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Search of human proteins with 6912478
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912478 karyopherin alpha 6 [Homo sapiens]
(536 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912478 karyopherin alpha 6 [Homo sapiens] 1060 0.0
gi|39812229 karyopherin alpha 5 [Homo sapiens] 909 0.0
gi|222144293 karyopherin alpha 1 [Homo sapiens] 868 0.0
gi|4504901 karyopherin alpha 4 [Homo sapiens] 479 e-135
gi|34485722 karyopherin alpha 3 [Homo sapiens] 467 e-131
gi|4504897 karyopherin alpha 2 [Homo sapiens] 452 e-127
gi|224589129 karyopherin 7 [Homo sapiens] 378 e-105
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 76 9e-14
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 76 9e-14
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 61 2e-09
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 49 2e-05
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 49 2e-05
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 48 3e-05
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens] 46 7e-05
gi|53829376 plakophilin 4 isoform b [Homo sapiens] 44 3e-04
gi|53829374 plakophilin 4 isoform a [Homo sapiens] 44 3e-04
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 43 8e-04
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur... 43 8e-04
gi|19923142 karyopherin beta 1 [Homo sapiens] 40 0.005
gi|207029299 NIMA-related kinase 10 isoform 3 [Homo sapiens] 40 0.007
gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens] 39 0.016
gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens] 39 0.016
gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens] 39 0.016
gi|4504811 junction plakoglobin [Homo sapiens] 38 0.020
gi|12056468 junction plakoglobin [Homo sapiens] 38 0.020
gi|23510381 transportin 1 isoform 2 [Homo sapiens] 38 0.027
gi|133925811 transportin 1 isoform 1 [Homo sapiens] 38 0.027
gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens] 38 0.027
gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens] 38 0.027
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] 38 0.027
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 1060 bits (2742), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA
Sbjct: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
Query: 61 AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 120
AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI
Sbjct: 61 AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 120
Query: 121 NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF 180
NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF
Sbjct: 121 NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF 180
Query: 181 EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRG 240
EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRG
Sbjct: 181 EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRG 240
Query: 241 KNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLV 300
KNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLV
Sbjct: 241 KNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLV 300
Query: 301 ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI 360
ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI
Sbjct: 301 ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI 360
Query: 361 SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSL 420
SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSL
Sbjct: 361 SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSL 420
Query: 421 GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIE 480
GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIE
Sbjct: 421 GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIE 480
Query: 481 FLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL 536
FLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL
Sbjct: 481 FLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL 536
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 909 bits (2348), Expect = 0.0
Identities = 453/539 (84%), Positives = 489/539 (90%), Gaps = 3/539 (0%)
Query: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
M+ MASPGKDNYRMKSYKN ALNP+EMRRRREEEGIQLRKQKRE+QLFKRRNV L +
Sbjct: 1 MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDE 60
Query: 61 AMFDSLLMDSYVSSTTG---ESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPID 117
+M +S + D +SST E V+T +MV+M+FS+++D QL TQKFRKLLSKEP+PPID
Sbjct: 61 SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID 120
Query: 118 EVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLN 177
+VI P VV RFV+FL+RNENCTLQFEAAWALTNIASGT TK+VIE GAVPIFI+LLN
Sbjct: 121 QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN 180
Query: 178 SDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNL 237
S+ EDVQEQAVWALGNIAGD++ CRD+VLNC IL PLL LLT S RLT TRNAVWALSNL
Sbjct: 181 SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL 240
Query: 238 CRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCR 297
CRGKNPPP F+KVSPCL VLSRLLFSSD D+LAD CWALSYLSDGPN+KIQAVIDSGVCR
Sbjct: 241 CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR 300
Query: 298 RLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 357
RLVELLMHNDYKV SPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC
Sbjct: 301 RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 360
Query: 358 WTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 417
WT+SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL
Sbjct: 361 WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL 420
Query: 418 VSLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLD 477
V+LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQE K++G G+NPYC LIEEAYGLD
Sbjct: 421 VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD 480
Query: 478 KIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL 536
KIEFLQSHENQEIYQKAFDLIEHYFGVE+DD S+ PQVDE QQQFIFQQ EAPM+GFQL
Sbjct: 481 KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL 539
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 868 bits (2242), Expect = 0.0
Identities = 437/538 (81%), Positives = 480/538 (89%), Gaps = 5/538 (0%)
Query: 4 MASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNV---ELINEEA 60
M +PGK+N+R+KSYKN +LNP+EMRRRREEEG+QLRKQKRE+QLFKRRNV E EE
Sbjct: 1 MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEE 60
Query: 61 AMFDSLLMDSYVSST--TGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDE 118
M D ++ +S+ VIT +M+EM+FS + QL+ TQKFRKLLSKEP+PPIDE
Sbjct: 61 VMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDE 120
Query: 119 VINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNS 178
VI+TP VV RFVEFLKR ENCTLQFE+AW LTNIASG S QT+IVI+AGAVPIFIELL+S
Sbjct: 121 VISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSS 180
Query: 179 DFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLC 238
+FEDVQEQAVWALGNIAGDS++CRDYVL+C+IL PLL L +K RLTMTRNAVWALSNLC
Sbjct: 181 EFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLC 240
Query: 239 RGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRR 298
RGK+PPPEFAKVSPCL VLS LLF SD+D+LADACWALSYLSDGPN+KIQAVID+GVCRR
Sbjct: 241 RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRR 300
Query: 299 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 358
LVELLMHNDYKV SPALRAVGNIVTGDDIQTQVILNCSAL LLHLLSSPKESI+KEACW
Sbjct: 301 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACW 360
Query: 359 TISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLV 418
TISNITAGNRAQIQ VIDANIFP LI ILQ AEFRTRKEAAWAITNATSGG+ EQI+YLV
Sbjct: 361 TISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLV 420
Query: 419 SLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDK 478
LGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQE KR+G+G+NPYC LIEEAYGLDK
Sbjct: 421 ELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDK 480
Query: 479 IEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL 536
IEFLQSHENQEIYQKAFDLIEHYFG ED+DSS+APQVD QQQ+IFQQ EAPMEGFQL
Sbjct: 481 IEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL 538
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 479 bits (1233), Expect = e-135
Identities = 253/528 (47%), Positives = 352/528 (66%), Gaps = 17/528 (3%)
Query: 10 DNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMD 69
DN R+K++KN + E MRR+R E ++LRK KR++ L KRRNV +E+ + D
Sbjct: 8 DNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVP--HEDICEDSDIDGD 65
Query: 70 SYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRF 129
V +T+ E++ V+ SD+ +QL+ Q RKLLS + +PPID++I + ++
Sbjct: 66 YRVQNTSLEAI-----VQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSG-ILPIL 119
Query: 130 VEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVW 189
V L+R++N +LQFEAAWALTNIASGTS+QT+ V+++ AVP+F+ LL+S ++V EQAVW
Sbjct: 120 VHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVW 179
Query: 190 ALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAK 249
ALGNI GD CRDYV++ ++ PLL+ ++ S +T RN W + NLCR K+PPP
Sbjct: 180 ALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMET 239
Query: 250 VSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYK 309
+ LP L L+ +D ++L D WALSYL+D NE+IQ VIDSG+ LV LL H + K
Sbjct: 240 IQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVK 299
Query: 310 VASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRA 369
V + ALRAVGNIVTG D QTQV+LNC AL LL+ PKE I KEA W +SNITAGN+
Sbjct: 300 VQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQ 359
Query: 370 QIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDL 429
Q+QAVIDAN+ P++I +L K +F T+KEAAWAI+N T G +Q+ YL+ I P C+L
Sbjct: 360 QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNL 419
Query: 430 LTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQE 489
LTV D+++VQV L+GL NIL++ E E + G+ LIEE GL+KIE LQ+HEN++
Sbjct: 420 LTVKDAQVVQVVLDGLSNILKMAEDEAETIGN-------LIEECGGLEKIEQLQNHENED 472
Query: 490 IYQKAFDLIEHYFGVE--DDDSSLAPQVDETQQQFIFQQPEAPMEGFQ 535
IY+ A+++I+ +F + D+D SL P+ + P EGFQ
Sbjct: 473 IYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQ 520
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 467 bits (1202), Expect = e-131
Identities = 247/514 (48%), Positives = 345/514 (67%), Gaps = 17/514 (3%)
Query: 6 SPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDS 65
+P +N+R+KS+KN + E MRR R E ++LRK KR++ L K+RNV +E ++ DS
Sbjct: 4 NPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVP---QEESLEDS 60
Query: 66 LLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRV 125
+ + + ++V +++ SD+ +QL+ Q RKLLS + +PPID++I + +
Sbjct: 61 DVDADFKA----QNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSG-I 115
Query: 126 VDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQE 185
+ V+ L+R++N +LQFEAAWALTNIASGTS QT+ V+++ AVP+F+ LL S ++V E
Sbjct: 116 LPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCE 175
Query: 186 QAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPP 245
QAVWALGNI GD CRDYV++ ++ PLL+ ++ S +T RN W + NLCR K+PPP
Sbjct: 176 QAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPP 235
Query: 246 EFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMH 305
V LP L L++ +D ++L D WALSYL+DG NE+IQ VIDSGV LV LL H
Sbjct: 236 PMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSH 295
Query: 306 NDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 365
+ KV + ALRAVGNIVTG D QTQV+LNC L +LLS PKE I KEA W +SNITA
Sbjct: 296 QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITA 355
Query: 366 GNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKP 425
GN+ Q+QAVIDA + P++I L K +F T+KEAAWAI+N T G +Q+ YLV I P
Sbjct: 356 GNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPP 415
Query: 426 LCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSH 485
C+LL+V DS++VQV L+GL+NIL + +G + +IEE GL+KIE LQ H
Sbjct: 416 FCNLLSVKDSQVVQVVLDGLKNILIM-------AGDEASTIAEIIEECGGLEKIEVLQQH 468
Query: 486 ENQEIYQKAFDLIEHYFGVE--DDDSSLAPQVDE 517
EN++IY+ AF++I+ YF + D+D L P+ +
Sbjct: 469 ENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQ 502
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 452 bits (1163), Expect = e-127
Identities = 252/536 (47%), Positives = 341/536 (63%), Gaps = 18/536 (3%)
Query: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
M T + R+ +KN + EMRRRR E ++LRK K++ Q+ KRRNV ++A
Sbjct: 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA 60
Query: 61 AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 120
L + T SV ++V+ + S + + QL TQ RKLLS+E PPID +I
Sbjct: 61 T--SPLQENRNNQGTVNWSV--DDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNII 116
Query: 121 NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF 180
++ +FV FL R + +QFE+AWALTNIASGTS+QTK V++ GA+P FI LL S
Sbjct: 117 RAG-LIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPH 175
Query: 181 EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLT----KSTRLTMTRNAVWALSN 236
+ EQAVWALGNIAGD SV RD V+ ++PLL LL S RN W LSN
Sbjct: 176 AHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSN 235
Query: 237 LCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVC 296
LCR KNP P V LP L RLL D ++LAD CWA+SYL+DGPNE+I V+ +GV
Sbjct: 236 LCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVV 295
Query: 297 RRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEA 356
+LV+LL ++ + +PALRA+GNIVTG D QTQV+++ AL LL++PK +I+KEA
Sbjct: 296 PQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEA 355
Query: 357 CWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRY 416
WT+SNITAG + QIQ V++ + P L+ +L KA+F+T+KEA WA+TN TSGGT EQI Y
Sbjct: 356 TWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVY 415
Query: 417 LVSLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGL 476
LV G I+PL +LLT D+KI+ V L+ + NI + E+ G+ + +IEE GL
Sbjct: 416 LVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSI-----MIEECGGL 470
Query: 477 DKIEFLQSHENQEIYQKAFDLIEHYFGV-EDDDSSLAPQVDETQQQFIFQ-QPEAP 530
DKIE LQ+HEN+ +Y+ + LIE YF V E++D ++ P+ T + + FQ Q AP
Sbjct: 471 DKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPET--TSEGYTFQVQDGAP 524
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 378 bits (970), Expect = e-105
Identities = 222/524 (42%), Positives = 316/524 (60%), Gaps = 17/524 (3%)
Query: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
M T+ +P + R + +K + R++R ++LRK K+++Q KRRN+ +
Sbjct: 1 MPTLDAPEE---RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDT 57
Query: 61 AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 120
+ VS T GE +++ + S D L TQ RK+LS+E +PP+ VI
Sbjct: 58 PS-EKTAKGVAVSLTLGE------IIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVI 110
Query: 121 NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF 180
++ R VEFLK + LQFEAAWALTNIASGTS+QT+ V+E GA+ IELL+S
Sbjct: 111 EAG-LIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSN 169
Query: 181 EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRG 240
V EQAVWALGNIAGD RD V+ + + LL L++ + +T RN W LSNLCR
Sbjct: 170 VAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRN 229
Query: 241 KNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLV 300
KNP P V LP L LL DS++L+DACWALSYL+DG N++I V+++GV RLV
Sbjct: 230 KNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLV 289
Query: 301 ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI 360
L+ ++ V +P+LR VGNIVTG D QTQ+ ++ L L LL K SI+KEA W +
Sbjct: 290 VLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWAL 349
Query: 361 SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSL 420
SN+ AG IQ ++ ++ P L+ +L+ EF+ +KEA W + N +G T +Q+ LV
Sbjct: 350 SNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHS 409
Query: 421 GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIE 480
G ++PL +LLT D KIV + L+ + IL+ E+ ++ C LIEE G+D+IE
Sbjct: 410 GVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKEN-----LCLLIEELGGIDRIE 464
Query: 481 FLQSHENQEIYQKAFDLIEHYFGVEDDDS-SLAPQVDETQQQFI 523
LQ HEN++I Q A ++IE +FG E+D+S +L QV + +FI
Sbjct: 465 ALQLHENRQIGQSALNIIEKHFGEEEDESQTLLSQVIDQDYEFI 508
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 75.9 bits (185), Expect = 9e-14
Identities = 65/275 (23%), Positives = 121/275 (44%), Gaps = 6/275 (2%)
Query: 158 QQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTL 217
Q + + AG + + LL +Q+ A ALG +A + + V+ C IL L+
Sbjct: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
Query: 218 LTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPC--LPVLSRLLFSSDSDLLADACWA 275
L + R + A + L + GK+ P + C L L L D + A WA
Sbjct: 92 LAEQNRF-YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWA 148
Query: 276 LSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNC 335
L Y++ E QAV+D+G LV + + + A A+ +I Q +++
Sbjct: 149 LRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDA 208
Query: 336 SALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTR 395
A+ L ++ +P ++ + +S ++ + + V++A IFPV++ L+ + +
Sbjct: 209 GAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVK 268
Query: 396 KEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLL 430
K A+ I TPE + +V+ G + + D +
Sbjct: 269 KNASTLIREIAK-HTPELSQLVVNAGGVAAVIDCI 302
Score = 65.9 bits (159), Expect = 9e-11
Identities = 69/312 (22%), Positives = 138/312 (44%), Gaps = 11/312 (3%)
Query: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 204
AA+ L + + Q + +++ GA+ + L V+E A WAL IA ++
Sbjct: 103 AAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQA 162
Query: 205 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV---SPCLPVLSRLL 261
V++ + PLL L + + + R A ALS++ + PE A+ + + L++++
Sbjct: 163 VVDAGAV-PLLVLCIQEPEIALKRIAASALSDIAKHS---PELAQTVVDAGAVAHLAQMI 218
Query: 262 FSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNI 321
+ D+ L ALS +S + + V+++ + ++ L D V A + I
Sbjct: 219 LNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREI 278
Query: 322 VTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFP 381
+Q+++N + ++ + S K + R + + A + AVI + P
Sbjct: 279 AKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVP 338
Query: 382 VL-IEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDL-LTVMDSKIVQ 439
L + + ++ E + AAWA+ TPE R + + L L ++ S+ +Q
Sbjct: 339 QLSVCLSEEPEDHIKAAAAWAL-GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQ 397
Query: 440 V-ALNGLENILR 450
V + ++NIL+
Sbjct: 398 VKSKKAIKNILQ 409
Score = 59.7 bits (143), Expect = 7e-09
Identities = 53/256 (20%), Positives = 104/256 (40%), Gaps = 1/256 (0%)
Query: 140 TLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSS 199
T+Q AA AL +A+ + V++ +P + L ++ A + L + S
Sbjct: 56 TIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSP 115
Query: 200 VCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSR 259
+++C L+ L+ L + + A WAL + R + + +P+L
Sbjct: 116 QLAQAIVDCGALDTLVICL-EDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVL 174
Query: 260 LLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVG 319
+ + L A ALS ++ E Q V+D+G L +++++ D K+ L A+
Sbjct: 175 CIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALS 234
Query: 320 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANI 379
+ ++++ P +L L E ++K A I I Q V++A
Sbjct: 235 QVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
Query: 380 FPVLIEILQKAEFRTR 395
+I+ + + TR
Sbjct: 295 VAAVIDCIGSCKGNTR 310
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 75.9 bits (185), Expect = 9e-14
Identities = 65/275 (23%), Positives = 121/275 (44%), Gaps = 6/275 (2%)
Query: 158 QQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTL 217
Q + + AG + + LL +Q+ A ALG +A + + V+ C IL L+
Sbjct: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
Query: 218 LTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPC--LPVLSRLLFSSDSDLLADACWA 275
L + R + A + L + GK+ P + C L L L D + A WA
Sbjct: 92 LAEQNRF-YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWA 148
Query: 276 LSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNC 335
L Y++ E QAV+D+G LV + + + A A+ +I Q +++
Sbjct: 149 LRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDA 208
Query: 336 SALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTR 395
A+ L ++ +P ++ + +S ++ + + V++A IFPV++ L+ + +
Sbjct: 209 GAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVK 268
Query: 396 KEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLL 430
K A+ I TPE + +V+ G + + D +
Sbjct: 269 KNASTLIREIAK-HTPELSQLVVNAGGVAAVIDCI 302
Score = 65.9 bits (159), Expect = 9e-11
Identities = 69/312 (22%), Positives = 138/312 (44%), Gaps = 11/312 (3%)
Query: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 204
AA+ L + + Q + +++ GA+ + L V+E A WAL IA ++
Sbjct: 103 AAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQA 162
Query: 205 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV---SPCLPVLSRLL 261
V++ + PLL L + + + R A ALS++ + PE A+ + + L++++
Sbjct: 163 VVDAGAV-PLLVLCIQEPEIALKRIAASALSDIAKHS---PELAQTVVDAGAVAHLAQMI 218
Query: 262 FSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNI 321
+ D+ L ALS +S + + V+++ + ++ L D V A + I
Sbjct: 219 LNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREI 278
Query: 322 VTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFP 381
+Q+++N + ++ + S K + R + + A + AVI + P
Sbjct: 279 AKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVP 338
Query: 382 VL-IEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDL-LTVMDSKIVQ 439
L + + ++ E + AAWA+ TPE R + + L L ++ S+ +Q
Sbjct: 339 QLSVCLSEEPEDHIKAAAAWAL-GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQ 397
Query: 440 V-ALNGLENILR 450
V + ++NIL+
Sbjct: 398 VKSKKAIKNILQ 409
Score = 59.7 bits (143), Expect = 7e-09
Identities = 53/256 (20%), Positives = 104/256 (40%), Gaps = 1/256 (0%)
Query: 140 TLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSS 199
T+Q AA AL +A+ + V++ +P + L ++ A + L + S
Sbjct: 56 TIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSP 115
Query: 200 VCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSR 259
+++C L+ L+ L + + A WAL + R + + +P+L
Sbjct: 116 QLAQAIVDCGALDTLVICL-EDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVL 174
Query: 260 LLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVG 319
+ + L A ALS ++ E Q V+D+G L +++++ D K+ L A+
Sbjct: 175 CIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALS 234
Query: 320 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANI 379
+ ++++ P +L L E ++K A I I Q V++A
Sbjct: 235 QVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
Query: 380 FPVLIEILQKAEFRTR 395
+I+ + + TR
Sbjct: 295 VAAVIDCIGSCKGNTR 310
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 61.2 bits (147), Expect = 2e-09
Identities = 92/390 (23%), Positives = 159/390 (40%), Gaps = 42/390 (10%)
Query: 25 EEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITRE 84
EE+RRRR E LRK +REQQL +R + E A + V++ GE+ + +
Sbjct: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEA------GEGCVAAILGETEVQQF 70
Query: 85 MVE-MLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQF 143
+ + +++ + + A R L E + + R + V L N+ LQ
Sbjct: 71 LRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTL---VGLLTSNQ-ALLQL 126
Query: 144 EAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRD 203
EAA L + S + Q T A + L+S D E ++ LGN+ +S R
Sbjct: 127 EAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRR 185
Query: 204 YVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEF--AKVSPCLPVLSRLL 261
+L I+ P L +S + + +ALS L + + P + + ++ LP +
Sbjct: 186 QLLPQGIV-PALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQM 244
Query: 262 FSSDSDL----LADACWALSYL--SDGPNEKIQAVIDSGVCRRLVELLMHNDYKV----- 310
L + W L Y+ S N +I G L LL+ V
Sbjct: 245 LQPGPKLNPGVAVEFAWCLHYIICSQVSN---PLLIGHGALSTLGLLLLDLAGAVQKTED 301
Query: 311 ------ASPALRAVGNIVT-------GDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 357
A P LR + N++T G +Q + +AL LL + S+ E
Sbjct: 302 AGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEGL 361
Query: 358 WTISNITAGNRAQIQAVIDANIFPVLIEIL 387
W ++N+TA + + +++ ++ L+++L
Sbjct: 362 WLLNNLTANSPSFCTSLLSLDLIEPLLQLL 391
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/285 (21%), Positives = 118/285 (41%), Gaps = 21/285 (7%)
Query: 118 EVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLN 177
E I ++ F L +C + + A + +A + V +AG + ++LLN
Sbjct: 43 EKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPLVQLLN 99
Query: 178 SDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLL-TKSTRLTMTRNAVWALSN 236
S ++V Q ALGNI DS + ++N ++ L+ LL +T + A N
Sbjct: 100 SKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGN 159
Query: 237 LCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVC 296
L ++ +FA + ++ + D L+ L++ K+Q ++++G+
Sbjct: 160 LAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQ-LVEAGLV 218
Query: 297 RRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCL------------LHL 344
L+E++ KV S + + TG D+ ++L ++ L L
Sbjct: 219 ECLLEIVQQ---KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSW 275
Query: 345 LSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQK 389
+ S ++ I+N A N A ++D I L+++L +
Sbjct: 276 IPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLLDR 319
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/285 (21%), Positives = 118/285 (41%), Gaps = 21/285 (7%)
Query: 118 EVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLN 177
E I ++ F L +C + + A + +A + V +AG + ++LLN
Sbjct: 44 EKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPLVQLLN 100
Query: 178 SDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLL-TKSTRLTMTRNAVWALSN 236
S ++V Q ALGNI DS + ++N ++ L+ LL +T + A N
Sbjct: 101 SKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGN 160
Query: 237 LCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVC 296
L ++ +FA + ++ + D L+ L++ K+Q ++++G+
Sbjct: 161 LAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQ-LVEAGLV 219
Query: 297 RRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCL------------LHL 344
L+E++ KV S + + TG D+ ++L ++ L L
Sbjct: 220 ECLLEIVQQ---KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSW 276
Query: 345 LSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQK 389
+ S ++ I+N A N A ++D I L+++L +
Sbjct: 277 IPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLLDR 320
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 47.8 bits (112), Expect = 3e-05
Identities = 73/334 (21%), Positives = 144/334 (43%), Gaps = 19/334 (5%)
Query: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 204
A +L I Q + +++AG +P I LL S +Q + V L NI+ S
Sbjct: 649 AVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHAL 708
Query: 205 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSS 264
V + L+ LL +R AV L ++ + +N AK + +P L LL +
Sbjct: 709 V-EAGGIPSLINLLVCDEPEVHSRCAV-ILYDIAQCEN-KDVIAKYNG-IPSLINLLNLN 764
Query: 265 DSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHND---YKVASPALRAVGNI 321
++L + + L G +AV + L+ L + V+S A+ VG
Sbjct: 765 IENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGR- 823
Query: 322 VTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFP 381
+IQ + + A+P L+ L + S++ + + ++ + N +A ++ ++
Sbjct: 824 -DNKEIQDAIAME-GAIPPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTK 881
Query: 382 VLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVA 441
L+++L+ + +++ A A+ A +G T +Q +Y+ + ++L +K+ V
Sbjct: 882 YLLKLLKAFQIDVKEQGAVALW-ALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYV- 939
Query: 442 LNGLENILRLGE-----QEGKRSGSGVNPYCGLI 470
G E ++ L + Q G+G+ P L+
Sbjct: 940 --GGEAVIALSKDSRMHQNQICEGNGIAPLVRLL 971
Score = 44.3 bits (103), Expect = 3e-04
Identities = 27/93 (29%), Positives = 51/93 (54%), Gaps = 1/93 (1%)
Query: 295 VCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRK 354
V + LVE+L YK A+ ++ I +D + IL+ +P L++LL S K ++
Sbjct: 630 VWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQC 689
Query: 355 EACWTISNITAGNRAQIQAVIDANIFPVLIEIL 387
+ +SNI+ +++ + A+++A P LI +L
Sbjct: 690 KTVGLLSNIST-HKSAVHALVEAGGIPSLINLL 721
Score = 42.4 bits (98), Expect = 0.001
Identities = 64/313 (20%), Positives = 131/313 (41%), Gaps = 31/313 (9%)
Query: 91 SDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALT 150
S DSD+ A + + ++ + I + I + V K + ++Q + A A+
Sbjct: 804 SSDSDVLKAVSSAAIAEVGRD-NKEIQDAIAMEGAIPPLVALFK-GKQISVQMKGAMAVE 861
Query: 151 NIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLN--- 207
++AS + K +E ++LL + DV+EQ AL +AG + + Y+
Sbjct: 862 SLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIG 921
Query: 208 -CSILNPLLTLLTK------STRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRL 260
I+N LL+ K + +++++ + +C G P L L R+
Sbjct: 922 YSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAP--------LVRLLRI 973
Query: 261 LFSSDSDLLA------DACWALSYLSDGPNEKIQAVIDSGVCRRLVELLM-HNDYKVASP 313
++ LL+ C +++ S+ ++ Q V+D L++LL H +
Sbjct: 974 STIAEGTLLSVIRAVGSICIGVAHTSNPVSQ--QFVVDENAFPVLIQLLRNHPSPNIKVE 1031
Query: 314 ALRAVGNIVTGDDIQTQVILNCSALPC--LLHLLSSPKESIRKEACWTISNITAGNRAQI 371
++ IV G+D+ + + +L+LL S ++ I A + ++ NR Q
Sbjct: 1032 VAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNNRFQQ 1091
Query: 372 QAVIDANIFPVLI 384
++++ I + I
Sbjct: 1092 YLILESGIMTISI 1104
Score = 33.9 bits (76), Expect = 0.38
Identities = 47/241 (19%), Positives = 94/241 (39%), Gaps = 8/241 (3%)
Query: 155 GTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPL 214
G + V E +P I L+SD + ++ + A+ + D+ +D + + PL
Sbjct: 782 GNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPL 841
Query: 215 LTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 274
+ L K ++++ A+ +L + L +LL + D+
Sbjct: 842 VALF-KGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAV 900
Query: 275 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILN 334
AL L+ ++ + + + ++ +L+ K+ AV + + I
Sbjct: 901 ALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICE 960
Query: 335 CSALPCLLHLL--SSPKESIRKEACWTISNITAG-----NRAQIQAVIDANIFPVLIEIL 387
+ + L+ LL S+ E + +I G N Q V+D N FPVLI++L
Sbjct: 961 GNGIAPLVRLLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLL 1020
Query: 388 Q 388
+
Sbjct: 1021 R 1021
Score = 30.4 bits (67), Expect = 4.2
Identities = 24/108 (22%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 333 LNCSALPC---LLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQK 389
LN LP L+ +L R A ++ I N + ++DA P LI +L+
Sbjct: 623 LNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKS 682
Query: 390 AEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKI 437
++ + + + ++N ++ + LV G I L +LL + ++
Sbjct: 683 SKIKLQCKTVGLLSNIST--HKSAVHALVEAGGIPSLINLLVCDEPEV 728
>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
Length = 1992
Score = 46.2 bits (108), Expect = 7e-05
Identities = 61/267 (22%), Positives = 109/267 (40%), Gaps = 18/267 (6%)
Query: 76 TGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKR 135
+G S +++++ L + D QL + +LL + VV + L+
Sbjct: 433 SGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGG-FPVKSVVPALITLLQM 491
Query: 136 NENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNS-DFEDVQEQAVWALGNI 194
N + A ALT + + + +V++A +P+F+E L DV EQA+ AL +
Sbjct: 492 EHNFDIMNHACRALTYMMEALPRSSAVVVDA--IPVFLEKLQVIQCIDVAEQALTALEML 549
Query: 195 AGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCL 254
+ S +L L L L + + RNA+ +N C+ P EF V+ L
Sbjct: 550 SRRHSKA---ILQAGGLADCLLYL-EFFSINAQRNALAIAANCCQSITPD-EFHFVADSL 604
Query: 255 PVLSRLLFSSDSDLLADACWALSYLSDG---PNEKIQAVIDSGVCRRLVELLMHNDYKVA 311
P+L++ L D + C + L D +Q V + + +LL V
Sbjct: 605 PLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLL------VV 658
Query: 312 SPALRAVGNIVTGDDIQTQVILNCSAL 338
+P + + G + + + + NC L
Sbjct: 659 TPPILSSGMFIMVVRMFSLMCSNCPTL 685
>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
Length = 1149
Score = 44.3 bits (103), Expect = 3e-04
Identities = 39/137 (28%), Positives = 61/137 (44%), Gaps = 3/137 (2%)
Query: 244 PPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELL 303
P EFA P LP + +L + A+A L +L G N+ V G + LV+LL
Sbjct: 520 PREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLL 579
Query: 304 MHNDYKVASPALRAVGNIVTGDDIQTQVIL--NCSALPCLLHLL-SSPKESIRKEACWTI 360
H +V A A+ N+V G I N +P LL LL S +R+ +
Sbjct: 580 DHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVL 639
Query: 361 SNITAGNRAQIQAVIDA 377
N+++ + ++ + DA
Sbjct: 640 WNLSSCDAVKMTIIRDA 656
Score = 31.6 bits (70), Expect = 1.9
Identities = 48/214 (22%), Positives = 82/214 (38%), Gaps = 43/214 (20%)
Query: 113 SPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEA----GA 168
SP E++ P VV ++ L + N +A +L N+++G + + A
Sbjct: 814 SPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKG 873
Query: 169 VPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTR 228
+PI +ELL D + V AL N+A D V N ++ +
Sbjct: 874 LPILVELLRMDNDRVVSSVATALRNMALD-------VRNKELIG---------------K 911
Query: 229 NAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQ 288
A+ L N G N P VLS + +A C AL ++ E +
Sbjct: 912 YAMRDLVNRLPGGNGP----------SVLS-------DETMAAICCALHEVTSKNMENAK 954
Query: 289 AVIDSGVCRRLVELLMHNDYKVASPALRAVGNIV 322
A+ DSG +LV + + + ++A ++
Sbjct: 955 ALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVL 988
Score = 31.2 bits (69), Expect = 2.5
Identities = 19/94 (20%), Positives = 40/94 (42%), Gaps = 2/94 (2%)
Query: 299 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 358
++ +L H V + A + ++ GD+ + + L+ LL ++K AC
Sbjct: 533 VIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACG 592
Query: 359 TISNITAGNRAQIQAVIDANI--FPVLIEILQKA 390
+ N+ G + N+ P L+ +L+K+
Sbjct: 593 ALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS 626
>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
Length = 1192
Score = 44.3 bits (103), Expect = 3e-04
Identities = 39/137 (28%), Positives = 61/137 (44%), Gaps = 3/137 (2%)
Query: 244 PPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELL 303
P EFA P LP + +L + A+A L +L G N+ V G + LV+LL
Sbjct: 520 PREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLL 579
Query: 304 MHNDYKVASPALRAVGNIVTGDDIQTQVIL--NCSALPCLLHLL-SSPKESIRKEACWTI 360
H +V A A+ N+V G I N +P LL LL S +R+ +
Sbjct: 580 DHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVL 639
Query: 361 SNITAGNRAQIQAVIDA 377
N+++ + ++ + DA
Sbjct: 640 WNLSSCDAVKMTIIRDA 656
Score = 31.6 bits (70), Expect = 1.9
Identities = 48/214 (22%), Positives = 82/214 (38%), Gaps = 43/214 (20%)
Query: 113 SPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEA----GA 168
SP E++ P VV ++ L + N +A +L N+++G + + A
Sbjct: 814 SPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKG 873
Query: 169 VPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTR 228
+PI +ELL D + V AL N+A D V N ++ +
Sbjct: 874 LPILVELLRMDNDRVVSSVATALRNMALD-------VRNKELIG---------------K 911
Query: 229 NAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQ 288
A+ L N G N P VLS + +A C AL ++ E +
Sbjct: 912 YAMRDLVNRLPGGNGP----------SVLS-------DETMAAICCALHEVTSKNMENAK 954
Query: 289 AVIDSGVCRRLVELLMHNDYKVASPALRAVGNIV 322
A+ DSG +LV + + + ++A ++
Sbjct: 955 ALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVL 988
Score = 31.2 bits (69), Expect = 2.5
Identities = 19/94 (20%), Positives = 40/94 (42%), Gaps = 2/94 (2%)
Query: 299 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 358
++ +L H V + A + ++ GD+ + + L+ LL ++K AC
Sbjct: 533 VIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACG 592
Query: 359 TISNITAGNRAQIQAVIDANI--FPVLIEILQKA 390
+ N+ G + N+ P L+ +L+K+
Sbjct: 593 ALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKS 626
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 42.7 bits (99), Expect = 8e-04
Identities = 55/242 (22%), Positives = 101/242 (41%), Gaps = 6/242 (2%)
Query: 162 IVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKS 221
++IE+ + +LNS E++ +A A+ A + +L + PL LLT
Sbjct: 20 LMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHE 79
Query: 222 TRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSD 281
++ + RNA L + ++ V+++L + + A L+ +S
Sbjct: 80 DKI-VRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSA 138
Query: 282 GPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVIL-NCSALPC 340
K+Q + + G L+ LL D V ++ + N+V D Q + L +A+P
Sbjct: 139 EYTSKVQ-IFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLV--QDFQCRAKLQELNAIPP 195
Query: 341 LLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAW 400
+L LL S I+ A T+ + A ++ + D LI+IL+ E A
Sbjct: 196 ILDLLKSEYPVIQLLALKTL-GVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEAL 254
Query: 401 AI 402
A+
Sbjct: 255 AV 256
Score = 42.7 bits (99), Expect = 8e-04
Identities = 58/262 (22%), Positives = 119/262 (45%), Gaps = 24/262 (9%)
Query: 260 LLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVG 319
+L S + ++LA AC A+ + E +++ G L +LL H D V A G
Sbjct: 33 MLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFG 92
Query: 320 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKE-ACWTISNITAGNRAQIQAVIDAN 378
+ + +D++ +++ + ++ L+ +E + E A ++N++A +++Q
Sbjct: 93 ILASNNDVK-KLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGG 151
Query: 379 IFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIR-YLVSLGCIKPLCDLLTVMDSKI 437
+ P LI +L + +K + I N Q R L L I P+ DLL S+
Sbjct: 152 LEP-LIRLLSSPDPDVKKNSMECIYNLVQ---DFQCRAKLQELNAIPPILDLL---KSEY 204
Query: 438 VQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDK-IEFLQSHENQEIYQKAFD 496
+ L L+ + + + R+ ++ + GLD I+ L++ E +++ +A
Sbjct: 205 PVIQLLALKTLGVIANDKESRT---------MLRDNQGLDHLIKILETKELNDLHIEALA 255
Query: 497 LIEHYFGVEDDDSSLAPQVDET 518
+I + +ED D+ + Q+ +T
Sbjct: 256 VIANC--LEDMDTMV--QIQQT 273
Score = 42.4 bits (98), Expect = 0.001
Identities = 57/277 (20%), Positives = 103/277 (37%), Gaps = 6/277 (2%)
Query: 126 VDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQE 185
+D ++ L+ E L EA + N +I G + NS D+Q+
Sbjct: 234 LDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQK 293
Query: 186 QAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPP 245
A A+ A D R + L+ LL T A A+S +C
Sbjct: 294 NAAKAITKAAYDPEN-RKLFHEQEVEKCLVALLGSENDGTKIA-ASQAISAMCENSGSKD 351
Query: 246 EFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMH 305
F +P L +LL S + ++ A AL+ L+ A ++ L+ LL
Sbjct: 352 FFNNQG--IPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSS 409
Query: 306 NDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITA 365
+ A + N+ + ++ I N + ++ L S ++ +A ++
Sbjct: 410 KRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAIISPLRSANTVVQSKAALAVTATAC 468
Query: 366 GNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAI 402
A+ + + P L+E+L+ RK A+WA+
Sbjct: 469 DVEARTELRNSGGLEP-LVELLRSKNDEVRKHASWAV 504
Score = 42.4 bits (98), Expect = 0.001
Identities = 59/260 (22%), Positives = 107/260 (41%), Gaps = 9/260 (3%)
Query: 128 RFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQA 187
+ + F + + +Q AA A+T A+ + K+ E + LL S+ + + A
Sbjct: 278 KLLSFAENSTIPDIQKNAAKAITK-AAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAA 336
Query: 188 VWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEF 247
A+ + ++S +D+ N I P L L KS + A AL+NL
Sbjct: 337 SQAISAMC-ENSGSKDFFNNQGI--PQLIQLLKSDNEEVREAAALALANLTTCNPANANA 393
Query: 248 AKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHND 307
A + + L LL S +A+A L+ ++ ++ + + + ++ L +
Sbjct: 394 AAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLN-IQNHDIMHAIISPLRSAN 452
Query: 308 YKVASPALRAVGNIVTGDDIQTQVIL-NCSALPCLLHLLSSPKESIRKEACWTISNITAG 366
V S A AV T D++ + L N L L+ LL S + +RK A W + + AG
Sbjct: 453 TVVQSKAALAV--TATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVM-VCAG 509
Query: 367 NRAQIQAVIDANIFPVLIEI 386
+ + +L E+
Sbjct: 510 DELTANELCRLGALDILEEV 529
Score = 42.0 bits (97), Expect = 0.001
Identities = 54/236 (22%), Positives = 105/236 (44%), Gaps = 6/236 (2%)
Query: 106 KLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIE 165
K ++K P + + + V++ + L +EN + A+ A++ + + +K
Sbjct: 297 KAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSG--SKDFFN 354
Query: 166 AGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLT 225
+P I+LL SD E+V+E A AL N+ + + ++PL+ LL+ S R
Sbjct: 355 NQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLS-SKRDG 413
Query: 226 MTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNE 285
NA L+N+ + P + + + L S+++ + + A A++ +
Sbjct: 414 AIANAATVLTNMAM-QEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEA 472
Query: 286 KIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCL 341
+ + + +SG LVELL + +V A AV + GD++ + AL L
Sbjct: 473 RTE-LRNSGGLEPLVELLRSKNDEVRKHASWAV-MVCAGDELTANELCRLGALDIL 526
>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
plakophilin-related arm-repeat protein) [Homo sapiens]
Length = 1225
Score = 42.7 bits (99), Expect = 8e-04
Identities = 62/261 (23%), Positives = 103/261 (39%), Gaps = 27/261 (10%)
Query: 244 PPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELL 303
P EF P LP + ++L + ++A L +L G N+ + G + LV+LL
Sbjct: 542 PREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLL 601
Query: 304 MHNDYKVASPALRAVGNIVTG--DDIQTQVILNCSALPCLLHLLSSPKESIRKE----AC 357
H +V A A+ N+V G +D + NC +P L+ LL + +E
Sbjct: 602 DHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVL 661
Query: 358 WTISNITAGNRAQIQAVIDANIFPVLI-------------EILQKAEFRTRKEAAWAITN 404
W +S+ A IQ + V+I +Q + + A + N
Sbjct: 662 WNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRN 721
Query: 405 ATSGGTPEQIRYLVSLGCIKPLCDLL------TVMDSKIVQVALNGLENI-LRLGEQEGK 457
+S G + R G L ++ + +DSK V+ + L N+ RL + +
Sbjct: 722 VSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQ 781
Query: 458 RSGSGVNPYCGLI-EEAYGLD 477
G + GL+ EA G D
Sbjct: 782 GQHMGTDELDGLLCGEANGKD 802
Score = 30.0 bits (66), Expect = 5.5
Identities = 26/80 (32%), Positives = 37/80 (46%), Gaps = 6/80 (7%)
Query: 123 PRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGA-----VPIFIELLN 177
P +V ++ L N AA AL N+A+G S + + I A +PI +ELL
Sbjct: 844 PSIVKPYLTLLSECSNPDTLEGAAGALQNLAAG-SWKWSVYIRAAVRKEKGLPILVELLR 902
Query: 178 SDFEDVQEQAVWALGNIAGD 197
D + V AL N+A D
Sbjct: 903 IDNDRVVCAVATALRNMALD 922
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 40.0 bits (92), Expect = 0.005
Identities = 31/105 (29%), Positives = 46/105 (43%), Gaps = 2/105 (1%)
Query: 301 ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI 360
E + + D++ A+ A G I+ G + L A+P L+ L+ P +R A WT+
Sbjct: 373 EHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTV 432
Query: 361 SNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 404
I A I V A + LIE L AE R WA ++
Sbjct: 433 GRICELLPEAAINDVYLAPLLQCLIEGL-SAEPRVASNVCWAFSS 476
Score = 34.3 bits (77), Expect = 0.29
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 125 VVDRFVEFLK---RNENCTLQFEAAWALTNIASGT--SQQTKIVIEAGAVPIFIELLNSD 179
+V + F+K +N + + A A I G SQ +VI+A +P IEL+
Sbjct: 363 IVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQA--MPTLIELMKDP 420
Query: 180 FEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTK--STRLTMTRNAVWALSNL 237
V++ A W +G I + + +N L PLL L + S + N WA S+L
Sbjct: 421 SVVVRDTAAWTVGRIC---ELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSL 477
>gi|207029299 NIMA-related kinase 10 isoform 3 [Homo sapiens]
Length = 712
Score = 39.7 bits (91), Expect = 0.007
Identities = 38/150 (25%), Positives = 68/150 (45%), Gaps = 4/150 (2%)
Query: 154 SGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNP 213
+ Q + V +GA + LL + +V ++ AL ++A +S CR+ + +I+
Sbjct: 196 AAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLA-ESQECREKISELNIVEN 254
Query: 214 LLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADAC 273
LL +L + L+ A L L + E K+ +PVL LL S LL
Sbjct: 255 LLMILHEYDLLSKRLTA--ELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIV 312
Query: 274 WALSYLSDGPNEKIQAVIDSGVCRRLVELL 303
W L + + P ++ I G+ ++L+ +L
Sbjct: 313 WILVQVCEDPETSVEIRIWGGI-KQLLHIL 341
>gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 38.5 bits (88), Expect = 0.016
Identities = 35/138 (25%), Positives = 66/138 (47%), Gaps = 15/138 (10%)
Query: 99 ATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQ 158
A + R+ + K SP D+ + +P+ + + + ++ +E + A AL N A+
Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155
Query: 159 QTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGD-----------SSVCRDYV-- 205
+ I+ + G +PI ++LN+ V+E+A+ L N++ + + VC D +
Sbjct: 156 RD-IIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITS 214
Query: 206 -LNCSILNPLLTLLTKST 222
LN S+ L LLT T
Sbjct: 215 RLNSSVQLAGLRLLTNMT 232
>gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 38.5 bits (88), Expect = 0.016
Identities = 35/138 (25%), Positives = 66/138 (47%), Gaps = 15/138 (10%)
Query: 99 ATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQ 158
A + R+ + K SP D+ + +P+ + + + ++ +E + A AL N A+
Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155
Query: 159 QTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGD-----------SSVCRDYV-- 205
+ I+ + G +PI ++LN+ V+E+A+ L N++ + + VC D +
Sbjct: 156 RD-IIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITS 214
Query: 206 -LNCSILNPLLTLLTKST 222
LN S+ L LLT T
Sbjct: 215 RLNSSVQLAGLRLLTNMT 232
>gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 38.5 bits (88), Expect = 0.016
Identities = 35/138 (25%), Positives = 66/138 (47%), Gaps = 15/138 (10%)
Query: 99 ATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQ 158
A + R+ + K SP D+ + +P+ + + + ++ +E + A AL N A+
Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155
Query: 159 QTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGD-----------SSVCRDYV-- 205
+ I+ + G +PI ++LN+ V+E+A+ L N++ + + VC D +
Sbjct: 156 RD-IIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITS 214
Query: 206 -LNCSILNPLLTLLTKST 222
LN S+ L LLT T
Sbjct: 215 RLNSSVQLAGLRLLTNMT 232
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 38.1 bits (87), Expect = 0.020
Identities = 77/365 (21%), Positives = 139/365 (38%), Gaps = 32/365 (8%)
Query: 32 EEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFS 91
E + L++ QL K V LIN Y + E+ ++L
Sbjct: 107 EGQATNLQRLAEPSQLLKSAIVHLIN-------------YQDDAELATRALPELTKLLND 153
Query: 92 DDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTN 151
+D + +L KE S ++ +P++V V ++ T + A T+
Sbjct: 154 EDPVVVTKAAMIVNQLSKKEASRRA--LMGSPQLVAAVVRTMQN----TSDLDTARCTTS 207
Query: 152 IASGTSQQTK---IVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNC 208
I S + + ++G +P + +L+S E V A+ L N+ + V
Sbjct: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
Query: 209 SILNPLLTLLTKSTR--LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFS-SD 265
L ++ LL K+ L +T + L L G + L +++ + S
Sbjct: 268 DGLQKMVPLLNKNNPKFLAITTDC---LQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
Query: 266 SDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGD 325
LL L LS P+ K A++++G + L + L N ++ L + N+
Sbjct: 325 EKLLWTTSRVLKVLSVCPSNK-PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL---S 380
Query: 326 DIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIE 385
D+ T+ S L L++ LS ++ A T+SN+T N V + LI
Sbjct: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIH 440
Query: 386 ILQKA 390
+ +A
Sbjct: 441 AILRA 445
Score = 31.2 bits (69), Expect = 2.5
Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 163 VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKST 222
+ +P+F++LL S E++Q A L +A D D + PL+ LL
Sbjct: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAA-DAIDAEGASAPLMELLHSRN 638
Query: 223 RLTMTRNAVWALSNLCRGKNP 243
T T A L + KNP
Sbjct: 639 EGTATYAAA-VLFRISEDKNP 658
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 38.1 bits (87), Expect = 0.020
Identities = 77/365 (21%), Positives = 139/365 (38%), Gaps = 32/365 (8%)
Query: 32 EEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFS 91
E + L++ QL K V LIN Y + E+ ++L
Sbjct: 107 EGQATNLQRLAEPSQLLKSAIVHLIN-------------YQDDAELATRALPELTKLLND 153
Query: 92 DDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTN 151
+D + +L KE S ++ +P++V V ++ T + A T+
Sbjct: 154 EDPVVVTKAAMIVNQLSKKEASRRA--LMGSPQLVAAVVRTMQN----TSDLDTARCTTS 207
Query: 152 IASGTSQQTK---IVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNC 208
I S + + ++G +P + +L+S E V A+ L N+ + V
Sbjct: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
Query: 209 SILNPLLTLLTKSTR--LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFS-SD 265
L ++ LL K+ L +T + L L G + L +++ + S
Sbjct: 268 DGLQKMVPLLNKNNPKFLAITTDC---LQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
Query: 266 SDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGD 325
LL L LS P+ K A++++G + L + L N ++ L + N+
Sbjct: 325 EKLLWTTSRVLKVLSVCPSNK-PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL---S 380
Query: 326 DIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIE 385
D+ T+ S L L++ LS ++ A T+SN+T N V + LI
Sbjct: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIH 440
Query: 386 ILQKA 390
+ +A
Sbjct: 441 AILRA 445
Score = 31.2 bits (69), Expect = 2.5
Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 163 VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKST 222
+ +P+F++LL S E++Q A L +A D D + PL+ LL
Sbjct: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAA-DAIDAEGASAPLMELLHSRN 638
Query: 223 RLTMTRNAVWALSNLCRGKNP 243
T T A L + KNP
Sbjct: 639 EGTATYAAA-VLFRISEDKNP 658
>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
Length = 890
Score = 37.7 bits (86), Expect = 0.027
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 299 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 358
L ELL H+++ V + +G I G +Q + +P L+ LS K +R CW
Sbjct: 402 LKELLFHHEWVVKESGILVLGAIAEGC-MQGMIPYLPELIPHLIQCLSDKKALVRSITCW 460
Query: 359 TISNITAGNRAQIQAVIDANIFPVLIEILQK---AEFRTRKEAAWAITNATSGGTPEQIR 415
T+S + D + P++ E+L++ + R ++ A A E +
Sbjct: 461 TLSRYA---HWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVP 517
Query: 416 YL 417
YL
Sbjct: 518 YL 519
>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
Length = 898
Score = 37.7 bits (86), Expect = 0.027
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 299 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 358
L ELL H+++ V + +G I G +Q + +P L+ LS K +R CW
Sbjct: 410 LKELLFHHEWVVKESGILVLGAIAEGC-MQGMIPYLPELIPHLIQCLSDKKALVRSITCW 468
Query: 359 TISNITAGNRAQIQAVIDANIFPVLIEILQK---AEFRTRKEAAWAITNATSGGTPEQIR 415
T+S + D + P++ E+L++ + R ++ A A E +
Sbjct: 469 TLSRYA---HWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVP 525
Query: 416 YL 417
YL
Sbjct: 526 YL 527
>gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]
Length = 385
Score = 37.7 bits (86), Expect = 0.027
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 6/164 (3%)
Query: 282 GPNEKIQAVIDSGVCRRLVELLMH--NDYKVASPALRAVGNIVTGDDIQTQVILNCSALP 339
G N++ +I G RL+ LL + ++ + +G++ G + + +L+C +P
Sbjct: 35 GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
Query: 340 CLLHLLSSPKESIRKEACWTISNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEA 398
LL L SP + + I T+ + DA + P L+ +L ++ + T++
Sbjct: 95 ALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYI 153
Query: 399 AWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVAL 442
++ G P+ L + G ++ + LLT + K+ AL
Sbjct: 154 CQIFSHCCKG--PDHQTILFNHGAVQNIAHLLTSLSYKVRMQAL 195
>gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]
Length = 385
Score = 37.7 bits (86), Expect = 0.027
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 6/164 (3%)
Query: 282 GPNEKIQAVIDSGVCRRLVELLMH--NDYKVASPALRAVGNIVTGDDIQTQVILNCSALP 339
G N++ +I G RL+ LL + ++ + +G++ G + + +L+C +P
Sbjct: 35 GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
Query: 340 CLLHLLSSPKESIRKEACWTISNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEA 398
LL L SP + + I T+ + DA + P L+ +L ++ + T++
Sbjct: 95 ALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYI 153
Query: 399 AWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVAL 442
++ G P+ L + G ++ + LLT + K+ AL
Sbjct: 154 CQIFSHCCKG--PDHQTILFNHGAVQNIAHLLTSLSYKVRMQAL 195
>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
Length = 659
Score = 37.7 bits (86), Expect = 0.027
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 6/164 (3%)
Query: 282 GPNEKIQAVIDSGVCRRLVELLMH--NDYKVASPALRAVGNIVTGDDIQTQVILNCSALP 339
G N++ +I G RL+ LL + ++ + +G++ G + + +L+C +P
Sbjct: 35 GNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIP 94
Query: 340 CLLHLLSSPKESIRKEACWTISNI-TAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEA 398
LL L SP + + I T+ + DA + P L+ +L ++ + T++
Sbjct: 95 ALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYI 153
Query: 399 AWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVAL 442
++ G P+ L + G ++ + LLT + K+ AL
Sbjct: 154 CQIFSHCCKG--PDHQTILFNHGAVQNIAHLLTSLSYKVRMQAL 195
Score = 33.1 bits (74), Expect = 0.66
Identities = 43/218 (19%), Positives = 92/218 (42%), Gaps = 16/218 (7%)
Query: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA--GDSSVCR 202
A+ L N+ S + ++E+GAV + L S+ ++ +WAL N+A + +
Sbjct: 432 ASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKA 491
Query: 203 DYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV-----SPCLPVL 257
D +L L LL+ S L + + L NL + P K+ + +
Sbjct: 492 D-ILRSLSTEQLFRLLSDSD-LNVLMKTLGLLRNLLSTR---PHIDKIMSTHGKQIMQAV 546
Query: 258 SRLLFSSDS-DLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALR 316
+ +L + ++ L+ ++DG K + + + +++ + H+ K+ A+
Sbjct: 547 TLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMF 606
Query: 317 AVGNIVTGDD---IQTQVILNCSALPCLLHLLSSPKES 351
+ N++ ++ + Q L + +LH LS +S
Sbjct: 607 CISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDS 644
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,633,095
Number of Sequences: 37866
Number of extensions: 821136
Number of successful extensions: 3662
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 3248
Number of HSP's gapped (non-prelim): 276
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.