positives = 103/181 (56%), Gaps = 8/181 (4%)
Query: 37 LKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQE-FESERKPDLRRDVYLQDIHCVSSLC 94
++ C + VE G+ + G+YR+ GV+S +QKL F + PD+ D+ L D ++S
Sbjct: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457
Query: 95 KAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVH 154
K Y R L +PL+TY+L+ F AV + R+ + ++ +LP N L+ L++HLV
Sbjct: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517
Query: 155 MASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQL 214
++ S Q M NL +++ P L+R+++ AA M ++ Q+IVVE ++ H +++
Sbjct: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE------ETVAAMMNIKFQNIVVEILIEHYEKI 571
Query: 215 F 215
F
Sbjct: 572 F 572
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 103 bits (256), Expect = 9e-22
Identities = 71/221 (32%), Positives = 109/221 (49%), Gaps = 21/221 (9%)
Query: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Q +++G +++VFGC L+ Q G VP L+ C V++ G+ VDGIYR+SG + +
Sbjct: 508 QSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVV 567
Query: 64 QKLRQEFESER------------------KPDLRRDVYLQDIHCVSSLCKAYFRELPDPL 105
QKLR + ER + DL + DIH V+ K + RELP PL
Sbjct: 568 QKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW-DDIHVVTGALKLFLRELPQPL 626
Query: 106 LTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMH 165
+ L F A+ + + L +I E++ +P PN+ TL +L+ HL + + S + M
Sbjct: 627 VPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMT 686
Query: 166 ARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEF 206
NL IV+ P L R + E S A + VQ ++ F
Sbjct: 687 PHNLGIVFGPTLFRPEQ-ETSDPAAHALYPGQLVQLMLTNF 726
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 103 bits (256), Expect = 9e-22
Identities = 127/499 (25%), Positives = 219/499 (43%), Gaps = 47/499 (9%)
Query: 6 KGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQ 64
K +++ ++ FG L+EHL SG+E+ +++C + E G+ + G++R++ +S ++
Sbjct: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
Query: 65 KLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEP 124
KL+ + D++ Y D H ++ K+Y RELP+PL+T+ LYD++ +A VQ +
Sbjct: 301 KLKAALDC-CVVDVQE--YSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQD 357
Query: 125 ERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIE 184
++L + +LP N+ + +L++ L ++ + M N+AIV PNLL +
Sbjct: 358 KKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP---Q 414
Query: 185 ASGFNGTAAFMEVRVQSI-VVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPED 243
A G N T V +Q + ++E I+ H D F GE+E T GSP
Sbjct: 415 AEG-NITEMMTTVSLQIVGIIEPIIQHADWFF------PGEIEFNI-----TGNYGSPVH 462
Query: 244 LMPRPLPYHLPS--ILQAGDGPPQM--RPYHTIIE--IAEHKRKGSLKVRKWRSIFNLGR 297
+ +PS + A P+ RP + + E +K L R I ++G
Sbjct: 463 VNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGL-----RKIQSMGV 517
Query: 298 SGHETKRKLPRGAE-DREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPL- 355
+T RG+ R+ +++P L+A + + L P++P SP
Sbjct: 518 RVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSG 577
Query: 356 --LPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHIS 413
L E S ++ E P + G S GT AG + G A+ A S
Sbjct: 578 LGLQPGPERTSTTKSK-ELSPGSAQKGSPGSSQGTACAG---TQPGAQPGAQPGASPSPS 633
Query: 414 DPYNVNLPLHITSI----LSVPPNIISNV--SLARLTRGLECPALQHRPSPASGPGP-GP 466
P P + + +PP + ++A + G P + P+P S P P G
Sbjct: 634 QPPADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSP-VSLSPTPPSTPSPYGL 692
Query: 467 GLGPGPPDEKLEASPASSP 485
G + SPA++P
Sbjct: 693 SYPQGYSLASGQLSPAAAP 711
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 103 bits (256), Expect = 9e-22
Identities = 71/221 (32%), Positives = 109/221 (49%), Gaps = 21/221 (9%)
Query: 5 QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNI 63
Q +++G +++VFGC L+ Q G VP L+ C V++ G+ VDGIYR+SG + +
Sbjct: 324 QSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVV 383
Query: 64 QKLRQEFESER------------------KPDLRRDVYLQDIHCVSSLCKAYFRELPDPL 105
QKLR + ER + DL + DIH V+ K + RELP PL
Sbjct: 384 QKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW-DDIHVVTGALKLFLRELPQPL 442
Query: 106 LTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMH 165
+ L F A+ + + L +I E++ +P PN+ TL +L+ HL + + S + M
Sbjct: 443 VPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMT 502
Query: 166 ARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEF 206
NL IV+ P L R + E S A + VQ ++ F
Sbjct: 503 PHNLGIVFGPTLFRPEQ-ETSDPAAHALYPGQLVQLMLTNF 542
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 102 bits (253), Expect = 2e-21
Identities = 84/288 (29%), Positives = 133/288 (46%), Gaps = 30/288 (10%)
Query: 7 GKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQK 65
G ++ A+ +FG D + + +EVP V+ C +E + V GIYR+SG +++
Sbjct: 538 GHRRLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVER 597
Query: 66 LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV----- 120
L Q FE+ R ++ H VSS+ K + +EL +P++ + LYD F
Sbjct: 598 LCQAFENGRA---LVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADP 654
Query: 121 -------QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVW 173
PE + + +L +LP NY TL L+ HL +A+ + M A NL IV+
Sbjct: 655 GDDPGTPSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVF 714
Query: 174 APNLLRSKD-IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSL 232
P LLR D A+ ++ Q+ +VEF++ H +Q+FG L S
Sbjct: 715 GPTLLRPPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSS 774
Query: 233 PGTRASGSPEDLMPRPLPYHL-----PSILQAGDGP-PQMRPYHTIIE 274
P + P +P P HL P +L + GP PQ +H+ +E
Sbjct: 775 P----APGPLTTSSQPPPPHLDPDSQPPVLASDPGPDPQ---HHSTLE 815
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 101 bits (252), Expect = 3e-21
Identities = 65/203 (32%), Positives = 102/203 (50%), Gaps = 4/203 (1%)
Query: 16 RVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFESER 74
RV+G L HLQ G+E+ +++C + G+ + G++RL+ +S +++L+Q S+
Sbjct: 272 RVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDP 331
Query: 75 KPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVL 134
+ + D H V+ K+Y RELP+PL+T+ LYD + A ++ RL + EV
Sbjct: 332 HS---LEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVC 388
Query: 135 RELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAF 194
LP N L +LM+ L +A M N+AIV PNLL + E AA
Sbjct: 389 SRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAAS 448
Query: 195 MEVRVQSIVVEFILTHVDQLFGG 217
+ VVE ++ D LF G
Sbjct: 449 VSSIQVVGVVEALIQSADTLFPG 471
Score = 35.0 bits (79), Expect = 0.31
Identities = 37/153 (24%), Positives = 53/153 (34%), Gaps = 14/153 (9%)
Query: 450 PALQHRPSPASGPGPGPGLGPGPPDEKLEAS----PASSPLADSGPDDLAPALEDSLSQE 505
PA P+PA P P P L E+ E+ PAS + S P+ AP
Sbjct: 507 PATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAP--------- 557
Query: 506 VQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEE 565
V+D + + + P + +++ PG PG VG +
Sbjct: 558 VEDMARRTKRPAPARPT-MPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRA 616
Query: 566 FSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRP 598
+V PPL A+ S S A P P
Sbjct: 617 PTVPPPLPPTPPQPARRQSRRSPASPSPASPGP 649
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 101 bits (251), Expect = 4e-21
Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 3/180 (1%)
Query: 8 KKKGSAKER-VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
K+ S K+ VFG + + +VP +++ C E +E G+ + GIYR+SGV+++IQ
Sbjct: 997 KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1056
Query: 66 LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
L+ F+ K D+ + D++ ++ K YFRELP+PL T Y FAE + +
Sbjct: 1057 LKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVA 1115
Query: 126 RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
+ +L +L LP N T FL+ HL +A A M NLA V+ P LLR + E+
Sbjct: 1116 KESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1175
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 101 bits (251), Expect = 4e-21
Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 3/180 (1%)
Query: 8 KKKGSAKER-VFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
K+ S K+ VFG + + +VP +++ C E +E G+ + GIYR+SGV+++IQ
Sbjct: 1041 KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1100
Query: 66 LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
L+ F+ K D+ + D++ ++ K YFRELP+PL T Y FAE + +
Sbjct: 1101 LKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVA 1159
Query: 126 RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
+ +L +L LP N T FL+ HL +A A M NLA V+ P LLR + E+
Sbjct: 1160 KESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1219
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 100 bits (248), Expect = 8e-21
Identities = 63/189 (33%), Positives = 102/189 (53%), Gaps = 6/189 (3%)
Query: 28 HSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQEFESERKPDLRRDVYLQD 86
H+ + +P ++ C + VEE G+ GIYR+ G ++ I +++E +D +D
Sbjct: 1156 HTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRD 1215
Query: 87 IHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLE 146
++ +SSL K++FR+LP+PL T Y F EA + +RL + ++ +LP +Y TL+
Sbjct: 1216 LNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLK 1275
Query: 147 FLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEF 206
FL HL +A S + M RNLAIV+ P L+R+ S N T + Q +VE
Sbjct: 1276 FLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRT-----SEDNMTHMVTHMPDQYKIVET 1330
Query: 207 ILTHVDQLF 215
++ H D F
Sbjct: 1331 LIQHHDWFF 1339
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,433,810
Number of Sequences: 37866
Number of extensions: 2760416
Number of successful extensions: 15421
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 485
Number of HSP's that attempted gapping in prelim test: 12833
Number of HSP's gapped (non-prelim): 2572
length of query: 890
length of database: 18,247,518
effective HSP length: 111
effective length of query: 779
effective length of database: 14,044,392
effective search space: 10940581368
effective search space used: 10940581368
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.