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Search of human proteins with 62422577
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62422577 neurobeachin [Homo sapiens]
(2946 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62422577 neurobeachin [Homo sapiens] 5877 0.0
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho... 3588 0.0
gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens] 498 e-140
gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens] 498 e-140
gi|149944548 neurobeachin-like 2 [Homo sapiens] 468 e-131
gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens] 388 e-107
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 359 2e-98
gi|191252801 WDFY family member 4 [Homo sapiens] 324 7e-88
gi|54292123 lysosomal trafficking regulator [Homo sapiens] 314 7e-85
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 313 2e-84
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 313 2e-84
gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens] 103 2e-21
gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens] 103 2e-21
gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens] 103 2e-21
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 53 4e-06
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 48 1e-04
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 48 2e-04
gi|161019170 mucin 5AC [Homo sapiens] 47 3e-04
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens] 47 3e-04
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 47 4e-04
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 47 4e-04
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 47 4e-04
gi|32189425 WD repeat domain 69 [Homo sapiens] 46 5e-04
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 46 5e-04
gi|124028510 WD40-repeat protein upregulated in HCC isoform c [H... 46 6e-04
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H... 46 6e-04
gi|27436925 synoviolin 1 isoform a [Homo sapiens] 45 0.001
gi|89145413 short stature homeobox 2 isoform a [Homo sapiens] 45 0.001
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens] 45 0.001
gi|4502565 calpain, small subunit 1 [Homo sapiens] 45 0.001
>gi|62422577 neurobeachin [Homo sapiens]
Length = 2946
Score = 5877 bits (15246), Expect = 0.0
Identities = 2946/2946 (100%), Positives = 2946/2946 (100%)
Query: 1 MASEKPGPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLPAGM 60
MASEKPGPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLPAGM
Sbjct: 1 MASEKPGPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLPAGM 60
Query: 61 INPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITC 120
INPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITC
Sbjct: 61 INPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITC 120
Query: 121 MTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVD 180
MTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVD
Sbjct: 121 MTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVD 180
Query: 181 MLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSA 240
MLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSA
Sbjct: 181 MLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSA 240
Query: 241 AAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCL 300
AAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCL
Sbjct: 241 AAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCL 300
Query: 301 IVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHV 360
IVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHV
Sbjct: 301 IVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHV 360
Query: 361 NTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKS 420
NTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKS
Sbjct: 361 NTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKS 420
Query: 421 ESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQD 480
ESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQD
Sbjct: 421 ESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQD 480
Query: 481 VKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVA 540
VKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVA
Sbjct: 481 VKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVA 540
Query: 541 MQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILF 600
MQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILF
Sbjct: 541 MQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILF 600
Query: 601 NPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSS 660
NPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSS
Sbjct: 601 NPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSS 660
Query: 661 GITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIH 720
GITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIH
Sbjct: 661 GITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIH 720
Query: 721 DVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKR 780
DVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKR
Sbjct: 721 DVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKR 780
Query: 781 KVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQ 840
KVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQ
Sbjct: 781 KVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQ 840
Query: 841 NPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLG 900
NPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLG
Sbjct: 841 NPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLG 900
Query: 901 YINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAK 960
YINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAK
Sbjct: 901 YINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAK 960
Query: 961 MYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPV 1020
MYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPV
Sbjct: 961 MYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPV 1020
Query: 1021 STDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPET 1080
STDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPET
Sbjct: 1021 STDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPET 1080
Query: 1081 LVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEDLP 1140
LVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEDLP
Sbjct: 1081 LVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEDLP 1140
Query: 1141 NSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTS 1200
NSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTS
Sbjct: 1141 NSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTS 1200
Query: 1201 SIIEEKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETESSSSKIVPNIDAGSI 1260
SIIEEKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETESSSSKIVPNIDAGSI
Sbjct: 1201 SIIEEKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETESSSSKIVPNIDAGSI 1260
Query: 1261 ISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQF 1320
ISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQF
Sbjct: 1261 ISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQF 1320
Query: 1321 SPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVH 1380
SPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVH
Sbjct: 1321 SPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVH 1380
Query: 1381 NTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMA 1440
NTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMA
Sbjct: 1381 NTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMA 1440
Query: 1441 MVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHG 1500
MVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHG
Sbjct: 1441 MVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHG 1500
Query: 1501 SSKPQEVPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQA 1560
SSKPQEVPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQA
Sbjct: 1501 SSKPQEVPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQA 1560
Query: 1561 QFLALAVVYFISVLMVSKYRDILEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHP 1620
QFLALAVVYFISVLMVSKYRDILEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHP
Sbjct: 1561 QFLALAVVYFISVLMVSKYRDILEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHP 1620
Query: 1621 SLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEE 1680
SLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEE
Sbjct: 1621 SLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEE 1680
Query: 1681 QVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKG 1740
QVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKG
Sbjct: 1681 QVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKG 1740
Query: 1741 INVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPP 1800
INVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPP
Sbjct: 1741 INVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPP 1800
Query: 1801 GSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGA 1860
GSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGA
Sbjct: 1801 GSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGA 1860
Query: 1861 TSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQ 1920
TSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQ
Sbjct: 1861 TSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQ 1920
Query: 1921 ELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVR 1980
ELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVR
Sbjct: 1921 ELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVR 1980
Query: 1981 VANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLK 2040
VANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLK
Sbjct: 1981 VANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLK 2040
Query: 2041 QKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIE 2100
QKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIE
Sbjct: 2041 QKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIE 2100
Query: 2101 YGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQL 2160
YGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQL
Sbjct: 2101 YGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQL 2160
Query: 2161 IAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRY 2220
IAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRY
Sbjct: 2161 IAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRY 2220
Query: 2221 LLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLY 2280
LLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLY
Sbjct: 2221 LLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLY 2280
Query: 2281 KSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNF 2340
KSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNF
Sbjct: 2281 KSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNF 2340
Query: 2341 RDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFL 2400
RDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFL
Sbjct: 2341 RDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFL 2400
Query: 2401 NANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEV 2460
NANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEV
Sbjct: 2401 NANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEV 2460
Query: 2461 VVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHY 2520
VVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHY
Sbjct: 2461 VVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHY 2520
Query: 2521 LTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFK 2580
LTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFK
Sbjct: 2521 LTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFK 2580
Query: 2581 DQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPG 2640
DQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPG
Sbjct: 2581 DQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPG 2640
Query: 2641 YSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDK 2700
YSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDK
Sbjct: 2641 YSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDK 2700
Query: 2701 SFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHII 2760
SFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHII
Sbjct: 2701 SFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHII 2760
Query: 2761 GDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGP 2820
GDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGP
Sbjct: 2761 GDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGP 2820
Query: 2821 ENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTG 2880
ENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTG
Sbjct: 2821 ENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTG 2880
Query: 2881 GDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHY 2940
GDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHY
Sbjct: 2881 GDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHY 2940
Query: 2941 EHQNRY 2946
EHQNRY
Sbjct: 2941 EHQNRY 2946
>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
containing [Homo sapiens]
Length = 2863
Score = 3588 bits (9303), Expect = 0.0
Identities = 1870/2980 (62%), Positives = 2234/2980 (74%), Gaps = 200/2980 (6%)
Query: 36 GTGGSGMGELRGASGSGSVMLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETV 95
G G G G + G++ L P +PIR IRMKFAVL GL++VGEVSNRDIVETV
Sbjct: 15 GDDGGGGGREETPTEGGALSL-----KPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETV 69
Query: 96 LNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTST 155
NLLVGG+FDLEMNFIIQ+ ESI CM +LLE CD+TCQAE+WSMFTAIL+KS+RNLQ T
Sbjct: 70 FNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCT 129
Query: 156 EVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVK 215
EVGL+E+VL K+ VD+MIADLLVDMLGVLASY++TV+ELKL FS L+G+ G WP HA K
Sbjct: 130 EVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGRWPPHAGK 189
Query: 216 LLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDK 275
LLSVL MPQ++GPD FFNFPG SAAAIALPPIAKWPYQNGFT +TW RMDP+NNINVDK
Sbjct: 190 LLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDK 249
Query: 276 DKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYN 335
DKPYLYCFRTSKG+GYSAHFVG CLIVTS+KSKGKGFQHCVK+DF+P+KWYM++IVHIYN
Sbjct: 250 DKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYN 309
Query: 336 RWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSE 395
RW+NSE+RCYVNG+L SYG++ W VNT+D++DKCFLGSSETADANRVFCGQ+ AVY+FSE
Sbjct: 310 RWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSE 369
Query: 396 ALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQ 455
ALN AQIFAI+QLG GYK TFKFK+ESD+ LAEHHK +LYDGKL+S+IAFTYN +ATDAQ
Sbjct: 370 ALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQ 429
Query: 456 LCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLN 515
LCLESSPK+N SIFVHSPHALMLQDVKA++THSI SA+HSIGG+QVLFPLFAQLD RQ
Sbjct: 430 LCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYL 489
Query: 516 DSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFL 575
+++ T+C+TLLAF++ELLK+S+AMQEQML KGFLVIGY LEKSS+ H++RAVLE L
Sbjct: 490 SDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCL 549
Query: 576 SFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIR 635
+F+KYL L +G PLLKQLCDH+L NPAIWIHTPAKVQL LYTYLS EFIGT IY TIR
Sbjct: 550 AFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIR 609
Query: 636 RVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKD 695
RVGTVL +MHTLKYYYW +NP D SGITPKGLDGPRP+QKE++SLRAF+L+F+KQL++KD
Sbjct: 610 RVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKD 669
Query: 696 RGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLA 755
GVKEDELQ+ILNYLLTMHED+N+ DVLQLLVALMSEHP SMIPAFDQRNG+RVIYKLLA
Sbjct: 670 SGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNGLRVIYKLLA 729
Query: 756 SKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYE 815
SKSE I VQALK +GYFLKHL KRK E+M H LF+LL ERLML TN +T+TTYN L+E
Sbjct: 730 SKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFE 789
Query: 816 ILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKL 875
IL EQ+ TQV+HK HP+PDS+VKIQNP ILKV+ATLL+NS E MEVRR FLSDMIKL
Sbjct: 790 ILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKL 849
Query: 876 FSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGW 935
F+NSRENRR LLQCSVWQ+WM SL Y NPKNS+EQKITEMVY IFRILLYHA+KYEWGGW
Sbjct: 850 FNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGW 909
Query: 936 RVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAK 995
RVWVDTLSI HSKVT+E HKE LA ++ E Q + +E I +V SG+
Sbjct: 910 RVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIR------- 962
Query: 996 GGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDL 1055
R+I SQ P+++ D PV + + + + S ++E+
Sbjct: 963 -----RDINVSVGSQQPDTK-DSPVCPH----FTTNGNENSSIEKTSSLESASNIELQTT 1012
Query: 1056 LVDIKAEKVEATEVKLDDMDLSPETLVGGENGA--------LVEVESLLDNVYSAAVEKL 1107
+ K E +L D ETL A ++E ++ N + K
Sbjct: 1013 NTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSF-ITTGKD 1071
Query: 1108 QNNVHGSVGIIKKNEEKDNGPLITLADE---KEDLPNSSTSFLFDKIPKQEEKLLPELSS 1164
V I E+D + D+ +E+ + + P +E L EL
Sbjct: 1072 SMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQD 1131
Query: 1165 NHIIPNIQDTQVHLGV--SDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHT-TSDGMSSIS 1221
N + P + L + +DD + + + + K+ I T T+ G S++S
Sbjct: 1132 NSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMS 1191
Query: 1222 ----------ERDLASSTKGLEYAEMTATTLET-----------ESSSSKIVPNIDAGSI 1260
E DL + E + T T ET E+SS + + +D ++
Sbjct: 1192 PETTVSQIAVESDLGQMLE--EGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNV 1249
Query: 1261 ISDTER----SDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQ 1316
+DTER + E+ + R + + G+ I Q
Sbjct: 1250 ATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPD--------------AVNGQ 1295
Query: 1317 RRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENI 1376
RR R+T+FRIPEF WS MHQRLLTDLLF++ETD+ +WRSHSTK+VMDFVNS++N+
Sbjct: 1296 RRD----SRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNV 1351
Query: 1377 IFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLS 1436
IFVHNTIHLISQ++DN+++ACGGILPLLSAATS T ELENIE TQG+S E +VTFL
Sbjct: 1352 IFVHNTIHLISQVMDNMVMACGGILPLLSAATSAT---HELENIEPTQGLSIEASVTFLQ 1408
Query: 1437 RLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQ--RDRG 1494
RL+++VDVL+FASSL F+EIEAEK+MSSGG++RQCLRLVC VAVRNCLEC+Q + RG
Sbjct: 1409 RLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRG 1468
Query: 1495 NKSSHGSSKPQE--VPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFR 1552
+K + KP +P +A+K+P++ V G +SP++D DRLLQD+DINRLRAVVFR
Sbjct: 1469 DK----ALKPMHSLIP---LGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFR 1521
Query: 1553 DVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRE-----TTRTGSQPGRNIRQEINSP 1607
D++DSKQAQFLALAVVYFISVLMVSKYRDILEPQ E T TGS+ N+
Sbjct: 1522 DIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSE-NENV------- 1573
Query: 1608 TSTVVVIPSIPHPSLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVE 1667
S + TPAAF T E+ +
Sbjct: 1574 -------------------------------SLSEITPAAFSTL-----TTASVEESEST 1597
Query: 1668 SSIPHTDSGIGEEQVASILNGAELE-------TSTGPDAMSELLSTLSSEVKKSQESLTE 1720
SS DSGIGEE + + E+ S GPDA+SE+LSTLS EV KS E+ +
Sbjct: 1598 SSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKND 1657
Query: 1721 NPSETLKPATSISSISQTKGINVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAIL 1780
++ AT S+S +K +NVK+IL+SLV P + P +P +
Sbjct: 1658 RGNDLDTKAT--PSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQ 1715
Query: 1781 PMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTT 1840
P+QF SFDRSV+V KK + V +T + +PT + S + S +++
Sbjct: 1716 PVQFRSFDRSVIVAAKK--------SAVSPSTFNTSIPTNAVSVV---------SSVDSA 1758
Query: 1841 GAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLR 1900
A D G S S SS + LP+V TV + +D NMSIT +LE ALEK APLLR
Sbjct: 1759 QASDMGGESPGSRSS------NAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLR 1812
Query: 1901 EIFVDFAPFLSRTLLGSHGQELLIEG--LVCMKSSTSVVELVMLLCSQEWQNSIQKNAGL 1958
EIFVDFAPFLSRTLLGSHGQELLIEG LVCMKSS+SVVELVMLLCSQEWQNSIQKNAGL
Sbjct: 1813 EIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGL 1872
Query: 1959 AFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEE 2018
AFIEL+NEGRLL MKDH+VRVANEAEFIL+RQRAED+H+HAEFES CAQY+AD+RE+E
Sbjct: 1873 AFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDE 1932
Query: 2019 KMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRR 2078
KMCDHLI AAK+RDHVTA QL QKI+NILT+KHGAWG + S+ +FWRLDYWEDDLRRR
Sbjct: 1933 KMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRR 1992
Query: 2079 RRFVRNAFGSTHAEALLKAAIEY-----------GTEEDVV-KSKKTFRSQAIVNQNAET 2126
RRFVRN GSTH EA LK A+E+ T+ED++ K K++ RSQA+ NQN+E
Sbjct: 1993 RRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSEN 2052
Query: 2127 ELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDD 2186
E++LEGDDD +S + EK+++NLAGPV LSTPAQL+AP VV KGTLS+T++E+YFEVDE+D
Sbjct: 2053 EILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEED 2112
Query: 2187 SAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQAT 2246
FKKID K+LAYTEGLHGKW+F+EIR++FSRRYLLQNTALE+FMANR +VMFNFPD AT
Sbjct: 2113 PNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPAT 2172
Query: 2247 VKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTI 2306
VKKVV LPRVGVGTS+GLPQ RRISLA+PRQL+K+SNMTQRWQ REISNFEYLMFLNTI
Sbjct: 2173 VKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTI 2232
Query: 2307 AGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWE 2366
AGR+YNDLNQYPVFPWV+TNYESEELDLTLP NFRDLSKPIGALNPKRA F+AERYE+WE
Sbjct: 2233 AGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWE 2292
Query: 2367 DDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQR 2426
DDQ P +HY THYSTA+ L+WL+RIEPFTT+FLN GKFDH DRTFSS++R+WR SQR
Sbjct: 2293 DDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQR 2352
Query: 2427 DTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALE 2486
DTSD+KELIPEFYYLPEMFVN N YNLGV +D VV+DV+LPPWAK E+FV INR+ALE
Sbjct: 2353 DTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALE 2412
Query: 2487 SEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQ 2546
SEFVSCQLHQWIDLIFGYKQ+GPEAVRALNVF+YLTYEG+VNL+SITDPVLREA+EAQI+
Sbjct: 2413 SEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIR 2472
Query: 2547 NFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANT 2606
+FGQTPSQLLIEPHPPR SAM + SPLMF D+ QQDVIMVLKFPSNSPVTHVAANT
Sbjct: 2473 SFGQTPSQLLIEPHPPRGSAMQV-----SPLMFTDKAQQDVIMVLKFPSNSPVTHVAANT 2527
Query: 2607 LPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKR 2666
P L PAV+TVT +RLFAVN+WHN +GA DQ + LP+E+DPLIA+N+G+++R
Sbjct: 2528 QPGLATPAVITVTANRLFAVNKWHNLPAHQGA---VQDQPYQLPVEIDPLIASNTGMHRR 2584
Query: 2667 QITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCL 2726
QITDL+DQSIQ+++ CFV+T+DNRYIL+CGFWDKSFRVYST+TG+L Q+VFGHWDVVTCL
Sbjct: 2585 QITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCL 2644
Query: 2727 ARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCV 2786
ARSESYIGG+CYI+SGSRDATLLLWYW+G+ IGDNP S+ APRA+LTGHD+EV C
Sbjct: 2645 ARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNP-GSETAAPRAILTGHDYEVTCA 2703
Query: 2787 SVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRF 2846
+VCAELGLV+SG++EGPCL+H++ GDLLR LEGPENCL P+LI S EGHC+I+YE G F
Sbjct: 2704 AVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLF 2763
Query: 2847 SNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAG 2906
FS+NGKL A ME +D+ RAI LS DGQ L+TGGD GVV V Q D KQL+ YPGCDAG
Sbjct: 2764 CTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAG 2823
Query: 2907 IRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY 2946
IRAM LS+DQR +I+GMASGSIV F DFNRWH+E+Q RY
Sbjct: 2824 IRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY 2863
>gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]
Length = 2694
Score = 498 bits (1283), Expect = e-140
Identities = 357/1054 (33%), Positives = 530/1054 (50%), Gaps = 89/1054 (8%)
Query: 1876 EDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELL-----IEGLVCM 1930
E+ E I KLE L + EI+ P L RTL+ S ELL + L
Sbjct: 1606 ENQDEACYILGKLEHVLSQSIKEQTEIYSFLIP-LVRTLV-SKIYELLFMNLHLPSLPFT 1663
Query: 1931 KSSTSVVELVMLLC-SQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVA------N 1983
S+S E C S EWQ I+K + +++ H D +A
Sbjct: 1664 NGSSSFFEDFQEYCNSNEWQVYIEKYI-VPYMKQYE-----AHTFYDGHENMALYWKDCY 1717
Query: 1984 EAEFI-LNRQRAEDVHKHAEFESQCAQ-YAADRREEEKMCDHLISAAKHRDHVTANQLKQ 2041
EA + ++++ E +F+ + + R+E ++++ + T + K
Sbjct: 1718 EALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWKA 1777
Query: 2042 KILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALL---KAA 2098
I LT + G W + +H W+L E+ R R + V N TH EA
Sbjct: 1778 -IQLYLTCERGPWAKRKQNPIH--WKLANVENYSRMRLKLVPNYNFKTHEEASALRDNLG 1834
Query: 2099 IEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSL-LQEKEIDNLAGPVVLSTP 2157
I++ + + Q V+ E +L L +D + + EKE + +VL
Sbjct: 1835 IQHSQPSSDTLLLEVVK-QVKVSDMVEDKLDLPEEDITARVNVDEKEEQDQKEKLVLMED 1893
Query: 2158 AQLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFS 2217
+LI + V G L ITT IYF D + +K D G KW S+IR +
Sbjct: 1894 CELITIIDVIPGRLEITTQHIYFY----DGSIEKEDGV------GFDFKWPHSQIREIHL 1943
Query: 2218 RRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYS--LPRVGVGTSYGLPQARRISLAT 2275
RRY L+ +ALE+F ++++ NF + V+ +YS L + YG +
Sbjct: 1944 RRYNLRRSALEIFHVDQSNYFLNFKKE--VRNKIYSRLLSLHSPNSYYGS--------RS 1993
Query: 2276 PRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLT 2335
P++L+K+S +TQ+W REISNF+YL+ +NT+AGRTYNDL QYPVFPW+L +Y SEELDL
Sbjct: 1994 PQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLN 2053
Query: 2336 LPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSP--PYHYNTHYSTATSTLSWLVRIE 2393
P FRDLSKPIG +N K A E+YE +ED +HY THYS + + +L+R+E
Sbjct: 2054 NPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVE 2113
Query: 2394 PFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNL 2453
PFTT + G+FD DR F S+ +W+ + DVKELIPEF+Y PE N N +NL
Sbjct: 2114 PFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQNQFNL 2173
Query: 2454 G-VREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAV 2512
G ++ + +VNDV LP WAK EDF+ +R ALESE+VS LH+WIDLIFGYKQRGP AV
Sbjct: 2174 GRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAV 2233
Query: 2513 RALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFL 2572
ALNVF+Y +YEG+V+LD++TD R+A+E I NFGQTP QLL EPHPPR SA
Sbjct: 2234 EALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAVQK 2293
Query: 2573 P-----QSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVN 2627
P + +F+ + + P+ T+P + ++ L
Sbjct: 2294 PTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKA---TIPKNQYRSFMSQGSPELLITI 2350
Query: 2628 RWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTA 2687
+ +G G Y + +++ D + N +R I ++I + FVV+
Sbjct: 2351 SMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPK--TQRSINGSFAPGLEITSKLFVVSH 2408
Query: 2688 DNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDAT 2747
D + + G+WD S +V S GK+ + H D+VTCLA Y G +++SGSRD T
Sbjct: 2409 DAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLA--TDYCG--IHLISGSRDTT 2464
Query: 2748 LLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVH 2807
++W + + G P P +L GH +EV+ V + EL + +SG+++G ++H
Sbjct: 2465 CMIWQITQQ----GGVPVGL-ASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIH 2519
Query: 2808 TI-TGDLLRALEGP-ENCLFPRL--ISVSSEGHCIIY---------YERGRFSNFSINGK 2854
TI G +R L P E+ LF + +++S EGH ++Y ++ FSINGK
Sbjct: 2520 TIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGK 2579
Query: 2855 LLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEV 2888
L + + I + G+++VTG G + +
Sbjct: 2580 YLGSQILKEQVSDICII--GEHIVTGSIQGFLSI 2611
Score = 86.7 bits (213), Expect = 3e-16
Identities = 106/458 (23%), Positives = 184/458 (40%), Gaps = 86/458 (18%)
Query: 385 GQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIA 444
GQLG+V +F E L P Q+ A++ GP S +K + ESD+ L +I
Sbjct: 783 GQLGSVIIFYEPLQPPQVKALYLAGPNCLSPWKCQ-ESDM------------ADLPGNIL 829
Query: 445 FTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFP 504
Y AKA +CL+ S + H + + +V I I+ IGG+ VLFP
Sbjct: 830 LYYTAKACKNSICLDLS--------TNCLHGRLTGN--KVVNWDIKDIINCIGGLNVLFP 879
Query: 505 LFAQLD-------------------------------NRQLNDSQVETTVCATLLAFLVE 533
L Q+ + + ++S++E + AT + +
Sbjct: 880 LLEQISHFSEGQIPEEKNESTVPESVTPVEGDWLVWTSTKASESRLERNLVATFILIVKH 939
Query: 534 LLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQ 593
++ Q ++ G +G LL+K + VL + + L LL+Q
Sbjct: 940 FIQRHPINQGNLIHSHGVATLGALLQKVPSTLMDVNVLMAVQLLIEQV-SLEKNMQLLQQ 998
Query: 594 LCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWV 653
+ ++LF+ IW ++ YLS + ++ R+ V L+ TL+ YY
Sbjct: 999 MYQYLLFDFRIWNRGDFPFRIGHIQYLSTIIKDSRRVF---RKKYGVQFLLDTLRIYY-- 1053
Query: 654 INPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTM 713
G S +I ++R + +K + K G +E+QSI+ Y+
Sbjct: 1054 ----------GNGCKYNELSLDDIRTIRTSLYGLIKYFLCK--GGSHEEIQSIMGYIAAT 1101
Query: 714 HEDENIHDVLQLLVALMSEHPAS---MIPAFDQRNGIRVIYKLLASKSES---------I 761
+E+E + +L +L +L+ P + F+ N ++Y LL ++ S I
Sbjct: 1102 NEEEQLFGILDVLFSLLRTSPTRGQLFLLLFEPGNA-DILYALLLNQKYSDRLREIIFKI 1160
Query: 762 WVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLM 799
Q LK + + H R E+ ++ L LL E L+
Sbjct: 1161 MEQMLKCTNVYERSKQHIRLREVGYS-GLGLLLNEALV 1197
Score = 62.8 bits (151), Expect = 5e-09
Identities = 64/269 (23%), Positives = 121/269 (44%), Gaps = 16/269 (5%)
Query: 118 ITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGL-IEQVLLKMSAVDDMIAD 176
I + EL H D+ W + + R + +G+ I + L S++ A+
Sbjct: 451 IQWLPELQSH-DLQIFISDWLKRICCINRQSRTTCVNANMGIRIIETLDLHSSLHQTCAE 509
Query: 177 LLVDMLGVLASYSITVKELKLLFSMLR-GESGIWPRHAVKLLSVLNQMPQRHGPDT---F 232
L+ + G L S S++ +E++ L +LR ES + + + M ++ ++ +
Sbjct: 510 NLIAIHGSLGSQSVSSEEIRRLLRLLRVDESESVHPYVTPVTRAILTMARKLSLESALQY 569
Query: 233 FNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMD----PLNNINVDKDKPYLYCFRTSKG 288
FN S A I++PPI KWP + F+ + WF +D L N + LY F T G
Sbjct: 570 FNLSH-SMAGISVPPIQKWP-GSAFSFSAWFCLDQDQLTLGIANKGGKRKQLYSFFTGSG 627
Query: 289 VGYSAHFVGNCLIVTSLKSKGK-GFQHCVKYDFQPRKWYMISIVHIYNR--WRNSEIRCY 345
+G+ A + ++V ++ +K + + F W+ I++VH+ + + S + Y
Sbjct: 628 MGFEAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLWHNITVVHMPGKRPFGQSFVYIY 687
Query: 346 VNGQLVSYGDMAWHVNTNDSYDKCFLGSS 374
NGQ + + N+ + C +GS+
Sbjct: 688 DNGQQKVSAPLRFPA-MNEPFTSCCIGSA 715
>gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]
Length = 1404
Score = 498 bits (1283), Expect = e-140
Identities = 357/1054 (33%), Positives = 530/1054 (50%), Gaps = 89/1054 (8%)
Query: 1876 EDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELL-----IEGLVCM 1930
E+ E I KLE L + EI+ P L RTL+ S ELL + L
Sbjct: 316 ENQDEACYILGKLEHVLSQSIKEQTEIYSFLIP-LVRTLV-SKIYELLFMNLHLPSLPFT 373
Query: 1931 KSSTSVVELVMLLC-SQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVA------N 1983
S+S E C S EWQ I+K + +++ H D +A
Sbjct: 374 NGSSSFFEDFQEYCNSNEWQVYIEKYI-VPYMKQYE-----AHTFYDGHENMALYWKDCY 427
Query: 1984 EAEFI-LNRQRAEDVHKHAEFESQCAQ-YAADRREEEKMCDHLISAAKHRDHVTANQLKQ 2041
EA + ++++ E +F+ + + R+E ++++ + T + K
Sbjct: 428 EALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWKA 487
Query: 2042 KILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALL---KAA 2098
I LT + G W + +H W+L E+ R R + V N TH EA
Sbjct: 488 -IQLYLTCERGPWAKRKQNPIH--WKLANVENYSRMRLKLVPNYNFKTHEEASALRDNLG 544
Query: 2099 IEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSL-LQEKEIDNLAGPVVLSTP 2157
I++ + + Q V+ E +L L +D + + EKE + +VL
Sbjct: 545 IQHSQPSSDTLLLEVVK-QVKVSDMVEDKLDLPEEDITARVNVDEKEEQDQKEKLVLMED 603
Query: 2158 AQLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFS 2217
+LI + V G L ITT IYF D + +K D G KW S+IR +
Sbjct: 604 CELITIIDVIPGRLEITTQHIYFY----DGSIEKEDGV------GFDFKWPHSQIREIHL 653
Query: 2218 RRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYS--LPRVGVGTSYGLPQARRISLAT 2275
RRY L+ +ALE+F ++++ NF + V+ +YS L + YG +
Sbjct: 654 RRYNLRRSALEIFHVDQSNYFLNFKKE--VRNKIYSRLLSLHSPNSYYGS--------RS 703
Query: 2276 PRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLT 2335
P++L+K+S +TQ+W REISNF+YL+ +NT+AGRTYNDL QYPVFPW+L +Y SEELDL
Sbjct: 704 PQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLN 763
Query: 2336 LPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSP--PYHYNTHYSTATSTLSWLVRIE 2393
P FRDLSKPIG +N K A E+YE +ED +HY THYS + + +L+R+E
Sbjct: 764 NPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVE 823
Query: 2394 PFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNL 2453
PFTT + G+FD DR F S+ +W+ + DVKELIPEF+Y PE N N +NL
Sbjct: 824 PFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQNQFNL 883
Query: 2454 G-VREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAV 2512
G ++ + +VNDV LP WAK EDF+ +R ALESE+VS LH+WIDLIFGYKQRGP AV
Sbjct: 884 GRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAV 943
Query: 2513 RALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFL 2572
ALNVF+Y +YEG+V+LD++TD R+A+E I NFGQTP QLL EPHPPR SA
Sbjct: 944 EALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAVQK 1003
Query: 2573 P-----QSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVN 2627
P + +F+ + + P+ T+P + ++ L
Sbjct: 1004 PTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKA---TIPKNQYRSFMSQGSPELLITI 1060
Query: 2628 RWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTA 2687
+ +G G Y + +++ D + N +R I ++I + FVV+
Sbjct: 1061 SMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPK--TQRSINGSFAPGLEITSKLFVVSH 1118
Query: 2688 DNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDAT 2747
D + + G+WD S +V S GK+ + H D+VTCLA Y G +++SGSRD T
Sbjct: 1119 DAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLA--TDYCG--IHLISGSRDTT 1174
Query: 2748 LLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVH 2807
++W + + G P P +L GH +EV+ V + EL + +SG+++G ++H
Sbjct: 1175 CMIWQITQQ----GGVPVGL-ASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIH 1229
Query: 2808 TI-TGDLLRALEGP-ENCLFPRL--ISVSSEGHCIIY---------YERGRFSNFSINGK 2854
TI G +R L P E+ LF + +++S EGH ++Y ++ FSINGK
Sbjct: 1230 TIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGK 1289
Query: 2855 LLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEV 2888
L + + I + G+++VTG G + +
Sbjct: 1290 YLGSQILKEQVSDICII--GEHIVTGSIQGFLSI 1321
>gi|149944548 neurobeachin-like 2 [Homo sapiens]
Length = 2754
Score = 468 bits (1203), Expect = e-131
Identities = 308/868 (35%), Positives = 447/868 (51%), Gaps = 96/868 (11%)
Query: 2066 WRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQ--- 2122
W+L E R R + V N H EA A + E + +++ A+ +
Sbjct: 1827 WKLSSAETYSRMRLKLVPNHHFDPHLEA--SALRDNLGEVPLTPTEEASLPLAVTKEAKV 1884
Query: 2123 NAETELMLE---GDDDAVSL---LQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTT 2176
+ EL+ E G+D+ L ++ E+D +VLS QL+ V V G L +TT
Sbjct: 1885 STPPELLQEDQLGEDELAELETPMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQ 1944
Query: 2177 EIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWM--FSEIRAVFSRRYLLQNTALEVFMANR 2234
+YF D + ++++T+ EG+ + +++R V RR+ L+ +ALE+F ++
Sbjct: 1945 NVYFY----DGSTERVETE-----EGIGYDFRRPLAQLREVHLRRFNLRRSALELFFIDQ 1995
Query: 2235 TSVMFNFPDQATVKKVVY--SLPRVGVGTSYGLPQARR----------------ISLATP 2276
+ NFP + V PR G Q R +S +P
Sbjct: 1996 ANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSP 2055
Query: 2277 RQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTL 2336
+++ ++S +TQ+W +REISNFEYLM LNTIAGRTYNDL+QYPVFPWVL +Y S LDL+
Sbjct: 2056 QEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSN 2115
Query: 2337 PGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSP--PYHYNTHYSTATSTLSWLVRIEP 2394
P FRDLSKPIG +NPK A E+YE++ED +HY THYS A + +L+R+EP
Sbjct: 2116 PAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMHYLIRVEP 2175
Query: 2395 FTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLG 2454
FT+ + G+FD DR F SVA +W+ +DVKELIPEF+Y P+ N NG++LG
Sbjct: 2176 FTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFDLG 2235
Query: 2455 VRE-DEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVR 2513
+ V DV LPPWA PEDF++ +R ALESE+VS LH+WIDLIFGYKQRGP A
Sbjct: 2236 CLQLTNEKVGDVVLPPWASSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEE 2295
Query: 2514 ALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLC--- 2570
ALNVF+Y TYEG+V+LD +TD R+A+E I NFGQTP QLL EPHP R SA
Sbjct: 2296 ALNVFYYCTYEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLSAEEAAHRL 2355
Query: 2571 ------------FLPQSPLMFKDQMQQDVIMVLKF-PSNSPVTHVAANTLPHLTIPAVVT 2617
L + F + + V +VL P P + + + P L +VT
Sbjct: 2356 ARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQPHSFITQGS-PDL----LVT 2410
Query: 2618 VTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQ 2677
V+ S L + W Y + +++ DP + ++ +R ++
Sbjct: 2411 VSASGLLGTHSW---------LPYDRNISNYFSFSKDPTMGSHK--TQRLLSGPWVPGSG 2459
Query: 2678 INAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDC 2737
++ V D + + G WD S RV + GKL + H DVVTCLA I
Sbjct: 2460 VSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGI---- 2515
Query: 2738 YIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVIS 2797
Y++SGSRD T ++W + + + P P VL GH V CV++ EL + +S
Sbjct: 2516 YLISGSRDTTCMVWRLLHQGGL-----SVGLAPKPVQVLYGHGAAVSCVAISTELDMAVS 2570
Query: 2798 GAKEGPCLVHTITGDLLRALEGPENCLFPRLI---SVSSEGHCIIY---YERG------R 2845
G+++G ++HT+ A P FP I ++ SEG ++ +ER
Sbjct: 2571 GSEDGTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGSEGQIVVQSSAWERPGAQVTYS 2630
Query: 2846 FSNFSINGKLLAQMEINDSTRAILLSSD 2873
+S+NGKL A + + + A+ ++ D
Sbjct: 2631 LHLYSVNGKLRASLPLAEQPTALTVTED 2658
Score = 63.5 bits (153), Expect = 3e-09
Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 24/243 (9%)
Query: 153 TSTEVGLIEQVLLKMS---AVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRG----- 204
T + GL+ +L +S A++ + L+ +L L SI EL+ L G
Sbjct: 488 TCVQAGLVGCLLETLSTGLALEARCQEQLLALLQALGRVSIRPMELRHLLRPRPGLDSEP 547
Query: 205 ---ESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGC--SAAAIALPPIAKWPYQNGFTL 259
E+G RHA ++ L+ M + GP + S A I +PP+ +WP GFT
Sbjct: 548 GGAEAGK-ARHAGAVIRTLSGMARHQGPARALRYFDLTPSMAGIMVPPVQRWP-GPGFTF 605
Query: 260 NTWFRMDPLNNINVDK-----DKPYLYCFRTSKGVGYSAHF-VGNCLIVTSLKSKGKGFQ 313
+ W + P++ + LY F TS G G+ A F L+V K
Sbjct: 606 HAWLCLHPMDTAPTPAPTRPLQRKQLYSFFTSSGSGFEAFFTAAGTLVVAVCTRKEYLTM 665
Query: 314 HCVKYDFQPRKWYMISIVHIYNR--WRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFL 371
+ F W+ ++IVH+ R + + + Y +G LV + + ++ + C +
Sbjct: 666 SLPEVSFADSAWHCVAIVHVPGRRPFSQNLVHVYKDGHLVKTAPLRC-PSLSEPFSSCCI 724
Query: 372 GSS 374
GS+
Sbjct: 725 GSA 727
Score = 61.2 bits (147), Expect = 1e-08
Identities = 86/383 (22%), Positives = 148/383 (38%), Gaps = 80/383 (20%)
Query: 385 GQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIA 444
G+LGAV +F EAL + + LGP T FK E ++H +L++ +
Sbjct: 801 GELGAVAIFHEALQATALRTLCTLGP--NETAPFKPEGELH------------ELSTRLL 846
Query: 445 FTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFP 504
Y+ +A +CL+ SP + + H + DVK +V + +GG+ L P
Sbjct: 847 LHYSPQACKNNICLDLSPSHGLDGRL-TGHRVETWDVKDVV--------NCVGGMGALLP 897
Query: 505 LFAQ---------------------------------LDNRQLNDSQVETTVCATLLAFL 531
L + L + ++ ++E A L L
Sbjct: 898 LLERVAAQPKEAEAGPAETHDLVGPELTSGHNTQGLVLPLGKSSEERMERNAVAAFLLML 957
Query: 532 VELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLL 591
L+ + QE ++ +G +IG LL K + VL + + G PLL
Sbjct: 958 RNFLQGHMVNQESLVQCQGPAIIGALLRKVPSWAMDMNVLMSAQLLMEQVAAEGSG-PLL 1016
Query: 592 KQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYY 651
L H+LFN +W + V+L Y+S+ +R+ V ++ L+ +Y
Sbjct: 1017 YLLYQHLLFNFHLWTLSDFAVRLGHIQYMSSI---VREHRQKLRKKYGVQFILDALRTHY 1073
Query: 652 WVINPADSSGITPKGLDGPRPSQKEIISL-RAFMLLFLKQLILKDRGVKEDEL---QSIL 707
P D R Q ++ L R F++ R + D++ Q++L
Sbjct: 1074 ------SPQRERPLAADDLRTVQTSLLGLAREFLV----------RSLSADDVQVTQTML 1117
Query: 708 NYLLTMHEDENIHDVLQLLVALM 730
++L +D L LL+AL+
Sbjct: 1118 SFLAATGDDGQAVGALDLLLALL 1140
>gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]
Length = 1335
Score = 388 bits (996), Expect = e-107
Identities = 265/704 (37%), Positives = 373/704 (52%), Gaps = 55/704 (7%)
Query: 1876 EDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELL-----IEGLVCM 1930
E+ E I KLE L + EI+ P L RTL+ S ELL + L
Sbjct: 316 ENQDEACYILGKLEHVLSQSIKEQTEIYSFLIP-LVRTLV-SKIYELLFMNLHLPSLPFT 373
Query: 1931 KSSTSVVELVMLLC-SQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVA------N 1983
S+S E C S EWQ I+K + +++ H D +A
Sbjct: 374 NGSSSFFEDFQEYCNSNEWQVYIEKYI-VPYMKQYE-----AHTFYDGHENMALYWKDCY 427
Query: 1984 EAEFI-LNRQRAEDVHKHAEFESQCAQ-YAADRREEEKMCDHLISAAKHRDHVTANQLKQ 2041
EA + ++++ E +F+ + + R+E ++++ + T + K
Sbjct: 428 EALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLKQLSSQQLATLRRWKA 487
Query: 2042 KILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALL---KAA 2098
I LT + G W + +H W+L E+ R R + V N TH EA
Sbjct: 488 -IQLYLTCERGPWAKRKQNPIH--WKLANVENYSRMRLKLVPNYNFKTHEEASALRDNLG 544
Query: 2099 IEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSL-LQEKEIDNLAGPVVLSTP 2157
I++ + + Q V+ E +L L +D + + EKE + +VL
Sbjct: 545 IQHSQPSSDTLLLEVVK-QVKVSDMVEDKLDLPEEDITARVNVDEKEEQDQKEKLVLMED 603
Query: 2158 AQLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFS 2217
+LI + V G L ITT IYF D + +K D G KW S+IR +
Sbjct: 604 CELITIIDVIPGRLEITTQHIYFY----DGSIEKEDGV------GFDFKWPHSQIREIHL 653
Query: 2218 RRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYS--LPRVGVGTSYGLPQARRISLAT 2275
RRY L+ +ALE+F ++++ NF + V+ +YS L + YG +
Sbjct: 654 RRYNLRRSALEIFHVDQSNYFLNFKKE--VRNKIYSRLLSLHSPNSYYGS--------RS 703
Query: 2276 PRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLT 2335
P++L+K+S +TQ+W REISNF+YL+ +NT+AGRTYNDL QYPVFPW+L +Y SEELDL
Sbjct: 704 PQELFKASGLTQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLN 763
Query: 2336 LPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSP--PYHYNTHYSTATSTLSWLVRIE 2393
P FRDLSKPIG +N K A E+YE +ED +HY THYS + + +L+R+E
Sbjct: 764 NPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVE 823
Query: 2394 PFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNL 2453
PFTT + G+FD DR F S+ +W+ + DVKELIPEF+Y PE N N +NL
Sbjct: 824 PFTTLHIQLQSGRFDCADRQFHSIPATWQALMDNPYDVKELIPEFFYFPEFLENQNQFNL 883
Query: 2454 G-VREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAV 2512
G ++ + +VNDV LP WAK EDF+ +R ALESE+VS LH+WIDLIFGYKQRGP AV
Sbjct: 884 GRLQISKELVNDVILPKWAKSAEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAV 943
Query: 2513 RALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLL 2556
ALNVF+Y +YEG+V+LD++TD R+A+E I NFGQTP QLL
Sbjct: 944 EALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLL 987
Score = 113 bits (282), Expect = 3e-24
Identities = 80/282 (28%), Positives = 135/282 (47%), Gaps = 26/282 (9%)
Query: 2620 CSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQIN 2679
C L + +G G Y + +++ D + N +R I ++I
Sbjct: 984 CQLLKITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPK--TQRSINGSFAPGLEIT 1041
Query: 2680 AHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYI 2739
+ FVV+ D + + G+WD S +V S GK+ + H D+VTCLA Y G ++
Sbjct: 1042 SKLFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLA--TDYCG--IHL 1097
Query: 2740 VSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGA 2799
+SGSRD T ++W + + G P P +L GH +EV+ V + EL + +SG+
Sbjct: 1098 ISGSRDTTCMIWQITQQ----GGVPVGL-ASKPFQILYGHTNEVLSVGISTELDMAVSGS 1152
Query: 2800 KEGPCLVHTI-TGDLLRALEGP-ENCLFPRL--ISVSSEGHCIIY---------YERGRF 2846
++G ++HTI G +R L P E+ LF + +++S EGH ++Y ++
Sbjct: 1153 RDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNAL 1212
Query: 2847 SNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEV 2888
FSINGK L + + I + G+++VTG G + +
Sbjct: 1213 HLFSINGKYLGSQILKEQVSDICII--GEHIVTGSIQGFLSI 1252
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 359 bits (922), Expect = 2e-98
Identities = 219/561 (39%), Positives = 313/561 (55%), Gaps = 35/561 (6%)
Query: 2209 FSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYS-----LPRVGVGTSY 2263
+ +I+ V RRYLLQ A+EVF + + + F Q ++ VY +P + +
Sbjct: 2611 YEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAF--QKGIRNKVYQRFLAVVPSLTDSSES 2668
Query: 2264 GLPQARRISLATPRQLYKS----SNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPV 2319
Q S+ L + ++TQRW+R EISNF+YLM LNT+AGR+YNDL QYPV
Sbjct: 2669 VSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPV 2728
Query: 2320 FPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWED--DQSPPYHYNT 2377
FPW+L +Y+SEE+DLT P FR+L+KP+GA +R Y +RY+ WED ++P YHY T
Sbjct: 2729 FPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGT 2788
Query: 2378 HYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSW-RTSQRDTSDVKELIP 2436
HYS+A S+LVR+EPFT FL G FD DR F SV +W S+ + +DVKELIP
Sbjct: 2789 HYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIP 2848
Query: 2437 EFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLH 2495
EF+YLPE NSN ++LG +++ + DV LPPWAK P +F+R++R ALE ++VS LH
Sbjct: 2849 EFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLH 2908
Query: 2496 QWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQL 2555
+WIDLIFGYKQ+GP AV A+NVFH+L YEG V++ +I DP+ A I NFGQ P QL
Sbjct: 2909 EWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQL 2968
Query: 2556 LIEPHPPRSSAMHL----CFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHL- 2610
+PHPP+ L + P D++ + L+ PS +PV + +
Sbjct: 2969 FKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLR-PSLTPVKELKEPVGQIVC 3027
Query: 2611 TIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITD 2670
T ++ V +++ W+ T A GY+ L + ++ + +++
Sbjct: 3028 TDKGILAVEQNKVLIPPTWNKTF----AWGYA-----DLSCRLGTYESDKAMTVYECLSE 3078
Query: 2671 LVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSE 2730
I + +V ++C W+ +T L Q + GH D VTC S
Sbjct: 3079 WGQILCAICPNPKLVITGGTSTVVC-VWEMGTSKEKAKTVTLKQALLGHTDTVTCATASL 3137
Query: 2731 SYIGGDCYIVSGSRDATLLLW 2751
+Y IVSGSRD T ++W
Sbjct: 3138 AY----HIIVSGSRDRTCIIW 3154
Score = 46.2 bits (108), Expect = 5e-04
Identities = 65/346 (18%), Positives = 125/346 (36%), Gaps = 65/346 (18%)
Query: 324 KWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKC----------FLGS 373
+W+ + +V +NS Y++GQLV+ + + +T ++G+
Sbjct: 1192 QWHHLVLVMSKGMLKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGT 1251
Query: 374 SETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFK--------FKSE---- 421
+LG + E L + + I++LGP Y +F+ KSE
Sbjct: 1252 PPAQRQIASLVWRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVP 1311
Query: 422 SDIHLAEHHK----------------------QVLYDGKLASSIAFTYNAKATDAQLCLE 459
S + L K L +A + + + AT +L
Sbjct: 1312 SPVSLVPEEKVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHN 1371
Query: 460 SSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQV 519
S+ N S + V+ V + + + +GG + L A + + + V
Sbjct: 1372 SAGHLNGSARTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAV 1431
Query: 520 ETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAK 579
+ VC ++KS+ ++M KG+ ++ LL+K R + +L S
Sbjct: 1432 KALVC---------VVKSNPLASKEMERIKGYQLLAMLLKK-KRSLLNSHILHLTFSLVG 1481
Query: 580 YLDG------LSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTY 619
+D + + LCD +W+H P ++ LSL+ +
Sbjct: 1482 TVDSGHETSIIPNSTAFQDLLCDF-----EVWLHAPYELHLSLFEH 1522
>gi|191252801 WDFY family member 4 [Homo sapiens]
Length = 3184
Score = 324 bits (831), Expect = 7e-88
Identities = 217/579 (37%), Positives = 302/579 (52%), Gaps = 70/579 (12%)
Query: 2209 FSEIRAVFSRRYLLQNTALEVFMANRTS---VMFNFPDQATVKKVVYSLPRV-GVGTSYG 2264
++++R + R+LLQ+ ALE+F N S V +N K P + G TS
Sbjct: 2465 YADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSED 2524
Query: 2265 LPQARRISLATPRQLYKSSN--MTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPW 2322
RR Y S+ M Q+WQ+R+ISNFEYLM+LNT AGRT ND QYPVFPW
Sbjct: 2525 TLSLRR---------YPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPW 2575
Query: 2323 VLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERY---ETWEDDQSPPYHYNTHY 2379
VL +Y SE L+L P FRDLSKP+GA +R + + +R+ E E D + HY THY
Sbjct: 2576 VLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHY 2635
Query: 2380 STATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDT-SDVKELIPEF 2438
S+A S+LVR+ PFT F G FD DR F SV +W ++ R+ SDV+EL PEF
Sbjct: 2636 SSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEF 2695
Query: 2439 YYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLHQW 2497
+YLPE N NG G +D V+ DV LPPWA P F+ ++R ALES+FVS LH W
Sbjct: 2696 FYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHW 2755
Query: 2498 IDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLI 2557
IDLIFGYKQ+GP AV A+N+FH Y ++L SITDP+++ + + NFGQ P QL
Sbjct: 2756 IDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFT 2815
Query: 2558 EPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVT 2617
+PHP R++A PL K DV + P + + +L P+ VT
Sbjct: 2816 KPHPARTAA-------GKPLPGK-----DVSTPVSLPGHPQPFFYSLQSLR----PSQVT 2859
Query: 2618 VTCSRLFAVNRWHNTVGLRGAPGYSLD-QAHHLPIEMDPLI------------------- 2657
V LF++ + +GA G+ + + L +E + ++
Sbjct: 2860 VKDMYLFSL----GSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCC 2915
Query: 2658 ANNSGVNKRQIT--DLVDQSIQINAHC---FVVTADNRYILICGFWDKSFRVYSTETGKL 2712
+ G +K +T +L + A C + ++C W+ S +L
Sbjct: 2916 LGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVC-VWELSMTKGRPRGLRL 2974
Query: 2713 TQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW 2751
Q ++GH VTCLA S ++ +VSGS+D T +LW
Sbjct: 2975 RQALYGHTQAVTCLAASVTF----SLLVSGSQDCTCILW 3009
Score = 40.8 bits (94), Expect = 0.020
Identities = 65/267 (24%), Positives = 118/267 (44%), Gaps = 44/267 (16%)
Query: 386 QLGAVYVFSEALNPAQIFAIHQLGPGYKSTFK--------FKSESDIHLAEHHKQVLYDG 437
+LG Y+F EA++ + I++LGP Y F+ SE+ +AE ++V +
Sbjct: 1233 RLGPTYLFEEAISMETLEVINKLGPRYCGNFQAVHVQGEDLDSEATPFVAE--ERVSFGL 1290
Query: 438 KLASS----IAFTYNA-KATDAQLCLES---SPKENAS-IFV------HSPHALMLQDVK 482
+ASS +A NA D++L + S ++NA +F+ H +L
Sbjct: 1291 HIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAV 1350
Query: 483 AI------VTHS--IHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVEL 534
A+ V HS S++ IGG +L L + + + V+ L +
Sbjct: 1351 AVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKV---------LHSV 1401
Query: 535 LKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLD-GLSHGAPLLKQ 593
L S+ M G+ ++ +LL K + + + + + LS A ++ G A
Sbjct: 1402 LTSNAMCDFLMQHICGYQIMAFLLRKKASL-LNHRIFQLILSVAGTVELGFRSSAITNTG 1460
Query: 594 LCDHILFNPAIWIHTPAKVQLSLYTYL 620
+ HIL N +W++T ++LSL+++L
Sbjct: 1461 VFQHILCNFELWMNTADNLELSLFSHL 1487
Score = 40.4 bits (93), Expect = 0.026
Identities = 33/143 (23%), Positives = 58/143 (40%), Gaps = 12/143 (8%)
Query: 2773 RAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVS 2832
R L GH V C++ L++SG+++ C++ + L P + I++S
Sbjct: 2975 RQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDL-DHLTHVTRLPAHREGISAITIS 3033
Query: 2833 SEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLS---------SDGQNLVTGGDN 2883
I+ S +++NG+ LA + + Q ++TG +
Sbjct: 3034 DVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQD 3093
Query: 2884 GVVEVWQACDFKQLYIYPGCDAG 2906
G+V VW+ D K PG AG
Sbjct: 3094 GMVRVWKTEDVKM--SVPGRPAG 3114
>gi|54292123 lysosomal trafficking regulator [Homo sapiens]
Length = 3801
Score = 314 bits (805), Expect = 7e-85
Identities = 274/1002 (27%), Positives = 461/1002 (46%), Gaps = 139/1002 (13%)
Query: 1981 VANEAEFILNR--QRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQ 2038
V N + + R +++D+ K A +Q + E +K+ H+ ++ ++A++
Sbjct: 2865 VNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGN-ERKKVIQHI--RGMYKVDLSASR 2921
Query: 2039 LKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAA 2098
Q+++ LT+ W + W+LD E R RRR R + + + LL+
Sbjct: 2922 HWQELIQQLTHDRAVWYDPIYYPTS--WQLDPTEGPNRERRRLQR-CYLTIPNKYLLR-- 2976
Query: 2099 IEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPA 2158
+ EDVVK ++ + + + + + + +++ + +
Sbjct: 2977 -DRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRR---------------C 3020
Query: 2159 QLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSR 2218
+AP G L + +YF ED+++ + + E W + EI+ V R
Sbjct: 3021 ISVAPSRETAGELLLGKCGMYFV--EDNASDTVESSSLQGELEPASFSWTYEEIKEVHKR 3078
Query: 2219 RYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQ 2278
+ L++ A+E+F+ N +++ F D V+ VY + T+ LP T
Sbjct: 3079 WWQLRDNAVEIFLTNGRTLLLAF-DNTKVRDDVYH----NILTN-NLPNLLEYGNITA-- 3130
Query: 2279 LYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPG 2338
+T W +I+NFEYL LN AGR++NDL QYPVFP++L +Y SE LDL
Sbjct: 3131 ------LTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLL 3184
Query: 2339 NFRDLSKPIGALNPKRAVFYAERYE---------TWEDDQSP---PYHYNTHYSTATSTL 2386
+R+LSKPI ++ Y + Y+ EDD P PYHY +HYS + + L
Sbjct: 3185 IYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVL 3244
Query: 2387 SWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDT-SDVKELIPEFYYLPEMF 2445
+LVR+ PFT FL D FD PDRTF S +WR S ++ +DVKELIPEF+YLPE
Sbjct: 3245 HFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFL 3304
Query: 2446 VNSNGYNLGVREDEVVVNDVDLPPWAKK-PEDFVRINRMALESEFVSCQLHQWIDLIFGY 2504
VN G++ GVR++ VN V+LPPWA+ P F+ I+R ALES++VS + QWIDL+FGY
Sbjct: 3305 VNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGY 3364
Query: 2505 KQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRS 2564
KQ+G +V+A+NVFH TY G +++ ++ DPV R A+E I+ +GQTP QL H R
Sbjct: 3365 KQKGKASVQAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSR- 3422
Query: 2565 SAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLF 2624
P + L + ++ V ++++F V T P S L
Sbjct: 3423 --------PGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYP------------SPLS 3462
Query: 2625 AVN--RWHNTVGLRGAP----------GYSLDQAHHLPIEMDPLIANN----------SG 2662
+ +W VG AP G LP ++ N G
Sbjct: 3463 WIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQG 3522
Query: 2663 VNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFG--HW 2720
V TD IQ +A IL G+ D R+ S ++ + +
Sbjct: 3523 VRSMNSTD-----IQWSA-----------ILSWGYADNILRLKSKQSEPPVNFIQSSQQY 3566
Query: 2721 DVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHD 2780
V +C +++ C + +GS+ + + + P+ + + L GH
Sbjct: 3567 QVTSC-----AWVPDSCQLFTGSKCGVITAY----TNRFTSSTPSEIEMET-QIHLYGHT 3616
Query: 2781 HEVVCVSVCAELGLVISGAKEGPCLVHTITG-DLLRALEGPENCLFPRLISVSSEGHCII 2839
E+ + VC ++IS +++G C++ + +++L G ++ + S +S +
Sbjct: 3617 EEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATV 3676
Query: 2840 YYERGRFSN---FSINGKLLAQMEINDSTRAILLSSDGQ----NLVTGG-DNGVVEVWQA 2891
G S+ +++NG L+ + + ++ S+ + N++ GG +NG+V +W
Sbjct: 3677 CDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWST 3736
Query: 2892 CDFKQL--YIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAF 2931
D K + +P + I ++ S D L T + G+++A+
Sbjct: 3737 WDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
>gi|31543297 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 1 [Homo sapiens]
Length = 917
Score = 313 bits (801), Expect = 2e-84
Identities = 245/849 (28%), Positives = 401/849 (47%), Gaps = 87/849 (10%)
Query: 2102 GTEEDVVKSKKTFRSQAIVNQNAETELMLEG---DDDAVSLLQEKEIDNLAGPVVLSTPA 2158
G EDVV++ + +++ + M+ A + + N++ + + A
Sbjct: 141 GKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKA 200
Query: 2159 QLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSR 2218
+++ P+V G + IT T +YF+ V+ T ++R ++ R
Sbjct: 201 EMVTPLVTNPGHVCITDTNLYFQ------PLNGYPKPVVQIT--------LQDVRRIYKR 246
Query: 2219 RYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQ 2278
R+ L LEVF D + + + P+ + + +A
Sbjct: 247 RHGLMPLGLEVFCTE--------DDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAE--- 295
Query: 2279 LYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPG 2338
+ + + +WQR +SN++YL+ LN +A R+ NDL+QYPVFPW++ +Y S ELDL+ PG
Sbjct: 296 -HTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPG 354
Query: 2339 NFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTF 2398
FRDLSKP+GALN +R RY+ + P + Y +HYS+ L +LVRI P +
Sbjct: 355 TFRDLSKPVGALNKERLERLLTRYQEMPE---PKFMYGSHYSSPGYVLFYLVRIAP--EY 409
Query: 2399 FLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMF-VNSNGYNLGVRE 2457
L +G+FD+ DR F+S+A +W+ +D KELIPEFY F VNS +LG R+
Sbjct: 410 MLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQ 469
Query: 2458 DEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNV 2517
+V+DV+LPPWA PEDF++ ++ ALES +VS LH+WIDLIFGYKQ+G +AV A NV
Sbjct: 470 GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNV 529
Query: 2518 FHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPR---------SSAMH 2568
FH LTYEG V+L+SI DP + AM QI FGQTP QL + PHP R ++ +
Sbjct: 530 FHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSY 589
Query: 2569 LCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNR 2628
+ SP ++ +D+ K + + +T + + + AV +T SR
Sbjct: 590 NASMADSP---GEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSR------ 640
Query: 2629 WHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTAD 2688
G+ ++ Q L + + S + +R I+ S + C ++ D
Sbjct: 641 -------NGSSVFTTSQDSTL-----KMFSKESKMLQRSIS----FSNMALSSCLLLPGD 684
Query: 2689 NRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATL 2748
+I WD + YS G+ + GH D V+ + D + S S D+T+
Sbjct: 685 --ATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKIC------WHDNRLYSASWDSTV 736
Query: 2749 LLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHT 2808
+ WSG + + P + + HD V +S+ A L++SG KEG +
Sbjct: 737 KV--WSG---VPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWD 791
Query: 2809 I-TGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSI-NGKLLAQMEINDSTR 2866
+ T L+ + + S S H + G + + G L++ M ++ R
Sbjct: 792 LTTATLMHQIPCHSGIVCDTAFSPDSR-HVLSTGTDGCLNVIDVQTGMLISSMTSDEPQR 850
Query: 2867 AILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASG 2926
+ DG ++++G +G + VW K G + + ++ ++ITG
Sbjct: 851 CFVW--DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDR 908
Query: 2927 SIVAFNIDF 2935
I+ + + +
Sbjct: 909 QIIFWKLQY 917
>gi|221625547 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 2 [Homo sapiens]
Length = 948
Score = 313 bits (801), Expect = 2e-84
Identities = 245/849 (28%), Positives = 401/849 (47%), Gaps = 87/849 (10%)
Query: 2102 GTEEDVVKSKKTFRSQAIVNQNAETELMLEG---DDDAVSLLQEKEIDNLAGPVVLSTPA 2158
G EDVV++ + +++ + M+ A + + N++ + + A
Sbjct: 172 GKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKA 231
Query: 2159 QLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSR 2218
+++ P+V G + IT T +YF+ V+ T ++R ++ R
Sbjct: 232 EMVTPLVTNPGHVCITDTNLYFQ------PLNGYPKPVVQIT--------LQDVRRIYKR 277
Query: 2219 RYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQ 2278
R+ L LEVF D + + + P+ + + +A
Sbjct: 278 RHGLMPLGLEVFCTE--------DDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAE--- 326
Query: 2279 LYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPG 2338
+ + + +WQR +SN++YL+ LN +A R+ NDL+QYPVFPW++ +Y S ELDL+ PG
Sbjct: 327 -HTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPG 385
Query: 2339 NFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTF 2398
FRDLSKP+GALN +R RY+ + P + Y +HYS+ L +LVRI P +
Sbjct: 386 TFRDLSKPVGALNKERLERLLTRYQEMPE---PKFMYGSHYSSPGYVLFYLVRIAP--EY 440
Query: 2399 FLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMF-VNSNGYNLGVRE 2457
L +G+FD+ DR F+S+A +W+ +D KELIPEFY F VNS +LG R+
Sbjct: 441 MLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQ 500
Query: 2458 DEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNV 2517
+V+DV+LPPWA PEDF++ ++ ALES +VS LH+WIDLIFGYKQ+G +AV A NV
Sbjct: 501 GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNV 560
Query: 2518 FHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPR---------SSAMH 2568
FH LTYEG V+L+SI DP + AM QI FGQTP QL + PHP R ++ +
Sbjct: 561 FHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSY 620
Query: 2569 LCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNR 2628
+ SP ++ +D+ K + + +T + + + AV +T SR
Sbjct: 621 NASMADSP---GEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSR------ 671
Query: 2629 WHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTAD 2688
G+ ++ Q L + + S + +R I+ S + C ++ D
Sbjct: 672 -------NGSSVFTTSQDSTL-----KMFSKESKMLQRSIS----FSNMALSSCLLLPGD 715
Query: 2689 NRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATL 2748
+I WD + YS G+ + GH D V+ + D + S S D+T+
Sbjct: 716 --ATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKIC------WHDNRLYSASWDSTV 767
Query: 2749 LLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHT 2808
+ WSG + + P + + HD V +S+ A L++SG KEG +
Sbjct: 768 KV--WSG---VPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWD 822
Query: 2809 I-TGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSI-NGKLLAQMEINDSTR 2866
+ T L+ + + S S H + G + + G L++ M ++ R
Sbjct: 823 LTTATLMHQIPCHSGIVCDTAFSPDSR-HVLSTGTDGCLNVIDVQTGMLISSMTSDEPQR 881
Query: 2867 AILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASG 2926
+ DG ++++G +G + VW K G + + ++ ++ITG
Sbjct: 882 CFVW--DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDR 939
Query: 2927 SIVAFNIDF 2935
I+ + + +
Sbjct: 940 QIIFWKLQY 948
>gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 103 bits (258), Expect = 2e-21
Identities = 96/299 (32%), Positives = 127/299 (42%), Gaps = 50/299 (16%)
Query: 2289 WQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLP-GNFRDLSKPI 2347
W ISNF YLM LN +AGR D N +PV PWV+ D T P G FRDL K
Sbjct: 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRDLRKSK 403
Query: 2348 GALNP--KRAVFYAER----YETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLN 2401
LN K+ F E + P H H S S +++ V T +
Sbjct: 404 FRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSVL 463
Query: 2402 ANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVV 2461
+ + + S Q T D E IPEFY P +F R
Sbjct: 464 CGHVRAQWEPHEYPA---SMERMQNWTPD--ECIPEFYTDPSIF----------RSIHPD 508
Query: 2462 VNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYL 2521
+ D+D+P W ++FV +R LES VS LH WIDL FGYK +G EAV+ NV +L
Sbjct: 509 MPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHL 568
Query: 2522 TYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFK 2580
+D+ T + ++G QL +PHP R + P+ PL+ K
Sbjct: 569 -------VDAHT----------HLASYGVV--QLFDQPHPQRLAGAP-ALAPEPPLIPK 607
>gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 2240
Score = 103 bits (258), Expect = 2e-21
Identities = 96/299 (32%), Positives = 127/299 (42%), Gaps = 50/299 (16%)
Query: 2289 WQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLP-GNFRDLSKPI 2347
W ISNF YLM LN +AGR D N +PV PWV+ D T P G FRDL K
Sbjct: 651 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRDLRKSK 702
Query: 2348 GALNP--KRAVFYAER----YETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLN 2401
LN K+ F E + P H H S S +++ V T +
Sbjct: 703 FRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSVL 762
Query: 2402 ANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVV 2461
+ + + S Q T D E IPEFY P +F R
Sbjct: 763 CGHVRAQWEPHEYPA---SMERMQNWTPD--ECIPEFYTDPSIF----------RSIHPD 807
Query: 2462 VNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYL 2521
+ D+D+P W ++FV +R LES VS LH WIDL FGYK +G EAV+ NV +L
Sbjct: 808 MPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHL 867
Query: 2522 TYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFK 2580
+D+ T + ++G QL +PHP R + P+ PL+ K
Sbjct: 868 -------VDAHT----------HLASYGVV--QLFDQPHPQRLAGAP-ALAPEPPLIPK 906
>gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 103 bits (258), Expect = 2e-21
Identities = 96/299 (32%), Positives = 127/299 (42%), Gaps = 50/299 (16%)
Query: 2289 WQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLP-GNFRDLSKPI 2347
W ISNF YLM LN +AGR D N +PV PWV+ D T P G FRDL K
Sbjct: 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV--------DFTTPHGRFRDLRKSK 403
Query: 2348 GALNP--KRAVFYAER----YETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLN 2401
LN K+ F E + P H H S S +++ V T +
Sbjct: 404 FRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSVL 463
Query: 2402 ANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVV 2461
+ + + S Q T D E IPEFY P +F R
Sbjct: 464 CGHVRAQWEPHEYPA---SMERMQNWTPD--ECIPEFYTDPSIF----------RSIHPD 508
Query: 2462 VNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYL 2521
+ D+D+P W ++FV +R LES VS LH WIDL FGYK +G EAV+ NV +L
Sbjct: 509 MPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHL 568
Query: 2522 TYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFK 2580
+D+ T + ++G QL +PHP R + P+ PL+ K
Sbjct: 569 -------VDAHT----------HLASYGVV--QLFDQPHPQRLAGAP-ALAPEPPLIPK 607
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 53.1 bits (126), Expect = 4e-06
Identities = 53/212 (25%), Positives = 96/212 (45%), Gaps = 30/212 (14%)
Query: 2692 ILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW 2751
+L G D +++ +TG L + GH DVV L+ + S G +VS SRD TL +W
Sbjct: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPS---GSLILVSASRDKTLRIW 181
Query: 2752 YWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITG 2811
+ + + VL+GH V C S+ + ++ S A E + ++
Sbjct: 182 -------------DLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRS 228
Query: 2812 -DLLRALEGPE----NCLF----PRLISVSSEGHCIIY----YERGRFSNFSINGKLLAQ 2858
L+R LEG + +C F L++ S + + I++ ER R + + +
Sbjct: 229 YTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDD 288
Query: 2859 MEIN-DSTRAILLSSDGQNLVTGGDNGVVEVW 2889
+++ S R++ S +G L T D+ ++ +W
Sbjct: 289 SDVHISSLRSVCFSPEGLYLATVADDRLLRIW 320
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 48.1 bits (113), Expect = 1e-04
Identities = 69/260 (26%), Positives = 106/260 (40%), Gaps = 71/260 (27%)
Query: 2684 VVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGS 2743
V+++D ++ L G WD + R++ TG T+ GH V +A S + IVSGS
Sbjct: 70 VISSDGQFAL-SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD----NRQIVSGS 124
Query: 2744 RDATLLLWYWSG--------RHH-----IIGDNPNSSD--------------YPAPRAVL 2776
RD T+ LW G H + +PNSS+ + L
Sbjct: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
Query: 2777 ----TGHDHEVVCVSVCAELGLVISGAKEGPCLV-------HTIT---GDLLRALEGPEN 2822
GH + V+V + L SG K+G ++ H T GD++ AL
Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL----- 239
Query: 2823 CLFP-RLISVSSEGHCIIYYERGRFSNFSINGKL----LAQMEINDSTRA-------ILL 2870
C P R ++ G I ++ + GK+ L Q I+ S++A +
Sbjct: 240 CFSPNRYWLCAATGPSIKIWD--------LEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291
Query: 2871 SSDGQNLVTGGDNGVVEVWQ 2890
S+DGQ L G + +V VWQ
Sbjct: 292 SADGQTLFAGYTDNLVRVWQ 311
Score = 38.5 bits (88), Expect = 0.099
Identities = 49/241 (20%), Positives = 99/241 (41%), Gaps = 21/241 (8%)
Query: 2707 TETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNS 2766
TE L + GH VT +A + + I+S SRD T+++W + +
Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPD---MILSASRDKTIIMWKLTR---------DE 49
Query: 2767 SDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPC-LVHTITGDLLRALEGPENCLF 2825
++Y P+ L GH H V V + ++ +SG+ +G L TG R G +
Sbjct: 50 TNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVL 109
Query: 2826 PRLISVSSEGHCIIYYERGR----FSNFSINGKLLAQMEINDSTRAILLSSDGQN--LVT 2879
++ SS+ I+ R + ++ + + ++ + S + N +V+
Sbjct: 110 S--VAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVS 167
Query: 2880 GGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWH 2939
G + +V+VW + K + G + + +S D +G G + ++++ +
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227
Query: 2940 Y 2940
Y
Sbjct: 228 Y 228
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 47.8 bits (112), Expect = 2e-04
Identities = 62/275 (22%), Positives = 113/275 (41%), Gaps = 34/275 (12%)
Query: 2664 NKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVV 2723
+ + IT L + + N C V + ++ D S R++ T G+ +I+ GH V
Sbjct: 198 HSKWITGLSWEPLHANPECRYVASSSK--------DGSVRIWDTTAGRCERILTGHTQSV 249
Query: 2724 TCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEV 2783
TCL GGD + S S+D T+ +W + D R L GH H V
Sbjct: 250 TCLR-----WGGDGLLYSASQDRTIKVW-------------RAHDGVLCR-TLQGHGHWV 290
Query: 2784 VCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYER 2843
+++ + L +GA E P DL +L+ + R V +G +
Sbjct: 291 NTMALSTDYAL-RTGAFE-PAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGS 348
Query: 2844 GRFSNF----SINGKLLAQMEINDS-TRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLY 2898
F+ F + + K L +M + + +L S D + + + + +++W K L
Sbjct: 349 DDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLA 408
Query: 2899 IYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNI 2933
G A + + S D R L++G + ++ +++
Sbjct: 409 SLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
>gi|161019170 mucin 5AC [Homo sapiens]
Length = 6207
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/187 (28%), Positives = 81/187 (43%), Gaps = 12/187 (6%)
Query: 1692 ETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLV 1751
+T+T MS + + + E + LT + T + +S S+ S T G IL L
Sbjct: 4813 QTTTPVATMSTIHPSSTPETTHTSTVLTTKATTT-RATSSTSTPSSTPGTTW--ILTELT 4869
Query: 1752 AAPVEIAECGPEPIPYPDPALKRE-TQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGA 1810
A A GP P P T+ + S P PG+ + T +
Sbjct: 4870 TAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATP--SSTPGTTWILTEPS 4927
Query: 1811 TTAGSGLPTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAV 1868
TTA +PTGST+ + AT TP ++TT + +SS ++ SS AT+ LPA+
Sbjct: 4928 TTATVTVPTGSTATASSTQATAGTPH--VSTTATTPTVTSSKATPSSSPGTATA--LPAL 4983
Query: 1869 QTVAPMP 1875
++ A P
Sbjct: 4984 RSTATTP 4990
Score = 38.9 bits (89), Expect = 0.076
Identities = 56/240 (23%), Positives = 86/240 (35%), Gaps = 46/240 (19%)
Query: 1644 TPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEEQVASILNGAELETSTGPDAMSEL 1703
TP A +P + V +S + + S G T T P+ +
Sbjct: 3614 TPTATSSKATSSSSPRTATTLPVLTSTATKSTATSFTPIPSFTLGT---TGTLPEQTTTP 3670
Query: 1704 LSTLSSEVKKSQESLTENPS------ETLKPATSISSISQTKGINVKEILKSLVAAPVEI 1757
++T+S+ S T + T + +S+S+ S T G IL L A
Sbjct: 3671 MATMSTIHPSSTPETTHTSTVLTTKATTTRATSSMSTPSSTPGTTW--ILTELTTAATTT 3728
Query: 1758 AECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGL 1817
A GP P PG+ + T +TTA +
Sbjct: 3729 AATGPTATP------------------------------SSTPGTTWILTEPSTTATVTV 3758
Query: 1818 PTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMP 1875
PTGST+ + AT T K + +T SS ++ SSS T+ LPA+++ A P
Sbjct: 3759 PTGSTATASSTRATAGTLKVLTSTATTPTVISSRATPSSS---PGTATALPALRSTATTP 3815
Score = 37.4 bits (85), Expect = 0.22
Identities = 26/78 (33%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFV 1857
PG+ + T +TTA +PTGST+ + AT TP ++TT + + +SS ++ F
Sbjct: 3097 PGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPH--VSTTAT--TPTVTSSKATPFS 3152
Query: 1858 NGATSKNLPAVQTVAPMP 1875
+ T+ LPA+++ A P
Sbjct: 3153 SPGTATALPALRSTATTP 3170
Score = 37.4 bits (85), Expect = 0.22
Identities = 26/78 (33%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFV 1857
PG+ + T +TTA +PTGST+ + AT TP ++TT + + +SS ++ F
Sbjct: 4244 PGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPH--VSTTAT--TPTVTSSKATPFS 4299
Query: 1858 NGATSKNLPAVQTVAPMP 1875
+ T+ LPA+++ A P
Sbjct: 4300 SPGTATALPALRSTATTP 4317
Score = 35.0 bits (79), Expect = 1.1
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSN-IFAATGATPKSMINTTGAVDSGSSSSSSSSSFVN 1858
PG+ + T TTA + TGST+ A P ++ TT + +SS ++ SS
Sbjct: 2594 PGTTWILTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTSSKATPSSSPG 2653
Query: 1859 GATSKNLPAVQTVAPMP 1875
AT+ LPA+++ A P
Sbjct: 2654 TATA--LPALRSTATTP 2668
Score = 33.5 bits (75), Expect = 3.2
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNG 1859
PG+ + T TTA + TGST+ + G P + T+ A ++SS ++SS +
Sbjct: 4717 PGTTWILTELTTTATTTASTGSTATPSSTPGTAPPPKVLTSPATTPTATSSKATSS-SSP 4775
Query: 1860 ATSKNLPAVQTVA 1872
T+ LP + + A
Sbjct: 4776 RTATTLPVLTSTA 4788
Score = 32.3 bits (72), Expect = 7.1
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 3/74 (4%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFAATG-ATPKSMINTTGAVDSGSSSSSSSSSFVN 1858
PG+ + T T A + TGST+ + G A P ++ +T + +SS ++SSS
Sbjct: 3570 PGTTWILTEQTTAATTTATTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSSSSPR 3629
Query: 1859 GATSKNLPAVQTVA 1872
AT+ LP + + A
Sbjct: 3630 TATT--LPVLTSTA 3641
>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
Length = 5765
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/187 (28%), Positives = 81/187 (43%), Gaps = 12/187 (6%)
Query: 1692 ETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLV 1751
+T+T MS + + + E + LT + T + +S S+ S T G IL L
Sbjct: 4343 QTTTPVATMSTIHPSSTPETTHTSTVLTTKATTT-RATSSTSTPSSTPGTTW--ILTELT 4399
Query: 1752 AAPVEIAECGPEPIPYPDPALKRE-TQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGA 1810
A A GP P P T+ + S P PG+ + T +
Sbjct: 4400 TAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATP--SSTPGTTWILTEPS 4457
Query: 1811 TTAGSGLPTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAV 1868
TTA +PTGST+ + AT TP ++TT + +SS ++ SS AT+ LPA+
Sbjct: 4458 TTATVTVPTGSTATASSTQATAGTPH--VSTTATTPTVTSSKATPSSSPGTATA--LPAL 4513
Query: 1869 QTVAPMP 1875
++ A P
Sbjct: 4514 RSTATTP 4520
Score = 38.9 bits (89), Expect = 0.076
Identities = 56/240 (23%), Positives = 86/240 (35%), Gaps = 46/240 (19%)
Query: 1644 TPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEEQVASILNGAELETSTGPDAMSEL 1703
TP A +P + V +S + + S G T T P+ +
Sbjct: 3034 TPTATSSKATSSSSPRTATTLPVLTSTATKSTATSFTPIPSFTLGT---TGTLPEQTTTP 3090
Query: 1704 LSTLSSEVKKSQESLTENPS------ETLKPATSISSISQTKGINVKEILKSLVAAPVEI 1757
++T+S+ S T + T + +S+S+ S T G IL L A
Sbjct: 3091 MATMSTIHPSSTPETTHTSTVLTTKATTTRATSSMSTPSSTPGTTW--ILTELTTAATTT 3148
Query: 1758 AECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGL 1817
A GP P PG+ + T +TTA +
Sbjct: 3149 AATGPTATP------------------------------SSTPGTTWILTEPSTTATVTV 3178
Query: 1818 PTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMP 1875
PTGST+ + AT T K + +T SS ++ SSS T+ LPA+++ A P
Sbjct: 3179 PTGSTATASSTRATAGTLKVLTSTATTPTVISSRATPSSS---PGTATALPALRSTATTP 3235
Score = 37.4 bits (85), Expect = 0.22
Identities = 26/78 (33%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFV 1857
PG+ + T +TTA +PTGST+ + AT TP ++TT + + +SS ++ F
Sbjct: 2462 PGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPH--VSTTAT--TPTVTSSKATPFS 2517
Query: 1858 NGATSKNLPAVQTVAPMP 1875
+ T+ LPA+++ A P
Sbjct: 2518 SPGTATALPALRSTATTP 2535
Score = 37.4 bits (85), Expect = 0.22
Identities = 26/78 (33%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFA--ATGATPKSMINTTGAVDSGSSSSSSSSSFV 1857
PG+ + T +TTA +PTGST+ + AT TP ++TT + + +SS ++ F
Sbjct: 3719 PGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPH--VSTTAT--TPTVTSSKATPFS 3774
Query: 1858 NGATSKNLPAVQTVAPMP 1875
+ T+ LPA+++ A P
Sbjct: 3775 SPGTATALPALRSTATTP 3792
Score = 35.4 bits (80), Expect = 0.84
Identities = 67/327 (20%), Positives = 110/327 (33%), Gaps = 43/327 (13%)
Query: 1589 TTRTGSQPGRN-IRQEINSPTSTVVVIPSIPHPSLNHGFLAKL----------IPEQSFG 1637
T S PG I E+ + +T S PS G L +P S
Sbjct: 4411 TATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWILTEPSTTATVTVPTGSTA 4470
Query: 1638 HSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEEQVASILNGAELETSTGP 1697
+ + A P TPT SS P T + + A T+T P
Sbjct: 4471 TASSTQATAGTPHVSTTATTPTVTSSKATPSSSPGTATALP----------ALRSTATTP 4520
Query: 1698 DAMS-ELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLVAAPVE 1756
A S + + S ++ S T P+ T+ AT S+ V + A
Sbjct: 4521 TATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTATATTTGATGS 4580
Query: 1757 IAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPP--------PGSLAVTTV 1808
+A P P A + F + S PP P + TT
Sbjct: 4581 VAT----PSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTTTPTTS 4636
Query: 1809 GATTAGSGLP---------TGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNG 1859
G+T S +P T +T+ + + ATP S T+G S ++++++ ++ +
Sbjct: 4637 GSTVTPSSIPGTTHTARVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGST 4696
Query: 1860 ATSKNLPAVQTVAPMPEDSAENMSITA 1886
+ P + P+ +A + T+
Sbjct: 4697 TNPSSTPGTTPITPVLTSTATTPAATS 4723
Score = 35.4 bits (80), Expect = 0.84
Identities = 54/259 (20%), Positives = 96/259 (37%), Gaps = 37/259 (14%)
Query: 1631 IPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEEQVASILNGAE 1690
IP S G ++ + + + TPT SS P T
Sbjct: 4528 IPSSSLGTTWTR---------LSQTTTPTATMSTATPSSTPET----------------- 4561
Query: 1691 LETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLK-PATSISSISQTKGINVKEILKS 1749
+ TST ++ +T + + S T + T K P T+ + + T + L
Sbjct: 4562 VHTST---VLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTAL-- 4616
Query: 1750 LVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVG 1809
PV I+ P + T + +P H+ R + GS+A +
Sbjct: 4617 --TPPVWISTTTTPTTTTPTTSGSTVTPSSIPGTTHTA-RVLTTTTTTVATGSMATPSSS 4673
Query: 1810 ATTAGSGLPTGSTSNIFAATGAT--PKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPA 1867
T+G+ +T+ ATG+T P S TT +S++++ ++ + ATS + P
Sbjct: 4674 TQTSGTPPSLTTTATTITATGSTTNPSSTPGTTPITPVLTSTATTPAATSSKATSSSSPR 4733
Query: 1868 VQTVAPMPEDSAENMSITA 1886
T P+ +A + T+
Sbjct: 4734 TATTLPVLTSTATKSTATS 4752
Score = 35.0 bits (79), Expect = 1.1
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSN-IFAATGATPKSMINTTGAVDSGSSSSSSSSSFVN 1858
PG+ + T TTA + TGST+ A P ++ TT + +SS ++ SS
Sbjct: 1904 PGTTWILTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTSSKATPSSSPG 1963
Query: 1859 GATSKNLPAVQTVAPMP 1875
AT+ LPA+++ A P
Sbjct: 1964 TATA--LPALRSTATTP 1978
Score = 33.5 bits (75), Expect = 3.2
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNG 1859
PG+ + T TTA + TGST+ + G P + T+ A ++SS ++SS +
Sbjct: 4247 PGTTWILTELTTTATTTASTGSTATPSSTPGTAPPPKVLTSPATTPTATSSKATSS-SSP 4305
Query: 1860 ATSKNLPAVQTVA 1872
T+ LP + + A
Sbjct: 4306 RTATTLPVLTSTA 4318
Score = 32.3 bits (72), Expect = 7.1
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 3/74 (4%)
Query: 1800 PGSLAVTTVGATTAGSGLPTGSTSNIFAATG-ATPKSMINTTGAVDSGSSSSSSSSSFVN 1858
PG+ + T T A + TGST+ + G A P ++ +T + +SS ++SSS
Sbjct: 2990 PGTTWILTEQTTAATTTATTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSSSSPR 3049
Query: 1859 GATSKNLPAVQTVA 1872
AT+ LP + + A
Sbjct: 3050 TATT--LPVLTSTA 3061
Score = 32.3 bits (72), Expect = 7.1
Identities = 62/296 (20%), Positives = 109/296 (36%), Gaps = 37/296 (12%)
Query: 1604 INSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFGHSFYKETPAAFPDT-------IKEKE 1656
+ + T+T S+ PS G A + + + TP++ P T I
Sbjct: 3283 LTTTTTTTRATGSVATPSSTPG-TAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTT 3341
Query: 1657 TPTPGEDIQVESSIPHTDSGIGEEQVASILNGAELETSTGPDAMSELLSTLSSEVKKSQE 1716
TPT SSIP G A++L +TG S + S++ +
Sbjct: 3342 TPTTRGSTVTPSSIP------GTTHTATVLTTTTTTVATG----SMATPSSSTQTSGTPP 3391
Query: 1717 SLTENPSETLKPATSISSISQTKGIN-VKEILKSLVAAPVEIAEC--------GPEPIPY 1767
SLT + T+ S ++ S T G + +L + P + P
Sbjct: 3392 SLTTTAT-TITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPV 3450
Query: 1768 PDPALKRETQAILPMQFH-------SFDRSVVVPVKKPPPGSLAVTTVGATTAGS--GLP 1818
P+ +++ P H S ++ P ++ T ATT+ + P
Sbjct: 3451 PNTTATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTPAATTSTTQHSTP 3510
Query: 1819 TGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPM 1874
S+ + + T +P S TT G+S ++++++ TS LP+ T AP+
Sbjct: 3511 ALSSPHPSSRTTESPPSPGTTTPGHTRGTSRTTATATPSKTRTSTLLPSSPTSAPI 3566
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 46.6 bits (109), Expect = 4e-04
Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 2692 ILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW 2751
I+I G D++ +V++ ETG+ ++GH V C+ E +VSGSRDATL +W
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------RVVSGSRDATLRVW 368
Score = 33.5 bits (75), Expect = 3.2
Identities = 54/248 (21%), Positives = 98/248 (39%), Gaps = 40/248 (16%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWY 2752
++ G D + +V+S TGK + + GH V S D I+SGS D TL +W
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW------SSQMRDNIIISGSTDRTLKVW- 328
Query: 2753 WSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTI-TG 2811
+++ L GH V C+ + + V+SG+++ V I TG
Sbjct: 329 -------------NAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETG 373
Query: 2812 DLLRALEG---PENCL---FPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDST 2865
L L G C+ R++S + + ++ ++ G +
Sbjct: 374 QCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG---------HTN 424
Query: 2866 RAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMAS 2925
R L DG ++V+G + + VW ++ G + M+L L++G A
Sbjct: 425 RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNAD 482
Query: 2926 GSIVAFNI 2933
++ ++I
Sbjct: 483 STVKIWDI 490
Score = 33.1 bits (74), Expect = 4.2
Identities = 42/172 (24%), Positives = 75/172 (43%), Gaps = 16/172 (9%)
Query: 2756 RHHIIGDNPNSSDYPAPRAVLTGHD-HEVVCVSVCAELGLVISGAKEGPCLV-HTITGDL 2813
R H I N + +P+ VL GHD H + C+ C ++SG+ + V +TG
Sbjct: 239 RQHRIDTNWRRGELKSPK-VLKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTGKC 295
Query: 2814 LRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNF--SINGKLLAQMEINDST-RAILL 2870
LR L G ++ S + II R + G+ + + + ST R + L
Sbjct: 296 LRTLVGHTGGVW----SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351
Query: 2871 SSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITG 2922
+ +V+G + + VW + L++ G A +R + +D R +++G
Sbjct: 352 HE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSG 399
Score = 33.1 bits (74), Expect = 4.2
Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 9/63 (14%)
Query: 2692 ILICGFWDKSFRVYSTETGKLTQIVFG---HWDVVTCLARSESYIGGDCYIVSGSRDATL 2748
IL+ G D + +++ +TG+ Q + G H VTCL +++ ++++ S D T+
Sbjct: 475 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN------FVITSSDDGTV 528
Query: 2749 LLW 2751
LW
Sbjct: 529 KLW 531
Score = 32.3 bits (72), Expect = 7.1
Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 31/153 (20%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW- 2751
++ G D + RV+ ETG+ ++ GH V C+ Y G +VSG+ D + +W
Sbjct: 356 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV----QYDGR--RVVSGAYDFMVKVWD 409
Query: 2752 --------------------YWSGRHHIIGDNPNSS---DYPAPRAVLTGHDHEVVCVSV 2788
+ G H + G S D + T H+ + +
Sbjct: 410 PETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 469
Query: 2789 CAELGLVISGAKEGPCLVHTI-TGDLLRALEGP 2820
+ +++SG + + I TG L+ L+GP
Sbjct: 470 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGP 502
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 46.6 bits (109), Expect = 4e-04
Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 2692 ILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW 2751
I+I G D++ +V++ ETG+ ++GH V C+ E +VSGSRDATL +W
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------RVVSGSRDATLRVW 486
Score = 33.5 bits (75), Expect = 3.2
Identities = 54/248 (21%), Positives = 98/248 (39%), Gaps = 40/248 (16%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWY 2752
++ G D + +V+S TGK + + GH V S D I+SGS D TL +W
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW------SSQMRDNIIISGSTDRTLKVW- 446
Query: 2753 WSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTI-TG 2811
+++ L GH V C+ + + V+SG+++ V I TG
Sbjct: 447 -------------NAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETG 491
Query: 2812 DLLRALEG---PENCL---FPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDST 2865
L L G C+ R++S + + ++ ++ G +
Sbjct: 492 QCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG---------HTN 542
Query: 2866 RAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMAS 2925
R L DG ++V+G + + VW ++ G + M+L L++G A
Sbjct: 543 RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNAD 600
Query: 2926 GSIVAFNI 2933
++ ++I
Sbjct: 601 STVKIWDI 608
Score = 33.1 bits (74), Expect = 4.2
Identities = 42/172 (24%), Positives = 75/172 (43%), Gaps = 16/172 (9%)
Query: 2756 RHHIIGDNPNSSDYPAPRAVLTGHD-HEVVCVSVCAELGLVISGAKEGPCLV-HTITGDL 2813
R H I N + +P+ VL GHD H + C+ C ++SG+ + V +TG
Sbjct: 357 RQHRIDTNWRRGELKSPK-VLKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTGKC 413
Query: 2814 LRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNF--SINGKLLAQMEINDST-RAILL 2870
LR L G ++ S + II R + G+ + + + ST R + L
Sbjct: 414 LRTLVGHTGGVW----SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469
Query: 2871 SSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITG 2922
+ +V+G + + VW + L++ G A +R + +D R +++G
Sbjct: 470 HE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSG 517
Score = 33.1 bits (74), Expect = 4.2
Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 9/63 (14%)
Query: 2692 ILICGFWDKSFRVYSTETGKLTQIVFG---HWDVVTCLARSESYIGGDCYIVSGSRDATL 2748
IL+ G D + +++ +TG+ Q + G H VTCL +++ ++++ S D T+
Sbjct: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN------FVITSSDDGTV 646
Query: 2749 LLW 2751
LW
Sbjct: 647 KLW 649
Score = 32.3 bits (72), Expect = 7.1
Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 31/153 (20%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW- 2751
++ G D + RV+ ETG+ ++ GH V C+ Y G +VSG+ D + +W
Sbjct: 474 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV----QYDGR--RVVSGAYDFMVKVWD 527
Query: 2752 --------------------YWSGRHHIIGDNPNSS---DYPAPRAVLTGHDHEVVCVSV 2788
+ G H + G S D + T H+ + +
Sbjct: 528 PETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 587
Query: 2789 CAELGLVISGAKEGPCLVHTI-TGDLLRALEGP 2820
+ +++SG + + I TG L+ L+GP
Sbjct: 588 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGP 620
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 46.6 bits (109), Expect = 4e-04
Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 2692 ILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW 2751
I+I G D++ +V++ ETG+ ++GH V C+ E +VSGSRDATL +W
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------RVVSGSRDATLRVW 406
Score = 33.5 bits (75), Expect = 3.2
Identities = 54/248 (21%), Positives = 98/248 (39%), Gaps = 40/248 (16%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWY 2752
++ G D + +V+S TGK + + GH V S D I+SGS D TL +W
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW------SSQMRDNIIISGSTDRTLKVW- 366
Query: 2753 WSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTI-TG 2811
+++ L GH V C+ + + V+SG+++ V I TG
Sbjct: 367 -------------NAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETG 411
Query: 2812 DLLRALEG---PENCL---FPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDST 2865
L L G C+ R++S + + ++ ++ G +
Sbjct: 412 QCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG---------HTN 462
Query: 2866 RAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMAS 2925
R L DG ++V+G + + VW ++ G + M+L L++G A
Sbjct: 463 RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNAD 520
Query: 2926 GSIVAFNI 2933
++ ++I
Sbjct: 521 STVKIWDI 528
Score = 33.1 bits (74), Expect = 4.2
Identities = 42/172 (24%), Positives = 75/172 (43%), Gaps = 16/172 (9%)
Query: 2756 RHHIIGDNPNSSDYPAPRAVLTGHD-HEVVCVSVCAELGLVISGAKEGPCLV-HTITGDL 2813
R H I N + +P+ VL GHD H + C+ C ++SG+ + V +TG
Sbjct: 277 RQHRIDTNWRRGELKSPK-VLKGHDDHVITCLQFCG--NRIVSGSDDNTLKVWSAVTGKC 333
Query: 2814 LRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNF--SINGKLLAQMEINDST-RAILL 2870
LR L G ++ S + II R + G+ + + + ST R + L
Sbjct: 334 LRTLVGHTGGVW----SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389
Query: 2871 SSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITG 2922
+ +V+G + + VW + L++ G A +R + +D R +++G
Sbjct: 390 HE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSG 437
Score = 33.1 bits (74), Expect = 4.2
Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 9/63 (14%)
Query: 2692 ILICGFWDKSFRVYSTETGKLTQIVFG---HWDVVTCLARSESYIGGDCYIVSGSRDATL 2748
IL+ G D + +++ +TG+ Q + G H VTCL +++ ++++ S D T+
Sbjct: 513 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN------FVITSSDDGTV 566
Query: 2749 LLW 2751
LW
Sbjct: 567 KLW 569
Score = 32.3 bits (72), Expect = 7.1
Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 31/153 (20%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW- 2751
++ G D + RV+ ETG+ ++ GH V C+ Y G +VSG+ D + +W
Sbjct: 394 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV----QYDGR--RVVSGAYDFMVKVWD 447
Query: 2752 --------------------YWSGRHHIIGDNPNSS---DYPAPRAVLTGHDHEVVCVSV 2788
+ G H + G S D + T H+ + +
Sbjct: 448 PETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGM 507
Query: 2789 CAELGLVISGAKEGPCLVHTI-TGDLLRALEGP 2820
+ +++SG + + I TG L+ L+GP
Sbjct: 508 ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGP 540
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 46.2 bits (108), Expect = 5e-04
Identities = 58/265 (21%), Positives = 102/265 (38%), Gaps = 50/265 (18%)
Query: 2696 GFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW---- 2751
G +DK+ +++S ETGK GH + CL S+ + +GS D T LW
Sbjct: 153 GSFDKTCKLWSVETGKCYHTFRGHTAEIVCL----SFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 2752 ---YWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVV------------CVSVCAEL---- 2792
++ R H S + R + DH VV + CAE+
Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268
Query: 2793 -----GLVISGAKEGPC---------LVHTITGDLLRALEGPENCLFPRLISVSSEGHCI 2838
L+++G+ + C V T+TG L+ + + + S++G
Sbjct: 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328
Query: 2839 IYYERGRFSNFSINGKLLAQMEIND-STRAILLSSDGQNLVTGGDNGVVEVWQACDFKQL 2897
I+ R K +A++E ++ I + G +L+TG + +W A + L
Sbjct: 329 IFSAATR--------KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 2898 YIYPGCDAGIRAMDLSHDQRTLITG 2922
+ G I + ++ +ITG
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITG 405
Score = 44.3 bits (103), Expect = 0.002
Identities = 53/232 (22%), Positives = 95/232 (40%), Gaps = 29/232 (12%)
Query: 2664 NKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVV 2723
N ++ L S +I + F + D +I G +D + V+ +TG+ I+ GH
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDR---IITGSFDHTVVVWDADTGRKVNILIGH---- 260
Query: 2724 TCLARSESYIGGDC-YIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHE 2782
C S + DC I++GS D T LW D N A LTGHD E
Sbjct: 261 -CAEISSASFNWDCSLILTGSMDKTCKLW----------DATNGKCV----ATLTGHDDE 305
Query: 2783 VVCVSVCAELGLVISGAKEGPCLVHT-ITGDLLRALEGPENCLFPRLISVSSEGHCIIYY 2841
++ L+ + + +G + + T + LEG E + IS + +G+ ++
Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEI--SKISFNPQGNHLLTG 363
Query: 2842 ERGRFSNF--SINGKLLAQME-INDSTRAILLSSDGQNLVTGGDNGVVEVWQ 2890
+ + + G+ L +E D + + G ++TG + +W+
Sbjct: 364 SSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 46.2 bits (108), Expect = 5e-04
Identities = 62/262 (23%), Positives = 113/262 (43%), Gaps = 48/262 (18%)
Query: 2680 AHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYI 2739
A+C D R +L+ G D +++ + GH V + + ++
Sbjct: 83 AYCATFRQDGR-LLVAGSEDGGVQLFDISGRAPLRQFEGHTKAV----HTVDFTADKYHV 137
Query: 2740 VSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAEL---GLVI 2796
VSG+ D T+ LW D PNS + +LT +H CA L I
Sbjct: 138 VSGADDYTVKLW----------DIPNSKE------ILTFKEHSDYVRCGCASKLNPDLFI 181
Query: 2797 SGAKEGPCLVHTI------TGDLLRALEGPENC----LFPRL-ISVSSEGHCIIYYERGR 2845
+G+ + HT+ T + + ++E + LFP + VS+ G + ++ +
Sbjct: 182 TGSYD-----HTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLK 236
Query: 2846 FSNFSINGKLLAQMEINDSTRAIL-LSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCD 2904
G+LL ++ + T L LSS GQ L++G + V+V+ +K ++ +
Sbjct: 237 ------GGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYA- 289
Query: 2905 AGIRAMDLSHDQRTLITGMASG 2926
A I ++ L+H+ T++ GM +G
Sbjct: 290 ASILSLALAHEDETIVVGMTNG 311
>gi|124028510 WD40-repeat protein upregulated in HCC isoform c [Homo
sapiens]
Length = 552
Score = 45.8 bits (107), Expect = 6e-04
Identities = 53/258 (20%), Positives = 110/258 (42%), Gaps = 36/258 (13%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFG-HWDVVTCLARSESYIGGDCY-IVSGSRDATLLL 2750
+I + D R ++ ETG+L ++ H VT +A + DC ++SG + + +
Sbjct: 321 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTS-----DCKRVISGGGEGEVRV 375
Query: 2751 WYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTIT 2810
W IG + L H V C+ V ++ + +G C++
Sbjct: 376 WQ-------IGCQTQKLE-----EALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW--- 420
Query: 2811 GDLLRALEGP---ENCLFPRLISVSSEGHCIIYYERGRFSNFSI-NGKLLAQME--INDS 2864
DL+R N LF + E I + + + + +G ++ ++E ++ S
Sbjct: 421 -DLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS 479
Query: 2865 TRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMA 2924
+ ++ +G + VTGG++ +V+VW + + ++ G I + +S + +++ A
Sbjct: 480 INGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSA 539
Query: 2925 SGSIVAFNIDFNRWHYEH 2942
G+I+ RW Y +
Sbjct: 540 DGAIL-------RWKYPY 550
>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
sapiens]
Length = 620
Score = 45.8 bits (107), Expect = 6e-04
Identities = 53/258 (20%), Positives = 110/258 (42%), Gaps = 36/258 (13%)
Query: 2693 LICGFWDKSFRVYSTETGKLTQIVFG-HWDVVTCLARSESYIGGDCY-IVSGSRDATLLL 2750
+I + D R ++ ETG+L ++ H VT +A + DC ++SG + + +
Sbjct: 389 IISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTS-----DCKRVISGGGEGEVRV 443
Query: 2751 WYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTIT 2810
W IG + L H V C+ V ++ + +G C++
Sbjct: 444 WQ-------IGCQTQKLE-----EALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW--- 488
Query: 2811 GDLLRALEGP---ENCLFPRLISVSSEGHCIIYYERGRFSNFSI-NGKLLAQME--INDS 2864
DL+R N LF + E I + + + + +G ++ ++E ++ S
Sbjct: 489 -DLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGS 547
Query: 2865 TRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMA 2924
+ ++ +G + VTGG++ +V+VW + + ++ G I + +S + +++ A
Sbjct: 548 INGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSA 607
Query: 2925 SGSIVAFNIDFNRWHYEH 2942
G+I+ RW Y +
Sbjct: 608 DGAIL-------RWKYPY 618
>gi|27436925 synoviolin 1 isoform a [Homo sapiens]
Length = 616
Score = 45.1 bits (105), Expect = 0.001
Identities = 44/150 (29%), Positives = 59/150 (39%), Gaps = 12/150 (8%)
Query: 1754 PVEIAECGPEPIPYPDPALKRET---QAILPM----QFHSFDRSVVVPVKKPPPGSLAVT 1806
P E A+ GP P P+P P L + Q +LP F + P PPP S
Sbjct: 345 PPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEAV 404
Query: 1807 TVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSS---SFVNGATSK 1863
+T+A P+G+ + A T AT S T SGS+ + + F
Sbjct: 405 APPSTSAALSRPSGAATTTAAGTSATAASA--TASGPGSGSAPEAGPAPGFPFPPPWMGM 462
Query: 1864 NLPAVQTVAPMPEDSAENMSITAKLERALE 1893
LP PMP A +T + RALE
Sbjct: 463 PLPPPFAFPPMPVPPAGFAGLTPEELRALE 492
>gi|89145413 short stature homeobox 2 isoform a [Homo sapiens]
Length = 331
Score = 45.1 bits (105), Expect = 0.001
Identities = 21/33 (63%), Positives = 23/33 (69%)
Query: 21 AVGAAGGGGGGSGGGGTGGSGMGELRGASGSGS 53
AV AAGGGGGG GGGG GG G G G +G G+
Sbjct: 55 AVRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGA 87
Score = 42.7 bits (99), Expect = 0.005
Identities = 20/37 (54%), Positives = 21/37 (56%)
Query: 16 PVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSG 52
P A G GGGGGG GGGG GG G G G +G G
Sbjct: 54 PAVRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGAGGG 90
Score = 39.7 bits (91), Expect = 0.045
Identities = 17/38 (44%), Positives = 20/38 (52%)
Query: 20 IAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLP 57
+ GGGGGG GGGG GG G+G G+G P
Sbjct: 56 VRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGAGGGRSP 93
>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
Length = 2382
Score = 44.7 bits (104), Expect = 0.001
Identities = 70/335 (20%), Positives = 125/335 (37%), Gaps = 51/335 (15%)
Query: 1596 PGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEK 1655
P ++ Q+I PTS++ + S F+ +PE S K P+ DT+
Sbjct: 1232 PASSMPQQIGIPTSSLTQVVH----SAGRRFIVSPVPESRLRES--KVFPSEITDTVAAS 1285
Query: 1656 ETPTPGEDIQVESSIPHTDSGIGEEQVASILNGAELE----TSTGPD--AMSELLSTLSS 1709
+PG ++ +S E + A + G + TGP + LS+++
Sbjct: 1286 TAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAG 1345
Query: 1710 EVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLVAAPVEIAECGPEPIPYPD 1769
V + + P+ + P +S+ Q++ E + VA + G PIP
Sbjct: 1346 -VPTTAAATAPVPATSSPPNDISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIP--- 1401
Query: 1770 PALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGLPTGSTSNIFAAT 1829
P+ SVV + P AV ++ T+ +PT ++ + ++T
Sbjct: 1402 -----------PVSESPVLSSVVSSITIP-----AVVSISTTSPSLQVPTSTSEIVVSST 1445
Query: 1830 GATPKSMINTTGAVDSGSS-----------SSSSSSSFVNGATSKNLPAVQTVAPMPEDS 1878
P ++ T A GS+ S ++ S GAT L +V T P +
Sbjct: 1446 ALYPSVTVSATSASAGGSTATPGPKPPAVVSQQAAGSTTVGAT---LTSVSTTTSFPSTA 1502
Query: 1879 AENMSITAKLERALEKVAPLLREIFVDFAPFLSRT 1913
++ ++ + P L E V A L +T
Sbjct: 1503 SQ-----LSIQLSSSTSTPTLAETVVVSAHSLDKT 1532
Score = 35.0 bits (79), Expect = 1.1
Identities = 69/298 (23%), Positives = 114/298 (38%), Gaps = 35/298 (11%)
Query: 1645 PAAFPDTIKEKETPTPGEDI-----QVESSIPHTDSGIGEEQVASILNGAELETSTG--- 1696
P T T +P DI Q E ++P EE +A + + TS G
Sbjct: 1347 PTTAAATAPVPATSSPPNDISTSVIQSEVTVPT------EEGIAGVATSTGVVTSGGLPI 1400
Query: 1697 -PDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLVAAPV 1755
P + S +LS++ S + S +L+ TS S I ++ + S+ +
Sbjct: 1401 PPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIV----VSSTALYPSVTVSAT 1456
Query: 1756 EIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGS 1815
+ G P P P QA + SV P S + ++T+
Sbjct: 1457 SASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLSIQLSSSTS-- 1514
Query: 1816 GLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSS------SSFVN---GATSKNLP 1866
PT + + + +A S +TTG S S+ SSSS SS+++ G +P
Sbjct: 1515 -TPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSSPGAGVSSYISQPGGLHPLVIP 1573
Query: 1867 AVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLI 1924
+V P+ +A S L + + PL++ V P + +TL+ S Q L+
Sbjct: 1574 SVIASTPILPQAAGPTS--TPLLPQVPSIPPLVQP--VANVPAVQQTLIHSQPQPALL 1627
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 44.7 bits (104), Expect = 0.001
Identities = 40/119 (33%), Positives = 50/119 (42%), Gaps = 21/119 (17%)
Query: 7 GPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGS--GSVMLPAGMINPS 64
G G GL GLI+ GGGGGG GGGG GG G G G ++ A NP
Sbjct: 20 GLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPE 79
Query: 65 VP----------------IRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLE 107
P +R R FA L G EVS +++ +LN +V DL+
Sbjct: 80 PPPPRTHYSNIEANESEEVRQFRRLFAQLAG--DDMEVSATELM-NILNKVVTRHPDLK 135
Score = 36.6 bits (83), Expect = 0.38
Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Query: 7 GPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLPAGMIN 62
G G G +G + G G GGG GGGG GG G G G G ++ + G+I+
Sbjct: 15 GGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGG---GGGGGTAMRILGGVIS 67
Score = 34.7 bits (78), Expect = 1.4
Identities = 15/27 (55%), Positives = 18/27 (66%)
Query: 27 GGGGGSGGGGTGGSGMGELRGASGSGS 53
GGGGG GGGG G G+G + G SG+
Sbjct: 10 GGGGGGGGGGGLGGGLGNVLGGLISGA 36
Score = 34.7 bits (78), Expect = 1.4
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 23 GAAGGGGGGSGGGGTGGSGMGELRGASGSG 52
G GGGGGG GGG G G + GA G G
Sbjct: 11 GGGGGGGGGGLGGGLGNVLGGLISGAGGGG 40
Score = 32.3 bits (72), Expect = 7.1
Identities = 18/46 (39%), Positives = 20/46 (43%), Gaps = 13/46 (28%)
Query: 23 GAAGGGG-------------GGSGGGGTGGSGMGELRGASGSGSVM 55
G GGGG G+GGGG GG G G G G G+ M
Sbjct: 14 GGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAM 59
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 110,580,894
Number of Sequences: 37866
Number of extensions: 5142450
Number of successful extensions: 33218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 250
Number of HSP's successfully gapped in prelim test: 259
Number of HSP's that attempted gapping in prelim test: 24301
Number of HSP's gapped (non-prelim): 5254
length of query: 2946
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2826
effective length of database: 13,703,598
effective search space: 38726367948
effective search space used: 38726367948
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.