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Search of human proteins with 69122473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|69122473 connexin 45 [Homo sapiens]
(396 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122939172 connexin 45 [Homo sapiens] 817 0.0
gi|69122473 connexin 45 [Homo sapiens] 817 0.0
gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens] 358 6e-99
gi|22779877 connexin 46 [Homo sapiens] 244 1e-64
gi|55953076 connexin 50 [Homo sapiens] 238 5e-63
gi|14211941 gap junction protein, alpha 10 [Homo sapiens] 238 7e-63
gi|32483412 connexin 40 [Homo sapiens] 224 8e-59
gi|6631083 connexin 40 [Homo sapiens] 224 8e-59
gi|62865885 connexin 37 [Homo sapiens] 223 2e-58
gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens] 223 2e-58
gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens] 218 8e-57
gi|4504001 connexin 43 [Homo sapiens] 217 1e-56
gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens] 178 9e-45
gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens] 173 2e-43
gi|42558283 gap junction protein beta 2 [Homo sapiens] 171 1e-42
gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens] 171 1e-42
gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens] 171 1e-42
gi|159032020 gap junction protein, beta 6 [Homo sapiens] 160 2e-39
gi|158966714 gap junction protein, beta 6 [Homo sapiens] 160 2e-39
gi|158966717 gap junction protein, beta 6 [Homo sapiens] 160 2e-39
gi|40254837 gap junction protein, beta 6 [Homo sapiens] 160 2e-39
gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens] 157 2e-38
gi|23397464 gap junction protein, beta 4 [Homo sapiens] 155 5e-38
gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens] 144 2e-34
gi|145699105 connexin40.1 [Homo sapiens] 142 5e-34
gi|54607056 connexin 31 [Homo sapiens] 138 1e-32
gi|13128960 connexin 31 [Homo sapiens] 138 1e-32
gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens] 112 6e-25
gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens] 112 6e-25
gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens] 112 6e-25
>gi|122939172 connexin 45 [Homo sapiens]
Length = 396
Score = 817 bits (2110), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ
Sbjct: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN
Sbjct: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
Query: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI 396
NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI
Sbjct: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI 396
>gi|69122473 connexin 45 [Homo sapiens]
Length = 396
Score = 817 bits (2110), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ
Sbjct: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN
Sbjct: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQN 360
Query: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI 396
NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI
Sbjct: 361 NPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI 396
>gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens]
Length = 439
Score = 358 bits (918), Expect = 6e-99
Identities = 211/444 (47%), Positives = 265/444 (59%), Gaps = 56/444 (12%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSWSFLTRLLEEIHNHSTFVGK+WLTVL+VFRIVLTAVGGE+IY DEQ+KF CNT QPGC
Sbjct: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYDAFAPLSHVRFWVFQI++++TPSVMYLGYA+H++A+ E ++A R +P R
Sbjct: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQER-RRALRRRPGPRR 122
Query: 121 WKQ------HRALEETEEDNEEDPMMYPEMELESDK------------------------ 150
+ H E + EE+PM+ E E ++
Sbjct: 123 APRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAV 182
Query: 151 --ENKEQSQPKP--KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPF 206
+ K P P +HDGRRRI+ +GLM++YV QL+AR FEV FL+GQY LYGF+V PF
Sbjct: 183 GADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPF 242
Query: 207 YVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKR 266
+ CSR PCPH +DCF+SRPTEKT+FLL+MY V+ LCLLLN+ EM HLG G+ +D++ +R
Sbjct: 243 FPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRR 302
Query: 267 RELEDPGAYNYPFTWNTPSAPP--GYNIAVKPDQIQYTELSNAKIAYKQNKANTA-QEQQ 323
P + P P A P +A PD + A+ QN AN A Q +
Sbjct: 303 ---GPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALR 359
Query: 324 YGSHEENLPAD------LEALQREIRMA---QERLDLAVQA--YSHQNNPHGPREKKAKV 372
G+ + D L A R A R A A Q P AK
Sbjct: 360 DGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAK- 418
Query: 373 GSKAGSNKSTASSKSGDGKTSVWI 396
+AGS K +ASS+ DGKT+VWI
Sbjct: 419 -PRAGSEKGSASSR--DGKTTVWI 439
>gi|22779877 connexin 46 [Homo sapiens]
Length = 435
Score = 244 bits (622), Expect = 1e-64
Identities = 131/289 (45%), Positives = 172/289 (59%), Gaps = 38/289 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+RFW QII V+TP+++YLG+ +H I +ME +KK R
Sbjct: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRME----EKKKER--------- 109
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKP-KHDGRRRIREDG-LMKIYVLQ 180
EE E+ E P KE Q P D R R+R G L++ YV
Sbjct: 110 -----EEEEQLKRESP------------SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFN 152
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
++ +T+FEVGF+ GQYFLYGF++ P Y C R PCP+ +DCFISRPTEKTIF++ M V
Sbjct: 153 IIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVAC 212
Query: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPF-TWNTPSAPP 288
LLLN+ E+ HLG+ ++ + S+ P A P T + P PP
Sbjct: 213 ASLLLNMLEIYHLGWKKLKQGVTSRL----GPDASEAPLGTADPPPLPP 257
>gi|55953076 connexin 50 [Homo sapiens]
Length = 433
Score = 238 bits (608), Expect = 5e-63
Identities = 118/273 (43%), Positives = 167/273 (61%), Gaps = 36/273 (13%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL +LEE++ HST +G++WLTVL +FRI++ E ++ DEQS FVCNT+QPGCEN
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R WV QII V+TPS+MY+G+A+H + R +
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYV--------------------RME 103
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHD--GRRRIREDG-LMKIYVL 179
+ R E EE ++ +Q K G ++ R +G L++ Y+
Sbjct: 104 EKRKSREAEELGQQ----------AGTNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYIC 153
Query: 180 QLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
++ +T+FEVGF++G YFLYGF++ P Y CSR PCP+ +DCF+SRPTEKTIF+L M V
Sbjct: 154 HIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVA 213
Query: 240 GLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDP 272
+ L LN+ E+ HLG IR +L +R +E P
Sbjct: 214 SVSLFLNVMELGHLGLKGIRSAL---KRPVEQP 243
>gi|14211941 gap junction protein, alpha 10 [Homo sapiens]
Length = 543
Score = 238 bits (607), Expect = 7e-63
Identities = 117/264 (44%), Positives = 167/264 (63%), Gaps = 23/264 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W+ L +LEE+H+HST VGKIWLT+L +FR+++ V E ++ DEQS F CNT QPGC N
Sbjct: 4 WNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPGCNN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
+CYD P+S +RFWV QII V++PS++Y+G+A++++ E KK+
Sbjct: 64 ICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKS----------H 113
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
+E + D EE + D+E + + K H ++ G L++ YVL +
Sbjct: 114 LRAQMENPDLDLEEQQRI--------DRELRRLEEQKRIH----KVPLKGCLLRTYVLHI 161
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
L R+V EVGF+IGQY LYGFQ+HP Y C++ PCP+ +DCF+SRPTEKTIF+L M+ + +
Sbjct: 162 LTRSVLEVGFMIGQYILYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAI 221
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSK 265
LLLNI E+ HLG I +L K
Sbjct: 222 SLLLNILEIFHLGIRKIMRTLYKK 245
>gi|32483412 connexin 40 [Homo sapiens]
Length = 358
Score = 224 bits (572), Expect = 8e-59
Identities = 135/385 (35%), Positives = 200/385 (51%), Gaps = 42/385 (10%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL LEE+H HST VGK+WLTVL +FR+++ ES + DEQ+ F C+T QPGC+N
Sbjct: 4 WSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV QII V+TPS++Y+G+A+H + E +
Sbjct: 64 VCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEK-----------------R 106
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
+ R E +E YP E+++ +G RI G L+ YV +
Sbjct: 107 KLREAERAKEVRGSGSYEYPV---------AEKAELSCWEEGNGRIALQGTLLNTYVCSI 157
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
L RT EVGF++GQYF+YG + +VC R PCPH ++C++SRPTEK +F++ M V L
Sbjct: 158 LIRTTMEVGFIVGQYFIYGIFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAAL 217
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSKRR-----ELEDPGAYNYPFTWNTPSAPPGYNIAVK- 295
LLL++ E+ HLG+ IR R+ +L P + + PP +N ++
Sbjct: 218 SLLLSLAELYHLGWKKIRQRFVKPRQHMAKCQLSGPSV----GIVQSCTPPPDFNQCLEN 273
Query: 296 -PDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQ 354
P + SN +A +QN N EQ G +E P + +Q E +
Sbjct: 274 GPGGKFFNPFSN-NMASQQNTDNLVTEQVRG--QEQTPGE-GFIQVRYGQKPEVPNGVSP 329
Query: 355 AYSHQNNPHGPREKKAKVGSKAGSN 379
+ + H + + +K SKA S+
Sbjct: 330 GHRLPHGYHSDKRRLSKASSKARSD 354
>gi|6631083 connexin 40 [Homo sapiens]
Length = 358
Score = 224 bits (572), Expect = 8e-59
Identities = 135/385 (35%), Positives = 200/385 (51%), Gaps = 42/385 (10%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WSFL LEE+H HST VGK+WLTVL +FR+++ ES + DEQ+ F C+T QPGC+N
Sbjct: 4 WSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV QII V+TPS++Y+G+A+H + E +
Sbjct: 64 VCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEK-----------------R 106
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVLQL 181
+ R E +E YP E+++ +G RI G L+ YV +
Sbjct: 107 KLREAERAKEVRGSGSYEYPV---------AEKAELSCWEEGNGRIALQGTLLNTYVCSI 157
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
L RT EVGF++GQYF+YG + +VC R PCPH ++C++SRPTEK +F++ M V L
Sbjct: 158 LIRTTMEVGFIVGQYFIYGIFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAAL 217
Query: 242 CLLLNIWEMLHLGFGTIRDSLNSKRR-----ELEDPGAYNYPFTWNTPSAPPGYNIAVK- 295
LLL++ E+ HLG+ IR R+ +L P + + PP +N ++
Sbjct: 218 SLLLSLAELYHLGWKKIRQRFVKPRQHMAKCQLSGPSV----GIVQSCTPPPDFNQCLEN 273
Query: 296 -PDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQ 354
P + SN +A +QN N EQ G +E P + +Q E +
Sbjct: 274 GPGGKFFNPFSN-NMASQQNTDNLVTEQVRG--QEQTPGE-GFIQVRYGQKPEVPNGVSP 329
Query: 355 AYSHQNNPHGPREKKAKVGSKAGSN 379
+ + H + + +K SKA S+
Sbjct: 330 GHRLPHGYHSDKRRLSKASSKARSD 354
>gi|62865885 connexin 37 [Homo sapiens]
Length = 333
Score = 223 bits (569), Expect = 2e-58
Identities = 125/334 (37%), Positives = 184/334 (55%), Gaps = 29/334 (8%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W FL +LL+++ HST VGKIWLTVL +FRI++ + GES++ DEQS F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SH+R+WV Q + V+TP+++YLG+ I+ + E
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREER------------------ 105
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
L + E + P P++E ++ ++ DGR RIR LM YV +L
Sbjct: 106 ----LRQKEGELRALPAKDPQVERALAAVERQMAKISVAEDGRLRIR-GALMGTYVASVL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
++V E GFL GQ+ LYG+ + P +VC R PCP+ +DCF+SRPTEKTIF++ M V +
Sbjct: 161 CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKRRELEDP--GAYNYPFTWNTPSAPPGYNIAVKPDQIQ 300
L+LN+ E++HL + + +++ + P G + P+T P P
Sbjct: 221 LVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPT 280
Query: 301 YTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD 334
Y LS++ +QN AN E++ S L D
Sbjct: 281 YNGLSSS----EQNWANLTTEERLASSRPPLFLD 310
>gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens]
Length = 515
Score = 223 bits (568), Expect = 2e-58
Identities = 113/263 (42%), Positives = 156/263 (59%), Gaps = 21/263 (7%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W+ L LEE+H HST +GKIWLT+L +FR+++ V E ++ DEQS F+CNTEQPGC N
Sbjct: 4 WNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPGCRN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+S +R+WV Q+I V++PS++Y+G+A++++ +E KA
Sbjct: 64 VCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKA----------- 112
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ E EE E P +E E + K + P L+ YV+ +
Sbjct: 113 --QLRVELEEVEFEMPRDRRRLEQELCQLEKRKLNKAP--------LRGTLLCTYVIHIF 162
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
R+V EVGF+IGQY LYGF + P + C PCP+ IDCF+SRPTEKTIFLL M + +
Sbjct: 163 TRSVVEVGFMIGQYLLYGFHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATIS 222
Query: 243 LLLNIWEMLHLGFGTIRDSLNSK 265
L LNI E+ HLGF I+ L K
Sbjct: 223 LFLNILEIFHLGFKKIKRGLWGK 245
>gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens]
Length = 321
Score = 218 bits (555), Expect = 8e-57
Identities = 107/278 (38%), Positives = 170/278 (61%), Gaps = 21/278 (7%)
Query: 3 WSFLTRLLEE-IHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCE 61
W+ L RLLE + HST +G+I LTV+++FRI++ A+ GE++Y DEQ+ FVCNT QPGC
Sbjct: 4 WTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCN 63
Query: 62 NVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKM---EHGEADKKAARSKPYA 118
CYD P+SH+R+WVFQII+V TPS+ ++ Y++H+ AK + R P +
Sbjct: 64 QACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPES 123
Query: 119 MRWKQHRALEETEEDNEEDPMMYPEM---ELESDKENKEQSQP--------KPKHDGRRR 167
+ + ED + + L++ + ++++P P G R
Sbjct: 124 IGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRT 183
Query: 168 I------REDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCF 221
R++G+ + Y++Q++ R E+GFL+GQYFLYGF V Y C+R PC +++C+
Sbjct: 184 ASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECY 243
Query: 222 ISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIR 259
+SRPTEKT+FL+ M+ V+G+C++LN+ E+ HLG+ I+
Sbjct: 244 VSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIK 281
>gi|4504001 connexin 43 [Homo sapiens]
Length = 382
Score = 217 bits (553), Expect = 1e-56
Identities = 124/338 (36%), Positives = 190/338 (56%), Gaps = 42/338 (12%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
VCYD P+SHVRFWV QII V+ P+++YL + + + K E K
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLN---------------K 108
Query: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
+ L+ + D M ++E++ K E+ G+ ++R GL++ Y++ +L
Sbjct: 109 KEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYIISIL 160
Query: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
+++FEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+ +
Sbjct: 161 FKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVS 220
Query: 243 LLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTWNTP 284
L LNI E+ ++ F ++D + K +D G+ Y P +P
Sbjct: 221 LALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSP 280
Query: 285 SAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
+PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 281 MSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
>gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens]
Length = 279
Score = 178 bits (451), Expect = 9e-45
Identities = 107/256 (41%), Positives = 139/256 (54%), Gaps = 40/256 (15%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M FL RLL E ST VG++ L VL+ FR+VL A G +Y DEQS+FVC+T+QPGC
Sbjct: 1 MCGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+ C+DAF PLS +RFWVFQ+ILVA PS +Y+G+ ++ + + H E K
Sbjct: 61 KAACFDAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHV--IWHWELSGKG--------- 109
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
K+ L + E N + P G +R L+ YV Q
Sbjct: 110 -KEEETLIQGREGNTDVP-------------------------GAGSLR---LLWAYVAQ 140
Query: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
L AR V E L QY LYGFQ+ + C R PC I C +SRP+EKTIFL M+GV+G
Sbjct: 141 LGARLVLEGAALGLQYHLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFLKTMFGVSG 200
Query: 241 LCLLLNIWEMLHLGFG 256
CLL E++ LG G
Sbjct: 201 FCLLFTFLELVLLGLG 216
>gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens]
Length = 294
Score = 173 bits (439), Expect = 2e-43
Identities = 93/252 (36%), Positives = 137/252 (54%), Gaps = 44/252 (17%)
Query: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
W+FL LL+ + S VG++WL V+++FRI++ A G +++ DEQ +FVCNT QPGC
Sbjct: 4 WAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPGCRQ 63
Query: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHG-EADKKAARSKPYAMRW 121
CYD P+SH RFW+F I+L++ P V+++ Y++H+ K G EA + A P
Sbjct: 64 TCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKEAGGAEAAAQCAPGLP----- 118
Query: 122 KQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQL 181
++Q P RR R + Y+L +
Sbjct: 119 ---------------------------------EAQCAPCALRARRAR-----RCYLLSV 140
Query: 182 LARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGL 241
R + E+ FL GQ LYGF+V P + C+ PCPH +DCF+SRPTEKT+F+L + V L
Sbjct: 141 ALRLLAELTFLGGQALLYGFRVAPHFACAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLL 200
Query: 242 CLLLNIWEMLHL 253
LL++ E+ HL
Sbjct: 201 SALLSVAELGHL 212
>gi|42558283 gap junction protein beta 2 [Homo sapiens]
Length = 226
Score = 171 bits (433), Expect = 1e-42
Identities = 89/255 (34%), Positives = 144/255 (56%), Gaps = 44/255 (17%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M W L +L ++ HST +GKIWLTVL +FRI++ V + ++ DEQ+ FVCNT QPGC
Sbjct: 1 MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYD + P+SH+R W Q+I V+TP+++ A+H +
Sbjct: 61 KNVCYDHYFPISHIRLWALQLIFVSTPALL---VAMH---------------------VA 96
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVL 179
+++H E + + E++S+ ++ E+ + +++R +G L Y
Sbjct: 97 YRRH-----------EKKRKFIKGEIKSEFKDIEEIK-------TQKVRIEGSLWWTYTS 138
Query: 180 QLLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGV 238
+ R +FE F+ Y +Y GF + C+ PCP+ +DCF+SRPTEKT+F + M V
Sbjct: 139 SIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAV 198
Query: 239 TGLCLLLNIWEMLHL 253
+G+C+LLN+ E+ +L
Sbjct: 199 SGICILLNVTELCYL 213
>gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 171 bits (432), Expect = 1e-42
Identities = 106/333 (31%), Positives = 168/333 (50%), Gaps = 72/333 (21%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M+W+ L LL ++ HST +G++WL+V+ +FRI++ V ES++ DE+S F+CNT QPGC
Sbjct: 1 MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+VCYD F P+SHVR W Q+ILV+TP+++ A+H +A +H +KK R + +
Sbjct: 61 NSVCYDQFFPISHVRLWSLQLILVSTPALL---VAMH-VAHQQH--IEKKMLRLEGHG-- 112
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVL 179
DP+ E++ R ++ G L YV+
Sbjct: 113 ----------------DPLHLEEVK-------------------RHKVHISGTLWWTYVI 137
Query: 180 QLLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGV 238
++ R +FE F+ Y LY G+ + C PCP+ +DCF+SRPTEKT+F + M
Sbjct: 138 SVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAA 197
Query: 239 TGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQ 298
+G+C++LN+ E+++L IR +R P G+ + P+
Sbjct: 198 SGICIILNVAEVVYL---IIRACARRAQRRSNPPSRKG-----------SGFGHRLSPE- 242
Query: 299 IQYTELSNAKIAYKQNKANTAQEQQYGSHEENL 331
YKQN+ N +Q GS ++ L
Sbjct: 243 ------------YKQNEINKLLSEQDGSLKDIL 263
>gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 171 bits (432), Expect = 1e-42
Identities = 106/333 (31%), Positives = 168/333 (50%), Gaps = 72/333 (21%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M+W+ L LL ++ HST +G++WL+V+ +FRI++ V ES++ DE+S F+CNT QPGC
Sbjct: 1 MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+VCYD F P+SHVR W Q+ILV+TP+++ A+H +A +H +KK R + +
Sbjct: 61 NSVCYDQFFPISHVRLWSLQLILVSTPALL---VAMH-VAHQQH--IEKKMLRLEGHG-- 112
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDG-LMKIYVL 179
DP+ E++ R ++ G L YV+
Sbjct: 113 ----------------DPLHLEEVK-------------------RHKVHISGTLWWTYVI 137
Query: 180 QLLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGV 238
++ R +FE F+ Y LY G+ + C PCP+ +DCF+SRPTEKT+F + M
Sbjct: 138 SVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAA 197
Query: 239 TGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQ 298
+G+C++LN+ E+++L IR +R P G+ + P+
Sbjct: 198 SGICIILNVAEVVYL---IIRACARRAQRRSNPPSRKG-----------SGFGHRLSPE- 242
Query: 299 IQYTELSNAKIAYKQNKANTAQEQQYGSHEENL 331
YKQN+ N +Q GS ++ L
Sbjct: 243 ------------YKQNEINKLLSEQDGSLKDIL 263
>gi|159032020 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 160 bits (405), Expect = 2e-39
Identities = 89/254 (35%), Positives = 135/254 (53%), Gaps = 42/254 (16%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M W L + ++ HST +GK+W+TV+ +FR+++ V + ++ DEQ FVCNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYD F P+SH+R W Q+I V+TP+++ A+H +A H E +K R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALL---VAMH-VAYYRH-ETTRKFRRG------ 109
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
E+ N+ ++E K+ K + E L Y
Sbjct: 110 ----------EKRND-------FKDIEDIKKQKVRI-------------EGSLWWTYTSS 139
Query: 181 LLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+ R +FE F+ YFLY G+ + C PCP+ +DCFISRPTEKT+F + M +
Sbjct: 140 IFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISAS 199
Query: 240 GLCLLLNIWEMLHL 253
+C+LLN+ E+ +L
Sbjct: 200 VICMLLNVAELCYL 213
>gi|158966714 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 160 bits (405), Expect = 2e-39
Identities = 89/254 (35%), Positives = 135/254 (53%), Gaps = 42/254 (16%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M W L + ++ HST +GK+W+TV+ +FR+++ V + ++ DEQ FVCNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYD F P+SH+R W Q+I V+TP+++ A+H +A H E +K R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALL---VAMH-VAYYRH-ETTRKFRRG------ 109
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
E+ N+ ++E K+ K + E L Y
Sbjct: 110 ----------EKRND-------FKDIEDIKKQKVRI-------------EGSLWWTYTSS 139
Query: 181 LLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+ R +FE F+ YFLY G+ + C PCP+ +DCFISRPTEKT+F + M +
Sbjct: 140 IFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISAS 199
Query: 240 GLCLLLNIWEMLHL 253
+C+LLN+ E+ +L
Sbjct: 200 VICMLLNVAELCYL 213
>gi|158966717 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 160 bits (405), Expect = 2e-39
Identities = 89/254 (35%), Positives = 135/254 (53%), Gaps = 42/254 (16%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M W L + ++ HST +GK+W+TV+ +FR+++ V + ++ DEQ FVCNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYD F P+SH+R W Q+I V+TP+++ A+H +A H E +K R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALL---VAMH-VAYYRH-ETTRKFRRG------ 109
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
E+ N+ ++E K+ K + E L Y
Sbjct: 110 ----------EKRND-------FKDIEDIKKQKVRI-------------EGSLWWTYTSS 139
Query: 181 LLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+ R +FE F+ YFLY G+ + C PCP+ +DCFISRPTEKT+F + M +
Sbjct: 140 IFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISAS 199
Query: 240 GLCLLLNIWEMLHL 253
+C+LLN+ E+ +L
Sbjct: 200 VICMLLNVAELCYL 213
>gi|40254837 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 160 bits (405), Expect = 2e-39
Identities = 89/254 (35%), Positives = 135/254 (53%), Gaps = 42/254 (16%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M W L + ++ HST +GK+W+TV+ +FR+++ V + ++ DEQ FVCNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVCYD F P+SH+R W Q+I V+TP+++ A+H +A H E +K R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALL---VAMH-VAYYRH-ETTRKFRRG------ 109
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
E+ N+ ++E K+ K + E L Y
Sbjct: 110 ----------EKRND-------FKDIEDIKKQKVRI-------------EGSLWWTYTSS 139
Query: 181 LLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
+ R +FE F+ YFLY G+ + C PCP+ +DCFISRPTEKT+F + M +
Sbjct: 140 IFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISAS 199
Query: 240 GLCLLLNIWEMLHL 253
+C+LLN+ E+ +L
Sbjct: 200 VICMLLNVAELCYL 213
>gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens]
Length = 223
Score = 157 bits (397), Expect = 2e-38
Identities = 89/254 (35%), Positives = 128/254 (50%), Gaps = 54/254 (21%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
MSW FL LL ++ +ST G IWL V+ VFR+++ V E ++ DEQ +F CN+ QPGC
Sbjct: 1 MSWMFLRDLLSGVNKYSTGTGWIWLAVVFVFRLLVYMVAAEHVWKDEQKEFECNSRQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
+NVC+D F P+S VR W Q+I+V+TPS++ + + + E +K R K Y
Sbjct: 61 KNVCFDDFFPISQVRLWALQLIMVSTPSLLV-------VLHVAYHEGREKRHRKKLYVSP 113
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
+ GL Y++
Sbjct: 114 GTM----------------------------------------------DGGLWYAYLIS 127
Query: 181 LLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
L+ +T FE+GFL+ Y LY GF V C PCP+ +DCFIS+PTEKTIF+L + +
Sbjct: 128 LIVKTGFEIGFLVLFYKLYDGFSVPYLIKCDLKPCPNTVDCFISKPTEKTIFILFLVITS 187
Query: 240 GLCLLLNIWEMLHL 253
LC++LN E+ L
Sbjct: 188 CLCIVLNFIELSFL 201
>gi|23397464 gap junction protein, beta 4 [Homo sapiens]
Length = 266
Score = 155 bits (393), Expect = 5e-38
Identities = 82/254 (32%), Positives = 128/254 (50%), Gaps = 47/254 (18%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M+W+FL LL ++ +ST + +IWL+V+ +FR+++ V E ++ DEQ FVCNT+QPGC
Sbjct: 1 MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
NVCYD F P+SHVR W Q+ILV PS++ + + +
Sbjct: 61 PNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMH------------------------VA 96
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
+++ R + + P +Y + + GL Y+L
Sbjct: 97 YREERERKHHLKHGPNAPSLYDNLSK----------------------KRGGLWWTYLLS 134
Query: 181 LLARTVFEVGFLIGQYFLY-GFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
L+ + + GFL + LY + + CS PCPH +DC+ISRPTEK +F M
Sbjct: 135 LIFKAAVDAGFLYIFHRLYKDYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTA 194
Query: 240 GLCLLLNIWEMLHL 253
+C+LLN+ E+ +L
Sbjct: 195 AICILLNLSEVFYL 208
>gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens]
Length = 273
Score = 144 bits (362), Expect = 2e-34
Identities = 81/254 (31%), Positives = 129/254 (50%), Gaps = 47/254 (18%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M+WS LL ++ +ST G+IWL+++ +FR+++ V E ++ D+ F CNT QPGC
Sbjct: 1 MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
NVC+D F P+SHVR W Q+ILV PS++ + + ++ ++
Sbjct: 61 SNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYR-------------------EVQ 101
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
K+HR E+ EN + P G++R GL YV
Sbjct: 102 EKRHR---------------------EAHGENSGRLYLNP---GKKR---GGLWWTYVCS 134
Query: 181 LLARTVFEVGFL-IGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVT 239
L+ + ++ FL + F + + P C PCP+ +DCFIS+P+EK IF L M
Sbjct: 135 LVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATA 194
Query: 240 GLCLLLNIWEMLHL 253
+C+LLN+ E+++L
Sbjct: 195 AICILLNLVELIYL 208
>gi|145699105 connexin40.1 [Homo sapiens]
Length = 370
Score = 142 bits (358), Expect = 5e-34
Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 35/243 (14%)
Query: 9 LLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAF 68
L+ ++ + T VGK+W + ++ R+++ + G +Y DEQ +FVCNT QPGC NVCYD F
Sbjct: 10 LIITLNCNVTMVGKLWFVLTMLLRMLVIVLAGRPVYQDEQERFVCNTLQPGCANVCYDVF 69
Query: 69 APLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALE 128
+P+SH+RFW+ Q + V PS ++ Y +H+ A + AL
Sbjct: 70 SPVSHLRFWLIQGVCVLLPSAVFSVYVLHRGATL----------------------AALG 107
Query: 129 ETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFE 188
+ +P + ++ P+P + R ++ Y++ LL RT+ E
Sbjct: 108 PRRCPDPREP------------ASGQRRCPRPFGE-RGGLQVPDFSAGYIIHLLLRTLLE 154
Query: 189 VGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIW 248
F YFL+GF + C+R PC +DC++SRPTEK++ +L ++ V+ L LL +
Sbjct: 155 AAFGALHYFLFGFLAPKKFPCTRPPCTGVVDCYVSRPTEKSLLMLFLWAVSALSFLLGLA 214
Query: 249 EML 251
+++
Sbjct: 215 DLV 217
>gi|54607056 connexin 31 [Homo sapiens]
Length = 270
Score = 138 bits (347), Expect = 1e-32
Identities = 78/255 (30%), Positives = 128/255 (50%), Gaps = 48/255 (18%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M W L LL ++ +ST G+IWL+V+ VFR+++ V E ++ DEQ F CNT+QPGC
Sbjct: 1 MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
NVCYD + P+S++R W Q+I V PS++ + +H +
Sbjct: 61 TNVCYDNYFPISNIRLWALQLIFVTCPSLLVI---LH---------------------VA 96
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
+++ R ++ ++ +Y D K + GL Y+
Sbjct: 97 YREERERRHRQKHGDQCAKLY-------DNAGK---------------KHGGLWWTYLFS 134
Query: 181 LLARTVFEVGFLIGQYFL-YGFQVHPFYVCSRL-PCPHKIDCFISRPTEKTIFLLIMYGV 238
L+ + + E FL + L +GF + C+ + PCP+ +DC+I+RPTEK IF M G
Sbjct: 135 LIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGA 194
Query: 239 TGLCLLLNIWEMLHL 253
+ +C++L I E+ +L
Sbjct: 195 SAVCIVLTICELCYL 209
>gi|13128960 connexin 31 [Homo sapiens]
Length = 270
Score = 138 bits (347), Expect = 1e-32
Identities = 78/255 (30%), Positives = 128/255 (50%), Gaps = 48/255 (18%)
Query: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
M W L LL ++ +ST G+IWL+V+ VFR+++ V E ++ DEQ F CNT+QPGC
Sbjct: 1 MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGC 60
Query: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
NVCYD + P+S++R W Q+I V PS++ + +H +
Sbjct: 61 TNVCYDNYFPISNIRLWALQLIFVTCPSLLVI---LH---------------------VA 96
Query: 121 WKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ 180
+++ R ++ ++ +Y D K + GL Y+
Sbjct: 97 YREERERRHRQKHGDQCAKLY-------DNAGK---------------KHGGLWWTYLFS 134
Query: 181 LLARTVFEVGFLIGQYFL-YGFQVHPFYVCSRL-PCPHKIDCFISRPTEKTIFLLIMYGV 238
L+ + + E FL + L +GF + C+ + PCP+ +DC+I+RPTEK IF M G
Sbjct: 135 LIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGA 194
Query: 239 TGLCLLLNIWEMLHL 253
+ +C++L I E+ +L
Sbjct: 195 SAVCIVLTICELCYL 209
>gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 112 bits (280), Expect = 6e-25
Identities = 52/86 (60%), Positives = 66/86 (76%)
Query: 9 LLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAF 68
LL E HST VG++ VL+ FR+VL A G +Y DEQS+FVC+T+QPGC+ C+DAF
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 69 APLSHVRFWVFQIILVATPSVMYLGY 94
PLS +RFWVFQ+ILVA PSV+Y+GY
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
>gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 112 bits (280), Expect = 6e-25
Identities = 52/86 (60%), Positives = 66/86 (76%)
Query: 9 LLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAF 68
LL E HST VG++ VL+ FR+VL A G +Y DEQS+FVC+T+QPGC+ C+DAF
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 69 APLSHVRFWVFQIILVATPSVMYLGY 94
PLS +RFWVFQ+ILVA PSV+Y+GY
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
>gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 112 bits (280), Expect = 6e-25
Identities = 52/86 (60%), Positives = 66/86 (76%)
Query: 9 LLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAF 68
LL E HST VG++ VL+ FR+VL A G +Y DEQS+FVC+T+QPGC+ C+DAF
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 69 APLSHVRFWVFQIILVATPSVMYLGY 94
PLS +RFWVFQ+ILVA PSV+Y+GY
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,247,775
Number of Sequences: 37866
Number of extensions: 732124
Number of successful extensions: 4085
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 3857
Number of HSP's gapped (non-prelim): 228
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.