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Search of human proteins with 6274552
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6274552 signal transducer and activator of transcription 1
isoform alpha [Homo sapiens]
(750 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6274552 signal transducer and activator of transcription 1 is... 1518 0.0
gi|21536301 signal transducer and activator of transcription 1 i... 1443 0.0
gi|21618340 signal transducer and activator of transcription 3 i... 781 0.0
gi|21618338 signal transducer and activator of transcription 3 i... 780 0.0
gi|47458820 signal transducer and activator of transcription 3 i... 775 0.0
gi|4507255 signal transducer and activator of transcription 4 [H... 757 0.0
gi|4885615 signal transducer and activator of transcription 2 [H... 539 e-153
gi|21618344 signal transducer and activator of transcription 5B ... 298 2e-80
gi|21618342 signal transducer and activator of transcription 5A ... 286 6e-77
gi|23397678 signal transducer and activator of transcription 6 [... 177 2e-44
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 43 0.001
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 43 0.001
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 42 0.002
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 42 0.002
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 42 0.003
gi|122891870 melanoma inhibitory activity family, member 3 [Homo... 41 0.004
gi|21735548 centrosomal protein 2 [Homo sapiens] 41 0.005
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 40 0.006
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 40 0.008
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 40 0.008
gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso... 40 0.010
gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof... 40 0.010
gi|93102364 SWAP-70 protein [Homo sapiens] 39 0.014
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 39 0.014
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 39 0.014
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 39 0.014
gi|217035164 coiled-coil domain containing 27 [Homo sapiens] 39 0.018
gi|118498356 kinectin 1 isoform a [Homo sapiens] 39 0.023
gi|33620775 kinectin 1 isoform a [Homo sapiens] 39 0.023
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 39 0.023
>gi|6274552 signal transducer and activator of transcription 1
isoform alpha [Homo sapiens]
Length = 750
Score = 1518 bits (3929), Expect = 0.0
Identities = 750/750 (100%), Positives = 750/750 (100%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
Sbjct: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
Query: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
Sbjct: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
Query: 121 RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR 180
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
Sbjct: 121 RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR 180
Query: 181 EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK 240
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
Sbjct: 181 EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK 240
Query: 241 RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV 300
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
Sbjct: 241 RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV 300
Query: 301 LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV 360
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
Sbjct: 301 LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV 360
Query: 361 KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN 420
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
Sbjct: 361 KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN 420
Query: 421 EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE 480
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
Sbjct: 421 EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE 480
Query: 481 PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT 540
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
Sbjct: 481 PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT 540
Query: 541 RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL 600
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
Sbjct: 541 RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL 600
Query: 601 LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP 660
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
Sbjct: 601 LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP 660
Query: 661 ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT 720
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
Sbjct: 661 ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT 720
Query: 721 DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV 750
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
Sbjct: 721 DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV 750
>gi|21536301 signal transducer and activator of transcription 1
isoform beta [Homo sapiens]
Length = 712
Score = 1443 bits (3735), Expect = 0.0
Identities = 712/712 (100%), Positives = 712/712 (100%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
Sbjct: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
Query: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
Sbjct: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
Query: 121 RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR 180
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
Sbjct: 121 RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR 180
Query: 181 EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK 240
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
Sbjct: 181 EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK 240
Query: 241 RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV 300
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
Sbjct: 241 RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV 300
Query: 301 LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV 360
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
Sbjct: 301 LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV 360
Query: 361 KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN 420
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
Sbjct: 361 KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN 420
Query: 421 EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE 480
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
Sbjct: 421 EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE 480
Query: 481 PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT 540
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
Sbjct: 481 PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT 540
Query: 541 RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL 600
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
Sbjct: 541 RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL 600
Query: 601 LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP 660
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
Sbjct: 601 LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP 660
Query: 661 ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEV 712
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEV
Sbjct: 661 ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEV 712
>gi|21618340 signal transducer and activator of transcription 3
isoform 1 [Homo sapiens]
Length = 770
Score = 781 bits (2017), Expect = 0.0
Identities = 392/741 (52%), Positives = 537/741 (72%), Gaps = 14/741 (1%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
M+QW +LQQLD+++LEQ+HQLY DSFPME+RQ+LA W+E QDW +AA+ S AT+ FH+L
Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
Query: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
L ++D QYSRF E+N L QHN+R+ K+ LQ + E P++++ I+ CL EE ++L+ A
Sbjct: 61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
Query: 121 RFNQ--AQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQ 178
Q Q+ + + V+ +KQ+ L+ +++V+ +V +E ++K +E+LQD++DF KTL+
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
Query: 179 NRE--HETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDEL 236
++ + NG +S +Q+ L++M LD R+ +V ++ LL+ E Q L ++EL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
Query: 237 VEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITK 296
+WKRRQQ ACIGGPPN CLD+L+NW T +AES Q RQQ+KKLEEL+QK +Y+ DPI +
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
Query: 297 NKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNY 356
++ +L +R LF+ L++S+FVVERQPCMP HP RPLV+KTGVQFT K+RLLVK ELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
Query: 357 NLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQK--N 414
LK+KV DKD + ++G RKFNILGT+TKVMNMEES NGSL+AEF+HL L+EQ+ N
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
Query: 415 AGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWY 474
G + LIVTEELH ++FET++ GL IDLET SLPVVVISN+ Q+P+ WASILWY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
Query: 475 NMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPD 534
NML P+N++FF PP W Q++EVLSWQFSS TKRGL+++QL L EKLLGP +
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
Query: 535 GL-IPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKD 593
G I W +FCKEN+ K F FW+W+++I++L+KK++L LWN+G IMGFISKERERA+L
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
Query: 594 QQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKV 653
+ PGTFLLRFSESS+EG +TFTWVE+ + G+ +VEPYTK++L+ ++F +II YK+
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDIS-GKTQIQSVEPYTKQQLNNMSFAEIIMGYKI 659
Query: 654 MAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVH 713
M A NI +PL YLYP+I K+ AFGK Y RP E+ E E D Y+KT+ I V+
Sbjct: 660 MDATNILVSPLVYLYPDIPKEEAFGK-YCRP-ESQEHPEADPGSAAPYLKTKFICVT--- 714
Query: 714 PSRLQTTDNLLPMSPEEFDEV 734
P+ T + LPMSP D +
Sbjct: 715 PTTCSNTID-LPMSPRTLDSL 734
>gi|21618338 signal transducer and activator of transcription 3
isoform 2 [Homo sapiens]
Length = 769
Score = 780 bits (2014), Expect = 0.0
Identities = 393/741 (53%), Positives = 538/741 (72%), Gaps = 15/741 (2%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
M+QW +LQQLD+++LEQ+HQLY DSFPME+RQ+LA W+E QDW +AA+ S AT+ FH+L
Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
Query: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
L ++D QYSRF E+N L QHN+R+ K+ LQ + E P++++ I+ CL EE ++L+ A
Sbjct: 61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
Query: 121 RFNQ--AQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQ 178
Q Q+ + + V+ +KQ+ L+ +++V+ +V +E ++K +E+LQD++DF KTL+
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
Query: 179 NRE--HETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDEL 236
++ + NG +S +Q+ L++M LD R+ +V ++ LL+ E Q L ++EL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
Query: 237 VEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITK 296
+WKRRQQ ACIGGPPN CLD+L+NW T +AES Q RQQ+KKLEEL+QK +Y+ DPI +
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
Query: 297 NKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNY 356
++ +L +R LF+ L++S+FVVERQPCMP HP RPLV+KTGVQFT K+RLLVK ELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
Query: 357 NLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQK--N 414
LK+KV DKD + ++G RKFNILGT+TKVMNMEES NGSL+AEF+HL L+EQ+ N
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
Query: 415 AGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWY 474
G + LIVTEELH ++FET++ GL IDLET SLPVVVISN+ Q+P+ WASILWY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
Query: 475 NMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPD 534
NML P+N++FF PP W Q++EVLSWQFSS TKRGL+++QL L EKLLGP +
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
Query: 535 GL-IPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKD 593
G I W +FCKEN+ K F FW+W+++I++L+KK++L LWN+G IMGFISKERERA+L
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
Query: 594 QQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKV 653
+ PGTFLLRFSESS+EG +TFTWVE+ + G+ +VEPYTK++L+ ++F +II YK+
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDIS-GKTQIQSVEPYTKQQLNNMSFAEIIMGYKI 659
Query: 654 MAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVH 713
M A NI +PL YLYP+I K+ AFGK Y RP E+ E E D P Y+KT+ I V+
Sbjct: 660 MDATNILVSPLVYLYPDIPKEEAFGK-YCRP-ESQEHPEAD-PGAAPYLKTKFICVT--- 713
Query: 714 PSRLQTTDNLLPMSPEEFDEV 734
P+ T + LPMSP D +
Sbjct: 714 PTTCSNTID-LPMSPRTLDSL 733
>gi|47458820 signal transducer and activator of transcription 3
isoform 3 [Homo sapiens]
Length = 722
Score = 775 bits (2001), Expect = 0.0
Identities = 384/717 (53%), Positives = 526/717 (73%), Gaps = 10/717 (1%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
M+QW +LQQLD+++LEQ+HQLY DSFPME+RQ+LA W+E QDW +AA+ S AT+ FH+L
Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
Query: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
L ++D QYSRF E+N L QHN+R+ K+ LQ + E P++++ I+ CL EE ++L+ A
Sbjct: 61 LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA 120
Query: 121 RFNQ--AQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQ 178
Q Q+ + + V+ +KQ+ L+ +++V+ +V +E ++K +E+LQD++DF KTL+
Sbjct: 121 TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK 180
Query: 179 NRE--HETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDEL 236
++ + NG +S +Q+ L++M LD R+ +V ++ LL+ E Q L ++EL
Sbjct: 181 SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL 240
Query: 237 VEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITK 296
+WKRRQQ ACIGGPPN CLD+L+NW T +AES Q RQQ+KKLEEL+QK +Y+ DPI +
Sbjct: 241 ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ 300
Query: 297 NKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNY 356
++ +L +R LF+ L++S+FVVERQPCMP HP RPLV+KTGVQFT K+RLLVK ELNY
Sbjct: 301 HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY 360
Query: 357 NLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQK--N 414
LK+KV DKD + ++G RKFNILGT+TKVMNMEES NGSL+AEF+HL L+EQ+ N
Sbjct: 361 QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN 420
Query: 415 AGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWY 474
G + LIVTEELH ++FET++ GL IDLET SLPVVVISN+ Q+P+ WASILWY
Sbjct: 421 GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY 480
Query: 475 NMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPD 534
NML P+N++FF PP W Q++EVLSWQFSS TKRGL+++QL L EKLLGP +
Sbjct: 481 NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS 540
Query: 535 GL-IPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKD 593
G I W +FCKEN+ K F FW+W+++I++L+KK++L LWN+G IMGFISKERERA+L
Sbjct: 541 GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST 600
Query: 594 QQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKV 653
+ PGTFLLRFSESS+EG +TFTWVE+ + G+ +VEPYTK++L+ ++F +II YK+
Sbjct: 601 KPPGTFLLRFSESSKEGGVTFTWVEKDIS-GKTQIQSVEPYTKQQLNNMSFAEIIMGYKI 659
Query: 654 MAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVS 710
M A NI +PL YLYP+I K+ AFGK Y RP E+ E E D Y+KT+ I V+
Sbjct: 660 MDATNILVSPLVYLYPDIPKEEAFGK-YCRP-ESQEHPEADPGSAAPYLKTKFICVT 714
>gi|4507255 signal transducer and activator of transcription 4 [Homo
sapiens]
Length = 748
Score = 757 bits (1954), Expect = 0.0
Identities = 398/736 (54%), Positives = 527/736 (71%), Gaps = 16/736 (2%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
MSQW ++QQL+ KFLEQV Q YDD+FPMEIR LAQW+E QDWE A+N+ + ATI +L
Sbjct: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNL 60
Query: 61 LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ 120
L QLD+Q R S E N LL HN+++ ++ LQ F +P+ ++++I +CL+EER+IL A
Sbjct: 61 LIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAAN 120
Query: 121 RFNQAQ-SGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQN 179
Q ++QS+ + ++Q+ ++ KV +K+ V E + K LEDLQDE+D++ KT+Q
Sbjct: 121 MPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQT 180
Query: 180 REHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEW 239
+ A +Q E L L++M LD KRKE + K+ ++++ T+L N ++ +EL +W
Sbjct: 181 MDQSDKNSAMVNQ--EVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDW 238
Query: 240 KRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQ 299
KRRQQ ACIGGP + LDQLQN FT++AESL Q+R+QL+KLEE K TYE DPI +
Sbjct: 239 KRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRT 298
Query: 300 VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLK 359
+ +R L L ++SFVVERQPCMPTHPQRPLVLKT +QFTVKLRLL+KL ELNY +K
Sbjct: 299 HMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVK 358
Query: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKN-AGTR 418
VK DK+V+ + R+F + GT+ K M++EES+NGSL+ EFRHLQ KE K+ AG +
Sbjct: 359 VKASIDKNVSTLSN----RRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGK 414
Query: 419 TNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLV 478
NEG +VTEELHS++FETQ+C GL IDLET+SLPVV+ISNVSQLP+ WASI+WYN+
Sbjct: 415 GNEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVST 474
Query: 479 AEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIP 538
+ +NL FF PP A +QL EV+SWQFSS RGLN DQL+ML EKL ++ DG +
Sbjct: 475 NDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLT 534
Query: 539 WTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGT 598
W +FCKE++ K+F FW W+E+IL+LIKKH+LPLW DG +MGF+SKE+ER LLKD+ PGT
Sbjct: 535 WAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGT 594
Query: 599 FLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAEN 658
FLLRFSE S G ITFTWV+ S++ GE FH+VEPY K LSA+ F DI+R+YKV+ AEN
Sbjct: 595 FLLRFSE-SHLGGITFTWVDHSES-GEVRFHSVEPYNKGRLSALPFADILRDYKVIMAEN 652
Query: 659 IPENPLKYLYPNIDKDHAFGKYY-SRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRL 717
IPENPLKYLYP+I KD AFGK+Y S+P E P E G K GY+ + I +S +
Sbjct: 653 IPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTE-RGDK--GYVPSVFIPISTIRSDST 709
Query: 718 Q--TTDNLLPMSPEEF 731
+ + +LLPMSP +
Sbjct: 710 EPHSPSDLLPMSPSVY 725
>gi|4885615 signal transducer and activator of transcription 2 [Homo
sapiens]
Length = 851
Score = 539 bits (1389), Expect = e-153
Identities = 316/733 (43%), Positives = 448/733 (61%), Gaps = 27/733 (3%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSF-PMEIRQYLAQWLEKQDWEHAA--NDVSFATIRF 57
M+QW LQ LDS F +Q+HQLY S P++IRQYLA W+E Q+W+ AA +D S AT+ F
Sbjct: 1 MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLF 60
Query: 58 HDLLSQLDDQYSRFSLE-NNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKIL 116
L QL+ + R S + + LLQHN+RK R++Q F +DP Q++ +I++ L EE++IL
Sbjct: 61 FHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQP-FSQDPTQLAEMIFNLLLEEKRIL 119
Query: 117 ENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKT 176
AQR Q + T + +Q E++S++ +++ +E +KS+ L+D+ D C
Sbjct: 120 IQAQRAQLEQGEPVLETPVESQQHEIESRILDLR---AMMEKLVKSISQLKDQQDVFCFR 176
Query: 177 LQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLN-VTELTQNALINDE 235
+ + Q +EQ +L++ LD +RKEV+ LL +T L + L+ +
Sbjct: 177 YKIQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIE--LLLPK 234
Query: 236 LVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPIT 295
L EWK +QQ ACI P + L+QL+ WFT A+ L +RQ LK+L+ L +Y+ DP+T
Sbjct: 235 LEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLT 294
Query: 296 KNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELN 355
K + + L Q+L+ +FVVE QPCMP P RPL+LKTG +FTV+ RLLV+LQE N
Sbjct: 295 KGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGN 354
Query: 356 YNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNA 415
+L V+V D++ + ++GFRKFNIL ++ K + E+ + L +F +L L EQ++
Sbjct: 355 ESLTVEVSIDRNPPQ---LQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSG 411
Query: 416 GT--RTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILW 473
G+ +N+GPL VTEELH +SF + GL +L+T +LPVV+ISN++QL WAS+LW
Sbjct: 412 GSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLW 471
Query: 474 YNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNA-S 532
+N+L +N FF PP A W+ L LSWQFSS RGLN DQL+ML KL G N +
Sbjct: 472 FNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRT 531
Query: 533 PDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLK 592
D L+ W F K PFW W++ ILEL+ HL LWNDG IMGF+S+ +ER LLK
Sbjct: 532 EDPLLSWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLK 591
Query: 593 DQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYK 652
GTFLLRFSESS EG IT +WVE Q+ + ++V+PYTK+ L ++ +IIR+Y+
Sbjct: 592 KTMSGTFLLRFSESS-EGGITCSWVEH-QDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQ 649
Query: 653 VMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEV 712
++ ENIPENPL++LYP I +D AFG YY E + Y+K LI VS
Sbjct: 650 LLTEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLQERRK--------YLKHRLIVVSNR 701
Query: 713 HPSRLQTTDNLLP 725
LQ L P
Sbjct: 702 QVDELQQPLELKP 714
>gi|21618344 signal transducer and activator of transcription 5B
[Homo sapiens]
Length = 787
Score = 298 bits (762), Expect = 2e-80
Identities = 231/749 (30%), Positives = 371/749 (49%), Gaps = 82/749 (10%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL 60
M+ W + QQL + L Q+ LY FP+E+R YL+QW+E Q W+ D I+ L
Sbjct: 1 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL 60
Query: 61 LSQLDDQYSRFSL----ENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKIL 116
L L + + + E+ FLL+ + LQ+ + P+++ I L E++++
Sbjct: 61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120
Query: 117 ENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKT 176
A N + + M K +++ ++ E+E+K L+ Q+ + + +
Sbjct: 121 REAN--NGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQE 178
Query: 177 LQNREHETNGVAKSD------------QKQEQL--LLKKMYLMLDNKRKEVVHKIIELLN 222
+ + +A+ QKQ L L++ L R E+ K + L
Sbjct: 179 SLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQ 238
Query: 223 VTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEE 282
+ Q +++DEL++WKRRQQ A GGPP LD LQ+W +AE + Q RQQ+++ E
Sbjct: 239 LLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEH 298
Query: 283 LEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFT 342
L Q+ P+ + + + L+ S+F++E+QP P VLKT +F
Sbjct: 299 LCQQLPIP-GPVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFA 349
Query: 343 VKLRLLVKLQELNYNL-----KVKVLFD-------KDVNERNTVKGFRKFNILGTHTKVM 390
+RLLV +LN ++ K ++ + K+ N RN G IL + VM
Sbjct: 350 ATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSG----EILN-NCCVM 403
Query: 391 NMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPG--LVIDL 448
++T G+L+A FR++ LK K + R E VTEE ++ FE+Q G LV +
Sbjct: 404 EYHQAT-GTLSAHFRNMSLKRIKRSDRRGAES---VTEEKFTILFESQFSVGGNELVFQV 459
Query: 449 ETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSS 508
+T SLPVVVI + SQ + A++LW N AEP + F + P W QL E L+ +F +
Sbjct: 460 KTLSLPVVVIVHGSQDNNATATVLWDNAF-AEPGRVPFAV-PDKVLWPQLCEALNMKFKA 517
Query: 509 VTK--RGLNVDQLNMLGEKLLGPNASP----DGL-IPWTRFCKENINDKNFPFWLWIESI 561
+ RGL + L L +KL ++S GL + W++F +EN+ +N+ FW W + +
Sbjct: 518 EVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGV 577
Query: 562 LELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQ 621
+E++KKHL P WNDG I+GF++K++ LL ++ GTFLLRFS+ S G IT W SQ
Sbjct: 578 MEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAWKFDSQ 636
Query: 622 NGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYY 681
E F + P+T ++ S + D + + N L Y++P+ KD + KYY
Sbjct: 637 ---ERMFWNLMPFTTRDFSIRSLADRLGDL----------NYLIYVFPDRPKDEVYSKYY 683
Query: 682 SRPKEAPEPMELDGPKGT-GYIKTELISV 709
+ P P E K GY+K ++ V
Sbjct: 684 T-----PVPCESATAKAVDGYVKPQIKQV 707
>gi|21618342 signal transducer and activator of transcription 5A
[Homo sapiens]
Length = 794
Score = 286 bits (731), Expect = 6e-77
Identities = 221/721 (30%), Positives = 351/721 (48%), Gaps = 76/721 (10%)
Query: 1 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHA----ANDVSFATIR 56
M+ W + QQL L Q+ LY FP+E+R YLAQW+E Q W+ D + AT
Sbjct: 1 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
Query: 57 FHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKIL 116
L+ +L + E+ FLL+ + LQ + P+++ I L E++++
Sbjct: 61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
Query: 117 ENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEY------ 170
A N + I M K +++ ++ E+E+K L+ Q+ +
Sbjct: 121 REAN--NCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQE 178
Query: 171 ------DFKCKTLQNREHETNGVAKSDQKQEQL--LLKKMYLMLDNKRKEVVHKIIELLN 222
F + + + QKQ L L++ L R E+ K + L
Sbjct: 179 SLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQ 238
Query: 223 VTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEE 282
+ Q +++DEL++WKRRQQ A GGPP LD LQ+W +AE + Q RQQ+++ E
Sbjct: 239 LLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEH 298
Query: 283 LEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFT 342
L Q+ P+ + + + L+ S+F++E+QP P VLKT +F
Sbjct: 299 LCQQLPIP-GPVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFA 349
Query: 343 VKLRLLVKLQELNYNL-----KVKVLFD-------KDVNERNTVKGFRKFNILGTHTKVM 390
+RLLV +LN ++ K ++ + K+ N RN G IL + VM
Sbjct: 350 ATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG----EILN-NCCVM 403
Query: 391 NMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPG--LVIDL 448
++T G+L+A FR++ LK K A R E VTEE ++ FE+Q LV +
Sbjct: 404 EYHQAT-GTLSAHFRNMSLKRIKRADRRGAES---VTEEKFTVLFESQFSVGSNELVFQV 459
Query: 449 ETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSS 508
+T SLPVVVI + SQ + A++LW N AEP + F + P W QL E L+ +F +
Sbjct: 460 KTLSLPVVVIVHGSQDHNATATVLWDNAF-AEPGRVPFAV-PDKVLWPQLCEALNMKFKA 517
Query: 509 VTK--RGLNVDQLNMLGEKLLGPNASP----DGL-IPWTRFCKENINDKNFPFWLWIESI 561
+ RGL + L L +KL ++S GL + W++F +EN+ N+ FW W + +
Sbjct: 518 EVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGV 577
Query: 562 LELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQ 621
+E++KKH P WNDG I+GF++K++ LL ++ GTFLLRFS+ S G IT W
Sbjct: 578 MEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW---KF 633
Query: 622 NGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYY 681
+ E + ++P+T ++ S + D + + L Y++P+ KD F KYY
Sbjct: 634 DSPERNLWNLKPFTTRDFSIRSLADRLGDLSY----------LIYVFPDRPKDEVFSKYY 683
Query: 682 S 682
+
Sbjct: 684 T 684
>gi|23397678 signal transducer and activator of transcription 6
[Homo sapiens]
Length = 847
Score = 177 bits (450), Expect = 2e-44
Identities = 203/750 (27%), Positives = 321/750 (42%), Gaps = 124/750 (16%)
Query: 16 EQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSL-- 73
E+V +LY D FP +R L WLE Q WE +F LLS Q+ + S+
Sbjct: 13 EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTV-QHLQASVGE 70
Query: 74 --ENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQ 131
E + +LQH L+ +Q DP+++ L+ E+K + R
Sbjct: 71 QGEGSTILQHI-----STLESIYQRDPLKLVATFRQILQGEKKAVMEQFR---------- 115
Query: 132 STVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKC--KTLQNREHETNGVAK 189
H Q+E FK + LQ+R E + + +
Sbjct: 116 --------------------------HLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLRE 149
Query: 190 SDQKQEQLLLKKMYLMLDNKRK-----EVVHKIIELLNVTELTQNALINDELVEWKRRQQ 244
+ QK + ++ +++ E + +++ AL+ + WKR+QQ
Sbjct: 150 ALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQ 209
Query: 245 SACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLE-ELEQKYTYEHDPITKNKQVLWD 303
A G P L LQ + + Q++Q++ ELE K + L
Sbjct: 210 LAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPK----------TRASLTG 259
Query: 304 RTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVL 363
R + + L+ S F+VE+QP P VLKT +F +R L+ L+ L K ++
Sbjct: 260 RLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLV 311
Query: 364 FDKDVNERNTVKGFRKFNI-----LGTHT--KVMN----MEESTNGSL-AAEFRHLQLKE 411
V E+ R+ ++ G + +++N +E S G+ +A F++L LK+
Sbjct: 312 RADMVTEKQA----RELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKK 367
Query: 412 QKNAGTRTNEGPLIVTEELHSLSFETQLCQ-PG-LVIDLETTSLPVVVISNVSQLPSGWA 469
K + E VTEE ++ F PG L I L+ SLP+VVI + +Q + A
Sbjct: 368 IKRCERKGTES---VTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKA 424
Query: 470 SILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSV--TKRGLNVDQLNMLGEKLL 527
+ILW N R F+ W ++ E L+ +F + T RGL + L +K+
Sbjct: 425 TILWDNAFSEMDRVP--FVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIF 482
Query: 528 GPN-----ASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFI 582
N A + W++F KE + + F FW W + +L+L K+ L W+D I+GFI
Sbjct: 483 NDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFI 542
Query: 583 SKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAV 642
SK+ +LL ++ GTFLLRFS+ S G IT V R Q+ G P ++P++ K+LS
Sbjct: 543 SKQYVTSLLLNEPDGTFLLRFSD-SEIGGITIAHVIRGQD-GSPQIENIQPFSAKDLSIR 600
Query: 643 TFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYI 702
+ D IR+ LK LYP KD AF +Y PE M G G GY+
Sbjct: 601 SLGDRIRDLA----------QLKNLYPKKPKDEAFRSHYK-----PEQM---GKDGRGYV 642
Query: 703 KTELISVSEVHPSRLQTTDNLLPMSPEEFD 732
I ++ L T + +P +D
Sbjct: 643 PA-TIKMTVERDQPLPTPELQMPTMVPSYD 671
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 43.1 bits (100), Expect = 0.001
Identities = 85/397 (21%), Positives = 166/397 (41%), Gaps = 48/397 (12%)
Query: 79 LQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQR---FNQAQSGNIQSTVM 135
L+ + + L D QE QM + + +E +L +A+ + + V
Sbjct: 263 LRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVR 321
Query: 136 LDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGV-AKSDQ-- 192
+DK L+S+V K+++ IE +E+L+++ +T E + G A+SD+
Sbjct: 322 VDK---LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 193 --KQEQLLLKKMYLMLDNKRKEVVHKIIELL--NVT-ELTQNALINDEL-VEWKRRQQSA 246
++E L LK ++ +R KI EL+ N+T E+ Q +++ L + W+ Q S
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 438
Query: 247 C--IGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKN-----KQ 299
+ P L N T + L ++ + + L + ++ D + N K
Sbjct: 439 TSELSEAPQKSLGHEVNELT--SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496
Query: 300 VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLK 359
++ S +++++ V E+Q ++K Q + L + N +
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE----NSERQ 552
Query: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEES----------TNGSLAA-EFRHLQ 408
+K+L ++ + TV R+ + + +V ++E+ T+ L+ EF Q
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 409 LKEQ----KNAGTRTNEGPLIVTEELHSLSFETQLCQ 441
+K++ K G R E + ELH L E +L Q
Sbjct: 613 IKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645
Score = 30.8 bits (68), Expect = 4.8
Identities = 53/263 (20%), Positives = 117/263 (44%), Gaps = 35/263 (13%)
Query: 82 NIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKE 141
+I K + L ++ +E ++S I + ++ +K LE+ + + L+K+ E
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFE-KRQIKKELEHYKEKGERAEELENELHHLEKENE 642
Query: 142 L-DSKVRNVK---DKVMCIEHEIKSLE----------DLQDEYDFKCKTLQNR----EHE 183
L K+ N+K +K+ +E E LE D F+ ++L+ + E
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 184 TNGVAKSDQKQEQLLLKKMYLMLDNK----RKEVVHKIIELLNVT-ELTQNALINDELVE 238
+ ++ + + +K L L+NK KE + K +ELL + + T+ ++ + ++
Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762
Query: 239 WKRRQQSACIGGPPNACLDQLQNWF-------TIVAESLQQVRQQLKKLEELEQK---YT 288
+ ++ + N + QL++ + ++L++++ K+LE+LE++
Sbjct: 763 IENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
Query: 289 YEHDPITKNKQVLWDRTFSLFQQ 311
E + K+K+ L L QQ
Sbjct: 822 QETSQLEKDKKQLEKENKRLRQQ 844
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 43.1 bits (100), Expect = 0.001
Identities = 85/397 (21%), Positives = 166/397 (41%), Gaps = 48/397 (12%)
Query: 79 LQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQR---FNQAQSGNIQSTVM 135
L+ + + L D QE QM + + +E +L +A+ + + V
Sbjct: 263 LRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVR 321
Query: 136 LDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGV-AKSDQ-- 192
+DK L+S+V K+++ IE +E+L+++ +T E + G A+SD+
Sbjct: 322 VDK---LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 193 --KQEQLLLKKMYLMLDNKRKEVVHKIIELL--NVT-ELTQNALINDEL-VEWKRRQQSA 246
++E L LK ++ +R KI EL+ N+T E+ Q +++ L + W+ Q S
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 438
Query: 247 C--IGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKN-----KQ 299
+ P L N T + L ++ + + L + ++ D + N K
Sbjct: 439 TSELSEAPQKSLGHEVNELT--SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496
Query: 300 VLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLK 359
++ S +++++ V E+Q ++K Q + L + N +
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE----NSERQ 552
Query: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEES----------TNGSLAA-EFRHLQ 408
+K+L ++ + TV R+ + + +V ++E+ T+ L+ EF Q
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 409 LKEQ----KNAGTRTNEGPLIVTEELHSLSFETQLCQ 441
+K++ K G R E + ELH L E +L Q
Sbjct: 613 IKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645
Score = 30.8 bits (68), Expect = 4.8
Identities = 53/263 (20%), Positives = 117/263 (44%), Gaps = 35/263 (13%)
Query: 82 NIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKE 141
+I K + L ++ +E ++S I + ++ +K LE+ + + L+K+ E
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFE-KRQIKKELEHYKEKGERAEELENELHHLEKENE 642
Query: 142 L-DSKVRNVK---DKVMCIEHEIKSLE----------DLQDEYDFKCKTLQNR----EHE 183
L K+ N+K +K+ +E E LE D F+ ++L+ + E
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 184 TNGVAKSDQKQEQLLLKKMYLMLDNK----RKEVVHKIIELLNVT-ELTQNALINDELVE 238
+ ++ + + +K L L+NK KE + K +ELL + + T+ ++ + ++
Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762
Query: 239 WKRRQQSACIGGPPNACLDQLQNWF-------TIVAESLQQVRQQLKKLEELEQK---YT 288
+ ++ + N + QL++ + ++L++++ K+LE+LE++
Sbjct: 763 IENQRLQKTLEN-SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
Query: 289 YEHDPITKNKQVLWDRTFSLFQQ 311
E + K+K+ L L QQ
Sbjct: 822 QETSQLEKDKKQLEKENKRLRQQ 844
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 42.4 bits (98), Expect = 0.002
Identities = 69/335 (20%), Positives = 129/335 (38%), Gaps = 31/335 (9%)
Query: 109 LKEERKILENAQRFNQAQSGNIQSTVMLDKQ--------KELDSKVRNVKDKVMCIEHEI 160
L++E+K L+ + + + Q T +++ + KEL+ K+ N +K+ +E EI
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190
Query: 161 KSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIEL 220
K + Q+ + +LQ+ + + + K +QLL+K + D+K+ E H I++
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQ---YEEKNTKIKQLLVKTKKELADSKQAETDHLILQA 1247
Query: 221 LNVTEL-----------TQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAES 269
EL Q A I E + K + L Q T + E
Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSE--KHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE 1305
Query: 270 LQQVR-QQLKKLEELEQKYTYEHDPI--TKNKQVLWDRTFSLFQQLIQSSFVVERQPCMP 326
+ + +Q E E H+ + KNK + T Q+ ++++
Sbjct: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
Query: 327 THPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTH 386
Q L + T++ L+ N L+ V + ++ E+ + H
Sbjct: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
Query: 387 TKVMNMEESTNGSLAAEF----RHLQLKEQKNAGT 417
T+ ++ S N L F RHLQ + +K T
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVET 1460
Score = 35.8 bits (81), Expect = 0.15
Identities = 34/169 (20%), Positives = 78/169 (46%), Gaps = 16/169 (9%)
Query: 65 DDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQ 124
D+Q L+ N ++ + + ++L+D +E Q +S LK+E + N + +
Sbjct: 312 DNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQ-----HSILKDEVTYMNNLKLKLE 366
Query: 125 AQSGNIQSTVMLDKQKELDSKVRNV---KDKVMCIEHEIKS-LEDLQDEYDFKCKTLQNR 180
+ +I+ ++++L+ K+ + K++ C+ ++KS L L ++ C T++
Sbjct: 367 MDAQHIKDE-FFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQF---CYTVEQH 422
Query: 181 EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQN 229
E + + QK+ L + L + KE + + E+ + E +N
Sbjct: 423 NREVQSLKEQHQKEISELNE---TFLSDSEKEKLTLMFEIQGLKEQCEN 468
Score = 33.1 bits (74), Expect = 0.97
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 15/91 (16%)
Query: 151 DKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKR 210
+KV+ +E EIK L Q+E +C+ L++ D +QE++LL+K + +++
Sbjct: 806 EKVLELEKEIKCL---QEESVVQCEELKS--------LLRDYEQEKVLLRKELEEIQSEK 854
Query: 211 KEVVHKIIELLNVTELT----QNALINDELV 237
+ + ++E+ N E T QN LI E V
Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEV 885
Score = 32.3 bits (72), Expect = 1.7
Identities = 57/253 (22%), Positives = 103/253 (40%), Gaps = 37/253 (14%)
Query: 39 EKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLE----NNFLLQHNIRKSKRNLQDN- 93
EK + D+ + +LL + + Q + +E NNF +H I R L+++
Sbjct: 1001 EKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNF--EHRIEDLTRQLRNST 1058
Query: 94 FQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQ-STVMLDKQKELDSKVRNVKDK 152
Q + I L + L++ + + Q +Q + M+DK+ E + + K K
Sbjct: 1059 LQCETINSDN---EDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115
Query: 153 VMCIEHE--IKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKR 210
EH + LE+LQ + + K LQ E + K D +Q L+ N
Sbjct: 1116 ----EHATTVNELEELQVQLQKEKKQLQKTMQELE-LVKKDAQQTTLM---------NME 1161
Query: 211 KEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESL 270
++++ LN +N I D E K ++Q + LQ T + S+
Sbjct: 1162 IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ----------ETLQEEITSLQSSV 1211
Query: 271 QQVRQQLKKLEEL 283
QQ ++ K+++L
Sbjct: 1212 QQYEEKNTKIKQL 1224
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 42.0 bits (97), Expect = 0.002
Identities = 66/306 (21%), Positives = 125/306 (40%), Gaps = 34/306 (11%)
Query: 8 QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQ 67
Q+ D + E V D F ++ +A ++ E D R D + + Q
Sbjct: 166 QEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEAD---RYQRLKDEVVRAQVQ 222
Query: 68 YSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQS 127
F L +N + + K + ++D +M + LKE++K L R Q
Sbjct: 223 LQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDE-LKEKKKELGKMMREQQQIE 281
Query: 128 GNIQSTVMLDKQKELDSK-------VRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR 180
I+ +K EL+ K N K+ +E KSL++ Q Y + +
Sbjct: 282 KEIK-----EKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDEL 336
Query: 181 EHETNGVAKSDQKQEQLLLKKMY-----LMLDNKRKEVVHKIIELLNVTELTQNALINDE 235
E E V K+ Q+ E+ + ++ L L+ + + H++ E + + A + E
Sbjct: 337 EKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEAS----KRAATLAQE 392
Query: 236 LVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPIT 295
L ++ R Q+ A D+L E+ +++Q+L+++EE +++ + IT
Sbjct: 393 LEKFNRDQK---------ADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYIT 443
Query: 296 KNKQVL 301
+KQ L
Sbjct: 444 TSKQSL 449
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/182 (24%), Positives = 82/182 (45%), Gaps = 21/182 (11%)
Query: 38 LEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFL----LQHNIRKSKRNLQDN 93
L KQ+ E ++ + ++L + LEN+ L LQH+ R S+
Sbjct: 1672 LIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL----- 1726
Query: 94 FQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNI--QSTVMLDKQKELDSKVRNVKD 151
+ Q++++ EE+ LEN Q+ +Q Q G I Q ++ ++E++ +
Sbjct: 1727 ---EKTQVAVL------EEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRA 1777
Query: 152 KVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRK 211
C+E K EDLQ++ D K L + A+ + K EQ L+K+ L + ++
Sbjct: 1778 LQSCVECLSKEKEDLQEKCDIWEKKLAQTK-RVLAAAEENSKMEQSNLEKLELNVRKLQQ 1836
Query: 212 EV 213
E+
Sbjct: 1837 EL 1838
Score = 37.0 bits (84), Expect = 0.067
Identities = 51/252 (20%), Positives = 111/252 (44%), Gaps = 36/252 (14%)
Query: 49 DVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSC 108
D+S RF D Q +++ + L+ +LQ+ I ++K L +Q M+
Sbjct: 1907 DISEWANRFEDC--QKEEETKQQQLQ---VLQNEIEENKLKL--------VQQEMMFQRL 1953
Query: 109 LKE---ERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLED 165
KE E LE ++ + Q ++ + K SK+ V KV+ E +++L+
Sbjct: 1954 QKERESEESKLETSKVTLKEQQHQLEKELTDQK-----SKLDQVLSKVLAAEERVRTLQ- 2007
Query: 166 LQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTE 225
E + C++L+ +T + ++++QL+ K L+ K + + LL
Sbjct: 2008 ---EEERWCESLEKTLSQTK--RQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQF 2062
Query: 226 LTQNALINDELVEWK--------RRQQSACIGGPPNACLDQLQNWFTIVA-ESLQQVRQQ 276
LT+ ++ K + +++ N+C+ + +VA ++ ++ R+
Sbjct: 2063 LTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRL 2122
Query: 277 LKKLEELEQKYT 288
+K+L +++ +YT
Sbjct: 2123 MKELNQMQYEYT 2134
>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
sapiens]
Length = 1907
Score = 41.2 bits (95), Expect = 0.004
Identities = 37/178 (20%), Positives = 84/178 (47%), Gaps = 15/178 (8%)
Query: 131 QSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKS 190
++T ++ K + K++ K V + L D +Y K KTL+ + + AK+
Sbjct: 1226 ENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKYKDKIKTLEKNQEILDDTAKN 1285
Query: 191 -----DQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQ------NALINDELVE- 238
+ ++EQ + K L+ +NK+ K + +N +E ++ A +++E V+
Sbjct: 1286 LRVMLESEREQNV-KNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEAKLSEEKVKS 1344
Query: 239 --WKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPI 294
+ ++++A + ++++W + AE +Q++ K ++LE T++ D I
Sbjct: 1345 ECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDDNI 1402
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 40.8 bits (94), Expect = 0.005
Identities = 64/307 (20%), Positives = 138/307 (44%), Gaps = 48/307 (15%)
Query: 6 ELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLD 65
ELQ+ D + Q Q+ + +++L Q LE++D E + + L+
Sbjct: 1624 ELQERDQEVKSQREQIEE---LQRQKEHLTQDLERRDQELMLQK---------ERIQVLE 1671
Query: 66 DQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQA 125
DQ +R +L+ ++ + K +L++ +E Q ++ +ER E + ++A
Sbjct: 1672 DQRTR----QTKILEEDLEQIKLSLRERGRELTTQRQLM------QERA--EEGKGPSKA 1719
Query: 126 QSGNIQ--STVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHE 183
Q G+++ ++ DK+KE++ C + I L++L+D+ + + + L + E
Sbjct: 1720 QRGSLEHMKLILRDKEKEVE-----------CQQEHIHELQELKDQLEQQLQGLHRKVGE 1768
Query: 184 TNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALI--NDELVEWKR 241
T+ + S ++QE ++L++ L R++ K L + + Q AL + EL ++
Sbjct: 1769 TS-LLLSQREQEIVVLQQ---QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQ 1824
Query: 242 RQQSA-----CIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITK 296
QQ A + +A L+ + E +++ ++ LE++ E +
Sbjct: 1825 EQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884
Query: 297 NKQVLWD 303
++VL D
Sbjct: 1885 LEEVLGD 1891
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 40.4 bits (93), Expect = 0.006
Identities = 46/207 (22%), Positives = 93/207 (44%), Gaps = 13/207 (6%)
Query: 107 SCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDL 166
S L+E+R+ +E + VM +++ +++ R K + + H LE L
Sbjct: 834 SLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEER--KQRAELLGHLTGELERL 891
Query: 167 QDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTEL 226
Q ++ + +T++ +H+ + ++++ L+ + L L+ + K+V + + LL V E
Sbjct: 892 QRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR-LALLEVQEE 950
Query: 227 T-----QNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLE 281
T Q L V K + +A + L++ Q T + +S QQ+R+ L +L+
Sbjct: 951 TARREKQQLLDVQRQVALKSEEATA-----THQQLEEAQKEHTHLLQSNQQLREILDELQ 1005
Query: 282 ELEQKYTYEHDPITKNKQVLWDRTFSL 308
+ K + D + Q L SL
Sbjct: 1006 ARKLKLESQVDLLQAQSQQLQKHFSSL 1032
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 40.0 bits (92), Expect = 0.008
Identities = 49/251 (19%), Positives = 106/251 (42%), Gaps = 16/251 (6%)
Query: 64 LDDQYSRFS--LENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSC----LKEERKILE 117
LDD S + L +N L+ ++ +K +++ ++ + + LKE++ + E
Sbjct: 2084 LDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQE 2143
Query: 118 NAQRFNQAQS------GNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYD 171
+ + G IQ T+ K KE+ N+ V + KS+ LQD+ D
Sbjct: 2144 KLDALRREKVHLEETIGEIQVTLN-KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRD 2202
Query: 172 FKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNAL 231
+ E + + +S +++ +L ++ D R+ +H +N++ L +
Sbjct: 2203 RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262
Query: 232 INDELVEWK-RRQQSAC--IGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYT 288
I + + + + QQ C + G L QL+ + S ++ + +L+ L+ + T
Sbjct: 2263 IWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT 2322
Query: 289 YEHDPITKNKQ 299
+ + K K+
Sbjct: 2323 DLSNSLEKCKE 2333
Score = 37.0 bits (84), Expect = 0.067
Identities = 57/239 (23%), Positives = 107/239 (44%), Gaps = 40/239 (16%)
Query: 79 LQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDK 138
L+ N K++ + N E ++S + +++E ++ A + + T + ++
Sbjct: 696 LELNFHKAQEIYEKNLDEKAKEISNL--------NQLIEEFKK--NADNNSSAFTALSEE 745
Query: 139 QKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLL 198
+ +L S+V+ + V + ++K LE L E + +S + LL
Sbjct: 746 RDQLLSQVKELS-MVTELRAQVKQLE----------MNLAEAERQRRLDYESQTAHDNLL 794
Query: 199 LKKMY-LMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLD 257
++++ L ++ K K+V KI E+ QN L + V+ + +QS I +
Sbjct: 795 TEQIHSLSIEAKSKDV--KI-------EVLQNELDD---VQLQFSEQSTLI----RSLQS 838
Query: 258 QLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWD--RTFSLFQQLIQ 314
QLQN + V E ++VR K+EEL Q + + ITK Q+L + R QQ I+
Sbjct: 839 QLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE 897
Score = 35.8 bits (81), Expect = 0.15
Identities = 41/208 (19%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 101 MSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSK-------VRNVKDKV 153
+ + + +++ K+++ + ++ +ST +K KEL + NV ++
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIA--ESTEWQEKHKELQKEYEILLQSYENVSNEA 1629
Query: 154 MCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEV 213
I+H ++++ + E K ++ + + ET +KQ Q ++M M + RK
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKET-------EKQLQEAEQEMEEMKEKMRKFA 1682
Query: 214 VHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQV 273
K ++L + E ND L R + G C++ L + + E L++V
Sbjct: 1683 KSKQQKILELEE------ENDRL-----RAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 274 RQQLKKLEELEQKYTYEHDPITKNKQVL 301
+ + + L + Q E D +++ Q L
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
Score = 35.8 bits (81), Expect = 0.15
Identities = 39/203 (19%), Positives = 87/203 (42%), Gaps = 16/203 (7%)
Query: 85 KSKRNLQDNFQEDPIQMSMII--YSCLKEER-KILENAQRFNQAQSGNIQSTVMLDKQKE 141
K + LQ+N Q++ S L+++R ++++ A+++ + S IQS
Sbjct: 2171 KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSK-------- 2222
Query: 142 LDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKK 201
+ ++R +D ++ +++ + +E L EH+ + +S + E L +K
Sbjct: 2223 -EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL---EHDKQ-IWESKAQTEVQLQQK 2277
Query: 202 MYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQN 261
+ L + KE++ ++ E ++ +QN L E + Q + C +Q N
Sbjct: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN 2337
Query: 262 WFTIVAESLQQVRQQLKKLEELE 284
I+ + ++ E+LE
Sbjct: 2338 LEGIIRQQEADIQNSKFSYEQLE 2360
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 40.0 bits (92), Expect = 0.008
Identities = 81/395 (20%), Positives = 176/395 (44%), Gaps = 59/395 (14%)
Query: 48 NDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYS 107
N VS TI+ L S L+ L N L+ N K ++ L+ +E +Y
Sbjct: 835 NQVSEETIKVRQLDSALEICKEELVLHLN-QLEGNKEKFEKQLKKKSEE--------VY- 884
Query: 108 CLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRN--VKDKVMCIEHEIKSLE- 164
CL++E KI ++ + Q+ +Q T+ +Q +RN ++D +E ++ LE
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 944
Query: 165 DLQDEYDFKCKTLQNREHETNGVA-KSDQKQEQLL-----LKKMYLMLDNKRKEVVHKII 218
+LQ + + + L+ E + A ++D K+++++ +++ + +D ++E+
Sbjct: 945 ELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004
Query: 219 ELLNVTELTQNALINDELVEWKRRQQSACIGGPPNAC--LDQLQ-NWFTIVAESLQ---- 271
E++++ +N ++ ++ Q + NA L++LQ + T + E+LQ
Sbjct: 1005 EIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREV 1064
Query: 272 ----------QVRQQLKKLEE-----------LEQKYTYEHD---PITKNKQVLWDRTFS 307
+++ L++L+E LE+KYT D + + K + D+
Sbjct: 1065 LETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQE 1124
Query: 308 LF---QQLIQSSFVVERQPCMPTHPQRPLVLKTG--VQFTVKLRLLVKLQELNY---NLK 359
L Q L + ++ ++++ TH + G Q +KL ++ EL N +
Sbjct: 1125 LLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQ 1184
Query: 360 VKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEE 394
++ L DK N + ++ ++F +L ++ +++
Sbjct: 1185 IESLNDKLQNAKEQLRE-KEFIMLQNEQEISQLKK 1218
>gi|134152674 rabaptin, RAB GTPase binding effector protein 1
isoform 2 [Homo sapiens]
Length = 829
Score = 39.7 bits (91), Expect = 0.010
Identities = 52/251 (20%), Positives = 103/251 (41%), Gaps = 36/251 (14%)
Query: 3 QWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLS 62
QW E +++ + Y+ F + + Q QW + + E A +++ DL
Sbjct: 109 QWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYR--ESAEREIA-------DLRR 159
Query: 63 QLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKE----ERKILEN 118
+L + +LEN ++K+ QED ++ ++ KE + K+ E
Sbjct: 160 RLSEGQEEENLENE------MKKA--------QEDAEKLRSVVMPMEKEIAALKDKLTEA 205
Query: 119 AQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSL-----EDLQDEYDFK 173
+ + ++ ++ L+ E + R + + + + KS+ E L+ E
Sbjct: 206 EDKIKELEASKVKE---LNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEV 262
Query: 174 CKTLQNREHETNGVAKSDQK-QEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALI 232
C L+ + N + + QK +Q L + LM D +R E+V +L V EL +
Sbjct: 263 CHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQE 322
Query: 233 NDELVEWKRRQ 243
+DE +R+
Sbjct: 323 DDEQQRLNKRK 333
>gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform
1 [Homo sapiens]
Length = 862
Score = 39.7 bits (91), Expect = 0.010
Identities = 52/251 (20%), Positives = 103/251 (41%), Gaps = 36/251 (14%)
Query: 3 QWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLS 62
QW E +++ + Y+ F + + Q QW + + E A +++ DL
Sbjct: 109 QWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYR--ESAEREIA-------DLRR 159
Query: 63 QLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKE----ERKILEN 118
+L + +LEN ++K+ QED ++ ++ KE + K+ E
Sbjct: 160 RLSEGQEEENLENE------MKKA--------QEDAEKLRSVVMPMEKEIAALKDKLTEA 205
Query: 119 AQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSL-----EDLQDEYDFK 173
+ + ++ ++ L+ E + R + + + + KS+ E L+ E
Sbjct: 206 EDKIKELEASKVKE---LNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEV 262
Query: 174 CKTLQNREHETNGVAKSDQK-QEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALI 232
C L+ + N + + QK +Q L + LM D +R E+V +L V EL +
Sbjct: 263 CHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQE 322
Query: 233 NDELVEWKRRQ 243
+DE +R+
Sbjct: 323 DDEQQRLNKRK 333
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 39.3 bits (90), Expect = 0.014
Identities = 46/186 (24%), Positives = 81/186 (43%), Gaps = 19/186 (10%)
Query: 138 KQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNRE-----HETNGVAKSDQ 192
KQ+EL++ + +++ E K Q E + T RE VA+
Sbjct: 351 KQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSS 410
Query: 193 KQEQLL-----LKKMYLML-----DNKRKEVVHKIIELLNVTELTQNALINDELVEWKRR 242
+ EQ L L+ MYL L D ++ + + L L + + EL +W
Sbjct: 411 ELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLE 470
Query: 243 QQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYE-HDPITKNKQVL 301
QQ A A +L+N + ++LQ+ +QL++L ELE+K E ++ + K ++
Sbjct: 471 QQQAI--QTTEAEKQELENQRVLKEQALQEAMEQLEQL-ELERKQALEQYEEVKKKLEMA 527
Query: 302 WDRTFS 307
++T S
Sbjct: 528 TNKTKS 533
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 39.3 bits (90), Expect = 0.014
Identities = 61/317 (19%), Positives = 137/317 (43%), Gaps = 41/317 (12%)
Query: 8 QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHD----LLSQ 63
Q + K E+V +D+ R+ L D + D++ ++ D L
Sbjct: 845 QYVPVKTHEEVKMTLNDTLAKTNRELL-------DVKKKFEDINQEFVKIKDKNEILKRN 897
Query: 64 LDDQYSRFSLENNFLLQH-----NIRKSKRNLQD-------NFQEDPIQMSMIIYSCLKE 111
L++ ++ E L +H ++ +S R +QD N+++ ++ + +++ +K
Sbjct: 898 LENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI-VTLHAEIKA 956
Query: 112 ERKILENAQRFNQAQSGNIQSTVMLDK-----QKELDSKVRNVKDKVMCIEHEIKSLEDL 166
++K L+ Q + + I S ++ +KEL ++ K E E+K +
Sbjct: 957 QKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1016
Query: 167 QDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTE- 225
D+ + TLQ + + + + E+ L +K L+ + K++ K E+ NV E
Sbjct: 1017 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD-ELNKQLKDLSQKYTEVKNVKEK 1075
Query: 226 -LTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELE 284
+ +NA E++ + Q + L+Q++ + +++ ++++LK ++
Sbjct: 1076 LVEENAKQTSEILAVQNLLQK------QHVPLEQVEALKKSLNGTIENLKEELKSMQRCY 1129
Query: 285 QKYTYEHDPITKNKQVL 301
+K E +TK Q+L
Sbjct: 1130 EK---EQQTVTKLHQLL 1143
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 39.3 bits (90), Expect = 0.014
Identities = 61/317 (19%), Positives = 137/317 (43%), Gaps = 41/317 (12%)
Query: 8 QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHD----LLSQ 63
Q + K E+V +D+ R+ L D + D++ ++ D L
Sbjct: 858 QYVPVKTHEEVKMTLNDTLAKTNRELL-------DVKKKFEDINQEFVKIKDKNEILKRN 910
Query: 64 LDDQYSRFSLENNFLLQH-----NIRKSKRNLQD-------NFQEDPIQMSMIIYSCLKE 111
L++ ++ E L +H ++ +S R +QD N+++ ++ + +++ +K
Sbjct: 911 LENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI-VTLHAEIKA 969
Query: 112 ERKILENAQRFNQAQSGNIQSTVMLDK-----QKELDSKVRNVKDKVMCIEHEIKSLEDL 166
++K L+ Q + + I S ++ +KEL ++ K E E+K +
Sbjct: 970 QKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1029
Query: 167 QDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTE- 225
D+ + TLQ + + + + E+ L +K L+ + K++ K E+ NV E
Sbjct: 1030 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD-ELNKQLKDLSQKYTEVKNVKEK 1088
Query: 226 -LTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELE 284
+ +NA E++ + Q + L+Q++ + +++ ++++LK ++
Sbjct: 1089 LVEENAKQTSEILAVQNLLQK------QHVPLEQVEALKKSLNGTIENLKEELKSMQRCY 1142
Query: 285 QKYTYEHDPITKNKQVL 301
+K E +TK Q+L
Sbjct: 1143 EK---EQQTVTKLHQLL 1156
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 39.3 bits (90), Expect = 0.014
Identities = 56/288 (19%), Positives = 121/288 (42%), Gaps = 38/288 (13%)
Query: 7 LQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDD 66
LQQ+D + + +L +++ + + +L Q + E ND+ F +L
Sbjct: 1887 LQQMDGR--NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGK 1944
Query: 67 QYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQ 126
+ R LQ ++R ++ Q + + +K+E++ LE Q
Sbjct: 1945 EIVR--------LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQ 1996
Query: 127 SGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNG 186
+T + K++EL+ ++ +K +E E+ LE Q+E + K + ++ +
Sbjct: 1997 LMREFNTQLAQKEQELEMTIKETINKAQEVEAEL--LESHQEETNQLLKKIAEKDDDLKR 2054
Query: 187 VAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSA 246
AK ++ +LD + +E+ K+ +L E Q +++++ +
Sbjct: 2055 TAKRYEE-----------ILDAREEEMTAKVRDLQTQLEELQK--------KYQQKLEQE 2095
Query: 247 CIGGPPNACLDQLQNWF----TIVAESL---QQVRQQLKKLEELEQKY 287
G N + +LQ T++++S Q+ R+Q+ LE+ +KY
Sbjct: 2096 ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKY 2143
>gi|217035164 coiled-coil domain containing 27 [Homo sapiens]
Length = 656
Score = 38.9 bits (89), Expect = 0.018
Identities = 41/206 (19%), Positives = 95/206 (46%), Gaps = 16/206 (7%)
Query: 6 ELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQ-DWEHAANDVSFATIRFHDLLSQL 64
E +++ + + + +++ ++ +Y L+ Q + E S AT L Q+
Sbjct: 391 EEEEIPRRRASSLAESFEEELLAQLEEYEQVILDFQFNLEATRTRYSLATGVIASLQQQV 450
Query: 65 DDQYSRFSLEN--NFLLQHNIRKSKRNLQ------DNFQEDPIQMSMIIYSCLKEERKIL 116
D Q ++ N N LQ +R+ ++ LQ N +ED M+ ++++ ++L
Sbjct: 451 DFQETQLRKINTENETLQKELRERRQQLQAMTDKFSNLREDKKHQEMM--GLIEKDNQLL 508
Query: 117 ENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKT 176
Q+ ++ + + ++ ELD+KV ++++V ++ ++ + LQ++ K +
Sbjct: 509 R--QQVSELERKLTKRDCVIS---ELDTKVSQLQEQVELDQNHLQRWKQLQEDLQSKKEM 563
Query: 177 LQNREHETNGVAKSDQKQEQLLLKKM 202
+Q E T +S Q + + L K+
Sbjct: 564 IQQAEQHTRVALESSQSRLERLRNKI 589
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 38.5 bits (88), Expect = 0.023
Identities = 59/304 (19%), Positives = 124/304 (40%), Gaps = 34/304 (11%)
Query: 39 EKQDWEHAAND-VSFATIRFHDLLSQLDDQYSRFSLENNFLLQH--NIRKSKRNLQDNFQ 95
E QD + ND VSFA++ +L + ++ + L + ++ +QD Q
Sbjct: 778 EVQDLKAKQNDQVSFASL-VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 96 EDPIQMSMIIYSCLKEE--RKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKV 153
E LKEE LE AQ+ + ++ K++++++ +++K
Sbjct: 837 E---------IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE 887
Query: 154 MCIEHEIKSLEDLQDEYD-FKCKTLQNREHETNGVAKSDQ--------KQEQLLLKKMYL 204
+ + K L+DLQ+E + K + +H + + Q K+++ LK++
Sbjct: 888 KDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEA 947
Query: 205 MLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACL-------- 256
ML + ++ K L +V + +N L ++ + K++ PP+ L
Sbjct: 948 MLKERESDLSSKTQLLQDVQD--ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
Query: 257 DQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSS 316
++ + + V Q KK +L +K + + +++L D+ ++ Q
Sbjct: 1006 KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQV 1065
Query: 317 FVVE 320
VE
Sbjct: 1066 EAVE 1069
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 38.5 bits (88), Expect = 0.023
Identities = 59/304 (19%), Positives = 124/304 (40%), Gaps = 34/304 (11%)
Query: 39 EKQDWEHAAND-VSFATIRFHDLLSQLDDQYSRFSLENNFLLQH--NIRKSKRNLQDNFQ 95
E QD + ND VSFA++ +L + ++ + L + ++ +QD Q
Sbjct: 778 EVQDLKAKQNDQVSFASL-VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 96 EDPIQMSMIIYSCLKEE--RKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKV 153
E LKEE LE AQ+ + ++ K++++++ +++K
Sbjct: 837 E---------IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE 887
Query: 154 MCIEHEIKSLEDLQDEYD-FKCKTLQNREHETNGVAKSDQ--------KQEQLLLKKMYL 204
+ + K L+DLQ+E + K + +H + + Q K+++ LK++
Sbjct: 888 KDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEA 947
Query: 205 MLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACL-------- 256
ML + ++ K L +V + +N L ++ + K++ PP+ L
Sbjct: 948 MLKERESDLSSKTQLLQDVQD--ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
Query: 257 DQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSS 316
++ + + V Q KK +L +K + + +++L D+ ++ Q
Sbjct: 1006 KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQV 1065
Query: 317 FVVE 320
VE
Sbjct: 1066 EAVE 1069
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 38.5 bits (88), Expect = 0.023
Identities = 61/284 (21%), Positives = 127/284 (44%), Gaps = 31/284 (10%)
Query: 29 EIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLE------NNFLLQHN 82
E++Q Q +K+ E ++ A ++ +L ++L Q ++ + E +LQ+N
Sbjct: 963 ELKQSSEQ--KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 83 IRKSK---RNLQDNF--QEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLD 137
KS+ + LQ +F +E + + ++E+ + + N+ Q GN +
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 138 KQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQL 197
K + + + K K ++ K+L+D+Q E K K L N + + + + +QE+
Sbjct: 1081 KTAKATLEQDSAK-KEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
Query: 198 LLKKMYLMLDNKRKEVVHKIIELLNVTELTQ-NALINDELVEWKRRQQSACIGGPPNACL 256
+ K L+ + K HK+ + +T L L+ + +E + + S A +
Sbjct: 1140 ITK-----LNEELKS--HKLESIKEITNLKDAKQLLIQQKLELQGKADSL------KAAV 1186
Query: 257 DQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV 300
+Q + I+ + +++ ++LKK E +K H I K K+V
Sbjct: 1187 EQEKRNQQILKDQVKKEEEELKK--EFIEKEAKLHSEI-KEKEV 1227
Score = 37.4 bits (85), Expect = 0.051
Identities = 60/263 (22%), Positives = 114/263 (43%), Gaps = 53/263 (20%)
Query: 74 ENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQST 133
E N LQ + + L+ N E Q ++ ++E++ L AQ + +++++
Sbjct: 568 EKNHTLQEQVTQLTEKLK-NQSESHKQAQENLHDQVQEQKAHLRAAQD----RVLSLETS 622
Query: 134 VMLDKQKELDSKVRNVKDKVMCIEHEIKS---------------LEDLQDEYDFKCKTLQ 178
V EL+S++ K+KV ++ +IK+ DLQ+ D LQ
Sbjct: 623 V-----NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 179 NREHETNGV--------AKSDQKQEQLL--------LKKMYLMLDNKRKEVVHKIIEL-- 220
+++ E N + AK KQE K+ YL L+ K +E+ +I +L
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 221 --LNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLK 278
L V + AL + + ++RQ + + QL+ IV+ + ++++ +
Sbjct: 738 DSLEVKASKEQALQDLQ----QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 279 KLEELEQKYTYEHDPITKNKQVL 301
LE ++QK T + + KQ+L
Sbjct: 794 ALESIKQKLTKQEE----EKQIL 812
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,375,765
Number of Sequences: 37866
Number of extensions: 1272148
Number of successful extensions: 4453
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 186
Number of HSP's that attempted gapping in prelim test: 4039
Number of HSP's gapped (non-prelim): 490
length of query: 750
length of database: 18,247,518
effective HSP length: 110
effective length of query: 640
effective length of database: 14,082,258
effective search space: 9012645120
effective search space used: 9012645120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.