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Search of human proteins with 62988340
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62988340 leucine rich repeat containing 22 [Homo sapiens]
(550 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62988340 leucine rich repeat containing 22 [Homo sapiens] 1122 0.0
gi|193083136 leucine-rich repeat, immunoglobulin-like and transm... 191 2e-48
gi|14149694 retina specific protein PAL [Homo sapiens] 190 3e-48
gi|27363458 leucine rich repeat and fibronectin type III domain ... 113 5e-25
gi|31542244 leucine rich repeat and fibronectin type III domain ... 104 2e-22
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 97 4e-20
gi|13375646 leucine rich repeat and fibronectin type III domain ... 97 4e-20
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 97 4e-20
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 96 9e-20
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 94 3e-19
gi|149773484 leucine rich repeat and fibronectin type III domain... 94 4e-19
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 94 4e-19
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 94 4e-19
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 94 4e-19
gi|194306623 immunoglobulin superfamily containing leucine-rich ... 92 1e-18
gi|194306621 immunoglobulin superfamily containing leucine-rich ... 92 1e-18
gi|39930401 immunoglobulin superfamily containing leucine-rich r... 92 1e-18
gi|194306618 immunoglobulin superfamily containing leucine-rich ... 92 1e-18
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 89 1e-17
gi|4759146 slit homolog 2 [Homo sapiens] 86 7e-17
gi|109150416 peroxidasin [Homo sapiens] 86 9e-17
gi|11321571 slit homolog 3 [Homo sapiens] 86 9e-17
gi|188528675 slit homolog 1 [Homo sapiens] 84 3e-16
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 84 3e-16
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 84 3e-16
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 82 1e-15
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 82 1e-15
gi|55741571 leucine rich repeat and fibronectin type III domain ... 81 3e-15
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 80 4e-15
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 80 5e-15
>gi|62988340 leucine rich repeat containing 22 [Homo sapiens]
Length = 550
Score = 1122 bits (2901), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 1 MASVFHYFLLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQV 60
MASVFHYFLLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQV
Sbjct: 1 MASVFHYFLLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQV 60
Query: 61 RIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPW 120
RIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPW
Sbjct: 61 RIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPW 120
Query: 121 TAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKC 180
TAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKC
Sbjct: 121 TAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKC 180
Query: 181 RQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQ 240
RQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQ
Sbjct: 181 RQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQ 240
Query: 241 LFHETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLT 300
LFHETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLT
Sbjct: 241 LFHETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLT 300
Query: 301 SSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPS 360
SSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPS
Sbjct: 301 SSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPS 360
Query: 361 EGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGINTYAV 420
EGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGINTYAV
Sbjct: 361 EGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGINTYAV 420
Query: 421 DDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVVLLAVPVG 480
DDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVVLLAVPVG
Sbjct: 421 DDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVVLLAVPVG 480
Query: 481 AYAWAAQGPCSCSKWVLRGCLHRRKAPSCTPAAPQSKDGSFREHPAVCDDGEGHIDTEGD 540
AYAWAAQGPCSCSKWVLRGCLHRRKAPSCTPAAPQSKDGSFREHPAVCDDGEGHIDTEGD
Sbjct: 481 AYAWAAQGPCSCSKWVLRGCLHRRKAPSCTPAAPQSKDGSFREHPAVCDDGEGHIDTEGD 540
Query: 541 KEKGGTEDNS 550
KEKGGTEDNS
Sbjct: 541 KEKGGTEDNS 550
>gi|193083136 leucine-rich repeat, immunoglobulin-like and
transmembrane domains 3 [Homo sapiens]
Length = 634
Score = 191 bits (484), Expect = 2e-48
Identities = 101/302 (33%), Positives = 161/302 (53%), Gaps = 3/302 (0%)
Query: 44 VSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLP 103
+ + ++P NL + ++RIE + + + +F + L+YLW+ +N+++ I + +L
Sbjct: 1 MDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLK 60
Query: 104 ELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRL 163
+L ELRL+GN L + PW + PLLR LDL NKI ++P AL++L +L YLDLSSNRL
Sbjct: 61 QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
Query: 164 TVVSKSVFLNWPAYQKCRQPDCGAEIL-SSLVVALHDNPWVCDCRLRGLVQFVKSITLPV 222
T + +W P ++ S +++ L DNPW CDC + +++ K + +
Sbjct: 121 TTLPPDFLESWT--HLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAI 178
Query: 223 ILVNSYLICQGPLSKAGQLFHETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSP 282
+L++ + C P G LF EL C+KP + T + I G NV LRC A P+P
Sbjct: 179 VLLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTP 238
Query: 283 SIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISL 342
I WT S + V+ S E S +++ D+G+Y C A N G S V+++
Sbjct: 239 QITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTV 298
Query: 343 HV 344
V
Sbjct: 299 TV 300
Score = 55.5 bits (132), Expect = 1e-07
Identities = 40/119 (33%), Positives = 57/119 (47%), Gaps = 6/119 (5%)
Query: 360 SEGNAYID-LRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGI--N 416
+E NA I+ LRVV +T + L W + T LY + K+++ + N
Sbjct: 436 TETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLY---SKYGGKDLLLLNADSSKN 492
Query: 417 TYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVVLL 475
+D L PG +Y AC+ +G PP + QC+ F T R G LL VT CVV+L
Sbjct: 493 QVTIDGLEPGGQYMACVCPKGVPPQKDQCITFSTERVEGDDSQWSLLLVVTSTACVVIL 551
>gi|14149694 retina specific protein PAL [Homo sapiens]
Length = 623
Score = 190 bits (482), Expect = 3e-48
Identities = 113/330 (34%), Positives = 168/330 (50%), Gaps = 8/330 (2%)
Query: 20 AQPFCLPGCTCSEESFG-----RTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGS 74
A+ FC C+CS G RT+ C + P ++ + ++R+E + + +P +
Sbjct: 19 ARGFCPSQCSCSLHIMGDGSKARTVVCNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEA 78
Query: 75 FINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDL 134
F + LE LWL +N +S ++ L L LRELRL GN+L + PW A R P LR+LDL
Sbjct: 79 FRPLGRLEQLWLPYNALSELNALMLRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDL 138
Query: 135 KRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV 194
+ N++ A+P A +FL +LT+LDLSSN+L + + + ++W + P V
Sbjct: 139 QANRLSAVPAEAARFLENLTFLDLSSNQLMRLPQELIVSWAHLETGIFPPGHH---PRRV 195
Query: 195 VALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQ 254
+ L DNPW CDCRL LV + + + + L C P S AG F + EL C P+
Sbjct: 196 LGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPE 255
Query: 255 ISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAI 314
+ A+I G LRC A P P ++W V + + T+ + L +
Sbjct: 256 LHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGL 315
Query: 315 PAAHLVDSGNYTCMASNSIGKSNLVISLHV 344
PA +DSG+Y C A N +G S VISL V
Sbjct: 316 PAVSHLDSGDYICQAKNFLGASETVISLIV 345
Score = 63.2 bits (152), Expect = 6e-10
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 2/126 (1%)
Query: 354 DSLSIPSEGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGP 413
D + PSE ++VV T H + L W A + + LY + + V+ + P
Sbjct: 420 DGRAGPSEARMVRSVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVI-VQP 478
Query: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVV 473
G + LLP TKY AC+ ++G P + QCV F T + E + L++V V+ +
Sbjct: 479 GKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFST-NEVVDAENTQQLINVVVISVAI 537
Query: 474 LLAVPV 479
++A+P+
Sbjct: 538 VIALPL 543
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 113 bits (282), Expect = 5e-25
Identities = 94/314 (29%), Positives = 138/314 (43%), Gaps = 36/314 (11%)
Query: 55 EEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEH-LPELRELRLEGN 113
E + + ++ + L E+ GS L++L L+ N + I GA + L L +L L N
Sbjct: 96 ESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYN 155
Query: 114 KLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLN 173
L VPW A P L L+L N IDALP A L L+ LDL+SNRL ++
Sbjct: 156 NLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLAPD---- 211
Query: 174 WPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQG 233
P + + R + + LV++ NP C+C L L + + L C
Sbjct: 212 -PLFSRGRDAEASP---APLVLSFSGNPLHCNCELLWLRRLARPDDLET--------CAS 259
Query: 234 PLSKAGQLF---HETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPL 290
P AG+ F E E S C P I+ + + + GQ TLRC A P+P++ W P
Sbjct: 260 PPGLAGRYFWAVPEGEFS-CEPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGP- 317
Query: 291 SMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQPAQAL 350
+ V SS L I D+G YTC+A+N G++ + L V
Sbjct: 318 ---DDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRV------ 368
Query: 351 HAPDSLSIPSEGNA 364
L++P GN+
Sbjct: 369 -----LALPHGGNS 377
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 104 bits (259), Expect = 2e-22
Identities = 100/404 (24%), Positives = 169/404 (41%), Gaps = 47/404 (11%)
Query: 58 KQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCS 117
+ + + ++ L ++ F +S L +L LN N +++I A + + L EL L N L +
Sbjct: 102 RALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLET 161
Query: 118 VPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAY 177
+PW A L L L N ID +P+ L +T LD++SN+L + P +
Sbjct: 162 IPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPD-----PLF 216
Query: 178 QKCR-QPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLS 236
Q+ + G S+ ++ NP C+C L L + + L C P
Sbjct: 217 QRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLET--------CASPPL 268
Query: 237 KAGQLFHE--TELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWR 294
G+ F E C P I+ + + + GQ TLRC A+ P P+I W P +
Sbjct: 269 LTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEG--K 326
Query: 295 EFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHV-------QPA 347
T S D ++ I + D+G +TC+ASN G++ ++ LH+
Sbjct: 327 LISNATRSLVYDNGTLDILITT--VKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNST 384
Query: 348 QALHAPD-------------SLSIPSEGNAYID---LRVVKQTVHGILLEWLAVADTSKE 391
+H PD S + S G+ + + V + T LL++ +
Sbjct: 385 NHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEATSSTALLKFNFQRNIPGI 444
Query: 392 EWFTLYIASDEAFRKEVVH--IGPGINTYAVDDLLPGTKYEACL 433
F I + + +V+ I P T+ V++L GT Y+ C+
Sbjct: 445 RMF--QIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCV 486
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 97.1 bits (240), Expect = 4e-20
Identities = 96/395 (24%), Positives = 159/395 (40%), Gaps = 66/395 (16%)
Query: 10 LVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFE 69
L+L+ L AA GC + + T++C ++ L +P + + + ++++ +
Sbjct: 11 LLLLLLPLRAA------GCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIAR 64
Query: 70 MPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLL 129
+ G+ ++ L L+L+ N++ + GA P L EL L N+L + AF L
Sbjct: 65 LEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQL 124
Query: 130 RVL------------------------DLKRNKIDALPELALQFLVSLTYLDLSSNRLTV 165
RVL L+ N I+ L + AL L SL LDLS N+L
Sbjct: 125 RVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGT 184
Query: 166 VSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILV 225
+S+ QP + S V+ L +NPW CDC L L ++K ++
Sbjct: 185 ISREAL----------QP-----LASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTS 229
Query: 226 -NSYLICQGPLSKAGQLFHETELSA--CMKPQISTPSANITIRAGQNVTLRCLAQASPSP 282
+ ++C P A Q + S+ C+ P + +T G+++ + C A P P
Sbjct: 230 RDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQP 289
Query: 283 SIAWTYPLSMWRE------------FDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMAS 330
+ W + RE L + DT L + L +G Y C AS
Sbjct: 290 LVTWR-KVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEAS 348
Query: 331 NSIGKSNLVISLHV-----QPAQALHAPDSLSIPS 360
N+ G + + L V QP Q P + P+
Sbjct: 349 NAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPA 383
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 97.1 bits (240), Expect = 4e-20
Identities = 134/613 (21%), Positives = 217/613 (35%), Gaps = 119/613 (19%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C +S ++ C L +P +L ++R+ ++ + + + NM+ L +
Sbjct: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLH 87
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCS-------------------------- 117
L L+ N I + GA L LR L L+GN+L S
Sbjct: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
Query: 118 -----------------------VPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLT 154
+PW A + L L N + ++P A L L
Sbjct: 148 AGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLA 207
Query: 155 YLDLSSNRLTVVSKS-VFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQ 213
LD++SNRLT + +F P + R S+LV+A NP C+C L L +
Sbjct: 208 RLDMTSNRLTTIPPDPLFSRLPLLARPR-----GSPASALVLAFGGNPLHCNCELVWLRR 262
Query: 214 FVKSITLPVILVNSYLICQGPLSKAGQLFHET--ELSACMKPQISTPSANITIRAGQNVT 271
+ L C P + G+ F E C P ++ S + + AG+
Sbjct: 263 LAREDDLEA--------CASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAA 314
Query: 272 LRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASN 331
LRC A P P + W P + SS L + D G +TC+A+N
Sbjct: 315 LRCRAVGDPEPRVRWVSPQGRL----LGNSSRARAFPNGTLELLVTEPGDGGIFTCIAAN 370
Query: 332 SIGKSNLVISLHV---QPAQALHA----------PDSLSIPSEGNAYIDL--------RV 370
+ G++ + L V P Q ++ PD+L+ PS +A + R
Sbjct: 371 AAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKVADTGPPTDRG 430
Query: 371 VKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVV---HIGPGINTYAVDDLLPGT 427
V+ T HG + D +Y + +++ I ++ + DL G
Sbjct: 431 VQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRSFLLTDLASGR 490
Query: 428 KYEACLSLEGQPPHQG-------QCVAFVTG---RDAGG----------LEAREHLLHVT 467
Y+ C+ + G C F T R G + A ++ +
Sbjct: 491 TYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALGGVIVAS 550
Query: 468 VVLCVVLLAVPVGAYAWAAQGPCSCSKWVLRGCLHRRKA--PSCTPAAPQSKDGSFREHP 525
V++ + +L + + G V C A P+ TPA P + + R H
Sbjct: 551 VLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPAPEPAALRAHT 610
Query: 526 AVCDD----GEGH 534
V D G GH
Sbjct: 611 VVQLDCEPWGPGH 623
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 97.1 bits (240), Expect = 4e-20
Identities = 89/311 (28%), Positives = 127/311 (40%), Gaps = 37/311 (11%)
Query: 48 KIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRE 107
++PG L E I+N PL E + L L + NI+ + AL H L
Sbjct: 220 RLPGLLHLE-----IDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTC 274
Query: 108 LRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVS 167
L L N + +VP +FR LR L L + + A L + L+LS+N L+ +
Sbjct: 275 LNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLE 334
Query: 168 KSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNS 227
+S F + + R + NP CDCRL +VQ K++ L
Sbjct: 335 ESTFHSVNTLETLR---------------VDGNPLACDCRLLWIVQRRKTLNFDGRLP-- 377
Query: 228 YLICQGPLSKAGQLFHET------ELSACMKPQI-STPSANITIRAGQNVTLRCLAQASP 280
C P G E C KP+I +T AG++V C A+ P
Sbjct: 378 --ACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEP 435
Query: 281 SPSIAWTYPLSMWREFDVLTSSTGEDTAL--SELAIPAAHLVDSGNYTCMASNSIGKSNL 338
+P++AW P + V +S G L L I A DSG YTC+ASN+ G
Sbjct: 436 APTVAWVTP----QHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTY 491
Query: 339 VISLHVQPAQA 349
+L V+P A
Sbjct: 492 FATLTVRPEPA 502
Score = 73.9 bits (180), Expect = 3e-13
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 2/168 (1%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C+ ++ R + CT L +P + E + + + + + + G + LE
Sbjct: 25 CPARCECTVQT--RAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEE 82
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
L L+ N I+ + GA +LP LR LRL GN+L +P F L +LDL NK+ L
Sbjct: 83 LDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILL 142
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILS 191
+ Q L SL L++ N L VS+ F A ++ C LS
Sbjct: 143 DYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALS 190
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 95.9 bits (237), Expect = 9e-20
Identities = 105/429 (24%), Positives = 178/429 (41%), Gaps = 47/429 (10%)
Query: 37 RTLQCTSVSLGKIPGNLS---EEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISV 93
R+L + L IPGN + + + ++ L ++PQ + + L++L LN N I
Sbjct: 218 RSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHK 277
Query: 94 IHLGALEHLPELRELRLEG-NKLCSVPWTAFRATPLLRVLDLKRN-KIDALPELALQFLV 151
I G +++ L+EL + +L SV A P L L+ N K+ + LA + +
Sbjct: 278 IQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVP 337
Query: 152 SLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSL-VVALHDNPWVCDCRLRG 210
+L L L++N L + YQK E L +L +++H NP CDC +
Sbjct: 338 ALESLMLNNNALNAI----------YQKT------VESLPNLREISIHSNPLRCDCVIHW 381
Query: 211 L------VQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQISTPSANITI 264
+ ++F++ +++ + Y +G K + +E M S P+ + +
Sbjct: 382 INSNKTNIRFMEPLSMFCAMPPEY---KGHQVKEVLIQDSSEQCLPMISHDSFPN-RLNV 437
Query: 265 RAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGN 324
G V L C A A P P I W P+ + L S + ++ L I + DSG
Sbjct: 438 DIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETL-SDKYKLSSEGTLEISNIQIEDSGR 496
Query: 325 YTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLRVVKQTVHGILLEWLA 384
YTC+A N G V ++ V +G + + V + H IL+ W
Sbjct: 497 YTCVAQNVQGADTRVATIKVNGTLL-----------DGTQVLKIYVKQTESHSILVSWKV 545
Query: 385 VAD--TSKEEWFTLYIASDEAFRKEVVHIGPGINTYAVDDLLPGTKYEACLSLEG-QPPH 441
++ TS +W + + D + ++ Y + L P T YE CL++
Sbjct: 546 NSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQT 605
Query: 442 QGQCVAFVT 450
Q CV T
Sbjct: 606 QKSCVNVTT 614
Score = 51.2 bits (121), Expect = 2e-06
Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 8/157 (5%)
Query: 21 QPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQG--SFINM 78
+P+ P T E + T+ C + L +IP NLS + + + ++++ + + N+
Sbjct: 41 RPWFTPQSTYREAT---TVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNL 97
Query: 79 STLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNK 138
+ L++ NF NI + L +L +L L LE N++ + + L+ L + N+
Sbjct: 98 TELDFSQNNFTNIKEV---GLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQ 154
Query: 139 IDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWP 175
I + A L +L L L+SN+L V+ F + P
Sbjct: 155 ISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTP 191
Score = 46.6 bits (109), Expect = 6e-05
Identities = 31/105 (29%), Positives = 51/105 (48%)
Query: 60 VRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVP 119
+ +E + + EM ++S L+ L++N N IS I A L L L L NKL +
Sbjct: 124 LHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVID 183
Query: 120 WTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLT 164
F +TP L +L + N + + ++ + L +L L L+ LT
Sbjct: 184 SRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLT 228
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/151 (25%), Positives = 67/151 (44%), Gaps = 2/151 (1%)
Query: 23 FCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLE 82
+CL + +E + Q +++S G + ++ + ++ L + F + LE
Sbjct: 137 YCLQDLSNLQELYINHNQISTISAHAFAG--LKNLLRLHLNSNKLKVIDSRWFDSTPNLE 194
Query: 83 YLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDAL 142
L + N + I + L LR L L G L +P A L L NK+ +
Sbjct: 195 ILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKV 254
Query: 143 PELALQFLVSLTYLDLSSNRLTVVSKSVFLN 173
P+LALQ + +L +LDL+ N + + + F N
Sbjct: 255 PQLALQKVPNLKFLDLNKNPIHKIQEGDFKN 285
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 94.0 bits (232), Expect = 3e-19
Identities = 82/297 (27%), Positives = 130/297 (43%), Gaps = 32/297 (10%)
Query: 58 KQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCS 117
K + I+ PL +M + + L L + N+S + A +HL L L L N + +
Sbjct: 228 KHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIST 287
Query: 118 VPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAY 177
+ F L+ L + ++ + + Q L L L++S N L + ++VF + A
Sbjct: 288 IEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRAL 347
Query: 178 QKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGP--- 234
+ V+++++NP CDCRL ++Q ++ +C GP
Sbjct: 348 E---------------VLSINNNPLACDCRLLWILQRQPTLQFG----GQQPMCAGPDTI 388
Query: 235 LSKAGQLFHETELS---ACMKPQISTPSA-NITIRAGQNVTLRCLAQASPSPSIAWTYPL 290
++ + FH T LS C KP+I ++ + GQ V L C A P P I+W P
Sbjct: 389 RERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTP- 447
Query: 291 SMWREFDVLTSSTGEDTALSE--LAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQ 345
R + T S G T L + L I A DSG Y C+ASN+ G SL V+
Sbjct: 448 ---RRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVK 501
Score = 69.3 bits (168), Expect = 9e-12
Identities = 59/196 (30%), Positives = 91/196 (46%), Gaps = 12/196 (6%)
Query: 10 LVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFE 69
+VL+F+ + C C CS ++ +++ C L IP + E K + + + L
Sbjct: 17 VVLIFMGSTIG---CPARCECSAQN--KSVSCHRRRLIAIPEGIPIETKILDLSKNRLKS 71
Query: 70 MPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLL 129
+ FI+ LE + L+ N I+ + GA +L LR LRL+GN+L VP F L
Sbjct: 72 VNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNL 131
Query: 130 RVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF-----LNWPAYQKCRQPD 184
LD+ NKI L + Q L +L L++ N L +S F L +KC
Sbjct: 132 TKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTA 191
Query: 185 CGAEILSSL--VVALH 198
E LS L +++LH
Sbjct: 192 VPTEALSHLRSLISLH 207
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 93.6 bits (231), Expect = 4e-19
Identities = 123/541 (22%), Positives = 190/541 (35%), Gaps = 99/541 (18%)
Query: 10 LVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFE 69
L+L++ QP C C C + T+ C L +P + ++R+ ++ +
Sbjct: 21 LLLLWAGASRGQP-CPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAA 79
Query: 70 MPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSV----------- 118
+ + F NM++L +L L+ N I + GA L LR L L+ N+L V
Sbjct: 80 VRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNL 139
Query: 119 --------------------------------------PWTAFRATPLLRVLDLKRNKID 140
PW A L L L N ID
Sbjct: 140 RHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
Query: 141 ALPELALQFLVSLTYLDLSSNRL-TVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHD 199
+ E L L LD++SNRL + +FL R G + + L V+
Sbjct: 200 HIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFL--------RSQGTGPKPPTPLTVSFGG 251
Query: 200 NPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHE--TELSACMKPQIST 257
NP C+C L L + + L C P + F E C P I+
Sbjct: 252 NPLHCNCELLWLRRLTREDDLET--------CATPEHLTDRYFWSIPEEEFLCEPPLITR 303
Query: 258 PS-ANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPA 316
+ + GQ V+LRC A P P + W P T G+ T L +
Sbjct: 304 QAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGT----LDVTI 359
Query: 317 AHLVDSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIP----------------- 359
L DSG +TC+ASN+ G++ + + V P + P + P
Sbjct: 360 TTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGA 419
Query: 360 SEGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGINTYA 419
++ A L + T + +L+ W A + + S I T+
Sbjct: 420 NDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFL 479
Query: 420 VDDLLPGTKYEACLSL---EGQPPHQGQ----CVAFVTGRD-AGGLEAREHLLHVTVVLC 471
V+DL G Y+ C+ +G CV F T D A R H L T+++
Sbjct: 480 VNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIA 539
Query: 472 V 472
+
Sbjct: 540 I 540
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 93.6 bits (231), Expect = 4e-19
Identities = 93/411 (22%), Positives = 170/411 (41%), Gaps = 42/411 (10%)
Query: 37 RTLQCTSVSLGKIPGNLS---EEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISV 93
R+L ++L +IP N E + + ++ L ++P + + L++L LN N I+
Sbjct: 215 RSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINR 274
Query: 94 IHLGALEHLPELRELRLEGN-KLCSVPWTAFRATPLLRVLDLKRN-KIDALPELALQFLV 151
I G ++ L+EL + +L S+ A P LR ++ N ++ + A L
Sbjct: 275 IRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLP 334
Query: 152 SLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGL 211
L L L+SN L+ + + P ++ +++H NP CDC +R +
Sbjct: 335 KLESLMLNSNALSALYHGTIESLPNLKE---------------ISIHSNPIRCDCVIRWM 379
Query: 212 VQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMK---PQISTPS--ANITIRA 266
+I + L C P GQ + M+ P I+ S +N+ + A
Sbjct: 380 NMNKTNIRF---MEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEA 436
Query: 267 GQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYT 326
G V+ C A A P P I W P + LT + L I + G YT
Sbjct: 437 GSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSE-GTLDINGVTPKEGGLYT 495
Query: 327 CMASNSIGKSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLRVVKQTVHGILLEWLAVA 386
C+A+N +G + + V S P + N +++++ + +L+ W A +
Sbjct: 496 CIATNLVGADLKSVMIKVDG----------SFPQDNNGSLNIKIRDIQANSVLVSWKASS 545
Query: 387 DTSKE--EWFTLYIASDEAFRKEVVHIGPGINTYAVDDLLPGTKYEACLSL 435
K +W T ++ ++ + + I + Y + L P T+Y+ C+ +
Sbjct: 546 KILKSSVKW-TAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDI 595
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 8/145 (5%)
Query: 22 PFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTL 81
P L G S+ + T++++ K+P LS V +E + L E+P+ +S L
Sbjct: 91 PVNLTGLDLSQNNLSSV---TNINVKKMPQLLS-----VYLEENKLTELPEKCLSELSNL 142
Query: 82 EYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDA 141
+ L++N N +S I GA L L L L N+L + F A P L +L + N I
Sbjct: 143 QELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIR 202
Query: 142 LPELALQFLVSLTYLDLSSNRLTVV 166
+ ++ + L++L L ++ LT +
Sbjct: 203 IKDMNFKPLINLRSLVIAGINLTEI 227
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 8/159 (5%)
Query: 15 LDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNL--SEEFKQVRIENSPLFEMPQ 72
L T +P+ P E S T+ C + L P L + + ++ N E
Sbjct: 32 LCTCEIRPWFTPRSIYMEAS---TVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 73 GSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVL 132
+N++ L+ L+ NN+S + ++ +P+L + LE NKL +P L+ L
Sbjct: 89 DFPVNLTGLD---LSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 133 DLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF 171
+ N + + A L +L L L+SNRL +++ F
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWF 184
Score = 37.0 bits (84), Expect = 0.047
Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 82 EYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDA 141
+ L L NNI+ I + L L L N L SV + P L + L+ NK+
Sbjct: 72 QILLLQTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 142 LPELALQFLVSLTYLDLSSNRLTVVSKSVFL 172
LPE L L +L L ++ N L+ +S F+
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFI 161
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 93.6 bits (231), Expect = 4e-19
Identities = 93/411 (22%), Positives = 170/411 (41%), Gaps = 42/411 (10%)
Query: 37 RTLQCTSVSLGKIPGNLS---EEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISV 93
R+L ++L +IP N E + + ++ L ++P + + L++L LN N I+
Sbjct: 215 RSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINR 274
Query: 94 IHLGALEHLPELRELRLEGN-KLCSVPWTAFRATPLLRVLDLKRN-KIDALPELALQFLV 151
I G ++ L+EL + +L S+ A P LR ++ N ++ + A L
Sbjct: 275 IRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLP 334
Query: 152 SLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGL 211
L L L+SN L+ + + P ++ +++H NP CDC +R +
Sbjct: 335 KLESLMLNSNALSALYHGTIESLPNLKE---------------ISIHSNPIRCDCVIRWM 379
Query: 212 VQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMK---PQISTPS--ANITIRA 266
+I + L C P GQ + M+ P I+ S +N+ + A
Sbjct: 380 NMNKTNIRF---MEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEA 436
Query: 267 GQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYT 326
G V+ C A A P P I W P + LT + L I + G YT
Sbjct: 437 GSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSE-GTLDINGVTPKEGGLYT 495
Query: 327 CMASNSIGKSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLRVVKQTVHGILLEWLAVA 386
C+A+N +G + + V S P + N +++++ + +L+ W A +
Sbjct: 496 CIATNLVGADLKSVMIKVDG----------SFPQDNNGSLNIKIRDIQANSVLVSWKASS 545
Query: 387 DTSKE--EWFTLYIASDEAFRKEVVHIGPGINTYAVDDLLPGTKYEACLSL 435
K +W T ++ ++ + + I + Y + L P T+Y+ C+ +
Sbjct: 546 KILKSSVKW-TAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDI 595
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 8/145 (5%)
Query: 22 PFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTL 81
P L G S+ + T++++ K+P LS V +E + L E+P+ +S L
Sbjct: 91 PVNLTGLDLSQNNLSSV---TNINVKKMPQLLS-----VYLEENKLTELPEKCLSELSNL 142
Query: 82 EYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDA 141
+ L++N N +S I GA L L L L N+L + F A P L +L + N I
Sbjct: 143 QELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIR 202
Query: 142 LPELALQFLVSLTYLDLSSNRLTVV 166
+ ++ + L++L L ++ LT +
Sbjct: 203 IKDMNFKPLINLRSLVIAGINLTEI 227
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 8/159 (5%)
Query: 15 LDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNL--SEEFKQVRIENSPLFEMPQ 72
L T +P+ P E S T+ C + L P L + + ++ N E
Sbjct: 32 LCTCEIRPWFTPRSIYMEAS---TVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 73 GSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVL 132
+N++ L+ L+ NN+S + ++ +P+L + LE NKL +P L+ L
Sbjct: 89 DFPVNLTGLD---LSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 133 DLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF 171
+ N + + A L +L L L+SNRL +++ F
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWF 184
Score = 37.0 bits (84), Expect = 0.047
Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 82 EYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDA 141
+ L L NNI+ I + L L L N L SV + P L + L+ NK+
Sbjct: 72 QILLLQTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 142 LPELALQFLVSLTYLDLSSNRLTVVSKSVFL 172
LPE L L +L L ++ N L+ +S F+
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFI 161
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 93.6 bits (231), Expect = 4e-19
Identities = 93/411 (22%), Positives = 170/411 (41%), Gaps = 42/411 (10%)
Query: 37 RTLQCTSVSLGKIPGNLS---EEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISV 93
R+L ++L +IP N E + + ++ L ++P + + L++L LN N I+
Sbjct: 215 RSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINR 274
Query: 94 IHLGALEHLPELRELRLEGN-KLCSVPWTAFRATPLLRVLDLKRN-KIDALPELALQFLV 151
I G ++ L+EL + +L S+ A P LR ++ N ++ + A L
Sbjct: 275 IRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLP 334
Query: 152 SLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGL 211
L L L+SN L+ + + P ++ +++H NP CDC +R +
Sbjct: 335 KLESLMLNSNALSALYHGTIESLPNLKE---------------ISIHSNPIRCDCVIRWM 379
Query: 212 VQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMK---PQISTPS--ANITIRA 266
+I + L C P GQ + M+ P I+ S +N+ + A
Sbjct: 380 NMNKTNIRF---MEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEA 436
Query: 267 GQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYT 326
G V+ C A A P P I W P + LT + L I + G YT
Sbjct: 437 GSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSE-GTLDINGVTPKEGGLYT 495
Query: 327 CMASNSIGKSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLRVVKQTVHGILLEWLAVA 386
C+A+N +G + + V S P + N +++++ + +L+ W A +
Sbjct: 496 CIATNLVGADLKSVMIKVDG----------SFPQDNNGSLNIKIRDIQANSVLVSWKASS 545
Query: 387 DTSKE--EWFTLYIASDEAFRKEVVHIGPGINTYAVDDLLPGTKYEACLSL 435
K +W T ++ ++ + + I + Y + L P T+Y+ C+ +
Sbjct: 546 KILKSSVKW-TAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDI 595
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 8/145 (5%)
Query: 22 PFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTL 81
P L G S+ + T++++ K+P LS V +E + L E+P+ +S L
Sbjct: 91 PVNLTGLDLSQNNLSSV---TNINVKKMPQLLS-----VYLEENKLTELPEKCLSELSNL 142
Query: 82 EYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDA 141
+ L++N N +S I GA L L L L N+L + F A P L +L + N I
Sbjct: 143 QELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIR 202
Query: 142 LPELALQFLVSLTYLDLSSNRLTVV 166
+ ++ + L++L L ++ LT +
Sbjct: 203 IKDMNFKPLINLRSLVIAGINLTEI 227
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 8/159 (5%)
Query: 15 LDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNL--SEEFKQVRIENSPLFEMPQ 72
L T +P+ P E S T+ C + L P L + + ++ N E
Sbjct: 32 LCTCEIRPWFTPRSIYMEAS---TVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 73 GSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVL 132
+N++ L+ L+ NN+S + ++ +P+L + LE NKL +P L+ L
Sbjct: 89 DFPVNLTGLD---LSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 133 DLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF 171
+ N + + A L +L L L+SNRL +++ F
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWF 184
Score = 37.0 bits (84), Expect = 0.047
Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 82 EYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDA 141
+ L L NNI+ I + L L L N L SV + P L + L+ NK+
Sbjct: 72 QILLLQTNNIAKIEYST-DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 142 LPELALQFLVSLTYLDLSSNRLTVVSKSVFL 172
LPE L L +L L ++ N L+ +S F+
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFI 161
>gi|194306623 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 92.0 bits (227), Expect = 1e-18
Identities = 85/380 (22%), Positives = 146/380 (38%), Gaps = 67/380 (17%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C ++ + C L ++P L + + + + + +G+F +++ +
Sbjct: 20 CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
LWL N + + GAL L +L+ L L N + S PW+ R L++L + N++ +LP
Sbjct: 80 LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV-VALHDNPW 202
AL L L L +++NRL ++ F + LS+L + L+ NP+
Sbjct: 140 RDALGALPDLRSLRINNNRLRTLAPGTF----------------DALSALSHLQLYHNPF 183
Query: 203 VCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQI------S 256
C C L L + S + + +S + C P + G + C P +
Sbjct: 184 HCGCGLVWLQAWAASTRVSLPEPDS-IACASPPALQGVPVYRLPALPCAPPSVHLSAEPP 242
Query: 257 TPSANITIRAGQNVTLRCLAQASPSPSIAWTY----------PLSMWREFDVLTSSTGED 306
+ +RAG L C+A P+P + W P + E D + + GE
Sbjct: 243 LEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEG 302
Query: 307 --------------------------------TALSELAIPAAHLVDSGNYTCMASNSIG 334
A L +P ++G YTC A N +G
Sbjct: 303 EGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELG 362
Query: 335 KSNLVISLHV-QPAQALHAP 353
++ I + V HAP
Sbjct: 363 ANSTSIRVAVAATGPPKHAP 382
Score = 33.5 bits (75), Expect = 0.52
Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 8/67 (11%)
Query: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTV-VLCV 472
G+N Y L PGT Y CL+L G+ H V F T ++ L L+ V V V +
Sbjct: 549 GVNAYWFRGLRPGTNYSVCLALAGEACHVQ--VVFSTKKELPSL-----LVIVAVSVFLL 601
Query: 473 VLLAVPV 479
VL VP+
Sbjct: 602 VLATVPL 608
>gi|194306621 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 92.0 bits (227), Expect = 1e-18
Identities = 85/380 (22%), Positives = 146/380 (38%), Gaps = 67/380 (17%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C ++ + C L ++P L + + + + + +G+F +++ +
Sbjct: 20 CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
LWL N + + GAL L +L+ L L N + S PW+ R L++L + N++ +LP
Sbjct: 80 LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV-VALHDNPW 202
AL L L L +++NRL ++ F + LS+L + L+ NP+
Sbjct: 140 RDALGALPDLRSLRINNNRLRTLAPGTF----------------DALSALSHLQLYHNPF 183
Query: 203 VCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQI------S 256
C C L L + S + + +S + C P + G + C P +
Sbjct: 184 HCGCGLVWLQAWAASTRVSLPEPDS-IACASPPALQGVPVYRLPALPCAPPSVHLSAEPP 242
Query: 257 TPSANITIRAGQNVTLRCLAQASPSPSIAWTY----------PLSMWREFDVLTSSTGED 306
+ +RAG L C+A P+P + W P + E D + + GE
Sbjct: 243 LEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEG 302
Query: 307 --------------------------------TALSELAIPAAHLVDSGNYTCMASNSIG 334
A L +P ++G YTC A N +G
Sbjct: 303 EGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELG 362
Query: 335 KSNLVISLHV-QPAQALHAP 353
++ I + V HAP
Sbjct: 363 ANSTSIRVAVAATGPPKHAP 382
Score = 33.5 bits (75), Expect = 0.52
Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 8/67 (11%)
Query: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTV-VLCV 472
G+N Y L PGT Y CL+L G+ H V F T ++ L L+ V V V +
Sbjct: 549 GVNAYWFRGLRPGTNYSVCLALAGEACHVQ--VVFSTKKELPSL-----LVIVAVSVFLL 601
Query: 473 VLLAVPV 479
VL VP+
Sbjct: 602 VLATVPL 608
>gi|39930401 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 92.0 bits (227), Expect = 1e-18
Identities = 85/380 (22%), Positives = 146/380 (38%), Gaps = 67/380 (17%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C ++ + C L ++P L + + + + + +G+F +++ +
Sbjct: 20 CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
LWL N + + GAL L +L+ L L N + S PW+ R L++L + N++ +LP
Sbjct: 80 LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV-VALHDNPW 202
AL L L L +++NRL ++ F + LS+L + L+ NP+
Sbjct: 140 RDALGALPDLRSLRINNNRLRTLAPGTF----------------DALSALSHLQLYHNPF 183
Query: 203 VCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQI------S 256
C C L L + S + + +S + C P + G + C P +
Sbjct: 184 HCGCGLVWLQAWAASTRVSLPEPDS-IACASPPALQGVPVYRLPALPCAPPSVHLSAEPP 242
Query: 257 TPSANITIRAGQNVTLRCLAQASPSPSIAWTY----------PLSMWREFDVLTSSTGED 306
+ +RAG L C+A P+P + W P + E D + + GE
Sbjct: 243 LEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEG 302
Query: 307 --------------------------------TALSELAIPAAHLVDSGNYTCMASNSIG 334
A L +P ++G YTC A N +G
Sbjct: 303 EGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELG 362
Query: 335 KSNLVISLHV-QPAQALHAP 353
++ I + V HAP
Sbjct: 363 ANSTSIRVAVAATGPPKHAP 382
Score = 33.5 bits (75), Expect = 0.52
Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 8/67 (11%)
Query: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTV-VLCV 472
G+N Y L PGT Y CL+L G+ H V F T ++ L L+ V V V +
Sbjct: 549 GVNAYWFRGLRPGTNYSVCLALAGEACHVQ--VVFSTKKELPSL-----LVIVAVSVFLL 601
Query: 473 VLLAVPV 479
VL VP+
Sbjct: 602 VLATVPL 608
>gi|194306618 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 92.0 bits (227), Expect = 1e-18
Identities = 85/380 (22%), Positives = 146/380 (38%), Gaps = 67/380 (17%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C ++ + C L ++P L + + + + + +G+F +++ +
Sbjct: 20 CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS 79
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
LWL N + + GAL L +L+ L L N + S PW+ R L++L + N++ +LP
Sbjct: 80 LWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLP 139
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLV-VALHDNPW 202
AL L L L +++NRL ++ F + LS+L + L+ NP+
Sbjct: 140 RDALGALPDLRSLRINNNRLRTLAPGTF----------------DALSALSHLQLYHNPF 183
Query: 203 VCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQI------S 256
C C L L + S + + +S + C P + G + C P +
Sbjct: 184 HCGCGLVWLQAWAASTRVSLPEPDS-IACASPPALQGVPVYRLPALPCAPPSVHLSAEPP 242
Query: 257 TPSANITIRAGQNVTLRCLAQASPSPSIAWTY----------PLSMWREFDVLTSSTGED 306
+ +RAG L C+A P+P + W P + E D + + GE
Sbjct: 243 LEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEG 302
Query: 307 --------------------------------TALSELAIPAAHLVDSGNYTCMASNSIG 334
A L +P ++G YTC A N +G
Sbjct: 303 EGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELG 362
Query: 335 KSNLVISLHV-QPAQALHAP 353
++ I + V HAP
Sbjct: 363 ANSTSIRVAVAATGPPKHAP 382
Score = 33.5 bits (75), Expect = 0.52
Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 8/67 (11%)
Query: 414 GINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTV-VLCV 472
G+N Y L PGT Y CL+L G+ H V F T ++ L L+ V V V +
Sbjct: 549 GVNAYWFRGLRPGTNYSVCLALAGEACHVQ--VVFSTKKELPSL-----LVIVAVSVFLL 601
Query: 473 VLLAVPV 479
VL VP+
Sbjct: 602 VLATVPL 608
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 89.0 bits (219), Expect = 1e-17
Identities = 67/191 (35%), Positives = 93/191 (48%), Gaps = 12/191 (6%)
Query: 19 AAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINM 78
AA P C C+C + R + C+ L +P LS + + I + + ++P+ +F N
Sbjct: 24 AAPPLCAAPCSCDGD---RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNF 80
Query: 79 STLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNK 138
LE L L N++S IH AL L EL+ L L+ N+L +VP A R L+ L L N
Sbjct: 81 PFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANH 140
Query: 139 IDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQ--------PDCGAEIL 190
I ++PE + + LV L +L L N LT V N P Q PD L
Sbjct: 141 ITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNL 200
Query: 191 SSLVVA-LHDN 200
SSLVV LH+N
Sbjct: 201 SSLVVLHLHNN 211
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/106 (33%), Positives = 60/106 (56%)
Query: 58 KQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCS 117
+ +R++ + + +P+ SF + L +LWL+ N+++ + + L +LP L+ L L NK+ S
Sbjct: 132 QSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISS 191
Query: 118 VPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRL 163
+P AF L VL L NKI +L + L +L LDL+ N L
Sbjct: 192 IPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL 237
Score = 52.4 bits (124), Expect = 1e-06
Identities = 41/138 (29%), Positives = 66/138 (47%), Gaps = 4/138 (2%)
Query: 37 RTLQCTSVSLGKIPGNLSEEFKQVR---IENSPLFEMPQGSFINMSTLEYLWLNFNNISV 93
++L+ + + +P + E Q+R ++++ L E+P N+ TL+ L L N IS
Sbjct: 132 QSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISS 191
Query: 94 IHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSL 153
I A +L L L L NK+ S+ F L LDL N + P+ A++ L SL
Sbjct: 192 IPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ-AIKALPSL 250
Query: 154 TYLDLSSNRLTVVSKSVF 171
L SN ++V+ F
Sbjct: 251 KELGFHSNSISVIPDGAF 268
Score = 49.3 bits (116), Expect = 9e-06
Identities = 38/123 (30%), Positives = 57/123 (46%), Gaps = 9/123 (7%)
Query: 38 TLQCTSVSLGKIPG-------NLSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNN 90
TLQ +++L KI NLS + + N+ + + Q F + LE L LN+NN
Sbjct: 178 TLQALTLALNKISSIPDFAFTNLSS-LVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
Query: 91 ISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFL 150
+ A++ LP L+EL N + +P AF PLLR + L N + + A L
Sbjct: 237 LGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
Query: 151 VSL 153
L
Sbjct: 296 SDL 298
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/127 (29%), Positives = 56/127 (44%), Gaps = 23/127 (18%)
Query: 38 TLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLG 97
+L T + IP NL +E K +R TL+ L++NNI L
Sbjct: 323 SLTLTGTKISSIPNNLCQEQKMLR------------------TLD---LSYNNIR--DLP 359
Query: 98 ALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLD 157
+ L E+ L+ N++ + F+ LR+LDL RN I + A L +T LD
Sbjct: 360 SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLD 419
Query: 158 LSSNRLT 164
+S N LT
Sbjct: 420 VSFNELT 426
Score = 38.1 bits (87), Expect = 0.021
Identities = 36/136 (26%), Positives = 54/136 (39%), Gaps = 23/136 (16%)
Query: 58 KQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCS 117
+ + + ++PL + +F N+S L L + ++ V L L L L G K+ S
Sbjct: 275 RTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASM-VQQFPNLTGTVHLESLTLTGTKISS 333
Query: 118 VPWTAFRATPLLRVLDLKRNKIDALP----------------------ELALQFLVSLTY 155
+P + +LR LDL N I LP E Q L+SL
Sbjct: 334 IPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRI 393
Query: 156 LDLSSNRLTVVSKSVF 171
LDLS N + + F
Sbjct: 394 LDLSRNLIHEIHSRAF 409
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 86.3 bits (212), Expect = 7e-17
Identities = 59/192 (30%), Positives = 88/192 (45%), Gaps = 19/192 (9%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C CTCS + C L +IP NL E ++R+E + + +P G+F L
Sbjct: 273 CPAACTCSNN----IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 328
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
+ L+ N IS + A + L L L L GNK+ +P + F L++L L NKI+ L
Sbjct: 329 IDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWV 203
A Q L +L L L N+L ++K F A Q + L NP++
Sbjct: 389 VDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQ---------------TMHLAQNPFI 433
Query: 204 CDCRLRGLVQFV 215
CDC L+ L ++
Sbjct: 434 CDCHLKWLADYL 445
Score = 81.6 bits (200), Expect = 2e-15
Identities = 70/249 (28%), Positives = 102/249 (40%), Gaps = 24/249 (9%)
Query: 10 LVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFE 69
LVL L+ A Q C C+CS G T+ C ++L +P N+ +++ + + +
Sbjct: 15 LVLAILNKVAPQA-CPAQCSCS----GSTVDCHGLALRSVPRNIPRNTERLDLNGNNITR 69
Query: 70 MPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLL 129
+ + F + L L L N IS I GA + L EL LRL N L P F T L
Sbjct: 70 ITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKL 129
Query: 130 RVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEI 189
LDL N+I A+P A + V + L L N+++ + F A +
Sbjct: 130 YRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAF---RALRDLEVLTLNNNN 186
Query: 190 LSSLVVA------------LHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSK 237
++ L VA LH N CDC L L +++ V Y C GP
Sbjct: 187 ITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRP----RVGLYTQCMGPSHL 242
Query: 238 AGQLFHETE 246
G E +
Sbjct: 243 RGHNVAEVQ 251
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/195 (25%), Positives = 87/195 (44%), Gaps = 22/195 (11%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQ-GSFINMSTLE 82
C C C G T+ C++ L KIP ++ + ++R+ N+ + G F + L
Sbjct: 506 CPEKCRCE----GTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLR 561
Query: 83 YLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDAL 142
+ + N I+ I GA E + E+ L N+L +V F+ L+ L L+ N+I +
Sbjct: 562 KINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCV 621
Query: 143 PELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSL-VVALHDNP 201
+ L S+ L L N++T V+ F + L SL + L NP
Sbjct: 622 GNDSFIGLSSVRLLSLYDNQITTVAPGAF----------------DTLHSLSTLNLLANP 665
Query: 202 WVCDCRLRGLVQFVK 216
+ C+C L L ++++
Sbjct: 666 FNCNCYLAWLGEWLR 680
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/248 (23%), Positives = 102/248 (41%), Gaps = 37/248 (14%)
Query: 16 DTHAAQPF--CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQG 73
D ++ P C CTC + ++C++ L +P + + ++ ++ + +P+
Sbjct: 717 DDNSCSPLSRCPTECTCLDT----VVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK- 771
Query: 74 SFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLD 133
N L + L+ N IS + + ++ +L L L N+L +P F LR+L
Sbjct: 772 ELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLS 831
Query: 134 LKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSL 193
L N I +PE A L +L++L + +N P Y C DC + LS
Sbjct: 832 LHGNDISVVPEGAFNDLSALSHLAIGAN-------------PLY--C---DCNMQWLSDW 873
Query: 194 VVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKP 253
V + + P + C G + +T P + CQGP+ + + A P
Sbjct: 874 VKSEYKEPGIARCAGPGEMADKLLLTTP----SKKFTCQGPV--------DVNILAKCNP 921
Query: 254 QISTPSAN 261
+S P N
Sbjct: 922 CLSNPCKN 929
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 85.9 bits (211), Expect = 9e-17
Identities = 83/315 (26%), Positives = 130/315 (41%), Gaps = 26/315 (8%)
Query: 26 PGCTCSEES--FGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
PG C F T++C + L +P ++ + + + + + E+ G+F + L
Sbjct: 32 PGAGCPSRCLCFRTTVRCMHLLLEAVPA-VAPQTSILDLRFNRIREIQPGAFRRLRNLNT 90
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
L LN N I I GA E L L+ L L N++ S+ AF+ L L L N+I+ L
Sbjct: 91 LLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLD 150
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWV 203
+ Q L L L L +NR+T + F + + ++ R L N
Sbjct: 151 PDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLR---------------LDSNTLH 195
Query: 204 CDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQ---LFHETELSACMKPQISTPSA 260
CDC + L +K+ + IC+ P G+ EL+ C +P+I++
Sbjct: 196 CDCEILWLADLLKTYA-ESGNAQAAAICEYPRRIQGRSVATITPEELN-CERPRITSEPQ 253
Query: 261 NITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLV 320
+ + +G V C A+ +P P I W L E + T S L I
Sbjct: 254 DADVTSGNTVYFTCRAEGNPKPEIIW---LRNNNELSMKTDSRLNLLDDGTLMIQNTQET 310
Query: 321 DSGNYTCMASNSIGK 335
D G Y CMA N G+
Sbjct: 311 DQGIYQCMAKNVAGE 325
Score = 55.1 bits (131), Expect = 2e-07
Identities = 42/121 (34%), Positives = 53/121 (43%), Gaps = 14/121 (11%)
Query: 253 PQISTPSANITIRAGQNVTLRCLAQASPSPSIAWT---YPLSMWREFDVLTSSTGEDTAL 309
PQ + + + GQ V +C A+ +P P IAWT LS+ R VL+S T
Sbjct: 433 PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT------ 486
Query: 310 SELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLR 369
L I L D G Y C A N IG +V L VQP P SIPS+ +
Sbjct: 487 --LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRV---TPVFASIPSDTTVEVGAN 541
Query: 370 V 370
V
Sbjct: 542 V 542
Score = 53.1 bits (126), Expect = 6e-07
Identities = 75/351 (21%), Positives = 136/351 (38%), Gaps = 53/351 (15%)
Query: 38 TLQCTSVSLGKIPGNLSEEFKQVR---IENSPLFEMPQGSFINMSTLEYLWLNFNNISVI 94
TL + + +IP E+ + ++ + + + + + +F +++LE L+L+FN I +
Sbjct: 90 TLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETL 149
Query: 95 HLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLT 154
+ +HLP+L L L N++ + F ++ L L N + E+ + T
Sbjct: 150 DPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKT 209
Query: 155 YLDLSSNRLTVV--------SKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDC 206
Y + + + + +SV P C +P +E + V + N C
Sbjct: 210 YAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTS--GNTVYFTC 267
Query: 207 RLRGL----VQFVKSITLPVILVNSYLICQGPLSKAGQLFHETE--LSACM--------- 251
R G + ++++ + +S L + Q ET+ + CM
Sbjct: 268 RAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVK 327
Query: 252 -------------KPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWT----YPLSMWR 294
+P N + G++VTL C A P P I+WT PL +
Sbjct: 328 TQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDP 387
Query: 295 EFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQ 345
++ T S G L I DSG Y C A+N+I + + VQ
Sbjct: 388 RVNI-TPSGG-------LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQ 430
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/128 (25%), Positives = 56/128 (43%), Gaps = 11/128 (8%)
Query: 253 PQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSE- 311
P ++ ++ T+ G NV L C +Q P P+I W + V + +G+ E
Sbjct: 525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAIT-------WNKDGVQVTESGKFHISPEG 577
Query: 312 -LAIPAAHLVDSGNYTCMASNSIGKS--NLVISLHVQPAQALHAPDSLSIPSEGNAYIDL 368
L I D+G Y C+A N+IG + ++V+S++V P + E A +D
Sbjct: 578 FLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDR 637
Query: 369 RVVKQTVH 376
+ H
Sbjct: 638 AINSTRTH 645
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 85.9 bits (211), Expect = 9e-17
Identities = 59/193 (30%), Positives = 89/193 (46%), Gaps = 19/193 (9%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C CTCS + C L +IP NL E ++R+E + + +P G+F L+
Sbjct: 280 CPSPCTCSNN----IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKR 335
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
+ ++ N IS I A + L L L L GNK+ + F L++L L NKI+ L
Sbjct: 336 IDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLR 395
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWV 203
Q L +L L L N+L +SK +F A + S + L NP+V
Sbjct: 396 VNTFQDLQNLNLLSLYDNKLQTISKGLF---------------APLQSIQTLHLAQNPFV 440
Query: 204 CDCRLRGLVQFVK 216
CDC L+ L +++
Sbjct: 441 CDCHLKWLADYLQ 453
Score = 85.1 bits (209), Expect = 2e-16
Identities = 63/251 (25%), Positives = 106/251 (42%), Gaps = 23/251 (9%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C CTCS S + C + L +P + +++ ++ + + + + F + L
Sbjct: 34 CPTKCTCSAAS----VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRV 89
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
L L N +SVI GA + L +L LRL NKL +P F++TP L LDL N+I +P
Sbjct: 90 LHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIP 149
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVF--LNWPAYQKCRQPDCGAEILSSL-------V 194
A + + + L L +N ++ + F L + +++S
Sbjct: 150 RKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRT 209
Query: 195 VALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELS----AC 250
+ LH N CDC L L +++ V + +C P+ G F+ ++ C
Sbjct: 210 LRLHSNHLYCDCHLAWLSDWLRQRR----TVGQFTLCMAPVHLRG--FNVADVQKKEYVC 263
Query: 251 MKPQISTPSAN 261
P PS N
Sbjct: 264 PAPHSEPPSCN 274
Score = 63.5 bits (153), Expect = 5e-10
Identities = 49/194 (25%), Positives = 85/194 (43%), Gaps = 20/194 (10%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQ-GSFINMSTLE 82
C C C G + C++ L +IP +L E +R+ ++ + + G F + L
Sbjct: 505 CPEKCRCE----GTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560
Query: 83 YLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDAL 142
+ L+ N I + GA + ++EL L GN+L +V FR L+ L L+ N I +
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCV 620
Query: 143 PELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPW 202
L S+ L L NR+T ++ F ++S + L NP+
Sbjct: 621 SNDTFAGLSSVRLLSLYDNRITTITPGAF---------------TTLVSLSTINLLSNPF 665
Query: 203 VCDCRLRGLVQFVK 216
C+C L L ++++
Sbjct: 666 NCNCHLAWLGKWLR 679
Score = 60.1 bits (144), Expect = 5e-09
Identities = 51/188 (27%), Positives = 83/188 (44%), Gaps = 29/188 (15%)
Query: 22 PFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTL 81
P C CTC E ++C++ L +P + ++ ++ +E + L +P+ +S L
Sbjct: 723 PRCPEQCTCMET----VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR----ELSAL 774
Query: 82 EYLWL---NFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNK 138
+L L + N+IS++ ++ L L L N+L +P AF LRVL L N
Sbjct: 775 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGND 834
Query: 139 IDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALH 198
I ++PE + L SL++L L +N L DC LS V A +
Sbjct: 835 ISSVPEGSFNDLTSLSHLALGTNPL------------------HCDCSLRWLSEWVKAGY 876
Query: 199 DNPWVCDC 206
P + C
Sbjct: 877 KEPGIARC 884
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/194 (29%), Positives = 90/194 (46%), Gaps = 19/194 (9%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C CTCS + C L IP NL E ++R+E + + +P G+F L
Sbjct: 282 CPAMCTCSNG----IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRR 337
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
+ L+ N I+ I A + L L L L GNK+ +P F L++L L NKI+ +
Sbjct: 338 IDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIR 397
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWV 203
A Q L +L+ L L N++ ++K F + A Q + L NP++
Sbjct: 398 PDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQ---------------TLHLAQNPFI 442
Query: 204 CDCRLRGLVQFVKS 217
CDC L+ L F+++
Sbjct: 443 CDCNLKWLADFLRT 456
Score = 79.0 bits (193), Expect = 1e-14
Identities = 61/234 (26%), Positives = 94/234 (40%), Gaps = 17/234 (7%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C CTC+ G T+ C L IP N+ +++ + + + + + F + L
Sbjct: 34 CPALCTCT----GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRV 89
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
L L N I + GA + + EL LRL N+L +P F+ L LDL N I A+P
Sbjct: 90 LQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIP 149
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVF--LNWPAYQKCRQPDCGAEILSSL-------V 194
A + L L L N+++ + + F L + +SS
Sbjct: 150 RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRT 209
Query: 195 VALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELS 248
LH N CDC L L Q+++ + + C GP S G E + S
Sbjct: 210 FRLHSNHLFCDCHLAWLSQWLRQRP----TIGLFTQCSGPASLRGLNVAEVQKS 259
Score = 65.9 bits (159), Expect = 9e-11
Identities = 53/190 (27%), Positives = 87/190 (45%), Gaps = 22/190 (11%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQ-GSFINMSTLE 82
C C C ++C+S+ L KIP + + ++R+ N+ + + G F ++ L+
Sbjct: 513 CPHKCRCE----ANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568
Query: 83 YLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDAL 142
+ L+ N +S I GA E + EL L N+L S+ FR LR L L+ N+I +
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
Query: 143 PELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSL-VVALHDNP 201
+ L ++ L L N++T VS F + L SL + L NP
Sbjct: 629 HNDSFTGLRNVRLLSLYDNQITTVSPGAF----------------DTLQSLSTLNLLANP 672
Query: 202 WVCDCRLRGL 211
+ C+C+L L
Sbjct: 673 FNCNCQLAWL 682
Score = 58.2 bits (139), Expect = 2e-08
Identities = 52/186 (27%), Positives = 82/186 (44%), Gaps = 23/186 (12%)
Query: 60 VRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVP 119
VR N L +P+G N++ L +L+ N +++ G L L+ + L NK+ S+
Sbjct: 745 VRCSNKHLRALPKGIPKNVTEL---YLDGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLS 800
Query: 120 WTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQK 179
++F L L L N + +P LA Q L SL L L N ++ + + +F
Sbjct: 801 NSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIF-------- 852
Query: 180 CRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAG 239
A++ S +A+ NP CDC LR L +VK+ + C GP G
Sbjct: 853 -------ADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIAR----CAGPQDMEG 901
Query: 240 QLFHET 245
+L T
Sbjct: 902 KLLLTT 907
Score = 39.7 bits (91), Expect = 0.007
Identities = 52/194 (26%), Positives = 76/194 (39%), Gaps = 48/194 (24%)
Query: 49 IPGNLS--EEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELR 106
+PG LS + + V + N+ + + SF NMS L L L++N AL+ +P L
Sbjct: 776 VPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYN--------ALQCIPPL- 826
Query: 107 ELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVV 166
AF+ LR+L L N I L E + SL++L + +N
Sbjct: 827 ---------------AFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN----- 866
Query: 167 SKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVN 226
P Y C DC LSS V + P + C ++ +T P
Sbjct: 867 --------PLY--C---DCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPA---- 909
Query: 227 SYLICQGPLSKAGQ 240
CQGP + A Q
Sbjct: 910 KKFECQGPPTLAVQ 923
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 84.0 bits (206), Expect = 3e-16
Identities = 76/335 (22%), Positives = 129/335 (38%), Gaps = 39/335 (11%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C E+ + C L +P + + + L +P+G+F + L+
Sbjct: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
LWL N I + GAL L L+ L L N + W+ L++L + N++ +P
Sbjct: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWV 203
A + L +L L L+ NRL +++ F A LS L +++NP+
Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA-------------LSHL--QINENPFD 183
Query: 204 CDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQIS---TPSA 260
C C + L + + T I + C P G C P + PS
Sbjct: 184 CTCGIVWLKTWALT-TAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQ 242
Query: 261 N-ITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGED------------- 306
+ +R G + L C P+P + W + ++ + + G D
Sbjct: 243 DGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS-GIVEITSPNVGTDGRALPGTPVASSQ 301
Query: 307 -----TALSELAIPAAHLVDSGNYTCMASNSIGKS 336
A L IP ++ G Y+C+A+N +G +
Sbjct: 302 PRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 84.0 bits (206), Expect = 3e-16
Identities = 76/335 (22%), Positives = 129/335 (38%), Gaps = 39/335 (11%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C E+ + C L +P + + + L +P+G+F + L+
Sbjct: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
LWL N I + GAL L L+ L L N + W+ L++L + N++ +P
Sbjct: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWV 203
A + L +L L L+ NRL +++ F A LS L +++NP+
Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTA-------------LSHL--QINENPFD 183
Query: 204 CDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQIS---TPSA 260
C C + L + + T I + C P G C P + PS
Sbjct: 184 CTCGIVWLKTWALT-TAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQ 242
Query: 261 N-ITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGED------------- 306
+ +R G + L C P+P + W + ++ + + G D
Sbjct: 243 DGAELRPGFVLALHCDVDGQPAPQLHWHIQIPS-GIVEITSPNVGTDGRALPGTPVASSQ 301
Query: 307 -----TALSELAIPAAHLVDSGNYTCMASNSIGKS 336
A L IP ++ G Y+C+A+N +G +
Sbjct: 302 PRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSA 336
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/475 (24%), Positives = 184/475 (38%), Gaps = 89/475 (18%)
Query: 74 SFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLD 133
+F ++ L L L N+ I ALE L L L N+L VP A P L+ LD
Sbjct: 208 NFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLD 267
Query: 134 LKRNKID-------------------------ALPELALQFLVSLTYLDLSSN-RLTVVS 167
L +N + ++ + AL L LT LD+++N RL+ +
Sbjct: 268 LNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIH 327
Query: 168 KSVFLNWPAYQKCRQPDCGAEILSSLVV---------ALHDNPWVCDCRLRGL------V 212
F + P + + L V LH NP CDC +R V
Sbjct: 328 PRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRV 387
Query: 213 QFVKSITLPVILVNSYLICQGPLSKAGQLFHET---ELSACMKPQISTPS--ANITIRAG 267
+F++ + +C P E E++ P IS S ++ + +G
Sbjct: 388 RFIEPQST---------LCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASG 438
Query: 268 QNVTLRCLAQASPSPSIAWTYPLSM-------WREFDVLTSSTGEDTALSELAIPAAHLV 320
+++ L C A A P P I W P + R + V T L +
Sbjct: 439 ESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT--------LELRRVTAE 490
Query: 321 DSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLRVVKQTVHGILL 380
++G YTC+A N +G +S+ V +AL P EG ++LRV + + ILL
Sbjct: 491 EAGLYTCVAQNLVGADTKTVSVVV--GRALLQPGR----DEGQG-LELRVQETHPYHILL 543
Query: 381 EWLAVADTSKEEWFTLYIASDEAFRKE----VVHIGPGINTYAVDDLLPGTKYEACLSLE 436
W+ +T L +S + R + + + G ++Y + LL T+Y ACL +
Sbjct: 544 SWVTPPNTVST---NLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
Query: 437 GQPPHQGQCVAFVTGRDA----GGLEAREHLLHVTVVLCVVLLAVPVGAYAWAAQ 487
H + ++A L R L+ + + L V+LLA + A+ Q
Sbjct: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAI-LALAVLLLAAGLAAHLGTGQ 654
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/108 (28%), Positives = 53/108 (49%)
Query: 60 VRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVP 119
+ +E + L + SF +++L+ L+LN N + I A L L L L N L ++
Sbjct: 122 LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAID 181
Query: 120 WTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVS 167
F P L +L + NK+DA+ ++ + L +L L L+ L +S
Sbjct: 182 SRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
Score = 43.9 bits (102), Expect = 4e-04
Identities = 38/157 (24%), Positives = 64/157 (40%), Gaps = 9/157 (5%)
Query: 24 CLPGCTC---------SEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGS 74
C P C C S T+ C + L +P L + + ++++ + + Q
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 75 FINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDL 134
++ L L L+ N+ S LP+L L LE N+L + +F L+ L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 135 KRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF 171
N++ + A L +L L L+SN L + F
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWF 185
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/111 (28%), Positives = 53/111 (47%)
Query: 58 KQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCS 117
+++ + ++ L+ + +F +S L L LN N + I E LP L L + GNK+ +
Sbjct: 144 QELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDA 203
Query: 118 VPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSK 168
+ FR LR L L + + + AL+ L SL L N+L V +
Sbjct: 204 ILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPR 254
Score = 38.9 bits (89), Expect = 0.012
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 56 EFKQVRIENSP-LFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNK 114
E ++ I N+P L + +F ++ +E L LN N +S +H +E LP L+E+ L GN
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNP 370
Query: 115 L---CSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF 171
+ C + W T +R ++ + P+L + + + +++ + L ++S F
Sbjct: 371 IRCDCVIRWANATGT-RVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSF 429
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/475 (24%), Positives = 184/475 (38%), Gaps = 89/475 (18%)
Query: 74 SFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLD 133
+F ++ L L L N+ I ALE L L L N+L VP A P L+ LD
Sbjct: 208 NFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLD 267
Query: 134 LKRNKID-------------------------ALPELALQFLVSLTYLDLSSN-RLTVVS 167
L +N + ++ + AL L LT LD+++N RL+ +
Sbjct: 268 LNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIH 327
Query: 168 KSVFLNWPAYQKCRQPDCGAEILSSLVV---------ALHDNPWVCDCRLRGL------V 212
F + P + + L V LH NP CDC +R V
Sbjct: 328 PRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRV 387
Query: 213 QFVKSITLPVILVNSYLICQGPLSKAGQLFHET---ELSACMKPQISTPS--ANITIRAG 267
+F++ + +C P E E++ P IS S ++ + +G
Sbjct: 388 RFIEPQST---------LCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASG 438
Query: 268 QNVTLRCLAQASPSPSIAWTYPLSM-------WREFDVLTSSTGEDTALSELAIPAAHLV 320
+++ L C A A P P I W P + R + V T L +
Sbjct: 439 ESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGT--------LELRRVTAE 490
Query: 321 DSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLRVVKQTVHGILL 380
++G YTC+A N +G +S+ V +AL P EG ++LRV + + ILL
Sbjct: 491 EAGLYTCVAQNLVGADTKTVSVVV--GRALLQPGR----DEGQG-LELRVQETHPYHILL 543
Query: 381 EWLAVADTSKEEWFTLYIASDEAFRKE----VVHIGPGINTYAVDDLLPGTKYEACLSLE 436
W+ +T L +S + R + + + G ++Y + LL T+Y ACL +
Sbjct: 544 SWVTPPNTVST---NLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA 600
Query: 437 GQPPHQGQCVAFVTGRDA----GGLEAREHLLHVTVVLCVVLLAVPVGAYAWAAQ 487
H + ++A L R L+ + + L V+LLA + A+ Q
Sbjct: 601 FADAHTQLACVWARTKEATSCHRALGDRPGLIAI-LALAVLLLAAGLAAHLGTGQ 654
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/108 (28%), Positives = 53/108 (49%)
Query: 60 VRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVP 119
+ +E + L + SF +++L+ L+LN N + I A L L L L N L ++
Sbjct: 122 LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAID 181
Query: 120 WTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVS 167
F P L +L + NK+DA+ ++ + L +L L L+ L +S
Sbjct: 182 SRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREIS 229
Score = 43.9 bits (102), Expect = 4e-04
Identities = 38/157 (24%), Positives = 64/157 (40%), Gaps = 9/157 (5%)
Query: 24 CLPGCTC---------SEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGS 74
C P C C S T+ C + L +P L + + ++++ + + Q
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 75 FINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDL 134
++ L L L+ N+ S LP+L L LE N+L + +F L+ L L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 135 KRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF 171
N++ + A L +L L L+SN L + F
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWF 185
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/111 (28%), Positives = 53/111 (47%)
Query: 58 KQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCS 117
+++ + ++ L+ + +F +S L L LN N + I E LP L L + GNK+ +
Sbjct: 144 QELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDA 203
Query: 118 VPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSK 168
+ FR LR L L + + + AL+ L SL L N+L V +
Sbjct: 204 ILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPR 254
Score = 38.9 bits (89), Expect = 0.012
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 56 EFKQVRIENSP-LFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNK 114
E ++ I N+P L + +F ++ +E L LN N +S +H +E LP L+E+ L GN
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNP 370
Query: 115 L---CSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVF 171
+ C + W T +R ++ + P+L + + + +++ + L ++S F
Sbjct: 371 IRCDCVIRWANATGT-RVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSF 429
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 80.9 bits (198), Expect = 3e-15
Identities = 95/411 (23%), Positives = 162/411 (39%), Gaps = 51/411 (12%)
Query: 55 EEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEH-LPELRELRLEGN 113
E + + ++++ L + + + + L++L +N N + I A E L L +L L N
Sbjct: 100 ESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYN 159
Query: 114 KLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKS-VFL 172
L +PW + R L L L N +D + E L L LDL+SNRL + +F
Sbjct: 160 NLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFA 219
Query: 173 NWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQ 232
A P L + NP C+C L L + + L C
Sbjct: 220 RSQASALTATP-----FAPPLSFSFGGNPLHCNCELLWLRRLERDDDLET--------CG 266
Query: 233 GPLSKAGQLFHET--ELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPL 290
P G+ F E C P I+ + + + GQ TL+C A PSP I W P
Sbjct: 267 SPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPD 326
Query: 291 SMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISL------HV 344
R + + D ++ I + DSG +TC+A+N+ G++ ++ + H+
Sbjct: 327 D--RLVGNSSRTAVYDNGTLDIFITTSQ--DSGAFTCIAANAAGEATAMVEVSIVQLPHL 382
Query: 345 QPAQALHAPDSLSI--------------------PSEGNAYIDLRVVKQTVHGILLEWLA 384
+ + AP + P + + V + T L++W
Sbjct: 383 SNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVLVSEVTTTSALVKWSV 442
Query: 385 VADTSKEEWFTL-YIASDEAFRKEVVHIGPGIN-TYAVDDLLPGTKYEACL 433
+ + + L Y SD+ + + P N + V++L+ GT Y+ C+
Sbjct: 443 SKSAPRVKMYQLQYNCSDDEVL--IYRMIPASNKAFVVNNLVSGTGYDLCV 491
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 80.5 bits (197), Expect = 4e-15
Identities = 56/190 (29%), Positives = 88/190 (46%), Gaps = 17/190 (8%)
Query: 20 AQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMS 79
A P C C C S + C+ + L +P ++ + + + N+ L +P +F N+S
Sbjct: 35 ALPTCPFSCKCDSRSL--EVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLS 92
Query: 80 TLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKI 139
+L+ L L+ N + + L L EL+L N + ++ R +PLLR LDL N +
Sbjct: 93 SLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGL 152
Query: 140 DALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHD 199
LP L++L L L SNRL + + F +P ++L + D
Sbjct: 153 AQLPPGLFDGLLALRSLSLRSNRLQNLDRLTF----------EPLANLQLLQ-----VGD 197
Query: 200 NPWVCDCRLR 209
NPW CDC LR
Sbjct: 198 NPWECDCNLR 207
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 80.1 bits (196), Expect = 5e-15
Identities = 88/360 (24%), Positives = 141/360 (39%), Gaps = 37/360 (10%)
Query: 38 TLQCTSVSLGKIPGNLSEEFKQV---RIENSPLFEMPQGSFINMSTLEYLWLN-FNNISV 93
TL +L +PG + R+ + +P G+ + L+ L ++ + ++
Sbjct: 184 TLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEA 243
Query: 94 IHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSL 153
+ G+L L L L + L SVP+ A LRVLDL +N I A+P L LV L
Sbjct: 244 LDPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRL 302
Query: 154 TYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSS---------LVVALHDNPWVC 204
L LS LT ++ F A+ D + L + + L NP C
Sbjct: 303 QELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTC 362
Query: 205 DCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQLFHE-----TELSACMKPQISTPS 259
DCRL L++ + + + S C GP G+ E KP + S
Sbjct: 363 DCRLLWLLRLRRHLDFGM----SPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKS 418
Query: 260 AN--ITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSE--LAIP 315
+ G + C P+P+++W P W G L + L I
Sbjct: 419 GPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAW------LGRAGRVRVLEDGTLEIR 472
Query: 316 AAHLVDSGNYTCMASNSIGKSNL---VISLHVQPAQALHAPDSLSIPS-EGNAYIDLRVV 371
+ L D G Y C+ SN G +L + + V+P + ++++P G ++D R V
Sbjct: 473 SVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNITVPGIPGPFFLDSRGV 532
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/173 (26%), Positives = 76/173 (43%), Gaps = 2/173 (1%)
Query: 24 CLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEY 83
C C C+ + + + C L +PG L + + + + + L+ + QG +S L+
Sbjct: 31 CPAVCDCTSQP--QAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQE 88
Query: 84 LWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALP 143
L L++N +S + GA L L LRL+GN+L + F L +LDL+ N+I
Sbjct: 89 LDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFL 148
Query: 144 ELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVA 196
+ A L SL L++ N L V+ F C + L +A
Sbjct: 149 DGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALA 201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,754,750
Number of Sequences: 37866
Number of extensions: 1069693
Number of successful extensions: 6082
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 331
Number of HSP's successfully gapped in prelim test: 193
Number of HSP's that attempted gapping in prelim test: 2702
Number of HSP's gapped (non-prelim): 2269
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.