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Search of human proteins with 68348714
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens]
(1226 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens] 2461 0.0
gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens] 2443 0.0
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 650 0.0
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 543 e-154
gi|87162461 fragile X mental retardation 2 [Homo sapiens] 462 e-130
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 77 1e-13
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 70 1e-11
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 70 1e-11
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 69 3e-11
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 67 1e-10
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor... 65 4e-10
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 65 4e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 1e-09
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 63 2e-09
gi|55741677 SET domain containing 1A [Homo sapiens] 61 6e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 60 1e-08
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 60 1e-08
gi|169166609 PREDICTED: similar to ribonucleic acid binding prot... 59 2e-08
gi|113415994 PREDICTED: similar to ribonucleic acid binding prot... 59 2e-08
gi|113415504 PREDICTED: similar to ribonucleic acid binding prot... 59 3e-08
gi|169166499 PREDICTED: similar to ribonucleic acid binding prot... 59 3e-08
gi|113415498 PREDICTED: similar to ribonucleic acid binding prot... 59 3e-08
gi|88973230 PREDICTED: similar to ribonucleic acid binding prote... 59 3e-08
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 59 3e-08
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H... 57 8e-08
gi|6857826 RNA-binding protein S1, serine-rich domain [Homo sapi... 57 8e-08
gi|18379334 RNA-binding protein S1, serine-rich domain [Homo sap... 57 8e-08
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 56 2e-07
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens] 55 3e-07
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap... 55 3e-07
>gi|68348714 AF4/FMR2 family, member 3 isoform 1 [Homo sapiens]
Length = 1226
Score = 2461 bits (6377), Expect = 0.0
Identities = 1226/1226 (100%), Positives = 1226/1226 (100%)
Query: 1 MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTN 60
MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTN
Sbjct: 1 MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTN 60
Query: 61 KGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQN 120
KGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQN
Sbjct: 61 KGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQN 120
Query: 121 QPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQ 180
QPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQ
Sbjct: 121 QPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQ 180
Query: 181 PRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDG 240
PRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDG
Sbjct: 181 PRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDG 240
Query: 241 QDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNS 300
QDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNS
Sbjct: 241 QDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNS 300
Query: 301 CVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT 360
CVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT
Sbjct: 301 CVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT 360
Query: 361 SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG 420
SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG
Sbjct: 361 SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG 420
Query: 421 SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKP 480
SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKP
Sbjct: 421 SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKP 480
Query: 481 PILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAP 540
PILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAP
Sbjct: 481 PILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAP 540
Query: 541 GSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGA 600
GSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGA
Sbjct: 541 GSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGA 600
Query: 601 NCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVP 660
NCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVP
Sbjct: 601 NCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVP 660
Query: 661 KSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPR 720
KSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPR
Sbjct: 661 KSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPR 720
Query: 721 APVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE 780
APVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE
Sbjct: 721 APVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE 780
Query: 781 HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD 840
HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD
Sbjct: 781 HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD 840
Query: 841 SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS 900
SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS
Sbjct: 841 SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS 900
Query: 901 RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH 960
RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH
Sbjct: 901 RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH 960
Query: 961 RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ 1020
RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ
Sbjct: 961 RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ 1020
Query: 1021 GPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKR 1080
GPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKR
Sbjct: 1021 GPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKR 1080
Query: 1081 DHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNAS 1140
DHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNAS
Sbjct: 1081 DHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNAS 1140
Query: 1141 ALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVT 1200
ALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVT
Sbjct: 1141 ALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVT 1200
Query: 1201 LHSSMEHLVQYSQQGLHWLRNSAHLS 1226
LHSSMEHLVQYSQQGLHWLRNSAHLS
Sbjct: 1201 LHSSMEHLVQYSQQGLHWLRNSAHLS 1226
>gi|68348716 AF4/FMR2 family, member 3 isoform 2 [Homo sapiens]
Length = 1251
Score = 2443 bits (6331), Expect = 0.0
Identities = 1225/1251 (97%), Positives = 1225/1251 (97%), Gaps = 25/1251 (1%)
Query: 1 MDSFDLALLQEWDLESL-------------------------CVYEPDRNALRRKERERR 35
MDSFDLALLQEWDLESL VYEPDRNALRRKERERR
Sbjct: 1 MDSFDLALLQEWDLESLWGEDILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERR 60
Query: 36 NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV 95
NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV
Sbjct: 61 NQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGV 120
Query: 96 PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP 155
PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP
Sbjct: 121 PKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPP 180
Query: 156 SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN 215
SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN
Sbjct: 181 SDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQN 240
Query: 216 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA 275
FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA
Sbjct: 241 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPA 300
Query: 276 RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD 335
RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD
Sbjct: 301 RAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKD 360
Query: 336 SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS 395
SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS
Sbjct: 361 SQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDS 420
Query: 396 AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS 455
AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS
Sbjct: 421 AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSS 480
Query: 456 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ 515
PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ
Sbjct: 481 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQ 540
Query: 516 PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA 575
PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA
Sbjct: 541 PSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENA 600
Query: 576 PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA 635
PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA
Sbjct: 601 PAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRA 660
Query: 636 SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT 695
SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT
Sbjct: 661 SHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT 720
Query: 696 VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS 755
VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS
Sbjct: 721 VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLS 780
Query: 756 PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP 815
PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP
Sbjct: 781 PLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALP 840
Query: 816 KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM 875
KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM
Sbjct: 841 KSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKM 900
Query: 876 LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH 935
LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH
Sbjct: 901 LRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAH 960
Query: 936 NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV 995
NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV
Sbjct: 961 NNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMV 1020
Query: 996 EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP 1055
EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP
Sbjct: 1021 EKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATP 1080
Query: 1056 EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG 1115
EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG
Sbjct: 1081 EDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTG 1140
Query: 1116 TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW 1175
TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW
Sbjct: 1141 TPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYW 1200
Query: 1176 EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS 1226
EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS
Sbjct: 1201 EMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS 1251
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 650 bits (1677), Expect = 0.0
Identities = 463/1271 (36%), Positives = 650/1271 (51%), Gaps = 182/1271 (14%)
Query: 23 DRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYK-TNKGDELSNRIQNTLGNYDEMKD 81
DRN LR KERERRNQE QQ + F S LF+EPYK T+K D+LS+RIQ+ LGNYDEMKD
Sbjct: 5 DRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKD 64
Query: 82 FLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQS 141
F+ DRS LV +PKP VP + K + +F + SS T PA Q
Sbjct: 65 FIGDRSIPK-LVAIPKPTVPPSADEKSNPNFFEQRHGGSHQSS--KWTPVGPAPSTSQSQ 121
Query: 142 KR------------------------------------GTMGWQKAGHPPSDGQQRATQQ 165
KR G+ +K H + R++
Sbjct: 122 KRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSSP 181
Query: 166 GSLRTLLG-----------DGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQ 214
G + + D ++ R+K + + + R P + +HS+ Q
Sbjct: 182 GKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHST-----Q 236
Query: 215 NFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEP 274
+FPPSL SK + + QKPTAYVRPMDGQ+ PKL S +S G ++ +P
Sbjct: 237 SFPPSLMSKSNSMLQKPTAYVRPMDGQESM---EPKLSSEHYSS----QSHGNSMTELKP 289
Query: 275 ARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMT--WLPPLSAIQAPGKVEPTKFPFP 332
+ +KA L+K IP Q ++ + SCV+EI++EMT W PPL+AI P K EP+KFPFP
Sbjct: 290 S-SKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFP 348
Query: 333 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRAL 392
K+SQ + G K+ + P NG + SML+DDLKLSS E+ + +Q +T R+
Sbjct: 349 TKESQQSNFGTGEQKRYN--PSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRST 406
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPH 452
S N S +S+G+ +S SSS S SESSSGSDSE+ESSSS+SE ++P
Sbjct: 407 PGS------NSEPSHHNSEGADNSRDD--SSSHSGSESSSGSDSESESSSSDSEANEPSQ 458
Query: 453 FSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGK-VP 511
+SPE EP +NKWQLD WLNKVNPHK +S+ S Y +E Q G
Sbjct: 459 SASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGRE--QGTGNSYT 516
Query: 512 DVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAP 571
D P KE S +T K S +QKSP
Sbjct: 517 DTSGP----KETSSATPGRDS-KTIQKGSESGRGRQKSP--------------------- 550
Query: 572 AENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCG 631
A++ RR+ GKK ++ E+ +A + + E D + +P K G
Sbjct: 551 AQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASS---MPSSRHKAATKG 607
Query: 632 NNRASHRKELRSSV--TCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL--ESEQEE 687
+ + + +KE +SS T EK++ + S+ KS+E IET++SSS S L S+ +
Sbjct: 608 SRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPK 667
Query: 688 YPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVP 747
YP S V S+ D ++ + P
Sbjct: 668 YPESNRTPVKPSSVEEEDSFFRQRMFS--------------------------------P 695
Query: 748 FGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSD 807
ELLSPL + D+ L VKIDL LL+RIP +P + P + ++ P HT +
Sbjct: 696 MEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPG----KPYKETEPPKGEKKNVPEKHTRE 751
Query: 808 TP---AEKALPKSKRKRKCDNEDDYR---------EIKKSQGEKDSSSRLATSTSNTLSA 855
+EK K KRK K NEDD R E K S G K SS+R ++ S
Sbjct: 752 AQKQASEKVSNKGKRKHK--NEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQSAAKEK 809
Query: 856 NHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSK 915
+ V K E R S + K S TS S N S+S+SK
Sbjct: 810 DLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKN------SSSTSK 863
Query: 916 KPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPR 975
+ K + + ++ + A ++S N P P +P + + +R KLVFDD
Sbjct: 864 QKKTEGKTSSSSKEVKEKAPSSSSNCP---------PSAPTLDSSKP-RRTKLVFDDRNY 913
Query: 976 SADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSET 1035
SAD+++QEAK++KH ADA+ ++F KA+ Y +A +SFIECGNA+E+ ESKSP+ MYSET
Sbjct: 914 SADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSET 973
Query: 1036 VELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFK 1095
V+LI+Y M+LK + P+AT DK+L LC RC +LLY R+F+LK+++A+KYSK L ++ K
Sbjct: 974 VDLIKYTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLK 1033
Query: 1096 NSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIH 1155
NS +QAPSP G K+ G PSP+SP SP +S S+ASA S V+IPQ+IH
Sbjct: 1034 NSYNNSQAPSP-GLGSKAVGMPSPVSPKLSPGNSGNYSSGASSASASGSS--VTIPQKIH 1090
Query: 1156 QMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSS-MEHLVQYSQQ 1214
QMAA++V +T++ L++ + W+ A+ L+KE +EFF +LD +MGP+ ++S M LV+Y++Q
Sbjct: 1091 QMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVRYTRQ 1150
Query: 1215 GLHWLRNSAHL 1225
GLHWLR A L
Sbjct: 1151 GLHWLRQDAKL 1161
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 543 bits (1399), Expect = e-154
Identities = 435/1291 (33%), Positives = 624/1291 (48%), Gaps = 182/1291 (14%)
Query: 19 VYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDE 78
+Y DRN LR +E+ERRNQE Q+ F LF EPYKT KGDELS+RIQN LGNY+E
Sbjct: 7 LYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEE 66
Query: 79 MKDFLTDRSNQSHL------VGVPK-PGVP-----------QTPVNKIDEHF-------- 112
+K+FL+ +S+ L +G PK P +P T V+ H
Sbjct: 67 VKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSV 126
Query: 113 --------VADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGW----QKAGHPPSDGQQ 160
+A R + P S+ + + P + + Q + G G+ K G +DG
Sbjct: 127 GNISHNPKMAQPRTEPMP-SLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDH 185
Query: 161 RATQQGSL-RTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSS----GHC--- 212
A+ S L + P + + QT R + H SS G+C
Sbjct: 186 CASVTDSAPERELSPLISLPSP-VPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAK 244
Query: 213 --------------------------VQNF-PPSLASKPSLVQQKPTAYVRPMDGQDQAP 245
Q F PPSL SK +QQKPTAYVRPMDGQDQAP
Sbjct: 245 SPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAP 304
Query: 246 DESPKLKSSSETSVHCTSYRGVPASKPE-PARAKAKLSKFSIPKQGEESRSGETNSCVEE 304
ESP+LK E YR K + AKAKL+K +P Q E CVEE
Sbjct: 305 SESPELKPLPE------DYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEE 358
Query: 305 IIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSN 362
I++EMT W PPL+AI P EP+KFPFP KDSQ VSS N K+ D ++ N
Sbjct: 359 ILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQG 418
Query: 363 T-SMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGS 421
T SMLEDDL+LS E+ + +Q ++ S SA P+ S+P +S+ SSS
Sbjct: 419 TSSMLEDDLQLSDSEDSDSEQTPEKPP----SSSA---PPSAPQSLPEPV-ASAHSSSAE 470
Query: 422 SSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVN-PHKP 480
S S+SDS+SS SDSE+ESSSS+SE ++P +PE EP ++NKWQLD WL KV+ P P
Sbjct: 471 SESTSDSDSS--SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAP 528
Query: 481 PILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAP 540
P E + P + + G E ++ P++++KAP
Sbjct: 529 P----------EGPRSTEPPRRHPESKGSSDSATSQEHSE-------SKDPPPKSSSKAP 571
Query: 541 GSKGVKQKSPPAAVAVAVSAAAPPP---AVPCAPAENAPAPARRSAGKKPTRRTERTSAG 597
++PP AP P + +PA+ P P R++ G K ++ + SA
Sbjct: 572 -------RAPP---------EAPHPGKRSCQKSPAQQEP-PQRQTVGTKQPKKPVKASAR 614
Query: 598 DGANCH-RPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLS 656
G+ + E G+ + K + G RA+ E + +V + + S
Sbjct: 615 AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKS 674
Query: 657 RIVPKSKEFIETESSSSSSSSDSDLESEQEEY----PLSKAQTVAASASSGNDQRLKEAA 712
+ SK + S + ++E E+ PL+++Q S S ++A
Sbjct: 675 SLPAPSK------ALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAV 728
Query: 713 ANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDL 772
+ +E + +P +LLSPL+D+ +SL VKI L
Sbjct: 729 ---------------------VVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITL 767
Query: 773 TLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREI 832
LLSRIP+ P G A A H+S+ + + K +KRK + E D +
Sbjct: 768 DLLSRIPQ--PPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDC-DN 824
Query: 833 KKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYT 892
KK + EK+ S+ S++ S++H + + P +++ K P P+S +S+ K
Sbjct: 825 KKIRLEKEIKSQ-----SSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQ-KPA 878
Query: 893 SEDLTSSSRPN---GNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQ 949
L S R G SASS+K DS + K + ++SE+
Sbjct: 879 KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTAN 938
Query: 950 TKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAAL 1009
P NG+ + ++ FD + AD M+EAK+MK KA+ M ++ GKA Y EA L
Sbjct: 939 PFPVPSLPNGNSKPGKPQVKFD--KQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVL 996
Query: 1010 SFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLA 1069
SFIECG A E SKS Y++YSETV+LI++ M LK+ S A ++K A LC RC +
Sbjct: 997 SFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQS 1056
Query: 1070 LLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASS 1129
+L MFR K+D A+KYS+ L +F++SSK AQAPSP A STGTPSP+SP PSPASS
Sbjct: 1057 ILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIA---STGTPSPLSPMPSPASS 1113
Query: 1130 VGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFF 1189
VGSQ S + + + +S P I M +++V+IT+ +L ++D WE A+ L ++N+EFF
Sbjct: 1114 VGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFF 1173
Query: 1190 NDLDLLMGPVTLHSSMEHLVQYSQQGLHWLR 1220
L + + L+SS+ LV Y++QG L+
Sbjct: 1174 ARLSTNVCTLALNSSLVDLVHYTRQGFQQLQ 1204
>gi|87162461 fragile X mental retardation 2 [Homo sapiens]
Length = 1311
Score = 462 bits (1190), Expect = e-130
Identities = 334/995 (33%), Positives = 486/995 (48%), Gaps = 117/995 (11%)
Query: 1 MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYK-- 58
MD FD ++WDLE C YE DR+AL+++E ERRNQE QQ+D F+S + LF EPYK
Sbjct: 1 MDLFDF--FRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVA 58
Query: 59 --TNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADS 116
TNKGD L+NR+QNTLGNYDEMK+ LT+ SNQ+HLVG+PK VPQ P NK + F +
Sbjct: 59 EYTNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQ 118
Query: 117 RAQNQPSSICSTTTSTPAAVP---------VQQSKRGTMGWQKAGHPPSD--GQQRATQQ 165
+ + P +T S P P + +++ W + H PS Q + Q
Sbjct: 119 KNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQP 178
Query: 166 GSLRTLLGDG--------------------VGRQQPRAKQVCNV---------------- 189
++TL D V P AK+ N
Sbjct: 179 NKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNS 238
Query: 190 ----EVGLQTQERP-PAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQA 244
E +Q P A + SSG VQNFPP L K S+ QQKPTAYVRPMDGQDQA
Sbjct: 239 PEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQA 298
Query: 245 PDESPKLKSSSE--TSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCV 302
PD SP LK S E S S+ + KP A +K KL KF+I + E S + SCV
Sbjct: 299 PDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDP-SCV 357
Query: 303 EEIIREMT--WLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT 360
EEI+REMT W PL+++ G E + F P ++SQ ++ G K D +
Sbjct: 358 EEILREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSV 417
Query: 361 SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTS-----VPSSKGSSS 415
S SMLEDDLKLSSDE++ E T A V++ R + + + + +
Sbjct: 418 SFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPA 477
Query: 416 SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKV 475
+SG S SSS+SESSS SDS+TESS+++SE ++ P ++PE EP S+NKWQLDKWLNKV
Sbjct: 478 VQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKV 537
Query: 476 NPHKPPILIQNESHGSESNQYYNPVKEDVQ-------DCGKVPDVCQPSLREKEIKSTCK 528
+ E+ P+ + ++ + +VP +P +E+ + S +
Sbjct: 538 TSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVP--AEP--KERPLLSLIR 593
Query: 529 EEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPT 588
E+ RPR K P +K +K K + V ++R+ GKK
Sbjct: 594 EKARPRPTQKIPETKALKHKLSTTSETV----------------------SQRTIGKKQP 631
Query: 589 RRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTC- 647
++ E+ ++ D +P ++ SV + P ++ + RKE R ++
Sbjct: 632 KKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLA 691
Query: 648 -EKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQ 706
EK++ RG +IVPKS+EFIET+SS+S S++D + + + P S GN
Sbjct: 692 PEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLP-------PCIISGGNTA 744
Query: 707 RLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSL 766
+ KE G+ ++ + ++++ EE ++ +P + E+LSPL+D + +++L
Sbjct: 745 KSKEIC---GASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNL 801
Query: 767 WVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNE 826
WVKIDL LLSR+P H + P K++ + P T+ T EK PK KRK K
Sbjct: 802 WVKIDLDLLSRVPGHSSLH-AAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEV 860
Query: 827 DDYREIKKSQGEKDSSSRL---ATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPL 883
+ KK + E+ ++ L S + + N +S K EK+ P+SPL
Sbjct: 861 AEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPL 920
Query: 884 SDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPK 918
+ + + N T +S KPK
Sbjct: 921 PEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPK 955
Score = 332 bits (852), Expect = 1e-90
Identities = 164/270 (60%), Positives = 213/270 (78%), Gaps = 12/270 (4%)
Query: 957 SNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGN 1016
S+ + +R KL FDD +ADY+MQEAK++KHKADA+ EKFGKA+NYA+AALSF ECGN
Sbjct: 1052 SSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGN 1111
Query: 1017 AMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMF 1076
AME+ P+E+KSPYTMYSETVEL+RYAMRLK + P A+ DK+LA LCYRCL+LLY RMF
Sbjct: 1112 AMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMF 1171
Query: 1077 RLKRDHAVKYSKALIDYFK-NSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGS 1135
+LK+DHA+KYS++L++YFK N+SK AQ PSPW ++GK+ TPSP+S N S + + G+
Sbjct: 1172 KLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKN--TPSPVSLN--NVSPINAMGN 1227
Query: 1136 LSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLL 1195
+N V+IPQRIH MAA+HV+IT+++L Y++W+MAD L +EN+EFF DLD L
Sbjct: 1228 CNNGP-------VTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTL 1280
Query: 1196 MGPVTLHSSMEHLVQYSQQGLHWLRNSAHL 1225
MGP+T HSSM +LV+Y +QGL WLR AHL
Sbjct: 1281 MGPLTQHSSMTNLVRYVRQGLCWLRIDAHL 1310
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 77.0 bits (188), Expect = 1e-13
Identities = 112/615 (18%), Positives = 232/615 (37%), Gaps = 13/615 (2%)
Query: 333 NKDSQLVSSGHNNPKKGDAEPESPD-NGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRA 391
+ DS S +++ ++ +S D N +S++ + D SSD + ++ + ++ +
Sbjct: 549 SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSS 608
Query: 392 LSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP 451
S + + + SSK S SS S S S SSDS SS SD+ S SS S S
Sbjct: 609 DSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDS 668
Query: 452 HFSSPEAEPASS--NKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGK 509
SS ++ +SS + D + + + ++S S+S+ + + D
Sbjct: 669 SDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728
Query: 510 VPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPC 569
S + ++ + S S + + + ++ +
Sbjct: 729 SNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDS 788
Query: 570 APAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRP 629
+ + ++ + S + ++ + + D + + + ++D+ +S +
Sbjct: 789 SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848
Query: 630 CGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYP 689
G++ S + SS + + + S S ESS+SS SSDS S+ +
Sbjct: 849 DGSDSDSSNRS-DSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSD 907
Query: 690 LSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFG 749
S + + S++S + ++ N S S N+ +SD + +
Sbjct: 908 SSNSSDSSDSSNSSDSSESSNSSDNSNSS-----DSSNSSDSSDSSDSSNSSDSSNSSDS 962
Query: 750 RNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTP 809
N S +S + D + S + S+ ++ S+S+ S++SD+
Sbjct: 963 SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 810 AEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPI 869
S + D + S DSS+ +S S+ S + + + + +
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082
Query: 870 NKNEKMLRSPISPLSDASKHKYTSEDLTSS----SRPNGNSLFTSASSSKKPKADSQLQP 925
++ S S SD+S +S+ SS S + NS +S SS +DS
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142
Query: 926 HGGDLTKAAHNNSEN 940
D ++++ ++ +
Sbjct: 1143 DSSDSSESSDSSDSS 1157
Score = 76.6 bits (187), Expect = 1e-13
Identities = 125/631 (19%), Positives = 231/631 (36%), Gaps = 30/631 (4%)
Query: 333 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRAL 392
+ DS+ SS N+ D S + +SN+S D SSD ++ + + +
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD----SSDSSDSSSSSDSSNSSDSS 690
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPH 452
S S SS SS SS S+S+SSDS+SS+ SDS S+SS+S S
Sbjct: 691 DSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSS 750
Query: 453 FSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPD 512
SS ++ + S+ + + + S+ S+SN N D D D
Sbjct: 751 NSSDSSDSSDSSN------SSDSSDSSDSSDSSDSSNSSDSNDSSN--SSDSSDSSNSSD 802
Query: 513 VCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPA 572
S S+ + ++ + S S + + + + + +
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSD-------SDS 855
Query: 573 ENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGN 632
N + S + + + + D ++ + E ++D+ +S + + + +
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSN--ESSNSSDSSDSSNSSDSDSSDS----S 909
Query: 633 NRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSK 692
N + SS + E + S S ++SS SS+SSDS S+ S
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969
Query: 693 AQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNE 752
+ S+ S N +++ + S + S N+ +SD + + +
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSS--NSSDSSNSS 1025
Query: 753 LLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEK 812
S DS + D + S + S+ ++ S+S+ S +SD+
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS 1085
Query: 813 ALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKN 872
S + D + S DSS +S S+ S + + + + + + +
Sbjct: 1086 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145
Query: 873 EKMLRSPISPLSDASKHKYTSEDLTSS-SRPNGNSLFTSASSSKKPKADSQLQPHGGDLT 931
+ S S SD+S +S+ SS S + NS +S SS +DS D +
Sbjct: 1146 DSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1205
Query: 932 KAAHNNSENIPLHKSRPQTKPWSPGSNGHRD 962
++ ++ + S S SN D
Sbjct: 1206 DSSDSSDSSDSSDSSDSSDSSDSSDSNESSD 1236
Score = 76.3 bits (186), Expect = 2e-13
Identities = 124/636 (19%), Positives = 243/636 (38%), Gaps = 54/636 (8%)
Query: 333 NKDSQLVSSGHNNPKKGDAEP-ESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRA 391
+ DS S ++ D++ +S D+ SN+S + S + N ++ +
Sbjct: 692 SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN 751
Query: 392 LSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP 451
SDS+ + S SS S SS SS SS+SS ++SS+ SDS S+SS+S S
Sbjct: 752 SSDSS--DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV-KEDVQDCGKV 510
SS ++ SSN + S+ S+S+ N D D
Sbjct: 810 SDSSDSSDSDSSNS-------------------SDSSNSSDSSDSSNSSDSSDSSDSSDG 850
Query: 511 PDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA 570
D S R S+ + + + +S ++ + S ++ + +
Sbjct: 851 SD-SDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS 909
Query: 571 PAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPC 630
+ ++ + S + + ++ +++ D +N + ++D+ +S +
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD--SSDSSNSS-------DSSNSS 960
Query: 631 GNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPL 690
++ +S + SS + + + S S ++SS+SS SSDS S+
Sbjct: 961 DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSD 1020
Query: 691 SKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGR 750
S + ++++S +D + ++ S S N+ +SD + +
Sbjct: 1021 SSNSSDSSNSSDSSDSS-DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS------- 1072
Query: 751 NELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPA 810
S DS + D + S + S+ ++ S+S+ S++SD+
Sbjct: 1073 ----SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128
Query: 811 EKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPIN 870
S + D E S DSS +S S+ S + + N + + +
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 871 KNEKMLRSPISPLSDASKHKYTSEDLTSS-------SRPNGNSLFTSASSSKKPKADSQL 923
++ S S SD+S +S+ SS S + +S +S SS +DS
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSN 1248
Query: 924 QPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNG 959
D + ++ + S++ +S Q+K + +NG
Sbjct: 1249 SSDSSDSSDSSDSTSDS--NDESDSQSKSGNGNNNG 1282
Score = 75.5 bits (184), Expect = 3e-13
Identities = 113/603 (18%), Positives = 217/603 (35%), Gaps = 25/603 (4%)
Query: 340 SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQ 399
S N+ D+ S + +S++S + D S + + + + + S
Sbjct: 596 SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD 655
Query: 400 QPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE 459
+ S SS S SS SS SSSSS S SS SDS S+SSES S S
Sbjct: 656 SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS 715
Query: 460 PASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV-KEDVQDCGKVPDVCQPSL 518
SSN D + + N S S+S+ N D D D S
Sbjct: 716 SDSSNSNSSDSDSSNSSDSSDS---SNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 519 REKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAP 578
S+ + + + S ++ + S ++ + + + N+
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS 832
Query: 579 ARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHR 638
+ S + ++ + D + +R + ++D+ +S +S+
Sbjct: 833 SDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS----------------DSSNS 876
Query: 639 KELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAA 698
+ S + S S + ++SS+SS SSDS S+ E S + ++
Sbjct: 877 SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936
Query: 699 SASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLK 758
+S+ +D ++N + S ++ ++ + + + + ++
Sbjct: 937 DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD 996
Query: 759 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 818
SD S D + S + S+ ++ S+S+ S +SD+ S
Sbjct: 997 SSDSSNS----SDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 819 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 878
+ D + S DSS +S S+ S + + + + + + ++ S
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1112
Query: 879 PISPLSDASKHKYTSEDLTSS-SRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNN 937
S SD+S +S+ SS S + NS +S SS +DS D + ++ ++
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS 1172
Query: 938 SEN 940
+
Sbjct: 1173 DSS 1175
Score = 73.6 bits (179), Expect = 1e-12
Identities = 116/620 (18%), Positives = 234/620 (37%), Gaps = 68/620 (10%)
Query: 341 SGHNNPKKGDAE---PESPDNGTSNTSM--LEDDLKLSSD--------------EEENEQ 381
S +N+ +GDA ES DNG + S +DD +SD ++ ++
Sbjct: 481 SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKS 540
Query: 382 QAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESS 441
+ + + + SDS+ + + S S S+SSS S SS SDS SS SDS S+
Sbjct: 541 DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSN 600
Query: 442 SSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVK 501
SS+S S SS ++ + S +++S SES+ + K
Sbjct: 601 SSDSSDSSDSSDSSDSSDSSDS---------------------KSDSSKSESDSSDSDSK 639
Query: 502 EDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAA 561
D D + S + ++ + S S + + + +++
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699
Query: 562 APPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVP 621
+ + ++++ + ++ + + + + D +N ++D+ +S
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN--------SSDSSDSSDSSN 751
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
+ +N + SS + + + + S + SS SS+SSDS
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD 811
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQ 741
S+ + S + + S+ S + +++ + S + S N +S+ + +
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 742 FYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAP 801
+ S DS+E + D + S S+ ++ S+S+
Sbjct: 872 -----DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSD----------SSDSSNSSDSSD 916
Query: 802 PSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMN 861
S++SD+ + N D + S DSS+ S+ ++ S++ + N
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN----SSDSSNSSDSSDSN 972
Query: 862 INSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSS-SRPNGNSLFTSASSSKKPKAD 920
+ + N ++ S S SD+S +S+ SS S + NS +S SS +D
Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 921 SQLQPHGGDLTKAAHNNSEN 940
S D + ++ ++ +
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSS 1052
Score = 71.2 bits (173), Expect = 6e-12
Identities = 113/612 (18%), Positives = 226/612 (36%), Gaps = 25/612 (4%)
Query: 335 DSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 394
DS S +N+ G+ + DN S++ + D S + + + ++ SD
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD 573
Query: 395 SAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFS 454
S + S S S SS S +SS SSDS SS S ++SS S+S+ SK S
Sbjct: 574 SNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSK----S 629
Query: 455 SPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVC 514
++ + S D + + + N S+ S+S+ D D D
Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD-----SSDSSDSSSSSDSS 684
Query: 515 QPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAEN 574
S S+ E + + S S S ++ + + + +
Sbjct: 685 NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN--------SNSSDSDSSNSSDSSD 736
Query: 575 APAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNR 634
+ + S + ++ + + D +N + + + S + ++
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796
Query: 635 ASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQ 694
+S+ + +S S S ++SS SS+SSDS S+ + S +
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Query: 695 TVAASASSGNDQRLKEAAANGGSGPRAPVG-SINARTTSDIAKELEEQFYTLVPFGRNEL 753
+ S++S + +++ + S + S N+ +SD + + +
Sbjct: 857 NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD 916
Query: 754 LSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKA 813
S DS E + + + S + S+ ++ S+S+ S +SD+ + +
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 814 LPKSKRKRKCDNED-----DYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIP 868
S D+ D D + S DSS +S S+ S + + N + +
Sbjct: 977 SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 1036
Query: 869 INKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGG 928
+ ++ S S SD+S +S+ +S S + +S +S SS +DS +
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSD--SSDSSDSSDSSDSSDSSDSSESSDSSDSSNSS 1094
Query: 929 DLTKAAHNNSEN 940
D + ++ ++ +
Sbjct: 1095 DSSDSSDSSDSS 1106
Score = 69.7 bits (169), Expect = 2e-11
Identities = 113/614 (18%), Positives = 225/614 (36%), Gaps = 47/614 (7%)
Query: 333 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEE-----NEQQAAQRT 387
+ DS S+ +++ +S D+ S+ S D SSD + N ++ +
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 388 ALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEG 447
SDS+ N ++ S SS+SS S +SS SSDS SS SDS S SS S
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831
Query: 448 SKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV-KEDVQD 506
S SS ++ + S+ N+ + N S S+S+ N D D
Sbjct: 832 SSDSSNSSDSSDSSDSSDGSDSDSSNRSDS-------SNSSDSSDSSDSSNSSDSSDSSD 884
Query: 507 CGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 566
+ + S S + ++ + S + S + + + ++ +
Sbjct: 885 SNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS 944
Query: 567 VPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTK 626
+ + N+ + S + ++ S+ + + + ++D+ +S
Sbjct: 945 SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD-------- 996
Query: 627 TRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQE 686
++ ++ SS + + + S S ++SS SS SSDS S+
Sbjct: 997 ----SSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 687 EYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLV 746
+ S + ++ +S +D +++ + S N+ +SD + +
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS-NSSDSSDSSDSSDS------ 1105
Query: 747 PFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTS 806
S DS + D + S + S+ ++ S+S+ S +S
Sbjct: 1106 --------SDSSDSSD------SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS 1151
Query: 807 DTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVA 866
D+ S + D + S DSS +S S+ S + + + + +
Sbjct: 1152 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1211
Query: 867 IPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPH 926
+ ++ S S SD+++ S D + SS + +S + +S S +DS +
Sbjct: 1212 DSSDSSDSSDSSDSSDSSDSNESS-DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESD 1270
Query: 927 GGDLTKAAHNNSEN 940
+ +NN +
Sbjct: 1271 SQSKSGNGNNNGSD 1284
Score = 60.5 bits (145), Expect = 1e-08
Identities = 116/645 (17%), Positives = 234/645 (36%), Gaps = 73/645 (11%)
Query: 318 IQAPG-KVEP-TKFPFPNKDSQLVSSGHNN------PKKGDAEPESPD--NG-------T 360
I+ PG K EP K N S S G+++ +GD +P S D NG +
Sbjct: 423 IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGD-DPNSSDESNGNDDANSES 481
Query: 361 SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG 420
N S D +SDE ++ + + N ++ + G+ + S
Sbjct: 482 DNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSD 541
Query: 421 SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKP 480
S SDS S SDS S SS+S S +S +S +
Sbjct: 542 SGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS---------------- 585
Query: 481 PILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAP 540
+ S S+S+ + D D D S + K E ++
Sbjct: 586 -----DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640
Query: 541 GS--KGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGD 598
S S + + + +++ + + + ++ + + S + ++ +++ +
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSE 700
Query: 599 GANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRI 658
++ + ++D+ +S + + ++ +S+ + SS + + + S
Sbjct: 701 SSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSD--SSDSSDSSNSSDSSDS 758
Query: 659 VPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASAS-SGNDQRLKEAAANGGS 717
S ++SS SS SSDS S+ + S + ++++S S N +++ + S
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDS 818
Query: 718 GPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSR 777
S N+ +SD + + + G + S DS
Sbjct: 819 DSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN--------------- 863
Query: 778 IPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDN--EDDYREIKKS 835
S+ ++ S+S+ S +SD+ S N + D + S
Sbjct: 864 ------------SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS 911
Query: 836 QGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSED 895
DSS+ +S S+ S N + + ++ + + ++ S S SD+S +S+
Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 971
Query: 896 LTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSEN 940
+S S + NS +S SS +DS + D + ++ ++ +
Sbjct: 972 NSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1016
Score = 47.8 bits (112), Expect = 7e-05
Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 1/119 (0%)
Query: 340 SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQ 399
SS ++ +S D+ S+ S D SSD ++ + + + S
Sbjct: 1183 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSD 1242
Query: 400 QPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETES-SSSESEGSKPPHFSSPE 457
+ S SS S SS S+ S+ SDS+S SG+ + S S S+SEGS H +S +
Sbjct: 1243 SSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 20/164 (12%)
Query: 333 NKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLED--DLKLSSDEEENEQQAAQRTALR 390
+ DS S ++ D+ S + +SN+S D D SSD ++ + +
Sbjct: 1150 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS-- 1207
Query: 391 ALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKP 450
SDS+ + + S SS S+ S SS SSDS SS S ++SS S S
Sbjct: 1208 --SDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDS 1265
Query: 451 PHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESN 494
S +++ + N D ++S GS+SN
Sbjct: 1266 NDESDSQSKSGNGNNNGSDS--------------DSDSEGSDSN 1295
Score = 35.4 bits (80), Expect = 0.34
Identities = 126/633 (19%), Positives = 224/633 (35%), Gaps = 74/633 (11%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALS 393
+D V+ +N+ D E+ NTS + + S E + T A
Sbjct: 181 EDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQIN-SKRNGTKEAEVTPGTGEDAGL 239
Query: 394 DSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESE--GSKPP 451
D++ PS G+ GS D E+ +G DS S E + G +
Sbjct: 240 DNS--------DGSPSGNGADEDEDEGSGDDE-DEEAGNGKDSSNNSKGQEGQDHGKEDD 290
Query: 452 HFSS------------PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN- 498
H SS PE + N+ DK +K + I N S E Q N
Sbjct: 291 HDSSIGQNSDSKEYYDPEGKEDPHNEVDGDK-TSKSEENSAGIPEDNGSQRIEDTQKLNH 349
Query: 499 ----PVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAV 554
V+ + + V + + EIK R T G++G + K +
Sbjct: 350 RESKRVENRITKESETHAVGKSQDKGIEIKGP-SSGNRNITKEVGKGNEGKEDKGQHGMI 408
Query: 555 AVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADAL 614
+ V N P ++S +P + ++ G +N + + D
Sbjct: 409 LGKGNVKTQGEVV------NIEGPGQKS---EPGNKVGHSNTGSDSNSDGYD---SYDFD 456
Query: 615 GTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRG-LSRIVPKSKEFIETESSSS 673
S+ + GN+ A+ + SS +RG S +SK+ S
Sbjct: 457 DKSMQGDDPNSSDESNGNDDANSESDNNSS-------SRGDASYNSDESKDNGNGSDSKG 509
Query: 674 SSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD 733
+ DSD S+ + + ++GND K + G S + S ++ +SD
Sbjct: 510 AEDDDSDSTSDTNNSDSN------GNGNNGNDDNDKSDSGKGKS-DSSDSDSSDSSNSSD 562
Query: 734 IAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPA 793
+ + + S SD S D + S + S+ +
Sbjct: 563 SSDSSDSD------SSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616
Query: 794 TKDSESAPPSHTSDTPAEKALPK--SKRKRKCDNED--DYREIKKSQGEKDS--SSRLAT 847
+ S+S S S++ + + K S D+ D D + S DS SS +
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676
Query: 848 STSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSL 907
S+S++ S+N + + +S + +++ S S SD+S S + SS + NS
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS----DSSNSNSSDSDSSNSS 732
Query: 908 FTSASSSKKPKADSQLQPHGGDLTKAAHNNSEN 940
+S SS+ +DS + D + ++ +++ +
Sbjct: 733 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSS 765
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 70.1 bits (170), Expect = 1e-11
Identities = 129/585 (22%), Positives = 200/585 (34%), Gaps = 92/585 (15%)
Query: 262 TSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPP------- 314
T +G + P A A A +K P++ ES S E++ EE L
Sbjct: 310 TPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS 369
Query: 315 -LSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLS 373
+ A AP K P K P G P A+ E+D + S
Sbjct: 370 QVGAASAPAKESPRKGAAP------APPGKTGPAVAKAQ----------AGKREEDSQSS 413
Query: 374 SDEEENEQQAAQRTA-------LRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 426
S+E ++E++A + +RA S A P K +++
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Query: 427 DSESSSG-SDSETESSSSESEGSKPPHFSSPEAEPASS-NKWQLDKWL-----NKVNPHK 479
DS SSS SDS+ E+ ++ + P SP+ +PAS+ L K KV P
Sbjct: 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 480 PPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKA 539
P + SES+ + D G+VP P+ +EK + + + + A
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSD----GEVPTAVAPA-QEKSLGNILQAKPTSSPA--- 585
Query: 540 PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDG 599
KG QK+ P AV V +KP +E +S
Sbjct: 586 ---KGPPQKAGPVAVQV--------------------------KAEKPMDNSE-SSEESS 615
Query: 600 ANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIV 659
+ E PAA A + TK P N + K V + R G +
Sbjct: 616 DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 675
Query: 660 PKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA----ANG 715
S + + + S S ES+ EE A TV + S G ++K A+ +
Sbjct: 676 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 735
Query: 716 GSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLL 775
G G + T + + E +E +E DS+E + ++ ++
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQED---------SESSEEESDSEEAAASPAQVKTSVK 786
Query: 776 SRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRK 820
P AP+ K + SAP + K SK K
Sbjct: 787 K---TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK 828
Score = 64.7 bits (156), Expect = 5e-10
Identities = 154/755 (20%), Positives = 255/755 (33%), Gaps = 127/755 (16%)
Query: 126 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 184
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 185 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 232
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 233 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 292
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 293 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 351
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 352 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 405
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 406 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 464
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 969
Query: 465 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 519
P P Q ++ SES + + + +D P +R
Sbjct: 970 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 520 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVS---AAAPP 564
+ PR A KA S G KQ+ P V AV A +P
Sbjct: 1019 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 565 PAVPCAPAEN----APAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVV 620
A N P + A K P + + D ++ + A +V
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLV 1135
Query: 621 PPEPTKTRPCGNNRASHRKE----LRSSVTCEKRRTRGL----SRIVPKSKEFIETESSS 672
P P++T A+ E S T GL S+ + + + S S
Sbjct: 1136 GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVS 1195
Query: 673 SSSSSDSDLESEQEEYPLSKA-----QTVAASASSGNDQRLKEAAANGGSGPRAPVGSIN 727
S+ ++ D + +QE P A +T A+SG + G P+A ++
Sbjct: 1196 STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQ 1255
Query: 728 ARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPG 787
+ T + + P+ NE ++++ VK+ L + + +
Sbjct: 1256 SNITQCLLGQ---------PWPLNEA--------QVQASVVKV---LTELLEQERKKVVD 1295
Query: 788 VLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRK 822
+ K ES + D PA + P+SK+K+K
Sbjct: 1296 TTKESSRKGWESRKRKLSGDQPAART-PRSKKKKK 1329
Score = 63.2 bits (152), Expect = 2e-09
Identities = 170/927 (18%), Positives = 312/927 (33%), Gaps = 107/927 (11%)
Query: 74 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 133
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 134 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 193
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 194 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 253
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 254 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 305
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 306 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 364
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 365 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 415
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 416 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 473
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 474 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 526
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 527 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 583
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 584 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 639
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 640 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 699
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 700 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 758
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 759 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 818
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 819 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 878
+ K D+ E S GE ++ A I I ++ N RS
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSA-------------QVIKPPLIFVDPN----RS 967
Query: 879 PISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNS 938
P P + ++ + +S+ + ++A SS D + P LT N
Sbjct: 968 PAGPAATPAQAQ------AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 939 ENIPLHKSRPQTKPWSPGSNGHRDCKR 965
+P R K G++ ++ R
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSR 1048
Score = 58.9 bits (141), Expect = 3e-08
Identities = 191/993 (19%), Positives = 335/993 (33%), Gaps = 151/993 (15%)
Query: 221 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 278
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 279 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 338
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 339 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 394
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 395 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 453
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 454 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 513
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 514 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 567
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 568 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 625
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 626 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 682
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 683 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 740
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Query: 741 QFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESA 800
+ +E S D E+ + L I + P S+PA + A
Sbjct: 544 DSES-----SSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKP-----TSSPAKGPPQKA 592
Query: 801 PPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNM 860
P AEK + S+ + + D E + + L + N
Sbjct: 593 GPV-AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA-CPKKTNT 650
Query: 861 NINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKAD 920
++ P+ + R + S A SS G + + SS ++D
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTATSPAG----------SSPAVAGGTQRPAEDSSSSEESD 700
Query: 921 SQLQPHGGDLT--------KAAHNNSENIPLHKSRPQ-TKPWSPGSNG------------ 959
S+ + G +T K + ++P+ S Q T P PG G
Sbjct: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
Query: 960 HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFI-ECGNAM 1018
+ ++ ++ S K+ + KA+ + A A + A
Sbjct: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
Query: 1019 EQGPMESKSPYTMYSETVELIR-----------YAMRLKTHSGP---NATPEDKQLAALC 1064
++ P + K P + L R A + +GP + + E++ +
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 1065 YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNP 1124
LA ++K +A + K S + AP+P G +G S +
Sbjct: 881 AETLA-------QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Query: 1125 SPASSVGSQG----SLSNASALSPSTIVSIPQR 1153
S + S G ++++A + P I P R
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 966
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 70.1 bits (170), Expect = 1e-11
Identities = 129/585 (22%), Positives = 200/585 (34%), Gaps = 92/585 (15%)
Query: 262 TSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPP------- 314
T +G + P A A A +K P++ ES S E++ EE L
Sbjct: 310 TPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS 369
Query: 315 -LSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLS 373
+ A AP K P K P G P A+ E+D + S
Sbjct: 370 QVGAASAPAKESPRKGAAP------APPGKTGPAVAKAQ----------AGKREEDSQSS 413
Query: 374 SDEEENEQQAAQRTA-------LRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 426
S+E ++E++A + +RA S A P K +++
Sbjct: 414 SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Query: 427 DSESSSG-SDSETESSSSESEGSKPPHFSSPEAEPASS-NKWQLDKWL-----NKVNPHK 479
DS SSS SDS+ E+ ++ + P SP+ +PAS+ L K KV P
Sbjct: 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
Query: 480 PPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKA 539
P + SES+ + D G+VP P+ +EK + + + + A
Sbjct: 534 PSAQVGKWEEDSESSSEESSDSSD----GEVPTAVAPA-QEKSLGNILQAKPTSSPA--- 585
Query: 540 PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDG 599
KG QK+ P AV V +KP +E +S
Sbjct: 586 ---KGPPQKAGPVAVQV--------------------------KAEKPMDNSE-SSEESS 615
Query: 600 ANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIV 659
+ E PAA A + TK P N + K V + R G +
Sbjct: 616 DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 675
Query: 660 PKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA----ANG 715
S + + + S S ES+ EE A TV + S G ++K A+ +
Sbjct: 676 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 735
Query: 716 GSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLL 775
G G + T + + E +E +E DS+E + ++ ++
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQED---------SESSEEESDSEEAAASPAQVKTSVK 786
Query: 776 SRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRK 820
P AP+ K + SAP + K SK K
Sbjct: 787 K---TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK 828
Score = 63.2 bits (152), Expect = 2e-09
Identities = 170/927 (18%), Positives = 312/927 (33%), Gaps = 107/927 (11%)
Query: 74 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 133
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 134 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 193
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 194 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 253
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 254 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 305
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 306 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 364
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 365 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 415
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 416 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 473
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 474 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 526
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 527 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 583
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 584 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 639
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 640 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 699
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 700 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 758
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 759 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 818
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 819 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 878
+ K D+ E S GE ++ A I I ++ N RS
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSA-------------QVIKPPLIFVDPN----RS 967
Query: 879 PISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNS 938
P P + ++ + +S+ + ++A SS D + P LT N
Sbjct: 968 PAGPAATPAQAQ------AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 939 ENIPLHKSRPQTKPWSPGSNGHRDCKR 965
+P R K G++ ++ R
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSR 1048
Score = 60.5 bits (145), Expect = 1e-08
Identities = 157/760 (20%), Positives = 259/760 (34%), Gaps = 138/760 (18%)
Query: 126 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 184
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 185 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 232
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 233 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 292
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 293 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 351
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 352 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 405
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 406 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 464
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 969
Query: 465 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 519
P P Q ++ SES + + + +D P +R
Sbjct: 970 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 520 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVS---AAAPP 564
+ PR A KA S G KQ+ P V AV A +P
Sbjct: 1019 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 565 PAVPCAPAEN----APAPARRSAGKKP-----TRRTERTSAGDGANCHRPEEPAAADALG 615
A N P + A K P + + +S+G + P+ +A LG
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG 1135
Query: 616 TSVVVPPEPTKTRPCGNNRASHRKE----LRSSVTCEKRRTRGL----SRIVPKSKEFIE 667
P P++T A+ E S T GL S+ + +
Sbjct: 1136 ------PTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDS 1189
Query: 668 TESSSSSSSSDSDLESEQEEYPLSKA-----QTVAASASSGNDQRLKEAAANGGSGPRAP 722
+ S SS+ ++ D + +QE P A +T A+SG + G P+A
Sbjct: 1190 SPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAS 1249
Query: 723 VGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHL 782
++ + T + + P+ NE ++++ VK+ L + +
Sbjct: 1250 TLALQSNITQCLLGQ---------PWPLNEA--------QVQASVVKV---LTELLEQER 1289
Query: 783 PQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRK 822
+ + K ES + D PA + P+SK+K+K
Sbjct: 1290 KKVVDTTKESSRKGWESRKRKLSGDQPAART-PRSKKKKK 1328
Score = 58.9 bits (141), Expect = 3e-08
Identities = 191/993 (19%), Positives = 335/993 (33%), Gaps = 151/993 (15%)
Query: 221 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 278
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 279 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 338
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 339 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 394
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 395 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 453
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 454 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 513
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 514 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 567
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 568 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 625
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 626 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 682
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 683 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 740
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Query: 741 QFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESA 800
+ +E S D E+ + L I + P S+PA + A
Sbjct: 544 DSES-----SSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKP-----TSSPAKGPPQKA 592
Query: 801 PPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNM 860
P AEK + S+ + + D E + + L + N
Sbjct: 593 GPV-AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA-CPKKTNT 650
Query: 861 NINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKAD 920
++ P+ + R + S A SS G + + SS ++D
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTATSPAG----------SSPAVAGGTQRPAEDSSSSEESD 700
Query: 921 SQLQPHGGDLT--------KAAHNNSENIPLHKSRPQ-TKPWSPGSNG------------ 959
S+ + G +T K + ++P+ S Q T P PG G
Sbjct: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
Query: 960 HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFI-ECGNAM 1018
+ ++ ++ S K+ + KA+ + A A + A
Sbjct: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
Query: 1019 EQGPMESKSPYTMYSETVELIR-----------YAMRLKTHSGP---NATPEDKQLAALC 1064
++ P + K P + L R A + +GP + + E++ +
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 1065 YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNP 1124
LA ++K +A + K S + AP+P G +G S +
Sbjct: 881 AETLA-------QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Query: 1125 SPASSVGSQG----SLSNASALSPSTIVSIPQR 1153
S + S G ++++A + P I P R
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 966
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 68.9 bits (167), Expect = 3e-11
Identities = 107/502 (21%), Positives = 185/502 (36%), Gaps = 60/502 (11%)
Query: 265 RGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEII-REMTWLPPLSAIQAPGK 323
R + A+ P +AK K S EE + + + + LPP A +
Sbjct: 66 RKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASE 125
Query: 324 VEPTKFPFPNKDS-----QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEE 378
++ + D Q V G K P P S+ S D SS++E
Sbjct: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAP--PKKAKSSDS----DSDSSSEDEP 179
Query: 379 NEQQAAQRTALRALSDSAVVQQP-NCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSE 437
+ Q + T + + + +P + + K +SSSSSS SSSSS DSE + +
Sbjct: 180 PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
Query: 438 TESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYY 497
++ + +K P ++ SS+ +S E +
Sbjct: 240 KKTVPKKQVVAKAPVKAATTPTRKSSS--------------------SEDSSSDEEEEQK 279
Query: 498 NPVKEDVQDCGKVPDVCQP----SLREKEIKSTCKEEQRPRTANKA---PGSKGVKQKSP 550
P+K VP P SL + K +++Q ++ + S ++K P
Sbjct: 280 KPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP 339
Query: 551 PAAVAVAVSAAAPPPAVPCAPAENAPAPARRS----AGKKPTRRTERTSAGDGANCHRPE 606
P V+ + PPPA A + + + + S A KP T+ +S P
Sbjct: 340 PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPA 399
Query: 607 -EPAAADAL----GTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 661
+PAAA G ++ + + ++ + K + T + + T + +P
Sbjct: 400 VKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPA 459
Query: 662 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAA--NGGSGP 719
+ S SSSDSD S +EE + + SA Q++ AA S
Sbjct: 460 K----QAPQGSRDSSSDSDSSSSEEE-----EEKTSKSAVKKKPQKVAGGAAPSKPASAK 510
Query: 720 RAPVGSINARTTSDIAKELEEQ 741
+ S N+ ++ D ++E EE+
Sbjct: 511 KGKAESSNSSSSDDSSEEEEEK 532
Score = 64.7 bits (156), Expect = 5e-10
Identities = 144/660 (21%), Positives = 231/660 (35%), Gaps = 105/660 (15%)
Query: 102 QTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAA-VPVQQSKRGTMGWQKAGHPPSDGQQ 160
+ P K+ + +A+ + SS S +S V +K+ + ++ G PP
Sbjct: 62 KVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAA 121
Query: 161 RATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSL 220
+A++ S D Q + +Q +P A AAK PP
Sbjct: 122 KASESSSSEESSDDDDEEDQKKQP--------VQKGVKPQAKAAKA----------PPKK 163
Query: 221 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAK 280
A D + DE PK + T V + P P+PARA K
Sbjct: 164 AKSSD------------SDSDSSSEDEPPKNQKPKITPVTVKAQTKAP---PKPARAAPK 208
Query: 281 LSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVS 340
++ S S ++ EE A P K P K Q+V+
Sbjct: 209 IANGKAASSSSSSSSSSSSDDSEEE----------KAAATPKKTVPKK--------QVVA 250
Query: 341 SGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD----SA 396
P K P T +S ED SS +EE EQ+ + S SA
Sbjct: 251 KA---PVKAATTP------TRKSSSSED----SSSDEEEEQKKPMKNKPGPYSSVPPPSA 297
Query: 397 VVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGS-KPPHFSS 455
+ + T P S SS +S+SSS + + + + S+ + KPP +
Sbjct: 298 PPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP--PA 355
Query: 456 PEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHG---SESNQYYNPVKEDVQDCGKVPD 512
+A +SS+ D + P KP +N S+ + + P Q G
Sbjct: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG-- 413
Query: 513 VCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPA 572
Q L K S+ +EE K K V P A A+S PA
Sbjct: 414 --QKLLTRKADSSSSEEESSSSEEEKT--KKMVATTKPKATAKAALSL----------PA 459
Query: 573 ENAPAPARRSAGKKPTRRTERTS--AGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPC 630
+ AP +R S+ + +E A +P++ A A P +P +
Sbjct: 460 KQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAA-------PSKPASAKK- 511
Query: 631 GNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPL 690
G +S+ S E+ + +G P++ + T S+ ++ + + SE+EE
Sbjct: 512 GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGT-SALTAQNGKAAKNSEEEEEEK 570
Query: 691 SKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGR 750
KA V + + S ++ EAA P+A I +T + K + + PF R
Sbjct: 571 KKAAVVVSKSGSLKKRKQNEAAKEA-ETPQAK--KIKLQTPNTFPKRKKGEKRASSPFRR 627
Score = 55.5 bits (132), Expect = 3e-07
Identities = 131/638 (20%), Positives = 211/638 (33%), Gaps = 149/638 (23%)
Query: 395 SAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFS 454
SA V + + + P +K + +SS S SS+ E +++ PP +
Sbjct: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA 119
Query: 455 SPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVC 514
+ +A +SS++ ++ E +Q PV++ V+ K
Sbjct: 120 AAKASESSSSE-------------------ESSDDDDEEDQKKQPVQKGVKPQAKAAKAP 160
Query: 515 QPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAEN 574
+ + S E P K K K P V V APP PA
Sbjct: 161 PKKAKSSDSDSDSSSEDEP--------PKNQKPKITP--VTVKAQTKAPPK-----PARA 205
Query: 575 APAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGT---SVVVPPEPTK----- 626
AP A A + + +S+ D EE AAA T VV P K
Sbjct: 206 APKIANGKAASSSSSSSSSSSSDDSE-----EEKAAATPKKTVPKKQVVAKAPVKAATTP 260
Query: 627 TRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKS-------------KEFIETES--- 670
TR ++ S E K + S + P S K+ +E +
Sbjct: 261 TRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVE 320
Query: 671 SSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINART 730
SS SS +SD SE+E+ P +KA A+ + P A +
Sbjct: 321 SSEDSSDESDSSSEEEKKPPTKAVVSKATT-------------------KPPPAKKAAES 361
Query: 731 TSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLS 790
+SD + DSD S + P +P
Sbjct: 362 SSDSS-----------------------DSD--------------SSEDDEAPSKP---- 380
Query: 791 APATKDSESAPPSHTSDTPAEKALPKSKRK---------RKCDNEDDYREIKKSQGEKDS 841
A TK+S S P+ T+ +PA K K+ RK D+ E S+ EK
Sbjct: 381 AGTTKNS-SNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 842 SSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSR 901
T T A ++++P + + R S SD+S + E + S+
Sbjct: 440 KMVATTKPKATAKA--------ALSLPAKQAPQGSRDSSSD-SDSSSSEEEEEKTSKSAV 490
Query: 902 PNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHR 961
++ KP + + + + + + ++ E K + +P +P +NG
Sbjct: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTS 550
Query: 962 DCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFG 999
Q A +E + K KA +V K G
Sbjct: 551 ALTAQN-------GKAAKNSEEEEEEKKKAAVVVSKSG 581
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 66.6 bits (161), Expect = 1e-10
Identities = 102/384 (26%), Positives = 149/384 (38%), Gaps = 61/384 (15%)
Query: 135 AVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK----QVCNVE 190
A+ V +KR + K DG +++ + G GR+ P AK + +E
Sbjct: 2294 ALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKAR---GRGRK-PSAKAKGDRAATLE 2349
Query: 191 VGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQ-----AP 245
G T E P A SS + PP K + + A +P AP
Sbjct: 2350 EGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAP 2409
Query: 246 DESPKLKSSSETSVHCTSYRGVPASKPEPARAKA-KLSKFSIPKQ-GEESR--------- 294
+ +L + + TS+ +PA++P+P +A+A + S P++ GEE+
Sbjct: 2410 EPFAELPAPA-TSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEG 2468
Query: 295 --SGETNSCVEEIIREMT-----WLPPLSAIQ------APGKVEPTKFPFPNK-DSQLV- 339
S ++ E ++ W P S + A G EP K P+P D L
Sbjct: 2469 VTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEP-KAPWPKATDGDLAQ 2527
Query: 340 ----------SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSD----------EEEN 379
S +P K AE + + S++S SS EEE
Sbjct: 2528 EPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEG 2587
Query: 380 EQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETE 439
++ + SA + S SS SSSSSSS SSSSSS S SSS S S +
Sbjct: 2588 DKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647
Query: 440 SSSSESEGSKPPHFSSPEAEPASS 463
SSSS S S SS + +SS
Sbjct: 2648 SSSSSSSSSSSSSSSSSSSSSSSS 2671
Score = 38.9 bits (89), Expect = 0.030
Identities = 91/447 (20%), Positives = 151/447 (33%), Gaps = 63/447 (14%)
Query: 564 PPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAA----------ADA 613
PP AE +PA SA ++ + ++ T G EEP A A A
Sbjct: 2281 PPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGRGRKPSAKA 2340
Query: 614 LGTSVVV-----PPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIET 668
G P + + P +S +S +R + PK++
Sbjct: 2341 KGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKA-----PKARPAPPQ 2395
Query: 669 ESSSSSSSSDSDLESEQEEYP-----LSKAQTVAASASSGNDQRLKEAAANGGSGPRAP- 722
S + + + E P L+ A + A+ ++ + A +G GPR P
Sbjct: 2396 PSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPG 2455
Query: 723 ------VGSINARTTSDIAKELEEQFYTLVPFGRN------ELLS-----PLKDSDEIRS 765
V + TS +K+ +E G LLS P S E ++
Sbjct: 2456 EEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKA 2515
Query: 766 LWVKIDLTLLSRIP--------EHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKS 817
W K L++ P P+ P A A +D S +S + + S
Sbjct: 2516 PWPKATDGDLAQEPGPGLTFEDSGNPKSPD--KAQAEQDGAEESESSSSSSSGSSSSSSS 2573
Query: 818 KRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLR 877
+ E + K G + R ++ S+ ++ + + +S + + +
Sbjct: 2574 SSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSS 2633
Query: 878 SPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQ--------PHGGD 929
S S S +S +S +SSS + +S +S+SSS DS P G
Sbjct: 2634 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGP 2693
Query: 930 LTKAAHNNSENIPLHKSRPQTKPWSPG 956
+AA K+RP SPG
Sbjct: 2694 SAQAALPTKATKQAGKARPSAH--SPG 2718
Score = 34.3 bits (77), Expect = 0.75
Identities = 36/138 (26%), Positives = 50/138 (36%), Gaps = 24/138 (17%)
Query: 559 SAAAPPPAVPCAPA-------ENAPAPARRSAG-----KKPTRRTERTSAGDGANCHRPE 606
SAAAP P V APA + P R+ AG K P ++ + AG GA P
Sbjct: 2008 SAAAPAP-VSTAPATKTSRCAKGGPLSPRKDAGRAKDRKDPRKKKKGKEAGPGAGLPPPR 2066
Query: 607 EPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFI 666
PA P + + A+ R + ++ K+ RG V K E +
Sbjct: 2067 APAL-----------PSEARAPHASSLTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESM 2115
Query: 667 ETESSSSSSSSDSDLESE 684
E + S E E
Sbjct: 2116 AAEEDFEPNQDSSFSEDE 2133
Score = 33.9 bits (76), Expect = 0.98
Identities = 97/507 (19%), Positives = 174/507 (34%), Gaps = 77/507 (15%)
Query: 231 PTAYVR--PMDGQDQAPDESPKL------KSSSETSVHCTSYR--GVPASKPEPARAKAK 280
P +++R P D + Q + SP L + S +TS + G S+ A+A+ +
Sbjct: 2273 PLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGR 2332
Query: 281 LSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDS-QLV 339
K S +G+ + + E + +E+ P +EP+ P K + V
Sbjct: 2333 GRKPSAKAKGDRAATLEEGNPTDEVP------------STPLALEPSSTPGSKKSPPEPV 2380
Query: 340 SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQ 399
PK A P+ + TS E A +L+ + ++
Sbjct: 2381 DKRAKAPKARPAPPQPSPAPPAFTSC-----------PAPEPFAELPAPATSLAPAPLIT 2429
Query: 400 QPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE 459
P R ++ + S + G ++E D E +S SK + E
Sbjct: 2430 MPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPK----SKKAKEALLLRE 2485
Query: 460 PASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 519
+ WQ K L + + P + GS + P D G + P L
Sbjct: 2486 DPGAGGWQEPKSLLSLGSYPP-------AAGSSEPKAPWPKATD----GDLAQEPGPGL- 2533
Query: 520 EKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPA 579
T ++ P++ +KA + ++S ++ + + S+++ + +
Sbjct: 2534 ------TFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSS--------------SSS 2573
Query: 580 RRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 639
S+G + E GDG +AA + S + + ++ +S
Sbjct: 2574 SSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSS 2633
Query: 640 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSS----DSDLESEQEEYPLSKAQT 695
SS + + S S + SSSSSSSS DS S+ E P A T
Sbjct: 2634 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAP---APT 2690
Query: 696 VAASASSGNDQRLKEAAANGGSGPRAP 722
SA + + + A +P
Sbjct: 2691 AGPSAQAALPTKATKQAGKARPSAHSP 2717
Score = 31.2 bits (69), Expect = 6.3
Identities = 36/190 (18%), Positives = 67/190 (35%), Gaps = 8/190 (4%)
Query: 540 PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDG 599
P + + K+P A P P + + N +P + A + +E +S+
Sbjct: 2506 PAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSS 2565
Query: 600 ANCHRPEEPAAADALGTSVVVPPEPTKTRP--CGN---NRASHRKELRSSVTCEKRRTRG 654
+ +++ + G+ E K CG N ++ S + +
Sbjct: 2566 GSS---SSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSS 2622
Query: 655 LSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAAN 714
S S + SSSSSSSS S S S + + ++S+SS +++
Sbjct: 2623 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSD 2682
Query: 715 GGSGPRAPVG 724
+ P G
Sbjct: 2683 DEAAPAPTAG 2692
>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 [Homo sapiens]
Length = 568
Score = 65.1 bits (157), Expect = 4e-10
Identities = 99/395 (25%), Positives = 147/395 (37%), Gaps = 66/395 (16%)
Query: 379 NEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET 438
N + +R L+A D PN R+ SS SSSSSSS SSSSSS S SSS S S +
Sbjct: 126 NPTEDFRRKLLKAGGD------PN-RSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 178
Query: 439 ESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN 498
SSSS S S FS P L K + KP +S ++ +
Sbjct: 179 SSSSSSSSSSSSTSFSKPHK-------------LMKEHKEKP---------SKDSREHKS 216
Query: 499 PVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPG--SKGVKQKSPPAAVAV 556
KE +D K + S + KE K +E+ P+ A K P SK K S +
Sbjct: 217 AFKEPSRDHNKSSK--ESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITS 274
Query: 557 AVSAAAPPPAVPCAPAENAPAPARR---------------------SAGKKPTRRTERTS 595
AP P + +E A R+ SA KK +
Sbjct: 275 GQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVK 334
Query: 596 AGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNR--------ASHRKELRSSVTC 647
G E + +V P + +++ AS SS T
Sbjct: 335 MGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTP 394
Query: 648 EKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSK--AQTVAASASSGND 705
+ R +G R + K + E S D+D +SE E P+++ +++ S S G+D
Sbjct: 395 SQTRQQGPLRSIMKDLHSDDNE-EESDEVEDNDNDSEMER-PVNRGGSRSRRVSLSDGSD 452
Query: 706 QRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 740
A++ P P+ N ++ +++
Sbjct: 453 SESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQ 487
Score = 38.5 bits (88), Expect = 0.040
Identities = 70/327 (21%), Positives = 129/327 (39%), Gaps = 49/327 (14%)
Query: 203 AAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCT 262
++ SSS + S +S S T++ +P + K K S ++ H +
Sbjct: 162 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEH-----KEKPSKDSREHKS 216
Query: 263 SYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPP-------- 314
+++ EP+R K SK S K E E E+I+ +M + P
Sbjct: 217 AFK-------EPSRDHNKSSKESSKKPKENKPLKE-----EKIVPKMAFKEPKPMSKEPK 264
Query: 315 -----LSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNG-------TSN 362
L+ K P+K P P DS+ +S+ +A +S + +++
Sbjct: 265 PDSNLLTITSGQDKKAPSKRP-PISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSAD 323
Query: 363 TSMLEDD--LKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG 420
++D +K+ + E+E +++ L D + PN + V + S S S
Sbjct: 324 KKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDD---IVDPN-DSDVEENISSKSDSEQP 379
Query: 421 SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE----PASSNKWQLDKWLNKVN 476
S +SSS S SSS + S+T K H E E + N ++++ +N+
Sbjct: 380 SPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGG 439
Query: 477 PHKPPILIQNESHGSESNQYYNPVKED 503
+ + + S SES+ +P+ +
Sbjct: 440 SRSRRVSLSDGS-DSESSSASSPLHHE 465
Score = 36.6 bits (83), Expect = 0.15
Identities = 58/242 (23%), Positives = 90/242 (37%), Gaps = 43/242 (17%)
Query: 223 KPSLVQQKPTAYVRPM-DGQDQ-APDESPKLKSSSETSVH----------CTSYRGVPAS 270
KP + KP + + + GQD+ AP + P + S E S S+ P
Sbjct: 257 KPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPL 316
Query: 271 KPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFP 330
+ K ++ S K G+ ET+ ++ + LPP I P
Sbjct: 317 ILTCSADKKQIKDKSHVKMGKVKIESETSE------KKKSTLPPFDDIVDPN-------- 362
Query: 331 FPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALR 390
DS + N K D+E SP + +S++S S + QQ R+ ++
Sbjct: 363 ----DSDVEE---NISSKSDSEQPSPASSSSSSSS-------SFTPSQTRQQGPLRSIMK 408
Query: 391 AL-SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSK 449
L SD + + S+ + GS S S GSDSE+ S+SS
Sbjct: 409 DLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSL--SDGSDSESSSASSPLHHEP 466
Query: 450 PP 451
PP
Sbjct: 467 PP 468
Score = 32.7 bits (73), Expect = 2.2
Identities = 64/272 (23%), Positives = 103/272 (37%), Gaps = 26/272 (9%)
Query: 666 IETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGS 725
I T SSSSSSSS S S S + + ++S+SS + +++ S P +
Sbjct: 146 IHTSSSSSSSSSSSSSSSSSSS---SSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKE 202
Query: 726 INARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE 785
+ + D ++E + F K E + L + +P+ +E
Sbjct: 203 HKEKPSKD-SREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEE------KIVPKMAFKE 255
Query: 786 PGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNED-DYREIKKSQGE---KDS 841
P +S DS + D A SKR D+E+ ++ KKS E K
Sbjct: 256 PKPMSKEPKPDSNLLTITSGQDKKA-----PSKRPPISDSEELSAKKRKKSSSEALFKSF 310
Query: 842 SSR----LATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDA--SKHKYTSED 895
SS L S + ++ + V I +EK +S + P D E+
Sbjct: 311 SSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKK-KSTLPPFDDIVDPNDSDVEEN 369
Query: 896 LTSSSRPNGNSLFTSASSSKKPKADSQLQPHG 927
++S S S +S+SSS SQ + G
Sbjct: 370 ISSKSDSEQPSPASSSSSSSSSFTPSQTRQQG 401
Score = 32.3 bits (72), Expect = 2.8
Identities = 41/191 (21%), Positives = 75/191 (39%), Gaps = 16/191 (8%)
Query: 818 KRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLR 877
+RK D R I S SSS ++S+S++ S++ + + +S + + +
Sbjct: 132 RRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSST 191
Query: 878 SPISPLSDASKHKY-----TSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTK 932
S P +HK + E ++ P+ + +S SSKKPK + L+
Sbjct: 192 SFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLK-------- 243
Query: 933 AAHNNSENIPLHKSRPQTKPWSPGSN--GHRDCKRQKLVFDDMPRSADYFMQEAKRMKHK 990
+ + +P +K P SN + +K P S + KR K
Sbjct: 244 -EEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSS 302
Query: 991 ADAMVEKFGKA 1001
++A+ + F A
Sbjct: 303 SEALFKSFSSA 313
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 65.1 bits (157), Expect = 4e-10
Identities = 180/990 (18%), Positives = 333/990 (33%), Gaps = 122/990 (12%)
Query: 74 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 133
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 134 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 193
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 194 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 253
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 254 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 305
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 306 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 364
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 365 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 415
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 416 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 473
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 474 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 526
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 527 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 583
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 584 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 639
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 640 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 699
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 700 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 758
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 759 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 818
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 819 RKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRS 878
+ K D+ E S GE ++ A I I ++ N RS
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSA-------------QVIKPPLIFVDPN----RS 967
Query: 879 PISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNS 938
P P + ++ + +S+ + ++A SS D + P LT N
Sbjct: 968 PAGPAATPAQAQ------AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 939 ENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKF 998
+P R K G++ ++ R + + K+ + A + +K
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSR---------------ISDGKKQEGPATQVSKKN 1066
Query: 999 GKALNYAEAALSFIECGNAMEQGPMESKSP 1028
+L +AAL + + Q P+ P
Sbjct: 1067 PASLPLTQAALKVLAQKASEAQPPVARTQP 1096
Score = 60.1 bits (144), Expect = 1e-08
Identities = 129/598 (21%), Positives = 204/598 (34%), Gaps = 115/598 (19%)
Query: 126 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 184
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 185 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 232
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 233 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 292
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 293 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 351
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 352 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 405
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 406 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 464
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 969
Query: 465 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 519
P P Q ++ SES + + + +D P +R
Sbjct: 970 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 520 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVSAAAPPPAV 567
+ PR A KA S G KQ+ P V + P ++
Sbjct: 1019 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV-----SKKNPASL 1070
Query: 568 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKT 627
P A + S + P RT+ +S D A+GT P+ T
Sbjct: 1071 PLTQAALKVLAQKASEAQPPVARTQPSSGVD-------------SAVGTLPATSPQSTSV 1117
Query: 628 RPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQ 685
+ G N+ LR E ++ + P+S + E +SS SSS S+ D E Q
Sbjct: 1118 QAKGTNK------LRKPKLPEVQQ----ATKAPESSDDSE-DSSDSSSGSEEDGEGPQ 1164
Score = 58.9 bits (141), Expect = 3e-08
Identities = 191/993 (19%), Positives = 335/993 (33%), Gaps = 151/993 (15%)
Query: 221 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 278
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 279 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 338
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 339 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 394
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 395 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 453
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 454 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 513
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 514 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 567
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 568 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 625
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 626 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 682
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 683 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 740
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Query: 741 QFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESA 800
+ +E S D E+ + L I + P S+PA + A
Sbjct: 544 DSES-----SSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKP-----TSSPAKGPPQKA 592
Query: 801 PPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNM 860
P AEK + S+ + + D E + + L + N
Sbjct: 593 GPV-AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA-CPKKTNT 650
Query: 861 NINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKAD 920
++ P+ + R + S A SS G + + SS ++D
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTATSPAG----------SSPAVAGGTQRPAEDSSSSEESD 700
Query: 921 SQLQPHGGDLT--------KAAHNNSENIPLHKSRPQ-TKPWSPGSNG------------ 959
S+ + G +T K + ++P+ S Q T P PG G
Sbjct: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
Query: 960 HRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFI-ECGNAM 1018
+ ++ ++ S K+ + KA+ + A A + A
Sbjct: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
Query: 1019 EQGPMESKSPYTMYSETVELIR-----------YAMRLKTHSGP---NATPEDKQLAALC 1064
++ P + K P + L R A + +GP + + E++ +
Sbjct: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
Query: 1065 YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNP 1124
LA ++K +A + K S + AP+P G +G S +
Sbjct: 881 AETLA-------QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Query: 1125 SPASSVGSQG----SLSNASALSPSTIVSIPQR 1153
S + S G ++++A + P I P R
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 966
Score = 40.4 bits (93), Expect = 0.010
Identities = 61/251 (24%), Positives = 96/251 (38%), Gaps = 40/251 (15%)
Query: 241 QDQAPDESPKLKSSSETSVHCTSYRGV--------PASKPE-PARAKAKLSKFSIPKQGE 291
QD + S + S E TS + + P P PA A+ S P++
Sbjct: 929 QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKAR 988
Query: 292 ES----RSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFP-----------FPNKDS 336
S RS + S E++I L P I+ PT P +K+S
Sbjct: 989 ASESTARSSSSESEDEDVIPATQCLTP--GIRTNVVTMPTAHPRIAPKASMAGASSSKES 1046
Query: 337 QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSA 396
+S G ++G A S N S + + LK+ + + Q RT + DSA
Sbjct: 1047 SRISDGKK--QEGPATQVSKKNPAS-LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSA 1103
Query: 397 VVQQP--NCRTSVPSSKGSSS---------SSSSGSSSSSSDSESSSGSDSETESSSSES 445
V P + +++ +KG++ ++ + SS DSE SS S S +E
Sbjct: 1104 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGP 1163
Query: 446 EGSKPPHFSSP 456
+G+K H P
Sbjct: 1164 QGAKSAHTLGP 1174
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 63.5 bits (153), Expect = 1e-09
Identities = 116/647 (17%), Positives = 225/647 (34%), Gaps = 78/647 (12%)
Query: 353 PESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKG 412
P S G + +K+ S+E+ + +++ + + ++ V +
Sbjct: 419 PFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT---EETQVTEEVTEEEE 475
Query: 413 SSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWL 472
+ G + E + G + ET+S +E +SPE E S K +
Sbjct: 476 KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEA-------ASPEKEAKSPVKEEAKSPA 528
Query: 473 NKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQR 532
+P K E E + +P KE+ + P+ P E + + K ++
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKAK--SPAKEEAK---SPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 533 PRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPAR-------RSAGK 585
++ K + KSP A + A P E A +PA +S K
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK 643
Query: 586 KPTRRTERTSAGDGANCHRPEE---PAAADALGTSVVVPPEPTKTRPCGNNRASHRKELR 642
+ + E+ + + PE+ P A+A P + + ++ ++E +
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 643 SSVTCE---KRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 699
S + K + + KE +T + S + E+ + P KA+T+
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-EKAKTL--- 759
Query: 700 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPF----------- 748
D + EA R+P + S + +E++ P
Sbjct: 760 -----DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEI 814
Query: 749 -GRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSD 807
+ E+ SP+K+ ++ + + VK P++ APAT +E S +
Sbjct: 815 PKKEEVKSPVKEEEKPQEVKVK-----------EPPKKAEEEKAPATPKTEEKKDSKKEE 863
Query: 808 TPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAI 867
P ++A PK K + K + + + K + +K+ + + A + + A
Sbjct: 864 APKKEA-PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEA-PAKVEVKEDAK 921
Query: 868 PINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHG 927
P K E + P D +K K S+ +A K K + +P
Sbjct: 922 PKEKTEVAKKEP-----DDAKAKEPSKPAEKKE---------AAPEKKDTKEEKAKKPEE 967
Query: 928 GDLTKA-AHNNSENIPLHKSRPQT-KPWSPGSNGHRDCKRQKLVFDD 972
T+A A + + + S+P+ K S +D K + +D
Sbjct: 968 KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 42.4 bits (98), Expect = 0.003
Identities = 90/465 (19%), Positives = 157/465 (33%), Gaps = 48/465 (10%)
Query: 178 RQQPRAKQVCNVEVGLQTQERPPAMA---AKHSSSGHCVQNFPPSLASKPSLVQQKPTAY 234
+ P AK E + + P A AK + P S + P
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 235 VRPMDGQDQAPDE--SPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 292
P+ + ++P E SP+ K+ S T S + + E A++ K +K + + +
Sbjct: 619 KSPVKEEAKSPAEVKSPE-KAKSPTKEEAKSPEKAKSPEKEEAKSPEK-AKSPVKAEAKS 676
Query: 293 SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVE---------PTKFPFPNKDSQLVSSGH 343
++ E E P ++P K + P K P K+
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA 736
Query: 344 NNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNC 403
+P K +A+ SP+ S D+K S E + + R+ + A
Sbjct: 737 KSPVKEEAK--SPEKAKSPEKAKTLDVK--SPEAKTPAKEEARSPADKFPEKA------- 785
Query: 404 RTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEG------SKPPHFSSPE 457
++ V S + S + E E +S E E +PP + E
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845
Query: 458 AEPASSNKWQLDKWLNKVNPHK--PPILIQNESHGSESNQYYNPV---KEDVQDCGKVPD 512
PA+ + + P K P ++ + + + V KE+ +D KVP
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905
Query: 513 VCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAV--------SAAAPP 564
+ + + E+K K +++ A K P K+ S PA A A P
Sbjct: 906 PEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKP 965
Query: 565 PAVPC--APAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEE 607
P A A+ + K + E++S+ D + PE+
Sbjct: 966 EEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 62.8 bits (151), Expect = 2e-09
Identities = 135/626 (21%), Positives = 214/626 (34%), Gaps = 118/626 (18%)
Query: 126 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 184
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 185 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 232
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 678
Query: 233 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 292
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 679 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 735
Query: 293 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 351
+ + + ++ P S + A G P P K + P++
Sbjct: 736 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 789
Query: 352 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 405
D+G+S SD EE + AQ +RA A
Sbjct: 790 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 835
Query: 406 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 464
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 836 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 892
Query: 465 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 519
P P Q ++ SES + + + +D P +R
Sbjct: 893 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 941
Query: 520 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVSAAAPPPAV 567
+ PR A KA S G KQ+ P V + P ++
Sbjct: 942 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV-----SKKNPASL 993
Query: 568 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKT 627
P A + S + P RT+ +S D A+GT P+ T
Sbjct: 994 PLTQAALKVLAQKASEAQPPVARTQPSSGVD-------------SAVGTLPATSPQSTSV 1040
Query: 628 RPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEE 687
+ G N+ LR E ++ + P+S + E +SS SSS S+ D E Q
Sbjct: 1041 QAKGTNK------LRKPKLPEVQQ----ATKAPESSDDSE-DSSDSSSGSEEDGEGPQ-- 1087
Query: 688 YPLSKAQTVAASASSGNDQRLKEAAA 713
A T+ S + ++E AA
Sbjct: 1088 -GAKSAHTLVGPTPSRTETLVEETAA 1112
Score = 59.7 bits (143), Expect = 2e-08
Identities = 157/788 (19%), Positives = 276/788 (35%), Gaps = 108/788 (13%)
Query: 268 PASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPT 327
P K PA AKA+ K + E+S+S S EE +AP + +P+
Sbjct: 313 PPGKTGPAVAKAQAGK-----REEDSQSSSEESDSEE--------------EAPAQAKPS 353
Query: 328 -KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSML----EDDLKLSSDEEENEQQ 382
K P S + +P+KG A G + + E+D + SS+E +++++
Sbjct: 354 GKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 410
Query: 383 AA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS---SSSSGSSSSSSDSESSSGSDS 436
A ++ L S V+ + P KG+ ++ S+ + S+S
Sbjct: 411 ALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSES 470
Query: 437 ETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN--KVNPHKP-PILIQNESHGSES 493
+E SS S+G P + P E + N Q + K P K P+ +Q ++
Sbjct: 471 SSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMD 529
Query: 494 NQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQK 548
N + D D + P +P+L+ + K+ K+ +A AP G +
Sbjct: 530 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA- 588
Query: 549 SPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSAGKKPTRRT----ERTSAGDGAN 601
P A S A PAV PAE++ + + ++ T + S G G
Sbjct: 589 --PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ 646
Query: 602 CHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 661
P +LG P P KT P + ++E S E +
Sbjct: 647 VKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQV 704
Query: 662 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRA 721
+T++ ++ +++ + P K T AA A + ++K N +
Sbjct: 705 KTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763
Query: 722 PVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE 780
G + + +A + Q G +E S ++ E TL P
Sbjct: 764 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE----------TLAQVKPS 813
Query: 781 HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD 840
+ APA + +P + TP K P + + K D+ E S GE
Sbjct: 814 GKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAP 869
Query: 841 SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS 900
++ A I I ++ N RSP P + ++ + +S+
Sbjct: 870 AAVTSA-------------QVIKPPLIFVDPN----RSPAGPAATPAQAQ------AAST 906
Query: 901 RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH 960
+ ++A SS D + P LT N +P R K G++
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSS 966
Query: 961 RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ 1020
++ R + + K+ + A + +K +L +AAL + + Q
Sbjct: 967 KESSR---------------ISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQ 1011
Query: 1021 GPMESKSP 1028
P+ P
Sbjct: 1012 PPVARTQP 1019
Score = 55.1 bits (131), Expect = 4e-07
Identities = 165/828 (19%), Positives = 286/828 (34%), Gaps = 138/828 (16%)
Query: 221 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 278
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 279 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 338
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 339 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTA-LRALS 393
VS P G A +P G +++S +D SSDE + E +A+++ +RA S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEVKASEKILQVRAAS 227
Query: 394 DSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSS--GSDSETES----------- 440
A T P K + +S + + DSESSS SDSE E+
Sbjct: 228 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKA 287
Query: 441 --SSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN 498
+S+ + P SP A + + + K K Q+ S S+S +
Sbjct: 288 SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--- 344
Query: 499 PVKEDVQDCGKVPDV-----------------------------CQPSLREKEIKSTCKE 529
+ GK P V Q +E++ +S+ +E
Sbjct: 345 EAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404
Query: 530 EQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPP---PAVPCAPAENAPAPARRSAGK- 585
R A A + VK V A + P A P P + PA GK
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 586 KPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSV 645
+ + + D ++ P A A ++ +PT + G + + + V
Sbjct: 465 EEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA--GPVAVQV 522
Query: 646 TCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGND 705
EK + S+ E+ S+ S + + + + Q + L QT A +
Sbjct: 523 KAEKP--------MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 574
Query: 706 QRLKEAAAN-GGSGPR------APVGSINA-----------RTTSDIAKELEEQFYTLVP 747
K A G PR +P GS A ++S+ + EE+ V
Sbjct: 575 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 634
Query: 748 FGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE--PGVLSAPATKDSESAPPSHT 805
G+ + + ++++ V + +L LP + P V A K +S
Sbjct: 635 VGQAKSVG---KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE 691
Query: 806 SDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSV 865
SD+ A P + +KK+Q + + ++ A S T+SA + +
Sbjct: 692 SDSEEAAASPAQVK----------TSVKKTQAKANPAAARAPSAKGTISAP--GKVVTAA 739
Query: 866 AIPINKNEKMLRSPI-----------SPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSS 914
A ++ ++ P+ P S S K + + + P +S + S
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799
Query: 915 KKPKAD--SQLQPHGGDLTKAAHNNSENIPLHKS-RPQTKPWSPGSNG 959
+ +A+ +Q++P G K + P +S R P PG G
Sbjct: 800 SEEEAETLAQVKPSG----KTHQIRAALAPAKESPRKGAAPTPPGKTG 843
Score = 40.8 bits (94), Expect = 0.008
Identities = 76/348 (21%), Positives = 121/348 (34%), Gaps = 42/348 (12%)
Query: 381 QQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSS----------------SSSGSSSS 424
QQ ++ R + A +Q R S P S SS +S+ SS
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
Query: 425 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILI 484
+D SS ++ E+ + G+ PH PA+ + L+ +P K
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPH-------PATGKT--VANLLSGKSPRKSAEPS 164
Query: 485 QNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKG 544
N + SE+ + + V G S + + S T + S+
Sbjct: 165 ANTTLVSETEE-----EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEK 219
Query: 545 VKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHR 604
+ Q +A A PA P A A A ++ KP +E S+ + ++
Sbjct: 220 ILQVRAASAPAKGTPGKGATPA----PPGKAGAVASQTKAGKPEEDSE--SSSEESSDSE 273
Query: 605 PEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKE 664
E PAA L KT G A ++ R G + +
Sbjct: 274 EETPAAKALLQAKA-----SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAG 327
Query: 665 FIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA 712
E +S SSS SDS+ E+ + P KA V A+++ + K AA
Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 375
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 61.2 bits (147), Expect = 6e-09
Identities = 75/278 (26%), Positives = 107/278 (38%), Gaps = 20/278 (7%)
Query: 335 DSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLS---SDEEENEQQAAQRTALRA 391
DS+ + + + D E + D + D K SD E+ E ++ + +L A
Sbjct: 962 DSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYA 1021
Query: 392 LSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP 451
SD + +S SS SSSSSSS SSSSSS SESSS + E E ++ S PP
Sbjct: 1022 DSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPP 1081
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVP 511
P PA ++ P+ E S + P +E P
Sbjct: 1082 R-EVPVPTPAPVEVPVPERVAGS------PVTPLPEQEASPARP-AGPTEESPPSAPLRP 1133
Query: 512 DVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAP 571
P + ++RP + ++K+ + V A PPPA P P
Sbjct: 1134 ----PEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATP--P 1187
Query: 572 AENAPAPARRSAGKKPTRRTERTSAGDGANCHR--PEE 607
P PA R A + RT R D A+ + PEE
Sbjct: 1188 QAKFPGPASRKA-PRGVERTIRNLPLDHASLVKSWPEE 1224
Score = 39.7 bits (91), Expect = 0.018
Identities = 46/169 (27%), Positives = 65/169 (38%), Gaps = 27/169 (15%)
Query: 316 SAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKK-GDAEPES----PDNGTSNTSMLEDDL 370
+A+ PG P ++D+ SS + P G P+S P +T +D
Sbjct: 232 TAVGTPGNGTPC-----SQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSA 286
Query: 371 KLSSD---------EEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGS 421
SS E + Q A R A S S T+ ++ S+SSSS S
Sbjct: 287 YSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSS 346
Query: 422 SSSSSDSESSSGSDSETESSSSESEG--------SKPPHFSSPEAEPAS 462
SSSSS S SSS S + + E S PP ++ E P +
Sbjct: 347 SSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGA 395
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 60.5 bits (145), Expect = 1e-08
Identities = 148/800 (18%), Positives = 271/800 (33%), Gaps = 84/800 (10%)
Query: 74 GNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTP 133
G D + + S+++ + G P Q + + +A P + T
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP--- 250
Query: 134 AAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGL 193
Q K G + K P + + + + G Q ++++ V
Sbjct: 251 ------QVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
Query: 194 QTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKS 253
+ P A + G + A KP + ++ D +++ P L++
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPE--EDSESSSEESSDSEEETPAAKALLQA 362
Query: 254 SSETSVHCTSYRGVPASKPE--------PARAKAKLSKFSIPKQGEESRSGETNSCVEEI 305
+ PA + P + ++K K+ E+S+S S EE
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE- 421
Query: 306 IREMTWLPPLSAIQAPGKVEPT-KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTS 364
+AP + +P+ K P S + +P+KG A G +
Sbjct: 422 -------------EAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 365 ML----EDDLKLSSDEEENEQQAA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS-- 415
+ E+D + SS+E +++++A ++ L S V+ + P KG+
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 416 -SSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN- 473
++ S+ + S+S +E SS S+G P + P E + N Q +
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSP 584
Query: 474 -KVNPHKP-PILIQNESHGSESNQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKST 526
K P K P+ +Q ++ N + D D + P +P+L+ + K+
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
Query: 527 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSA 583
K+ +A AP G + P A S A PAV PAE++ + +
Sbjct: 645 PKKTNTTASAKVAPVRVGTQA---PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
Query: 584 GKKPTRRT----ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 639
++ T + S G G P +LG P P KT P + ++
Sbjct: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQ 759
Query: 640 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 699
E S E + +T++ ++ +++ + P K T AA
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQ 818
Query: 700 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLK 758
A + ++K N + G + + +A + Q G +E S +
Sbjct: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 759 DSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSK 818
+ E TL P + APA + +P + TP K P +
Sbjct: 879 EEAE----------TLAQVKPSGKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAA 924
Query: 819 RKRKCDNEDDYREIKKSQGE 838
+ K D+ E S GE
Sbjct: 925 QAGKQDDSGSSSEESDSDGE 944
Score = 57.0 bits (136), Expect = 1e-07
Identities = 113/540 (20%), Positives = 192/540 (35%), Gaps = 81/540 (15%)
Query: 221 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 278
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 279 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 338
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 339 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSD 394
VS P G A +P G +++S +D SSDE + E + + + A S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEGKPSVKPAQVKASS 227
Query: 395 SAVVQQPNCRTS-VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHF 453
+ + P + + P G + G + + +SE+ SESE
Sbjct: 228 VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE------- 280
Query: 454 SSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDV 513
E PA + ++V + + ++ S ++ G V
Sbjct: 281 ---EEAPAGTR--------SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 514 CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP------AV 567
+ E++ +S+ E+ + + P +K + Q + +A+AP A
Sbjct: 330 TKAGKPEEDSESS--SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 568 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTS--VVVPPEPT 625
P P + PA A+ AGK R E + + + E PA A G + V P
Sbjct: 388 PAPPGKTGPAVAKAQAGK----REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 626 KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE--- 682
K P + + R+T + V K+ E +S SSS SDSD E
Sbjct: 444 KESP-----------RKGAAPAPPRKTGPAAAQVQVGKQ--EEDSRSSSEESDSDREALA 490
Query: 683 --SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEE 740
+ + PL K+ V +++ G K G+GP P G + T S + EE
Sbjct: 491 AMNAAQVKPLGKSPQVKPASTMGMGPLGK------GAGP-VPPGKVGPATPSAQVGKWEE 543
Score = 45.4 bits (106), Expect = 3e-04
Identities = 95/441 (21%), Positives = 166/441 (37%), Gaps = 43/441 (9%)
Query: 267 VPASKPEPARAKAKLSKF-----SIPKQGEESRSGETNSCV----EEIIREMTWLPPLSA 317
VP K PA A++ K+ S ++ +S GE + V E+ + + P S+
Sbjct: 524 VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS 583
Query: 318 IQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK--LSSD 375
P K P K P +N + + +S D+ + +M K L
Sbjct: 584 ---PAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP 639
Query: 376 EEENEQQAAQRTALRALSDSAV-VQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGS 434
+ + + TA ++ V Q P + S GSS + + G+ + DS SS S
Sbjct: 640 QTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES 699
Query: 435 DSETESSS-SESEGSKPPHFSSPEAEPAS-SNKWQLDKWLNKVNPHKP-PILIQNESHGS 491
DSE E + + + G + + AS K L + V P K P + Q ++
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ 759
Query: 492 ESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPP 551
E ++ + + D ++ P + S+++ + K+ A +AP +KG
Sbjct: 760 EDSE-SSEEESDSEEAAASPAQVKTSVKKTQAKAN-------PAAARAPSAKGTISAPGK 811
Query: 552 AAVAVAVSAAAPPPAV--PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPA 609
A A + P V P +N+ AR A + T+A A E+
Sbjct: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA--QAQTGPEEDSG 869
Query: 610 AADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSK------ 663
+++ S + +P G ++R+++ K R + P K
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTH-----QIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 664 -EFIETESSSSSSSSDSDLES 683
+ +S SSS SDSD E+
Sbjct: 925 QAGKQDDSGSSSEESDSDGEA 945
Score = 39.7 bits (91), Expect = 0.018
Identities = 71/341 (20%), Positives = 119/341 (34%), Gaps = 51/341 (14%)
Query: 126 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 184
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 185 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 232
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 755
Query: 233 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 292
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 756 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 812
Query: 293 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 351
+ + + ++ P S + A G P P K + P++
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 866
Query: 352 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 405
D+G+S SD EE + AQ +RA A
Sbjct: 867 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 406 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESE 446
P K S++ +G S S S SD E ++ + ++
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 60.1 bits (144), Expect = 1e-08
Identities = 129/598 (21%), Positives = 204/598 (34%), Gaps = 115/598 (19%)
Query: 126 CSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAK- 184
C T+T A+ V + GT +KAG S G + D ++ ++
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 185 ----------QVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASK--PSLVQQKPT 232
Q +V GLQ + AA G Q P L K P++ Q K
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVK------AASVPVKGSLGQGTAPVLPGKTGPTVTQVK-- 678
Query: 233 AYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEE 292
+ + + +ES ++++ + TS + A K PA A+A +K +I G+
Sbjct: 679 --AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQA-KANPAAARAPSAKGTISAPGKV 735
Query: 293 -SRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDA 351
+ + + ++ P S + A G P P K + P++
Sbjct: 736 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARG---PASVPSVGKAVATAAQAQTGPEE--- 789
Query: 352 EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ------RTALRALSDSAVVQQPNCRT 405
D+G+S SD EE + AQ +RA A
Sbjct: 790 -----DSGSSEEE---------SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 835
Query: 406 SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP-HFSSPEAEPASSN 464
P K S++ +G S S S SD E ++ + ++ KPP F P PA
Sbjct: 836 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA--- 892
Query: 465 KWQLDKWLNKVNPHKPPILIQ-----NESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLR 519
P P Q ++ SES + + + +D P +R
Sbjct: 893 -----------GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 941
Query: 520 EKEIKSTCKEEQRPRTANKAPG------------SKGVKQKSPPAAVAVAVSAAAPPPAV 567
+ PR A KA S G KQ+ P V + P ++
Sbjct: 942 TNVV---TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV-----SKKNPASL 993
Query: 568 PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKT 627
P A + S + P RT+ +S D A+GT P+ T
Sbjct: 994 PLTQAALKVLAQKASEAQPPVARTQPSSGVD-------------SAVGTLPATSPQSTSV 1040
Query: 628 RPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQ 685
+ G N+ LR E ++ + P+S + E +SS SSS S+ D E Q
Sbjct: 1041 QAKGTNK------LRKPKLPEVQQ----ATKAPESSDDSE-DSSDSSSGSEEDGEGPQ 1087
Score = 59.7 bits (143), Expect = 2e-08
Identities = 157/788 (19%), Positives = 276/788 (35%), Gaps = 108/788 (13%)
Query: 268 PASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPT 327
P K PA AKA+ K + E+S+S S EE +AP + +P+
Sbjct: 313 PPGKTGPAVAKAQAGK-----REEDSQSSSEESDSEE--------------EAPAQAKPS 353
Query: 328 -KFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSML----EDDLKLSSDEEENEQQ 382
K P S + +P+KG A G + + E+D + SS+E +++++
Sbjct: 354 GKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE 410
Query: 383 AA---QRTALRALSDSAVVQQPNCRTSVPSSKGSSS---SSSSGSSSSSSDSESSSGSDS 436
A ++ L S V+ + P KG+ ++ S+ + S+S
Sbjct: 411 ALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSES 470
Query: 437 ETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN--KVNPHKP-PILIQNESHGSES 493
+E SS S+G P + P E + N Q + K P K P+ +Q ++
Sbjct: 471 SSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMD 529
Query: 494 NQYYNPVKEDVQDCGKVPDV-----CQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQK 548
N + D D + P +P+L+ + K+ K+ +A AP G +
Sbjct: 530 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQA- 588
Query: 549 SPPAAVAVAVSAAAPPPAVPCA---PAENAPAPARRSAGKKPTRRT----ERTSAGDGAN 601
P A S A PAV PAE++ + + ++ T + S G G
Sbjct: 589 --PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ 646
Query: 602 CHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 661
P +LG P P KT P + ++E S E +
Sbjct: 647 VKAASVPVKG-SLGQGTA-PVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQV 704
Query: 662 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRA 721
+T++ ++ +++ + P K T AA A + ++K N +
Sbjct: 705 KTSVKKTQAKANPAAARAPSAKGTISAP-GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763
Query: 722 PVGSINARTTSD-IAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE 780
G + + +A + Q G +E S ++ E TL P
Sbjct: 764 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE----------TLAQVKPS 813
Query: 781 HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD 840
+ APA + +P + TP K P + + K D+ E S GE
Sbjct: 814 GKTHQIRAALAPA----KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAP 869
Query: 841 SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS 900
++ A I I ++ N RSP P + ++ + +S+
Sbjct: 870 AAVTSA-------------QVIKPPLIFVDPN----RSPAGPAATPAQAQ------AAST 906
Query: 901 RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH 960
+ ++A SS D + P LT N +P R K G++
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSS 966
Query: 961 RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ 1020
++ R + + K+ + A + +K +L +AAL + + Q
Sbjct: 967 KESSR---------------ISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQ 1011
Query: 1021 GPMESKSP 1028
P+ P
Sbjct: 1012 PPVARTQP 1019
Score = 55.1 bits (131), Expect = 4e-07
Identities = 165/828 (19%), Positives = 286/828 (34%), Gaps = 138/828 (16%)
Query: 221 ASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRG--VPASKPEPARAK 278
A + + +Q K T P+ + + +E +++ + S + A P + K
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEK 124
Query: 279 AKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQL 338
AK K G T V ++ GK P K P+ ++ L
Sbjct: 125 AKAETEKAGKTGNSMPHPATGKTVANLLS--------------GK-SPRKSAEPSANTTL 169
Query: 339 VSSGHNN---PKKGDA-EPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTA-LRALS 393
VS P G A +P G +++S +D SSDE + E +A+++ +RA S
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSS--SEDTSSSSDETDVEVKASEKILQVRAAS 227
Query: 394 DSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSS--GSDSETES----------- 440
A T P K + +S + + DSESSS SDSE E+
Sbjct: 228 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKA 287
Query: 441 --SSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYN 498
+S+ + P SP A + + + K K Q+ S S+S +
Sbjct: 288 SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--- 344
Query: 499 PVKEDVQDCGKVPDV-----------------------------CQPSLREKEIKSTCKE 529
+ GK P V Q +E++ +S+ +E
Sbjct: 345 EAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404
Query: 530 EQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPP---PAVPCAPAENAPAPARRSAGK- 585
R A A + VK V A + P A P P + PA GK
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 586 KPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSV 645
+ + + D ++ P A A ++ +PT + G + + + V
Sbjct: 465 EEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA--GPVAVQV 522
Query: 646 TCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGND 705
EK + S+ E+ S+ S + + + + Q + L QT A +
Sbjct: 523 KAEKP--------MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 574
Query: 706 QRLKEAAAN-GGSGPR------APVGSINA-----------RTTSDIAKELEEQFYTLVP 747
K A G PR +P GS A ++S+ + EE+ V
Sbjct: 575 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 634
Query: 748 FGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQE--PGVLSAPATKDSESAPPSHT 805
G+ + + ++++ V + +L LP + P V A K +S
Sbjct: 635 VGQAKSVG---KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE 691
Query: 806 SDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSV 865
SD+ A P + +KK+Q + + ++ A S T+SA + +
Sbjct: 692 SDSEEAAASPAQVK----------TSVKKTQAKANPAAARAPSAKGTISAP--GKVVTAA 739
Query: 866 AIPINKNEKMLRSPI-----------SPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSS 914
A ++ ++ P+ P S S K + + + P +S + S
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799
Query: 915 KKPKAD--SQLQPHGGDLTKAAHNNSENIPLHKS-RPQTKPWSPGSNG 959
+ +A+ +Q++P G K + P +S R P PG G
Sbjct: 800 SEEEAETLAQVKPSG----KTHQIRAALAPAKESPRKGAAPTPPGKTG 843
Score = 40.8 bits (94), Expect = 0.008
Identities = 76/348 (21%), Positives = 121/348 (34%), Gaps = 42/348 (12%)
Query: 381 QQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSS----------------SSSGSSSS 424
QQ ++ R + A +Q R S P S SS +S+ SS
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
Query: 425 SSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILI 484
+D SS ++ E+ + G+ PH PA+ + L+ +P K
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPH-------PATGKT--VANLLSGKSPRKSAEPS 164
Query: 485 QNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKG 544
N + SE+ + + V G S + + S T + S+
Sbjct: 165 ANTTLVSETEE-----EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEK 219
Query: 545 VKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHR 604
+ Q +A A PA P A A A ++ KP +E S+ + ++
Sbjct: 220 ILQVRAASAPAKGTPGKGATPA----PPGKAGAVASQTKAGKPEEDSE--SSSEESSDSE 273
Query: 605 PEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKE 664
E PAA L KT G A ++ R G + +
Sbjct: 274 EETPAAKALLQAKA-----SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA-VAKAQAG 327
Query: 665 FIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAA 712
E +S SSS SDS+ E+ + P KA V A+++ + K AA
Sbjct: 328 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 375
Score = 40.4 bits (93), Expect = 0.010
Identities = 61/251 (24%), Positives = 96/251 (38%), Gaps = 40/251 (15%)
Query: 241 QDQAPDESPKLKSSSETSVHCTSYRGV--------PASKPE-PARAKAKLSKFSIPKQGE 291
QD + S + S E TS + + P P PA A+ S P++
Sbjct: 852 QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKAR 911
Query: 292 ES----RSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFP-----------FPNKDS 336
S RS + S E++I L P I+ PT P +K+S
Sbjct: 912 ASESTARSSSSESEDEDVIPATQCLTP--GIRTNVVTMPTAHPRIAPKASMAGASSSKES 969
Query: 337 QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSA 396
+S G ++G A S N S + + LK+ + + Q RT + DSA
Sbjct: 970 SRISDGKK--QEGPATQVSKKNPAS-LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSA 1026
Query: 397 VVQQP--NCRTSVPSSKGSSS---------SSSSGSSSSSSDSESSSGSDSETESSSSES 445
V P + +++ +KG++ ++ + SS DSE SS S S +E
Sbjct: 1027 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGP 1086
Query: 446 EGSKPPHFSSP 456
+G+K H P
Sbjct: 1087 QGAKSAHTLGP 1097
>gi|169166609 PREDICTED: similar to ribonucleic acid binding protein
S1 isoform 6 [Homo sapiens]
Length = 305
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 566
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 567 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|113415994 PREDICTED: similar to ribonucleic acid binding protein
S1 isoform 2 [Homo sapiens]
Length = 305
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 566
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 567 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|113415504 PREDICTED: similar to ribonucleic acid binding protein
S1 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 566
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 567 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|169166499 PREDICTED: similar to ribonucleic acid binding protein
S1 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 566
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 567 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|113415498 PREDICTED: similar to ribonucleic acid binding protein
S1 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 566
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 567 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|88973230 PREDICTED: similar to ribonucleic acid binding protein
S1 isoform 3 [Homo sapiens]
Length = 305
Score = 58.9 bits (141), Expect = 3e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRH 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPA 566
+ + P R S C E + P A KA Q A V A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYACVEFENPDEAEKALKHMDGGQIDGQEITATVVLAPWPRPT 246
Query: 567 ----------VPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWLRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRHSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 58.9 bits (141), Expect = 3e-08
Identities = 67/236 (28%), Positives = 102/236 (43%), Gaps = 36/236 (15%)
Query: 332 PNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRA 391
P K+ + SS ++ + S + +S+ S SSD E + AL+
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSS-------SSDSEGSSLPVQPEVALKR 2578
Query: 392 LSDSAVVQQPNCRTSVP-------------SSKGSSSSSSSGSSSSSSDSESSSGSDSET 438
+ + R P SS SSSSSSS SSSSSS S SSS S S +
Sbjct: 2579 VPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2638
Query: 439 ESSSSESEGSKPPHFSSPEA--EPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQY 496
SSSS S S P P+A +PAS K + ++ +P KP +S +
Sbjct: 2639 SSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSR-SPRKP-----IDSLRDSRSLS 2692
Query: 497 YNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQR-PRTANKAPGSKGVKQKSPP 551
Y+PV+ + P QPS R+++ S+ + +R R +++P K ++ P
Sbjct: 2693 YSPVER------RRPSP-QPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSP 2741
Score = 58.5 bits (140), Expect = 4e-08
Identities = 118/497 (23%), Positives = 187/497 (37%), Gaps = 81/497 (16%)
Query: 198 RPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSET 257
R PA A S +G PP+ A+ PS + + G A +P + S T
Sbjct: 2301 RTPAALAALSLTG---SGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRT 2357
Query: 258 SVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSA 317
+ + + +++ PA + A L+ +P E SG T+ + + R T PP +
Sbjct: 2358 AA-ALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRT--PPSAP 2414
Query: 318 IQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT---------SNTSMLED 368
Q+ ++ + P P+ S P D +P SP + T+ +
Sbjct: 2415 SQS--RMTSERAPSPSSRMGQAPSQSLLPPAQD-QPRSPVPSAFSDQSRCLIAQTTPVAG 2471
Query: 369 DLKLSSDE-EENEQQAAQRTALRALSDSAV-------------VQQPNCRTSVPSSKGSS 414
LSS A + ++ V QQP+ ++ +K
Sbjct: 2472 SQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERR 2531
Query: 415 SSSSSGSSSSSSDSESSSGSDSETE-SSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 473
SSSSS SSSSSS S SSS S S + SSSS+SEGS P PE L
Sbjct: 2532 SSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP--VQPEVA------------LK 2577
Query: 474 KVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRP 533
+V P KE V++ G+ P+ P+ R++ S+
Sbjct: 2578 RVPSPTP------------------APKEAVRE-GRPPEP-TPAKRKRRSSSSSSSSSSS 2617
Query: 534 RTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTER 593
+++ + S S ++ + + S+++ P +PA+ P + A K ER
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP----SPAKPGPQALPKPASPKKPPPGER 2673
Query: 594 TSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTR 653
S P +P D+L S + P + R + ++ SS +R R
Sbjct: 2674 RS-------RSPRKP--IDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQR 2724
Query: 654 GLSRIVPKSKEFIETES 670
G SR P K ET S
Sbjct: 2725 GDSR-SPSHKRRRETPS 2740
Score = 56.6 bits (135), Expect = 1e-07
Identities = 163/798 (20%), Positives = 275/798 (34%), Gaps = 93/798 (11%)
Query: 216 FPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPA--SKPE 273
F L + PSL ++ + + +PD K SS S+ VP S+
Sbjct: 1359 FLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRER 1418
Query: 274 PARAKAKLSKFSIPKQ-GEESRSGETNSCVEEIIREMTWLPPLSAIQ--APGKVEPTKFP 330
+ A + K +P+ SRSG + +R+ + P ++ +PG + + P
Sbjct: 1419 SSSASSPEMKDGLPRTPSRRSRSGSSPG-----LRDGSGTPSRHSLSGSSPGMKDIPRTP 1473
Query: 331 FPNKDSQLVSSGHNN--PKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTA 388
+ S+ SS P+ SP + N L + S E +Q+ RT
Sbjct: 1474 SRGR-SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTP 1532
Query: 389 L----------------------RALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 426
L R+ SDS+ + RT + S SS S S S
Sbjct: 1533 LGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLS 1592
Query: 427 DSESSSGSDSETES-------SSSESEGSKPPHFSSPEAEPASSNKWQLDKW-------- 471
S SGS E + + S S+ S P +P A P S K
Sbjct: 1593 PRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGS 1652
Query: 472 -LNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEE 530
+ +P PP + GS S+ + + + P + S E+ +
Sbjct: 1653 SSTESSPEHPP-KSRTARRGSRSS-------PEPKTKSRTPPRRRSSRSSPELTRKARLS 1704
Query: 531 QRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRR 590
+R R+A+ +P + + ++PP +P + P PAE + + RR + P R
Sbjct: 1705 RRSRSASSSPET---RSRTPPR------HRRSPSVSSP-EPAEKSRSSRRRRSASSP--R 1752
Query: 591 TERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKE---LRSSVTC 647
T+ TS + +P + + + R + S R++ RS VT
Sbjct: 1753 TKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTR 1812
Query: 648 EKRRTRGLSRIVPKSKEFIETES------SSSSSSSDSDLESEQEEYPLSKAQTVAASAS 701
+R G P +E T S S + +S S P ++++ A+ A+
Sbjct: 1813 RRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPAT 1872
Query: 702 SGNDQRLKEAAANGGSGPR-APVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDS 760
+ + S R +PV +R+ + + + + V R+ +P
Sbjct: 1873 HRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTR 1932
Query: 761 DEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPAT-KDSESAPPSHTSDTPAEKALPKSKR 819
RS SR P + + P T + S S T + P ++R
Sbjct: 1933 RRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRR 1992
Query: 820 KRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSP 879
+ + R +S+ + R S S T A + +P ++ RSP
Sbjct: 1993 RSRSRTSPVTRRRSRSRTSPVTRRR---SRSRTPPAIRRRSRSRTPLLPRKRSRS--RSP 2047
Query: 880 IS-PLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQP----HGGDLTKAA 934
++ S+ T+ S +R SAS S ++ S P H G T
Sbjct: 2048 LAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPV 2107
Query: 935 HNNSENIPLHKSRPQTKP 952
NS + SRP P
Sbjct: 2108 ALNSSRMSCF-SRPSMSP 2124
Score = 48.5 bits (114), Expect = 4e-05
Identities = 139/754 (18%), Positives = 245/754 (32%), Gaps = 74/754 (9%)
Query: 205 KHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSY 264
K G ++ P K S ++K + + ++P +PK K S+ S
Sbjct: 192 KKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSP--TPKSKRKSKDKKRKRSR 249
Query: 265 RGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKV 324
PA K A S + SRS ++ + T L S A G+
Sbjct: 250 STTPAPKSRRAHRSTSADSAS---SSDTSRSRSRSAAAKT---HTTALAGRSPSPASGRR 303
Query: 325 EPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAA 384
PF + P SP+ T S +D D+++ E+ A
Sbjct: 304 GEGDAPFSEPGTTSTQ-----------RPSSPETATKQPSSPYED----KDKDKKEKSAT 348
Query: 385 QRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSE 444
+ + S + +P T + + + S ++ S + + S T S
Sbjct: 349 RPSPSPERSSTG--PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPP 406
Query: 445 SEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSES------NQYYN 498
K P SS E+ P S ++ + + +P P SH S N+ +
Sbjct: 407 KSPEKLPQSSSSESSPPSPQPTKVSRHASS-SPESPKPAPAPGSHREISSSPTSKNRSHG 465
Query: 499 PVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAV 558
K D PS R +S + R R+ ++ P +G + P
Sbjct: 466 RAKRDKSHSHT------PSRRMGRSRSPATAK-RGRSRSRTPTKRGHSRSRSPQWRR--- 515
Query: 559 SAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSV 618
S +A +P + + + G +R T+R A R + A
Sbjct: 516 SRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPA------- 568
Query: 619 VVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSD 678
TR +R R+ S T +RR+R + +S+ S S +
Sbjct: 569 --------TRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTP 620
Query: 679 SDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKEL 738
+ S P+ + + A R + A G S R P +R+ + +
Sbjct: 621 ARRRSRTRS-PVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSG 679
Query: 739 EEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSE 798
+ T GR+ +P + RSL + R PQ G + + + ++
Sbjct: 680 RSRSRTPARRGRSRSRTPRRGRSRSRSLVRR------GRSHSRTPQRRGRSGSSSERKNK 733
Query: 799 SAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHC 858
S S + + + KS+ + R S + SRL+ S + ++ C
Sbjct: 734 SRTSQRRSRSNSSPEMKKSRISSR-------RSRSLSSPRSKAKSRLSLRRSLS-GSSPC 785
Query: 859 NMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPK 918
+ P ++ P + + +S + S + +SSS PK
Sbjct: 786 PKQKSQT--PPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK 843
Query: 919 ADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKP 952
S P G +T N P +S ++ P
Sbjct: 844 VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSP 877
Score = 48.1 bits (113), Expect = 5e-05
Identities = 129/648 (19%), Positives = 226/648 (34%), Gaps = 96/648 (14%)
Query: 409 SSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQL 468
S+ GSSS S ++ ++ + S S + +SS S FS P P ++ +
Sbjct: 2079 SASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMS------CFSRPSMSPTPLDRCRS 2132
Query: 469 DKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCK 528
L + + P+ + ++ GS + + + + VP+ S + +
Sbjct: 2133 PGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRT--SVPENHAQSRIALALTAISL 2190
Query: 529 EEQRPRTANKAPGSKGVKQKSP--------------------PAAVAVAVS-AAAPPPAV 567
RP + A G + P PAA A A++ A+A PA+
Sbjct: 2191 GTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAI 2250
Query: 568 P------------CAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADAL- 614
P A A N +P A RT N PAA AL
Sbjct: 2251 PTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALS 2310
Query: 615 ----GTSVVVPPEPTKTR----PCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFI 666
GT P+ +R P N R ++ +R + + P S
Sbjct: 2311 LTGSGTPPTAANYPSSSRTPQAPASANLVGPR-SAHATAPVNIAGSRTAAALAPASL--- 2366
Query: 667 ETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGS- 725
T + + + S ++L S + PLS + V+ S R A + P AP S
Sbjct: 2367 -TSARMAPALSGANLTSPR--VPLSAYERVSGRTSPPLLDR-----ARSRTPPSAPSQSR 2418
Query: 726 -INARTTSDIAKELEEQFYTLVPFGRNELLSPLKD--SDEIRSLWVK---------IDLT 773
+ R S ++ + +L+P +++ SP+ SD+ R L + +
Sbjct: 2419 MTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSG 2478
Query: 774 LLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIK 833
++ G+LS PA P S + PA + + R
Sbjct: 2479 AVATTTSSAGDHNGMLSVPA----PGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSS 2534
Query: 834 KSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPI------------- 880
S SSS ++S+S++ S+ + + ++P+ + R P
Sbjct: 2535 SSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGR 2594
Query: 881 SPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSEN 940
P +K K S +SSS + +S +S+SSS + S + ++ + ++
Sbjct: 2595 PPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP 2654
Query: 941 IPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDM--PRSADYFMQEAKR 986
P +P + P G R + + D + RS Y E +R
Sbjct: 2655 GPQALPKPASPKKPP--PGERRSRSPRKPIDSLRDSRSLSYSPVERRR 2700
Score = 47.8 bits (112), Expect = 7e-05
Identities = 131/690 (18%), Positives = 246/690 (35%), Gaps = 72/690 (10%)
Query: 382 QAAQRTALRALSDS-AVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETES 440
++ RT R S S ++V++ + P +G S SSS + S S+ S S+S E
Sbjct: 691 RSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSE-RKNKSRTSQRRSRSNSSPEM 749
Query: 441 SSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPV 500
S + SSP ++ + ++ L + L+ +P P Q S S
Sbjct: 750 KKSRISSRRSRSLSSPRSK--AKSRLSLRRSLSGSSP-CPKQKSQTPPRRSRSGSSQPKA 806
Query: 501 KEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSA 560
K + P S K K R ++ +P K VK +PP ++
Sbjct: 807 K------SRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK-VKSGTPPRQGSITSPQ 859
Query: 561 AAPPPAVPCAPA--ENAPAPARRSAGKKPTRRTERTSAGDGANCHRP--EEPAAADALGT 616
A P + E++P P +S + P+R + S+ P + P+ + +
Sbjct: 860 ANEQSVTPQRRSCFESSPDPELKS--RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQP 917
Query: 617 SVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSS 676
V P + G++ S R + RR+R +S + S S SSS
Sbjct: 918 KVKAIISPRQRSHSGSSSPS---PSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSS 974
Query: 677 SDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAK 736
D+ + K +T + SG+ + A GP S++ + +
Sbjct: 975 PDTKV----------KPETPPRQSHSGSISPYPKVKAQTPPGP-----SLSGSKSPCPQE 1019
Query: 737 ELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKD 796
+ ++ P G L + +K S + + L + P S+P +
Sbjct: 1020 KSKDSLVQSCP-GSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQ 1078
Query: 797 SESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSAN 856
S S PS S + +S+ I++ +GE +S L + +S
Sbjct: 1079 SHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSG----MSPE 1134
Query: 857 HCNMNINSVAIP-INKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSK 915
+S + P ++ N + +S + K ++ ++S P F+
Sbjct: 1135 QSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQD 1194
Query: 916 KPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWS-PGSNGHRDCKRQKLVFDDMP 974
+P E+ + K +T P G+ + K Q +P
Sbjct: 1195 RP---------------------ESSLVFKDTLRTPPRERSGAGSSPETKEQN---SALP 1230
Query: 975 RSA--DYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMY 1032
S+ + M+ ++ + A ++ L E + S E +E+ P S +
Sbjct: 1231 TSSQDEELMEVVEKSEEPAGQILSHLSSELK--EMSTSNFESSPEVEERPAVSLTLDQSQ 1288
Query: 1033 SE-TVELIRYAMRLKTHSGPNATPEDKQLA 1061
S+ ++E + + GP+ +PE K+L+
Sbjct: 1289 SQASLEAVEVPSMASSWGGPHFSPEHKELS 1318
Score = 46.2 bits (108), Expect = 2e-04
Identities = 158/766 (20%), Positives = 250/766 (32%), Gaps = 157/766 (20%)
Query: 246 DESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLS-------KFSIPKQGEE-----S 293
+ SP++K S +S R S P ++AK++LS PKQ + S
Sbjct: 744 NSSPEMKKS-----RISSRRSRSLSSPR-SKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS 797
Query: 294 RSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEP 353
RSG + + + PP + + K P++ S SS H K G
Sbjct: 798 RSGSSQP------KAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPR 851
Query: 354 ESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGS 413
+ + S E + + RT R + P ++S P +
Sbjct: 852 QGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGS--SPPRVKSSTPPRQSP 909
Query: 414 SSSSSSG-------SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAE--PASSN 464
S SSS S S S SSS S S S ++ S+ E+ P S+
Sbjct: 910 SRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSH 969
Query: 465 KWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIK 524
KV P PP +SH + Y KV P K
Sbjct: 970 SGSSSPD-TKVKPETPP----RQSHSGSISPY-----------PKVKAQTPPGPSLSGSK 1013
Query: 525 STCKEEQ-RPRTANKAPGS----KGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPA 579
S C +E+ + PGS GVK +PP VS+ ++ +P
Sbjct: 1014 SPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQ-------LKGQSQTSPD 1066
Query: 580 RRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRK 639
RS P R + E P+ ++T P G S
Sbjct: 1067 HRSDTSSPEVRQSHS-----------ESPSLQSK-----------SQTSPKGGRSRSSSP 1104
Query: 640 ELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAAS 699
+ R+ RG P K S S S +S+ YP TV ++
Sbjct: 1105 VTELASRSPIRQDRGEFSASPMLK--------SGMSPEQSRFQSDSSSYP-----TVDSN 1151
Query: 700 ASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKD 759
+ G RL+ A + +A +E T P + + SP
Sbjct: 1152 SLLGQS-RLE-----------------TAESKEKMALPPQEDA-TASPPRQKDKFSPFPV 1192
Query: 760 SDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKR 819
D S V D R P + G S+P TK+ SA P+ + D + + KS+
Sbjct: 1193 QDRPESSLVFKDTL---RTPPR--ERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEE 1247
Query: 820 ---KRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIP-------- 868
+ + +E+ S E + S TL + ++ +V +P
Sbjct: 1248 PAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGG 1307
Query: 869 ---INKNEKMLRSPI--------------SPLSDASKHKYTSEDLTSSSRPNGNSLFTSA 911
+++++ SP+ PL ++SE + P N L T
Sbjct: 1308 PHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDP 1367
Query: 912 SSSKKPK-------ADSQLQPHGGDLTKAAHNNSENIPLHKSRPQT 950
S K + + S+L P + + N S + P+ + P+T
Sbjct: 1368 SLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRT 1413
Score = 41.2 bits (95), Expect = 0.006
Identities = 146/715 (20%), Positives = 242/715 (33%), Gaps = 135/715 (18%)
Query: 218 PSLASKPSLVQQKPTAYVRPMDGQDQAPD-------ESPKLKSSSETSVHCTSYRGVPAS 270
P SK SLVQ P + + P S +LK S+TS S P
Sbjct: 1017 PQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEV 1076
Query: 271 KPEPARAKAKLSKFSIPKQGEESRSGE------TNSCVEEIIREMTWLPPLSAIQAPGKV 324
+ + + + SK +G SRS + S + + E + P L + +P
Sbjct: 1077 RQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSP--- 1133
Query: 325 EPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAA 384
E ++F DS + +N G + E+ ++ ++D S ++++
Sbjct: 1134 EQSRF---QSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPF 1190
Query: 385 QRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSE 444
++ +S++V + RT G+ SS + +S+ + S E S E
Sbjct: 1191 P---VQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEE 1247
Query: 445 SEGSKPPHFSSPEAEPASSN------------------------------------KW-- 466
G H SS E ++SN W
Sbjct: 1248 PAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGG 1307
Query: 467 --------QLDKWLNKVNPHKPPILIQNESH-GSESNQ-YYNPVKEDVQDCGKVPDVCQP 516
+L + N P+ +N G+E N + + VKED+ P
Sbjct: 1308 PHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDP 1367
Query: 517 SLREKEIKST-----CKEEQRPRTANKAPGSKGVKQKSPPAAVAV--------AVSAAAP 563
SL KE +ST E P KA G + S P AV + SA++P
Sbjct: 1368 SLDMKE-QSTRSSGHSSSELSPDAVEKA-GMSSNQSISSPVLDAVPRTPSRERSSSASSP 1425
Query: 564 P-----PAVPCAPAENAPAPARRSAGKKPTRRT-----------ERTSAGDGANCHRPEE 607
P P + + +P R P+R + RT + + C E
Sbjct: 1426 EMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPE 1485
Query: 608 PAAADALGTSVVVPPEPTKTRPCG---NNRA-SHRKELRSSVTCEKRRTRGLSRIVPKSK 663
P A + P P P NN+ + ++E S + ++T + + +S+
Sbjct: 1486 PKA-------LPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSR 1538
Query: 664 EFIETESSSSSSSSDSDLESEQEEYPLSKAQT---------VAASASSGNDQRLKEAAAN 714
E S+S + SE + P SKA+T +S + RL +
Sbjct: 1539 SGSSQELDVKPSASPQE-RSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR 1597
Query: 715 GGSGPRA---PVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKID 771
GS P P + A++ SD + E + +P R+ S K
Sbjct: 1598 SGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALP-RRSRSGSSSKGRGPSPE-----G 1651
Query: 772 LTLLSRIPEHLPQ----EPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRK 822
+ PEH P+ G S+P K PP S + + K++ R+
Sbjct: 1652 SSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRR 1706
Score = 40.4 bits (93), Expect = 0.010
Identities = 147/716 (20%), Positives = 245/716 (34%), Gaps = 116/716 (16%)
Query: 330 PFPNKDSQLV----SSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQ 385
P P K LV SS PK+ + + S +S + K SS ++++ ++
Sbjct: 165 PEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESES 224
Query: 386 RTAL--------RALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGS--- 434
+ + S ++ T P S+ + S+S+ S+SSS S S S S
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAA 284
Query: 435 ---------DSETESSSSESEGSKP---------PHFSSPE--AEPASSNKWQLDKWLNK 474
S + +S EG P SSPE + SS DK +
Sbjct: 285 KTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKE 344
Query: 475 VNPHKPPILIQNESHGSESNQYYNPVKE----DVQDCGKVPDVCQPSLREKEIKSTCKEE 530
+ +P + S G E + E Q P + Q + S ++
Sbjct: 345 KSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTP-LSQEPVNPPSEASPTRDR 403
Query: 531 QRPRTANKAPGSKGVKQKSPPAAVAVAVS--AAAPPPAVPCAPA-------ENAPAPARR 581
P++ K P S + SPP+ VS A++ P + APA ++P R
Sbjct: 404 SPPKSPEKLPQSSS-SESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNR 462
Query: 582 SAGKKPTRRTERTSAGDGANCHRPEEPAAA----------DALGTSVVVPPEPTKTRPC- 630
S G+ +R + S R PA A G S P+ ++R
Sbjct: 463 SHGR--AKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQ 520
Query: 631 --GNNRASHRKELRSS------VTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLE 682
G +R+ R+ S + RG SR + + + ++ S S +
Sbjct: 521 RWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPAR 580
Query: 683 SEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQF 742
+ + + + R + A G S R P +RT S + +
Sbjct: 581 RGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR-RSRTRSPVRR------ 633
Query: 743 YTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPP 802
R+ SP + S RS SR P + PA + S
Sbjct: 634 -------RSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRS--RTPARRSGRS--- 681
Query: 803 SHTSDTPAEKALPKSKRKRKCDNED--------DYREIKKSQGEKDSSS--RLATSTSNT 852
S TPA + +S+ R+ + + + +G SSS + + TS
Sbjct: 682 --RSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR 739
Query: 853 LSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS----RPNGNSLF 908
S ++ + + I + + RS SP S A L+ SS + +
Sbjct: 740 RSRSNSSPEMKKSRI----SSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR 795
Query: 909 TSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHRDCK 964
S S S +PKA S+ P + + ++S P KS+ ++ S+ H K
Sbjct: 796 RSRSGSSQPKAKSRTPP------RRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK 845
Score = 40.0 bits (92), Expect = 0.014
Identities = 74/360 (20%), Positives = 116/360 (32%), Gaps = 54/360 (15%)
Query: 377 EENEQQAAQRTALRALSDSAV-------------VQQPNCRTSVPSSKGSSSSSSSGSSS 423
E NE++ + A +SDS V +QP P S SSSS +
Sbjct: 126 ELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTP 185
Query: 424 SSSDSESSSGSDSETESSSSESE----GSKPPHFSSPEAE------PASSNKWQLDKWLN 473
+ +ESSS E K H S E++ P +K +
Sbjct: 186 KQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKR 245
Query: 474 KVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIK--STCKEEQ 531
K + P +H S S D D + R K +T +
Sbjct: 246 KRSRSTTPAPKSRRAHRSTS-----------ADSASSSDTSRSRSRSAAAKTHTTALAGR 294
Query: 532 RPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRT 591
P A+ G P S+ P +P E+ + + +P+
Sbjct: 295 SPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSP 354
Query: 592 ERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRR 651
ER+S G PE PA L P+P T P + E +
Sbjct: 355 ERSSTG-------PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPT------- 400
Query: 652 TRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEA 711
R PKS E + +SSSS SS S ++ + S ++ + + G+ + + +
Sbjct: 401 ---RDRSPPKSPEKL-PQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSS 456
>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
sapiens]
Length = 1082
Score = 57.4 bits (137), Expect = 8e-08
Identities = 50/151 (33%), Positives = 65/151 (43%), Gaps = 9/151 (5%)
Query: 340 SSGHNNP-KKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVV 398
S G + P + D++PES S +S E SS E +NE Q R
Sbjct: 681 SEGESGPTESADSDPESESESDSKSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSE 739
Query: 399 QQPNCRTS--VPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSP 456
+ +T VP KG +SSS GS SSSS SES S+SE E S K P S
Sbjct: 740 EDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTP--PSS 797
Query: 457 EAEPASSNKWQLDK---WLNKVNPHKPPILI 484
++ PA+ LD V P PP ++
Sbjct: 798 KSAPATKEISLLDLEDFTPPSVQPVSPPAIV 828
Score = 38.1 bits (87), Expect = 0.052
Identities = 45/170 (26%), Positives = 66/170 (38%), Gaps = 17/170 (10%)
Query: 399 QQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEA 458
++P S S + S+ S S S SDS+SSS S S SS S++E +
Sbjct: 674 EKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGS 733
Query: 459 EPASSNKWQLDKWLNKVNPHKPPILIQNE-----SHGSESNQYYNPVKEDVQDCG---KV 510
E S + K KV K +E S SES +E ++ K
Sbjct: 734 ESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKT 793
Query: 511 PDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSA 560
P + + KEI E+ P V+ SPPA V+ +++A
Sbjct: 794 PPSSKSAPATKEISLLDLEDFTP---------PSVQPVSPPAIVSTSLAA 834
Score = 32.7 bits (73), Expect = 2.2
Identities = 46/213 (21%), Positives = 76/213 (35%), Gaps = 12/213 (5%)
Query: 605 PEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIV---PK 661
P+ P A V PE TK C N RKE + G + P+
Sbjct: 642 PDWPEEAPDPSVRNVEVPEWTK---CSNREK--RKEKEKPFYSDSEGESGPTESADSDPE 696
Query: 662 SKEFIETESSSSS----SSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGS 717
S+ +++SSS S SSS+SD E + E+ + S G + K+ G
Sbjct: 697 SESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGE 756
Query: 718 GPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSR 777
+ GS ++ ++S+ E + L P + P S +DL +
Sbjct: 757 ASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTP 816
Query: 778 IPEHLPQEPGVLSAPATKDSESAPPSHTSDTPA 810
P ++S D E + ++ P+
Sbjct: 817 PSVQPVSPPAIVSTSLAADLEGLTLTDSTLVPS 849
>gi|6857826 RNA-binding protein S1, serine-rich domain [Homo
sapiens]
Length = 305
Score = 57.4 bits (137), Expect = 8e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP- 565
+ + P R S E + P A KA Q A AV A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPP 246
Query: 566 ---------AVPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|18379334 RNA-binding protein S1, serine-rich domain [Homo
sapiens]
Length = 305
Score = 57.4 bits (137), Expect = 8e-08
Identities = 76/290 (26%), Positives = 104/290 (35%), Gaps = 19/290 (6%)
Query: 334 KDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLK-LSSDEEENEQQAAQRTALRAL 392
K L+ NN K P + +D K + +E +E+ + +
Sbjct: 7 KKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRR 66
Query: 393 SDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSET-ESSSSESEGSKPP 451
S S+ R+S SS GSS+S+ S S SSSS + S SGS S + SSSS S GS P
Sbjct: 67 SASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
Query: 452 HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSE--SNQYYNPVKEDVQDCGK 509
+ S +K + K K + P + H N + + E GK
Sbjct: 127 SRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGK 186
Query: 510 VPDVCQPSLREKEIKS---TCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPP- 565
+ + P R S E + P A KA Q A AV A P P
Sbjct: 187 IKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPP 246
Query: 566 ---------AVPCAPAENAPAPARRSAGKKPTRRT--ERTSAGDGANCHR 604
+P P P R + P RR+ R S G HR
Sbjct: 247 PRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHR 296
Score = 35.4 bits (80), Expect = 0.34
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 622 PEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL 681
P PTK + + ++ R + + + + RG + + + S+ S SSS S
Sbjct: 26 PSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSS 85
Query: 682 ESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAP 722
S S + + +AS+ SG+ + ++++ SG +P
Sbjct: 86 GSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSP 126
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/259 (23%), Positives = 98/259 (37%), Gaps = 24/259 (9%)
Query: 269 ASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTK 328
+ +P P + + F P+ + VE+ R+ P + + G+V
Sbjct: 505 SQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPP 564
Query: 329 FP-----FPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLED-DLKLSSDEEENEQQ 382
P F N +S+ V P AEP+ P TS + +L D L ++N Q
Sbjct: 565 VPSRSESFSNGNSESVHPALQRP----AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQ- 619
Query: 383 AAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSS 442
A QR + ++ + ++ P S SS SS+SGS S S + SS
Sbjct: 620 AGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSS 679
Query: 443 SESEGSKPPHFSSPEAEPASSNK-------------WQLDKWLNKVNPHKPPILIQNESH 489
S+SEGS + +P + L K L V +PP + + S
Sbjct: 680 SKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSS 739
Query: 490 GSESNQYYNPVKEDVQDCG 508
SE + + +DV+ G
Sbjct: 740 SSEESGTTDEEDDDVEQEG 758
>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
Length = 2089
Score = 55.5 bits (132), Expect = 3e-07
Identities = 108/519 (20%), Positives = 189/519 (36%), Gaps = 79/519 (15%)
Query: 199 PPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDES---------P 249
PP S H PP L S P L KPT DG +AP+ P
Sbjct: 1048 PPQKPLNSQSQKHLA---PPPLLS-PLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHP 1103
Query: 250 KLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCV---EEII 306
K K + S T + A+ PEP + + + + +RS S V E ++
Sbjct: 1104 KPKIRTRKSSRMTPFPATSAA-PEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVV 1162
Query: 307 REMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSML 366
L P ++ P EPT SQ+ +K + ++P+ T + L
Sbjct: 1163 PTAPELQPSTSTDQPVTSEPT--------SQVTRG-----RKSRSSVKTPE--TVVPTAL 1207
Query: 367 EDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSS 426
E S+D + +Q T R S +P VP++ S+S+ +S
Sbjct: 1208 ELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEP----VVPTAPELQPSTSTDQPVTSE 1263
Query: 427 DSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQN 486
+ ++ + S + +P ++PE P++S P+ +
Sbjct: 1264 PTYQATRG----RKNRSSVKTPEPVVPTAPELRPSTSTD--------------RPVTPKP 1305
Query: 487 ESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVK 546
S + S + VK P+ P+ E +I ++ + P+ P S+ +
Sbjct: 1306 TSRTTRSRTNMSSVK--------TPETVVPTAPELQISTSTDQPVTPK-----PTSRTTR 1352
Query: 547 QKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPE 606
++ ++V S P +P P+ + P + TR + S+G P
Sbjct: 1353 SRTNMSSVKNPESTVPIAPELP--PSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPT 1410
Query: 607 EPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSK--E 664
P + T V PEPT ++A+ + RSSV + + P + +
Sbjct: 1411 APKLEPSTSTDQPVTPEPT-------SQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQ 1463
Query: 665 FIETESSSSSSSSDSDLES-EQEEYPLSKAQTVAASASS 702
+ E +S ++ +D S + E + A + ASAS+
Sbjct: 1464 PVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASAST 1502
Score = 41.2 bits (95), Expect = 0.006
Identities = 96/481 (19%), Positives = 166/481 (34%), Gaps = 88/481 (18%)
Query: 198 RPPAMAAKHSSSGHCVQNFPPSLASKPSL---------VQQKPTAYV---RPMDGQDQAP 245
+P + A + ++ V+ P + + P L V +PT+ V R + P
Sbjct: 1140 KPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTP 1199
Query: 246 DE----SPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSC 301
+ + +L+ S+ T TS A++ R+ K + +P E S T+
Sbjct: 1200 ETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQP 1259
Query: 302 V--EEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNG 359
V E + S+++ P V PT + P P +P
Sbjct: 1260 VTSEPTYQATRGRKNRSSVKTPEPVVPT-------------APELRPSTSTDRPVTP-KP 1305
Query: 360 TSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSS 419
TS T+ ++ S E A + +D V +P RT+ + SS +
Sbjct: 1306 TSRTTRSRTNMS-SVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPE 1364
Query: 420 GS---------SSSSSDSESSSGSDSETESSSSESEGSKPPHF--SSPEAEPASSNKWQL 468
+ S+S+ + + T + S G P ++P+ EP++S
Sbjct: 1365 STVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTD--- 1421
Query: 469 DKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCK 528
P+ + S + + VK P+ P+ E + ++
Sbjct: 1422 -----------QPVTPEPTSQATRGRTNRSSVK--------TPETVVPTAPELQPSTSTD 1462
Query: 529 EEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPT 588
+ P ++A ++G +S S P VP AP A A + +PT
Sbjct: 1463 QPVTPEPTSQA--TRGRTDRS---------SVKTPETVVPTAPELQASASTDQPVTSEPT 1511
Query: 589 RRTER----TSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSS 644
RT R S+ P P + T V PEPT +RA+ + RSS
Sbjct: 1512 SRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPT-------SRATRGRTNRSS 1564
Query: 645 V 645
V
Sbjct: 1565 V 1565
Score = 40.4 bits (93), Expect = 0.010
Identities = 130/653 (19%), Positives = 225/653 (34%), Gaps = 106/653 (16%)
Query: 86 RSNQSHLVGVPKPGVPQTPV----NKIDEHFVAD-----SRAQNQPSSICSTTTSTPAAV 136
R+N+S V P+P VP P D+ ++ +R + SS+ + T P A+
Sbjct: 1149 RTNRSS-VKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTAL 1207
Query: 137 PVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQ 196
+Q S + P S + + S++T + V P + + + + ++
Sbjct: 1208 ELQPST--STDRPVTSEPTSQATRGRKNRSSVKT--PEPVVPTAPELQPSTSTDQPVTSE 1263
Query: 197 ERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSS- 255
P A + + V+ P + + P L + T+ RP+ + + + SS
Sbjct: 1264 --PTYQATRGRKNRSSVKTPEPVVPTAPEL--RPSTSTDRPVTPKPTSRTTRSRTNMSSV 1319
Query: 256 ---ETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCV---EEIIREM 309
ET V + S +P K +RS S V E +
Sbjct: 1320 KTPETVVPTAPELQISTSTDQPVTPKPT---------SRTTRSRTNMSSVKNPESTVPIA 1370
Query: 310 TWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDD 369
LPP ++ + P EPT + G N G ++P+ LE
Sbjct: 1371 PELPPSTSTEQPVTPEPTS---------RATRGRKNRSSG----KTPETLVPTAPKLEPS 1417
Query: 370 LKLSSDEEENEQQAAQRTALRALSDS----------AVVQQPNCRTSVPSSKGSSSSSSS 419
S+D+ + +Q T R S A QP+ T P + +S ++
Sbjct: 1418 T--STDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATR 1475
Query: 420 GSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHK 479
G + SS + + E +S S + P S P + K N+ +
Sbjct: 1476 GRTDRSSVKTPETVVPTAPELQASAS--TDQPVTSEPTSRTTRGRK-------NRSSVKT 1526
Query: 480 PPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKA 539
P ++ S PV + + S++ E E +P T+
Sbjct: 1527 PETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQ 1586
Query: 540 -----PGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRR-TER 593
P S+ + ++ ++V P P VP AP + + K T R T R
Sbjct: 1587 LVTPEPTSRATRCRTNRSSVKT------PEPVVPTAPEPHPTTSTDQPVTPKLTSRATRR 1640
Query: 594 TSAGDGANCHRPEEPAAADALGTSVVVPPEPT--KTRPCGNNRASHRKELRSSVTCEKRR 651
+ +P EPAA+D + P PT P + K LRSS
Sbjct: 1641 KTNRSSVKTPKPVEPAASD------LEPFTPTDQSVTPEAIAQGGQSKTLRSSTV----- 1689
Query: 652 TRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGN 704
+ VP + EF S ++D + E P+++ + ++GN
Sbjct: 1690 ---RAMPVPTTPEF------QSPVTTDQPISPE----PITQPSCIKRQRAAGN 1729
>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
sapiens]
Length = 2462
Score = 55.5 bits (132), Expect = 3e-07
Identities = 116/527 (22%), Positives = 185/527 (35%), Gaps = 86/527 (16%)
Query: 330 PFPNKDSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTAL 389
P P + SQ K+ + E E P+ +L++ +S E+ +E++A
Sbjct: 511 PMP-RSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKG- 568
Query: 390 RALSDSAVVQQPNCRTSVPSSKGSSSS---SSSGSSSSSSDSESSSGSDSETE------- 439
R ++S ++ S+ + S + S +S +ESS ++ E E
Sbjct: 569 RKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLL 628
Query: 440 ------SSSSESEGSKPP------HFSSPEA----EPASSNKWQLDKWLNKVNPHKPPIL 483
S+ + GSK +F+ + E +K +++K N K
Sbjct: 629 EHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKK---- 684
Query: 484 IQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKE--IKSTCKEEQRPRTANKAPG 541
+ + SE + V+++ + V + + E E + ++ E P +A
Sbjct: 685 -KAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAK 743
Query: 542 SKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGAN 601
G PPA + A PPP P P E+ PAP +PT +E T A
Sbjct: 744 DTGQNGPKPPATLG----ADGPPPGPPTPPPEDIPAPT------EPTPASEATGA----- 788
Query: 602 CHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPK 661
P P A PP P+ P KE + T P
Sbjct: 789 ---PTPPPA----------PPSPSAPPPV------VPKEEKEEETAAAPPVEEGEEQKPP 829
Query: 662 SKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSG--- 718
+ E + ++ + S+ E EE P AA A++ + LK GGSG
Sbjct: 830 AAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATA--EGALKAEKKEGGSGRAT 887
Query: 719 ----PRAPVGSINARTTS-DIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLT 773
AP S ++ T S D E E + R LL+P D S +DL
Sbjct: 888 TAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLK 947
Query: 774 LLSRIPEHLP-------QEPGVLSAPATKDSESAPPSHTSDTPAEKA 813
L + +P EP A TK + APP + P A
Sbjct: 948 QLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDA 994
Score = 38.1 bits (87), Expect = 0.052
Identities = 68/312 (21%), Positives = 105/312 (33%), Gaps = 68/312 (21%)
Query: 337 QLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSA 396
Q SS H++ P P + T T+ + + D E + + +++ L S +
Sbjct: 1757 QPFSSRHSS---SPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILT--STTT 1811
Query: 397 VVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSP 456
V P R S GSS SS G SSS + + S + + P +
Sbjct: 1812 VEHAPIWRPGTEQSSGSSGSSGGGGGSSSRPA---------SHSHAHQHSPISPRTQDAL 1862
Query: 457 EAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVK-----EDVQDC---- 507
+ P+ + + + V P P +L S +PV+ C
Sbjct: 1863 QQRPSVLHNTGMKGIITAVEPSTPTVL--------RSTSTSSPVRPAATFPPATHCPLGG 1914
Query: 508 ---GKVPDVCQPSLREKEIKSTCKEEQRPRTAN------KAPGSKGVKQKSPPA------ 552
G P + +P L KE + E RPR K P G++ S P+
Sbjct: 1915 TLDGVYPTLMEPVLLPKEAPRVARPE-RPRADTGHAFLAKPPARSGLEPASSPSKGSEPR 1973
Query: 553 ----------------AVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKP--TRRTERT 594
A +A A+P P P A A + P R KP + E
Sbjct: 1974 PLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASD---PHREKTQSKPFSIQELELR 2030
Query: 595 SAGDGANCHRPE 606
S G + + PE
Sbjct: 2031 SLGYHGSSYSPE 2042
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.122 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,450,719
Number of Sequences: 37866
Number of extensions: 2789212
Number of successful extensions: 33370
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 306
Number of HSP's successfully gapped in prelim test: 973
Number of HSP's that attempted gapping in prelim test: 20094
Number of HSP's gapped (non-prelim): 8584
length of query: 1226
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1112
effective length of database: 13,930,794
effective search space: 15491042928
effective search space used: 15491042928
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.