Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 68348716
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens]
(1251 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens] 2509 0.0
gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens] 2443 0.0
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 650 0.0
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 545 e-154
gi|87162461 fragile X mental retardation 2 [Homo sapiens] 447 e-125
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 77 1e-13
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 70 1e-11
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 70 1e-11
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 69 3e-11
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 67 1e-10
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor... 65 4e-10
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 65 4e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 1e-09
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 63 2e-09
gi|55741677 SET domain containing 1A [Homo sapiens] 61 6e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 60 1e-08
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 60 1e-08
gi|169166609 PREDICTED: similar to ribonucleic acid binding prot... 59 2e-08
gi|113415994 PREDICTED: similar to ribonucleic acid binding prot... 59 2e-08
gi|113415504 PREDICTED: similar to ribonucleic acid binding prot... 59 3e-08
gi|169166499 PREDICTED: similar to ribonucleic acid binding prot... 59 3e-08
gi|113415498 PREDICTED: similar to ribonucleic acid binding prot... 59 3e-08
gi|88973230 PREDICTED: similar to ribonucleic acid binding prote... 59 3e-08
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 59 3e-08
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H... 57 8e-08
gi|6857826 RNA-binding protein S1, serine-rich domain [Homo sapi... 57 8e-08
gi|18379334 RNA-binding protein S1, serine-rich domain [Homo sap... 57 8e-08
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 56 2e-07
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens] 55 3e-07
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap... 55 3e-07
>gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens]
Length = 1251
Score = 2509 bits (6503), Expect = 0.0
Identities = 1251/1251 (100%), Positives = 1251/1251 (100%)
Query: 1 MDSFDLALLQEWDLESLWGEDILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERR 60
MDSFDLALLQEWDLESLWGEDILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERR
Sbjct: 1 MDSFDLALLQEWDLESLWGEDILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERR 60
Query: 61 NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV 120
NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV
Sbjct: 61 NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV 120
Query: 121 PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP 180
PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP
Sbjct: 121 PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP 180
Query: 181 SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN 240
SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN
Sbjct: 181 SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN 240
Query: 241 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA 300
FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA
Sbjct: 241 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA 300
Query: 301 RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD 360
RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD
Sbjct: 301 RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD 360
Query: 361 SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS 420
SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS
Sbjct: 361 SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS 420
Query: 421 AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS 480
AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS
Sbjct: 421 AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS 480
Query: 481 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ 540
PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ
Sbjct: 481 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ 540
Query: 541 PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA 600
PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA
Sbjct: 541 PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA 600
Query: 601 PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA 660
PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA
Sbjct: 601 PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA 660
Query: 661 SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT 720
SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT
Sbjct: 661 SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT 720
Query: 721 VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS 780
VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS
Sbjct: 721 VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS 780
Query: 781 PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP 840
PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP
Sbjct: 781 PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP 840
Query: 841 KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM 900
KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM
Sbjct: 841 KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM 900
Query: 901 LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH 960
LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH
Sbjct: 901 LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH 960
Query: 961 NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV 1020
NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV
Sbjct: 961 NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV 1020
Query: 1021 EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP 1080
EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP
Sbjct: 1021 EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP 1080
Query: 1081 EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG 1140
EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG
Sbjct: 1081 EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG 1140
Query: 1141 TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW 1200
TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW
Sbjct: 1141 TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW 1200
Query: 1201 EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS 1251
EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS
Sbjct: 1201 EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS 1251
>gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens]
Length = 1226
Score = 2443 bits (6331), Expect = 0.0
Identities = 1225/1251 (97%), Positives = 1225/1251 (97%), Gaps = 25/1251 (1%)
Query: 1 MDSFDLALLQEWDLESLWGEDILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERR 60
MDSFDLALLQEWDLESL VYEPDRNALRRKERERR
Sbjct: 1 MDSFDLALLQEWDLESL-------------------------CVYEPDRNALRRKERERR 35
Query: 61 NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV 120
NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV
Sbjct: 36 NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV 95
Query: 121 PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP 180
PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP
Sbjct: 96 PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP 155
Query: 181 SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN 240
SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN
Sbjct: 156 SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN 215
Query: 241 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA 300
FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA
Sbjct: 216 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA 275
Query: 301 RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD 360
RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD
Sbjct: 276 RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD 335
Query: 361 SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS 420
SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS
Sbjct: 336 SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS 395
Query: 421 AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS 480
AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS
Sbjct: 396 AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS 455
Query: 481 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ 540
PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ
Sbjct: 456 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ 515
Query: 541 PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA 600
PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA
Sbjct: 516 PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA 575
Query: 601 PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA 660
PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA
Sbjct: 576 PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA 635
Query: 661 SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT 720
SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT
Sbjct: 636 SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT 695
Query: 721 VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS 780
VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS
Sbjct: 696 VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS 755
Query: 781 PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP 840
PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP
Sbjct: 756 PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP 815
Query: 841 KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM 900
KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM
Sbjct: 816 KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM 875
Query: 901 LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH 960
LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH
Sbjct: 876 LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH 935
Query: 961 NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV 1020
NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV
Sbjct: 936 NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV 995
Query: 1021 EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP 1080
EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP
Sbjct: 996 EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP 1055
Query: 1081 EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG 1140
EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG
Sbjct: 1056 EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG 1115
Query: 1141 TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW 1200
TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW
Sbjct: 1116 TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW 1175
Query: 1201 EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS 1251
EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS
Sbjct: 1176 EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS 1226
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 650 bits (1677), Expect = 0.0
Identities = 463/1271 (36%), Positives = 650/1271 (51%), Gaps = 182/1271 (14%)
Query: 48 DRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYK-TNKGDELSNRIQNTLGNYDEMKD 106
DRN LR KERERRNQE QQ + F S LF+EPYK T+K D+LS+RIQ+ LGNYDEMKD
Sbjct: 5 DRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKD 64
Query: 107 FLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQS 166
F+ DRS LV +PKP VP + K + +F + SS T PA Q
Sbjct: 65 FIGDRSIPK-LVAIPKPTVPPSADEKSNPNFFEQRHGGSHQSS--KWTPVGPAPSTSQSQ 121
Query: 167 KR------------------------------------GTMGWQKAGHPPSDGQQRATQQ 190
KR G+ +K H + R++
Sbjct: 122 KRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSSP 181
Query: 191 GSLRTLLG-----------DGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQ 239
G + + D ++ R+K + + + R P + +HS+ Q
Sbjct: 182 GKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHST-----Q 236
Query: 240 NFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEP 299
+FPPSL SK + + QKPTAYVRPMDGQ+ PKL S +S G ++ +P
Sbjct: 237 SFPPSLMSKSNSMLQKPTAYVRPMDGQESM---EPKLSSEHYSS----QSHGNSMTELKP 289
Query: 300 ARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFP 357
+ +KA L+K IP Q ++ + SCV+EI++EMT W PPL+AI P K EP+KFPFP
Sbjct: 290 S-SKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFP 348
Query: 358 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRAL 417
K+SQ + G K+ + P NG + SML+DDLKLSS E+ + +Q +T R+
Sbjct: 349 TKESQQSNFGTGEQKRYN--PSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRST 406
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPH 477
S N S +S+G+ +S SSS S SESSSGSDSE+ESSSS+SE ++P
Sbjct: 407 PGS------NSEPSHHNSEGADNSRDD--SSSHSGSESSSGSDSESESSSSDSEANEPSQ 458
Query: 478 FSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGK-VP 536
+SPE EP +NKWQLD WLNKVNPHK +S+ S Y +E Q G
Sbjct: 459 SASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGRE--QGTGNSYT 516
Query: 537 DVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAP 596
D P KE S +T K S +QKSP
Sbjct: 517 DTSGP----KETSSATPGRDS-KTIQKGSESGRGRQKSP--------------------- 550
Query: 597 AENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCG 656
A++ RR+ GKK ++ E+ +A + + E D + +P K G
Sbjct: 551 AQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASS---MPSSRHKAATKG 607
Query: 657 NNRASHRKELRSSV--TCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL--ESEQEE 712
+ + + +KE +SS T EK++ + S+ KS+E IET++SSS S L S+ +
Sbjct: 608 SRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPK 667
Query: 713 YPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVP 772
YP S V S+ D ++ + P
Sbjct: 668 YPESNRTPVKPSSVEEEDSFFRQRMFS--------------------------------P 695
Query: 773 FGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSD 832
ELLSPL + D+ L VKIDL LL+RIP +P + P + ++ P HT +
Sbjct: 696 MEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPG----KPYKETEPPKGEKKNVPEKHTRE 751
Query: 833 TP---AEKALPKSKRKRKCDNEDDYR---------EIKKSQGEKDSSSRLATSTSNTLSA 880
+EK K KRK K NEDD R E K S G K SS+R ++ S
Sbjct: 752 AQKQASEKVSNKGKRKHK--NEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQSAAKEK 809
Query: 881 NHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSK 940
+ V K E R S + K S TS S N S+S+SK
Sbjct: 810 DLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKN------SSSTSK 863
Query: 941 KPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPR 1000
+ K + + ++ + A ++S N P P +P + + +R KLVFDD
Sbjct: 864 QKKTEGKTSSSSKEVKEKAPSSSSNCP---------PSAPTLDSSKP-RRTKLVFDDRNY 913
Query: 1001 SADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSET 1060
SAD+++QEAK++KH ADA+ ++F KA+ Y +A +SFIECGNA+E+ ESKSP+ MYSET
Sbjct: 914 SADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSET 973
Query: 1061 VELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFK 1120
V+LI+Y M+LK + P+AT DK+L LC RC +LLY R+F+LK+++A+KYSK L ++ K
Sbjct: 974 VDLIKYTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLK 1033
Query: 1121 NSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIH 1180
NS +QAPSP G K+ G PSP+SP SP +S S+ASA S V+IPQ+IH
Sbjct: 1034 NSYNNSQAPSP-GLGSKAVGMPSPVSPKLSPGNSGNYSSGASSASASGSS--VTIPQKIH 1090
Query: 1181 QMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS-MEHLVQYSQQ 1239
QMAA++V +T++ L++ + W+ A+ L+KE +EFF +LD +MGP+ ++S M LV+Y++Q
Sbjct: 1091 QMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVRYTRQ 1150
Query: 1240 GLHWLRNSAHL 1250
GLHWLR A L
Sbjct: 1151 GLHWLRQDAKL 1161
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 545 bits (1403), Expect = e-154
Identities = 436/1292 (33%), Positives = 625/1292 (48%), Gaps = 182/1292 (14%)
Query: 43 SVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYD 102
S+Y DRN LR +E+ERRNQE Q+ F LF EPYKT KGDELS+RIQN LGNY+
Sbjct: 6 SLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYE 65
Query: 103 EMKDFLTDRSNQSHL------VGVPK-PGVP-----------QTPVNKIDEHF------- 137
E+K+FL+ +S+ L +G PK P +P T V+ H
Sbjct: 66 EVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLS 125
Query: 138 ---------VADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGW----QKAGHPPSDGQ 184
+A R + P S+ + + P + + Q + G G+ K G +DG
Sbjct: 126 VGNISHNPKMAQPRTEPMP-SLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGD 184
Query: 185 QRATQQGSL-RTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSS----GHC-- 237
A+ S L + P + + QT R + H SS G+C
Sbjct: 185 HCASVTDSAPERELSPLISLPSP-VPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPA 243
Query: 238 ---------------------------VQNF-PPSLASKPSLVQQKPTAYVRPMDGQDQA 269
Q F PPSL SK +QQKPTAYVRPMDGQDQA
Sbjct: 244 KSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQA 303
Query: 270 PDESPKLKSSSETSVHCTSYRGVPASKPE-PARAKAKLSKFSIPKQGEESRSGETNSCVE 328
P ESP+LK E YR K + AKAKL+K +P Q E CVE
Sbjct: 304 PSESPELKPLPE------DYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVE 357
Query: 329 EIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTS 386
EI++EMT W PPL+AI P EP+KFPFP KDSQ VSS N K+ D ++ N
Sbjct: 358 EILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQ 417
Query: 387 NT-SMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG 445
T SMLEDDL+LS E+ + +Q ++ S SA P+ S+P +S+ SSS
Sbjct: 418 GTSSMLEDDLQLSDSEDSDSEQTPEKPP----SSSA---PPSAPQSLPEPV-ASAHSSSA 469
Query: 446 SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVN-PHK 504
S S+SDS+SS SDSE+ESSSS+SE ++P +PE EP ++NKWQLD WL KV+ P
Sbjct: 470 ESESTSDSDSS--SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAA 527
Query: 505 PPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKA 564
PP E + P + + G E ++ P++++KA
Sbjct: 528 PP----------EGPRSTEPPRRHPESKGSSDSATSQEHSE-------SKDPPPKSSSKA 570
Query: 565 PGSKGVKQKSPPAAVAVAVSAAAPPP---AVPCAPAENAPAPARRSAGKKPTRRTERTSA 621
P ++PP AP P + +PA+ P P R++ G K ++ + SA
Sbjct: 571 P-------RAPP---------EAPHPGKRSCQKSPAQQEP-PQRQTVGTKQPKKPVKASA 613
Query: 622 GDGANCH-RPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGL 680
G+ + E G+ + K + G RA+ E + +V + +
Sbjct: 614 RAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHK 673
Query: 681 SRIVPKSKEFIETESSSSSSSSDSDLESEQEEY----PLSKAQTVAASASSGNDQRLKEA 736
S + SK + S + ++E E+ PL+++Q S S ++A
Sbjct: 674 SSLPAPSK------ALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQA 727
Query: 737 AANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKID 796
+ +E + +P +LLSPL+D+ +SL VKI
Sbjct: 728 V---------------------VVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKIT 766
Query: 797 LTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYRE 856
L LLSRIP+ P G A A H+S+ + + K +KRK + E D +
Sbjct: 767 LDLLSRIPQ--PPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDC-D 823
Query: 857 IKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKY 916
KK + EK+ S+ S++ S++H + + P +++ K P P+S +S+ K
Sbjct: 824 NKKIRLEKEIKSQ-----SSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQ-KP 877
Query: 917 TSEDLTSSSRPN---GNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRP 973
L S R G SASS+K DS + K + ++SE+
Sbjct: 878 AKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTA 937
Query: 974 QTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAA 1033
P NG+ + ++ FD + AD M+EAK+MK KA+ M ++ GKA Y EA
Sbjct: 938 NPFPVPSLPNGNSKPGKPQVKFD--KQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAV 995
Query: 1034 LSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCL 1093
LSFIECG A E SKS Y++YSETV+LI++ M LK+ S A ++K A LC RC
Sbjct: 996 LSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQ 1055
Query: 1094 ALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPAS 1153
++L MFR K+D A+KYS+ L +F++SSK AQAPSP A STGTPSP+SP PSPAS
Sbjct: 1056 SILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIA---STGTPSPLSPMPSPAS 1112
Query: 1154 SVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREF 1213
SVGSQ S + + + +S P I M +++V+IT+ +L ++D WE A+ L ++N+EF
Sbjct: 1113 SVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEF 1172
Query: 1214 FNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLR 1245
F L + + L+SS+ LV Y++QG L+
Sbjct: 1173 FARLSTNVCTLALNSSLVDLVHYTRQGFQQLQ 1204
>gi|87162461 fragile X mental retardation 2 [Homo sapiens]
Length = 1311
Score = 447 bits (1149), Expect = e-125
Identities = 325/976 (33%), Positives = 475/976 (48%), Gaps = 115/976 (11%)
Query: 45 YEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYK----TNKGDELSNRIQNTLGN 100
YE DR+AL+++E ERRNQE QQ+D F+S + LF EPYK TNKGD L+NR+QNTLGN
Sbjct: 18 YEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEYTNKGDALANRVQNTLGN 77
Query: 101 YDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAA 160
YDEMK+ LT+ SNQ+HLVG+PK VPQ P NK + F + + + P +T S P
Sbjct: 78 YDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTHPSAPMP 137
Query: 161 VP---------VQQSKRGTMGWQKAGHPPSD--GQQRATQQGSLRTLLGDG--------- 200
P + +++ W + H PS Q + Q ++TL D
Sbjct: 138 PPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQSQAKLEDFF 197
Query: 201 -----------VGRQQPRAKQVCNV--------------------EVGLQTQERP-PAMA 228
V P AK+ N E +Q P A +
Sbjct: 198 VYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASS 257
Query: 229 AKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSE--TSVHC 286
SSG VQNFPP L K S+ QQKPTAYVRPMDGQDQAPD SP LK S E S
Sbjct: 258 LLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGN 317
Query: 287 TSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMT--WLPPLSAIQ 344
S+ + KP A +K KL KF+I + E S + SCVEEI+REMT W PL+++
Sbjct: 318 LSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDP-SCVEEILREMTHSWPTPLTSMH 376
Query: 345 APGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEEN 404
G E + F P ++SQ ++ G K D + S SMLEDDLKLSSDE++
Sbjct: 377 TAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDL 436
Query: 405 EQQAAQRTALRALSDSAVVQQPNCRTS-----VPSSKGSSSSSSSGSSSSSSDSESSSGS 459
E T A V++ R + + + + + +SG S SSS+SESSS S
Sbjct: 437 EPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSES 496
Query: 460 DSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESN 519
DS+TESS+++SE ++ P ++PE EP S+NKWQLDKWLNKV + E+
Sbjct: 497 DSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETI 556
Query: 520 QYYNPVKEDVQ-------DCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQ 572
P+ + ++ + +VP +P +E+ + S +E+ RPR K P +K +K
Sbjct: 557 SLPPPIIQPMEVQMKVKTNASQVP--AEP--KERPLLSLIREKARPRPTQKIPETKALKH 612
Query: 573 KSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEE 632
K + V ++R+ GKK ++ E+ ++ D +P
Sbjct: 613 KLSTTSETV----------------------SQRTIGKKQPKKVEKNTSTDEFTWPKPNI 650
Query: 633 PAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTC--EKRRTRGLSRIVPKSKEF 690
++ SV + P ++ + RKE R ++ EK++ RG +IVPKS+EF
Sbjct: 651 TSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREF 710
Query: 691 IETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGS 750
IET+SS+S S++D + + + P S GN + KE G+
Sbjct: 711 IETDSSTSDSNTDQEETLQIKVLP-------PCIISGGNTAKSKEIC---GASLTLSTLM 760
Query: 751 INARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE 810
++ + ++++ EE ++ +P + E+LSPL+D + +++LWVKIDL LLSR+P H
Sbjct: 761 SSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLH 820
Query: 811 PGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRL 870
+ P K++ + P T+ T EK PK KRK K + KK + E+ ++ L
Sbjct: 821 -AAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICL 879
Query: 871 ---ATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRP 927
S + + N +S K EK+ P+SPL + +
Sbjct: 880 LPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQ 939
Query: 928 NGNSLFTSASSSKKPK 943
+ N T +S KPK
Sbjct: 940 DKNIAMTGQITSTKPK 955
Score = 332 bits (852), Expect = 1e-90
Identities = 164/270 (60%), Positives = 213/270 (78%), Gaps = 12/270 (4%)
Query: 982 SNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGN 1041
S+ + +R KL FDD +ADY+MQEAK++KHKADA+ EKFGKA+NYA+AALSF ECGN
Sbjct: 1052 SSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGN 1111
Query: 1042 AMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMF 1101
AME+ P+E+KSPYTMYSETVEL+RYAMRLK + P A+ DK+LA LCYRCL+LLY RMF
Sbjct: 1112 AMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMF 1171
Query: 1102 RLKRDHAVKYSKALIDYFK-NSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGS 1160
+LK+DHA+KYS++L++YFK N+SK AQ PSPW ++GK+ TPSP+S N S + + G+
Sbjct: 1172 KLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKN--TPSPVSLN--NVSPINAMGN 1227
Query: 1161 LSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLL 1220
+N V+IPQRIH MAA+HV+IT+++L Y++W+MAD L +EN+EFF DLD L
Sbjct: 1228 CNNGP-------VTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTL 1280
Query: 1221 MGPVTLHSSMEHLVQYSQQGLHWLRNSAHL 1250
MGP+T HSSM +LV+Y +QGL WLR AHL
Sbjct: 1281 MGPLTQHSSMTNLVRYVRQGLCWLRIDAHL 1310
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 77.0 bits (188), Expect = 1e-13
Identities = 112/615 (18%), Positives = 232/615 (37%), Gaps = 13/615 (2%)
Query: 358 NKDSQLVSSGHNNPKKGDAEPESPD-NGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRA 416
+ DS S +++ ++ +S D N +S++ + D SSD + ++ + ++ +
Sbjct: 549 SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSS 608
Query: 417 LSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP 476
S + + + SSK S SS S S S SSDS SS SD+ S SS S S
Sbjct: 609 DSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDS 668
Query: 477 HFSSPEAEPASS--NKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGK 534
SS ++ +SS + D + + + ++S S+S+ + + D
Sbjct: 669 SDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728
Query: 535 VPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPC 594
S + ++ + S S + + + ++ +
Sbjct: 729 SNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDS 788
Query: 595 APAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRP 654
+ + ++ + S + ++ + + D + + + ++D+ +S +
Sbjct: 789 SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848
Query: 655 CGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYP 714
G++ S + SS + + + S S ESS+SS SSDS S+ +
Sbjct: 849 DGSDSDSSNRS-DSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSD 907
Query: 715 LSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFG 774
S + + S++S + ++ N S S N+ +SD + +
Sbjct: 908 SSNSSDSSDSSNSSDSSESSNSSDNSNSS-----DSSNSSDSSDSSDSSNSSDSSNSSDS 962
Query: 775 RNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTP 834
N S +S + D + S + S+ ++ S+S+ S++SD+
Sbjct: 963 SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 835 AEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPI 894
S + D + S DSS+ +S S+ S + + + + +
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082
Query: 895 NKNEKMLRSPISPLSDASKHKYTSEDLTSS----SRPNGNSLFTSASSSKKPKADSQLQP 950
++ S S SD+S +S+ SS S + NS +S SS +DS
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142
Query: 951 HGGDLTKAAHNNSEN 965
D ++++ ++ +
Sbjct: 1143 DSSDSSESSDSSDSS 1157
Score = 76.6 bits (187), Expect = 1e-13
Identities = 125/631 (19%), Positives = 231/631 (36%), Gaps = 30/631 (4%)
Query: 358 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRAL 417
+ DS+ SS N+ D S + +SN+S D SSD ++ + + +
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD----SSDSSDSSSSSDSSNSSDSS 690
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPH 477
S S SS SS SS S+S+SSDS+SS+ SDS S+SS+S S
Sbjct: 691 DSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSS 750
Query: 478 FSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPD 537
SS ++ + S+ + + + S+ S+SN N D D D
Sbjct: 751 NSSDSSDSSDSSN------SSDSSDSSDSSDSSDSSNSSDSNDSSN--SSDSSDSSNSSD 802
Query: 538 VCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPA 597
S S+ + ++ + S S + + + + + +
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSD-------SDS 855
Query: 598 ENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGN 657
N + S + + + + D ++ + E ++D+ +S + + + +
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSN--ESSNSSDSSDSSNSSDSDSSDS----S 909
Query: 658 NRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSK 717
N + SS + E + S S ++SS SS+SSDS S+ S
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969
Query: 718 AQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNE 777
+ S+ S N +++ + S + S N+ +SD + + +
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSS--NSSDSSNSS 1025
Query: 778 LLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEK 837
S DS + D + S + S+ ++ S+S+ S +SD+
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS 1085
Query: 838 ALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKN 897
S + D + S DSS +S S+ S + + + + + + +
Sbjct: 1086 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145
Query: 898 EKMLRSPISPLSDASKHKYTSEDLTSS-SRPNGNSLFTSASSSKKPKADSQLQPHGGDLT 956
+ S S SD+S +S+ SS S + NS +S SS +DS D +
Sbjct: 1146 DSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1205
Query: 957 KAAHNNSENIPLHKSRPQTKPWSPGSNGHRD 987
++ ++ + S S SN D
Sbjct: 1206 DSSDSSDSSDSSDSSDSSDSSDSSDSNESSD 1236
Score = 76.3 bits (186), Expect = 2e-13
Identities = 124/636 (19%), Positives = 243/636 (38%), Gaps = 54/636 (8%)
Query: 358 NKDSQLVSSGHNNPKKGDAEP-ESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRA 416
+ DS S ++ D++ +S D+ SN+S + S + N ++ +
Sbjct: 692 SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN 751
Query: 417 LSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP 476
SDS+ + S SS S SS SS SS+SS ++SS+ SDS S+SS+S S
Sbjct: 752 SSDSS--DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV-KEDVQDCGKV 535
SS ++ SSN + S+ S+S+ N D D
Sbjct: 810 SDSSDSSDSDSSNS-------------------SDSSNSSDSSDSSNSSDSSDSSDSSDG 850
Query: 536 PDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA 595
D S R S+ + + + +S ++ + S ++ + +
Sbjct: 851 SD-SDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS 909
Query: 596 PAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPC 655
+ ++ + S + + ++ +++ D +N + ++D+ +S +
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD--SSDSSNSS-------DSSNSS 960
Query: 656 GNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPL 715
++ +S + SS + + + S S ++SS+SS SSDS S+
Sbjct: 961 DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSD 1020
Query: 716 SKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGR 775
S + ++++S +D + ++ S S N+ +SD + +
Sbjct: 1021 SSNSSDSSNSSDSSDSS-DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS------- 1072
Query: 776 NELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPA 835
S DS + D + S + S+ ++ S+S+ S++SD+
Sbjct: 1073 ----SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128
Query: 836 EKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPIN 895
S + D E S DSS +S S+ S + + N + + +
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 896 KNEKMLRSPISPLSDASKHKYTSEDLTSS-------SRPNGNSLFTSASSSKKPKADSQL 948
++ S S SD+S +S+ SS S + +S +S SS +DS
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSN 1248
Query: 949 QPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNG 984
D + ++ + S++ +S Q+K + +NG
Sbjct: 1249 SSDSSDSSDSSDSTSDS--NDESDSQSKSGNGNNNG 1282
Score = 75.5 bits (184), Expect = 3e-13
Identities = 113/603 (18%), Positives = 217/603 (35%), Gaps = 25/603 (4%)
Query: 365 SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQ 424
S N+ D+ S + +S++S + D S + + + + + S
Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655
Query: 425 QPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE 484
+ S SS S SS SS SSSSS S SS SDS S+SSES S S
Sbjct: 656 SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS 715
Query: 485 PASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV-KEDVQDCGKVPDVCQPSL 543
SSN D + + N S S+S+ N D D D S
Sbjct: 716 SDSSNSNSSDSDSSNSSDSSDS---SNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 544 REKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAP 603
S+ + + + S ++ + S ++ + + + N+
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS 832
Query: 604 ARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHR 663
+ S + ++ + D + +R + ++D+ +S +S+
Sbjct: 833 SDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS----------------DSSNS 876
Query: 664 KELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAA 723
+ S + S S + ++SS+SS SSDS S+ E S + ++
Sbjct: 877 SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936
Query: 724 SASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLK 783
+S+ +D ++N + S ++ ++ + + + + ++
Sbjct: 937 DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD 996
Query: 784 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 843
SD S D + S + S+ ++ S+S+ S +SD+ S
Sbjct: 997 SSDSSNS----SDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 844 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 903
+ D + S DSS +S S+ S + + + + + + ++ S
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1112
Query: 904 PISPLSDASKHKYTSEDLTSS-SRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNN 962
S SD+S +S+ SS S + NS +S SS +DS D + ++ ++
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS 1172
Query: 963 SEN 965
+
Sbjct: 1173 DSS 1175
Score = 73.6 bits (179), Expect = 1e-12
Identities = 116/620 (18%), Positives = 234/620 (37%), Gaps = 68/620 (10%)
Query: 366 SGHNNPKKGDAE---PESPDNGTSNTSM--LEDDLKLSSD--------------EEENEQ 406
S +N+ +GDA ES DNG + S +DD +SD ++ ++
Sbjct: 481 SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKS 540
Query: 407 QAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESS 466
+ + + + SDS+ + + S S S+SSS S SS SDS SS SDS S+
Sbjct: 541 DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSN 600
Query: 467 SSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVK 526
SS+S S SS ++ + S +++S SES+ + K
Sbjct: 601 SSDSSDSSDSSDSSDSSDSSDS---------------------KSDSSKSESDSSDSDSK 639
Query: 527 EDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAA 586
D D + S + ++ + S S + + + +++
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699
Query: 587 APPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVP 646
+ + ++++ + ++ + + + + D +N ++D+ +S
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN--------SSDSSDSSDSSN 751
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
+ +N + SS + + + + S + SS SS+SSDS
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD 811
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQ 766
S+ + S + + S+ S + +++ + S + S N +S+ + +
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 767 FYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAP 826
+ S DS+E + D + S S+ ++ S+S+
Sbjct: 872 -----DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSD----------SSDSSNSSDSSD 916
Query: 827 PSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMN 886
S++SD+ + N D + S DSS+ S+ ++ S++ + N
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN----SSDSSNSSDSSDSN 972
Query: 887 INSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSS-SRPNGNSLFTSASSSKKPKAD 945
+ + N ++ S S SD+S +S+ SS S + NS +S SS +D
Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 946 SQLQPHGGDLTKAAHNNSEN 965
S D + ++ ++ +
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSS 1052
Score = 71.2 bits (173), Expect = 6e-12
Identities = 113/612 (18%), Positives = 226/612 (36%), Gaps = 25/612 (4%)
Query: 360 DSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 419
DS S +N+ G+ + DN S++ + D S + + + ++ SD
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD 573
Query: 420 SAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFS 479
S + S S S SS S +SS SSDS SS S ++SS S+S+ SK S
Sbjct: 574 SNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSK----S 629
Query: 480 SPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVC 539
++ + S D + + + N S+ S+S+ D D D
Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD-----SSDSSDSSSSSDSS 684
Query: 540 QPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAEN 599
S S+ E + + S S S ++ + + + +
Sbjct: 685 NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN--------SNSSDSDSSNSSDSSD 736
Query: 600 APAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNR 659
+ + S + ++ + + D +N + + + S + ++
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796
Query: 660 ASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQ 719
+S+ + +S S S ++SS SS+SSDS S+ + S +
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Query: 720 TVAASASSGNDQRLKEAAANGGSGPRAPVG-SINARTTSDIAKELEEQFYTLVPFGRNEL 778
+ S++S + +++ + S + S N+ +SD + + +
Sbjct: 857 NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD 916
Query: 779 LSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKA 838
S DS E + + + S + S+ ++ S+S+ S +SD+ + +
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 839 LPKSKRKRKCDNED-----DYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIP 893
S D+ D D + S DSS +S S+ S + + N + +
Sbjct: 977 SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 1036
Query: 894 INKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGG 953
+ ++ S S SD+S +S+ +S S + +S +S SS +DS +
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSD--SSDSSDSSDSSDSSDSSDSSESSDSSDSSNSS 1094
Query: 954 DLTKAAHNNSEN 965
D + ++ ++ +
Sbjct: 1095 DSSDSSDSSDSS 1106
Score = 69.7 bits (169), Expect = 2e-11
Identities = 113/614 (18%), Positives = 225/614 (36%), Gaps = 47/614 (7%)
Query: 358 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEE-----NEQQAAQRT 412
+ DS S+ +++ +S D+ S+ S D SSD + N ++ +
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 413 ALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEG 472
SDS+ N ++ S SS+SS S +SS SSDS SS SDS S SS S
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831
Query: 473 SKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV-KEDVQD 531
S SS ++ + S+ N+ + N S S+S+ N D D
Sbjct: 832 SSDSSNSSDSSDSSDSSDGSDSDSSNRSDS-------SNSSDSSDSSDSSNSSDSSDSSD 884
Query: 532 CGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 591
+ + S S + ++ + S + S + + + ++ +
Sbjct: 885 SNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS 944
Query: 592 VPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTK 651
+ + N+ + S + ++ S+ + + + ++D+ +S
Sbjct: 945 SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD-------- 996
Query: 652 TRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQE 711
++ ++ SS + + + S S ++SS SS SSDS S+
Sbjct: 997 ----SSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 712 EYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLV 771
+ S + ++ +S +D +++ + S N+ +SD + +
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS-NSSDSSDSSDSSDS------ 1105
Query: 772 PFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTS 831
S DS + D + S + S+ ++ S+S+ S +S
Sbjct: 1106 --------SDSSDSSD------SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS 1151
Query: 832 DTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVA 891
D+ S + D + S DSS +S S+ S + + + + +
Sbjct: 1152 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1211
Query: 892 IPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPH 951
+ ++ S S SD+++ S D + SS + +S + +S S +DS +
Sbjct: 1212 DSSDSSDSSDSSDSSDSSDSNESS-DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESD 1270
Query: 952 GGDLTKAAHNNSEN 965
+ +NN +
Sbjct: 1271 SQSKSGNGNNNGSD 1284
Score = 60.5 bits (145), Expect = 1e-08
Identities = 116/645 (17%), Positives = 234/645 (36%), Gaps = 73/645 (11%)
Query: 343 IQAPG-KVEP-TKFPFPNKDSQLVSSGHNN------PKKGDAEPESPD--NG-------T 385
I+ PG K EP K N S S G+++ +GD +P S D NG +
Sbjct: 423 IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGD-DPNSSDESNGNDDANSES 481
Query: 386 SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG 445
N S D +SDE ++ + + N ++ + G+ + S
Sbjct: 482 DNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSD 541
Query: 446 SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKP 505
S SDS S SDS S SS+S S +S +S +
Sbjct: 542 SGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS---------------- 585
Query: 506 PILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAP 565
+ S S+S+ + D D D S + K E ++
Sbjct: 586 -----DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640
Query: 566 GS--KGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGD 623
S S + + + +++ + + + ++ + + S + ++ +++ +
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSE 700
Query: 624 GANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRI 683
++ + ++D+ +S + + ++ +S+ + SS + + + S
Sbjct: 701 SSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSD--SSDSSDSSNSSDSSDS 758
Query: 684 VPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASAS-SGNDQRLKEAAANGGS 742
S ++SS SS SSDS S+ + S + ++++S S N +++ + S
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDS 818
Query: 743 GPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSR 802
S N+ +SD + + + G + S DS
Sbjct: 819 DSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN--------------- 863
Query: 803 IPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDN--EDDYREIKKS 860
S+ ++ S+S+ S +SD+ S N + D + S
Sbjct: 864 ------------SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS 911
Query: 861 QGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSED 920
DSS+ +S S+ S N + + ++ + + ++ S S SD+S +S+
Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 971
Query: 921 LTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSEN 965
+S S + NS +S SS +DS + D + ++ ++ +
Sbjct: 972 NSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1016
Score = 47.8 bits (112), Expect = 7e-05
Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 1/119 (0%)
Query: 365 SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQ 424
SS ++ +S D+ S+ S D SSD ++ + + + S
Sbjct: 1183 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSD 1242
Query: 425 QPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETES-SSSESEGSKPPHFSSPE 482
+ S SS S SS S+ S+ SDS+S SG+ + S S S+SEGS H +S +
Sbjct: 1243 SSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 45.8 bits (107), Expect = 3e-04
Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 20/164 (12%)
Query: 358 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLED--DLKLSSDEEENEQQAAQRTALR 415
+ DS S ++ D+ S + +SN+S D D SSD ++ + +
Sbjct: 1150 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS-- 1207
Query: 416 ALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKP 475
SDS+ + + S SS S+ S SS SSDS SS S ++SS S S
Sbjct: 1208 --SDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDS 1265
Query: 476 PHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESN 519
S +++ + N D ++S GS+SN
Sbjct: 1266 NDESDSQSKSGNGNNNGSDS--------------DSDSEGSDSN 1295
Score = 35.4 bits (80), Expect = 0.34
Identities = 126/633 (19%), Positives = 224/633 (35%), Gaps = 74/633 (11%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALS 418
+D V+ +N+ D E+ NTS + + S E + T A
Sbjct: 181 EDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQIN-SKRNGTKEAEVTPGTGEDAGL 239
Query: 419 DSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESE--GSKPP 476
D++ PS G+ GS D E+ +G DS S E + G +
Sbjct: 240 DNS--------DGSPSGNGADEDEDEGSGDDE-DEEAGNGKDSSNNSKGQEGQDHGKEDD 290
Query: 477 HFSS------------PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN- 523
H SS PE + N+ DK +K + I N S E Q N
Sbjct: 291 HDSSIGQNSDSKEYYDPEGKEDPHNEVDGDK-TSKSEENSAGIPEDNGSQRIEDTQKLNH 349
Query: 524 ----PVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAV 579
V+ + + V + + EIK R T G++G + K +
Sbjct: 350 RESKRVENRITKESETHAVGKSQDKGIEIKGP-SSGNRNITKEVGKGNEGKEDKGQHGMI 408
Query: 580 AVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADAL 639
+ V N P ++S +P + ++ G +N + + D
Sbjct: 409 LGKGNVKTQGEVV------NIEGPGQKS---EPGNKVGHSNTGSDSNSDGYD---SYDFD 456
Query: 640 GTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRG-LSRIVPKSKEFIETESSSS 698
S+ + GN+ A+ + SS +RG S +SK+ S
Sbjct: 457 DKSMQGDDPNSSDESNGNDDANSESDNNSS-------SRGDASYNSDESKDNGNGSDSKG 509
Query: 699 SSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD 758
+ DSD S+ + + ++GND K + G S + S ++ +SD
Sbjct: 510 AEDDDSDSTSDTNNSDSN------GNGNNGNDDNDKSDSGKGKS-DSSDSDSSDSSNSSD 562
Query: 759 IAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPA 818
+ + + S SD S D + S + S+ +
Sbjct: 563 SSDSSDSD------SSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616
Query: 819 TKDSESAPPSHTSDTPAEKALPK--SKRKRKCDNED--DYREIKKSQGEKDS--SSRLAT 872
+ S+S S S++ + + K S D+ D D + S DS SS +
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676
Query: 873 STSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSL 932
S+S++ S+N + + +S + +++ S S SD+S S + SS + NS
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS----DSSNSNSSDSDSSNSS 732
Query: 933 FTSASSSKKPKADSQLQPHGGDLTKAAHNNSEN 965
+S SS+ +DS + D + ++ +++ +
Sbjct: 733 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSS 765
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 70.1 bits (170), Expect = 1e-11
Identities = 129/585 (22%), Positives = 200/585 (34%), Gaps = 92/585 (15%)
Query: 287 TSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPP------- 339
T +G + P A A A +K P++ ES S E++ EE L
Sbjct: 310 TPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS 369
Query: 340 -LSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLS 398
+ A AP K P K P G P A+ E+D + S
Sbjct: 370 QVGAASAPAKESPRKGAAP------APPGKTGPAVAKAQ----------AGKREEDSQSS 413
Query: 399 SDEEENEQQAAQRTA-------LRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 451
S+E ++E++A + +RA S A P K +++
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Query: 452 DSESSSG-SDSETESSSSESEGSKPPHFSSPEAEPASS-NKWQLDKWL-----NKVNPHK 504
DS SSS SDS+ E+ ++ + P SP+ +PAS+ L K KV P
Sbjct: 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 505 PPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKA 564
P + SES+ + D G+VP P+ +EK + + + + A
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSD----GEVPTAVAPA-QEKSLGNILQAKPTSSPA--- 585
Query: 565 PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDG 624
KG QK+ P AV V +KP +E +S
Sbjct: 586 ---KGPPQKAGPVAVQV--------------------------KAEKPMDNSE-SSEESS 615
Query: 625 ANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIV 684
+ E PAA A + TK P N + K V + R G +
Sbjct: 616 DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 675
Query: 685 PKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA----ANG 740
S + + + S S ES+ EE A TV + S G ++K A+ +
Sbjct: 676 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 735
Query: 741 GSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLL 800
G G + T + + E +E +E DS+E + ++ ++
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQED---------SESSEEESDSEEAAASPAQVKTSVK 786
Query: 801 SRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRK 845
P AP+ K + SAP + K SK K
Sbjct: 787 K---TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK 828
Score = 64.7 bits (156), Expect = 5e-10
Identities = 154/755 (20%), Positives = 255/755 (33%), Gaps = 127/755 (16%)
Query: 151 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 209
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 210 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 257
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 258 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 317
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 318 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 376
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 377 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 430
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 431 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 489
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 969
Query: 490 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 544
P P Q ++ SES + + + +D P +R
Sbjct: 970 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 545 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVS---AAAPP 589
+ PR A KA S G KQ+ P V AV A +P
Sbjct: 1019 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 590 PAVPCAPAEN----APAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVV 645
A N P + A K P + + D ++ + A +V
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLV 1135
Query: 646 PPEPTKTRPCGNNRASHRKE----LRSSVTCEKRRTRGL----SRIVPKSKEFIETESSS 697
P P++T A+ E S T GL S+ + + + S S
Sbjct: 1136 GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS 1195
Query: 698 SSSSSDSDLESEQEEYPLSKA-----QTVAASASSGNDQRLKEAAANGGSGPRAPVGSIN 752
S+ ++ D + +QE P A +T A+SG + G P+A ++
Sbjct: 1196 STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQ 1255
Query: 753 ARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPG 812
+ T + + P+ NE ++++ VK+ L + + +
Sbjct: 1256 SNITQCLLGQ---------PWPLNEA--------QVQASVVKV---LTELLEQERKKVVD 1295
Query: 813 VLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRK 847
+ K ES + D PA + P+SK+K+K
Sbjct: 1296 TTKESSRKGWESRKRKLSGDQPAART-PRSKKKKK 1329
Score = 63.2 bits (152), Expect = 2e-09
Identities = 170/927 (18%), Positives = 312/927 (33%), Gaps = 107/927 (11%)
Query: 99 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 158
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 159 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 218
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 219 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 278
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 279 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 330
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 331 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 389
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 390 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 440
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 441 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 498
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 499 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 551
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 552 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 608
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 609 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 664
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 665 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 724
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 725 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 783
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 784 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 843
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 844 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 903
+ K D+ E S GE ++ A I I ++ N RS
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSA-------------QVIKPPLIFVDPN----RS 967
Query: 904 PISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNS 963
P P + ++ + +S+ + ++A SS D + P LT N
Sbjct: 968 PAGPAATPAQAQ------AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 964 ENIPLHKSRPQTKPWSPGSNGHRDCKR 990
+P R K G++ ++ R
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSR 1048
Score = 58.9 bits (141), Expect = 3e-08
Identities = 191/993 (19%), Positives = 335/993 (33%), Gaps = 151/993 (15%)
Query: 246 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 303
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 304 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 363
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 364 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 419
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 420 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 478
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 479 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 538
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 539 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 592
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 593 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 650
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 651 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 707
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 708 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 765
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Query: 766 QFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESA 825
+ +E S D E+ + L I + P S+PA + A
Sbjct: 544 DSES-----SSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKP-----TSSPAKGPPQKA 592
Query: 826 PPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNM 885
P AEK + S+ + + D E + + L + N
Sbjct: 593 GPV-AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA-CPKKTNT 650
Query: 886 NINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKAD 945
++ P+ + R + S A SS G + + SS ++D
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTATSPAG----------SSPAVAGGTQRPAEDSSSSEESD 700
Query: 946 SQLQPHGGDLT--------KAAHNNSENIPLHKSRPQ-TKPWSPGSNG------------ 984
S+ + G +T K + ++P+ S Q T P PG G
Sbjct: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
Query: 985 HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFI-ECGNAM 1043
+ ++ ++ S K+ + KA+ + A A + A
Sbjct: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
Query: 1044 EQGPMESKSPYTMYSETVELIR-----------YAMRLKTHSGP---NATPEDKQLAALC 1089
++ P + K P + L R A + +GP + + E++ +
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 1090 YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNP 1149
LA ++K +A + K S + AP+P G +G S +
Sbjct: 881 AETLA-------QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Query: 1150 SPASSVGSQG----SLSNASALSPSTIVSIPQR 1178
S + S G ++++A + P I P R
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 966
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 70.1 bits (170), Expect = 1e-11
Identities = 129/585 (22%), Positives = 200/585 (34%), Gaps = 92/585 (15%)
Query: 287 TSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPP------- 339
T +G + P A A A +K P++ ES S E++ EE L
Sbjct: 310 TPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS 369
Query: 340 -LSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLS 398
+ A AP K P K P G P A+ E+D + S
Sbjct: 370 QVGAASAPAKESPRKGAAP------APPGKTGPAVAKAQ----------AGKREEDSQSS 413
Query: 399 SDEEENEQQAAQRTA-------LRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 451
S+E ++E++A + +RA S A P K +++
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Query: 452 DSESSSG-SDSETESSSSESEGSKPPHFSSPEAEPASS-NKWQLDKWL-----NKVNPHK 504
DS SSS SDS+ E+ ++ + P SP+ +PAS+ L K KV P
Sbjct: 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 505 PPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKA 564
P + SES+ + D G+VP P+ +EK + + + + A
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSD----GEVPTAVAPA-QEKSLGNILQAKPTSSPA--- 585
Query: 565 PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDG 624
KG QK+ P AV V +KP +E +S
Sbjct: 586 ---KGPPQKAGPVAVQV--------------------------KAEKPMDNSE-SSEESS 615
Query: 625 ANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIV 684
+ E PAA A + TK P N + K V + R G +
Sbjct: 616 DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 675
Query: 685 PKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA----ANG 740
S + + + S S ES+ EE A TV + S G ++K A+ +
Sbjct: 676 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 735
Query: 741 GSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLL 800
G G + T + + E +E +E DS+E + ++ ++
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQED---------SESSEEESDSEEAAASPAQVKTSVK 786
Query: 801 SRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRK 845
P AP+ K + SAP + K SK K
Sbjct: 787 K---TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK 828
Score = 63.2 bits (152), Expect = 2e-09
Identities = 170/927 (18%), Positives = 312/927 (33%), Gaps = 107/927 (11%)
Query: 99 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 158
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 159 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 218
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 219 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 278
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 279 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 330
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 331 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 389
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 390 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 440
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 441 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 498
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 499 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 551
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 552 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 608
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 609 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 664
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 665 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 724
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 725 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 783
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 784 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 843
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 844 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 903
+ K D+ E S GE ++ A I I ++ N RS
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSA-------------QVIKPPLIFVDPN----RS 967
Query: 904 PISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNS 963
P P + ++ + +S+ + ++A SS D + P LT N
Sbjct: 968 PAGPAATPAQAQ------AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 964 ENIPLHKSRPQTKPWSPGSNGHRDCKR 990
+P R K G++ ++ R
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSR 1048
Score = 60.5 bits (145), Expect = 1e-08
Identities = 157/760 (20%), Positives = 259/760 (34%), Gaps = 138/760 (18%)
Query: 151 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 209
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 210 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 257
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 258 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 317
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 318 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 376
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 377 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 430
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 431 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 489
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 969
Query: 490 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 544
P P Q ++ SES + + + +D P +R
Sbjct: 970 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 545 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVS---AAAPP 589
+ PR A KA S G KQ+ P V AV A +P
Sbjct: 1019 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 590 PAVPCAPAEN----APAPARRSAGKKP-----TRRTERTSAGDGANCHRPEEPAAADALG 640
A N P + A K P + + +S+G + P+ +A LG
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG 1135
Query: 641 TSVVVPPEPTKTRPCGNNRASHRKE----LRSSVTCEKRRTRGL----SRIVPKSKEFIE 692
P P++T A+ E S T GL S+ + +
Sbjct: 1136 ------PTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDS 1189
Query: 693 TESSSSSSSSDSDLESEQEEYPLSKA-----QTVAASASSGNDQRLKEAAANGGSGPRAP 747
+ S SS+ ++ D + +QE P A +T A+SG + G P+A
Sbjct: 1190 SPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAS 1249
Query: 748 VGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHL 807
++ + T + + P+ NE ++++ VK+ L + +
Sbjct: 1250 TLALQSNITQCLLGQ---------PWPLNEA--------QVQASVVKV---LTELLEQER 1289
Query: 808 PQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRK 847
+ + K ES + D PA + P+SK+K+K
Sbjct: 1290 KKVVDTTKESSRKGWESRKRKLSGDQPAART-PRSKKKKK 1328
Score = 58.9 bits (141), Expect = 3e-08
Identities = 191/993 (19%), Positives = 335/993 (33%), Gaps = 151/993 (15%)
Query: 246 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 303
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 304 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 363
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 364 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 419
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 420 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 478
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 479 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 538
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 539 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 592
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 593 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 650
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 651 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 707
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 708 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 765
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Query: 766 QFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESA 825
+ +E S D E+ + L I + P S+PA + A
Sbjct: 544 DSES-----SSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKP-----TSSPAKGPPQKA 592
Query: 826 PPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNM 885
P AEK + S+ + + D E + + L + N
Sbjct: 593 GPV-AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA-CPKKTNT 650
Query: 886 NINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKAD 945
++ P+ + R + S A SS G + + SS ++D
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTATSPAG----------SSPAVAGGTQRPAEDSSSSEESD 700
Query: 946 SQLQPHGGDLT--------KAAHNNSENIPLHKSRPQ-TKPWSPGSNG------------ 984
S+ + G +T K + ++P+ S Q T P PG G
Sbjct: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
Query: 985 HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFI-ECGNAM 1043
+ ++ ++ S K+ + KA+ + A A + A
Sbjct: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
Query: 1044 EQGPMESKSPYTMYSETVELIR-----------YAMRLKTHSGP---NATPEDKQLAALC 1089
++ P + K P + L R A + +GP + + E++ +
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 1090 YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNP 1149
LA ++K +A + K S + AP+P G +G S +
Sbjct: 881 AETLA-------QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Query: 1150 SPASSVGSQG----SLSNASALSPSTIVSIPQR 1178
S + S G ++++A + P I P R
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 966
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 68.9 bits (167), Expect = 3e-11
Identities = 107/502 (21%), Positives = 185/502 (36%), Gaps = 60/502 (11%)
Query: 290 RGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEII-REMTWLPPLSAIQAPGK 348
R + A+ P +AK K S EE + + + + LPP A +
Sbjct: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
Query: 349 VEPTKFPFPNKDS-----QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEE 403
++ + D Q V G K P P S+ S D SS++E
Sbjct: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAP--PKKAKSSDS----DSDSSSEDEP 179
Query: 404 NEQQAAQRTALRALSDSAVVQQP-NCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSE 462
+ Q + T + + + +P + + K +SSSSSS SSSSS DSE + +
Sbjct: 180 PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
Query: 463 TESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYY 522
++ + +K P ++ SS+ +S E +
Sbjct: 240 KKTVPKKQVVAKAPVKAATTPTRKSSS--------------------SEDSSSDEEEEQK 279
Query: 523 NPVKEDVQDCGKVPDVCQP----SLREKEIKSTCKEEQRPRTANKA---PGSKGVKQKSP 575
P+K VP P SL + K +++Q ++ + S ++K P
Sbjct: 280 KPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP 339
Query: 576 PAAVAVAVSAAAPPPAVPCAPAENAPAPARRS----AGKKPTRRTERTSAGDGANCHRPE 631
P V+ + PPPA A + + + + S A KP T+ +S P
Sbjct: 340 PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPA 399
Query: 632 -EPAAADAL----GTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 686
+PAAA G ++ + + ++ + K + T + + T + +P
Sbjct: 400 VKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPA 459
Query: 687 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAA--NGGSGP 744
+ S SSSDSD S +EE + + SA Q++ AA S
Sbjct: 460 K----QAPQGSRDSSSDSDSSSSEEE-----EEKTSKSAVKKKPQKVAGGAAPSKPASAK 510
Query: 745 RAPVGSINARTTSDIAKELEEQ 766
+ S N+ ++ D ++E EE+
Sbjct: 511 KGKAESSNSSSSDDSSEEEEEK 532
Score = 64.7 bits (156), Expect = 5e-10
Identities = 144/660 (21%), Positives = 231/660 (35%), Gaps = 105/660 (15%)
Query: 127 QTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAA-VPVQQSKRGTMGWQKAGHPPSDGQQ 185
+ P K+ + +A+ + SS S +S V +K+ + ++ G PP
Sbjct: 62 KVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAA 121
Query: 186 RATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSL 245
+A++ S D Q + +Q +P A AAK PP
Sbjct: 122 KASESSSSEESSDDDDEEDQKKQP--------VQKGVKPQAKAAKA----------PPKK 163
Query: 246 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAK 305
A D + DE PK + T V + P P+PARA K
Sbjct: 164 AKSSD------------SDSDSSSEDEPPKNQKPKITPVTVKAQTKAP---PKPARAAPK 208
Query: 306 LSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVS 365
++ S S ++ EE A P K P K Q+V+
Sbjct: 209 IANGKAASSSSSSSSSSSSDDSEEE----------KAAATPKKTVPKK--------QVVA 250
Query: 366 SGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD----SA 421
P K P T +S ED SS +EE EQ+ + S SA
Sbjct: 251 KA---PVKAATTP------TRKSSSSED----SSSDEEEEQKKPMKNKPGPYSSVPPPSA 297
Query: 422 VVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGS-KPPHFSS 480
+ + T P S SS +S+SSS + + + + S+ + KPP +
Sbjct: 298 PPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP--PA 355
Query: 481 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHG---SESNQYYNPVKEDVQDCGKVPD 537
+A +SS+ D + P KP +N S+ + + P Q G
Sbjct: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG-- 413
Query: 538 VCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPA 597
Q L K S+ +EE K K V P A A+S PA
Sbjct: 414 --QKLLTRKADSSSSEEESSSSEEEKT--KKMVATTKPKATAKAALSL----------PA 459
Query: 598 ENAPAPARRSAGKKPTRRTERTS--AGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPC 655
+ AP +R S+ + +E A +P++ A A P +P +
Sbjct: 460 KQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAA-------PSKPASAKK- 511
Query: 656 GNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPL 715
G +S+ S E+ + +G P++ + T S+ ++ + + SE+EE
Sbjct: 512 GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGT-SALTAQNGKAAKNSEEEEEEK 570
Query: 716 SKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGR 775
KA V + + S ++ EAA P+A I +T + K + + PF R
Sbjct: 571 KKAAVVVSKSGSLKKRKQNEAAKEA-ETPQAK--KIKLQTPNTFPKRKKGEKRASSPFRR 627
Score = 55.5 bits (132), Expect = 3e-07
Identities = 131/638 (20%), Positives = 211/638 (33%), Gaps = 149/638 (23%)
Query: 420 SAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFS 479
SA V + + + P +K + +SS S SS+ E +++ PP +
Sbjct: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA 119
Query: 480 SPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVC 539
+ +A +SS++ ++ E +Q PV++ V+ K
Sbjct: 120 AAKASESSSSE-------------------ESSDDDDEEDQKKQPVQKGVKPQAKAAKAP 160
Query: 540 QPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAEN 599
+ + S E P K K K P V V APP PA
Sbjct: 161 PKKAKSSDSDSDSSSEDEP--------PKNQKPKITP--VTVKAQTKAPPK-----PARA 205
Query: 600 APAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGT---SVVVPPEPTK----- 651
AP A A + + +S+ D EE AAA T VV P K
Sbjct: 206 APKIANGKAASSSSSSSSSSSSDDSE-----EEKAAATPKKTVPKKQVVAKAPVKAATTP 260
Query: 652 TRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKS-------------KEFIETES--- 695
TR ++ S E K + S + P S K+ +E +
Sbjct: 261 TRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVE 320
Query: 696 SSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINART 755
SS SS +SD SE+E+ P +KA A+ + P A +
Sbjct: 321 SSEDSSDESDSSSEEEKKPPTKAVVSKATT-------------------KPPPAKKAAES 361
Query: 756 TSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLS 815
+SD + DSD S + P +P
Sbjct: 362 SSDSS-----------------------DSD--------------SSEDDEAPSKP---- 380
Query: 816 APATKDSESAPPSHTSDTPAEKALPKSKRK---------RKCDNEDDYREIKKSQGEKDS 866
A TK+S S P+ T+ +PA K K+ RK D+ E S+ EK
Sbjct: 381 AGTTKNS-SNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 867 SSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSR 926
T T A ++++P + + R S SD+S + E + S+
Sbjct: 440 KMVATTKPKATAKA--------ALSLPAKQAPQGSRDSSSD-SDSSSSEEEEEKTSKSAV 490
Query: 927 PNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHR 986
++ KP + + + + + + ++ E K + +P +P +NG
Sbjct: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTS 550
Query: 987 DCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFG 1024
Q A +E + K KA +V K G
Sbjct: 551 ALTAQN-------GKAAKNSEEEEEEKKKAAVVVSKSG 581
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 66.6 bits (161), Expect = 1e-10
Identities = 102/384 (26%), Positives = 149/384 (38%), Gaps = 61/384 (15%)
Query: 160 AVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK----QVCNVE 215
A+ V +KR + K DG +++ + G GR+ P AK + +E
Sbjct: 2294 ALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKAR---GRGRK-PSAKAKGDRAATLE 2349
Query: 216 VGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQ-----AP 270
G T E P A SS + PP K + + A +P AP
Sbjct: 2350 EGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAP 2409
Query: 271 DESPKLKSSSETSVHCTSYRGVPASKPEPARAKA-KLSKFSIPKQ-GEESR--------- 319
+ +L + + TS+ +PA++P+P +A+A + S P++ GEE+
Sbjct: 2410 EPFAELPAPA-TSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEG 2468
Query: 320 --SGETNSCVEEIIREMT-----WLPPLSAIQ------APGKVEPTKFPFPNK-DSQLV- 364
S ++ E ++ W P S + A G EP K P+P D L
Sbjct: 2469 VTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEP-KAPWPKATDGDLAQ 2527
Query: 365 ----------SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSD----------EEEN 404
S +P K AE + + S++S SS EEE
Sbjct: 2528 EPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEG 2587
Query: 405 EQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETE 464
++ + SA + S SS SSSSSSS SSSSSS S SSS S S +
Sbjct: 2588 DKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647
Query: 465 SSSSESEGSKPPHFSSPEAEPASS 488
SSSS S S SS + +SS
Sbjct: 2648 SSSSSSSSSSSSSSSSSSSSSSSS 2671
Score = 38.9 bits (89), Expect = 0.031
Identities = 91/447 (20%), Positives = 151/447 (33%), Gaps = 63/447 (14%)
Query: 589 PPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAA----------ADA 638
PP AE +PA SA ++ + ++ T G EEP A A A
Sbjct: 2281 PPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGRGRKPSAKA 2340
Query: 639 LGTSVVV-----PPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIET 693
G P + + P +S +S +R + PK++
Sbjct: 2341 KGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKA-----PKARPAPPQ 2395
Query: 694 ESSSSSSSSDSDLESEQEEYP-----LSKAQTVAASASSGNDQRLKEAAANGGSGPRAP- 747
S + + + E P L+ A + A+ ++ + A +G GPR P
Sbjct: 2396 PSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPG 2455
Query: 748 ------VGSINARTTSDIAKELEEQFYTLVPFGRN------ELLS-----PLKDSDEIRS 790
V + TS +K+ +E G LLS P S E ++
Sbjct: 2456 EEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKA 2515
Query: 791 LWVKIDLTLLSRIP--------EHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKS 842
W K L++ P P+ P A A +D S +S + + S
Sbjct: 2516 PWPKATDGDLAQEPGPGLTFEDSGNPKSPD--KAQAEQDGAEESESSSSSSSGSSSSSSS 2573
Query: 843 KRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLR 902
+ E + K G + R ++ S+ ++ + + +S + + +
Sbjct: 2574 SSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSS 2633
Query: 903 SPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQ--------PHGGD 954
S S S +S +S +SSS + +S +S+SSS DS P G
Sbjct: 2634 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGP 2693
Query: 955 LTKAAHNNSENIPLHKSRPQTKPWSPG 981
+AA K+RP SPG
Sbjct: 2694 SAQAALPTKATKQAGKARPSAH--SPG 2718
Score = 34.3 bits (77), Expect = 0.77
Identities = 36/138 (26%), Positives = 50/138 (36%), Gaps = 24/138 (17%)
Query: 584 SAAAPPPAVPCAPA-------ENAPAPARRSAG-----KKPTRRTERTSAGDGANCHRPE 631
SAAAP P V APA + P R+ AG K P ++ + AG GA P
Sbjct: 2008 SAAAPAP-VSTAPATKTSRCAKGGPLSPRKDAGRAKDRKDPRKKKKGKEAGPGAGLPPPR 2066
Query: 632 EPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFI 691
PA P + + A+ R + ++ K+ RG V K E +
Sbjct: 2067 APAL-----------PSEARAPHASSLTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESM 2115
Query: 692 ETESSSSSSSSDSDLESE 709
E + S E E
Sbjct: 2116 AAEEDFEPNQDSSFSEDE 2133
Score = 33.9 bits (76), Expect = 1.00
Identities = 97/507 (19%), Positives = 174/507 (34%), Gaps = 77/507 (15%)
Query: 256 PTAYVR--PMDGQDQAPDESPKL------KSSSETSVHCTSYR--GVPASKPEPARAKAK 305
P +++R P D + Q + SP L + S +TS + G S+ A+A+ +
Sbjct: 2273 PLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGR 2332
Query: 306 LSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDS-QLV 364
K S +G+ + + E + +E+ P +EP+ P K + V
Sbjct: 2333 GRKPSAKAKGDRAATLEEGNPTDEVP------------STPLALEPSSTPGSKKSPPEPV 2380
Query: 365 SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQ 424
PK A P+ + TS E A +L+ + ++
Sbjct: 2381 DKRAKAPKARPAPPQPSPAPPAFTSC-----------PAPEPFAELPAPATSLAPAPLIT 2429
Query: 425 QPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE 484
P R ++ + S + G ++E D E +S SK + E
Sbjct: 2430 MPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPK----SKKAKEALLLRE 2485
Query: 485 PASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 544
+ WQ K L + + P + GS + P D G + P L
Sbjct: 2486 DPGAGGWQEPKSLLSLGSYPP-------AAGSSEPKAPWPKATD----GDLAQEPGPGL- 2533
Query: 545 EKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPA 604
T ++ P++ +KA + ++S ++ + + S+++ + +
Sbjct: 2534 ------TFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSS--------------SSS 2573
Query: 605 RRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 664
S+G + E GDG +AA + S + + ++ +S
Sbjct: 2574 SSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSS 2633
Query: 665 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSS----DSDLESEQEEYPLSKAQT 720
SS + + S S + SSSSSSSS DS S+ E P A T
Sbjct: 2634 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAP---APT 2690
Query: 721 VAASASSGNDQRLKEAAANGGSGPRAP 747
SA + + + A +P
Sbjct: 2691 AGPSAQAALPTKATKQAGKARPSAHSP 2717
Score = 31.2 bits (69), Expect = 6.5
Identities = 36/190 (18%), Positives = 67/190 (35%), Gaps = 8/190 (4%)
Query: 565 PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDG 624
P + + K+P A P P + + N +P + A + +E +S+
Sbjct: 2506 PAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSS 2565
Query: 625 ANCHRPEEPAAADALGTSVVVPPEPTKTRP--CGN---NRASHRKELRSSVTCEKRRTRG 679
+ +++ + G+ E K CG N ++ S + +
Sbjct: 2566 GSS---SSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSS 2622
Query: 680 LSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAAN 739
S S + SSSSSSSS S S S + + ++S+SS +++
Sbjct: 2623 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSD 2682
Query: 740 GGSGPRAPVG 749
+ P G
Sbjct: 2683 DEAAPAPTAG 2692
>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 [Homo sapiens]
Length = 568
Score = 65.1 bits (157), Expect = 4e-10
Identities = 99/395 (25%), Positives = 147/395 (37%), Gaps = 66/395 (16%)
Query: 404 NEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET 463
N + +R L+A D PN R+ SS SSSSSSS SSSSSS S SSS S S +
Sbjct: 126 NPTEDFRRKLLKAGGD------PN-RSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 178
Query: 464 ESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN 523
SSSS S S FS P L K + KP +S ++ +
Sbjct: 179 SSSSSSSSSSSSTSFSKPHK-------------LMKEHKEKP---------SKDSREHKS 216
Query: 524 PVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPG--SKGVKQKSPPAAVAV 581
KE +D K + S + KE K +E+ P+ A K P SK K S +
Sbjct: 217 AFKEPSRDHNKSSK--ESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITS 274
Query: 582 AVSAAAPPPAVPCAPAENAPAPARR---------------------SAGKKPTRRTERTS 620
AP P + +E A R+ SA KK +
Sbjct: 275 GQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVK 334
Query: 621 AGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNR--------ASHRKELRSSVTC 672
G E + +V P + +++ AS SS T
Sbjct: 335 MGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTP 394
Query: 673 EKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSK--AQTVAASASSGND 730
+ R +G R + K + E S D+D +SE E P+++ +++ S S G+D
Sbjct: 395 SQTRQQGPLRSIMKDLHSDDNE-EESDEVEDNDNDSEMER-PVNRGGSRSRRVSLSDGSD 452
Query: 731 QRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 765
A++ P P+ N ++ +++
Sbjct: 453 SESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQ 487
Score = 38.5 bits (88), Expect = 0.041
Identities = 70/327 (21%), Positives = 129/327 (39%), Gaps = 49/327 (14%)
Query: 228 AAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCT 287
++ SSS + S +S S T++ +P + K K S ++ H +
Sbjct: 162 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEH-----KEKPSKDSREHKS 216
Query: 288 SYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPP-------- 339
+++ EP+R K SK S K E E E+I+ +M + P
Sbjct: 217 AFK-------EPSRDHNKSSKESSKKPKENKPLKE-----EKIVPKMAFKEPKPMSKEPK 264
Query: 340 -----LSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNG-------TSN 387
L+ K P+K P P DS+ +S+ +A +S + +++
Sbjct: 265 PDSNLLTITSGQDKKAPSKRP-PISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSAD 323
Query: 388 TSMLEDD--LKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG 445
++D +K+ + E+E +++ L D + PN + V + S S S
Sbjct: 324 KKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDD---IVDPN-DSDVEENISSKSDSEQP 379
Query: 446 SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE----PASSNKWQLDKWLNKVN 501
S +SSS S SSS + S+T K H E E + N ++++ +N+
Sbjct: 380 SPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGG 439
Query: 502 PHKPPILIQNESHGSESNQYYNPVKED 528
+ + + S SES+ +P+ +
Sbjct: 440 SRSRRVSLSDGS-DSESSSASSPLHHE 465
Score = 36.6 bits (83), Expect = 0.15
Identities = 58/242 (23%), Positives = 90/242 (37%), Gaps = 43/242 (17%)
Query: 248 KPSLVQQKPTAYVRPM-DGQDQ-APDESPKLKSSSETSVH----------CTSYRGVPAS 295
KP + KP + + + GQD+ AP + P + S E S S+ P
Sbjct: 257 KPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPL 316
Query: 296 KPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFP 355
+ K ++ S K G+ ET+ ++ + LPP I P
Sbjct: 317 ILTCSADKKQIKDKSHVKMGKVKIESETSE------KKKSTLPPFDDIVDPN-------- 362
Query: 356 FPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALR 415
DS + N K D+E SP + +S++S S + QQ R+ ++
Sbjct: 363 ----DSDVEE---NISSKSDSEQPSPASSSSSSSS-------SFTPSQTRQQGPLRSIMK 408
Query: 416 AL-SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSK 474
L SD + + S+ + GS S S GSDSE+ S+SS
Sbjct: 409 DLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSL--SDGSDSESSSASSPLHHEP 466
Query: 475 PP 476
PP
Sbjct: 467 PP 468
Score = 32.7 bits (73), Expect = 2.2
Identities = 64/272 (23%), Positives = 103/272 (37%), Gaps = 26/272 (9%)
Query: 691 IETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGS 750
I T SSSSSSSS S S S + + ++S+SS + +++ S P +
Sbjct: 146 IHTSSSSSSSSSSSSSSSSSSS---SSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKE 202
Query: 751 INARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE 810
+ + D ++E + F K E + L + +P+ +E
Sbjct: 203 HKEKPSKD-SREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEE------KIVPKMAFKE 255
Query: 811 PGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNED-DYREIKKSQGE---KDS 866
P +S DS + D A SKR D+E+ ++ KKS E K
Sbjct: 256 PKPMSKEPKPDSNLLTITSGQDKKA-----PSKRPPISDSEELSAKKRKKSSSEALFKSF 310
Query: 867 SSR----LATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDA--SKHKYTSED 920
SS L S + ++ + V I +EK +S + P D E+
Sbjct: 311 SSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKK-KSTLPPFDDIVDPNDSDVEEN 369
Query: 921 LTSSSRPNGNSLFTSASSSKKPKADSQLQPHG 952
++S S S +S+SSS SQ + G
Sbjct: 370 ISSKSDSEQPSPASSSSSSSSSFTPSQTRQQG 401
Score = 32.3 bits (72), Expect = 2.9
Identities = 41/191 (21%), Positives = 75/191 (39%), Gaps = 16/191 (8%)
Query: 843 KRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLR 902
+RK D R I S SSS ++S+S++ S++ + + +S + + +
Sbjct: 132 RRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSST 191
Query: 903 SPISPLSDASKHKY-----TSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTK 957
S P +HK + E ++ P+ + +S SSKKPK + L+
Sbjct: 192 SFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLK-------- 243
Query: 958 AAHNNSENIPLHKSRPQTKPWSPGSN--GHRDCKRQKLVFDDMPRSADYFMQEAKRMKHK 1015
+ + +P +K P SN + +K P S + KR K
Sbjct: 244 -EEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSS 302
Query: 1016 ADAMVEKFGKA 1026
++A+ + F A
Sbjct: 303 SEALFKSFSSA 313
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 65.1 bits (157), Expect = 4e-10
Identities = 180/990 (18%), Positives = 333/990 (33%), Gaps = 122/990 (12%)
Query: 99 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 158
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 159 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 218
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 219 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 278
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 279 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 330
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 331 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 389
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 390 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 440
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 441 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 498
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 499 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 551
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 552 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 608
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 609 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 664
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 665 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 724
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 725 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 783
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 784 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 843
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 844 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 903
+ K D+ E S GE ++ A I I ++ N RS
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSA-------------QVIKPPLIFVDPN----RS 967
Query: 904 PISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNS 963
P P + ++ + +S+ + ++A SS D + P LT N
Sbjct: 968 PAGPAATPAQAQ------AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 964 ENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKF 1023
+P R K G++ ++ R + + K+ + A + +K
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSR---------------ISDGKKQEGPATQVSKKN 1066
Query: 1024 GKALNYAEAALSFIECGNAMEQGPMESKSP 1053
+L +AAL + + Q P+ P
Sbjct: 1067 PASLPLTQAALKVLAQKASEAQPPVARTQP 1096
Score = 60.1 bits (144), Expect = 1e-08
Identities = 129/598 (21%), Positives = 204/598 (34%), Gaps = 115/598 (19%)
Query: 151 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 209
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 210 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 257
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 258 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 317
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 318 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 376
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 377 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 430
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 431 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 489
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 969
Query: 490 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 544
P P Q ++ SES + + + +D P +R
Sbjct: 970 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 545 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVSAAAPPPAV 592
+ PR A KA S G KQ+ P V + P ++
Sbjct: 1019 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV-----SKKNPASL 1070
Query: 593 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKT 652
P A + S + P RT+ +S D A+GT P+ T
Sbjct: 1071 PLTQAALKVLAQKASEAQPPVARTQPSSGVD-------------SAVGTLPATSPQSTSV 1117
Query: 653 RPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQ 710
+ G N+ LR E ++ + P+S + E +SS SSS S+ D E Q
Sbjct: 1118 QAKGTNK------LRKPKLPEVQQ----ATKAPESSDDSE-DSSDSSSGSEEDGEGPQ 1164
Score = 58.9 bits (141), Expect = 3e-08
Identities = 191/993 (19%), Positives = 335/993 (33%), Gaps = 151/993 (15%)
Query: 246 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 303
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 304 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 363
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 364 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 419
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 420 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 478
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 479 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 538
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 539 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 592
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 593 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 650
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 651 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 707
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 708 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 765
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Query: 766 QFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESA 825
+ +E S D E+ + L I + P S+PA + A
Sbjct: 544 DSES-----SSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKP-----TSSPAKGPPQKA 592
Query: 826 PPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNM 885
P AEK + S+ + + D E + + L + N
Sbjct: 593 GPV-AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA-CPKKTNT 650
Query: 886 NINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKAD 945
++ P+ + R + S A SS G + + SS ++D
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTATSPAG----------SSPAVAGGTQRPAEDSSSSEESD 700
Query: 946 SQLQPHGGDLT--------KAAHNNSENIPLHKSRPQ-TKPWSPGSNG------------ 984
S+ + G +T K + ++P+ S Q T P PG G
Sbjct: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
Query: 985 HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFI-ECGNAM 1043
+ ++ ++ S K+ + KA+ + A A + A
Sbjct: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
Query: 1044 EQGPMESKSPYTMYSETVELIR-----------YAMRLKTHSGP---NATPEDKQLAALC 1089
++ P + K P + L R A + +GP + + E++ +
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 1090 YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNP 1149
LA ++K +A + K S + AP+P G +G S +
Sbjct: 881 AETLA-------QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Query: 1150 SPASSVGSQG----SLSNASALSPSTIVSIPQR 1178
S + S G ++++A + P I P R
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 966
Score = 40.4 bits (93), Expect = 0.011
Identities = 61/251 (24%), Positives = 96/251 (38%), Gaps = 40/251 (15%)
Query: 266 QDQAPDESPKLKSSSETSVHCTSYRGV--------PASKPE-PARAKAKLSKFSIPKQGE 316
QD + S + S E TS + + P P PA A+ S P++
Sbjct: 929 QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKAR 988
Query: 317 ES----RSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFP-----------FPNKDS 361
S RS + S E++I L P I+ PT P +K+S
Sbjct: 989 ASESTARSSSSESEDEDVIPATQCLTP--GIRTNVVTMPTAHPRIAPKASMAGASSSKES 1046
Query: 362 QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSA 421
+S G ++G A S N S + + LK+ + + Q RT + DSA
Sbjct: 1047 SRISDGKK--QEGPATQVSKKNPAS-LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSA 1103
Query: 422 VVQQP--NCRTSVPSSKGSSS---------SSSSGSSSSSSDSESSSGSDSETESSSSES 470
V P + +++ +KG++ ++ + SS DSE SS S S +E
Sbjct: 1104 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGP 1163
Query: 471 EGSKPPHFSSP 481
+G+K H P
Sbjct: 1164 QGAKSAHTLGP 1174
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 63.5 bits (153), Expect = 1e-09
Identities = 116/647 (17%), Positives = 225/647 (34%), Gaps = 78/647 (12%)
Query: 378 PESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKG 437
P S G + +K+ S+E+ + +++ + + ++ V +
Sbjct: 419 PFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT---EETQVTEEVTEEEE 475
Query: 438 SSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWL 497
+ G + E + G + ET+S +E +SPE E S K +
Sbjct: 476 KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEA-------ASPEKEAKSPVKEEAKSPA 528
Query: 498 NKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQR 557
+P K E E + +P KE+ + P+ P E + + K ++
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKAK--SPAKEEAK---SPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 558 PRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPAR-------RSAGK 610
++ K + KSP A + A P E A +PA +S K
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK 643
Query: 611 KPTRRTERTSAGDGANCHRPEE---PAAADALGTSVVVPPEPTKTRPCGNNRASHRKELR 667
+ + E+ + + PE+ P A+A P + + ++ ++E +
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 668 SSVTCE---KRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 724
S + K + + KE +T + S + E+ + P KA+T+
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-EKAKTL--- 759
Query: 725 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPF----------- 773
D + EA R+P + S + +E++ P
Sbjct: 760 -----DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEI 814
Query: 774 -GRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSD 832
+ E+ SP+K+ ++ + + VK P++ APAT +E S +
Sbjct: 815 PKKEEVKSPVKEEEKPQEVKVK-----------EPPKKAEEEKAPATPKTEEKKDSKKEE 863
Query: 833 TPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAI 892
P ++A PK K + K + + + K + +K+ + + A + + A
Sbjct: 864 APKKEA-PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEA-PAKVEVKEDAK 921
Query: 893 PINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHG 952
P K E + P D +K K S+ +A K K + +P
Sbjct: 922 PKEKTEVAKKEP-----DDAKAKEPSKPAEKKE---------AAPEKKDTKEEKAKKPEE 967
Query: 953 GDLTKA-AHNNSENIPLHKSRPQT-KPWSPGSNGHRDCKRQKLVFDD 997
T+A A + + + S+P+ K S +D K + +D
Sbjct: 968 KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 42.4 bits (98), Expect = 0.003
Identities = 90/465 (19%), Positives = 157/465 (33%), Gaps = 48/465 (10%)
Query: 203 RQQPRAKQVCNVEVGLQTQERPPAMA---AKHSSSGHCVQNFPPSLASKPSLVQQKPTAY 259
+ P AK E + + P A AK + P S + P
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 260 VRPMDGQDQAPDE--SPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 317
P+ + ++P E SP+ K+ S T S + + E A++ K +K + + +
Sbjct: 619 KSPVKEEAKSPAEVKSPE-KAKSPTKEEAKSPEKAKSPEKEEAKSPEK-AKSPVKAEAKS 676
Query: 318 SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVE---------PTKFPFPNKDSQLVSSGH 368
++ E E P ++P K + P K P K+
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA 736
Query: 369 NNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNC 428
+P K +A+ SP+ S D+K S E + + R+ + A
Sbjct: 737 KSPVKEEAK--SPEKAKSPEKAKTLDVK--SPEAKTPAKEEARSPADKFPEKA------- 785
Query: 429 RTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEG------SKPPHFSSPE 482
++ V S + S + E E +S E E +PP + E
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845
Query: 483 AEPASSNKWQLDKWLNKVNPHK--PPILIQNESHGSESNQYYNPV---KEDVQDCGKVPD 537
PA+ + + P K P ++ + + + V KE+ +D KVP
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905
Query: 538 VCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAV--------SAAAPP 589
+ + + E+K K +++ A K P K+ S PA A A P
Sbjct: 906 PEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKP 965
Query: 590 PAVPC--APAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEE 632
P A A+ + K + E++S+ D + PE+
Sbjct: 966 EEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 62.8 bits (151), Expect = 2e-09
Identities = 135/626 (21%), Positives = 214/626 (34%), Gaps = 118/626 (18%)
Query: 151 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 209
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 210 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 257
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 678
Query: 258 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 317
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 679 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 735
Query: 318 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 376
+ + + ++ P S + A G P P K + P++
Sbjct: 736 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 789
Query: 377 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 430
D+G+S SD EE + AQ +RA A
Sbjct: 790 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 835
Query: 431 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 489
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 836 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 892
Query: 490 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 544
P P Q ++ SES + + + +D P +R
Sbjct: 893 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 941
Query: 545 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVSAAAPPPAV 592
+ PR A KA S G KQ+ P V + P ++
Sbjct: 942 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV-----SKKNPASL 993
Query: 593 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKT 652
P A + S + P RT+ +S D A+GT P+ T
Sbjct: 994 PLTQAALKVLAQKASEAQPPVARTQPSSGVD-------------SAVGTLPATSPQSTSV 1040
Query: 653 RPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEE 712
+ G N+ LR E ++ + P+S + E +SS SSS S+ D E Q
Sbjct: 1041 QAKGTNK------LRKPKLPEVQQ----ATKAPESSDDSE-DSSDSSSGSEEDGEGPQ-- 1087
Query: 713 YPLSKAQTVAASASSGNDQRLKEAAA 738
A T+ S + ++E AA
Sbjct: 1088 -GAKSAHTLVGPTPSRTETLVEETAA 1112
Score = 59.7 bits (143), Expect = 2e-08
Identities = 157/788 (19%), Positives = 276/788 (35%), Gaps = 108/788 (13%)
Query: 293 PASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPT 352
P K PA AKA+ K + E+S+S S EE +AP + +P+
Sbjct: 313 PPGKTGPAVAKAQAGK-----REEDSQSSSEESDSEE--------------EAPAQAKPS 353
Query: 353 -KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSML----EDDLKLSSDEEENEQQ 407
K P S + +P+KG A G + + E+D + SS+E +++++
Sbjct: 354 GKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 410
Query: 408 AA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS---SSSSGSSSSSSDSESSSGSDS 461
A ++ L S V+ + P KG+ ++ S+ + S+S
Sbjct: 411 ALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSES 470
Query: 462 ETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN--KVNPHKP-PILIQNESHGSES 518
+E SS S+G P + P E + N Q + K P K P+ +Q ++
Sbjct: 471 SSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMD 529
Query: 519 NQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQK 573
N + D D + P +P+L+ + K+ K+ +A AP G +
Sbjct: 530 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA- 588
Query: 574 SPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSAGKKPTRRT----ERTSAGDGAN 626
P A S A PAV PAE++ + + ++ T + S G G
Sbjct: 589 --PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ 646
Query: 627 CHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 686
P +LG P P KT P + ++E S E +
Sbjct: 647 VKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQV 704
Query: 687 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRA 746
+T++ ++ +++ + P K T AA A + ++K N +
Sbjct: 705 KTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763
Query: 747 PVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE 805
G + + +A + Q G +E S ++ E TL P
Sbjct: 764 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE----------TLAQVKPS 813
Query: 806 HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD 865
+ APA + +P + TP K P + + K D+ E S GE
Sbjct: 814 GKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAP 869
Query: 866 SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS 925
++ A I I ++ N RSP P + ++ + +S+
Sbjct: 870 AAVTSA-------------QVIKPPLIFVDPN----RSPAGPAATPAQAQ------AAST 906
Query: 926 RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH 985
+ ++A SS D + P LT N +P R K G++
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSS 966
Query: 986 RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ 1045
++ R + + K+ + A + +K +L +AAL + + Q
Sbjct: 967 KESSR---------------ISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQ 1011
Query: 1046 GPMESKSP 1053
P+ P
Sbjct: 1012 PPVARTQP 1019
Score = 55.1 bits (131), Expect = 4e-07
Identities = 165/828 (19%), Positives = 286/828 (34%), Gaps = 138/828 (16%)
Query: 246 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 303
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 304 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 363
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 364 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTA-LRALS 418
VS P G A +P G +++S +D SSDE + E +A+++ +RA S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEVKASEKILQVRAAS 227
Query: 419 DSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSS--GSDSETES----------- 465
A T P K + +S + + DSESSS SDSE E+
Sbjct: 228 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKA 287
Query: 466 --SSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN 523
+S+ + P SP A + + + K K Q+ S S+S +
Sbjct: 288 SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--- 344
Query: 524 PVKEDVQDCGKVPDV-----------------------------CQPSLREKEIKSTCKE 554
+ GK P V Q +E++ +S+ +E
Sbjct: 345 EAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404
Query: 555 EQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPP---PAVPCAPAENAPAPARRSAGK- 610
R A A + VK V A + P A P P + PA GK
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 611 KPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSV 670
+ + + D ++ P A A ++ +PT + G + + + V
Sbjct: 465 EEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA--GPVAVQV 522
Query: 671 TCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGND 730
EK + S+ E+ S+ S + + + + Q + L QT A +
Sbjct: 523 KAEKP--------MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 574
Query: 731 QRLKEAAAN-GGSGPR------APVGSINA-----------RTTSDIAKELEEQFYTLVP 772
K A G PR +P GS A ++S+ + EE+ V
Sbjct: 575 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 634
Query: 773 FGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE--PGVLSAPATKDSESAPPSHT 830
G+ + + ++++ V + +L LP + P V A K +S
Sbjct: 635 VGQAKSVG---KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE 691
Query: 831 SDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSV 890
SD+ A P + +KK+Q + + ++ A S T+SA + +
Sbjct: 692 SDSEEAAASPAQVK----------TSVKKTQAKANPAAARAPSAKGTISAP--GKVVTAA 739
Query: 891 AIPINKNEKMLRSPI-----------SPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSS 939
A ++ ++ P+ P S S K + + + P +S + S
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799
Query: 940 KKPKAD--SQLQPHGGDLTKAAHNNSENIPLHKS-RPQTKPWSPGSNG 984
+ +A+ +Q++P G K + P +S R P PG G
Sbjct: 800 SEEEAETLAQVKPSG----KTHQIRAALAPAKESPRKGAAPTPPGKTG 843
Score = 40.8 bits (94), Expect = 0.008
Identities = 76/348 (21%), Positives = 121/348 (34%), Gaps = 42/348 (12%)
Query: 406 QQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSS----------------SSSGSSSS 449
QQ ++ R + A +Q R S P S SS +S+ SS
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
Query: 450 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILI 509
+D SS ++ E+ + G+ PH PA+ + L+ +P K
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPH-------PATGKT--VANLLSGKSPRKSAEPS 164
Query: 510 QNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKG 569
N + SE+ + + V G S + + S T + S+
Sbjct: 165 ANTTLVSETEE-----EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEK 219
Query: 570 VKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHR 629
+ Q +A A PA P A A A ++ KP +E S+ + ++
Sbjct: 220 ILQVRAASAPAKGTPGKGATPA----PPGKAGAVASQTKAGKPEEDSE--SSSEESSDSE 273
Query: 630 PEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKE 689
E PAA L KT G A ++ R G + +
Sbjct: 274 EETPAAKALLQAKA-----SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAG 327
Query: 690 FIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA 737
E +S SSS SDS+ E+ + P KA V A+++ + K AA
Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 375
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 61.2 bits (147), Expect = 6e-09
Identities = 75/278 (26%), Positives = 107/278 (38%), Gaps = 20/278 (7%)
Query: 360 DSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLS---SDEEENEQQAAQRTALRA 416
DS+ + + + D E + D + D K SD E+ E ++ + +L A
Sbjct: 962 DSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYA 1021
Query: 417 LSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP 476
SD + +S SS SSSSSSS SSSSSS SESSS + E E ++ S PP
Sbjct: 1022 DSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPP 1081
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVP 536
P PA ++ P+ E S + P +E P
Sbjct: 1082 R-EVPVPTPAPVEVPVPERVAGS------PVTPLPEQEASPARP-AGPTEESPPSAPLRP 1133
Query: 537 DVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAP 596
P + ++RP + ++K+ + V A PPPA P P
Sbjct: 1134 ----PEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATP--P 1187
Query: 597 AENAPAPARRSAGKKPTRRTERTSAGDGANCHR--PEE 632
P PA R A + RT R D A+ + PEE
Sbjct: 1188 QAKFPGPASRKA-PRGVERTIRNLPLDHASLVKSWPEE 1224
Score = 39.7 bits (91), Expect = 0.018
Identities = 46/169 (27%), Positives = 65/169 (38%), Gaps = 27/169 (15%)
Query: 341 SAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKK-GDAEPES----PDNGTSNTSMLEDDL 395
+A+ PG P ++D+ SS + P G P+S P +T +D
Sbjct: 232 TAVGTPGNGTPC-----SQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSA 286
Query: 396 KLSSD---------EEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGS 446
SS E + Q A R A S S T+ ++ S+SSSS S
Sbjct: 287 YSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSS 346
Query: 447 SSSSSDSESSSGSDSETESSSSESEG--------SKPPHFSSPEAEPAS 487
SSSSS S SSS S + + E S PP ++ E P +
Sbjct: 347 SSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGA 395
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 60.5 bits (145), Expect = 1e-08
Identities = 148/800 (18%), Positives = 271/800 (33%), Gaps = 84/800 (10%)
Query: 99 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 158
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 159 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 218
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 219 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 278
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 279 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 330
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 331 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 389
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 390 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 440
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 441 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 498
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 499 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 551
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 552 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 608
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 609 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 664
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 665 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 724
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 725 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 783
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 784 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 843
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 844 RKRKCDNEDDYREIKKSQGE 863
+ K D+ E S GE
Sbjct: 925 QAGKQDDSGSSSEESDSDGE 944
Score = 57.0 bits (136), Expect = 1e-07
Identities = 113/540 (20%), Positives = 192/540 (35%), Gaps = 81/540 (15%)
Query: 246 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 303
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 304 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 363
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 364 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 419
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 420 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 478
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 479 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 538
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 539 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 592
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 593 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 650
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 651 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 707
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 708 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 765
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Score = 45.4 bits (106), Expect = 3e-04
Identities = 95/441 (21%), Positives = 166/441 (37%), Gaps = 43/441 (9%)
Query: 292 VPASKPEPARAKAKLSKF-----SIPKQGEESRSGETNSCV----EEIIREMTWLPPLSA 342
VP K PA A++ K+ S ++ +S GE + V E+ + + P S+
Sbjct: 524 VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS 583
Query: 343 IQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK--LSSD 400
P K P K P +N + + +S D+ + +M K L
Sbjct: 584 ---PAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP 639
Query: 401 EEENEQQAAQRTALRALSDSAV-VQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGS 459
+ + + TA ++ V Q P + S GSS + + G+ + DS SS S
Sbjct: 640 QTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES 699
Query: 460 DSETESSS-SESEGSKPPHFSSPEAEPAS-SNKWQLDKWLNKVNPHKP-PILIQNESHGS 516
DSE E + + + G + + AS K L + V P K P + Q ++
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ 759
Query: 517 ESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPP 576
E ++ + + D ++ P + S+++ + K+ A +AP +KG
Sbjct: 760 EDSE-SSEEESDSEEAAASPAQVKTSVKKTQAKAN-------PAAARAPSAKGTISAPGK 811
Query: 577 AAVAVAVSAAAPPPAV--PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPA 634
A A + P V P +N+ AR A + T+A A E+
Sbjct: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA--QAQTGPEEDSG 869
Query: 635 AADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSK------ 688
+++ S + +P G ++R+++ K R + P K
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTH-----QIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 689 -EFIETESSSSSSSSDSDLES 708
+ +S SSS SDSD E+
Sbjct: 925 QAGKQDDSGSSSEESDSDGEA 945
Score = 39.7 bits (91), Expect = 0.018
Identities = 71/341 (20%), Positives = 119/341 (34%), Gaps = 51/341 (14%)
Query: 151 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 209
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 210 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 257
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 258 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 317
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 318 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 376
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 377 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 430
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 431 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESE 471
P K S++ +G S S S SD E ++ + ++
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 60.1 bits (144), Expect = 1e-08
Identities = 129/598 (21%), Positives = 204/598 (34%), Gaps = 115/598 (19%)
Query: 151 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 209
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 210 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 257
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 678
Query: 258 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 317
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 679 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 735
Query: 318 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 376
+ + + ++ P S + A G P P K + P++
Sbjct: 736 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 789
Query: 377 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 430
D+G+S SD EE + AQ +RA A
Sbjct: 790 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 835
Query: 431 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 489
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 836 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 892
Query: 490 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 544
P P Q ++ SES + + + +D P +R
Sbjct: 893 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 941
Query: 545 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVSAAAPPPAV 592
+ PR A KA S G KQ+ P V + P ++
Sbjct: 942 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV-----SKKNPASL 993
Query: 593 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKT 652
P A + S + P RT+ +S D A+GT P+ T
Sbjct: 994 PLTQAALKVLAQKASEAQPPVARTQPSSGVD-------------SAVGTLPATSPQSTSV 1040
Query: 653 RPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQ 710
+ G N+ LR E ++ + P+S + E +SS SSS S+ D E Q
Sbjct: 1041 QAKGTNK------LRKPKLPEVQQ----ATKAPESSDDSE-DSSDSSSGSEEDGEGPQ 1087
Score = 59.7 bits (143), Expect = 2e-08
Identities = 157/788 (19%), Positives = 276/788 (35%), Gaps = 108/788 (13%)
Query: 293 PASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPT 352
P K PA AKA+ K + E+S+S S EE +AP + +P+
Sbjct: 313 PPGKTGPAVAKAQAGK-----REEDSQSSSEESDSEE--------------EAPAQAKPS 353
Query: 353 -KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSML----EDDLKLSSDEEENEQQ 407
K P S + +P+KG A G + + E+D + SS+E +++++
Sbjct: 354 GKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 410
Query: 408 AA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS---SSSSGSSSSSSDSESSSGSDS 461
A ++ L S V+ + P KG+ ++ S+ + S+S
Sbjct: 411 ALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSES 470
Query: 462 ETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN--KVNPHKP-PILIQNESHGSES 518
+E SS S+G P + P E + N Q + K P K P+ +Q ++
Sbjct: 471 SSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMD 529
Query: 519 NQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQK 573
N + D D + P +P+L+ + K+ K+ +A AP G +
Sbjct: 530 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA- 588
Query: 574 SPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSAGKKPTRRT----ERTSAGDGAN 626
P A S A PAV PAE++ + + ++ T + S G G
Sbjct: 589 --PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ 646
Query: 627 CHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 686
P +LG P P KT P + ++E S E +
Sbjct: 647 VKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQV 704
Query: 687 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRA 746
+T++ ++ +++ + P K T AA A + ++K N +
Sbjct: 705 KTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763
Query: 747 PVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE 805
G + + +A + Q G +E S ++ E TL P
Sbjct: 764 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE----------TLAQVKPS 813
Query: 806 HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD 865
+ APA + +P + TP K P + + K D+ E S GE
Sbjct: 814 GKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAP 869
Query: 866 SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS 925
++ A I I ++ N RSP P + ++ + +S+
Sbjct: 870 AAVTSA-------------QVIKPPLIFVDPN----RSPAGPAATPAQAQ------AAST 906
Query: 926 RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH 985
+ ++A SS D + P LT N +P R K G++
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSS 966
Query: 986 RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ 1045
++ R + + K+ + A + +K +L +AAL + + Q
Sbjct: 967 KESSR---------------ISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQ 1011
Query: 1046 GPMESKSP 1053
P+ P
Sbjct: 1012 PPVARTQP 1019
Score = 55.1 bits (131), Expect = 4e-07
Identities = 165/828 (19%), Positives = 286/828 (34%), Gaps = 138/828 (16%)
Query: 246 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 303
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 304 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 363
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 364 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTA-LRALS 418
VS P G A +P G +++S +D SSDE + E +A+++ +RA S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEVKASEKILQVRAAS 227
Query: 419 DSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSS--GSDSETES----------- 465
A T P K + +S + + DSESSS SDSE E+
Sbjct: 228 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKA 287
Query: 466 --SSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN 523
+S+ + P SP A + + + K K Q+ S S+S +
Sbjct: 288 SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--- 344
Query: 524 PVKEDVQDCGKVPDV-----------------------------CQPSLREKEIKSTCKE 554
+ GK P V Q +E++ +S+ +E
Sbjct: 345 EAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404
Query: 555 EQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPP---PAVPCAPAENAPAPARRSAGK- 610
R A A + VK V A + P A P P + PA GK
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 611 KPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSV 670
+ + + D ++ P A A ++ +PT + G + + + V
Sbjct: 465 EEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA--GPVAVQV 522
Query: 671 TCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGND 730
EK + S+ E+ S+ S + + + + Q + L QT A +
Sbjct: 523 KAEKP--------MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 574
Query: 731 QRLKEAAAN-GGSGPR------APVGSINA-----------RTTSDIAKELEEQFYTLVP 772
K A G PR +P GS A ++S+ + EE+ V
Sbjct: 575 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 634
Query: 773 FGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE--PGVLSAPATKDSESAPPSHT 830
G+ + + ++++ V + +L LP + P V A K +S
Sbjct: 635 VGQAKSVG---KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE 691
Query: 831 SDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSV 890
SD+ A P + +KK+Q + + ++ A S T+SA + +
Sbjct: 692 SDSEEAAASPAQVK----------TSVKKTQAKANPAAARAPSAKGTISAP--GKVVTAA 739
Query: 891 AIPINKNEKMLRSPI-----------SPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSS 939
A ++ ++ P+ P S S K + + + P +S + S
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799
Query: 940 KKPKAD--SQLQPHGGDLTKAAHNNSENIPLHKS-RPQTKPWSPGSNG 984
+ +A+ +Q++P G K + P +S R P PG G
Sbjct: 800 SEEEAETLAQVKPSG----KTHQIRAALAPAKESPRKGAAPTPPGKTG 843
Score = 40.8 bits (94), Expect = 0.008
Identities = 76/348 (21%), Positives = 121/348 (34%), Gaps = 42/348 (12%)
Query: 406 QQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSS----------------SSSGSSSS 449
QQ ++ R + A +Q R S P S SS +S+ SS
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
Query: 450 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILI 509
+D SS ++ E+ + G+ PH PA+ + L+ +P K
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPH-------PATGKT--VANLLSGKSPRKSAEPS 164
Query: 510 QNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKG 569
N + SE+ + + V G S + + S T + S+
Sbjct: 165 ANTTLVSETEE-----EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEK 219
Query: 570 VKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHR 629
+ Q +A A PA P A A A ++ KP +E S+ + ++
Sbjct: 220 ILQVRAASAPAKGTPGKGATPA----PPGKAGAVASQTKAGKPEEDSE--SSSEESSDSE 273
Query: 630 PEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKE 689
E PAA L KT G A ++ R G + +
Sbjct: 274 EETPAAKALLQAKA-----SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAG 327
Query: 690 FIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA 737
E +S SSS SDS+ E+ + P KA V A+++ + K AA
Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 375
Score = 40.4 bits (93), Expect = 0.011
Identities = 61/251 (24%), Positives = 96/251 (38%), Gaps = 40/251 (15%)
Query: 266 QDQAPDESPKLKSSSETSVHCTSYRGV--------PASKPE-PARAKAKLSKFSIPKQGE 316
QD + S + S E TS + + P P PA A+ S P++
Sbjct: 852 QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKAR 911
Query: 317 ES----RSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFP-----------FPNKDS 361
S RS + S E++I L P I+ PT P +K+S
Sbjct: 912 ASESTARSSSSESEDEDVIPATQCLTP--GIRTNVVTMPTAHPRIAPKASMAGASSSKES 969
Query: 362 QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSA 421
+S G ++G A S N S + + LK+ + + Q RT + DSA
Sbjct: 970 SRISDGKK--QEGPATQVSKKNPAS-LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSA 1026
Query: 422 VVQQP--NCRTSVPSSKGSSS---------SSSSGSSSSSSDSESSSGSDSETESSSSES 470
V P + +++ +KG++ ++ + SS DSE SS S S +E
Sbjct: 1027 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGP 1086
Query: 471 EGSKPPHFSSP 481
+G+K H P
Sbjct: 1087 QGAKSAHTLGP 1097
>gi|169166609 PREDICTED: similar to ribonucleic acid binding protein
S1 isoform 6 [Homo sapiens]
Length = 305
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 591
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 592 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|113415994 PREDICTED: similar to ribonucleic acid binding protein
S1 isoform 2 [Homo sapiens]
Length = 305
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 591
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 592 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|113415504 PREDICTED: similar to ribonucleic acid binding protein
S1 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 591
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 592 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|169166499 PREDICTED: similar to ribonucleic acid binding protein
S1 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 591
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 592 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|113415498 PREDICTED: similar to ribonucleic acid binding protein
S1 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 591
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 592 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|88973230 PREDICTED: similar to ribonucleic acid binding protein
S1 isoform 3 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 591
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 592 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 58.9 bits (141), Expect = 3e-08
Identities = 67/236 (28%), Positives = 102/236 (43%), Gaps = 36/236 (15%)
Query: 357 PNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRA 416
P K+ + SS ++ + S + +S+ S SSD E + AL+
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSS-------SSDSEGSSLPVQPEVALKR 2578
Query: 417 LSDSAVVQQPNCRTSVP-------------SSKGSSSSSSSGSSSSSSDSESSSGSDSET 463
+ + R P SS SSSSSSS SSSSSS S SSS S S +
Sbjct: 2579 VPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2638
Query: 464 ESSSSESEGSKPPHFSSPEA--EPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQY 521
SSSS S S P P+A +PAS K + ++ +P KP +S +
Sbjct: 2639 SSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSR-SPRKP-----IDSLRDSRSLS 2692
Query: 522 YNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQR-PRTANKAPGSKGVKQKSPP 576
Y+PV+ + P QPS R+++ S+ + +R R +++P K ++ P
Sbjct: 2693 YSPVER------RRPSP-QPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSP 2741
Score = 58.5 bits (140), Expect = 4e-08
Identities = 118/497 (23%), Positives = 187/497 (37%), Gaps = 81/497 (16%)
Query: 223 RPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSET 282
R PA A S +G PP+ A+ PS + + G A +P + S T
Sbjct: 2301 RTPAALAALSLTG---SGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRT 2357
Query: 283 SVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSA 342
+ + + +++ PA + A L+ +P E SG T+ + + R T PP +
Sbjct: 2358 AA-ALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRT--PPSAP 2414
Query: 343 IQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT---------SNTSMLED 393
Q+ ++ + P P+ S P D +P SP + T+ +
Sbjct: 2415 SQS--RMTSERAPSPSSRMGQAPSQSLLPPAQD-QPRSPVPSAFSDQSRCLIAQTTPVAG 2471
Query: 394 DLKLSSDE-EENEQQAAQRTALRALSDSAV-------------VQQPNCRTSVPSSKGSS 439
LSS A + ++ V QQP+ ++ +K
Sbjct: 2472 SQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERR 2531
Query: 440 SSSSSGSSSSSSDSESSSGSDSETE-SSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 498
SSSSS SSSSSS S SSS S S + SSSS+SEGS P PE L
Sbjct: 2532 SSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP--VQPEVA------------LK 2577
Query: 499 KVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRP 558
+V P KE V++ G+ P+ P+ R++ S+
Sbjct: 2578 RVPSPTP------------------APKEAVRE-GRPPEP-TPAKRKRRSSSSSSSSSSS 2617
Query: 559 RTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTER 618
+++ + S S ++ + + S+++ P +PA+ P + A K ER
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP----SPAKPGPQALPKPASPKKPPPGER 2673
Query: 619 TSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTR 678
S P +P D+L S + P + R + ++ SS +R R
Sbjct: 2674 RS-------RSPRKP--IDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQR 2724
Query: 679 GLSRIVPKSKEFIETES 695
G SR P K ET S
Sbjct: 2725 GDSR-SPSHKRRRETPS 2740
Score = 56.6 bits (135), Expect = 1e-07
Identities = 163/798 (20%), Positives = 275/798 (34%), Gaps = 93/798 (11%)
Query: 241 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPA--SKPE 298
F L + PSL ++ + + +PD K SS S+ VP S+
Sbjct: 1359 FLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRER 1418
Query: 299 PARAKAKLSKFSIPKQ-GEESRSGETNSCVEEIIREMTWLPPLSAIQ--APGKVEPTKFP 355
+ A + K +P+ SRSG + +R+ + P ++ +PG + + P
Sbjct: 1419 SSSASSPEMKDGLPRTPSRRSRSGSSPG-----LRDGSGTPSRHSLSGSSPGMKDIPRTP 1473
Query: 356 FPNKDSQLVSSGHNN--PKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTA 413
+ S+ SS P+ SP + N L + S E +Q+ RT
Sbjct: 1474 SRGR-SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTP 1532
Query: 414 L----------------------RALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 451
L R+ SDS+ + RT + S SS S S S
Sbjct: 1533 LGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLS 1592
Query: 452 DSESSSGSDSETES-------SSSESEGSKPPHFSSPEAEPASSNKWQLDKW-------- 496
S SGS E + + S S+ S P +P A P S K
Sbjct: 1593 PRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGS 1652
Query: 497 -LNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEE 555
+ +P PP + GS S+ + + + P + S E+ +
Sbjct: 1653 SSTESSPEHPP-KSRTARRGSRSS-------PEPKTKSRTPPRRRSSRSSPELTRKARLS 1704
Query: 556 QRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRR 615
+R R+A+ +P + + ++PP +P + P PAE + + RR + P R
Sbjct: 1705 RRSRSASSSPET---RSRTPPR------HRRSPSVSSP-EPAEKSRSSRRRRSASSP--R 1752
Query: 616 TERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKE---LRSSVTC 672
T+ TS + +P + + + R + S R++ RS VT
Sbjct: 1753 TKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTR 1812
Query: 673 EKRRTRGLSRIVPKSKEFIETES------SSSSSSSDSDLESEQEEYPLSKAQTVAASAS 726
+R G P +E T S S + +S S P ++++ A+ A+
Sbjct: 1813 RRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPAT 1872
Query: 727 SGNDQRLKEAAANGGSGPR-APVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDS 785
+ + S R +PV +R+ + + + + V R+ +P
Sbjct: 1873 HRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTR 1932
Query: 786 DEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPAT-KDSESAPPSHTSDTPAEKALPKSKR 844
RS SR P + + P T + S S T + P ++R
Sbjct: 1933 RRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRR 1992
Query: 845 KRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSP 904
+ + R +S+ + R S S T A + +P ++ RSP
Sbjct: 1993 RSRSRTSPVTRRRSRSRTSPVTRRR---SRSRTPPAIRRRSRSRTPLLPRKRSRS--RSP 2047
Query: 905 IS-PLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQP----HGGDLTKAA 959
++ S+ T+ S +R SAS S ++ S P H G T
Sbjct: 2048 LAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPV 2107
Query: 960 HNNSENIPLHKSRPQTKP 977
NS + SRP P
Sbjct: 2108 ALNSSRMSCF-SRPSMSP 2124
Score = 48.5 bits (114), Expect = 4e-05
Identities = 139/754 (18%), Positives = 245/754 (32%), Gaps = 74/754 (9%)
Query: 230 KHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSY 289
K G ++ P K S ++K + + ++P +PK K S+ S
Sbjct: 192 KKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSP--TPKSKRKSKDKKRKRSR 249
Query: 290 RGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKV 349
PA K A S + SRS ++ + T L S A G+
Sbjct: 250 STTPAPKSRRAHRSTSADSAS---SSDTSRSRSRSAAAKT---HTTALAGRSPSPASGRR 303
Query: 350 EPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAA 409
PF + P SP+ T S +D D+++ E+ A
Sbjct: 304 GEGDAPFSEPGTTSTQ-----------RPSSPETATKQPSSPYED----KDKDKKEKSAT 348
Query: 410 QRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSE 469
+ + S + +P T + + + S ++ S + + S T S
Sbjct: 349 RPSPSPERSSTG--PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPP 406
Query: 470 SEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSES------NQYYN 523
K P SS E+ P S ++ + + +P P SH S N+ +
Sbjct: 407 KSPEKLPQSSSSESSPPSPQPTKVSRHASS-SPESPKPAPAPGSHREISSSPTSKNRSHG 465
Query: 524 PVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAV 583
K D PS R +S + R R+ ++ P +G + P
Sbjct: 466 RAKRDKSHSHT------PSRRMGRSRSPATAK-RGRSRSRTPTKRGHSRSRSPQWRR--- 515
Query: 584 SAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSV 643
S +A +P + + + G +R T+R A R + A
Sbjct: 516 SRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPA------- 568
Query: 644 VVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSD 703
TR +R R+ S T +RR+R + +S+ S S +
Sbjct: 569 --------TRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTP 620
Query: 704 SDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKEL 763
+ S P+ + + A R + A G S R P +R+ + +
Sbjct: 621 ARRRSRTRS-PVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSG 679
Query: 764 EEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSE 823
+ T GR+ +P + RSL + R PQ G + + + ++
Sbjct: 680 RSRSRTPARRGRSRSRTPRRGRSRSRSLVRR------GRSHSRTPQRRGRSGSSSERKNK 733
Query: 824 SAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHC 883
S S + + + KS+ + R S + SRL+ S + ++ C
Sbjct: 734 SRTSQRRSRSNSSPEMKKSRISSR-------RSRSLSSPRSKAKSRLSLRRSLS-GSSPC 785
Query: 884 NMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPK 943
+ P ++ P + + +S + S + +SSS PK
Sbjct: 786 PKQKSQT--PPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK 843
Query: 944 ADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKP 977
S P G +T N P +S ++ P
Sbjct: 844 VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSP 877
Score = 48.1 bits (113), Expect = 5e-05
Identities = 129/648 (19%), Positives = 226/648 (34%), Gaps = 96/648 (14%)
Query: 434 SSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQL 493
S+ GSSS S ++ ++ + S S + +SS S FS P P ++ +
Sbjct: 2079 SASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMS------CFSRPSMSPTPLDRCRS 2132
Query: 494 DKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCK 553
L + + P+ + ++ GS + + + + VP+ S + +
Sbjct: 2133 PGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRT--SVPENHAQSRIALALTAISL 2190
Query: 554 EEQRPRTANKAPGSKGVKQKSP--------------------PAAVAVAVS-AAAPPPAV 592
RP + A G + P PAA A A++ A+A PA+
Sbjct: 2191 GTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAI 2250
Query: 593 P------------CAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADAL- 639
P A A N +P A RT N PAA AL
Sbjct: 2251 PTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALS 2310
Query: 640 ----GTSVVVPPEPTKTR----PCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFI 691
GT P+ +R P N R ++ +R + + P S
Sbjct: 2311 LTGSGTPPTAANYPSSSRTPQAPASANLVGPR-SAHATAPVNIAGSRTAAALAPASL--- 2366
Query: 692 ETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGS- 750
T + + + S ++L S + PLS + V+ S R A + P AP S
Sbjct: 2367 -TSARMAPALSGANLTSPR--VPLSAYERVSGRTSPPLLDR-----ARSRTPPSAPSQSR 2418
Query: 751 -INARTTSDIAKELEEQFYTLVPFGRNELLSPLKD--SDEIRSLWVK---------IDLT 798
+ R S ++ + +L+P +++ SP+ SD+ R L + +
Sbjct: 2419 MTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSG 2478
Query: 799 LLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIK 858
++ G+LS PA P S + PA + + R
Sbjct: 2479 AVATTTSSAGDHNGMLSVPA----PGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSS 2534
Query: 859 KSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPI------------- 905
S SSS ++S+S++ S+ + + ++P+ + R P
Sbjct: 2535 SSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGR 2594
Query: 906 SPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSEN 965
P +K K S +SSS + +S +S+SSS + S + ++ + ++
Sbjct: 2595 PPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP 2654
Query: 966 IPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDM--PRSADYFMQEAKR 1011
P +P + P G R + + D + RS Y E +R
Sbjct: 2655 GPQALPKPASPKKPP--PGERRSRSPRKPIDSLRDSRSLSYSPVERRR 2700
Score = 47.8 bits (112), Expect = 7e-05
Identities = 131/690 (18%), Positives = 246/690 (35%), Gaps = 72/690 (10%)
Query: 407 QAAQRTALRALSDS-AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETES 465
++ RT R S S ++V++ + P +G S SSS + S S+ S S+S E
Sbjct: 691 RSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSE-RKNKSRTSQRRSRSNSSPEM 749
Query: 466 SSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV 525
S + SSP ++ + ++ L + L+ +P P Q S S
Sbjct: 750 KKSRISSRRSRSLSSPRSK--AKSRLSLRRSLSGSSP-CPKQKSQTPPRRSRSGSSQPKA 806
Query: 526 KEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSA 585
K + P S K K R ++ +P K VK +PP ++
Sbjct: 807 K------SRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK-VKSGTPPRQGSITSPQ 859
Query: 586 AAPPPAVPCAPA--ENAPAPARRSAGKKPTRRTERTSAGDGANCHRP--EEPAAADALGT 641
A P + E++P P +S + P+R + S+ P + P+ + +
Sbjct: 860 ANEQSVTPQRRSCFESSPDPELKS--RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQP 917
Query: 642 SVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSS 701
V P + G++ S R + RR+R +S + S S SSS
Sbjct: 918 KVKAIISPRQRSHSGSSSPS---PSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSS 974
Query: 702 SDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAK 761
D+ + K +T + SG+ + A GP S++ + +
Sbjct: 975 PDTKV----------KPETPPRQSHSGSISPYPKVKAQTPPGP-----SLSGSKSPCPQE 1019
Query: 762 ELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKD 821
+ ++ P G L + +K S + + L + P S+P +
Sbjct: 1020 KSKDSLVQSCP-GSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQ 1078
Query: 822 SESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSAN 881
S S PS S + +S+ I++ +GE +S L + +S
Sbjct: 1079 SHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSG----MSPE 1134
Query: 882 HCNMNINSVAIP-INKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSK 940
+S + P ++ N + +S + K ++ ++S P F+
Sbjct: 1135 QSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQD 1194
Query: 941 KPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWS-PGSNGHRDCKRQKLVFDDMP 999
+P E+ + K +T P G+ + K Q +P
Sbjct: 1195 RP---------------------ESSLVFKDTLRTPPRERSGAGSSPETKEQN---SALP 1230
Query: 1000 RSA--DYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMY 1057
S+ + M+ ++ + A ++ L E + S E +E+ P S +
Sbjct: 1231 TSSQDEELMEVVEKSEEPAGQILSHLSSELK--EMSTSNFESSPEVEERPAVSLTLDQSQ 1288
Query: 1058 SE-TVELIRYAMRLKTHSGPNATPEDKQLA 1086
S+ ++E + + GP+ +PE K+L+
Sbjct: 1289 SQASLEAVEVPSMASSWGGPHFSPEHKELS 1318
Score = 46.2 bits (108), Expect = 2e-04
Identities = 158/766 (20%), Positives = 250/766 (32%), Gaps = 157/766 (20%)
Query: 271 DESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLS-------KFSIPKQGEE-----S 318
+ SP++K S +S R S P ++AK++LS PKQ + S
Sbjct: 744 NSSPEMKKS-----RISSRRSRSLSSPR-SKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS 797
Query: 319 RSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEP 378
RSG + + + PP + + K P++ S SS H K G
Sbjct: 798 RSGSSQP------KAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPR 851
Query: 379 ESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGS 438
+ + S E + + RT R + P ++S P +
Sbjct: 852 QGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGS--SPPRVKSSTPPRQSP 909
Query: 439 SSSSSSG-------SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE--PASSN 489
S SSS S S S SSS S S S ++ S+ E+ P S+
Sbjct: 910 SRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSH 969
Query: 490 KWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIK 549
KV P PP +SH + Y KV P K
Sbjct: 970 SGSSSPD-TKVKPETPP----RQSHSGSISPY-----------PKVKAQTPPGPSLSGSK 1013
Query: 550 STCKEEQ-RPRTANKAPGS----KGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPA 604
S C +E+ + PGS GVK +PP VS+ ++ +P
Sbjct: 1014 SPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQ-------LKGQSQTSPD 1066
Query: 605 RRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 664
RS P R + E P+ ++T P G S
Sbjct: 1067 HRSDTSSPEVRQSHS-----------ESPSLQSK-----------SQTSPKGGRSRSSSP 1104
Query: 665 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 724
+ R+ RG P K S S S +S+ YP TV ++
Sbjct: 1105 VTELASRSPIRQDRGEFSASPMLK--------SGMSPEQSRFQSDSSSYP-----TVDSN 1151
Query: 725 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKD 784
+ G RL+ A + +A +E T P + + SP
Sbjct: 1152 SLLGQS-RLE-----------------TAESKEKMALPPQEDA-TASPPRQKDKFSPFPV 1192
Query: 785 SDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKR 844
D S V D R P + G S+P TK+ SA P+ + D + + KS+
Sbjct: 1193 QDRPESSLVFKDTL---RTPPR--ERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEE 1247
Query: 845 ---KRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIP-------- 893
+ + +E+ S E + S TL + ++ +V +P
Sbjct: 1248 PAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGG 1307
Query: 894 ---INKNEKMLRSPI--------------SPLSDASKHKYTSEDLTSSSRPNGNSLFTSA 936
+++++ SP+ PL ++SE + P N L T
Sbjct: 1308 PHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDP 1367
Query: 937 SSSKKPK-------ADSQLQPHGGDLTKAAHNNSENIPLHKSRPQT 975
S K + + S+L P + + N S + P+ + P+T
Sbjct: 1368 SLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRT 1413
Score = 41.2 bits (95), Expect = 0.006
Identities = 146/715 (20%), Positives = 242/715 (33%), Gaps = 135/715 (18%)
Query: 243 PSLASKPSLVQQKPTAYVRPMDGQDQAPD-------ESPKLKSSSETSVHCTSYRGVPAS 295
P SK SLVQ P + + P S +LK S+TS S P
Sbjct: 1017 PQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEV 1076
Query: 296 KPEPARAKAKLSKFSIPKQGEESRSGE------TNSCVEEIIREMTWLPPLSAIQAPGKV 349
+ + + + SK +G SRS + S + + E + P L + +P
Sbjct: 1077 RQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSP--- 1133
Query: 350 EPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAA 409
E ++F DS + +N G + E+ ++ ++D S ++++
Sbjct: 1134 EQSRF---QSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPF 1190
Query: 410 QRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSE 469
++ +S++V + RT G+ SS + +S+ + S E S E
Sbjct: 1191 P---VQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEE 1247
Query: 470 SEGSKPPHFSSPEAEPASSN------------------------------------KW-- 491
G H SS E ++SN W
Sbjct: 1248 PAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGG 1307
Query: 492 --------QLDKWLNKVNPHKPPILIQNESH-GSESNQ-YYNPVKEDVQDCGKVPDVCQP 541
+L + N P+ +N G+E N + + VKED+ P
Sbjct: 1308 PHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDP 1367
Query: 542 SLREKEIKST-----CKEEQRPRTANKAPGSKGVKQKSPPAAVAV--------AVSAAAP 588
SL KE +ST E P KA G + S P AV + SA++P
Sbjct: 1368 SLDMKE-QSTRSSGHSSSELSPDAVEKA-GMSSNQSISSPVLDAVPRTPSRERSSSASSP 1425
Query: 589 P-----PAVPCAPAENAPAPARRSAGKKPTRRT-----------ERTSAGDGANCHRPEE 632
P P + + +P R P+R + RT + + C E
Sbjct: 1426 EMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPE 1485
Query: 633 PAAADALGTSVVVPPEPTKTRPCG---NNRA-SHRKELRSSVTCEKRRTRGLSRIVPKSK 688
P A + P P P NN+ + ++E S + ++T + + +S+
Sbjct: 1486 PKA-------LPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSR 1538
Query: 689 EFIETESSSSSSSSDSDLESEQEEYPLSKAQT---------VAASASSGNDQRLKEAAAN 739
E S+S + SE + P SKA+T +S + RL +
Sbjct: 1539 SGSSQELDVKPSASPQE-RSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR 1597
Query: 740 GGSGPRA---PVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKID 796
GS P P + A++ SD + E + +P R+ S K
Sbjct: 1598 SGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALP-RRSRSGSSSKGRGPSPE-----G 1651
Query: 797 LTLLSRIPEHLPQ----EPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRK 847
+ PEH P+ G S+P K PP S + + K++ R+
Sbjct: 1652 SSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRR 1706
Score = 40.4 bits (93), Expect = 0.011
Identities = 147/716 (20%), Positives = 245/716 (34%), Gaps = 116/716 (16%)
Query: 355 PFPNKDSQLV----SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ 410
P P K LV SS PK+ + + S +S + K SS ++++ ++
Sbjct: 165 PEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESES 224
Query: 411 RTAL--------RALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGS--- 459
+ + S ++ T P S+ + S+S+ S+SSS S S S S
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAA 284
Query: 460 ---------DSETESSSSESEGSKP---------PHFSSPE--AEPASSNKWQLDKWLNK 499
S + +S EG P SSPE + SS DK +
Sbjct: 285 KTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKE 344
Query: 500 VNPHKPPILIQNESHGSESNQYYNPVKE----DVQDCGKVPDVCQPSLREKEIKSTCKEE 555
+ +P + S G E + E Q P + Q + S ++
Sbjct: 345 KSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTP-LSQEPVNPPSEASPTRDR 403
Query: 556 QRPRTANKAPGSKGVKQKSPPAAVAVAVS--AAAPPPAVPCAPA-------ENAPAPARR 606
P++ K P S + SPP+ VS A++ P + APA ++P R
Sbjct: 404 SPPKSPEKLPQSSS-SESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNR 462
Query: 607 SAGKKPTRRTERTSAGDGANCHRPEEPAAA----------DALGTSVVVPPEPTKTRPC- 655
S G+ +R + S R PA A G S P+ ++R
Sbjct: 463 SHGR--AKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQ 520
Query: 656 --GNNRASHRKELRSS------VTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE 707
G +R+ R+ S + RG SR + + + ++ S S +
Sbjct: 521 RWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPAR 580
Query: 708 SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQF 767
+ + + + R + A G S R P +RT S + +
Sbjct: 581 RGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR-RSRTRSPVRR------ 633
Query: 768 YTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPP 827
R+ SP + S RS SR P + PA + S
Sbjct: 634 -------RSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRS--RTPARRSGRS--- 681
Query: 828 SHTSDTPAEKALPKSKRKRKCDNED--------DYREIKKSQGEKDSSS--RLATSTSNT 877
S TPA + +S+ R+ + + + +G SSS + + TS
Sbjct: 682 --RSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR 739
Query: 878 LSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS----RPNGNSLF 933
S ++ + + I + + RS SP S A L+ SS + +
Sbjct: 740 RSRSNSSPEMKKSRI----SSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR 795
Query: 934 TSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHRDCK 989
S S S +PKA S+ P + + ++S P KS+ ++ S+ H K
Sbjct: 796 RSRSGSSQPKAKSRTPP------RRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK 845
Score = 40.0 bits (92), Expect = 0.014
Identities = 74/360 (20%), Positives = 116/360 (32%), Gaps = 54/360 (15%)
Query: 402 EENEQQAAQRTALRALSDSAV-------------VQQPNCRTSVPSSKGSSSSSSSGSSS 448
E NE++ + A +SDS V +QP P S SSSS +
Sbjct: 126 ELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTP 185
Query: 449 SSSDSESSSGSDSETESSSSESE----GSKPPHFSSPEAE------PASSNKWQLDKWLN 498
+ +ESSS E K H S E++ P +K +
Sbjct: 186 KQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKR 245
Query: 499 KVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIK--STCKEEQ 556
K + P +H S S D D + R K +T +
Sbjct: 246 KRSRSTTPAPKSRRAHRSTS-----------ADSASSSDTSRSRSRSAAAKTHTTALAGR 294
Query: 557 RPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRT 616
P A+ G P S+ P +P E+ + + +P+
Sbjct: 295 SPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSP 354
Query: 617 ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRR 676
ER+S G PE PA L P+P T P + E +
Sbjct: 355 ERSSTG-------PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPT------- 400
Query: 677 TRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEA 736
R PKS E + +SSSS SS S ++ + S ++ + + G+ + + +
Sbjct: 401 ---RDRSPPKSPEKL-PQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSS 456
>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
sapiens]
Length = 1082
Score = 57.4 bits (137), Expect = 8e-08
Identities = 50/151 (33%), Positives = 65/151 (43%), Gaps = 9/151 (5%)
Query: 365 SSGHNNP-KKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVV 423
S G + P + D++PES S +S E SS E +NE Q R
Sbjct: 681 SEGESGPTESADSDPESESESDSKSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSE 739
Query: 424 QQPNCRTS--VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSP 481
+ +T VP KG +SSS GS SSSS SES S+SE E S K P S
Sbjct: 740 EDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTP--PSS 797
Query: 482 EAEPASSNKWQLDK---WLNKVNPHKPPILI 509
++ PA+ LD V P PP ++
Sbjct: 798 KSAPATKEISLLDLEDFTPPSVQPVSPPAIV 828
Score = 38.1 bits (87), Expect = 0.053
Identities = 45/170 (26%), Positives = 66/170 (38%), Gaps = 17/170 (10%)
Query: 424 QQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEA 483
++P S S + S+ S S S SDS+SSS S S SS S++E +
Sbjct: 674 EKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGS 733
Query: 484 EPASSNKWQLDKWLNKVNPHKPPILIQNE-----SHGSESNQYYNPVKEDVQDCG---KV 535
E S + K KV K +E S SES +E ++ K
Sbjct: 734 ESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKT 793
Query: 536 PDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSA 585
P + + KEI E+ P V+ SPPA V+ +++A
Sbjct: 794 PPSSKSAPATKEISLLDLEDFTP---------PSVQPVSPPAIVSTSLAA 834
Score = 32.7 bits (73), Expect = 2.2
Identities = 46/213 (21%), Positives = 76/213 (35%), Gaps = 12/213 (5%)
Query: 630 PEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIV---PK 686
P+ P A V PE TK C N RKE + G + P+
Sbjct: 642 PDWPEEAPDPSVRNVEVPEWTK---CSNREK--RKEKEKPFYSDSEGESGPTESADSDPE 696
Query: 687 SKEFIETESSSSS----SSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGS 742
S+ +++SSS S SSS+SD E + E+ + S G + K+ G
Sbjct: 697 SESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGE 756
Query: 743 GPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSR 802
+ GS ++ ++S+ E + L P + P S +DL +
Sbjct: 757 ASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTP 816
Query: 803 IPEHLPQEPGVLSAPATKDSESAPPSHTSDTPA 835
P ++S D E + ++ P+
Sbjct: 817 PSVQPVSPPAIVSTSLAADLEGLTLTDSTLVPS 849
>gi|6857826 RNA-binding protein S1, serine-rich domain [Homo
sapiens]
Length = 305
Score = 57.4 bits (137), Expect = 8e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP- 590
+ + P R S E + P A KA Q A AV A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPP 246
Query: 591 ---------AVPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|18379334 RNA-binding protein S1, serine-rich domain [Homo
sapiens]
Length = 305
Score = 57.4 bits (137), Expect = 8e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 359 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 417
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 418 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 476
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 477 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 534
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 535 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP- 590
+ + P R S E + P A KA Q A AV A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPP 246
Query: 591 ---------AVPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 629
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 647 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 706
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 707 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 747
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/259 (23%), Positives = 98/259 (37%), Gaps = 24/259 (9%)
Query: 294 ASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTK 353
+ +P P + + F P+ + VE+ R+ P + + G+V
Sbjct: 505 SQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPP 564
Query: 354 FP-----FPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLED-DLKLSSDEEENEQQ 407
P F N +S+ V P AEP+ P TS + +L D L ++N Q
Sbjct: 565 VPSRSESFSNGNSESVHPALQRP----AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQ- 619
Query: 408 AAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSS 467
A QR + ++ + ++ P S SS SS+SGS S S + SS
Sbjct: 620 AGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSS 679
Query: 468 SESEGSKPPHFSSPEAEPASSNK-------------WQLDKWLNKVNPHKPPILIQNESH 514
S+SEGS + +P + L K L V +PP + + S
Sbjct: 680 SKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSS 739
Query: 515 GSESNQYYNPVKEDVQDCG 533
SE + + +DV+ G
Sbjct: 740 SSEESGTTDEEDDDVEQEG 758
>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
Length = 2089
Score = 55.5 bits (132), Expect = 3e-07
Identities = 108/519 (20%), Positives = 189/519 (36%), Gaps = 79/519 (15%)
Query: 224 PPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDES---------P 274
PP S H PP L S P L KPT DG +AP+ P
Sbjct: 1048 PPQKPLNSQSQKHLA---PPPLLS-PLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHP 1103
Query: 275 KLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCV---EEII 331
K K + S T + A+ PEP + + + + +RS S V E ++
Sbjct: 1104 KPKIRTRKSSRMTPFPATSAA-PEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVV 1162
Query: 332 REMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSML 391
L P ++ P EPT SQ+ +K + ++P+ T + L
Sbjct: 1163 PTAPELQPSTSTDQPVTSEPT--------SQVTRG-----RKSRSSVKTPE--TVVPTAL 1207
Query: 392 EDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 451
E S+D + +Q T R S +P VP++ S+S+ +S
Sbjct: 1208 ELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEP----VVPTAPELQPSTSTDQPVTSE 1263
Query: 452 DSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQN 511
+ ++ + S + +P ++PE P++S P+ +
Sbjct: 1264 PTYQATRG----RKNRSSVKTPEPVVPTAPELRPSTSTD--------------RPVTPKP 1305
Query: 512 ESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVK 571
S + S + VK P+ P+ E +I ++ + P+ P S+ +
Sbjct: 1306 TSRTTRSRTNMSSVK--------TPETVVPTAPELQISTSTDQPVTPK-----PTSRTTR 1352
Query: 572 QKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPE 631
++ ++V S P +P P+ + P + TR + S+G P
Sbjct: 1353 SRTNMSSVKNPESTVPIAPELP--PSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPT 1410
Query: 632 EPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSK--E 689
P + T V PEPT ++A+ + RSSV + + P + +
Sbjct: 1411 APKLEPSTSTDQPVTPEPT-------SQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQ 1463
Query: 690 FIETESSSSSSSSDSDLES-EQEEYPLSKAQTVAASASS 727
+ E +S ++ +D S + E + A + ASAS+
Sbjct: 1464 PVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASAST 1502
Score = 41.2 bits (95), Expect = 0.006
Identities = 96/481 (19%), Positives = 166/481 (34%), Gaps = 88/481 (18%)
Query: 223 RPPAMAAKHSSSGHCVQNFPPSLASKPSL---------VQQKPTAYV---RPMDGQDQAP 270
+P + A + ++ V+ P + + P L V +PT+ V R + P
Sbjct: 1140 KPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTP 1199
Query: 271 DE----SPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSC 326
+ + +L+ S+ T TS A++ R+ K + +P E S T+
Sbjct: 1200 ETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQP 1259
Query: 327 V--EEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNG 384
V E + S+++ P V PT + P P +P
Sbjct: 1260 VTSEPTYQATRGRKNRSSVKTPEPVVPT-------------APELRPSTSTDRPVTP-KP 1305
Query: 385 TSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSS 444
TS T+ ++ S E A + +D V +P RT+ + SS +
Sbjct: 1306 TSRTTRSRTNMS-SVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPE 1364
Query: 445 GS---------SSSSSDSESSSGSDSETESSSSESEGSKPPHF--SSPEAEPASSNKWQL 493
+ S+S+ + + T + S G P ++P+ EP++S
Sbjct: 1365 STVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTD--- 1421
Query: 494 DKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCK 553
P+ + S + + VK P+ P+ E + ++
Sbjct: 1422 -----------QPVTPEPTSQATRGRTNRSSVK--------TPETVVPTAPELQPSTSTD 1462
Query: 554 EEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPT 613
+ P ++A ++G +S S P VP AP A A + +PT
Sbjct: 1463 QPVTPEPTSQA--TRGRTDRS---------SVKTPETVVPTAPELQASASTDQPVTSEPT 1511
Query: 614 RRTER----TSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSS 669
RT R S+ P P + T V PEPT +RA+ + RSS
Sbjct: 1512 SRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPT-------SRATRGRTNRSS 1564
Query: 670 V 670
V
Sbjct: 1565 V 1565
Score = 40.4 bits (93), Expect = 0.011
Identities = 130/653 (19%), Positives = 225/653 (34%), Gaps = 106/653 (16%)
Query: 111 RSNQSHLVGVPKPGVPQTPV----NKIDEHFVAD-----SRAQNQPSSICSTTTSTPAAV 161
R+N+S V P+P VP P D+ ++ +R + SS+ + T P A+
Sbjct: 1149 RTNRSS-VKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTAL 1207
Query: 162 PVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQ 221
+Q S + P S + + S++T + V P + + + + ++
Sbjct: 1208 ELQPST--STDRPVTSEPTSQATRGRKNRSSVKT--PEPVVPTAPELQPSTSTDQPVTSE 1263
Query: 222 ERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSS- 280
P A + + V+ P + + P L + T+ RP+ + + + SS
Sbjct: 1264 --PTYQATRGRKNRSSVKTPEPVVPTAPEL--RPSTSTDRPVTPKPTSRTTRSRTNMSSV 1319
Query: 281 ---ETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCV---EEIIREM 334
ET V + S +P K +RS S V E +
Sbjct: 1320 KTPETVVPTAPELQISTSTDQPVTPKPT---------SRTTRSRTNMSSVKNPESTVPIA 1370
Query: 335 TWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDD 394
LPP ++ + P EPT + G N G ++P+ LE
Sbjct: 1371 PELPPSTSTEQPVTPEPTS---------RATRGRKNRSSG----KTPETLVPTAPKLEPS 1417
Query: 395 LKLSSDEEENEQQAAQRTALRALSDS----------AVVQQPNCRTSVPSSKGSSSSSSS 444
S+D+ + +Q T R S A QP+ T P + +S ++
Sbjct: 1418 T--STDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATR 1475
Query: 445 GSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHK 504
G + SS + + E +S S + P S P + K N+ +
Sbjct: 1476 GRTDRSSVKTPETVVPTAPELQASAS--TDQPVTSEPTSRTTRGRK-------NRSSVKT 1526
Query: 505 PPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKA 564
P ++ S PV + + S++ E E +P T+
Sbjct: 1527 PETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQ 1586
Query: 565 -----PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRR-TER 618
P S+ + ++ ++V P P VP AP + + K T R T R
Sbjct: 1587 LVTPEPTSRATRCRTNRSSVKT------PEPVVPTAPEPHPTTSTDQPVTPKLTSRATRR 1640
Query: 619 TSAGDGANCHRPEEPAAADALGTSVVVPPEPT--KTRPCGNNRASHRKELRSSVTCEKRR 676
+ +P EPAA+D + P PT P + K LRSS
Sbjct: 1641 KTNRSSVKTPKPVEPAASD------LEPFTPTDQSVTPEAIAQGGQSKTLRSSTV----- 1689
Query: 677 TRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGN 729
+ VP + EF S ++D + E P+++ + ++GN
Sbjct: 1690 ---RAMPVPTTPEF------QSPVTTDQPISPE----PITQPSCIKRQRAAGN 1729
>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
sapiens]
Length = 2462
Score = 55.5 bits (132), Expect = 3e-07
Identities = 116/527 (22%), Positives = 185/527 (35%), Gaps = 86/527 (16%)
Query: 355 PFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTAL 414
P P + SQ K+ + E E P+ +L++ +S E+ +E++A
Sbjct: 511 PMP-RSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKG- 568
Query: 415 RALSDSAVVQQPNCRTSVPSSKGSSSS---SSSGSSSSSSDSESSSGSDSETE------- 464
R ++S ++ S+ + S + S +S +ESS ++ E E
Sbjct: 569 RKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLL 628
Query: 465 ------SSSSESEGSKPP------HFSSPEA----EPASSNKWQLDKWLNKVNPHKPPIL 508
S+ + GSK +F+ + E +K +++K N K
Sbjct: 629 EHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKK---- 684
Query: 509 IQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKE--IKSTCKEEQRPRTANKAPG 566
+ + SE + V+++ + V + + E E + ++ E P +A
Sbjct: 685 -KAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK 743
Query: 567 SKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGAN 626
G PPA + A PPP P P E+ PAP +PT +E T A
Sbjct: 744 DTGQNGPKPPATLG----ADGPPPGPPTPPPEDIPAPT------EPTPASEATGA----- 788
Query: 627 CHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 686
P P A PP P+ P KE + T P
Sbjct: 789 ---PTPPPA----------PPSPSAPPPV------VPKEEKEEETAAAPPVEEGEEQKPP 829
Query: 687 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSG--- 743
+ E + ++ + S+ E EE P AA A++ + LK GGSG
Sbjct: 830 AAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATA--EGALKAEKKEGGSGRAT 887
Query: 744 ----PRAPVGSINARTTS-DIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLT 798
AP S ++ T S D E E + R LL+P D S +DL
Sbjct: 888 TAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLK 947
Query: 799 LLSRIPEHLP-------QEPGVLSAPATKDSESAPPSHTSDTPAEKA 838
L + +P EP A TK + APP + P A
Sbjct: 948 QLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDA 994
Score = 38.1 bits (87), Expect = 0.053
Identities = 68/312 (21%), Positives = 105/312 (33%), Gaps = 68/312 (21%)
Query: 362 QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSA 421
Q SS H++ P P + T T+ + + D E + + +++ L S +
Sbjct: 1757 QPFSSRHSS---SPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILT--STTT 1811
Query: 422 VVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSP 481
V P R S GSS SS G SSS + + S + + P +
Sbjct: 1812 VEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA---------SHSHAHQHSPISPRTQDAL 1862
Query: 482 EAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVK-----EDVQDC---- 532
+ P+ + + + V P P +L S +PV+ C
Sbjct: 1863 QQRPSVLHNTGMKGIITAVEPSTPTVL--------RSTSTSSPVRPAATFPPATHCPLGG 1914
Query: 533 ---GKVPDVCQPSLREKEIKSTCKEEQRPRTAN------KAPGSKGVKQKSPPA------ 577
G P + +P L KE + E RPR K P G++ S P+
Sbjct: 1915 TLDGVYPTLMEPVLLPKEAPRVARPE-RPRADTGHAFLAKPPARSGLEPASSPSKGSEPR 1973
Query: 578 ----------------AVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKP--TRRTERT 619
A +A A+P P P A A + P R KP + E
Sbjct: 1974 PLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASD---PHREKTQSKPFSIQELELR 2030
Query: 620 SAGDGANCHRPE 631
S G + + PE
Sbjct: 2031 SLGYHGSSYSPE 2042
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.122 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,174,929
Number of Sequences: 37866
Number of extensions: 2815567
Number of successful extensions: 33501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 306
Number of HSP's successfully gapped in prelim test: 975
Number of HSP's that attempted gapping in prelim test: 20210
Number of HSP's gapped (non-prelim): 8602
length of query: 1251
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1137
effective length of database: 13,930,794
effective search space: 15839312778
effective search space used: 15839312778
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.