Guide to the Human Genome
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Search of human proteins with 13899255

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13899255 membrane frizzled-related protein [Homo sapiens]
         (579 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13899255 membrane frizzled-related protein [Homo sapiens]         1231   0.0  
gi|6912724 tolloid-like 2 [Homo sapiens]                              166   5e-41
gi|22547221 tolloid-like 1 [Homo sapiens]                             160   2e-39
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   155   1e-37
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   154   3e-37
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   154   3e-37
gi|72384339 CUB domain containing protein 2 [Homo sapiens]            152   1e-36
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]      143   5e-34
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]      130   3e-30
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   125   1e-28
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   125   1e-28
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   125   1e-28
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]           123   4e-28
gi|126091152 cubilin [Homo sapiens]                                   123   5e-28
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          122   9e-28
gi|7305525 low density lipoprotein-related protein 12 isoform a ...   122   1e-27
gi|167555125 low density lipoprotein receptor-related protein 3 ...   121   2e-27
gi|11415040 matriptase [Homo sapiens]                                 121   2e-27
gi|208973262 low density lipoprotein-related protein 12 isoform ...   121   2e-27
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]           109   8e-24
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]           109   8e-24
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]           109   8e-24
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]           109   8e-24
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]           109   8e-24
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]           109   8e-24
gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Ho...   107   4e-23
gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3 pre...   102   7e-22
gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2 pre...   102   7e-22
gi|29244926 corin [Homo sapiens]                                       97   5e-20
gi|66864913 neuropilin 1 isoform c [Homo sapiens]                      94   3e-19

>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 1231 bits (3185), Expect = 0.0
 Identities = 579/579 (100%), Positives = 579/579 (100%)

Query: 1   MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLR 60
           MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLR
Sbjct: 1   MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLR 60

Query: 61  PDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTIT 120
           PDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTIT
Sbjct: 61  PDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTIT 120

Query: 121 TSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH 180
           TSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH
Sbjct: 121 TSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH 180

Query: 181 AIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSS 240
           AIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSS
Sbjct: 181 AIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSS 240

Query: 241 VEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG 300
           VEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG
Sbjct: 241 VEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG 300

Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
           CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE
Sbjct: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360

Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
           VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP
Sbjct: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420

Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYN 480
           CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYN
Sbjct: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYN 480

Query: 481 TTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRS 540
           TTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRS
Sbjct: 481 TTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRS 540

Query: 541 VCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP 579
           VCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP
Sbjct: 541 VCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP 579


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  166 bits (420), Expect = 5e-41
 Identities = 106/326 (32%), Positives = 155/326 (47%), Gaps = 31/326 (9%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++TCGG ++   G   SPNYPD Y P+  CVW I V+    + L  +A  IE   SC +D
Sbjct: 461 EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520

Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
            LE+   P  E  L+   CG   P  + ++++ L + FVSD S+   GF A +     + 
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC 580

Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
             P  G C H   RC   +     +   G+   A   D+  C      CGG +T L GT 
Sbjct: 581 SWPDHGGCEH---RCVNTLGSYKCACDPGYELAA---DKKMCEV---ACGGFITKLNGTI 631

Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
           ++P + ++YP    C W +  PA + I LQF  F LE  D CK+D+VEV    S  A  L
Sbjct: 632 TSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDA-KL 690

Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ--- 429
            GRFCG+E P  + S  + + V F++D+ +S  GF A    F + ++ C      CQ   
Sbjct: 691 HGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRA---HFFSDKDECAKDNGGCQHEC 747

Query: 430 -------AGGCKGVQWMCDMWRDCTD 448
                     C+   W+ +   DC +
Sbjct: 748 VNTFGSYLCRCRNGYWLHENGHDCKE 773



 Score =  149 bits (377), Expect = 5e-36
 Identities = 83/274 (30%), Positives = 141/274 (51%), Gaps = 14/274 (5%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CGG ++   G  +SP +P  YP N +CVW +     + I L+ E   +E    C +D +E
Sbjct: 620 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVE 679

Query: 204 LSP--EPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
           +     P+  L  R CG   P  + + ++++ V F SD++V   GF A + +    +  C
Sbjct: 680 VRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS---DKDEC 736

Query: 261 AHDEFRCD-QLICLLPDSVCDGFANCADGS--DETNCSAKFSGCGGNLTGLQGTFSTPSY 317
           A D   C  + +      +C     C +G    E     K +GC   ++ ++GT ++P++
Sbjct: 737 AKDNGGCQHECVNTFGSYLC----RCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNW 792

Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
             +YP +  CTW+IS  AGH ++L F+ F +E   EC +D++E+Y+   S A  +LGRFC
Sbjct: 793 PDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLA-PILGRFC 851

Query: 378 GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
           G++ P   V+S   + + F +D  +   GF A +
Sbjct: 852 GSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH 885



 Score =  122 bits (306), Expect = 9e-28
 Identities = 80/278 (28%), Positives = 114/278 (41%), Gaps = 55/278 (19%)

Query: 141  QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
            ++ C   +S   G  +SPN+PD YP    C W+I     H ++L      IE    C +D
Sbjct: 773  EAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYD 832

Query: 201  RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
             LE+   P+   P+L R CG   P     + S + + F SD+SV+  GF A +       
Sbjct: 833  HLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHS------ 886

Query: 258  GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
                                                     + CGG L     T    S+
Sbjct: 887  -----------------------------------------TECGGRLKAEVQTKELYSH 905

Query: 318  LQ----QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
             Q     YP +  C W I    G+ +EL F  F +E + +C +DY+E Y+   S A   L
Sbjct: 906  AQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSA-PRL 964

Query: 374  GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
            GRFCG+ P   + S+   L + FRTD  I+  GF A Y
Sbjct: 965  GRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002



 Score =  120 bits (301), Expect = 3e-27
 Identities = 83/290 (28%), Positives = 125/290 (43%), Gaps = 55/290 (18%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CG  L    G FS+P +P+ YP  +HCVW I V     I L   ++ +     C +D +E
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410

Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
           +      + PLL R CG ++P P ++T+ S L V F S S++ G GF A Y+A       
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTD-SRLWVEFRSSSNILGKGFFAAYEAT------ 463

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
                                                    CGG++    G   +P+Y  
Sbjct: 464 -----------------------------------------CGGDMNKDAGQIQSPNYPD 482

Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
            Y     C W I+V  G  + L F  F +E  D C +DY+EV +  +  + +L+G FCG 
Sbjct: 483 DYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEES-ALIGHFCGY 541

Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
           E P  + SS + L + F +D  I+  GF+A +  F   +    P    C+
Sbjct: 542 EKPEDVKSSSNRLWMKFVSDGSINKAGFAANF--FKEVDECSWPDHGGCE 589



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 48/117 (41%), Positives = 55/117 (47%), Gaps = 1/117 (0%)

Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
           K   CG  L    G FS P +   YP    C W ISV  G  I L F +  L     C +
Sbjct: 347 KCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWY 406

Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
           DYVEV +     A  LLGRFCG + P  LVS+   L V FR+   I   GF A Y A
Sbjct: 407 DYVEVRDGYWRKA-PLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEA 462



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 7/126 (5%)

Query: 132  QESGVSPSPQSTCGGLLSGP---RGFFSSPNYPDP-YPPNTHCVWHIQVATDHAIQLKIE 187
            Q  G      + CGG L      +  +S   + D  YP    C W I     + ++L   
Sbjct: 877  QRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFR 936

Query: 188  ALSIESVASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
               +E  A C +D +E     +   P L R CG  P   + +    L++ F +D ++   
Sbjct: 937  TFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKK 996

Query: 245  GFHAWY 250
            GFHA Y
Sbjct: 997  GFHARY 1002


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  160 bits (406), Expect = 2e-39
 Identities = 99/297 (33%), Positives = 146/297 (49%), Gaps = 21/297 (7%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++ CGG +    G   SPNYPD Y P   CVW I V+  + + L  ++  IE   +C +D
Sbjct: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518

Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
            LE+        PL+ R CG   P  + + ++ L + FVSD +V   GF A +     + 
Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578

Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
             P RG C   E RC   +  L    C        G D  +C A    CGG LT L GT 
Sbjct: 579 AKPDRGGC---EQRC---LNTLGSYQCACEPGYELGPDRRSCEA---ACGGLLTKLNGTI 629

Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
           +TP + ++YP    C W +  P  + I ++F  F LE  + CK+DYVE++   SS +  L
Sbjct: 630 TTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSES-KL 688

Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
            G+FCGAE P  + S  + + + F++D+ +S  GF A    F + ++ C      CQ
Sbjct: 689 HGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKA---HFFSDKDECSKDNGGCQ 742



 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/278 (29%), Positives = 141/278 (50%), Gaps = 12/278 (4%)

Query: 139 SPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCL 198
           S ++ CGGLL+   G  ++P +P  YPPN +CVW +   T + I +K E   +E    C 
Sbjct: 613 SCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCK 672

Query: 199 FDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAP 255
           +D +E+      E  L  + CG   P  + +  +++ + F SD++V   GF A + +   
Sbjct: 673 YDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS--- 729

Query: 256 GRGSCAHDEFRCDQLICLLPDSVCDGFANCADG--SDETNCSAKFSGCGGNLTGLQGTFS 313
            +  C+ D   C Q  C+  +++      C +G    +     K + C   +    G  +
Sbjct: 730 DKDECSKDNGGC-QHECV--NTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLIT 786

Query: 314 TPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
           +P++  +YP +  CTW IS   GH I+L F  F +E   EC +D++EV++  +  +  +L
Sbjct: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS-PIL 845

Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
           GR CG + P  LV++ +++ V F +D  +   GF AT+
Sbjct: 846 GRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883



 Score =  120 bits (300), Expect = 4e-27
 Identities = 80/294 (27%), Positives = 124/294 (42%), Gaps = 58/294 (19%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CG  L    G  SSP +P+ YP  THC+W + V     I L    + +   + C +D +E
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408

Query: 204 LSPE--PEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
           +      + PLL R CG   P  L +  S + + F S S+  G GF A Y+A+       
Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI------- 461

Query: 261 AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
                                                   CGG +   +G   +P+Y   
Sbjct: 462 ----------------------------------------CGGEIRKNEGQIQSPNYPDD 481

Query: 321 YPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAE 380
           Y     C W I+V   + + L F +F +E  D C +DY+EV + +S  +  L+GRFCG +
Sbjct: 482 YRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENS-PLIGRFCGYD 540

Query: 381 PPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCK 434
            P  + S+ + L + F +D  ++  GF+A    F   E+ C   +     GGC+
Sbjct: 541 KPEDIRSTSNTLWMKFVSDGTVNKAGFAAN---FFKEEDECAKPD----RGGCE 587



 Score =  119 bits (297), Expect = 1e-26
 Identities = 79/274 (28%), Positives = 113/274 (41%), Gaps = 47/274 (17%)

Query: 141  QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
            ++ C   +  P G  +SPN+PD YP    C W I     H I+L      IE    C +D
Sbjct: 771  EAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYD 830

Query: 201  RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
             LE+      + P+L R+CG   P  L    + + V FVSD+SV+  GF A +       
Sbjct: 831  HLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH------- 883

Query: 258  GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
                               + C G         +    A+F   G N             
Sbjct: 884  ------------------STECGGRLKAESKPRDLYSHAQF---GDN------------- 909

Query: 318  LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
               YP Q+ C W +    G  +EL F  F +E + +C +DYVE+++   S A   LGRFC
Sbjct: 910  --NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVG-LGRFC 966

Query: 378  GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
            G+ PP  + S    + + F TD  I+  GF   Y
Sbjct: 967  GSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 7/129 (5%)

Query: 132  QESGVSPSPQSTCGGLL---SGPRGFFSSPNYPDP-YPPNTHCVWHIQVATDHAIQLKIE 187
            Q  G   +  + CGG L   S PR  +S   + D  YP    C W +       ++L  +
Sbjct: 875  QRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQ 934

Query: 188  ALSIESVASCLFDRLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
               +E  A C +D +EL    +   +   R CG  PP  + +    +L+ F +D ++   
Sbjct: 935  TFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKK 994

Query: 245  GFHAWYQAM 253
            GFH  Y+++
Sbjct: 995  GFHIRYKSI 1003


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  155 bits (392), Expect = 1e-37
 Identities = 96/297 (32%), Positives = 142/297 (47%), Gaps = 21/297 (7%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++ CGG +    G   SPNYPD Y P+  C+W IQV+    + L  ++  IE   SC +D
Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491

Query: 201 RLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
            LE+     E    + R CG   P  + + +S L + FVSD S+   GF   +     + 
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551

Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
             P RG C   E RC   +  L    C          D+  C A    CGG LT L G+ 
Sbjct: 552 SRPNRGGC---EQRC---LNTLGSYKCSCDPGYELAPDKRRCEA---ACGGFLTKLNGSI 602

Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
           ++P + ++YP    C W +  P  + I LQF  F  E  D CK+D+VEV  +  +    L
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661

Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
            G+FCG+E P  + S ++ + V F++D+ +S  GF A    F + ++ C      CQ
Sbjct: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKA---HFFSDKDECSKDNGGCQ 715



 Score =  139 bits (349), Expect = 9e-33
 Identities = 84/298 (28%), Positives = 145/298 (48%), Gaps = 40/298 (13%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++ CGG L+   G  +SP +P  YPPN +C+W +   T + I L+ +    E    C +D
Sbjct: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647

Query: 201 RLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
            +E+            + CG   P  + +  +++ V F SD++V   GF A + +    +
Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS---DK 704

Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCAD--GSDETNCSAKF-----------SGCGGN 304
             C+ D   C Q              +C +  GS E  C + F           +GC   
Sbjct: 705 DECSKDNGGCQQ--------------DCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHK 750

Query: 305 LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYET 364
           +T   GT ++P++  +YP +  CTW IS   GH ++L F    +E+Q EC +D++EV++ 
Sbjct: 751 VTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDG 810

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
             + A  +LGRFCG++ P  ++++   + + F +D+ +   GF A++    ATE  CG
Sbjct: 811 RDAKA-PVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH----ATE--CG 861



 Score =  117 bits (293), Expect = 3e-26
 Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CG  L    G FSSP YP+ Y  + HCVW I V     I L   +L +     C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
           +      + PL  R CG ++P P ++T+ S L V F S S+  G GF A Y+A+      
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
                                                    CGG++    G   +P+Y  
Sbjct: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453

Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
            Y    +C W I V  G  + L F +F +E  D C +DY+EV +  S  + +L+GR+CG 
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512

Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
           E P  + S+   L + F +D  I+  GF+  +  F   +    P+   C+
Sbjct: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560



 Score =  109 bits (273), Expect = 6e-24
 Identities = 74/278 (26%), Positives = 115/278 (41%), Gaps = 55/278 (19%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++ C   ++   G  +SPN+PD YP    C W I     H ++L    + IES   C +D
Sbjct: 744 EAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYD 803

Query: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
            LE+    + + P+L R CG   P  +    S + + F SD+SV+  GF A         
Sbjct: 804 HLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQA--------- 854

Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
                                                 +  + CGG +     T    S+
Sbjct: 855 --------------------------------------SHATECGGQVRADVKTKDLYSH 876

Query: 318 LQ----QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
            Q     YP  + C W I    G+ +EL F  F +E + +C +DY+E+++   S A   L
Sbjct: 877 AQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTA-PRL 935

Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
           GR+CG+ PP  + S+   + V F +D  I+  GF   Y
Sbjct: 936 GRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)

Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
           K   CG  L    G FS+P Y   Y   + C W ISV  G  I L F +  L     C +
Sbjct: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377

Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
           DYVEV +     A  L GRFCG++ P  +VS+   L V FR+       GF A Y A
Sbjct: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/126 (27%), Positives = 53/126 (42%), Gaps = 7/126 (5%)

Query: 132 QESGVSPSPQSTCGGLLSGP---RGFFSSPNYPDP-YPPNTHCVWHIQVATDHAIQLKIE 187
           Q  G   S  + CGG +      +  +S   + D  YP    C W I     + ++L  +
Sbjct: 848 QRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQ 907

Query: 188 ALSIESVASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
              +E    C +D +EL    +   P L R CG  PP  + +    +LV F SD ++   
Sbjct: 908 TFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKK 967

Query: 245 GFHAWY 250
           GFH  Y
Sbjct: 968 GFHLRY 973


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  154 bits (388), Expect = 3e-37
 Identities = 92/281 (32%), Positives = 138/281 (49%), Gaps = 18/281 (6%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++ CGG +    G   SPNYPD Y P+  C+W IQV+    + L  ++  IE   SC +D
Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491

Query: 201 RLELSP---EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
            LE+     E    + R CG   P  + + +S L + FVSD S+   GF   +     + 
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551

Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
             P RG C   E RC   +     S   G+    D   +  C A    CGG LT L G+ 
Sbjct: 552 SRPNRGGC---EQRCLNTLGSYKCSCDPGYELAPD---KRRCEA---ACGGFLTKLNGSI 602

Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
           ++P + ++YP    C W +  P  + I LQF  F  E  D CK+D+VEV  +  +    L
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661

Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
            G+FCG+E P  + S ++ + V F++D+ +S  GF A + +
Sbjct: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702



 Score =  117 bits (293), Expect = 3e-26
 Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CG  L    G FSSP YP+ Y  + HCVW I V     I L   +L +     C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
           +      + PL  R CG ++P P ++T+ S L V F S S+  G GF A Y+A+      
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
                                                    CGG++    G   +P+Y  
Sbjct: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453

Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
            Y    +C W I V  G  + L F +F +E  D C +DY+EV +  S  + +L+GR+CG 
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512

Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
           E P  + S+   L + F +D  I+  GF+  +  F   +    P+   C+
Sbjct: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)

Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
           K   CG  L    G FS+P Y   Y   + C W ISV  G  I L F +  L     C +
Sbjct: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377

Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
           DYVEV +     A  L GRFCG++ P  +VS+   L V FR+       GF A Y A
Sbjct: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  154 bits (388), Expect = 3e-37
 Identities = 92/281 (32%), Positives = 138/281 (49%), Gaps = 18/281 (6%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++ CGG +    G   SPNYPD Y P+  C+W IQV+    + L  ++  IE   SC +D
Sbjct: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491

Query: 201 RLELSP---EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
            LE+     E    + R CG   P  + + +S L + FVSD S+   GF   +     + 
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551

Query: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
             P RG C   E RC   +     S   G+    D   +  C A    CGG LT L G+ 
Sbjct: 552 SRPNRGGC---EQRCLNTLGSYKCSCDPGYELAPD---KRRCEA---ACGGFLTKLNGSI 602

Query: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
           ++P + ++YP    C W +  P  + I LQF  F  E  D CK+D+VEV  +  +    L
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKL 661

Query: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
            G+FCG+E P  + S ++ + V F++D+ +S  GF A + +
Sbjct: 662 HGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702



 Score =  117 bits (293), Expect = 3e-26
 Identities = 83/290 (28%), Positives = 124/290 (42%), Gaps = 55/290 (18%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CG  L    G FSSP YP+ Y  + HCVW I V     I L   +L +     C +D +E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 204 LSPE--PEGPLL-RVCG-RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
           +      + PL  R CG ++P P ++T+ S L V F S S+  G GF A Y+A+      
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTD-SRLWVEFRSSSNWVGKGFFAVYEAI------ 434

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
                                                    CGG++    G   +P+Y  
Sbjct: 435 -----------------------------------------CGGDVKKDYGHIQSPNYPD 453

Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
            Y    +C W I V  G  + L F +F +E  D C +DY+EV +  S  + +L+GR+CG 
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS-TLIGRYCGY 512

Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
           E P  + S+   L + F +D  I+  GF+  +  F   +    P+   C+
Sbjct: 513 EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVDECSRPNRGGCE 560



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 45/117 (38%), Positives = 55/117 (47%), Gaps = 1/117 (0%)

Query: 297 KFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
           K   CG  L    G FS+P Y   Y   + C W ISV  G  I L F +  L     C +
Sbjct: 318 KCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377

Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
           DYVEV +     A  L GRFCG++ P  +VS+   L V FR+       GF A Y A
Sbjct: 378 DYVEVRDGFWRKA-PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 3/121 (2%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           ++ CGG L+   G  +SP +P  YPPN +C+W +   T + I L+ +    E    C +D
Sbjct: 588 EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYD 647

Query: 201 RLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
            +E+            + CG   P  + +  +++ V F SD++V   GF A + ++  G 
Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707

Query: 258 G 258
           G
Sbjct: 708 G 708


>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
          Length = 449

 Score =  152 bits (383), Expect = 1e-36
 Identities = 96/280 (34%), Positives = 125/280 (44%), Gaps = 55/280 (19%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CGG+LS P G FSSPN+P  YP NT C W I VA   ++ L   A  +E   +C FD LE
Sbjct: 30  CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89

Query: 204 L----SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
           +    SP+    L R CG+VPPP   ++   + V+F SD  V   GF A YQ        
Sbjct: 90  IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK------- 142

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
                                                    CGG LTGL G  ++P Y  
Sbjct: 143 ---------------------------------------DVCGGVLTGLSGVLTSPEYPN 163

Query: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG-RFCG 378
            YP+ + C W I       ++L F +F +E  +EC +DYV V      G     G  +CG
Sbjct: 164 NYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL----GGPGPTRGHHYCG 219

Query: 379 AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
           +  PP LVS  HEL V+F++D  I   GF A Y +    E
Sbjct: 220 STRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQE 259



 Score =  128 bits (322), Expect = 1e-29
 Identities = 86/302 (28%), Positives = 130/302 (43%), Gaps = 66/302 (21%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           +  CGG+L+G  G  +SP YP+ YP +  C W I+ A    ++L      +E    C +D
Sbjct: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201

Query: 201 RLELSPEPEGPLL--RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRG 258
            + +   P GP      CG   PPTL +    L VVF SD ++ G GF A+Y        
Sbjct: 202 YVAVLGGP-GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY-------- 252

Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG-CGGNLTGLQGTFSTPSY 317
                                                  FSG C      ++G FS+P Y
Sbjct: 253 ---------------------------------------FSGECQEVYMAMRGNFSSPQY 273

Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE----CKFDYVEVYETSSSGAFSLL 373
              YP+ + C W I +P G+ +++ F +  LE  +     C FD++  ++ +S  A  LL
Sbjct: 274 PSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEA-PLL 332

Query: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGC 433
           G +CG   PP + SSH++L +L  TD   +  GFS  Y+            +L C +G  
Sbjct: 333 GNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG----------GQLGCGSGST 382

Query: 434 KG 435
           +G
Sbjct: 383 EG 384


>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
          Length = 415

 Score =  143 bits (360), Expect = 5e-34
 Identities = 87/292 (29%), Positives = 133/292 (45%), Gaps = 43/292 (14%)

Query: 124 AAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQ 183
           AA T   +Q+S     P  TCGG+L+G  GF  S  +P  YPPN+ C W I V     + 
Sbjct: 15  AAATQLSRQQS--PERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVV 72

Query: 184 LKIEALSIESVASCLFDRLEL-SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSV 241
           L    + +ES   C +D +++ +    G  + R CG   P  L ++ + ++V  +SD++ 
Sbjct: 73  LNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132

Query: 242 EGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGC 301
            G GF A + A  P          R DQ                               C
Sbjct: 133 AGNGFMAMFSAAEPNE--------RGDQY------------------------------C 154

Query: 302 GGNLTGLQGTFSTPSYL-QQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
           GG L    G+F TP++  + YP  + C WHI  P    IEL+F  F +E  + C++DYV 
Sbjct: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214

Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYL 412
           V+          +G++CG  PP  +VS  +EL + F +D  +++ GF   Y+
Sbjct: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI 266



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 49/141 (34%), Positives = 69/141 (48%), Gaps = 6/141 (4%)

Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
           CGG LTG  G   +  +   YP    CTW I+VP G  + L F    LE+ + C++D+V+
Sbjct: 33  CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92

Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
           VY   ++G    +GRFCG   P  LVSS +++ V   +D   +  GF A + A    E  
Sbjct: 93  VYNGHANG--QRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERG 150

Query: 421 ---CGPSELSCQAGGCKGVQW 438
              CG   L   +G  K   W
Sbjct: 151 DQYCG-GLLDRPSGSFKTPNW 170


>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
          Length = 449

 Score =  130 bits (328), Expect = 3e-30
 Identities = 89/311 (28%), Positives = 127/311 (40%), Gaps = 46/311 (14%)

Query: 105 LPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPY 164
           LPA   T +   P +T    A  P  Q ++     P   CGG + G  G+ +S  +P+ Y
Sbjct: 2   LPAA--TASLLGPLLTA--CALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLY 57

Query: 165 PPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL---SPEPEGPLLRVCGRVPP 221
           PPN  C+W I V     + L      +E   +C +D LE+   S      L R CG   P
Sbjct: 58  PPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP 117

Query: 222 PTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDG 281
             L    + + +   +D    G GF  WY   A                           
Sbjct: 118 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS------------------------- 152

Query: 282 FANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ-YPHQLLCTWHISVPAGHSIE 340
                          +   CGG L   QGT +TP++ +  YP  + C+WHI  P    I 
Sbjct: 153 -------------GTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIA 199

Query: 341 LQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDH 400
           L F  F LE    C++D V V+  + S     LG+FCG   P  + S  +EL V F +D 
Sbjct: 200 LTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDL 259

Query: 401 GISSGGFSATY 411
            +++ GFSA+Y
Sbjct: 260 SVTADGFSASY 270



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 43/125 (34%), Positives = 63/125 (50%), Gaps = 4/125 (3%)

Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
           CGG++ G  G  ++  +   YP    C W I+VP G ++ L F  F LE    C++D +E
Sbjct: 37  CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96

Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY--LAFNATE 418
           V+  S +     LGRFCG   P  LV+  +++ +   TD G    GF   Y   A + TE
Sbjct: 97  VFAGSGTSG-QRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTE 155

Query: 419 NP-CG 422
           +  CG
Sbjct: 156 HQFCG 160



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 48/159 (30%), Positives = 69/159 (43%), Gaps = 5/159 (3%)

Query: 103 SPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPD 162
           +PL A G   T    T   +   G          S +    CGG L   +G  ++PN+P+
Sbjct: 118 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE 177

Query: 163 P-YPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELS----PEPEGPLLRVCG 217
             YPP   C WHI    D  I L  E   +E    C +D + +      +    L + CG
Sbjct: 178 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCG 237

Query: 218 RVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
              P ++++  + LLV FVSD SV   GF A Y+ +  G
Sbjct: 238 DAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  125 bits (313), Expect = 1e-28
 Identities = 93/302 (30%), Positives = 133/302 (44%), Gaps = 40/302 (13%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            CGG+L+  +G   SP YP+PY  N +CVW I V     IQ+++ + + E     L D  +
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSL-DFYD 1957

Query: 204  LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
                    L    G   P  LN+ +++L + F SD SV   GFH  Y A+  G  SC   
Sbjct: 1958 GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI--GLDSCPEP 2015

Query: 264  E-------------------FRCDQLICLLPDSVCDGFANCADGSDET------NCSAKF 298
            +                   F+CDQ   L   S       C  G           C A+ 
Sbjct: 2016 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS----HITCMPGPVRRWNYPIPICLAQ- 2070

Query: 299  SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
              CGG ++   G   +P +   YP  L CTW I++P G  + LQF NFS E       DY
Sbjct: 2071 --CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124

Query: 359  VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
            +EV  + SS   +++GR  G + P  L S+ HE ++ F +D+  +  GF   Y A+    
Sbjct: 2125 LEV-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2183

Query: 419  NP 420
             P
Sbjct: 2184 CP 2185



 Score =  117 bits (293), Expect = 3e-26
 Identities = 95/306 (31%), Positives = 131/306 (42%), Gaps = 45/306 (14%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHI-QVATDHAIQLKIEALSIESVASCLFDR 201
           TCG  L GP G F+SPN+P  Y  N  CVW I  V T+  IQ+  E   +E      +D 
Sbjct: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 562

Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
           L +       +P   L  + G   P  + + +S + +   +D SV   GF   Y+ +   
Sbjct: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE-- 620

Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFAN-------CADGSD---------------ETNC 294
           + SC       D    L      DGF+N       C  G +                 N 
Sbjct: 621 KESCG------DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANI 674

Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
                 C  N T   GT  +P Y + Y + L C W I    G  I L F++F LE+Q   
Sbjct: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ--- 731

Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
            FD++ V +  S  +  +LG F GAE P HL S+ H L + F+ DH +S  GF+ TY  F
Sbjct: 732 -FDFLAVKDGDSPES-PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF 789

Query: 415 NATENP 420
              E P
Sbjct: 790 GHNECP 795



 Score =  108 bits (271), Expect = 1e-23
 Identities = 98/349 (28%), Positives = 147/349 (42%), Gaps = 45/349 (12%)

Query: 99   GASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSP 158
            G+S S +   G   T  T TIT     G       SG+ P   + CGG  S P G   SP
Sbjct: 813  GSSISVICEEGFIKTQGTETITCILMDGKVMW---SGLIPKCGAPCGGHFSAPSGVILSP 869

Query: 159  NYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPE--GPLL-RV 215
             +P  Y  + +C W I+    H+I++  E    E      +D LE+   P    PLL   
Sbjct: 870  GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSY 925

Query: 216  CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC------------AHD 263
             G   P  L ++++ + ++F +D+S    GF   Y+++     SC             HD
Sbjct: 926  NGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD 985

Query: 264  -------EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
                    F CD    L  +       N         C A    CGG++ G  GT  +P 
Sbjct: 986  FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL---CGGDVRGPSGTILSPG 1042

Query: 317  YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL-LGR 375
            Y + YP+ L CTW + V  G  ++  FH F LE       DY+ + E   +G+F+  L R
Sbjct: 1043 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITE---NGSFTQPLAR 1095

Query: 376  FCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYLAFNATENPC 421
              G++ PP +   +  +    + F +D  IS  GF+ T+  +N    PC
Sbjct: 1096 LTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNL--EPC 1142



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 84/308 (27%), Positives = 125/308 (40%), Gaps = 38/308 (12%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
           TCGG L G  G   SP +P  YP   +C W I     + IQ+  ++ ++E      +D L
Sbjct: 24  TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 79

Query: 203 EL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM------ 253
            L    P P     R+ G   PP + +  S   +   SD +V   GF  +Y+ +      
Sbjct: 80  SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139

Query: 254 ---APGRGSCAHDEFRCDQLI--CLLPDSVCDGFANCADGSDETN----------CSAKF 298
               P +G      F     I    +   + DG       ++  N          C A+ 
Sbjct: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE- 198

Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
             CGG + G  G  S+PS+  +Y +   CTW I    G +I L F +F +E     K+DY
Sbjct: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 254

Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
           +E+ E S      L     G   PP ++S+ + L + F TD      GFSA Y   +   
Sbjct: 255 LEI-EGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 309

Query: 419 NPCGPSEL 426
           +     EL
Sbjct: 310 HTTSTGEL 317



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 42/305 (13%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           C    + P G   SP+YP+ Y  N +C+W I       I L      +ES     FD L 
Sbjct: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLA 736

Query: 204 L--SPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
           +     PE P+L        P+  T+ SH+L + F +D S+ G GF+  Y     G   C
Sbjct: 737 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF--GHNEC 794

Query: 261 AH-----------DEFRCDQLICLLPDSVCDGFANCADGSDETNC-----SAKFSG---- 300
                        D F+    I ++ +   +GF     G++   C        +SG    
Sbjct: 795 PDPGIPINARRFGDNFQLGSSISVICE---EGFIK-TQGTETITCILMDGKVMWSGLIPK 850

Query: 301 ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
               CGG+ +   G   +P +   Y   L C W I    GHSI++ F  F    Q E  +
Sbjct: 851 CGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNY 906

Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
           D +EV++   +    LLG + G + P  L SS + + +LF TD+  S+ GF   Y +   
Sbjct: 907 DVLEVHD-GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 965

Query: 417 TENPC 421
               C
Sbjct: 966 NTYSC 970



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 90/310 (29%), Positives = 134/310 (43%), Gaps = 41/310 (13%)

Query: 138  PSPQ---STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESV 194
            PSP    + CGG L+G  GF  SPN+P PYP +  C W I V  D+ I L   + SIE  
Sbjct: 1539 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1598

Query: 195  ASCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA- 252
               L+  +   P+   PL+        P  + ++++ + + F SD SV   GFH  Y+A 
Sbjct: 1599 YDFLY--IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656

Query: 253  -----MAPG---RGSCAHDEFRCDQLICLLPDS--VCDGFA--NCADGSDE--------T 292
                   PG    G+    +++    +    D+  V  G++   C  G D          
Sbjct: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716

Query: 293  NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQD 352
            +C A    CG   TG +GT  +P+Y + Y     C + I+VP    +  QF  F      
Sbjct: 1717 SCHAP---CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH- 1772

Query: 353  ECKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
                D VEVY+     SS   SL G   G   P   +SS +++ + F +   I++ GF  
Sbjct: 1773 ----DVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHF 1825

Query: 410  TYLAFNATEN 419
             Y A   T +
Sbjct: 1826 VYQAVPRTSS 1835



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 90/334 (26%), Positives = 138/334 (41%), Gaps = 43/334 (12%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P  ++ CGG ++   G   SP YPD YP    C W ++V   + I +    L  E +   
Sbjct: 2237 PRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD- 2295

Query: 198  LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
             F  +   P+   P + +  G     ++ + ++ +L+ F SD +  GF    +HA+    
Sbjct: 2296 -FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV 2354

Query: 251  -QAMAPGRGS---CAHDEFRCDQLICL--LPDSVCDGFA--NCA-------DGSDETNCS 295
             Q   P   +      DEF    +I    LP     G A   C        DG+    C 
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV-CQ 2413

Query: 296  AKFSGCGGNLTGLQ--GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
                 C  N   L   G   +P Y   YP+  +C W ISV  G++I +    F    Q E
Sbjct: 2414 VL---CPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF----QTE 2466

Query: 354  CKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
             +FD ++VY+     S    SL G +  A    ++ S+ HE+ + +  DHG +  GF   
Sbjct: 2467 KEFDVLQVYDGPNIQSPVLISLSGDYSSAF---NITSNGHEVFLQWSADHGNNKKGFRIR 2523

Query: 411  YLAFNATENPCGP-SELSCQAGGCKG--VQWMCD 441
            Y+AF  +     P   +  Q GG     V+W CD
Sbjct: 2524 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACD 2557



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 74/300 (24%), Positives = 115/300 (38%), Gaps = 34/300 (11%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P+  + CGG + GP G   SP YP+ YP + +C W + V     +Q       +E     
Sbjct: 1021 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1080

Query: 198  LFDRLELSPEPEGPLLRVCGRVPPPTLNTNA---SHLLVVFVSDSSVEGFGFHAWYQAM- 253
            L   +  +     PL R+ G   PPT+N          + F+SD S+   GF+  +    
Sbjct: 1081 LL--ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138

Query: 254  --------APGRGSCAHDEFRCDQLICLLPDS----------VCDGFANCADGSDETNCS 295
                     P  GS     F     +     S          +C G       +    C 
Sbjct: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198

Query: 296  AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
            A+   CG + T  +G   +P+Y   Y +   C + I V AG  I +    F L      +
Sbjct: 1199 AE---CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1250

Query: 356  FDYVEVYETSSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
             D +++Y+        LLG F GA      L S+ ++L + F +D   +  GF   Y +F
Sbjct: 1251 GDVLKIYD-GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF 1309



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 39/136 (28%), Positives = 62/136 (45%), Gaps = 7/136 (5%)

Query: 290 DETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE 349
           D    S     CGG L GL GT  +P +   YP+   CTW I     + I++ F +F+LE
Sbjct: 14  DRQTASGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALE 73

Query: 350 AQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
            +    +DY+ +Y+       +   R  G   PP + S+    ++   +D  +S+ GF  
Sbjct: 74  EE----YDYLSLYD-GHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV 128

Query: 410 TY--LAFNATENPCGP 423
            Y  L  ++  NP  P
Sbjct: 129 YYEELQSSSCGNPGVP 144



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 40/306 (13%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
            P   + CG   +   G   SPNYP  Y  N  C++ IQV     I +      + +    
Sbjct: 1195 PRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVL 1254

Query: 197  CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA-- 254
             ++D  + +    G       R    TL++ ++ L + F SD+     GF   Y +    
Sbjct: 1255 KIYDGKDKTTHLLGAFTGASMR--GLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELS 1312

Query: 255  -------PGRGSCAHDE---------FRCDQLICLLPDSVCDGFANCADGSDET------ 292
                   P  G    D+         + C+    L   S+      C  G          
Sbjct: 1313 HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLL----KCMTGERRAWDYPLP 1368

Query: 293  NCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQ 351
            +C A+   CGG   G   G   +P Y   Y + L C W I V  G+ + LQF  F  EA 
Sbjct: 1369 SCIAE---CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA- 1424

Query: 352  DECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                 D + V++        LL    G+  P  + S+ + + + F TD  IS  GF+  +
Sbjct: 1425 ---SHDILRVWDGPPENDM-LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480

Query: 412  LAFNAT 417
             +  AT
Sbjct: 1481 SSSVAT 1486



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 5/111 (4%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           +  CGG + G  G  SSP++P+ Y  N  C W I       I L      +E      +D
Sbjct: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 253

Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
            LE+    E P + + G   PP + +N + L + FV+DS+    GF A YQ
Sbjct: 254 YLEIEGS-EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 8/152 (5%)

Query: 264 EFRCDQLICL--LPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQY 321
           +F CD+   L       C   A       +     K   CG NL G  GTF++P++  QY
Sbjct: 469 QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQY 528

Query: 322 PHQLLCTWHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGA 379
                C W I +V     I++ F  F L    E  +D + + +    G   ++L    G+
Sbjct: 529 DSNAQCVWVITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGS 584

Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
             P  +VS   ++ +  +TD  + S GF   Y
Sbjct: 585 FVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 616



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 8/86 (9%)

Query: 132  QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
            Q  G  P  Q  C    L     G   SP YPD YP    C W I V   + I + +E  
Sbjct: 2404 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2463

Query: 190  SIESVASCLFDRLEL--SPEPEGPLL 213
              E      FD L++   P  + P+L
Sbjct: 2464 QTEKE----FDVLQVYDGPNIQSPVL 2485


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score =  125 bits (313), Expect = 1e-28
 Identities = 93/302 (30%), Positives = 133/302 (44%), Gaps = 40/302 (13%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            CGG+L+  +G   SP YP+PY  N +CVW I V     IQ+++ + + E     L D  +
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSL-DFYD 1893

Query: 204  LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
                    L    G   P  LN+ +++L + F SD SV   GFH  Y A+  G  SC   
Sbjct: 1894 GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI--GLDSCPEP 1951

Query: 264  E-------------------FRCDQLICLLPDSVCDGFANCADGSDET------NCSAKF 298
            +                   F+CDQ   L   S       C  G           C A+ 
Sbjct: 1952 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS----HITCMPGPVRRWNYPIPICLAQ- 2006

Query: 299  SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
              CGG ++   G   +P +   YP  L CTW I++P G  + LQF NFS E       DY
Sbjct: 2007 --CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2060

Query: 359  VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
            +EV  + SS   +++GR  G + P  L S+ HE ++ F +D+  +  GF   Y A+    
Sbjct: 2061 LEV-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2119

Query: 419  NP 420
             P
Sbjct: 2120 CP 2121



 Score =  117 bits (293), Expect = 3e-26
 Identities = 95/306 (31%), Positives = 131/306 (42%), Gaps = 45/306 (14%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHI-QVATDHAIQLKIEALSIESVASCLFDR 201
           TCG  L GP G F+SPN+P  Y  N  CVW I  V T+  IQ+  E   +E      +D 
Sbjct: 443 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 498

Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
           L +       +P   L  + G   P  + + +S + +   +D SV   GF   Y+ +   
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE-- 556

Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFAN-------CADGSD---------------ETNC 294
           + SC       D    L      DGF+N       C  G +                 N 
Sbjct: 557 KESCG------DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANI 610

Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
                 C  N T   GT  +P Y + Y + L C W I    G  I L F++F LE+Q   
Sbjct: 611 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ--- 667

Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
            FD++ V +  S  +  +LG F GAE P HL S+ H L + F+ DH +S  GF+ TY  F
Sbjct: 668 -FDFLAVKDGDSPES-PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF 725

Query: 415 NATENP 420
              E P
Sbjct: 726 GHNECP 731



 Score =  108 bits (271), Expect = 1e-23
 Identities = 98/349 (28%), Positives = 147/349 (42%), Gaps = 45/349 (12%)

Query: 99   GASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSP 158
            G+S S +   G   T  T TIT     G       SG+ P   + CGG  S P G   SP
Sbjct: 749  GSSISVICEEGFIKTQGTETITCILMDGKVMW---SGLIPKCGAPCGGHFSAPSGVILSP 805

Query: 159  NYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPE--GPLL-RV 215
             +P  Y  + +C W I+    H+I++  E    E      +D LE+   P    PLL   
Sbjct: 806  GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSY 861

Query: 216  CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC------------AHD 263
             G   P  L ++++ + ++F +D+S    GF   Y+++     SC             HD
Sbjct: 862  NGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD 921

Query: 264  -------EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
                    F CD    L  +       N         C A    CGG++ G  GT  +P 
Sbjct: 922  FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL---CGGDVRGPSGTILSPG 978

Query: 317  YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL-LGR 375
            Y + YP+ L CTW + V  G  ++  FH F LE       DY+ + E   +G+F+  L R
Sbjct: 979  YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITE---NGSFTQPLAR 1031

Query: 376  FCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYLAFNATENPC 421
              G++ PP +   +  +    + F +D  IS  GF+ T+  +N    PC
Sbjct: 1032 LTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNL--EPC 1078



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 82/293 (27%), Positives = 121/293 (41%), Gaps = 38/293 (12%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
           TCGG L G  G   SP +P  YP   +C W I     + IQ+  ++ ++E      +D L
Sbjct: 64  TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 119

Query: 203 EL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM------ 253
            L    P P     R+ G   PP + +  S   +   SD +V   GF  +Y+ +      
Sbjct: 120 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179

Query: 254 ---APGRGSCAHDEFRCDQLI--CLLPDSVCDGFANCADGSDETN----------CSAKF 298
               P +G      F     I    +   + DG       ++  N          C A+ 
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE- 238

Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
             CGG + G  G  S+PS+  +Y +   CTW I    G +I L F +F +E     K+DY
Sbjct: 239 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 294

Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
           +E+ E S      L     G   PP ++S+ + L + F TD      GFSA Y
Sbjct: 295 LEI-EGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 42/305 (13%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           C    + P G   SP+YP+ Y  N +C+W I       I L      +ES     FD L 
Sbjct: 617 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLA 672

Query: 204 L--SPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
           +     PE P+L        P+  T+ SH+L + F +D S+ G GF+  Y     G   C
Sbjct: 673 VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF--GHNEC 730

Query: 261 AH-----------DEFRCDQLICLLPDSVCDGFANCADGSDETNC-----SAKFSG---- 300
                        D F+    I ++ +   +GF     G++   C        +SG    
Sbjct: 731 PDPGIPINARRFGDNFQLGSSISVICE---EGFIK-TQGTETITCILMDGKVMWSGLIPK 786

Query: 301 ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
               CGG+ +   G   +P +   Y   L C W I    GHSI++ F  F    Q E  +
Sbjct: 787 CGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNY 842

Query: 357 DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
           D +EV++   +    LLG + G + P  L SS + + +LF TD+  S+ GF   Y +   
Sbjct: 843 DVLEVHD-GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 901

Query: 417 TENPC 421
               C
Sbjct: 902 NTYSC 906



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 90/310 (29%), Positives = 134/310 (43%), Gaps = 41/310 (13%)

Query: 138  PSPQ---STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESV 194
            PSP    + CGG L+G  GF  SPN+P PYP +  C W I V  D+ I L   + SIE  
Sbjct: 1475 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1534

Query: 195  ASCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA- 252
               L+  +   P+   PL+        P  + ++++ + + F SD SV   GFH  Y+A 
Sbjct: 1535 YDFLY--IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1592

Query: 253  -----MAPG---RGSCAHDEFRCDQLICLLPDS--VCDGFA--NCADGSDE--------T 292
                   PG    G+    +++    +    D+  V  G++   C  G D          
Sbjct: 1593 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652

Query: 293  NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQD 352
            +C A    CG   TG +GT  +P+Y + Y     C + I+VP    +  QF  F      
Sbjct: 1653 SCHAP---CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH- 1708

Query: 353  ECKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
                D VEVY+     SS   SL G   G   P   +SS +++ + F +   I++ GF  
Sbjct: 1709 ----DVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHF 1761

Query: 410  TYLAFNATEN 419
             Y A   T +
Sbjct: 1762 VYQAVPRTSS 1771



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 90/334 (26%), Positives = 138/334 (41%), Gaps = 43/334 (12%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P  ++ CGG ++   G   SP YPD YP    C W ++V   + I +    L  E +   
Sbjct: 2173 PRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD- 2231

Query: 198  LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
             F  +   P+   P + +  G     ++ + ++ +L+ F SD +  GF    +HA+    
Sbjct: 2232 -FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV 2290

Query: 251  -QAMAPGRGS---CAHDEFRCDQLICL--LPDSVCDGFA--NCA-------DGSDETNCS 295
             Q   P   +      DEF    +I    LP     G A   C        DG+    C 
Sbjct: 2291 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV-CQ 2349

Query: 296  AKFSGCGGNLTGLQ--GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
                 C  N   L   G   +P Y   YP+  +C W ISV  G++I +    F    Q E
Sbjct: 2350 VL---CPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF----QTE 2402

Query: 354  CKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
             +FD ++VY+     S    SL G +  A    ++ S+ HE+ + +  DHG +  GF   
Sbjct: 2403 KEFDVLQVYDGPNIQSPVLISLSGDYSSAF---NITSNGHEVFLQWSADHGNNKKGFRIR 2459

Query: 411  YLAFNATENPCGP-SELSCQAGGCKG--VQWMCD 441
            Y+AF  +     P   +  Q GG     V+W CD
Sbjct: 2460 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACD 2493



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 78/324 (24%), Positives = 121/324 (37%), Gaps = 62/324 (19%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           +  CGG + G  G  SSP++P+ Y  N  C W I       I L      +E      +D
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293

Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA-------- 252
            LE+    E P + + G   PP + +N + L + FV+DS+    GF A YQ         
Sbjct: 294 YLEIEGS-EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKS 352

Query: 253 ----MAPGRGSC-------------------------------------AHDEFRCDQLI 271
               + PG+ +                                      +  +F CD+  
Sbjct: 353 RGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDY 412

Query: 272 CL--LPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTW 329
            L       C   A       +     K   CG NL G  GTF++P++  QY     C W
Sbjct: 413 VLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVW 472

Query: 330 HI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGAEPPPHLVS 387
            I +V     I++ F  F L    E  +D + + +    G   ++L    G+  P  +VS
Sbjct: 473 VITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVS 528

Query: 388 SHHELAVLFRTDHGISSGGFSATY 411
              ++ +  +TD  + S GF   Y
Sbjct: 529 MSSQMWLHLQTDESVGSVGFKVNY 552



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 74/300 (24%), Positives = 115/300 (38%), Gaps = 34/300 (11%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P+  + CGG + GP G   SP YP+ YP + +C W + V     +Q       +E     
Sbjct: 957  PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1016

Query: 198  LFDRLELSPEPEGPLLRVCGRVPPPTLNTNA---SHLLVVFVSDSSVEGFGFHAWYQAM- 253
            L   +  +     PL R+ G   PPT+N          + F+SD S+   GF+  +    
Sbjct: 1017 LL--ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1074

Query: 254  --------APGRGSCAHDEFRCDQLICLLPDS----------VCDGFANCADGSDETNCS 295
                     P  GS     F     +     S          +C G       +    C 
Sbjct: 1075 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134

Query: 296  AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
            A+   CG + T  +G   +P+Y   Y +   C + I V AG  I +    F L      +
Sbjct: 1135 AE---CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1186

Query: 356  FDYVEVYETSSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
             D +++Y+        LLG F GA      L S+ ++L + F +D   +  GF   Y +F
Sbjct: 1187 GDVLKIYD-GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF 1245



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 40/306 (13%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
            P   + CG   +   G   SPNYP  Y  N  C++ IQV     I +      + +    
Sbjct: 1131 PRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVL 1190

Query: 197  CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA-- 254
             ++D  + +    G       R    TL++ ++ L + F SD+     GF   Y +    
Sbjct: 1191 KIYDGKDKTTHLLGAFTGASMR--GLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELS 1248

Query: 255  -------PGRGSCAHDE---------FRCDQLICLLPDSVCDGFANCADGSDET------ 292
                   P  G    D+         + C+    L   S+      C  G          
Sbjct: 1249 HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLL----KCMTGERRAWDYPLP 1304

Query: 293  NCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQ 351
            +C A+   CGG   G   G   +P Y   Y + L C W I V  G+ + LQF  F  EA 
Sbjct: 1305 SCIAE---CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA- 1360

Query: 352  DECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                 D + V++        LL    G+  P  + S+ + + + F TD  IS  GF+  +
Sbjct: 1361 ---SHDILRVWDGPPENDM-LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1416

Query: 412  LAFNAT 417
             +  AT
Sbjct: 1417 SSSVAT 1422



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 7/125 (5%)

Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
           CGG L GL GT  +P +   YP+   CTW I     + I++ F +F+LE +    +DY+ 
Sbjct: 65  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120

Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY--LAFNATE 418
           +Y+       +   R  G   PP + S+    ++   +D  +S+ GF   Y  L  ++  
Sbjct: 121 LYD-GHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179

Query: 419 NPCGP 423
           NP  P
Sbjct: 180 NPGVP 184



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 8/86 (9%)

Query: 132  QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
            Q  G  P  Q  C    L     G   SP YPD YP    C W I V   + I + +E  
Sbjct: 2340 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2399

Query: 190  SIESVASCLFDRLEL--SPEPEGPLL 213
              E      FD L++   P  + P+L
Sbjct: 2400 QTEKE----FDVLQVYDGPNIQSPVL 2421


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  125 bits (313), Expect = 1e-28
 Identities = 93/302 (30%), Positives = 133/302 (44%), Gaps = 40/302 (13%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            CGG+L+  +G   SP YP+PY  N +CVW I V     IQ+++ + + E     L D  +
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSL-DFYD 1997

Query: 204  LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
                    L    G   P  LN+ +++L + F SD SV   GFH  Y A+  G  SC   
Sbjct: 1998 GGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI--GLDSCPEP 2055

Query: 264  E-------------------FRCDQLICLLPDSVCDGFANCADGSDET------NCSAKF 298
            +                   F+CDQ   L   S       C  G           C A+ 
Sbjct: 2056 QTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHS----HITCMPGPVRRWNYPIPICLAQ- 2110

Query: 299  SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
              CGG ++   G   +P +   YP  L CTW I++P G  + LQF NFS E       DY
Sbjct: 2111 --CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2164

Query: 359  VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
            +EV  + SS   +++GR  G + P  L S+ HE ++ F +D+  +  GF   Y A+    
Sbjct: 2165 LEV-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2223

Query: 419  NP 420
             P
Sbjct: 2224 CP 2225



 Score =  117 bits (293), Expect = 3e-26
 Identities = 95/306 (31%), Positives = 131/306 (42%), Gaps = 45/306 (14%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHI-QVATDHAIQLKIEALSIESVASCLFDR 201
           TCG  L GP G F+SPN+P  Y  N  CVW I  V T+  IQ+  E   +E      +D 
Sbjct: 547 TCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 602

Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
           L +       +P   L  + G   P  + + +S + +   +D SV   GF   Y+ +   
Sbjct: 603 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE-- 660

Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFAN-------CADGSD---------------ETNC 294
           + SC       D    L      DGF+N       C  G +                 N 
Sbjct: 661 KESCG------DPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANI 714

Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
                 C  N T   GT  +P Y + Y + L C W I    G  I L F++F LE+Q   
Sbjct: 715 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ--- 771

Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
            FD++ V +  S  +  +LG F GAE P HL S+ H L + F+ DH +S  GF+ TY  F
Sbjct: 772 -FDFLAVKDGDSPES-PILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF 829

Query: 415 NATENP 420
              E P
Sbjct: 830 GHNECP 835



 Score =  108 bits (271), Expect = 1e-23
 Identities = 98/349 (28%), Positives = 147/349 (42%), Gaps = 45/349 (12%)

Query: 99   GASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSP 158
            G+S S +   G   T  T TIT     G       SG+ P   + CGG  S P G   SP
Sbjct: 853  GSSISVICEEGFIKTQGTETITCILMDGKVMW---SGLIPKCGAPCGGHFSAPSGVILSP 909

Query: 159  NYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPE--GPLL-RV 215
             +P  Y  + +C W I+    H+I++  E    E      +D LE+   P    PLL   
Sbjct: 910  GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSY 965

Query: 216  CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC------------AHD 263
             G   P  L ++++ + ++F +D+S    GF   Y+++     SC             HD
Sbjct: 966  NGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHD 1025

Query: 264  -------EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
                    F CD    L  +       N         C A    CGG++ G  GT  +P 
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL---CGGDVRGPSGTILSPG 1082

Query: 317  YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL-LGR 375
            Y + YP+ L CTW + V  G  ++  FH F LE       DY+ + E   +G+F+  L R
Sbjct: 1083 YPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLITE---NGSFTQPLAR 1135

Query: 376  FCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYLAFNATENPC 421
              G++ PP +   +  +    + F +D  IS  GF+ T+  +N    PC
Sbjct: 1136 LTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNL--EPC 1182



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 84/308 (27%), Positives = 125/308 (40%), Gaps = 38/308 (12%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
           TCGG L G  G   SP +P  YP   +C W I     + IQ+  ++ ++E      +D L
Sbjct: 64  TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYL 119

Query: 203 EL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM------ 253
            L    P P     R+ G   PP + +  S   +   SD +V   GF  +Y+ +      
Sbjct: 120 SLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179

Query: 254 ---APGRGSCAHDEFRCDQLI--CLLPDSVCDGFANCADGSDETN----------CSAKF 298
               P +G      F     I    +   + DG       ++  N          C A+ 
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE- 238

Query: 299 SGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY 358
             CGG + G  G  S+PS+  +Y +   CTW I    G +I L F +F +E     K+DY
Sbjct: 239 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDY 294

Query: 359 VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
           +E+ E S      L     G   PP ++S+ + L + F TD      GFSA Y   +   
Sbjct: 295 LEI-EGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLT 349

Query: 419 NPCGPSEL 426
           +     EL
Sbjct: 350 HTTSTGEL 357



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 42/305 (13%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            C    + P G   SP+YP+ Y  N +C+W I       I L      +ES     FD L 
Sbjct: 721  CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLA 776

Query: 204  L--SPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
            +     PE P+L        P+  T+ SH+L + F +D S+ G GF+  Y     G   C
Sbjct: 777  VKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTF--GHNEC 834

Query: 261  AH-----------DEFRCDQLICLLPDSVCDGFANCADGSDETNC-----SAKFSG---- 300
                         D F+    I ++ +   +GF     G++   C        +SG    
Sbjct: 835  PDPGIPINARRFGDNFQLGSSISVICE---EGFIK-TQGTETITCILMDGKVMWSGLIPK 890

Query: 301  ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
                CGG+ +   G   +P +   Y   L C W I    GHSI++ F  F    Q E  +
Sbjct: 891  CGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF----QTELNY 946

Query: 357  DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
            D +EV++   +    LLG + G + P  L SS + + +LF TD+  S+ GF   Y +   
Sbjct: 947  DVLEVHD-GPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTV 1005

Query: 417  TENPC 421
                C
Sbjct: 1006 NTYSC 1010



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 90/310 (29%), Positives = 134/310 (43%), Gaps = 41/310 (13%)

Query: 138  PSPQ---STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESV 194
            PSP    + CGG L+G  GF  SPN+P PYP +  C W I V  D+ I L   + SIE  
Sbjct: 1579 PSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN 1638

Query: 195  ASCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA- 252
               L+  +   P+   PL+        P  + ++++ + + F SD SV   GFH  Y+A 
Sbjct: 1639 YDFLY--IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1696

Query: 253  -----MAPG---RGSCAHDEFRCDQLICLLPDS--VCDGFA--NCADGSDE--------T 292
                   PG    G+    +++    +    D+  V  G++   C  G D          
Sbjct: 1697 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756

Query: 293  NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQD 352
            +C A    CG   TG +GT  +P+Y + Y     C + I+VP    +  QF  F      
Sbjct: 1757 SCHAP---CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLH- 1812

Query: 353  ECKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSA 409
                D VEVY+     SS   SL G   G   P   +SS +++ + F +   I++ GF  
Sbjct: 1813 ----DVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHF 1865

Query: 410  TYLAFNATEN 419
             Y A   T +
Sbjct: 1866 VYQAVPRTSS 1875



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 90/334 (26%), Positives = 138/334 (41%), Gaps = 43/334 (12%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P  ++ CGG ++   G   SP YPD YP    C W ++V   + I +    L  E +   
Sbjct: 2277 PRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYD- 2335

Query: 198  LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
             F  +   P+   P + +  G     ++ + ++ +L+ F SD +  GF    +HA+    
Sbjct: 2336 -FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRV 2394

Query: 251  -QAMAPGRGS---CAHDEFRCDQLICL--LPDSVCDGFA--NCA-------DGSDETNCS 295
             Q   P   +      DEF    +I    LP     G A   C        DG+    C 
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV-CQ 2453

Query: 296  AKFSGCGGNLTGLQ--GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
                 C  N   L   G   +P Y   YP+  +C W ISV  G++I +    F    Q E
Sbjct: 2454 VL---CPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF----QTE 2506

Query: 354  CKFDYVEVYE---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
             +FD ++VY+     S    SL G +  A    ++ S+ HE+ + +  DHG +  GF   
Sbjct: 2507 KEFDVLQVYDGPNIQSPVLISLSGDYSSAF---NITSNGHEVFLQWSADHGNNKKGFRIR 2563

Query: 411  YLAFNATENPCGP-SELSCQAGGCKG--VQWMCD 441
            Y+AF  +     P   +  Q GG     V+W CD
Sbjct: 2564 YIAFYCSTPESPPHGYIISQTGGQLNSVVRWACD 2597



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 74/300 (24%), Positives = 115/300 (38%), Gaps = 34/300 (11%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P+  + CGG + GP G   SP YP+ YP + +C W + V     +Q       +E     
Sbjct: 1061 PTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDY 1120

Query: 198  LFDRLELSPEPEGPLLRVCGRVPPPTLNTNA---SHLLVVFVSDSSVEGFGFHAWYQAM- 253
            L   +  +     PL R+ G   PPT+N          + F+SD S+   GF+  +    
Sbjct: 1121 LL--ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1178

Query: 254  --------APGRGSCAHDEFRCDQLICLLPDS----------VCDGFANCADGSDETNCS 295
                     P  GS     F     +     S          +C G       +    C 
Sbjct: 1179 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238

Query: 296  AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
            A+   CG + T  +G   +P+Y   Y +   C + I V AG  I +    F L      +
Sbjct: 1239 AE---CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQ 1290

Query: 356  FDYVEVYETSSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
             D +++Y+        LLG F GA      L S+ ++L + F +D   +  GF   Y +F
Sbjct: 1291 GDVLKIYD-GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSF 1349



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 40/306 (13%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
            P   + CG   +   G   SPNYP  Y  N  C++ IQV     I +      + +    
Sbjct: 1235 PRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVL 1294

Query: 197  CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA-- 254
             ++D  + +    G       R    TL++ ++ L + F SD+     GF   Y +    
Sbjct: 1295 KIYDGKDKTTHLLGAFTGASMR--GLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELS 1352

Query: 255  -------PGRGSCAHDE---------FRCDQLICLLPDSVCDGFANCADGSDET------ 292
                   P  G    D+         + C+    L   S+      C  G          
Sbjct: 1353 HCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLL----KCMTGERRAWDYPLP 1408

Query: 293  NCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQ 351
            +C A+   CGG   G   G   +P Y   Y + L C W I V  G+ + LQF  F  EA 
Sbjct: 1409 SCIAE---CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA- 1464

Query: 352  DECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                 D + V++        LL    G+  P  + S+ + + + F TD  IS  GF+  +
Sbjct: 1465 ---SHDILRVWDGPPENDM-LLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1520

Query: 412  LAFNAT 417
             +  AT
Sbjct: 1521 SSSVAT 1526



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 5/111 (4%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           +  CGG + G  G  SSP++P+ Y  N  C W I       I L      +E      +D
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293

Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
            LE+    E P + + G   PP + +N + L + FV+DS+    GF A YQ
Sbjct: 294 YLEIEGS-EPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 40/152 (26%), Positives = 63/152 (41%), Gaps = 8/152 (5%)

Query: 264 EFRCDQLICL--LPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQY 321
           +F CD+   L       C   A       +     K   CG NL G  GTF++P++  QY
Sbjct: 509 QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQY 568

Query: 322 PHQLLCTWHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGA 379
                C W I +V     I++ F  F L    E  +D + + +    G   ++L    G+
Sbjct: 569 DSNAQCVWVITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGS 624

Query: 380 EPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
             P  +VS   ++ +  +TD  + S GF   Y
Sbjct: 625 FVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 656



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 27/86 (31%), Positives = 34/86 (39%), Gaps = 8/86 (9%)

Query: 132  QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
            Q  G  P  Q  C    L     G   SP YPD YP    C W I V   + I + +E  
Sbjct: 2444 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2503

Query: 190  SIESVASCLFDRLEL--SPEPEGPLL 213
              E      FD L++   P  + P+L
Sbjct: 2504 QTEKE----FDVLQVYDGPNIQSPVL 2525


>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
          Length = 3487

 Score =  123 bits (309), Expect = 4e-28
 Identities = 88/301 (29%), Positives = 137/301 (45%), Gaps = 42/301 (13%)

Query: 137  SPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVAS 196
            +P+    CGG L+  RG   SP +P+PY  + +CVW I V     IQ+++    +  V  
Sbjct: 1789 APTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQV----VSFVTE 1844

Query: 197  CLFDRLELSPEPEGPLLRV---CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM 253
              +D LE+    +  +  +    G   P  LN+ ++ L + F SD SV   GFH  Y+ +
Sbjct: 1845 QNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904

Query: 254  A---------PGRGSCAHDEFRCDQLICLL--PDSVCDGFAN--CADGS------DETNC 294
                      P  G    + +  + ++     P     G A+  C  G+          C
Sbjct: 1905 GLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964

Query: 295  SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
             A+   CGG +  ++G   +P +   YP  + C+W I++P G    +QF NFS E     
Sbjct: 1965 IAQ---CGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEP---- 2017

Query: 355  KFDYVEV----YETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSAT 410
              DY+E+    YETS      ++GRF G+E P  L+S+ HE  V F +DH  +  GF   
Sbjct: 2018 NHDYIEIRNGPYETS-----RMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLE 2072

Query: 411  Y 411
            Y
Sbjct: 2073 Y 2073



 Score =  110 bits (274), Expect = 5e-24
 Identities = 95/309 (30%), Positives = 134/309 (43%), Gaps = 40/309 (12%)

Query: 128 PKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIE 187
           P+ Q +S    S    C   L GP G   SP +P  YP   +C W I     H IQL  +
Sbjct: 10  PRWQVQSHHPRSAGQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQ 69

Query: 188 ALSIESVASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
           + ++E      FD L +    P+PE    R+ G   P T+ + A+ L +  +SD +V   
Sbjct: 70  SFALEED----FDVLSVFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQ 125

Query: 245 GFHAWYQAMA------PGR---GSCAHDEFRCDQLI---CLLPDSVCDGFA--NCADGSD 290
           GFHA Y+ +       PGR   G      F     +   C L     +G A   C  GS+
Sbjct: 126 GFHATYEVLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNL-GFFLEGHAVLTCHAGSE 184

Query: 291 ET--------NCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQ 342
            +        +C A    CGG L G  G  S+P +  +Y +   CTW I    G +I L 
Sbjct: 185 NSATWDFPLPSCRAD-DACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALV 243

Query: 343 FHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGI 402
           F +F LE      +D++EV  T  S  +     F GA  P  ++SS + L + F +D   
Sbjct: 244 FIDFQLED----GYDFLEVTGTEGSSLW-----FTGASLPAPVISSKNWLRLHFTSDGNH 294

Query: 403 SSGGFSATY 411
              GFSA Y
Sbjct: 295 RQRGFSAQY 303



 Score =  102 bits (253), Expect = 1e-21
 Identities = 86/307 (28%), Positives = 131/307 (42%), Gaps = 41/307 (13%)

Query: 138  PSPQSTCGGLLSGP-RGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVAS 196
            P+  + CGG + G   G   SP YP PY  N +C+W I+      I L       E V  
Sbjct: 1265 PTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHD 1324

Query: 197  CLFDRLELSPEPEGPLLR-VCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA- 254
             L  R+   P   G LL+ + G   P  L++  + +++ F +D      GF   +     
Sbjct: 1325 VL--RIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTA 1382

Query: 255  --------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC------------ 294
                    P  GS + D +          D    G+A    GS E +C            
Sbjct: 1383 TSCNDPGIPQNGSRSGDSWEAGDSTVFQCDP---GYA--LQGSAEISCVKIENRFFWQPS 1437

Query: 295  -SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE 353
                 + CGG+LTG  G   +P+Y + YP    C W ++V   + I L F+ F+LE    
Sbjct: 1438 PPTCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEP--- 1494

Query: 354  CKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
              +D++ +Y+   S    L+G F G++ P  + SS + L + FR+D  +S+ GF   Y  
Sbjct: 1495 -GYDFLHIYDGRDS-LSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY-- 1550

Query: 414  FNATENP 420
               TENP
Sbjct: 1551 ---TENP 1554



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 78/296 (26%), Positives = 118/296 (39%), Gaps = 27/296 (9%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIESVASCLFDRL 202
           C   L GP G  +SPN+P  Y  N HCVW I        I+L  E   +E     L    
Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGD 464

Query: 203 ELSPEPEGPLLRVCGRVPPPTLNTNASH-LLVVFVSDSSVEGFGFHAWYQAMAPG----- 256
                 +  +L +      P L  + +H + ++F +D S    GF A Y+ +  G     
Sbjct: 465 GGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDP 524

Query: 257 --------RGSCAHD----EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGN 304
                    GS  H     +F C     L+         N    + +  C      C  N
Sbjct: 525 GIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC---VFSCFFN 581

Query: 305 LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYET 364
            T   G   +P+Y + Y + L C W I       I L F++  +E Q    FD++ + + 
Sbjct: 582 FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQ----FDFLVIKDG 637

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
           +++ A  +LG F G + P  + SS H   + F+TDH     GF+ T+  F   E P
Sbjct: 638 ATAEA-PVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECP 692



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 83/316 (26%), Positives = 123/316 (38%), Gaps = 34/316 (10%)

Query: 129 KGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEA 188
           K  Q S   P    +C    + P G   SPNYP+ Y  + HCVW I    +  I L    
Sbjct: 563 KNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFND 622

Query: 189 LSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFH 247
           + +E     L   ++     E P+L        P+  T++ H+  + F +D S    GF+
Sbjct: 623 IDVEPQFDFLV--IKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFN 680

Query: 248 AWYQAM---------APGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKF 298
             +             P  G    D  +    I  L D   +GF     GS+   C  K 
Sbjct: 681 ITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCD---EGFLG-TQGSETITCVLKE 736

Query: 299 SG-------------CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHN 345
                          CGG+LT   GT  +P +   Y   L C W I    G+ I++ F  
Sbjct: 737 GSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDR 796

Query: 346 FSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSG 405
           F    + E  +D +EV +  +  A  L+G + G + P  L+S+ + L +LF TD   S  
Sbjct: 797 F----KTEVNYDTLEVRDGRTYSA-PLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDI 851

Query: 406 GFSATYLAFNATENPC 421
           GF   Y       + C
Sbjct: 852 GFQLRYETITLQSDHC 867



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 79/314 (25%), Positives = 128/314 (40%), Gaps = 46/314 (14%)

Query: 141  QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
            ++ CGG L+ P G   SP +P  Y     C W I+    + I++  +    E      +D
Sbjct: 749  EAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VNYD 804

Query: 201  RLELSPEP--EGPLLRVC-GRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA--- 254
             LE+        PL+ V  G   P  L + +++L ++F +D S    GF   Y+ +    
Sbjct: 805  TLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQS 864

Query: 255  --------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG------ 300
                    P  G    ++F    L+       CD     +DG +   C   F        
Sbjct: 865  DHCLDPGIPVNGQRHGNDFYVGALVTFS----CDSGYTLSDG-EPLECEPNFQWSRALPS 919

Query: 301  ----CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKF 356
                CGG + G  GT  +P +   YP+ L CTW I    G  +   FH F LE+      
Sbjct: 920  CEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLES----GH 975

Query: 357  DYVEVYETSSSGAFSL-LGRFCGAEPPPHL---VSSHHELAVLFRTDHGISSGGFSATYL 412
            DY+ + E   +G+F+  L +  G+  P  +   +  +    V F +D  +S  GF+ T+ 
Sbjct: 976  DYLLITE---NGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFS 1032

Query: 413  AFNATENPCGPSEL 426
             ++    PC   E+
Sbjct: 1033 EYDL--EPCEEPEV 1044



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 88/329 (26%), Positives = 133/329 (40%), Gaps = 63/329 (19%)

Query: 137  SPSPQST--CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDH-----------AIQ 183
            +P P  T  CGG   G  G   SPNYP  Y     C++ + V  D+           A+ 
Sbjct: 1610 NPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN 1669

Query: 184  LKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEG 243
              +E     S  S L   L  S   E         +P  T N     +L+ F +      
Sbjct: 1670 DVVEVHDGHSQHSRLLSSLSGSHTGES--------LPLATSN----QVLIKFSAKGLAPA 1717

Query: 244  FGFHAWYQAMA------------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDE 291
             GFH  YQA+             P  G     +F    ++    +S   G+A    GS E
Sbjct: 1718 RGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNS---GYA--LQGSPE 1772

Query: 292  TNCS------AKFS--------GCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGH 337
              C       A+++         CGGNLT  +GT  +P + + Y + L C W I VP G 
Sbjct: 1773 IECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGA 1832

Query: 338  SIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFR 397
             I++Q  +F  E      +D +EV++  +    ++LG F G   P  L S+ ++L + F 
Sbjct: 1833 GIQIQVVSFVTEQN----WDSLEVFD-GADNTVTMLGSFSGTTVPALLNSTSNQLYLHFY 1887

Query: 398  TDHGISSGGFSATY--LAFNATENPCGPS 424
            +D  +S+ GF   Y  +  ++   P  PS
Sbjct: 1888 SDISVSAAGFHLEYKTVGLSSCPEPAVPS 1916



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 93/341 (27%), Positives = 133/341 (39%), Gaps = 53/341 (15%)

Query: 130  GQQESGVSPSPQ--STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIE 187
            G++    SP P+  + CG  ++G +G   SPN+P  Y  N  C++ IQ      IQLK  
Sbjct: 1082 GRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKAR 1141

Query: 188  ALSI-ESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGF 246
            A  + E     ++D    S    G        +   TLN+ +S L + F++D+     GF
Sbjct: 1142 AFELSEGDVLKVYDGNNNSARLLGVFSH--SEMMGVTLNSTSSSLWLDFITDAENTSKGF 1199

Query: 247  HAWYQAM---------APGRGSCAHDE---------FRCD---------QLICLLPDSVC 279
               + +           P  G   HDE         F CD         +L+CL      
Sbjct: 1200 ELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCL------ 1253

Query: 280  DGFANCADGSDETNCSAKFSGCGGNLTG-LQGTFSTPSYLQQYPHQLLCTWHISVPAGHS 338
             G     D    T C A+   CGG + G + G   +P Y   Y H L C W I   AG +
Sbjct: 1254 SGERRTWDRPLPT-CVAE---CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCT 1309

Query: 339  IELQFHNFSLEAQDECKFDYVEVYE-TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFR 397
            I L F  F  E       D + +++    SG   LL    G   P  L S+ + + + F 
Sbjct: 1310 IGLHFLVFDTEE----VHDVLRIWDGPVESGV--LLKELSGPALPKDLHSTFNSVVLQFS 1363

Query: 398  TDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQW 438
            TD   S  GF+  +    AT   C    +  Q G   G  W
Sbjct: 1364 TDFFTSKQGFAIQFSVSTATS--CNDPGIP-QNGSRSGDSW 1401



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 84/328 (25%), Positives = 125/328 (38%), Gaps = 76/328 (23%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CGG L G  G  SSP++P  Y  N  C W I       I L      +E      +D LE
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLE 257

Query: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM---------- 253
           ++   EG  L   G   P  + ++ + L + F SD +    GF A YQ            
Sbjct: 258 VTGT-EGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGV 316

Query: 254 -------------------------------APGRGSCAHDEFR--------CDQ----- 269
                                           P RG     +FR        C++     
Sbjct: 317 KLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQ 376

Query: 270 ----LICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQL 325
               + C+    V D FA  +D      C A+   C  +L G  G  ++P++  QY +  
Sbjct: 377 GSKRITCM---KVSDMFAAWSD--HRPVCRARM--CDAHLRGPSGIITSPNFPIQYDNNA 429

Query: 326 LCTWHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGAEPPP 383
            C W I ++     I+L F  F LE      +D + V +    G   ++L    G   P 
Sbjct: 430 HCVWIITALNPSKVIKLAFEEFDLER----GYDTLTVGDGGQDGDQKTVLYILTGTSVPD 485

Query: 384 HLVSSHHELAVLFRTDHGISSGGFSATY 411
            +VS++H++ +LF+TD   SS GF A+Y
Sbjct: 486 LIVSTNHQMWLLFQTDGSGSSLGFKASY 513



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 77/305 (25%), Positives = 121/305 (39%), Gaps = 44/305 (14%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P  +  CGG ++   G   SP +P PY  +  CVW I V   H ++L +  L  E     
Sbjct: 2176 PKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGD- 2234

Query: 198  LFDRLELSPEPEGPLLRVCGR-VPPPTLNTNASHLLVVFVSDSSVEG---FGFHAWYQAM 253
             F  +   P+   P L V  R +   T+ ++++ +L+ F  D++  G     F A+    
Sbjct: 2235 -FITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTK 2293

Query: 254  AP-------GRGSCAHDEFRCDQLI---CLLPDSVCDGFANCADGSDETNCS----AKFS 299
             P             ++EF    ++   CL       GF     G++   C      +F 
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCL------PGFT--LVGNEILTCKLGTYLQFE 2345

Query: 300  G--------CGGN--LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE 349
            G        C  N  LT   G   + SY   YP    C+W + V   ++I L    F  E
Sbjct: 2346 GPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSE 2405

Query: 350  AQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLV-SSHHELAVLFRTDHGISSGGFS 408
             Q    +D  E+++   SG   LL    G    P +V SS + + + + +DH  +  GF 
Sbjct: 2406 KQ----YDEFEIFD-GPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFK 2460

Query: 409  ATYLA 413
              Y A
Sbjct: 2461 IRYSA 2465



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 82/307 (26%), Positives = 128/307 (41%), Gaps = 36/307 (11%)

Query: 132  QESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI 191
            Q S   PS ++ CGG + G  G   SP +PD YP N +C W I+ +    +        +
Sbjct: 912  QWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHL 971

Query: 192  ESVASCLFDRLELSPEPEGPLLRVCG-RVPPPT---LNTNASHLLVVFVSDSSVEGFGFH 247
            ES    L   +  +     PL ++ G R+P P    L  N +   V F+SD S+   GF+
Sbjct: 972  ESGHDYLL--ITENGSFTQPLRQLTGSRLPAPISAGLYGNFT-AQVRFISDFSMSYEGFN 1028

Query: 248  AWY---------QAMAPGRGSCAHDEFRCDQLICL--LPDSVCDGFA--NCADG------ 288
              +         +   P        +F     +     P    +G A   C  G      
Sbjct: 1029 ITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWS 1088

Query: 289  SDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSL 348
            S    C A+   CG ++TG QGT  +P++   Y +   C + I    G  I+L+   F L
Sbjct: 1089 SPLPRCVAE---CGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFEL 1145

Query: 349  EAQDECKFDYVEVYETSSSGAFSLLGRFCGAE-PPPHLVSSHHELAVLFRTDHGISSGGF 407
                  + D ++VY+ +++ A  LLG F  +E     L S+   L + F TD   +S GF
Sbjct: 1146 S-----EGDVLKVYDGNNNSA-RLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGF 1199

Query: 408  SATYLAF 414
               + +F
Sbjct: 1200 ELHFSSF 1206



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 6/120 (5%)

Query: 301  CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
            CGGN+T   GT  +P +   Y     C W I+VP GH + L   N SL  Q E   D++ 
Sbjct: 2182 CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRL---NLSL-LQTEPSGDFIT 2237

Query: 361  VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
            +++     A   LG F  +     + SS +++ + F  D   + G F+  + A+  T+ P
Sbjct: 2238 IWDGPQQTA-PRLGVFTRSMAKKTVQSSSNQVLLKFHRD-AATGGIFAIAFSAYPLTKCP 2295


>gi|126091152 cubilin [Homo sapiens]
          Length = 3623

 Score =  123 bits (308), Expect = 5e-28
 Identities = 90/283 (31%), Positives = 115/283 (40%), Gaps = 59/283 (20%)

Query: 141  QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
            Q  CG  L+G  G   SP +P+ YP    C W I       I L      I S A C  D
Sbjct: 814  QVACGDELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETD 872

Query: 201  RLEL-------SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM 253
             +E+       SPE +    + CG   P  + +  + L V FV  SS E  GF A +   
Sbjct: 873  YVEIGSSSILGSPENK----KYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKF--- 925

Query: 254  APGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFS 313
                                                     SA+   CG  LT   GT  
Sbjct: 926  -----------------------------------------SAEDLACGEILTESTGTIQ 944

Query: 314  TPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
            +P +   YPH + CTWHI V   H I L F  F LE    C  DY+EVY+T S    + L
Sbjct: 945  SPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSE---TSL 1001

Query: 374  GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNA 416
            GR+CG   PP L SS + L ++F TD  ++  GF   Y A +A
Sbjct: 1002 GRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISA 1044



 Score =  117 bits (294), Expect = 2e-26
 Identities = 83/263 (31%), Positives = 118/263 (44%), Gaps = 49/263 (18%)

Query: 153  GFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIE-SVASCLFDRLELSPE--PE 209
            G F+SPN+P+ YP N  C++ I V T   I +     S+E ++ +   D LE+      +
Sbjct: 1057 GTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEK 1116

Query: 210  GPLLRVC-GRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCD 268
             PLL +  G   PPT+ ++++ L + F SD      GF A++                  
Sbjct: 1117 SPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW------------------ 1158

Query: 269  QLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCT 328
                              DGS         +GCGGNLT   GTF +P+Y   Y H   C 
Sbjct: 1159 ------------------DGSS--------TGCGGNLTTSSGTFISPNYPMPYYHSSECY 1192

Query: 329  WHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSS 388
            W +    G + EL+F +F LE    C  DY+ VY+  SS +  LL + CG E PP + SS
Sbjct: 1193 WWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNS-HLLTQLCGDEKPPLIRSS 1251

Query: 389  HHELAVLFRTDHGISSGGFSATY 411
               + +  RTD G    GF A Y
Sbjct: 1252 GDSMFIKLRTDEGQQGRGFKAEY 1274



 Score =  115 bits (288), Expect = 1e-25
 Identities = 86/290 (29%), Positives = 127/290 (43%), Gaps = 56/290 (19%)

Query: 143  TCGGLLSGPRGFFSSPNYP-DPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDR 201
            +CGG+ +   G  +SP Y    YP + HC++ I V+ D  I+LK     +    SC  D 
Sbjct: 3036 SCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDY 3095

Query: 202  LEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFH-AWYQAMAPGR 257
            L +        PLL + CG   PP + ++ + +L+VF +DS     G+  ++ Q + P +
Sbjct: 3096 LAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQ 3155

Query: 258  GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
            G                                          CGG LTG   TF++P  
Sbjct: 3156 G------------------------------------------CGGYLTGSNNTFASPDS 3173

Query: 318  LQQ--YPHQLLCTWHISVPAGHSIELQFHNFSLEA---QDECKFDYVEVYETSSSGAFSL 372
                 Y   L C W I  P    I L F+ F+LEA   +  C +DYV++Y+  S  A +L
Sbjct: 3174 DSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENA-NL 3232

Query: 373  LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
             G FCG+  P   +SS + L V F +D  +   GF+ATY      + PCG
Sbjct: 3233 AGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY---TIMDMPCG 3279



 Score =  114 bits (285), Expect = 2e-25
 Identities = 83/285 (29%), Positives = 130/285 (45%), Gaps = 56/285 (19%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            CG +L+   G   SP +P+ YP   +C WHI V  +H I L  E   +E   +C  D LE
Sbjct: 932  CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLE 991

Query: 204  L-SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAH 262
            +   + E  L R CG+  PP+L ++ + L++VFV+DS +   GF   Y+A++        
Sbjct: 992  VYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAA------ 1045

Query: 263  DEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYP 322
                                                + C  + T   GTF++P++   YP
Sbjct: 1046 ------------------------------------TACLQDYTDDLGTFTSPNFPNNYP 1069

Query: 323  HQLLCTWHISVPAGHSIELQFHNFSL-EAQDECKFDYVEV----YETSSSGAFSLLGRFC 377
            +   C + I+V  G  I + F NFSL EA      D++E+    YE S      LLG F 
Sbjct: 1070 NNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKS-----PLLGIFY 1124

Query: 378  GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
            G+  PP ++S  ++L + F++D   +  GFSA +   + +   CG
Sbjct: 1125 GSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW---DGSSTGCG 1166



 Score =  114 bits (285), Expect = 2e-25
 Identities = 89/316 (28%), Positives = 128/316 (40%), Gaps = 69/316 (21%)

Query: 127  TPKGQQESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQL 184
            T +GQQ  G     + TC    +++   G   S  YP+PY  N HC W I+  T + +  
Sbjct: 1261 TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY 1320

Query: 185  KIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
               A  +E   +C  D LEL   P   + R CG   PP  +T +S L V+          
Sbjct: 1321 TFLAFDLEHHINCSTDYLELYDGPR-QMGRYCGVDLPPPGSTTSSKLQVL---------- 1369

Query: 245  GFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS--GCG 302
                                        LL D V         G  E     ++   GCG
Sbjct: 1370 ----------------------------LLTDGV---------GRREKGFQMQWFVYGCG 1392

Query: 303  GNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVY 362
            G L+G  G+FS+P +  +YP    C W+I    G SI+L  H+F +E    C FD +E+Y
Sbjct: 1393 GELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIY 1452

Query: 363  --ETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
                  S   + L      E P  + S+ +ELA+ F+TD  I+  GF+A++ A       
Sbjct: 1453 GGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAV------ 1506

Query: 421  CGPSELSCQAGGCKGV 436
                      GGC G+
Sbjct: 1507 ---------TGGCGGI 1513



 Score =  113 bits (283), Expect = 4e-25
 Identities = 91/315 (28%), Positives = 131/315 (41%), Gaps = 61/315 (19%)

Query: 105  LPAGGLTTTTTTPTITTSQAAGT-PKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDP 163
            LP  G TT++    +  +   G   KG Q           CGG LSG  G FSSP +P+ 
Sbjct: 1355 LPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYG----CGGELSGATGSFSSPGFPNR 1410

Query: 164  YPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL--SPEPEGP-LLRVC-GRV 219
            YPPN  C+W+I+     +IQL I    +E  + C FD LE+   P+   P + ++C  R 
Sbjct: 1411 YPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRS 1470

Query: 220  P--PPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDS 277
            P  P  +++  + L + F +D S+ G GF+A +QA+                        
Sbjct: 1471 PENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT----------------------- 1507

Query: 278  VCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGH 337
                                  GCGG      G   +P+Y   Y     C+W I V   H
Sbjct: 1508 ---------------------GGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNH 1546

Query: 338  SIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPH-LVSSHHELAVLF 396
             + L F +F LE QD C   Y        S   S L R CG E   + +VSS + L + F
Sbjct: 1547 RVLLNFTDFDLEPQDSCIMAY-----DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRF 1601

Query: 397  RTDHGISSGGFSATY 411
            ++     + GF A +
Sbjct: 1602 QSGPSRQNRGFRAQF 1616



 Score =  113 bits (283), Expect = 4e-25
 Identities = 86/298 (28%), Positives = 126/298 (42%), Gaps = 52/298 (17%)

Query: 131  QQESGVSPSPQSTCGG-LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATD-HAIQLKIEA 188
            +Q  G     +  CGG +L+      SSP +P  YP N +C W IQ     + I L    
Sbjct: 1607 RQNRGFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTH 1666

Query: 189  LSIESVASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFG 245
              +E   +C  D +E+      + PL  R CG   P  + + +S L + FVSDSS+   G
Sbjct: 1667 FELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGG 1726

Query: 246  FHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNL 305
            FH                                            T  +A  S CGG  
Sbjct: 1727 FH--------------------------------------------TTVTASVSACGGTF 1742

Query: 306  TGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETS 365
               +G F++P Y   YP  + C W+I    G+ ++L F +F LE   +C  D+VE+ E +
Sbjct: 1743 YMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGN 1802

Query: 366  SSGAFSLLGRFCGAEPPPHLVS-SHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
            ++G   L+GR+CG   P +  S   H L V F +D   S  GF AT++     +N  G
Sbjct: 1803 ATG--HLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVG 1858



 Score =  109 bits (272), Expect = 8e-24
 Identities = 75/284 (26%), Positives = 120/284 (42%), Gaps = 49/284 (17%)

Query: 144  CGGLLSGPRGFFSSPNYPD-PYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRL 202
            CGG + G  G   S  +P  PY  N  C WH+Q  + H + +  E  ++++ + C  D +
Sbjct: 2336 CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFV 2395

Query: 203  EL-SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
            E+      G +L R CG   P +++T+++  +V FV+D SV   GF   +++        
Sbjct: 2396 EIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFES-------- 2447

Query: 261  AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
                                                    CGG+L G  GTF++P+Y   
Sbjct: 2448 ------------------------------------SMEECGGDLQGSIGTFTSPNYPNP 2471

Query: 321  YPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAE 380
             PH  +C W I+ P G  I L F+N  L     C  ++V V+    S +  L        
Sbjct: 2472 NPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVN 2531

Query: 381  PPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPS 424
                + SS + + V+F TD     GGF+A+Y   ++ +  CG S
Sbjct: 2532 VSNEIKSSGNTMKVIFFTDGSRPYGGFTASYT--SSEDAVCGGS 2573



 Score =  107 bits (266), Expect = 4e-23
 Identities = 82/292 (28%), Positives = 120/292 (41%), Gaps = 55/292 (18%)

Query: 128  PKGQQESGVSPSPQSTCGGLLSG-PRGFFSSPNYPDP--YPPNTHCVWHIQVAT--DHAI 182
            P G   +  + S  + CGG L   P G F+SP Y     Y  N +C W +      + +I
Sbjct: 2554 PYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSI 2613

Query: 183  QLKIEALSIESVASCLFDRLELSP-EPEGPLL-RVCGRVPPPT-LNTNASHLLVVFVSDS 239
             +  E   +ES   C FD LE    + +GPL+ R+CG   P   L    S + + FV++ 
Sbjct: 2614 SIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNE 2673

Query: 240  SVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS 299
             VE  GFHA Y                                               F+
Sbjct: 2674 RVEHIGFHAKYS----------------------------------------------FT 2687

Query: 300  GCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYV 359
             CGG   G  G  ++P+Y   Y     C+  +  P GH+I L F +F +E    C +D V
Sbjct: 2688 DCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSV 2747

Query: 360  EVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
             V     S    ++G++CG   P  + S  ++L V F +DH +  GGF AT+
Sbjct: 2748 TV-RNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATW 2798



 Score =  106 bits (265), Expect = 5e-23
 Identities = 73/274 (26%), Positives = 104/274 (37%), Gaps = 50/274 (18%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           Q  CGG+L+GP G   SP YP  YPP   CVW +  + D  +      LS+E    C  D
Sbjct: 587 QPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKD 646

Query: 201 RLELSPEP--EGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
            LE+   P  + PLL + C     P L T      + F SDS +   GFH  Y       
Sbjct: 647 YLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT----- 701

Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
                                                S     CGGN T  +G    P  
Sbjct: 702 -------------------------------------SPSDLRCGGNYTDPEGELFLPEL 724

Query: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
              + H   C + +  P G  I++ F +  L+ Q +   +Y+EV +       +LLG+ C
Sbjct: 725 SGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGE-----TLLGKVC 779

Query: 378 GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
           G     H+ S  + + + F+ D  +    F A Y
Sbjct: 780 GNGTISHIKSITNSVWIRFKIDASVEKASFRAVY 813



 Score =  104 bits (260), Expect = 2e-22
 Identities = 83/283 (29%), Positives = 115/283 (40%), Gaps = 57/283 (20%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            CGG+   P G   SPNYP PY  NT C W I+V  +H + L      +E   SC+     
Sbjct: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDG 1569

Query: 204  LSPEPEGPLLRVCGR--VPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCA 261
            LS      L R CGR  +  P +++  S L + F S  S +  GF A ++          
Sbjct: 1570 LS-STMSRLARTCGREQLANPIVSSGNS-LFLRFQSGPSRQNRGFRAQFR---------- 1617

Query: 262  HDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGN-LTGLQGTFSTPSYLQQ 320
                                                   CGG+ LT    T S+P +   
Sbjct: 1618 -------------------------------------QACGGHILTSSFDTVSSPRFPAN 1640

Query: 321  YPHQLLCTWHISV-PAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGA 379
            YP+   C+W I   P  + I L F +F LE    C  D+VE+ +     A  L GR+CG 
Sbjct: 1641 YPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDA-PLRGRYCGT 1699

Query: 380  EPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
            + P  + S    L + F +D  IS+GGF  T     A+ + CG
Sbjct: 1700 DMPHPITSFSSALTLRFVSDSSISAGGFHTT---VTASVSACG 1739



 Score =  104 bits (260), Expect = 2e-22
 Identities = 83/329 (25%), Positives = 136/329 (41%), Gaps = 59/329 (17%)

Query: 105  LPAGGLTTTTTTPTITTSQAAGTPKGQQES---GVSPSPQSTCGGLLSGPRGFFSSPNYP 161
            L A G       P IT S         QE+   G S S  S CG   +GP G+  SPNYP
Sbjct: 2878 LLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYP 2937

Query: 162  DPYPPNTHCVWHIQVATDHAIQLKIEALSIES----VASCLFDRLELS---PEPEGPLLR 214
              Y  N +C + I+      + L   +  +E+      SC+ D + +         P   
Sbjct: 2938 KQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFAT 2997

Query: 215  VCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLL 274
            VCG   P  L T A  +L+ F S+  +  FGF   Y+ ++                    
Sbjct: 2998 VCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKFSYRIIS-------------------- 3036

Query: 275  PDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY-LQQYPHQLLCTWHISV 333
                                      CGG      G  ++P+Y    YP+ + C + I+V
Sbjct: 3037 --------------------------CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITV 3070

Query: 334  PAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELA 393
                 IEL+F +F +     C  DY+ +Y+ +++    LLG+FCG++ PP++ SS++ + 
Sbjct: 3071 SDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSD-PLLGKFCGSKRPPNVKSSNNSML 3129

Query: 394  VLFRTDHGISSGGFSATYLAFNATENPCG 422
            ++F+TD   ++ G+  ++      +  CG
Sbjct: 3130 LVFKTDSFQTAKGWKMSFRQTLGPQQGCG 3158



 Score =  103 bits (257), Expect = 4e-22
 Identities = 74/288 (25%), Positives = 124/288 (43%), Gaps = 60/288 (20%)

Query: 144  CGGLL----SGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIE-ALSIESVASCL 198
            CGG +    +   G+ +SPN+P  YPP+  C+W +    +  IQL+ E    IE   +C 
Sbjct: 2217 CGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCT 2276

Query: 199  FDRLELSP--EPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAP 255
             + LEL    + + P+L + CG   P +  ++   + + F SD+S    GF A Y     
Sbjct: 2277 SNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYS---- 2332

Query: 256  GRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTP 315
                                                       + CGG + G  G   + 
Sbjct: 2333 ------------------------------------------IAQCGGRVPGQSGVVESI 2350

Query: 316  SY-LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG 374
             +    Y   L C WH+   +GH + + F +F+L+    C+ D+VE+++  +SG  ++LG
Sbjct: 2351 GHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSG--NILG 2408

Query: 375  RFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
            R+CG   P  + +S +   V F TD  +++ GF    L F ++   CG
Sbjct: 2409 RYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFR---LRFESSMEECG 2453



 Score =  102 bits (255), Expect = 7e-22
 Identities = 86/329 (26%), Positives = 130/329 (39%), Gaps = 60/329 (18%)

Query: 102  HSPLPAGGLTTTTTTP-TITTSQAAGTPKGQQESGVSP--------SPQSTCGGLLSGPR 152
            H   P  G    T  P  IT+  +A T +   +S +S         +  S CGG      
Sbjct: 1687 HEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGGTFYMAE 1746

Query: 153  GFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL-SPEPEGP 211
            G F+SP YPD YPPN  CVW+I  +  + +QL   +  +E    C  D +E+      G 
Sbjct: 1747 GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGH 1806

Query: 212  LL-RVCGRVPPPTLNTNASHLL-VVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQ 269
            L+ R CG   P   ++   H L V F+SD S  G GF A +  +                
Sbjct: 1807 LVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKI---------------- 1850

Query: 270  LICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTW 329
                        F N                   N+ G  G  ++P + + YPH     W
Sbjct: 1851 ------------FGN------------------DNIVGTHGKVASPFWPENYPHNSNYQW 1880

Query: 330  HISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSH 389
             ++V A H +  +     +E    C +D + +Y+  S  A  L+G +CG +      S+ 
Sbjct: 1881 TVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA-RLIGAYCGTQ-TESFSSTG 1938

Query: 390  HELAVLFRTDHGISSGGFSATYLAFNATE 418
            + L   F +D  IS  GF   + A +A +
Sbjct: 1939 NSLTFHFYSDSSISGKGFLLEWFAVDAPD 1967



 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 80/295 (27%), Positives = 119/295 (40%), Gaps = 62/295 (21%)

Query: 134  SGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEA--LSI 191
            +G + S   +CGG L   RG  +SP YP+ YP N +C WH+ V +   I +  E      
Sbjct: 2082 AGFNASFHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIP 2141

Query: 192  ESVASC-------LFDRLELSPEPEGP---LLRVCGRVPPPTLNTNASHLLVVFVSDSSV 241
               +SC       L +  ++   P GP       CG     TL T+ + + V F+SD S 
Sbjct: 2142 NGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSN 2201

Query: 242  EGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGC 301
            EG GF   Y+                                            AK   C
Sbjct: 2202 EGQGFKIKYE--------------------------------------------AKSLAC 2217

Query: 302  GGNL----TGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHN-FSLEAQDECKF 356
            GGN+        G  ++P++   YP    C W ++ P    I+LQF + F +E    C  
Sbjct: 2218 GGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTS 2277

Query: 357  DYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
            +Y+E+ +   S A  +L +FCG   P    SS   + + FR+D+  +  GF A Y
Sbjct: 2278 NYLELRDGVDSDA-PILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY 2331



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 70/286 (24%), Positives = 120/286 (41%), Gaps = 51/286 (17%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            CGG+  G  G  +SPNYP+ Y   THC   ++    H I L      IE   +C +D + 
Sbjct: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748

Query: 204  L--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
            +     PE P++ + CG   P T+ + ++ L+V F SD S++G GF+A +     G G  
Sbjct: 2749 VRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGI 2808

Query: 261  AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
             H +                                             GT  +P + Q 
Sbjct: 2809 FHSD--------------------------------------------NGTIRSPHWPQN 2824

Query: 321  YPHQLLCTWHISVPAGHSIELQF-HNFSLEAQD-ECKFDYVEVYETSSSGAFSLLGRFCG 378
            +P    C+W         +E+ F +NF + + D +C+  +V+V+  +     +LL   CG
Sbjct: 2825 FPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCG 2884

Query: 379  AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPS 424
               P  +++  +    +F++     + GFSA++++     N  GPS
Sbjct: 2885 NVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVS-RCGSNFTGPS 2928



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 78/293 (26%), Positives = 114/293 (38%), Gaps = 62/293 (21%)

Query: 135  GVSPS-PQSTCGGLLSGPRG--FFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI 191
            GV P+     CGG L       F  SP +PD Y     C W IQ A D  ++L I +L I
Sbjct: 1968 GVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQ-APDSTVELNILSLDI 2026

Query: 192  ESVASCLFDRLELSPEPEG---PLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHA 248
            ES  +C +D L +          L  +CGR  P  + +   ++ + F SDSSV   GF+A
Sbjct: 2027 ESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNA 2086

Query: 249  WYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGL 308
             +                                                  CGG L   
Sbjct: 2087 SFH-----------------------------------------------KSCGGYLHAD 2099

Query: 309  QGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHN-FSLEAQDEC--KFDYVEVYE-- 363
            +G  ++P Y + YP  L C+WH+ V +G +I + F   F +   D    + DY+ +    
Sbjct: 2100 RGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGP 2159

Query: 364  ---TSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
               +   G     G FCG+     L +S +++ V F +DH     GF   Y A
Sbjct: 2160 DICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEA 2212



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 72/292 (24%), Positives = 113/292 (38%), Gaps = 60/292 (20%)

Query: 144  CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
            CGG L+   G F SPNYP PY  ++ C W ++ +   A +L+ +   +E   +C  D L 
Sbjct: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224

Query: 204  LSPEPEGP---LLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
            +   P      L ++CG   PP + ++   + +   +D   +G GF A Y+         
Sbjct: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQ-------- 1276

Query: 261  AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
                  C+ ++ +                              N T   G   +  Y   
Sbjct: 1277 -----TCENVVIV------------------------------NQT--YGILESIGYPNP 1299

Query: 321  YPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAE 380
            Y     C W I    G+++   F  F LE    C  DY+E+Y+         +GR+CG +
Sbjct: 1300 YSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQ-----MGRYCGVD 1354

Query: 381  PPPHLVSSHHELAVLFRTDH-GISSGGFSATYLAFNATENPCGPSELSCQAG 431
             PP   ++  +L VL  TD  G    GF   +  +      CG  ELS   G
Sbjct: 1355 LPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYG-----CG-GELSGATG 1400



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 76/286 (26%), Positives = 119/286 (41%), Gaps = 61/286 (21%)

Query: 139  SPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC- 197
            S    CGG L G  G F+SPNYP+P P    C W I       I L    L + +  SC 
Sbjct: 2447 SSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCN 2506

Query: 198  -----LFDRLELSPEPEGPLLRVCGRVPPPT-LNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
                 +F+ +  S  P+  L ++C  V     + ++ + + V+F +D S    GF A Y 
Sbjct: 2507 NEHVIVFNGIR-SNSPQ--LEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY- 2562

Query: 252  AMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGL-QG 310
                                                       S++ + CGG+L    +G
Sbjct: 2563 ------------------------------------------TSSEDAVCGGSLPNTPEG 2580

Query: 311  TFSTPSY--LQQYPHQLLCTWHISVP--AGHSIELQFHNFSLEAQDECKFDYVEVYETSS 366
             F++P Y  ++ Y   L C W +S P     SI + F +F LE+  +C+FD +E     +
Sbjct: 2581 NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDA 2640

Query: 367  SGAFSLLGRFCG-AEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
             G   L+ R CG ++P   LV  + ++ + F T+  +   GF A Y
Sbjct: 2641 DG--PLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 63/263 (23%), Positives = 107/263 (40%), Gaps = 49/263 (18%)

Query: 153  GFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL--SPEPEG 210
            G   SP +PD Y  +  C   +    +H I L   +L IE+   C  D LE+        
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463

Query: 211  PLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQ 269
            PLL + CG + P  + +  + L + F SDS     G+                       
Sbjct: 3464 PLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY----------------------- 3500

Query: 270  LICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTW 329
                                 E   ++  SGCGG L G +G+F++P Y   YP+   C W
Sbjct: 3501 ---------------------EIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEW 3539

Query: 330  HISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPP-PHLVSS 388
             +  PAG  + + F+  S++   +C  +Y+ +Y+  ++ + S  G +CG +      V+S
Sbjct: 3540 VLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPS-SGPYCGGDTSIAPFVAS 3598

Query: 389  HHELAVLFRTDHGISSGGFSATY 411
             +++ + F  D+      F  T+
Sbjct: 3599 SNQVFIKFHADYARRPSAFRLTW 3621



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 60/265 (22%), Positives = 110/265 (41%), Gaps = 37/265 (13%)

Query: 150  GPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLEL--SPE 207
            G  G  +SP +P+ YP N++  W + V   H +  +I  + IE + +C +D+L +   P 
Sbjct: 1858 GTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPS 1917

Query: 208  PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHA-WYQAMAPGRGSCAHDEFR 266
                L+         + ++  + L   F SDSS+ G GF   W+   AP           
Sbjct: 1918 IHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAP----------- 1966

Query: 267  CDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLL 326
             D ++  +    C GF    D                          +P +   Y +++ 
Sbjct: 1967 -DGVLPTIAPGACGGFLRTGDAPV--------------------FLFSPGWPDSYSNRVD 2005

Query: 327  CTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLV 386
            CTW I  P   ++EL   +  +E+   C +D + + +  ++ A   L   CG E P  + 
Sbjct: 2006 CTWLIQAPDS-TVELNILSLDIESHRTCAYDSLVIRDGDNNLA-QQLAVLCGREIPGPIR 2063

Query: 387  SSHHELAVLFRTDHGISSGGFSATY 411
            S+   + + F +D  ++  GF+A++
Sbjct: 2064 STGEYMFIRFTSDSSVTRAGFNASF 2088



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 75/292 (25%), Positives = 108/292 (36%), Gaps = 56/292 (19%)

Query: 140 PQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLF 199
           PQ  CG  LSG  G FS  +    Y  + +C W I+      +++      +ES+ +C  
Sbjct: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPH 529

Query: 200 DRLELSPEPEGP---LLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
           + L++          L R CG   P        H L+     SS     FH + + +  G
Sbjct: 530 EFLQVYDGDSSSAFQLGRFCGSSLP--------HELL-----SSDNALYFHLYSEHLRNG 576

Query: 257 RGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
           RG     E +  +                               CGG LTG  G+  +P 
Sbjct: 577 RGFTVRWETQQPE-------------------------------CGGILTGPYGSIKSPG 605

Query: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRF 376
           Y   YP    C W +       +   F   SLE  D+C  DY+E+ +        LLG+F
Sbjct: 606 YPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRD-GPLYQDPLLGKF 664

Query: 377 CGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSC 428
           C     P L ++     + F +D  IS  GF  TYL          PS+L C
Sbjct: 665 CTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT--------SPSDLRC 708



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 51/156 (32%), Positives = 76/156 (48%), Gaps = 17/156 (10%)

Query: 279 CDGFANCADGSDETNCSAK--FSG---------CGGNLTGLQGTFSTPSYLQQYPHQLLC 327
           C     C DG D  +C     ++G         CG +L+G+ G+FS  S    Y H + C
Sbjct: 441 CLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNC 500

Query: 328 TWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVS 387
            W I    G  + + F  F LE+ D C  ++++VY+  SS AF  LGRFCG+  P  L+S
Sbjct: 501 FWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQ-LGRFCGSSLPHELLS 559

Query: 388 SHHELAVLFRTDHGISSGGFSATYLAFNATENP-CG 422
           S + L     ++H  +  GF+  +     T+ P CG
Sbjct: 560 SDNALYFHLYSEHLRNGRGFTVRW----ETQQPECG 591



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 56/285 (19%)

Query: 144  CGGLLSG---PRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
            CGG  +    P+   SSPN  DP  P + C W I       +++ + AL + S   C  +
Sbjct: 3278 CGGTYNATWTPQNI-SSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTS-QDCTQN 3335

Query: 201  RLELSPEPEG---PLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
             L+L   P+G      + CGR        NAS + V + S S+                 
Sbjct: 3336 YLQLQDSPQGHGNSRFQFCGR--------NASAVPVFYSSMSTA---------------- 3371

Query: 258  GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
                         + +    V +  +  +      +C+  +    GNL        +P +
Sbjct: 3372 -------------MVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLR-------SPGW 3411

Query: 318  LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFC 377
               Y +   CT  ++ P  H+I L FH+  +E   EC+ D++EV   S+S +  LLG++C
Sbjct: 3412 PDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS-PLLGKYC 3470

Query: 378  GAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
            G   P  + S ++EL + F++D   S  G+    + + ++ + CG
Sbjct: 3471 GTLLPNPVFSQNNELYLRFKSDSVTSDRGYE---IIWTSSPSGCG 3512



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 66/284 (23%), Positives = 106/284 (37%), Gaps = 63/284 (22%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CGG  + P G    P    P+     CV+ ++      IQ+    + ++  +    + +E
Sbjct: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767

Query: 204 LSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHD 263
           +  + E  L +VCG      + +  + + + F  D+SVE   F A YQ            
Sbjct: 768 VR-DGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV----------- 815

Query: 264 EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPH 323
                                                CG  LTG +G   +P +   YP 
Sbjct: 816 ------------------------------------ACGDELTG-EGVIRSPFFPNVYPG 838

Query: 324 QLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG-----RFCG 378
           +  C W I  P    I L F  F + +   C+ DYVE+      G+ S+LG     ++CG
Sbjct: 839 ERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI------GSSSILGSPENKKYCG 892

Query: 379 AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
            + P  + S ++ L V F       + GF A    F+A +  CG
Sbjct: 893 TDIPSFITSVYNFLYVTFVKSSSTENHGFMA---KFSAEDLACG 933



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 69/282 (24%), Positives = 107/282 (37%), Gaps = 54/282 (19%)

Query: 140  PQSTCGGLLSGPRGFFSSPNYPDP--YPPNTHCVWHIQVATDHAIQLKIEALSIESVAS- 196
            PQ  CGG L+G    F+SP+      Y  N +CVW I    +  I L     ++E+ ++ 
Sbjct: 3153 PQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTR 3212

Query: 197  --CLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ 251
              CL+D ++L     E        CG   P    ++ + L V F+SD ++E  GF+A Y 
Sbjct: 3213 QRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYT 3272

Query: 252  AMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGT 311
             M                      D  C G  N                     T     
Sbjct: 3273 IM----------------------DMPCGGTYNA--------------------TWTPQN 3290

Query: 312  FSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFS 371
             S+P+         +CTW I  P    +++      L +QD C  +Y+++ + S  G  +
Sbjct: 3291 ISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQL-QDSPQGHGN 3348

Query: 372  LLGRFCG--AEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
               +FCG  A   P   SS     V+F++     +   S TY
Sbjct: 3349 SRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTY 3390



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 37/118 (31%), Positives = 48/118 (40%), Gaps = 19/118 (16%)

Query: 139  SPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC- 197
            S  S CGG L G RG F+SP YP  YP NT+C W +       + +    +SI+    C 
Sbjct: 3506 SSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCV 3565

Query: 198  -----LFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
                 L+D    S    GP    CG              +  FV+ S+     FHA Y
Sbjct: 3566 QNYLTLYDGPNASSPSSGP---YCG----------GDTSIAPFVASSNQVFIKFHADY 3610


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  122 bits (306), Expect = 9e-28
 Identities = 92/312 (29%), Positives = 138/312 (44%), Gaps = 42/312 (13%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            PS    C G  +  RG   SP YP+PY  N +C+W I V     IQ+++ + + E     
Sbjct: 1797 PSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN--- 1853

Query: 198  LFDRLELSPEPEGPLLRV---CGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA 254
             +D LE+    +    R+    G   P  LN+ ++ L + F SD SV   GFH  Y+ + 
Sbjct: 1854 -WDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVG 1912

Query: 255  ---------PGRGSCAHDEFRCDQLICLL--PDSVCDGFAN--CADGS------DETNCS 295
                     P       D +  + ++     P     G ++  C  G+          C 
Sbjct: 1913 LAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCI 1972

Query: 296  AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
            A    CGG L+ L G   +P +   YP+ L CTW IS+P G+   +QF NFS EA     
Sbjct: 1973 AT---CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEA----N 2025

Query: 356  FDYVEV----YETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
             D++E+    Y TS      ++G+F G + P  L+S+ HE  + F +DH  +  GF   Y
Sbjct: 2026 HDFLEIQNGPYHTS-----PMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAY 2080

Query: 412  LAFNATENPCGP 423
             A+     P  P
Sbjct: 2081 QAYELQNCPDPP 2092



 Score =  110 bits (275), Expect = 4e-24
 Identities = 86/299 (28%), Positives = 127/299 (42%), Gaps = 35/299 (11%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVA-TDHAIQLKIEALSIESVASCLFDR 201
           TCG  L GP G  +SPNYP  Y  N HCVW I     D  I+L  E   +E      +D 
Sbjct: 411 TCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDT 466

Query: 202 LELSP-----EPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPG 256
           L +       +    L  + G   P  + + ++ + +   SD S+   GF A YQ +  G
Sbjct: 467 LTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKG 526

Query: 257 --------------RGSCAHDE---FRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS 299
                           S  H +   F C     L+ + V     N     ++ +C     
Sbjct: 527 GCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC---VF 583

Query: 300 GCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYV 359
            C  N T   G   +P+Y ++Y + + C W I    G  I L F++F +E Q    FD++
Sbjct: 584 SCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQ----FDFL 639

Query: 360 EVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
            V +   S   ++LG F G E P  L SS H + + F++DH  +  GF+ TY  F   E
Sbjct: 640 AVKDDGISD-ITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNE 697



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 89/326 (27%), Positives = 126/326 (38%), Gaps = 54/326 (16%)

Query: 129 KGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEA 188
           +  Q SG  PS   +C    +   G   SPNYP+ Y  N +CVW I       I L    
Sbjct: 570 QNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFND 629

Query: 189 LSIESVASCLFDRLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFG 245
             +E      FD L +  +    +       G   P  L ++   + + F SD S  G G
Sbjct: 630 FDVEP----QFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRG 685

Query: 246 FHAWYQAMAPGRGSCAHD--------------------EFRCD----------QLICLLP 275
           F+  Y     G+  C HD                     F CD           + C+L 
Sbjct: 686 FNITYTTF--GQNEC-HDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQ 742

Query: 276 DSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPA 335
           D       N    S    C A    CGG+LT   G    P +   Y   L C W I    
Sbjct: 743 D------GNVVWSSTVPRCEAP---CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKP 793

Query: 336 GHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVL 395
           GHSI++ F  F    Q E  +D +EV +  +S +  L+G + G + P  L+S+ + + +L
Sbjct: 794 GHSIKITFDRF----QTEVNYDTLEVRDGPASSS-PLIGEYHGTQAPQFLISTGNFMYLL 848

Query: 396 FRTDHGISSGGFSATYLAFNATENPC 421
           F TD+  SS GF   Y +     + C
Sbjct: 849 FTTDNSRSSIGFLIHYESVTLESDSC 874



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 80/298 (26%), Positives = 121/298 (40%), Gaps = 36/298 (12%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
           CGGL+ GP G   SP +P  YP   +C W I     + IQL     ++E      FD L 
Sbjct: 32  CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87

Query: 204 L---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA------ 254
           +    P+     +R+ G   P ++ +  S L + F +D +V   GF A Y+ +       
Sbjct: 88  VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147

Query: 255 PG---RGSCAHDEFRCDQLI--CLLPDSVCDGFA---------NCADGSDETNCSAKFSG 300
           PG   +G      F     I    LP  + +G A         N A              
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGA 207

Query: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
           CGG L G   + S+P +  +Y +   CTW I    G +I L F +F LE      +D++E
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEE----GYDFLE 263

Query: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
           +  T +   +       G   P  ++SS + L + F +D      GF+A +    A E
Sbjct: 264 ISGTEAPSIW-----LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE 316



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 84/317 (26%), Positives = 131/317 (41%), Gaps = 48/317 (15%)

Query: 134  SGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIES 193
            S   P  ++ CGG L+   G    P +P  Y  + HC W I+    H+I++  +    E 
Sbjct: 749  SSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTE- 807

Query: 194  VASCLFDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
                 +D LE+   P    PL+    G   P  L +  + + ++F +D+S    GF   Y
Sbjct: 808  ---VNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHY 864

Query: 251  QAMAPGRGSCAHD-------------------EFRCDQLICLLPDS--VCDGFANCADGS 289
            +++     SC                       F CD    L  D   VC+   N     
Sbjct: 865  ESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCE--RNHQWNH 922

Query: 290  DETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE 349
               +C A    CGG + G  GT  +P +   YP+ L CTW I V  G  +++ FH F LE
Sbjct: 923  ALPSCDAL---CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE 979

Query: 350  AQDECKFDYVEVYETSSSGAFS-LLGRFCGAEPPPHLVSS----HHELAVLFRTDHGISS 404
            +      DY+ + E    G+FS  + R  G+   PH + +    +    + F +D  IS 
Sbjct: 980  S----SHDYLLITE---DGSFSEPVARLTGS-VLPHTIKAGLFGNFTAQLRFISDFSISY 1031

Query: 405  GGFSATYLAFNATENPC 421
             GF+ T+  ++    PC
Sbjct: 1032 EGFNITFSEYDL--EPC 1046



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 82/307 (26%), Positives = 130/307 (42%), Gaps = 38/307 (12%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P+  + CGG L+GP G   SPNYP PYPP   C W ++V  D  I L  ++ ++E   S 
Sbjct: 1446 PTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNME--PSY 1503

Query: 198  LFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQ----- 251
             F  +    +   PL+    G   P  + ++ + L + F SD+SV   GF   ++     
Sbjct: 1504 DFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPRE 1563

Query: 252  -AMAPG---RGSCAHDEFRCDQLICLLPDS----VCDGFANCADGSDE--------TNCS 295
                PG    G+    +F+    I    DS    +      C  G+D          +C+
Sbjct: 1564 ACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCN 1623

Query: 296  AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
            A    CGG  TG +G   +P+Y   Y    +C + I+VP    +  QF  F         
Sbjct: 1624 AP---CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALN---- 1676

Query: 356  FDYVEVYETSSSGA---FSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYL 412
             D  E+++ + + A    SL G   G   P   +++ +++ + F    G S+ GF   Y 
Sbjct: 1677 -DLAELFDGTHAQARLLSSLSGSHSGETLP---LATSNQILLRFSAKSGASARGFHFVYQ 1732

Query: 413  AFNATEN 419
            A   T +
Sbjct: 1733 AVPRTSD 1739



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 83/292 (28%), Positives = 122/292 (41%), Gaps = 34/292 (11%)

Query: 138  PSPQ--STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVA 195
            PSP   +TCGG LS   G   SP +P  YP N  C W I +   +     I+ L+  + A
Sbjct: 1967 PSPLCIATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAH--IQFLNFSTEA 2024

Query: 196  SCLFDRLELSPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM- 253
            +  F  ++  P    P++ +  G   P  L +     L+ F SD S    GF   YQA  
Sbjct: 2025 NHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYE 2084

Query: 254  ---APG-----RGSCAHDEFRCDQLICL--LPDSVCDG--FANCADGSDET------NCS 295
                P       G   + ++   Q +     P  +  G     C  G +         C 
Sbjct: 2085 LQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144

Query: 296  AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECK 355
            A    CG N+T   GT  +P +  +YP    C W I+VP GH +   + NF+L  Q E  
Sbjct: 2145 AP---CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGV---YINFTL-LQTEAV 2197

Query: 356  FDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGF 407
             DY+ V++     +   LG F G        SS +++ + F +D   S+GGF
Sbjct: 2198 NDYIAVWDGPDQNS-PQLGVFSGNTALETAYSSTNQVLLKFHSD--FSNGGF 2246



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 88/327 (26%), Positives = 130/327 (39%), Gaps = 38/327 (11%)

Query: 124  AAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAI- 182
            A G P   Q   V PS  + CGG  +G  G   SPNYP  Y     C++ I V  +  + 
Sbjct: 1609 ADGKPSWDQ---VLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVF 1665

Query: 183  -QLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSV 241
             Q      ++  +A  LFD           L         P   +N   +L+ F + S  
Sbjct: 1666 GQFAYFQTALNDLAE-LFDGTHAQARLLSSLSGSHSGETLPLATSN--QILLRFSAKSGA 1722

Query: 242  EGFGFHAWYQAMA------------PGRGSCAHDEFRCDQLI-------CLLPDSV---C 279
               GFH  YQA+             P  G     EF    ++        LL  S    C
Sbjct: 1723 SARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHC 1782

Query: 280  DGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSI 339
                N     ++T  S     C GN T  +GT  +P Y + Y + L C W I V  G  I
Sbjct: 1783 QSVPNALAQWNDTIPSCVVP-CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGI 1841

Query: 340  ELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTD 399
            ++Q  +F+ E      +D +E+++     A   LG F G   P  L S+ ++L + F++D
Sbjct: 1842 QIQVISFATEQ----NWDSLEIHDGGDVTA-PRLGSFSGTTVPALLNSTSNQLYLHFQSD 1896

Query: 400  HGISSGGFSATY--LAFNATENPCGPS 424
              +++ GF   Y  +   A + P  PS
Sbjct: 1897 ISVAAAGFHLEYKTVGLAACQEPALPS 1923



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 81/332 (24%), Positives = 128/332 (38%), Gaps = 39/332 (11%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI-ESVAS 196
            P   + CG  + G  G   SPN+P  Y  N  C++ I+      I L+  +  + E    
Sbjct: 1099 PRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTL 1158

Query: 197  CLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAM--- 253
             ++D  + S  P G   +    +    LN+ ++HL + F ++ S    GF   Y +    
Sbjct: 1159 KVYDGKDSSSRPLGTFTK--NELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLV 1216

Query: 254  ------APGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC------------S 295
                   P  G    DE      + L   S   G+A    GS+   C             
Sbjct: 1217 KCEDPGIPNYGYRIRDEGHFTDTVVLY--SCNPGYA--MHGSNTLTCLSGDRRVWDKPLP 1272

Query: 296  AKFSGCGGNL-TGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
            +  + CGG +     G   +P Y   Y + L CTW I    G +I L F  F      E 
Sbjct: 1273 SCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVF----DTEM 1328

Query: 355  KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY-LA 413
              D ++V++        LL  + G+  P  + S+ + L + F +D  IS  GFS  +  +
Sbjct: 1329 AHDILKVWDGPVDSDI-LLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTS 1387

Query: 414  FNATENPCGPSELSCQAGGCK----GVQWMCD 441
              AT N  G  +   + G  +     V + CD
Sbjct: 1388 IAATCNDPGMPQNGTRYGDSREAGDTVTFQCD 1419



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 80/325 (24%), Positives = 120/325 (36%), Gaps = 63/325 (19%)

Query: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
           +  CGG L G     SSP++P  Y  N  C W I       I L      +E      +D
Sbjct: 205 EGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YD 260

Query: 201 RLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQA-------- 252
            LE+S   E P + + G   P  + ++ + L + F SDS+    GF+A +Q         
Sbjct: 261 FLEIS-GTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKS 319

Query: 253 ----MAPGRGSCAHDEFRCDQLICLLPDSVCD------------GFA--------NCAD- 287
               M P +     +       + L+ D   D             F+        +C D 
Sbjct: 320 RGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDN 379

Query: 288 ----GSDETNCS---------------AKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCT 328
               GS    C                 +   CG NL G  G  ++P+Y  QY     C 
Sbjct: 380 YVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCV 439

Query: 329 WHI-SVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSG-AFSLLGRFCGAEPPPHLV 386
           W I +      I+L F  F LE      +D + V +    G   S+L    G+  P  +V
Sbjct: 440 WVITTTDPDKVIKLAFEEFELER----GYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495

Query: 387 SSHHELAVLFRTDHGISSGGFSATY 411
           S  +++ +  ++D  I S GF A Y
Sbjct: 496 SMSNQMWLHLQSDDSIGSPGFKAVY 520



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 75/299 (25%), Positives = 116/299 (38%), Gaps = 32/299 (10%)

Query: 138  PSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASC 197
            P   + CG  ++   G   SP +PD YP    C+W I V   H + +    L  E+V   
Sbjct: 2141 PRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDY 2200

Query: 198  LFDRLELSPEPEGPLLRV-CGRVPPPTLNTNASHLLVVFVSDSSVEGF---GFHAWY--- 250
            +   +   P+   P L V  G     T  ++ + +L+ F SD S  GF    FHA+    
Sbjct: 2201 I--AVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKK 2258

Query: 251  ----QAMAPGRGSCAHDEF--------RCDQLICLLPDSV--CDGFANCADGSDETNCSA 296
                 A+         D+F        +C     L+   +  C   +          C A
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA 2318

Query: 297  KFSGCGGN--LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
            +   C  N   TG  G   +P Y   Y +   C+W I V   ++I +    F    Q E 
Sbjct: 2319 Q---CPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTF----QSEK 2371

Query: 355  KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLA 413
            +FD +EV++ SS  +  L+          +  S  ++L + + TDH  S  GF   Y A
Sbjct: 2372 QFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA 2430



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 77/330 (23%), Positives = 124/330 (37%), Gaps = 52/330 (15%)

Query: 118  TITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVA 177
            T++  +     +  Q +   PS  + CGG + G  G   SP +PD YP + +C W I+V+
Sbjct: 905  TLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVS 964

Query: 178  TDHAIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVV--- 234
                +Q+      +ES    L   +        P+ R+ G V P T+             
Sbjct: 965  HGKGVQMIFHTFHLESSHDYLL--ITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLR 1022

Query: 235  FVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQ---------------------LICL 273
            F+SD S+   GF+  +           +D   CD                        C 
Sbjct: 1023 FISDFSISYEGFNITFS---------EYDLEPCDDPGVPAFSRRIGFHFGVGDSLTFSCF 1073

Query: 274  L-------PDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLL 326
            L           C G       +    C A+   CG ++ G +GT  +P++   Y +   
Sbjct: 1074 LGYRLEGATKLTCLGGGRRVWSAPLPRCVAE---CGASVKGNEGTLLSPNFPSNYDNNHE 1130

Query: 327  CTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLV 386
            C + I   AG  I L+  +F L   D  K     VY+   S +   LG F   E    ++
Sbjct: 1131 CIYKIETEAGKGIHLRTRSFQLFEGDTLK-----VYDGKDSSS-RPLGTFTKNELLGLIL 1184

Query: 387  -SSHHELAVLFRTDHGISSGGFSATYLAFN 415
             S+ + L + F T+   +  GF  TY +F+
Sbjct: 1185 NSTSNHLWLEFNTNGSDTDQGFQLTYTSFD 1214



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 41/117 (35%), Positives = 58/117 (49%), Gaps = 5/117 (4%)

Query: 295 SAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDEC 354
           +AK   CGG + G  GT  +P +   YP+   CTW I     + I+L FH F+LE     
Sbjct: 26  AAKGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED--- 82

Query: 355 KFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
            FD + VY+       +L  R  G + P  +VS+   L + F TD  +S+ GF A Y
Sbjct: 83  -FDILSVYDGQPQQG-NLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALY 137



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 10/127 (7%)

Query: 132  QESGVSPSPQSTCGG--LLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEAL 189
            Q  G  P+ ++ C    + +G  G   SP YP  Y  +  C W I+V  ++ I + ++  
Sbjct: 2308 QFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTF 2367

Query: 190  SIESVASCLFDRLELSPEPEG--PLLRVC--GRVPPPTLNTNASHLLVVFVSDSSVEGFG 245
              E      FD LE+     G  PLL V            + ++ L + + +D +    G
Sbjct: 2368 QSEK----QFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKG 2423

Query: 246  FHAWYQA 252
            F   Y A
Sbjct: 2424 FKIRYAA 2430


>gi|7305525 low density lipoprotein-related protein 12 isoform a
           precursor [Homo sapiens]
          Length = 859

 Score =  122 bits (305), Expect = 1e-27
 Identities = 103/383 (26%), Positives = 150/383 (39%), Gaps = 73/383 (19%)

Query: 134 SGVSPSPQSTCGGL---LSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALS 190
           SGVS    + CG     +  P G  +SP +P  YP   +C W I+      I +  +   
Sbjct: 41  SGVS----TACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96

Query: 191 IESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
           I+    C  D L +         R CG   PP   ++  H+ + F SD ++   GF   Y
Sbjct: 97  IQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156

Query: 251 QAMAPGRGSCAHDEFRC----------------------DQLICL--------------- 273
            +      +CA D+FRC                      D+ IC                
Sbjct: 157 FSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCA 216

Query: 274 ----------------LPDSV-CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
                           LP+S+ CDG  +C D  DE +C      CG  L    GTF++P+
Sbjct: 217 YNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPT--CGQWLKYFYGTFNSPN 274

Query: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRF 376
           Y   YP    CTW I       + L+F +F L+       DYV++Y+        LL   
Sbjct: 275 YPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPHKLLRVL 332

Query: 377 CG--AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAG-GC 433
               +  P  +VSS  ++ V F  D   ++ GF+ATY      +  C P E+ C    GC
Sbjct: 333 TAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY----QVDGFCLPWEIPCGGNWGC 388

Query: 434 KGVQWMCDMWRDCTDGSDD-NCS 455
              Q  CD +  C +G D+ NC+
Sbjct: 389 YTEQQRCDGYWHCPNGRDETNCT 411



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 51/189 (26%), Positives = 83/189 (43%), Gaps = 12/189 (6%)

Query: 286 ADGSDETNCSAKFSGCGGN---LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQ 342
           A+ S+  + S   + CG     +    G  ++P +  +YP ++ C+W I    G  I + 
Sbjct: 32  AEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITIS 91

Query: 343 FHNFSLEAQDECKFDY--VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDH 400
           F +F ++    C  D+  +E Y+   S       R CG+  PP  +SS   + + F +D 
Sbjct: 92  FQDFDIQGSRRCNLDWLTIETYKNIESY------RACGSTIPPPYISSQDHIWIRFHSDD 145

Query: 401 GISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN-CSGPLF 459
            IS  GF   Y +  + E  C   +  C  G C    W C+   +C D SD+  C+    
Sbjct: 146 NISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEAN 205

Query: 460 PPPELACEP 468
           PP   A +P
Sbjct: 206 PPTAAAFQP 214



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 3/58 (5%)

Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNCSGPLFPPPELACEPVQVEMCLGL 477
           C P    C+   C    W+CD   DC DGSD +NC  P+  P  +    V   +  GL
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC--PVIVPTRVITAAVIGSLICGL 506



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 15/35 (42%), Positives = 17/35 (48%)

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
           C    F C    C+    VCD   +C DGSDE NC
Sbjct: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485


>gi|167555125 low density lipoprotein receptor-related protein 3
           [Homo sapiens]
          Length = 770

 Score =  121 bits (304), Expect = 2e-27
 Identities = 111/393 (28%), Positives = 142/393 (36%), Gaps = 76/393 (19%)

Query: 142 STCGGLL---SGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCL 198
           + C G L   +  RG   SP +P  YPP T+C W+IQ      I +      +E    C 
Sbjct: 41  AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100

Query: 199 FDRLELSPE--PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGF--GFHAWYQAMA 254
            D L L P   P     R+CG   PP   +   H+ + F SD+S  G   GF   Y    
Sbjct: 101 LDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK 160

Query: 255 PGRGSCAHDEFRCDQLICLL---------------------------PDSV--------- 278
            G+ SC  DEFRCD   CL                            P S+         
Sbjct: 161 LGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCS 220

Query: 279 -------------CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYL--QQYPH 323
                        CDG  +C DGSDE  C      CG  L    G+F++P      + P 
Sbjct: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGCPD--LACGRRLGSFYGSFASPDLFGAARGPS 278

Query: 324 QLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG--RFCGAEP 381
            L CTW +       + LQ     L    +   DYV+VYE        LL    +     
Sbjct: 279 DLHCTWLVDTQDSRRVLLQ---LELRLGYD---DYVQVYEGLGERGDRLLQTLSYRSNHR 332

Query: 382 PPHLVSSHHELAVLFRTDHGISSGGFSATYLAFN---ATENPCGPSELSCQAG----GCK 434
           P  L ++   L V +      +  GF+ATY         E PCG S  S        GC 
Sbjct: 333 PVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCF 392

Query: 435 GVQWMCDMWRDCTDGSDDNCSGPLFPPPELACE 467
                CD W  C  G D+    P  PP +  CE
Sbjct: 393 SEPQRCDGWWHCASGRDEQ-GCPACPPDQYPCE 424



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 43/176 (24%), Positives = 62/176 (35%), Gaps = 12/176 (6%)

Query: 130 GQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPY--PPNTHCVWHIQVATDHAIQLKIE 187
           G  E+G    P   CG  L    G F+SP+       P + HC W +       + L++E
Sbjct: 243 GSDEAGC---PDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLE 299

Query: 188 ALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFH 247
                     +++ L    +     L       P +L      L V + + +   G GF+
Sbjct: 300 LRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFN 359

Query: 248 AWYQAMA-------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSA 296
           A YQ          P   S   D        C      CDG+ +CA G DE  C A
Sbjct: 360 ATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPA 415



 Score = 37.4 bits (85), Expect = 0.038
 Identities = 16/38 (42%), Positives = 19/38 (50%)

Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSA 296
           SC    F C   +C+     CDG  +C DGSDE  C A
Sbjct: 454 SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491



 Score = 33.1 bits (74), Expect = 0.72
 Identities = 13/33 (39%), Positives = 15/33 (45%)

Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
           C P    C    C    W CD   DC DGSD++
Sbjct: 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEH 487


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  121 bits (303), Expect = 2e-27
 Identities = 87/331 (26%), Positives = 143/331 (43%), Gaps = 70/331 (21%)

Query: 155 FSSPNYPD-PYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE----LSPEPE 209
           F++P +PD PYP +  C W ++   D  + L   +  + S      D +     LSP   
Sbjct: 228 FTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEP 287

Query: 210 GPLLRVCGRVPPP---TLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFR 266
             L+++CG  PP    T +++ + LL+  ++++     GF A +  +             
Sbjct: 288 HALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLP------------ 335

Query: 267 CDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLL 326
                                         + S CGG L   QGTF++P Y   YP  + 
Sbjct: 336 ------------------------------RMSSCGGRLRKAQGTFNSPYYPGHYPPNID 365

Query: 327 CTWHISVPAGHSIELQFHNFSL----EAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPP 382
           CTW+I VP    ++++F  F L         C  DYVE+             ++CG    
Sbjct: 366 CTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGE----------KYCGERSQ 415

Query: 383 PHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDM 442
             + S+ +++ V F +D   +  GF A YL++++++ PC P + +C+ G C   +  CD 
Sbjct: 416 FVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSD-PC-PGQFTCRTGRCIRKELRCDG 473

Query: 443 WRDCTDGSDD-NCS---GPLFPPPELACEPV 469
           W DCTD SD+ NCS   G  F      C+P+
Sbjct: 474 WADCTDHSDELNCSCDAGHQFTCKNKFCKPL 504



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 12/158 (7%)

Query: 142 STCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSI----ESVASC 197
           S+CGG L   +G F+SP YP  YPPN  C W+I+V  +  ++++ +   +        +C
Sbjct: 338 SSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTC 397

Query: 198 LFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
             D +E++ E      + CG      + +N++ + V F SD S    GF A Y  ++   
Sbjct: 398 PKDYVEINGE------KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEY--LSYDS 449

Query: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCS 295
                 +F C    C+  +  CDG+A+C D SDE NCS
Sbjct: 450 SDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS 487



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 16/36 (44%), Positives = 19/36 (52%)

Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
           SC    FRC    CL     C+G  +C DGSDE +C
Sbjct: 524 SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 15/37 (40%), Positives = 22/37 (59%), Gaps = 1/37 (2%)

Query: 259 SCAHDEFRCDQLICLLPDSV-CDGFANCADGSDETNC 294
           +C    +RC   +CL   +  CDG  +C+DGSDE +C
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602


>gi|208973262 low density lipoprotein-related protein 12 isoform b
           precursor [Homo sapiens]
          Length = 840

 Score =  121 bits (303), Expect = 2e-27
 Identities = 97/366 (26%), Positives = 143/366 (39%), Gaps = 66/366 (18%)

Query: 148 LSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPE 207
           +  P G  +SP +P  YP   +C W I+      I +  +   I+    C  D L +   
Sbjct: 35  IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94

Query: 208 PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRC 267
                 R CG   PP   ++  H+ + F SD ++   GF   Y +      +CA D+FRC
Sbjct: 95  KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 154

Query: 268 ----------------------DQLICL-------------------------------L 274
                                 D+ IC                                L
Sbjct: 155 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 214

Query: 275 PDSV-CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISV 333
           P+S+ CDG  +C D  DE +C      CG  L    GTF++P+Y   YP    CTW I  
Sbjct: 215 PESLKCDGNIDCLDLGDEIDCDVPT--CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDT 272

Query: 334 PAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCG--AEPPPHLVSSHHE 391
                + L+F +F L+       DYV++Y+        LL       +  P  +VSS  +
Sbjct: 273 GDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQ 330

Query: 392 LAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAG-GCKGVQWMCDMWRDCTDGS 450
           + V F  D   ++ GF+ATY      +  C P E+ C    GC   Q  CD +  C +G 
Sbjct: 331 IRVHFCADKVNAARGFNATY----QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 386

Query: 451 DD-NCS 455
           D+ NC+
Sbjct: 387 DETNCT 392



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 46/162 (28%), Positives = 73/162 (45%), Gaps = 9/162 (5%)

Query: 310 GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY--VEVYETSSS 367
           G  ++P +  +YP ++ C+W I    G  I + F +F ++    C  D+  +E Y+   S
Sbjct: 40  GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 99

Query: 368 GAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELS 427
                  R CG+  PP  +SS   + + F +D  IS  GF   Y +  + E  C   +  
Sbjct: 100 Y------RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153

Query: 428 CQAGGCKGVQWMCDMWRDCTDGSDDN-CSGPLFPPPELACEP 468
           C  G C    W C+   +C D SD+  C+    PP   A +P
Sbjct: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 49/158 (31%), Positives = 71/158 (44%), Gaps = 9/158 (5%)

Query: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVA----SCL 198
           TCG  L    G F+SPNYPD YPP ++C W I       + L+     ++         +
Sbjct: 239 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI 298

Query: 199 FDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRG 258
           +D LE +P     +L       P T+ +++  + V F +D      GF+A YQ      G
Sbjct: 299 YDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV----DG 354

Query: 259 SCAHDEFRC-DQLICLLPDSVCDGFANCADGSDETNCS 295
            C   E  C     C      CDG+ +C +G DETNC+
Sbjct: 355 FCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT 392



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 3/58 (5%)

Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNCSGPLFPPPELACEPVQVEMCLGL 477
           C P    C+   C    W+CD   DC DGSD +NC  P+  P  +    V   +  GL
Sbjct: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC--PVIVPTRVITAAVIGSLICGL 487



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 15/35 (42%), Positives = 17/35 (48%)

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
           C    F C    C+    VCD   +C DGSDE NC
Sbjct: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466


>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
          Length = 909

 Score =  109 bits (272), Expect = 8e-24
 Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)

Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
           V   P   CGG L S   G+ +SP YP  YP + +C W +     +  I L         
Sbjct: 20  VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79

Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
              C +D +E+     E    L + CG + PPT+ ++ S L + F SD + +G GF   Y
Sbjct: 80  KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139

Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
           +    G   C+                                          N T   G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158

Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
           T  +P + ++YPH L CT+ I       I LQF  F LE       + +CK+D++++++ 
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                  L+G++CG + P  L SS   L++ F TD  ++  GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)

Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
           CGG L     G  ++P Y Q YP    C W +  P     I L F+ +F +E  D CK+D
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           ++E+ +  S  A  LLG+ CG   PP ++SS   L + F +D+     GFS  Y  F   
Sbjct: 87  FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 418 ENPC 421
              C
Sbjct: 146 SEDC 149


>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
          Length = 901

 Score =  109 bits (272), Expect = 8e-24
 Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)

Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
           V   P   CGG L S   G+ +SP YP  YP + +C W +     +  I L         
Sbjct: 20  VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79

Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
              C +D +E+     E    L + CG + PPT+ ++ S L + F SD + +G GF   Y
Sbjct: 80  KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139

Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
           +    G   C+                                          N T   G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158

Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
           T  +P + ++YPH L CT+ I       I LQF  F LE       + +CK+D++++++ 
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                  L+G++CG + P  L SS   L++ F TD  ++  GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)

Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
           CGG L     G  ++P Y Q YP    C W +  P     I L F+ +F +E  D CK+D
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           ++E+ +  S  A  LLG+ CG   PP ++SS   L + F +D+     GFS  Y  F   
Sbjct: 87  FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 418 ENPC 421
              C
Sbjct: 146 SEDC 149


>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
          Length = 931

 Score =  109 bits (272), Expect = 8e-24
 Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)

Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
           V   P   CGG L S   G+ +SP YP  YP + +C W +     +  I L         
Sbjct: 20  VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79

Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
              C +D +E+     E    L + CG + PPT+ ++ S L + F SD + +G GF   Y
Sbjct: 80  KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139

Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
           +    G   C+                                          N T   G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158

Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
           T  +P + ++YPH L CT+ I       I LQF  F LE       + +CK+D++++++ 
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                  L+G++CG + P  L SS   L++ F TD  ++  GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)

Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
           CGG L     G  ++P Y Q YP    C W +  P     I L F+ +F +E  D CK+D
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           ++E+ +  S  A  LLG+ CG   PP ++SS   L + F +D+     GFS  Y  F   
Sbjct: 87  FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 418 ENPC 421
              C
Sbjct: 146 SEDC 149


>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
          Length = 555

 Score =  109 bits (272), Expect = 8e-24
 Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)

Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
           V   P   CGG L S   G+ +SP YP  YP + +C W +     +  I L         
Sbjct: 20  VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79

Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
              C +D +E+     E    L + CG + PPT+ ++ S L + F SD + +G GF   Y
Sbjct: 80  KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139

Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
           +    G   C+                                          N T   G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158

Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
           T  +P + ++YPH L CT+ I       I LQF  F LE       + +CK+D++++++ 
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                  L+G++CG + P  L SS   L++ F TD  ++  GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)

Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
           CGG L     G  ++P Y Q YP    C W +  P     I L F+ +F +E  D CK+D
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           ++E+ +  S  A  LLG+ CG   PP ++SS   L + F +D+     GFS  Y  F   
Sbjct: 87  FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 418 ENPC 421
              C
Sbjct: 146 SEDC 149


>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
          Length = 906

 Score =  109 bits (272), Expect = 8e-24
 Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)

Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
           V   P   CGG L S   G+ +SP YP  YP + +C W +     +  I L         
Sbjct: 20  VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79

Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
              C +D +E+     E    L + CG + PPT+ ++ S L + F SD + +G GF   Y
Sbjct: 80  KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139

Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
           +    G   C+                                          N T   G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158

Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
           T  +P + ++YPH L CT+ I       I LQF  F LE       + +CK+D++++++ 
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                  L+G++CG + P  L SS   L++ F TD  ++  GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)

Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
           CGG L     G  ++P Y Q YP    C W +  P     I L F+ +F +E  D CK+D
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           ++E+ +  S  A  LLG+ CG   PP ++SS   L + F +D+     GFS  Y  F   
Sbjct: 87  FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 418 ENPC 421
              C
Sbjct: 146 SEDC 149


>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
          Length = 926

 Score =  109 bits (272), Expect = 8e-24
 Identities = 78/287 (27%), Positives = 119/287 (41%), Gaps = 53/287 (18%)

Query: 136 VSPSPQSTCGGLL-SGPRGFFSSPNYPDPYPPNTHCVWHIQVAT-DHAIQLKIEALSIES 193
           V   P   CGG L S   G+ +SP YP  YP + +C W +     +  I L         
Sbjct: 20  VRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE 79

Query: 194 VASCLFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
              C +D +E+     E    L + CG + PPT+ ++ S L + F SD + +G GF   Y
Sbjct: 80  KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139

Query: 251 QAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQG 310
           +    G   C+                                          N T   G
Sbjct: 140 EIFKTGSEDCSK-----------------------------------------NFTSPNG 158

Query: 311 TFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLE------AQDECKFDYVEVYET 364
           T  +P + ++YPH L CT+ I       I LQF  F LE       + +CK+D++++++ 
Sbjct: 159 TIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD- 217

Query: 365 SSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
                  L+G++CG + P  L SS   L++ F TD  ++  GFSA Y
Sbjct: 218 GIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 5/124 (4%)

Query: 301 CGGNLTGLQ-GTFSTPSYLQQYPHQLLCTWHISVPA-GHSIELQFH-NFSLEAQDECKFD 357
           CGG L     G  ++P Y Q YP    C W +  P     I L F+ +F +E  D CK+D
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           ++E+ +  S  A  LLG+ CG   PP ++SS   L + F +D+     GFS  Y  F   
Sbjct: 87  FIEIRDGDSESA-DLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145

Query: 418 ENPC 421
              C
Sbjct: 146 SEDC 149


>gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Homo
           sapiens]
          Length = 525

 Score =  107 bits (266), Expect = 4e-23
 Identities = 91/331 (27%), Positives = 139/331 (41%), Gaps = 43/331 (12%)

Query: 132 QESGVSPSPQSTCG-GLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKI-EAL 189
           Q  G+   P + CG  + +   G F+SPNYPD YPPN  C++ ++ A    I+L   E  
Sbjct: 33  QNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHY 92

Query: 190 SIESVASCLFDRLELSPEPEG--PLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGF 246
            IE    C FD LE+   P G  PL+ R CG   PP + +    + + F SD  +EG GF
Sbjct: 93  YIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGF 152

Query: 247 HAWYQAMAPGRGSCAHDEFRCDQLICLLPD---SVCDGFANCADGSDETNCSAKFSGCGG 303
            A Y                       +PD   +   G  N        +C  + SG  G
Sbjct: 153 RAKYS---------------------FIPDPDFTYLGGILN-----PIPDCQFELSGADG 186

Query: 304 NLTGLQGTFSTPSYLQQYPHQLL-CTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVY 362
            +   Q         +  P Q + C W I       I L+F ++ +E  +ECK ++V VY
Sbjct: 187 IVRSSQ----VEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVY 242

Query: 363 ETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCG 422
           + SSS   +L  +FC       ++ +   +  ++  D G     F   + +F   E PC 
Sbjct: 243 DGSSS-IENLKAKFCSTVANDVMLKTGIGVIRMW-ADEGSRLSRFRMLFTSF--VEPPCT 298

Query: 423 PSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
            S   C +  C     +C+  ++C    D+N
Sbjct: 299 SSTFFCHSNMCINNSLVCNGVQNCAYPWDEN 329



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 6/146 (4%)

Query: 271 ICLLPDSVCDGFANCADGSDETNCSAKF---SGCGGNL-TGLQGTFSTPSYLQQYPHQLL 326
           + L+   V +G A      D  N   K    + CG  + T   G F++P+Y   YP    
Sbjct: 12  VLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKE 71

Query: 327 CTWHISVPAGHSIELQF-HNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHL 385
           C + +       IEL F  ++ +E   EC+FD++EV +    G   L+ R+CG + PP +
Sbjct: 72  CIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEVRD-GPFGFSPLIDRYCGVKSPPLI 130

Query: 386 VSSHHELAVLFRTDHGISSGGFSATY 411
            S+   + + F +D  +   GF A Y
Sbjct: 131 RSTGRFMWIKFSSDEELEGLGFRAKY 156



 Score = 33.5 bits (75), Expect = 0.55
 Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 1/53 (1%)

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC-SAKFSGCGGNLTGLQGT 311
           C    F C   +C+    VC+G  NCA   DE +C   K +G    +T   GT
Sbjct: 297 CTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGVFEQITKTHGT 349


>gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3
           precursor [Homo sapiens]
          Length = 533

 Score =  102 bits (255), Expect = 7e-22
 Identities = 88/336 (26%), Positives = 145/336 (43%), Gaps = 37/336 (11%)

Query: 124 AAGTPKGQQESGVSPSPQST-CGGLLSGPRG-FFSSPNYPDPYPPNTHCVWHIQVATDHA 181
           +  T KG ++   S + +S  CG       G  F+SPNYP  YPP+  C++ I+ A    
Sbjct: 20  SGATKKGTEKQTTSETQKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQC 79

Query: 182 IQLKI-EALSIESVASCLFDRLELSPEPEG--PLL-RVCGRVPPPTLNTNASHLLVVFVS 237
           I+L   E  SIE    C FD +E+   P G  P++ R CG+  PP + ++   L + F +
Sbjct: 80  IELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFA 139

Query: 238 DSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
           D  +E  GF A Y             +F+   L  L P   C+     ++G  E+    K
Sbjct: 140 DGELESMGFSARY-------NFTPDPDFK--DLGALKPLPACEFEMGGSEGIVESIQIMK 190

Query: 298 FSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFD 357
                G  T  +               + C W+I  P    I L+F ++ ++  +ECK +
Sbjct: 191 ----EGKATASEA--------------VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRN 232

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           +V VY+ SSS    L  +FC       ++ +   +  ++  D G  +  F   + +F   
Sbjct: 233 FVAVYDGSSS-VEDLKAKFCSTVANDVMLRTGLGVIRMW-ADEGSRNSRFQMLFTSFQ-- 288

Query: 418 ENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
           E PC  +   C +  C     +C+  ++C    D+N
Sbjct: 289 EPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDEN 324



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 13/38 (34%), Positives = 18/38 (47%)

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
           C  + F C   +C+    VC+G  NC    DE +C  K
Sbjct: 292 CEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK 329


>gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2
           precursor [Homo sapiens]
          Length = 532

 Score =  102 bits (255), Expect = 7e-22
 Identities = 88/336 (26%), Positives = 145/336 (43%), Gaps = 37/336 (11%)

Query: 124 AAGTPKGQQESGVSPSPQST-CGGLLSGPRG-FFSSPNYPDPYPPNTHCVWHIQVATDHA 181
           +  T KG ++   S + +S  CG       G  F+SPNYP  YPP+  C++ I+ A    
Sbjct: 19  SGATKKGTEKQTTSETQKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQC 78

Query: 182 IQLKI-EALSIESVASCLFDRLELSPEPEG--PLL-RVCGRVPPPTLNTNASHLLVVFVS 237
           I+L   E  SIE    C FD +E+   P G  P++ R CG+  PP + ++   L + F +
Sbjct: 79  IELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFA 138

Query: 238 DSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
           D  +E  GF A Y             +F+   L  L P   C+     ++G  E+    K
Sbjct: 139 DGELESMGFSARY-------NFTPDPDFK--DLGALKPLPACEFEMGGSEGIVESIQIMK 189

Query: 298 FSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFD 357
                G  T  +               + C W+I  P    I L+F ++ ++  +ECK +
Sbjct: 190 ----EGKATASEA--------------VDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRN 231

Query: 358 YVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNAT 417
           +V VY+ SSS    L  +FC       ++ +   +  ++  D G  +  F   + +F   
Sbjct: 232 FVAVYDGSSS-VEDLKAKFCSTVANDVMLRTGLGVIRMW-ADEGSRNSRFQMLFTSFQ-- 287

Query: 418 ENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
           E PC  +   C +  C     +C+  ++C    D+N
Sbjct: 288 EPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDEN 323



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 13/38 (34%), Positives = 18/38 (47%)

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAK 297
           C  + F C   +C+    VC+G  NC    DE +C  K
Sbjct: 291 CEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEK 328


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 57/190 (30%), Positives = 93/190 (48%), Gaps = 37/190 (19%)

Query: 426 LSCQAGGCKGVQWMCDMWRDCTDGSD------------------------DNCSGPLFPP 461
           + C+ G C    + CD   DC DGSD                        D+C G     
Sbjct: 385 VECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCD 444

Query: 462 PELA------CEPVQVEMCLGLSYNTTAFPNIWVGMITQEE--VVEVLSGYKSLTSLPCY 513
           P  +      CEP+ +E+C+ L YN+T++PN + G  TQ+E  +    S + +L    CY
Sbjct: 445 PNNSLNNCSQCEPITLELCMNLPYNSTSYPN-YFGHRTQKEASISWESSLFPALVQTNCY 503

Query: 514 QHFRRLLCGLLVPRC-TPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEA 570
           ++     C +LVP+C    G  +PPCR++C+ ++ +C+S L ++G  WP   +C++ PE 
Sbjct: 504 KYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEE 563

Query: 571 -ADLEACAQP 579
            +D + C  P
Sbjct: 564 NSDNQTCLMP 573



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 33/100 (33%), Positives = 45/100 (45%), Gaps = 5/100 (5%)

Query: 465 ACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLL 524
           AC  +    C  L Y+ T  P + V  +   E+ + L  +  L  L CYQH     C L 
Sbjct: 138 ACMNITHSQCQMLPYHATLTPLLSV--VRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLA 195

Query: 525 VPRCTPLGSV---LPPCRSVCQEAEHQCQSGLALLGTPWP 561
            P C   G     L PCRS C+ A+  C+S L ++   WP
Sbjct: 196 FPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWP 235



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 10/68 (14%)

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
           C+   F+C    C+L    CDG A+C D SDE NC  K           +  +  PS  Q
Sbjct: 580 CSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK----------ERDLWECPSNKQ 629

Query: 320 QYPHQLLC 327
              H ++C
Sbjct: 630 CLKHTVIC 637



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 16/35 (45%), Positives = 20/35 (57%)

Query: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
           C  DE  C    C+  D  CDG A+C+D SDE +C
Sbjct: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 17/37 (45%), Positives = 20/37 (54%)

Query: 264 EFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG 300
           E RC    C+  + VCDG  +C D SDE NCS    G
Sbjct: 347 EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQG 383



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 16/36 (44%), Positives = 21/36 (58%)

Query: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
           +C+ + F C    CL    VCDG+ +C D SDE NC
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC 340



 Score = 36.2 bits (82), Expect = 0.085
 Identities = 17/37 (45%), Positives = 22/37 (59%), Gaps = 2/37 (5%)

Query: 421 CGPS-ELSCQAGGCKGVQWMCDMWRDCTDGSDD-NCS 455
           C P+ E  C  G C  ++W+CD   DC D SD+ NCS
Sbjct: 342 CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 14/30 (46%), Positives = 17/30 (56%)

Query: 272 CLLPDSVCDGFANCADGSDETNCSAKFSGC 301
           C+     CDG  +C DGSDE NCS   + C
Sbjct: 392 CIPSTFQCDGDEDCKDGSDEENCSVIQTSC 421



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 15/35 (42%), Positives = 18/35 (51%), Gaps = 1/35 (2%)

Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNC 454
           C PS   C++G C      CD   DC D SD +NC
Sbjct: 580 CSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614



 Score = 33.5 bits (75), Expect = 0.55
 Identities = 13/24 (54%), Positives = 15/24 (62%)

Query: 272 CLLPDSVCDGFANCADGSDETNCS 295
           CL    +CDGF +C D  DE NCS
Sbjct: 630 CLKHTVICDGFPDCPDYMDEKNCS 653



 Score = 30.0 bits (66), Expect = 6.1
 Identities = 18/49 (36%), Positives = 24/49 (48%), Gaps = 4/49 (8%)

Query: 415 NATENPCGPSE-LSCQAGGCKGVQWMCDMWRDCTDGSDD---NCSGPLF 459
           N  +  CG  E   C +G C   +  C+ + DC D SD+   NCS  LF
Sbjct: 263 NGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLF 311



 Score = 29.6 bits (65), Expect = 7.9
 Identities = 13/35 (37%), Positives = 17/35 (48%), Gaps = 1/35 (2%)

Query: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDD-NC 454
           C  +   C  G C     +CD + DC D SD+ NC
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC 340


>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
          Length = 609

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 70/269 (26%), Positives = 109/269 (40%), Gaps = 53/269 (19%)

Query: 153 GFFSSPNYPDPYPPNTHCVWHIQVATDHA-IQLKIEALSIESVASCLFDRLEL-SPEPEG 210
           G+ +SP YP  Y P+  C W IQ    +  I +            C +D +E+   E E 
Sbjct: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENEN 96

Query: 211 PLLR--VCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCD 268
              R   CG++ PP + ++   L + FVSD    G GF   Y+    G            
Sbjct: 97  GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRG------------ 144

Query: 269 QLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCT 328
                 P+                        C  N T   G   +P + ++YP+ L CT
Sbjct: 145 ------PE------------------------CSQNYTTPSGVIKSPGFPEKYPNSLECT 174

Query: 329 WHISVPAGHSIELQFHNFSLEAQDE------CKFDYVEVYETSSSGAFSLLGRFCGAEPP 382
           + +  P    I L+F +F LE          C++D +E+++         +GR+CG + P
Sbjct: 175 YIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWD-GFPDVGPHIGRYCGQKTP 233

Query: 383 PHLVSSHHELAVLFRTDHGISSGGFSATY 411
             + SS   L+++F TD  I+  GFSA Y
Sbjct: 234 GRIRSSSGILSMVFYTDSAIAKEGFSANY 262



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 40/108 (37%), Positives = 57/108 (52%), Gaps = 6/108 (5%)

Query: 310 GTFSTPSYLQQYPHQLLCTWHISVPAGHS-IELQFH-NFSLEAQDECKFDYVEVYE-TSS 366
           G  ++P Y   Y     C W I  P  +  I + F+ +F LE +D CK+DYVEV++  + 
Sbjct: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95

Query: 367 SGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAF 414
           +G F   G+FCG   PP +VSS   L + F +D+     GFS  Y  F
Sbjct: 96  NGHFR--GKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIF 141



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 22/165 (13%)

Query: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVAS------C 197
           C    + P G   SP +P+ YP +  C + +       I L+ E+  +E  ++      C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206

Query: 198 LFDRLEL---SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMA 254
            +DRLE+    P+    + R CG+  P  + +++  L +VF +DS++   GF A Y  + 
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266

Query: 255 PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS 299
               S   ++F+C + +         G  +    SD+   S+++S
Sbjct: 267 ----SSVSEDFKCMEAL---------GMESGEIHSDQITASSQYS 298


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.450 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,300,456
Number of Sequences: 37866
Number of extensions: 1623919
Number of successful extensions: 9158
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 6810
Number of HSP's gapped (non-prelim): 1958
length of query: 579
length of database: 18,247,518
effective HSP length: 108
effective length of query: 471
effective length of database: 14,157,990
effective search space: 6668413290
effective search space used: 6668413290
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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