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Search of human proteins with 67459914
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo
sapiens]
(457 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 941 0.0
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 825 0.0
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 825 0.0
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 687 0.0
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 641 0.0
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 641 0.0
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 615 e-176
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 560 e-160
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 249 5e-66
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 234 9e-62
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 234 9e-62
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 234 9e-62
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 223 2e-58
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 217 2e-56
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 206 5e-53
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 206 5e-53
gi|11415052 retinoid X receptor, beta [Homo sapiens] 203 3e-52
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 202 7e-52
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 197 1e-50
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 196 3e-50
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 187 2e-47
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 187 2e-47
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 185 8e-47
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 185 8e-47
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 185 8e-47
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 181 2e-45
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 181 2e-45
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 181 2e-45
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 181 2e-45
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 176 4e-44
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 941 bits (2432), Expect = 0.0
Identities = 457/457 (100%), Positives = 457/457 (100%)
Query: 1 MYESVEVGGPTPNPFLVVDFYNQNRACLLPEKGLPAPGPYSTPLRTPLWNGSNHSIETQS 60
MYESVEVGGPTPNPFLVVDFYNQNRACLLPEKGLPAPGPYSTPLRTPLWNGSNHSIETQS
Sbjct: 1 MYESVEVGGPTPNPFLVVDFYNQNRACLLPEKGLPAPGPYSTPLRTPLWNGSNHSIETQS 60
Query: 61 SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCH 120
SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCH
Sbjct: 61 SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCH 120
Query: 121 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVG 180
RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVG
Sbjct: 121 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVG 180
Query: 181 ELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQ 240
ELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQ
Sbjct: 181 ELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQ 240
Query: 241 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPL 300
LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPL
Sbjct: 241 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPL 300
Query: 301 TDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRK 360
TDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRK
Sbjct: 301 TDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRK 360
Query: 361 RRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSG 420
RRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSG
Sbjct: 361 RRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSG 420
Query: 421 QPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 457
QPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Sbjct: 421 QPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 457
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 825 bits (2132), Expect = 0.0
Identities = 410/424 (96%), Positives = 411/424 (96%), Gaps = 9/424 (2%)
Query: 34 LPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY 93
LP G YSTP S +IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY
Sbjct: 48 LPVSG-YSTP--------SPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY 98
Query: 94 HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV 153
HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV
Sbjct: 99 HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV 158
Query: 154 RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV 213
RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV
Sbjct: 159 RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV 218
Query: 214 SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT 273
SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT
Sbjct: 219 SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT 278
Query: 274 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD 333
PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD
Sbjct: 279 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD 338
Query: 334 RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL 393
RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL
Sbjct: 339 RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL 398
Query: 394 KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA 453
KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA
Sbjct: 399 KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA 458
Query: 454 THSP 457
THSP
Sbjct: 459 THSP 462
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 825 bits (2132), Expect = 0.0
Identities = 410/424 (96%), Positives = 411/424 (96%), Gaps = 9/424 (2%)
Query: 34 LPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY 93
LP G YSTP S +IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY
Sbjct: 48 LPVSG-YSTP--------SPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY 98
Query: 94 HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV 153
HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV
Sbjct: 99 HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV 158
Query: 154 RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV 213
RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV
Sbjct: 159 RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV 218
Query: 214 SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT 273
SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT
Sbjct: 219 SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT 278
Query: 274 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD 333
PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD
Sbjct: 279 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD 338
Query: 334 RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL 393
RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL
Sbjct: 339 RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL 398
Query: 394 KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA 453
KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA
Sbjct: 399 KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA 458
Query: 454 THSP 457
THSP
Sbjct: 459 THSP 462
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 687 bits (1772), Expect = 0.0
Identities = 346/460 (75%), Positives = 385/460 (83%), Gaps = 18/460 (3%)
Query: 1 MYESVEVGGPTPNPFLVVDFYNQN-RACLLPEKGLPAPGPYSTPLRTPLWNGSN--HSIE 57
M++ ++V +P L DFY + +C+L EK L A + L W + SIE
Sbjct: 1 MFDCMDVLSVSPGQIL--DFYTASPSSCMLQEKALKA---CFSGLTQTEWQHRHTAQSIE 55
Query: 58 TQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVY 117
TQS+SSEE+VPSPPSP P PR+YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM+Y
Sbjct: 56 TQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIY 115
Query: 118 TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTP 177
TCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE K EC+ESY +T
Sbjct: 116 TCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTA 175
Query: 178 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEF 237
E+ +L EK+RKAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK VEF
Sbjct: 176 ELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEF 235
Query: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
AK+LPGFT LTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF
Sbjct: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 295
Query: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
GPLTDLVF FANQLLPLEMDD ETGLLSAICLICGDRQDLE+P +VD LQEPLLEALK+Y
Sbjct: 296 GPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIY 355
Query: 358 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDT 417
+RKRRPS+PHMFPK+LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG +
Sbjct: 356 IRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEP 415
Query: 418 LSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 457
L+ G + SPS+SPSS +S + SP
Sbjct: 416 LTPSSSGNTAEH----------SPSISPSSVENSGVSQSP 445
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 641 bits (1654), Expect = 0.0
Identities = 313/395 (79%), Positives = 345/395 (87%), Gaps = 11/395 (2%)
Query: 52 SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 111
S S+ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CEGCKGFFRRSI
Sbjct: 48 SLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSI 107
Query: 112 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSE 171
QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKEV + +
Sbjct: 108 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPD 167
Query: 172 SYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCI 231
SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCI
Sbjct: 168 SYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCI 227
Query: 232 IKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQ 291
IK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQ
Sbjct: 228 IKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQ 287
Query: 292 MHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLL 351
MHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P++VD LQEPLL
Sbjct: 288 MHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLL 347
Query: 352 EALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLEN 411
EAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN
Sbjct: 348 EALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLEN 407
Query: 412 SEGLDTLSGQPG-----------GGGRDGGGLAPP 435
E + S QPG GG+ GGL P
Sbjct: 408 PEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 442
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 641 bits (1653), Expect = 0.0
Identities = 312/392 (79%), Positives = 344/392 (87%), Gaps = 11/392 (2%)
Query: 55 SIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 114
S+ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CEGCKGFFRRSIQKN
Sbjct: 62 SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN 121
Query: 115 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT 174
MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKEV + +SY
Sbjct: 122 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 181
Query: 175 LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 234
L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK
Sbjct: 182 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 241
Query: 235 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 294
VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 242 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 301
Query: 295 AGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEAL 354
AGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P++VD LQEPLLEAL
Sbjct: 302 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 361
Query: 355 KVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 414
++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN E
Sbjct: 362 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 421
Query: 415 LDTLSGQPG-----------GGGRDGGGLAPP 435
+ S QPG GG+ GGL P
Sbjct: 422 FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 453
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 615 bits (1585), Expect = e-176
Identities = 306/309 (99%), Positives = 307/309 (99%)
Query: 149 SKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 208
S +VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
Sbjct: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
Query: 209 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 268
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI
Sbjct: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
Query: 269 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 328
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC
Sbjct: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
Query: 329 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 388
LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE
Sbjct: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
Query: 389 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 448
RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN
Sbjct: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
Query: 449 RSSPATHSP 457
RSSPATHSP
Sbjct: 357 RSSPATHSP 365
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 560 bits (1444), Expect = e-160
Identities = 276/343 (80%), Positives = 302/343 (88%), Gaps = 10/343 (2%)
Query: 115 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT 174
M+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE K EC+ESY
Sbjct: 1 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 60
Query: 175 LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 234
+T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK
Sbjct: 61 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 120
Query: 235 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 294
VEFAK+LPGFT LTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 121 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 180
Query: 295 AGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEAL 354
AGFGPLTDLVF FANQLLPLEMDD ETGLLSAICLICGDRQDLE+P +VD LQEPLLEAL
Sbjct: 181 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 240
Query: 355 KVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 414
K+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
Sbjct: 241 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 300
Query: 415 LDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 457
+ L+ G + SPS+SPSS +S + SP
Sbjct: 301 HEPLTPSSSGNTAEH----------SPSISPSSVENSGVSQSP 333
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 249 bits (635), Expect = 5e-66
Identities = 136/357 (38%), Positives = 201/357 (56%), Gaps = 26/357 (7%)
Query: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 140
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 141 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 187
+KC VGM+ + V +D R +++KE + TPE +LI
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 188 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 237
+AH+ T Q K+ ++ + + +D++ + +F+++ T I + V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
G ++D +F L +DD E LL A+ L+ DR L D+++ QE L A + Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 358 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM-PPLIQEMLENSE 413
V R+ + PH +PK+LMK+TDLR I A A R + +K+E P + PPL E+ E+ E
Sbjct: 353 VNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQE 409
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 234 bits (598), Expect = 9e-62
Identities = 136/386 (35%), Positives = 205/386 (53%), Gaps = 32/386 (8%)
Query: 52 SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 111
S + +T+ + +PS L C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 82 SAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCKGFFRRTI 135
Query: 112 QKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 156
QKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
Query: 157 RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSSEQRV 213
R K+++E + T E ELI+ V +AH T Q K+ + + +
Sbjct: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
Query: 214 -------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILIL 266
+D++ + F+++ T I + V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
Query: 267 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA 326
R RY PE +T+T + + + R Q+ N G G ++D +F L +DD E LL A
Sbjct: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
Query: 327 ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKG 386
+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I A
Sbjct: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
Query: 387 AERVITLKMEIPGSM-PPLIQEMLEN 411
A R + +K+E P + PPL E+ E+
Sbjct: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 234 bits (598), Expect = 9e-62
Identities = 136/386 (35%), Positives = 205/386 (53%), Gaps = 32/386 (8%)
Query: 52 SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 111
S + +T+ + +PS L C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 82 SAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCKGFFRRTI 135
Query: 112 QKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 156
QKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
Query: 157 RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSSEQRV 213
R K+++E + T E ELI+ V +AH T Q K+ + + +
Sbjct: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
Query: 214 -------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILIL 266
+D++ + F+++ T I + V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
Query: 267 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA 326
R RY PE +T+T + + + R Q+ N G G ++D +F L +DD E LL A
Sbjct: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
Query: 327 ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKG 386
+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I A
Sbjct: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
Query: 387 AERVITLKMEIPGSM-PPLIQEMLEN 411
A R + +K+E P + PPL E+ E+
Sbjct: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 234 bits (598), Expect = 9e-62
Identities = 136/386 (35%), Positives = 205/386 (53%), Gaps = 32/386 (8%)
Query: 52 SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 111
S + +T+ + +PS L C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 82 SAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCKGFFRRTI 135
Query: 112 QKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 156
QKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
Query: 157 RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSSEQRV 213
R K+++E + T E ELI+ V +AH T Q K+ + + +
Sbjct: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
Query: 214 -------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILIL 266
+D++ + F+++ T I + V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
Query: 267 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA 326
R RY PE +T+T + + + R Q+ N G G ++D +F L +DD E LL A
Sbjct: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
Query: 327 ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKG 386
+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I A
Sbjct: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
Query: 387 AERVITLKMEIPGSM-PPLIQEMLEN 411
A R + +K+E P + PPL E+ E+
Sbjct: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 223 bits (569), Expect = 2e-58
Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 140
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 141 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 187
+KC VGM+ + V +D R +++KE + TPE +LI
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 188 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 237
+AH+ T Q K+ ++ + + +D++ + +F+++ T I + V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
G ++D +F L +DD E LL A+ L+ DR L D+++ QE L A + Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 358 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 387
V R+ + PH +PK+LMK +++ SI KGA
Sbjct: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 217 bits (553), Expect = 2e-56
Identities = 125/371 (33%), Positives = 199/371 (53%), Gaps = 23/371 (6%)
Query: 52 SNHSIETQSSSSEEIVPSP----------PSPPPLPRIYKPCFVCQDKSSGYHYGVSACE 101
S ++ SSSE+I P P PS P + C +C D+SSG HYGV +CE
Sbjct: 98 SQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCE 157
Query: 102 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 161
GCKGFF+R+I+K+++YTC +K+C+I+K RNRCQYCR QKC +GM +E+V+ +R + +
Sbjct: 158 GCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSR 217
Query: 162 KEV-PKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLW 220
+ + EC+ S +E++ +A P G NS+ V+
Sbjct: 218 ERAESEAECATS----GHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVT------ 267
Query: 221 DKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMT 280
+ K + VE+AK++P F+ LT+ DQ+ LL+A ++LI R QD +
Sbjct: 268 -NICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGIL 326
Query: 281 FSDGLTLNRTQMHNAGFGPLTDLVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQ 339
+ GL ++R+ H+AG G + D V +++ ++MD +E G L AI L D + L
Sbjct: 327 LATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSN 386
Query: 340 PDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPG 399
P V+ L+E + L+ Y +++ P +P F K+L+++ LRSI K E + K+
Sbjct: 387 PSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT 446
Query: 400 SMPPLIQEMLE 410
+ + EMLE
Sbjct: 447 PIDTFLMEMLE 457
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 206 bits (523), Expect = 5e-53
Identities = 124/376 (32%), Positives = 201/376 (53%), Gaps = 25/376 (6%)
Query: 61 SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT 118
S EI P P P++ + C VC DK+SG+HY V +CEGCKGFFRRS+ K Y
Sbjct: 29 SEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYI 88
Query: 119 CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT---- 174
CH +C ++ R +CQ CRL+KC + GM +E V ++ + K++ + E +++
Sbjct: 89 CHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLP 148
Query: 175 ------------LTPEVGELIEKVRKAHQE----TFPALCQLGKYTTNNSSEQRVSLDID 218
L+PE +IEK+ A Q+ +F ++ + R +
Sbjct: 149 PRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-Q 207
Query: 219 LWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDT 278
+ F+EL+ + + V+FAKQLPGF L+ DQI LLK + +++++L RY P ++
Sbjct: 208 RFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSES 267
Query: 279 MTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 337
+TF + NR AG + +F F+ + L+++DAE LL AI + DR ++
Sbjct: 268 ITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNV 327
Query: 338 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEI 397
+ +V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++
Sbjct: 328 QDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ- 386
Query: 398 PGSMPPLIQEMLENSE 413
+PPL+ E+ + E
Sbjct: 387 DKKLPPLLSEIWDVHE 402
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 206 bits (523), Expect = 5e-53
Identities = 124/376 (32%), Positives = 201/376 (53%), Gaps = 25/376 (6%)
Query: 61 SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT 118
S EI P P P++ + C VC DK+SG+HY V +CEGCKGFFRRS+ K Y
Sbjct: 74 SEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYI 133
Query: 119 CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT---- 174
CH +C ++ R +CQ CRL+KC + GM +E V ++ + K++ + E +++
Sbjct: 134 CHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLP 193
Query: 175 ------------LTPEVGELIEKVRKAHQE----TFPALCQLGKYTTNNSSEQRVSLDID 218
L+PE +IEK+ A Q+ +F ++ + R +
Sbjct: 194 PRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-Q 252
Query: 219 LWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDT 278
+ F+EL+ + + V+FAKQLPGF L+ DQI LLK + +++++L RY P ++
Sbjct: 253 RFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSES 312
Query: 279 MTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 337
+TF + NR AG + +F F+ + L+++DAE LL AI + DR ++
Sbjct: 313 ITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNV 372
Query: 338 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEI 397
+ +V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++
Sbjct: 373 QDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ- 431
Query: 398 PGSMPPLIQEMLENSE 413
+PPL+ E+ + E
Sbjct: 432 DKKLPPLLSEIWDVHE 447
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 203 bits (516), Expect = 3e-52
Identities = 132/414 (31%), Positives = 209/414 (50%), Gaps = 27/414 (6%)
Query: 10 PTPNPFLVVDFYNQNRACLLPEKGLPAPGP--YSTPLRTPLWNGSNHSIETQSSSSEEIV 67
P +PF V+ + + GLP P P +S P+ +P N S S+ S E V
Sbjct: 128 PLGSPFPVI-------SSSMGSPGLPPPAPPGFSGPVSSPQIN-STVSLPGGGSGPPEDV 179
Query: 68 PSP---------PSPPPLPRIYKP-CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVY 117
P P PP P K C +C D+SSG HYGV +CEGCKGFF+R+I+K++ Y
Sbjct: 180 KPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTY 239
Query: 118 TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTP 177
+C +K+C ++K RNRCQYCR QKC GM +E+V+ +R + K + E +
Sbjct: 240 SCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEM 299
Query: 178 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEF 237
V ++E Q++ + G + SS D + + K + VE+
Sbjct: 300 PVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPN------DPVTNICQAADKQLFTLVEW 353
Query: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
AK++P F++L + DQ+ LL+A ++LI R +D + + GL ++R H+AG
Sbjct: 354 AKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGV 413
Query: 298 GPLTDLVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 356
G + D V +++ + MD E G L AI L D + L P V++L+E + +L+
Sbjct: 414 GAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLET 473
Query: 357 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 410
Y +++ P + F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 474 YCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 202 bits (513), Expect = 7e-52
Identities = 141/450 (31%), Positives = 221/450 (49%), Gaps = 66/450 (14%)
Query: 29 LPEKGLPAPG-PYSTPL-----RTPLWNGSNHSIE-----TQSSSSEEIVPSPPSPP--- 74
LP G P PG P S+P P G + + + + S++ ++P P P
Sbjct: 13 LPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERK 72
Query: 75 ----PLPRI--YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMV--YTCHRDKNCI 126
P P++ ++ C VC DK+SG+HY V +CEGCKGFFRRS+ + Y C C
Sbjct: 73 RKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQ 132
Query: 127 INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPK---------------PECSE 171
++ R +CQ CRL+KC E GM ++ V ++ +KK++ K P+ S
Sbjct: 133 MDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSS 192
Query: 172 SYTLTP-------EVG----------ELIEKVRKAHQETFPALCQLGKYTTNNSSE---- 210
S P E G +L Q+ A Q K + ++ +
Sbjct: 193 SSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPW 252
Query: 211 ------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264
Q + F+EL+ + + V+FAKQ+PGF L DQI LLKA+ ++I+
Sbjct: 253 PLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIM 312
Query: 265 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGL 323
+L RY E + +TF T ++ H AG + +F F+ + L +DDAE L
Sbjct: 313 LLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYAL 372
Query: 324 LSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSIS 383
L AI + DR ++++P RV+ LQ+P +EAL Y R +RP FP+MLMK+ LR++S
Sbjct: 373 LIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLS 432
Query: 384 AKGAERVITLKMEIPGSMPPLIQEMLENSE 413
+ +E+V L+++ +PPL+ E+ + E
Sbjct: 433 SVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 197 bits (502), Expect = 1e-50
Identities = 128/391 (32%), Positives = 201/391 (51%), Gaps = 25/391 (6%)
Query: 38 GPYSTPL-RTPLWNGSNHSIETQS-----SSSEEI-----------VPSPPSPPPLPRIY 80
GP+S + TP S S + S SSSE+I VP+ PS
Sbjct: 73 GPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTK 132
Query: 81 KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRL 140
C +C D+SSG HYGV +CEGCKGFF+R+++K++ YTC +K+C+I+K RNRCQYCR
Sbjct: 133 HICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRY 192
Query: 141 QKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQL 200
QKC +GM +E+V+ +R + K + E T + +E++ +A P +
Sbjct: 193 QKCLAMGMKREAVQEERQRGK---DRNENEVESTSSANEDMPVERILEAELAVEP---KT 246
Query: 201 GKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAAC 260
Y N S + D + + K + VE+AK++P F+ L + DQ+ LL+A
Sbjct: 247 ETYVEANMGLNPSSPN-DPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGW 305
Query: 261 LDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-FANQLLPLEMDDA 319
++LI R +D + + GL ++R H+AG G + D V +++ ++MD
Sbjct: 306 NELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKT 365
Query: 320 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 379
E G L AI L D + L P V+ L+E + +L+ Y + + P +P F K+L+++ L
Sbjct: 366 ELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPAL 425
Query: 380 RSISAKGAERVITLKMEIPGSMPPLIQEMLE 410
RSI K E + K+ + + EMLE
Sbjct: 426 RSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 196 bits (499), Expect = 3e-50
Identities = 129/382 (33%), Positives = 201/382 (52%), Gaps = 14/382 (3%)
Query: 43 PLRTPLWNG-SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACE 101
P+R P G I S + VPSPPS P C VC D ++ HYGV CE
Sbjct: 223 PIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGS-PSNEGLCAVCGDNAACQHYGVRTCE 281
Query: 102 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND--RNK 159
GCKGFF+R++QKN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D + +
Sbjct: 282 GCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGR 341
Query: 160 KKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLG-KYTTNNSSEQRVSLDID 218
+ + KP+ + + LI + +AH ++ PA+ L N Q D
Sbjct: 342 RGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQ 401
Query: 219 LWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDT 278
+F +L T + +A+++PGF L ADQ L ++A L++ +LR+ R P +
Sbjct: 402 HIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGK 461
Query: 279 MTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE 338
+ F +G+ L+R Q GFG D + F++ L + +D + ++A+ ++ +R L+
Sbjct: 462 LIFCNGVVLHRLQCVR-GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLK 519
Query: 339 QPDRVDMLQEPLLEALKVYVRKRRP--SRPHMFPKMLMKITDLRSISAKGAERVITLKME 396
+P RV+ LQ ++ LK +V +RP+ K+L K+ +LR++ +G +R+ LK+E
Sbjct: 520 EPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLE 579
Query: 397 IPGSMPPLIQEMLENSEGLDTL 418
P +I ++ LDTL
Sbjct: 580 DLVPPPAIIDKLF-----LDTL 596
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 187 bits (474), Expect = 2e-47
Identities = 121/344 (35%), Positives = 185/344 (53%), Gaps = 22/344 (6%)
Query: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142
C VC D +S HYGV CEGCKGFF+R++QKN Y C +K+C ++K RNRCQ+CR QK
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 143 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 202
C VGM KE VR D K ++ + + +P L+ + +AH ++ P+ +L
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASP--ANLLTSLVRAHLDSGPSTAKL-- 382
Query: 203 YTTNNSSEQRVSL------DIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLL 256
+ S Q + L D +F +L + + ++A+++PGF L+ ADQ LL
Sbjct: 383 ---DYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLL 439
Query: 257 KAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEM 316
++A L++ ILR+ R P + + F GL L+R Q GFG D + AF+ L L +
Sbjct: 440 ESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLV 498
Query: 317 DDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR--KRRPSRPHMFPKMLM 374
D LSA+ LI DR L++P RV+ LQ + LK +V P ++L
Sbjct: 499 DVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG 557
Query: 375 KITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTL 418
K+ +LR++ +G +R+ LK+E PP+I ++ +DTL
Sbjct: 558 KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIF-----MDTL 596
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 187 bits (474), Expect = 2e-47
Identities = 121/344 (35%), Positives = 185/344 (53%), Gaps = 22/344 (6%)
Query: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142
C VC D +S HYGV CEGCKGFF+R++QKN Y C +K+C ++K RNRCQ+CR QK
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 143 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 202
C VGM KE VR D K ++ + + +P L+ + +AH ++ P+ +L
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASP--ANLLTSLVRAHLDSGPSTAKL-- 382
Query: 203 YTTNNSSEQRVSL------DIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLL 256
+ S Q + L D +F +L + + ++A+++PGF L+ ADQ LL
Sbjct: 383 ---DYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLL 439
Query: 257 KAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEM 316
++A L++ ILR+ R P + + F GL L+R Q GFG D + AF+ L L +
Sbjct: 440 ESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLV 498
Query: 317 DDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR--KRRPSRPHMFPKMLM 374
D LSA+ LI DR L++P RV+ LQ + LK +V P ++L
Sbjct: 499 DVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG 557
Query: 375 KITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTL 418
K+ +LR++ +G +R+ LK+E PP+I ++ +DTL
Sbjct: 558 KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIF-----MDTL 596
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 185 bits (469), Expect = 8e-47
Identities = 127/361 (35%), Positives = 184/361 (50%), Gaps = 21/361 (5%)
Query: 68 PSPPSPPPLPRIYKP--CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNC 125
PS PSPP C VC D ++ HYGV CEGCKGFF+R++QKN Y C +KNC
Sbjct: 286 PSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNC 345
Query: 126 IINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKEVPKPECSESYTLTP 177
++K RNRCQYCR QKC VGM KE VR D K K K + E S+ +P
Sbjct: 346 PVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSP 405
Query: 178 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEF 237
+ + VR A ++ P +Y + + D + +F L T I + +
Sbjct: 406 PICMMNALVR-ALTDSTPRDLDYSRYCP--TDQAAAGTDAEHVQQFYNLLTASIDVSRSW 462
Query: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
A+++PGFT L DQ L+++A L++ +LR+ R +D F +GL L+R Q GF
Sbjct: 463 AEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-GF 521
Query: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
G D + F+ L L +D LSA+ +I +R L++P RV+ L + +LK +
Sbjct: 522 GEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRVEELCNKITSSLKDH 580
Query: 358 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDT 417
K + P K+L + +LR I G +R+ LK+E S P +I ++ LDT
Sbjct: 581 QSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLF-----LDT 634
Query: 418 L 418
L
Sbjct: 635 L 635
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 185 bits (469), Expect = 8e-47
Identities = 127/361 (35%), Positives = 184/361 (50%), Gaps = 21/361 (5%)
Query: 68 PSPPSPPPLPRIYKP--CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNC 125
PS PSPP C VC D ++ HYGV CEGCKGFF+R++QKN Y C +KNC
Sbjct: 275 PSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNC 334
Query: 126 IINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKEVPKPECSESYTLTP 177
++K RNRCQYCR QKC VGM KE VR D K K K + E S+ +P
Sbjct: 335 PVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSP 394
Query: 178 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEF 237
+ + VR A ++ P +Y + + D + +F L T I + +
Sbjct: 395 PICMMNALVR-ALTDSTPRDLDYSRYCP--TDQAAAGTDAEHVQQFYNLLTASIDVSRSW 451
Query: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
A+++PGFT L DQ L+++A L++ +LR+ R +D F +GL L+R Q GF
Sbjct: 452 AEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-GF 510
Query: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
G D + F+ L L +D LSA+ +I +R L++P RV+ L + +LK +
Sbjct: 511 GEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRVEELCNKITSSLKDH 569
Query: 358 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDT 417
K + P K+L + +LR I G +R+ LK+E S P +I ++ LDT
Sbjct: 570 QSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLF-----LDT 623
Query: 418 L 418
L
Sbjct: 624 L 624
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 185 bits (469), Expect = 8e-47
Identities = 127/361 (35%), Positives = 184/361 (50%), Gaps = 21/361 (5%)
Query: 68 PSPPSPPPLPRIYKP--CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNC 125
PS PSPP C VC D ++ HYGV CEGCKGFF+R++QKN Y C +KNC
Sbjct: 275 PSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNC 334
Query: 126 IINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKEVPKPECSESYTLTP 177
++K RNRCQYCR QKC VGM KE VR D K K K + E S+ +P
Sbjct: 335 PVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSP 394
Query: 178 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEF 237
+ + VR A ++ P +Y + + D + +F L T I + +
Sbjct: 395 PICMMNALVR-ALTDSTPRDLDYSRYCP--TDQAAAGTDAEHVQQFYNLLTASIDVSRSW 451
Query: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
A+++PGFT L DQ L+++A L++ +LR+ R +D F +GL L+R Q GF
Sbjct: 452 AEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-GF 510
Query: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
G D + F+ L L +D LSA+ +I +R L++P RV+ L + +LK +
Sbjct: 511 GEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRVEELCNKITSSLKDH 569
Query: 358 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDT 417
K + P K+L + +LR I G +R+ LK+E S P +I ++ LDT
Sbjct: 570 QSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLF-----LDT 623
Query: 418 L 418
L
Sbjct: 624 L 624
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 181 bits (458), Expect = 2e-45
Identities = 121/386 (31%), Positives = 187/386 (48%), Gaps = 12/386 (3%)
Query: 31 EKGLPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKP---CFVCQ 87
+ GL +P Y + P+ GS + S IV P + P C VC
Sbjct: 53 QNGLDSPPLYPS---APILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCG 109
Query: 88 DKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 147
D +SGYHYGV++CE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 148 MSKESVRNDRNK--KKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTT 205
M KE VR DR + ++K + + S L P +L++ +K + + L
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP---QLVQPAKKPYNKIVSHLLVAEPEKI 226
Query: 206 NNSSEQRV-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264
+ V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++IL
Sbjct: 227 YAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEIL 286
Query: 265 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLL 324
IL + R +D + ++D ++ Q AG L + + + ++++ E L
Sbjct: 287 ILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTL 346
Query: 325 SAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISA 384
AI L D +E + V LQ+ L EAL+ Y + P KMLM + LR S
Sbjct: 347 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 406
Query: 385 KGAERVITLKMEIPGSMPPLIQEMLE 410
K + +K+E M L EMLE
Sbjct: 407 KAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 181 bits (458), Expect = 2e-45
Identities = 121/386 (31%), Positives = 187/386 (48%), Gaps = 12/386 (3%)
Query: 31 EKGLPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKP---CFVCQ 87
+ GL +P Y + P+ GS + S IV P + P C VC
Sbjct: 53 QNGLDSPPLYPS---APILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCG 109
Query: 88 DKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 147
D +SGYHYGV++CE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 148 MSKESVRNDRNK--KKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTT 205
M KE VR DR + ++K + + S L P +L++ +K + + L
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP---QLVQPAKKPYNKIVSHLLVAEPEKI 226
Query: 206 NNSSEQRV-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264
+ V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++IL
Sbjct: 227 YAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEIL 286
Query: 265 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLL 324
IL + R +D + ++D ++ Q AG L + + + ++++ E L
Sbjct: 287 ILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTL 346
Query: 325 SAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISA 384
AI L D +E + V LQ+ L EAL+ Y + P KMLM + LR S
Sbjct: 347 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 406
Query: 385 KGAERVITLKMEIPGSMPPLIQEMLE 410
K + +K+E M L EMLE
Sbjct: 407 KAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 181 bits (458), Expect = 2e-45
Identities = 121/386 (31%), Positives = 187/386 (48%), Gaps = 12/386 (3%)
Query: 31 EKGLPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKP---CFVCQ 87
+ GL +P Y + P+ GS + S IV P + P C VC
Sbjct: 76 QNGLDSPPLYPS---APILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCG 132
Query: 88 DKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 147
D +SGYHYGV++CE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 133 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 192
Query: 148 MSKESVRNDRNK--KKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTT 205
M KE VR DR + ++K + + S L P +L++ +K + + L
Sbjct: 193 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP---QLVQPAKKPYNKIVSHLLVAEPEKI 249
Query: 206 NNSSEQRV-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264
+ V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++IL
Sbjct: 250 YAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEIL 309
Query: 265 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLL 324
IL + R +D + ++D ++ Q AG L + + + ++++ E L
Sbjct: 310 ILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTL 369
Query: 325 SAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISA 384
AI L D +E + V LQ+ L EAL+ Y + P KMLM + LR S
Sbjct: 370 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 429
Query: 385 KGAERVITLKMEIPGSMPPLIQEMLE 410
K + +K+E M L EMLE
Sbjct: 430 KAVQHFYNIKLEGKVPMHKLFLEMLE 455
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 181 bits (458), Expect = 2e-45
Identities = 121/386 (31%), Positives = 187/386 (48%), Gaps = 12/386 (3%)
Query: 31 EKGLPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKP---CFVCQ 87
+ GL +P Y + P+ GS + S IV P + P C VC
Sbjct: 53 QNGLDSPPLYPS---APILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCG 109
Query: 88 DKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 147
D +SGYHYGV++CE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 148 MSKESVRNDRNK--KKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTT 205
M KE VR DR + ++K + + S L P +L++ +K + + L
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP---QLVQPAKKPYNKIVSHLLVAEPEKI 226
Query: 206 NNSSEQRV-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264
+ V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++IL
Sbjct: 227 YAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEIL 286
Query: 265 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLL 324
IL + R +D + ++D ++ Q AG L + + + ++++ E L
Sbjct: 287 ILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTL 346
Query: 325 SAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISA 384
AI L D +E + V LQ+ L EAL+ Y + P KMLM + LR S
Sbjct: 347 KAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTST 406
Query: 385 KGAERVITLKMEIPGSMPPLIQEMLE 410
K + +K+E M L EMLE
Sbjct: 407 KAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 176 bits (446), Expect = 4e-44
Identities = 123/358 (34%), Positives = 181/358 (50%), Gaps = 30/358 (8%)
Query: 71 PSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKV 130
P P + C VC DKSSG HYGV CEGCK FF+RSI++N+ YTC +++C I++
Sbjct: 44 PGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQH 103
Query: 131 TRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT--------------LT 176
RN+CQYCRL+KCF VGM KE+V+ R + +P + S + L
Sbjct: 104 HRNQCQYCRLKKCFRVGMRKEAVQ--RGRIPHSLPGAVAASSGSPPGSALAAVASGGDLF 161
Query: 177 P--EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 234
P V ELI ++ +A E +PA G++ + V L ID EL+ + + T
Sbjct: 162 PGQPVSELIAQLLRA--EPYPAAA--GRFGAGGGAAGAV-LGID---NVCELAARLLFST 213
Query: 235 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 294
VE+A+ P F L +ADQ+ LL+ + ++ +L P T L+ M
Sbjct: 214 VEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLH-TAPLLAAAGLHAAPMAA 272
Query: 295 AGFGPLTDLVFAFANQ---LLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLL 351
D V AF Q L L++D AE G L AI L D L P V+ LQE
Sbjct: 273 ERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQ 332
Query: 352 EALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML 409
AL YVR + PS+P F ++L+++ LR++ A ++ +++ + LI++ML
Sbjct: 333 VALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDML 390
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,216,914
Number of Sequences: 37866
Number of extensions: 1170493
Number of successful extensions: 9701
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 144
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 8944
Number of HSP's gapped (non-prelim): 641
length of query: 457
length of database: 18,247,518
effective HSP length: 106
effective length of query: 351
effective length of database: 14,233,722
effective search space: 4996036422
effective search space used: 4996036422
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.