Guide to the Human Genome
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Search of human proteins with 67944634

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|67944634 exocyst complex component 1 isoform 1 [Homo
sapiens]
         (894 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|67944634 exocyst complex component 1 isoform 1 [Homo sapiens]     1762   0.0  
gi|30410720 exocyst complex component 1 isoform 1 [Homo sapiens]     1762   0.0  
gi|30410716 exocyst complex component 1 isoform 2 [Homo sapiens]     1722   0.0  
gi|21426793 amisyn [Homo sapiens]                                      86   1e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     54   5e-07
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       42   0.002
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       42   0.002
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        42   0.002
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        42   0.002
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s...    42   0.003
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s...    42   0.003
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]         42   0.003
gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens]         41   0.006
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       40   0.013
gi|33188443 microfilament and actin filament cross-linker protei...    40   0.013
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...    40   0.013
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    40   0.013
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        39   0.022
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        39   0.022
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         39   0.022
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         39   0.022
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         39   0.022
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         39   0.022
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         39   0.022
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         39   0.022
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    39   0.022
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    39   0.028
gi|38044112 restin isoform b [Homo sapiens]                            39   0.028
gi|4506751 restin isoform a [Homo sapiens]                             39   0.028
gi|71061468 centromere protein E [Homo sapiens]                        39   0.028

>gi|67944634 exocyst complex component 1 isoform 1 [Homo sapiens]
          Length = 894

 Score = 1762 bits (4563), Expect = 0.0
 Identities = 894/894 (100%), Positives = 894/894 (100%)

Query: 1   MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK 60
           MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK
Sbjct: 1   MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK 60

Query: 61  GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ 120
           GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ
Sbjct: 61  GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ 120

Query: 121 RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY 180
           RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY
Sbjct: 121 RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY 180

Query: 181 AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE 240
           AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE
Sbjct: 181 AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE 240

Query: 241 MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG 300
           MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG
Sbjct: 241 MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG 300

Query: 301 IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH 360
           IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH
Sbjct: 301 IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH 360

Query: 361 DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER 420
           DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER
Sbjct: 361 DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER 420

Query: 421 EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ 480
           EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ
Sbjct: 421 EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ 480

Query: 481 SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ 540
           SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ
Sbjct: 481 SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ 540

Query: 541 QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL 600
           QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL
Sbjct: 541 QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL 600

Query: 601 GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE 660
           GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE
Sbjct: 601 GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE 660

Query: 661 VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES 720
           VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES
Sbjct: 661 VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES 720

Query: 721 QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH 780
           QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH
Sbjct: 721 QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH 780

Query: 781 FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE 840
           FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE
Sbjct: 781 FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE 840

Query: 841 NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 894
           NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH
Sbjct: 841 NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 894


>gi|30410720 exocyst complex component 1 isoform 1 [Homo sapiens]
          Length = 894

 Score = 1762 bits (4563), Expect = 0.0
 Identities = 894/894 (100%), Positives = 894/894 (100%)

Query: 1   MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK 60
           MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK
Sbjct: 1   MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK 60

Query: 61  GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ 120
           GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ
Sbjct: 61  GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ 120

Query: 121 RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY 180
           RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY
Sbjct: 121 RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY 180

Query: 181 AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE 240
           AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE
Sbjct: 181 AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE 240

Query: 241 MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG 300
           MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG
Sbjct: 241 MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG 300

Query: 301 IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH 360
           IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH
Sbjct: 301 IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH 360

Query: 361 DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER 420
           DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER
Sbjct: 361 DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER 420

Query: 421 EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ 480
           EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ
Sbjct: 421 EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ 480

Query: 481 SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ 540
           SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ
Sbjct: 481 SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ 540

Query: 541 QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL 600
           QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL
Sbjct: 541 QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL 600

Query: 601 GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE 660
           GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE
Sbjct: 601 GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE 660

Query: 661 VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES 720
           VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES
Sbjct: 661 VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES 720

Query: 721 QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH 780
           QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH
Sbjct: 721 QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH 780

Query: 781 FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE 840
           FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE
Sbjct: 781 FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE 840

Query: 841 NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 894
           NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH
Sbjct: 841 NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 894


>gi|30410716 exocyst complex component 1 isoform 2 [Homo sapiens]
          Length = 879

 Score = 1722 bits (4461), Expect = 0.0
 Identities = 878/894 (98%), Positives = 878/894 (98%), Gaps = 15/894 (1%)

Query: 1   MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK 60
           MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK
Sbjct: 1   MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDK 60

Query: 61  GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ 120
           GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ
Sbjct: 61  GDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQ 120

Query: 121 RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY 180
           RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY
Sbjct: 121 RYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEY 180

Query: 181 AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE 240
           AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE
Sbjct: 181 AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEE 240

Query: 241 MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG 300
           MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG
Sbjct: 241 MLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRG 300

Query: 301 IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH 360
           IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH
Sbjct: 301 IEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGH 360

Query: 361 DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER 420
           DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER
Sbjct: 361 DQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER 420

Query: 421 EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQ 480
           EIKDFFEVAKIKMTGTTKESKKF                LHGSSGKLTGSTSSLNKLSVQ
Sbjct: 421 EIKDFFEVAKIKMTGTTKESKKF---------------GLHGSSGKLTGSTSSLNKLSVQ 465

Query: 481 SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ 540
           SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ
Sbjct: 466 SSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ 525

Query: 541 QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL 600
           QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL
Sbjct: 526 QHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIAL 585

Query: 601 GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE 660
           GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE
Sbjct: 586 GDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE 645

Query: 661 VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES 720
           VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES
Sbjct: 646 VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANES 705

Query: 721 QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH 780
           QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH
Sbjct: 706 QKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNH 765

Query: 781 FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE 840
           FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE
Sbjct: 766 FFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEE 825

Query: 841 NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 894
           NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH
Sbjct: 826 NLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 879


>gi|21426793 amisyn [Homo sapiens]
          Length = 210

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 65/200 (32%), Positives = 100/200 (50%), Gaps = 18/200 (9%)

Query: 5   KHALQRDIFTPNDERLLSIVNVCKAGKKKKN-----------CFLCATVTTERPVQVKVV 53
           K A+ ++IF P DER+L  V V +  KKK              ++C +VT ++P Q  + 
Sbjct: 4   KSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQASIT 63

Query: 54  KVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIY-KWVASSTAEKNAFI 112
           KVK+ +    + R+  W L  L  V+  D   ++ EFDL FE  + +WVAS+ +EK  F 
Sbjct: 64  KVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNGDSAEFDLLFENAFDQWVASTASEKCTFF 123

Query: 113 SCIWKLNQRYLR-KKIDFVNVSSQLL-EESVPSGENQSVTGGDEEVVDEYQELNAREEQD 170
             +    QRYL  +K +F+N  S+++   S+      SVT     V    Q LN R E+ 
Sbjct: 124 QILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSA---VQKASQALNERGER- 179

Query: 171 IEIMMEGCEYAISNAEAFAE 190
           +    E  E   ++A+ FAE
Sbjct: 180 LGRAEEKTEDLKNSAQQFAE 199


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 147/719 (20%), Positives = 287/719 (39%), Gaps = 91/719 (12%)

Query: 154 EEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQ 213
           ++ V   + L  R ++ I+   E C    S  EA  E+L   LQ L+   I+ +  +EK 
Sbjct: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE--KIKDLHMAEKT 342

Query: 214 VNILMKLLDEALKEVDQIE-----LKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVK 268
              L+  L +A   ++Q+E     +   +  +M ++++ + ++I++    I    T   +
Sbjct: 343 K--LITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400

Query: 269 LLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALRPGHDLLLA 328
           L  + E         K    A +E + A S   +    A   L   M+  ++      + 
Sbjct: 401 LREQKE---------KSERAAFEELEKALSTA-QKTEEARRKLKAEMDEQIKT-----IE 445

Query: 329 VKQQQQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQ-HSVELTLPNHHPFHRDLLR 387
              +++R S  +EL   R+   + +V  +   +Q + L + H  EL         +   R
Sbjct: 446 KTSEEERISLQQEL--SRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503

Query: 388 YAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKIKMTGT---TKESKKFA 444
             +  E +K         L K+  +YL    E+E ++   + ++++      T+   K  
Sbjct: 504 EREFQEQMKVA-------LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLR 556

Query: 445 TLPRKESAVKQETESLHGSSGKLTGSTSSLNK-LSVQSSGNRRSQSSSLLDMGNMSASDL 503
            L ++    +     L  S  K      + +K L+V     +   +  +  M     ++L
Sbjct: 557 DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL 616

Query: 504 -------DVADRTKFDKIFEQVLSELEPL---CLAEQDFISKFFKLQQHQSMPGTMAEAE 553
                  D     K   + +Q  +E+E L   C  E++ + K  ++          A  E
Sbjct: 617 ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII-------FQAHIE 669

Query: 554 DLDGGTLSRQHNCGTPLP-VSSEKDMIRQMMIKIFRCIEPELNNLIALGDKIDSFNSLYM 612
           +++  TL +     T L  +SSE   +    +K    +E EL+ L    DK+       M
Sbjct: 670 EMNEKTLEKLDVKQTELESLSSELSEV----LKARHKLEEELSVLKDQTDKMKQELEAKM 725

Query: 613 LVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGIL 672
             + +HH    Q VD      + +    V+++R  +K + +QI Q+E + + ++ K    
Sbjct: 726 DEQKNHH---QQQVD------SIIKEHEVSIQRT-EKALKDQINQLE-LLLKERDK---- 770

Query: 673 PFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANESQKTPRDVVMMEN 732
             + E +      E+  K +E  G+L +A  KL   VF + +   +E  K   + +    
Sbjct: 771 -HLKEHQAHVENLEADIKRSE--GELQQASAKL--DVFQSYQSATHEQTKAYEEQLAQLQ 825

Query: 733 FHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIY--SLGQPLEKLNHFFEG------ 784
              +     R+ ++   AE +  K+     L ++ I    L Q LEK N   E       
Sbjct: 826 QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLT 885

Query: 785 --VEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDK-HLCEEE 840
              E+++  G +E+E + Q+   K+ +   ++E   KE++     L  K D  H+  EE
Sbjct: 886 QVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 37/159 (23%), Positives = 77/159 (48%), Gaps = 16/159 (10%)

Query: 137 LEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEK-LSRE 195
           ++E + + E  S    +EE +   QEL+  +++ +++M +  E  I+  +   EK L+R+
Sbjct: 437 MDEQIKTIEKTS----EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARK 492

Query: 196 LQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISES 255
            Q L     + +   E++    MK+   AL++     LK+S  +E  +S+   ++++   
Sbjct: 493 EQEL----TKKLQTREREFQEQMKV---ALEKSQSEYLKISQEKEQQESL--ALEELELQ 543

Query: 256 NHLIHLSNTNNVK-LLSEIE-FLVNHMDLAKGHIKALQE 292
              I   + N ++ L  E E +    ++L     K+LQE
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 67/320 (20%), Positives = 143/320 (44%), Gaps = 53/320 (16%)

Query: 81  KDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEES 140
           K  +KE  +  +  E++ +W  S   E+ A +    K  ++  ++ ++      + +EE 
Sbjct: 108 KAKLKELEKHKIQLEQVQEW-KSKMQEQQADLQRRLKEARKEAKEALE---AKERYMEEM 163

Query: 141 VPSGENQSVTGGDEEVVDE-----YQELNAREEQ------DIEIMMEGCEYAISNAEAFA 189
             + +   +   D+E+ +E      QE+ A +E+      D+EI+    E   S+  A +
Sbjct: 164 ADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 223

Query: 190 EKLSR----ELQVLDG-ANIQSIMASEKQVNI-LMKLLDEALKEVD-------QIELKLS 236
            +L +      ++ D    ++ + +SEKQ ++ L KL+++  +E++       +++ +LS
Sbjct: 224 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELS 283

Query: 237 SYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLA 296
             E  +  +KEQ+D    +  ++ +    N+ L    E  V  +    G ++A+ E    
Sbjct: 284 QAESTIDELKEQVDAALGAEEMVEMLTDRNLNL----EEKVRELRETVGDLEAMNE---- 335

Query: 297 SSRGIEACTNAADALLQCMNVALRPGHDLLLA-VKQQQQRFSDLRELFA---------RR 346
                E   NA +  L+     LR   D+  A V++ Q+R    +E  A         R+
Sbjct: 336 --MNDELQENARETELE-----LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQ 388

Query: 347 LASHLNNVFVQQGHDQSSTL 366
           L +HL +V  +  + Q +++
Sbjct: 389 LTAHLQDVNRELTNQQEASV 408


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 67/320 (20%), Positives = 143/320 (44%), Gaps = 53/320 (16%)

Query: 81  KDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEES 140
           K  +KE  +  +  E++ +W  S   E+ A +    K  ++  ++ ++      + +EE 
Sbjct: 222 KAKLKELEKHKIQLEQVQEW-KSKMQEQQADLQRRLKEARKEAKEALE---AKERYMEEM 277

Query: 141 VPSGENQSVTGGDEEVVDE-----YQELNAREEQ------DIEIMMEGCEYAISNAEAFA 189
             + +   +   D+E+ +E      QE+ A +E+      D+EI+    E   S+  A +
Sbjct: 278 ADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 337

Query: 190 EKLSR----ELQVLDG-ANIQSIMASEKQVNI-LMKLLDEALKEVD-------QIELKLS 236
            +L +      ++ D    ++ + +SEKQ ++ L KL+++  +E++       +++ +LS
Sbjct: 338 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELS 397

Query: 237 SYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLA 296
             E  +  +KEQ+D    +  ++ +    N+ L    E  V  +    G ++A+ E    
Sbjct: 398 QAESTIDELKEQVDAALGAEEMVEMLTDRNLNL----EEKVRELRETVGDLEAMNE---- 449

Query: 297 SSRGIEACTNAADALLQCMNVALRPGHDLLLA-VKQQQQRFSDLRELFA---------RR 346
                E   NA +  L+     LR   D+  A V++ Q+R    +E  A         R+
Sbjct: 450 --MNDELQENARETELE-----LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQ 502

Query: 347 LASHLNNVFVQQGHDQSSTL 366
           L +HL +V  +  + Q +++
Sbjct: 503 LTAHLQDVNRELTNQQEASV 522


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 67/320 (20%), Positives = 143/320 (44%), Gaps = 53/320 (16%)

Query: 81  KDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEES 140
           K  +KE  +  +  E++ +W  S   E+ A +    K  ++  ++ ++      + +EE 
Sbjct: 108 KAKLKELEKHKIQLEQVQEW-KSKMQEQQADLQRRLKEARKEAKEALE---AKERYMEEM 163

Query: 141 VPSGENQSVTGGDEEVVDE-----YQELNAREEQ------DIEIMMEGCEYAISNAEAFA 189
             + +   +   D+E+ +E      QE+ A +E+      D+EI+    E   S+  A +
Sbjct: 164 ADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 223

Query: 190 EKLSR----ELQVLDG-ANIQSIMASEKQVNI-LMKLLDEALKEVD-------QIELKLS 236
            +L +      ++ D    ++ + +SEKQ ++ L KL+++  +E++       +++ +LS
Sbjct: 224 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELS 283

Query: 237 SYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLA 296
             E  +  +KEQ+D    +  ++ +    N+ L    E  V  +    G ++A+ E    
Sbjct: 284 QAESTIDELKEQVDAALGAEEMVEMLTDRNLNL----EEKVRELRETVGDLEAMNE---- 335

Query: 297 SSRGIEACTNAADALLQCMNVALRPGHDLLLA-VKQQQQRFSDLRELFA---------RR 346
                E   NA +  L+     LR   D+  A V++ Q+R    +E  A         R+
Sbjct: 336 --MNDELQENARETELE-----LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQ 388

Query: 347 LASHLNNVFVQQGHDQSSTL 366
           L +HL +V  +  + Q +++
Sbjct: 389 LTAHLQDVNRELTNQQEASV 408


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 67/320 (20%), Positives = 143/320 (44%), Gaps = 53/320 (16%)

Query: 81  KDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEES 140
           K  +KE  +  +  E++ +W  S   E+ A +    K  ++  ++ ++      + +EE 
Sbjct: 242 KAKLKELEKHKIQLEQVQEW-KSKMQEQQADLQRRLKEARKEAKEALE---AKERYMEEM 297

Query: 141 VPSGENQSVTGGDEEVVDE-----YQELNAREEQ------DIEIMMEGCEYAISNAEAFA 189
             + +   +   D+E+ +E      QE+ A +E+      D+EI+    E   S+  A +
Sbjct: 298 ADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 357

Query: 190 EKLSR----ELQVLDG-ANIQSIMASEKQVNI-LMKLLDEALKEVD-------QIELKLS 236
            +L +      ++ D    ++ + +SEKQ ++ L KL+++  +E++       +++ +LS
Sbjct: 358 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELS 417

Query: 237 SYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLA 296
             E  +  +KEQ+D    +  ++ +    N+ L    E  V  +    G ++A+ E    
Sbjct: 418 QAESTIDELKEQVDAALGAEEMVEMLTDRNLNL----EEKVRELRETVGDLEAMNE---- 469

Query: 297 SSRGIEACTNAADALLQCMNVALRPGHDLLLA-VKQQQQRFSDLRELFA---------RR 346
                E   NA +  L+     LR   D+  A V++ Q+R    +E  A         R+
Sbjct: 470 --MNDELQENARETELE-----LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQ 522

Query: 347 LASHLNNVFVQQGHDQSSTL 366
           L +HL +V  +  + Q +++
Sbjct: 523 LTAHLQDVNRELTNQQEASV 542


>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
           sapiens]
          Length = 1719

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 59/287 (20%), Positives = 125/287 (43%), Gaps = 43/287 (14%)

Query: 28  KAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIA-----WALRDLAVVDAKD 82
           K   +KK+ F    ++    +    +K  K +  D   +Q+A       L+D      ++
Sbjct: 690 KTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRE 749

Query: 83  AIKENPEFDLHFEKIYKWVASSTAEKNAFISC-IWKLNQRYLRKKIDFVNVSSQLLEESV 141
           +  E  EF+  F++ Y+       E+N  ++  + KL   Y     + +++ +Q LEE V
Sbjct: 750 SQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLY-----ENLSIHNQQLEEEV 804

Query: 142 P--SGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVL 199
              + + +SV   + ++ +  Q ++  +E+D          A    +A A K++ EL+ L
Sbjct: 805 KDLADKKESVAHWEAQITEIIQWVS--DEKD----------ARGYLQALASKMTEELEAL 852

Query: 200 DGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLI 259
             +++ +              LD + +   +++  L +     Q+++E+++++  SN + 
Sbjct: 853 RNSSLGTRATDMPWKMRRFAKLDMSARL--ELQSALDAEIRAKQAIQEELNKVKASNIIT 910

Query: 260 HL----SNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIE 302
                 S   N++LLSEIE L+   +            +L S +GIE
Sbjct: 911 ECKLKDSEKKNLELLSEIEQLIKDTE------------ELRSEKGIE 945



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 68/334 (20%), Positives = 128/334 (38%), Gaps = 42/334 (12%)

Query: 183 SNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEML 242
           S+ E   E+ +   Q LD A  + I A EKQ+  L +  ++  KE+ Q   +L +  + L
Sbjct: 507 SHLEQQLEEANAVRQELDDA-FRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKEL 565

Query: 243 QSV----KEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASS 298
           +      K  M +  E N  +   +T   KL   +      +DL    +++L++    + 
Sbjct: 566 KDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTE 625

Query: 299 RGIEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQ 358
           R                   L    + L A   + ++  +  E ++++L + L  +  +Q
Sbjct: 626 RA---------------KKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQ 670

Query: 359 -GHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSR- 416
             +       +H  E+T         DL + +   E     +  K EG+  N +  L + 
Sbjct: 671 ISYSPGVCSIEHQQEIT-----KLKTDLEKKSIFYE----EELSKREGIHANEIKNLKKE 721

Query: 417 LYERE-----IKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETES----LHGSSGKL 467
           L++ E     +     + K K+  T +ES+  +     ES  KQ+ E     L   + KL
Sbjct: 722 LHDSEGQQLALNKEIMILKDKLEKTRRESQ--SEREEFESEFKQQYEREKVLLTEENKKL 779

Query: 468 TGSTSSLNKLSVQSSGNRRSQSSSLLDMGNMSAS 501
           T     L  L    S + +     + D+ +   S
Sbjct: 780 TSELDKLTTLYENLSIHNQQLEEEVKDLADKKES 813


>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
           sapiens]
          Length = 1638

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 59/287 (20%), Positives = 125/287 (43%), Gaps = 43/287 (14%)

Query: 28  KAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIA-----WALRDLAVVDAKD 82
           K   +KK+ F    ++    +    +K  K +  D   +Q+A       L+D      ++
Sbjct: 609 KTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRE 668

Query: 83  AIKENPEFDLHFEKIYKWVASSTAEKNAFISC-IWKLNQRYLRKKIDFVNVSSQLLEESV 141
           +  E  EF+  F++ Y+       E+N  ++  + KL   Y     + +++ +Q LEE V
Sbjct: 669 SQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLY-----ENLSIHNQQLEEEV 723

Query: 142 P--SGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVL 199
              + + +SV   + ++ +  Q ++  +E+D          A    +A A K++ EL+ L
Sbjct: 724 KDLADKKESVAHWEAQITEIIQWVS--DEKD----------ARGYLQALASKMTEELEAL 771

Query: 200 DGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLI 259
             +++ +              LD + +   +++  L +     Q+++E+++++  SN + 
Sbjct: 772 RNSSLGTRATDMPWKMRRFAKLDMSARL--ELQSALDAEIRAKQAIQEELNKVKASNIIT 829

Query: 260 HL----SNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIE 302
                 S   N++LLSEIE L+   +            +L S +GIE
Sbjct: 830 ECKLKDSEKKNLELLSEIEQLIKDTE------------ELRSEKGIE 864


>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
          Length = 284

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 54/265 (20%), Positives = 113/265 (42%), Gaps = 32/265 (12%)

Query: 133 SSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKL 192
           S QL +E V     Q    G E+ +D+Y E     ++ +E+     E   ++AEA    L
Sbjct: 36  SKQLEDELVSL---QKKLKGTEDELDKYSEALKDAQEKLEL----AEKKATDAEADVASL 88

Query: 193 SRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMD-- 250
           +R +Q+++    + +  +++++   ++ L+EA K  D+ E  +   E   Q  +E+M+  
Sbjct: 89  NRRIQLVE----EELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQ 144

Query: 251 --QISESNHLIHLSNTNN-------VKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGI 301
             Q+ E+ H+   ++          V + S++E      +L++G    L+E     +  +
Sbjct: 145 EIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNL 204

Query: 302 EACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGHD 361
           ++    A+   Q         ++  + V   + + ++ R  FA R  + L     ++  D
Sbjct: 205 KSLEAQAEKYSQ-----KEDRYEEEIKVLSDKLKEAETRAEFAERSVTKL-----EKSID 254

Query: 362 QSSTLAQHSVELTLPNHHPFHRDLL 386
                  H+ E  L  H    + LL
Sbjct: 255 DLEEKVAHAKEENLSMHQMLDQTLL 279


>gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens]
          Length = 284

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 39/171 (22%), Positives = 81/171 (47%), Gaps = 22/171 (12%)

Query: 133 SSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKL 192
           S QL +E V     Q    G E+ +D+Y E     ++ +E+     E   ++AEA    L
Sbjct: 36  SKQLEDELVSL---QKKLKGTEDELDKYSEALKDAQEKLEL----AEKKATDAEADVASL 88

Query: 193 SRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMD-- 250
           +R +Q+++    + +  +++++   ++ L+EA K  D+ E  +   E   Q  +E+M+  
Sbjct: 89  NRRIQLVE----EELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQ 144

Query: 251 --QISESNHLIHLSNTNN-------VKLLSEIEFLVNHMDLAKGHIKALQE 292
             Q+ E+ H+   ++          V + S++E      +L++G    L+E
Sbjct: 145 EIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEE 195


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 134/694 (19%), Positives = 262/694 (37%), Gaps = 112/694 (16%)

Query: 211  EKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIH--LSNTNNV- 267
            EK+ N+    +  + +E  Q+++K     E +++   ++  + + N ++   +SNT N  
Sbjct: 384  EKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA---EIAHLKQENGILRDAVSNTTNQL 440

Query: 268  ---------KLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVA 318
                     KL  +   LVN +    G    LQ+ ++      +A T             
Sbjct: 441  ESKQSAELNKLRQDYARLVNELTEKTGK---LQQEEVQKKNAEQAATQ------------ 485

Query: 319  LRPGHDLLLAVKQQQQRFSDLRELFARRLASH------LNNVFVQQGHDQSSTLAQHSVE 372
                  L + +++ ++R+ +++    +R A H      L + FV + ++  S  ++  + 
Sbjct: 486  ------LKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK--LT 537

Query: 373  LTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSR--LYEREIKDFFEVAK 430
             TL +     + L++   LME  +     K E L     D L +    + +I+ F     
Sbjct: 538  DTLVSKQQLEQRLMQ---LME-SEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593

Query: 431  IKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGNRRSQSS 490
             + + +    +    +  K+  +KQ  +SL     +LT     L  +    +   +++  
Sbjct: 594  AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQ-NMNFLLKAEVQ 652

Query: 491  SLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQSMPGTMA 550
             L  + N  A     A   + +K+ + V  + + + L E+          QH+ +   M 
Sbjct: 653  KLQALANEQA-----AAAHELEKMQQSVYVKDDKIRLLEEQL--------QHE-ISNKME 698

Query: 551  E---AEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKI------FRCIEPEL-NNLIAL 600
            E     D +    S      T +     KD++ QM   I       + +E  L   LI +
Sbjct: 699  EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758

Query: 601  GDKIDSFNSL----YMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISN--Q 654
              K +  N++      L K    +   QN D  SF S  L   L  V    D  I +  +
Sbjct: 759  ATKEEELNAIRTENSSLTKEVQDLKAKQN-DQVSFAS--LVEELKKVIHEKDGKIKSVEE 815

Query: 655  IRQMEEVKISKKSKVGILPFVAEFEEFAGLAE------SIFKNAERRGDLDKAYT----- 703
            + + E +K++ K K   L   ++ +E   L +      +  K      + D A T     
Sbjct: 816  LLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ 875

Query: 704  ---KLIRGVFVNVEKVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYT 760
               +    +  +V++VA  + K        E    +       ++  LEA  KE +   +
Sbjct: 876  DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN-ELKRLEAMLKERESDLS 934

Query: 761  DHLQSYVIYSLGQPLEKLNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKE 820
               Q      L Q ++  N  F+    ++ Q   ++  S+      +EL KVI E   KE
Sbjct: 935  SKTQ------LLQDVQDENKLFKSQIEQLKQQNYQQASSFP---PHEELLKVISERE-KE 984

Query: 821  VK---KGLDNLYKKVDKHLCEEENLLQVVWHSMQ 851
            +      LD+L   V+    +  +L +  W +M+
Sbjct: 985  ISGLWNELDSLKDAVEHQRKKNNDLREKNWEAME 1018



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 27/132 (20%), Positives = 64/132 (48%), Gaps = 10/132 (7%)

Query: 169 QDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEV 228
           + +E ++E     ++N E   + LS   +V +  N+  +   E+Q+N +  +L+E  K++
Sbjct: 811 KSVEELLEAELLKVANKEKTVQ-LSITSKVQELQNL--LKGKEEQMNTMKAVLEEKEKDL 867

Query: 229 DQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIK 288
                 L   +E  +S+K  + ++++ N    L   ++     E+E ++   +     ++
Sbjct: 868 ANTGKWLQDLQEENESLKAHVQEVAQHN----LKEASSASQFEELEIVLKEKENELKRLE 923

Query: 289 AL---QEGDLAS 297
           A+   +E DL+S
Sbjct: 924 AMLKERESDLSS 935



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 58/282 (20%), Positives = 119/282 (42%), Gaps = 51/282 (18%)

Query: 17   DERLLSIVNVCKAG-----KKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWA 71
            DE+L ++  + + G      K++      T  +    +V+ +K K++D+  F     A  
Sbjct: 741  DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSF-----ASL 795

Query: 72   LRDLA-VVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLN--QRYLRKKID 128
            + +L  V+  KD   ++ E  L  E +      +  EK   +S   K+   Q  L+ K +
Sbjct: 796  VEELKKVIHEKDGKIKSVEELLEAELL----KVANKEKTVQLSITSKVQELQNLLKGKEE 851

Query: 129  FVNVSSQLLEESVPS------------GENQSVTGGDEEVVDEY--QELNAREEQDIEIM 174
             +N    +LEE                 EN+S+    +EV      +  +A + +++EI+
Sbjct: 852  QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 911

Query: 175  MEGCEYAISNAEAFAEK----LSRELQVLDGAN-----IQSIMASEKQVNI--------- 216
            ++  E  +   EA  ++    LS + Q+L          +S +   KQ N          
Sbjct: 912  LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 971

Query: 217  --LMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESN 256
              L+K++ E  KE+  +  +L S ++ ++  +++ + + E N
Sbjct: 972  EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKN 1013


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 73/340 (21%), Positives = 135/340 (39%), Gaps = 65/340 (19%)

Query: 227  EVDQIELKLSSYEEMLQSVKEQMDQISE---------SNHLIHLS---NTNNVKLLSE-- 272
            +VD + L L  YE++ Q + E+  Q+           S H   LS   N   ++LL+E  
Sbjct: 1955 DVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQ 2014

Query: 273  ------IEFLVNHMDLAKGHIKALQEGDLASS--RGIEACTNAADALLQCMNVALR--PG 322
                  +E     +D  +GH++ +++  L  +  +    C    + L   +  A R   G
Sbjct: 2015 RSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAG 2074

Query: 323  H------DLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLP 376
            H        L A+++ Q    DL++    R  S     F     D    + ++  +L+ P
Sbjct: 2075 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATS-----FATVVKDIEGFMEENQTKLS-P 2128

Query: 377  NHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKIKMTGT 436
                  R+ L  AK           +YE L +      +R+ ++E+++    A  + T  
Sbjct: 2129 RELTALREKLHQAK----------EQYEALQEE-----TRVAQKELEEAVTSALQQETEK 2173

Query: 437  TKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGNRRSQSSSLLDMG 496
            +K +K+ A   +K  A+     S+  S G+L  +   + +LS  S           L+ G
Sbjct: 2174 SKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS-----------LEKG 2222

Query: 497  NMSASDLDVADR---TKFDKIFEQVLSELEPLCLAEQDFI 533
             +  +D  +       K DK  E + +  + L   +Q+FI
Sbjct: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFI 2262


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 64/337 (18%), Positives = 136/337 (40%), Gaps = 60/337 (17%)

Query: 155  EVVDEYQELNAREEQD---IEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASE 211
            E + + +   A +EQ    ++++   C+ + ++ +  A+ + +  Q ++   +Q+   ++
Sbjct: 4000 EAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ 4059

Query: 212  --KQVNILMKLLDEALKEVDQ---------IELKLSSYEEMLQSVKEQMDQISES----N 256
              +++  L   L   L++ DQ          EL+L+  + M+  VK+ + ++       N
Sbjct: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119

Query: 257  HLIHLSNTNNVKLLSEIEFLVNHM-----DLAK--GHIKALQEGDLASSRGIEACTNAAD 309
             +I   N    K  S     +NH+     DL +   ++   +E DL  +R    C N  +
Sbjct: 4120 TIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVE 4179

Query: 310  ALLQCMN---------------VALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLN-- 352
              L+                  V L     L LA+++++    DL++   +++  HLN  
Sbjct: 4180 VFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQ-KQKMIEHLNLD 4238

Query: 353  --------NVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYE 404
                       ++Q   Q   L +  +++++ N    +    R+ +LMEW +       E
Sbjct: 4239 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4298

Query: 405  GLTKN---------YMDYLSRLYEREIKDFFEVAKIK 432
             L ++          MD+L+   E E K     + IK
Sbjct: 4299 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIK 4335



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 55/278 (19%), Positives = 109/278 (39%), Gaps = 50/278 (17%)

Query: 90   FDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEESVPSGENQSV 149
            F  +FE +  W+     E NA  +    ++ +  + K+    + S+L           S+
Sbjct: 1458 FGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKL----------SSI 1507

Query: 150  TGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMA 209
             G +EE     Q +   E   I+         ++    + E+L    Q L+G  +  +  
Sbjct: 1508 VGLEEEAQSFAQFVTTGESARIKA-------KLTQIRRYGEELREHAQCLEGTILGHLSQ 1560

Query: 210  SEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKL 269
             +K         +E L+++              QSV E  D+++    +   S T   K+
Sbjct: 1561 QQK--------FEENLRKIQ-------------QSVSEFEDKLAVPIKICS-SATETYKV 1598

Query: 270  LSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALRPGHDLLLAV 329
            L E      HMDL +  +++L     A S       N  D+ +Q      +   D+L   
Sbjct: 1599 LQE------HMDLCQA-LESLSSAITAFSASARKVVN-RDSCVQEAAALQQQYEDILRRA 1650

Query: 330  KQQQQRFSDLRELFARRLASHLNN--VFVQQGHDQSST 365
            K++Q    +L   + +RL   L++   ++++G  ++S+
Sbjct: 1651 KERQTALENLLAHW-QRLEKELSSFLTWLERGEAKASS 1687


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 39.7 bits (91), Expect = 0.013
 Identities = 64/337 (18%), Positives = 136/337 (40%), Gaps = 60/337 (17%)

Query: 155  EVVDEYQELNAREEQD---IEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASE 211
            E + + +   A +EQ    ++++   C+ + ++ +  A+ + +  Q ++   +Q+   ++
Sbjct: 4071 EAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ 4130

Query: 212  --KQVNILMKLLDEALKEVDQ---------IELKLSSYEEMLQSVKEQMDQISES----N 256
              +++  L   L   L++ DQ          EL+L+  + M+  VK+ + ++       N
Sbjct: 4131 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4190

Query: 257  HLIHLSNTNNVKLLSEIEFLVNHM-----DLAK--GHIKALQEGDLASSRGIEACTNAAD 309
             +I   N    K  S     +NH+     DL +   ++   +E DL  +R    C N  +
Sbjct: 4191 TIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVE 4250

Query: 310  ALLQCMN---------------VALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLN-- 352
              L+                  V L     L LA+++++    DL++   +++  HLN  
Sbjct: 4251 VFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQ-KQKMIEHLNLD 4309

Query: 353  --------NVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYE 404
                       ++Q   Q   L +  +++++ N    +    R+ +LMEW +       E
Sbjct: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369

Query: 405  GLTKN---------YMDYLSRLYEREIKDFFEVAKIK 432
             L ++          MD+L+   E E K     + IK
Sbjct: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIK 4406



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 104/543 (19%), Positives = 218/543 (40%), Gaps = 87/543 (16%)

Query: 116  WKLNQRYLRK-KIDFVNVSSQL-LEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEI 173
            W+  Q  L + +  F NV ++L L E      ++ +   +E+V    +  + R  ++I++
Sbjct: 3579 WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQL 3638

Query: 174  --MMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEK------------QVNILMK 219
              M +  E   +  +   E  +R  ++LD +++ S M  +             QV   +K
Sbjct: 3639 HQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIK 3698

Query: 220  LLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNH 279
             L+E ++ +++ E  LSSY +   S  +    +  +  +  +      K L  +E L+  
Sbjct: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNV--ATKIDKVDTVMMGKKLKTLEVLLK- 3755

Query: 280  MDLAKGH-------------IKALQEGDLASSRGIEACTNAADALLQCMNVALRPGHDLL 326
             D+ KGH             +K L+EG+    R  +   +  + L + +   +R  H  L
Sbjct: 3756 -DMEKGHSLLKSAREKGERAVKYLEEGEAERLR--KEIHDHMEQLKE-LTSTVRKEHMTL 3811

Query: 327  LAVKQQQQRFSDLRELFARRLASHLNNVFVQQG-----HDQSSTLAQH-SVELTLPNHHP 380
                   + FSD  +   + +A +   + V +      +++ + L+++ S++ T+ +H P
Sbjct: 3812 EKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEP 3871

Query: 381  FHRDLLRYAK-LMEWLK-----------STDY------GK-----YEGLTKNYMDYLSRL 417
              + +    + L+E ++            +DY      GK      E   K++ DY S L
Sbjct: 3872 SVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSEL 3931

Query: 418  YEREIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKL 477
             E E K   +++   +     E+    T+ ++ +  K   E + G   +L       + L
Sbjct: 3932 QEVE-KWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTL 3990

Query: 478  SVQSSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFF 537
              Q + + +++    +        D   A  +   ++++ +  EL       Q  +S+  
Sbjct: 3991 IGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL-------QKHVSRQD 4043

Query: 538  KLQQHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNL 597
             LQQ Q+     A   DL+           +P P  S  + I+Q  +K FR ++ +    
Sbjct: 4044 TLQQCQAW--LSAVQPDLE----------PSPQPPLSRAEAIKQ--VKHFRALQEQARTY 4089

Query: 598  IAL 600
            + L
Sbjct: 4090 LDL 4092



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 55/278 (19%), Positives = 109/278 (39%), Gaps = 50/278 (17%)

Query: 90   FDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEESVPSGENQSV 149
            F  +FE +  W+     E NA  +    ++ +  + K+    + S+L           S+
Sbjct: 1451 FGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKL----------SSI 1500

Query: 150  TGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMA 209
             G +EE     Q +   E   I+         ++    + E+L    Q L+G  +  +  
Sbjct: 1501 VGLEEEAQSFAQFVTTGESARIKA-------KLTQIRRYGEELREHAQCLEGTILGHLSQ 1553

Query: 210  SEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKL 269
             +K         +E L+++              QSV E  D+++    +   S T   K+
Sbjct: 1554 QQK--------FEENLRKIQ-------------QSVSEFEDKLAVPIKICS-SATETYKV 1591

Query: 270  LSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALRPGHDLLLAV 329
            L E      HMDL +  +++L     A S       N  D+ +Q      +   D+L   
Sbjct: 1592 LQE------HMDLCQA-LESLSSAITAFSASARKVVN-RDSCVQEAAALQQQYEDILRRA 1643

Query: 330  KQQQQRFSDLRELFARRLASHLNN--VFVQQGHDQSST 365
            K++Q    +L   + +RL   L++   ++++G  ++S+
Sbjct: 1644 KERQTALENLLAHW-QRLEKELSSFLTWLERGEAKASS 1680


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2389 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2500

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2621 AATKTLPN 2628


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2393 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2504

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2625 AATKTLPN 2632


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2389 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2500

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2621 AATKTLPN 2628


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2357 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2468

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2588

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2589 AATKTLPN 2596


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2526 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2637

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2757

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2758 AATKTLPN 2765


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2367 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2478

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2598

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2599 AATKTLPN 2606


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2375 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2427

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2486

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2606

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2607 AATKTLPN 2614


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 35/248 (14%)

Query: 157  VDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSR-ELQVLDGAN-IQSIMASEKQV 214
            V E     AR E+D +   +        AE   EKL R EL   +    +Q++    +Q 
Sbjct: 2416 VAEMSRAQARAEEDAQRFRK-------QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2468

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            +   + L EA+ E+++ + KL    ++LQ   E+M Q  +   L+  +       LSE +
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-QTVQQEQLLQETQALQQSFLSEKD 2527

Query: 275  FLVNH---MDLAKGHIKALQEGDLASSRGI--------EACTNAADALLQCMNVALRPGH 323
             L+     ++  K  ++ L + ++A ++ +        +        L+  M  A R  H
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587

Query: 324  DLLLAVKQQQQRFSDL-------RELFA---RRLASHLNNVFVQQ----GHDQSSTLAQH 369
            +    V+++Q+    L        EL A   +RL   L  +  Q      H +  T +Q 
Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2647

Query: 370  SVELTLPN 377
            +   TLPN
Sbjct: 2648 AATKTLPN 2655


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 93/498 (18%), Positives = 198/498 (39%), Gaps = 72/498 (14%)

Query: 120  QRYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQE-LNAREEQ------DIE 172
            ++ +++K+D +      LEE++  GE Q      ++ V + QE L++   Q       + 
Sbjct: 2138 KKNMQEKLDALRREKVHLEETI--GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195

Query: 173  IMMEGCEYAISNAEAFAEKLSRELQ---------------VLDGANIQSIMASEKQVNIL 217
             + +  +  I  A+ +  K S  +Q               + D     SI   E ++NI 
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS 2255

Query: 218  MKLLDEAL---KEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
                D+ +   K   +++L+    + +    KE + Q+ E+ HL H S     KL SE++
Sbjct: 2256 RLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK 2315

Query: 275  FLVNHM-DLA---------KGHIKAL---QEGDLASSR--------GIEACTNAADALLQ 313
             L + + DL+         KG+++ +   QE D+ +S+         ++A       L +
Sbjct: 2316 SLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHE 2375

Query: 314  CMNVALRPGHDLLLAVKQQ-QQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVE 372
             +N+  +    LL   ++  Q   ++LR+   + +   L N+  Q+  +      ++   
Sbjct: 2376 EINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI-KELENLLSQEEEENIVLEEENKKA 2434

Query: 373  LTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKIK 432
            +   N       L+   K ++        + +   K+ M  L    +R + D+ ++ +  
Sbjct: 2435 VDKTN------QLMETLKTIKKENIQQKAQLDSFVKS-MSSLQNDRDRIVGDYQQLEERH 2487

Query: 433  MTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGN-------R 485
            ++   ++ +       + + +K+E   L      L    + L+   +Q   +       +
Sbjct: 2488 LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIK 2547

Query: 486  RSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQSM 545
             SQ   LL++      +L+     K+ K+ E+ L E E    A +D    F  LQ+ +  
Sbjct: 2548 DSQQKQLLEVQLQQNKELE----NKYAKL-EEKLKESEE---ANEDLRRSFNALQEEKQD 2599

Query: 546  PGTMAEAEDLDGGTLSRQ 563
                 E+  +    L+RQ
Sbjct: 2600 LSKEIESLKVSISQLTRQ 2617



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 69/340 (20%), Positives = 134/340 (39%), Gaps = 42/340 (12%)

Query: 137 LEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSREL 196
           +E+   S E+QS T  +  + D   EL + ++          + ++S      +    EL
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDG--------DKSLSAVPDIGQCHQDEL 686

Query: 197 QVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESN 256
           + L    ++  +   K   I  K LDE  KE+  +   +  +++   +       +SE  
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746

Query: 257 HLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMN 316
             + LS    + +++E+   V  +++     +  +  D  S     A  N     +  ++
Sbjct: 747 DQL-LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQ---TAHDNLLTEQIHSLS 802

Query: 317 VALRPGHDLLLAVKQQ-----QQRFSDLRELFARRLASHLNN--VFVQQGHDQ------- 362
           +  +   D+ + V Q      Q +FS+   L  R L S L N    V +G ++       
Sbjct: 803 IEAK-SKDVKIEVLQNELDDVQLQFSEQSTLI-RSLQSQLQNKESEVLEGAERVRHISSK 860

Query: 363 ----SSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLY 418
               S  L+Q  +E+T        + LL   + +E L+ T   K + +T+       ++ 
Sbjct: 861 VEELSQALSQKELEIT-----KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMV 915

Query: 419 EREIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETE 458
           +   + F    +IK   T KE  +   L R E A K++ E
Sbjct: 916 QLNEEKFSLGVEIK---TLKE--QLNLLSRAEEAKKEQVE 950



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 69/316 (21%), Positives = 132/316 (41%), Gaps = 46/316 (14%)

Query: 62   DFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQR 121
            D  KR+   +L++LA +  +  +  N E D    +     + ++ E+N+ +S + KLNQ+
Sbjct: 2755 DELKRKYDASLKELAQLKEQGLL--NRERDALLSETA--FSMNSTEENS-LSHLEKLNQQ 2809

Query: 122  YLRKKIDFVNVSSQL---------LEESVPSGENQSVTGGDE----EVVDEYQELNAREE 168
             L K    +++SSQL           +++ S +N+     +E       +E ++ +A + 
Sbjct: 2810 LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQP 2869

Query: 169  QDIEIMMEGCEYAISNAEAFAEKLSRELQVLD----------------GANIQSIMASEK 212
                  ++  + A+S+ +   ++L +EL+ L                  A +Q      K
Sbjct: 2870 STSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTK 2929

Query: 213  QVNILM-KLLDEALK---EVDQIELKLSSYEEMLQSVKEQ--MDQISESNHLIHLSNTNN 266
               I+  +L  E L    E+ Q+ ++ SS+E   + +KEQ  M    +   L HL N   
Sbjct: 2930 AFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQN--- 2986

Query: 267  VKLLSEIEFLVNHMDLAKGHIKALQEGDL-ASSRGIEACTNAADALLQCMNVALRPGHDL 325
              L+ E+    +     K   +     +  AS  G +      + L   +N +L+  H  
Sbjct: 2987 --LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQK 3044

Query: 326  LLAVKQQQQRFSDLRE 341
             L ++Q    FS L E
Sbjct: 3045 ELRIQQLNSNFSQLLE 3060


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 38.5 bits (88), Expect = 0.028
 Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 26/271 (9%)

Query: 120  QRYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCE 179
            +R  R K++   + S L  E     E     GG   V     E+N + E + + M    E
Sbjct: 1125 ERTARAKVE--KLRSDLSRELEEISERLEEAGGATSV---QIEMNKKREAEFQKMRRDLE 1179

Query: 180  YAISNAEAFAEKLSREL--------QVLDGANIQSIMAS-EKQVNILMKLLDEALKEVDQ 230
             A    EA A  L ++         + +D  N+Q +    EK+ +     LD+    ++Q
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQID--NLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1237

Query: 231  IELKLSSYEEMLQSVKEQMDQ----ISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGH 286
            I    ++ E+M +++++QM++      E+   ++   +   KL +E   L   +D  +  
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297

Query: 287  IKALQEGDLASSRGIEACTNAADALLQCMNV---ALRPG-HDLLLAVKQQQQRFSDLREL 342
            I  L  G L  ++ +E      +  ++  N    AL+   HD  L  +Q ++      EL
Sbjct: 1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1357

Query: 343  FARRLASHLNNVFVQQGHDQSSTLAQHSVEL 373
              +R+ S  N+   Q      +   Q + EL
Sbjct: 1358 --QRVLSKANSEVAQWRTKYETDAIQRTEEL 1386



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 40/187 (21%), Positives = 80/187 (42%), Gaps = 33/187 (17%)

Query: 128  DFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEA 187
            D   ++ +L +E   S   + +    E+ + + Q    R ++  +I ++G +  +   EA
Sbjct: 1761 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH---RLDEAEQIALKGGKKQLQKLEA 1817

Query: 188  FAEKLSRELQVLDGANIQSIMA---SEKQVNILMKLLDEALKE-------VDQIELKLSS 237
               +L  EL+     N +S+     SE+++  L    +E  K        VD+++LK+ +
Sbjct: 1818 RVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1877

Query: 238  YEEMLQSVKEQMDQISESNHLIHLSNTNNV---KLLSEIEFLVNHMDLAKGHIKALQEGD 294
            Y+   +  +EQ             +NTN     K+  E++      D+A+  +  L+   
Sbjct: 1878 YKRQAEEAEEQ-------------ANTNLSKFRKVQHELDEAEERADIAESQVNKLR--- 1921

Query: 295  LASSRGI 301
             A SR I
Sbjct: 1922 -AKSRDI 1927



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 34/148 (22%), Positives = 58/148 (39%), Gaps = 16/148 (10%)

Query: 155  EVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQV 214
            E ++E ++  A+  Q+ E  +E      S+ E    +L  E        I+ +M   ++ 
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE--------IEDLMVDVERS 1435

Query: 215  NILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIE 274
            N     LD+  +  D+I        E  Q  +E   ++  S       +T   KL +  E
Sbjct: 1436 NAAAAALDKKQRNFDKI------LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1489

Query: 275  FLVNHMDLAKGHIKALQE--GDLASSRG 300
              + H++  K   K LQE   DL    G
Sbjct: 1490 ESLEHLETFKRENKNLQEEISDLTEQLG 1517


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 38.5 bits (88), Expect = 0.028
 Identities = 85/407 (20%), Positives = 159/407 (39%), Gaps = 56/407 (13%)

Query: 152  GDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAF-AEKLSRELQ--VLDGANIQSIM 208
            G  E+    Q+L A E+Q   + +E       NAE+  A  ++RELQ   L   N+Q  +
Sbjct: 740  GKSEMKKLRQQLEAAEKQIKHLEIE------KNAESSKASSITRELQGRELKLTNLQENL 793

Query: 209  AS--------EKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIH 260
            +         EK++ IL +   EA +E   ++  +      L   +EQ + +S       
Sbjct: 794  SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS------- 846

Query: 261  LSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALR 320
                      S++E L    +LA    K  +E D    + I+A     + + + M ++  
Sbjct: 847  ----------SDLEKL--RENLADMEAK-FREKDEREEQLIKAKEKLENDIAEIMKMSGD 893

Query: 321  PGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHP 380
                L     + + +  D+ EL  +   ++ N  F+Q+  +  +  A+ S +     H  
Sbjct: 894  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 953

Query: 381  FHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER---EIKDFFEVAKIKMTGTT 437
              ++L R        K +D  K    + N    L   YER   E K   E     +  T 
Sbjct: 954  EKKELER--------KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005

Query: 438  KESK-KFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSV--QSSGNRRSQSSSLLD 494
             +++ K      + S + QE E L   + K   + ++ + + +  Q +  +    +SL D
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065

Query: 495  MGNMSA---SDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFK 538
                +A   ++LD         + E  L++ + L   E   + +F K
Sbjct: 1066 TKQTNAKLQNELDTLKENNLKNVEE--LNKSKELLTVENQKMEEFRK 1110


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 38.5 bits (88), Expect = 0.028
 Identities = 85/407 (20%), Positives = 159/407 (39%), Gaps = 56/407 (13%)

Query: 152  GDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAF-AEKLSRELQ--VLDGANIQSIM 208
            G  E+    Q+L A E+Q   + +E       NAE+  A  ++RELQ   L   N+Q  +
Sbjct: 775  GKSEMKKLRQQLEAAEKQIKHLEIE------KNAESSKASSITRELQGRELKLTNLQENL 828

Query: 209  AS--------EKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIH 260
            +         EK++ IL +   EA +E   ++  +      L   +EQ + +S       
Sbjct: 829  SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS------- 881

Query: 261  LSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALR 320
                      S++E L    +LA    K  +E D    + I+A     + + + M ++  
Sbjct: 882  ----------SDLEKL--RENLADMEAK-FREKDEREEQLIKAKEKLENDIAEIMKMSGD 928

Query: 321  PGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHP 380
                L     + + +  D+ EL  +   ++ N  F+Q+  +  +  A+ S +     H  
Sbjct: 929  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 988

Query: 381  FHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYER---EIKDFFEVAKIKMTGTT 437
              ++L R        K +D  K    + N    L   YER   E K   E     +  T 
Sbjct: 989  EKKELER--------KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040

Query: 438  KESK-KFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSV--QSSGNRRSQSSSLLD 494
             +++ K      + S + QE E L   + K   + ++ + + +  Q +  +    +SL D
Sbjct: 1041 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1100

Query: 495  MGNMSA---SDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFK 538
                +A   ++LD         + E  L++ + L   E   + +F K
Sbjct: 1101 TKQTNAKLQNELDTLKENNLKNVEE--LNKSKELLTVENQKMEEFRK 1145


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 38.5 bits (88), Expect = 0.028
 Identities = 40/194 (20%), Positives = 86/194 (44%), Gaps = 27/194 (13%)

Query: 120  QRYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQ--DIEIMMEG 177
            + ++R+ +  +  S    E+S+   E  + T    ++V E ++   ++     IEI M G
Sbjct: 1369 KEHIRETLAKIQESQSKQEQSLNMKEKDNET---TKIVSEMEQFKPKDSALLRIEIEMLG 1425

Query: 178  CEYAISNAEAFAEKLSRE---LQVLDGA----------NIQSIMASEKQVNILMKLLDEA 224
                +  +    + +++E   LQ L             NI+ I+A   +    +K+    
Sbjct: 1426 LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC 1485

Query: 225  LKE----VDQIELKLSSYEEMLQSVKEQMDQISES-----NHLIHLSNTNNVKLLSEIEF 275
            LKE    ++++ + LS  E  + ++++Q++ I++        +       N+K +SE++ 
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQE 1545

Query: 276  LVNHMDLAKGHIKA 289
             VN +   K H KA
Sbjct: 1546 KVNELKQFKEHRKA 1559



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 140/758 (18%), Positives = 305/758 (40%), Gaps = 125/758 (16%)

Query: 153  DEEVVDEYQELNA--REEQDIEIMMEGCEYAISNAEAFAEKLSRELQV-LDGANIQSIMA 209
            D E++++ +++ +  +E+ +++ M+E     I+  E     L   +++ ++      ++ 
Sbjct: 1035 DNEIIEQQRKIFSLIQEKNELQQMLES---VIAEKEQLKTDLKENIEMTIENQEELRLLG 1091

Query: 210  SE--KQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISE-SNHLIHLSN--T 264
             E  KQ  I+ +  + A+K+  ++        E+ + +KE+  Q+ E    L+++    +
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151

Query: 265  NNVKLLSEIEFLVNHM---DLAKGHIKALQEGDLASS-----RGIEACTNAADALLQCMN 316
               K ++EIE L N +   +L   H++  +  +LA         +++ T     L +   
Sbjct: 1152 EMQKKINEIENLKNELKNKELTLEHMET-ERLELAQKLNENYEEVKSITKERKVLKELQK 1210

Query: 317  ------------------VALRPGHDLLLA---VKQQQQRFSDLRELFARRLASHLNNVF 355
                                L+   +L +A   +K+ Q+   +LR   + + A  +N   
Sbjct: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD 1270

Query: 356  VQQGHD--QSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDY 413
            +++ H   Q      H  +  LPN       +   ++  E +   +    +  TK+    
Sbjct: 1271 LEKSHTKLQEEIPVLHEEQELLPN-------VKEVSETQETMNELELLTEQSTTKDSTTL 1323

Query: 414  LSRLYER-EIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTS 472
                 ER  + + F+ ++ ++   TKE     T       +K+  E  H    +    T 
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKT-------IKEALEVKHDQLKEHIRETL 1376

Query: 473  SLNKLSVQSSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDF 532
            +     +Q S +++ QS ++ +  N         + TK     EQ   +   L   E + 
Sbjct: 1377 A----KIQESQSKQEQSLNMKEKDN---------ETTKIVSEMEQFKPKDSALLRIEIEM 1423

Query: 533  ISKFFKLQQ-HQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIF-RCI 590
            +    +LQ+ H  M     E +DL                + SE D +++ + +I  + +
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQ----------RLQEVLQSESDQLKENIKEIVAKHL 1473

Query: 591  EPELNNLIA---LGDKIDSFNSLYM-LVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRN 646
            E E    +A   L ++ ++ N L + L +    + T Q    A  ++  L N    ++  
Sbjct: 1474 ETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA--INDKLQN---KIQEI 1528

Query: 647  FDKCISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRG-DLDKAYTKL 705
            ++K     I+Q+ EV    + KV  L    +F+E     +S  ++ E +  +L     + 
Sbjct: 1529 YEKEEQFNIKQISEV----QEKVNEL---KQFKEHRKAKDSALQSIESKMLELTNRLQES 1581

Query: 706  IRGVFVNVEKVANESQKTPRDVVMMENFHHIFATLSRLKISCLE--AEKKEAKQKYTDHL 763
               + + +++   E  K  ++ + +E          +LK +  E  A+ KE+++K    L
Sbjct: 1582 QEEIQIMIKE--KEEMKRVQEALQIER--------DQLKENTKEIVAKMKESQEKEYQFL 1631

Query: 764  QSYVIYSLGQPLEKLNHFFEGVEARV--AQGIREEEV--SYQLAFNKQELRKVIKEYPG- 818
            +   +    + + ++ H  E  E +    + I  E +  +  L  N +E+R V KE    
Sbjct: 1632 KMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDL 1691

Query: 819  KEVKKGL--------DNLYKKVDKHLCEEENLLQVVWH 848
            + V++ L        +NL + + + L ++E L  V  H
Sbjct: 1692 RSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.131    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,818,826
Number of Sequences: 37866
Number of extensions: 1237608
Number of successful extensions: 5317
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 217
Number of HSP's that attempted gapping in prelim test: 4847
Number of HSP's gapped (non-prelim): 710
length of query: 894
length of database: 18,247,518
effective HSP length: 111
effective length of query: 783
effective length of database: 14,044,392
effective search space: 10996758936
effective search space used: 10996758936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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