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Search of human proteins with 68303575
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
(365 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens] 741 0.0
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 671 0.0
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 619 e-177
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 461 e-130
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 461 e-130
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 459 e-129
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 459 e-129
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens] 323 2e-88
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens] 323 2e-88
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens] 323 2e-88
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens] 323 2e-88
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens] 323 2e-88
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens] 322 3e-88
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 161 1e-39
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 155 7e-38
gi|4507903 vaccinia related kinase 1 [Homo sapiens] 108 1e-23
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens] 104 1e-22
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens] 104 1e-22
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens] 104 1e-22
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens] 104 1e-22
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens] 103 2e-22
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens] 86 5e-17
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 63 4e-10
gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens] 60 3e-09
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 59 9e-09
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 59 9e-09
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 59 9e-09
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 59 9e-09
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 56 4e-08
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 55 8e-08
>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
Length = 365
Score = 741 bits (1912), Expect = 0.0
Identities = 365/365 (100%), Positives = 365/365 (100%)
Query: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
Sbjct: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
Query: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ 180
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ
Sbjct: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ 180
Query: 181 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 240
LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM
Sbjct: 181 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 240
Query: 241 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 300
YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP
Sbjct: 241 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 300
Query: 301 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 360
DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS
Sbjct: 301 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 360
Query: 361 NMKGF 365
NMKGF
Sbjct: 361 NMKGF 365
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 671 bits (1730), Expect = 0.0
Identities = 337/365 (92%), Positives = 337/365 (92%), Gaps = 28/365 (7%)
Query: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
Sbjct: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
Query: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ 180
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNK
Sbjct: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNK---------------------------- 152
Query: 181 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 240
LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM
Sbjct: 153 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 212
Query: 241 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 300
YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP
Sbjct: 213 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 272
Query: 301 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 360
DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS
Sbjct: 273 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 332
Query: 361 NMKGF 365
NMKGF
Sbjct: 333 NMKGF 337
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 619 bits (1596), Expect = e-177
Identities = 307/363 (84%), Positives = 318/363 (87%), Gaps = 28/363 (7%)
Query: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
M ++SGSKAE +VGGKYKLVRKIGSGSFGD+YL I TNGEEVAVKLESQK +HPQLLYE
Sbjct: 1 MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYE 60
Query: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLY ILQGGVGIPH+ WYGQEKD NVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ 180
ISRIEYVHTKNF+HRDIKPDNFLMG GRHCNK
Sbjct: 121 ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNK---------------------------- 152
Query: 181 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 240
LFLIDFGLAKKYRDNRTRQHIPYREDK+L GT RYASINAHLGIEQSRRDDMESLGYV M
Sbjct: 153 LFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFM 212
Query: 241 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 300
YFNRTSLPWQGLKA TKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEE P
Sbjct: 213 YFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVP 272
Query: 301 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 360
DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQT TGKQT+K K+
Sbjct: 273 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTQTGKQTEKNKN 332
Query: 361 NMK 363
N+K
Sbjct: 333 NVK 335
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 461 bits (1185), Expect = e-130
Identities = 225/326 (69%), Positives = 258/326 (79%), Gaps = 28/326 (8%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG KY+L RKIGSGSFGDIYL NI +GEEVA+KLE K +HPQL ESK YK++QG
Sbjct: 2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP I+W G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLA 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLA
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNL----------------------------VYIIDFGLA 153
Query: 190 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 249
KKYRD RT QHIPYRE+KNLTGTARYASIN HLGIEQSRRDD+ESLGYVLMYFN SLPW
Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213
Query: 250 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 309
QGLKAATK+QKYE+ISEKKMSTP+EVLCKG+P+EF+ YLN+CR LRF++ PDY YLRQLF
Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLF 273
Query: 310 RILFRTLNHQYDYTFDWTMLKQKAAQ 335
R LF YDY FDW MLK AA+
Sbjct: 274 RNLFHRQGFSYDYVFDWNMLKFGAAR 299
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 461 bits (1185), Expect = e-130
Identities = 225/326 (69%), Positives = 258/326 (79%), Gaps = 28/326 (8%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG KY+L RKIGSGSFGDIYL NI +GEEVA+KLE K +HPQL ESK YK++QG
Sbjct: 2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP I+W G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLA 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLA
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNL----------------------------VYIIDFGLA 153
Query: 190 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 249
KKYRD RT QHIPYRE+KNLTGTARYASIN HLGIEQSRRDD+ESLGYVLMYFN SLPW
Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213
Query: 250 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 309
QGLKAATK+QKYE+ISEKKMSTP+EVLCKG+P+EF+ YLN+CR LRF++ PDY YLRQLF
Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLF 273
Query: 310 RILFRTLNHQYDYTFDWTMLKQKAAQ 335
R LF YDY FDW MLK AA+
Sbjct: 274 RNLFHRQGFSYDYVFDWNMLKFGAAR 299
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 459 bits (1181), Expect = e-129
Identities = 225/328 (68%), Positives = 259/328 (78%), Gaps = 28/328 (8%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG +Y+L RKIGSGSFGDIYL +I GEEVA+KLE K +HPQL ESK+YK++QG
Sbjct: 2 ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP IRW G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLA 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLA
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNL----------------------------VYIIDFGLA 153
Query: 190 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 249
KKYRD RT QHIPYRE+KNLTGTARYASIN HLGIEQSRRDD+ESLGYVLMYFN SLPW
Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213
Query: 250 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 309
QGLKAATK+QKYE+ISEKKMSTP+EVLCKG+P+EFA YLN+CR LRF++ PDY YLRQLF
Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLF 273
Query: 310 RILFRTLNHQYDYTFDWTMLKQKAAQQA 337
R LF YDY FDW MLK A++ A
Sbjct: 274 RNLFHRQGFSYDYVFDWNMLKFGASRAA 301
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 459 bits (1181), Expect = e-129
Identities = 225/328 (68%), Positives = 259/328 (78%), Gaps = 28/328 (8%)
Query: 10 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQG 69
E VG +Y+L RKIGSGSFGDIYL +I GEEVA+KLE K +HPQL ESK+YK++QG
Sbjct: 2 ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQG 61
Query: 70 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP IRW G E DYNV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLA 189
KNFIHRD+KPDNFLMG+G+ N +++IDFGLA
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNL----------------------------VYIIDFGLA 153
Query: 190 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 249
KKYRD RT QHIPYRE+KNLTGTARYASIN HLGIEQSRRDD+ESLGYVLMYFN SLPW
Sbjct: 154 KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213
Query: 250 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 309
QGLKAATK+QKYE+ISEKKMSTP+EVLCKG+P+EFA YLN+CR LRF++ PDY YLRQLF
Sbjct: 214 QGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLF 273
Query: 310 RILFRTLNHQYDYTFDWTMLKQKAAQQA 337
R LF YDY FDW MLK A++ A
Sbjct: 274 RNLFHRQGFSYDYVFDWNMLKFGASRAA 301
>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
Length = 415
Score = 323 bits (827), Expect = 2e-88
Identities = 165/324 (50%), Positives = 217/324 (66%), Gaps = 26/324 (8%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
SS S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 32 SSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYR 91
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G+P + ++G YN +V++LLGPSLEDLF+ C R FT+KTVLM+A Q+I+
Sbjct: 92 FYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLIT 151
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLF 182
R+EYVHTK+ I+RD+KP+NFL+G P KR+ + +
Sbjct: 152 RMEYVHTKSLIYRDVKPENFLVG----------RPGTKRQHA----------------IH 185
Query: 183 LIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYF 242
+IDFGLAK+Y D T++HIPYRE K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF
Sbjct: 186 IIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF 245
Query: 243 NRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDY 302
R SLPWQGLKA T K++Y+KI + K +TP+EVLC+ FP E A YL Y R L F E PDY
Sbjct: 246 LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDY 305
Query: 303 MYLRQLFRILFRTLNHQYDYTFDW 326
YLR+LF LF +DY +DW
Sbjct: 306 DYLRKLFTDLFDRSGFVFDYEYDW 329
>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
Length = 455
Score = 323 bits (827), Expect = 2e-88
Identities = 167/324 (51%), Positives = 218/324 (67%), Gaps = 27/324 (8%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLF 182
R+EYVH+KN I+RD+KP+NFL IGR NK + +
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQ------------------------VIH 182
Query: 183 LIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYF 242
+IDFGLAK+Y D T++HIPYRE K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF
Sbjct: 183 IIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF 242
Query: 243 NRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDY 302
R SLPWQGLKA T K++Y+KI + K +TP+EVLC+ FP E A YL Y R L F E PDY
Sbjct: 243 LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDY 301
Query: 303 MYLRQLFRILFRTLNHQYDYTFDW 326
YLR+LF LF + +DY +DW
Sbjct: 302 DYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
Length = 415
Score = 323 bits (827), Expect = 2e-88
Identities = 167/324 (51%), Positives = 218/324 (67%), Gaps = 27/324 (8%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLF 182
R+EYVH+KN I+RD+KP+NFL IGR NK + +
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQ------------------------VIH 182
Query: 183 LIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYF 242
+IDFGLAK+Y D T++HIPYRE K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF
Sbjct: 183 IIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF 242
Query: 243 NRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDY 302
R SLPWQGLKA T K++Y+KI + K +TP+EVLC+ FP E A YL Y R L F E PDY
Sbjct: 243 LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDY 301
Query: 303 MYLRQLFRILFRTLNHQYDYTFDW 326
YLR+LF LF + +DY +DW
Sbjct: 302 DYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
Length = 423
Score = 323 bits (827), Expect = 2e-88
Identities = 167/324 (51%), Positives = 218/324 (67%), Gaps = 27/324 (8%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLF 182
R+EYVH+KN I+RD+KP+NFL IGR NK + +
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQ------------------------VIH 182
Query: 183 LIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYF 242
+IDFGLAK+Y D T++HIPYRE K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF
Sbjct: 183 IIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF 242
Query: 243 NRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDY 302
R SLPWQGLKA T K++Y+KI + K +TP+EVLC+ FP E A YL Y R L F E PDY
Sbjct: 243 LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDY 301
Query: 303 MYLRQLFRILFRTLNHQYDYTFDW 326
YLR+LF LF + +DY +DW
Sbjct: 302 DYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
Length = 447
Score = 323 bits (827), Expect = 2e-88
Identities = 167/324 (51%), Positives = 218/324 (67%), Gaps = 27/324 (8%)
Query: 3 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESK 62
+ S S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E +
Sbjct: 29 TGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYR 88
Query: 63 LYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIS 122
YK L G GIP + ++G YN +V++LLGPSLEDLF+ C R F++KTVLM+A Q+IS
Sbjct: 89 FYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLIS 148
Query: 123 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLF 182
R+EYVH+KN I+RD+KP+NFL IGR NK + +
Sbjct: 149 RMEYVHSKNLIYRDVKPENFL--IGRPGNKTQQ------------------------VIH 182
Query: 183 LIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYF 242
+IDFGLAK+Y D T++HIPYRE K+LTGTARY SIN HLG EQSRRDD+E+LG++ MYF
Sbjct: 183 IIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF 242
Query: 243 NRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDY 302
R SLPWQGLKA T K++Y+KI + K +TP+EVLC+ FP E A YL Y R L F E PDY
Sbjct: 243 LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDY 301
Query: 303 MYLRQLFRILFRTLNHQYDYTFDW 326
YLR+LF LF + +DY +DW
Sbjct: 302 DYLRKLFTDLFDRKGYMFDYEYDW 325
>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
Length = 422
Score = 322 bits (826), Expect = 3e-88
Identities = 166/326 (50%), Positives = 217/326 (66%), Gaps = 27/326 (8%)
Query: 2 ASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYES 61
+ SS S +VG +++ +KIG G+FG++ L N+ E VA+KLE K+R PQL E
Sbjct: 29 SGSSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEY 88
Query: 62 KLYKIL-QGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
+ YK L G G+P + ++G YN +V++LLGPSLEDLF+ C R FT+KTVLM+A Q+
Sbjct: 89 RFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQL 148
Query: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ 180
+SR+EYVH+KN I+RD+KP+NFL IGR NK +
Sbjct: 149 LSRMEYVHSKNLIYRDVKPENFL--IGRQGNK------------------------KEHV 182
Query: 181 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 240
+ +IDFGLAK+Y D T++HIPYRE K+LTGTARY SIN HLG EQSRRDD+E+LG++ M
Sbjct: 183 IHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFM 242
Query: 241 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 300
YF R SLPWQGLKA T K++Y+KI + K +TP+E LC+ FP E A YL Y R L F E P
Sbjct: 243 YFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKP 302
Query: 301 DYMYLRQLFRILFRTLNHQYDYTFDW 326
DY YLR LF LF + +DY +DW
Sbjct: 303 DYEYLRTLFTDLFEKKGYTFDYAYDW 328
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 161 bits (407), Expect = 1e-39
Identities = 115/355 (32%), Positives = 170/355 (47%), Gaps = 51/355 (14%)
Query: 9 AEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQ 68
A ++V ++K+++KIG G FG+IY A+++ E VA+K+ES + L E + K LQ
Sbjct: 26 ANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQ 85
Query: 69 GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYV 127
G + G+ + +N +VM L G +L DL R FT+ T L L Q++ IE +
Sbjct: 86 GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 145
Query: 128 HTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFG 187
H+ F+HRDIKP NF MG P RK +++DFG
Sbjct: 146 HSVGFLHRDIKPSNFAMG---------RLPSTYRK------------------CYMLDFG 178
Query: 188 LAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSL 247
LA++Y N T P R GT RYAS+NAH E R DD+ SL Y+L+ F L
Sbjct: 179 LARQY-TNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQL 237
Query: 248 PWQGLKAATK----KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYM 303
PW+ +K + K+KYE +L K P+EF ++L++ L + PDY
Sbjct: 238 PWRKIKDKEQVGMIKEKYEH----------RMLLKHMPSEFHLFLDHIASLDYFTKPDYQ 287
Query: 304 YLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKT 358
+ +F + + FDW +KA A S+ TP + T +T
Sbjct: 288 LIMSVFENSMKERGIAENEAFDW----EKAGTDALLST----STSTPPQQNTRQT 334
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 155 bits (391), Expect = 7e-38
Identities = 106/317 (33%), Positives = 153/317 (48%), Gaps = 37/317 (11%)
Query: 12 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV 71
+V ++K++RKIG G FG+IY A+++ E VA+K+ES + L E + K LQG
Sbjct: 16 LVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD 75
Query: 72 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYVHTK 130
+ G+ +N +VM L G +L DL SR FT+ T L L Q++ IE +H+
Sbjct: 76 HVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSV 135
Query: 131 NFIHRDIKPDNFLMG-IGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLA 189
F+HRDIKP NF MG C KC +++DFGLA
Sbjct: 136 GFLHRDIKPSNFAMGRFPSTCRKC----------------------------YMLDFGLA 167
Query: 190 KKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 249
+++ N P R GT RYASINAH E R DD+ SL Y+L+ F LPW
Sbjct: 168 RQFT-NSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPW 226
Query: 250 QGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLF 309
+ +K E++ K ++ K P EF+++L++ L + PDY L +F
Sbjct: 227 RKIK------DKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVF 280
Query: 310 RILFRTLNHQYDYTFDW 326
+T FDW
Sbjct: 281 DNSIKTFGVIESDPFDW 297
>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
Length = 396
Score = 108 bits (269), Expect = 1e-23
Identities = 90/343 (26%), Positives = 154/343 (44%), Gaps = 61/343 (17%)
Query: 16 KYKLVRKIGSGSFGDIYLAINITNGEEVA------VKLES-------------QKARHPQ 56
++K+ IG G FG IYLA ++ + E V VK+E Q+A P+
Sbjct: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94
Query: 57 LLYESKLYKILQGGVGIPHIRWYGQE----KDYNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+ + + L+ +G+P G K Y ++MD G L+ ++ ++RF+ KT
Sbjct: 95 QIQKWIRTRKLKY-LGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153
Query: 113 VLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQD 172
VL L+ +++ +EY+H ++H DIK N L+
Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLL---------------------------- 185
Query: 173 PSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLT--GTARYASINAHLGIEQSRRD 230
++ +Q++L+D+GLA +Y H Y+ED GT + SI+AH G+ SRR
Sbjct: 186 -NYKNPDQVYLVDYGLAYRYCPEGV--HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG 242
Query: 231 DMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC---KGFPAEFAMY 287
D+E LGY ++ + LPW+ K + KI ++ + C K P E A Y
Sbjct: 243 DLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY 302
Query: 288 LNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLK 330
+ + L + E P Y LR + + + + D D ++++
Sbjct: 303 METVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVE 345
>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
Length = 396
Score = 104 bits (259), Expect = 1e-22
Identities = 90/327 (27%), Positives = 141/327 (43%), Gaps = 56/327 (17%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS 164
+ F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG------------------- 175
Query: 165 MTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI 224
+ +Q++L D+GL+ +Y N + K GT + S++AH G+
Sbjct: 176 ----------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGV 225
Query: 225 EQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFP 281
SRR D+E LGY ++ + LPW Q LK A + K + E S
Sbjct: 226 ALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSC 285
Query: 282 AEFAMYLNYCRGLRFEEAPDYMYLRQL 308
E A +L L ++E P+Y L+++
Sbjct: 286 CEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 104 bits (259), Expect = 1e-22
Identities = 90/327 (27%), Positives = 141/327 (43%), Gaps = 56/327 (17%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS 164
+ F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG------------------- 175
Query: 165 MTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI 224
+ +Q++L D+GL+ +Y N + K GT + S++AH G+
Sbjct: 176 ----------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGV 225
Query: 225 EQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFP 281
SRR D+E LGY ++ + LPW Q LK A + K + E S
Sbjct: 226 ALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSC 285
Query: 282 AEFAMYLNYCRGLRFEEAPDYMYLRQL 308
E A +L L ++E P+Y L+++
Sbjct: 286 CEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 104 bits (259), Expect = 1e-22
Identities = 90/327 (27%), Positives = 141/327 (43%), Gaps = 56/327 (17%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS 164
+ F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG------------------- 175
Query: 165 MTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI 224
+ +Q++L D+GL+ +Y N + K GT + S++AH G+
Sbjct: 176 ----------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGV 225
Query: 225 EQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFP 281
SRR D+E LGY ++ + LPW Q LK A + K + E S
Sbjct: 226 ALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSC 285
Query: 282 AEFAMYLNYCRGLRFEEAPDYMYLRQL 308
E A +L L ++E P+Y L+++
Sbjct: 286 CEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 104 bits (259), Expect = 1e-22
Identities = 90/327 (27%), Positives = 141/327 (43%), Gaps = 56/327 (17%)
Query: 6 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESK 62
G + + G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K
Sbjct: 18 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELK 75
Query: 63 LYKILQGG--------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFC 104
Y+ + +GIP G + + Y +VM+ LG L+ +
Sbjct: 76 FYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ- 134
Query: 105 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRS 164
+ F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 135 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG------------------- 175
Query: 165 MTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGI 224
+ +Q++L D+GL+ +Y N + K GT + S++AH G+
Sbjct: 176 ----------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGV 225
Query: 225 EQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFP 281
SRR D+E LGY ++ + LPW Q LK A + K + E S
Sbjct: 226 ALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSC 285
Query: 282 AEFAMYLNYCRGLRFEEAPDYMYLRQL 308
E A +L L ++E P+Y L+++
Sbjct: 286 CEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
Length = 485
Score = 103 bits (258), Expect = 2e-22
Identities = 89/319 (27%), Positives = 138/319 (43%), Gaps = 56/319 (17%)
Query: 14 GGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESKLYKILQGG 70
G ++ L +KIGSG FG IYLA E+ A VK+E Q+ + L E K Y+ +
Sbjct: 3 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 60
Query: 71 --------------VGIPHIRWYG----QEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+GIP G + + Y +VM+ LG L+ + + F T
Sbjct: 61 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 119
Query: 113 VLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQD 172
VL L +M+ +EY+H ++H DIK N L+G
Sbjct: 120 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG--------------------------- 152
Query: 173 PSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDM 232
+ +Q++L D+GL+ +Y N + K GT + S++AH G+ SRR D+
Sbjct: 153 --YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDV 210
Query: 233 ESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLN 289
E LGY ++ + LPW Q LK A + K + E S E A +L
Sbjct: 211 EILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLV 270
Query: 290 YCRGLRFEEAPDYMYLRQL 308
L ++E P+Y L+++
Sbjct: 271 CAHSLAYDEKPNYQALKKI 289
>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
Length = 390
Score = 85.9 bits (211), Expect = 5e-17
Identities = 61/224 (27%), Positives = 98/224 (43%), Gaps = 33/224 (14%)
Query: 88 LVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIG 147
+VM+ LG L+ + + F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 1 MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG-- 57
Query: 148 RHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDK 207
+ +Q++L D+GL+ +Y N + K
Sbjct: 58 ---------------------------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRK 90
Query: 208 NLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKI 264
GT + S++AH G+ SRR D+E LGY ++ + LPW Q LK A + K +
Sbjct: 91 GHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLL 150
Query: 265 SEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 308
E S E A +L L ++E P+Y L+++
Sbjct: 151 DELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 194
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 63.2 bits (152), Expect = 4e-10
Identities = 40/135 (29%), Positives = 71/135 (52%), Gaps = 7/135 (5%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIP 74
G Y+L+R IG G+F + LA +I G EVA+K+ + +P L KL++ ++ G+
Sbjct: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL--QKLFREVRIMKGLN 114
Query: 75 H---IRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLAD--QMISRIEYVHT 129
H ++ + + L + + S ++F++ MK A Q++S + Y H
Sbjct: 115 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 174
Query: 130 KNFIHRDIKPDNFLM 144
KN +HRD+K +N L+
Sbjct: 175 KNIVHRDLKAENLLL 189
>gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]
Length = 350
Score = 60.1 bits (144), Expect = 3e-09
Identities = 38/129 (29%), Positives = 68/129 (52%), Gaps = 4/129 (3%)
Query: 17 YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHI 76
Y+LVRK+G G + +++ AINITN E V VK+ + + ++ E K+ + L+GG I I
Sbjct: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI-LKPVKKKKIKREVKILENLRGGTNI--I 96
Query: 77 RWYGQEKDYNVLVMDLLGPSLEDL-FNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHR 135
+ KD L+ + + F + T + +++ ++Y H+K +HR
Sbjct: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHR 156
Query: 136 DIKPDNFLM 144
D+KP N ++
Sbjct: 157 DVKPHNVMI 165
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 58.5 bits (140), Expect = 9e-09
Identities = 38/134 (28%), Positives = 65/134 (48%), Gaps = 5/134 (3%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLM 144
+HRD+K +N L+
Sbjct: 173 RIVHRDLKAENLLL 186
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 58.5 bits (140), Expect = 9e-09
Identities = 38/134 (28%), Positives = 65/134 (48%), Gaps = 5/134 (3%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLM 144
+HRD+K +N L+
Sbjct: 173 RIVHRDLKAENLLL 186
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 58.5 bits (140), Expect = 9e-09
Identities = 38/134 (28%), Positives = 65/134 (48%), Gaps = 5/134 (3%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLM 144
+HRD+K +N L+
Sbjct: 173 RIVHRDLKAENLLL 186
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 58.5 bits (140), Expect = 9e-09
Identities = 38/134 (28%), Positives = 65/134 (48%), Gaps = 5/134 (3%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L++ IG G+F + LA +I G EVA+K+ + +P +L E ++ KIL
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFD-YLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 131 NFIHRDIKPDNFLM 144
+HRD+K +N L+
Sbjct: 173 RIVHRDLKAENLLL 186
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 56.2 bits (134), Expect = 4e-08
Identities = 38/134 (28%), Positives = 64/134 (47%), Gaps = 5/134 (3%)
Query: 15 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGG 70
G Y+L + IG G+F + LA ++ G EVAVK+ + +P +L E ++ KIL
Sbjct: 58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 117
Query: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130
+ EK +++ G + D + R K Q++S ++Y H K
Sbjct: 118 NIVKLFEVIETEKTLYLVMEYASGGEVFD-YLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176
Query: 131 NFIHRDIKPDNFLM 144
+HRD+K +N L+
Sbjct: 177 YIVHRDLKAENLLL 190
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 55.5 bits (132), Expect = 8e-08
Identities = 36/137 (26%), Positives = 70/137 (51%), Gaps = 8/137 (5%)
Query: 17 YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHI 76
+ ++ K+G GS+G +Y AI+ G+ VA+K ++ +++ E + + PH+
Sbjct: 30 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDS----PHV 85
Query: 77 -RWYGQE-KDYNV-LVMDLLGP-SLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132
++YG K+ ++ +VM+ G S+ D+ ++ T + + + +EY+H
Sbjct: 86 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 145
Query: 133 IHRDIKPDNFLMGIGRH 149
IHRDIK N L+ H
Sbjct: 146 IHRDIKAGNILLNTEGH 162
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,816,664
Number of Sequences: 37866
Number of extensions: 541002
Number of successful extensions: 2499
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 496
Number of HSP's successfully gapped in prelim test: 143
Number of HSP's that attempted gapping in prelim test: 1442
Number of HSP's gapped (non-prelim): 762
length of query: 365
length of database: 18,247,518
effective HSP length: 104
effective length of query: 261
effective length of database: 14,309,454
effective search space: 3734767494
effective search space used: 3734767494
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.