Guide to the Human Genome
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Search of human proteins with 66347845

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66347845 vacuolar protein sorting 13C protein isoform 2B
[Homo sapiens]
         (3628 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66347845 vacuolar protein sorting 13C protein isoform 2B [Hom...  7119   0.0  
gi|66347828 vacuolar protein sorting 13C protein isoform 2A [Hom...  7108   0.0  
gi|66348091 vacuolar protein sorting 13C protein isoform 1B [Hom...  7007   0.0  
gi|42544121 vacuolar protein sorting 13C protein isoform 1A [Hom...  6995   0.0  
gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens]    1679   0.0  
gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens]    1679   0.0  
gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens]    1679   0.0  
gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens]    1627   0.0  
gi|54607141 vacuolar protein sorting 13D isoform 2 [Homo sapiens]     218   9e-56
gi|54607139 vacuolar protein sorting 13D isoform 1 [Homo sapiens]     218   9e-56
gi|35493713 vacuolar protein sorting 13B isoform 5 [Homo sapiens]     107   2e-22
gi|35493701 vacuolar protein sorting 13B isoform 1 [Homo sapiens]     107   2e-22
gi|119874215 vacuolar protein sorting 13B isoform 4 [Homo sapiens]     72   1e-11
gi|35493725 vacuolar protein sorting 13B isoform 3 [Homo sapiens]      72   1e-11
gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]         44   0.002
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    41   0.019
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    41   0.025
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    38   0.16 
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    38   0.21 
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    38   0.21 
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    38   0.21 
gi|55770834 centromere protein F [Homo sapiens]                        38   0.21 
gi|13699824 kinesin family member 11 [Homo sapiens]                    37   0.27 
gi|239746976 PREDICTED: similar to paraneoplastic antigen MA1 [H...    37   0.47 
gi|93204861 protein phosphatase 1, regulatory (inhibitor) subuni...    37   0.47 
gi|169217313 PREDICTED: similar to paraneoplastic antigen MA1 [H...    36   0.61 
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]              36   0.61 
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]             36   0.61 
gi|51988900 XPG-complementing protein [Homo sapiens]                   36   0.79 
gi|55749659 UHRF1 (ICBP90) binding protein 1-like isoform b [Hom...    34   2.3  

>gi|66347845 vacuolar protein sorting 13C protein isoform 2B [Homo
            sapiens]
          Length = 3628

 Score = 7119 bits (18471), Expect = 0.0
 Identities = 3628/3628 (100%), Positives = 3628/3628 (100%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD
Sbjct: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN
Sbjct: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS
Sbjct: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY
Sbjct: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK
Sbjct: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
            VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK
Sbjct: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480

Query: 481  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 540
            KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS
Sbjct: 481  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 540

Query: 541  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 600
            VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI
Sbjct: 541  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 600

Query: 601  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 660
            GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT
Sbjct: 601  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 660

Query: 661  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 720
            SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT
Sbjct: 661  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 720

Query: 721  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 780
            FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI
Sbjct: 721  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 780

Query: 781  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 840
            LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA
Sbjct: 781  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 840

Query: 841  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 900
            QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA
Sbjct: 841  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 900

Query: 901  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 960
            AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK
Sbjct: 901  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 960

Query: 961  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 1020
            KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF
Sbjct: 961  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 1020

Query: 1021 SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1080
            SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD
Sbjct: 1021 SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1080

Query: 1081 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1140
            IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK
Sbjct: 1081 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1140

Query: 1141 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1200
            TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL
Sbjct: 1141 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1200

Query: 1201 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1260
            LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN
Sbjct: 1201 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1260

Query: 1261 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1320
            AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP
Sbjct: 1261 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1320

Query: 1321 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1380
            INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK
Sbjct: 1321 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1380

Query: 1381 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1440
            VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK
Sbjct: 1381 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1440

Query: 1441 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1500
            KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV
Sbjct: 1441 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1500

Query: 1501 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1560
            TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF
Sbjct: 1501 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1560

Query: 1561 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1620
            SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA
Sbjct: 1561 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1620

Query: 1621 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1680
            DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA
Sbjct: 1621 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1680

Query: 1681 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1740
            TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA
Sbjct: 1681 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1740

Query: 1741 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1800
            ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL
Sbjct: 1741 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1800

Query: 1801 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1860
            PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK
Sbjct: 1801 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1860

Query: 1861 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1920
            GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ
Sbjct: 1861 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1920

Query: 1921 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1980
            EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS
Sbjct: 1921 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1980

Query: 1981 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 2040
            GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ
Sbjct: 1981 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 2040

Query: 2041 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2100
            IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR
Sbjct: 2041 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2100

Query: 2101 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2160
            PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP
Sbjct: 2101 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2160

Query: 2161 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2220
            FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS
Sbjct: 2161 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2220

Query: 2221 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2280
            PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV
Sbjct: 2221 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2280

Query: 2281 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2340
            ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI
Sbjct: 2281 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2340

Query: 2341 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2400
            ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN
Sbjct: 2341 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2400

Query: 2401 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2460
            NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ
Sbjct: 2401 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2460

Query: 2461 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2520
            NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA
Sbjct: 2461 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2520

Query: 2521 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2580
            SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH
Sbjct: 2521 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2580

Query: 2581 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2640
            VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN
Sbjct: 2581 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2640

Query: 2641 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2700
            TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD
Sbjct: 2641 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2700

Query: 2701 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2760
            VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI
Sbjct: 2701 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2760

Query: 2761 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2820
            GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI
Sbjct: 2761 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2820

Query: 2821 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2880
            STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL
Sbjct: 2821 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2880

Query: 2881 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2940
            ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG
Sbjct: 2881 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2940

Query: 2941 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 3000
            TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV
Sbjct: 2941 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 3000

Query: 3001 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3060
            LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR
Sbjct: 3001 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3060

Query: 3061 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3120
            VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE
Sbjct: 3061 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3120

Query: 3121 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3180
            VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK
Sbjct: 3121 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3180

Query: 3181 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3240
            RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF
Sbjct: 3181 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3240

Query: 3241 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3300
            IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI
Sbjct: 3241 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3300

Query: 3301 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3360
            QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS
Sbjct: 3301 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3360

Query: 3361 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3420
            VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL
Sbjct: 3361 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3420

Query: 3421 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3480
            DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR
Sbjct: 3421 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3480

Query: 3481 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3540
            ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV
Sbjct: 3481 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3540

Query: 3541 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3600
            EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI
Sbjct: 3541 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3600

Query: 3601 HEDGIIRPYDRQESEGSDLLEQELEIQE 3628
            HEDGIIRPYDRQESEGSDLLEQELEIQE
Sbjct: 3601 HEDGIIRPYDRQESEGSDLLEQELEIQE 3628


>gi|66347828 vacuolar protein sorting 13C protein isoform 2A [Homo
            sapiens]
          Length = 3753

 Score = 7108 bits (18441), Expect = 0.0
 Identities = 3621/3625 (99%), Positives = 3623/3625 (99%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD
Sbjct: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN
Sbjct: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS
Sbjct: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY
Sbjct: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK
Sbjct: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
            VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK
Sbjct: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480

Query: 481  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 540
            KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS
Sbjct: 481  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 540

Query: 541  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 600
            VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI
Sbjct: 541  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 600

Query: 601  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 660
            GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT
Sbjct: 601  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 660

Query: 661  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 720
            SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT
Sbjct: 661  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 720

Query: 721  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 780
            FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI
Sbjct: 721  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 780

Query: 781  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 840
            LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA
Sbjct: 781  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 840

Query: 841  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 900
            QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA
Sbjct: 841  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 900

Query: 901  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 960
            AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK
Sbjct: 901  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 960

Query: 961  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 1020
            KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF
Sbjct: 961  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 1020

Query: 1021 SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1080
            SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD
Sbjct: 1021 SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1080

Query: 1081 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1140
            IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK
Sbjct: 1081 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1140

Query: 1141 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1200
            TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL
Sbjct: 1141 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1200

Query: 1201 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1260
            LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN
Sbjct: 1201 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1260

Query: 1261 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1320
            AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP
Sbjct: 1261 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1320

Query: 1321 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1380
            INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK
Sbjct: 1321 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1380

Query: 1381 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1440
            VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK
Sbjct: 1381 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1440

Query: 1441 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1500
            KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV
Sbjct: 1441 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1500

Query: 1501 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1560
            TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF
Sbjct: 1501 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1560

Query: 1561 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1620
            SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA
Sbjct: 1561 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1620

Query: 1621 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1680
            DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA
Sbjct: 1621 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1680

Query: 1681 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1740
            TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA
Sbjct: 1681 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1740

Query: 1741 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1800
            ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL
Sbjct: 1741 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1800

Query: 1801 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1860
            PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK
Sbjct: 1801 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1860

Query: 1861 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1920
            GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ
Sbjct: 1861 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1920

Query: 1921 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1980
            EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS
Sbjct: 1921 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1980

Query: 1981 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 2040
            GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ
Sbjct: 1981 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 2040

Query: 2041 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2100
            IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR
Sbjct: 2041 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2100

Query: 2101 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2160
            PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP
Sbjct: 2101 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2160

Query: 2161 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2220
            FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS
Sbjct: 2161 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2220

Query: 2221 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2280
            PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV
Sbjct: 2221 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2280

Query: 2281 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2340
            ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI
Sbjct: 2281 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2340

Query: 2341 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2400
            ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN
Sbjct: 2341 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2400

Query: 2401 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2460
            NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ
Sbjct: 2401 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2460

Query: 2461 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2520
            NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA
Sbjct: 2461 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2520

Query: 2521 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2580
            SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH
Sbjct: 2521 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2580

Query: 2581 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2640
            VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN
Sbjct: 2581 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2640

Query: 2641 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2700
            TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD
Sbjct: 2641 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2700

Query: 2701 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2760
            VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI
Sbjct: 2701 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2760

Query: 2761 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2820
            GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI
Sbjct: 2761 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2820

Query: 2821 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2880
            STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL
Sbjct: 2821 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2880

Query: 2881 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2940
            ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG
Sbjct: 2881 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2940

Query: 2941 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 3000
            TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV
Sbjct: 2941 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 3000

Query: 3001 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3060
            LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR
Sbjct: 3001 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3060

Query: 3061 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3120
            VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE
Sbjct: 3061 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3120

Query: 3121 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3180
            VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK
Sbjct: 3121 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3180

Query: 3181 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3240
            RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF
Sbjct: 3181 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3240

Query: 3241 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3300
            IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI
Sbjct: 3241 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3300

Query: 3301 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3360
            QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS
Sbjct: 3301 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3360

Query: 3361 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3420
            VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL
Sbjct: 3361 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3420

Query: 3421 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3480
            DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR
Sbjct: 3421 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3480

Query: 3481 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3540
            ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV
Sbjct: 3481 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3540

Query: 3541 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3600
            EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI
Sbjct: 3541 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3600

Query: 3601 HEDGIIRPYDRQESEGSDLLEQELE 3625
            HEDGIIRPYDRQESEGSDLLE  ++
Sbjct: 3601 HEDGIIRPYDRQESEGSDLLENHIK 3625


>gi|66348091 vacuolar protein sorting 13C protein isoform 1B [Homo
            sapiens]
          Length = 3585

 Score = 7007 bits (18180), Expect = 0.0
 Identities = 3585/3628 (98%), Positives = 3585/3628 (98%), Gaps = 43/3628 (1%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            ALQKAAEK                                           DKPKEAKKD
Sbjct: 121  ALQKAAEK-------------------------------------------DKPKEAKKD 137

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN
Sbjct: 138  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 197

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS
Sbjct: 198  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 257

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY
Sbjct: 258  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 317

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK
Sbjct: 318  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 377

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
            VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK
Sbjct: 378  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 437

Query: 481  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 540
            KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS
Sbjct: 438  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 497

Query: 541  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 600
            VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI
Sbjct: 498  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 557

Query: 601  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 660
            GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT
Sbjct: 558  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 617

Query: 661  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 720
            SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT
Sbjct: 618  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 677

Query: 721  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 780
            FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI
Sbjct: 678  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 737

Query: 781  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 840
            LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA
Sbjct: 738  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 797

Query: 841  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 900
            QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA
Sbjct: 798  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 857

Query: 901  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 960
            AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK
Sbjct: 858  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 917

Query: 961  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 1020
            KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF
Sbjct: 918  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 977

Query: 1021 SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1080
            SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD
Sbjct: 978  SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1037

Query: 1081 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1140
            IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK
Sbjct: 1038 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1097

Query: 1141 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1200
            TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL
Sbjct: 1098 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1157

Query: 1201 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1260
            LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN
Sbjct: 1158 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1217

Query: 1261 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1320
            AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP
Sbjct: 1218 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1277

Query: 1321 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1380
            INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK
Sbjct: 1278 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1337

Query: 1381 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1440
            VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK
Sbjct: 1338 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1397

Query: 1441 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1500
            KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV
Sbjct: 1398 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1457

Query: 1501 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1560
            TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF
Sbjct: 1458 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1517

Query: 1561 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1620
            SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA
Sbjct: 1518 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1577

Query: 1621 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1680
            DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA
Sbjct: 1578 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1637

Query: 1681 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1740
            TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA
Sbjct: 1638 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1697

Query: 1741 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1800
            ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL
Sbjct: 1698 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1757

Query: 1801 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1860
            PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK
Sbjct: 1758 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1817

Query: 1861 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1920
            GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ
Sbjct: 1818 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1877

Query: 1921 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1980
            EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS
Sbjct: 1878 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1937

Query: 1981 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 2040
            GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ
Sbjct: 1938 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 1997

Query: 2041 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2100
            IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR
Sbjct: 1998 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2057

Query: 2101 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2160
            PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP
Sbjct: 2058 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2117

Query: 2161 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2220
            FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS
Sbjct: 2118 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2177

Query: 2221 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2280
            PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV
Sbjct: 2178 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2237

Query: 2281 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2340
            ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI
Sbjct: 2238 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2297

Query: 2341 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2400
            ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN
Sbjct: 2298 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2357

Query: 2401 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2460
            NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ
Sbjct: 2358 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2417

Query: 2461 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2520
            NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA
Sbjct: 2418 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2477

Query: 2521 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2580
            SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH
Sbjct: 2478 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2537

Query: 2581 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2640
            VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN
Sbjct: 2538 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2597

Query: 2641 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2700
            TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD
Sbjct: 2598 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2657

Query: 2701 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2760
            VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI
Sbjct: 2658 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2717

Query: 2761 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2820
            GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI
Sbjct: 2718 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2777

Query: 2821 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2880
            STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL
Sbjct: 2778 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2837

Query: 2881 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2940
            ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG
Sbjct: 2838 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2897

Query: 2941 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 3000
            TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV
Sbjct: 2898 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 2957

Query: 3001 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3060
            LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR
Sbjct: 2958 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3017

Query: 3061 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3120
            VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE
Sbjct: 3018 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3077

Query: 3121 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3180
            VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK
Sbjct: 3078 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3137

Query: 3181 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3240
            RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF
Sbjct: 3138 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3197

Query: 3241 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3300
            IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI
Sbjct: 3198 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3257

Query: 3301 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3360
            QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS
Sbjct: 3258 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3317

Query: 3361 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3420
            VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL
Sbjct: 3318 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3377

Query: 3421 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3480
            DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR
Sbjct: 3378 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3437

Query: 3481 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3540
            ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV
Sbjct: 3438 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3497

Query: 3541 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3600
            EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI
Sbjct: 3498 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3557

Query: 3601 HEDGIIRPYDRQESEGSDLLEQELEIQE 3628
            HEDGIIRPYDRQESEGSDLLEQELEIQE
Sbjct: 3558 HEDGIIRPYDRQESEGSDLLEQELEIQE 3585


>gi|42544121 vacuolar protein sorting 13C protein isoform 1A [Homo
            sapiens]
          Length = 3710

 Score = 6995 bits (18150), Expect = 0.0
 Identities = 3578/3625 (98%), Positives = 3580/3625 (98%), Gaps = 43/3625 (1%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            ALQKAAEK                                           DKPKEAKKD
Sbjct: 121  ALQKAAEK-------------------------------------------DKPKEAKKD 137

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN
Sbjct: 138  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 197

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS
Sbjct: 198  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 257

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY
Sbjct: 258  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 317

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK
Sbjct: 318  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 377

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
            VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK
Sbjct: 378  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 437

Query: 481  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 540
            KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS
Sbjct: 438  KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS 497

Query: 541  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 600
            VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI
Sbjct: 498  VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI 557

Query: 601  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 660
            GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT
Sbjct: 558  GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT 617

Query: 661  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 720
            SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT
Sbjct: 618  SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT 677

Query: 721  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 780
            FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI
Sbjct: 678  FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI 737

Query: 781  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 840
            LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA
Sbjct: 738  LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA 797

Query: 841  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 900
            QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA
Sbjct: 798  QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA 857

Query: 901  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 960
            AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK
Sbjct: 858  AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK 917

Query: 961  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 1020
            KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF
Sbjct: 918  KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF 977

Query: 1021 SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1080
            SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD
Sbjct: 978  SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD 1037

Query: 1081 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1140
            IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK
Sbjct: 1038 IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1097

Query: 1141 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1200
            TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL
Sbjct: 1098 TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL 1157

Query: 1201 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1260
            LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN
Sbjct: 1158 LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN 1217

Query: 1261 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1320
            AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP
Sbjct: 1218 AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP 1277

Query: 1321 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1380
            INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK
Sbjct: 1278 INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK 1337

Query: 1381 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1440
            VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK
Sbjct: 1338 VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK 1397

Query: 1441 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1500
            KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV
Sbjct: 1398 KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV 1457

Query: 1501 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1560
            TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF
Sbjct: 1458 TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF 1517

Query: 1561 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1620
            SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA
Sbjct: 1518 SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA 1577

Query: 1621 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1680
            DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA
Sbjct: 1578 DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA 1637

Query: 1681 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1740
            TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA
Sbjct: 1638 TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA 1697

Query: 1741 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1800
            ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL
Sbjct: 1698 ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL 1757

Query: 1801 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1860
            PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK
Sbjct: 1758 PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK 1817

Query: 1861 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1920
            GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ
Sbjct: 1818 GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ 1877

Query: 1921 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1980
            EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS
Sbjct: 1878 EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS 1937

Query: 1981 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 2040
            GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ
Sbjct: 1938 GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ 1997

Query: 2041 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2100
            IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR
Sbjct: 1998 IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR 2057

Query: 2101 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2160
            PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP
Sbjct: 2058 PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP 2117

Query: 2161 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2220
            FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS
Sbjct: 2118 FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS 2177

Query: 2221 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2280
            PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV
Sbjct: 2178 PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV 2237

Query: 2281 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2340
            ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI
Sbjct: 2238 ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI 2297

Query: 2341 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2400
            ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN
Sbjct: 2298 ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN 2357

Query: 2401 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2460
            NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ
Sbjct: 2358 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ 2417

Query: 2461 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2520
            NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA
Sbjct: 2418 NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA 2477

Query: 2521 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2580
            SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH
Sbjct: 2478 SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH 2537

Query: 2581 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2640
            VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN
Sbjct: 2538 VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN 2597

Query: 2641 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2700
            TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD
Sbjct: 2598 TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD 2657

Query: 2701 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2760
            VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI
Sbjct: 2658 VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI 2717

Query: 2761 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2820
            GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI
Sbjct: 2718 GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI 2777

Query: 2821 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2880
            STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL
Sbjct: 2778 STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL 2837

Query: 2881 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2940
            ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG
Sbjct: 2838 ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG 2897

Query: 2941 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 3000
            TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV
Sbjct: 2898 TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV 2957

Query: 3001 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3060
            LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR
Sbjct: 2958 LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR 3017

Query: 3061 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3120
            VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE
Sbjct: 3018 VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE 3077

Query: 3121 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3180
            VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK
Sbjct: 3078 VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK 3137

Query: 3181 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3240
            RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF
Sbjct: 3138 RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF 3197

Query: 3241 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3300
            IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI
Sbjct: 3198 IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI 3257

Query: 3301 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3360
            QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS
Sbjct: 3258 QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS 3317

Query: 3361 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3420
            VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL
Sbjct: 3318 VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL 3377

Query: 3421 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3480
            DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR
Sbjct: 3378 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR 3437

Query: 3481 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3540
            ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV
Sbjct: 3438 ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV 3497

Query: 3541 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3600
            EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI
Sbjct: 3498 EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI 3557

Query: 3601 HEDGIIRPYDRQESEGSDLLEQELE 3625
            HEDGIIRPYDRQESEGSDLLE  ++
Sbjct: 3558 HEDGIIRPYDRQESEGSDLLENHIK 3582


>gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens]
          Length = 3095

 Score = 1679 bits (4348), Expect = 0.0
 Identities = 982/2528 (38%), Positives = 1505/2528 (59%), Gaps = 145/2528 (5%)

Query: 1188 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1239
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645

Query: 1240 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1291
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705

Query: 1292 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1334
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765

Query: 1335 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1381
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825

Query: 1382 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1425
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881

Query: 1426 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1485
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941

Query: 1486 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1545
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001

Query: 1546 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNIS-QKDVFDLKITAE 1604
            ALL+ +++L +  P SE    EK + +     E +   +K ++  +S  +D+  L+I AE
Sbjct: 1002 ALLNTINYLHNILPQSE----EKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAE 1057

Query: 1605 LNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSI 1664
            L+   +F+ DQKCNI++IKI G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I
Sbjct: 1058 LSCLQIFIQDQKCNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYI 1117

Query: 1665 LGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQT 1724
             G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ 
Sbjct: 1118 TGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQA 1177

Query: 1725 AKEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLI 1784
            AK+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI
Sbjct: 1178 AKQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLI 1237

Query: 1785 RVENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQR 1844
             + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++R
Sbjct: 1238 TMTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVER 1297

Query: 1845 NLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETV 1903
            NL   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +  
Sbjct: 1298 NLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYS 1357

Query: 1904 RVRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQES 1958
                V  ++   H       T + + ++        +L   F  + L+++LY+    Q S
Sbjct: 1358 ATSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQAS 1416

Query: 1959 GVAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRK 2018
                 + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI   
Sbjct: 1417 FTDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLT 1476

Query: 2019 NDQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKE 2078
               D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A E
Sbjct: 1477 VGFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVE 1532

Query: 2079 TQILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSL 2138
            T +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +  
Sbjct: 1533 TSV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICY 1587

Query: 2139 STSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVK 2198
              +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK
Sbjct: 1588 KGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVK 1647

Query: 2199 EFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTAT 2258
               +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     T
Sbjct: 1648 SLTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNET 1706

Query: 2259 EITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLM 2316
            E       +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+
Sbjct: 1707 EKIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLI 1762

Query: 2317 AAVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPG 2368
                 + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      
Sbjct: 1763 NLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEE 1822

Query: 2369 DDFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVK 2427
            +  +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + 
Sbjct: 1823 NYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMIL 1881

Query: 2428 NAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSF 2487
            N++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  
Sbjct: 1882 NSLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKL 1938

Query: 2488 FTLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQI 2547
            F + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI
Sbjct: 1939 FFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQI 1998

Query: 2548 KNHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTT 2607
            +NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   
Sbjct: 1999 RNHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGID 2051

Query: 2608 YISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHL 2666
            +    EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL
Sbjct: 2052 F----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHL 2107

Query: 2667 YPSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNG 2725
            +P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W  
Sbjct: 2108 WPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKS 2167

Query: 2726 HFRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQY 2784
             + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY
Sbjct: 2168 EYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQY 2227

Query: 2785 RSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPA 2844
            +++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC  
Sbjct: 2228 KADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKG 2287

Query: 2845 NNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASS 2904
              M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   
Sbjct: 2288 LKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLE 2341

Query: 2905 ECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTV 2964
            +C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTV
Sbjct: 2342 QCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTV 2401

Query: 2965 ITFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWT 3023
            ITF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W 
Sbjct: 2402 ITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWR 2461

Query: 3024 YAANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQ 3082
               + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E 
Sbjct: 2462 CRKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAEL 2519

Query: 3083 ADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQ 3140
            A+ EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+
Sbjct: 2520 AEQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLER 2579

Query: 3141 SYQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSH 3196
             ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+H
Sbjct: 2580 EFKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAH 2639

Query: 3197 QRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVL 3256
            Q S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ 
Sbjct: 2640 QSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQIS 2699

Query: 3257 QFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSM 3316
            + KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+
Sbjct: 2700 RIKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASL 2757

Query: 3317 TDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTD 3374
             D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTD
Sbjct: 2758 VDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTD 2817

Query: 3375 VDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLS 3434
            V D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  S
Sbjct: 2818 VQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFS 2877

Query: 3435 EGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITM 3494
            EGVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TM
Sbjct: 2878 EGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTM 2937

Query: 3495 DKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKG 3554
            D++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG
Sbjct: 2938 DEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKG 2997

Query: 3555 IGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQES 3614
            +GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++ 
Sbjct: 2998 VGKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDG 3056

Query: 3615 EGSDLLEQ 3622
             G+ +L++
Sbjct: 3057 TGNQMLQK 3064



 Score = 1131 bits (2926), Expect = 0.0
 Identities = 618/1396 (44%), Positives = 889/1396 (63%), Gaps = 82/1396 (5%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            A QK  ++  H  E                                           K+D
Sbjct: 121  AKQKVVDQEQHLPE-------------------------------------------KQD 137

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L  LS+ T +++W PC+ +
Sbjct: 138  TFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHD 197

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+    +P  Y ++F+PIS
Sbjct: 198  ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPIS 257

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            A+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++LLESVD M +N PYRK+
Sbjct: 258  ANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYRKF 317

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ +K YK  YK KLT  K
Sbjct: 318  KPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKK 377

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
               E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+     E   GWFS LW  
Sbjct: 378  PPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPEDNKGWFSWLWSW 437

Query: 481  KESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVST 539
             E    +++  + PET+++++TPEEK  L+ AIGYSE+  + TL K + A    + L S 
Sbjct: 438  SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSM 497

Query: 540  SVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVAS 599
            S+ +REN   PE++ I I    T + QRPGAQA+K E K++ ++ITGL      P L++S
Sbjct: 498  SIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLSS 557

Query: 600  IGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQI 659
            + D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN++VEFF+  K + L Q+
Sbjct: 558  L-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQL 616

Query: 660  TSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFG 719
            T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VPQ G     S+LL+LD G
Sbjct: 617  TAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLG 676

Query: 720  TFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPS 776
              ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL++R  + W++ R    S
Sbjct: 677  HLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDNWREARKLSVS 736

Query: 777  TMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQ 836
            T HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD+K++ ++ L+ SIP P+
Sbjct: 737  TQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKPE 796

Query: 837  KSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV----------ESESDDEYFDAEDGE 885
                  P  +VS+ +      T   LGTS +   +          E +S++E+FDA    
Sbjct: 797  ------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSEEEFFDAPCSP 850

Query: 886  -------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKE-EDTILVF 937
                   P   KS++  +L+K  +  +  +    ++FE+ +V++EF     + E +++  
Sbjct: 851  LEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVLIEFYHLVGDCELSVVEI 908

Query: 938  NVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIK 997
             V  LG E  +RT+DL   ++LK+  L   E     +KP++L+++ D    DLL +EY+K
Sbjct: 909  LVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMEDLLTLEYVK 968

Query: 998  ADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIP-SDDQSISVAKEV 1056
            A+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL  I+P S+++S  V+   
Sbjct: 969  AEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEKSAPVS--- 1025

Query: 1057 QISTEKQQKNSTLPK-AIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSS 1115
              +TE + K   + K A+  S + DII  ++ A+L+   + + ++K NI+EIKI+GLDS 
Sbjct: 1026 --TTETEDKGDVIKKLALKLSTNEDIITLQILAELSCLQIFIQDQKCNISEIKIEGLDSE 1083

Query: 1116 LSLQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMS 1175
            + ++  +  + A+L NIIV D D   ++KKAV I G EVF F +  Y DAT G  YTDM+
Sbjct: 1084 MIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYTDMN 1143

Query: 1176 KVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAATSVKDLAQR 1235
             VD  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT QAA  AAT VK+LAQR
Sbjct: 1144 VVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKELAQR 1203

Query: 1236 SFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQ 1295
            S R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++     PPVID + ++
Sbjct: 1204 SSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIK 1263

Query: 1296 LTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSL 1355
            L+++ LYR+      Y   + LL P+NLE +V RNL   WY +VP   +   L  M   L
Sbjct: 1264 LSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFIL 1323

Query: 1356 NQEDLNLLFRILTENL 1371
            +QED+  +F+ L  N+
Sbjct: 1324 SQEDITTIFKTLHGNI 1339



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 1560 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1607
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496

Query: 1608 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1663
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556

Query: 1664 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1723
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606

Query: 1724 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1772
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666

Query: 1773 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1821
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726

Query: 1822 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1878
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785

Query: 1879 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1912
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814


>gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens]
          Length = 3069

 Score = 1679 bits (4347), Expect = 0.0
 Identities = 982/2527 (38%), Positives = 1504/2527 (59%), Gaps = 145/2527 (5%)

Query: 1188 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1239
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645

Query: 1240 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1291
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705

Query: 1292 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1334
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765

Query: 1335 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1381
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825

Query: 1382 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1425
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881

Query: 1426 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1485
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941

Query: 1486 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1545
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001

Query: 1546 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNIS-QKDVFDLKITAE 1604
            ALL+ +++L +  P SE    EK + +     E +   +K ++  +S  +D+  L+I AE
Sbjct: 1002 ALLNTINYLHNILPQSE----EKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAE 1057

Query: 1605 LNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSI 1664
            L+   +F+ DQKCNI++IKI G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I
Sbjct: 1058 LSCLQIFIQDQKCNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYI 1117

Query: 1665 LGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQT 1724
             G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ 
Sbjct: 1118 TGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQA 1177

Query: 1725 AKEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLI 1784
            AK+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI
Sbjct: 1178 AKQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLI 1237

Query: 1785 RVENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQR 1844
             + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++R
Sbjct: 1238 TMTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVER 1297

Query: 1845 NLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETV 1903
            NL   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +  
Sbjct: 1298 NLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYS 1357

Query: 1904 RVRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQES 1958
                V  ++   H       T + + ++        +L   F  + L+++LY+    Q S
Sbjct: 1358 ATSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQAS 1416

Query: 1959 GVAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRK 2018
                 + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI   
Sbjct: 1417 FTDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLT 1476

Query: 2019 NDQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKE 2078
               D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A E
Sbjct: 1477 VGFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVE 1532

Query: 2079 TQILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSL 2138
            T +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +  
Sbjct: 1533 TSV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICY 1587

Query: 2139 STSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVK 2198
              +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK
Sbjct: 1588 KGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVK 1647

Query: 2199 EFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTAT 2258
               +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     T
Sbjct: 1648 SLTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNET 1706

Query: 2259 EITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLM 2316
            E       +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+
Sbjct: 1707 EKIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLI 1762

Query: 2317 AAVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPG 2368
                 + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      
Sbjct: 1763 NLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEE 1822

Query: 2369 DDFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVK 2427
            +  +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + 
Sbjct: 1823 NYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMIL 1881

Query: 2428 NAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSF 2487
            N++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  
Sbjct: 1882 NSLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKL 1938

Query: 2488 FTLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQI 2547
            F + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI
Sbjct: 1939 FFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQI 1998

Query: 2548 KNHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTT 2607
            +NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   
Sbjct: 1999 RNHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGID 2051

Query: 2608 YISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHL 2666
            +    EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL
Sbjct: 2052 F----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHL 2107

Query: 2667 YPSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNG 2725
            +P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W  
Sbjct: 2108 WPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKS 2167

Query: 2726 HFRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQY 2784
             + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY
Sbjct: 2168 EYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQY 2227

Query: 2785 RSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPA 2844
            +++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC  
Sbjct: 2228 KADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKG 2287

Query: 2845 NNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASS 2904
              M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   
Sbjct: 2288 LKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLE 2341

Query: 2905 ECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTV 2964
            +C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTV
Sbjct: 2342 QCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTV 2401

Query: 2965 ITFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWT 3023
            ITF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W 
Sbjct: 2402 ITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWR 2461

Query: 3024 YAANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQ 3082
               + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E 
Sbjct: 2462 CRKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAEL 2519

Query: 3083 ADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQ 3140
            A+ EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+
Sbjct: 2520 AEQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLER 2579

Query: 3141 SYQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSH 3196
             ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+H
Sbjct: 2580 EFKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAH 2639

Query: 3197 QRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVL 3256
            Q S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ 
Sbjct: 2640 QSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQIS 2699

Query: 3257 QFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSM 3316
            + KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+
Sbjct: 2700 RIKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASL 2757

Query: 3317 TDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTD 3374
             D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTD
Sbjct: 2758 VDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTD 2817

Query: 3375 VDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLS 3434
            V D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  S
Sbjct: 2818 VQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFS 2877

Query: 3435 EGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITM 3494
            EGVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TM
Sbjct: 2878 EGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTM 2937

Query: 3495 DKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKG 3554
            D++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG
Sbjct: 2938 DEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKG 2997

Query: 3555 IGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQES 3614
            +GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++ 
Sbjct: 2998 VGKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDG 3056

Query: 3615 EGSDLLE 3621
             G+ +L+
Sbjct: 3057 TGNQMLQ 3063



 Score = 1131 bits (2926), Expect = 0.0
 Identities = 618/1396 (44%), Positives = 889/1396 (63%), Gaps = 82/1396 (5%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            A QK  ++  H  E                                           K+D
Sbjct: 121  AKQKVVDQEQHLPE-------------------------------------------KQD 137

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L  LS+ T +++W PC+ +
Sbjct: 138  TFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHD 197

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+    +P  Y ++F+PIS
Sbjct: 198  ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPIS 257

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            A+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++LLESVD M +N PYRK+
Sbjct: 258  ANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYRKF 317

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ +K YK  YK KLT  K
Sbjct: 318  KPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKK 377

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
               E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+     E   GWFS LW  
Sbjct: 378  PPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPEDNKGWFSWLWSW 437

Query: 481  KESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVST 539
             E    +++  + PET+++++TPEEK  L+ AIGYSE+  + TL K + A    + L S 
Sbjct: 438  SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSM 497

Query: 540  SVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVAS 599
            S+ +REN   PE++ I I    T + QRPGAQA+K E K++ ++ITGL      P L++S
Sbjct: 498  SIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLSS 557

Query: 600  IGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQI 659
            + D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN++VEFF+  K + L Q+
Sbjct: 558  L-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQL 616

Query: 660  TSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFG 719
            T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VPQ G     S+LL+LD G
Sbjct: 617  TAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLG 676

Query: 720  TFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPS 776
              ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL++R  + W++ R    S
Sbjct: 677  HLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDNWREARKLSVS 736

Query: 777  TMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQ 836
            T HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD+K++ ++ L+ SIP P+
Sbjct: 737  TQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKPE 796

Query: 837  KSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV----------ESESDDEYFDAEDGE 885
                  P  +VS+ +      T   LGTS +   +          E +S++E+FDA    
Sbjct: 797  ------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSEEEFFDAPCSP 850

Query: 886  -------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKE-EDTILVF 937
                   P   KS++  +L+K  +  +  +    ++FE+ +V++EF     + E +++  
Sbjct: 851  LEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVLIEFYHLVGDCELSVVEI 908

Query: 938  NVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIK 997
             V  LG E  +RT+DL   ++LK+  L   E     +KP++L+++ D    DLL +EY+K
Sbjct: 909  LVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMEDLLTLEYVK 968

Query: 998  ADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIP-SDDQSISVAKEV 1056
            A+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL  I+P S+++S  V+   
Sbjct: 969  AEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEKSAPVS--- 1025

Query: 1057 QISTEKQQKNSTLPK-AIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSS 1115
              +TE + K   + K A+  S + DII  ++ A+L+   + + ++K NI+EIKI+GLDS 
Sbjct: 1026 --TTETEDKGDVIKKLALKLSTNEDIITLQILAELSCLQIFIQDQKCNISEIKIEGLDSE 1083

Query: 1116 LSLQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMS 1175
            + ++  +  + A+L NIIV D D   ++KKAV I G EVF F +  Y DAT G  YTDM+
Sbjct: 1084 MIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYTDMN 1143

Query: 1176 KVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAATSVKDLAQR 1235
             VD  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT QAA  AAT VK+LAQR
Sbjct: 1144 VVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKELAQR 1203

Query: 1236 SFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQ 1295
            S R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++     PPVID + ++
Sbjct: 1204 SSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIK 1263

Query: 1296 LTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSL 1355
            L+++ LYR+      Y   + LL P+NLE +V RNL   WY +VP   +   L  M   L
Sbjct: 1264 LSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFIL 1323

Query: 1356 NQEDLNLLFRILTENL 1371
            +QED+  +F+ L  N+
Sbjct: 1324 SQEDITTIFKTLHGNI 1339



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 1560 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1607
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496

Query: 1608 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1663
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556

Query: 1664 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1723
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606

Query: 1724 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1772
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666

Query: 1773 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1821
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726

Query: 1822 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1878
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785

Query: 1879 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1912
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814


>gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens]
          Length = 3174

 Score = 1679 bits (4347), Expect = 0.0
 Identities = 982/2527 (38%), Positives = 1504/2527 (59%), Gaps = 145/2527 (5%)

Query: 1188 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1239
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645

Query: 1240 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1291
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705

Query: 1292 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1334
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765

Query: 1335 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1381
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825

Query: 1382 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1425
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881

Query: 1426 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1485
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941

Query: 1486 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1545
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001

Query: 1546 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNIS-QKDVFDLKITAE 1604
            ALL+ +++L +  P SE    EK + +     E +   +K ++  +S  +D+  L+I AE
Sbjct: 1002 ALLNTINYLHNILPQSE----EKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAE 1057

Query: 1605 LNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSI 1664
            L+   +F+ DQKCNI++IKI G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I
Sbjct: 1058 LSCLQIFIQDQKCNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYI 1117

Query: 1665 LGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQT 1724
             G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ 
Sbjct: 1118 TGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQA 1177

Query: 1725 AKEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLI 1784
            AK+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI
Sbjct: 1178 AKQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLI 1237

Query: 1785 RVENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQR 1844
             + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++R
Sbjct: 1238 TMTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVER 1297

Query: 1845 NLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETV 1903
            NL   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +  
Sbjct: 1298 NLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYS 1357

Query: 1904 RVRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQES 1958
                V  ++   H       T + + ++        +L   F  + L+++LY+    Q S
Sbjct: 1358 ATSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQAS 1416

Query: 1959 GVAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRK 2018
                 + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI   
Sbjct: 1417 FTDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLT 1476

Query: 2019 NDQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKE 2078
               D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A E
Sbjct: 1477 VGFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVE 1532

Query: 2079 TQILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSL 2138
            T +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +  
Sbjct: 1533 TSV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICY 1587

Query: 2139 STSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVK 2198
              +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK
Sbjct: 1588 KGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVK 1647

Query: 2199 EFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTAT 2258
               +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     T
Sbjct: 1648 SLTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNET 1706

Query: 2259 EITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLM 2316
            E       +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+
Sbjct: 1707 EKIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLI 1762

Query: 2317 AAVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPG 2368
                 + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      
Sbjct: 1763 NLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEE 1822

Query: 2369 DDFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVK 2427
            +  +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + 
Sbjct: 1823 NYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMIL 1881

Query: 2428 NAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSF 2487
            N++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  
Sbjct: 1882 NSLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKL 1938

Query: 2488 FTLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQI 2547
            F + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI
Sbjct: 1939 FFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQI 1998

Query: 2548 KNHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTT 2607
            +NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   
Sbjct: 1999 RNHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGID 2051

Query: 2608 YISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHL 2666
            +    EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL
Sbjct: 2052 F----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHL 2107

Query: 2667 YPSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNG 2725
            +P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W  
Sbjct: 2108 WPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKS 2167

Query: 2726 HFRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQY 2784
             + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY
Sbjct: 2168 EYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQY 2227

Query: 2785 RSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPA 2844
            +++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC  
Sbjct: 2228 KADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKG 2287

Query: 2845 NNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASS 2904
              M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   
Sbjct: 2288 LKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLE 2341

Query: 2905 ECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTV 2964
            +C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTV
Sbjct: 2342 QCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTV 2401

Query: 2965 ITFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWT 3023
            ITF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W 
Sbjct: 2402 ITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWR 2461

Query: 3024 YAANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQ 3082
               + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E 
Sbjct: 2462 CRKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAEL 2519

Query: 3083 ADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQ 3140
            A+ EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+
Sbjct: 2520 AEQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLER 2579

Query: 3141 SYQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSH 3196
             ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+H
Sbjct: 2580 EFKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAH 2639

Query: 3197 QRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVL 3256
            Q S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ 
Sbjct: 2640 QSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQIS 2699

Query: 3257 QFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSM 3316
            + KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+
Sbjct: 2700 RIKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASL 2757

Query: 3317 TDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTD 3374
             D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTD
Sbjct: 2758 VDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTD 2817

Query: 3375 VDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLS 3434
            V D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  S
Sbjct: 2818 VQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFS 2877

Query: 3435 EGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITM 3494
            EGVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TM
Sbjct: 2878 EGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTM 2937

Query: 3495 DKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKG 3554
            D++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG
Sbjct: 2938 DEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKG 2997

Query: 3555 IGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQES 3614
            +GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++ 
Sbjct: 2998 VGKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDG 3056

Query: 3615 EGSDLLE 3621
             G+ +L+
Sbjct: 3057 TGNQMLQ 3063



 Score = 1131 bits (2926), Expect = 0.0
 Identities = 618/1396 (44%), Positives = 889/1396 (63%), Gaps = 82/1396 (5%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            A QK  ++  H  E                                           K+D
Sbjct: 121  AKQKVVDQEQHLPE-------------------------------------------KQD 137

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L  LS+ T +++W PC+ +
Sbjct: 138  TFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHD 197

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+    +P  Y ++F+PIS
Sbjct: 198  ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPIS 257

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            A+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++LLESVD M +N PYRK+
Sbjct: 258  ANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYRKF 317

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ +K YK  YK KLT  K
Sbjct: 318  KPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKK 377

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
               E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+     E   GWFS LW  
Sbjct: 378  PPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPEDNKGWFSWLWSW 437

Query: 481  KESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVST 539
             E    +++  + PET+++++TPEEK  L+ AIGYSE+  + TL K + A    + L S 
Sbjct: 438  SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSM 497

Query: 540  SVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVAS 599
            S+ +REN   PE++ I I    T + QRPGAQA+K E K++ ++ITGL      P L++S
Sbjct: 498  SIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLSS 557

Query: 600  IGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQI 659
            + D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN++VEFF+  K + L Q+
Sbjct: 558  L-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQL 616

Query: 660  TSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFG 719
            T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VPQ G     S+LL+LD G
Sbjct: 617  TAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLG 676

Query: 720  TFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPS 776
              ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL++R  + W++ R    S
Sbjct: 677  HLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDNWREARKLSVS 736

Query: 777  TMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQ 836
            T HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD+K++ ++ L+ SIP P+
Sbjct: 737  TQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKPE 796

Query: 837  KSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV----------ESESDDEYFDAEDGE 885
                  P  +VS+ +      T   LGTS +   +          E +S++E+FDA    
Sbjct: 797  ------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSEEEFFDAPCSP 850

Query: 886  -------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKE-EDTILVF 937
                   P   KS++  +L+K  +  +  +    ++FE+ +V++EF     + E +++  
Sbjct: 851  LEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVLIEFYHLVGDCELSVVEI 908

Query: 938  NVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIK 997
             V  LG E  +RT+DL   ++LK+  L   E     +KP++L+++ D    DLL +EY+K
Sbjct: 909  LVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMEDLLTLEYVK 968

Query: 998  ADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIP-SDDQSISVAKEV 1056
            A+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL  I+P S+++S  V+   
Sbjct: 969  AEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEKSAPVS--- 1025

Query: 1057 QISTEKQQKNSTLPK-AIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSS 1115
              +TE + K   + K A+  S + DII  ++ A+L+   + + ++K NI+EIKI+GLDS 
Sbjct: 1026 --TTETEDKGDVIKKLALKLSTNEDIITLQILAELSCLQIFIQDQKCNISEIKIEGLDSE 1083

Query: 1116 LSLQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMS 1175
            + ++  +  + A+L NIIV D D   ++KKAV I G EVF F +  Y DAT G  YTDM+
Sbjct: 1084 MIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYTDMN 1143

Query: 1176 KVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAATSVKDLAQR 1235
             VD  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT QAA  AAT VK+LAQR
Sbjct: 1144 VVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKELAQR 1203

Query: 1236 SFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQ 1295
            S R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++     PPVID + ++
Sbjct: 1204 SSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIK 1263

Query: 1296 LTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSL 1355
            L+++ LYR+      Y   + LL P+NLE +V RNL   WY +VP   +   L  M   L
Sbjct: 1264 LSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFIL 1323

Query: 1356 NQEDLNLLFRILTENL 1371
            +QED+  +F+ L  N+
Sbjct: 1324 SQEDITTIFKTLHGNI 1339



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 1560 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1607
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496

Query: 1608 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1663
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556

Query: 1664 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1723
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606

Query: 1724 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1772
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666

Query: 1773 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1821
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726

Query: 1822 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1878
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785

Query: 1879 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1912
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814


>gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens]
          Length = 3135

 Score = 1627 bits (4214), Expect = 0.0
 Identities = 968/2526 (38%), Positives = 1477/2526 (58%), Gaps = 182/2526 (7%)

Query: 1188 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1239
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645

Query: 1240 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1291
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705

Query: 1292 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1334
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765

Query: 1335 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1381
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825

Query: 1382 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1425
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881

Query: 1426 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1485
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941

Query: 1486 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1545
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001

Query: 1546 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAEL 1605
            ALL+ +++L +  P SE  S                    A  S    +D  D+      
Sbjct: 1002 ALLNTINYLHNILPQSEEKS--------------------APVSTTETEDKGDV------ 1035

Query: 1606 NAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSIL 1665
                            IK  G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I 
Sbjct: 1036 ----------------IKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYIT 1079

Query: 1666 GDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1725
            G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ A
Sbjct: 1080 GKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAA 1139

Query: 1726 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1785
            K+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI 
Sbjct: 1140 KQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLIT 1199

Query: 1786 VENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRN 1845
            + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++RN
Sbjct: 1200 MTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERN 1259

Query: 1846 LAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETVR 1904
            L   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +   
Sbjct: 1260 LCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSA 1319

Query: 1905 VRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQESG 1959
               V  ++   H       T + + ++        +L   F  + L+++LY+    Q S 
Sbjct: 1320 TSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASF 1378

Query: 1960 VAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKN 2019
                + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI    
Sbjct: 1379 TDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTV 1438

Query: 2020 DQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKET 2079
              D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A ET
Sbjct: 1439 GFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVET 1494

Query: 2080 QILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLS 2139
             +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +   
Sbjct: 1495 SV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYK 1549

Query: 2140 TSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKE 2199
             +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK 
Sbjct: 1550 GNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKS 1609

Query: 2200 FIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATE 2259
              +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     TE
Sbjct: 1610 LTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETE 1668

Query: 2260 ITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMA 2317
                   +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+ 
Sbjct: 1669 KIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLIN 1724

Query: 2318 AVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPGD 2369
                + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      +
Sbjct: 1725 LHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEEN 1784

Query: 2370 DFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVKN 2428
              +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + N
Sbjct: 1785 YKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMILN 1843

Query: 2429 AVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSFF 2488
            ++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  F
Sbjct: 1844 SLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKLF 1900

Query: 2489 TLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQIK 2548
             + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI+
Sbjct: 1901 FILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIR 1960

Query: 2549 NHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTTY 2608
            NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   +
Sbjct: 1961 NHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGIDF 2013

Query: 2609 ISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHLY 2667
                EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL+
Sbjct: 2014 ----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHLW 2069

Query: 2668 PSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNGH 2726
            P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W   
Sbjct: 2070 PPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKSE 2129

Query: 2727 FRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQYR 2785
            + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY+
Sbjct: 2130 YHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQYK 2189

Query: 2786 SEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPAN 2845
            ++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC   
Sbjct: 2190 ADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKGL 2249

Query: 2846 NMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASSE 2905
             M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   +
Sbjct: 2250 KMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLEQ 2303

Query: 2906 CLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTVI 2965
            C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTVI
Sbjct: 2304 CIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTVI 2363

Query: 2966 TFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWTY 3024
            TF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W  
Sbjct: 2364 TFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWRC 2423

Query: 3025 AANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQA 3083
              + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E A
Sbjct: 2424 RKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481

Query: 3084 DYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQS 3141
            + EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+ 
Sbjct: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541

Query: 3142 YQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSHQ 3197
            ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+HQ
Sbjct: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601

Query: 3198 RSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQ 3257
             S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ +
Sbjct: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661

Query: 3258 FKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSMT 3317
             KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+ 
Sbjct: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASLV 2719

Query: 3318 DMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTDV 3375
            D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTDV
Sbjct: 2720 DQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDV 2779

Query: 3376 DDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSE 3435
             D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  SE
Sbjct: 2780 QDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSE 2839

Query: 3436 GVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMD 3495
            GVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TMD
Sbjct: 2840 GVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMD 2899

Query: 3496 KEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGI 3555
            ++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG+
Sbjct: 2900 EDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGV 2959

Query: 3556 GKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQESE 3615
            GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++  
Sbjct: 2960 GKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDGT 3018

Query: 3616 GSDLLE 3621
            G+ +L+
Sbjct: 3019 GNQMLQ 3024



 Score = 1090 bits (2820), Expect = 0.0
 Identities = 603/1394 (43%), Positives = 863/1394 (61%), Gaps = 117/1394 (8%)

Query: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
            A QK  ++  H  E                                           K+D
Sbjct: 121  AKQKVVDQEQHLPE-------------------------------------------KQD 137

Query: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240
            TF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L  LS+ T +++W PC+ +
Sbjct: 138  TFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHD 197

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300
            E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+    +P  Y ++F+PIS
Sbjct: 198  ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPIS 257

Query: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360
            A+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++LLESVD M +N PYRK+
Sbjct: 258  ANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYRKF 317

Query: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420
            KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ +K YK  YK KLT  K
Sbjct: 318  KPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKK 377

Query: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480
               E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+     E   GWFS LW  
Sbjct: 378  PPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPEDNKGWFSWLWSW 437

Query: 481  KESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVST 539
             E    +++  + PET+++++TPEEK  L+ AIGYSE+  + TL K + A    + L S 
Sbjct: 438  SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSM 497

Query: 540  SVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVAS 599
            S+ +REN   PE++ I I    T + QRPGAQA+K E K++ ++ITGL      P L++S
Sbjct: 498  SIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLSS 557

Query: 600  IGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQI 659
            + D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN++VEFF+  K + L Q+
Sbjct: 558  L-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQL 616

Query: 660  TSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFG 719
            T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VPQ G     S+LL+LD G
Sbjct: 617  TAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLG 676

Query: 720  TFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPS 776
              ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL++R  + W++ R    S
Sbjct: 677  HLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDNWREARKLSVS 736

Query: 777  TMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQ 836
            T HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD+K++ ++ L+ SIP P+
Sbjct: 737  TQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKPE 796

Query: 837  KSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV----------ESESDDEYFDAEDGE 885
                  P  +VS+ +      T   LGTS +   +          E +S++E+FDA    
Sbjct: 797  ------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSEEEFFDAPCSP 850

Query: 886  -------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKE-EDTILVF 937
                   P   KS++  +L+K  +  +  +    ++FE+ +V++EF     + E +++  
Sbjct: 851  LEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVLIEFYHLVGDCELSVVEI 908

Query: 938  NVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIK 997
             V  LG E  +RT+DL   ++LK+  L   E     +KP++L+++ D    DLL +EY+K
Sbjct: 909  LVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMEDLLTLEYVK 968

Query: 998  ADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQ 1057
            A+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL  I+P  ++     K   
Sbjct: 969  AEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEE-----KSAP 1023

Query: 1058 ISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLS 1117
            +ST + +                                   +K ++  IK  GLDS + 
Sbjct: 1024 VSTTETE-----------------------------------DKGDV--IKKLGLDSEMI 1046

Query: 1118 LQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKV 1177
            ++  +  + A+L NIIV D D   ++KKAV I G EVF F +  Y DAT G  YTDM+ V
Sbjct: 1047 MRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYTDMNVV 1106

Query: 1178 DGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSF 1237
            D  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT QAA  AAT VK+LAQRS 
Sbjct: 1107 DIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKELAQRSS 1166

Query: 1238 RVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLT 1297
            R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++     PPVID + ++L+
Sbjct: 1167 RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIKLS 1226

Query: 1298 KLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQ 1357
            ++ LYR+      Y   + LL P+NLE +V RNL   WY +VP   +   L  M   L+Q
Sbjct: 1227 EMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQ 1286

Query: 1358 EDLNLLFRILTENL 1371
            ED+  +F+ L  N+
Sbjct: 1287 EDITTIFKTLHGNI 1300



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 1560 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1607
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496

Query: 1608 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1663
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556

Query: 1664 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1723
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606

Query: 1724 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1772
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666

Query: 1773 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1821
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726

Query: 1822 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1878
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785

Query: 1879 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1912
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814



 Score = 33.5 bits (75), Expect = 3.9
 Identities = 61/330 (18%), Positives = 128/330 (38%), Gaps = 36/330 (10%)

Query: 538  STSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLV 597
            S  V+  E ++  +++K   +GL +++  RP     ++ AKL +  +       I    V
Sbjct: 1021 SAPVSTTETEDKGDVIKK--LGLDSEMIMRPSET--EINAKLRNIIVLDSDITAIYKKAV 1076

Query: 598  ASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQP------VEVIYDAKTVNAVVEF---F 648
               G    S   + +      S      +V  Q       +EV++  K + +++ F   F
Sbjct: 1077 YITGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNF 1136

Query: 649  QSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHH 708
            Q+ K    E    A  M         ATG+  + +    + L IN+K   +V+PQ+    
Sbjct: 1137 QAAKQALAEATVQAAGM--------AATGVKELAQRSSRMALDINIKAPVVVIPQSPV-- 1186

Query: 709  EKSDLLILDFGTFQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWK 768
               ++ + DFG   + +    + ++ +S    I     D   +++  ++L  +R      
Sbjct: 1187 -SENVFVADFGLITMTNTFHMITESQSSPPPVI-----DLITIKLSEMRLYRSRF----- 1235

Query: 769  KCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISDQKMKDVLY 827
                 +   + +L P+++ V + + +  E    +  F V+  L  M   +S + +  +  
Sbjct: 1236 -INDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFK 1294

Query: 828  LMNSIPLPQKSSAQSPERQVSSIPIISGGT 857
             ++     +K  + SP          SG T
Sbjct: 1295 TLHGNIWYEKDGSASPAVTKDQYSATSGVT 1324


>gi|54607141 vacuolar protein sorting 13D isoform 2 [Homo sapiens]
          Length = 4363

 Score =  218 bits (555), Expect = 9e-56
 Identities = 320/1522 (21%), Positives = 604/1522 (39%), Gaps = 311/1522 (20%)

Query: 2    VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQ 61
            +LE +VA +LN +LG YV NLN  QL + +  G V L+NL +K++AL EL++PF+VKAG 
Sbjct: 1    MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60

Query: 62   IDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEA 121
            I K+TL+IP+   + +  V ++  L+L+   GA  K     +EK     K  E  R +  
Sbjct: 61   IGKVTLQIPFYRPHVDPWVISISSLHLI---GAPEKIQDFNDEKE----KLLERERKKAL 113

Query: 122  LQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKDT 181
            LQ   EK                   K  R++K     +                    +
Sbjct: 114  LQALEEKW------------------KNDRQQKGESYWY--------------------S 135

Query: 182  FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
                + T++++N+++KI D+H+++ED VT+P  P +FG+ +  +S+  A        +NE
Sbjct: 136  VTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNA--------VNE 187

Query: 242  ADKIIYKLIRLD--SLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPI 299
              + + +  +LD    S YW+V+C++     + ++ + +   + +      ++ Y+ +P+
Sbjct: 188  PVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESR-----SHHYVLEPV 242

Query: 300  SASAKLYMNPYAESELKT---PKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAP 356
             ASA L  N  ++  L++   P++DC+I+++ I ++L++ QY  +++ L+ ++   R   
Sbjct: 243  FASALLKRN-CSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVK 301

Query: 357  YRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKL 416
            +R++KP + +  N R WW +A+++ L   IR   +  +W  +    +   SY   Y NKL
Sbjct: 302  FRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360

Query: 417  TQSKVSEEIQKEIQDLEKTLDVFNIILAR---------QQAQVEVIRSGQKLRKKSADTG 467
                +S + ++E+  +E+      + + R         Q+   E +R  Q     +    
Sbjct: 361  KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420

Query: 468  EKRGG----------WFSGLWGKKESKK------------KDEESLIPETI--------- 496
             + GG          WF G WG    ++            + +E  IPE I         
Sbjct: 421  PEPGGGSGMLQYLQSWFPG-WGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDP 479

Query: 497  ----DDLMTPEEKDKLFTAIGYSESTHNLTL-------PKQYVAHIMTL-----KLVSTS 540
                  + T  ++D +F  +        +TL       P+   +  M L     KL++ S
Sbjct: 480  TADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAES 539

Query: 541  VTIRENKNIPEILKIQIIGL--------GTQ----VSQRPGAQALKVEAKLEHWYITGLR 588
            +  R +     +L +++ GL        GT     V   P  +  +V          GL+
Sbjct: 540  LPRRNS----SLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSF------GLQ 589

Query: 589  QQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFF 648
                  S      D    + ++ +E NP  S  ++ L V ++P+ +IY+ + +  V +FF
Sbjct: 590  TTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFF 649

Query: 649  QSNK------GLDLE---QITSATLMKLEEIKERTATGLTH---------IIETRKVLDL 690
               K      G   E   ++  A   +  ++K +T   +            IE  K   +
Sbjct: 650  YKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTV 709

Query: 691  RINLKPSYLVVPQTGFHHEKSDLLILDFGTFQL-NSKDQGLQKTTNSSLEE--------- 740
            R+++    ++ P   F  +   L+++D G   L N++D   +K+ + S  E         
Sbjct: 710  RLDISAPQVIFPD-DFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEY 768

Query: 741  ----------------------------------------IMDKAYDKFDVEIKNVQLLF 760
                                                    +  K Y+++ +   ++Q++ 
Sbjct: 769  KTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMV 828

Query: 761  ARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISD 819
             R ++ WK  +       H+++  ++H++L + ++   D +     +SG LP + + I++
Sbjct: 829  GRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINE 888

Query: 820  QKMKDVLYLMNSIPLPQKSSAQSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYF 879
             K   +  L N   L      ++ + Q+          +G L  S++  T      +++ 
Sbjct: 889  DK---ISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHT 945

Query: 880  DAEDGEPQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNV 939
                 E Q   +       +     N   I++L  F        F K+  + +  L   V
Sbjct: 946  REVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTN---AHFVKRPYDAEVSL--TV 1000

Query: 940  TQLGTEATMRT----FDLTVVSYLKKISLDY--------------------HEIEGSKRK 975
              L    TM+T    FDL + S+ K +S D                     H  +G+   
Sbjct: 1001 HGLLLVDTMQTYGADFDLLMASH-KNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLN 1059

Query: 976  PLHLISSS-----DKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQ 1030
                 S S      K    L+K+EY       PS       T Q + +  ++L+++L  +
Sbjct: 1060 DRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTLQVISLQVNNLDIILNPE 1117

Query: 1031 ALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKL 1090
             +V  I +L    P +   +S    +       ++  T       + +  +   RL   L
Sbjct: 1118 TIVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLL 1177

Query: 1091 NAFCVIVCNEK--NNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPKTVHKKAVS 1148
                 +   EK    IA   I G   ++S+ S    +   L  + + D+    V  + V 
Sbjct: 1178 LRTVGMANREKYGRKIATASIGGTKVNVSMGS-TFDMNGSLGCLQLMDLTQDNVKNQYVV 1236

Query: 1149 IMGNEVFRFNL--DL---------YPDA--TEGDLYT--DMSKVDGVLSLNVGCIQIVYL 1193
             +GN V   N+  D+           DA  TE   +T  + SK +  L+L +  +   + 
Sbjct: 1237 SIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHS 1296

Query: 1194 HKFLMSLL--------NFLNNFQTAKESLSAATAQAAERAATSVK--------------- 1230
             KFL  L         NF    ++A   ++   A      +  V                
Sbjct: 1297 AKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILE 1356

Query: 1231 -------DLAQR---SFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSD 1280
                   DLA     + ++ +NI++++PV+ IP+   S   +V  LG I + N F    D
Sbjct: 1357 ENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDD 1415

Query: 1281 EDYLNPPVIDRMDVQLTKLTLY 1302
            E        DR+ V++  + LY
Sbjct: 1416 ESR-----SDRLQVEIKDIKLY 1432



 Score =  139 bits (350), Expect = 5e-32
 Identities = 117/442 (26%), Positives = 206/442 (46%), Gaps = 46/442 (10%)

Query: 3184 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDV 3243
            L+GI + + Q +    L   +  +QVDNQL G   P + + V P  +     E  P + V
Sbjct: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887

Query: 3244 SVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQD 3303
            + +   ++ +    +K+ M+  Q   ++I++  L  +++ F      E+E      +++ 
Sbjct: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFG-YDQAESE------VEKY 3940

Query: 3304 IDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHSVNL 3363
             + L+ +  E   T   I  +FE+  IS  ++ LS+        S+K   ++ A+ S   
Sbjct: 3941 DENLHEKTAEQGGTP--IRYYFENLKISIPQIKLSVFT------SNKLPLDLKALKS--- 3989

Query: 3364 LLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVL 3423
               ++G  L   +D +  L  +   + +  ++ +I  +++H+ E+ L Q   ++  +D L
Sbjct: 3990 ---TLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4046

Query: 3424 GNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITG 3483
            GNP GL+  +SEGV  L      G V G              L  +   G +   ++  G
Sbjct: 4047 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4089

Query: 3484 SVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGA 3543
            ++  GL   TMD  +Q + RE +       G+ L  G  G   G++GG+T +IT  VEG 
Sbjct: 4090 TLSDGLGK-TMDNRHQSE-REYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4147

Query: 3544 KKE-GAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAEST---EEVSSLRPPR- 3598
            K E G +GF  G+GKGLVG V +P  G +D AS T Q ++  A  +    +   +R PR 
Sbjct: 4148 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4207

Query: 3599 LIHEDGIIRPYDRQESEGSDLL 3620
                 G++  Y   ++EG + L
Sbjct: 4208 CTGPQGLLPRYSESQAEGQEQL 4229



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 65/289 (22%), Positives = 140/289 (48%), Gaps = 17/289 (5%)

Query: 990  LLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQS 1049
            L+ +     DK  P F +++ +  +++ V F+ L++L+  Q  V  +++      +D+ +
Sbjct: 1784 LVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHA 1843

Query: 1050 ISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKI 1109
            + +  E  +   K +     P A + S   D ++ +L  K+++  +++    + +A+  +
Sbjct: 1844 MRLPPEGILHNVKLE-----PHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANV 1898

Query: 1110 QGLDSSLSLQSRKQSLFARLENIIVTDVDPK-TVHKKAVSIMGNEVFRFNLDLY--PDAT 1166
              L + L +     +L   + ++ ++D+      +++  +  G E   F    Y  PD  
Sbjct: 1899 SKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPL 1958

Query: 1167 EGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAA 1226
                     + D  +SL +  +Q V+  +F   ++ F+ +F   ++ L     Q A    
Sbjct: 1959 L------RREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIEG 2009

Query: 1227 TSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQF 1275
             +V+D AQR  RV ++I+  APV++IP+SS S N +V +LG ++V N+F
Sbjct: 2010 QTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058



 Score = 82.8 bits (203), Expect = 6e-15
 Identities = 66/305 (21%), Positives = 147/305 (48%), Gaps = 20/305 (6%)

Query: 1490 EPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
            EP  ++  S   D+ L+ + +   D   PEF + ++   + + V F  LD+++ L+  + 
Sbjct: 1770 EPKILVGKSKF-DDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVV 1828

Query: 1550 FMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQ-KDVFDLKITAELNAF 1608
             +DF      F   S+++  +   P  G   ++ ++  +S  S  +D  + K+  ++++ 
Sbjct: 1829 ILDF------FGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSL 1882

Query: 1609 NVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQS-IHKKAVSILGD 1667
            ++ +      +A   +  + A + +      +   +  + + ++      +++  +  G+
Sbjct: 1883 SLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGE 1942

Query: 1668 EVFRFQLTLY--PDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1725
            E   FQ   Y  PD      +      D ++S ++  +Q V+  +F   ++ F+ +F   
Sbjct: 1943 EALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQL 1996

Query: 1726 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1785
            ++ L     Q A     +++D AQ+  R+L+DI   APV++IP+SS S N ++A+LG ++
Sbjct: 1997 QDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLK 2053

Query: 1786 VENKF 1790
            V+NKF
Sbjct: 2054 VKNKF 2058



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 96/441 (21%), Positives = 173/441 (39%), Gaps = 70/441 (15%)

Query: 2662 YIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTADVLHSRISGEIMEL-------- 2713
            + I+L P++ + NLLP  L + ++G      L  G  A  LH+  + + +EL        
Sbjct: 3151 HTIYLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEA-ALHTADTSQNIELGVSLENFP 3209

Query: 2714 ----VLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRIGSRMVLSVF 2769
                +L+    +N+    R+ D             +     + + +  R  GS  +  + 
Sbjct: 3210 LCKELLIPPGTQNYMVRMRLYDV------------NRRQLNLTIRIVCRAEGSLKIF-IS 3256

Query: 2770 SPYWLINKTTRVLQYRSEDIHVKHPADFRD--------IILFSFKKKNIFTKNKVQLKIS 2821
            +PYWLINKT   L +R ++        F +         +LF +  K     N   ++I 
Sbjct: 3257 APYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKE--QPNLCTMRIG 3314

Query: 2822 TS-------AWSSSFSLDTVGSYGCVKCPAN----NMEYLVGVSIK--MSSFNLSRIVTL 2868
                      W   FSLD       +K         + Y +G+ +K     +  + +V  
Sbjct: 3315 RGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIF 3374

Query: 2869 TPFCTIANKSSLELEVGEIA-SDGSMPTNKWNYIAS---SECLPFWPES-LSGKLCVR-- 2921
             P   + NKSS +L   +   + G    N   YI++   S  +  WP +     LCVR  
Sbjct: 3375 APRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLM 3434

Query: 2922 -VVGCEGSSKPFFYNRQDNGTLLSLEDLNGG---ILVDVNTAEHSTVITFSDYHEGSAPA 2977
             V  C  S    F   ++N   +++ D  G    + V++     +  I+FSD  +   P 
Sbjct: 3435 DVPNCIWSGG--FEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPF 3492

Query: 2978 LIMNHTPWDILTYKQSGSPEEMV---LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLL 3034
             I N +   ++ + Q G  E  +   + P  +  +AW +PT    +T T     G  ++ 
Sbjct: 3493 RIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT-VKGAGSSEI- 3549

Query: 3035 KDGCGQFPYDANIQIHWVSFL 3055
               C    +  N Q+++ +F+
Sbjct: 3550 --NCNMNDFQDNRQLYYENFI 3568



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 122/611 (19%), Positives = 236/611 (38%), Gaps = 138/611 (22%)

Query: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLL---FRILT--ENL 1371
            ++   N+   + R L  +   K P   + G+L  + + +N++ ++ L   F +LT  E  
Sbjct: 848  VVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMK 907

Query: 1372 CEGTEDLDKVKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEI 1431
               T+  +K+ P+ ++ G        S+   V +   ++    +  R V + + LL  E 
Sbjct: 908  TSDTQIKEKIFPQEEQRG--------SLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEF 959

Query: 1432 KEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYD----MTAKAYLKKISMQCF--DFT 1485
            K  V  +    E  GR +  L V         + YD    +T    L   +MQ +  DF 
Sbjct: 960  K--VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFD 1017

Query: 1486 -------------------DSKGE-PLHIINSSNVTD----------------------E 1503
                               DS+ + P+   N +++TD                      E
Sbjct: 1018 LLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQE 1077

Query: 1504 PLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPFSEP 1563
             L+K+      S+ P      DST Q + +   +LD++L+ E ++  + FL  + P  + 
Sbjct: 1078 SLIKLEYQFVSSECPSMNL--DSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKD 1135

Query: 1564 SSSEKESELKPLVGE-SRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVC--------- 1613
              S +     PL+ +  RS   +    +  +++    ++  E++  N+ +          
Sbjct: 1136 DLSPQ-----PLMTDFERSFREQGTYQSTYEQNT---EVAVEIHRLNLLLLRTVGMANRE 1187

Query: 1614 DQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEV---- 1669
                 IA   I G   ++S+     D+   L  + +M++   ++  + V  +G+ V    
Sbjct: 1188 KYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYEN 1246

Query: 1670 -------FRFQLTLYPDATEGEA----YADMSKVDGKLSFKVGCIQIVYVHKFF----MS 1714
                   F        DA   EA    + + SK +  L+ K+  +   +  KF     +S
Sbjct: 1247 IISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLS 1306

Query: 1715 LLNFLNNFQTAKEALST--ATVQAAERAASSMK------------------------DLA 1748
            +     NF+   ++ +T   TV A + A  S                          DLA
Sbjct: 1307 MDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLA 1366

Query: 1749 QK---SFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSLPPVID 1805
                 + +L+++IN+++PV+ IP+   SP  ++  LG I ++N F     E  S     D
Sbjct: 1367 SSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDDESRS-----D 1420

Query: 1806 KMNIELTQLKL 1816
            ++ +E+  +KL
Sbjct: 1421 RLQVEIKDIKL 1431



 Score = 39.7 bits (91), Expect = 0.055
 Identities = 86/375 (22%), Positives = 148/375 (39%), Gaps = 50/375 (13%)

Query: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTE 1376
            L  P  L+  V RNL     H VP + I G+L S++ SL+     L+  +L  NL E  E
Sbjct: 2201 LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIE 2260

Query: 1377 DLDKVKPRVQETGEIKEP-LEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNF---EIK 1432
            +   ++P      ++++P +   +S +V+     L         +D++N+ L     + K
Sbjct: 2261 EF--MRPY-----DLQDPRIHTVLSGEVYTCMCFL---------IDMVNVSLELKDPKRK 2304

Query: 1433 EVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFD--FTDSKGE 1490
            E   +L +   KK + L+E               + T    L   SM  FD  +   K  
Sbjct: 2305 EGAGSLARFDFKKCKLLYE------------SFSNQTKSINLVSHSMMAFDTRYAGQKTS 2352

Query: 1491 PLHIINSSNVTDEPLLKMLLTKADSD-GPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
            P  + N  +   +P      T+        F++  DS+     V   +L + L  + LL 
Sbjct: 2353 P-GMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSS--CFTVVLNNLRVFLIFDWLLL 2409

Query: 1550 FMDFLSSAAPF--------SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKI 1601
              DFL + +          S   +S  ES + P   +S  +  K  S  +S +   ++K+
Sbjct: 2410 VHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKS-GVVTKRSSLPVSNERHLEVKV 2468

Query: 1602 TAELNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTD--VFARLKDIIVMNVDLQSIHK 1659
                  F V + D  C   +  I      ++ KP+  D      L  I V +  L + H 
Sbjct: 2469 NVTGTEF-VVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHD 2527

Query: 1660 KAVSILGDEVFRFQL 1674
             A+SI+     + +L
Sbjct: 2528 TALSIVDPVQIQMEL 2542


>gi|54607139 vacuolar protein sorting 13D isoform 1 [Homo sapiens]
          Length = 4388

 Score =  218 bits (555), Expect = 9e-56
 Identities = 320/1522 (21%), Positives = 604/1522 (39%), Gaps = 311/1522 (20%)

Query: 2    VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQ 61
            +LE +VA +LN +LG YV NLN  QL + +  G V L+NL +K++AL EL++PF+VKAG 
Sbjct: 1    MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60

Query: 62   IDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEA 121
            I K+TL+IP+   + +  V ++  L+L+   GA  K     +EK     K  E  R +  
Sbjct: 61   IGKVTLQIPFYRPHVDPWVISISSLHLI---GAPEKIQDFNDEKE----KLLERERKKAL 113

Query: 122  LQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKDT 181
            LQ   EK                   K  R++K     +                    +
Sbjct: 114  LQALEEKW------------------KNDRQQKGESYWY--------------------S 135

Query: 182  FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
                + T++++N+++KI D+H+++ED VT+P  P +FG+ +  +S+  A        +NE
Sbjct: 136  VTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNA--------VNE 187

Query: 242  ADKIIYKLIRLD--SLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPI 299
              + + +  +LD    S YW+V+C++     + ++ + +   + +      ++ Y+ +P+
Sbjct: 188  PVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESR-----SHHYVLEPV 242

Query: 300  SASAKLYMNPYAESELKT---PKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAP 356
             ASA L  N  ++  L++   P++DC+I+++ I ++L++ QY  +++ L+ ++   R   
Sbjct: 243  FASALLKRN-CSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVK 301

Query: 357  YRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKL 416
            +R++KP + +  N R WW +A+++ L   IR   +  +W  +    +   SY   Y NKL
Sbjct: 302  FRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360

Query: 417  TQSKVSEEIQKEIQDLEKTLDVFNIILAR---------QQAQVEVIRSGQKLRKKSADTG 467
                +S + ++E+  +E+      + + R         Q+   E +R  Q     +    
Sbjct: 361  KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420

Query: 468  EKRGG----------WFSGLWGKKESKK------------KDEESLIPETI--------- 496
             + GG          WF G WG    ++            + +E  IPE I         
Sbjct: 421  PEPGGGSGMLQYLQSWFPG-WGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDP 479

Query: 497  ----DDLMTPEEKDKLFTAIGYSESTHNLTL-------PKQYVAHIMTL-----KLVSTS 540
                  + T  ++D +F  +        +TL       P+   +  M L     KL++ S
Sbjct: 480  TADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAES 539

Query: 541  VTIRENKNIPEILKIQIIGL--------GTQ----VSQRPGAQALKVEAKLEHWYITGLR 588
            +  R +     +L +++ GL        GT     V   P  +  +V          GL+
Sbjct: 540  LPRRNS----SLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSF------GLQ 589

Query: 589  QQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFF 648
                  S      D    + ++ +E NP  S  ++ L V ++P+ +IY+ + +  V +FF
Sbjct: 590  TTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFF 649

Query: 649  QSNK------GLDLE---QITSATLMKLEEIKERTATGLTH---------IIETRKVLDL 690
               K      G   E   ++  A   +  ++K +T   +            IE  K   +
Sbjct: 650  YKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTV 709

Query: 691  RINLKPSYLVVPQTGFHHEKSDLLILDFGTFQL-NSKDQGLQKTTNSSLEE--------- 740
            R+++    ++ P   F  +   L+++D G   L N++D   +K+ + S  E         
Sbjct: 710  RLDISAPQVIFPD-DFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEY 768

Query: 741  ----------------------------------------IMDKAYDKFDVEIKNVQLLF 760
                                                    +  K Y+++ +   ++Q++ 
Sbjct: 769  KTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMV 828

Query: 761  ARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISD 819
             R ++ WK  +       H+++  ++H++L + ++   D +     +SG LP + + I++
Sbjct: 829  GRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINE 888

Query: 820  QKMKDVLYLMNSIPLPQKSSAQSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYF 879
             K   +  L N   L      ++ + Q+          +G L  S++  T      +++ 
Sbjct: 889  DK---ISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHT 945

Query: 880  DAEDGEPQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNV 939
                 E Q   +       +     N   I++L  F        F K+  + +  L   V
Sbjct: 946  REVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTN---AHFVKRPYDAEVSL--TV 1000

Query: 940  TQLGTEATMRT----FDLTVVSYLKKISLDY--------------------HEIEGSKRK 975
              L    TM+T    FDL + S+ K +S D                     H  +G+   
Sbjct: 1001 HGLLLVDTMQTYGADFDLLMASH-KNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLN 1059

Query: 976  PLHLISSS-----DKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQ 1030
                 S S      K    L+K+EY       PS       T Q + +  ++L+++L  +
Sbjct: 1060 DRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTLQVISLQVNNLDIILNPE 1117

Query: 1031 ALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKL 1090
             +V  I +L    P +   +S    +       ++  T       + +  +   RL   L
Sbjct: 1118 TIVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLL 1177

Query: 1091 NAFCVIVCNEK--NNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPKTVHKKAVS 1148
                 +   EK    IA   I G   ++S+ S    +   L  + + D+    V  + V 
Sbjct: 1178 LRTVGMANREKYGRKIATASIGGTKVNVSMGS-TFDMNGSLGCLQLMDLTQDNVKNQYVV 1236

Query: 1149 IMGNEVFRFNL--DL---------YPDA--TEGDLYT--DMSKVDGVLSLNVGCIQIVYL 1193
             +GN V   N+  D+           DA  TE   +T  + SK +  L+L +  +   + 
Sbjct: 1237 SIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHS 1296

Query: 1194 HKFLMSLL--------NFLNNFQTAKESLSAATAQAAERAATSVK--------------- 1230
             KFL  L         NF    ++A   ++   A      +  V                
Sbjct: 1297 AKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILE 1356

Query: 1231 -------DLAQR---SFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSD 1280
                   DLA     + ++ +NI++++PV+ IP+   S   +V  LG I + N F    D
Sbjct: 1357 ENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDD 1415

Query: 1281 EDYLNPPVIDRMDVQLTKLTLY 1302
            E        DR+ V++  + LY
Sbjct: 1416 ESR-----SDRLQVEIKDIKLY 1432



 Score =  139 bits (350), Expect = 5e-32
 Identities = 117/442 (26%), Positives = 206/442 (46%), Gaps = 46/442 (10%)

Query: 3184 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDV 3243
            L+GI + + Q +    L   +  +QVDNQL G   P + + V P  +     E  P + V
Sbjct: 3854 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3912

Query: 3244 SVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQD 3303
            + +   ++ +    +K+ M+  Q   ++I++  L  +++ F      E+E      +++ 
Sbjct: 3913 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFG-YDQAESE------VEKY 3965

Query: 3304 IDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHSVNL 3363
             + L+ +  E   T   I  +FE+  IS  ++ LS+        S+K   ++ A+ S   
Sbjct: 3966 DENLHEKTAEQGGTP--IRYYFENLKISIPQIKLSVFT------SNKLPLDLKALKS--- 4014

Query: 3364 LLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVL 3423
               ++G  L   +D +  L  +   + +  ++ +I  +++H+ E+ L Q   ++  +D L
Sbjct: 4015 ---TLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4071

Query: 3424 GNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITG 3483
            GNP GL+  +SEGV  L      G V G              L  +   G +   ++  G
Sbjct: 4072 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4114

Query: 3484 SVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGA 3543
            ++  GL   TMD  +Q + RE +       G+ L  G  G   G++GG+T +IT  VEG 
Sbjct: 4115 TLSDGLGK-TMDNRHQSE-REYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4172

Query: 3544 KKE-GAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAEST---EEVSSLRPPR- 3598
            K E G +GF  G+GKGLVG V +P  G +D AS T Q ++  A  +    +   +R PR 
Sbjct: 4173 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4232

Query: 3599 LIHEDGIIRPYDRQESEGSDLL 3620
                 G++  Y   ++EG + L
Sbjct: 4233 CTGPQGLLPRYSESQAEGQEQL 4254



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 65/289 (22%), Positives = 140/289 (48%), Gaps = 17/289 (5%)

Query: 990  LLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQS 1049
            L+ +     DK  P F +++ +  +++ V F+ L++L+  Q  V  +++      +D+ +
Sbjct: 1784 LVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHA 1843

Query: 1050 ISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKI 1109
            + +  E  +   K +     P A + S   D ++ +L  K+++  +++    + +A+  +
Sbjct: 1844 MRLPPEGILHNVKLE-----PHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANV 1898

Query: 1110 QGLDSSLSLQSRKQSLFARLENIIVTDVDPK-TVHKKAVSIMGNEVFRFNLDLY--PDAT 1166
              L + L +     +L   + ++ ++D+      +++  +  G E   F    Y  PD  
Sbjct: 1899 SKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPL 1958

Query: 1167 EGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAA 1226
                     + D  +SL +  +Q V+  +F   ++ F+ +F   ++ L     Q A    
Sbjct: 1959 L------RREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIEG 2009

Query: 1227 TSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQF 1275
             +V+D AQR  RV ++I+  APV++IP+SS S N +V +LG ++V N+F
Sbjct: 2010 QTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058



 Score = 82.8 bits (203), Expect = 6e-15
 Identities = 66/305 (21%), Positives = 147/305 (48%), Gaps = 20/305 (6%)

Query: 1490 EPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
            EP  ++  S   D+ L+ + +   D   PEF + ++   + + V F  LD+++ L+  + 
Sbjct: 1770 EPKILVGKSKF-DDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVV 1828

Query: 1550 FMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQ-KDVFDLKITAELNAF 1608
             +DF      F   S+++  +   P  G   ++ ++  +S  S  +D  + K+  ++++ 
Sbjct: 1829 ILDF------FGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSL 1882

Query: 1609 NVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQS-IHKKAVSILGD 1667
            ++ +      +A   +  + A + +      +   +  + + ++      +++  +  G+
Sbjct: 1883 SLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGE 1942

Query: 1668 EVFRFQLTLY--PDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1725
            E   FQ   Y  PD      +      D ++S ++  +Q V+  +F   ++ F+ +F   
Sbjct: 1943 EALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQL 1996

Query: 1726 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1785
            ++ L     Q A     +++D AQ+  R+L+DI   APV++IP+SS S N ++A+LG ++
Sbjct: 1997 QDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLK 2053

Query: 1786 VENKF 1790
            V+NKF
Sbjct: 2054 VKNKF 2058



 Score = 53.9 bits (128), Expect = 3e-06
 Identities = 96/441 (21%), Positives = 173/441 (39%), Gaps = 70/441 (15%)

Query: 2662 YIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTADVLHSRISGEIMEL-------- 2713
            + I+L P++ + NLLP  L + ++G      L  G  A  LH+  + + +EL        
Sbjct: 3176 HTIYLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEA-ALHTADTSQNIELGVSLENFP 3234

Query: 2714 ----VLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRIGSRMVLSVF 2769
                +L+    +N+    R+ D             +     + + +  R  GS  +  + 
Sbjct: 3235 LCKELLIPPGTQNYMVRMRLYDV------------NRRQLNLTIRIVCRAEGSLKIF-IS 3281

Query: 2770 SPYWLINKTTRVLQYRSEDIHVKHPADFRD--------IILFSFKKKNIFTKNKVQLKIS 2821
            +PYWLINKT   L +R ++        F +         +LF +  K     N   ++I 
Sbjct: 3282 APYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKE--QPNLCTMRIG 3339

Query: 2822 TS-------AWSSSFSLDTVGSYGCVKCPAN----NMEYLVGVSIK--MSSFNLSRIVTL 2868
                      W   FSLD       +K         + Y +G+ +K     +  + +V  
Sbjct: 3340 RGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIF 3399

Query: 2869 TPFCTIANKSSLELEVGEIA-SDGSMPTNKWNYIAS---SECLPFWPES-LSGKLCVR-- 2921
             P   + NKSS +L   +   + G    N   YI++   S  +  WP +     LCVR  
Sbjct: 3400 APRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLM 3459

Query: 2922 -VVGCEGSSKPFFYNRQDNGTLLSLEDLNGG---ILVDVNTAEHSTVITFSDYHEGSAPA 2977
             V  C  S    F   ++N   +++ D  G    + V++     +  I+FSD  +   P 
Sbjct: 3460 DVPNCIWSGG--FEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPF 3517

Query: 2978 LIMNHTPWDILTYKQSGSPEEMV---LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLL 3034
             I N +   ++ + Q G  E  +   + P  +  +AW +PT    +T T     G  ++ 
Sbjct: 3518 RIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT-VKGAGSSEI- 3574

Query: 3035 KDGCGQFPYDANIQIHWVSFL 3055
               C    +  N Q+++ +F+
Sbjct: 3575 --NCNMNDFQDNRQLYYENFI 3593



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 122/611 (19%), Positives = 236/611 (38%), Gaps = 138/611 (22%)

Query: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLL---FRILT--ENL 1371
            ++   N+   + R L  +   K P   + G+L  + + +N++ ++ L   F +LT  E  
Sbjct: 848  VVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMK 907

Query: 1372 CEGTEDLDKVKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEI 1431
               T+  +K+ P+ ++ G        S+   V +   ++    +  R V + + LL  E 
Sbjct: 908  TSDTQIKEKIFPQEEQRG--------SLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEF 959

Query: 1432 KEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYD----MTAKAYLKKISMQCF--DFT 1485
            K  V  +    E  GR +  L V         + YD    +T    L   +MQ +  DF 
Sbjct: 960  K--VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFD 1017

Query: 1486 -------------------DSKGE-PLHIINSSNVTD----------------------E 1503
                               DS+ + P+   N +++TD                      E
Sbjct: 1018 LLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQE 1077

Query: 1504 PLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPFSEP 1563
             L+K+      S+ P      DST Q + +   +LD++L+ E ++  + FL  + P  + 
Sbjct: 1078 SLIKLEYQFVSSECPSMNL--DSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKD 1135

Query: 1564 SSSEKESELKPLVGE-SRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVC--------- 1613
              S +     PL+ +  RS   +    +  +++    ++  E++  N+ +          
Sbjct: 1136 DLSPQ-----PLMTDFERSFREQGTYQSTYEQNT---EVAVEIHRLNLLLLRTVGMANRE 1187

Query: 1614 DQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEV---- 1669
                 IA   I G   ++S+     D+   L  + +M++   ++  + V  +G+ V    
Sbjct: 1188 KYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYEN 1246

Query: 1670 -------FRFQLTLYPDATEGEA----YADMSKVDGKLSFKVGCIQIVYVHKFF----MS 1714
                   F        DA   EA    + + SK +  L+ K+  +   +  KF     +S
Sbjct: 1247 IISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLS 1306

Query: 1715 LLNFLNNFQTAKEALST--ATVQAAERAASSMK------------------------DLA 1748
            +     NF+   ++ +T   TV A + A  S                          DLA
Sbjct: 1307 MDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLA 1366

Query: 1749 QK---SFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSLPPVID 1805
                 + +L+++IN+++PV+ IP+   SP  ++  LG I ++N F     E  S     D
Sbjct: 1367 SSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDDESRS-----D 1420

Query: 1806 KMNIELTQLKL 1816
            ++ +E+  +KL
Sbjct: 1421 RLQVEIKDIKL 1431



 Score = 39.7 bits (91), Expect = 0.055
 Identities = 86/375 (22%), Positives = 148/375 (39%), Gaps = 50/375 (13%)

Query: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTE 1376
            L  P  L+  V RNL     H VP + I G+L S++ SL+     L+  +L  NL E  E
Sbjct: 2201 LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIE 2260

Query: 1377 DLDKVKPRVQETGEIKEP-LEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNF---EIK 1432
            +   ++P      ++++P +   +S +V+     L         +D++N+ L     + K
Sbjct: 2261 EF--MRPY-----DLQDPRIHTVLSGEVYTCMCFL---------IDMVNVSLELKDPKRK 2304

Query: 1433 EVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFD--FTDSKGE 1490
            E   +L +   KK + L+E               + T    L   SM  FD  +   K  
Sbjct: 2305 EGAGSLARFDFKKCKLLYE------------SFSNQTKSINLVSHSMMAFDTRYAGQKTS 2352

Query: 1491 PLHIINSSNVTDEPLLKMLLTKADSD-GPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
            P  + N  +   +P      T+        F++  DS+     V   +L + L  + LL 
Sbjct: 2353 P-GMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSS--CFTVVLNNLRVFLIFDWLLL 2409

Query: 1550 FMDFLSSAAPF--------SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKI 1601
              DFL + +          S   +S  ES + P   +S  +  K  S  +S +   ++K+
Sbjct: 2410 VHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKS-GVVTKRSSLPVSNERHLEVKV 2468

Query: 1602 TAELNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTD--VFARLKDIIVMNVDLQSIHK 1659
                  F V + D  C   +  I      ++ KP+  D      L  I V +  L + H 
Sbjct: 2469 NVTGTEF-VVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHD 2527

Query: 1660 KAVSILGDEVFRFQL 1674
             A+SI+     + +L
Sbjct: 2528 TALSIVDPVQIQMEL 2542


>gi|35493713 vacuolar protein sorting 13B isoform 5 [Homo sapiens]
          Length = 4022

 Score =  107 bits (268), Expect = 2e-22
 Identities = 69/264 (26%), Positives = 121/264 (45%), Gaps = 13/264 (4%)

Query: 3352 KQEMFAVHSVNLLLKSIGATLT---DVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQ 3408
            K     +  VNLL+ SI A+L      D      + +E    F    QL+ ++  HY+  
Sbjct: 3584 KLRKLVIQPVNLLV-SIHASLKLYIASDHTPLSFSVFERGPIFTTARQLVHALAMHYAAG 3642

Query: 3409 FLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFG 3468
             L +   +V  LD+LG+P  L+R +  GV   F  P++G  +GP  F  G+  G  S   
Sbjct: 3643 ALFRAGWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSFVK 3702

Query: 3469 HTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGV 3528
            H   G    ++ +  S+ + +  +++D+E+  ++ E   + P   G+ L +G       +
Sbjct: 3703 HISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISL 3762

Query: 3529 VGGVTGIITKPVEGAKKEG---------AAGFFKGIGKGLVGAVARPTGGIVDMASSTFQ 3579
            +G + GI+ +P++  +K           A G   G+GKG++G   +P GG  ++ S T  
Sbjct: 3763 LGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGY 3822

Query: 3580 GIQRAAESTEEVSSLRPPRLIHED 3603
            GI   A  ++       P  +H D
Sbjct: 3823 GILHGAGLSQLPKQRHQPSDLHAD 3846



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 66/253 (26%), Positives = 111/253 (43%), Gaps = 54/253 (21%)

Query: 2   VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENAL-SELDVPFKVKAG 60
           +LES V  +L  ++  Y++NL  S L+L +WGG+V L  L++K + L  EL +PF   +G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            I +L + +PW  L  E VV T+  +  +           +K +  +QD  +   S    
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECI-----------LKLKDGIQDDHE---SCGSN 106

Query: 121 ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
           +  ++  + T S              IKP R +           +      D P      
Sbjct: 107 STNRSTAESTKS-------------SIKPRRMQ-----------QAAPTDPDLP-----P 137

Query: 181 TFVEKLATQVIKNVQVKITDIHIKY-EDDVTDPKRPLSFGVTLGELSLLTANEHWTPCI- 238
            +V+ L  +V+ NV + I ++ +KY EDD+      LS  +T  E    T  E W     
Sbjct: 138 GYVQSLIRRVVNNVNIVINNLILKYVEDDIV-----LSVNITSAE--CYTVGELWDRAFM 190

Query: 239 -LNEADKIIYKLI 250
            ++  D ++ K+I
Sbjct: 191 DISATDLVLRKVI 203


>gi|35493701 vacuolar protein sorting 13B isoform 1 [Homo sapiens]
          Length = 3997

 Score =  107 bits (268), Expect = 2e-22
 Identities = 69/264 (26%), Positives = 121/264 (45%), Gaps = 13/264 (4%)

Query: 3352 KQEMFAVHSVNLLLKSIGATLT---DVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQ 3408
            K     +  VNLL+ SI A+L      D      + +E    F    QL+ ++  HY+  
Sbjct: 3559 KLRKLVIQPVNLLV-SIHASLKLYIASDHTPLSFSVFERGPIFTTARQLVHALAMHYAAG 3617

Query: 3409 FLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFG 3468
             L +   +V  LD+LG+P  L+R +  GV   F  P++G  +GP  F  G+  G  S   
Sbjct: 3618 ALFRAGWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSFVK 3677

Query: 3469 HTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGV 3528
            H   G    ++ +  S+ + +  +++D+E+  ++ E   + P   G+ L +G       +
Sbjct: 3678 HISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISL 3737

Query: 3529 VGGVTGIITKPVEGAKKEG---------AAGFFKGIGKGLVGAVARPTGGIVDMASSTFQ 3579
            +G + GI+ +P++  +K           A G   G+GKG++G   +P GG  ++ S T  
Sbjct: 3738 LGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGY 3797

Query: 3580 GIQRAAESTEEVSSLRPPRLIHED 3603
            GI   A  ++       P  +H D
Sbjct: 3798 GILHGAGLSQLPKQRHQPSDLHAD 3821



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 66/253 (26%), Positives = 111/253 (43%), Gaps = 54/253 (21%)

Query: 2   VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENAL-SELDVPFKVKAG 60
           +LES V  +L  ++  Y++NL  S L+L +WGG+V L  L++K + L  EL +PF   +G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            I +L + +PW  L  E VV T+  +  +           +K +  +QD  +   S    
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECI-----------LKLKDGIQDDHE---SCGSN 106

Query: 121 ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
           +  ++  + T S              IKP R +           +      D P      
Sbjct: 107 STNRSTAESTKS-------------SIKPRRMQ-----------QAAPTDPDLP-----P 137

Query: 181 TFVEKLATQVIKNVQVKITDIHIKY-EDDVTDPKRPLSFGVTLGELSLLTANEHWTPCI- 238
            +V+ L  +V+ NV + I ++ +KY EDD+      LS  +T  E    T  E W     
Sbjct: 138 GYVQSLIRRVVNNVNIVINNLILKYVEDDIV-----LSVNITSAE--CYTVGELWDRAFM 190

Query: 239 -LNEADKIIYKLI 250
            ++  D ++ K+I
Sbjct: 191 DISATDLVLRKVI 203


>gi|119874215 vacuolar protein sorting 13B isoform 4 [Homo sapiens]
          Length = 415

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 66/253 (26%), Positives = 111/253 (43%), Gaps = 54/253 (21%)

Query: 2   VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENAL-SELDVPFKVKAG 60
           +LES V  +L  ++  Y++NL  S L+L +WGG+V L  L++K + L  EL +PF   +G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            I +L + +PW  L  E VV T+  +  +           +K +  +QD  +   S    
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECI-----------LKLKDGIQDDHE---SCGSN 106

Query: 121 ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
           +  ++  + T S              IKP R +           +      D P      
Sbjct: 107 STNRSTAESTKS-------------SIKPRRMQ-----------QAAPTDPDLP-----P 137

Query: 181 TFVEKLATQVIKNVQVKITDIHIKY-EDDVTDPKRPLSFGVTLGELSLLTANEHWTPCI- 238
            +V+ L  +V+ NV + I ++ +KY EDD+      LS  +T  E    T  E W     
Sbjct: 138 GYVQSLIRRVVNNVNIVINNLILKYVEDDIV-----LSVNITSAE--CYTVGELWDRAFM 190

Query: 239 -LNEADKIIYKLI 250
            ++  D ++ K+I
Sbjct: 191 DISATDLVLRKVI 203


>gi|35493725 vacuolar protein sorting 13B isoform 3 [Homo sapiens]
          Length = 863

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 66/253 (26%), Positives = 111/253 (43%), Gaps = 54/253 (21%)

Query: 2   VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENAL-SELDVPFKVKAG 60
           +LES V  +L  ++  Y++NL  S L+L +WGG+V L  L++K + L  EL +PF   +G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120
            I +L + +PW  L  E VV T+  +  +           +K +  +QD  +   S    
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECI-----------LKLKDGIQDDHE---SCGSN 106

Query: 121 ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180
           +  ++  + T S              IKP R +           +      D P      
Sbjct: 107 STNRSTAESTKS-------------SIKPRRMQ-----------QAAPTDPDLP-----P 137

Query: 181 TFVEKLATQVIKNVQVKITDIHIKY-EDDVTDPKRPLSFGVTLGELSLLTANEHWTPCI- 238
            +V+ L  +V+ NV + I ++ +KY EDD+      LS  +T  E    T  E W     
Sbjct: 138 GYVQSLIRRVVNNVNIVINNLILKYVEDDIV-----LSVNITSAE--CYTVGELWDRAFM 190

Query: 239 -LNEADKIIYKLI 250
            ++  D ++ K+I
Sbjct: 191 DISATDLVLRKVI 203


>gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]
          Length = 2078

 Score = 44.3 bits (103), Expect = 0.002
 Identities = 26/88 (29%), Positives = 47/88 (53%), Gaps = 5/88 (5%)

Query: 10  LLNRFLGDYV-ENLNKSQLKLGIWGGNVALDNLQIKENALSEL----DVPFKVKAGQIDK 64
           LL R+LG ++ E L+  QL L ++ G  +L  + + +  L+E+    D P +V  G I  
Sbjct: 17  LLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESADAPLEVTEGFIQS 76

Query: 65  LTLKIPWKNLYGEAVVATLEGLYLLVVP 92
           ++L +PW +L  +     + GL ++  P
Sbjct: 77  ISLSVPWGSLLQDNCALEVRGLEMVFRP 104


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 41.2 bits (95), Expect = 0.019
 Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 19/141 (13%)

Query: 385 HIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSKV------SEEIQKEIQDLEKTLDV 438
           +I + T+     +++ +R  +   ++  KN   Q K+        EIQ  ++DL++ L+ 
Sbjct: 191 YIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLER 250

Query: 439 FNIILARQQAQVEVIRSGQKLRKKSADTG---EKRGGW-------FSGLWGKKESKKKDE 488
             ++L +QQ QVE  R G++L+  SA      E+   W          +W ++E  ++ E
Sbjct: 251 AQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQE 310

Query: 489 ESLIPETIDDLMTPEEKDKLF 509
           E +  +   +L   E+++K++
Sbjct: 311 EKMCEQ---ELKIREQEEKMW 328


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 40.8 bits (94), Expect = 0.025
 Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 19/141 (13%)

Query: 385 HIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSKV------SEEIQKEIQDLEKTLDV 438
           +I + T+     +++ +R  +   ++  KN   Q K+        EIQ  ++DL++ L+ 
Sbjct: 191 YIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLER 250

Query: 439 FNIILARQQAQVEVIRSGQKLRKKSADTG---EKRGGW-------FSGLWGKKESKKKDE 488
             ++L +QQ QVE  R G++L+  SA      E+   W          +W ++E  ++ E
Sbjct: 251 AQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQE 310

Query: 489 ESLIPETIDDLMTPEEKDKLF 509
           E +  +   +L   E+++K++
Sbjct: 311 EKMCEQ---ELKIREQEEKMW 328


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 38.1 bits (87), Expect = 0.16
 Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 406 KSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSA- 464
           K+ K+  K +L +S+ SE IQ  +++L++ L+   ++L +QQ Q E    G++L+  SA 
Sbjct: 210 KNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268

Query: 465 -DTGEKRGGWFSGLWGKKESKKKDEESLIPETIDDLMTPEEK 505
                +    ++ L  ++E K   +E  I E  + +   EEK
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEK 310


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 37.7 bits (86), Expect = 0.21
 Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 406 KSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSA- 464
           K+ K+  K +L +S+ SE IQ  +++L++ L+   ++L +QQ Q E    G++L+  SA 
Sbjct: 222 KNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280

Query: 465 -DTGEKRGGWFSGLWGKKESKKKDEESLIPETIDDLMTPEEK 505
                +    ++ L  ++E K   +E  I E  + +   EEK
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK 322


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 37.7 bits (86), Expect = 0.21
 Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 406 KSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSA- 464
           K+ K+  K +L +S+ SE IQ  +++L++ L+   ++L +QQ Q E    G++L+  SA 
Sbjct: 222 KNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280

Query: 465 -DTGEKRGGWFSGLWGKKESKKKDEESLIPETIDDLMTPEEK 505
                +    ++ L  ++E K   +E  I E  + +   EEK
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK 322


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 37.7 bits (86), Expect = 0.21
 Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 406 KSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSA- 464
           K+ K+  K +L +S+ SE IQ  +++L++ L+   ++L +QQ Q E    G++L+  SA 
Sbjct: 283 KNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 341

Query: 465 -DTGEKRGGWFSGLWGKKESKKKDEESLIPETIDDLMTPEEK 505
                +    ++ L  ++E K   +E  I E  + +   EEK
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK 383


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 37.7 bits (86), Expect = 0.21
 Identities = 43/207 (20%), Positives = 87/207 (42%), Gaps = 24/207 (11%)

Query: 1346 GHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK---------------VKPRVQETGE 1390
            G L  +N SLNQE +NL+ +  +E+     ++ +K               +  R +ETG 
Sbjct: 977  GTLKEINASLNQEKMNLIQK--SESFANYIDEREKSISELSDQYKQEKLILLQRCEETGN 1034

Query: 1391 IKEPL--EISISQDVHDSKNTLT---TGVEEIRSVDIINMLLNF--EIKEVVVTLMKKSE 1443
              E L  +   +Q+ +     L    T + E R  ++  +   F  E +E +  L    E
Sbjct: 1035 AYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEE 1094

Query: 1444 KKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNVTDE 1503
            +    + EL  +Q  + +++      +K+    +  +     + + +    +N     +E
Sbjct: 1095 RNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENE 1154

Query: 1504 PLLKMLLTKADSDGPEFKTIHDSTKQR 1530
             L+K++ TK +    E + I +S K+R
Sbjct: 1155 QLMKVMKTKHECQNLESEPIRNSVKER 1181


>gi|13699824 kinesin family member 11 [Homo sapiens]
          Length = 1056

 Score = 37.4 bits (85), Expect = 0.27
 Identities = 73/355 (20%), Positives = 144/355 (40%), Gaps = 58/355 (16%)

Query: 413 KNKLTQSKVSEEIQKEIQDLEKT---LDVFNIILARQQAQVEVIRSGQK----LRKKSAD 465
           KN+L Q K   ++Q + Q+LE T   L    + L +++     + S ++       K  +
Sbjct: 444 KNELDQCK--SDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLN 501

Query: 466 TGEKRGGWFSGLWGKKESKKK------DEESLIPETIDDLMTPEEKDKLFTAIGYSESTH 519
           T E+     SGL  K + KK       + + +  + ++ L    E+       G S+   
Sbjct: 502 TVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEE---LIKDGSSKQKA 558

Query: 520 NLTLPKQYVAHIMTLKLVS----TSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKV 575
            L + K    ++++  + +    T+V +    +IPE +   +  +   + +    Q+L  
Sbjct: 559 MLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKE---QSLAA 615

Query: 576 EAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVI 635
           E+K     +  + + D++ SL   +  T  S+LKI                  SQ   + 
Sbjct: 616 ESKTVLQELINVLKTDLLSSLEMILSPTVVSILKI-----------------NSQLKHIF 658

Query: 636 YDAKTVNAVVEFFQSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLK 695
             + TV   +E    ++  +L+   S     L E++E T   +  ++E++K      NL 
Sbjct: 659 KTSLTVADKIE----DQKKELDGFLSILCNNLHELQENT---ICSLVESQKQCG---NLT 708

Query: 696 PSYLVVPQTGFHHEKSDLLILDFGTFQ---LNSKDQGLQKTTNSSLEEIMDKAYD 747
                + QT   H +    +++  T +   L  K + +QK  +S  E I  K+ D
Sbjct: 709 EDLKTIKQT---HSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKD 760


>gi|239746976 PREDICTED: similar to paraneoplastic antigen MA1 [Homo
            sapiens]
          Length = 601

 Score = 36.6 bits (83), Expect = 0.47
 Identities = 36/114 (31%), Positives = 44/114 (38%), Gaps = 30/114 (26%)

Query: 3447 GAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREEL 3506
            G  QGP+   EG   G RSL G   G     V+ + G+VG+                   
Sbjct: 67   GPAQGPQREEEGAP-GCRSLVGRGWGVGWAAVAEVQGTVGE------------------- 106

Query: 3507 SRQPRDFGDSLARGGKGFLRGVVGGVTG---IITKPVEGAKKEGAAGFFKGIGK 3557
             R    FG     GG+G L   VGG  G   +  K   G  KEG   +F G GK
Sbjct: 107  -RGALAFG-----GGRGLLAAGVGGAEGGCQVTRKIKRGRSKEGGGSWF-GAGK 153


>gi|93204861 protein phosphatase 1, regulatory (inhibitor) subunit 9A
            [Homo sapiens]
          Length = 1098

 Score = 36.6 bits (83), Expect = 0.47
 Identities = 92/479 (19%), Positives = 199/479 (41%), Gaps = 54/479 (11%)

Query: 16   GDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLY 75
            G+Y  +  + ++   + G ++A++  ++ EN   ++  P ++   ++     ++  K+  
Sbjct: 632  GEYATDEEEDEVGPVLPGSDMAIEVFELPEN--EDMFSPSELDTSKLSHKFKELQIKHAV 689

Query: 76   GEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEALQKAAEKGTHS-GE 134
             EA +  L+   L       ++++  K +      + KE     E+    A+   H+  E
Sbjct: 690  TEAEIQKLK-TKLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIEAQTLCHTVNE 748

Query: 135  FIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKDTFVEKLATQVIKNV 194
             +   ++      K   K KK  K F++  K LD  K +  E KK   +EK     ++ +
Sbjct: 749  HLKETQSQYQALEKKYNKAKKLIKDFQQ--KELDFIKRQEAERKKIEDLEKAHLVEVQGL 806

Query: 195  QVKITDIHIKY-------EDDVTDPKRPLSFGVTLGELSLLTANEH----WTPC---ILN 240
            QV+I D+  +           V +         +LGE+S     E+     T C   +  
Sbjct: 807  QVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTMENLDGKQTSCQDGLSQ 866

Query: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQR---SREQILDQLKNEILTSGNIPPNYQY--I 295
            + ++ + +  RLDS +       S+  +R   SR ++ D + +          N+ +   
Sbjct: 867  DLNEAVPETERLDSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDD 926

Query: 296  FQPISASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNA 355
            F P S S+       AE   KTP L      Q++A  L+  + L MID     D ++ + 
Sbjct: 927  FSPSSTSSADLSGLGAEP--KTPGLS-----QSLA--LSSDESLDMID-----DEILDDG 972

Query: 356  PYRKYKPYLPLHTNGRRWWKYAIDSV----LEVHIRRYTQMWSWSNIKKHRQLLKSYKIA 411
               K+          R   ++++  V    + +++ +Y   +S  NI   + L       
Sbjct: 973  QSPKHS-----QCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKL 1027

Query: 412  YKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKR 470
                +T S+    ++K++++++ +L+        ++AQ ++ +  +KLR+K  +  +++
Sbjct: 1028 KALGMTASQDRAVVKKKLKEMKMSLE------KARKAQEKMEKQREKLRRKEQEQMQRK 1080


>gi|169217313 PREDICTED: similar to paraneoplastic antigen MA1 [Homo
            sapiens]
          Length = 601

 Score = 36.2 bits (82), Expect = 0.61
 Identities = 36/114 (31%), Positives = 44/114 (38%), Gaps = 30/114 (26%)

Query: 3447 GAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMDKEYQQKRREEL 3506
            G  QGP+   EG   G RSL G   G     V+ + G+VG+                   
Sbjct: 67   GPAQGPQREEEGAP-GCRSLVGRGWGVGWAAVAEVQGTVGE------------------- 106

Query: 3507 SRQPRDFGDSLARGGKGFLRGVVGGVTG---IITKPVEGAKKEGAAGFFKGIGK 3557
             R    FG     GG+G L   VGG  G   +  K   G  KEG   +F G GK
Sbjct: 107  -RGACAFG-----GGRGLLAAGVGGAEGGCQVTRKIKRGRSKEGGGSWF-GAGK 153


>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
          Length = 849

 Score = 36.2 bits (82), Expect = 0.61
 Identities = 38/156 (24%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 1093 FCVIVCNEK-----NNIAEIKIQGLDSSLSLQSRKQSL------FARLENIIVTDVDPKT 1141
            F V +C EK     N + +++     S +S+++ +++L        +LE  + T   P+ 
Sbjct: 622  FLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPED 681

Query: 1142 VHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKV-DGVLSLNVGCIQIVYLHKFLMSL 1200
            +H K V+ M   V           T   L+ +M K+   ++      ++ V +  FL  L
Sbjct: 682  LHDKFVTKMSRFVISAKEQY---ETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDL 738

Query: 1201 LNFLNNF-QTAKESLSAATAQAAERAATSVKDLAQR 1235
             NF   F Q  KE++    A+  E+     K+LA+R
Sbjct: 739  NNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAER 774


>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
          Length = 1193

 Score = 36.2 bits (82), Expect = 0.61
 Identities = 38/156 (24%), Positives = 69/156 (44%), Gaps = 16/156 (10%)

Query: 1093 FCVIVCNEK-----NNIAEIKIQGLDSSLSLQSRKQSL------FARLENIIVTDVDPKT 1141
            F V +C EK     N + +++     S +S+++ +++L        +LE  + T   P+ 
Sbjct: 885  FLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPED 944

Query: 1142 VHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKV-DGVLSLNVGCIQIVYLHKFLMSL 1200
            +H K V+ M   V           T   L+ +M K+   ++      ++ V +  FL  L
Sbjct: 945  LHDKFVTKMSRFVISAKEQY---ETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDL 1001

Query: 1201 LNFLNNF-QTAKESLSAATAQAAERAATSVKDLAQR 1235
             NF   F Q  KE++    A+  E+     K+LA+R
Sbjct: 1002 NNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAER 1037


>gi|51988900 XPG-complementing protein [Homo sapiens]
          Length = 1186

 Score = 35.8 bits (81), Expect = 0.79
 Identities = 54/230 (23%), Positives = 94/230 (40%), Gaps = 31/230 (13%)

Query: 730 LQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHILQPMDIHVE 789
           LQ+T  SS+  +  +A D     ++NV    A+  E + +   +  +T    Q +   + 
Sbjct: 583 LQET--SSIVSVPSEAVDN----VENVVSFNAKEHENFLETIQEQQTTESAGQDL---IS 633

Query: 790 LAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSS 849
           + KA+   +I     +  G    +   ISD++++                A+ PE   +S
Sbjct: 634 IPKAVEPMEIDSEESESDGSFIEVQSVISDEELQ----------------AEFPE---TS 674

Query: 850 IPIISGGTKGLLGTSLLLDTVESES---DDEYFDAEDGEPQTCKSMKGSELKKAAEVPNE 906
            P    G + L+GT       ESES   D+   D  DGEPQ  +      L +  ++  E
Sbjct: 675 KPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKDAEDSLHEWQDINLE 734

Query: 907 ELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVV 956
           EL  L      ++  L+  KQQ+E     V     L ++  +R F +  +
Sbjct: 735 ELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFGIPYI 784


>gi|55749659 UHRF1 (ICBP90) binding protein 1-like isoform b [Homo
          sapiens]
          Length = 522

 Score = 34.3 bits (77), Expect = 2.3
 Identities = 19/85 (22%), Positives = 42/85 (49%), Gaps = 3/85 (3%)

Query: 3  LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSE-LDVPFKVKAGQ 61
          +  ++   + + L  + +NL+  ++ L    G   L NL++ E  L   LD+P  +   +
Sbjct: 1  MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINK 60

Query: 62 I--DKLTLKIPWKNLYGEAVVATLE 84
          +  +K +++IPW  L    +  +L+
Sbjct: 61 VFCNKASIRIPWTKLKTHPICLSLD 85


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 124,049,070
Number of Sequences: 37866
Number of extensions: 5346061
Number of successful extensions: 15557
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 15109
Number of HSP's gapped (non-prelim): 243
length of query: 3628
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3506
effective length of database: 13,627,866
effective search space: 47779298196
effective search space used: 47779298196
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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