Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 66932902
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66932902 SREBF chaperone protein [Homo sapiens]
(1279 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66932902 SREBF chaperone protein [Homo sapiens] 2605 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 95 5e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 95 5e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 95 5e-19
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 81 6e-15
gi|157266266 WD repeat domain 86 [Homo sapiens] 77 1e-13
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 74 7e-13
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 74 7e-13
gi|52145305 patched 2 [Homo sapiens] 73 2e-12
gi|23199987 WD repeat domain 5B [Homo sapiens] 71 8e-12
gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso... 70 1e-11
gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo... 70 1e-11
gi|134254450 patched isoform S [Homo sapiens] 70 1e-11
gi|134254435 patched isoform S [Homo sapiens] 70 1e-11
gi|134254468 patched isoform S [Homo sapiens] 70 1e-11
gi|134254452 patched isoform S [Homo sapiens] 70 1e-11
gi|134254432 patched isoform L' [Homo sapiens] 70 1e-11
gi|134254466 patched isoform M [Homo sapiens] 70 1e-11
gi|134254446 patched isoform L [Homo sapiens] 70 1e-11
gi|16554629 WD repeat domain 5 [Homo sapiens] 69 2e-11
gi|16554627 WD repeat domain 5 [Homo sapiens] 69 2e-11
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 65 3e-10
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 65 3e-10
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 65 4e-10
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 65 4e-10
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 65 4e-10
gi|32189425 WD repeat domain 69 [Homo sapiens] 64 7e-10
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 63 2e-09
gi|113865883 WD repeat domain 38 [Homo sapiens] 57 1e-07
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 55 4e-07
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 2605 bits (6751), Expect = 0.0
Identities = 1279/1279 (100%), Positives = 1279/1279 (100%)
Query: 1 MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTP 60
MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTP
Sbjct: 1 MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTP 60
Query: 61 VKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLS 120
VKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLS
Sbjct: 61 VKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLS 120
Query: 121 RAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQN 180
RAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQN
Sbjct: 121 RAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQN 180
Query: 181 DWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVF 240
DWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVF
Sbjct: 181 DWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVF 240
Query: 241 QHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIY 300
QHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIY
Sbjct: 241 QHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIY 300
Query: 301 FSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLEN 360
FSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLEN
Sbjct: 301 FSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLEN 360
Query: 361 VLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLF 420
VLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLF
Sbjct: 361 VLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLF 420
Query: 421 AVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAV 480
AVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAV
Sbjct: 421 AVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAV 480
Query: 481 RPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLR 540
RPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLR
Sbjct: 481 RPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLR 540
Query: 541 NYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPER 600
NYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPER
Sbjct: 541 NYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPER 600
Query: 601 GGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLR 660
GGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLR
Sbjct: 601 GGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLR 660
Query: 661 LNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGI 720
LNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGI
Sbjct: 661 LNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGI 720
Query: 721 VLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIE 780
VLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIE
Sbjct: 721 VLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIE 780
Query: 781 CLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDG 840
CLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDG
Sbjct: 781 CLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDG 840
Query: 841 GKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAV 900
GKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAV
Sbjct: 841 GKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAV 900
Query: 901 CGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSL 960
CGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSL
Sbjct: 901 CGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSL 960
Query: 961 AWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRI 1020
AWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRI
Sbjct: 961 AWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRI 1020
Query: 1021 VAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQK 1080
VAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQK
Sbjct: 1021 VAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQK 1080
Query: 1081 PITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDG 1140
PITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDG
Sbjct: 1081 PITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDG 1140
Query: 1141 AICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDL 1200
AICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDL
Sbjct: 1141 AICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDL 1200
Query: 1201 GCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVC 1260
GCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVC
Sbjct: 1201 GCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVC 1260
Query: 1261 NFGSELSLVYVPSVLEKLD 1279
NFGSELSLVYVPSVLEKLD
Sbjct: 1261 NFGSELSLVYVPSVLEKLD 1279
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 94.7 bits (234), Expect = 5e-19
Identities = 81/271 (29%), Positives = 118/271 (43%), Gaps = 41/271 (15%)
Query: 970 IWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSL 1029
I L+ GN IV G L+VW A+ G + + G+ + D I++ + +L
Sbjct: 266 ITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL 325
Query: 1030 DFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVAC-HLTHTVPCAHQKPITALKAA 1088
++ ET + L Y + TV C HL H+K
Sbjct: 326 KVWNAETGECIHTL----------------YGHTSTVRCMHL-------HEK-------- 354
Query: 1089 AGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVL 1148
R+V+GS+D TLRV+ +E CL L GH A+ V D V+ SG D + +WD
Sbjct: 355 --RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPE 411
Query: 1149 TGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSI--QQDLGCGASL 1206
T + + + H V SL V+S LD I +WD TG +++ Q L G L
Sbjct: 412 TETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 471
Query: 1207 GVISDNLLVTGG-QGCVSFWDLNYGDLLQTV 1236
DN+LV+G V WD+ G LQT+
Sbjct: 472 ---KDNILVSGNADSTVKIWDIKTGQCLQTL 499
Score = 93.6 bits (231), Expect = 1e-18
Identities = 66/300 (22%), Positives = 130/300 (43%), Gaps = 36/300 (12%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
G +WS +++ N+I+ G + L+VW+A G + +S + + +KR+V+ +
Sbjct: 304 GGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDA 363
Query: 1028 SLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKA 1087
+L + +ET L L H + ++
Sbjct: 364 TLRVWDIETGQCLHVLM--------------------------------GHVAAVRCVQY 391
Query: 1088 AAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDV 1147
R+V+G+ D ++V+ E CL TLQGH+ + ++ D V+ SG D +I +WDV
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVV-SGSLDTSIRVWDV 450
Query: 1148 LTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLG 1207
TG+ + + H+ + + + ++S D + IWD TG ++Q +++
Sbjct: 451 ETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT 510
Query: 1208 VISDN---LLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGS 1264
+ N ++ + G V WDL G+ ++ + ++ + + N +VC GS
Sbjct: 511 CLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 570
Score = 40.0 bits (92), Expect = 0.014
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 763 PETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDS 822
PETE L+GH + L DG+ +VS L + VWD +TG+C+ + G Q S
Sbjct: 410 PETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL--TGHQSLTS 467
Query: 823 GV 824
G+
Sbjct: 468 GM 469
Score = 33.1 bits (74), Expect = 1.7
Identities = 16/39 (41%), Positives = 21/39 (53%)
Query: 771 VLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCL 809
VL GH+ + C+ DG +VS V VWD +T CL
Sbjct: 378 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCL 416
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 94.7 bits (234), Expect = 5e-19
Identities = 81/271 (29%), Positives = 118/271 (43%), Gaps = 41/271 (15%)
Query: 970 IWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSL 1029
I L+ GN IV G L+VW A+ G + + G+ + D I++ + +L
Sbjct: 384 ITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL 443
Query: 1030 DFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVAC-HLTHTVPCAHQKPITALKAA 1088
++ ET + L Y + TV C HL H+K
Sbjct: 444 KVWNAETGECIHTL----------------YGHTSTVRCMHL-------HEK-------- 472
Query: 1089 AGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVL 1148
R+V+GS+D TLRV+ +E CL L GH A+ V D V+ SG D + +WD
Sbjct: 473 --RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPE 529
Query: 1149 TGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSI--QQDLGCGASL 1206
T + + + H V SL V+S LD I +WD TG +++ Q L G L
Sbjct: 530 TETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 589
Query: 1207 GVISDNLLVTGG-QGCVSFWDLNYGDLLQTV 1236
DN+LV+G V WD+ G LQT+
Sbjct: 590 ---KDNILVSGNADSTVKIWDIKTGQCLQTL 617
Score = 93.6 bits (231), Expect = 1e-18
Identities = 66/300 (22%), Positives = 130/300 (43%), Gaps = 36/300 (12%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
G +WS +++ N+I+ G + L+VW+A G + +S + + +KR+V+ +
Sbjct: 422 GGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDA 481
Query: 1028 SLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKA 1087
+L + +ET L L H + ++
Sbjct: 482 TLRVWDIETGQCLHVLM--------------------------------GHVAAVRCVQY 509
Query: 1088 AAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDV 1147
R+V+G+ D ++V+ E CL TLQGH+ + ++ D V+ SG D +I +WDV
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVV-SGSLDTSIRVWDV 568
Query: 1148 LTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLG 1207
TG+ + + H+ + + + ++S D + IWD TG ++Q +++
Sbjct: 569 ETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT 628
Query: 1208 VISDN---LLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGS 1264
+ N ++ + G V WDL G+ ++ + ++ + + N +VC GS
Sbjct: 629 CLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 688
Score = 40.0 bits (92), Expect = 0.014
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 763 PETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDS 822
PETE L+GH + L DG+ +VS L + VWD +TG+C+ + G Q S
Sbjct: 528 PETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL--TGHQSLTS 585
Query: 823 GV 824
G+
Sbjct: 586 GM 587
Score = 33.1 bits (74), Expect = 1.7
Identities = 16/39 (41%), Positives = 21/39 (53%)
Query: 771 VLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCL 809
VL GH+ + C+ DG +VS V VWD +T CL
Sbjct: 496 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCL 534
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 94.7 bits (234), Expect = 5e-19
Identities = 81/271 (29%), Positives = 118/271 (43%), Gaps = 41/271 (15%)
Query: 970 IWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSL 1029
I L+ GN IV G L+VW A+ G + + G+ + D I++ + +L
Sbjct: 304 ITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL 363
Query: 1030 DFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVAC-HLTHTVPCAHQKPITALKAA 1088
++ ET + L Y + TV C HL H+K
Sbjct: 364 KVWNAETGECIHTL----------------YGHTSTVRCMHL-------HEK-------- 392
Query: 1089 AGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVL 1148
R+V+GS+D TLRV+ +E CL L GH A+ V D V+ SG D + +WD
Sbjct: 393 --RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPE 449
Query: 1149 TGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSI--QQDLGCGASL 1206
T + + + H V SL V+S LD I +WD TG +++ Q L G L
Sbjct: 450 TETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL 509
Query: 1207 GVISDNLLVTGG-QGCVSFWDLNYGDLLQTV 1236
DN+LV+G V WD+ G LQT+
Sbjct: 510 ---KDNILVSGNADSTVKIWDIKTGQCLQTL 537
Score = 93.6 bits (231), Expect = 1e-18
Identities = 66/300 (22%), Positives = 130/300 (43%), Gaps = 36/300 (12%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
G +WS +++ N+I+ G + L+VW+A G + +S + + +KR+V+ +
Sbjct: 342 GGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDA 401
Query: 1028 SLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKA 1087
+L + +ET L L H + ++
Sbjct: 402 TLRVWDIETGQCLHVLM--------------------------------GHVAAVRCVQY 429
Query: 1088 AAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDV 1147
R+V+G+ D ++V+ E CL TLQGH+ + ++ D V+ SG D +I +WDV
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVV-SGSLDTSIRVWDV 488
Query: 1148 LTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLG 1207
TG+ + + H+ + + + ++S D + IWD TG ++Q +++
Sbjct: 489 ETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT 548
Query: 1208 VISDN---LLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGS 1264
+ N ++ + G V WDL G+ ++ + ++ + + N +VC GS
Sbjct: 549 CLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 608
Score = 40.0 bits (92), Expect = 0.014
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 763 PETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDS 822
PETE L+GH + L DG+ +VS L + VWD +TG+C+ + G Q S
Sbjct: 448 PETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL--TGHQSLTS 505
Query: 823 GV 824
G+
Sbjct: 506 GM 507
Score = 33.1 bits (74), Expect = 1.7
Identities = 16/39 (41%), Positives = 21/39 (53%)
Query: 771 VLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCL 809
VL GH+ + C+ DG +VS V VWD +T CL
Sbjct: 416 VLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCL 454
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 81.3 bits (199), Expect = 6e-15
Identities = 54/197 (27%), Positives = 102/197 (51%), Gaps = 8/197 (4%)
Query: 259 HPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKID-----MVKSKW 313
+P+ S AE + E +++ +V +Y I+F YI + I +V SK
Sbjct: 596 NPNLTISFTAERSIEDELNRESD-SDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKV 654
Query: 314 GLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTP- 372
L +A ++ VLSS+ S+G+ + GL TL E+ P+LV+ +G++N+ +L ++
Sbjct: 655 SLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDER 714
Query: 373 -VDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFL 431
+ ++ + L + S+ + +E +G +++PA+ F LFA + + DF L
Sbjct: 715 LQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLL 774
Query: 432 QMLFFTTVLSIDIRRME 448
Q+ F ++L +DI+R E
Sbjct: 775 QITCFVSLLGLDIKRQE 791
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 77.0 bits (188), Expect = 1e-13
Identities = 49/161 (30%), Positives = 72/161 (44%), Gaps = 7/161 (4%)
Query: 1073 TVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMV 1132
+ PCA + AA G LVTGS D T +V+++ CC TL+GH+GA+ + +D
Sbjct: 153 STPCAEEA------AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
Query: 1133 LA-SGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGI 1191
A +G D I WD+L+G ++ HRG V L V S D + W TG
Sbjct: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
Query: 1192 KFYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDL 1232
+ ++L + L G C +D G+L
Sbjct: 267 CVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGEL 307
Score = 57.4 bits (137), Expect = 9e-08
Identities = 59/184 (32%), Positives = 78/184 (42%), Gaps = 17/184 (9%)
Query: 977 GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLET 1036
G L+V G + G +VW G C + +G + LD A GS D ++
Sbjct: 163 GGLLVTGSTDGTAKVWQVASGC-CHQTLRGHTGAVLCLVLDTPGHTA-FTGSTDA-TIRA 219
Query: 1037 HTALSPLQFRG-TPGRGSSPASP-----VYSSSD--TVACHLTHTVPC-----AHQKPIT 1083
LS Q R RGS VYS S TV C L T C AH++ ++
Sbjct: 220 WDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVS 279
Query: 1084 ALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAIC 1143
ALK AG L TGS D R F + +GH+ I + + VL + DGA+
Sbjct: 280 ALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQV-HGQVLYTASHDGALR 338
Query: 1144 LWDV 1147
LWDV
Sbjct: 339 LWDV 342
Score = 52.4 bits (124), Expect = 3e-06
Identities = 42/162 (25%), Positives = 59/162 (36%), Gaps = 17/162 (10%)
Query: 1091 RLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTG 1150
RL+TGS+D T R++ D C LQGH +T ++ D I WDVLTG
Sbjct: 29 RLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSA-DCTIRRWDVLTG 87
Query: 1151 SRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLG--- 1207
+ H V + + + SS D +W G + C +L
Sbjct: 88 QCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSA 147
Query: 1208 ------------VISDNLLVTGG-QGCVSFWDLNYGDLLQTV 1236
+ LLVTG G W + G QT+
Sbjct: 148 PWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
Score = 33.1 bits (74), Expect = 1.7
Identities = 40/196 (20%), Positives = 74/196 (37%), Gaps = 27/196 (13%)
Query: 1059 VYSSSDTVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGH 1118
++S++D C L H+ +T + T S D T+R + + CL +GH
Sbjct: 41 LWSTADGQCCALLQ----GHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGH 96
Query: 1119 SGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTC-------TTS 1171
+ + + + L S D +W V G HR V +L +T
Sbjct: 97 TSIVNRILVANNQ-LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTP 155
Query: 1172 C---------VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISD---NLLVTGG- 1218
C +++ D +W ++G +++ GA L ++ D + TG
Sbjct: 156 CAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGH--TGAVLCLVLDTPGHTAFTGST 213
Query: 1219 QGCVSFWDLNYGDLLQ 1234
+ WD+ G+ L+
Sbjct: 214 DATIRAWDILSGEQLR 229
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo
sapiens]
Length = 1332
Score = 74.3 bits (181), Expect = 7e-13
Identities = 54/192 (28%), Positives = 98/192 (51%), Gaps = 17/192 (8%)
Query: 283 AELIPL-VTTYIILFAYI------YFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCT 335
AE +P+ T+YI++F YI Y S ++ MV SK L L V VL +++ ++G +
Sbjct: 630 AEDLPIFATSYIVIFLYISLALGSYSSWSRV-MVDSKATLGLGGVAVVLGAVMAAMGFFS 688
Query: 336 LFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTP--VDLEVKLRIAQGLSSESWSIM 393
G+ +L ++ P+LV+ +G +N+ + P ++ I + L + S++
Sbjct: 689 YLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSML 748
Query: 394 KNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN 453
+E +G T +PA++ F L + + ++ DF LQM F +LS+D +R E + L+
Sbjct: 749 LCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLD 808
Query: 454 -------KRLPP 458
+ LPP
Sbjct: 809 VCCCVKPQELPP 820
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo
sapiens]
Length = 1359
Score = 74.3 bits (181), Expect = 7e-13
Identities = 54/192 (28%), Positives = 98/192 (51%), Gaps = 17/192 (8%)
Query: 283 AELIPL-VTTYIILFAYI------YFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCT 335
AE +P+ T+YI++F YI Y S ++ MV SK L L V VL +++ ++G +
Sbjct: 630 AEDLPIFATSYIVIFLYISLALGSYSSWSRV-MVDSKATLGLGGVAVVLGAVMAAMGFFS 688
Query: 336 LFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTP--VDLEVKLRIAQGLSSESWSIM 393
G+ +L ++ P+LV+ +G +N+ + P ++ I + L + S++
Sbjct: 689 YLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSML 748
Query: 394 KNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN 453
+E +G T +PA++ F L + + ++ DF LQM F +LS+D +R E + L+
Sbjct: 749 LCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLD 808
Query: 454 -------KRLPP 458
+ LPP
Sbjct: 809 VCCCVKPQELPP 820
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 72.8 bits (177), Expect = 2e-12
Identities = 43/173 (24%), Positives = 84/173 (48%), Gaps = 3/173 (1%)
Query: 274 VHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGL 333
+H E+ A + V Y+++ AY + + D +S+ + LA V+ V ++ +GL
Sbjct: 387 LHAFSEVSAARV---VGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGL 443
Query: 334 CTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIM 393
C L G+T ++ P+L + IG+++V +L + ++ R+ + L S++
Sbjct: 444 CALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVV 503
Query: 394 KNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRR 446
+ L+ +PA++ F L A + + F ML F +LS+D+RR
Sbjct: 504 LTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRR 556
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 70.9 bits (172), Expect = 8e-12
Identities = 55/194 (28%), Positives = 90/194 (46%), Gaps = 8/194 (4%)
Query: 1084 ALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAI 1142
A + + RLV+ S D TL+++ + CL TL+GHS + + + ++ SG D +
Sbjct: 90 AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETV 149
Query: 1143 CLWDVLTGSRVSHVFAHRGDVTSL--TCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDL 1200
+W+V TG + + AH V+++ C+ S ++S D L IWD ++G ++ D
Sbjct: 150 KIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDD 209
Query: 1201 GCGASLGVISDN---LLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAA 1257
S S N +L + WD + G L+T KN + V
Sbjct: 210 NPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKW 269
Query: 1258 IVCNFGSELSLVYV 1271
IV GSE +LVY+
Sbjct: 270 IVS--GSEDNLVYI 281
Score = 52.4 bits (124), Expect = 3e-06
Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 19/157 (12%)
Query: 1092 LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYID-QTMVLASGGQDGAICLWDVLTG 1150
+++GS D T++++ ++ CL TL HS ++ V+ + ++ SG DG +WD +G
Sbjct: 140 IISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG 199
Query: 1151 SRVSHVFAHRGDVTS---LTCTTSCVISSGLDDLISIWDRSTG--IKFYSIQQDLGCGAS 1205
+ + S + ++++ LD+ + +WD S G +K Y+ G
Sbjct: 200 QCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT-----GHKNE 254
Query: 1206 LGVISDNLLVTGGQGCVS--------FWDLNYGDLLQ 1234
I N VTGG+ VS W+L +++Q
Sbjct: 255 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 291
Score = 36.6 bits (83), Expect = 0.16
Identities = 31/133 (23%), Positives = 61/133 (45%), Gaps = 15/133 (11%)
Query: 1114 TLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSL--TCTT 1170
TL GH+ A+++V + LAS D I +W G ++ H +++ + + +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 1171 SCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVI------SDNLLVTGG-QGCVS 1223
S ++S+ D + +WD +G +++ G S V NL+++G V
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLK-----GHSNYVFCCNFNPPSNLIISGSFDETVK 150
Query: 1224 FWDLNYGDLLQTV 1236
W++ G L+T+
Sbjct: 151 IWEVKTGKCLKTL 163
>gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
isoform 2 [Homo sapiens]
Length = 835
Score = 70.5 bits (171), Expect = 1e-11
Identities = 54/226 (23%), Positives = 108/226 (47%), Gaps = 15/226 (6%)
Query: 276 FKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCT 335
F+E++ +++I L T I YIYF + + + SK+ L +A + T+ SS + S
Sbjct: 53 FEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFST--VV 110
Query: 336 LFGLTPTLNG-GEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMK 394
+ L L G E P+ +++I L L K +S+ EV+ IA+G++ +
Sbjct: 111 IHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTL 170
Query: 395 NMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNK 454
+ E +I +G + V ++ C F + +++++F+ M FF +S+ +EL+ ++
Sbjct: 171 DALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL---VLELSRESR 227
Query: 455 RLPPEACLPSAKPVGQPTRYERQLAVRPSTPHTITLQPSSFRNLRL 500
+P+ Q + + R L + P+ +T + +L L
Sbjct: 228 ---------EGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGL 264
>gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform
1 [Homo sapiens]
Length = 888
Score = 70.5 bits (171), Expect = 1e-11
Identities = 54/226 (23%), Positives = 108/226 (47%), Gaps = 15/226 (6%)
Query: 276 FKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCT 335
F+E++ +++I L T I YIYF + + + SK+ L +A + T+ SS + S
Sbjct: 53 FEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFST--VV 110
Query: 336 LFGLTPTLNG-GEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMK 394
+ L L G E P+ +++I L L K +S+ EV+ IA+G++ +
Sbjct: 111 IHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTL 170
Query: 395 NMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNK 454
+ E +I +G + V ++ C F + +++++F+ M FF +S+ +EL+ ++
Sbjct: 171 DALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL---VLELSRESR 227
Query: 455 RLPPEACLPSAKPVGQPTRYERQLAVRPSTPHTITLQPSSFRNLRL 500
+P+ Q + + R L + P+ +T + +L L
Sbjct: 228 ---------EGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGL 264
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 288 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 347
Query: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 348 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 407
Query: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 408 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 463
Query: 463 PS 464
S
Sbjct: 464 TS 465
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 288 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 347
Query: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 348 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 407
Query: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 408 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 463
Query: 463 PS 464
S
Sbjct: 464 TS 465
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 288 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 347
Query: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 348 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 407
Query: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 408 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 463
Query: 463 PS 464
S
Sbjct: 464 TS 465
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 288 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 347
Query: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 348 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 407
Query: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 408 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 463
Query: 463 PS 464
S
Sbjct: 464 TS 465
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 438 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 497
Query: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 498 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 557
Query: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 558 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 613
Query: 463 PS 464
S
Sbjct: 614 TS 615
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 373 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 432
Query: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 433 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 492
Query: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 493 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 548
Query: 463 PS 464
S
Sbjct: 549 TS 550
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 439 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 498
Query: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 499 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 558
Query: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 559 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 614
Query: 463 PS 464
S
Sbjct: 615 TS 616
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 69.3 bits (168), Expect = 2e-11
Identities = 55/186 (29%), Positives = 87/186 (46%), Gaps = 8/186 (4%)
Query: 1092 LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTG 1150
LV+ S D TL+++ + CL TL+GHS + + Q+ ++ SG D ++ +WDV TG
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 1151 SRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGV 1208
+ + AH V+++ S ++SS D L IWD ++G ++ D S
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 1209 ISDN---LLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSE 1265
S N +L + WD + G L+T KN + V IV GSE
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS--GSE 279
Query: 1266 LSLVYV 1271
+LVY+
Sbjct: 280 DNLVYI 285
Score = 50.1 bits (118), Expect = 1e-05
Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 19/157 (12%)
Query: 1092 LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWDVLTG 1150
+V+GS D ++R++ ++ CL TL HS ++ V+ ++ ++ S DG +WD +G
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203
Query: 1151 SRVSHVFAHRGDVTS---LTCTTSCVISSGLDDLISIWDRSTG--IKFYSIQQDLGCGAS 1205
+ + S + ++++ LD+ + +WD S G +K Y+ G
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT-----GHKNE 258
Query: 1206 LGVISDNLLVTGGQGCVS--------FWDLNYGDLLQ 1234
I N VTGG+ VS W+L +++Q
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Score = 40.8 bits (94), Expect = 0.008
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 15/134 (11%)
Query: 1113 FTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT- 1170
FTL GH+ A+++V + LAS D I +W G + H+ ++ + ++
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 1171 -SCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVI------SDNLLVTGG-QGCV 1222
+ ++S+ D + IWD S+G +++ G S V NL+V+G V
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLK-----GHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 1223 SFWDLNYGDLLQTV 1236
WD+ G L+T+
Sbjct: 154 RIWDVKTGKCLKTL 167
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 69.3 bits (168), Expect = 2e-11
Identities = 55/186 (29%), Positives = 87/186 (46%), Gaps = 8/186 (4%)
Query: 1092 LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTG 1150
LV+ S D TL+++ + CL TL+GHS + + Q+ ++ SG D ++ +WDV TG
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 1151 SRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGV 1208
+ + AH V+++ S ++SS D L IWD ++G ++ D S
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 1209 ISDN---LLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSE 1265
S N +L + WD + G L+T KN + V IV GSE
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS--GSE 279
Query: 1266 LSLVYV 1271
+LVY+
Sbjct: 280 DNLVYI 285
Score = 50.1 bits (118), Expect = 1e-05
Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 19/157 (12%)
Query: 1092 LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWDVLTG 1150
+V+GS D ++R++ ++ CL TL HS ++ V+ ++ ++ S DG +WD +G
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203
Query: 1151 SRVSHVFAHRGDVTS---LTCTTSCVISSGLDDLISIWDRSTG--IKFYSIQQDLGCGAS 1205
+ + S + ++++ LD+ + +WD S G +K Y+ G
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT-----GHKNE 258
Query: 1206 LGVISDNLLVTGGQGCVS--------FWDLNYGDLLQ 1234
I N VTGG+ VS W+L +++Q
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Score = 40.8 bits (94), Expect = 0.008
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 15/134 (11%)
Query: 1113 FTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT- 1170
FTL GH+ A+++V + LAS D I +W G + H+ ++ + ++
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 1171 -SCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVI------SDNLLVTGG-QGCV 1222
+ ++S+ D + IWD S+G +++ G S V NL+V+G V
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLK-----GHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 1223 SFWDLNYGDLLQTV 1236
WD+ G L+T+
Sbjct: 154 RIWDVKTGKCLKTL 167
>gi|4502477 beta-transducin repeat containing protein isoform 2 [Homo
sapiens]
Length = 569
Score = 65.5 bits (158), Expect = 3e-10
Identities = 56/240 (23%), Positives = 100/240 (41%), Gaps = 23/240 (9%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
GS+ L+ +I+ G S + VWD G + + + L F + +V +
Sbjct: 308 GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDR 367
Query: 1028 SLDFFSLETHTALS----PLQFRGTPGRGSSPASPVYSSS--------DTVACHLTHTVP 1075
S+ + + + T ++ + R + S+S +T C T+
Sbjct: 368 SIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLN 427
Query: 1076 CAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLAS 1135
H++ I L+ +V+GS D+T+R++ +E CL L+GH + + D ++ S
Sbjct: 428 -GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV-S 485
Query: 1136 GGQDGAICLWDVLTGSR---------VSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWD 1186
G DG I +WD++ + + H G V L ++SS DD I IWD
Sbjct: 486 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD 545
Score = 57.4 bits (137), Expect = 9e-08
Identities = 42/211 (19%), Positives = 95/211 (45%), Gaps = 20/211 (9%)
Query: 1045 FRGTPGRGSSPASPVY--------------SSSDTVACHLTHTVPCAHQ--KPITALKAA 1088
F+ P G++P + Y S+ H + C + K + L+
Sbjct: 217 FKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYD 276
Query: 1089 AGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVL 1148
++V+G +D+T++++ C L GH+G++ + D+ +++ +G D + +WDV
Sbjct: 277 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVII-TGSSDSTVRVWDVN 335
Query: 1149 TGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGV 1208
TG ++ + H V L +++ D I++WD ++ + +G A++ V
Sbjct: 336 TGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
Query: 1209 I--SDNLLVT-GGQGCVSFWDLNYGDLLQTV 1236
+ D +V+ G + W+ + + ++T+
Sbjct: 396 VDFDDKYIVSASGDRTIKVWNTSTCEFVRTL 426
Score = 47.8 bits (112), Expect = 7e-05
Identities = 41/166 (24%), Positives = 67/166 (40%), Gaps = 30/166 (18%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLE---DSCCLFTLQGHSGAITTVYIDQTMVLA 1134
H + + L+ G +VT S+D ++ V+ + D L GH A+ V D +++
Sbjct: 346 HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVS 405
Query: 1135 SGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFY 1194
+ G D I +W+ T V + H+ + L V+S D+ I +W
Sbjct: 406 ASG-DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLW--------- 455
Query: 1195 SIQQDLGCGASLGVIS-----------DNLLVTGG--QGCVSFWDL 1227
D+ CGA L V+ DN + G G + WDL
Sbjct: 456 ----DIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 497
>gi|16117783 beta-transducin repeat containing protein isoform 1 [Homo
sapiens]
Length = 605
Score = 65.5 bits (158), Expect = 3e-10
Identities = 56/240 (23%), Positives = 100/240 (41%), Gaps = 23/240 (9%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
GS+ L+ +I+ G S + VWD G + + + L F + +V +
Sbjct: 344 GSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDR 403
Query: 1028 SLDFFSLETHTALS----PLQFRGTPGRGSSPASPVYSSS--------DTVACHLTHTVP 1075
S+ + + + T ++ + R + S+S +T C T+
Sbjct: 404 SIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLN 463
Query: 1076 CAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLAS 1135
H++ I L+ +V+GS D+T+R++ +E CL L+GH + + D ++ S
Sbjct: 464 -GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV-S 521
Query: 1136 GGQDGAICLWDVLTGSR---------VSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWD 1186
G DG I +WD++ + + H G V L ++SS DD I IWD
Sbjct: 522 GAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD 581
Score = 57.4 bits (137), Expect = 9e-08
Identities = 42/211 (19%), Positives = 95/211 (45%), Gaps = 20/211 (9%)
Query: 1045 FRGTPGRGSSPASPVY--------------SSSDTVACHLTHTVPCAHQ--KPITALKAA 1088
F+ P G++P + Y S+ H + C + K + L+
Sbjct: 253 FKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYD 312
Query: 1089 AGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVL 1148
++V+G +D+T++++ C L GH+G++ + D+ +++ +G D + +WDV
Sbjct: 313 DQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVII-TGSSDSTVRVWDVN 371
Query: 1149 TGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGV 1208
TG ++ + H V L +++ D I++WD ++ + +G A++ V
Sbjct: 372 TGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
Query: 1209 I--SDNLLVT-GGQGCVSFWDLNYGDLLQTV 1236
+ D +V+ G + W+ + + ++T+
Sbjct: 432 VDFDDKYIVSASGDRTIKVWNTSTCEFVRTL 462
Score = 47.8 bits (112), Expect = 7e-05
Identities = 41/166 (24%), Positives = 67/166 (40%), Gaps = 30/166 (18%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLE---DSCCLFTLQGHSGAITTVYIDQTMVLA 1134
H + + L+ G +VT S+D ++ V+ + D L GH A+ V D +++
Sbjct: 382 HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVS 441
Query: 1135 SGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFY 1194
+ G D I +W+ T V + H+ + L V+S D+ I +W
Sbjct: 442 ASG-DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLW--------- 491
Query: 1195 SIQQDLGCGASLGVIS-----------DNLLVTGG--QGCVSFWDL 1227
D+ CGA L V+ DN + G G + WDL
Sbjct: 492 ----DIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 533
>gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo
sapiens]
Length = 542
Score = 65.1 bits (157), Expect = 4e-10
Identities = 58/240 (24%), Positives = 99/240 (41%), Gaps = 23/240 (9%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
GS+ L+ +IV G S + VWD G + + + + L F + +V +
Sbjct: 281 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 340
Query: 1028 SLDFFSLETHTALSPLQF----RGTPGRGSSPASPVYSSS--------DTVACHLTHTVP 1075
S+ + + + T ++ + R + S+S T C T+
Sbjct: 341 SIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLN 400
Query: 1076 CAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLAS 1135
H++ I L+ +V+GS D+T+R++ +E CL L+GH + + D ++ S
Sbjct: 401 -GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV-S 458
Query: 1136 GGQDGAICLWDVLTGSR---------VSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWD 1186
G DG I +WD+ + + H G V L +ISS DD I IWD
Sbjct: 459 GAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWD 518
Score = 58.9 bits (141), Expect = 3e-08
Identities = 34/162 (20%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGG 1137
+ K + L+ ++++G +D++++++ CL L GH+G++ + D+ V+ +G
Sbjct: 239 NSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER-VIVTGS 297
Query: 1138 QDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQ 1197
D + +WDV TG ++ + H V L + +++ D I++WD ++ +
Sbjct: 298 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR 357
Query: 1198 QDLGCGASLGVI--SDNLLVT-GGQGCVSFWDLNYGDLLQTV 1236
+G A++ V+ D +V+ G + W + + ++T+
Sbjct: 358 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTL 399
Score = 49.3 bits (116), Expect = 2e-05
Identities = 40/166 (24%), Positives = 68/166 (40%), Gaps = 30/166 (18%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLF---TLQGHSGAITTVYIDQTMVLA 1134
H + + L+ + G +VT S+D ++ V+ + + + L GH A+ V D +++
Sbjct: 319 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVS 378
Query: 1135 SGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFY 1194
+ G D I +W T V + H+ + L V+S D+ I +W
Sbjct: 379 ASG-DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLW--------- 428
Query: 1195 SIQQDLGCGASLGVIS-----------DNLLVTGG--QGCVSFWDL 1227
D+ CGA L V+ DN + G G + WDL
Sbjct: 429 ----DIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 470
>gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo
sapiens]
Length = 508
Score = 65.1 bits (157), Expect = 4e-10
Identities = 58/240 (24%), Positives = 99/240 (41%), Gaps = 23/240 (9%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
GS+ L+ +IV G S + VWD G + + + + L F + +V +
Sbjct: 247 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 306
Query: 1028 SLDFFSLETHTALSPLQF----RGTPGRGSSPASPVYSSS--------DTVACHLTHTVP 1075
S+ + + + T ++ + R + S+S T C T+
Sbjct: 307 SIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLN 366
Query: 1076 CAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLAS 1135
H++ I L+ +V+GS D+T+R++ +E CL L+GH + + D ++ S
Sbjct: 367 -GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV-S 424
Query: 1136 GGQDGAICLWDVLTGSR---------VSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWD 1186
G DG I +WD+ + + H G V L +ISS DD I IWD
Sbjct: 425 GAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWD 484
Score = 58.9 bits (141), Expect = 3e-08
Identities = 34/162 (20%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGG 1137
+ K + L+ ++++G +D++++++ CL L GH+G++ + D+ V+ +G
Sbjct: 205 NSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER-VIVTGS 263
Query: 1138 QDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQ 1197
D + +WDV TG ++ + H V L + +++ D I++WD ++ +
Sbjct: 264 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR 323
Query: 1198 QDLGCGASLGVI--SDNLLVT-GGQGCVSFWDLNYGDLLQTV 1236
+G A++ V+ D +V+ G + W + + ++T+
Sbjct: 324 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTL 365
Score = 49.3 bits (116), Expect = 2e-05
Identities = 40/166 (24%), Positives = 68/166 (40%), Gaps = 30/166 (18%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLF---TLQGHSGAITTVYIDQTMVLA 1134
H + + L+ + G +VT S+D ++ V+ + + + L GH A+ V D +++
Sbjct: 285 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVS 344
Query: 1135 SGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFY 1194
+ G D I +W T V + H+ + L V+S D+ I +W
Sbjct: 345 ASG-DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLW--------- 394
Query: 1195 SIQQDLGCGASLGVIS-----------DNLLVTGG--QGCVSFWDL 1227
D+ CGA L V+ DN + G G + WDL
Sbjct: 395 ----DIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 436
>gi|48928046 F-box and WD repeat domain containing 11 isoform B [Homo
sapiens]
Length = 529
Score = 65.1 bits (157), Expect = 4e-10
Identities = 58/240 (24%), Positives = 99/240 (41%), Gaps = 23/240 (9%)
Query: 968 GSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNG 1027
GS+ L+ +IV G S + VWD G + + + + L F + +V +
Sbjct: 268 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 327
Query: 1028 SLDFFSLETHTALSPLQF----RGTPGRGSSPASPVYSSS--------DTVACHLTHTVP 1075
S+ + + + T ++ + R + S+S T C T+
Sbjct: 328 SIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLN 387
Query: 1076 CAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLAS 1135
H++ I L+ +V+GS D+T+R++ +E CL L+GH + + D ++ S
Sbjct: 388 -GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV-S 445
Query: 1136 GGQDGAICLWDVLTGSR---------VSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWD 1186
G DG I +WD+ + + H G V L +ISS DD I IWD
Sbjct: 446 GAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWD 505
Score = 58.9 bits (141), Expect = 3e-08
Identities = 34/162 (20%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGG 1137
+ K + L+ ++++G +D++++++ CL L GH+G++ + D+ V+ +G
Sbjct: 226 NSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER-VIVTGS 284
Query: 1138 QDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQ 1197
D + +WDV TG ++ + H V L + +++ D I++WD ++ +
Sbjct: 285 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRR 344
Query: 1198 QDLGCGASLGVI--SDNLLVT-GGQGCVSFWDLNYGDLLQTV 1236
+G A++ V+ D +V+ G + W + + ++T+
Sbjct: 345 VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTL 386
Score = 49.3 bits (116), Expect = 2e-05
Identities = 40/166 (24%), Positives = 68/166 (40%), Gaps = 30/166 (18%)
Query: 1078 HQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLF---TLQGHSGAITTVYIDQTMVLA 1134
H + + L+ + G +VT S+D ++ V+ + + + L GH A+ V D +++
Sbjct: 306 HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVS 365
Query: 1135 SGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFY 1194
+ G D I +W T V + H+ + L V+S D+ I +W
Sbjct: 366 ASG-DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLW--------- 415
Query: 1195 SIQQDLGCGASLGVIS-----------DNLLVTGG--QGCVSFWDL 1227
D+ CGA L V+ DN + G G + WDL
Sbjct: 416 ----DIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 457
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 64.3 bits (155), Expect = 7e-10
Identities = 43/154 (27%), Positives = 73/154 (47%), Gaps = 11/154 (7%)
Query: 1091 RLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYID-QTMVLASGGQDGAICLWDVLT 1149
++ TGS D T +++ +E C T +GH+ I + + Q+ ++A+G D LWD+
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 1150 GSRVSHVFAHRGDVTSLTCTTS--CVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLG 1207
G V + H ++ SL+ TS +I+ D + +WD TG K + +G A +
Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL---IGHCAEIS 265
Query: 1208 VISDN----LLVTGGQG-CVSFWDLNYGDLLQTV 1236
S N L++TG WD G + T+
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATL 299
Score = 45.4 bits (106), Expect = 3e-04
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 3/102 (2%)
Query: 1092 LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWDVLTG 1150
++TGS D T +++ + C+ TL GH I D T ++A+ DG ++ T
Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Query: 1151 SRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTG 1190
++ + H G+++ ++ + +++ D IWD TG
Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG 377
Score = 43.9 bits (102), Expect = 0.001
Identities = 29/100 (29%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Query: 1090 GRLV-TGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDV 1147
G+L+ T S D T R+F C+ L+GH G I+ + + Q L +G D +WD
Sbjct: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Query: 1148 LTGSRVSHVFAHRGDVTS--LTCTTSCVISSGLDDLISIW 1185
TG + + H ++ S + VI+ D+ IW
Sbjct: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 40.4 bits (93), Expect = 0.011
Identities = 59/288 (20%), Positives = 108/288 (37%), Gaps = 26/288 (9%)
Query: 972 SLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDK---RIVAARLNGS 1028
+L G+ + G ++WD G + E + + A+ F + +I + +
Sbjct: 99 ALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKT 158
Query: 1029 LDFFSLETHTALSPLQFRGTPGR----GSSPASPVYS--SSDTVAC-------HLTHTVP 1075
+S+ET FRG +P S + + S DT A +T+
Sbjct: 159 CKLWSVETGKCYHT--FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 1076 CAHQKPITALK--AAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYID-QTMV 1132
H I +L + R++TGS DHT+ V+ + + L GH I++ + +
Sbjct: 217 -GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275
Query: 1133 LASGGQDGAICLWDVLTGSRVSHVFAHRGDV--TSLTCTTSCVISSGLDDLISIWDRSTG 1190
+ +G D LWD G V+ + H ++ + T + ++ D I+ +T
Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Query: 1191 IKFYSIQQDLG--CGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTV 1236
++ G S ++LL WD G LQ +
Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL 383
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 62.8 bits (151), Expect = 2e-09
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 5/128 (3%)
Query: 1065 TVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITT 1124
T+ TH AH ++A+ + +VTGS+D T+ ++ ++ L HSG IT
Sbjct: 31 TLVADFTHH---AHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITC 87
Query: 1125 VYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTS--CVISSGLDDLI 1182
+ L SG +DG IC+WD + + AH+G VT L+ S +S G D +
Sbjct: 88 LKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTL 147
Query: 1183 SIWDRSTG 1190
W+ G
Sbjct: 148 RTWNLVEG 155
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 56.6 bits (135), Expect = 1e-07
Identities = 31/96 (32%), Positives = 52/96 (54%), Gaps = 3/96 (3%)
Query: 1094 TGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSR 1152
+ S D T+R++ + + CL L+GH ++ TV + + LASGG D + LWDV +G
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 1153 VSHVFAHRGDVTS--LTCTTSCVISSGLDDLISIWD 1186
+ + HR + S + T +C+ + D + IWD
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Score = 43.9 bits (102), Expect = 0.001
Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 5/132 (3%)
Query: 1092 LVTGSQDHTLRVFRLE---DSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVL 1148
L TGS D T+ ++ L + L+GHS I+ + + +LASG D I +W
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221
Query: 1149 TGSRVSHVFAHRGDVTSLTCTTS--CVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASL 1206
T S + + H V S+ + + S+G ++ +WD +TG +++ L +
Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTC 281
Query: 1207 GVISDNLLVTGG 1218
D ++ G
Sbjct: 282 AFTPDGKILVSG 293
Score = 37.7 bits (86), Expect = 0.071
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 2/83 (2%)
Query: 1070 LTHTVPCAHQKPITAL-KAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YI 1127
++H H I+ L +A+G L +GS D T+ +++ S L L+GH + ++ +
Sbjct: 183 VSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS 242
Query: 1128 DQTMVLASGGQDGAICLWDVLTG 1150
+ LAS G + +WD TG
Sbjct: 243 PDELWLASAGYSRMVKVWDCNTG 265
Score = 30.8 bits (68), Expect = 8.7
Identities = 26/122 (21%), Positives = 48/122 (39%), Gaps = 5/122 (4%)
Query: 1118 HSGAI-TTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTS--CVI 1174
H G + ++ + +L +G +DG + W+ +G + + H G V +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 1175 SSGLDDLISIWD--RSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDL 1232
S+ D + +WD R+ ++ Q S S L G V WD+ G +
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 1233 LQ 1234
L+
Sbjct: 140 LR 141
Score = 30.8 bits (68), Expect = 8.7
Identities = 17/49 (34%), Positives = 26/49 (53%), Gaps = 2/49 (4%)
Query: 763 PETEIVPLVLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWDAQTGDCL 809
P T + + L+GH+ ++ +A D + L S + V VWD TG CL
Sbjct: 220 PTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCL 268
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 55.1 bits (131), Expect = 4e-07
Identities = 39/162 (24%), Positives = 76/162 (46%), Gaps = 7/162 (4%)
Query: 1078 HQKPITALKAAAGR--LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLAS 1135
H+K + ++ A L++ S D ++V+ + C+F L+GH + + + L S
Sbjct: 959 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLS 1017
Query: 1136 GGQDGAICLWDVLTGSRVSHVFAHRGDVTS--LTCTTSCVISSGLDDLISIWDRSTGIKF 1193
DG + +W+++TG++ H+G V S ++ + S+ D IW +
Sbjct: 1018 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1077
Query: 1194 YSIQQDLGC-GASLGVISDNLLVTG-GQGCVSFWDLNYGDLL 1233
+ ++ GC S + LL TG G + W+++ G+LL
Sbjct: 1078 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1119
Score = 39.3 bits (90), Expect = 0.024
Identities = 28/116 (24%), Positives = 50/116 (43%), Gaps = 6/116 (5%)
Query: 1133 LASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTS--CVISSGLDDLISIWDRSTG 1190
+AS G D + ++ TG ++ + AH +V +T + + +D + IW+ TG
Sbjct: 630 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTG 689
Query: 1191 IKFYSI---QQDLGCGASLGVISDNLLVTGGQGC-VSFWDLNYGDLLQTVYLGKNS 1242
++ + + C LL TG C + WDLN + T++ NS
Sbjct: 690 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNS 745
Score = 35.0 bits (79), Expect = 0.46
Identities = 28/123 (22%), Positives = 49/123 (39%), Gaps = 18/123 (14%)
Query: 1076 CAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLAS 1135
C+ K + + G LV +H+ +V +CC FT H ++LA+
Sbjct: 675 CSVDKKVKIWNSMTGELVHTYDEHSEQV-----NCCHFTNSSHH-----------LLLAT 718
Query: 1136 GGQDGAICLWDVLTGSRVSHVFAHRGDVT--SLTCTTSCVISSGLDDLISIWDRSTGIKF 1193
G D + LWD+ + +F H V + + S D + +WD ++ +
Sbjct: 719 GSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANER 778
Query: 1194 YSI 1196
SI
Sbjct: 779 KSI 781
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,211,099
Number of Sequences: 37866
Number of extensions: 3303724
Number of successful extensions: 17425
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 327
Number of HSP's that attempted gapping in prelim test: 15260
Number of HSP's gapped (non-prelim): 2135
length of query: 1279
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1165
effective length of database: 13,930,794
effective search space: 16229375010
effective search space used: 16229375010
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.