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Search of human proteins with 63054866
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63054866 leucine rich repeat containing 16A [Homo sapiens]
(1326 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63054866 leucine rich repeat containing 16A [Homo sapiens] 2598 0.0
gi|156938257 leucine rich repeat containing 16B [Homo sapiens] 853 0.0
gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain... 615 e-176
gi|118918429 NOD3 protein [Homo sapiens] 86 3e-16
gi|5174617 nucleotide-binding oligomerization domain containing ... 69 2e-11
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 63 2e-09
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 60 1e-08
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 55 6e-07
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 54 1e-06
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 54 1e-06
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 54 1e-06
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 53 2e-06
gi|23503285 leucine rich repeat containing 34 [Homo sapiens] 50 2e-05
gi|11545912 nucleotide-binding oligomerization domain containing... 49 3e-05
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 49 3e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 49 3e-05
gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens] 49 4e-05
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 47 9e-05
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 9e-05
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 47 1e-04
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 47 2e-04
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 45 5e-04
gi|76563940 synuclein alpha interacting protein [Homo sapiens] 45 6e-04
>gi|63054866 leucine rich repeat containing 16A [Homo sapiens]
Length = 1326
Score = 2598 bits (6734), Expect = 0.0
Identities = 1326/1326 (100%), Positives = 1326/1326 (100%)
Query: 1 MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARI 60
MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARI
Sbjct: 1 MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARI 60
Query: 61 PTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPG 120
PTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPG
Sbjct: 61 PTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPG 120
Query: 121 LSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQW 180
LSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQW
Sbjct: 121 LSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQW 180
Query: 181 DVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILR 240
DVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILR
Sbjct: 181 DVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILR 240
Query: 241 VVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQF 300
VVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQF
Sbjct: 241 VVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQF 300
Query: 301 AKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNF 360
AKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNF
Sbjct: 301 AKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNF 360
Query: 361 LAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFF 420
LAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFF
Sbjct: 361 LAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFF 420
Query: 421 SSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAE 480
SSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAE
Sbjct: 421 SSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAE 480
Query: 481 IHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQ 540
IHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQ
Sbjct: 481 IHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQ 540
Query: 541 DEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTK 600
DEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTK
Sbjct: 541 DEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTK 600
Query: 601 LRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIENY 660
LRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIENY
Sbjct: 601 LRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIENY 660
Query: 661 LLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSA 720
LLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSA
Sbjct: 661 LLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLKSA 720
Query: 721 ERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLE 780
ERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLE
Sbjct: 721 ERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKALLE 780
Query: 781 SMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLT 840
SMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLT
Sbjct: 781 SMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLT 840
Query: 841 VASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEE 900
VASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEE
Sbjct: 841 VASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRSIITVEE 900
Query: 901 LTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPS 960
LTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPS
Sbjct: 901 LTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPS 960
Query: 961 LRQEKRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMG 1020
LRQEKRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMG
Sbjct: 961 LRQEKRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMG 1020
Query: 1021 RVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKS 1080
RVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKS
Sbjct: 1021 RVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKS 1080
Query: 1081 ERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEI 1140
ERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEI
Sbjct: 1081 ERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEI 1140
Query: 1141 GKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAGSRS 1200
GKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAGSRS
Sbjct: 1141 GKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAGSRS 1200
Query: 1201 RSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVP 1260
RSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVP
Sbjct: 1201 RSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVP 1260
Query: 1261 SDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEEAE 1320
SDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEEAE
Sbjct: 1261 SDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEEAE 1320
Query: 1321 KEFIFV 1326
KEFIFV
Sbjct: 1321 KEFIFV 1326
>gi|156938257 leucine rich repeat containing 16B [Homo sapiens]
Length = 1372
Score = 853 bits (2203), Expect = 0.0
Identities = 543/1352 (40%), Positives = 782/1352 (57%), Gaps = 73/1352 (5%)
Query: 1 MTEESSDVPRELIESIKDVIGRKIKISVKKKVKLEVKGDKVENKVLVLTSCRAFLVTARI 60
M + S ++ REL +SI+ + + + + VKLE K K E++VL LTS R L ++
Sbjct: 1 MAKPSVELTRELQDSIRRCLSQGAVLQ-QHHVKLETKPKKFEDRVLALTSWRLHLFLLKV 59
Query: 61 PTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKIFPG 120
P K+E +F+ LEI Q++VETE+ +SM++ S E V +V H+ + L K+ PG
Sbjct: 60 PAKVESSFNVLEIRAFNTLSQNQILVETERGMVSMRLPSAESVDQVTRHVSSALSKVCPG 119
Query: 121 LSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCGGFSQMYACVCDWLGFSYREEVQW 180
P ++++ + + E ++ T CGGFS+ YA +CD+ G REEVQW
Sbjct: 120 --PGCLIRRGNADTPEGPRDTSPNSETSTSTTHSVCGGFSETYAALCDYNGLHCREEVQW 177
Query: 181 DVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILR 240
DVDTIY +D RE NL DFSHL+ RDL ++AAL YNQWFTKL KDL+L ++V EQ+L
Sbjct: 178 DVDTIYHAEDNREFNLLDFSHLESRDLALMVAALAYNQWFTKLYCKDLRLGSEVLEQVLH 237
Query: 241 VVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQF 300
+S+S LEELVL+NAGL+TDF QKLA N + LH + L+ NP+ED+G SLS Q
Sbjct: 238 TLSKSGSLEELVLDNAGLKTDFVQKLAGVFGENGSCVLHALTLSHNPIEDKGFLSLSQQL 297
Query: 301 AKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGN--VLRGDDLSHMY 358
P GL L L+KT++SP+G+ +L Q+ ANP AS+L +LDLS N +L D+ + +Y
Sbjct: 298 LCFPSGLTKLCLAKTAISPRGLQALGQTFGANPAFASSLRYLDLSKNPGLLATDEANALY 357
Query: 359 NFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQ 418
+FLAQPNA+VHLDLS T+C +D++ GALL GC +L LNL+R SHRKG+E PP+FKQ
Sbjct: 358 SFLAQPNALVHLDLSGTDCVIDLLLGALLHGCCSHLTYLNLARNSCSHRKGREAPPAFKQ 417
Query: 419 FFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCI 478
FFSS+ L H+NLS TKL E L+ALL GL+ N +L + LDLS+CELRS GAQ L+ +
Sbjct: 418 FFSSAYTLSHVNLSATKLPLEALRALLQGLSLNSHLSDLHLDLSSCELRSAGAQALQEQL 477
Query: 479 AEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQM 538
+ + SLD+SDNG +SDL TL+ L KN+S++HL LGKNFN +K+K L +L LVQ+
Sbjct: 478 GAVTCVGSLDLSDNGFDSDLLTLVPALGKNKSLKHLFLGKNFN-VKAKTLEEILHKLVQL 536
Query: 539 IQDEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQIN 598
IQ+E+ LQSLS+ADS+LK +I+INALGSNT L KVD+SGNGM D+GAKML+KALQIN
Sbjct: 537 IQEEDCSLQSLSVADSRLKLRTSILINALGSNTCLAKVDLSGNGMEDIGAKMLSKALQIN 596
Query: 599 TKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIE 658
+ LRT++WD+NN +A GF DIA A+E N+TLRFM P+ D SQA ++ PE+TED QKI+
Sbjct: 597 SSLRTILWDRNNTSALGFLDIARALESNHTLRFMSFPVSDISQAYRSAPERTEDVWQKIQ 656
Query: 659 NYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDLK 718
L+RN+ ++ QEQA+RLQQG+VTS+ +QM+ R+C +VQ+ + +LR C + +Q++L
Sbjct: 657 WCLVRNNHSQTCPQEQAFRLQQGLVTSSAEQMLQRLCGRVQEEVRALRLCPLEPVQDELL 716
Query: 719 SAERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKAL 778
A L++DAKNS+ L P+LY +G P+++ LES+A EV++ VD++L+ +
Sbjct: 717 YARDLIKDAKNSRALFPSLYELGHVL------ANDGPVRQRLESVASEVSKAVDKELQVI 770
Query: 779 LESMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVK 838
LESMV + LCP M+ A ++ E++++PR F++ LLEQ+G DI NK+ EVK
Sbjct: 771 LESMVSLTQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVK 830
Query: 839 LTVASFLSDRIVDEILDALSHCHHKLADHFSRRGKTLPQQESLEIELAEEKPVKRS-IIT 897
L+V ++L+ IVDEIL L H H LA H ++ +TL + + R
Sbjct: 831 LSVVTYLTSSIVDEILQELYHSHKSLARHLTQL-RTLSDPPGCPGQGQDLSSRGRGRNHD 889
Query: 898 VEELTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFE-MEFDLDKALEEVPIHIEDP 956
EE T+ E ++DT M K KR R +RPVS D++ L + I P
Sbjct: 890 HEETTDDELGTNIDT-MAIKKQKR----CRKIRPVSAFISGSPQDMESQLGNLGI----P 940
Query: 957 P--FPSL-RQEKRSSGF---ISELPSEEGKKLEHFTKLRPK--RNKKQQPTQAAVCAANI 1008
P F L + +SG +SELP+ G KL H T+ RP+ R P + ++ A
Sbjct: 941 PGWFSGLGGSQPTASGSWEGLSELPT-HGYKLRHQTQGRPRPPRTTPPGPGRPSMPAPG- 998
Query: 1009 VSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSS 1068
++NG+ R+DEG+++FF+++V + S T + L+E ++ R+
Sbjct: 999 ---TRQENGMATRLDEGLEDFFSRRVLEESSSYPRTLRTVRPGLSEAPLPPLQKKRRR-- 1053
Query: 1069 GFLNLIKSRS-KSER----PPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERI 1123
G + + RS K +R P T L+ P P SPP P + + E
Sbjct: 1054 GLFHFRRPRSFKGDRGPGSPTTGLLLPPPPPPPPTQESPPSPDPPSLGNNSSPCWSPE-- 1111
Query: 1124 EEIKTPDSFEESQG----EEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAK----Q 1175
EE F +G ++G + P G +V G L +AK
Sbjct: 1112 EESSLLPGFGGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRVHGVALPGLERAKGWSFD 1171
Query: 1176 ENRFGLGTPEKNTKAEPKAEAGSRSRSSSST-PTS--PKPLLQSPKPSLAARPVIPQKPR 1232
R G G + E +A + RSS P S P P QS KPS +A R
Sbjct: 1172 GKREGPGPDQ-----EGSTQAWQKRRSSDDAGPGSWKPPPPPQSTKPSFSAM-------R 1219
Query: 1233 TASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQ---PSPRTFSQEVSRRSWGQ 1289
A I + S+P + P ++E++G P+ P+ Q+ + W
Sbjct: 1220 RAEATWHIAEE-SAPNHSCQSPSPASQDGEEEKEGTLFPERTLPARNAKLQDPALAPWPP 1278
Query: 1290 QAQEYQEQKQRSSSKDGHQGSKSNDSGEEAEK 1321
+ +Q + +++ D+ K
Sbjct: 1279 KPVAVPRGRQPPQEPGVREEAEAGDAAPGVNK 1310
>gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain and
proline-rich containing [Homo sapiens]
Length = 1435
Score = 615 bits (1587), Expect = e-176
Identities = 433/1360 (31%), Positives = 697/1360 (51%), Gaps = 121/1360 (8%)
Query: 41 VENKVLVLTSCRAFLV-TARIPTKLELTFSYLEIHGVVCSKSA-QMIVETEKC-SISMKM 97
V+N VL L RA+L+ T +P +++ TFSYLE+ + ++ Q+ E E + ++
Sbjct: 39 VQNHVLALLRWRAYLLHTTCLPLRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEF 98
Query: 98 ASPEDVSEVLAHIGTCLRKIFPGLSPVRIMKKVSMEPSERLASLQALWDSQTVAEQGPCG 157
+ ++ H+ ++K+FP + ++ ++ + P+ LA L+ S++ PCG
Sbjct: 99 PGVAALEQLAQHVAAAIKKVFPRSTLGKLFRRPT--PASMLARLERSSPSESTDPCSPCG 156
Query: 158 GFSQMYACVCDWLGFSYREEVQWDVDTIYLTQDTRELNLQDFSHLDHRDLIPIIAALEYN 217
GF + Y +CD+ GF +REE+QWDVDTIY Q R +L DFSHL RDL +AAL YN
Sbjct: 157 GFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYN 216
Query: 218 QWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSG 277
WF LS D+KLS +V EQIL ++S+S+ LEELVLE LR DF ++LA ALA + +SG
Sbjct: 217 LWFRCLSCVDMKLSLEVSEQILHMMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSG 276
Query: 278 LHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTAS 337
L ++LAGN L+DRG+++LS + P L+ L+L++T L+P+G+ +L ++L+ N S
Sbjct: 277 LRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDS 336
Query: 338 TLVHLDLSGN---VLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCG---------- 384
TL HLDLSGN + +D +Y+FL++PN + L+L+ T+ +LD V G
Sbjct: 337 TLTHLDLSGNPGALGASEDSGGLYSFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGR 396
Query: 385 --------------------------ALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQ 418
A+ RGC L L+ SR VFS K + P + +
Sbjct: 397 ADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQL 456
Query: 419 FFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCI 478
F S + L H+ L+G KL P+ L+ALL GLA N +L+ + LDLS CELRS GAQV++ +
Sbjct: 457 FLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLV 516
Query: 479 AEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQM 538
+ ++SLD++DNG SD+ TL++ + ++RS++H+ALG+NFN + L VL +VQ+
Sbjct: 517 CDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQL 576
Query: 539 IQDEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQIN 598
+QD++ PLQSLS+A+S+LK ++++ AL +N +LT +DISGN MGD GAK+LAKAL++N
Sbjct: 577 MQDDDCPLQSLSVAESRLKLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVN 636
Query: 599 TKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIE 658
++LR+V+WD+N+ +A G D+A A+E+N++L+ MP+P+ D +QA ++ PE T A+ +I+
Sbjct: 637 SRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQ 696
Query: 659 NYLLRNHETRKYLQEQAYRLQQ-GIVTSTTQQMIDRICVKVQDHLNSLRNCGGDAIQEDL 717
LLRN+ + RLQ G+V+ ++Q ++ +C VQ+H+ L G + +
Sbjct: 697 ACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAV 756
Query: 718 KSAERLMRDAKNSKTLLPNLYHVGGASWAGASGLLSSPIQETLESMAGEVTRVVDEQLKA 777
+ AE +++A S ++LP LY AG+S + + LE + +V V + ++
Sbjct: 757 RQAEDAIQNANFSLSILPILYE------AGSSPSHHWQLGQKLEGLLRQVGEVCRQDIQD 810
Query: 778 LLESMVDAAENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEV 837
++ +D A +LCP +++ + R+ L +P +L EQ D ++ ++
Sbjct: 811 FTQATLDTARSLCPQMLQGSSWREQLEGVLAGSRGLP-----ELLPEQLLQDAFTRLRDM 865
Query: 838 KLTVASFLSDRIVDEILDALSHCHHKLADHFSRRG-----KTLPQQESLEIELAEEKPVK 892
+L++ L++ IV + L LS +L + +++ LP + E L E ++
Sbjct: 866 RLSITGTLAESIVAQALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELE 925
Query: 893 RSIITVEELTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIH 952
+ EE E + +D P+ + H L P + E + + L
Sbjct: 926 -GLFFPEEKEEEKEKDD-----SPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGED 979
Query: 953 IEDPPFPSLRQEKRSSG---FISELPSEE----GKKLEHFTKL--RPKRNKKQQPTQAAV 1003
E PS R + LP + G+ L H T+ RP+R +P
Sbjct: 980 AEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGP 1039
Query: 1004 CAANIVSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRD 1063
+ Q+G NGL RVDEGV+EFF+K++ + D + W+ E EGG R
Sbjct: 1040 QVPPALPQEG--NGLSARVDEGVEEFFSKRLIQQD-RLWA---PEEDPATEGGATPVPRT 1093
Query: 1064 SRKSSGFLNLIKSRSKSERPPTILMTEEPSSPK------GAVRSPPVDCPR--------K 1109
RK G L K + P T L T ++P+ G + PP R
Sbjct: 1094 LRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEG 1153
Query: 1110 DTKAAEHNG--------NSERIEEIKTPDSFEESQGEEIGK---VERSDSKSSPQAGRRY 1158
DT + + G +S+ I P E + G K +ER +++ +P +R
Sbjct: 1154 DTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRV 1213
Query: 1159 GVQVMGSGLL-----AEMKAKQENRFGL------GTPEKNTKAEPKAEAGSRSRSSSSTP 1207
V + G+ AE K KQ + G ++ P SR+ S S+ P
Sbjct: 1214 QVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADP 1273
Query: 1208 T-SPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERD 1266
+ P P Q P+ + SR D P P P + PS
Sbjct: 1274 SCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLG 1333
Query: 1267 GQSSPQPSPRTFSQEVSRR--SWGQQAQEYQEQKQRSSSK 1304
P PR ++ R S G++A E + ++ ++
Sbjct: 1334 LPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAE 1373
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 85.5 bits (210), Expect = 3e-16
Identities = 111/471 (23%), Positives = 203/471 (43%), Gaps = 51/471 (10%)
Query: 212 AALEYNQWFTKLSSKDLKLSTDVCEQILR-VVSRSNRLEELVLENAGLRTDFAQKLASAL 270
AAL Y + +++ LS + + +L+ ++ + +L L+ + + L S L
Sbjct: 602 AALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVL 661
Query: 271 AHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLS 330
+ + + I+LA N + ++G +L+ + + L L+L S+ P+G +L+ +L
Sbjct: 662 S-GKDCRIQKISLAENQISNKGAKALARSLL-VNRSLTSLDLRGNSIGPQGAKALADALK 719
Query: 331 ANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGC 390
N TL L L GN +R D M LA + L L S+ + +
Sbjct: 720 IN----RTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKN--SIGPMGAQRMADA 773
Query: 391 LQYLAVLNLSRTVFSHRK-GKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLA 449
L+ +L +FS G + + + L ++L +S + AL+ L
Sbjct: 774 LKQNR--SLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALC 831
Query: 450 CNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL-ESDLSTLIVWLSKN 508
N L +SL L + GAQ + + + +LD++ N L + + V + +N
Sbjct: 832 TNQTL--LSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVREN 889
Query: 509 RSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEES-PLQSLSLADS---------KLKT 558
R++ L L NF + L +Q+ + S LQ ++ D K+ T
Sbjct: 890 RTLTSLHLQWNFIQAGAAQ---ALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
Query: 559 EVT---------------IIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRT 603
+T ++ AL N +L +D+ GN +G GAK LA AL++N+ LR
Sbjct: 947 ALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRR 1006
Query: 604 VIWDKNNITAQGFQDIAVAMEKNYTLRFMPIP---MYDA-----SQALKTN 646
+ +N++ G IA A+ N+ L+ + + + D+ S+A+KTN
Sbjct: 1007 LNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTN 1057
Score = 77.0 bits (188), Expect = 1e-13
Identities = 94/410 (22%), Positives = 174/410 (42%), Gaps = 43/410 (10%)
Query: 222 KLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTI 281
K+S + ++S + + R + + L L L + A+ LA AL N L ++
Sbjct: 670 KISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRT--LTSL 727
Query: 282 NLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVH 341
+L GN + D G S++ A + L L+L K S+ P G ++ +L N +L
Sbjct: 728 SLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQRMADALKQN----RSLKE 782
Query: 342 LDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSR 401
L S N + + L + LDL + S D AL+ +L+LS
Sbjct: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSIS-DAGVAALMGALCTNQTLLSLSL 841
Query: 402 TVFSHRKGKEVPPSFKQFFSSSLA----LMHINLSGTKLSPEPLKALLLGLACNHNLKGV 457
+ + P Q + +L L +++L+ L + +A+ + + N L
Sbjct: 842 ------RENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTL--T 893
Query: 458 SLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESD--------------LSTLIV 503
SL L +++G AQ L + ++TSLD+ +N + D L+ L +
Sbjct: 894 SLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYL 953
Query: 504 WLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDE--------ESPLQSLSLADSK 555
++ + LG+ ++ + + N + + + S L+ L+L ++
Sbjct: 954 QVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENS 1013
Query: 556 LKTEVTIII-NALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTV 604
L + I I AL N L +++ GN +GD GA+M+++A++ N TV
Sbjct: 1014 LGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTV 1063
Score = 60.8 bits (146), Expect = 8e-09
Identities = 61/225 (27%), Positives = 97/225 (43%), Gaps = 41/225 (18%)
Query: 448 LACNHNLKGVSLDLSNCELRSGGA-----------------QVLEGCIAEIHNITSLDIS 490
L C H L+ L S E GA QV + C E + SL +S
Sbjct: 568 LHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEAN--LSLSLS 625
Query: 491 DNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLS 550
L+S L L+ + L L N + PV++ L ++ ++ +Q +S
Sbjct: 626 QGVLQSLLPQLLY-------CRKLRLDTN------QFQDPVMELLGSVLSGKDCRIQKIS 672
Query: 551 LADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKN 609
LA++++ + + +L N SLT +D+ GN +G GAK LA AL+IN L ++ N
Sbjct: 673 LAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGN 732
Query: 610 NITAQGFQDIAVAMEKNYTLRFM--------PIPMYDASQALKTN 646
+ G + +A A+ N TL + P+ + ALK N
Sbjct: 733 TVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQN 777
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 69.3 bits (168), Expect = 2e-11
Identities = 66/251 (26%), Positives = 122/251 (48%), Gaps = 27/251 (10%)
Query: 446 LGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL-ESDLSTLIVW 504
L +H K ++LDL N L G + L+ C + + T L +S N + + + L
Sbjct: 695 LSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRL---TVLRLSVNQITDGGVKVLSEE 751
Query: 505 LSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TII 563
L+K + + +L L +NN +T V V I DE L L L +K+ +E +
Sbjct: 752 LTKYKIVTYLGL---YNNQ----ITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYL 804
Query: 564 INALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAM 623
A+ ++ S+++V + GN +GD GAK A+AL+ + L T+ N I+ +G + +A A+
Sbjct: 805 ALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARAL 864
Query: 624 EKNYTLRFMPIPMYDASQALKTNPEKTEDALQKIENYLLRNHETRKYLQEQAYRLQQGIV 683
++N +L + + T E ++ + + +L+ ++T K+L + +Q I
Sbjct: 865 QQNTSLEILWL----------TQNELNDEVAESLAE-MLKVNQTLKHL----WLIQNQIT 909
Query: 684 TSTTQQMIDRI 694
T Q+ D +
Sbjct: 910 AKGTAQLADAL 920
Score = 42.7 bits (99), Expect = 0.002
Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 7/106 (6%)
Query: 248 LEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGL 307
L L L + G+ T+ + LA AL N + L + L N L D SL+ + K+ + L
Sbjct: 842 LTTLSLASNGISTEGGKSLARALQQN--TSLEILWLTQNELNDEVAESLA-EMLKVNQTL 898
Query: 308 KHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
KHL L + ++ KG L+ +L +N + + + L+GN+++ ++
Sbjct: 899 KHLWLIQNQITAKGTAQLADALQSN----TGITEICLNGNLIKPEE 940
Score = 41.6 bits (96), Expect = 0.005
Identities = 40/159 (25%), Positives = 84/159 (52%), Gaps = 13/159 (8%)
Query: 426 LMHINLSGTKLSPEPLKALLLGLACNHNLKGVS-LDLSNCELRSGGAQVLEGCIAEIHNI 484
L H+ L K++ E K L L + N K +S + + ++ GA+ + ++
Sbjct: 786 LTHLKLGKNKITSEGGKYLALAVK---NSKSISEVGMWGNQVGDEGAKAFAEALRNHPSL 842
Query: 485 TSLDISDNGLESDLS-TLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEE 543
T+L ++ NG+ ++ +L L +N S++ L L +N N + V ++L +M++ +
Sbjct: 843 TTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDE------VAESLAEMLKVNQ 896
Query: 544 SPLQSLSLADSKLKTEVTI-IINALGSNTSLTKVDISGN 581
+ L+ L L +++ + T + +AL SNT +T++ ++GN
Sbjct: 897 T-LKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 63.2 bits (152), Expect = 2e-09
Identities = 72/253 (28%), Positives = 123/253 (48%), Gaps = 23/253 (9%)
Query: 422 SSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAE- 480
S++A+ + L + E + +L+ L N+ L+ +++SN L GA+++
Sbjct: 131 SNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQ--EMNISNNHLGLEGARIISDFFERN 188
Query: 481 IHNITSLDISDNGLESDLSTLIVW-LSKNRSIQHLALGKN-FNNMKSKNLTPVLDNLVQM 538
+I SL++S N + D + L+ LS N I+ L L N F+++ ++L +L V
Sbjct: 189 SSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVG- 247
Query: 539 IQDEESPLQSLSLADSKLKTEVTIII-NALGSNTSLTKVDISGNGMGDMGAKMLAKALQI 597
L SL L+ + T + + N L N +LTK+D+S NG G+ A L + L++
Sbjct: 248 -------LTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRL 300
Query: 598 NTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFM-----PIPMYDA---SQALKTNPEK 649
N L + N+I +G I+ +E N +LR + PI M A A+K NP+
Sbjct: 301 NRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKS 360
Query: 650 TEDALQKIENYLL 662
+ L I N L+
Sbjct: 361 RMEELD-ISNVLV 372
Score = 48.5 bits (114), Expect = 4e-05
Identities = 68/292 (23%), Positives = 119/292 (40%), Gaps = 22/292 (7%)
Query: 197 QDFSHLDHRDLIP-----IIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEEL 251
+ + +L+H L P I AL N TKL +D + + ++ ++ + L+E+
Sbjct: 107 ESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEM 166
Query: 252 VLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLN 311
+ N L + A+ ++ N +S + ++ L+GN ++ ++L Q +K L+
Sbjct: 167 NISNNHLGLEGARIISDFFERN-SSSIWSLELSGNDFKEDS-AALLCQALSTNYQIKKLD 224
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
LS S G L Q L+ N L LDLS N + N L + LD
Sbjct: 225 LSHNQFSDVGGEHLGQMLAIN----VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLD 280
Query: 372 LS----NTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
LS E +L + L CL YL + + G E + S+ +L
Sbjct: 281 LSMNGFGNEVALALGEVLRLNRCLVYL-------DIGGNDIGNEGASKISKGLESNESLR 333
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIA 479
+ L ++ + L+L + N + LD+SN + + L+G A
Sbjct: 334 VLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYA 385
Score = 41.2 bits (95), Expect = 0.007
Identities = 65/282 (23%), Positives = 116/282 (41%), Gaps = 45/282 (15%)
Query: 214 LEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEE--LVLENAGLRTDFAQKLASALA 271
+E ++ F K+L L ++ V +EE + L + GL + +A AL
Sbjct: 71 IEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALV 130
Query: 272 HNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSA 331
N + + L N + + GV SL ++ + L+ +N+S L +G +S
Sbjct: 131 SN--MAVTKLELEDNCIMEEGVLSL-VEMLQENYYLQEMNISNNHLGLEGARIISDFFER 187
Query: 332 NPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTE--------------- 376
N +S++ L+LSGN + D + + L+ I LDLS+ +
Sbjct: 188 N---SSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAI 244
Query: 377 ----CSLDM------------VCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFF 420
SLD+ +C LRG + L L+LS F G EV + +
Sbjct: 245 NVGLTSLDLSWNNFHTRGAVALCNG-LRGNVT-LTKLDLSMNGF----GNEVALALGEVL 298
Query: 421 SSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLS 462
+ L+++++ G + E + GL N +L+ + L L+
Sbjct: 299 RLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLN 340
Score = 32.0 bits (71), Expect = 4.0
Identities = 18/65 (27%), Positives = 34/65 (52%)
Query: 570 NTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTL 629
N + V+++ +G+G G K +A AL N + + + N I +G + +++NY L
Sbjct: 104 NMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYL 163
Query: 630 RFMPI 634
+ M I
Sbjct: 164 QEMNI 168
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 60.1 bits (144), Expect = 1e-08
Identities = 77/277 (27%), Positives = 126/277 (45%), Gaps = 17/277 (6%)
Query: 248 LEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGL 307
LE L L+ GL K++ L +P+ L +++LAGN + D+GV LS L
Sbjct: 868 LESLRLDCCGLTHACYLKISQILTTSPS--LKSLSLAGNKVTDQGVMPLSDALRVSQCAL 925
Query: 308 KHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAI 367
+ L L ++ G SL+ +L +N +L HL LS N L + ++ + + P+
Sbjct: 926 QKLILEDCGITATGCQSLASALVSN----RSLTHLCLSNNSLGNEGVNLLCRSMRLPHCS 981
Query: 368 VHLDLSNTECSLDMV-CGALLRGCL--QYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSL 424
+ + N +C LD CG L + +L L+LS K + ++ S
Sbjct: 982 LQRLMLN-QCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMRE---PSC 1037
Query: 425 ALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGG-AQVLEGCIAEIHN 483
L + L L+ ++L ++ + +LK SLDL++ L GG A + EG +
Sbjct: 1038 HLQDLELVKCHLTAACCESLSCVISRSRHLK--SLDLTDNALGDGGVAALCEGLKQKNSV 1095
Query: 484 ITSLDISDNGLESD-LSTLIVWLSKNRSIQHLALGKN 519
+ L + GL SD L + LS NR + L L +N
Sbjct: 1096 LARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQN 1132
Score = 46.6 bits (109), Expect = 2e-04
Identities = 81/373 (21%), Positives = 150/373 (40%), Gaps = 73/373 (19%)
Query: 264 QKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVN 323
+ S L +P+ L ++L + L +R + +L + ++ L ++P GV
Sbjct: 771 EDFCSMLGTHPH--LRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITP-GVQ 827
Query: 324 SLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVC 383
L + + AN L L+L G L+ +D+ L P ++ SL + C
Sbjct: 828 HLWRIVMAN----RNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE--------SLRLDC 875
Query: 384 GALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKA 443
L C YL + Q ++S +L ++L+G K++ + +
Sbjct: 876 CGLTHAC--YLKI--------------------SQILTTSPSLKSLSLAGNKVTDQGVMP 913
Query: 444 LLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIV 503
L +L +S C L+ +LE C I+ G +S S L+
Sbjct: 914 L-----------SDALRVSQCALQK---LILEDC----------GITATGCQSLASALV- 948
Query: 504 WLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTE-VTI 562
NRS+ HL L N + NL L + ++ LQ L L L T
Sbjct: 949 ---SNRSLTHLCLSNNSLGNEGVNL------LCRSMRLPHCSLQRLMLNQCHLDTAGCGF 999
Query: 563 IINALGSNTSLTKVDISGNGMGDMGAKMLAKAL-QINTKLRTVIWDKNNITAQGFQDIAV 621
+ AL N+ LT + +S N + D G K+L + + + + L+ + K ++TA + ++
Sbjct: 1000 LALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSC 1059
Query: 622 AMEKNYTLRFMPI 634
+ ++ L+ + +
Sbjct: 1060 VISRSRHLKSLDL 1072
Score = 33.1 bits (74), Expect = 1.8
Identities = 29/101 (28%), Positives = 44/101 (43%), Gaps = 2/101 (1%)
Query: 230 LSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLE 289
L+ CE + V+SRS L+ L L + L L L NS L + L L
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQK-NSVLARLGLKACGLT 1107
Query: 290 DRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLS 330
+LS+ + + L LNL + + SPKG+ L + +
Sbjct: 1108 SDCCEALSLALS-CNRHLTSLNLVQNNFSPKGMMKLCSAFA 1147
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 54.7 bits (130), Expect = 6e-07
Identities = 90/353 (25%), Positives = 140/353 (39%), Gaps = 67/353 (18%)
Query: 320 KGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQP---NAIVH-LDLSNT 375
K +N L S+S++ L + L+ S + D H +N + N +H LDLSN+
Sbjct: 682 KRLNKLRLSVSSHILERDLEI-LETS----KFDSRMHAWNSICSTLVTNENLHELDLSNS 736
Query: 376 ECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQ-----FFSSSLALMHIN 430
+ V G L L R K V P + + L H+N
Sbjct: 737 KLHASSVKGLCL--------ALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLN 788
Query: 431 LSGTKLS---PEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
S KL P LKAL ACN L L C L + Q L + I ++T L
Sbjct: 789 FSSNKLGMTVPLILKALRHS-ACNLKY----LCLEKCNLSAASCQDLALFLTSIQHVTRL 843
Query: 488 DISDNGLESD---------------LSTLIVW---------------LSKNRSIQHLALG 517
+ N L+ D L L +W L +NRS+ HL L
Sbjct: 844 CLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLS 903
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTE-VTIIINALGSNTSLTKV 576
KN +++ + + L + + + LQSL+L+ E + NAL N ++ +
Sbjct: 904 KN--SLRDEGVK----FLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKIL 957
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTL 629
D+ N + D G K+L +AL+ + L T+ K N+T Q + + + +L
Sbjct: 958 DLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSL 1010
Score = 51.2 bits (121), Expect = 6e-06
Identities = 97/396 (24%), Positives = 164/396 (41%), Gaps = 60/396 (15%)
Query: 222 KLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTI 281
+L+ L +S+ + E+ L ++ S + N+ + S L N N LH +
Sbjct: 683 RLNKLRLSVSSHILERDLEILETSKFDSRMHAWNS---------ICSTLVTNEN--LHEL 731
Query: 282 NLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGV-NSLSQSLSANPLTASTLV 340
+L+ + L V L + K P+ K L+ S++P+ V L +L N S L
Sbjct: 732 DLSNSKLHASSVKGLCLAL-KNPR-CKVQKLTCKSVTPEWVLQDLIIALQGN----SKLT 785
Query: 341 HLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGC-LQYLAVLNL 399
HL+ S N L ++ L ++ C+L +C L C L + +L
Sbjct: 786 HLNFSSNKL------------GMTVPLILKALRHSACNLKYLC---LEKCNLSAASCQDL 830
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLA---CNH---- 452
+ + S + + F + + L+ L+ K + E L+ LA C H
Sbjct: 831 ALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDA 890
Query: 453 ---NLKGVSLDLSNCELRSGGAQVL-EGCIAEIHNITSLDISDNGLESD-LSTLIVWLSK 507
N L+LS LR G + L E N+ SL++S + L LS
Sbjct: 891 LLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSH 950
Query: 508 NRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESP---LQSLSLADSKLKTEVTI-I 563
N +++ L LG+N + D+ V+++ + P L +L LA L T +
Sbjct: 951 NHNVKILDLGEN----------DLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHL 1000
Query: 564 INALGSNTSLTKVDISGNGMGDMGAKMLAKALQINT 599
+ L S+ SL +++ GN + G KML KAL+ +T
Sbjct: 1001 FSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKST 1036
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 53.9 bits (128), Expect = 1e-06
Identities = 97/372 (26%), Positives = 152/372 (40%), Gaps = 34/372 (9%)
Query: 254 ENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLS 313
E L +++ LA+AL NPN L ++L N L RGV L L++L L
Sbjct: 693 ERTVLLDAYSEHLAAALCTNPN--LIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLK 750
Query: 314 KTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLS 373
+ +S LS +L AN L +DLSGN + + + L P + + +
Sbjct: 751 RCRISSSACEDLSAALIAN----KNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQM-IQ 805
Query: 374 NTECSLDM-VCG--ALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHIN 430
+C L+ C A + G +L L+L+ + + + L +
Sbjct: 806 LRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRH---PVCRLRTLW 862
Query: 431 LSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDIS 490
L +L+ L L+ N +L+ LDLS EL G +L C H L
Sbjct: 863 LKICRLTAAACDELASTLSVNQSLR--ELDLSLNELGDLGVLLL--CEGLRHPTCKLQTL 918
Query: 491 DNGL----ESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPL 546
G+ + L V L N +++ L L +FN++ L + + L Q L
Sbjct: 919 RLGICRLGSAACEGLSVVLQANHNLRELDL--SFNDLGDWGLWLLAEGL----QHPACRL 972
Query: 547 QSLSLADSKLKTEVTI-IINALGSNTSLTKVDISGNGMGDMGAKMLAKAL-QINTKLRTV 604
Q L L L + + LG N +LT + ++ N +GD G ++L K L KLR V
Sbjct: 973 QKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLR-V 1031
Query: 605 IW----DKNNIT 612
+W D N +T
Sbjct: 1032 LWLFGMDLNKMT 1043
Score = 48.9 bits (115), Expect = 3e-05
Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 34/212 (16%)
Query: 426 LMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNIT 485
L+ ++L L +K L GL + N K +L L C + S + L + N+T
Sbjct: 715 LIELSLYRNALGSRGVKLLCQGLR-HPNCKLQNLRLKRCRISSSACEDLSAALIANKNLT 773
Query: 486 SLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESP 545
+D+S NG+ L+ ++H +QMIQ +
Sbjct: 774 RMDLSGNGVGFPGMMLLC-----EGLRHPQCR------------------LQMIQLRKCQ 810
Query: 546 LQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINT-KLRTV 604
L+S + + + + LG+N L ++D++GN + D+G ++L + L+ +LRT+
Sbjct: 811 LESGACQE---------MASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 861
Query: 605 IWDKNNITAQGFQDIAVAMEKNYTLRFMPIPM 636
+TA ++A + N +LR + + +
Sbjct: 862 WLKICRLTAAACDELASTLSVNQSLRELDLSL 893
Score = 38.5 bits (88), Expect = 0.043
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 6/103 (5%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RL+ + L L + Q++AS L NP+ L ++L GN LED G+ L
Sbjct: 800 RLQMIQLRKCQLESGACQEMASVLGTNPH--LVELDLTGNALEDLGLRLLCQGLRHPVCR 857
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVL 349
L+ L L L+ + L+ +LS N +L LDLS N L
Sbjct: 858 LRTLWLKICRLTAAACDELASTLSVN----QSLRELDLSLNEL 896
Score = 35.0 bits (79), Expect = 0.48
Identities = 31/124 (25%), Positives = 61/124 (49%), Gaps = 8/124 (6%)
Query: 505 LSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVTIII 564
L N ++ L+L +N + L L Q ++ LQ+L L ++ + +
Sbjct: 709 LCTNPNLIELSLYRNALGSRGVKL------LCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
Query: 565 NA-LGSNTSLTKVDISGNGMGDMGAKMLAKALQ-INTKLRTVIWDKNNITAQGFQDIAVA 622
+A L +N +LT++D+SGNG+G G +L + L+ +L+ + K + + Q++A
Sbjct: 763 SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 822
Query: 623 MEKN 626
+ N
Sbjct: 823 LGTN 826
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 53.5 bits (127), Expect = 1e-06
Identities = 74/310 (23%), Positives = 131/310 (42%), Gaps = 57/310 (18%)
Query: 330 SANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECS---LDMVCGAL 386
S++ + LV+ L+ + RG +++ L+ ++ LDLS+ + ++C L
Sbjct: 711 SSHAACSHGLVNSHLTSSFCRG-----LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETL 765
Query: 387 LR-GCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALL 445
GC + L L R SH E SS+ L+ ++LS L ++ L
Sbjct: 766 QHPGC--NIRRLWLGRCGLSH----ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 819
Query: 446 LGLA---CNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLI 502
+GL CN LK L L +C L S Q L ++ H++T L + +N L ++
Sbjct: 820 VGLKHLLCN--LK--KLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAIL 875
Query: 503 VWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-T 561
+KN + LQ L L +S L + +
Sbjct: 876 CEKAKN---------------------------------PQCNLQKLGLVNSGLTSVCCS 902
Query: 562 IIINALGSNTSLTKVDISGNGMGDMGAKMLAKA-LQINTKLRTVIWDKNNITAQGFQDIA 620
+ + L +N +LT + + GN +GD G K+L + L + KL+ + D N+T+ D++
Sbjct: 903 ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS 962
Query: 621 VAMEKNYTLR 630
+ + +LR
Sbjct: 963 TLLTSSQSLR 972
Score = 35.0 bits (79), Expect = 0.48
Identities = 44/177 (24%), Positives = 74/177 (41%), Gaps = 18/177 (10%)
Query: 455 KGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHL 514
+G LD+ C L S + H +S GL S LST ++S+ L
Sbjct: 697 EGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFC---RGLFSVLST-------SQSLTEL 746
Query: 515 ALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVTIIIN-ALGSNTSL 573
L N P + L + +Q ++ L L L E I+ L SN L
Sbjct: 747 DLSDNSLG------DPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL 800
Query: 574 TKVDISGNGMGDMGAKMLAKALQ-INTKLRTVIWDKNNITAQGFQDIAVAMEKNYTL 629
++D+S N +GD G ++L L+ + L+ + +T+ QD+A + +++L
Sbjct: 801 VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSL 857
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 53.5 bits (127), Expect = 1e-06
Identities = 74/310 (23%), Positives = 131/310 (42%), Gaps = 57/310 (18%)
Query: 330 SANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECS---LDMVCGAL 386
S++ + LV+ L+ + RG +++ L+ ++ LDLS+ + ++C L
Sbjct: 711 SSHAACSHGLVNSHLTSSFCRG-----LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETL 765
Query: 387 LR-GCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALL 445
GC + L L R SH E SS+ L+ ++LS L ++ L
Sbjct: 766 QHPGC--NIRRLWLGRCGLSH----ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 819
Query: 446 LGLA---CNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLI 502
+GL CN LK L L +C L S Q L ++ H++T L + +N L ++
Sbjct: 820 VGLKHLLCN--LK--KLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAIL 875
Query: 503 VWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-T 561
+KN + LQ L L +S L + +
Sbjct: 876 CEKAKN---------------------------------PQCNLQKLGLVNSGLTSVCCS 902
Query: 562 IIINALGSNTSLTKVDISGNGMGDMGAKMLAKA-LQINTKLRTVIWDKNNITAQGFQDIA 620
+ + L +N +LT + + GN +GD G K+L + L + KL+ + D N+T+ D++
Sbjct: 903 ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS 962
Query: 621 VAMEKNYTLR 630
+ + +LR
Sbjct: 963 TLLTSSQSLR 972
Score = 35.0 bits (79), Expect = 0.48
Identities = 44/177 (24%), Positives = 74/177 (41%), Gaps = 18/177 (10%)
Query: 455 KGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHL 514
+G LD+ C L S + H +S GL S LST ++S+ L
Sbjct: 697 EGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFC---RGLFSVLST-------SQSLTEL 746
Query: 515 ALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVTIIIN-ALGSNTSL 573
L N P + L + +Q ++ L L L E I+ L SN L
Sbjct: 747 DLSDNSLG------DPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL 800
Query: 574 TKVDISGNGMGDMGAKMLAKALQ-INTKLRTVIWDKNNITAQGFQDIAVAMEKNYTL 629
++D+S N +GD G ++L L+ + L+ + +T+ QD+A + +++L
Sbjct: 801 VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSL 857
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 52.8 bits (125), Expect = 2e-06
Identities = 87/368 (23%), Positives = 151/368 (41%), Gaps = 61/368 (16%)
Query: 295 SLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDL 354
S I F++ + K L LS+ S P+ V+ L+ LS + L L L+ L L
Sbjct: 1313 SFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS----LQLTELTLTQCCLGQKQL 1368
Query: 355 SHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQY---LAVLNLSRTV------FS 405
+ + + + +P + L + V +LL C Q + +++S T
Sbjct: 1369 AILLSLVGRPAGLFSLRVQEPWADRARVL-SLLEVCAQASGSVTEISISETQQQLCVQLE 1427
Query: 406 HRKGKEVPPSFK-----------------QFFSSSLALMHINLSGTKLSPEP------LK 442
+ +E P + Q + L ++LS L + L+
Sbjct: 1428 FPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQ 1487
Query: 443 ALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLI 502
+LLL L+ LK L S+C G A + G + H++ LD+S+N + + + +
Sbjct: 1488 SLLLSLS---ELKTFRLT-SSCVSTEGLAHLASG-LGHCHHLEELDLSNNQFDEEGTKAL 1542
Query: 503 V------WLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKL 556
+ W+ K + HL L S L + L QM + LQSL L + +
Sbjct: 1543 MRALEGKWMLKRLDLSHLLLN-------SSTLALLTHRLSQM-----TCLQSLRLNRNSI 1590
Query: 557 -KTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQG 615
+ AL + TSL ++D+S N +GD G + LA L +LR + N+I++ G
Sbjct: 1591 GDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAG 1650
Query: 616 FQDIAVAM 623
+A ++
Sbjct: 1651 GVQLAESL 1658
Score = 47.8 bits (112), Expect = 7e-05
Identities = 90/385 (23%), Positives = 156/385 (40%), Gaps = 45/385 (11%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSG-LHTINLAGNPLEDRGVSSLSIQFAKLPK 305
++E L ++ FA+ L+ +L P G L + LAG+ + RG+S L P+
Sbjct: 687 QIENLSFKSRKCGDAFAEALSRSL---PTMGRLQMLGLAGSKITARGISHLVKALPLCPQ 743
Query: 306 GLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPN 365
LK ++ LS + V ++ + L P L LDLS N + L
Sbjct: 744 -LKEVSFRDNQLSDQVVLNIVEVLPHLP----RLRKLDLSSNSICVSTL----------- 787
Query: 366 AIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLA 425
L L+ + V R + + T ++ ++ S Q +
Sbjct: 788 ----LCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSR 843
Query: 426 LMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNIT 485
+ + L +L +AL+ L +L+ V DLS +L G +++ +++H
Sbjct: 844 SLTLRLQKCQLQVHDAEALIALLQEGPHLEEV--DLSGNQLEDEGCRLMAEAASQLHIAR 901
Query: 486 SLDISDNGLE--------SDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTP-----VL 532
LD+SDNGL +S + S+QH + F + P L
Sbjct: 902 KLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFL 961
Query: 533 DNLVQMIQDEESPLQS--LSLADSKLKTE-VTIIINALGSNTSL--TKVDISGNGMGDMG 587
D+L+ + E PL S + L L+ + + + ALG + L +D SGN +GD G
Sbjct: 962 DSLM-LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEG 1020
Query: 588 AKMLAKALQINTKLRTVIWDKNNIT 612
A LA+ L L+++ +N ++
Sbjct: 1021 AARLAQLLPGLGALQSLNLSENGLS 1045
Score = 47.4 bits (111), Expect = 9e-05
Identities = 76/319 (23%), Positives = 126/319 (39%), Gaps = 29/319 (9%)
Query: 334 LTASTLVH-LDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQ 392
LTA +L + L L DL+ + N L A +HLD C L+ C L GC Q
Sbjct: 630 LTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDG--CPLEPHCPEALVGCGQ 687
Query: 393 YLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALMH----INLSGTKLSPEPLKALLLGL 448
+ NLS K ++ +F + S SL M + L+G+K++ + L+ L
Sbjct: 688 ---IENLSF------KSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKAL 738
Query: 449 ACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESD----LSTLIVW 504
LK VS + +L + + + + LD+S N + L+ + V
Sbjct: 739 PLCPQLKEVSF--RDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVT 796
Query: 505 LSKNRSIQHLALGKNFNNMKSKNLTPVLDNL--VQMIQDEESPLQSLSLADSKLKTEVTI 562
R +Q F T L +Q + QS SL K ++ +
Sbjct: 797 CPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQV 856
Query: 563 -----IINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQ 617
+I L L +VD+SGN + D G +++A+A R + N ++ G
Sbjct: 857 HDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVH 916
Query: 618 DIAVAMEKNYTLRFMPIPM 636
+ A+ +TL + I +
Sbjct: 917 CVLRAVSACWTLAELHISL 935
Score = 45.8 bits (107), Expect = 3e-04
Identities = 64/242 (26%), Positives = 103/242 (42%), Gaps = 27/242 (11%)
Query: 426 LMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNIT 485
L L+ + +S E L L GL H+L+ LDLSN + G + L + +
Sbjct: 1496 LKTFRLTSSCVSTEGLAHLASGLGHCHHLE--ELDLSNNQFDEEGTKALMRALEGKWMLK 1553
Query: 486 SLDISDNGLESDLSTLIVW-LSKNRSIQHLALGKN-FNNMKSKNLTPVLDNLVQMIQDEE 543
LD+S L S L+ LS+ +Q L L +N ++ +L+ L + EE
Sbjct: 1554 RLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSL---EE 1610
Query: 544 SPLQSLSLADSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRT 603
L + D+ ++ TI L L K+D+SGN + G LA++L + +L
Sbjct: 1611 LDLSHNQIGDAGVQHLATI----LPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEE 1666
Query: 604 VIWDKNNI---TAQGFQDIAVAMEKNYTLRFMPIPM--------YDASQALKTNPEKTED 652
++ N + TA G +A E LR + +P +QAL +P E
Sbjct: 1667 LMLGCNALGDPTALG-----LAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEI 1721
Query: 653 AL 654
+L
Sbjct: 1722 SL 1723
Score = 45.1 bits (105), Expect = 5e-04
Identities = 80/338 (23%), Positives = 133/338 (39%), Gaps = 41/338 (12%)
Query: 284 AGNPLEDRG-------VSSLSIQF-AKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLT 335
A P E +G + SL +Q ++LP + + L+ L K + L ++L +
Sbjct: 945 AQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHL 1004
Query: 336 ASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLR--GCLQY 393
+HLD SGN L + + + L A+ L+LS SLD V G L+R LQ+
Sbjct: 1005 GH--LHLDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLG-LVRCFSTLQW 1061
Query: 394 LAVLNL--------------SRTVFSHRKGKEVPPSFKQF-FSSSLALMHINLSGTKLSP 438
L L++ SR +++ + P + K F + LS L P
Sbjct: 1062 LFRLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEP 1121
Query: 439 EPLKALLLGLA-CNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESD 497
L L L C L+ L LS L + L C+ ++ ++ L +S GL
Sbjct: 1122 PSLTRLCATLKDCPGPLE---LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPK 1178
Query: 498 LSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLK 557
L+ L+L + ++L + + ++EE S +
Sbjct: 1179 SPFLLA--------NTLSLCPRVKKVDLRSLHHATLHF-RSNEEEEGVCCGRFTGCSLSQ 1229
Query: 558 TEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKAL 595
V + L L++VD+S N +GD G + L + L
Sbjct: 1230 EHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECL 1267
Score = 41.2 bits (95), Expect = 0.007
Identities = 93/408 (22%), Positives = 166/408 (40%), Gaps = 79/408 (19%)
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L+LS+ +L ++ S L + L+ S L L+ + + + L+H+ + L +
Sbjct: 1465 LQQLSLSQVNLCEDD-DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHH 1523
Query: 367 IVHLDLSNTECSLDMVCGALLRGC--LQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSL 424
+ LDLSN + + AL+R L L+LS + + SS+L
Sbjct: 1524 LEELDLSNNQFDEEGT-KALMRALEGKWMLKRLDLSHLLLN---------------SSTL 1567
Query: 425 ALMHINLSG-TKLSPEPLKALLLG-LACNHNLKGV-------SLDLSNCELRSGGAQVLE 475
AL+ LS T L L +G + C H + + LDLS+ ++ G Q L
Sbjct: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627
Query: 476 GCIAEIHNITSLDISDNGLESDLST-LIVWLSKNRSIQHLALGKN-FNNMKSKNLTPVLD 533
+ + + +D+S N + S L L R ++ L LG N + + L L
Sbjct: 1628 TILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELP 1687
Query: 534 NLVQMIQ------------------DEESPLQSLSLADSKLKTEVT-------------- 561
++++ D L+ +SLA++ L V
Sbjct: 1688 QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDL 1747
Query: 562 -----------IIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNN 610
++ ++ S +L + +S N +GD A LA+ L +L+ V +KN
Sbjct: 1748 VSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQ 1807
Query: 611 ITAQGFQDIAVAMEKNYTLRFM-----PIPMYDASQALKTNPEKTEDA 653
ITA G +A + + +++ + PIP D +Q LK+ + + A
Sbjct: 1808 ITALGAWLLAEGLAQGSSIQVIRLWNNPIPC-DMAQHLKSQEPRLDFA 1854
Score = 38.5 bits (88), Expect = 0.043
Identities = 96/412 (23%), Positives = 162/412 (39%), Gaps = 66/412 (16%)
Query: 224 SSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINL 283
++ +L+ + D+ E + +R L L+ L+ A+ L + L P+ L ++L
Sbjct: 820 TTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPH--LEEVDL 877
Query: 284 AGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLD 343
+GN LED G ++ ++L K L+LS LS GV+ + +++SA TL L
Sbjct: 878 SGNQLEDEGCRLMAEAASQLHIARK-LDLSDNGLSVAGVHCVLRAVSA----CWTLAELH 932
Query: 344 LSGNVLRGDDLSH---MYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLS 400
+S L H ++ F +P LD + LQ + L LS
Sbjct: 933 IS--------LQHKTVIFMFAQEPEE--QKGPQERAAFLDSL-------MLQMPSELPLS 975
Query: 401 ----RTVFSHRKGKEVPPSFKQFFSS-SLALMHINLSGTKLSPE---PLKALLLGLACNH 452
R + K + K S L +H++ SG L E L LL GL
Sbjct: 976 SRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQ 1035
Query: 453 NLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNG----LESDLSTLIVWLSKN 508
SL+LS L L C + + + LDIS L D ++ +W +
Sbjct: 1036 -----SLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWAT-- 1088
Query: 509 RSIQHLALGKNFNNMKSKNL------------TPVLDNLVQMIQDEESPLQ-SLS---LA 552
S+ F + + + P L L ++D PL+ LS L+
Sbjct: 1089 GSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLS 1148
Query: 553 DSKLKTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTV 604
D L+T +++ L L+ + +S G+ +LA L + +++ V
Sbjct: 1149 DQSLET----LLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKV 1196
Score = 37.7 bits (86), Expect = 0.074
Identities = 78/291 (26%), Positives = 113/291 (38%), Gaps = 42/291 (14%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNL 312
L + GL+ ++L AL + + G ++ +GN L D G + L+ Q L+ LNL
Sbjct: 981 LTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNL 1039
Query: 313 SKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGN----VLRGD-------------DLS 355
S+ LS V L + S T L LD+S +LRGD D
Sbjct: 1040 SENGLSLDAVLGLVRCFS----TLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDFP 1095
Query: 356 HMYNFLAQPNAIVHLDLSNTEC-----SLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGK 410
FL + L +EC SL +C A L+ C L L LS S + +
Sbjct: 1096 AAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLC-ATLKDCPGPLE-LQLSCEFLSDQSLE 1153
Query: 411 EVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL-DLSNCELRSG 469
+ Q SL + LS T LSP+ L L+ +K V L L + L
Sbjct: 1154 TLLDCLPQLPQLSL----LQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFR 1209
Query: 470 GAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVW-LSKNRSIQHLALGKN 519
+ EG T +S +ES + W LSK + + + L N
Sbjct: 1210 SNEEEEGVCC--GRFTGCSLSQEHVES-----LCWLLSKCKDLSQVDLSAN 1253
Score = 36.6 bits (83), Expect = 0.16
Identities = 38/142 (26%), Positives = 59/142 (41%), Gaps = 28/142 (19%)
Query: 235 CEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVS 294
C + + + LEEL L + + Q LA+ L P L I+L+GN + G
Sbjct: 1595 CCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE--LRKIDLSGNSISSAGGV 1652
Query: 295 SLSIQFA-------------------------KLPKGLKHLNLSKTSLSPKGVNSLSQSL 329
L+ +LP+ L+ L+L + L P G SL+Q+L
Sbjct: 1653 QLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQAL 1712
Query: 330 SANP-LTASTLVHLDLSGNVLR 350
+P L +L +L+G VLR
Sbjct: 1713 DGSPHLEEISLAENNLAGGVLR 1734
>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
Length = 419
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/213 (23%), Positives = 98/213 (46%), Gaps = 11/213 (5%)
Query: 418 QFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGC 477
+ L L+++NL + PE + + L N LK L ++ ++ + G
Sbjct: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLK--YLRMTGNKIENKGGMFFAAM 189
Query: 478 IAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQ 537
+ ++ LD+ D LE + L +N + L + K+ ++K+ + + D L
Sbjct: 190 LQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKH--DIKNSGIQQLCDALYL 247
Query: 538 MIQDEESPLQSLSLADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKAL- 595
S L+ L ++ +K+ + + + + L SNT+L +D+S N + + GA L++ L
Sbjct: 248 -----NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLT 302
Query: 596 QINTKLRTVIWDKNNITAQGFQDIAVAMEKNYT 628
N L+ + NNI +G ++ +M+ N T
Sbjct: 303 SHNRSLKALSVVSNNIEGEGLVALSQSMKTNLT 335
Score = 33.9 bits (76), Expect = 1.1
Identities = 35/143 (24%), Positives = 68/143 (47%), Gaps = 15/143 (10%)
Query: 505 LSKNRSIQHLALGKNFNNM---KSKNLTPVLDNLVQMIQDE-ESPLQS---LSLADSKLK 557
L+ R L K+++N+ KS+ + P + +++Q + +E + L + L++A +
Sbjct: 29 LAVQRESPESGLQKHYSNLCMEKSQKINPFILHILQEVDEEIKKGLAAGITLNIAGNNRL 88
Query: 558 TEVT--------IIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKN 609
V I+ L + + +D+ N + D+GA AK LQ L + N
Sbjct: 89 VPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFN 148
Query: 610 NITAQGFQDIAVAMEKNYTLRFM 632
+I +G + IA + KN TL+++
Sbjct: 149 DIGPEGGELIAKVLHKNRTLKYL 171
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 48.9 bits (115), Expect = 3e-05
Identities = 56/203 (27%), Positives = 86/203 (42%), Gaps = 14/203 (6%)
Query: 430 NLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLD- 488
+L T S P + L H + V+L L + G + L C+ + D
Sbjct: 766 HLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDN 825
Query: 489 -ISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQ 547
ISD G+ LI +Q LAL FNN + + L+ Q+
Sbjct: 826 NISDRGI----CKLIECALHCEQLQKLAL---FNNKLTDGCAHSMAKLLACRQN----FL 874
Query: 548 SLSLADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIW 606
+L L ++ + ++ L NTSL + GN +GD GA+ LA+AL + LR +
Sbjct: 875 ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSL 934
Query: 607 DKNNITAQGFQDIAVAMEKNYTL 629
NNI + G Q +A+ + KN L
Sbjct: 935 VGNNIGSVGAQALALMLAKNVML 957
Score = 43.9 bits (102), Expect = 0.001
Identities = 26/97 (26%), Positives = 51/97 (52%), Gaps = 4/97 (4%)
Query: 563 IINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVA 622
+ ALG + SL + + GN +G +GA+ LA L N L + ++N++ +G +A
Sbjct: 919 LAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEG 978
Query: 623 MEKNYTLRFMPIP----MYDASQALKTNPEKTEDALQ 655
++KN +L+ + + Y ++AL E+ + L+
Sbjct: 979 LKKNSSLKILKLSNNCITYLGAEALLQALERNDTILE 1015
Score = 40.8 bits (94), Expect = 0.009
Identities = 49/188 (26%), Positives = 87/188 (46%), Gaps = 14/188 (7%)
Query: 426 LMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNIT 485
L + L KL+ ++ LAC N ++L L N + + GAQVL + ++
Sbjct: 845 LQKLALFNNKLTDGCAHSMAKLLACRQNF--LALRLGNNYITAAGAQVLAEGLRGNTSLQ 902
Query: 486 SLDISDNGL-ESDLSTLIVWLSKNRSIQHLAL-GKNFNNMKSKNLTPVLDNLVQMIQDEE 543
L N + + L L ++S++ L+L G N ++ ++ L +L V
Sbjct: 903 FLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVM------ 956
Query: 544 SPLQSLSLADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLR 602
L+ L L ++ L+ E V + L N+SL + +S N + +GA+ L +AL+ N +
Sbjct: 957 --LEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTIL 1014
Query: 603 TVIWDKNN 610
V W + N
Sbjct: 1015 EV-WLRGN 1021
Score = 32.7 bits (73), Expect = 2.4
Identities = 26/115 (22%), Positives = 57/115 (49%), Gaps = 6/115 (5%)
Query: 521 NNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVT-IIINALGSNTSLTKVDIS 579
NN+ + + +++ + Q LQ L+L ++KL + L + + +
Sbjct: 825 NNISDRGICKLIECALHCEQ-----LQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLG 879
Query: 580 GNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPI 634
N + GA++LA+ L+ NT L+ + + N + +G Q +A A+ + +LR++ +
Sbjct: 880 NNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSL 934
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 48.9 bits (115), Expect = 3e-05
Identities = 52/194 (26%), Positives = 94/194 (48%), Gaps = 20/194 (10%)
Query: 446 LGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIH---NITSLDISDNGLES----DL 498
+ L + N K V LDLS+ L G ++L C+ H N+ L + L S DL
Sbjct: 733 ISLVLSSNQKLVELDLSDNALGDFGIRLL--CVGLKHLLCNLKKLWLVSCCLTSACCQDL 790
Query: 499 STLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKT 558
+++ LS + S+ L +G+N + L + ++ + LQ L L +S L +
Sbjct: 791 ASV---LSTSHSLTRLYVGENALGDSGVAI------LCEKAKNPQCNLQKLGLVNSGLTS 841
Query: 559 EV-TIIINALGSNTSLTKVDISGNGMGDMGAKMLAKA-LQINTKLRTVIWDKNNITAQGF 616
+ + + L +N +LT + + GN +GD G K+L + L + KL+ + D N+T+
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
Query: 617 QDIAVAMEKNYTLR 630
D++ + + +LR
Sbjct: 902 WDLSTLLTSSQSLR 915
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 48.9 bits (115), Expect = 3e-05
Identities = 84/367 (22%), Positives = 141/367 (38%), Gaps = 36/367 (9%)
Query: 967 SSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDEGV 1026
++GF SE+ + + + P + K+Q T+++ +++ +S D + M ++ +
Sbjct: 1344 NTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSS-NQSI 1402
Query: 1027 DEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTI 1086
V + S++ S+ S S E+ +G R SR S R S P
Sbjct: 1403 SSPVLDAVPRTPSRERSSSAS-SPEMKDGLPRTPSRRSRSGSS----PGLRDGSGTPSRH 1457
Query: 1087 LMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKV--- 1143
++ K R+P + + + + + + P S S E K
Sbjct: 1458 SLSGSSPGMKDIPRTPS-----RGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTP 1512
Query: 1144 --ERSDSKSSPQ---AGRRYGVQVMGSGLLAEMKAK-----QENRFGLGTPEKNTKAEPK 1193
ERS S+SS R Q SG E+ K QE +P+ +KA+ +
Sbjct: 1513 QRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPD--SKAKTR 1570
Query: 1194 AEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDS---PSSPKVA 1250
RSRS SS K L + + P + KPR A R DS P +P
Sbjct: 1571 TPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPR 1630
Query: 1251 LLPPVLKKVPSDKER----DGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDG 1306
LP + S K R +G SS + SP R+ + ++ E K +S +
Sbjct: 1631 ALPRRSRSGSSSKGRGPSPEGSSSTESSP---EHPPKSRTARRGSRSSPEPKTKSRTPPR 1687
Query: 1307 HQGSKSN 1313
+ S+S+
Sbjct: 1688 RRSSRSS 1694
Score = 48.1 bits (113), Expect = 5e-05
Identities = 111/475 (23%), Positives = 182/475 (38%), Gaps = 47/475 (9%)
Query: 864 LADHFSRRG---KTLPQQESLEIELAEEKPVKRSIITV-------------EELTEIERL 907
+ DH +R + L +E +E + EE+ ++ + T +E T +R
Sbjct: 57 ILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRP 116
Query: 908 EDLDTCMMTPKSKRKSIHSRMLRPVSRAFE--MEFDLDKALEEVPIHIEDPPFP-SLRQE 964
+T + +++K+ R +S ++ FD + E +PP P SL +E
Sbjct: 117 AVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRE 176
Query: 965 KRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDE 1024
SS S P ++ KK + K R +R++ P + ++ E +
Sbjct: 177 SSSSR--SPTPKQKKKKKK---KDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRS 231
Query: 1025 GVDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPP 1084
+ +K+ +K D K+ +R + + DS SS + +SRS + +
Sbjct: 232 PTPK--SKRKSK-DKKRKRSRSTTPAPKSRRAHRSTSADSASSSD-TSRSRSRSAAAKTH 287
Query: 1085 TILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKVE 1144
T + SP R D P + S K P S E + ++ K E
Sbjct: 288 TTALAGRSPSPASGRRGEG-DAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKD--KKE 344
Query: 1145 RSDSKSSPQAGRRY-GVQVMG-SGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAG-SRSR 1201
+S ++ SP R G + + LLAE TP P +EA +R R
Sbjct: 345 KSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLAT-TPLSQEPVNPPSEASPTRDR 403
Query: 1202 SSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKV-- 1259
S P SP+ L QS S + P PQ P SR SP SPK A P +++
Sbjct: 404 SP---PKSPEKLPQSS--SSESSPPSPQ-PTKVSR--HASSSPESPKPAPAPGSHREISS 455
Query: 1260 -PSDKERD-GQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKS 1312
P+ K R G++ S RS + + R+ +K GH S+S
Sbjct: 456 SPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRS 510
Score = 43.5 bits (101), Expect = 0.001
Identities = 81/343 (23%), Positives = 122/343 (35%), Gaps = 32/343 (9%)
Query: 989 RPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDEGVDEFFTKKVTKMDSKKWSTRGSE 1048
RP+ P C ++ E++G VD+ K V + + S GS
Sbjct: 1494 RPRSRSPSSPELNNKC----LTPQRERSGSESSVDQ-------KTVARTPLGQRSRSGS- 1541
Query: 1049 SHELN----EGGDEKKKRDSRKSSGFLNL--IKSRSKSERPPTILMTEEPSSPKGAVRSP 1102
S EL+ E+ + DS S ++ RS+S P + S + S
Sbjct: 1542 SQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSS 1601
Query: 1103 PVDCPRKDTKAAEHNGNSERIEEIKTPD---------SFEESQGEEIGKVERSDSKSSPQ 1153
P + K A S+ E K P S S+G S ++SSP+
Sbjct: 1602 P-EVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPE 1660
Query: 1154 AGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPL 1213
+ GS E K K + + + KA RSRS+SS SP+
Sbjct: 1661 HPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASS---SPETR 1717
Query: 1214 LQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQP 1273
++P + V +P SR S SSP+ + PS K R Q S
Sbjct: 1718 SRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSR-RGRSPSPKPRGLQRSRSR 1776
Query: 1274 SPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSG 1316
S R ++ RR +Q ++QRS S+ + SG
Sbjct: 1777 SRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSG 1819
Score = 41.2 bits (95), Expect = 0.007
Identities = 63/292 (21%), Positives = 100/292 (34%), Gaps = 37/292 (12%)
Query: 1039 SKKWSTRG-SESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTI----------- 1086
S+ +TRG S S G + + +R+ S + RS+S P
Sbjct: 564 SRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR 623
Query: 1087 -LMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGK--- 1142
T P + RSP R ++ G S + S + G+
Sbjct: 624 RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRS 683
Query: 1143 ---VERSDSKS-SPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAGS 1198
R S+S +P+ GR ++ G ++ R G + KN K+
Sbjct: 684 RTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKN-----KSRTSQ 738
Query: 1199 RSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKK 1258
R S+S+P K + S + + P K R + R SP P +
Sbjct: 739 RRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSP-------CPKQKSQ 791
Query: 1259 VPSDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGS 1310
P + R G S P+ RT RRS + +QK ++ S+ H S
Sbjct: 792 TPPRRSRSGSSQPKAKSRT----PPRRSRSSSSPP-PKQKSKTPSRQSHSSS 838
Score = 41.2 bits (95), Expect = 0.007
Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 1075 KSRSKSERPPTILMTEEPSSP--KGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPD-- 1130
+ RS+S P +P +G RS R +++ G S +TP
Sbjct: 666 RGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHS----RTPQRR 721
Query: 1131 ----SFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEK 1186
S E + + RS S SSP+ ++ + S L+ ++K ++R L
Sbjct: 722 GRSGSSSERKNKSRTSQRRSRSNSSPEM-KKSRISSRRSRSLSSPRSKAKSRLSLRRSLS 780
Query: 1187 NTKAEPKAEAGSRSRSSSSTPTSPKPLLQSP--KPSLAARPVIPQKPRTASRPDDIPDSP 1244
+ PK ++ + R S S + PK ++P + ++ P QK +T SR SP
Sbjct: 781 GSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSP 840
Query: 1245 SSPKVALLPPVLKKVPSDKERDGQSSPQ--------PSPRTFSQEVSRRS 1286
+ PP + S + + +PQ P P S+ SR S
Sbjct: 841 HPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHS 890
Score = 41.2 bits (95), Expect = 0.007
Identities = 36/137 (26%), Positives = 58/137 (42%), Gaps = 20/137 (14%)
Query: 1187 NTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIP----D 1242
++ + + + S S SSSS+ +S P P P +P P+KP R P D
Sbjct: 2624 SSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPID 2683
Query: 1243 SPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPR----TFSQEVSRRSWGQQAQEYQEQK 1298
S + PV ++ P SPQPSPR + S+ SRR ++ ++
Sbjct: 2684 SLRDSRSLSYSPVERRRP---------SPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKR 2734
Query: 1299 QRSSSKD---GHQGSKS 1312
+R + H+ S+S
Sbjct: 2735 RRETPSPRPMRHRSSRS 2751
Score = 40.8 bits (94), Expect = 0.009
Identities = 66/290 (22%), Positives = 100/290 (34%), Gaps = 23/290 (7%)
Query: 1031 TKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTILMTE 1090
T K K KK R SES + K+ +S +S+ + R PT ++
Sbjct: 184 TPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSES-----ESKKRKHRSPTP-KSK 237
Query: 1091 EPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKS 1150
S K RS P ++ A + +++ T S S + +
Sbjct: 238 RKSKDKKRKRSRSTT-PAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSP 296
Query: 1151 SPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNTK--AEPKAEAGSRSRSSSSTPT 1208
SP +GRR G G + + +PE TK + P + + S+T
Sbjct: 297 SPASGRR------GEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRP 350
Query: 1209 SPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQ 1268
SP P S P A P R P + +P S + PV PS+
Sbjct: 351 SPSPERSSTGPEPPA-PTPLLAERHGGSPQPLATTPLSQE-----PV--NPPSEASPTRD 402
Query: 1269 SSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKSNDSGEE 1318
SP SP Q S S Q + + SSS + + + + S E
Sbjct: 403 RSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHRE 452
Score = 40.4 bits (93), Expect = 0.011
Identities = 64/265 (24%), Positives = 93/265 (35%), Gaps = 26/265 (9%)
Query: 1065 RKSSGFLNLIKSRSKSERPPTILMTEE----PSSPKGAVRS-----PPVDCPRKDTKAAE 1115
R S L+ +SR+ P MT E PSS G S P D PR +A
Sbjct: 2396 RTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSA- 2454
Query: 1116 HNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQ 1175
+ S + TP + SQ G V + S + G + V G+ +
Sbjct: 2455 FSDQSRCLIAQTTPVA--GSQSLSSGAVATTTSSAGDHNGM---LSVPAPGVPHSDVGEP 2509
Query: 1176 ENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTAS 1235
G P +P E S S SSSS+ +S S S + ++S
Sbjct: 2510 PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSG---------SSS 2560
Query: 1236 RPDDIPDSPSSPKVALLP-PVLKKVPSDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEY 1294
+ P P+VAL P P + R+G+ P+P+P + S S +
Sbjct: 2561 SDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRP-PEPTPAKRKRRSSSSSSSSSSSSS 2619
Query: 1295 QEQKQRSSSKDGHQGSKSNDSGEEA 1319
SSS S S+ S +
Sbjct: 2620 SSSSSSSSSSSSSSSSSSSSSSSSS 2644
Score = 40.0 bits (92), Expect = 0.015
Identities = 67/363 (18%), Positives = 125/363 (34%), Gaps = 69/363 (19%)
Query: 972 SELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANIVSQDGEQNGLMGRVDEGVDEFFT 1031
S P+ + T R R++ + P + + ++V + GR +
Sbjct: 671 SRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRR--------GRSHSRTPQRRG 722
Query: 1032 KKVTKMDSKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTILMTEE 1091
+ + + K S N + KK R S + S L+ +S++KS ++
Sbjct: 723 RSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGS 782
Query: 1092 PSSPKGAVRSPP------VDCPRKDTKAAEHNGNSERI----EEIKTPDSFEESQGEEIG 1141
PK ++PP P+ ++ S ++ KTP S
Sbjct: 783 SPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHP 842
Query: 1142 KVE-----RSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNT---KAEPK 1193
KV+ R S +SPQA + S + + ++R TP +++ + P+
Sbjct: 843 KVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSR----TPSRHSCSGSSPPR 898
Query: 1194 AEAGSRSRSSSSTPTSPKPLLQ--------------SPKPSLAARPVIPQKPRTAS---- 1235
++ + R S S +SP+P ++ SP PS P++ R+ S
Sbjct: 899 VKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSN 958
Query: 1236 ---------------------RPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPS 1274
+P+ P S ++ P V + P G SP P
Sbjct: 959 VESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQ 1018
Query: 1275 PRT 1277
++
Sbjct: 1019 EKS 1021
Score = 33.1 bits (74), Expect = 1.8
Identities = 46/214 (21%), Positives = 71/214 (33%), Gaps = 34/214 (15%)
Query: 1075 KSRSKSERPPTILMTEEPSSP----KGAVRSPPVDCPRKDTKAAEHNGNSERIEEIKTPD 1130
+ RS+S PP +P + R+PPV R ++ R
Sbjct: 1920 RRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITR 1979
Query: 1131 SFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGTPEKNTKA 1190
S+ + + RS S++SP RR + +P ++
Sbjct: 1980 RRSRSRTSPVTR-RRSRSRTSPVTRRRSRSRT--------------------SPVTRRRS 2018
Query: 1191 EPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVA 1250
+ R RS S TP P+ +S P R + PRTA + SP
Sbjct: 2019 RSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSP------ 2072
Query: 1251 LLPPVLKKVPSDKERDGQSSPQPSPRTFSQEVSR 1284
P + ++ S D S P P T + SR
Sbjct: 2073 --PAIRRRSASGSSSDRSRSATP-PATRNHSGSR 2103
>gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]
Length = 501
Score = 48.5 bits (114), Expect = 4e-05
Identities = 43/127 (33%), Positives = 62/127 (48%), Gaps = 7/127 (5%)
Query: 246 NRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK 305
+RL L L N +R AQ LA ALAHN N L ++NL N +ED G +L+ + K
Sbjct: 334 SRLRVLNLANNQVRAPGAQSLAHALAHNTN--LISLNLRLNCIEDEGGQALA-HALQTNK 390
Query: 306 GLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPN 365
L L+L LS LSQ L+ N +TL ++LS N + D + ++
Sbjct: 391 CLTTLHLGGNELSEPTATLLSQVLAIN----TTLTSINLSCNHIGLDGGKQLLEGMSDNK 446
Query: 366 AIVHLDL 372
++ DL
Sbjct: 447 TLLEFDL 453
Score = 40.8 bits (94), Expect = 0.009
Identities = 23/79 (29%), Positives = 41/79 (51%)
Query: 563 IINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVA 622
+ +AL +N LT + + GN + + A +L++ L INT L ++ N+I G + +
Sbjct: 382 LAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEG 441
Query: 623 MEKNYTLRFMPIPMYDASQ 641
M N TL + + D +Q
Sbjct: 442 MSDNKTLLEFDLRLSDVAQ 460
Score = 35.8 bits (81), Expect = 0.28
Identities = 36/144 (25%), Positives = 60/144 (41%), Gaps = 35/144 (24%)
Query: 459 LDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVW-LSKNRSIQHLALG 517
L+L+N ++R+ GAQ L +A N+ SL++ N +E + + L N+ + L LG
Sbjct: 339 LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLG 398
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEVTIIINALGSNTSLTKVD 577
N LS + T++ L NT+LT ++
Sbjct: 399 GN----------------------------ELS------EPTATLLSQVLAINTTLTSIN 424
Query: 578 ISGNGMGDMGAKMLAKALQINTKL 601
+S N +G G K L + + N L
Sbjct: 425 LSCNHIGLDGGKQLLEGMSDNKTL 448
Score = 33.5 bits (75), Expect = 1.4
Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 1/87 (1%)
Query: 544 SPLQSLSLADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLR 602
S L+ L+LA+++++ + +AL NT+L +++ N + D G + LA ALQ N L
Sbjct: 334 SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLT 393
Query: 603 TVIWDKNNITAQGFQDIAVAMEKNYTL 629
T+ N ++ ++ + N TL
Sbjct: 394 TLHLGGNELSEPTATLLSQVLAINTTL 420
Score = 33.1 bits (74), Expect = 1.8
Identities = 29/118 (24%), Positives = 56/118 (47%), Gaps = 11/118 (9%)
Query: 539 IQDEESPLQSLSLADSKLKTEVTIIINALG-----------SNTSLTKVDISGNGMGDMG 587
+ D+++ + SL D + E+ + N +G S++ L ++++ N + G
Sbjct: 291 VDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPG 350
Query: 588 AKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDASQALKT 645
A+ LA AL NT L ++ N I +G Q +A A++ N L + + + S+ T
Sbjct: 351 AQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTAT 408
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 47.4 bits (111), Expect = 9e-05
Identities = 52/213 (24%), Positives = 86/213 (40%), Gaps = 22/213 (10%)
Query: 1114 AEHNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLLAEMKA 1173
++H+ +R+ + P F+ + +I V++SDS S GS LA+
Sbjct: 967 SKHSAQGDRLPPLSGP--FDNNN--QIAYVDQSDSVDSSPVKEVKAPSHPGS--LAKKPE 1020
Query: 1174 KQENRF----GLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQ 1229
R G PEK+ + A A S SS++P+SP P+ S KPS +
Sbjct: 1021 STTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSR-----S 1075
Query: 1230 KPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPRTFSQEVSRRSWGQ 1289
K ++SR SP+ P KK S K +D SSP P + + ++ +
Sbjct: 1076 KADSSSRGSGRHSSPA-------PAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASST 1128
Query: 1290 QAQEYQEQKQRSSSKDGHQGSKSNDSGEEAEKE 1322
A++ RS G + + E ++
Sbjct: 1129 SAKKASGPATRSPFPPGKSRTSDHSLSREGSRQ 1161
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 93/415 (22%), Positives = 154/415 (37%), Gaps = 85/415 (20%)
Query: 253 LENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPK-GLKHLN 311
L++ GL + ++SAL NP L +NL N L D GV + +Q + P ++ L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNP--ALAELNLRSNELGDVGVHCV-LQGLQTPSCKIQKLS 91
Query: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371
L L+ G LS +L P TL L LS N+L L + L P
Sbjct: 92 LQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQLLCEGLLDP------- 140
Query: 372 LSNTECSLDMV----CGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427
+C L+ + C C +VL P FK+ S+
Sbjct: 141 ----QCRLEKLQLEYCSLSAASCEPLASVLRAK-------------PDFKELTVSN---N 180
Query: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSL 487
IN +G ++ + LK L +L L +C + S + L G +A ++ L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLE--------ALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 488 DISDNGL---------------ESDLSTLIVW---------------LSKNRSIQHLALG 517
+ N L S L TL +W L S++ L+L
Sbjct: 233 ALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLA 292
Query: 518 KNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLKTEV-TIIINALGSNTSLTKV 576
N + L L + + + L+SL + + + L N L ++
Sbjct: 293 GNELGDEGARL------LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 577 DISGNGMGDMGAKMLAKALQINTKLRTVIWDKN-NITAQGFQDIAVAMEKNYTLR 630
IS N + D G + L + L + V+W + +++ +A + N++LR
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Score = 47.0 bits (110), Expect = 1e-04
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 226 KDLKLST-DVCEQILRVVSRSNR-----LEELVLENAGLRTDFAQKLASALAHNPNSGLH 279
K+L +S D+ E +RV+ + + LE L LE+ G+ +D + L +A + L
Sbjct: 173 KELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK--ASLR 230
Query: 280 TINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTL 339
+ L N L D G++ L L+ L + + ++ KG L + L A +L
Sbjct: 231 ELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK----ESL 286
Query: 340 VHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDMVCGALLRGCLQYLAVLNL 399
L L+GN L + + L +P + L CS C C + +VL
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLE-SLWVKSCSFTAAC------CSHFSSVLAQ 339
Query: 400 SRTVFSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSL 459
+R L+ + +S +L ++ L GL ++ V L
Sbjct: 340 NRF-----------------------LLELQISNNRLEDAGVRELCQGLGQPGSVLRV-L 375
Query: 460 DLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL 494
L++C++ L + H++ LD+S+N L
Sbjct: 376 WLADCDVSDSSCSSLAATLLANHSLRELDLSNNCL 410
Score = 39.3 bits (90), Expect = 0.025
Identities = 63/289 (21%), Positives = 105/289 (36%), Gaps = 39/289 (13%)
Query: 247 RLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKG 306
RLE+L LE L + LAS L P+ + ++ N + + GV L P
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPD--FKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 307 LKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNA 366
L+ L L ++ L +++ ++L L L N L ++ + L P+
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASK----ASLRELALGSNKLGDVGMAELCPGLLHPS- 255
Query: 367 IVHLDLSNTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLAL 426
S CG +GC VL ++ KE+ + + L
Sbjct: 256 ------SRLRTLWIWECGITAKGCGDLCRVLRAKESL------KELSLAGNELGDEGARL 303
Query: 427 MHINL--SGTKLSPEPLKALLLGLACNHNLKGV--------SLDLSNCELRSGGAQVL-- 474
+ L G +L +K+ AC + V L +SN L G + L
Sbjct: 304 LCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQ 363
Query: 475 ----EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN 519
G + + + D+SD+ S +TL+ N S++ L L N
Sbjct: 364 GLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA----NHSLRELDLSNN 408
Score = 37.7 bits (86), Expect = 0.074
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 234 VCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGV 293
+CE +L +LE L +++ +S LA N L + ++ N LED GV
Sbjct: 304 LCETLLEP---GCQLESLWVKSCSFTAACCSHFSSVLAQN--RFLLELQISNNRLEDAGV 358
Query: 294 SSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDD 353
L + L+ L L+ +S +SL+ +L AN +L LDLS N L
Sbjct: 359 RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLAN----HSLRELDLSNNCLGDAG 414
Query: 354 LSHMYNFLAQPNAIV 368
+ + + QP ++
Sbjct: 415 ILQLVESVRQPGCLL 429
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 47.0 bits (110), Expect = 1e-04
Identities = 62/242 (25%), Positives = 108/242 (44%), Gaps = 18/242 (7%)
Query: 439 EPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDL 498
EP +A+L L H L LDL+ L + L + T L +SD L +
Sbjct: 18 EPQEAVLQQL---HQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEG 74
Query: 499 STLIV-WLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEESPLQSLSLADSKLK 557
+TL++ L N ++ L L NN+++ + L +++Q +S +QSL+L + L
Sbjct: 75 ATLLLRGLCANTVLRFLDL--KGNNLRAAGA----EALGKLLQQNKS-IQSLTLEWNSLG 127
Query: 558 T---EVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQ 614
T L +N +L ++D+ N + GA+ LA AL+ NT L+ + NN+
Sbjct: 128 TWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLL 187
Query: 615 GFQDIAVAMEKNYTLRFMPIP----MYDASQALKTNPEKTEDALQKIENYLLRNHETRKY 670
G + + + N TL + + D +A++ ++D L + R H K
Sbjct: 188 GGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKE 247
Query: 671 LQ 672
+Q
Sbjct: 248 VQ 249
Score = 33.9 bits (76), Expect = 1.1
Identities = 41/182 (22%), Positives = 72/182 (39%), Gaps = 35/182 (19%)
Query: 230 LSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPL- 288
L+ + C + +++ R ELVL + L + A L L N+ L ++L GN L
Sbjct: 42 LTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLC--ANTVLRFLDLKGNNLR 99
Query: 289 ------------EDRGVSSLSIQFAKLPK----------------GLKHLNLSKTSLSPK 320
+++ + SL++++ L L+ L+L +S K
Sbjct: 100 AAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHK 159
Query: 321 GVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLD 380
G L+ +L N +TL LDL N + + N L + LDL+ D
Sbjct: 160 GAEELALALKGN----TTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGD 215
Query: 381 MV 382
++
Sbjct: 216 VL 217
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 46.6 bits (109), Expect = 2e-04
Identities = 40/148 (27%), Positives = 69/148 (46%), Gaps = 12/148 (8%)
Query: 221 TKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHT 280
T LS D++ +CE + + + +EEL+L + ++ + +AS LA NS L
Sbjct: 695 TSLSQSDIR---HLCETLKHPMCK---IEELILGKCDISSEVCEDIASVLA--CNSKLKH 746
Query: 281 INLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLV 340
++L NPL D G++ L L+ L L L+ +S+S+ L L + +L
Sbjct: 747 LSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL----LCSKSLS 802
Query: 341 HLDLSGNVLRGDDLSHMYNFLAQPNAIV 368
LDL N L + ++ + L P +
Sbjct: 803 LLDLGSNALEDNGVASLCAALKHPGCSI 830
Score = 30.8 bits (68), Expect = 9.0
Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 3/117 (2%)
Query: 230 LSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLE 289
L++D C+ I V+ + +L+ L L + + ++L +AL H P+ L + L P+
Sbjct: 840 LTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQH-PHCKLECLGLQTCPIT 898
Query: 290 DRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSG 346
++ K L+ LNL +L V L ++LS +P A ++ L SG
Sbjct: 899 RACCDDIAAALIAC-KTLRSLNLDWIALDADAVVVLCEALS-HPDCALQMLGLHKSG 953
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 45.1 bits (105), Expect = 5e-04
Identities = 72/337 (21%), Positives = 123/337 (36%), Gaps = 33/337 (9%)
Query: 893 RSIITVEELTEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIH 952
R I VE+ R +S+ +S HSR R S + + ++
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSR 227
Query: 953 IEDPPFPSLRQEKRSSGFISELPSEEGKKLEHFTKLRPKRNKKQQPTQAAVCAANI---- 1008
+ RS S PS+E + + + + K Q + N+
Sbjct: 228 SRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK 287
Query: 1009 ---VSQDGEQNGLMGRVDEG-VDEFFTKKVTKMDSKKWSTRGSESHELNEGGDEKKKRDS 1064
S+ ++ R E V+E V++ S++ S R S S ++GG + R
Sbjct: 288 SRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSR 347
Query: 1065 RKSSGFLNLIKSRSKSERPPTILMTEEPSSPKGAVRSPPVDCPRKDTKAAEHNGNSERIE 1124
KS K + K + + E S + RS ++ +K G+S++ +
Sbjct: 348 SKS-------KDKRKGRK-----RSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKK 395
Query: 1125 EIKTPDSFEESQGEEIGKV-ERSDSKSSPQAGRRYGVQVMGSGLLAEMKAKQENRFGLGT 1183
+ T S S + K E + S+SS + GR G QE R
Sbjct: 396 KEDTDRSQSRSPSRSVSKEREHAKSESSQREGR---------GESENAGTNQETR---SR 443
Query: 1184 PEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPS 1220
N+K++P + SRSRS S++ T + +S S
Sbjct: 444 SRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSAS 480
Score = 37.0 bits (84), Expect = 0.13
Identities = 55/266 (20%), Positives = 93/266 (34%), Gaps = 14/266 (5%)
Query: 1039 SKKWSTRGSESHELNEGGDEKKKRDSRKSSGFLNLIKSRSKSERPPTILMTEEPSSPKGA 1098
SK S S S E K SR S +S+SK + I + PK
Sbjct: 230 SKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKS- 288
Query: 1099 VRSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRY 1158
RSP R +K+ + + ER E + S + +E + +S S+S + G R
Sbjct: 289 -RSP----SRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQE-KSLRQSRSRSRSKGGSR- 341
Query: 1159 GVQVMGSGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPK 1218
S + K+K + + + E++ RSR S S + K
Sbjct: 342 ------SRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKK 395
Query: 1219 PSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPRTF 1278
R R+ S+ + S SS + + +S+ + P
Sbjct: 396 KEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLP 455
Query: 1279 SQEVSRRSWGQQAQEYQEQKQRSSSK 1304
S+ SR + + + + RS+S+
Sbjct: 456 SESRSRSKSASKTRSRSKSRSRSASR 481
Score = 33.5 bits (75), Expect = 1.4
Identities = 47/210 (22%), Positives = 85/210 (40%), Gaps = 22/210 (10%)
Query: 1111 TKAAEHNG--NSERIEEIKTPD---SFEESQGEEIG--KVERSDSKSSPQAGRRYGVQVM 1163
T A H G N IE + D + E+ G E+ K+ + K + R Y
Sbjct: 131 TYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRS 190
Query: 1164 GSGLLAEMKAKQENRFGLGTPEKNTKAEPKAEAGSRSRSSSSTPTSPKPLLQSPKPSLAA 1223
S + + +++R G+ + + +++ SRSRS S + + + QS S
Sbjct: 191 HSRSRSRSRHSRKSRSRSGSSKSS-----HSKSRSRSRSGSRSRSKSRSRSQSRSRSKKE 245
Query: 1224 RPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERDGQSSPQPSPRTFSQEVS 1283
+ P K ++ SR S S K +K ++ + +P R+ S+ S
Sbjct: 246 KSRSPSKEKSRSRSHSAGKSRSKS---------KDQAEEKIQNNDNVGKPKSRSPSRHKS 296
Query: 1284 RRSWGQQAQEYQ-EQKQRSSSKDGHQGSKS 1312
+ ++QE + E+++R S G KS
Sbjct: 297 KSKSRSRSQERRVEEEKRGSVSRGRSQEKS 326
>gi|76563940 synuclein alpha interacting protein [Homo sapiens]
Length = 919
Score = 44.7 bits (104), Expect = 6e-04
Identities = 38/131 (29%), Positives = 58/131 (44%), Gaps = 7/131 (5%)
Query: 1193 KAEAGSRSRSSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALL 1252
KA S S T S +P L+S P + P P +P + PDS ++ KVA
Sbjct: 738 KASKSLDGHSPSPTSESSEPDLESQYPGSGSIP--PNQP-SGDPQQPSPDSTAAQKVATS 794
Query: 1253 PPVLKKVPSDKERDGQSSPQPSPRTFSQEVSRRSWGQQAQEYQEQKQRSSSKDGHQGSKS 1312
P K PS K R Q+ TF + V + Q + E +K + + + S S
Sbjct: 795 PKSALKSPSSKRRTSQNLKLRV--TFEEPVVQME--QPSLELNGEKDKDKGRTLQRTSTS 850
Query: 1313 NDSGEEAEKEF 1323
N+SG++ ++ F
Sbjct: 851 NESGDQLKRPF 861
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,533,699
Number of Sequences: 37866
Number of extensions: 2351964
Number of successful extensions: 12019
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 655
Number of HSP's that attempted gapping in prelim test: 10067
Number of HSP's gapped (non-prelim): 2244
length of query: 1326
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1212
effective length of database: 13,930,794
effective search space: 16884122328
effective search space used: 16884122328
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.