Search of human proteins with 62899035

Search of human proteins with 62899035

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62899035 establishment of cohesion 1 homolog 2 [Homo
sapiens]
         (601 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62899035 establishment of cohesion 1 homolog 2 [Homo sapiens]     1215   0.0  
gi|116235478 establishment of cohesion 1 homolog 1 [Homo sapiens]     311   1e-84
gi|67551265 transcription factor ELYS [Homo sapiens]                   43   7e-04
gi|95147342 chromodomain helicase DNA binding protein 9 [Homo sa...    40   0.006
gi|90669307 cyclin B3 isoform 3 [Homo sapiens]                         39   0.014
gi|150170670 piccolo isoform 2 [Homo sapiens]                          37   0.052
gi|150378539 piccolo isoform 1 [Homo sapiens]                          37   0.052
gi|171184451 centrosome-associated protein 350 [Homo sapiens]          37   0.052
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    37   0.068
gi|110815815 centlein isoform 1 [Homo sapiens]                         36   0.089
gi|223555917 metadherin [Homo sapiens]                                 36   0.12 
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    36   0.12 
gi|110349719 titin isoform N2-A [Homo sapiens]                         35   0.20 
gi|110349717 titin isoform novex-2 [Homo sapiens]                      35   0.20 
gi|110349713 titin isoform novex-1 [Homo sapiens]                      35   0.20 
gi|110349715 titin isoform N2-B [Homo sapiens]                         35   0.20 
gi|65507253 hypothetical protein LOC55196 [Homo sapiens]               35   0.20 
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                   35   0.26 
gi|215982794 myosin VA isoform 2 [Homo sapiens]                        34   0.34 
gi|34996489 pleckstrin homology domain interacting protein [Homo...    34   0.34 
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                  34   0.34 
gi|4826894 phosphodiesterase 1C [Homo sapiens]                         34   0.44 
gi|216548091 leucine zipper protein 1 [Homo sapiens]                   34   0.44 
gi|216548085 leucine zipper protein 1 [Homo sapiens]                   34   0.44 
gi|187608809 hypothetical protein LOC23240 isoform 2 [Homo sapiens]    34   0.44 
gi|196114949 hypothetical protein LOC23240 isoform 1 [Homo sapiens]    34   0.44 
gi|4506325 protein tyrosine phosphatase, receptor type, R isofor...    33   0.58 
gi|7549793 transducin (beta)-like 2 [Homo sapiens]                     33   0.58 
gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens]        33   0.58 
gi|40068059 CBF1 interacting corepressor [Homo sapiens]                33   0.75 

>gi|62899035 establishment of cohesion 1 homolog 2 [Homo sapiens]
          Length = 601

 Score = 1215 bits (3143), Expect = 0.0
 Identities = 601/601 (100%), Positives = 601/601 (100%)

Query: 1   MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSAL 60
           MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSAL
Sbjct: 1   MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSAL 60

Query: 61  KTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFP 120
           KTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFP
Sbjct: 61  KTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFP 120

Query: 121 IVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN 180
           IVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN
Sbjct: 121 IVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKEN 180

Query: 181 NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEV 240
           NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEV
Sbjct: 181 NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEV 240

Query: 241 IEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHK 300
           IEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHK
Sbjct: 241 IEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHK 300

Query: 301 VDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK 360
           VDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK
Sbjct: 301 VDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQK 360

Query: 361 NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKY 420
           NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKY
Sbjct: 361 NTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKY 420

Query: 421 VGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFL 480
           VGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFL
Sbjct: 421 VGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFL 480

Query: 481 FISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWV 540
           FISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWV
Sbjct: 481 FISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWV 540

Query: 541 FRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFN 600
           FRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFN
Sbjct: 541 FRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFN 600

Query: 601 S 601
           S
Sbjct: 601 S 601


>gi|116235478 establishment of cohesion 1 homolog 1 [Homo sapiens]
          Length = 840

 Score =  311 bits (796), Expect = 1e-84
 Identities = 167/383 (43%), Positives = 237/383 (61%), Gaps = 18/383 (4%)

Query: 232 RTQKSKSEVIEDSDVETVSEKKT--------FATRQVPKCLVLEEKLKIGLLSASSKNKE 283
           + ++  SE ++ +D+     K T         A    P    L+ ++K    SAS+KN  
Sbjct: 454 KMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFS 513

Query: 284 KLIKDSSDDRVSSKEHKVDKNEAFSSEDSL--GENKTISPKSTVYPIFS-ASSVNSKRSL 340
           + ++   ++   S    V       S+  +  GENK        + I S  +S +S    
Sbjct: 514 QCLESKLEN---SPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRE 570

Query: 341 GEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASN 400
                S+   N   +  I K+   ++  K  + QLIIDAGQK FGA  C  CGM+YTASN
Sbjct: 571 TPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASN 630

Query: 401 PEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVD 460
           PEDE QH+  H++F+  +KYVGWKKER++AE+ DG+I++VLP DP +A+KKV++++E+VD
Sbjct: 631 PEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVD 690

Query: 461 NELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPI----GPESPSST 516
           N+LGFQQ    C ++ KT LFIS++K+VVGCLIAE I+  +RV+ E +      E     
Sbjct: 691 NDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRF 750

Query: 517 ECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSD 576
           E  +AW CS +PEPA+CGISRIWVF + RRK+IA R+++ LR+ F++G +LS +EIAFSD
Sbjct: 751 ERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSD 810

Query: 577 PTPDGKLFATKYCNTPNFLVYNF 599
           PTPDGKLFAT+YC T  FLVYNF
Sbjct: 811 PTPDGKLFATQYCGTGQFLVYNF 833


>gi|67551265 transcription factor ELYS [Homo sapiens]
          Length = 2266

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 71/306 (23%), Positives = 128/306 (41%), Gaps = 52/306 (16%)

Query: 110  LKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNR 169
            +K+  ++ S  + T KM G+ V  +K  +K  K ++   +  Y  ++ +S+N +  + + 
Sbjct: 1751 VKSAQQEASADVATPKMPGQSV--RKKTRKA-KEISEASENIYSDVRGLSQNQQIPQNSV 1807

Query: 170  VIYKPIVEKENNCHSAENNSNAPRVL-------------SQKIKPQV---TLQGGAAFFV 213
               +   +KE N    EN S+  + L             SQ ++P V   T +      V
Sbjct: 1808 TPRRGRRKKEVNQDILENTSSVEQELQITTGRESKRLKSSQLLEPAVEETTKKEVKVSSV 1867

Query: 214  RKKSSLR-KSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKI 272
             K++  R K S+EN+ S+        E+I D  V TV    T  +R +        KL+ 
Sbjct: 1868 TKRTPRRIKRSVENQESV--------EIINDLKVSTV----TSPSRMI-------RKLRS 1908

Query: 273  GLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSAS 332
              L AS     K    SSD ++  K  +  +    S  D   ++   S + TV   F  S
Sbjct: 1909 TNLDASENTGNKQDDKSSDKQLRIKHVRRVRGREVSPSDVREDSNLESSQLTVQAEFDMS 1968

Query: 333  SVNSKRSLGEE---QFSVGSVNFMKQTNIQK-------NTNTRDTSKKTKDQLIIDAGQK 382
            ++  KR    +      VGS    ++ + +K         +TR+T  K+++   +D G+ 
Sbjct: 1969 AIPRKRGRPRKINPSEDVGSKAVKEERSPKKKEAPSIRRRSTRNTPAKSEN---VDVGKP 2025

Query: 383  HFGATV 388
              G ++
Sbjct: 2026 ALGKSI 2031


>gi|95147342 chromodomain helicase DNA binding protein 9 [Homo
           sapiens]
          Length = 2881

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 41/171 (23%)

Query: 126 MQGKPVCSKKNNKKPQ----KSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENN 181
           +Q +P  SKK++        ++   +   + +  K V   S+  K NR+I + I + +  
Sbjct: 481 LQRQPPSSKKSDGSGTYTKLQNTQVRVMSEKKQRKKVESESKQEKANRIISEAIAKAKER 540

Query: 182 CHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVI 241
                   N PRV+S +  P  +++G                   E   GR  KSK +  
Sbjct: 541 -----GERNIPRVMSPENFPTASVEG------------------KEEKKGRRMKSKPK-- 575

Query: 242 EDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDD 292
            D D           +++   C  L+EK KIG L  +   K+K   +SSD+
Sbjct: 576 -DKD-----------SKKTKTCSKLKEKTKIGKLIITLGKKQKRKNESSDE 614


>gi|90669307 cyclin B3 isoform 3 [Homo sapiens]
          Length = 1395

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 53/235 (22%), Positives = 97/235 (41%), Gaps = 29/235 (12%)

Query: 151 KYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAA 210
           K   +KP+      S +  +I KP+  KE      E+ S  P  L +K   Q  +     
Sbjct: 394 KRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVS---- 449

Query: 211 FFVRKKSSLRKSSLENEP---SLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLE 267
             +++ SSL KS  E  P   +L  T+K   E       E    KK    ++        
Sbjct: 450 -ILKEPSSLLKSPTEESPFDEALAFTKKCTIE-------EAPPTKKPLILKRKHATQGTM 501

Query: 268 EKLKIGLLSASSKNKEKLIKDS---SDDRVSSKEHKVDKN------EAFSSEDSLGENKT 318
             LK  L+  ++  ++ LIK+     +++VS K+    +       E    +D +GE+K 
Sbjct: 502 SHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKN 561

Query: 319 ---ISPKSTVYPIFSASSVNSKRSLG--EEQFSVGSVNFMKQTNIQKNTNTRDTS 368
              + P S      +  +V +K SL   E++ + G ++ +K+  + +   + + S
Sbjct: 562 SFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEES 616



 Score = 36.6 bits (83), Expect = 0.068
 Identities = 54/252 (21%), Positives = 104/252 (41%), Gaps = 31/252 (12%)

Query: 102 IKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKN-NKKPQKSLTAKYQPKYRHIKPVSR 160
           ++ES S+      +  +F  +T   Q +PV  KK  NK+  K ++ K       +    +
Sbjct: 46  LQESPSSLQGALKKRSAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKK 105

Query: 161 NSRNSKQNR---------------VIYKPIVEKENNCHSAENNSNAPRVLSQK---IKPQ 202
           N RN K ++               ++ KP++   +      N   A   L +K   +K +
Sbjct: 106 NKRNLKWHKLEVTPVVASTTVVPNIMEKPLILDISTTSKTPNTEEAS--LFRKPLVLKEE 163

Query: 203 VTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSD---VETVSEKKTFATRQ 259
            T++      + K  SL+K S   E SL    +   E  +  D   +E ++ KKT  T +
Sbjct: 164 PTIEDET--LINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEE 221

Query: 260 ---VPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGEN 316
                K L L++K+       S + +   ++D + +  S     +   +   +E+S+  +
Sbjct: 222 AAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTH 281

Query: 317 K--TISPKSTVY 326
           K  ++  K T+Y
Sbjct: 282 KLSSLKKKCTIY 293


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 37.0 bits (84), Expect = 0.052
 Identities = 44/175 (25%), Positives = 77/175 (44%), Gaps = 20/175 (11%)

Query: 215  KKSSLRKSSLENEPSLGRTQKS--KSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKI 272
            K  S   S LE + S    +KS  K++  E S  +   ++KT +  +  +  + EE++K 
Sbjct: 1411 KLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIK- 1469

Query: 273  GLLSASSKNKEKLIKDSSDDRVSSKEHK---------VDKNEAFSS--EDSLGENKTISP 321
                +  + K+   KDS  D  SSK+HK           + E + S  E S  EN  +  
Sbjct: 1470 ---ESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQ 1526

Query: 322  KSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLI 376
            +     + S+SS   K+   + Q S    +F+++  I+ + +  D S    D+ I
Sbjct: 1527 RKRRTSVGSSSSDEYKQE--DSQGSGEEEDFIRKQIIEMSAD-EDASGSEDDEFI 1578


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 37.0 bits (84), Expect = 0.052
 Identities = 44/175 (25%), Positives = 77/175 (44%), Gaps = 20/175 (11%)

Query: 215  KKSSLRKSSLENEPSLGRTQKS--KSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKI 272
            K  S   S LE + S    +KS  K++  E S  +   ++KT +  +  +  + EE++K 
Sbjct: 1411 KLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIK- 1469

Query: 273  GLLSASSKNKEKLIKDSSDDRVSSKEHK---------VDKNEAFSS--EDSLGENKTISP 321
                +  + K+   KDS  D  SSK+HK           + E + S  E S  EN  +  
Sbjct: 1470 ---ESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQ 1526

Query: 322  KSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLI 376
            +     + S+SS   K+   + Q S    +F+++  I+ + +  D S    D+ I
Sbjct: 1527 RKRRTSVGSSSSDEYKQE--DSQGSGEEEDFIRKQIIEMSAD-EDASGSEDDEFI 1578


>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
          Length = 3117

 Score = 37.0 bits (84), Expect = 0.052
 Identities = 41/188 (21%), Positives = 75/188 (39%), Gaps = 19/188 (10%)

Query: 88  NQNKWYLNPLERKLIKESRST--CLKTNDEDKSFPIVTEKMQ---GKPVCSKKNNKKPQK 142
           +Q K  L  +E KL     ST  C    D  KS    T K+    G+ +     N    K
Sbjct: 35  SQTKAALRHIENKLEVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNAPISK 94

Query: 143 SLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQ----- 197
           S  ++ +     ++  +  S   K NRV ++  +      H A +N ++  + S+     
Sbjct: 95  STKSRKEKSRSPLRATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCV 154

Query: 198 KIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFAT 257
            +  + T  G      R++ ++R    E+         S+S VI D+ V  ++++     
Sbjct: 155 DVNEEKTESGNWMIGSREERNIRSCDFES---------SQSSVINDTVVRFLNDRPAIDA 205

Query: 258 RQVPKCLV 265
            Q  +CL+
Sbjct: 206 LQNSECLI 213


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 36.6 bits (83), Expect = 0.068
 Identities = 83/362 (22%), Positives = 134/362 (37%), Gaps = 54/362 (14%)

Query: 28  PSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFY 87
           P+P+K        +  ++N+     EHF L  L  TE    P +  GS        V   
Sbjct: 677 PAPSKA---LSGPEPAKDNVEDRTPEHFALVPL--TESQGPPHSGSGSRTSGCRQAVVVQ 731

Query: 88  NQNKWYLNPL---ERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSL 144
             ++    PL   + KL+   R T      +     I  + +   P    K ++  Q+  
Sbjct: 732 EDSRKDRLPLPLRDTKLLSPLRDT---PPPQSLMVKITLDLLSRIPQPPGKGSR--QRKA 786

Query: 145 TAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVT 204
             K  P  +      R+S +S  +++  K   E E +C       N    L ++IK Q +
Sbjct: 787 EDKQPPAGKKHSSEKRSSDSS--SKLAKKRKGEAERDC------DNKKIRLEKEIKSQSS 838

Query: 205 LQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCL 264
                       SS  K S + +PS   +Q SK E++    V + S+K         K  
Sbjct: 839 ----------SSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA-------KPA 881

Query: 265 VLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVD-KNEAFSSEDSLGENKTISPKS 323
           +   + +               K +  D    K+ +V+ K    SSE       T +P  
Sbjct: 882 LKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANP-- 939

Query: 324 TVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSK-KTKDQLIIDAGQK 382
             +P+ S  + NSK   G+ Q     V F KQ   Q + + R+  K K K +L+ D   K
Sbjct: 940 --FPVPSLPNGNSKP--GKPQ-----VKFDKQ---QADLHMREAKKMKQKAELMTDRVGK 987

Query: 383 HF 384
            F
Sbjct: 988 AF 989


>gi|110815815 centlein isoform 1 [Homo sapiens]
          Length = 1406

 Score = 36.2 bits (82), Expect = 0.089
 Identities = 68/374 (18%), Positives = 144/374 (38%), Gaps = 59/374 (15%)

Query: 8   KRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINR 67
           + K+ S +C  LL+  E L                 ++  H  ++++   + +KT E N 
Sbjct: 246 ENKKLSTRCTDLLNDLEKL----------------RKQEAHLRKEKYSTDAKIKTFEDNL 289

Query: 68  LPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQ 127
           + +  +    +S  + +S    NK      + +LI++           D    +V +++Q
Sbjct: 290 IEARKEVEVSQSKYNALSLQLSNK------QTELIQK-----------DMDITLVRKELQ 332

Query: 128 GKPVCSKKNNKKP--QKSLTAKYQPKYRHIKPVSRNSRN-SKQNRVIYKPIVEKENNCHS 184
                 K+N+     Q  L  + Q      + V RN  +      + Y+ +  + + C  
Sbjct: 333 ELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFE 392

Query: 185 AENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDS 244
              ++ A       ++  VT          ++++  K  L+           +S+    +
Sbjct: 393 TTKSNEA------MLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSA 446

Query: 245 DVE---TVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKV 301
            V    ++S  +T    Q  +   L+EKLKI          EKL ++ S ++  S++  +
Sbjct: 447 QVPHRPSLSSLETLMVSQKSEIEYLQEKLKIA--------NEKLSENISANKGFSRKSIM 498

Query: 302 DKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKN 361
              E    E  +  ++++SPKS      S +     + L + +  + ++    Q   Q+N
Sbjct: 499 TSAEGKHKEPPVKRSRSLSPKS------SFTDSEELQKLRKAERKIENLEKALQLKSQEN 552

Query: 362 TNTRDTSKKTKDQL 375
              RD  +K K++L
Sbjct: 553 DELRDAHEKRKERL 566


>gi|223555917 metadherin [Homo sapiens]
          Length = 582

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 49/204 (24%), Positives = 78/204 (38%), Gaps = 29/204 (14%)

Query: 79  SALSTVSFYNQNKWYLNPLER--KLIKESRSTCLKTN----DEDKSFPIVTEKMQGKPVC 132
           S L+ +S  + N  +  P E     + E R++ LK+     D+ K      EK +G    
Sbjct: 380 SGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPT 439

Query: 133 SKKNNKKPQKSL----------TAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNC 182
            K   KK +K            T + + + R   PV+ +    KQ +      +   +  
Sbjct: 440 GKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPA 499

Query: 183 HSAENNSNAPRVL--SQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEV 240
                NS   + L  +   +P V L          KS   KSS +  P L  T KSKS  
Sbjct: 500 EVLVKNSQPIKTLPPATSTEPSVILS---------KSDSDKSSSQVPPILQETDKSKSNT 550

Query: 241 IEDS--DVETVSEKKTFATRQVPK 262
            ++S    +T SE    + +Q+ K
Sbjct: 551 KQNSVPPSQTKSETSWESPKQIKK 574


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 49/225 (21%), Positives = 81/225 (36%), Gaps = 45/225 (20%)

Query: 134 KKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHS--------- 184
           K  N +PQK+ TA  + +Y   +   ++      ++ + K    KE   +S         
Sbjct: 330 KAKNPEPQKA-TAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEV 388

Query: 185 ---AENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKS-------SLENEPSLGRTQ 234
               +NN+ AP+  S +I    + +  A+  V     LR S       S   EPS  + Q
Sbjct: 389 KSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQ 448

Query: 235 KSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRV 294
           K K++V +    ET   +  F  R    C                         SS+   
Sbjct: 449 KEKNKVKKKRKKETKGREVRFGKRSDKFC-------------------------SSESES 483

Query: 295 SSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRS 339
            S E   D  ++  S   L  +  +    +++   SASS +S  S
Sbjct: 484 ESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGS 528



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 27/108 (25%), Positives = 50/108 (46%), Gaps = 20/108 (18%)

Query: 214 RKKSSLRKSSLE-------NEPSLGRTQKSKSEVI----EDSDVETVSEKKTFATRQVPK 262
           +K+  L K  LE       +E SL R + +  ++     E+ D    +EK+     + PK
Sbjct: 695 KKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPK 754

Query: 263 CLVLEEKLKIGLLSASSKNKEKLIK-----DSSDDRVSSKEHKVDKNE 305
               EEKL++       K+K++  K     D  +D++S ++ K+ K +
Sbjct: 755 ----EEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKED 798


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 35.0 bits (79), Expect = 0.20
 Identities = 72/349 (20%), Positives = 131/349 (37%), Gaps = 47/349 (13%)

Query: 32    KKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNK 91
             K+  +Y++  K +EN H   Q H+        +IN L  ++QG               N 
Sbjct: 32747 KEVTWYKDGKKLKENGHF--QFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 32804

Query: 92    WYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPK 151
              ++                      ++F  + EK+       K + K  + ++T K +PK
Sbjct: 32805 QFMG---------------------QAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPK 32843

Query: 152   YRHIKPVSRNSR--NSKQNRVIYKPIVEKENNCHSAENNSNA-----PRVLSQKIKPQVT 204
                 +P+S         Q+  +    V K     + E    A      + ++Q  K +++
Sbjct: 32844 AP--EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS 32901

Query: 205   LQGGAAFFVRKKSSLRKSSL------ENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATR 258
                G  F    K+    S L       +  S+  + K   + I+D++ + VS +KT    
Sbjct: 32902 EDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEIT 32961

Query: 259   QVPKCLVLEEKLKIGLLS-----ASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSL 313
                K +V EE  +  L S     + +K++EKL       +V   E +V K+ A S E S+
Sbjct: 32962 PQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISE-EVKKSAATSLEKSI 33020

Query: 314   GE---NKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQ 359
                   KT      V       + +++ S+ E Q  V   N    T+++
Sbjct: 33021 VHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVK 33069


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score = 35.0 bits (79), Expect = 0.20
 Identities = 72/349 (20%), Positives = 131/349 (37%), Gaps = 47/349 (13%)

Query: 32    KKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNK 91
             K+  +Y++  K +EN H   Q H+        +IN L  ++QG               N 
Sbjct: 26442 KEVTWYKDGKKLKENGHF--QFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 26499

Query: 92    WYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPK 151
              ++                      ++F  + EK+       K + K  + ++T K +PK
Sbjct: 26500 QFMG---------------------QAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPK 26538

Query: 152   YRHIKPVSRNSR--NSKQNRVIYKPIVEKENNCHSAENNSNA-----PRVLSQKIKPQVT 204
                 +P+S         Q+  +    V K     + E    A      + ++Q  K +++
Sbjct: 26539 AP--EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS 26596

Query: 205   LQGGAAFFVRKKSSLRKSSL------ENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATR 258
                G  F    K+    S L       +  S+  + K   + I+D++ + VS +KT    
Sbjct: 26597 EDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEIT 26656

Query: 259   QVPKCLVLEEKLKIGLLS-----ASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSL 313
                K +V EE  +  L S     + +K++EKL       +V   E +V K+ A S E S+
Sbjct: 26657 PQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISE-EVKKSAATSLEKSI 26715

Query: 314   GE---NKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQ 359
                   KT      V       + +++ S+ E Q  V   N    T+++
Sbjct: 26716 VHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVK 26764


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score = 35.0 bits (79), Expect = 0.20
 Identities = 72/349 (20%), Positives = 131/349 (37%), Gaps = 47/349 (13%)

Query: 32    KKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNK 91
             K+  +Y++  K +EN H   Q H+        +IN L  ++QG               N 
Sbjct: 26375 KEVTWYKDGKKLKENGHF--QFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 26432

Query: 92    WYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPK 151
              ++                      ++F  + EK+       K + K  + ++T K +PK
Sbjct: 26433 QFMG---------------------QAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPK 26471

Query: 152   YRHIKPVSRNSR--NSKQNRVIYKPIVEKENNCHSAENNSNA-----PRVLSQKIKPQVT 204
                 +P+S         Q+  +    V K     + E    A      + ++Q  K +++
Sbjct: 26472 AP--EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS 26529

Query: 205   LQGGAAFFVRKKSSLRKSSL------ENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATR 258
                G  F    K+    S L       +  S+  + K   + I+D++ + VS +KT    
Sbjct: 26530 EDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEIT 26589

Query: 259   QVPKCLVLEEKLKIGLLS-----ASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSL 313
                K +V EE  +  L S     + +K++EKL       +V   E +V K+ A S E S+
Sbjct: 26590 PQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISE-EVKKSAATSLEKSI 26648

Query: 314   GE---NKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQ 359
                   KT      V       + +++ S+ E Q  V   N    T+++
Sbjct: 26649 VHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVK 26697


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score = 35.0 bits (79), Expect = 0.20
 Identities = 72/349 (20%), Positives = 131/349 (37%), Gaps = 47/349 (13%)

Query: 32    KKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNK 91
             K+  +Y++  K +EN H   Q H+        +IN L  ++QG               N 
Sbjct: 26250 KEVTWYKDGKKLKENGHF--QFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 26307

Query: 92    WYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPK 151
              ++                      ++F  + EK+       K + K  + ++T K +PK
Sbjct: 26308 QFMG---------------------QAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPK 26346

Query: 152   YRHIKPVSRNSR--NSKQNRVIYKPIVEKENNCHSAENNSNA-----PRVLSQKIKPQVT 204
                 +P+S         Q+  +    V K     + E    A      + ++Q  K +++
Sbjct: 26347 AP--EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS 26404

Query: 205   LQGGAAFFVRKKSSLRKSSL------ENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATR 258
                G  F    K+    S L       +  S+  + K   + I+D++ + VS +KT    
Sbjct: 26405 EDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEIT 26464

Query: 259   QVPKCLVLEEKLKIGLLS-----ASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSL 313
                K +V EE  +  L S     + +K++EKL       +V   E +V K+ A S E S+
Sbjct: 26465 PQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISE-EVKKSAATSLEKSI 26523

Query: 314   GE---NKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQ 359
                   KT      V       + +++ S+ E Q  V   N    T+++
Sbjct: 26524 VHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVK 26572


>gi|65507253 hypothetical protein LOC55196 [Homo sapiens]
          Length = 1747

 Score = 35.0 bits (79), Expect = 0.20
 Identities = 37/196 (18%), Positives = 72/196 (36%), Gaps = 4/196 (2%)

Query: 109 CLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQN 168
           C+K  +   S P    K+  K     K    PQ  +T           P    S  + + 
Sbjct: 426 CIKMTNTSYSEPAQNSKLSLKQTA--KIQSGPQ--ITPVMPENAERQTPTVVESAETNKT 481

Query: 169 RVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEP 228
           + +    +++ N     + +S  P  +  + +P             K S++  +      
Sbjct: 482 QCMLNSDIQEVNCRRFNQVDSVLPNPVYSEKRPMPDPSHDVKVLTSKTSAVEMTQAVLNT 541

Query: 229 SLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKD 288
            L     +K E    +  ET+S  K+ +T +    +  E  L + LLS + K ++ ++KD
Sbjct: 542 QLSSENVTKVEQNSPAVCETISVPKSMSTEEYKSKIQNENMLLLALLSQARKTQKTVLKD 601

Query: 289 SSDDRVSSKEHKVDKN 304
           ++     SK    + N
Sbjct: 602 ANQTIQDSKPDSCEMN 617


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score = 34.7 bits (78), Expect = 0.26
 Identities = 60/279 (21%), Positives = 112/279 (40%), Gaps = 48/279 (17%)

Query: 41   DKNEENLHCSQQEHFVLSALKTTEINRL---------PSANQGSPFKSALSTVSFYNQNK 91
            D+  ENL   Q++   +  L+    NRL             + S F++ L      N+ K
Sbjct: 875  DQEIENLEKQQKQ--TIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLK-----NRKK 927

Query: 92   WYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPK 151
              +N +E K  KE R   +K   E+    +   +   +    +K  ++   SL    Q +
Sbjct: 928  EVINEVE-KAPKELRKELMKRRKEE----LAQSQHAQEQEFVQKQQQELDGSLKKIIQQQ 982

Query: 152  YRHIKPVSRNSRNSKQN--RVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGA 209
               +  + R   N+KQ   R     I E E   H  E +    ++L Q++K Q       
Sbjct: 983  KAELANIERECLNNKQQLMRAREAAIWELEER-HLQEKH----QLLKQQLKDQ------- 1030

Query: 210  AFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEK 269
             +F+++   L++   E E    + Q+    +IE+     +  ++T    ++PK    E K
Sbjct: 1031 -YFMQRHQLLKRHEKETE----QMQRYNQRLIEE-----LKNRQTQERARLPKIQRSEAK 1080

Query: 270  LKIGLLSASSKNKEKLIKDSSDDRV---SSKEHKVDKNE 305
             ++ +   S +       D   D++   +++E K  KNE
Sbjct: 1081 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNE 1119


>gi|215982794 myosin VA isoform 2 [Homo sapiens]
          Length = 1828

 Score = 34.3 bits (77), Expect = 0.34
 Identities = 48/218 (22%), Positives = 90/218 (41%), Gaps = 23/218 (10%)

Query: 122  VTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENN 181
            VTE  Q K V   + ++K ++ L +K + + R   P  R +    ++  + +  +E EN 
Sbjct: 1162 VTELEQEKQVMQDELDRKEEQVLRSKAKEEER---PQIRGAELEYES--LKRQELESENK 1216

Query: 182  CHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSS----LENEPSLGRTQ-KS 236
                E N    + LS+K  P+VT  G  A+ V  +     S      + E  + R+Q  S
Sbjct: 1217 KLKNELNE-LRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLILRSQLVS 1275

Query: 237  KSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSS 296
            + E I+  D +      T     V K   +++K +I       K   +L++     +  S
Sbjct: 1276 QKEAIQPKDDKNTMTDSTILLEDVQK---MKDKGEIAQAYIGLKETNRLLESQLQSQKRS 1332

Query: 297  KEHKVD---------KNEAFSSEDSLGENKTISPKSTV 325
             E++ +         K E    +  L +N  + P++ +
Sbjct: 1333 HENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARI 1370


>gi|34996489 pleckstrin homology domain interacting protein [Homo
            sapiens]
          Length = 1821

 Score = 34.3 bits (77), Expect = 0.34
 Identities = 71/323 (21%), Positives = 130/323 (40%), Gaps = 45/323 (13%)

Query: 75   SPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSK 134
            S +KSAL    F+ +N   +    +K  + S  +    +  ++   I+  K Q K   S 
Sbjct: 1423 SDYKSALR---FHKRNT--ITKRRKKRNRSSSVSSSAASSPERKKRIL--KPQLKSESST 1475

Query: 135  KNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSA-------EN 187
                 P +S+  ++     + K  S +   ++ NRV+  P+V ++ +  SA        N
Sbjct: 1476 SAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKAN 1535

Query: 188  NSNAP--RVLSQKIKPQVTLQ-----GGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEV 240
             S  P   +L   +K    L      G ++F    +++  K ++E E  + R  K KS V
Sbjct: 1536 ASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKENMEKEKPVKR--KMKSSV 1593

Query: 241  IEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKE--KLIKDSSDDRVSSKE 298
            +  +   T+S  K+ A  +   C      L  G +  +    +  KL+K     R   ++
Sbjct: 1594 LPKA--STLS--KSSAVIEQGDC--KNNALVPGTIQVNGHGGQPSKLVK-----RGPGRK 1642

Query: 299  HKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTN- 357
             KV+ N   +S + + + +   PK   Y        N+   + +E     + NF+ +TN 
Sbjct: 1643 PKVEVNT--NSGEIIHKKRGRKPKKLQYAKPEDLEQNNVHPIRDEVLPSSTCNFLSETNN 1700

Query: 358  ------IQKNTNTRDTSKKTKDQ 374
                   +KN   R   +K K Q
Sbjct: 1701 VKEDLLQKKNRGGRKPKRKMKTQ 1723


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score = 34.3 bits (77), Expect = 0.34
 Identities = 31/112 (27%), Positives = 46/112 (41%), Gaps = 17/112 (15%)

Query: 216 KSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLL 275
           KS ++K   +   S   +  S S+    SD ++ S+     +         EEK      
Sbjct: 180 KSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSES-------ATEEK------ 226

Query: 276 SASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYP 327
             S K K+K  K+S   +   K+ K  K  A  S +S  EN    P+STV P
Sbjct: 227 --SKKRKKKHRKNSRKHKKEKKKRKKSKKSA--SSESEAENLEAQPQSTVRP 274


>gi|4826894 phosphodiesterase 1C [Homo sapiens]
          Length = 634

 Score = 33.9 bits (76), Expect = 0.44
 Identities = 26/107 (24%), Positives = 50/107 (46%), Gaps = 11/107 (10%)

Query: 267 EEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVY 326
           EEK +   L+A  + KE   K  +++  S K  K    E  +  +    NK+ +P+    
Sbjct: 536 EEKAR---LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRG--- 589

Query: 327 PIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKD 373
                 +  +++S GE+Q +    +   +T+ + ++N  + SKKT D
Sbjct: 590 -----KNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDD 631


>gi|216548091 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 33.9 bits (76), Expect = 0.44
 Identities = 41/191 (21%), Positives = 84/191 (43%), Gaps = 24/191 (12%)

Query: 142 KSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP 201
           KSLT  +  + +++      +   K+N  + K + +K     + + N +  R  S   + 
Sbjct: 187 KSLTLSFVSERKYL------NEKEKENEKLIKELTQKLEQ--NKKMNRDYTRNASNLERN 238

Query: 202 QVTLQGGAAFFVRKKSSLRKSSL------ENEPSLGRTQKSKSEVIEDSDVETVSEKKTF 255
            + ++ G +  +  K S RK  L      ENE +  +++  K+   ED+ V+ ++++   
Sbjct: 239 DLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKSENEKNRNQEDNKVKDLNQEIEK 297

Query: 256 ATRQVPKCLVLEEKLK--------IGLLSASSKNKEKLIKDSSDD-RVSSKEHKVDKNEA 306
              Q+     LEE+LK        +     S +NK KL+    ++ ++  K+ K  +N  
Sbjct: 298 LKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGE 357

Query: 307 FSSEDSLGENK 317
              ED+   +K
Sbjct: 358 VEGEDAFLSSK 368


>gi|216548085 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 33.9 bits (76), Expect = 0.44
 Identities = 41/191 (21%), Positives = 84/191 (43%), Gaps = 24/191 (12%)

Query: 142 KSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP 201
           KSLT  +  + +++      +   K+N  + K + +K     + + N +  R  S   + 
Sbjct: 187 KSLTLSFVSERKYL------NEKEKENEKLIKELTQKLEQ--NKKMNRDYTRNASNLERN 238

Query: 202 QVTLQGGAAFFVRKKSSLRKSSL------ENEPSLGRTQKSKSEVIEDSDVETVSEKKTF 255
            + ++ G +  +  K S RK  L      ENE +  +++  K+   ED+ V+ ++++   
Sbjct: 239 DLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKSENEKNRNQEDNKVKDLNQEIEK 297

Query: 256 ATRQVPKCLVLEEKLK--------IGLLSASSKNKEKLIKDSSDD-RVSSKEHKVDKNEA 306
              Q+     LEE+LK        +     S +NK KL+    ++ ++  K+ K  +N  
Sbjct: 298 LKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGE 357

Query: 307 FSSEDSLGENK 317
              ED+   +K
Sbjct: 358 VEGEDAFLSSK 368


>gi|187608809 hypothetical protein LOC23240 isoform 2 [Homo sapiens]
          Length = 1609

 Score = 33.9 bits (76), Expect = 0.44
 Identities = 31/150 (20%), Positives = 62/150 (41%), Gaps = 5/150 (3%)

Query: 93   YLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKY 152
            + NP     +KE   TC+   + D      T + + + +C  K +KK  ++   +  P+Y
Sbjct: 1066 FSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQY 1125

Query: 153  RH--IKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAA 210
                +  +SR + N    +V  K  V+   N    +   ++ + + +  +  +  +    
Sbjct: 1126 HQPDLPEISRKN-NGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDI 1184

Query: 211  FFVRKKSSLRKSSLE--NEPSLGRTQKSKS 238
             FV ++   RK  L+   E +L     SKS
Sbjct: 1185 PFVEQEDPYRKKKLQEKREGNLQNLNWSKS 1214


>gi|196114949 hypothetical protein LOC23240 isoform 1 [Homo sapiens]
          Length = 1610

 Score = 33.9 bits (76), Expect = 0.44
 Identities = 31/150 (20%), Positives = 62/150 (41%), Gaps = 5/150 (3%)

Query: 93   YLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKY 152
            + NP     +KE   TC+   + D      T + + + +C  K +KK  ++   +  P+Y
Sbjct: 1067 FSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQY 1126

Query: 153  RH--IKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAA 210
                +  +SR + N    +V  K  V+   N    +   ++ + + +  +  +  +    
Sbjct: 1127 HQPDLPEISRKN-NGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDI 1185

Query: 211  FFVRKKSSLRKSSLE--NEPSLGRTQKSKS 238
             FV ++   RK  L+   E +L     SKS
Sbjct: 1186 PFVEQEDPYRKKKLQEKREGNLQNLNWSKS 1215


>gi|4506325 protein tyrosine phosphatase, receptor type, R isoform 1
           precursor [Homo sapiens]
          Length = 657

 Score = 33.5 bits (75), Expect = 0.58
 Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 109 CLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQN 168
           C   N++   F  + +K  GKPV   K+++  +KSL    Q  YRH    S  ++ SK++
Sbjct: 21  CFSGNNDH--FLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRH 78

Query: 169 RVI 171
           +++
Sbjct: 79  QIV 81


>gi|7549793 transducin (beta)-like 2 [Homo sapiens]
          Length = 447

 Score = 33.5 bits (75), Expect = 0.58
 Identities = 21/97 (21%), Positives = 43/97 (44%), Gaps = 1/97 (1%)

Query: 124 EKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCH 183
           E+  G+P C K N   P KS  +K Q +Y+ I+   +  +++  +R++   +     N  
Sbjct: 36  EERSGRPACQKANGFPPDKSSGSKKQKQYQRIRK-EKPQQHNFTHRLLAAALKSHSGNIS 94

Query: 184 SAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLR 220
             + +SN   + +      + +     F  R+  S+R
Sbjct: 95  CMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMR 131


>gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens]
          Length = 778

 Score = 33.5 bits (75), Expect = 0.58
 Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 51/268 (19%)

Query: 94  LNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYR 153
           L+P+E +  +++        D D++     E+++   +C   + +K    LT  Y+    
Sbjct: 113 LHPMEHEFYEDNEYISSLPADADRTEDFEYEEVE---LCRVSSQEK--LGLTVCYRTDDE 167

Query: 154 -----HIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGG 208
                ++  V  NS  +K  R+     + + N     +N   A  +LS     ++ L   
Sbjct: 168 EDTGIYVSEVDPNSIAAKDGRIREGDRILQING-EDVQNREEAVALLSNDECKRIVL--- 223

Query: 209 AAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATR------QVPK 262
                R +  L +  LE+E         ++E +E+ ++E + E+   A +      + PK
Sbjct: 224 --LVARPEIQLDEGWLEDE---------RNEFLEELNLEMLEEEHNEAMQPTANEVEQPK 272

Query: 263 CLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPK 322
               EE+      ++SS N EK      D  V   +  +  +E  SSE    EN    P 
Sbjct: 273 KQE-EEEGTTDTATSSSNNHEK------DSGVGRTDESLRNDE--SSEQ---ENAAEDPN 320

Query: 323 STVYPIFSASSVNSKRSLGEEQFSVGSV 350
           ST        S+ SKR LG+ Q ++GSV
Sbjct: 321 ST--------SLKSKRDLGQSQDTLGSV 340


>gi|40068059 CBF1 interacting corepressor [Homo sapiens]
          Length = 450

 Score = 33.1 bits (74), Expect = 0.75
 Identities = 38/157 (24%), Positives = 69/157 (43%), Gaps = 23/157 (14%)

Query: 181 NCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEV 240
           N  S   + + P +   ++  ++   G    F  K++ L ++   N+PS    +   SE 
Sbjct: 152 NASSVPTDGSGPSMHPSELIAEMRNSG----FALKRNVLGRNLTANDPS---QEYVASEG 204

Query: 241 IEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHK 300
            ED +VE +   K+  T+Q  K L   ++L+        K K+K  +     + S  +HK
Sbjct: 205 EEDPEVEFL---KSLTTKQKQKLLRKLDRLE--------KKKKKKDRKKKKFQKSRSKHK 253

Query: 301 VDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSK 337
             K+ + SS  S   + T + +S+     S S  N+K
Sbjct: 254 KHKSSSSSSSSSSSSSSTETSESS-----SESESNNK 285


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,172,070
Number of Sequences: 37866
Number of extensions: 1056622
Number of successful extensions: 2947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 2855
Number of HSP's gapped (non-prelim): 214
length of query: 601
length of database: 18,247,518
effective HSP length: 108
effective length of query: 493
effective length of database: 14,157,990
effective search space: 6979889070
effective search space used: 6979889070
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.