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Search of human proteins with 62865643
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
(275 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 561 e-160
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 561 e-160
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 561 e-160
gi|83776600 aurora kinase B [Homo sapiens] 476 e-135
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 396 e-111
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 396 e-111
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 396 e-111
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 396 e-111
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 396 e-111
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 396 e-111
gi|121114283 polo-like kinase 4 [Homo sapiens] 182 3e-46
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 178 5e-45
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 174 1e-43
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 174 1e-43
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 174 1e-43
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 174 1e-43
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 173 1e-43
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 171 5e-43
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 171 6e-43
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 171 8e-43
gi|116256471 SNF1-like kinase [Homo sapiens] 169 2e-42
gi|28557781 protein kinase C, eta [Homo sapiens] 169 3e-42
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 165 3e-41
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 165 3e-41
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 165 3e-41
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 165 3e-41
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 165 3e-41
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 165 5e-41
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 164 6e-41
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 164 6e-41
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 561 bits (1446), Expect = e-160
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 1 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 60
MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI
Sbjct: 1 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 60
Query: 61 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120
QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL
Sbjct: 61 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120
Query: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 180
TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 180
Query: 181 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 240
TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL
Sbjct: 181 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 240
Query: 241 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 275
RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 241 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 275
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 561 bits (1446), Expect = e-160
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 1 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 60
MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI
Sbjct: 16 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 75
Query: 61 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120
QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL
Sbjct: 76 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 135
Query: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 180
TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 136 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 195
Query: 181 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 240
TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL
Sbjct: 196 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 255
Query: 241 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 275
RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 256 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 290
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 561 bits (1446), Expect = e-160
Identities = 275/275 (100%), Positives = 275/275 (100%)
Query: 1 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 60
MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI
Sbjct: 35 MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 94
Query: 61 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120
QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL
Sbjct: 95 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 154
Query: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 180
TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 155 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 214
Query: 181 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 240
TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL
Sbjct: 215 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 274
Query: 241 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 275
RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 275 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 309
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 476 bits (1225), Expect = e-135
Identities = 228/270 (84%), Positives = 250/270 (92%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
R T+DDFEIGRPLGKGKFGNVYLAR K+SHFIVALKVLFKSQIEKEG+EHQLRREIEIQ
Sbjct: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
AHL HPNILRLYNYF+D RR+YLILEYAPRGELYKELQKS DEQRTATI+EELADAL
Sbjct: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
YCH KKVIHRDIKPENLLLG +GE+KIADFGWSVH PSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
Query: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
++EKVDLWCIGVLCYELLVG PPFESASH+ETYRRI+KVD++FP S+P+GA+DLIS+LLR
Sbjct: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
Query: 242 YQPLERLPLAQILKHPWVQAHSRRVLPPCA 271
+ P ERLPLAQ+ HPWV+A+SRRVLPP A
Sbjct: 310 HNPSERLPLAQVSAHPWVRANSRRVLPPSA 339
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 396 bits (1018), Expect = e-111
Identities = 188/264 (71%), Positives = 224/264 (84%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K DEQRTAT I ELA+AL+
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR T+CGTLDYLPPEMIEGR
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
+DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP + GARDLISRLL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 242 YQPLERLPLAQILKHPWVQAHSRR 265
+ P +R L ++L+HPW+ A+S +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 396 bits (1018), Expect = e-111
Identities = 188/264 (71%), Positives = 224/264 (84%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K DEQRTAT I ELA+AL+
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR T+CGTLDYLPPEMIEGR
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
+DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP + GARDLISRLL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 242 YQPLERLPLAQILKHPWVQAHSRR 265
+ P +R L ++L+HPW+ A+S +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 396 bits (1018), Expect = e-111
Identities = 188/264 (71%), Positives = 224/264 (84%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K DEQRTAT I ELA+AL+
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR T+CGTLDYLPPEMIEGR
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
+DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP + GARDLISRLL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 242 YQPLERLPLAQILKHPWVQAHSRR 265
+ P +R L ++L+HPW+ A+S +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 396 bits (1018), Expect = e-111
Identities = 188/264 (71%), Positives = 224/264 (84%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K DEQRTAT I ELA+AL+
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR T+CGTLDYLPPEMIEGR
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
+DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP + GARDLISRLL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 242 YQPLERLPLAQILKHPWVQAHSRR 265
+ P +R L ++L+HPW+ A+S +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 396 bits (1018), Expect = e-111
Identities = 188/264 (71%), Positives = 224/264 (84%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K DEQRTAT I ELA+AL+
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR T+CGTLDYLPPEMIEGR
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
+DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP + GARDLISRLL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 242 YQPLERLPLAQILKHPWVQAHSRR 265
+ P +R L ++L+HPW+ A+S +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 396 bits (1018), Expect = e-111
Identities = 188/264 (71%), Positives = 224/264 (84%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
R+ ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK K DEQRTAT I ELA+AL+
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
YCH K+VIHRDIKPENLLLG GE+KIADFGWSVH PS RR T+CGTLDYLPPEMIEGR
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
+DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP + GARDLISRLL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 242 YQPLERLPLAQILKHPWVQAHSRR 265
+ P +R L ++L+HPW+ A+S +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 182 bits (462), Expect = 3e-46
Identities = 91/261 (34%), Positives = 150/261 (57%), Gaps = 3/261 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
++DF++G LGKG F VY A + VA+K++ K + K G+ +++ E++I L+
Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK-LDEQRTATIIEELADALTYCH 124
HP+IL LYNYF D+ VYL+LE GE+ + L+ K E + ++ + Y H
Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
Query: 125 DKKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTY 182
++HRD+ NLLL +KIADFG + + P + T+CGT +Y+ PE+ +
Sbjct: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
Query: 183 DEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRY 242
+ D+W +G + Y LL+G PPF++ + T +++ D P + + A+DLI +LLR
Sbjct: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
Query: 243 QPLERLPLAQILKHPWVQAHS 263
P +RL L+ +L HP++ +S
Sbjct: 249 NPADRLSLSSVLDHPFMSRNS 269
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 178 bits (451), Expect = 5e-45
Identities = 98/272 (36%), Positives = 154/272 (56%), Gaps = 8/272 (2%)
Query: 9 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 68
+EI R +GKG F V A + VA+K++ K+Q+++E L+ ++ RE++I L HP+
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPH 66
Query: 69 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 128
I+RLY R +YL+ EYA GE++ L ++ E+ +++ A+ +CH + +
Sbjct: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
Query: 129 IHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD-EKV 186
+HRD+K ENLLL +KIADFG+S + TP KT CG+ Y PE+ EG+ YD KV
Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186
Query: 187 DLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLE 246
D+W +GV+ Y L+ G PF+ ++ R+L R P M LI +L P +
Sbjct: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246
Query: 247 RLPLAQILKHPWVQ-----AHSRRVLPPCAQM 273
RL + QI KH W++ + R++ C Q+
Sbjct: 247 RLSMEQICKHKWMKLGDADPNFDRLIAECQQL 278
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 244 PLERLPLAQILKHPWVQA-HSRRVLPP 269
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 244 PLERLPLAQILKHPWVQA-HSRRVLPP 269
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 244 PLERLPLAQILKHPWVQA-HSRRVLPP 269
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 174 bits (440), Expect = 1e-43
Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YLI+EYA GE++ L ++ E+ + ++ A+ YCH
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K+++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ R L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
Query: 244 PLERLPLAQILKHPWVQA-HSRRVLPP 269
P++R L QI+K W+ A H L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 173 bits (439), Expect = 1e-43
Identities = 91/256 (35%), Positives = 143/256 (55%), Gaps = 3/256 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
V ++ + R +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLFREVRIMKGLN 114
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 115 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 174
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 175 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M ++ R L
Sbjct: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294
Query: 244 PLERLPLAQILKHPWV 259
P +R L QI+K W+
Sbjct: 295 PAKRCTLEQIMKDKWI 310
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 171 bits (434), Expect = 5e-43
Identities = 95/266 (35%), Positives = 153/266 (57%), Gaps = 4/266 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
++ + + +G+G FG VY R K S +VALK + K ++ L + L+REIEI L+
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLR 59
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI+ + + F + V ++ +YA GEL++ L+ KL E + I +L AL Y H
Sbjct: 60 HPNIVHMLDSFETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTYD 183
+++HRD+KP+N+LL G +K+ DFG++ + T ++ ++ GT Y+ PE++E R YD
Sbjct: 119 HRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD 178
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
DLW +G + YEL VG PPF + S + ILK VR+P ++ ++ + LL
Sbjct: 179 HTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKD 238
Query: 244 PLERLPLAQILKHPWVQAHSRRVLPP 269
P +RL +L HP++ H + P
Sbjct: 239 PRQRLSWPDLLYHPFIAGHVTIITEP 264
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 171 bits (433), Expect = 6e-43
Identities = 93/267 (34%), Positives = 149/267 (55%), Gaps = 4/267 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRIMKILN 115
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 176 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ +LL
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295
Query: 244 PLERLPLAQILKHPWVQ-AHSRRVLPP 269
P++R L QI+K W+ H L P
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEEEELKP 322
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 171 bits (432), Expect = 8e-43
Identities = 95/253 (37%), Positives = 141/253 (55%), Gaps = 3/253 (1%)
Query: 9 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 68
+E+ LGKG +G V A + S +VA+K + K +I+ E +RREIEI + L HP+
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 69 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 128
I+ +Y F + ++ +I+EYA +GELY + + +L E+ T ++ A+ YCH V
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 129 IHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTY-DEKV 186
+HRD+K EN+LL +KIADFG S ++ +T CG+ Y PE++ GR Y +V
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 187 DLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLE 246
D W +GVL Y L+ G PF+ H R+I + R P + P AR LI +L P
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
Query: 247 RLPLAQILKHPWV 259
R + I H WV
Sbjct: 294 RATIEDIANHWWV 306
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 169 bits (429), Expect = 2e-42
Identities = 91/269 (33%), Positives = 150/269 (55%), Gaps = 3/269 (1%)
Query: 4 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 63
L V ++I R LGKG F V LAR + + VA+K++ K++++ LE ++ RE+++
Sbjct: 22 LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80
Query: 64 LQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYC 123
L HP+I++LY +Y++ E+A GE++ L + L E ++ A+ YC
Sbjct: 81 LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140
Query: 124 HDKKVIHRDIKPENLLLGFRGEVKIADFGW-SVHTPSLRRKTMCGTLDYLPPEMIEGRTY 182
HD ++HRD+K ENLLL ++K+ADFG+ + + T CG+ Y PE+ EG+ Y
Sbjct: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200
Query: 183 D-EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
+ ++D+W +GV+ Y L+ G PF+ + +R+L+ R P M LI R+L
Sbjct: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260
Query: 242 YQPLERLPLAQILKHPWVQAHSRRVLPPC 270
P R+ +AQI +H W++A P C
Sbjct: 261 VDPARRITIAQIRQHRWMRAEPCLPGPAC 289
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 169 bits (427), Expect = 3e-42
Identities = 99/282 (35%), Positives = 152/282 (53%), Gaps = 15/282 (5%)
Query: 3 RLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI-EKEGLEHQLRREIEIQ 61
RL +D+FE R LGKG FG V LAR+KE+ + A+KVL K I + + +E + + +
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
Query: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
HP + +L+ F R++ ++E+ G+L +QKS + DE R E+ AL
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468
Query: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVH--TPSLRRKTMCGTLDYLPPEMIEG 179
+ HDK +I+RD+K +N+LL G K+ADFG + T CGT DY+ PE+++
Sbjct: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528
Query: 180 RTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRL 239
Y VD W +GVL YE+L G+ PFE+ + + + IL +V +P + A ++
Sbjct: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSF 588
Query: 240 LRYQPLERL-PLAQ-----ILKHP------WVQAHSRRVLPP 269
+ P RL L Q IL+HP W Q + R++ PP
Sbjct: 589 MTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 165 bits (418), Expect = 3e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 244 PLERLPLAQILKHPWV 259
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 165 bits (418), Expect = 3e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 244 PLERLPLAQILKHPWV 259
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 165 bits (418), Expect = 3e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 244 PLERLPLAQILKHPWV 259
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 165 bits (418), Expect = 3e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288
Query: 244 PLERLPLAQILKHPWV 259
P +R L QI+K W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 165 bits (418), Expect = 3e-41
Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)
Query: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
+ ++ + + +GKG F V LAR + VA+K++ K+Q+ L+ +L RE+ I L
Sbjct: 17 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 75
Query: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 125
HPNI++L+ + +YL++EYA GE++ L ++ E+ ++ A+ YCH
Sbjct: 76 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 135
Query: 126 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 183
K ++HRD+K ENLLL +KIADFG+S T + T CG+ Y PE+ +G+ YD
Sbjct: 136 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
Query: 184 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 243
+VD+W +GV+ Y L+ G PF+ + E R+L+ R P M +L+ + L
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255
Query: 244 PLERLPLAQILKHPWV 259
P +R L QI+K W+
Sbjct: 256 PSKRGTLEQIMKDRWM 271
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 165 bits (417), Expect = 5e-41
Identities = 92/253 (36%), Positives = 143/253 (56%), Gaps = 3/253 (1%)
Query: 9 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 68
++I LGKG F V L R + + VA+K++ KSQ++ LE ++ RE++I L HP+
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE-KIYREVQIMKMLDHPH 78
Query: 69 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 128
I++LY +YL+ EYA GE++ L +L+E ++ A+ YCH +K+
Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
Query: 129 IHRDIKPENLLLGFRGEVKIADFGWSVHTPSLR-RKTMCGTLDYLPPEMIEGRTYD-EKV 186
+HRD+K ENLLL +KIADFG+ S T CG+ Y PE+ EG+ Y+ ++
Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQL 198
Query: 187 DLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLE 246
D+W +GV+ Y L+ G PF+ + +R+L+ R P M LI R+L P +
Sbjct: 199 DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSK 258
Query: 247 RLPLAQILKHPWV 259
RL +AQI +H W+
Sbjct: 259 RLTIAQIKEHKWM 271
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 164 bits (416), Expect = 6e-41
Identities = 98/282 (34%), Positives = 149/282 (52%), Gaps = 15/282 (5%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI-EKEGLEHQLRREIEI 60
+R T++DF+ + LGKG FG V L R K S A+K+L K I K+ + H L E +
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLT-ESRV 199
Query: 61 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120
+ +HP + L F R+ ++EY GEL+ L + E RT E+ AL
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVH--TPSLRRKTMCGTLDYLPPEMIE 178
Y H K+++RD+K ENL+L G +KI DFG T + KT CGT +YL PE++E
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLE 319
Query: 179 GRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISR 238
Y VD W +GV+ YE++ G PF + H + + IL D++FP ++ A+ L+S
Sbjct: 320 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSG 379
Query: 239 LLRYQPLERL-----PLAQILKHP------WVQAHSRRVLPP 269
LL P +RL +I++H W + ++++PP
Sbjct: 380 LLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 164 bits (416), Expect = 6e-41
Identities = 98/282 (34%), Positives = 149/282 (52%), Gaps = 15/282 (5%)
Query: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI-EKEGLEHQLRREIEI 60
+R T++DF+ + LGKG FG V L R K S A+K+L K I K+ + H L E +
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLT-ESRV 199
Query: 61 QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120
+ +HP + L F R+ ++EY GEL+ L + E RT E+ AL
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVH--TPSLRRKTMCGTLDYLPPEMIE 178
Y H K+++RD+K ENL+L G +KI DFG T + KT CGT +YL PE++E
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLE 319
Query: 179 GRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISR 238
Y VD W +GV+ YE++ G PF + H + + IL D++FP ++ A+ L+S
Sbjct: 320 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSG 379
Query: 239 LLRYQPLERL-----PLAQILKHP------WVQAHSRRVLPP 269
LL P +RL +I++H W + ++++PP
Sbjct: 380 LLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.141 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,773,744
Number of Sequences: 37866
Number of extensions: 473663
Number of successful extensions: 3582
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 752
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 976
Number of HSP's gapped (non-prelim): 1012
length of query: 275
length of database: 18,247,518
effective HSP length: 101
effective length of query: 174
effective length of database: 14,423,052
effective search space: 2509611048
effective search space used: 2509611048
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.