Search of human proteins with 6382062

Search of human proteins with 6382062

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
         (1182 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]              2390   0.0  
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]            2284   0.0  
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]            2239   0.0  
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]            1296   0.0  
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...  1081   0.0  
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...  1080   0.0  
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]            1077   0.0  
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      371   e-102
gi|4503787 fyn-related kinase [Homo sapiens]                          370   e-102
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       369   e-101
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              368   e-101
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   364   e-100
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   364   e-100
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   364   e-100
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   359   7e-99
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   359   7e-99
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   358   1e-98
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   358   1e-98
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     355   2e-97
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   348   2e-95
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   347   4e-95
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 344   2e-94
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               332   1e-90
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   331   3e-90
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       322   1e-87
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     316   7e-86
gi|4758078 c-src tyrosine kinase [Homo sapiens]                       316   7e-86
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   305   2e-82
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                305   2e-82
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      295   2e-79

>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 2390 bits (6193), Expect = 0.0
 Identities = 1182/1182 (100%), Positives = 1182/1182 (100%)

Query: 1    MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE 60
            MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
Sbjct: 1    MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE 60

Query: 61   DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 120
            DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
Sbjct: 61   DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 120

Query: 121  SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 180
            SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
Sbjct: 121  SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 180

Query: 181  SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 240
            SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
Sbjct: 181  SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 240

Query: 241  LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 300
            LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
Sbjct: 241  LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 300

Query: 301  EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360
            EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
Sbjct: 301  EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360

Query: 361  TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 420
            TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
Sbjct: 361  TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 420

Query: 421  HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 480
            HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
Sbjct: 421  HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 480

Query: 481  YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540
            YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
Sbjct: 481  YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540

Query: 541  TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE 600
            TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
Sbjct: 541  TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE 600

Query: 601  NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR 660
            NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
Sbjct: 601  NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR 660

Query: 661  NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG 720
            NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
Sbjct: 661  NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG 720

Query: 721  SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR 780
            SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
Sbjct: 721  SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR 780

Query: 781  SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES 840
            SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
Sbjct: 781  SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES 840

Query: 841  AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG 900
            AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
Sbjct: 841  AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG 900

Query: 901  MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL 960
            MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
Sbjct: 901  MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL 960

Query: 961  LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE 1020
            LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
Sbjct: 961  LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE 1020

Query: 1021 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS 1080
            GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
Sbjct: 1021 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS 1080

Query: 1081 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV 1140
            ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
Sbjct: 1081 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV 1140

Query: 1141 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
            SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1141 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 2284 bits (5919), Expect = 0.0
 Identities = 1130/1130 (100%), Positives = 1130/1130 (100%)

Query: 53   DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 112
            DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF
Sbjct: 38   DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 97

Query: 113  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172
            VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS
Sbjct: 98   VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157

Query: 173  WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232
            WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV
Sbjct: 158  WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217

Query: 233  TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 292
            TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH
Sbjct: 218  TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 277

Query: 293  KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352
            KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT
Sbjct: 278  KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337

Query: 353  LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412
            LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA
Sbjct: 338  LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397

Query: 413  RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472
            RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG
Sbjct: 398  RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457

Query: 473  VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
            VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF
Sbjct: 458  VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517

Query: 533  AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 592
            AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI
Sbjct: 518  AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 577

Query: 593  EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 652
            EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF
Sbjct: 578  EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 637

Query: 653  FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL 712
            FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL
Sbjct: 638  FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL 697

Query: 713  VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD 772
            VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD
Sbjct: 698  VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD 757

Query: 773  DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM 832
            DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM
Sbjct: 758  DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM 817

Query: 833  LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE 892
            LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE
Sbjct: 818  LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE 877

Query: 893  KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD 952
            KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD
Sbjct: 878  KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD 937

Query: 953  SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG 1012
            SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG
Sbjct: 938  SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG 997

Query: 1013 QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT 1072
            QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT
Sbjct: 998  QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT 1057

Query: 1073 KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN 1132
            KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN
Sbjct: 1058 KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN 1117

Query: 1133 KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
            KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1118 KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1167


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 2239 bits (5801), Expect = 0.0
 Identities = 1109/1109 (100%), Positives = 1109/1109 (100%)

Query: 74   EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 133
            EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 38   EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 97

Query: 134  LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 193
            LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 98   LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 157

Query: 194  SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 253
            SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 158  SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 217

Query: 254  GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 313
            GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 218  GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 277

Query: 314  VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 373
            VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 278  VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 337

Query: 374  RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 433
            RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 338  RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 397

Query: 434  MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 493
            MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 398  MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 457

Query: 494  VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA 553
            VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA
Sbjct: 458  VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA 517

Query: 554  EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG 613
            EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG
Sbjct: 518  EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG 577

Query: 614  AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR 673
            AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR
Sbjct: 578  AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR 637

Query: 674  EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG 733
            EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG
Sbjct: 638  EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG 697

Query: 734  GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE 793
            GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE
Sbjct: 698  GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE 757

Query: 794  QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL 853
            QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL
Sbjct: 758  QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL 817

Query: 854  PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW 913
            PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW
Sbjct: 818  PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW 877

Query: 914  PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 973
            PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD
Sbjct: 878  PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 937

Query: 974  RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS 1033
            RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS
Sbjct: 938  RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS 997

Query: 1034 GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA 1093
            GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA
Sbjct: 998  GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA 1057

Query: 1094 DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS 1153
            DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS
Sbjct: 1058 DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS 1117

Query: 1154 SAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
            SAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1118 SAAAGVPGTNPVLNNLLSCVQEISDVVQR 1146


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 1296 bits (3355), Expect = 0.0
 Identities = 635/635 (100%), Positives = 635/635 (100%)

Query: 53  DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 112
           DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF
Sbjct: 38  DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 97

Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172
           VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS
Sbjct: 98  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157

Query: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232
           WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217

Query: 233 TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 292
           TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH
Sbjct: 218 TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 277

Query: 293 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352
           KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337

Query: 353 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412
           LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397

Query: 413 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472
           RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG
Sbjct: 398 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457

Query: 473 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
           VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF
Sbjct: 458 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517

Query: 533 AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 592
           AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI
Sbjct: 518 AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 577

Query: 593 EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 652
           EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF
Sbjct: 578 EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 637

Query: 653 FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG 687
           FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG
Sbjct: 638 FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG 672



 Score =  783 bits (2021), Expect = 0.0
 Identities = 393/394 (99%), Positives = 394/394 (100%)

Query: 789  SGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 848
            +GLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP
Sbjct: 671  TGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 730

Query: 849  KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 908
            KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG
Sbjct: 731  KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 790

Query: 909  EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 968
            EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS
Sbjct: 791  EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 850

Query: 969  SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 1028
            SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG
Sbjct: 851  SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 910

Query: 1029 AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 1088
            AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA
Sbjct: 911  AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 970

Query: 1089 LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1148
            LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ
Sbjct: 971  LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1030

Query: 1149 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
            ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1031 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1064


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
            [Homo sapiens]
          Length = 1149

 Score = 1081 bits (2796), Expect = 0.0
 Identities = 647/1239 (52%), Positives = 778/1239 (62%), Gaps = 147/1239 (11%)

Query: 1    MGQQVGRV-GEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCV 59
            MGQQ G+V G+      P    I+G+   + S R   P         N+F +H       
Sbjct: 1    MGQQPGKVLGDQRRPSLPALHFIKGAGK-KESSRHGGPH-------CNVFVEH------- 45

Query: 60   EDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDF 118
                          EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDF
Sbjct: 46   --------------EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDF 91

Query: 119  VASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPV 178
            VASGDNTLSITKGEKLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPV
Sbjct: 92   VASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPV 151

Query: 179  SRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRF 238
            SR+AAEYLLSS INGSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF
Sbjct: 152  SRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRF 211

Query: 239  STLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQ 298
            +TLAELVHHHSTVADGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQ
Sbjct: 212  NTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQ 271

Query: 299  YGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFY 358
            YGEVY GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFY
Sbjct: 272  YGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFY 331

Query: 359  IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG 418
            I+TE+M YGNLLDYLRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG
Sbjct: 332  IITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG 391

Query: 419  ENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEI 478
            ENH+VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEI
Sbjct: 392  ENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEI 451

Query: 479  ATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA 538
            ATYGMSPYPGIDLSQVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQA
Sbjct: 452  ATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA 511

Query: 539  FETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDA 598
            FETMF +SSIS+EV +ELG+     +V   L + P LP+KTRT ++  E+++  +  +  
Sbjct: 512  FETMFQESSISDEVEKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMP 570

Query: 599  TENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM- 657
                     P         + SP LPRK+R      L ED  E    +D+K   FS+ + 
Sbjct: 571  HSKGQGESDP----LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIK 624

Query: 658  -KKRNAPTPPKRSSSFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVP 714
             KK+ APTPPKRSSSFREM+ QP ++   E  G   S  +L      +FTP         
Sbjct: 625  KKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKS 678

Query: 715  PKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPT 769
            PK   G+        + GG               +GF +P L KK+  L +     G+  
Sbjct: 679  PKPSNGAGVPNGALRESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEE 723

Query: 770  ASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRA 829
                +SK F RS S S +  G  + +  ++TLPR+ Q +  Q + +              
Sbjct: 724  GGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------- 773

Query: 830  NDMLPKKSEESAAPSRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVG 880
                  KSE+ A P +     ++  + RG    P R     + A  E      +  PG  
Sbjct: 774  -----HKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSS 828

Query: 881  VAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLK 940
               +   P  ++       G+    E G+     +PA A PV PT+   K          
Sbjct: 829  PPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTS 885

Query: 941  HTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICS 1000
              PA+      +S+  + K  SE   +   DK +  R+KP  APPPPP            
Sbjct: 886  KGPAE------ESRVRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGG 931

Query: 1001 DPTEEPTALTAGQST---------------------SETQEGGKKAALGAVPISGKA--- 1036
             P++ P+   AG++                      S+  EG KK  L A P    A   
Sbjct: 932  KPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPS 991

Query: 1037 GRPVMPPPQVP--LPTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEA 1088
            G P+ P P VP  LP++S + A    + TA      T+V+LRKT+Q  E+I++  I+K  
Sbjct: 992  GTPISPAP-VPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGV 1050

Query: 1089 LLECADLLSSALT----EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLE 1144
            +L+  + L  A++    +   +S +++ G  L  +C  YVD I Q RNKFAFREA++KLE
Sbjct: 1051 VLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLE 1110

Query: 1145 LSLQELQVSSAAAGV-PGTNPVLNNLLSCVQEISDVVQR 1182
             +L+ELQ+  A AG  P      + LLS V+EISD+VQR
Sbjct: 1111 NNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1149


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
            [Homo sapiens]
          Length = 1130

 Score = 1080 bits (2794), Expect = 0.0
 Identities = 631/1165 (54%), Positives = 755/1165 (64%), Gaps = 117/1165 (10%)

Query: 74   EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 132
            EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 27   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86

Query: 133  KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 192
            KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 87   KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146

Query: 193  GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 252
            GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 147  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206

Query: 253  DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 312
            DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 207  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266

Query: 313  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 372
            TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 267  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326

Query: 373  LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 432
            LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 327  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386

Query: 433  LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 492
            LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 387  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446

Query: 493  QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 552
            QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+EV
Sbjct: 447  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 506

Query: 553  AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIR 612
             +ELG+     +V   L + P LP+KTRT ++  E+++  +  +           P    
Sbjct: 507  EKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDP---- 561

Query: 613  GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRNAPTPPKRSS 670
                 + SP LPRK+R      L ED  E    +D+K   FS+ +  KK+ APTPPKRSS
Sbjct: 562  LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS 619

Query: 671  SFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLC 728
            SFREM+ QP ++   E  G   S  +L      +FTP         PK   G+       
Sbjct: 620  SFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSNGAGVPNGAL 673

Query: 729  NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDTSKPFPRSNS 783
             + GG               +GF +P L KK+  L +     G+      +SK F RS S
Sbjct: 674  RESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCS 718

Query: 784  TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 843
             S +  G  + +  ++TLPR+ Q +  Q + +                    KSE+ A P
Sbjct: 719  ASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------------HKSEKPALP 763

Query: 844  SRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVAAAPKGKEKN 894
             +     ++  + RG    P R     + A  E      +  PG     +   P  ++  
Sbjct: 764  RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVT 823

Query: 895  GGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQ 954
                 G+    E G+     +PA A PV PT+   K            PA+      +S+
Sbjct: 824  VAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE------ESR 874

Query: 955  GNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQS 1014
              + K  SE   +   DK +  R+KP  APPPPP             P++ P+   AG++
Sbjct: 875  VRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQSPSQEAAGEA 926

Query: 1015 T---------------------SETQEGGKKAALGAVPISGKA---GRPVMPPPQVP--L 1048
                                  S+  EG KK  L A P    A   G P+ P P VP  L
Sbjct: 927  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAP-VPSTL 985

Query: 1049 PTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECADLLSSALT- 1101
            P++S + A    + TA      T+V+LRKT+Q  E+I++  I+K  +L+  + L  A++ 
Sbjct: 986  PSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISR 1045

Query: 1102 ---EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAG 1158
               +   +S +++ G  L  +C  YVD I Q RNKFAFREA++KLE +L+ELQ+  A AG
Sbjct: 1046 NSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAG 1105

Query: 1159 V-PGTNPVLNNLLSCVQEISDVVQR 1182
              P      + LLS V+EISD+VQR
Sbjct: 1106 SGPAATQDFSKLLSSVKEISDIVQR 1130


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 1077 bits (2784), Expect = 0.0
 Identities = 529/550 (96%), Positives = 529/550 (96%), Gaps = 21/550 (3%)

Query: 1   MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE 60
           MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH        
Sbjct: 1   MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH-------- 52

Query: 61  DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 120
                        EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
Sbjct: 53  -------------EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 99

Query: 121 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 180
           SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
Sbjct: 100 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 159

Query: 181 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 240
           SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
Sbjct: 160 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 219

Query: 241 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 300
           LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
Sbjct: 220 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 279

Query: 301 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360
           EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
Sbjct: 280 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 339

Query: 361 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 420
           TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
Sbjct: 340 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 399

Query: 421 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 480
           HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
Sbjct: 400 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 459

Query: 481 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540
           YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
Sbjct: 460 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 519

Query: 541 TMFHDSSISE 550
           TMFHDSSISE
Sbjct: 520 TMFHDSSISE 529


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  371 bits (952), Expect = e-102
 Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)

Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
           LFVALYD+ A  ++ LS  KGEK ++L  ++ G+W E RS      G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
           +   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
           I    +G  Y+T  ++F TL +LV H+S  ADGL   L   A  C  P   G++   D W
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261

Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
           E+ R  + ++ KLG G + EV++G W   +  VA+KTLK  TM  E FL+EA +MK++KH
Sbjct: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320

Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
             LVQL  V + E P YIVTEYM  G+LLD+L++     +    L+ MA Q+++ M Y+E
Sbjct: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379

Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
           + N+IHRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  
Sbjct: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439

Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
           F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+GYRM  P+ CP  ++ELM  C
Sbjct: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499

Query: 522 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
           WK  P +RP+F       E  F  +    +  E L
Sbjct: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  370 bits (949), Expect = e-102
 Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)

Query: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 163
           FVAL+D+ A     LS   G+KL+VL     G W         +  S+  QG++PSNY+ 
Sbjct: 47  FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106

Query: 164 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 221
              SL+   W+ G + RS AE   L S    GSFL+RESES  G+ S+S+     V HYR
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166

Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 280
           I    +G  ++T    FSTL E V H++  +DGL   L  P  K   P  + +S    D+
Sbjct: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226

Query: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 340
           WE++R  I +  +LG GQ+GEV+ G+W   +  VAVKTLK  +M+  +FL+EA +MK ++
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285

Query: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400
           HP L+QL  VCTLE P YI+TE M +G+L +YL+     ++     + MA Q++S M YL
Sbjct: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345

Query: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 457
           E +N+IHRDLAARN LVGE+++ KVADFGL+R+      D Y +    K P+KWTAPE++
Sbjct: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405

Query: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 517
             N FSIKSDVW+FG+LL+EI TYG  PY G+  +QV  +L + YR+ QP  CP + Y +
Sbjct: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465

Query: 518 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 550
           M  CW   P +RP+F       E  F  DSS S+
Sbjct: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  369 bits (946), Expect = e-101
 Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)

Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
           LFVALYD+ A  ++ LS  KGEK ++L  ++ G+W E RS      G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
           +   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 280
           I    +G  Y+T  ++F TL +LV H+S  A GL   L  P  K   P +  +S    D 
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263

Query: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 340
           WE+ R  + +  +LG GQ+GEV++G W   +  VA+KTLK  TM  E FL+EA +MK++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322

Query: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400
           H  LVQL  V + E P YIVTEYM  G+LLD+L++     +    L+ MA Q+++ M Y+
Sbjct: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381

Query: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 460
           E+ N+IHRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y 
Sbjct: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441

Query: 461 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520
            F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+GYRM  P+ CP  ++ELM  
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501

Query: 521 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
           CWK  P +RP+F       E  F  +    +  E L
Sbjct: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  368 bits (944), Expect = e-101
 Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)

Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
           +FVALYD+ A     LS  KGE+ +++  N  G+W E RS      G++PSNY+ P +S+
Sbjct: 95  IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153

Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
           +   WY G + R  AE LL +  N  G FLVRESE++ G  S+S+R         V HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213

Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
           I    +G  Y+T  ++F TL +LV H++  ADGL   L    P   KP   G++   D W
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270

Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
           E+ R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA +MK+++H
Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329

Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
             LV L  V + E P YIVTE+M  G+LLD+L+E + + +    L+ MA QI+  M Y+E
Sbjct: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388

Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
           + N+IHRDL A N LVGEN V K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  
Sbjct: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448

Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
           F+IKSDVW+FG+L  E+ T G  PYPG+   +V + +E+GYRM  P+GCP  ++ELM  C
Sbjct: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508

Query: 522 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
           WK  P +RP+F       E  F  +    +  E L
Sbjct: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  364 bits (934), Expect = e-100
 Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%)

Query: 30  PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89
           P    ++ AG   E  F  +   DH+      G +  K   +S  A H P   +   QA+
Sbjct: 11  PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61

Query: 90  NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149
           N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W E R
Sbjct: 62  NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118

Query: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205
           S +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G
Sbjct: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178

Query: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260
             S+S+R         V HY+I     G  Y+T   +F+++ ELV H+  V DGL   L 
Sbjct: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238

Query: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320
            P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W   S  VAVKTLK
Sbjct: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294

Query: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380
             TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G+LLD+L+    ++
Sbjct: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353

Query: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440
           +    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y 
Sbjct: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413

Query: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
              G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+
Sbjct: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473

Query: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543
           GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  364 bits (934), Expect = e-100
 Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%)

Query: 30  PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89
           P    ++ AG   E  F  +   DH+      G +  K   +S  A H P   +   QA+
Sbjct: 11  PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61

Query: 90  NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149
           N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W E R
Sbjct: 62  NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118

Query: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205
           S +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G
Sbjct: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178

Query: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260
             S+S+R         V HY+I     G  Y+T   +F+++ ELV H+  V DGL   L 
Sbjct: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238

Query: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320
            P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W   S  VAVKTLK
Sbjct: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294

Query: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380
             TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G+LLD+L+    ++
Sbjct: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353

Query: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440
           +    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y 
Sbjct: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413

Query: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
              G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+
Sbjct: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473

Query: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543
           GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  364 bits (934), Expect = e-100
 Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%)

Query: 30  PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89
           P    ++ AG   E  F  +   DH+      G +  K   +S  A H P   +   QA+
Sbjct: 11  PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61

Query: 90  NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149
           N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W E R
Sbjct: 62  NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118

Query: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205
           S +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G
Sbjct: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178

Query: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260
             S+S+R         V HY+I     G  Y+T   +F+++ ELV H+  V DGL   L 
Sbjct: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238

Query: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320
            P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W   S  VAVKTLK
Sbjct: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294

Query: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380
             TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G+LLD+L+    ++
Sbjct: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353

Query: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440
           +    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y 
Sbjct: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413

Query: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
              G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+
Sbjct: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473

Query: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543
           GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  359 bits (922), Expect = 7e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 170
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148

Query: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 223
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208

Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 283
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265

Query: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 343
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324

Query: 344 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383

Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443

Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503

Query: 524 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
             P +RP+F       E  F  +    +  E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  359 bits (922), Expect = 7e-99
 Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)

Query: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 170
           FVALYD+ +  +  LS  KGE+L+++   +   W       GQ G++PSNY+ P +S++ 
Sbjct: 89  FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148

Query: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 223
             WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +G  V HY+I 
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208

Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 283
               G  Y+T+ ++F++L +LV ++S  ADGL   L    P  +KP   G++   D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265

Query: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 343
            R  + ++ KLG G +GEV++G W   +  VA+KTLK  TM  E FL+EA VMK+++H  
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324

Query: 344 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
           LVQL  V + E P YIVTEYM  G+LLD+L+    + +    L+ MA QI+S M Y+E+ 
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383

Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
           N++HRDL A N LVGEN V KVADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443

Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
           IKSDVW+FG+LL E+ T G  PYPG+   +V D +E+GYRM  P  CP  +++LM  CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503

Query: 524 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
             P +RP+F       E  F  +    +  E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  358 bits (920), Expect = 1e-98
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 104 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 161
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115

Query: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 215
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175

Query: 216 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 272
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234

Query: 273 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 332
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288

Query: 333 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 392
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347

Query: 393 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 452
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407

Query: 453 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467

Query: 513 KVYELMRACWKWSPADRPSFAETHQAFETMF 543
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  358 bits (920), Expect = 1e-98
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 104 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 161
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115

Query: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 215
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175

Query: 216 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 272
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234

Query: 273 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 332
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288

Query: 333 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 392
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347

Query: 393 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 452
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407

Query: 453 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467

Query: 513 KVYELMRACWKWSPADRPSFAETHQAFETMF 543
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  355 bits (910), Expect = 2e-97
 Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)

Query: 96  SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 151
           S   N  G  E  S+  + VALYD+ A     LS  KG+++ VL   ++GEW + RS   
Sbjct: 65  SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122

Query: 152 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 209
             +G++PSNY+  V+SLE   W+   +SR  AE  L +  N  GSF++R+SE++ G  S+
Sbjct: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182

Query: 210 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 262
           S+R Y+ R    V HY+I T  +G  Y++  S FSTL ELV H+    DGL   L  P  
Sbjct: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242

Query: 263 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 322
           + K  KP         D WE+ R  + ++ KLG GQ+GEV++  + K++  VAVKT+K  
Sbjct: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295

Query: 323 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 382
           +M VE FL EA VMK ++H  LV+L  V T EP  YI+TE+M  G+LLD+L+     +  
Sbjct: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354

Query: 383 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 442
              L+  + QI+  M ++E++N+IHRDL A N LV  + V K+ADFGL+R++  + YTA 
Sbjct: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414

Query: 443 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 502
            GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+GY
Sbjct: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474

Query: 503 RMEQPEGCPPKVYELMRACWKWSPADRPSF 532
           RM +PE CP ++Y +M  CWK  P +RP+F
Sbjct: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  348 bits (893), Expect = 2e-95
 Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)

Query: 81  GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 140
           G D++ Q + E+     +       E   ++ VALY +     + LS  KGEK++VL   
Sbjct: 16  GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73

Query: 141 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 196
           ++GEW + +S     +G++PSNY+  +N+LE   W+   ++R  AE  L +  N  G+FL
Sbjct: 74  EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133

Query: 197 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 251
           +RESE+  G  S+S+R    V+     HY+I +  +G  Y++    F  +++++ H+   
Sbjct: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193

Query: 252 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 309
           ADGL   L     +PK  KP         D WE+ R  I +  +LG GQ+GEV++G +  
Sbjct: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247

Query: 310 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 369
            S  VAVKTLK  TM V+ FL+EA +MK ++H  LV+L  V T E P YI+TEYM  G+L
Sbjct: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306

Query: 370 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
           LD+L+     +V    L+  + QI+  M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366

Query: 430 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 489
           L+R++  + YTA  GAKFPIKWTAPE++ +  F+IKSDVW+FG+LL+EI TYG  PYPG 
Sbjct: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426

Query: 490 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
             + V   L +GYRM + E CP ++Y++M+ CWK    +RP+F
Sbjct: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  347 bits (890), Expect = 4e-95
 Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)

Query: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 163
           E   ++ VALY +     + LS  KGEK++VL   ++GEW + +S     +G++PSNY+ 
Sbjct: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119

Query: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 218
            +N+LE   W+   ++R  AE  L +  N  G+FL+RESE+  G  S+S+R    V+   
Sbjct: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179

Query: 219 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 274
             HY+I +  +G  Y++    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236

Query: 275 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 334
               D WE+ R  I +  +LG GQ+GEV++G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292

Query: 335 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 394
           +MK ++H  LV+L  V T E P YI+TEYM  G+LLD+L+     +V    L+  + QI+
Sbjct: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352

Query: 395 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 454
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412

Query: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L +GYRM + E CP ++
Sbjct: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472

Query: 515 YELMRACWKWSPADRPSF 532
           Y++M+ CWK    +RP+F
Sbjct: 473 YDIMKMCWKEKAEERPTF 490


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  344 bits (883), Expect = 2e-94
 Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)

Query: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 163
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W   RS     +G+VPSN++ 
Sbjct: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114

Query: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 217
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174

Query: 218 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 277
            HY+I    +G  Y++    F +L  LV H+S   DGL   L  P   C +P        
Sbjct: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230

Query: 278 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 337
            D+WE+ R  + +  KLG GQ+GEV++G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289

Query: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 397
            ++H  LV+L  V T EP  YIVTEYM  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348

Query: 398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 457
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407

Query: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 516
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+GYRM +P+ CPP++Y  
Sbjct: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467

Query: 517 LMRACWKWSPADRPSFAETHQAFETMF 543
           ++  CW+  P +RP+F       E  +
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  332 bits (851), Expect = 1e-90
 Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)

Query: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 163
           ++   + VA+YDF A+  + L + +G++  +L  N +  W   R K G +G++PSNY+T 
Sbjct: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236

Query: 164 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 215
              N+L+++ WY   ++RS AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295

Query: 216 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 271
             R YH +  TT+  K Y+  +  F ++ E++ +H   A GLVT L YP     K  PT 
Sbjct: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355

Query: 272 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 331
            G S  ++KWE+  +++T   +LG G +G V +G W+     VA+K ++E  M  E+F++
Sbjct: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412

Query: 332 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 391
           EA VM ++ HP LVQL GVCT + P YIVTE+M  G LL++LR+  +   +  VLL M  
Sbjct: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471

Query: 392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 451
            +   MEYLE+ +FIHRDLAARNCLV E  VVKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531

Query: 452 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 511
             PE   Y+ FS KSDVW+FGVL+WE+ T G  P+      +V  ++ +G+R+ QP+   
Sbjct: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591

Query: 512 PKVYELMRACWKWSPADRPSFAE 534
             VYE+M  CW+  P  RPSF +
Sbjct: 592 NYVYEVMLRCWQEKPEGRPSFED 614


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  331 bits (848), Expect = 3e-90
 Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)

Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 170
           VALYD++    N L + KG++  +L    N  W   R KNGQ G++PSNY+T   +S+E 
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278

Query: 171 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 223
           + WY   ++RS AE LL      G F+VR+S S  G+ ++S+        +G + HY + 
Sbjct: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337

Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 281
           +T   + Y+  +  FST+ EL+++H   + GL++ L YP  + NK  P+  G+   +  W
Sbjct: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395

Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
           E++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +EF++EA VM  + H
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454

Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
             LVQL GVCT + P +I+TEYM  G LL+YLRE  R       LL M   +  AMEYLE
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513

Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
            K F+HRDLAARNCLV +  VVKV+DFGLSR +  D YT+  G+KFP++W+ PE L Y+ 
Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573

Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
           FS KSD+WAFGVL+WEI + G  PY     S+  + + +G R+ +P     KVY +M +C
Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633

Query: 522 WKWSPADRPSF 532
           W     +RP+F
Sbjct: 634 WHEKADERPTF 644


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  322 bits (825), Expect = 1e-87
 Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)

Query: 114 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 170
           ALYDF+      L++ + E+  +L    N  W + R + G +G +PSNY+T   + +LE 
Sbjct: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147

Query: 171 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 223
           + WYH  ++R+ AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206

Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 281
               G+ YV     F ++ EL+ +H   A GL+T L YP        P   G S  ++KW
Sbjct: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264

Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
           E++ +++    ++G GQ+G V++G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323

Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
             LVQL GVC    P YIVTE+M  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382

Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +N 
Sbjct: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442

Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
           +S KSDVW+FGVL+WE+ T G  P+      QV + + +G+R+ +P   P  +YE+M +C
Sbjct: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502

Query: 522 WKWSPADRPSFAETHQA 538
           W   P  RP+FAE  +A
Sbjct: 503 WHEKPEGRPTFAELLRA 519


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  316 bits (810), Expect = 7e-86
 Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)

Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 171
           +A Y+F  + +  L   KG+ L ++   ++  W + ++K G +G +P+NY+     ++  
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 172 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
           +      W+HG ++R  AE LL     G FLVRES + PG  ++ +  +G+V HYRI   
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134

Query: 226 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 284
           A  K+ +  E  F  L +LV H+++ ADGL T L    PK  + TV      +   W + 
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191

Query: 285 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 344
             ++ +   +G G++G+V +G ++     VAVK +K D    + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248

Query: 345 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
           VQLLGV   E    YIVTEYM  G+L+DYLR   R  +    LL  +  +  AMEYLE  
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308

Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
           NF+HRDLAARN LV E++V KV+DFGL++  +    T     K P+KWTAPE+L    FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364

Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
            KSDVW+FG+LLWEI ++G  PYP I L  V   +EKGY+M+ P+GCPP VYE+M+ CW 
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424

Query: 524 WSPADRPSFAETHQAFE 540
              A RPSF +  +  E
Sbjct: 425 LDAAMRPSFLQLREQLE 441


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  316 bits (810), Expect = 7e-86
 Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)

Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 171
           +A Y+F  + +  L   KG+ L ++   ++  W + ++K G +G +P+NY+     ++  
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 172 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
           +      W+HG ++R  AE LL     G FLVRES + PG  ++ +  +G+V HYRI   
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134

Query: 226 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 284
           A  K+ +  E  F  L +LV H+++ ADGL T L    PK  + TV      +   W + 
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191

Query: 285 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 344
             ++ +   +G G++G+V +G ++     VAVK +K D    + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248

Query: 345 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
           VQLLGV   E    YIVTEYM  G+L+DYLR   R  +    LL  +  +  AMEYLE  
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308

Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
           NF+HRDLAARN LV E++V KV+DFGL++  +    T     K P+KWTAPE+L    FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364

Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
            KSDVW+FG+LLWEI ++G  PYP I L  V   +EKGY+M+ P+GCPP VYE+M+ CW 
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424

Query: 524 WSPADRPSFAETHQAFE 540
              A RPSF +  +  E
Sbjct: 425 LDAAMRPSFLQLREQLE 441


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  305 bits (781), Expect = 2e-82
 Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)

Query: 109 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 165
           P LF+ALYDF A     LS+ +G++L  L   + G +   R  +GQ   G VP  ++   
Sbjct: 53  PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110

Query: 166 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 221
           +  +L    WY   VSR+ A+ LL S  N  G+FL+R SESS G  S+S+R + +V HYR
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170

Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
           ++  ADG +Y+     F  L EL+ ++      +   L        +P +   +P  D W
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223

Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
           E   ++  +  KLG G +GEV+ G+W   SL VA+K +K   M++ +  KE   +K ++H
Sbjct: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282

Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
             L++L  VC+   P YIVTE M  GNL  +L       +    LL  A Q++  M YLE
Sbjct: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342

Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
           ++  +HRDLAARN LV +    KVADFGL+RL+  D Y+  + +K P+KWTAPE+  Y  
Sbjct: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402

Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
           FS KSDVW+FGVLL E+ TYG  PY G+   +    + +GYR+ +P  CP +VY LM  C
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462

Query: 522 WKWSPADRPSFA 533
           W+ SP +RPSFA
Sbjct: 463 WRSSPEERPSFA 474


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  305 bits (780), Expect = 2e-82
 Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)

Query: 81  GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 137
           GC   D    A  + +  + ++N     E +  + +ALYD+  +    L++ + E+  +L
Sbjct: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201

Query: 138 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 193
             ++   W  V+ +NG +G+VPS+Y+     N+LE + WY+  +SR  AE  LL +   G
Sbjct: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260

Query: 194 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 244
           +F+VR+S ++ G  ++S+  +  V        HY I  T D   + YV  +  F ++  L
Sbjct: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319

Query: 245 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 302
           +++H     GLVT L YP    +   P   G+   + KW ++ +++T   ++G GQ+G V
Sbjct: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377

Query: 303 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 362
           ++G W      VA+KT++E  M  E+F++EA VM ++ HP LVQL GVC  + P  +V E
Sbjct: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436

Query: 363 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 422
           +M +G L DYLR   R    A  LL M   +   M YLE+   IHRDLAARNCLVGEN V
Sbjct: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495

Query: 423 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 482
           +KV+DFG++R +  D YT+  G KFP+KW +PE  +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555

Query: 483 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 533
             PY     S+V + +  G+R+ +P      VY++M  CWK  P DRP+F+
Sbjct: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  295 bits (754), Expect = 2e-79
 Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)

Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
           LFVALYD+ A  ++ LS  KGEK ++L  ++ G+W E RS      G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
           +   WY G + R  AE  L S  N  G+FL+RESE++ G            Y   I    
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193

Query: 227 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 286
           D K                       D +    HY   K +    Y    I  + + E  
Sbjct: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224

Query: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 346
              ++H          Y G W   +  VA+KTLK  TM  E FL+EA +MK++KH  LVQ
Sbjct: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273

Query: 347 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 406
           L  V + E P YIVTEYM  G+LLD+L++     +    L+ MA Q+++ M Y+E+ N+I
Sbjct: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332

Query: 407 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 466
           HRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y  F+IKS
Sbjct: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392

Query: 467 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 526
           DVW+FG+LL E+ T G  PYPG++  +V + +E+GYRM  P+ CP  ++ELM  CWK  P
Sbjct: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452

Query: 527 ADRPSFAETHQAFETMFHDSSISEEVAEEL 556
            +RP+F       E  F  +    +  E L
Sbjct: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,436,648
Number of Sequences: 37866
Number of extensions: 2693123
Number of successful extensions: 16673
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 12227
Number of HSP's gapped (non-prelim): 3063
length of query: 1182
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1069
effective length of database: 13,968,660
effective search space: 14932497540
effective search space used: 14932497540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.