Search of human proteins with 62241003

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62241003 cardiomyopathy associated 5 [Homo sapiens]
         (4069 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62241003 cardiomyopathy associated 5 [Homo sapiens]               7965   0.0  
gi|55741632 fibronectin type III and SPRY domain containing 2 [H...   333   2e-90
gi|89886468 fibronectin type III and SPRY domain containing 1-li...    99   7e-20
gi|223718222 fibronectin type III and SPRY domain containing 1-l...    99   9e-20
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        94   4e-18
gi|91982772 mucin 17 [Homo sapiens]                                    91   2e-17
gi|148833499 midline 1 [Homo sapiens]                                  90   5e-17
gi|4557753 midline 1 [Homo sapiens]                                    90   5e-17
gi|15451852 midline 1 [Homo sapiens]                                   90   5e-17
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         89   1e-16
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          85   1e-15
gi|110349719 titin isoform N2-A [Homo sapiens]                         83   5e-15
gi|223890259 midline 2 isoform 2 [Homo sapiens]                        82   1e-14
gi|223890257 midline 2 isoform 1 [Homo sapiens]                        82   1e-14
gi|34878844 tripartite motif-containing 55 isoform 3 [Homo sapiens]    80   4e-14
gi|34878836 tripartite motif-containing 55 isoform 1 [Homo sapiens]    80   4e-14
gi|34878821 tripartite motif-containing 55 isoform 2 [Homo sapiens]    80   4e-14
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    79   7e-14
gi|62865606 tripartite motif-containing 36 isoform 1 [Homo sapiens]    78   2e-13
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     77   3e-13
gi|150170670 piccolo isoform 2 [Homo sapiens]                          77   3e-13
gi|150378539 piccolo isoform 1 [Homo sapiens]                          77   3e-13
gi|46409324 SPRY domain containing 4 [Homo sapiens]                    77   5e-13
gi|78482626 ring finger protein 30 isoform 2 [Homo sapiens]            75   2e-12
gi|19924163 muscle specific ring finger protein 1 [Homo sapiens]       72   9e-12
gi|190341104 tripartite motif protein 9 isoform 1 [Homo sapiens]       72   1e-11
gi|63054855 erythroblast membrane-associated protein precursor [...    72   1e-11
gi|19923536 erythroblast membrane-associated protein precursor [...    72   1e-11
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    71   2e-11
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         71   2e-11

>gi|62241003 cardiomyopathy associated 5 [Homo sapiens]
          Length = 4069

 Score = 7965 bits (20666), Expect = 0.0
 Identities = 4069/4069 (100%), Positives = 4069/4069 (100%)

Query: 1    MASRDSNHAGESFLGSDGDEEATRELETEEESEGEEDETAAESEEEPDSRLSDQDEEGKI 60
            MASRDSNHAGESFLGSDGDEEATRELETEEESEGEEDETAAESEEEPDSRLSDQDEEGKI
Sbjct: 1    MASRDSNHAGESFLGSDGDEEATRELETEEESEGEEDETAAESEEEPDSRLSDQDEEGKI 60

Query: 61   KQEYIISDPSFSMVTVQREDSGITWETNSSRSSTPWASEESQTSGVCSREGSTVNSPPGN 120
            KQEYIISDPSFSMVTVQREDSGITWETNSSRSSTPWASEESQTSGVCSREGSTVNSPPGN
Sbjct: 61   KQEYIISDPSFSMVTVQREDSGITWETNSSRSSTPWASEESQTSGVCSREGSTVNSPPGN 120

Query: 121  VSFIVDEVKKVRKRTHKSKHGSPSLRRKGNRKRNSFESQDVPTNKKGSPLTSASQVLTTE 180
            VSFIVDEVKKVRKRTHKSKHGSPSLRRKGNRKRNSFESQDVPTNKKGSPLTSASQVLTTE
Sbjct: 121  VSFIVDEVKKVRKRTHKSKHGSPSLRRKGNRKRNSFESQDVPTNKKGSPLTSASQVLTTE 180

Query: 181  KEKSYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELI 240
            KEKSYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELI
Sbjct: 181  KEKSYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELI 240

Query: 241  PLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVF 300
            PLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVF
Sbjct: 241  PLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVF 300

Query: 301  PPWRGALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHS 360
            PPWRGALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHS
Sbjct: 301  PPWRGALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHS 360

Query: 361  QSVPQQPEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFAN 420
            QSVPQQPEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFAN
Sbjct: 361  QSVPQQPEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFAN 420

Query: 421  EVKKEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSV 480
            EVKKEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSV
Sbjct: 421  EVKKEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSV 480

Query: 481  KGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESP 540
            KGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESP
Sbjct: 481  KGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESP 540

Query: 541  LVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSV 600
            LVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSV
Sbjct: 541  LVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSV 600

Query: 601  PQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEK 660
            PQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEK
Sbjct: 601  PQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEK 660

Query: 661  TSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSP 720
            TSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSP
Sbjct: 661  TSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSP 720

Query: 721  LILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVP 780
            LILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVP
Sbjct: 721  LILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVP 780

Query: 781  SEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKEV 840
            SEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKEV
Sbjct: 781  SEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKEV 840

Query: 841  IGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSA 900
            IGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSA
Sbjct: 841  IGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSA 900

Query: 901  SEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPY 960
            SEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPY
Sbjct: 901  SEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPY 960

Query: 961  ATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNE 1020
            ATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNE
Sbjct: 961  ATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNE 1020

Query: 1021 LEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSL 1080
            LEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSL
Sbjct: 1021 LEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSL 1080

Query: 1081 PPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGER 1140
            PPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGER
Sbjct: 1081 PPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGER 1140

Query: 1141 EASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMA 1200
            EASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMA
Sbjct: 1141 EASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMA 1200

Query: 1201 LSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVL 1260
            LSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVL
Sbjct: 1201 LSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVL 1260

Query: 1261 NVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSAS 1320
            NVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSAS
Sbjct: 1261 NVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSAS 1320

Query: 1321 SGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLI 1380
            SGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLI
Sbjct: 1321 SGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLI 1380

Query: 1381 TPVDRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAE 1440
            TPVDRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAE
Sbjct: 1381 TPVDRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAE 1440

Query: 1441 KEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFS 1500
            KEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFS
Sbjct: 1441 KEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFS 1500

Query: 1501 TVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPK 1560
            TVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPK
Sbjct: 1501 TVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPK 1560

Query: 1561 GKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSL 1620
            GKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSL
Sbjct: 1561 GKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSL 1620

Query: 1621 EPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSRE 1680
            EPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSRE
Sbjct: 1621 EPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSRE 1680

Query: 1681 GKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEE 1740
            GKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEE
Sbjct: 1681 GKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEE 1740

Query: 1741 FQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNSS 1800
            FQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNSS
Sbjct: 1741 FQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNSS 1800

Query: 1801 QVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMREN 1860
            QVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMREN
Sbjct: 1801 QVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMREN 1860

Query: 1861 LPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSS 1920
            LPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSS
Sbjct: 1861 LPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSS 1920

Query: 1921 SNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSY 1980
            SNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSY
Sbjct: 1921 SNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSY 1980

Query: 1981 SSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKI 2040
            SSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKI
Sbjct: 1981 SSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKI 2040

Query: 2041 KLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEK 2100
            KLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEK
Sbjct: 2041 KLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEK 2100

Query: 2101 PLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPK 2160
            PLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPK
Sbjct: 2101 PLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPK 2160

Query: 2161 VAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPE 2220
            VAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPE
Sbjct: 2161 VAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPE 2220

Query: 2221 GTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKF 2280
            GTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKF
Sbjct: 2221 GTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKF 2280

Query: 2281 ISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHV 2340
            ISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHV
Sbjct: 2281 ISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHV 2340

Query: 2341 TDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNI 2400
            TDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNI
Sbjct: 2341 TDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNI 2400

Query: 2401 TKESEKPESIILPVEESKGSLIDFSEDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNL 2460
            TKESEKPESIILPVEESKGSLIDFSEDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNL
Sbjct: 2401 TKESEKPESIILPVEESKGSLIDFSEDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNL 2460

Query: 2461 ENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQN 2520
            ENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQN
Sbjct: 2461 ENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQN 2520

Query: 2521 EDYNERPKIIVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSL 2580
            EDYNERPKIIVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSL
Sbjct: 2521 EDYNERPKIIVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSL 2580

Query: 2581 GETQSFSLVKATSVTEKSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVAL 2640
            GETQSFSLVKATSVTEKSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVAL
Sbjct: 2581 GETQSFSLVKATSVTEKSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVAL 2640

Query: 2641 SCRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQE 2700
            SCRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQE
Sbjct: 2641 SCRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQE 2700

Query: 2701 KAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEE 2760
            KAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEE
Sbjct: 2701 KAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEE 2760

Query: 2761 KEQFKESELWKGGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTL 2820
            KEQFKESELWKGGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTL
Sbjct: 2761 KEQFKESELWKGGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTL 2820

Query: 2821 ASGASPEINAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTR 2880
            ASGASPEINAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTR
Sbjct: 2821 ASGASPEINAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTR 2880

Query: 2881 VKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQ 2940
            VKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQ
Sbjct: 2881 VKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQ 2940

Query: 2941 KTAFSIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVAC 3000
            KTAFSIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVAC
Sbjct: 2941 KTAFSIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVAC 3000

Query: 3001 HKTLKSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLID 3060
            HKTLKSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLID
Sbjct: 3001 HKTLKSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLID 3060

Query: 3061 YNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYGPEK 3120
            YNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYGPEK
Sbjct: 3061 YNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYGPEK 3120

Query: 3121 GHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTIKVIDP 3180
            GHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTIKVIDP
Sbjct: 3121 GHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTIKVIDP 3180

Query: 3181 EFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGTGIYFEK 3240
            EFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGTGIYFEK
Sbjct: 3181 EFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGTGIYFEK 3240

Query: 3241 YILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQKG 3300
            YILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQKG
Sbjct: 3241 YILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQKG 3300

Query: 3301 VYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHVLERADEAGSHGN 3360
            VYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHVLERADEAGSHGN
Sbjct: 3301 VYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHVLERADEAGSHGN 3360

Query: 3361 EVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDE 3420
            EVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDE
Sbjct: 3361 EVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDE 3420

Query: 3421 YEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKESFEHISENEFASEAEQSTPAEQKE 3480
            YEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKESFEHISENEFASEAEQSTPAEQKE
Sbjct: 3421 YEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKESFEHISENEFASEAEQSTPAEQKE 3480

Query: 3481 LGSERKEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDT 3540
            LGSERKEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDT
Sbjct: 3481 LGSERKEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDT 3540

Query: 3541 AISAVKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVL 3600
            AISAVKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVL
Sbjct: 3541 AISAVKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVL 3600

Query: 3601 AQYDEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEE 3660
            AQYDEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEE
Sbjct: 3601 AQYDEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEE 3660

Query: 3661 INERLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPNSATS 3720
            INERLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPNSATS
Sbjct: 3661 INERLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPNSATS 3720

Query: 3721 TTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQ 3780
            TTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQ
Sbjct: 3721 TTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQ 3780

Query: 3781 VWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEY 3840
            VWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEY
Sbjct: 3781 VWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEY 3840

Query: 3841 CRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRF 3900
            CRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRF
Sbjct: 3841 CRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRF 3900

Query: 3901 LLLRETAHPALHISSSGTVISFGERRRLTEIPSVLGEELPSCGQHYWETTVTDCPAYRLG 3960
            LLLRETAHPALHISSSGTVISFGERRRLTEIPSVLGEELPSCGQHYWETTVTDCPAYRLG
Sbjct: 3901 LLLRETAHPALHISSSGTVISFGERRRLTEIPSVLGEELPSCGQHYWETTVTDCPAYRLG 3960

Query: 3961 ICSSSAVQAGALGQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRL 4020
            ICSSSAVQAGALGQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRL
Sbjct: 3961 ICSSSAVQAGALGQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRL 4020

Query: 4021 IFINAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSVRHK 4069
            IFINAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSVRHK
Sbjct: 4021 IFINAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSVRHK 4069


>gi|55741632 fibronectin type III and SPRY domain containing 2 [Homo
            sapiens]
          Length = 749

 Score =  333 bits (854), Expect = 2e-90
 Identities = 195/584 (33%), Positives = 306/584 (52%), Gaps = 23/584 (3%)

Query: 3501 QKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKS 3560
            ++E ++   D +C TCK PI A  KVF  HK+HEV  L+ A+ + K ++ + +  L+++ 
Sbjct: 168  EEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQI 227

Query: 3561 LRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEF 3620
            + +E F + +E  F T+EEN  K E+  E    E+++ +  +Y+EK Q+  E KK+K+E 
Sbjct: 228  IEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEA 287

Query: 3621 LHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPA 3680
            L+ Q+V   +++DT K+ +ETI     E ++  F+     + +RL   +++   +E   +
Sbjct: 288  LYGQLVSCGENLDTCKELMETIEEMCHE-EKVDFIKDAVAMADRLGKFLKTKTDVE--IS 344

Query: 3681 AFSLFEHYDDSSARSDQM---LKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDS 3737
            A   FE      +  +Q+   +  +  P  P + PQ PNSAT +++ V WS+  +D ++S
Sbjct: 345  AQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVES 404

Query: 3738 FQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSER 3797
            +Q+     P  D        E+ +TVKE+YC   +L P+  Y+ WV A N  G S  SER
Sbjct: 405  YQL--SYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSER 462

Query: 3798 AIFRTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEYCRQHSPEGEGL-RSFSG 3856
            A++ TAPS P+I+ ++   C     I W        ++YT+E  +  SPE  G+  S  G
Sbjct: 463  AVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVG 522

Query: 3857 IKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPALHISSS 3916
            I   +  V LQP  +Y  YVRA+N  G S +SE A + T G+ F L ++T HP L IS  
Sbjct: 523  IPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISED 582

Query: 3917 GTVISFGERR-----------RLTEIPSVLGEELPSCGQHYWETTVTDCPAYRLGICSSS 3965
            G      ERR             T   +V+G  +P  G HYWE  V +   YR+G+  + 
Sbjct: 583  GLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFAD 642

Query: 3966 AVQAGALGQGETSWYMH---CSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRLIF 4022
              +   LG    SW M     S   +Y F ++    D+ +T  P ++GILLDY + +L F
Sbjct: 643  VRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSF 702

Query: 4023 INAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSV 4066
             N +  Q L+    + +E VHP F+LEKPG   +H GI  P  V
Sbjct: 703  FNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHV 746


>gi|89886468 fibronectin type III and SPRY domain containing 1-like
            isoform 1 [Homo sapiens]
          Length = 498

 Score = 99.4 bits (246), Expect = 7e-20
 Identities = 118/533 (22%), Positives = 217/533 (40%), Gaps = 72/533 (13%)

Query: 3546 KVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDE 3605
            K  L   +  L  K+  I+ F+  +      ++EN S     L+E+ + +   +    + 
Sbjct: 5    KEALQRIISTLANKNDEIQNFIDTLHHTLKGVQENSSNILSELDEEFDSLYSILDEVKES 64

Query: 3606 KAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERL 3665
                 ++ + +K + L  Q+     +++ +++ LE   R  +  +   F  +  +I +R+
Sbjct: 65   MINCIKQEQARKSQELQSQISQCNNALENSEELLEFATRSLDIKEPEEFSKAARQIKDRV 124

Query: 3666 LSAMESTASLEKMPAAFSLFEHYDDSSARSD-QMLKQVAVPQPPRLEPQEPNSATSTTIA 3724
              A     SL+   +        D S  R   Q LK + VP+ P ++P E   A   ++ 
Sbjct: 125  TMASAFRLSLKPKVSDNMTHLMVDFSQERQMLQTLKFLPVPKAPEIDPVECLVA-DNSVT 183

Query: 3725 VYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQVW-- 3782
            V W M                P++D +++  + E+R   K ++     ++ +RC+++   
Sbjct: 184  VAWRM----------------PEEDNKIDHFILEHR---KTNFDGLPRVKDERCWEIIDN 224

Query: 3783 VMAVNFT--GCSLPSERAIFRTAPSTPVIRAE-DCTVCWNTATIRWRPTTPEATETYTLE 3839
            +    +T  G    S+   FR       +  E    V   T  + +      +     +E
Sbjct: 225  IKGTEYTLSGLKFDSKYMNFRVRACNKAVAGEYSDPVTLETKALNFNLDNSSSHLNLKVE 284

Query: 3840 -YCRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGT 3898
              C +  P G G    S IKG + K                   GT      ++    G+
Sbjct: 285  DTCVEWDPTG-GKGQESKIKGKENK----------------GRSGTPSPKRTSV----GS 323

Query: 3899 RFLLLRETAHPALHISSSGTVISFGERRRLT-EIPSVLGEELPSCGQHYWETTV-TDCPA 3956
            R         PA+           G R R T E  +VLG+     GQHYWE     DC +
Sbjct: 324  R--------PPAVR----------GSRDRFTGESYTVLGDTAIESGQHYWEVKAQKDCKS 365

Query: 3957 YRLGICSSSAVQAGALGQGETSWYMHCSEPQRYTFF--YSGIVSDVHVTERPARVGILLD 4014
            Y +G+   +  +   LG+  TSW +H +   + TF   ++  V  + VT  P ++G+  D
Sbjct: 366  YSVGVAYKTLGKFDQLGKTNTSWCIHVNNWLQNTFAAKHNNKVKALDVTV-PEKIGVFCD 424

Query: 4015 YNNQRLIFINAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSVR 4067
            ++  +L F +A S+QLL+  + +F + V P F +   G  +L  G++ P +VR
Sbjct: 425  FDGGQLSFYDANSKQLLYSFKTKFTQPVLPGF-MVWCGGLSLSTGMQVPSAVR 476


>gi|223718222 fibronectin type III and SPRY domain containing 1-like
            isoform 3 [Homo sapiens]
          Length = 530

 Score = 99.0 bits (245), Expect = 9e-20
 Identities = 118/538 (21%), Positives = 220/538 (40%), Gaps = 72/538 (13%)

Query: 3541 AISAVKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVL 3600
            +I+  +  L   +  L  K+  I+ F+  +      ++EN S     L+E+ + +   + 
Sbjct: 32   SINLQQEALQRIISTLANKNDEIQNFIDTLHHTLKGVQENSSNILSELDEEFDSLYSILD 91

Query: 3601 AQYDEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEE 3660
               +      ++ + +K + L  Q+     +++ +++ LE   R  +  +   F  +  +
Sbjct: 92   EVKESMINCIKQEQARKSQELQSQISQCNNALENSEELLEFATRSLDIKEPEEFSKAARQ 151

Query: 3661 INERLLSAMESTASLEKMPAAFSLFEHYDDSSARSD-QMLKQVAVPQPPRLEPQEPNSAT 3719
            I +R+  A     SL+   +        D S  R   Q LK + VP+ P ++P E   A 
Sbjct: 152  IKDRVTMASAFRLSLKPKVSDNMTHLMVDFSQERQMLQTLKFLPVPKAPEIDPVECLVA- 210

Query: 3720 STTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCY 3779
              ++ V W M                P++D +++  + E+R   K ++     ++ +RC+
Sbjct: 211  DNSVTVAWRM----------------PEEDNKIDHFILEHR---KTNFDGLPRVKDERCW 251

Query: 3780 QVW--VMAVNFT--GCSLPSERAIFRTAPSTPVIRAE-DCTVCWNTATIRWRPTTPEATE 3834
            ++   +    +T  G    S+   FR       +  E    V   T  + +      +  
Sbjct: 252  EIIDNIKGTEYTLSGLKFDSKYMNFRVRACNKAVAGEYSDPVTLETKALNFNLDNSSSHL 311

Query: 3835 TYTLE-YCRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALI 3893
               +E  C +  P G G    S IKG + K                   GT      ++ 
Sbjct: 312  NLKVEDTCVEWDPTG-GKGQESKIKGKENK----------------GRSGTPSPKRTSV- 353

Query: 3894 STRGTRFLLLRETAHPALHISSSGTVISFGERRRLT-EIPSVLGEELPSCGQHYWETTV- 3951
               G+R         PA+           G R R T E  +VLG+     GQHYWE    
Sbjct: 354  ---GSR--------PPAVR----------GSRDRFTGESYTVLGDTAIESGQHYWEVKAQ 392

Query: 3952 TDCPAYRLGICSSSAVQAGALGQGETSWYMHCSEPQRYTFF--YSGIVSDVHVTERPARV 4009
             DC +Y +G+   +  +   LG+  TSW +H +   + TF   ++  V  + VT  P ++
Sbjct: 393  KDCKSYSVGVAYKTLGKFDQLGKTNTSWCIHVNNWLQNTFAAKHNNKVKALDVTV-PEKI 451

Query: 4010 GILLDYNNQRLIFINAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSVR 4067
            G+  D++  +L F +A S+QLL+  + +F + V P F +   G  +L  G++ P +VR
Sbjct: 452  GVFCDFDGGQLSFYDANSKQLLYSFKTKFTQPVLPGF-MVWCGGLSLSTGMQVPSAVR 508


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 93.6 bits (231), Expect = 4e-18
 Identities = 385/1934 (19%), Positives = 591/1934 (30%), Gaps = 271/1934 (14%)

Query: 306  ALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQSVPQ 365
            ALS G ES T   S              ++  +E +   +SS+G     +    S S   
Sbjct: 2154 ALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGL 2213

Query: 366  QPEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKE 425
            Q E  A          TP  P+T      +      SPG+  + +    S + +   +K 
Sbjct: 2214 QGESTAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTH-FPASSTTSGHSEKS 2272

Query: 426  DVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLT--PTHPSVKGE 483
             ++  H S      +P  A ST  G          ++  R  P S ++T  P   +  G 
Sbjct: 2273 TIF--HSSPDASGTTPSSAHSTTSGRGE-------STTSRISPGSTEITTLPGSTTTPGL 2323

Query: 484  KEENML------EPSISLSEPLMLEEPEKEEIET------SLPIAITPEPEDSNLVEEEI 531
             E +         P+ +LS   M      EE  T      S    ++P    +  + EE 
Sbjct: 2324 SEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEES 2383

Query: 532  VELDYPESPLVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTG 591
              + Y  SP  +E    P         EE        AS+  H  L  E+          
Sbjct: 2384 TTV-YSSSPGSTETTVFPRTPTTSVRGEEPTTFHSRPAST--HTTLFTEDSTTSGLTEES 2440

Query: 592  SAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTS-- 649
            +AF                Q G P   +  +   E               SPA + TS  
Sbjct: 2441 TAFPGS---------PASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGL 2491

Query: 650  -----ESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPS 704
                  S LSPS+TE T+   SP   +++ +         S     +P +T++S  S  S
Sbjct: 2492 VGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEES 2551

Query: 705  LATKESLKKTIDRKSP--LILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKT 762
              +      T     P      G+S +   S      GS    + PAS  +  PS    T
Sbjct: 2552 STSHSQPGSTHTTAFPDSTTTPGLSRHSTTSH--SSPGSTDTTLLPASTTTSGPSQESTT 2609

Query: 763  SECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQF 822
            S        TA S                 P S     +                E++ F
Sbjct: 2610 SHSSPGSTDTALS-----------------PGSTTALSFG--------------QESTTF 2638

Query: 823  KPKGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVL 882
                 S HT L  D     G       V S  +  P TT   +   +P L    + +   
Sbjct: 2639 HSSPGSTHTTLFPDSTTSSGIVEASTRVHSS-TGSPRTTLSPASSTSPGLQGESTTF--- 2694

Query: 883  SDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDI 942
                     +  P+ST  +  S P  AT   +E    HR                     
Sbjct: 2695 ---------QTHPASTHTTP-SPPSTATAPVEESTTYHR--------------------- 2723

Query: 943  GPFSPDSAFVSEFSFPPYATQEAEKREFECDSPIC--LTSPSEHTILSDEDTEEAELFSP 1000
               SP S   + F      +  +EK      SP     T  S H+  S          SP
Sbjct: 2724 ---SPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISP 2780

Query: 1001 DSASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSS 1060
             S    ++P    S T     E  +   +   S  +  S A    +G      V E+ ++
Sbjct: 2781 GSTEITTLPG---STTTPGLSEASTTFYSSPRSPTTTLSPASMTSLG------VGEESTT 2831

Query: 1061 SQKQKAETFPLMSPL---------EDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQ 1111
            S+ Q   T   +SP          E  ++  S+  S +  + P   TTS    E      
Sbjct: 2832 SRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTF-H 2890

Query: 1112 KQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHS 1171
             +    +    +ED   S LT E        +S+   +PA L       +  T P+S  S
Sbjct: 2891 SRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGS 2950

Query: 1172 VLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPP 1231
                  PA    +  T+ L  ++   +++          P S E T          P  P
Sbjct: 2951 TGTTLSPA----RSTTSGLVGESTPSRLS----------PSSTETTT--------LPGSP 2988

Query: 1232 NVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLS 1291
              P    K +        P   + P    + +   E+   S ++P      +    T+ S
Sbjct: 2989 TTPSLSEKSTTFYTSPRSPDATLSPATTTS-SGVSEESSTSHSQPGSTHTTAFPDSTTTS 3047

Query: 1292 GPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSAL--SEEIKKEIEP 1349
            G           +  ++ T +P    ++S G +    H  P    + L   + I   +  
Sbjct: 3048 GLSQEPTASHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVE 3107

Query: 1350 SSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPLVTSADE 1409
            +S+ T +S   L + LT A            T    P  +       G+   P+  S   
Sbjct: 3108 ASTPTHSSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTY 3167

Query: 1410 HSVLAEEDKVAIKGASPIETSSKHLAWS-----EAEKEIKFDSLPSVSSIAEHSVLSEVE 1464
            HS              P  T + H + S      +E+     S P  +  A     S   
Sbjct: 3168 HS-------------RPSSTPTTHFSASSTTLGRSEESTTVHSSPGATGTALFPTRS--- 3211

Query: 1465 AKEVKAGLPVIKTSSSQHSD------KSEEARVEDKQDLLFSTVCDSERLVSSQKKSLMS 1518
            A  V  G P     SS  ++       +  A + +K    +S+    +  +S    +   
Sbjct: 3212 ATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSG 3271

Query: 1519 TSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKD------EETASS-SP 1571
             SE     H  P S         T +P     S AS H  P   D        TASS  P
Sbjct: 3272 VSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTAS-HSSPGSTDTTLSPGSTTASSLGP 3330

Query: 1572 ELENLASGLAPTLLLLSDDKNKPA--VEVSSTAQGDFPSEKQDVALAELSLE-------- 1621
            E     SG   T   L  D    +  +E S+       S    ++ A  +          
Sbjct: 3331 ESTTFHSGPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQ 3390

Query: 1622 --PEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSR 1679
              P  KD    P   P   S F        GS     + +P T    S    G    RS 
Sbjct: 3391 SWPNSKDTTPAP---PTTTSAFVELSTTSHGS----PSSTPTTHFSASSTTLG----RSE 3439

Query: 1680 EGKEENRELCASSTMPA-ISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNP 1738
            E    +    A++T P+     +S L EES      P S + +      P +    G   
Sbjct: 3440 ESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHF----PESDTTSGRGE 3495

Query: 1739 EEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPN 1798
            E     + +   +S   S  +   +           T             +  E T   +
Sbjct: 3496 ESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHS 3555

Query: 1799 SSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMR 1858
            S     +I  P++   S LL E   +  +  S +T  LP  +T+       G+ + S   
Sbjct: 3556 SQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTP------GLSEKSTTF 3609

Query: 1859 ENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDS 1918
             + P   +    T  PA    +                G  E   + H +   GS    +
Sbjct: 3610 HSSPRSPA---TTLSPASTTSS----------------GVSEESTTSHSR--PGSTHTTA 3648

Query: 1919 SSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSK 1978
               +   PG  + + +S          +LP S   S  SSQE+ ++  +SSG+T+T  S 
Sbjct: 3649 FPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSG-SSQESTTS-HSSSGSTDTALSP 3706

Query: 1979 ------SYSSEEVKLAEEPKS----LVLAGNVERNIAEGK-EIHSLMESESLLLEKANTE 2027
                  S+  E       P S    L         I E    +HS   S    L  A++ 
Sbjct: 3707 GSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASST 3766

Query: 2028 LSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETI---SSSVKTAHFPAEGVEPALG 2084
                  E +  +           P S  +    +S T      S  T HFPA        
Sbjct: 3767 SPGLQGESTAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHS 3826

Query: 2085 NEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKI---PTQRKPISSIHAR 2141
             +     S+P      P         +           S E+      T    +S     
Sbjct: 3827 EKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTT 3886

Query: 2142 EPQSPESPEVTQNP 2155
               SP SP  T +P
Sbjct: 3887 FYSSPRSPTTTLSP 3900



 Score = 89.4 bits (220), Expect = 7e-17
 Identities = 425/2283 (18%), Positives = 713/2283 (31%), Gaps = 258/2283 (11%)

Query: 82   GITWETNSSRSSTPWASE-----ESQTSGVCSREGSTVNSPPGNVS---FIVDEVKKVRK 133
            G++ E+ +  SS+P ++E      S T+ V   E +T +S P +     F  D       
Sbjct: 2852 GLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLT 2911

Query: 134  RTHKSKHGSPSLRRKG----------NRKRNSFESQDVPTNKKGSPLTSASQVLTTEKEK 183
                +  GSP+  + G            +  +F S    T    SP  S +  L  E   
Sbjct: 2912 EESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTP 2971

Query: 184  SYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQ 243
            S       +  + TT    P T ++ ++       P              S    L P  
Sbjct: 2972 SRLS---PSSTETTTLPGSPTTPSLSEKSTTFYTSP-------------RSPDATLSP-- 3013

Query: 244  FYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVFPPW 303
               T     V +E      +  S       D++ ++ +S+       S       + P  
Sbjct: 3014 --ATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPGS 3071

Query: 304  RGALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQSV 363
              A S G +S T   S  D +          +  +E + P++SS+G     +    S S 
Sbjct: 3072 TTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSA 3131

Query: 364  PQQPEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANEVK 423
              Q E             TP  P T            + P +  + + S+ S +     +
Sbjct: 3132 GLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEE 3191

Query: 424  KEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSVKGE 483
               V+S          SPG   +T   L P +     TS+   EP       T P   G 
Sbjct: 3192 STTVHS----------SPG---ATGTALFPTRSA---TSVLVGEPT------TSPISSGS 3229

Query: 484  KEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVS 543
             E   L P  + +  L          E S     +P   D+ L            S  VS
Sbjct: 3230 TETTAL-PGSTTTAGLS---------EKSTTFYSSPRSPDTTLSPASTT------SSGVS 3273

Query: 544  EKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQD 603
            E+    H  P   H         +   S E  A          ++S GS   S       
Sbjct: 3274 EESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPEST 3333

Query: 604  LNHELQEQEGEPVPPSNVEA---IAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEK 660
              H         + P N  A   +     +           SPA + T +   +   +  
Sbjct: 3334 TFHSGPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWP 3393

Query: 661  TSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSP 720
             S++ +P   T T  ++     E S +   +P ST  + +S  S     S + T    SP
Sbjct: 3394 NSKDTTPAPPTTTSAFV-----ELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSP 3448

Query: 721  LILKGVSEYMIPSEEKEDTG-----SFTPAVAPASEPSLS-PSTTEKTSECQSPLPSTAT 774
                 V+    PS  +  T      S T   +P S  ++  P +   +   +    S ++
Sbjct: 3449 -----VATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSS 3503

Query: 775  SEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLS 834
            + H + S      +    P S     Y +   +T  +     +  S    +  + H+   
Sbjct: 3504 TTHTISSAPSTTSALVEEPTS-----YHSSPGSTATTHFPDSSTTSGRSEESTASHSSQD 3558

Query: 835  VDGKEVIGPSSPDLVVASEHSFPP------HTTEMTSECQAPPLSATPSEYVVLSDEEAV 888
              G  V+   S   V+  E +  P       TT +      P LS   + +       A 
Sbjct: 3559 ATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPAT 3618

Query: 889  ELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPD 948
             L   + +S+  SE S   ++ P +        S    G S     S        P S D
Sbjct: 3619 TLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSS-----PGSTD 3673

Query: 949  SAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSI 1008
            +  +   +    ++QE+        S     SP   T LS          SP S      
Sbjct: 3674 TTLLPASTTTSGSSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLF 3733

Query: 1009 PPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAET 1068
            P    S T    +E  + + + + S  +  S A      S+ +  +  + ++ Q   A T
Sbjct: 3734 PD---STTSSGIVEASTRVHSSTGSPRTTLSPA------SSTSPGLQGESTAFQTHPAST 3784

Query: 1069 FPLMSPLEDLSLPPSTDKSEKAEIKP-EIPTTSTSVSEYLILAQKQKTQAYLEPESEDLI 1127
                SP    + P   ++S      P   PTT    S       ++ T  +  P++    
Sbjct: 3785 HTTPSPPSTATAP--VEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTT 3842

Query: 1128 PSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPT 1187
            PS   S         +S ++      P  + I        +P  +   S       + PT
Sbjct: 3843 PSSAHSTTSGRGESTTSRIS------PGSTEITTLPGSTTTP-GLSEASTTFYSSPRSPT 3895

Query: 1188 AALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMV 1247
              L+       M    V +E     SQ  + H +        P    ES   YS  P   
Sbjct: 3896 TTLS----PASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGST 3951

Query: 1248 DEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDS 1307
            +             V        + + EP           T+L   ++ ++   E    +
Sbjct: 3952 ET-----------TVFPRSTTTSVRREEPTTFHSRPASTHTTLFTEDSTTSGLTE--EST 3998

Query: 1308 KITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTK-LDSNLT 1366
                +P    +         + G  +  F + S     ++ P+ STT+  V +   S L+
Sbjct: 3999 AFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLS 4058

Query: 1367 RAVKEEIPTDSSLITPV--DRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGA 1424
             +  E      S  TP   ++            + L P  T++   S ++EE   +    
Sbjct: 4059 PSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTS---SGVSEESSTSHSQP 4115

Query: 1425 SPIETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSD 1484
                T+    A+ ++         P+ S  ++ S  + +      A   + + S++ HS 
Sbjct: 4116 GSTHTT----AFPDSTTTSGLSQEPTTSHSSQGSTEATLSPGSTTAS-SLGQQSTTFHSS 4170

Query: 1485 KSEEARVEDKQDLLFSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETEL 1544
              +        D + S + ++     S   SL +T   L P       L  E    ++  
Sbjct: 4171 PGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTT---LTPASSTSTGLQEESTTFQS-W 4226

Query: 1545 PSSQNVSPASKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQG 1604
            PSS + +P+         +  T   S       +  + +   L   +    V  S  A G
Sbjct: 4227 PSSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATG 4286

Query: 1605 D--FPSEKQ-DVALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAK--- 1658
               FP+     V + E +  P       +   LP  GS  ++ L  +S +  +       
Sbjct: 4287 TALFPTRSATSVLVGEPTTSPISSGST-ETTALP--GSTTTAGLSEKSTTFYSSPRSPDT 4343

Query: 1659 --SPITETEDSVLEKGPAELRSREGKEENRELCASSTMPAISELSSLLREE--SQNEEIK 1714
              SP + T   V E+      SR G        +S+TMP +S+ S+       S +  + 
Sbjct: 4344 TLSPASTTSSGVSEESTTS-HSRPGSMHTTAFPSSTTMPGVSQESTASHSSPGSTDTTLS 4402

Query: 1715 PFSPKIISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGG--------- 1765
            P S    SL  +      + G       P   +  GL E  S P     G          
Sbjct: 4403 PGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLE-ASTPVHSSTGSPHTTLSPAG 4461

Query: 1766 ----------------NQEIGPLPPTGN-----LKAQVMGDILDK-------------LS 1791
                            +++  P PPT       L     G                   S
Sbjct: 4462 STTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRS 4521

Query: 1792 EETGHPNSSQVLQSIT-EPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLG 1850
            EE+   +SS V  + T  P++   S L+ E      +  S QT+  P+ +T+S   ++  
Sbjct: 4522 EESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRGEEST 4581

Query: 1851 IKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPE-NVASQHEQR 1909
                S          + S +  +P     +          D +   G+ E + AS   Q 
Sbjct: 4582 TSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQD 4641

Query: 1910 IAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAV------- 1962
              G++ L + S+  +  G+   + +S   +  +    LP S     LS +          
Sbjct: 4642 ATGTIVLPARSTTSVLLGE---STTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPSS 4698

Query: 1963 ------SALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSL--M 2014
                  SA  T+ G +E  ++   S         P     +G VE + A      S   M
Sbjct: 4699 TPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTM 4758

Query: 2015 ESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHF 2074
                       +E S  S   +   I  PP        S L  E     +   S+ T HF
Sbjct: 4759 HFPESSTASGRSEESRTSHSSTTHTISSPPST-----TSALVEEPTSYHSSPGSIATTHF 4813

Query: 2075 PAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKP 2134
            P          E  A  S+P      PL        ++ +       P            
Sbjct: 4814 PESSTTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIAESTTFYISPGSMETTLASTAT 4873

Query: 2135 ISSIHAREP---QSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGSST 2191
               + A+      S  SP+ T +P +    +    P        S  +S  ++ F  S+T
Sbjct: 4874 TPGLSAKSTILYSSSRSPDQTLSPASMTSSSISGEPTSL----YSQAESTHTTAFPASTT 4929

Query: 2192 PDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEPRG 2251
                  E     ++P        T + P G+I T+    E    HS     L T   P  
Sbjct: 4930 TSGLSQESTTFHSKPG----STETTLSP-GSITTSSFAQEFTTPHSQPGSALSTV-SPAS 4983

Query: 2252 TLV 2254
            T V
Sbjct: 4984 TTV 4986



 Score = 83.6 bits (205), Expect = 4e-15
 Identities = 437/2221 (19%), Positives = 682/2221 (30%), Gaps = 383/2221 (17%)

Query: 75   TVQREDSGITWETNSSRSST-PWASEESQT-------------------SGVCSREGSTV 114
            T  R   G T  T S  S+T P  SEES T                   + V   E +T 
Sbjct: 1273 TTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTF 1332

Query: 115  NSPPGNVS---FIVDEVKKVRKRTHKSKHGSPSLRRKG----------NRKRNSFESQDV 161
            +S P +     F  D           +  GSP+  + G            +  +F S   
Sbjct: 1333 HSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSG 1392

Query: 162  PTNKKGSPLTSASQVLTTEKEKSYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLRPVY 221
             T  K SP  S +  L  E   S       +  + TT    P T ++ ++       P  
Sbjct: 1393 STGTKLSPARSTTSGLVGESTPSRLS---PSSTETTTLPGSPTTPSLSEKSTTFYTSP-- 1447

Query: 222  IGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTV 281
                        S    L P     T     V +E      +  S       D++ ++ +
Sbjct: 1448 -----------RSPDATLSP----ATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSDL 1492

Query: 282  SKTRKLVAQSIEDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHT 341
            S+       S       + P    A S G +S T   S  D +          +  +E +
Sbjct: 1493 SQEPTTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEAS 1552

Query: 342  VPSYSSSGRAEQGIQLRHSQSVPQQPEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELA 401
             P++SS+G     +    S S   Q E             TP  P T            +
Sbjct: 1553 TPTHSSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHS 1612

Query: 402  SPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLT 461
             P +  + + S+ S +     +   V+S          SPG   +T   L P +     T
Sbjct: 1613 RPSSTPTTHFSASSTTLGRSEESTTVHS----------SPG---ATGTALFPTR---SAT 1656

Query: 462  SIERAEPVSAKLTPTHPSVKGEKEENMLEPSIS---LSEPLMLEEPEKEEIETSLPIAIT 518
            S+   EP       T P   G  E   L  S +   LSE            +T+L  A T
Sbjct: 1657 SVLVGEPT------TSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPAST 1710

Query: 519  PEPEDSNLVEEEIVELDYPES------------PLVSEKPFPPHMSP------------- 553
                 S + EE       P S            P VS++    H SP             
Sbjct: 1711 ---TSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLSPGSTT 1767

Query: 554  ------------EVEHKEEELILP-------LLAASSPEHVALSEEEREEIASVSTGSAF 594
                              E  +LP       LL AS+P H +          + ST    
Sbjct: 1768 ASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGST---- 1823

Query: 595  VSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLS 654
             +              ++  P PP+   A  E +  S          SP++ PT+  S S
Sbjct: 1824 -TRQGESTTFQSWPSSKDTMPAPPTTTSAFVELSTTSHG--------SPSSTPTTHFSAS 1874

Query: 655  PST----TEKTSENQSPLFSTVTP------------EYMVLSGDEASESGCYTPDSTSAS 698
             +T     E T+ + SP+ +  TP            E         S    + P+S++AS
Sbjct: 1875 STTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTAS 1934

Query: 699  EYSVPSLATKESLKKTI----DRKSPLILKGVSEYMIP-----------------SEEKE 737
              S  S  +  S   TI       S L+ +  S +  P                 SEE  
Sbjct: 1935 GRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEEST 1994

Query: 738  DTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSEGEDLG-SERFTPDSK 796
             + S   A      P+ S ++        SP+ S +     +P      G SE+ T    
Sbjct: 1995 ASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFHS 2054

Query: 797  LISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKEVIG-----------PSS 845
                 A  L+    +   +  E++    +  S HT    D     G           P S
Sbjct: 2055 SPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGS 2114

Query: 846  PD--LVVASEHSFPPHTTEMTSECQ--APPLSATPSEYVVLSDEEAVELERYTPSSTSAS 901
             D  L+ AS  +  P     TS     +   + +P     LS  +       +P ST  +
Sbjct: 2115 TDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTT 2174

Query: 902  EFSVPPYATPEAQEEEIVHRSL---------------NLKGAS--------------SPM 932
             F     ++   +    VH S                 L+G S              SP 
Sbjct: 2175 LFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPP 2234

Query: 933  NLSEEDQEDIGPF--SPDSAFVSEFSFPPYATQEAEKREFECDSPIC--LTSPSEHTILS 988
            + +    E+   +  SP S   + F      +  +EK      SP     T  S H+  S
Sbjct: 2235 STATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTS 2294

Query: 989  DEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGS 1048
                      SP S    ++P    S T     E  +   +   S  +  S A    +G 
Sbjct: 2295 GRGESTTSRISPGSTEITTLPG---STTTPGLSEASTTFYSSPRSPTTTLSPASMTSLG- 2350

Query: 1049 TAATPVSEQFSSSQKQKAETFPLMSPL---------EDLSLPPSTDKSEKAEIKPEIPTT 1099
                 V E+ ++S+ Q   T   +SP          E  ++  S+  S +  + P  PTT
Sbjct: 2351 -----VGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRTPTT 2405

Query: 1100 STSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSI 1159
            S    E       +    +    +ED   S LT E        +S+   +PA L      
Sbjct: 2406 SVRGEEPTTF-HSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLG 2464

Query: 1160 VKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAH 1219
             +  T P+S  S      PA    +  T+ L  ++   +++          P S E T  
Sbjct: 2465 EESTTFPSSSGSTGTTLSPA----RSTTSGLVGESTPSRLS----------PSSTETTT- 2509

Query: 1220 VSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVI 1279
                    P  P  P    K +        P   + P    + +   E+   S ++P   
Sbjct: 2510 -------LPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTS-SGVSEESSTSHSQPGST 2561

Query: 1280 KPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSAL 1339
               +    T+  G    S         +  T  P    ++    E    H  P    +AL
Sbjct: 2562 HTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTAL 2621

Query: 1340 SEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDR-------PVLTKVG 1392
            S      +     +TT   +   ++ T  +  +  T S ++    R       P  T   
Sbjct: 2622 SPGSTTALSFGQESTTFHSSPGSTHTT--LFPDSTTSSGIVEASTRVHSSTGSPRTTLSP 2679

Query: 1393 KGELGSGLPPLVTSADEHSVLAEEDKVAIKGA-SPIETSSKHLAWSEAEKEIKFDSLPSV 1451
                  GL    T+   H             A +P+E S+    +  +         P+ 
Sbjct: 2680 ASSTSPGLQGESTTFQTHPASTHTTPSPPSTATAPVEEST---TYHRSPGSTPTTHFPAS 2736

Query: 1452 SSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSS 1511
            S+ + HS  S +      A      T SS HS  S             ST   S     S
Sbjct: 2737 STTSGHSEKSTIFHSSPDAS---GTTPSSAHSTTSGRGE---------STT--SRISPGS 2782

Query: 1512 QKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSSP 1571
             + + +  S       E   + +   +   T L      SPAS   +  G++  T+ S P
Sbjct: 2783 TEITTLPGSTTTPGLSEASTTFYSSPRSPTTTL------SPASMTSLGVGEESTTSRSQP 2836

Query: 1572 -ELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKDKPHQ 1630
                +  S  + T   LS++        S+T     P   +       +    + ++P  
Sbjct: 2837 GSTHSTVSPASTTTPGLSEE--------STTVYSSSPGSTETTVFPRSTTTSVRGEEPTT 2888

Query: 1631 PLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRELCA 1690
                P   S  ++     S + G  +  +    +  S     PA L + +  EE+    +
Sbjct: 2889 FHSRP--ASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPS 2946

Query: 1691 SS------TMPAISELSSLLRE--------ESQNEEIKPFSPKIISLESKEPPASVAEGG 1736
            SS        PA S  S L+ E         S      P SP   SL  K      +   
Sbjct: 2947 SSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRS 3006

Query: 1737 NPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGH 1796
                  P T +  G+SEE S      + G+      P +              LS+E   
Sbjct: 3007 PDATLSPATTTSSGVSEESS--TSHSQPGSTHTTAFPDSTTTSG---------LSQEPTA 3055

Query: 1797 PNSSQ-VLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFS 1855
             +SSQ   ++   P     S L  +      +    +T  LPD + +S            
Sbjct: 3056 SHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITS-----------G 3104

Query: 1856 LMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQ 1915
            L+  + P   S   + T       T                      A   E+       
Sbjct: 3105 LVEASTPTHSSTGSLHTTLTPASSTS---------------------AGLQEESTTFQSW 3143

Query: 1916 LDSSSSNELRPGQLKA--AVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTE 1973
              SS +    PG   A   VS+  H+          SA  + L   E  + + +S G T 
Sbjct: 3144 PSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATG 3203

Query: 1974 TLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSK 2033
            T    + S+  V + E   S + +G+ E     G        + + L EK+ T  S P  
Sbjct: 3204 TALFPTRSATSVLVGEPTTSPISSGSTETTALPGS------TTTAGLSEKSTTFYSSPRS 3257

Query: 2034 EDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRST 2093
             D+     L P        SG+S E   S +   S  T  FP     P +  E  A  S+
Sbjct: 3258 PDT----TLSPA---STTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSS 3310

Query: 2094 P 2094
            P
Sbjct: 3311 P 3311



 Score = 78.2 bits (191), Expect = 2e-13
 Identities = 470/2370 (19%), Positives = 726/2370 (30%), Gaps = 364/2370 (15%)

Query: 69   PSFSMVTVQREDSGITWETNSSRS----STPWASEESQTSGVCSREGSTVNSPPGNV--- 121
            P+ ++       SG++ E+ +SRS    +   A  +S T+   SR  +T +S PG+    
Sbjct: 976  PATTLSPASTTSSGVSEESTTSRSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTT 1035

Query: 122  ----SFIVDEVKKVRKRTHKSKHGSPSLRRKGNRKRNSFESQDVPTNKK-GSPLTSASQV 176
                S       +    +H S   + +    G+    SF  +    +   GS  T+    
Sbjct: 1036 LLPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPD 1095

Query: 177  LTTEKE--KSYTGIYDKARKKKTTSNTPPITG-AIYKEHKPLVLRPVYIGTVQYKIKMFN 233
             TT     ++ T ++      +TT +    T   +  E       P    T         
Sbjct: 1096 STTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTAT 1155

Query: 234  S-VKEELIPLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRKLVAQSI 292
            + V+E     +  G+ P  +           + S       D SG+ T S      +   
Sbjct: 1156 APVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGT-TPSSAHSTTSGRG 1214

Query: 293  EDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAE 352
            E     + P      +    + T   S  +    +  SP + T+ L     S +S G  E
Sbjct: 1215 ESTTSRISPGSTEITTLPGSTTTPGLS--EASTTFYSSPRSPTTTLSPA--SMTSLGVGE 1270

Query: 353  QGIQLRHSQSVPQQPEDEAKPHEVEPPSVTPD-----------TPATMFLRTTKEECELA 401
            +      S+S P        P     P ++ +           T  T+F  +T       
Sbjct: 1271 ESTT---SRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGE 1327

Query: 402  SPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLEA-ASPGLAASTQDGLDPDQEQPDL 460
             P T  S   S+ +  F  +       S    ++ E+ A PG  ASTQ GL       DL
Sbjct: 1328 EPTTFHSRPASTHTTLFTED-------STTSGLTEESTAFPGSPASTQTGLPATLTTADL 1380

Query: 461  TSIERAEPVSA-----KLTP---THPSVKGEKEENMLEPSISLSEPLMLEEPEKEEIETS 512
                   P S+     KL+P   T   + GE   + L PS + +  L          E S
Sbjct: 1381 GEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKS 1440

Query: 513  LPIAITPEPEDSNLVEEEIVELDYPESPLVSEKPFPPHMSPEVEHKEEELILPLLAASSP 572
                 +P   D+ L            S  VSE+    H  P   H          +  S 
Sbjct: 1441 TTFYTSPRSPDATLSPATTT------SSGVSEESSTSHSQPGSTHTTAFPDSTTTSDLSQ 1494

Query: 573  EHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSN--VEAIAEHAVL 630
            E       +    A++S GS   S         H         + P +     + E +  
Sbjct: 1495 EPTTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTP 1554

Query: 631  SEEENEEFEAYSPAAAPTSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCY 690
            +             A+ TS      STT ++  + S   +T +P     +  E S +   
Sbjct: 1555 THSSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSD--TTPSPPGTTAAPVEVSTTYHS 1612

Query: 691  TPDSTSASEYSVPSLATKESLKKTIDRKSP-------LILKGVSEYMI--PSEEKEDTGS 741
             P ST  + +S  S     S + T    SP          +  +  ++  P+     +GS
Sbjct: 1613 RPSSTPTTHFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGS 1672

Query: 742  FTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSEG--EDLGSERFTPDSKLIS 799
                  P S  +   S    T       P T  S     S G  E+  +    P S   +
Sbjct: 1673 TETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTT 1732

Query: 800  KYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKEV--IGPSS------------ 845
             +         SQ+   + +S       S  T LS        +GP S            
Sbjct: 1733 AFPGSTTMPGVSQESTASHSSPG-----STDTTLSPGSTTASSLGPESTTFHSSPGSTET 1787

Query: 846  ---PDLVVAS---EHSFP-------PHTT-----EMTSECQAPPLSATPSEYVVL----- 882
               PD   AS   E S P       PHTT       T + ++    + PS    +     
Sbjct: 1788 TLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPSSKDTMPAPPT 1847

Query: 883  SDEEAVEL---ERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQ 939
            +    VEL      +PSST  + FS        ++E   VH S  +  A++P        
Sbjct: 1848 TTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSS-PVATATTPSPARSTTS 1906

Query: 940  ---EDIGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAE 996
               E+   +           FP  +T      E          S + HTI S   T  A 
Sbjct: 1907 GLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSH-----SSTTHTISSPPSTTSAL 1961

Query: 997  L-------FSPDSASQVSIPPF-----RISETEKNELEPDSLLTAV-----------SAS 1033
            +        SP S +    P       R  E+  +    D+  T V             S
Sbjct: 1962 VEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGES 2021

Query: 1034 GYSCFSEADEEDI---GSTAATPVSEQ---FSSSQKQKAETFPLMSPLEDLSLPPSTDKS 1087
              S  S    E     GST    +SE+   F SS +  A T   +SP    S   S + +
Sbjct: 2022 TTSPISSGSMETTALPGSTTTPGLSEKSTTFHSSPRSPATT---LSPASTTSSGVSEEST 2078

Query: 1088 EKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESED--LIPSHLTSEVEKGEREAS-S 1144
                      TT+   S       +  T ++  P S D  L+P+  T+     E   S S
Sbjct: 2079 TSHSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHS 2138

Query: 1145 SVAAIPAALPAQS----SIVKEET----KPASPHSVL-PDS------VPAIKKEQEPTAA 1189
            S  +   AL   S    S  +E T     P S H+ L PDS      V A  +    T +
Sbjct: 2139 SPGSTDTALSPGSTTALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGS 2198

Query: 1190 LTLKAADEQMALSKVRKEEIVPDSQEATAH------------VSQDQKMEPQPPNVPESE 1237
                 +        ++ E     +  A+ H            V +       P + P + 
Sbjct: 2199 PRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTH 2258

Query: 1238 MKYSVLPDMVDEPK---------KGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKET 1288
               S       E            G  P    + TS   +   S+  P   +  +    T
Sbjct: 2259 FPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGST 2318

Query: 1289 SLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFS----------A 1338
            +  G    S            T +P  + S   G E       P    S           
Sbjct: 2319 TTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPG 2378

Query: 1339 LSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPT----------------DSSLITP 1382
            LSEE       SSS  +   T      T +V+ E PT                DS+    
Sbjct: 2379 LSEE--STTVYSSSPGSTETTVFPRTPTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGL 2436

Query: 1383 VDRPVLTKVGKGELGSGLPPLVTSAD---EHSVLAEEDKVAIKGASPIETSSKHLAWSEA 1439
             +             +GLP  +T+AD   E +             SP  +++  L     
Sbjct: 2437 TEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGEST 2496

Query: 1440 EKEIKFDSL--------PSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARV 1491
               +   S         P+  S++E S       +   A L    T+SS  S++S  +  
Sbjct: 2497 PSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHS 2556

Query: 1492 E--DKQDLLF---STVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPS 1546
            +        F   +T     R  ++   S  ST   L P          E     +   S
Sbjct: 2557 QPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGS 2616

Query: 1547 SQN-VSPASKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGD 1605
            +   +SP S   +  G++  T  SSP       G   T L      +   VE S+     
Sbjct: 2617 TDTALSPGSTTALSFGQESTTFHSSP-------GSTHTTLFPDSTTSSGIVEASTRVHSS 2669

Query: 1606 FPSEKQDVALAE------------LSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIG 1653
              S +  ++ A                 P        P     A  E S+   R  GS  
Sbjct: 2670 TGSPRTTLSPASSTSPGLQGESTTFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTP 2729

Query: 1654 T-----------KQAKSPITETEDSVLEKGPAELRS-------------REGKEENRELC 1689
            T              KS I  +        P+   S               G  E   L 
Sbjct: 2730 TTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLP 2789

Query: 1690 ASSTMPAISELSSLL--REESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQPFTFS 1747
             S+T P +SE S+       S    + P S   + +  +   +    G       P + +
Sbjct: 2790 GSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTT 2849

Query: 1748 LKGLSEEVSHPADFKKGGNQ-EIGPLPPTGNLKAQ-----------------VMGDILDK 1789
              GLSEE +       G  +  + P   T +++ +                         
Sbjct: 2850 TPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSG 2909

Query: 1790 LSEE-TGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQD 1848
            L+EE T  P S    Q+   P+ +  +DL  E      +  S  T   P  ST+S     
Sbjct: 2910 LTEESTAFPGSPASTQT-GLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTS----- 2963

Query: 1849 LGIKQFSLMRENLP--LEQSKSFMTTKPADVKETKMEE----FFISPKDENWMLGKPENV 1902
                   L+ E+ P  L  S +  TT P       + E    F+ SP+  +  L      
Sbjct: 2964 ------GLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTT 3017

Query: 1903 ASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAV 1962
            +S   +  + S     S+     P     +  S++ T         HS++ S  ++    
Sbjct: 3018 SSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTAS-------HSSQGSTEATLSPG 3070

Query: 1963 SALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSL-------ME 2015
            S   +S G   T    S    E  L   P   + +G VE +        SL         
Sbjct: 3071 STTASSLGQQSTTFHSSPGDTETTLL--PDDTITSGLVEASTPTHSSTGSLHTTLTPASS 3128

Query: 2016 SESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETI----SSSVKT 2071
            + + L E++ T  SWPS  D+      PP         G +   V+  T      SS  T
Sbjct: 3129 TSAGLQEESTTFQSWPSSSDTTPS---PP---------GTTAAPVEVSTTYHSRPSSTPT 3176

Query: 2072 AHFPAEGVEPALGNEKEAHRSTPP------FPEEKPLEESKMVQSKVIDDADEGKKPSPE 2125
             HF A         E     S+P       FP       S +V          G   +  
Sbjct: 3177 THFSASSTTLGRSEESTTVHSSPGATGTALFPTRS--ATSVLVGEPTTSPISSGSTETTA 3234

Query: 2126 VKIPTQRKPISSIHAREPQSPESPEVTQNP 2155
            +   T    +S        SP SP+ T +P
Sbjct: 3235 LPGSTTTAGLSEKSTTFYSSPRSPDTTLSP 3264



 Score = 75.5 bits (184), Expect = 1e-12
 Identities = 364/1867 (19%), Positives = 605/1867 (32%), Gaps = 243/1867 (13%)

Query: 308  SKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQSVPQQP 367
            S G ES T   S    K          +  LE + P +SS+G     +    S +   +P
Sbjct: 359  SLGPESTTFHSSPGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPSSSTTHEGEP 418

Query: 368  ED-EAKPHEVEP-PSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKE 425
               ++ P   +  P+ +  T A + L TT      ++P T  S + +++  S       E
Sbjct: 419  TTFQSWPSSKDTSPAPSGTTSAFVKLSTTYHSSPSSTPTTHFSASSTTLGHS-------E 471

Query: 426  DVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLT-PTHPSVKGEK 484
            +    H S    A +P  A S   G        + T+  R+   +  +  P   +  G  
Sbjct: 472  ESTPVHSSPVATATTPPPARSATSG-----HVEESTAYHRSPGSTQTMHFPESSTTSGHS 526

Query: 485  EENML----EPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESP 540
            EE+            S P            +SL    T    DS+ +             
Sbjct: 527  EESATFHGSTTHTKSSTPSTTAALAHTSYHSSLGSTETTHFRDSSTISGR---------- 576

Query: 541  LVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSV 600
              SE+    H SP+       +   +L A S   V + +     I+S S  +  +   + 
Sbjct: 577  --SEESKASHSSPDA------MATTVLPAGSTPSVLVGDSTPSPISSGSMETTALPGSTT 628

Query: 601  PQDLNHELQEQEGEPVPPSNV-------------EAIAEHAVLSEEENEEFEAYSPAAAP 647
               L+ +       P  P                E+   H+         F   +     
Sbjct: 629  KPGLSEKSTTFYSSPRSPDTTHLPASMTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGL 688

Query: 648  TSESSLS---PSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSAS---EYS 701
            + ES+ S   P  T+ T    S   S++ PEY        S      PD+T+AS   E S
Sbjct: 689  SQESTASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTETTLLPDNTTASGLLEAS 748

Query: 702  VPSLATKESLKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPA---------SEP 752
            +P  ++  S   T+        +G S         +DT    P    A           P
Sbjct: 749  MPVHSSTRSPHTTLSPAGSTTRQGESTTFHSWPSSKDTRPAPPTTTSAFVEPSTTSHGSP 808

Query: 753  SLSPSTTEKTSECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQ 812
            S  P+T        S L   +T+ H  P   + +      P+S   S        +  S 
Sbjct: 809  SSIPTTHISARSTTSGLVEESTTYHSSPGSTQTM----HFPESDTTSGRGEESTTSHSST 864

Query: 813  KKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLVVAS---EHSFPPHTTEMTSECQA 869
               I+ A       + E T              PD    S   E S   H+++  +    
Sbjct: 865  THTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIV 924

Query: 870  PPLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYAT--PEAQEEEIVHRSLNLKG 927
             P  +T S   VL  E        +P S+ + E +  P +T  P   E      S     
Sbjct: 925  LPARSTTS---VLLGESTT-----SPISSGSMETTALPGSTTTPGLSERSTTFHSSPRSP 976

Query: 928  ASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSP--SEHT 985
            A++           + P S  S+ VSE S    +   +       DS    T+P  S H+
Sbjct: 977  ATT-----------LSPASTTSSGVSEESTTSRSRPGSTHTTAFPDST---TTPGLSRHS 1022

Query: 986  ILSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEAD--E 1043
              S       +     +++  S P    + +  +    D+ L+  S +  S   E+    
Sbjct: 1023 TTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFH 1082

Query: 1044 EDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSV 1103
             + GST  T   +  +SS   +A T      +   +  P T  S  +   P +   ST+ 
Sbjct: 1083 SNPGSTHTTLFPDSTTSSGIVEAST-----RVHSSTGSPRTTLSPASSTSPGLQGESTAF 1137

Query: 1104 SEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEE 1163
                   Q      +  P      PS  T+ VE+      S  +      PA S+     
Sbjct: 1138 -------QTHPASTHTTPSP----PSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHS 1186

Query: 1164 TKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQD 1223
             K    HS  PD+         P++A +  +   +   S++      P S E T      
Sbjct: 1187 EKSTIFHSS-PDA-----SGTTPSSAHSTTSGRGESTTSRIS-----PGSTEITTLPGST 1235

Query: 1224 QKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEP-EVIKPY 1282
                   P + E+   +   P     P   + P  + ++    E+   S+++P       
Sbjct: 1236 TT-----PGLSEASTTFYSSPR---SPTTTLSPASMTSLGVG-EESTTSRSQPGSTHSTV 1286

Query: 1283 SPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSALSEE 1342
            SP   T+    E  + V    +  ++ T  P    ++  G E    H  PA   + L  E
Sbjct: 1287 SPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTTLFTE 1346

Query: 1343 ------IKKEIEPSSSTTTASVTKLDSNLTRA-VKEEIPTDSSLITPVDRPVLTKVGKGE 1395
                  + +E      +  ++ T L + LT A + EE  T  S               G 
Sbjct: 1347 DSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPS-------------SSGS 1393

Query: 1396 LGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPSVSSIA 1455
             G+ L P  ++    S L  E   +    S  ET++                 P+  S++
Sbjct: 1394 TGTKLSPARSTT---SGLVGESTPSRLSPSSTETTT-------------LPGSPTTPSLS 1437

Query: 1456 EHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVE--DKQDLLF---STVCDSERLVS 1510
            E S       +   A L    T+SS  S++S  +  +        F   +T  D  +  +
Sbjct: 1438 EKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSDLSQEPT 1497

Query: 1511 SQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSS 1570
            +   S  ST   L P      SL G+        P     +      I  G  E +  + 
Sbjct: 1498 TSHSSQGSTEATLSPGSTTASSL-GQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTH 1556

Query: 1571 PELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDV--------ALAELSL-- 1620
                +L + L P             ++  ST    +PS             A  E+S   
Sbjct: 1557 SSTGSLHTTLTPA------SSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTY 1610

Query: 1621 --EPEKKDKPHQPLELPNAG-SEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELR 1677
               P      H        G SE S+ +    G+ GT  A  P T +  SVL   P    
Sbjct: 1611 HSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGATGT--ALFP-TRSATSVLVGEPTTSP 1667

Query: 1678 SREGKEENRELCASSTMPAISELSSLLREESQNEE--IKPFSPKIISLESKEPPASVAEG 1735
               G  E   L  S+T   +SE S+      ++ +  + P S     +  +   +    G
Sbjct: 1668 ISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPG 1727

Query: 1736 GNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETG 1795
                   P + ++ G+S+E +  A     G+ +    P  G+  A  +G       E T 
Sbjct: 1728 STHTTAFPGSTTMPGVSQEST--ASHSSPGSTDTTLSP--GSTTASSLGP------ESTT 1777

Query: 1796 HPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFS 1855
              +S    ++   P     S LL        +  S  T   P  ST+ + +     + + 
Sbjct: 1778 FHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAGSTTRQGESTT-FQSWP 1836

Query: 1856 LMRENLPLEQSKS-----FMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRI 1910
              ++ +P   + +       TT       T    F  S    +  LG+ E   + H   +
Sbjct: 1837 SSKDTMPAPPTTTSAFVELSTTSHGSPSSTPTTHFSAS----STTLGRSEESTTVHSSPV 1892

Query: 1911 AGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSG 1970
            A +     S +     G ++ + +        +    P S+  S  S +   S     S 
Sbjct: 1893 ATATT--PSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRTS----HSS 1946

Query: 1971 NTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSW 2030
             T T+SS   ++    L EEP S         + + G    +     S    ++    + 
Sbjct: 1947 TTHTISSPPSTTSA--LVEEPTSY--------HSSPGSTATTHFPDSSTTSGRSEESTAS 1996

Query: 2031 PSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAH 2090
             S +D+   I LP     +   S L  E   S   S S++T   P     P L  +    
Sbjct: 1997 HSSQDATGTIVLPA----RSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTF 2052

Query: 2091 RSTPPFP 2097
             S+P  P
Sbjct: 2053 HSSPRSP 2059



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 415/2082 (19%), Positives = 646/2082 (31%), Gaps = 346/2082 (16%)

Query: 330  SPLNATS--ALEHTVPSYSSSGRAEQGIQLRHSQSVPQQPEDEAKPHEVEPPSVTPDTPA 387
            SP + TS    E +  S S  G     +    S + P   E+    +   P S    T  
Sbjct: 2342 SPASMTSLGVGEESTTSRSQPGSTHSTVSPA-STTTPGLSEESTTVYSSSPGS----TET 2396

Query: 388  TMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLEA-ASPGLAAS 446
            T+F RT         P T  S   S+ +  F  +       S    ++ E+ A PG  AS
Sbjct: 2397 TVFPRTPTTSVRGEEPTTFHSRPASTHTTLFTED-------STTSGLTEESTAFPGSPAS 2449

Query: 447  TQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPS--------VKGEKEENMLEPSISLSEP 498
            TQ GL       DL       P S+  T T  S        + GE   + L PS + +  
Sbjct: 2450 TQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTT 2509

Query: 499  LMLEEPEKEEIETSLPIAITPEPEDSNLV----------EEEIVELDYPES--------- 539
            L          E S     +P   D+ L           EE       P S         
Sbjct: 2510 LPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDS 2569

Query: 540  ---PLVSEKPFPPHMSPEVEHKEEELILPLLAASS---PEHVALSEEEREEIASVSTGSA 593
               P +S      H SP      +  +LP    +S    E             ++S GS 
Sbjct: 2570 TTTPGLSRHSTTSHSSPG---STDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGST 2626

Query: 594  FVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSL 653
                +       H         + P   ++     ++           SP    +  SS 
Sbjct: 2627 TALSFGQESTTFHSSPGSTHTTLFP---DSTTSSGIVEASTRVHSSTGSPRTTLSPASST 2683

Query: 654  SPSTT-EKTSENQSPLFSTVTPEYMVLSGDEASESGCY--TPDSTSASEYSVPSLATKES 710
            SP    E T+    P  +  TP     +     ES  Y  +P ST  + +   S  +  S
Sbjct: 2684 SPGLQGESTTFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHS 2743

Query: 711  LKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPASE-----------PSLSPSTT 759
             K TI   SP    G +     S       S T  ++P S            P LS ++T
Sbjct: 2744 EKSTIFHSSP-DASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEAST 2802

Query: 760  EKTSECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNAT-----QESQKK 814
               S  +SP  + + +       GE+  + R  P S       +P + T     +ES   
Sbjct: 2803 TFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGST--HSTVSPASTTTPGLSEESTTV 2860

Query: 815  IINEASQFKPKGISEHTVLSVDGKEVIG----PSSPDLVVASEHSFPPHTTEMTSECQAP 870
              +     +       T  SV G+E       P+S    + +E S     TE ++     
Sbjct: 2861 YSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGS 2920

Query: 871  PLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASS 930
            P S        L+  +  E     PSS+ ++  ++ P  +  +           L G S+
Sbjct: 2921 PASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTS----------GLVGEST 2970

Query: 931  PMNLSEEDQEDIG-PFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSD 989
            P  LS    E    P SP +  +SE S   Y +           SP    SP+  T    
Sbjct: 2971 PSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPR---------SPDATLSPATTTSSGV 3021

Query: 990  EDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGST 1049
             +        P S    + P              DS  T    SG S    A     GST
Sbjct: 3022 SEESSTSHSQPGSTHTTAFP--------------DSTTT----SGLSQEPTASHSSQGST 3063

Query: 1050 AAT--PVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYL 1107
             AT  P S   SS  +Q           E   LP  T  S   E     PT S++ S + 
Sbjct: 3064 EATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEAST--PTHSSTGSLHT 3121

Query: 1108 ILAQKQKTQAYLE---------PESEDLIPS-------------------------HLT- 1132
             L     T A L+         P S D  PS                         H + 
Sbjct: 3122 TLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSA 3181

Query: 1133 SEVEKGEREASSSVAAIPAA-----LPAQSS----IVKEETKPASPHSVLPDSVP----- 1178
            S    G  E S++V + P A      P +S+    + +  T P S  S    ++P     
Sbjct: 3182 SSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTT 3241

Query: 1179 AIKKEQEPTAALTLKAADEQMA-----LSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNV 1233
            A   E+  T   + ++ D  ++      S V +E     S+  + H +        P   
Sbjct: 3242 AGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVS 3301

Query: 1234 PESEMKYS--------VLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPE--VIKPYS 1283
             ES   +S        + P        G +     +     E   L  N     +++  +
Sbjct: 3302 QESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSGPGSTETTLLPDNTTASGLLEAST 3361

Query: 1284 PLKETSLSGPEALSAVKMEMKHDSKIT---------TTPIVLHSASSGVE-KQVEHGPPA 1333
            P+  ++ S    LS      +     T         TTP    + S+ VE     HG P+
Sbjct: 3362 PVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSPS 3421

Query: 1334 LA----FSALSEEIKKEIEP----SSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDR 1385
                  FSA S  + +  E     SS   TA+      + T  + EE  T  S  +P   
Sbjct: 3422 STPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHS--SPGST 3479

Query: 1386 PVL------TKVGKGELG----SGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLA 1435
              +      T  G+GE      S     ++SA   +    E+  +   +SP  T++ H  
Sbjct: 3480 QTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYH-SSPGSTATTHFP 3538

Query: 1436 WSEAEKEIKFDSLPSVSS--------IAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSE 1487
             S        +S  S SS        +   S  S +  +   + +      ++     + 
Sbjct: 3539 DSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTT 3598

Query: 1488 EARVEDKQDLLFSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSS 1547
               + +K     S+       +S    +    SE     H  P S         T  P S
Sbjct: 3599 TPGLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGST------HTTAFPDS 3652

Query: 1548 QNVSPASKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFP 1607
                  S+H         T+ SSP       G   T LL +      + + S+T+     
Sbjct: 3653 TTTPGLSRH-------STTSHSSP-------GSTDTTLLPASTTTSGSSQESTTSHSS-- 3696

Query: 1608 SEKQDVALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDS 1667
            S   D AL+                     GS  +   G++S +  +    +  T   DS
Sbjct: 3697 SGSTDTALSP--------------------GSTTALSFGQESTTFHSSPGSTHTTLFPDS 3736

Query: 1668 VLEKGPAELRSR----EGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISL 1723
                G  E  +R     G        ASST P +   S+  +    +    P  P   + 
Sbjct: 3737 TTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATA 3796

Query: 1724 ESKEPPA-SVAEGGNPEEFQPFTFSLKGLSEE--VSHPADFKKGGNQEIGPLPPTGNLKA 1780
              +E      + G  P    P + +  G SE+  + H +    G          +G    
Sbjct: 3797 PVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGR--- 3853

Query: 1781 QVMGDILDKLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVS 1840
                          G   +S++    TE + +  S       +     +S    + P  +
Sbjct: 3854 --------------GESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSP--RSPTTT 3897

Query: 1841 TSSEDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPE 1900
             S      LG+ + S    + P     +  T  PA      + E   +    +   G  E
Sbjct: 3898 LSPASMTSLGVGEESTTSRSQP---GSTHSTVSPASTTTPGLSEESTTVYSSS--PGSTE 3952

Query: 1901 NVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCE---VRKQVLPHSAEESHLS 1957
                   +    SV+ +  ++   RP      + ++D T           P S   +   
Sbjct: 3953 TTV--FPRSTTTSVRREEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTG 4010

Query: 1958 SQEAVSALD---------TSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGK 2008
                ++  D         +SSG+T T  S + S+    + E   S +   + E     G 
Sbjct: 4011 LPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGS 4070

Query: 2009 E-----------IHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKP----VS 2053
                         ++   S    L  A T  S  S+E S    +         P     S
Sbjct: 4071 PTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTS 4130

Query: 2054 GLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVI 2113
            GLS E   S +   S +    P      +LG +     S+P   E   L +  +    V 
Sbjct: 4131 GLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLV- 4189

Query: 2114 DDADEGKKP--SPEVKIPTQRKPISSIHAREPQS-------PESPEVTQNPPTQPKVAKP 2164
                E   P  S    + T   P SS      +        P S + T +PP+   V   
Sbjct: 4190 ----EASTPTHSSTGSLHTTLTPASSTSTGLQEESTTFQSWPSSSDTTPSPPSTTAV--- 4242

Query: 2165 DLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQP 2206
              P E      S   S  ++ F  SST   +  E   + + P
Sbjct: 4243 --PVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSP 4282



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 321/1624 (19%), Positives = 530/1624 (32%), Gaps = 281/1624 (17%)

Query: 642  SPAAAPTSESSLSP--STTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASE 699
            SP  + + E++  P  +TT   SE  +  +S+       LS    + SG     +TS S 
Sbjct: 255  SPITSASMETTALPGSTTTAGLSEKSTTFYSSPRSPDRTLSPARTTSSGVSEKSTTSHS- 313

Query: 700  YSVPSLATKESLKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTT 759
                    +     TI       + GVS+        E T S +  +  +++ +LSP TT
Sbjct: 314  --------RPGPTHTIAFPDSTTMPGVSQ--------ESTASHS--IPGSTDTTLSPGTT 355

Query: 760  EKTSECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEA 819
              +S     L   +T+ H  P          +T  ++L      P N T      ++  +
Sbjct: 356  TPSS-----LGPESTTFHSSPG---------YTKTTRL------PDNTTTSG---LLEAS 392

Query: 820  SQFKPKGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEM--TSECQAPPLSATPS 877
            +       S HT LS        PSS     ++ H   P T +   +S+  +P  S T S
Sbjct: 393  TPVHSSTGSPHTTLS--------PSS-----STTHEGEPTTFQSWPSSKDTSPAPSGTTS 439

Query: 878  EYVVLSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSP--MNLS 935
             +V LS          +PSST  + FS        ++E   VH S      + P   + +
Sbjct: 440  AFVKLSTTY-----HSSPSSTPTTHFSASSTTLGHSEESTPVHSSPVATATTPPPARSAT 494

Query: 936  EEDQEDIGPFSPDSAFVSEFSFPPYATQEAEKRE---FECDSPICLTSPSEHTILSDEDT 992
                E+   +           FP  +T      E   F   +    +S    T      +
Sbjct: 495  SGHVEESTAYHRSPGSTQTMHFPESSTTSGHSEESATFHGSTTHTKSSTPSTTAALAHTS 554

Query: 993  EEAELFSPDSA--SQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTA 1050
              + L S ++      S    R  E++ +   PD++ T V  +G           +G + 
Sbjct: 555  YHSSLGSTETTHFRDSSTISGRSEESKASHSSPDAMATTVLPAG-----STPSVLVGDST 609

Query: 1051 ATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILA 1110
             +P+S                   +E  +LP ST K   +E                   
Sbjct: 610  PSPISS----------------GSMETTALPGSTTKPGLSE------------------- 634

Query: 1111 QKQKTQAYLEPESEDL--IPSHLTSEVEKGE------REASSSVAAIPAALP----AQSS 1158
              + T  Y  P S D   +P+ +TS     E      R  S+   A P +      +Q S
Sbjct: 635  --KSTTFYSSPRSPDTTHLPASMTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGLSQES 692

Query: 1159 IVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATA 1218
                 +   +  ++ P S  A     E T   +   + E           ++PD+  A+ 
Sbjct: 693  TASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTE---------TTLLPDNTTASG 743

Query: 1219 HVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEV 1278
                   +E   P    +   ++ L       ++G          S    +      P  
Sbjct: 744  ------LLEASMPVHSSTRSPHTTLSPAGSTTRQGES----TTFHSWPSSKDTRPAPPTT 793

Query: 1279 IKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSA---SSGVEKQVEHGPPALA 1335
               +     TS   P ++    +     ++ TT+ +V  S    SS    Q  H P +  
Sbjct: 794  TSAFVEPSTTSHGSPSSIPTTHI----SARSTTSGLVEESTTYHSSPGSTQTMHFPESDT 849

Query: 1336 FSALSEE-------IKKEIEPSSSTTTASV---TKLDSNLTRAVKEEIPTDSSLITPVDR 1385
             S   EE           I  + STT+A V   T   S+         P  S+     + 
Sbjct: 850  TSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEE 909

Query: 1386 PVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSE---AEKE 1442
               +   +   G+ + P  ++    SVL  E   +   +  +ET++   + +    +E+ 
Sbjct: 910  STASHSSQDATGTIVLPARSTT---SVLLGESTTSPISSGSMETTALPGSTTTPGLSERS 966

Query: 1443 IKFDSLP-------SVSSIAEHSVLSEVEAKEVKAG------LPVIKTSS--SQHSDKSE 1487
              F S P       S +S     V  E      + G       P   T+   S+HS  S 
Sbjct: 967  TTFHSSPRSPATTLSPASTTSSGVSEESTTSRSRPGSTHTTAFPDSTTTPGLSRHSTTSH 1026

Query: 1488 EARVEDKQDLL--FSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELP 1545
             +       LL   +T     +  ++   S  ST   L P     LS   E         
Sbjct: 1027 SSPGSTDTTLLPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQE--------S 1078

Query: 1546 SSQNVSPASKH--IIPKGKDEETASSSPELENL--ASGLAPTLLLLSDDKNKPAVEVSST 1601
            ++ + +P S H  + P   D  T+S   E      +S  +P   L       P ++  ST
Sbjct: 1079 TTFHSNPGSTHTTLFP---DSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGEST 1135

Query: 1602 AQGDFPSEKQDV----ALAELSLE--------PEKKDKPHQPLELPNAG-SEFSSDLGRQ 1648
            A    P+         + A   +E        P      H P     +G SE S+     
Sbjct: 1136 AFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSS 1195

Query: 1649 SGSIGTKQAKSPIT-----ETEDSVLEKGPAELRSREGKEENRELCASSTMPAISELSSL 1703
              + GT  + +  T     E+  S +  G  E+ +  G         S+T P +SE S+ 
Sbjct: 1196 PDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPG---------STTTPGLSEASTT 1246

Query: 1704 L--REESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADF 1761
                  S    + P S   + +  +   +    G       P + +  GLSEE +     
Sbjct: 1247 FYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSS 1306

Query: 1762 KKGGNQ-EIGPLPPTGNLKAQVMGDILDK-LSEETGHPNSSQVLQSITEPSKIAPSDLLV 1819
             +G  +  + P   T ++  +       +  S  T           +TE S   P     
Sbjct: 1307 SRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPAS 1366

Query: 1820 EQKKTEKALHS----DQTVKLPDVSTSSEDKQDLGIKQFS-LMRENLP--LEQSKSFMTT 1872
             Q      L +    +++   P  S S+  K        S L+ E+ P  L  S +  TT
Sbjct: 1367 TQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTT 1426

Query: 1873 KPADVKETKMEE----FFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQ 1928
             P       + E    F+ SP+  +  L      +S   +  + S     S+     P  
Sbjct: 1427 LPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDS 1486

Query: 1929 LKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLA 1988
               +  S++ T         HS++ S  ++    S   +S G   T    S    E  L 
Sbjct: 1487 TTTSDLSQEPTTS-------HSSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLL 1539

Query: 1989 EEPKSLVLAGNVERNIAEGKEIHSL-------MESESLLLEKANTELSWPSKEDSQEKIK 2041
              P   + +G VE +        SL         + + L E++ T  SWPS  D+     
Sbjct: 1540 --PDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPS-- 1595

Query: 2042 LPPERFFQKPVSGLSVEQVKSETI----SSSVKTAHFPAEGVEPALGNEKEAHRSTPP-- 2095
             PP         G +   V+  T      SS  T HF A         E     S+P   
Sbjct: 1596 -PP---------GTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPGAT 1645

Query: 2096 ----FPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEV 2151
                FP       S +V          G   +  +   T    +S        SP SP+ 
Sbjct: 1646 GTALFPTRS--ATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDT 1703

Query: 2152 TQNP 2155
            T +P
Sbjct: 1704 TLSP 1707



 Score = 42.4 bits (98), Expect = 0.010
 Identities = 131/633 (20%), Positives = 203/633 (32%), Gaps = 100/633 (15%)

Query: 1681 GKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLE-SKEPPASVAEGGNPE 1739
            G  E   L  S+T P +SE S+      ++ +       + S   S+E   S +  G+  
Sbjct: 616  GSMETTALPGSTTKPGLSEKSTTFYSSPRSPDTTHLPASMTSSGVSEESTTSHSRPGSTH 675

Query: 1740 EFQ-PFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPT---GNLKAQVMGDILDKLSEETG 1795
                P + ++ GLS+E +         +   GP   T   G+  A  +G          G
Sbjct: 676  TTAFPGSTTMPGLSQEST-------ASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPG 728

Query: 1796 HPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFS 1855
               ++ +      P     S LL        +  S  T   P  ST+ +           
Sbjct: 729  STETTLL------PDNTTASGLLEASMPVHSSTRSPHTTLSPAGSTTRQG---------- 772

Query: 1856 LMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQH-EQRIAGSV 1914
               E+       S   T+PA    T     F+ P   +   G P ++ + H   R   S 
Sbjct: 773  ---ESTTFHSWPSSKDTRPAPPTTTSA---FVEPSTTSH--GSPSSIPTTHISARSTTSG 824

Query: 1915 QLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVS-ALDTSSGNTE 1973
             ++ S++    PG  +     +  T   R +     +  SH S+   +S A  T+S   E
Sbjct: 825  LVEESTTYHSSPGSTQTMHFPESDTTSGRGE----ESTTSHSSTTHTISSAPSTTSALVE 880

Query: 1974 TLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAE-------GKEIHSLMESESLLLEKANT 2026
              +S   S         P S   +G  E + A        G  +     + S+LL ++ T
Sbjct: 881  EPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTT 940

Query: 2027 ELSWPSKEDSQEKIKLP--------PER---FFQKP-------------VSGLSVEQVKS 2062
                P    S E   LP         ER   F   P              SG+S E   S
Sbjct: 941  S---PISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPATTLSPASTTSSGVSEESTTS 997

Query: 2063 ETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKP 2122
             +   S  T  FP     P L        S+P   +   L  S           +     
Sbjct: 998  RSRPGSTHTTAFPDSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSG---PSQESTTSH 1054

Query: 2123 SPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKG-----KKGISS 2177
            S      T   P S+      Q  ES     NP +      PD     G      +  SS
Sbjct: 1055 SSSGSTDTALSPGSTTALSFGQ--ESTTFHSNPGSTHTTLFPDSTTSSGIVEASTRVHSS 1112

Query: 2178 FKSWMSSLFFGSSTPDNKVAEQEDLETQPSPS-------------VEKAVTVIDPEGTIP 2224
              S  ++L   SST      E    +T P+ +             VE++ T     G+ P
Sbjct: 1113 TGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTP 1172

Query: 2225 -TNFNVAEKPADHSLSEVKLKTADEPRGTLVKS 2256
             T+F  +   + HS       ++ +  GT   S
Sbjct: 1173 TTHFPASSTTSGHSEKSTIFHSSPDASGTTPSS 1205



 Score = 38.1 bits (87), Expect = 0.18
 Identities = 138/656 (21%), Positives = 210/656 (32%), Gaps = 109/656 (16%)

Query: 1518 STSEVLEPEHELPLSLWGEIKK--------KETELPSSQNVSPASK-----HIIPKGKDE 1564
            +T   L P H       GE K         + T LP S   +  S+     +  P+  D 
Sbjct: 233  ATGTTLFPSHSATSVFVGEPKTSPITSASMETTALPGSTTTAGLSEKSTTFYSSPRSPDR 292

Query: 1565 -----ETASSSPELENLASGLAPT---LLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALA 1616
                  T SS    ++  S   P     +   D    P V   STA    P    D  L+
Sbjct: 293  TLSPARTTSSGVSEKSTTSHSRPGPTHTIAFPDSTTMPGVSQESTASHSIPGST-DTTLS 351

Query: 1617 ELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPI-TETEDSVLEKGPAE 1675
              +  P     P       + G   ++ L   + + G  +A +P+ + T        P+ 
Sbjct: 352  PGTTTPSSLG-PESTTFHSSPGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPSS 410

Query: 1676 LRSREGKEENRELCASS--TMPAISELSSLLREES-----------------------QN 1710
              + EG+    +   SS  T PA S  +S   + S                        +
Sbjct: 411  STTHEGEPTTFQSWPSSKDTSPAPSGTTSAFVKLSTTYHSSPSSTPTTHFSASSTTLGHS 470

Query: 1711 EEIKPFSPKIISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIG 1770
            EE  P     ++  +  PPA  A  G+ EE   +  S  G ++ +  P      G+ E  
Sbjct: 471  EESTPVHSSPVATATTPPPARSATSGHVEESTAYHRS-PGSTQTMHFPESSTTSGHSEES 529

Query: 1771 PL--PPTGNLKAQVMGDILDKLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKAL 1828
                  T + K+          +    H +    L S TE +    S  +  + +  KA 
Sbjct: 530  ATFHGSTTHTKSST-----PSTTAALAHTSYHSSLGS-TETTHFRDSSTISGRSEESKAS 583

Query: 1829 HSD----QTVKLPDVSTSS---EDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKETK 1881
            HS      T  LP  ST S    D     I   S+    LP        TTKP      K
Sbjct: 584  HSSPDAMATTVLPAGSTPSVLVGDSTPSPISSGSMETTALP------GSTTKPG--LSEK 635

Query: 1882 MEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCE 1941
               F+ SP+  +          +     +  S   + S+++  RPG       S   T  
Sbjct: 636  STTFYSSPRSPD---------TTHLPASMTSSGVSEESTTSHSRPG-------STHTTAF 679

Query: 1942 VRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSS--KSYSSEEVKLAEEPKSLVLAGN 1999
                 +P  ++ES  S         T S  + T SS    Y++   +      +L+    
Sbjct: 680  PGSTTMPGLSQESTASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTETTLLPDNT 739

Query: 2000 VERNIAEGK-EIHSLMESESLLLEKA---------NTELSWPSKEDSQEKIKLPPERFFQ 2049
                + E    +HS   S    L  A          T  SWPS +D++     PP     
Sbjct: 740  TASGLLEASMPVHSSTRSPHTTLSPAGSTTRQGESTTFHSWPSSKDTR---PAPP----- 791

Query: 2050 KPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEES 2105
               S        S    SS+ T H  A      L  E   + S+P   +     ES
Sbjct: 792  TTTSAFVEPSTTSHGSPSSIPTTHISARSTTSGLVEESTTYHSSPGSTQTMHFPES 847



 Score = 32.7 bits (73), Expect = 7.5
 Identities = 41/177 (23%), Positives = 63/177 (35%), Gaps = 18/177 (10%)

Query: 1944 KQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERN 2003
            K  L  S    H S +  VS   +  G T T    S+S+  V + E   S + + ++E  
Sbjct: 209  KHFLDSSTNSGH-SEESTVS--HSGPGATGTTLFPSHSATSVFVGEPKTSPITSASMETT 265

Query: 2004 IAEGKE-----------IHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPV 2052
               G              +S   S    L  A T  S  S++ +    +  P      P 
Sbjct: 266  ALPGSTTTAGLSEKSTTFYSSPRSPDRTLSPARTTSSGVSEKSTTSHSRPGPTHTIAFPD 325

Query: 2053 S----GLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEES 2105
            S    G+S E   S +I  S  T   P      +LG E     S+P + +   L ++
Sbjct: 326  STTMPGVSQESTASHSIPGSTDTTLSPGTTTPSSLGPESTTFHSSPGYTKTTRLPDN 382


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 91.3 bits (225), Expect = 2e-17
 Identities = 420/2118 (19%), Positives = 701/2118 (33%), Gaps = 288/2118 (13%)

Query: 32   SEGEEDETAAESEEEPDSRLSDQDE---EGKIKQEYIISDPSFSMVTVQREDSGITWETN 88
            SE     T  E    P S  S+         +    ++S  + +  T   + +     ++
Sbjct: 546  SEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSS 605

Query: 89   SSRSSTPWASEESQTSGVCSREGSTVNSPPGNVSFIVDEVKKVRKRTHKSKHGSPSLRRK 148
             + SS+  A   S  +   S  G+T+ S   + + +          T    +   +   +
Sbjct: 606  EASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTE 665

Query: 149  GNRKRNSFESQDVPTNKKGSPLTSASQVLTTEKEKSYTGIYDKARKKKTT--SNTPPITG 206
                  + E   +PT    S  T  S  LT+    +      +A    TT    + P+T 
Sbjct: 666  ATSSSTTAEGTSMPT----STYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTT 721

Query: 207  AIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKDAS 266
            +      P       + T        ++  E   PL    ++P    + +      + ++
Sbjct: 722  STEASSSPTTADGASMPT--------STPSEGSTPLT---SMP----VSKTLLTSSEAST 766

Query: 267  ISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKI 326
            +S  P LD S   T S        + E     +  P  G+    S  +++      +   
Sbjct: 767  LSTTP-LDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEAST 825

Query: 327  YADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQSVPQQPEDEAKPHEVEPPSVTPDTP 386
             + +P+++ S +  +    SS   AE         S+P     E +      P  T    
Sbjct: 826  LSTTPVDSNSPVTTSTEVSSSPTPAE-------GTSMPTSTYSEGRTPLTSMPVSTTLVA 878

Query: 387  ATMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLEAASPGLAAS 446
             +     +    + ++P T ++E  SS + S                 S+  ++PG  ++
Sbjct: 879  TSAISTLSTTPVDTSTPVTNSTEARSSPTTS--------------EGTSMPTSTPGEGST 924

Query: 447  TQDGLDPDQEQPDLTSIER---AEPVSAKLTPTHPSVKGEKEENMLE----PSISLSE-- 497
                + PD   P ++S  R   A PV    TP   S +        E    P+ + SE  
Sbjct: 925  PLTSM-PDSTTPVVSSEARTLSATPVDTS-TPVTTSTEATSSPTTAEGTSIPTSTPSEGT 982

Query: 498  -PLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSEKPFPPHMSPEVE 556
             PL         +  S    ++  P DSN       E   P  P       P     E  
Sbjct: 983  TPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPP-PTAEGTSMPTSTPSEGS 1041

Query: 557  HKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQEGEPV 616
                 + +     +S E   LS    +    V+T S   S  S   D          E  
Sbjct: 1042 TPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQ-ASSSSTTADGTSMPTSTYSEGS 1100

Query: 617  PPSNVEAIAEHAVLSEEENEEFEAYSPAAAP---TSESSLSPSTTEKTS-------ENQS 666
             P     ++   V+S E +         + P   ++E+S SP+T E TS       E  +
Sbjct: 1101 TPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTT 1160

Query: 667  PLFSTVTPEYMVLSGDEASES----GCYTPDSTSASEYSVPSLATKESLKKTI--DRKSP 720
            PL S      +V+S +  + S       T  +TS    S P  A   S+  +   +R +P
Sbjct: 1161 PLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTP 1220

Query: 721  LILKGVSEYMIPSEEKEDTGSFTPA-----VAPASEPSLSPSTTEKTSECQSPLPSTATS 775
            L    V    + S E   T S +P      V  ++E S SP+T E TS     LP++ TS
Sbjct: 1221 LTSMPVRHTPVASSEAS-TLSTSPVDTSTPVTTSAETSSSPTTAEGTS-----LPTSTTS 1274

Query: 776  EHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKII---NEASQFKP--KGISEH 830
            E      G  L +      + + S  A+ L  T    K  +   NE S      +G S  
Sbjct: 1275 E------GSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMP 1328

Query: 831  TVLSVDGKEVIG--PSSPDLVVASEHSFPPHT--------TEMTSECQAP---------- 870
            T    +G+  +   P +  LV +S  S    T        T  T  C +P          
Sbjct: 1329 TSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPN 1388

Query: 871  -------------PLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYA----TPEA 913
                         P+S TP      S   A  ++  TP +TSA   S P  A     P +
Sbjct: 1389 SNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTS 1448

Query: 914  QEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPD-----SAFVSEFSFPPYATQEAEKR 968
               E      ++  +++P+  SE       P   +     S  VS    P   T  A   
Sbjct: 1449 TPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAIST 1508

Query: 969  EFECDSPICLTSPSEHTILSDE----DTEEAELFSP-DSASQVSIPPFRISETE---KNE 1020
              E  + +     S  T+ S E     T  A   +P  + SQ S  P     T       
Sbjct: 1509 PSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTY 1568

Query: 1021 LEPDSLLTAVSASGYSCFSE----ADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLE 1076
             E  + LT++  S     S          I S      S + SSS   +  +  + +P E
Sbjct: 1569 SEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSE 1628

Query: 1077 DLSLPPSTDKSEKAEIKPEIPTTSTSV--SEYLILAQKQKTQAYLEPESEDLIPS----- 1129
               L  S   S      PE  T ST+   S   ++   + + +    E   +  S     
Sbjct: 1629 GSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEG 1688

Query: 1130 --HLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKP-ASPHSVLPDSVPAIKKEQEP 1186
               LTS   +    ASS+++ +       S+ V   T+  +SP +    S+P     +  
Sbjct: 1689 RTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGT 1748

Query: 1187 TAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEP---QPPNVPESEMKYSVL 1243
            T   ++  +   +  S+       P         S +    P   +  ++P S +   + 
Sbjct: 1749 TPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMT 1808

Query: 1244 PDMVDEPKKGVKPKLVLN-VTSELEQRKLSKNEPEVIKPY-----SPLKETSLS------ 1291
            P +   P   V   LV N   S L    +  N P V         +P + TS++      
Sbjct: 1809 P-LTSTP---VSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSE 1864

Query: 1292 GPEALSAVKME-----MKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKE 1346
            G  AL+++ +          + ++TTP V  S       QV   P     S++     +E
Sbjct: 1865 GSTALTSIPVSTTTVASSETNTLSTTPAVT-STPVTTYAQVSSSPTTADGSSMPTSTPRE 1923

Query: 1347 IEP-----SSSTTTASVTKLDSNLTRAVKEEIPTD-----SSLITPVDRPVLTKVGKGEL 1396
              P       STTT + +++++  T       P       SS  T  D    T +     
Sbjct: 1924 GRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADG---TSMPTPAY 1980

Query: 1397 GSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPSVSSIAE 1456
              G  PL TS    + L    + +    +P++TS+     +E        S P+ +    
Sbjct: 1981 SEGSTPL-TSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEG------SSSPTTAGGTS 2033

Query: 1457 HSVLSEVEAKEVKAGLPVIKT-SSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSSQKKS 1515
                +  E     AG+PV  T   S   +      V+ K  +  ST   S         +
Sbjct: 2034 IQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMT 2093

Query: 1516 LMSTSEVLEPEHELPLSLWGEIKKKETEL---------PSSQNVSPASKHIIPKGKDEET 1566
            + + SE       +PLS       + + L         P   +   +S  I  +G   +T
Sbjct: 2094 ISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQT 2153

Query: 1567 ASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKD 1626
            ++ S     L S    T ++ S      A+   ST   D  +   +   A  S  P   +
Sbjct: 2154 STYSDRRTPLTSMPVSTTVVASS-----AISTLSTTPVDTSTPVTNSTEARSS--PTTSE 2206

Query: 1627 KPHQPLELPNAGSEFSSDLGRQSGSIGTKQA----------KSPITETEDSVLEKGPAEL 1676
                P   P+ GS   + +   +  + T +A           +P+T + ++      AE 
Sbjct: 2207 GTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEG 2266

Query: 1677 RS------REGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPA 1730
             S       EG      +  S T+ A SE+S+L         +   +P   S E+  PP 
Sbjct: 2267 TSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTL-----STTPVDSNTPFTTSTEASSPPP 2321

Query: 1731 SVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKL 1790
            +                    +E  S P      GN  +  +P +  + A      L   
Sbjct: 2322 T--------------------AEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTT 2361

Query: 1791 SEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLG 1850
              +T  P        +T  S+   S    +      + +S+ +  L  V  S+       
Sbjct: 2362 PADTSTP--------VTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPV---- 2409

Query: 1851 IKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFI--SPKDENW--MLGKPENVAS-- 1904
            +   +      P++ S    T+  A    T  E   I  SP  E    +   P +     
Sbjct: 2410 VSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVV 2469

Query: 1905 QHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSA 1964
              E     +  +D+S+     P       SS   T E     +  ++E S L +   VS 
Sbjct: 2470 SSEAGTLSTTPVDTST-----PMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVST 2524

Query: 1965 LDTSSGNTETLSSKSYSS 1982
               +S    TLS+    S
Sbjct: 2525 TPVASPEASTLSTTPVDS 2542



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 389/1959 (19%), Positives = 645/1959 (32%), Gaps = 366/1959 (18%)

Query: 380  SVTPDTPATMFLRTTKEECELASPGT--------AASENDSSVSPSFANEV----KKEDV 427
            SVT DTP     R T  E    S  T        +++E+ SS +     +V      E+ 
Sbjct: 97   SVTSDTPGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEES 156

Query: 428  YSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSVKGEKEEN 487
             S+  +    A  P   A T      D   P  TS +      A  +PT P       E+
Sbjct: 157  ISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQ------ASSSPTTP-------ES 203

Query: 488  MLEPSISLSE---PLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSE 544
               P  + SE   PL        ++ +S  I +   P +  +     +      SP  +E
Sbjct: 204  TTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVE--ISTPVTISAQASSSPTTAE 261

Query: 545  KPFPPHMSPEVEHKE-EELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQD 603
             P   + +P         + L ++   S E   LS         V T +   S  +  + 
Sbjct: 262  GPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEG 321

Query: 604  LNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAY--SPAAAPTSESSLSPSTTEKT 661
             +           P ++  A       SE           S     ++E S  P+T E T
Sbjct: 322  TSIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEAT 381

Query: 662  SENQSPLFSTVTP------EYMVLSGDEASESGCYTPDS----TSASE-YSVPSLATKES 710
            S   S L    TP        ++++  EAS +     DS    T+ASE  S P+ A   S
Sbjct: 382  SMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTS 441

Query: 711  LKKTI--DRKSPLILKGVSEYMIPSEEKEDTGSFTPA-----VAPASEPSLSPSTTEKTS 763
            +  +   +  +PL    VS   + S E  +  S TP      V  ++E S SP T E  S
Sbjct: 442  IATSTPSEGSTPLTSMPVSTTPVASSEASNL-STTPVDSKTQVTTSTEASSSPPTAEVNS 500

Query: 764  -----ECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINE 818
                   +   P T+ S   +P    +  +   TP        + P+  + E+       
Sbjct: 501  MPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDT-----STPVTTSSEA------S 549

Query: 819  ASQFKPKGISEHTVLSVDGKEVIG--PSSPDLVVASEHSFPPHT-----TEMTSECQAPP 871
            +S   P+G S  T    +G   +   P S  LVV+SE S    T     T +T+  +A  
Sbjct: 550  SSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASS 609

Query: 872  LSAT---PSEYVVLSDEEAVELERYTPSST-----SASEFSVPPY--ATPEAQEEEIVHR 921
             S T    S       E    +   + S+T      AS  S  P    TP     E    
Sbjct: 610  SSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSS 669

Query: 922  SLNLKGASSPMNLSEEDQEDIGPFSPDSAFVS------------EFSFPPYATQEAEKRE 969
            S   +G S P +   E    +     ++  V+            + S P   + EA    
Sbjct: 670  STTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSP 729

Query: 970  FECDSPICLTS-PSEHTILSDEDTEEAELFSPDSASQVSIPPFRIS-------------- 1014
               D     TS PSE +           L +   AS +S  P   S              
Sbjct: 730  TTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPT 789

Query: 1015 ETEKNEL------EPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAET 1068
             TE   +      E   LLT++  S     +     +  + + TPV      +   +  +
Sbjct: 790  TTEGTSMPISTPSEGSPLLTSIPVS----ITPVTSPEASTLSTTPVDSNSPVTTSTEVSS 845

Query: 1069 FPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIP 1128
             P  +P E  S+P ST    +       P TS  VS  L+      T +    ++     
Sbjct: 846  SP--TPAEGTSMPTSTYSEGRT------PLTSMPVSTTLVATSAISTLSTTPVDTS---- 893

Query: 1129 SHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDS-VPAIKKEQEPT 1187
            + +T+  E      +S   ++P + P + S         +P + +PDS  P +  E    
Sbjct: 894  TPVTNSTEARSSPTTSEGTSMPTSTPGEGS---------TPLTSMPDSTTPVVSSE---- 940

Query: 1188 AALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMV 1247
             A TL A       + V     V  S EAT+          +  ++P S           
Sbjct: 941  -ARTLSA-------TPVDTSTPVTTSTEATS-----SPTTAEGTSIPTS----------- 976

Query: 1248 DEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDS 1307
              P +G  P     +TS                  +P+  T ++  EA +     +  ++
Sbjct: 977  -TPSEGTTP-----LTS------------------TPVSHTLVANSEASTLSTTPVDSNT 1012

Query: 1308 KITTTPIVLHSASSGVEKQVEHGPPALAFSALSE-EIKKEIEPSSSTTTASVTKLDSNLT 1366
             +TT+        +     +    P+   + L+   +   +  SS T+T S T  D++  
Sbjct: 1013 PLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTP 1072

Query: 1367 RAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASP 1426
                 +  + S+       P  T         G  PL TS    + L    + +    +P
Sbjct: 1073 VTTYSQASSSSTTADGTSMPTST------YSEGSTPL-TSVPVSTRLVVSSEASTLSTTP 1125

Query: 1427 IETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKS 1486
            ++T                 S+P  +S    S  +  E   +    P   T+       S
Sbjct: 1126 VDT-----------------SIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVS 1168

Query: 1487 EEARVEDKQDLLFSTVCDSERLV--SSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETEL 1544
                V  + + L +T  DS+  V  S++  S   T+EV      +P S  GE     T +
Sbjct: 1169 TTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVT----SMPTSTPGERSTPLTSM 1224

Query: 1545 PSSQNVSPASKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQG 1604
            P         +H      +  T S+SP                  D + P          
Sbjct: 1225 P--------VRHTPVASSEASTLSTSPV-----------------DTSTPV--------- 1250

Query: 1605 DFPSEKQDVALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITET 1664
                       AE S  P   +    P    + GS   + +   +  + + +A + +T  
Sbjct: 1251 --------TTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTP 1302

Query: 1665 EDSVLEKGPA----ELRSREGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKI 1720
             D+   KGP     E+ S     E   +  S+     + L+S+           P +  +
Sbjct: 1303 VDT---KGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSI-----------PVNTTL 1348

Query: 1721 ISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKA 1780
            ++  +     S+      +   P T S +  S   +         N   G  P T     
Sbjct: 1349 VASSA----ISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLT----- 1399

Query: 1781 QVMGDILDKLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVS 1840
                         +   +++ V+ S        P D       + +A  S  T +   + 
Sbjct: 1400 -------------SIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIP 1446

Query: 1841 TSSEDKQDLGIKQFSLMRENLPLEQSK-SFMTTKPADVKETKMEEFFISPKDENWMLGKP 1899
            TS+  +    +K  S+   N P+  S+ S ++T P D     +    +S           
Sbjct: 1447 TSTPSEGKTPLK--SIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVS----------- 1493

Query: 1900 ENVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQ 1959
             +        IA S   + S++    P       SS     E+       +   + +++ 
Sbjct: 1494 SSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASS-----EINSLSTTPAVTSTPVTTY 1548

Query: 1960 EAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESL 2019
               S+  T++  T ++ + +YS     L   P S +L  + E N      I S  +    
Sbjct: 1549 SQASSSPTTADGT-SMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQ---- 1603

Query: 2020 LLEKANTEL-SWPSKEDSQEKIKLPPE---RFFQKPVSGLSVEQVKSETISSSVKTAHFP 2075
                A+TE  S  + E S   I  P E        PVS   V   ++ T+S++      P
Sbjct: 1604 --VTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTT------P 1655

Query: 2076 AEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPI 2135
             +   P +        ST       P E + M  S       EG+ P   + + T     
Sbjct: 1656 VDSNSPVI-------TSTEVSSSPTPAEGTSMPTSTY----TEGRTPLTSITVRTTPVAS 1704

Query: 2136 SSIH--AREPQSPESP-----EVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFG 2188
            S+I   +  P    +P     E   +P T    + P+    +G   ++S    +S+    
Sbjct: 1705 SAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIP--VSTTPVL 1762

Query: 2189 SSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGT-IPTN 2226
            SS      A   D  T  + S E   +    EGT IPT+
Sbjct: 1763 SSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTS 1801



 Score = 73.2 bits (178), Expect = 5e-12
 Identities = 327/1645 (19%), Positives = 560/1645 (34%), Gaps = 207/1645 (12%)

Query: 32   SEGEEDETAAESEEEPDSRLSDQDEE--GKIKQEYIISDPSFSMVTVQREDSGITWETNS 89
            +E     T AE    P S LS+             ++++   S ++    DS   + T++
Sbjct: 2255 TEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTST 2314

Query: 90   SRSSTPWASEESQTSGVCSREGST-VNSPPGNVSFIVDEVKKVRKRTHKSKHGSPSLRRK 148
              SS P  +E +      S EG+T +   P + + +          T        +   +
Sbjct: 2315 EASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQ 2374

Query: 149  GNRKRNSFESQDVPTNKKGSPLTSASQVLTTEKEKSYTGIYDKARKKKTT--SNTPPITG 206
                  + +   +PT    S  +  S  LT+    +   +  +A    TT    + P+T 
Sbjct: 2375 AGSSPTTADDTSMPT----STYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTT 2430

Query: 207  AIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKDAS 266
            +      P       I T        +   E   PL          V  E         +
Sbjct: 2431 STEASSSPTTAEGTSIPT--------SPPSEGTTPLASMPVSTTPVVSSEA-------GT 2475

Query: 267  ISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKI 326
            +S  P +D S   T S        + ED V  +     G+    S  ++       +   
Sbjct: 2476 LSTTP-VDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEAST 2534

Query: 327  YADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQ----SVPQQPED-EAKPHEVEPPSV 381
             + +P+++ S +  T    SSS  + +G  +  S     S P +      KP      S 
Sbjct: 2535 LSTTPVDSNSPVV-TSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEAST 2593

Query: 382  TPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLEAASP 441
               TP    +  T      +SP TA   +    +PS  +      + S     S EA++ 
Sbjct: 2594 LSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTL 2653

Query: 442  G---------LAASTQDGLDPDQEQ----PDLTSIERAEPVSAKL--------------- 473
                      +  ST     P   +    P  T  ER+ P++  L               
Sbjct: 2654 STTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLS 2713

Query: 474  -------TPTHPSVKGEKEENMLE-PSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSN 525
                   TP   S +        E  S+ +S P     P    + ++LP+A +    +++
Sbjct: 2714 TTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASS----EAS 2769

Query: 526  LVEEEIVELDYP--------ESPLVSEKPFPPHMSP-EVEHKEEELILPLLAASSPEHVA 576
             V    V+   P         SP  +E    P  +P E       + +     +S E   
Sbjct: 2770 TVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGT 2829

Query: 577  LSEEEREEIASVSTGSAFVSEYSVPQDLNHELQE-QEGEP----VPPSNVEAIAEHAVLS 631
            LS    +    V+T +   S  +  + +   +    EG      +P S     +  A  S
Sbjct: 2830 LSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEA--S 2887

Query: 632  EEENEEFEAYSPAAAPTSESSLSPSTTEKTSENQSPLFSTVTPEYMVL------SGDEAS 685
                   +   P    T E S SP+T E TS   S      TP   +L      +G EAS
Sbjct: 2888 TLSTTPVDTSIPVTTST-EGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEAS 2946

Query: 686  ESGCY-----TPDSTSASEYSVPSLATKESLKKTI--DRKSPLILKGVSEYMIPSEEKED 738
                      TP +TSA   S P+ A   S+  +   +R++PL    VS   + S E   
Sbjct: 2947 TLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEAS- 3005

Query: 739  TGSFTPA-----VAPASEPSLSPSTTEKT-------SECQSPLPS--TATSEHVVPSEGE 784
            T S TPA     V  ++E S SP+T E T       SE  +PL S   +T+   +P E  
Sbjct: 3006 TLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIP-EAS 3064

Query: 785  DLGSERFTPDSKLISKY------------AAPLNATQESQKKIINEASQFKPKGISEHTV 832
             L +     +S +++              + P++   E    +        P   S  + 
Sbjct: 3065 TLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAIST 3124

Query: 833  LSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELER 892
            LS      +  S+P       HS P  +   +     P   +TP  Y+ +S    V  E 
Sbjct: 3125 LSTTP---VDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSED 3181

Query: 893  YTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFV 952
             T S+T   + S P   + EA        S   +G S P +   E    +      +  V
Sbjct: 3182 STLSATPV-DTSTPVTTSTEATS------STTAEGTSIPTSTPSEGMTPLTSVPVSNTPV 3234

Query: 953  SEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSIPPFR 1012
            +       +T   +       S    +SP      S   +  +E  +P ++  VS     
Sbjct: 3235 ASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVA 3294

Query: 1013 ISETEKNELEPDSLLTAVS-----------ASGYSCFSEADEEDIGSTAATPVSEQFSSS 1061
             SET      P    T V+           A G S  +    E  GST  T +S  FS++
Sbjct: 3295 SSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSE--GSTPLTNMS--FSTT 3350

Query: 1062 QKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKP------EIPTTSTSVSEYLILAQKQKT 1115
                +E   L +   D S P +T  S +A + P       IPT+S S     + +    T
Sbjct: 3351 PVVSSEASTLSTTPVDTSTPVTT--STEASLSPTTAEGTSIPTSSPSEGTTPLASMPVST 3408

Query: 1116 QAYLEPESEDLIPSHLTSE--VEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVL 1173
               +  E   L  + + S   V      +SS   A   +LP  ++     ++ ++P S++
Sbjct: 3409 TPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTT-----SEGSTPLSIM 3463

Query: 1174 PDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNV 1233
            P S   +   +  T + T       +  S         +S   TA V+          + 
Sbjct: 3464 PLSTTPVASSEASTLSTTPVDTSTPVTTSS------PTNSSPTTAEVTSMPTSTAGEGST 3517

Query: 1234 PESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSGP 1293
            P + M  S  P  V   +        ++  + +     + + P  ++  +    T   G 
Sbjct: 3518 PLTNMPVSTTP--VASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGS 3575

Query: 1294 EALSAVKMEMKH----DSKITTTPIVLHSASSGVEKQVEHGPP-----ALAFSALSEEIK 1344
             +L+ + +   +    ++   +TP V  S       Q    P       L  S  SE   
Sbjct: 3576 SSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVST 3635

Query: 1345 KEIEPSSSTTTASVTKLDSNLTRAVKEEIP------TDSSLITP--VDRPVLTKVGKGEL 1396
                   STT+ ++++  +  T  V    P        SS +TP     P+ T   +G  
Sbjct: 3636 PLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTP-SEGST 3694

Query: 1397 GSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEA-EKEIKFDSLP-SVSSI 1454
                 P+ T+    S  +     ++  ++P+ TS++ ++ S   +      S+P  +S++
Sbjct: 3695 PLTTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTL 3754

Query: 1455 AEHSVLSEVEA----KEVKAGLPVIKTSSSQ---HSDKSEEARVEDKQDLLFSTVCDSER 1507
                ++S        +     +P + TS S        S    +E    +  ST  +   
Sbjct: 3755 GTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERST 3814

Query: 1508 LVSSQKKSLMSTSEVLEPEHELPLS 1532
            L+++    L+S   V+ P     LS
Sbjct: 3815 LLTT---VLISPISVMSPSEASTLS 3836



 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 246/1145 (21%), Positives = 382/1145 (33%), Gaps = 191/1145 (16%)

Query: 378  PPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLE 437
            P S TP T + +   +T    + ++P T ++E  SS + S    +           ++  
Sbjct: 3111 PVSTTPVTSSAISTLSTTP-VDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYM 3169

Query: 438  AASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSVKGEKEENMLEPSISLSE 497
              S  L  S++D           T ++ + PV+     T  +           PS  ++ 
Sbjct: 3170 PVSTMLVVSSEDST------LSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMT- 3222

Query: 498  PLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSEKPFPPHMSP-EVE 556
            PL         + +S    ++  P DSN       E     SP  +E    P  +P E  
Sbjct: 3223 PLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEAS--SSPPTAEGTSMPTSTPSEGS 3280

Query: 557  HKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQEGEPV 616
                 + +     +S E   LS    +    V+T S   S   +    +           
Sbjct: 3281 TPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGST 3340

Query: 617  PPSNVEAIAEHAVLSEEEN---EEFEAYSPAAAPTSESSLSPSTTEKTS-------ENQS 666
            P +N+       V SE         +  +P    T E+SLSP+T E TS       E  +
Sbjct: 3341 PLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTST-EASLSPTTAEGTSIPTSSPSEGTT 3399

Query: 667  PLFSTVTPEYMVLSGDEAS------ESGCYTPDSTSASEYSVPSLATKESL--KKTIDRK 718
            PL S       V+S +  +      +S      ST AS  S P++A   SL    T +  
Sbjct: 3400 PLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEAS--SSPTIAEGTSLPTSTTSEGS 3457

Query: 719  SPLILKGVSEYMIPSEEKEDTGSFTPA-----VAPASEPSLSPSTTEKTS-------ECQ 766
            +PL +  +S   + S E   T S TP      V  +S  + SP+T E TS       E  
Sbjct: 3458 TPLSIMPLSTTPVASSEAS-TLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGS 3516

Query: 767  SPLPSTATSEH-VVPSEGEDLG-----SERFTPDSKLISKYAAPLNATQ----------- 809
            +PL +   S   V  SE   L      S  F   S   S   A L  T            
Sbjct: 3517 TPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSS 3576

Query: 810  -------ESQKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLVVA-----SEHSFP 857
                    S     +EAS      +   T ++   +    P+ P+++       SE S P
Sbjct: 3577 SLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTP 3636

Query: 858  ----PHTTEMTSECQAPPLSATP---SEYVVLSDE--------EAVELERYTPS------ 896
                P +T   +  +A   S  P   S  V+ S +        E   +  +TPS      
Sbjct: 3637 LTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPL 3696

Query: 897  -----------STSASEFSVPPY--ATPEAQEEEIVHRSLNLKGA----SSPMNLSEEDQ 939
                       S+  S  S P    +TP     E +  S  L       S PM +S    
Sbjct: 3697 TTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGT 3756

Query: 940  EDIGPFSPDSAFVSEFSFPP----YATQEAEKREFECDSPICL---------TSPSEHTI 986
              +   +P + F  E S P     Y +           SP  L         T+    T+
Sbjct: 3757 TILVSTTPVTRF-PESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTL 3815

Query: 987  LSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDI 1046
            L+        + SP  AS +S PP   S           LLT+  A  +S  +E     I
Sbjct: 3816 LTTVLISPISVMSPSEASTLSTPPGDTS---------TPLLTSTKAGSFSIPAEVTTIRI 3866

Query: 1047 GSTA--ATPVSEQFSSSQKQKAETFPLMS-----PLE-DLSLPPSTDKSEKAEIKPEIPT 1098
              T+  +TP++    S+      +FP  S     PL+   +  PSTD +    I P   T
Sbjct: 3867 SITSERSTPLTTLLVST--TLPTSFPGASIASTPPLDTSTTFTPSTDTASTPTI-PVATT 3923

Query: 1099 TSTSV---------SEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAI 1149
             S SV         + ++       + A + P +   + + + +  E      SSS    
Sbjct: 3924 ISVSVITEGSTPGTTIFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSS---- 3979

Query: 1150 PAALPAQSSIVKEETKPASPHSV--------LPDSVPAIKKEQEPTAALTLKAADEQMAL 1201
              +     S  KE T PA   +            S P        T+A TL A       
Sbjct: 3980 --STTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTS 4037

Query: 1202 SKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLN 1261
            + V    + P S+ +         +   PP  P +   +S  P         V P+ V  
Sbjct: 4038 TSVTTRPVTPSSESSRPSTITSHTI---PPTFPPA---HSSTPPTTSASSTTVNPEAVTT 4091

Query: 1262 VTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTT-------PI 1314
            +T+  +    + + P V     P   T  S P +   V          TTT         
Sbjct: 4092 MTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPR--------TTTCFGDGCQNT 4143

Query: 1315 VLHSASSGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRA-VKEEI 1373
                 + G    ++   P L +  L EE+   I+     T ++  +L   +T     EE+
Sbjct: 4144 ASRCKNGGTWDGLKCQCPNLYYGELCEEVVSSIDIGPPETISAQMELTVTVTSVKFTEEL 4203

Query: 1374 PTDSS 1378
               SS
Sbjct: 4204 KNHSS 4208



 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 302/1650 (18%), Positives = 540/1650 (32%), Gaps = 262/1650 (15%)

Query: 811  SQKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAP 870
            SQ  ++N   Q     +S+H           G +S ++V             M   C   
Sbjct: 43   SQGDVLNRQCQ----QLSQHVRTGSAANTATGTTSTNVV----------EPRMYLSCSTN 88

Query: 871  PLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASS 930
            P   T  E  V SD   V   R TP+ +  +  S     T      E        +G   
Sbjct: 89   P-EMTSIESSVTSDTPGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDV 147

Query: 931  PMNLSEEDQEDIGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDE 990
            PM+   E+       S   AFVS    P +    +   + +  +P+  ++ +  +  + E
Sbjct: 148  PMSTPSEES-----ISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPE 202

Query: 991  DTEEAELFSPDSASQVSIPPFRISETEKNE-----LEPDSLLTAVSASGYSCFSEADEE- 1044
             T   +  + + ++ ++  P    +   +E       P  + T V+ S  +  S    E 
Sbjct: 203  STTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEG 262

Query: 1045 -----DIGSTAATPV------------SEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKS 1087
                    S  +TP+            SE  + S    A   P+++  E  S P + + +
Sbjct: 263  PSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGT 322

Query: 1088 E---KAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLI---------------PS 1129
                    +   P TST  S   +   +  T +    ++  L+                S
Sbjct: 323  SIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATS 382

Query: 1130 HLTSEVEKGERE----------ASSSVAAIPAALPAQS-SIVKEETKPASPHSVLPDSVP 1178
             LTS + +G              +SS A+  + +P  S + V   ++ +S  +   D+  
Sbjct: 383  MLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSI 442

Query: 1179 AIKKEQEPTAALT---------LKAADEQMALSKVRKEEIVPDSQEA-----TAHVSQDQ 1224
            A     E +  LT           +    ++ + V  +  V  S EA     TA V+   
Sbjct: 443  ATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMP 502

Query: 1225 KMEPQPPNVPESEMKYSVLPDMVDEPKK-GVKPKLVLNVTSELEQRKLSKNEPEVIK-PY 1282
               P   + P + M  S +P    E       P       +   +   S   PE    P 
Sbjct: 503  TSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPT 562

Query: 1283 SPLKETSLSGPEALSAVKMEMKHDSKIT-TTP-----IVLHSASSGVEKQVEHGP--PAL 1334
            S   E S        + ++ +  ++  T TTP      V  S+ +        G   P  
Sbjct: 563  STPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTS 622

Query: 1335 AFS-----ALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLT 1389
             +S       S  +   +  SS  +T S T +DSN       E  + S+       P  T
Sbjct: 623  TYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTST 682

Query: 1390 KVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLP 1449
                     G  PL TS   ++ L    + +    +P++TS+     +EA       S P
Sbjct: 683  YT------EGSTPL-TSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEA------SSSP 729

Query: 1450 SVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLV 1509
            + +  A     +  E       +PV KT  +     S EA       L  ST   +    
Sbjct: 730  TTADGASMPTSTPSEGSTPLTSMPVSKTLLT-----SSEASTLSTTPLDTSTHITTSTEA 784

Query: 1510 SSQKKSLMSTSEVLEPEHE-------LPLSLWGEIKKKETEL---------PSSQNVSPA 1553
            S    +   TS  +    E       +P+S+      + + L         P + +   +
Sbjct: 785  SCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVS 844

Query: 1554 SKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDV 1613
            S     +G    T++ S     L S    T L+ +      A+   ST   D  +   + 
Sbjct: 845  SSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATS-----AISTLSTTPVDTSTPVTNS 899

Query: 1614 ALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAK----------SPITE 1663
              A  S  P   +    P   P  GS   + +   +  + + +A+          +P+T 
Sbjct: 900  TEARSS--PTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTT 957

Query: 1664 TEDSVLEKGPAELRS------REGKEENRELCASSTMPAISELSSLLREESQNEEIKPFS 1717
            + ++      AE  S       EG         S T+ A SE S+L         +   +
Sbjct: 958  STEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTL-----STTPVDSNT 1012

Query: 1718 PKIISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGN 1777
            P   S E+  PP +                    +E  S P      G+  +  +P +  
Sbjct: 1013 PLTTSTEASSPPPT--------------------AEGTSMPTSTPSEGSTPLTRMPVSTT 1052

Query: 1778 LKAQVMGDILDKLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLP 1837
            + A      L     +T  P        +T  S+ + S    +      + +S+ +  L 
Sbjct: 1053 MVASSETSTLSTTPADTSTP--------VTTYSQASSSSTTADGTSMPTSTYSEGSTPLT 1104

Query: 1838 DVSTSSEDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFI--SPKDENW- 1894
             V  S+     L +   +      P++ S    T+  A    T  E   I  SP  E   
Sbjct: 1105 SVPVSTR----LVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTT 1160

Query: 1895 ---MLGKPENVASQHEQRIAGSVQLDS----SSSNELRPGQLKAAVSSK------DHTCE 1941
                +     +    E     +  +DS    ++S E       A V+S       + +  
Sbjct: 1161 PLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTP 1220

Query: 1942 VRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGN-V 2000
            +    + H+   S  +S  + S +DTS+  T T +  S S    +    P S    G+ +
Sbjct: 1221 LTSMPVRHTPVASSEASTLSTSPVDTSTPVT-TSAETSSSPTTAEGTSLPTSTTSEGSTL 1279

Query: 2001 ERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQV 2060
              +I     + +  E+ +LL    +T+   P    ++      P      P S  S  + 
Sbjct: 1280 LTSIPVSTTLVTSPEASTLLTTPVDTK--GPVVTSNEVSSSPTPAEGTSMPTSTYS--EG 1335

Query: 2061 KSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGK 2120
            ++   S  V T    +  +  ++ +      STP     +        +   + +++  +
Sbjct: 1336 RTPLTSIPVNTTLVASSAI--SILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSE 1393

Query: 2121 KPSPEVKIPTQRKPISSIHAR-------EPQSP--ESPEVTQNPPTQPKVAKPDLPEEKG 2171
              +P   IP    P+ S  A        +  +P   S E T +P T   ++ P     +G
Sbjct: 1394 GTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEG 1453

Query: 2172 KKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAE 2231
            K  + S           S+TP    +E   L T P          +D    + T+  V+ 
Sbjct: 1454 KTPLKSIPV--------SNTPVAN-SEASTLSTTP----------VDSNSPVVTSTAVSS 1494

Query: 2232 KPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSREDYGK 2291
             P     + + + T  E    L        V   ++  S +  L     ++      Y +
Sbjct: 1495 SPTPAEGTSIAISTPSEGSTALTSI----PVSTTTVASSEINSLSTTPAVTSTPVTTYSQ 1550

Query: 2292 KEISGDSEEMNINSVVTSADGENLEIQSYS 2321
                        +S  T+ADG +++  +YS
Sbjct: 1551 -----------ASSSPTTADGTSMQTSTYS 1569



 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 138/596 (23%), Positives = 202/596 (33%), Gaps = 65/596 (10%)

Query: 367  PEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKED 426
            P D + P     P+ +  T A +    T    E ++P T    + + V+ S A+ +    
Sbjct: 3482 PVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTP 3541

Query: 427  VYSAHHSISLEAASPG---LAASTQDGLDPDQEQPDLTSIERAEPV---SAKLTPTHPSV 480
            V S     S   AS     L  +T     P +    LT++  +      S   TP+ PSV
Sbjct: 3542 VDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSV 3601

Query: 481  -KGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYP-- 537
             +        + + + + P ++  P     E S P+ I P    S  + E       P  
Sbjct: 3602 DRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVD 3661

Query: 538  ------ESPLVSEKPFPPHMSPEVEHKEEELILPLLAAS-SPEHVALSEEEREEIASVST 590
                   S  VS  P  P  +        E   PL     S   V  SE       SV T
Sbjct: 3662 TSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPSVVT 3721

Query: 591  GSAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPT-- 648
             +   +        +  L         P  +  +    ++S      F   S  + P+  
Sbjct: 3722 STPVTTSTEAISS-SATLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPESSTPSIPSVY 3780

Query: 649  --------SESSLSPSTTE--------KTSENQSPLFSTVTPEYMVLSGDEASESGCYTP 692
                    SE S SP+T E         TSE  + L + +     V+S  EAS       
Sbjct: 3781 TSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPG 3840

Query: 693  D-------STSASEYSVPSLATKESLKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPA 745
            D       ST A  +S+P+  T   +  T +R +PL    VS  +  S          P 
Sbjct: 3841 DTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTS---------FPG 3891

Query: 746  VAPASEPSLSPST--TEKTSECQSP-LPSTATSEHVVPSEGEDLGSERFTPDSKLISKYA 802
             + AS P L  ST  T  T    +P +P   T    V +EG   G+  F P + + S  A
Sbjct: 3892 ASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTA 3951

Query: 803  APLNATQES-QKKIINEASQFKPKGISEHTVLSVD-GKEVIGPSSP-----DLVVASEHS 855
                AT  +    +I       P   S  T  S    KE   P+         V  S   
Sbjct: 3952 DVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAP 4011

Query: 856  FPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYATP 911
              P TT       A  LSAT + +   S    V     TPSS S+   ++  +  P
Sbjct: 4012 STPRTTSRGCTTSASTLSATSTPHTSTS----VTTRPVTPSSESSRPSTITSHTIP 4063



 Score = 62.8 bits (151), Expect = 7e-09
 Identities = 321/1604 (20%), Positives = 547/1604 (34%), Gaps = 182/1604 (11%)

Query: 90   SRSSTPWASEESQTSGVCSREGSTVNSPPGNVSFIVDEVKKVRKRTHKSKHGSPSLRRKG 149
            S  +TP A     T+ V S EG+T+++ P      VD   +V   T  S     S   +G
Sbjct: 2040 SERTTPLAGMPVSTTLVVSSEGNTLSTTP------VDSKTQVTNSTEASS----SATAEG 2089

Query: 150  NRKRNSFESQDVPTNKKGSPLTSASQVLTTEKEKSYTGIYDKARKKKTT---SNTPPITG 206
            +       S  +    +GSPL ++  + TT           +A    TT   SN+P IT 
Sbjct: 2090 S-------SMTISAPSEGSPLLTSIPLSTTPVASP------EASTLSTTPVDSNSPVITS 2136

Query: 207  AIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKDAS 266
                        P+       +   ++  +  L  +    T+     I          ++
Sbjct: 2137 TEVSSS------PIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAI----------ST 2180

Query: 267  ISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKI 326
            +S  P +D S   T S   +    + E        P  G+    S  ++ M     +   
Sbjct: 2181 LSTTP-VDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEAST 2239

Query: 327  YADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQ---------SVPQQPEDEAKPHEVE 377
             + +P++ ++ +  +  + SS   AE G  +  S          S+P      A   EV 
Sbjct: 2240 LSATPVDTSTPVTTSTEATSSPTTAE-GTSIPTSTLSEGTTPLTSIPVSHTLVANS-EVS 2297

Query: 378  PPSVTPDTPATMFLRTTKEECELASP---GTAASENDSSVSPSFANEVKKEDVYSAHHSI 434
              S TP    T F  TT  E     P   GT+   + SS   +    +       A    
Sbjct: 2298 TLSTTPVDSNTPF--TTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFET 2355

Query: 435  SLEAASPG-----LAASTQDGLDP----DQEQPDLTSIERAEPVSAKLTPTHPSVKGEKE 485
            S  + +P      +   +Q G  P    D   P  T  E + P+++    T P V  E  
Sbjct: 2356 STLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSEAS 2415

Query: 486  ENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSEK 545
             +   P +  S P+           T+   +I   P         +  +    +P+VS +
Sbjct: 2416 THSTTP-VDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTP--LASMPVSTTPVVSSE 2472

Query: 546  PFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLN 605
                  +P        +     A+SSP     +E+    I++ S GS  ++  S+P    
Sbjct: 2473 AGTLSTTPV--DTSTPMTTSTEASSSP---TTAEDIVVPISTASEGSTLLT--SIPVSTT 2525

Query: 606  HELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEKTSENQ 665
              +   E   +  + V++ +   V S E +    +    + PTS  S   +       + 
Sbjct: 2526 -PVASPEASTLSTTPVDSNSP-VVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVST 2583

Query: 666  SPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSPLILKG 725
             PL S+   E   LS      S    P +TS    S P+ A   S+  +   +    L  
Sbjct: 2584 KPLASS---EASTLSTTPVDTS---IPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTS 2637

Query: 726  VSEYMIPSEEKE-DTGSFTPA-----VAPASEPSLSPSTTEKTSECQSPLPSTATSEHVV 779
            +    +P    E  T S TP      V  ++  S SP+T E +S     +P++   E   
Sbjct: 2638 ILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSS-----MPTSTPGERST 2692

Query: 780  PSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKE 839
            P     L S     +S+  +    P++ +          +S    +G S       DG  
Sbjct: 2693 PLTNI-LVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGST 2751

Query: 840  VIGPSSPD-LVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERYTPSST 898
             +       L VAS  +    TT + +     P++ +       +  E   +   TPS T
Sbjct: 2752 PLTSILVSTLPVASSEASTVSTTAVDTSI---PVTTSTEASSSPTTAEVTSMPTSTPSET 2808

Query: 899  SASEFSVPPYATPEAQEE----------EIVHRSLNLKGASSPMNLSEEDQEDIGPFSPD 948
            S    S+P   TP A  E               + + K +SSP   +E     I   S  
Sbjct: 2809 STPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSP-TTAEGIVVPISTASEG 2867

Query: 949  SAFVSEF--SFPPYATQEAEK-REFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQ 1005
            S  ++    S  P A+ EA        D+ I +T+ +E +  S   T E       + S+
Sbjct: 2868 STLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGS--SSPTTAEGTSMPISTPSE 2925

Query: 1006 VSIP---------PFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATP--- 1053
            VS P         P   SE       P    T V+ S  +  S    E      +TP   
Sbjct: 2926 VSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGER 2985

Query: 1054 ----VSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPE------IPTTSTSV 1103
                 S   S+     +E   L     D S P +T  S +A   P       IP ++ S 
Sbjct: 2986 RTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTT--STEASSSPTTAEGTGIPISTPSE 3043

Query: 1104 SEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEE 1163
                + +    T     PE+  L  + + S         S+ V++ P      S  +   
Sbjct: 3044 GSTPLTSIPVSTTPVAIPEASTLSTTPVDS---NSPVVTSTEVSSSPTPAEGTSMPISTY 3100

Query: 1164 TKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQD 1223
            ++ ++P + +P S   +      T + T    D    ++   +    P + E T+     
Sbjct: 3101 SEGSTPLTGVPVSTTPVTSSAISTLSTT--PVDTSTPVTTSTEAHSSPTTSEGTS----- 3153

Query: 1224 QKMEPQPPNVPESEMKYSVLPDMV-----DEPKKGVKPKLVLNVTSELEQRKLSKNEPEV 1278
              M    P+   + + Y  +  M+     D             VT+  E    +  E   
Sbjct: 3154 --MPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTS 3211

Query: 1279 IKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSA 1338
            I   +P +  +      +S   +     S ++TTP+  ++  +    +    PP    ++
Sbjct: 3212 IPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLT-TSTEASSSPPTAEGTS 3270

Query: 1339 LSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGS 1398
            +         PS  +T   +T +  + T     E  T S+  TP D    T V      S
Sbjct: 3271 MPTS-----TPSEGST--PLTSMPVSTTTVASSETSTLST--TPAD--TSTPVTTYSQAS 3319

Query: 1399 GLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAE--KEIKFDSLPSVSSIAE 1456
              PP+       +    E    +   S    S+  +  SEA        D+   V++  E
Sbjct: 3320 SSPPIADGTSMPTSTYSEGSTPLTNMS---FSTTPVVSSEASTLSTTPVDTSTPVTTSTE 3376

Query: 1457 HSVL-SEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSSQKKS 1515
             S+  +  E   +    P   T+       S    V  + + L +T  DS  LV++  ++
Sbjct: 3377 ASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEA 3436

Query: 1516 LMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSSPELEN 1575
              S+S  +     LP S   E     + +P S   +P +             +S+P   +
Sbjct: 3437 --SSSPTIAEGTSLPTSTTSEGSTPLSIMPLS--TTPVASSEASTLSTTPVDTSTPVTTS 3492

Query: 1576 LASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELS 1619
              +  +PT   ++      A E  ST   + P     VA +E S
Sbjct: 3493 SPTNSSPTTAEVTSMPTSTAGE-GSTPLTNMPVSTTPVASSEAS 3535


>gi|148833499 midline 1 [Homo sapiens]
          Length = 667

 Score = 89.7 bits (221), Expect = 5e-17
 Identities = 121/584 (20%), Positives = 216/584 (36%), Gaps = 124/584 (21%)

Query: 3503 ELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLR 3562
            E +  +++ YC T    I A  K+ G H+DH+V+ L                        
Sbjct: 177  EHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSER--------------------- 215

Query: 3563 IEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLH 3622
                       ++ +++N   N   L ++N E+ + +LA+  +  Q  E    ++   L 
Sbjct: 216  -----------YDKLKQNLESNLTNLIKRNTEL-ETLLAKLIQTCQHVEVNASRQEAKLT 263

Query: 3623 EQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAF 3682
            E+    ++ +   +  + T ++E + +          ++ +++ +  +    +E+  +  
Sbjct: 264  EECDLLIEIIQQRRQIIGTKIKEGKVM-------RLRKLAQQIANCKQC---IERSASLI 313

Query: 3683 SLFEHY--DDSSARSDQMLKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQV 3740
            S  EH   ++  AR  Q  K +          +  + AT+++  +   +N  D  D+F +
Sbjct: 314  SQAEHSLKENDHARFLQTAKNIT---------ERVSMATASSQVLIPEINLNDTFDTFAL 364

Query: 3741 YCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIF 3800
                E +                     + E L+                         +
Sbjct: 365  DFSREKK---------------------LLECLD-------------------------Y 378

Query: 3801 RTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEY--------CRQHSPEGEGLR 3852
             TAP+ P IR E CT  ++T T+ W      +  +Y L+Y                +   
Sbjct: 379  LTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWM 438

Query: 3853 SFSGIKGLQLKVN-LQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPAL 3911
                IK     V+ LQ    Y F V+AIN  G S  SE   + T    F L  ++AH  L
Sbjct: 439  IVPNIKQNHYTVHGLQSGTKYIFMVKAINQAG-SRSSEPGKLKTNSQPFKLDPKSAHRKL 497

Query: 3912 HISSSGTVISFGER--------RRLTEIPS--VLGEELPSCGQHYWETTVTDCPAYRLGI 3961
             +S     +   E          R T   S  V G      G+HYWE  ++    Y +G+
Sbjct: 498  KVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGL 557

Query: 3962 CSSSAVQAGALGQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRLI 4021
               SA +   +G+   SW + C     +   ++     +       RVGILLDY+N  + 
Sbjct: 558  AYKSAPKHEWIGKNSASWAL-CRCNNNWVVRHNSKEIPIEPAPHLRRVGILLDYDNGSIA 616

Query: 4022 FINAESEQLLFIIRHRFNEGVHPAFALEKPGKC-TLHLGIEPPD 4064
            F +A +   L+     F + V P F +    KC T+  G+  PD
Sbjct: 617  FYDALNSIHLYTFDVAFAQPVCPTFTVW--NKCLTIITGLPIPD 658


>gi|4557753 midline 1 [Homo sapiens]
          Length = 667

 Score = 89.7 bits (221), Expect = 5e-17
 Identities = 121/584 (20%), Positives = 216/584 (36%), Gaps = 124/584 (21%)

Query: 3503 ELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLR 3562
            E +  +++ YC T    I A  K+ G H+DH+V+ L                        
Sbjct: 177  EHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSER--------------------- 215

Query: 3563 IEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLH 3622
                       ++ +++N   N   L ++N E+ + +LA+  +  Q  E    ++   L 
Sbjct: 216  -----------YDKLKQNLESNLTNLIKRNTEL-ETLLAKLIQTCQHVEVNASRQEAKLT 263

Query: 3623 EQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAF 3682
            E+    ++ +   +  + T ++E + +          ++ +++ +  +    +E+  +  
Sbjct: 264  EECDLLIEIIQQRRQIIGTKIKEGKVM-------RLRKLAQQIANCKQC---IERSASLI 313

Query: 3683 SLFEHY--DDSSARSDQMLKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQV 3740
            S  EH   ++  AR  Q  K +          +  + AT+++  +   +N  D  D+F +
Sbjct: 314  SQAEHSLKENDHARFLQTAKNIT---------ERVSMATASSQVLIPEINLNDTFDTFAL 364

Query: 3741 YCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIF 3800
                E +                     + E L+                         +
Sbjct: 365  DFSREKK---------------------LLECLD-------------------------Y 378

Query: 3801 RTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEY--------CRQHSPEGEGLR 3852
             TAP+ P IR E CT  ++T T+ W      +  +Y L+Y                +   
Sbjct: 379  LTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWM 438

Query: 3853 SFSGIKGLQLKVN-LQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPAL 3911
                IK     V+ LQ    Y F V+AIN  G S  SE   + T    F L  ++AH  L
Sbjct: 439  IVPNIKQNHYTVHGLQSGTKYIFMVKAINQAG-SRSSEPGKLKTNSQPFKLDPKSAHRKL 497

Query: 3912 HISSSGTVISFGER--------RRLTEIPS--VLGEELPSCGQHYWETTVTDCPAYRLGI 3961
             +S     +   E          R T   S  V G      G+HYWE  ++    Y +G+
Sbjct: 498  KVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGL 557

Query: 3962 CSSSAVQAGALGQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRLI 4021
               SA +   +G+   SW + C     +   ++     +       RVGILLDY+N  + 
Sbjct: 558  AYKSAPKHEWIGKNSASWAL-CRCNNNWVVRHNSKEIPIEPAPHLRRVGILLDYDNGSIA 616

Query: 4022 FINAESEQLLFIIRHRFNEGVHPAFALEKPGKC-TLHLGIEPPD 4064
            F +A +   L+     F + V P F +    KC T+  G+  PD
Sbjct: 617  FYDALNSIHLYTFDVAFAQPVCPTFTVW--NKCLTIITGLPIPD 658


>gi|15451852 midline 1 [Homo sapiens]
          Length = 667

 Score = 89.7 bits (221), Expect = 5e-17
 Identities = 121/584 (20%), Positives = 216/584 (36%), Gaps = 124/584 (21%)

Query: 3503 ELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLR 3562
            E +  +++ YC T    I A  K+ G H+DH+V+ L                        
Sbjct: 177  EHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSER--------------------- 215

Query: 3563 IEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLH 3622
                       ++ +++N   N   L ++N E+ + +LA+  +  Q  E    ++   L 
Sbjct: 216  -----------YDKLKQNLESNLTNLIKRNTEL-ETLLAKLIQTCQHVEVNASRQEAKLT 263

Query: 3623 EQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAF 3682
            E+    ++ +   +  + T ++E + +          ++ +++ +  +    +E+  +  
Sbjct: 264  EECDLLIEIIQQRRQIIGTKIKEGKVM-------RLRKLAQQIANCKQC---IERSASLI 313

Query: 3683 SLFEHY--DDSSARSDQMLKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQV 3740
            S  EH   ++  AR  Q  K +          +  + AT+++  +   +N  D  D+F +
Sbjct: 314  SQAEHSLKENDHARFLQTAKNIT---------ERVSMATASSQVLIPEINLNDTFDTFAL 364

Query: 3741 YCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIF 3800
                E +                     + E L+                         +
Sbjct: 365  DFSREKK---------------------LLECLD-------------------------Y 378

Query: 3801 RTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEY--------CRQHSPEGEGLR 3852
             TAP+ P IR E CT  ++T T+ W      +  +Y L+Y                +   
Sbjct: 379  LTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWM 438

Query: 3853 SFSGIKGLQLKVN-LQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPAL 3911
                IK     V+ LQ    Y F V+AIN  G S  SE   + T    F L  ++AH  L
Sbjct: 439  IVPNIKQNHYTVHGLQSGTKYIFMVKAINQAG-SRSSEPGKLKTNSQPFKLDPKSAHRKL 497

Query: 3912 HISSSGTVISFGER--------RRLTEIPS--VLGEELPSCGQHYWETTVTDCPAYRLGI 3961
             +S     +   E          R T   S  V G      G+HYWE  ++    Y +G+
Sbjct: 498  KVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGL 557

Query: 3962 CSSSAVQAGALGQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRLI 4021
               SA +   +G+   SW + C     +   ++     +       RVGILLDY+N  + 
Sbjct: 558  AYKSAPKHEWIGKNSASWAL-CRCNNNWVVRHNSKEIPIEPAPHLRRVGILLDYDNGSIA 616

Query: 4022 FINAESEQLLFIIRHRFNEGVHPAFALEKPGKC-TLHLGIEPPD 4064
            F +A +   L+     F + V P F +    KC T+  G+  PD
Sbjct: 617  FYDALNSIHLYTFDVAFAQPVCPTFTVW--NKCLTIITGLPIPD 658


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 88.6 bits (218), Expect = 1e-16
 Identities = 445/2273 (19%), Positives = 793/2273 (34%), Gaps = 408/2273 (17%)

Query: 983  EHTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDS--LLTAVSASGYSCFSE 1040
            E  I+SDE+ EEA   +P   ++      RI +  K ++E DS  L+  ++    +C   
Sbjct: 1591 EWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPL 1650

Query: 1041 ADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTS 1100
              E+          + Q  + +K +A      S  E   +PP   +S + + KP +    
Sbjct: 1651 PKEQ--------LQTVQDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPSL-GIK 1701

Query: 1101 TSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREAS--SSVAAIPAALP---A 1155
              V   L   QKQK         E L  S   +E++KG  E S        P  LP   A
Sbjct: 1702 KPVRRKLKEKQKQK--------EEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPTVKA 1753

Query: 1156 QSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSK----VRKEEIVP 1211
             S +++E     +P   + D V A++K  E          DEQ   SK    V+ +E VP
Sbjct: 1754 TSPLIEE-----TPIGSIKDKVKALQKRVE----------DEQKGRSKLPIRVKGKEDVP 1798

Query: 1212 DSQEATAH--VSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQR 1269
                   H   S   K E   P  P               PK      L  +  +E    
Sbjct: 1799 KKTTHRPHPAASPSLKSERHAPGSP--------------SPKTERHSTLSSSAKTERHPP 1844

Query: 1270 KLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEH 1329
                ++ E   P SP  +T    P A S+ K E KH     +T    HS  S    + E 
Sbjct: 1845 VSPSSKTEKHSPVSPSAKTERHSP-ASSSSKTE-KHSPVSPSTKTERHSPVSST--KTER 1900

Query: 1330 GPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLT 1389
             PP     + S +  K    S S  T     +    T   ++ +P   S  T   +PV T
Sbjct: 1901 HPPV----SPSGKTDKRPPVSPSGRTEKHPPVSPGRT---EKRLPVSPSGRTDKHQPVST 1953

Query: 1390 KVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLP 1449
                G+    LP                       SP   + K    S   K  + +   
Sbjct: 1954 ---AGKTEKHLP----------------------VSPSGKTEKQPPVSPTSKTERIEETM 1988

Query: 1450 SVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLV 1509
            SV  + + +  S  +  + K GL   K++  +   +  + RVE ++  +           
Sbjct: 1989 SVRELMK-AFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPIL---------- 2037

Query: 1510 SSQKKSLMSTSEVLEPEHELPLSLWGEIKK--KETELPSSQNVSPASKHIIPKGKDEETA 1567
             +Q+++  + ++ ++    LP++   E K+  + + +   +  +   K  +   K  E  
Sbjct: 2038 -TQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPV 2096

Query: 1568 SSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKDK 1627
             S PE E+      P        K K A E     QGD           +L + P++K  
Sbjct: 2097 QSVPEEESHRESEVP--------KEKMADE-----QGDM----------DLQISPDRK-- 2131

Query: 1628 PHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRE 1687
                       ++FS  + ++       Q      ETE + L      L S        +
Sbjct: 2132 ---------TSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQV-LTSPFNTTFPLD 2181

Query: 1688 LCASSTMPAISELSSLL---REESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQPF 1744
                  +PA+S  S  L    E  +NE +           +  P  S+ E G P+     
Sbjct: 2182 YMKDEFLPALSLQSGALDGSSESLKNEGV-----------AGSPCGSLME-GTPQISSEE 2229

Query: 1745 TFSLKGLSE--EVS-HPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNSSQ 1801
            ++  +GL+E  E S     F    ++E      TG  K     +   ++  E  HP +  
Sbjct: 2230 SYKHEGLAETPETSPESLSFSPKKSEE-----QTGETKESTKTETTTEIRSEKEHPTTKD 2284

Query: 1802 VL-------QSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSS-----EDKQDL 1849
            +         ++TE S+ +       QK+       D + K  D  T S       +   
Sbjct: 2285 ITGGSEERGATVTEDSETSTESF---QKEATLGSPKDTSPKRQDDCTGSCSVALAKETPT 2341

Query: 1850 GIKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQR 1909
            G+ + +   E      S +  T   ++V+E+       +  DE   L  PE         
Sbjct: 2342 GLTEEAACDEGQRTFGSSAHKTQTDSEVQES------TATSDETKALPLPE--------- 2386

Query: 1910 IAGSVQLDSSSSNELR-----PGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSA 1964
               SV+ D+ + ++ +     P  L+ A+ S+D   EV   V   S   SH  S EA   
Sbjct: 2387 --ASVKTDTGTESKPQGVIRSPQGLELALPSRD--SEVLSAVADDSLAVSHKDSLEASPV 2442

Query: 1965 LDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGK-EIHSLMESESLLLEK 2023
            L+ +S +    S +    +E    +  +S  +   ++  I      + + +    LL E 
Sbjct: 2443 LEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEV 2502

Query: 2024 ANT------ELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAE 2077
            A+       +    +++DS E+  L          S LS +   SE +S  V        
Sbjct: 2503 ASVRSRLLRDPDGSAEDDSLEQTSL----MESSGKSPLSPDTPSSEEVSYEVTPKTTDVS 2558

Query: 2078 GVEPALGNEKEAHRSTPPFPEEKPLEESKM----VQSKVIDDADEGKKPSPEVKIPTQRK 2133
              +PA+ +E      +    +++   E +M     + K+ D+ ++  K   + K      
Sbjct: 2559 TPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYK------ 2612

Query: 2134 PISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKG----KKGISSFKSWMSSLFFGS 2189
                   +EP+  ES   + + P        D P+  G    + G+    +  S     S
Sbjct: 2613 -------KEPKQEESS--SSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVSSS 2663

Query: 2190 STPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLK----- 2244
            S  + ++A+ +  +   S  + + V  + P   +P++ +    P +     V  K     
Sbjct: 2664 SESEPELAQLK--KGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFK 2721

Query: 2245 ----TADEP-RGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSR----EDYGKKEIS 2295
                T +EP +    K  +    +++  + +  ED    K   +  +    + +G + +S
Sbjct: 2722 MNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGHGCEAMS 2781

Query: 2296 GDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSK-------RVQK 2348
              S    ++S + S  G++++ Q        ++ +E+  +   H  D++       R + 
Sbjct: 2782 PSSSAAPVSSGLQSPTGDDVDEQ-------PVIYKESLALQGTHEKDTEGEELDVSRAES 2834

Query: 2349 PAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPE 2408
            P    PS+ + S     P     +   L  D+         SA+S+     +TK  E  E
Sbjct: 2835 PQADCPSE-SFSSSSSLPHCLVSEGKELDEDI---------SATSSIQKTEVTKTDETFE 2884

Query: 2409 SIILPVE-ESKGSLIDFSEDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSYTL 2467
            +  LP +  S+ S I    DR    M  P S     +E  +     T   +N+ ++S+  
Sbjct: 2885 N--LPKDCPSQDSSITTQTDRF--SMDVPVSDLAENDE--IYDPQITSPYENVPSQSFFS 2938

Query: 2468 AEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNERP 2527
            +E+       N         S+E+    IT       +  S +  +            + 
Sbjct: 2939 SEESKTQTDANHTTSFH---SSEVYSVTITSPVEDVVVASSSSGTV----------LSKE 2985

Query: 2528 KIIVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFS 2587
                G + +   ++E+ ++ +         +P       +MS  + +     +GE  S  
Sbjct: 2986 SNFEGQDIKMESQQESTLWEMQSDSVSSSFEP-------TMSATTTV-----VGEQISKV 3033

Query: 2588 LVKATSVTEKSEAMLA------EAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALS 2641
            ++  T V   S + +       EA  +  E K  G      +      + T    P    
Sbjct: 3034 IITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMV-DRQSQGTTPDTTPARTPTEEG 3092

Query: 2642 CRDEIENHSLSQEGNL--VLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQ 2699
                 +N  L QEG L  +    + DM   S   E F   ++ +    +   E VK+G  
Sbjct: 3093 TPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEG-- 3150

Query: 2700 EKAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSE 2759
              A G  P PLE S                     E+ +LS+    V +++     D SE
Sbjct: 3151 --ATGADPLPLETS--------------------AESLALSESKETVDDEADLLPDDVSE 3188

Query: 2760 EKEQFKESELWKGGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQT 2819
            E E+   S+      + I   S     P+KE+     +     ++ + PP  LS VK  +
Sbjct: 3189 EVEEIPASDAQLNSQMGI---SASTETPTKEAVSVGTKDLPTVQTGDIPP--LSGVKQIS 3243

Query: 2820 LASGASPEINAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDT 2879
                + P +      ++  S LT   ++        D   D P  S    K  +E     
Sbjct: 3244 CPDSSEPAVQV----QLDFSTLTRSVYS--------DRGDDSPDSSPEEQKSVIE----- 3286

Query: 2880 RVKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSED 2939
                 + +A      F  + S      M ++   P   E   +  EDF  +      +++
Sbjct: 3287 -----IPTAPMENVPFTESKSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADE 3341

Query: 2940 QKTAFSI-ISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETV 2998
             K    + +    + +        +S+ +  + Q QD      +  S             
Sbjct: 3342 AKPKSKLPVKVPLQRVEQQLSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKT 3401

Query: 2999 ACHKTLKSRLEDEKVTPLKENKQK-----ETHKTKEEISTD-----SETDLSFIQ----P 3044
             C   +K+R   E  T  +E  ++     E   T+ +I T      S +  S  +    P
Sbjct: 3402 KC--PVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSP 3459

Query: 3045 TIPSEEDYFEKY-TLIDYNISPDPEKQKAPQKLNVEEKLSKEVTEETISF---------- 3093
            T  S+E +F+ Y   I++      E  K   +L   E+  + V+++  S           
Sbjct: 3460 TKESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENL 3519

Query: 3094 -PVSSVESALEHEYDLVKL-DESF------YGPEKGHNILSHPETQSQNSADR 3138
             PV +  S  E  +D   + DES          E GH+    P+ + +   +R
Sbjct: 3520 PPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEER 3572



 Score = 83.2 bits (204), Expect = 5e-15
 Identities = 329/1598 (20%), Positives = 577/1598 (36%), Gaps = 282/1598 (17%)

Query: 138  SKHGSPSLRRKGNRKRNSFESQDVPTNKKGSPLTSASQVLTTEKEKSYTGIYDKARKKKT 197
            SKH +     K  +++   E   V   K+  P+ +  +   TE +    G          
Sbjct: 2004 SKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRG---------- 2053

Query: 198  TSNTPPITGAIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELI------PLQFYGTLPKG 251
                 P+TG    +      R V + ++  K +     KE+++      P+Q   ++P+ 
Sbjct: 2054 --QRLPVTGTAESK------RGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQ---SVPEE 2102

Query: 252  YVIKEIHYRKGKDASISLEPDLDNSGSNTVSKT-RKLVAQSIEDKVKEVFPPWRGALSKG 310
               +E    K K A    + DL  S     S    +++ Q +ED  K  +  +R  LS+ 
Sbjct: 2103 ESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDK--YQQFR--LSEE 2158

Query: 311  SESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQSV------- 363
            +E   L   H DQ      SP N T  L++    +  +   + G     S+S+       
Sbjct: 2159 TEKAQL---HLDQ---VLTSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAG 2212

Query: 364  ----------PQQPEDEAKPHE--VEPPSVTPDTPATMFLRTTKEECELASPGTAASEND 411
                      PQ   +E+  HE   E P  +P++ +  F     EE           E  
Sbjct: 2213 SPCGSLMEGTPQISSEESYKHEGLAETPETSPESLS--FSPKKSEE--------QTGETK 2262

Query: 412  SSVSPSFANEVKKEDVYSAHHSISLEAASPGLAAS--TQDGLDPDQEQPDLTSIERAEPV 469
             S       E++ E  +     I+  +   G   +  ++   +  Q++  L S +   P 
Sbjct: 2263 ESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDTSPK 2322

Query: 470  SAKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEE 529
                     SV   KE         L+E    +E ++    ++       E ++S    +
Sbjct: 2323 RQDDCTGSCSVALAKET-----PTGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSD 2377

Query: 530  EIVELDYPESPLVSEKPFPPHMSPEVEHKEEELILPLLAASSPE--HVALSEEEREEIAS 587
            E   L  PE+ + ++           E K + +I       SP+   +AL   + E +++
Sbjct: 2378 ETKALPLPEASVKTDTG--------TESKPQGVI------RSPQGLELALPSRDSEVLSA 2423

Query: 588  VSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAP 647
            V+  S  VS +    + +  L++      P S      E + L E         SP    
Sbjct: 2424 VADDSLAVS-HKDSLEASPVLEDNSSHKTPDS-----LEPSPLKE---------SPCRDS 2468

Query: 648  TSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLAT 707
               S + P        +  PL + V    ++             PD  SA + S+   + 
Sbjct: 2469 LESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDG-SAEDDSLEQTSL 2527

Query: 708  KESLKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQS 767
             ES       KSPL                DT        P+SE  +S   T KT++  +
Sbjct: 2528 MES-----SGKSPL--------------SPDT--------PSSE-EVSYEVTPKTTDVST 2559

Query: 768  PLPSTATSEHVVPSEGEDLGSERFTPDS---KLISKYAAPLNATQESQKKIINEASQFKP 824
            P P+    E     + E+   +RFTP+    K+++K        QE+++K       +K 
Sbjct: 2560 PKPAVI-HECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQK-----RDYKK 2613

Query: 825  KGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSD 884
            +   E +  S         S PD   + +   P HT     E   P L  + S  V  S 
Sbjct: 2614 EPKQEESSSS---------SDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVSSSS 2664

Query: 885  EEAVELERYTPSSTSA--SEFSV---PPYATPEAQE-----EEIVHRSLNLKGASSPMNL 934
            E   EL +    + S    E  +   PP   P + +     EE+  + +  K  +  MN 
Sbjct: 2665 ESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMN- 2723

Query: 935  SEEDQEDIGPFSPDSAFVSEFSFPPYA-TQEAEKREFE-----------CD-------SP 975
             E+ QE+ G    +    S  +   +A + EAE R ++           CD       SP
Sbjct: 2724 -EDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGHGCEAMSP 2782

Query: 976  ICLTSPSEHTILS--DEDTEEAELFSPDSASQVSIPPFRISETEKNELE----------- 1022
                +P    + S   +D +E  +   +S   +++      +TE  EL+           
Sbjct: 2783 SSSAAPVSSGLQSPTGDDVDEQPVIYKES---LALQGTHEKDTEGEELDVSRAESPQADC 2839

Query: 1023 PDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPP 1082
            P    ++ S+  +   SE  E D   +A + + +   +   +  E  P   P +D S+  
Sbjct: 2840 PSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITT 2899

Query: 1083 STDK----------SEKAEI-KPEIPTTSTSV-SEYLILAQKQKTQAYLEP----ESEDL 1126
             TD+          +E  EI  P+I +   +V S+    +++ KTQ          S ++
Sbjct: 2900 QTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSFHSSEV 2959

Query: 1127 IPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEP 1186
                +TS VE     +SSS   +      +   +K E++  S  ++      ++    EP
Sbjct: 2960 YSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQES--TLWEMQSDSVSSSFEP 3017

Query: 1187 TAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDM 1246
            T + T     EQ++   + K ++  DS    + + +D   E     V E E K   L  M
Sbjct: 3018 TMSATTTVVGEQISKVIITKTDVDSDS---WSEIREDD--EAFEARVKEEEQKIFGL--M 3070

Query: 1247 VDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHD 1306
            VD   +G  P      T   E    S+  P + +    L E + SG  A+   K     +
Sbjct: 3071 VDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQE-GKLFEMTRSG--AIDMTKRSYADE 3127

Query: 1307 S-----------KITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKE-------IE 1348
            S           + T +  V   A+      +E    +LA S   E +  E       + 
Sbjct: 3128 SFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDDVS 3187

Query: 1349 PSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPLVTSAD 1408
                   AS  +L+S +  +   E PT  ++   V    L  V  G+    +PPL  S  
Sbjct: 3188 EEVEEIPASDAQLNSQMGISASTETPTKEAV--SVGTKDLPTVQTGD----IPPL--SGV 3239

Query: 1409 EHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPSVSSIAE--HSVLSEVEAK 1466
            +     +  + A++      T ++ + +S+   +    S     S+ E   + +  V   
Sbjct: 3240 KQISCPDSSEPAVQVQLDFSTLTRSV-YSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFT 3298

Query: 1467 EVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSSQKKSLMSTSEVLEPE 1526
            E K+ +PV    +S  +  S E      +D L S   D E      K           P+
Sbjct: 3299 ESKSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSV--DEENKADEAK-----------PK 3345

Query: 1527 HELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSSPELENLASGLAPTLLL 1586
             +LP+    ++  +  E   S   +   K + P+G+D   AS +P+  + +   A +L  
Sbjct: 3346 SKLPV----KVPLQRVEQQLSDLDTSVQKTVAPQGQD--MASIAPDNRSKSESDASSL-- 3397

Query: 1587 LSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEK 1624
              D K K  V+  S  + +  S ++     EL LE E+
Sbjct: 3398 --DSKTKCPVKTRSYTETETESRER---AEELELESEE 3430



 Score = 65.9 bits (159), Expect = 8e-10
 Identities = 510/2718 (18%), Positives = 953/2718 (35%), Gaps = 462/2718 (16%)

Query: 415  SPSFANEVK--KEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPD--LTSIERAEPVS 470
            SP   +EV   K+D+      ++ + +    +   ++ +   +E+P      +ER +   
Sbjct: 1500 SPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDL 1559

Query: 471  AKLTPTHPSVKGEKEENMLEPSISL-----SEPLMLEEPEKEEIETSLPIAITPEPEDSN 525
             K+     S    ++E+ ++ S S       E +++ + E EE     P+ IT  P    
Sbjct: 1560 EKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEV 1619

Query: 526  LVEEEI---VELD------YPESPLVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVA 576
             +++EI   VE D      Y    L +  P P      V+ K  +    L    S     
Sbjct: 1620 RIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRS----- 1674

Query: 577  LSEEEREEIA---SVSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEE 633
             SE+E ++I    + ST         + + +  +L+E++ +      ++A AE A L + 
Sbjct: 1675 -SEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQK--EEGLQASAEKAELKKG 1731

Query: 634  ENEEFEAYSPAAAPT---SESSLSPSTTE----KTSENQSPLFSTVTPEYM--------V 678
             +EE     P  AP    +  + SP   E       +    L   V  E          V
Sbjct: 1732 SSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRV 1791

Query: 679  LSGDEASESGCYTPDSTSA----SEYSVPSL--------ATKESLKKTIDRKSPLILKGV 726
               ++  +   + P   ++    SE   P          +T  S  KT +R  P+     
Sbjct: 1792 KGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKT-ERHPPVSPSSK 1850

Query: 727  SEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEH--VVPSEGE 784
            +E   P      T   +PA + +     SP +    +E  SP+ ST T  H  V PS   
Sbjct: 1851 TEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKT 1910

Query: 785  DL--------GSERFTPDSKLISKYAAPLNATQESQK-KIINEASQFKPKGISEHTVLSV 835
            D          +E+  P S   ++   P++ +  + K + ++ A +       +H  +S 
Sbjct: 1911 DKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGK-----TEKHLPVSP 1965

Query: 836  DGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYV--VLSDEEAVELERY 893
             GK       P +   S+      T  +    +A      PS++   +   + A + +  
Sbjct: 1966 SGKT---EKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQ 2022

Query: 894  TPSSTSASEFSVPPYATPEAQ--EEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAF 951
                    +   P     EAQ  E + + R   L    +  +        IG    D+A 
Sbjct: 2023 EKGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAG 2082

Query: 952  VSEFSFP---PYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSI 1008
              E       P   Q   + E   +S +    P E   ++DE  +     SPD  +    
Sbjct: 2083 GKEKVLSHKIPEPVQSVPEEESHRESEV----PKEK--MADEQGDMDLQISPDRKTSTDF 2136

Query: 1009 --------------PPFRIS-ETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATP 1053
                            FR+S ETEK +L  D +LT+   + +      DE     +  + 
Sbjct: 2137 SEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSG 2196

Query: 1054 VSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTS---------TSVS 1104
              +  S S K +         L + +   S+++S K E   E P TS          S  
Sbjct: 2197 ALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEE 2256

Query: 1105 EYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEET 1164
            +     +  KT+   E  SE   P+  T ++  G  E  ++V     +  +  S  KE T
Sbjct: 2257 QTGETKESTKTETTTEIRSEKEHPT--TKDITGGSEERGATVT--EDSETSTESFQKEAT 2312

Query: 1165 KPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQE---ATAHVS 1221
               SP    P      K++ + T + ++  A E    + + +E    + Q    ++AH +
Sbjct: 2313 L-GSPKDTSP------KRQDDCTGSCSVALAKE--TPTGLTEEAACDEGQRTFGSSAHKT 2363

Query: 1222 QDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGV--KPKLVLNVTSELEQRKLSKNEPEVI 1279
            Q    E Q       E K   LP+   +   G   KP+ V+     LE    S++     
Sbjct: 2364 QTDS-EVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDS---- 2418

Query: 1280 KPYSPLKETSLSGPEALSAV---KMEMKHDSKITTTPIVLHSASSGVEKQVEHGP----- 1331
                          E LSAV    + + H   +  +P++  ++S      +E  P     
Sbjct: 2419 --------------EVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESP 2464

Query: 1332 --PALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLT 1389
               +L  S +  ++K  I PS     A+V K     T  + E     S L+   D     
Sbjct: 2465 CRDSLESSPVEPKMKAGIFPSHFPLPAAVAK-----TELLTEVASVRSRLLRDPD----- 2514

Query: 1390 KVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLP 1449
                            SA++ S L +   +   G SP+         + + +E+ ++  P
Sbjct: 2515 ---------------GSAEDDS-LEQTSLMESSGKSPLSPD------TPSSEEVSYEVTP 2552

Query: 1450 SVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLV 1509
              +              +V    P +    ++  D                   + +R  
Sbjct: 2553 KTT--------------DVSTPKPAVIHECAEEDDSENG---------------EKKRFT 2583

Query: 1510 SSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASS 1569
              ++   M T   +  E E       + KK+  +  SS +  P +   +   + + T S 
Sbjct: 2584 PEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSG 2643

Query: 1570 SPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKDKPH 1629
              E     SG+   +L+ S+ +     +VSS+++ + P   Q    A+  L PE   +  
Sbjct: 2644 EDE-----SGV--PVLVTSESR-----KVSSSSESE-PELAQLKKGADSGLLPEPVIRVQ 2690

Query: 1630 QPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRELC 1689
             P  LP++    SS    Q   + +KQ    + E       K   E  S     E+R   
Sbjct: 2691 PPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRH-- 2748

Query: 1690 ASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPAS---VAEGGNPEEFQPFTF 1746
            A ST         L R+  Q +       + +S  S   P S    +  G+  + QP  +
Sbjct: 2749 AVSTEAEDRSYDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIY 2808

Query: 1747 SLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNSSQVLQSI 1806
              + L+ + +H  D +                     G+ LD    E+  P +    +S 
Sbjct: 2809 K-ESLALQGTHEKDTE---------------------GEELDVSRAES--PQADCPSESF 2844

Query: 1807 TEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRENLPLEQS 1866
            +  S + P  L+ E K+ ++ + +  +++  +V+ + E  ++L  K       ++  +  
Sbjct: 2845 SSSSSL-PHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLP-KDCPSQDSSITTQTD 2902

Query: 1867 KSFMTTKPADVKE---------------TKMEEFFISPKDENWMLGKPENVASQHEQRIA 1911
            +  M    +D+ E                  + FF S  +E+       +  S H   + 
Sbjct: 2903 RFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSS--EESKTQTDANHTTSFHSSEVY 2960

Query: 1912 GSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEES---HLSSQEAVSALDTS 1968
             SV + S   + +        V SK+   E  + +   S +ES    + S    S+ + +
Sbjct: 2961 -SVTITSPVEDVVVASSSSGTVLSKESNFE-GQDIKMESQQESTLWEMQSDSVSSSFEPT 3018

Query: 1969 SGNTETLSSKSYSSEEV-----------KLAEEPKSLVLAGNVERNIAEGKEIHSLMESE 2017
               T T+  +  S   +           ++ E+ ++       E     G  +    +  
Sbjct: 3019 MSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGT 3078

Query: 2018 SLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAE 2077
            +     A T     +    Q        + F+   SG +++  K      S        E
Sbjct: 3079 TPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSG-AIDMTKRSYADESFHFFQIGQE 3137

Query: 2078 GVEPALGNE-KEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKP---SPEV-KIPTQR 2132
              E  L  + KE      P P E   E   + +SK   D +    P   S EV +IP   
Sbjct: 3138 SREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASD 3197

Query: 2133 KPISSIH--AREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGIS-------------S 2177
              ++S    +   ++P    V+      P V   D+P   G K IS              
Sbjct: 3198 AQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSSEPAVQVQLD 3257

Query: 2178 FKSWMSSLFF--GSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPAD 2235
            F +   S++   G  +PD+   EQ+ +   P+  +E  V   + +  IP        PA 
Sbjct: 3258 FSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMEN-VPFTESKSKIPVRTMPTSTPAP 3316

Query: 2236 HSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSREDYGKKEIS 2295
             S +E +   +++   ++ +       K KS +   V   +  + +S++  +   +K ++
Sbjct: 3317 PS-AEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQLSDL--DTSVQKTVA 3373

Query: 2296 GDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPS 2355
               ++M   + +   +    E  + SL  +     + ++         +R ++  +    
Sbjct: 3374 PQGQDM---ASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRERAEELEL---- 3426

Query: 2356 KWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESIILPVE 2415
                    E      + K L S     ++P + +S +S+                  P +
Sbjct: 3427 --------ESEEGATRPKILTS-----RLPVKSRSTTSSCRGGT------------SPTK 3461

Query: 2416 ESKGSLIDFSEDRLK--KEMQNPTSL---KISEEETKLRSVSPTEKKDNLENRSYTLAEK 2470
            ESK    D   + ++  +E+ +  S    ++++ E +   VS  E    LE    ++ E 
Sbjct: 3462 ESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALE---VSVIEN 3518

Query: 2471 KVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNERPKII 2530
                E ++SV P ++ D+  I    I          E+  + +P       D+ E P+  
Sbjct: 3519 LPPVETEHSV-PEDIFDTRPIWDESI----------ETLIERIPDE--NGHDHAEDPQ-- 3563

Query: 2531 VGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVK 2590
               E+E+ EE+    Y+              ++  E    +  I   +SL + QS +L+K
Sbjct: 3564 --DEQERIEER--LAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSL-QDQSHALLK 3618

Query: 2591 ---ATSVTEKSEAMLAEAHPEIREAKAV---GTQPHPLEE----SKVLVEKTKTFLPVAL 2640
                      ++  L E   +I     V    T   PL+E    S   +E+T T      
Sbjct: 3619 YWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITL----- 3673

Query: 2641 SCRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQE 2700
               D  E  S+ QE     +   +      EE+   +ESE      + +++E +  G+  
Sbjct: 3674 ---DHSEGFSVLQEELCTAQHKQK------EEQAVSKESETCDHPPI-VSEEDISVGYST 3723

Query: 2701 KAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEE 2760
               G  P+   +S       +T        H E      S +         +D+P+ S  
Sbjct: 3724 FQDGV-PKTEGDSSATALFPQT--------HKEQVQQDFSGK--------MQDLPEESSL 3766

Query: 2761 KEQFKESELWKGGSVDITKESM-KEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQT 2819
            + Q +      G     T+++M     PSK  E         T + E   YL +P   + 
Sbjct: 3767 EYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEV------STPAEEEKLYLQTPTSSE- 3819

Query: 2820 LASGASPEINAVKKKEMPRSELTPERHTVHTIQTSK------------------DDTSDV 2861
               G SP I   ++    R E +P + ++  ++++                   DD  ++
Sbjct: 3820 --RGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEI 3877

Query: 2862 PKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTY 2921
            P ++V   + +++    T VK+     +    +++S+      + MV    MP+EP +  
Sbjct: 3878 PPETV-TEEEYIDEHGHTVVKK---VTRKIIRRYVSSEGTEKEEIMVQG--MPQEPVN-I 3930

Query: 2922 AKGEDFTVTSKPAGLSED 2939
             +G+ ++   K   L  D
Sbjct: 3931 EEGDGYSKVIKRVVLKSD 3948



 Score = 33.5 bits (75), Expect = 4.4
 Identities = 91/441 (20%), Positives = 156/441 (35%), Gaps = 35/441 (7%)

Query: 2530 IVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFS-- 2587
            I   E E  +E+E ++ + SE   + E    SV  +  ++    ++    L E       
Sbjct: 1454 IYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQD 1513

Query: 2588 LVKATSVTEKSEAMLAEAHPEIREAKAVGTQPHP----LEESKVLVEKTKTFLPVALSCR 2643
            L+K T++     +  A +       KA   +P      +E  K  +EK    L      R
Sbjct: 1514 LIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTR 1573

Query: 2644 DEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEK-A 2702
            DE    S   E  LV E+      +  EE  Q    E+++   V++  +   +G  EK +
Sbjct: 1574 DESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKEIKGKVEKDS 1633

Query: 2703 VGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMP--DHSEE 2760
             G      ++    V   K  L  V    D+      +       EK  +D+P  +    
Sbjct: 1634 TGLVNYLTDDLNTCVPLPKEQLQTV---QDKAGKKCEALAVGRSSEKEGKDIPPDETQST 1690

Query: 2761 KEQFKESELWKGGSVDITKESMK---EGFPSKESERTLARPFDETKSSETP---PYLLSP 2814
            ++Q K S   K       KE  K   EG  +   +  L +   E    E P   P  L  
Sbjct: 1691 QKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPT 1750

Query: 2815 VKPQTLASGASPEINAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSV-------- 2866
            VK  +     +P  +   K +  +  +  E+     +        DVPK++         
Sbjct: 1751 VKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAAS 1810

Query: 2867 --LVSKHHLEAAEDTRVKEP---LSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTY 2921
              L S+ H   +   + +      SSAK+     +S +S +     VS    P    + +
Sbjct: 1811 PSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVS----PSAKTERH 1866

Query: 2922 AKGEDFTVTSKPAGLSEDQKT 2942
            +     + T K + +S   KT
Sbjct: 1867 SPASSSSKTEKHSPVSPSTKT 1887



 Score = 32.7 bits (73), Expect = 7.5
 Identities = 58/264 (21%), Positives = 94/264 (35%), Gaps = 44/264 (16%)

Query: 3296 EEQKGVYGEGESVDHVE-------TVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHV 3348
            +E++ V  E E+ DH         +VG    Q   P TE    AT        F  TH  
Sbjct: 3694 KEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATAL------FPQTHKE 3747

Query: 3349 LERADEAG--------------------SHGNEVGNAS-----PEVNLNVPVQVSFP-EE 3382
              + D +G                    + G E          P      P +VS P EE
Sbjct: 3748 QVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEE 3807

Query: 3383 EFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSEELS 3442
            E     T         P I  P EPSE R  +SP +      ES  N+    + L E+ +
Sbjct: 3808 EKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAA 3867

Query: 3443 SESTPE--DVLSQGKESFEHISENEFASEAEQSTPAEQKELGSERKEEDQLSSEVVTEKA 3500
             E   +  ++  +     E+I E+      + +    ++ + SE  E++++   +V    
Sbjct: 3868 FEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEI---MVQGMP 3924

Query: 3501 QKELKKSQIDTYCYTCKCPISATD 3524
            Q+ +   + D Y    K  +  +D
Sbjct: 3925 QEPVNIEEGDGYSKVIKRVVLKSD 3948


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 329/1647 (19%), Positives = 580/1647 (35%), Gaps = 245/1647 (14%)

Query: 1041 ADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPT-- 1098
            AD  +    AA P+  +  S +K+  E  P ++ +  +  PP  +  EK  +K + P   
Sbjct: 539  ADSRESLKPAAKPLPSK--SVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKT 596

Query: 1099 -TSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQS 1157
             T  SV+E  +            P  E+  PS + +EV   E++A+      P A  A+ 
Sbjct: 597  ETKPSVTEKEV------------PSKEE--PSPVKAEV--AEKQATD---VKPKA--AKE 635

Query: 1158 SIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEAT 1217
              VK+ETK            P  KKE++      +   +++  + K  K +     +E  
Sbjct: 636  KTVKKETKVK----------PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK 685

Query: 1218 AHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPE 1277
              + +++K EP+                   E KK   PK V     + E++++ K E E
Sbjct: 686  KEIKKEEKKEPKK------------------EVKKETPPKEVKKEVKKEEKKEVKKEEKE 727

Query: 1278 VIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFS 1337
              K    L + +      LS  K       K+      +   S    K  E G   +   
Sbjct: 728  PKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKK 787

Query: 1338 ALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLI-TPVDRPVLT------K 1390
                         +  TTA+V            +E+  + SL+ +P D   LT      K
Sbjct: 788  EGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPED---LTKDFEELK 844

Query: 1391 VGKGELGSGLPPLVTSADEHSVLAEEDKV----------AIKGASPIETSSKHLAWSEAE 1440
              + ++   + P +   ++   L E + V            KG  P E+  + +  +E E
Sbjct: 845  AEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKG--PAESPDEGITTTEGE 902

Query: 1441 KEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFS 1500
             E   +  P      E   + ++E  E +       + +  + +K+E    E+ ++    
Sbjct: 903  GEC--EQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEE 960

Query: 1501 TVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPK 1560
             VC     VS+ K S     E  + E +  +      +K+E+               I K
Sbjct: 961  HVC-----VSASKHSPTEDEESAKAEADAYIR-----EKRESVASGDDRAEEDMDEAIEK 1010

Query: 1561 GKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSL 1620
            G+ E++   + E +             ++D  +   E       D+     D A      
Sbjct: 1011 GEAEQSEEEADEEDK------------AEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGA 1058

Query: 1621 EPEK--KDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRS 1678
            E +      P + L   + G E +S +  ++   G   ++S  T +++   E  P E  +
Sbjct: 1059 EEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGG---SESEATASDEENREDQPEEFTA 1115

Query: 1679 REGKEENR-ELCASST-MPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGG 1736
              G  ++  E+ +  T M  +S    ++ +E+ NEE +  S + +++   E      E  
Sbjct: 1116 TSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYS 1175

Query: 1737 NPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVM--GDILDKLSEET 1794
             P +  P    L G SE     A   K  N     + P  +++        + D    E 
Sbjct: 1176 KPADVTP----LNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEV 1231

Query: 1795 GHPNSSQVLQSITEPS--KIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSE---DKQDL 1849
                +  +  SI+  S  K++PS                   K P +S S     +K  L
Sbjct: 1232 KASTTLDIKDSISAVSSEKVSPS-------------------KSPSLSPSPPSPLEKTPL 1272

Query: 1850 GIK--QFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHE 1907
            G +   FSL    + +          P +V +  +EE   SP+D+   +  P    SQ  
Sbjct: 1273 GERSVNFSLTPNEIKVSAEAEVAPVSP-EVTQEVVEEHCASPEDKTLEVVSP----SQSV 1327

Query: 1908 QRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDT 1967
               AG      S ++E +   L   V  K     V  +      E    S    VS +D 
Sbjct: 1328 TGSAGHTPYYQSPTDE-KSSHLPTEVIEKPPAVPVSFEFSDAKDENERAS----VSPMDE 1382

Query: 1968 SSGNTETLSSK------------SYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIH---- 2011
               ++E+   K            S S+ E  L+ + K+             GK+      
Sbjct: 1383 PVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQV 1442

Query: 2012 ---SLMESESLLLEK---ANTELSWPSKED-SQEKIKLPPERFFQKPVSGLSVEQVKSET 2064
               S M S SL  +K    +T+ + P KED  QEK     E    +P   L  E+   + 
Sbjct: 1443 SPVSEMTSTSLYQDKQEGKSTDFA-PIKEDFGQEKKTDDVEAMSSQPALALD-ERKLGDV 1500

Query: 2065 ISSSVKTAHFPA--EGVEPALGNEKEAHRSTPPFPE---EKPLEESKMVQSKVIDDADEG 2119
              + +  + F +  E  + ++     + +S  P  E   E      + V S         
Sbjct: 1501 SPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATS 1560

Query: 2120 KKPSPEVK--IPTQRKPISSIHAREPQSPESPEVTQNP---------------PTQPKVA 2162
              P P      P+    + S H+ E     S  V Q P               P    ++
Sbjct: 1561 SFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSIS 1620

Query: 2163 KPDLPEE--KGKKGISSFKSWMSSLF--FGSSTPDNKVAEQEDLETQPSPSVEKAVTVID 2218
             PD   +  K +  +   +S  SS+   FG  +P+  +A     ++   P+V   V  I 
Sbjct: 1621 PPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHIT 1680

Query: 2219 PEGTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILS--NVEDLQ 2276
              G    +++ ++   D SLS  K+   +EP  T  +  D   +   S + +  +     
Sbjct: 1681 ENGPTEVDYSPSDM-QDSSLSH-KIPPMEEPSYT--QDNDLSELISVSQVEASPSTSSAH 1736

Query: 2277 QPKFISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIV 2336
             P  I+   +ED           +M++ + +TS   ++LE       GEKL     K+ +
Sbjct: 1737 TPSQIASPLQED--TLSDVAPPRDMSLYASLTSEKVQSLE-------GEKL---SPKSDI 1784

Query: 2337 PPHVTDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFA 2396
             P    + R   P  +P    + S  KE+  +     S      +D    +P    ++  
Sbjct: 1785 SPL---TPRESSPLYSPTFSDSTSAVKEKTATCHSSSS----PPIDAASAEPYGFRASVL 1837

Query: 2397 SKNITKESEKPESIILP-VEESKGSLI--DFSEDRLKKEMQNPTSLKISEEETKLRSVSP 2453
               +         +  P +E+  G     DFS    K E    T+    EE+    S   
Sbjct: 1838 FDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPE---ETTRSPDEEDYDYESYEK 1894

Query: 2454 TEKKDNLENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITL--GSRSTELKESKAD 2511
            T +  ++    Y   E+   +   +  +         IGKT  T   G  S E+ E K  
Sbjct: 1895 TTRTSDVGGYYYEKIERTTKSPSDSGYS------YETIGKTTKTPEDGDYSYEIIE-KTT 1947

Query: 2512 AMPQHFYQNEDYNER---PKIIVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESM 2568
              P+    + D +E+   P  + G   EK E     +  +S G    E   +++    S 
Sbjct: 1948 RTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLG-DPSY 2006

Query: 2569 SRESDISLGHSLGETQSFSLVKATSVT 2595
            S E+   +  S  E++ +S   +T  T
Sbjct: 2007 SYETTEKI-TSFPESEGYSYETSTKTT 2032



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 278/1345 (20%), Positives = 471/1345 (35%), Gaps = 220/1345 (16%)

Query: 453  PDQEQPDLTSIERAEPVSAKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKE--EIE 510
            P +E+P     E AE  +  + P     K  K+E  ++P     E    E+P+KE  + E
Sbjct: 608  PSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEK---EKPKKEVAKKE 664

Query: 511  TSLPIAITPEPEDSNL---VEEEIVELDYPESPLVSEKPFPP-HMSPEVEHKEEELILPL 566
               PI    +P+   +   V++EI + +  E     +K  PP  +  EV+ +E++ +   
Sbjct: 665  DKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEV--- 721

Query: 567  LAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQE----------GEPV 616
                  E     +E ++        S  +SE   P  L  ++ ++E          G+P 
Sbjct: 722  ----KKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPK 777

Query: 617  PPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEKTSENQSPLFST---VT 673
                ++ I +    +E         +  AA  + + ++     K  E +  L S+   +T
Sbjct: 778  EKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLT 837

Query: 674  PEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSPLILKGVSEYMIPS 733
             ++  L  +E         D T   +  +  +  +E LK+T         + V  Y+I  
Sbjct: 838  KDFEELKAEEV--------DVTKDIKPQLELIEDEEKLKET---------EPVEAYVIQK 880

Query: 734  EEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSEGEDLGSERFTP 793
            E +   G       PA  P    +TTE   EC+       T E + P E + +       
Sbjct: 881  EREVTKG-------PAESPDEGITTTEGEGECEQ------TPEELEPVEKQGVDD----- 922

Query: 794  DSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHT-VLSVDGKEVIGPSSPDLVVAS 852
                I K+       +ES     +E   ++ K  +E       DG+E +       V AS
Sbjct: 923  ----IEKFEDEGAGFEES-----SETGDYEEKAETEEAEEPEEDGEEHV------CVSAS 967

Query: 853  EHSFPPHTTEMTSECQAPPLSATPSEYVVLSD-------EEAVELERYTPSSTSASEFSV 905
            +HS  P   E +++ +A        E V   D       +EA+E      S   A E   
Sbjct: 968  KHS--PTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDK 1025

Query: 906  PPYATPEAQEEE----------IVHRSLNLKGASSPMNLSEEDQEDIGPFSP---DSAFV 952
               A  E  E E          +V ++    GA           + +G  SP    ++ +
Sbjct: 1026 AEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSI 1085

Query: 953  SEFSFPPYATQEA-----EKREFECDSPICLTSPSEHTI-LSDEDTEEAELFSP------ 1000
             + + P  +  EA     E RE + +     +  ++ TI +S E T   E+ +P      
Sbjct: 1086 HDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSD 1145

Query: 1001 -------DSASQ--VSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAA 1051
                   +S SQ  V+I  +  S   +   +P  +      S  S     D +D  ++A+
Sbjct: 1146 ETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASAS 1205

Query: 1052 T--PVS----EQFS--------SSQKQKAETFPLMSPLEDLSLPP-STDKSEKAEIKPEI 1096
            T  P S    ++FS         S+ + + T  +   +  +S    S  KS      P  
Sbjct: 1206 TISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPS 1265

Query: 1097 PTTSTSVSEYLILAQKQKTQAYLEPESEDL-IPSHLTSEVEKGEREASSSVAAIPAALPA 1155
            P   T + E  +       +  +  E+E   +   +T EV + E  AS     +    P+
Sbjct: 1266 PLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVE-EHCASPEDKTLEVVSPS 1324

Query: 1156 QSSIVKEETKP--ASPHSVLPDSVPAIKKEQEPTAALTLK---AADEQMALSKVRKEEIV 1210
            QS        P   SP       +P    E+ P   ++ +   A DE    S    +E V
Sbjct: 1325 QSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPV 1384

Query: 1211 PDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRK 1270
            PDS+     V    +    PP +       S L    D+   G          S  E++ 
Sbjct: 1385 PDSESPIEKVLSPLR---SPPLIGSESAYESFL--SADDKASG------RGAESPFEEKS 1433

Query: 1271 LSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITT-TPIVLHSASSGVEKQVE- 1328
              +  P+ + P S +  TSL           + K + K T   PI       G EK+ + 
Sbjct: 1434 GKQGSPDQVSPVSEMTSTSL----------YQDKQEGKSTDFAPI---KEDFGQEKKTDD 1480

Query: 1329 ----HGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVD 1384
                   PAL   AL E    ++ P +    +       +   ++ E   +D S  TPVD
Sbjct: 1481 VEAMSSQPAL---ALDERKLGDVSP-TQIDVSQFGSFKEDTKMSISEGTVSDKS-ATPVD 1535

Query: 1385 RPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIK 1444
              V           G+  + T++   S   E     +  +   E  S H          +
Sbjct: 1536 EGVAEDTYSHM--EGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPH--------STE 1585

Query: 1445 FDSLPSVSSIAEHSVLSEVEAKEVKAGLP-VIKTSSSQHSDKSEEAR--VEDKQDLLFST 1501
             D   SVS +   +   E E    K   P  +  S    S K+ ++R  V+D +      
Sbjct: 1586 VDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHR------ 1639

Query: 1502 VCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKG 1561
                     S++ S+        PE  L +           + P    V     HI   G
Sbjct: 1640 ---------SEQSSMSIEFGQESPEQSLAMDF-------SRQSPDHPTVGAGVLHITENG 1683

Query: 1562 KDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGD-FPSEKQDVALAELS- 1619
              E   S S   ++  S   P +   S  ++    E+ S +Q +  PS       ++++ 
Sbjct: 1684 PTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIAS 1743

Query: 1620 -LEPEKKDKPHQPLELPNAGSEFSSDLGRQSG-SIGTKQAKSPITETEDSVLEKGPAELR 1677
             L+ +       P ++    S  S  +    G  +  K   SP+T  E S L   P    
Sbjct: 1744 PLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPL-YSPTFSD 1802

Query: 1678 SREGKEENRELCASSTMPAISELSS 1702
            S    +E    C SS+ P I   S+
Sbjct: 1803 STSAVKEKTATCHSSSSPPIDAASA 1827



 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 261/1260 (20%), Positives = 430/1260 (34%), Gaps = 253/1260 (20%)

Query: 2326 KLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVP 2385
            K V +E+K   P  VT    V+KP     SK  + + K++P   + + S+   +V  K  
Sbjct: 555  KSVRKESKEETP-EVTKVNHVEKPPKVE-SKEKVMVKKDKPIKTETKPSVTEKEVPSK-- 610

Query: 2386 QQPKSASSNFASKNITKESEKPESIILPVEESKGSLIDFSEDR-------LKKEMQNPTS 2438
            ++P    +  A K  T    K        +E+K    D  E++        KKE + P  
Sbjct: 611  EEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIK 670

Query: 2439 L--KISEEETKLRSVSPTEKKDNLENRSYTLAE-------KKVLAEKQNSVAPLELRDSN 2489
               K  +EE K       +K++  E +     E       K+V  E++  V   E     
Sbjct: 671  KEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKK 730

Query: 2490 EIGKTQITLGSRSTELKESKADA-MPQHFYQNEDYNERPKIIVGSEKEKGEEKENQVYVL 2548
            EI K        ST L E+K  A +     + E+  ++  +  G  KEKG+ K     + 
Sbjct: 731  EIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIK----VIK 786

Query: 2549 SEGKKQQEHQPY---SVNVAESMSRESDISLGHSLGETQSFSLVKATS-VTEKSEAMLAE 2604
             EGK  +            A  M+     ++G +       SL+ +   +T+  E + AE
Sbjct: 787  KEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAE 846

Query: 2605 AHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQEGNLVLEKSSR 2664
               E+   K +  Q   +E+ + L E       V    R+  +  + S +  +   +   
Sbjct: 847  ---EVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEG 903

Query: 2665 DMPDHSEEKEQFRESELSKGGSVDITK-ETVKQGFQEKAVG---TQPRPLEESKVLVEKT 2720
            +     EE E      + K G  DI K E    GF+E +      +    EE++   E  
Sbjct: 904  ECEQTPEELEP-----VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDG 958

Query: 2721 KTFLPVVLSCHDEIENH-SLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVDITK 2779
            +  + V  S H   E+  S   E +  + +    +    +  E+  +  + KG +    +
Sbjct: 959  EEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEE 1018

Query: 2780 ESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTLASGASPEINAVKKKEMPRS 2839
            E+ +E       E        E +  E   Y+++ V     A GA  +   +        
Sbjct: 1019 EADEEDKAEDAREEEY-----EPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLG 1073

Query: 2840 ELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLS-SAKSNYAQFISN 2898
              +P R    +I    D+T     +S   +       E+ R  +P   +A S Y Q    
Sbjct: 1074 AQSPGREPASSIH---DETLPGGSESEATASD-----EENREDQPEEFTATSGYTQ---- 1121

Query: 2899 TSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQKTAFSIISEGCEILNIHA 2958
                      S  E+  EP             S P  +  D+       S   E +NI  
Sbjct: 1122 ----------STIEISSEPTP-------MDEMSTPRDVMSDETNNEETESPSQEFVNI-- 1162

Query: 2959 PAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVACHKTLKSRLEDEKVTPLKE 3018
              + SS+  +E  +  D                                     VTPL  
Sbjct: 1163 TKYESSLYSQEYSKPAD-------------------------------------VTPL-- 1183

Query: 3019 NKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLIDY----------------- 3061
            N   E  KT      D     S I P    EED F +  L D                  
Sbjct: 1184 NGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSI 1243

Query: 3062 --------------NISPDPEK--QKAPQ--------------KLNVEEK---LSKEVTE 3088
                          ++SP P    +K P               K++ E +   +S EVT+
Sbjct: 1244 SAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQ 1303

Query: 3089 ETISFPVSSVESALEHEYDLVKLDESFYGPEKGHNILSHPETQSQNSADRNVSKDTKRDV 3148
            E +    +S E   +   ++V   +S  G   GH       T    S     S     +V
Sbjct: 1304 EVVEEHCASPE---DKTLEVVSPSQSVTG-SAGH-------TPYYQSPTDEKSSHLPTEV 1352

Query: 3149 DSKSPGMPL---FEAEEGVLSRTQIFPTTIKVIDPEF--------LEEPPAL-------A 3190
              K P +P+   F   +    R  + P    V D E         L  PP +       +
Sbjct: 1353 IEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYES 1412

Query: 3191 FLYKDLYEEAVG---EKKKEEETASEG--DSVN--SEASFPSRNSDTDDGTGIYFEKYIL 3243
            FL  D  ++A G   E   EE++  +G  D V+  SE +  S   D  +G    F    +
Sbjct: 1413 FLSAD--DKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAP--I 1468

Query: 3244 KDDI-----LHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKF----------GT 3288
            K+D        D           L+E+++G      P   +   +G F          GT
Sbjct: 1469 KEDFGQEKKTDDVEAMSSQPALALDERKLG---DVSPTQIDVSQFGSFKEDTKMSISEGT 1525

Query: 3289 ICREKSLEEQKGVYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHV 3348
            +  + +    +GV    ++  H+E V +V+            VAT   S+  P  D    
Sbjct: 1526 VSDKSATPVDEGV--AEDTYSHMEGVASVS---------TASVATS--SFPEPTTDDVSP 1572

Query: 3349 LERADEAGSHGNEVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPS 3408
               A+    H  EV ++     +  P   +F E E +       +     P  + PP+ S
Sbjct: 1573 SLHAEVGSPHSTEVDDSLSVSVVQTP--TTFQETEMSP-----SKEECPRPMSISPPDFS 1625

Query: 3409 EERLRN-SPVQDEYEFTESLHNEV---VPQDILSEELSSESTPEDVLSQGKESFEHISEN 3464
             +  ++ +PVQD      S+  E     P+  L+ + S +S     +  G     HI+EN
Sbjct: 1626 PKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAG---VLHITEN 1682



 Score = 62.8 bits (151), Expect = 7e-09
 Identities = 289/1470 (19%), Positives = 497/1470 (33%), Gaps = 206/1470 (14%)

Query: 2    ASRDSNHAGESFLGSDGDEEATRELETEEESEGEEDETAAESEEEPDSRLSDQDEEGKIK 61
            A  D + A E       +EEA  E + E+  E E +    E+E+   + +    E G  +
Sbjct: 1000 AEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAE 1059

Query: 62   QEYIISDPSFSMVTVQR---------EDSGITWETNSSRSSTPWASEESQTSGVCSREGS 112
            ++Y         +  Q           D  +   + S  +++   + E Q     +  G 
Sbjct: 1060 EQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGY 1119

Query: 113  T-----VNSPPGNVSFIVDEVKKVRKRTHKSKHGSPSLRRKGNRK-RNSFESQDVPTNKK 166
            T     ++S P  +  +      +   T+  +  SPS       K  +S  SQ+      
Sbjct: 1120 TQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD 1179

Query: 167  GSPLTSASQVLTTEKEKSYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLRPVYIGTVQ 226
             +PL   S       E S T   D      + S   P +     +     LR  Y   V+
Sbjct: 1180 VTPLNGFS-------EGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK 1232

Query: 227  YKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRK 286
                +   +K+ +  +                    +  S S  P L  S  + + KT  
Sbjct: 1233 ASTTL--DIKDSISAVS------------------SEKVSPSKSPSLSPSPPSPLEKT-P 1271

Query: 287  LVAQSIEDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKIYAD---SPLNATSALEHTVP 343
            L  +S+       F      +   +E+     S E  +++  +   SP + T  LE   P
Sbjct: 1272 LGERSVN------FSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKT--LEVVSP 1323

Query: 344  SYSSSGRAEQGIQLRHSQSVPQQPEDEAKPH-EVEPPSVTPDTPATMFLRTTKEECELAS 402
            S S +G A             Q P DE   H   E     P  P +      K+E E AS
Sbjct: 1324 SQSVTGSAGH-------TPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERAS 1376

Query: 403  PGTAASENDSSVSP--------SFANEVKKEDVYSAHHSISLEAASPGLAASTQDGLDPD 454
                      S SP             +  E  Y +  S   +A+  G A S  +     
Sbjct: 1377 VSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRG-AESPFEEKSGK 1435

Query: 455  QEQPDLTSIERAEPVSAKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKEEIETSLP 514
            Q  PD  S     PVS     T  S+  +K+E        + E    +E + +++E    
Sbjct: 1436 QGSPDQVS-----PVSEM---TSTSLYQDKQEGKSTDFAPIKEDFG-QEKKTDDVE---- 1482

Query: 515  IAITPEP----EDSNLVEEEIVELDYPESPLVSEKPFPPHMSPEVEHKEEELILPLLAAS 570
             A++ +P    ++  L +    ++D  +     E          V  K    +   +A  
Sbjct: 1483 -AMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED 1541

Query: 571  SPEHVALSEEEREEIASVSTGSAFVSEYSVP--QDLNHELQEQEGEPVPPSNVEAIAEHA 628
            +  H+       E +ASVST S   S +  P   D++  L  + G P      ++++   
Sbjct: 1542 TYSHM-------EGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSV 1594

Query: 629  VLSEEENEEFE-AYSPAAAPTSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASES 687
            V +    +E E + S    P   S   P  + KT+++++P+      ++       + E 
Sbjct: 1595 VQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPV-----QDHRSEQSSMSIEF 1649

Query: 688  GCYTPDSTSASEYSVPS----------LATKESLKKTIDRK-SPLILKGVSEYMIPSEEK 736
            G  +P+ + A ++S  S          L   E+    +D   S +    +S  + P EE 
Sbjct: 1650 GQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP 1709

Query: 737  EDTGS-------------FTPAVAPASEPS--LSPSTTEKTSECQSP----LPSTATSEH 777
              T                +P+ + A  PS   SP   +  S+   P    L ++ TSE 
Sbjct: 1710 SYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEK 1769

Query: 778  VVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLS--- 834
            V   EGE L  +  +  S L  + ++PL +   S     +  S  K K  + H+  S   
Sbjct: 1770 VQSLEGEKLSPK--SDISPLTPRESSPLYSPTFS-----DSTSAVKEKTATCHSSSSPPI 1822

Query: 835  -VDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERY 893
                 E  G  +  L    +H    +    T   +      TP ++       A +    
Sbjct: 1823 DAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDF-----SYAYQKPEE 1877

Query: 894  TPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFS--PDSAF 951
            T  S    ++    Y       +   +    ++  +   + S    E IG  +  P+   
Sbjct: 1878 TTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGD 1937

Query: 952  VSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELF----------SPD 1001
             S +      T+  E+  +  D     TSP E +  S E TE +             S D
Sbjct: 1938 YS-YEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSED 1996

Query: 1002 SASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSS 1061
                +  P +    TEK    P+S        GYS       E    T  TP +  +   
Sbjct: 1997 GGHTLGDPSYSYETTEKITSFPES-------EGYSY------ETSTKTTRTPDTSTYCYE 2043

Query: 1062 QKQKAETFPLMSPL--EDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYL 1119
              +K    P  S    E   L  + +K   +E + ++     S  EY    + + + +++
Sbjct: 2044 TAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKH-PKTELSPSFI 2102

Query: 1120 EPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPA 1179
             P   +   S      E+ E+  + S  A P     Q     +ET P S     P    +
Sbjct: 2103 NPNPLEWFASE--EPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDS 2160

Query: 1180 -IKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVS------QDQKMEPQPPN 1232
             +  E E   ++T  A  +    S+   E I  D      H+       QD+   P+ P+
Sbjct: 2161 DVPPETEECPSITADANID----SEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPD 2216

Query: 1233 VPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSG 1292
            V            MVD     ++  L   +  +L+++  +K      K  SP+K++    
Sbjct: 2217 V-----------SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKS 2265

Query: 1293 PEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKEIEPSSS 1352
                ++ K     +S    + +        VEK  +        +A  EE  KE   + +
Sbjct: 2266 KPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKE---TKN 2322

Query: 1353 TTTASVTKLDSNLTRAVKEEIPTDSSLITP 1382
               AS +K     T        T SS + P
Sbjct: 2323 AANASASKSAKTATAGPGTTKTTKSSAVPP 2352



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 145/762 (19%), Positives = 269/762 (35%), Gaps = 119/762 (15%)

Query: 2786 FPSKESERTLARPFDETKSSETPPYLLSPVKPQTLASGASP----EINAVKKKEMPRSEL 2841
            FP   ++  +    ++ K  +   +L  P+  Q   +G  P    +   +K++   R  L
Sbjct: 489  FPGNSTQYNILEGLEKLKHLD---FLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESL 545

Query: 2842 TPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSA 2901
             P    + +    K+   + P+   +   +H+E       KE +   K    +  +  S 
Sbjct: 546  KPAAKPLPSKSVRKESKEETPE---VTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPS- 601

Query: 2902 SNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQKTAFSIISEGCEILNIHAPAF 2961
                  V+ KE+P + E +  K E              +K A  +  +  +   +     
Sbjct: 602  ------VTEKEVPSKEEPSPVKAE------------VAEKQATDVKPKAAKEKTVKKETK 643

Query: 2962 ISSIDQ-EESEQMQDKLEYLEEKASFKTIPLPDDSET-------VACHKTLKSRLEDEKV 3013
            +   D+ EE E+ + ++   E+K   K    P   E        +   +  + + E +K 
Sbjct: 644  VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKE 703

Query: 3014 TPLKENKQKETHKTKEEISTD-----------------SETDLS------FIQPTIPSEE 3050
            TP KE K++   + K+E+  +                 S T LS       ++P +P +E
Sbjct: 704  TPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKE 763

Query: 3051 DYFEKYTLIDYNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVK 3110
            +  +K ++          K K   K+ V +K  K       +    +  +A+     +  
Sbjct: 764  ESVKKDSVA-------AGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAA 816

Query: 3111 LDESFYGPEKG----HNILSHPETQSQNSADRNVSK-DTKRDVDSKSPGMPLFEAEEGVL 3165
            +     GP K      +++S PE  +++  +    + D  +D+    P + L E EE  L
Sbjct: 817  I-----GPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI---KPQLELIEDEEK-L 867

Query: 3166 SRTQIFPTTIKVIDPEF-LEEPPALAFLYKDLYEEAVGEKKK--EEETASEGDSVNSEAS 3222
              T+  P    VI  E  + + PA +        E  GE ++  EE    E   V+    
Sbjct: 868  KETE--PVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEK 925

Query: 3223 FPSRNSDTDDG--TGIYFEKYILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEG 3280
            F    +  ++   TG Y EK         +T   ++ +  G E   V     + P   E 
Sbjct: 926  FEDEGAGFEESSETGDYEEKA--------ETEEAEEPEEDGEEHVCVSAS-KHSPTEDEE 976

Query: 3281 EIWGKFGTICREKSLEEQKGVYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAV 3340
                +     REK      G     E +D     G     ++    ED     ++  Y  
Sbjct: 977  SAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEP 1036

Query: 3341 P-FEDTHHVLERADEAGSHGNEVGNASPEVN-LNVPVQVSFPEEEFASGATHVQETSLEE 3398
               E   +V+   D+A     E G A  +   L  P +    +      A+ + + +L  
Sbjct: 1037 EKMEAEDYVMAVVDKAA----EAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPG 1092

Query: 3399 PKILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKESF 3458
                      EE   + P  +E+  T       +       E+SSE TP D +S  ++  
Sbjct: 1093 GSESEATASDEENREDQP--EEFTATSGYTQSTI-------EISSEPTPMDEMSTPRDVM 1143

Query: 3459 EHISENEFASEAEQSTPAEQKELGSERKEEDQLSSEVVTEKA 3500
               + NE        T +  +E  +  K E  L S+  ++ A
Sbjct: 1144 SDETNNE-------ETESPSQEFVNITKYESSLYSQEYSKPA 1178


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 83.2 bits (204), Expect = 5e-15
 Identities = 419/2113 (19%), Positives = 728/2113 (34%), Gaps = 392/2113 (18%)

Query: 483   EKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLV 542
             E EE   E  +   +  + EE  + ++   +P    P P    ++++ ++E     S  +
Sbjct: 9139  EWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPP--KVIKKPVIEKIEKTSRRM 9196

Query: 543   SEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEERE-EIASVSTGSAFVSEYSVP 601
              E+       PEV  K        +    P    + EE  E ++ +V T    +SE  + 
Sbjct: 9197  EEEKVQVTKVPEVSKK--------IVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKM- 9247

Query: 602   QDLNHELQEQEGEPVPPSNVEAIAE---HAVLSEEENEEFEAYSPAAAPTSESSLSPSTT 658
                    +E+    VP    E + E   H  +S+      +       P  E  ++P   
Sbjct: 9248  -FFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEE-VAPVPI 9305

Query: 659   EKTSENQSPLFSTV----TPEYM----VLSGDEASESGCYTPDSTSASEYSVPSLATKES 710
              K  E  +P    V     PE      V   + A+             E  +P    K+ 
Sbjct: 9306  PKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKK- 9364

Query: 711   LKKTIDRKSPLILKGV---SEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQS 767
              K+    K P + KGV    +  I ++ +E      P +     P        K  E   
Sbjct: 9365  -KEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPP 9423

Query: 768   PLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGI 827
             P    A  +  VP E   +           ++K A P  A  E  KK + E  +F     
Sbjct: 9424  PPKVPALPKKPVPEEKVAVPVP--------VAKKAPPPRA--EVSKKTVVEEKRFV---- 9469

Query: 828   SEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEA 887
                       +E +  + P  V  + H       E+++E           E+    +EE 
Sbjct: 9470  ---------AEEKLSFAVPQRVEVTRH-------EVSAE----------EEWSYSEEEEG 9503

Query: 888   VELERYTPSSTSASEFS-VPPYATPEAQEEEIVHRSLNL---KGASSPMNLSEEDQEDIG 943
             V +  Y        E + V  Y   E  EE +V   L++   +  + P  ++E  ++ I 
Sbjct: 9504  VSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIV 9563

Query: 944   PFSPDSAFVSEFSFPPYATQEAEKR---EFECDSPICLTSPSEHTILSDEDTEEA----- 995
                   A + E   PP    EA K+   E +  +P+    P +  +   +  EE      
Sbjct: 9564  LKPKIPAKIEEP--PPAKVPEAPKKIVPEKKVPAPV----PKKEKVPPPKVPEEPKKPVP 9617

Query: 996   ELFSPDSASQVSIP-PFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPV 1054
             E   P    ++  P P +++E      + + +L AV+       +   EE         V
Sbjct: 9618  EKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEP-----KRAV 9672

Query: 1055  SEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTS-VSEYLILAQKQ 1113
              E+     K K E  P   P +         K EK  I  E P      + E  I+ +K+
Sbjct: 9673  PEEKVLKLKPKREEEP---PAKVTEFRKRVVKEEKVSI--EAPKREPQPIKEVTIMEEKE 9727

Query: 1114  KTQAYLEPESEDLIPSHLTSEVEK------GEREASSSVAAIPAALPAQSSIVKEE---- 1163
             +    LE E+  +       E E+       E E +            +    +E     
Sbjct: 9728  RAYT-LEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYI 9786

Query: 1164  TKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQD 1223
             T+P  P  V P     + +E  PT       A     L K   EE VP        V   
Sbjct: 9787  TEPEKPIPVKP-----VPEEPVPTKP----KAPPAKVLKKAVPEEKVP--------VPIP 9829

Query: 1224  QKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYS 1283
             +K++P PP VPE             EPKK  + K+ +++T   +++         +KP  
Sbjct: 9830  KKLKPPPPKVPE-------------EPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKR 9876

Query: 1284  -------PLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAF 1336
                    P+    ++ P  +  V  E++ +       +V H     VE++ E+      F
Sbjct: 9877  VVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEF 9936

Query: 1337  SALSE----------EIKKEIEPSSSTTTASVTKLDS------NLTRAVKEEIPTDSSLI 1380
                 E          E+ ++  P          K ++       + +  +E++P    LI
Sbjct: 9937  ITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPV---LI 9993

Query: 1381  TPVDRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAE 1440
                ++P   KV +        P     +E   +    KV    A   E   K +     E
Sbjct: 9994  PKKEKPPPAKVPE-------VPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVP----E 10042

Query: 1441  KEIKFDSLPSVSSIAEHSVLSEVEAK---EVKAGLPV---IKTSSSQHSDKSEEARVE-- 1492
             K++   +   V   A  + + EV  K   E K   PV   ++    +   K E   V   
Sbjct: 10043 KKVPVPAPKKVE--APPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVA 10100

Query: 1493  --DKQDLLFSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNV 1550
                ++++LF      E  V  +++ ++   E + PE E  L    EI  +E E+P  +  
Sbjct: 10101 LPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEY 10160

Query: 1551  SPASKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEK 1610
              P  +  +P   +EE     PE+                   KP V V +      P  K
Sbjct: 10161 VPEEEEFVP---EEEVL---PEV-------------------KPKVPVPAPV----PEIK 10191

Query: 1611  QDVALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLE 1670
             + V   ++ + P+K++ P  P ++P    +               + K  I   E+ VL 
Sbjct: 10192 KKVTEKKVVI-PKKEEAP--PAKVPEVPKKV--------------EEKRIILPKEEEVL- 10233

Query: 1671  KGPAELRSREGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPA 1730
               P E+     +E   E       P+I E+          EE+ P  P++  +  K  P 
Sbjct: 10234 --PVEVTEEPEEEPISEEEIPEEPPSIEEV----------EEVAP--PRVPEVIKKAVPE 10279

Query: 1731  SVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKL 1790
             +        E  P   S K   E+V  P   K+         PP              K+
Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEA--------PPA-------------KV 10318

Query: 1791  SEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLG 1850
              E                P K+    +LV +K         + V      T  E+K  + 
Sbjct: 10319 PEV---------------PKKVPEKKVLVPKK---------EAVPPAKGRTVLEEKVSVA 10354

Query: 1851  IKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKD---ENWMLGKPENVASQHE 1907
              +Q  +++E L LE  ++ +   P + +  ++EE+F   +    E ++  +   V  +H 
Sbjct: 10355 FRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHR 10414

Query: 1908  QRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDT 1967
                   V ++   + E+   +   A        E+ ++++P     + +  ++   A   
Sbjct: 10415 VEKVHRV-IEVFEAEEVEVFEKPKAPPKGP---EISEKIIPPKKPPTKVVPRKEPPA--- 10467

Query: 1968  SSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTE 2027
                    +  K    E+V++ EEP+                ++  ++  + ++ EK    
Sbjct: 10468 ---KVPEVPKKIVVEEKVRVPEEPR------------VPPTKVPEVLPPKEVVPEKKVPV 10512

Query: 2028  LSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEK 2087
                P+K+      K+P       P   + V   K   +  + K    P   V      EK
Sbjct: 10513 P--PAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPT-KVPEVPKAAVP-----EK 10564

Query: 2088  EAHRSTPPFPEEKPLE----ESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREP 2143
             +   + PP PE  P E      ++V  K +  A   K     VK+P   K +        
Sbjct: 10565 KVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPV 10624

Query: 2144  QSPESPEVTQNPPTQ-PKVAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQED- 2201
               P+ PEV   PPT+ P+V K  +PE+K  + I              S P     E E+ 
Sbjct: 10625 PPPKKPEV---PPTKVPEVPKVAVPEKKVPEAIPPKPE---------SPPPEVFEEPEEV 10672

Query: 2202  -LETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVK----LKTADEPRGTLVKS 2256
              LE  P+  VE+      P+ T+P    V EK A   +++      +K  + P+      
Sbjct: 10673 ALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPK------ 10726

Query: 2257  GDGQNVKEKSMILSNVEDLQQPKF-ISEVSREDYGKKEISGDSEEMNINSVVTSADGENL 2315
                + V EK + L   +  + P   + EV +E   +K+++   +     + V        
Sbjct: 10727 ---EVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVP------- 10776

Query: 2316  EIQSYSLIGEK--LVMEEAKTIVPPHVTDSKRVQKPA--IAPPSKWNISIFKEE------ 2365
             E+    ++ EK  + + E     PP V +      P   IAP  +  + + +EE      
Sbjct: 10777 EVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPP 10836

Query: 2366  PRSDQKQKSLLSFDVVD--KVPQQP---KSASSNFASKNITKESEKPESIILPVEESKGS 2420
             P   ++ K ++    V   K P+ P   +        K   K    P     P E+ K  
Sbjct: 10837 PAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEK 10896

Query: 2421  LIDFSEDRLKKEMQNP--------TSLKISEEETKLRSVSPTEKKDNLENRSYTLAEKKV 2472
             +        KK  + P        T LK+   E K+R + P  K +  E        +K 
Sbjct: 10897 IFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKR 10956

Query: 2473  LAEKQNSVAPLEL 2485
               E++  V P +L
Sbjct: 10957 PEEEEPKVEPKKL 10969



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 387/1954 (19%), Positives = 658/1954 (33%), Gaps = 349/1954 (17%)

Query: 456   EQPDLTSIERAEPVSAKLTPTHPSVKGEKEENML-----EPSISLSEPLMLEEPEKEE-I 509
             ++P  T ++  E +  K+   H       EE M      E  +S++ P + +E   EE I
Sbjct: 9216  QKPSRTPVQE-EVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKI 9274

Query: 510   ETSLPIAITPEPEDSNLVE----EEI--------VELDYPESPLVSEKPFP--------- 548
               ++   + P P+   L E    EE+        VE   P+ P V +KP P         
Sbjct: 9275  HVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVP 9334

Query: 549   ------PHMSPEVEHK---EEELILPLLAASSPEHVALSEEER----EEIASVSTGSAFV 595
                   P   PEV  K   EE++ +P+          + E ++    EE  ++ T     
Sbjct: 9335  KKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREES 9394

Query: 596   SEYSVPQDLNHELQEQ-------EGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPT 648
                +VP+    ++ E+       E E  PP  V A+ +  V  E+          A  P 
Sbjct: 9395  PPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPR 9454

Query: 649   SESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDE--ASESGCYTPDSTSAS-------- 698
             +E S      EK    +  L S   P+ + ++  E  A E   Y+ +    S        
Sbjct: 9455  AEVSKKTVVEEKRFVAEEKL-SFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEE 9513

Query: 699   ----------EYSV-----------------------PSLATKESLKKTIDR-KSPLILK 724
                       EY V                       P+  T+   KK + + K P  ++
Sbjct: 9514  REEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIE 9573

Query: 725   GVSEYMIPSEEKEDT-GSFTPAVAPASEPSLSPSTTE-------------KTSECQSPLP 770
                   +P   K+       PA  P  E    P   E             K  + + PLP
Sbjct: 9574  EPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLP 9633

Query: 771   STATSEHVVPSEGEDLGSERFTPDSKLI----SKYAAPLNATQESQKKIINEAS--QFKP 824
             +  T  H+           + T + K++     K A P     E  K+ + E    + KP
Sbjct: 9634  AKVTERHM-----------QITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKP 9682

Query: 825   KGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPP--HTTEMTSECQAPPLS------ATP 876
             K   E      + ++ +       + A +    P    T M  + +A  L          
Sbjct: 9683  KREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQRE 9742

Query: 877   SEYVVLSDEEAVELERYTPSS--TSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNL 934
              EY    + +  E E Y P+       E+    Y   E  EE I      +     P+  
Sbjct: 9743  EEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPI-----PVKP 9797

Query: 935   SEEDQEDIGPFSPDSAFV--------------SEFSFPPYATQEAEKREFECDSPICLTS 980
               E+     P +P +  +               +   PP    E  K+ FE    I +T 
Sbjct: 9798  VPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITK 9857

Query: 981   PSEHTILS-------DEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLL--TAVS 1031
               +  +               AE   P    +V+ PP R+ E  K ELEP+ +     V 
Sbjct: 9858  REKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVA-PPVRVPEVPK-ELEPEEVAFEEEVV 9915

Query: 1032  ASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAE 1091
                     E +EE I         E+       K    P     E+    P   K E   
Sbjct: 9916  THVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPP 9975

Query: 1092  IK-PEIPTTSTSVSEYLILAQKQKTQAYL-----EPESEDLIPSHLTSEVE--------- 1136
              K PE+P         LI  +++   A +     +P  E+ +P  +  +VE         
Sbjct: 9976  AKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEV 10035

Query: 1137  --------KGEREASSSVAAIPAALP-AQSSIVKEETKPASPHSVLPDSVPAIKKEQEPT 1187
                     K    A   V A PA +P     ++ EE KP      +    P + K++EP 
Sbjct: 10036 PKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPV 10095

Query: 1188  AALTLKAADEQMALSK--VRKEEIVPDSQEATAH----VSQDQKMEPQPPNVPESEMKYS 1241
                     +E++   +  V +EE++P+ +E        + +++++ P+   +P  E +  
Sbjct: 10096 PVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVP 10155

Query: 1242  VLPDMVDE-----PKKGVKP--KLVLNVTSELEQRKLSKNEPEVIKPYS----PLKETSL 1290
                + V E     P++ V P  K  + V + + + K    E +V+ P      P K   +
Sbjct: 10156 PEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEV 10215

Query: 1291  SGPEALSAVKMEMKHDSKITTTPIVLHSASSGV-EKQVEHGPPAL------AFSALSEEI 1343
               P+ +   ++ +  + ++    +        + E+++   PP++      A   + E I
Sbjct: 10216 --PKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVI 10273

Query: 1344  KKEIEPSSSTTTASVTKLDSNLTRAVKEE---IPTDSSLITPVDRP-VLTKVGKGELGSG 1399
             KK +  + +     V    + +++ + EE   +P       P   P V  KV + ++   
Sbjct: 10274 KKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVP 10333

Query: 1400  LPPLVTSADEHSVLAEEDKVAIKGASPI-ETSSKHLAWSEAEKEIKFDSLPSVSSIAEHS 1458
                 V  A   +VL E+  VA +    + E     +  +E E+  + +    V    E  
Sbjct: 10334 KKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEG 10393

Query: 1459  VLSEV------EAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSSQ 1512
                EV      E   V+    V K        ++EE  V +K          SE+++   
Sbjct: 10394 EFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKII-PP 10452

Query: 1513  KKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPAS-------KHIIPKGK--- 1562
             KK         EP  ++P      + +++  +P    V P         K ++P+ K   
Sbjct: 10453 KKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPV 10512

Query: 1563  --DEETASSSPELENLASGLAPTLLLLSDDKNKPAV---EVSSTAQGDFPSEKQDVALAE 1617
                ++  +  P++      + P   +      KP V   +V    +   P +K   A+  
Sbjct: 10513 PPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAI-- 10570

Query: 1618  LSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELR 1677
                 P K + P  P E+P A                    K  + E +         E+ 
Sbjct: 10571 ----PPKPESP--PPEVPEA-------------------PKEVVPEKKVPAAPPKKPEVT 10605

Query: 1678  SREGKEENRELCASSTMPAISELSSLLREESQNEEIKPFS----PKIISLESKEPPA--S 1731
               +  E  +E+     +P             +  E+ P      PK+   E K P A   
Sbjct: 10606 PVKVPEAPKEVVPEKKVPV---------PPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPP 10656

Query: 1732  VAEGGNPEEF-QPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKL 1790
               E   PE F +P   +L+    EV    +        + P  P    KA  +     +L
Sbjct: 10657 KPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPEL 10716

Query: 1791  SEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLG 1850
                   P     +     P K  P   LV  KK E         K+P+V      ++ + 
Sbjct: 10717 P-----PVKVPEVPKEVVPEKKVP---LVVPKKPEA-----PPAKVPEVPKEVVPEKKVA 10763

Query: 1851  I-KQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQR 1909
             + K+  +    +P    K  +  KPA     + E    SP  E  +  +PE +A +    
Sbjct: 10764 VPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAE----SPPPE--VYEEPEEIAPE---- 10813

Query: 1910  IAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSS 1969
                          E+ P + K    +++   EV    +P   E   +  ++ V  +    
Sbjct: 10814 ------------EEIAPEEEKPVPVAEEEEPEVPPPAVPE--EPKKIIPEKKVPVIKKPE 10859

Query: 1970  GNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELS 2029
                          E+ KL   P     A   E               E +   KA  +  
Sbjct: 10860 APPPKEPEPEKVIEKPKLKPRPPPPPPAPPKED------------VKEKIFQLKAIPKKK 10907

Query: 2030  WPSKEDSQEKIKLPPERF--FQKPVSGLSVE---QVKSETISSSVKTAHFPAEGVEPALG 2084
              P K    EK++L P +    +K V  L  E   + K E +  SV       E  EP + 
Sbjct: 10908 VPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKR--PEEEEPKVE 10965

Query: 2085  NEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQ 2144
              +K      P  PE  P +  + V+   +    E K P P  K+P + KP   + A EP+
Sbjct: 10966 PKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKR-ERKIPEP-TKVP-EIKPAIPLPAPEPK 11022

Query: 2145  SPESPEV--TQNPPTQPK---VAKPDLPEEKGKK 2173
                  EV   + PP +P+   +A P      GKK
Sbjct: 11023 PKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKK 11056



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 199/951 (20%), Positives = 318/951 (33%), Gaps = 147/951 (15%)

Query: 480   VKGEKEENMLEPSISLSEPLMLEEPEK-------EEIETSLPIAITPEPEDSNL----VE 528
             V  E EE  +       EP  +EE E+       E I+ ++P A TP P+        V 
Sbjct: 10237 VTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVS 10296

Query: 529   EEIVELDYPESPLVSEKPFPPHMSPEVEHK--EEELILPLLAASSPEHVALSEEEREEIA 586
             ++I E   P    V +K  PP   PEV  K  E+++++P   A  P       EE+  +A
Sbjct: 10297 KKIPEEKVPVP--VQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVA 10354

Query: 587   SVSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSN----VEAIAE---------------- 626
                    F  E  V + L  E+ E E E +P       VE   E                
Sbjct: 10355 -------FRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQH 10407

Query: 627   -----------HAVLSEEENEEFEAYSPAAAPT-----SESSLSPST--TEKTSENQSPL 668
                        H V+   E EE E +    AP      SE  + P    T+     + P 
Sbjct: 10408 RVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPA 10467

Query: 669   FSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPS-LATKESLKKTIDRKSPLILKGVS 727
                  P+ +V+      E     P+        VP  L  KE + +      P       
Sbjct: 10468 KVPEVPKKIVV------EEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAP 10521

Query: 728   EYMIPSEEKEDTGSFTPAVAPASEPSLSPSTT----------EKTSECQSPLPSTATSEH 777
                +P   KE        V P  +P + P+            +K  E   P P +   E 
Sbjct: 10522 PPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPE- 10580

Query: 778   VVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEAS---------QFKPKGIS 828
              VP   +++  E+  P +        P+    E+ K+++ E           +  P  + 
Sbjct: 10581 -VPEAPKEVVPEKKVPAAPPKKPEVTPVKVP-EAPKEVVPEKKVPVPPPKKPEVPPTKVP 10638

Query: 829   EHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSEC--QAPPLSATPSEYVVLSDEE 886
             E   ++V  K+V     P+ +     S PP   E   E   + PP             + 
Sbjct: 10639 EVPKVAVPEKKV-----PEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQV 10693

Query: 887   AVELERYTPSSTS----ASEFSVPPYATPEAQEEEIVHRSLNL----KGASSPMNLSEED 938
              V  ++  P   +    A +  +PP   PE  +E +  + + L    K  + P  + E  
Sbjct: 10694 TVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVP 10753

Query: 939   QEDIGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELF 998
             +E +       A   +   PP    E  K+    + P  +  P        E  EE E  
Sbjct: 10754 KEVVP--EKKVAVPKKPEVPPAKVPEVPKKPVLEEKP-AVPVPERAESPPPEVYEEPEEI 10810

Query: 999   SPDSA-SQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQ 1057
             +P+   +     P  ++E E+ E+ P     AV         E     I    A P  E 
Sbjct: 10811 APEEEIAPEEEKPVPVAEEEEPEVPPP----AVPEEPKKIIPEKKVPVIKKPEAPPPKEP 10866

Query: 1058  FSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQA 1117
                   +K +  P   P      PP  D  EK      IP             +K+  + 
Sbjct: 10867 EPEKVIEKPKLKPRPPPPPPA--PPKEDVKEKIFQLKAIP-------------KKKVPEK 10911

Query: 1118  YLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSV 1177
                PE  +L P  +    EK  R+        P       S++++  +   P  V P  +
Sbjct: 10912 PQVPEKVELTPLKVPGG-EKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEP-KVEPKKL 10969

Query: 1178  PAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESE 1237
               +KK   P      K  +E    +  ++E  +P+  +            P+P   PE+E
Sbjct: 10970 EKVKKPAVPEPPPP-KPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAE 11028

Query: 1238  MKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALS 1297
             +K    P +  EP     P  V  V  + E +     + E  KP  P+K      P  + 
Sbjct: 11029 VKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAK---APKEEAAKPKGPIKGVPKKTPSPIE 11085

Query: 1298  AVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKEIE 1348
             A + +++                SG EK  +  P      A+  +  KEI+
Sbjct: 11086 AERRKLR--------------PGSGGEKPPDEAPFTYQLKAVPLKFVKEIK 11122



 Score = 76.3 bits (186), Expect = 6e-13
 Identities = 292/1443 (20%), Positives = 493/1443 (34%), Gaps = 315/1443 (21%)

Query: 468   PVSAKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLV 527
             P+  KL P  P V  E+ + + E  I +S    + + EKE++    P A  P      + 
Sbjct: 9827  PIPKKLKPPPPKVP-EEPKKVFEEKIRIS----ITKREKEQVTE--PAAKVPMKPKRVVA 9879

Query: 528   EEEIVELDYPESPLVSEKPFPPHMSPEVEHKEEELILPL---LAASSPEHVALSEE---E 581
             EE++       +P V     P  + PE    EEE++  +   L     E++   EE   E
Sbjct: 9880  EEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITE 9939

Query: 582   REEIASVSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAY 641
              E +  +      V    VP       +E++  PVP       A+   + ++  E+    
Sbjct: 9940  EEVVPVIPVKVPEVPRKPVP-------EEKKPVPVPKKKEAPPAKVPEVPKKPEEKV--- 9989

Query: 642   SPAAAPTSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYS 701
              P   P  E    P+   +  +   P      P                 P    A    
Sbjct: 9990  -PVLIPKKEKP-PPAKVPEVPKKPVPEEKVPVP----------------VPKKVEAPPAK 10031

Query: 702   VPSLATKESLKKTIDRKSPLILKG-------VSEYMIPSEEKEDTGSFTPAVAPASEPSL 754
             VP +  K   +K +   +P  ++        V + +IP E+K       P   P    + 
Sbjct: 10032 VPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKK-------PTPVPKKVEAP 10084

Query: 755   SPSTTEKTSECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQE---S 811
              P   +K      P+         +P E E L  E   P+ +++ +    L   +E    
Sbjct: 10085 PPKVPKKREPVPVPV--------ALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPE 10136

Query: 812   QKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPP 871
             +++++ E  +  P+            +E + P   +  V  E  F P    +       P
Sbjct: 10137 EEEVLPEEEEIPPE------------EEEVPPE--EEYVPEEEEFVPEEEVLPEVKPKVP 10182

Query: 872   LSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSP 931
             + A   E      ++  E +   P    A    VP    P+  EE+ +   L  +    P
Sbjct: 10183 VPAPVPEI----KKKVTEKKVVIPKKEEAPPAKVP--EVPKKVEEKRI--ILPKEEEVLP 10234

Query: 932   MNLSEEDQ-----EDIGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTI 986
             + ++EE +     E+  P  P S    E   PP   +  +K   E  +P+     +    
Sbjct: 10235 VEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAK 10294

Query: 987   LSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLL----TAVSASGYSCFS--- 1039
             +S +  EE     P    +   PP ++ E  K   E   L+        A G +      
Sbjct: 10295 VSKKIPEEK---VPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKV 10351

Query: 1040  -------------------EADEEDIGSTAA-TPVSEQFSSSQKQKAETFPLMSP----- 1074
                                EA+ E+I        V E F   +  + E F  +       
Sbjct: 10352 SVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEE 10411

Query: 1075  ---LEDLSLPPSTDKSEKAEI--KPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIP- 1128
                +E +       ++E+ E+  KP+ P     +SE +I  +K  T+     E    +P 
Sbjct: 10412 EHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPE 10471

Query: 1129  ---SHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETK--------------PASPHS 1171
                  +  E  +   E       +P  LP +  + +++                P +P  
Sbjct: 10472 VPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKE 10531

Query: 1172  VLPD-----------SVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHV 1220
             V+P+            VP  K  + P AA+  K   E +     + E   P+  EA   V
Sbjct: 10532 VVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAI---PPKPESPPPEVPEAPKEV 10588

Query: 1221  SQDQKMEPQPPNVPE-SEMKYSVLP-DMVDEPKKGVKP--KLVLNVTSELEQRKLS---K 1273
               ++K+   PP  PE + +K    P ++V E K  V P  K  +  T   E  K++   K
Sbjct: 10589 VPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEK 10648

Query: 1274  NEPEVI--KPYSP-------LKETSLSGPEALSAVKMEMKHDSKITT---TPIVLHSASS 1321
               PE I  KP SP        +E +L  P A    + E     ++T     P+    A +
Sbjct: 10649 KVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPA 10708

Query: 1322  GVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRA--VKEEIPTDSSL 1379
              V K+ E  P  +       E+ KE+ P          K ++   +   V +E+  +  +
Sbjct: 10709 VVAKKPELPPVKV------PEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKV 10762

Query: 1380  ITP-------------VDRPVLTK---VGKGELGSGLPPLVTSADEHSVLAEEDKVAIKG 1423
               P               +PVL +   V   E     PP V   +E   +A E+++A + 
Sbjct: 10763 AVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEV--YEEPEEIAPEEEIAPEE 10820

Query: 1424  ASPIETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEVEAKEV--KAGLPVIKTSSSQ 1481
               P+  +       E E E+   ++P              E K++  +  +PVIK   + 
Sbjct: 10821 EKPVPVA------EEEEPEVPPPAVPE-------------EPKKIIPEKKVPVIKKPEAP 10861

Query: 1482  HSDKSEEARV-------------------EDKQDLLFSTVCDSERLVSSQKKSLMSTSEV 1522
                + E  +V                   ED ++ +F       +L +  KK +    +V
Sbjct: 10862 PPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIF-------QLKAIPKKKVPEKPQV 10914

Query: 1523  LEPEHELPLSLWGEIKKKETELPSSQ---NVSPASKHIIPKGKDEETASSSP-ELENLAS 1578
              E     PL + G  KK    LP  +         K ++ K  +EE     P +LE +  
Sbjct: 10915 PEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKK 10974

Query: 1579  GLAPTLLLLSDDKNKPAVEVSSTAQGDFPS-EKQDVALAELSLEPEKKDKPHQPLELPNA 1637
                P          KP  EV      + P+  K++  + E +  PE   KP  PL  P  
Sbjct: 10975 PAVP-----EPPPPKPVEEV------EVPTVTKRERKIPEPTKVPE--IKPAIPLPAPE- 11020

Query: 1638  GSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRELCASSTMPAI 1697
                                   P  E E   ++  P E        E   + A  T+P +
Sbjct: 11021 --------------------PKPKPEAEVKTIKPPPVE-------PEPTPIAAPVTVPVV 11053

Query: 1698  SELSSLLREESQNEEIKPFSPKIISLESKEPPASVAE---------GGNPEEFQPFTFSL 1748
              + +    +  + E  KP  P I  +  K P    AE         G  P +  PFT+ L
Sbjct: 11054 GKKAE--AKAPKEEAAKPKGP-IKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQL 11110

Query: 1749  KGL 1751
             K +
Sbjct: 11111 KAV 11113



 Score = 72.4 bits (176), Expect = 9e-12
 Identities = 324/1564 (20%), Positives = 560/1564 (35%), Gaps = 250/1564 (15%)

Query: 1941  EVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNV 2000
             EV K+++P   + S    QE V  +   + +T+ +             EE  S+ +   V
Sbjct: 9208  EVSKKIVPQ--KPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVP-EV 9264

Query: 2001  ERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQV 2060
             ++ I   ++IH  +      +E        P K   +E   +P  +  + P     V +V
Sbjct: 9265  QKEIVTEEKIHVAISKR---VEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAP--KVPEV 9319

Query: 2061  KSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEK---PLEESKMVQSKVIDDAD 2117
               + +    K    P +  EPA    K       P PEEK   P+ + K      + +  
Sbjct: 9320  PKKPVPEEKKPVPVPKK--EPA-APPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQ 9376

Query: 2118  EGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISS 2177
             +G     ++ I TQR+             ESP     PP  P++ K  +PEE+       
Sbjct: 9377  KGVVTEEKITIVTQRE-------------ESP-----PPAVPEIPKKKVPEER------- 9411

Query: 2178  FKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHS 2237
                              K   +++ E  P P V        PE  +     VA+K A   
Sbjct: 9412  -----------------KPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKK-APPP 9453

Query: 2238  LSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSREDYGKKEISGD 2297
              +EV  KT                V+EK  +         P+ +     E   ++E S  
Sbjct: 9454  RAEVSKKTV---------------VEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYS 9498

Query: 2298  SEEMNINSVV----TSADGENLEIQSYSLIGE--KLVMEEAKTIVPPHVTDSKRVQKPAI 2351
              EE  ++  V       + E  E+  Y ++ E  + V+EE   I+      SKRV+    
Sbjct: 9499  EEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHII------SKRVE---- 9548

Query: 2352  APPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESII 2411
             A P+         E    Q++K +L   +  K+ ++P  A    A K I  E + P  + 
Sbjct: 9549  AEPA---------EVTERQEKKIVLKPKIPAKI-EEPPPAKVPEAPKKIVPEKKVPAPV- 9597

Query: 2412  LPVEESKGSLIDFSEDRLKKEMQNPT-SLKISEEETKLRSVSPTEKKDNLENRSYTLAEK 2470
              P +E           ++ +E + P    K+  +  K+    P +     E       E+
Sbjct: 9598  -PKKEK------VPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVT---ERHMQITQEE 9647

Query: 2471  KVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHF--YQNEDYNERPK 2528
             KVL       AP + R   E    +     +  +LK  + +  P     ++     E   
Sbjct: 9648  KVLVAVTKKEAPPKARVPEE--PKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKV 9705

Query: 2529  IIVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSL 2588
              I   ++E    KE  +    E     E +  SV   E      +    +   E + +  
Sbjct: 9706  SIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEE----YDYKEFEEYEP 9761

Query: 2589  VKATSVTEKSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIEN 2648
              +     E+ E    E + E  E      +P P++        TK   P A   +  +  
Sbjct: 9762  TEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPE 9821

Query: 2649  HSLSQEGNLVLEKSSRDMPDHSEEKEQFRES---ELSKGGSVDITKETVKQGFQEKAVGT 2705
               +       L+     +P+  E K+ F E     ++K     +T+   K   + K V  
Sbjct: 9822  EKVPVPIPKKLKPPPPKVPE--EPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRV-- 9877

Query: 2706  QPRPLEESKVLVEKTKTFLPV-VLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQF 2764
                 + E KV V + +   PV V     E+E   ++ E  +V       +    EE+E  
Sbjct: 9878  ----VAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLV---EEEEEYI 9930

Query: 2765  KESELWKGGSVDITKESMKEGFPSKESERTLA------RPFDETKSSETPPYLLS--PVK 2816
              E E +      IT+E +    P K  E          +P    K  E PP  +   P K
Sbjct: 9931  HEEEEF------ITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKK 9984

Query: 2817  PQTLASGASPEINA---VKKKEMPRSELTPERHTVHT---IQTSKDDTSDVPKQSVLVSK 2870
             P+       P+       K  E+P+  +  E+  V     ++       +VPK+ V   K
Sbjct: 9985  PEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKK 10044

Query: 2871  HHLEAAEDTRVKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVT 2930
               + A +  +V+ P +       + I                 PK P+    K E   V 
Sbjct: 10045 VPVPAPK--KVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPK----KREPVPV- 10097

Query: 2931  SKPAGLSEDQKTAFS--IISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKT 2988
               P  L ++++  F   I+ E  E+L             EE E + ++ E L E+     
Sbjct: 10098 --PVALPQEEEVLFEEEIVPEE-EVL------------PEEEEVLPEEEEVLPEEEEV-- 10140

Query: 2989  IPLPDDSETVACHKTLKSRLEDEKVTPLKEN-KQKETHKTKEEISTDSETDLSFIQPTIP 3047
               LP++ E            E+E+V P +E   ++E    +EE+  + +  +    P   
Sbjct: 10141 --LPEEEEIPP---------EEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPE 10189

Query: 3048  SEEDYFEKYTLIDYNISPDPEK-QKAPQKLNV--------EEKLSKEVTEETISFPVSSV 3098
              ++   EK  +I       P K  + P+K+          EE L  EVTEE    P+S  
Sbjct: 10190 IKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISE- 10248

Query: 3099  ESALEHEYDLVKLDESFYGPEKGHNILSHPETQSQNSADRNV----SKDTKRDVDSKSPG 3154
             E   E    + +++E    P +   ++     ++     + V    +K +K+  + K P 
Sbjct: 10249 EEIPEEPPSIEEVEE--VAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVP- 10305

Query: 3155  MPLFEAEEGVLSRTQIFPTTI---KVIDPEFLEEPPALAFLYKDLYEEAVGEKKKEEETA 3211
             +P+ + +E   ++    P  +   KV+ P+    PPA     + + EE V    ++E   
Sbjct: 10306 VPV-QKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKG---RTVLEEKVSVAFRQEVVV 10361

Query: 3212  SEG---DSVNSEASFPSRNSDTDDGTGIYFEKYILKDDILHDTSLTQKDQGQGLEEKRVG 3268
              E    + V +E        +  +      E+Y  + +        + +Q +  EE RV 
Sbjct: 10362 KERLELEVVEAEVEEIPEEEEFHE-----VEEYFEEGEFHEVEEFIKLEQHRVEEEHRVE 10416

Query: 3269  KDDSYQPI--AAEGEIWGK-----FGTICREKSLEEQK---GVYGEGESVDHV-ETVGNV 3317
             K      +  A E E++ K      G    EK +  +K    V    E    V E    +
Sbjct: 10417 KVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKI 10476

Query: 3318  AMQKKAPITEDVRVATQKISYAVPFEDTHHVLER------ADEAGSHGNEVGNASPEVNL 3371
              +++K  + E+ RV   K+   +P ++   V E+      A +  +   +V  A  EV  
Sbjct: 10477 VVEEKVRVPEEPRVPPTKVPEVLPPKEV--VPEKKVPVPPAKKPEAPPPKVPEAPKEVVP 10534

Query: 3372  NVPVQVSFPEEEFASGATHVQETSLEE-PKILVPPEPSEERLRNSPVQDEYEFTESLHNE 3430
                V V  P++        V  T + E PK  VP +   E +   P     E  E+   E
Sbjct: 10535 EKKVPVPPPKK------PEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEA-PKE 10587

Query: 3431  VVPQ 3434
             VVP+
Sbjct: 10588 VVPE 10591



 Score = 45.8 bits (107), Expect = 9e-04
 Identities = 187/1025 (18%), Positives = 374/1025 (36%), Gaps = 168/1025 (16%)

Query: 1878  KETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKD 1937
             +E ++ E+ +  + E +++ +  ++ S+  +     V         L+P ++ A +    
Sbjct: 9518  EEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKP-KIPAKIEEPP 9576

Query: 1938  --HTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLV 1995
                  E  K+++P     + +  +E V          + +  K    + +K+ EEP    
Sbjct: 9577  PAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKM-EEPLPAK 9635

Query: 1996  LAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKI-KLPPERFFQKP--V 2052
             +     +   E K + ++ + E+    +   E   P +   +EK+ KL P+R  + P  V
Sbjct: 9636  VTERHMQITQEEKVLVAVTKKEAPPKARVPEE---PKRAVPEEKVLKLKPKREEEPPAKV 9692

Query: 2053  SGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEA----HRSTPPFPEEKPLEESKMV 2108
             +      VK E +S        P    E  +  EKE              E+  EE +  
Sbjct: 9693  TEFRKRVVKEEKVSIEAPKRE-PQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEY 9751

Query: 2109  QSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPE 2168
               K  ++ +  ++     +   +       H      PE P   +  P +P   KP  P 
Sbjct: 9752  DYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPP 9811

Query: 2169  EKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFN 2228
              K  K                + P+ KV      + +P P                    
Sbjct: 9812  AKVLK---------------KAVPEEKVPVPIPKKLKPPPP------------------K 9838

Query: 2229  VAEKPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNV-----EDLQQPKFISE 2283
             V E+P      ++++      +  + +      +K K ++         +++  P  + E
Sbjct: 9839  VPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPE 9898

Query: 2284  VSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEK--LVMEEAKTIVPPHVT 2341
             V +E    +E++ + E      VVT  +   +E +   +  E+  +  EE   ++P  V 
Sbjct: 9899  VPKE-LEPEEVAFEEE------VVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVP 9951

Query: 2342  DSKR-----------VQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKS 2390
             +  R           V K   APP+K       E P+  +++  +L    + K  ++P  
Sbjct: 9952  EVPRKPVPEEKKPVPVPKKKEAPPAK-----VPEVPKKPEEKVPVL----IPK-KEKPPP 10001

Query: 2391  ASSNFASKNITKESEKPESIILPVEESKGSLIDFSEDRL-KKEMQNPTSLKISEEETKL- 2448
             A      K    E + P  +   VE     + +  +  + +K++  P   K+     K+ 
Sbjct: 10002 AKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVP 10061

Query: 2449  ---RSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTEL 2505
                + + P EKK     +       KV  +++    P+ L    E+   +  +     E+
Sbjct: 10062 EVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEE--EV 10119

Query: 2506  KESKADAMPQHFYQNEDYNERPKIIVGSEKEKGEEKE---NQVYVLSEGKKQQEHQPYSV 2562
                + + +P+   + E   E  +++   E+   EE+E    + YV     +++E  P   
Sbjct: 10120 LPEEEEVLPE---EEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYV----PEEEEFVPEEE 10172

Query: 2563  NVAESMSRESDISLGHSLGETQSFSLVKATSVTEKSEAMLAEAHPEIREAKAVGTQPHPL 2622
              + E   +   + +   + E +     K   + +K EA  A+  PE+         P  +
Sbjct: 10173 VLPEVKPK---VPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKV-PEV---------PKKV 10219

Query: 2623  EESKVLVEKTKTFLPVALSCRDEIENHSLSQEG-------------------NLVLEKSS 2663
             EE ++++ K +  LPV ++  +E E   +S+E                      V++K+ 
Sbjct: 10220 EEKRIILPKEEEVLPVEVT--EEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAV 10277

Query: 2664  RDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEK-----AVGTQPRPLEESKVLVE 2718
              + P    +K +   +++SK     I +E V    Q+K      V   P+ + E KVLV 
Sbjct: 10278 PEAPTPVPKKVEAPPAKVSK----KIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVP 10333

Query: 2719  KTKTFLPVV-LSCHDEIENHSLSQE----GNLVLEKSSRDMPDHSEEKEQFKESELWKGG 2773
             K +   P    +  +E  + +  QE      L LE    ++ +  EE+E  +  E ++ G
Sbjct: 10334 KKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEG 10393

Query: 2774  SVDITKESMK-------------------EGFPSKESERTLARPFDETKSSETPPYLLSP 2814
                  +E +K                   E F ++E E    +P    K  E    ++ P
Sbjct: 10394 EFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVE-VFEKPKAPPKGPEISEKIIPP 10452

Query: 2815  VKPQT 2819
              KP T
Sbjct: 10453 KKPPT 10457



 Score = 42.0 bits (97), Expect = 0.012
 Identities = 53/213 (24%), Positives = 87/213 (40%), Gaps = 19/213 (8%)

Query: 3704  VPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTV 3763
             VP PP   P E ++ ++    + W+   ED     + Y +E+ +  + +  +V E    +
Sbjct: 20472 VPGPPG--PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSE---DI 20526

Query: 3764  KESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSE----RAIFRTAPSTPVIRAEDCTVCWN 3819
             +    +   L     Y   V AVN  G   P +    + + R  P  P  + E   V  N
Sbjct: 20527 QSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKN 20586

Query: 3820  TATIRW-RPTTPEATETYTLEYCRQHSPEGEGLRSF-SGIKGLQLKV-NLQPNDNYFFYV 3876
             TAT+ W RP     +E       R+       +R+  + +  L+ KV  LQ    Y F V
Sbjct: 20587 TATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRV 20646

Query: 3877  RAINAFGTSEQSEAALISTRGTRFLLLRETAHP 3909
              A N  G    SEA       +  +L+++ A+P
Sbjct: 20647 SAENRAGIGPPSEA-------SDSVLMKDAAYP 20672



 Score = 42.0 bits (97), Expect = 0.012
 Identities = 46/205 (22%), Positives = 80/205 (39%), Gaps = 13/205 (6%)

Query: 3695  SDQMLKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNE 3754
             SD ++ Q+    P      EP++ T  +I + W+  + D     Q Y +E  ++ +    
Sbjct: 28140 SDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILER-REKKSTRW 28198

Query: 3755  LVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPS--ERAIFRTAPSTP----- 3807
             +    +  + E+      L     Y+  VMA N  G    S   R I    P  P     
Sbjct: 28199 VKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPT 28258

Query: 3808  VIRAEDCTVCWNTATIRW-RPTTPEATET--YTLEYCRQHSPEGEGLRSFSGIKGLQLKV 3864
             V++  D +    T ++ W +P      E   Y +E C+    +   + + + +K      
Sbjct: 28259 VVKVTDTSK--TTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVT 28316

Query: 3865  NLQPNDNYFFYVRAINAFGTSEQSE 3889
             +LQ  + Y F V AIN  G  +  E
Sbjct: 28317 DLQAGEEYKFRVSAINGAGKGDSCE 28341



 Score = 40.8 bits (94), Expect = 0.028
 Identities = 50/195 (25%), Positives = 78/195 (40%), Gaps = 17/195 (8%)

Query: 3705  PQPP-RLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTV 3763
             P PP RLEP +    T   + + W    +D       Y +E    D + ++ V   ++ V
Sbjct: 13883 PGPPTRLEPSD---ITKDAVTLTWCEPDDDGGSPITGYWVERL--DPDTDKWVRCNKMPV 13937

Query: 3764  KESYCIFEDLEPDRCYQVWVMAVNFTGCSLPS---ERAIFRTAPSTPVIRAEDCTVCWNT 3820
             K++    + L   + Y+  V+A N  G   PS   E  + +     P    +        
Sbjct: 13938 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 13997

Query: 3821  ATIRWRPTTPE-----ATETYTLEYCRQHSPEGEGLRSFSGIKGLQ-LKVNLQPNDNYFF 3874
              ++R   T PE       E+Y +E  +  + E   +R   G+   Q L   L     Y F
Sbjct: 13998 TSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW--VRVAEGVPTTQHLLPGLMEGQEYSF 14055

Query: 3875  YVRAINAFGTSEQSE 3889
              VRA+N  G SE SE
Sbjct: 14056 RVRAVNKAGESEPSE 14070



 Score = 40.0 bits (92), Expect = 0.047
 Identities = 96/411 (23%), Positives = 146/411 (35%), Gaps = 73/411 (17%)

Query: 363   VPQQPEDEAKPHEVE-PPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANE 421
             VP+ P++     +V  PP   P+ P T      K          A      S  P    E
Sbjct: 10525 VPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVP-E 10583

Query: 422   VKKEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEP----VSAKLTPTH 477
               KE V        + AA P              ++P++T ++  E     V  K  P  
Sbjct: 10584 APKEVVPEK----KVPAAPP--------------KKPEVTPVKVPEAPKEVVPEKKVPVP 10625

Query: 478   PSVKGEKEENMLEPSISLSEPLMLEEPEKEEIET------SLPIAITPEPEDSNLVE--E 529
             P  K E       P   + E   +  PEK+  E       S P  +  EPE+  L E   
Sbjct: 10626 PPKKPEV------PPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPA 10679

Query: 530   EIVELDYPESP----LVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEI 585
             E+VE   P +P    +  +KP P   +P V  K+ EL  P+     P+ V + E++   +
Sbjct: 10680 EVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPEL-PPVKVPEVPKEV-VPEKKVPLV 10737

Query: 586   ASVSTGSAFVSEYSVPQDL--NHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSP 643
                   +       VP+++    ++   +   VPP+ V  + +  VL E+         P
Sbjct: 10738 VPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEK---------P 10788

Query: 644   AA-APTSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSV 702
             A   P    S  P   E+  E        + PE  +   +E               E  V
Sbjct: 10789 AVPVPERAESPPPEVYEEPEE--------IAPEEEIAPEEEK------PVPVAEEEEPEV 10834

Query: 703   PSLATKESLKKTI-DRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPASEP 752
             P  A  E  KK I ++K P+I K   E   P E + +     P + P   P
Sbjct: 10835 PPPAVPEEPKKIIPEKKVPVIKK--PEAPPPKEPEPEKVIEKPKLKPRPPP 10883



 Score = 39.7 bits (91), Expect = 0.062
 Identities = 59/258 (22%), Positives = 102/258 (39%), Gaps = 19/258 (7%)

Query: 3645  EAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVA- 3703
             E  E    V+    E + E +++  +     E +    ++ ++       SD ++ + A 
Sbjct: 27004 EKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAF 27063

Query: 3704  -VPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLT 3762
               P PP +   E    T  ++ V WS    D       Y +E+   D++     +  + T
Sbjct: 27064 VTPGPPGIP--EVTKITKNSMTVVWSRPIADGGSDISGYFLEKR--DKKSLGWFKVLKET 27119

Query: 3763  VKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTA------PSTPV-IRAEDCT 3815
             ++++      L  +  YQ  V AVN  G    SE + F  A      P  P  IR  D T
Sbjct: 27120 IRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADST 27179

Query: 3816  VCWNTATIRWRPTTPE---ATETYTLEYCRQHSPEGEGLRSFSGIKGLQLKV-NLQPNDN 3871
                ++ T+ W     +   A   Y +E  +    E   + +   ++  +  V NL+P  N
Sbjct: 27180 K--SSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVN 27237

Query: 3872  YFFYVRAINAFGTSEQSE 3889
             Y+F V A+N  G  E  E
Sbjct: 27238 YYFRVSAVNCAGQGEPIE 27255



 Score = 38.1 bits (87), Expect = 0.18
 Identities = 47/173 (27%), Positives = 68/173 (39%), Gaps = 22/173 (12%)

Query: 3779  YQVWVMAVNFTGCSLPSERAIFRTA--PSTPVIRAEDCTVCWNTATIRWRPTTPEATET- 3835
             YQ  V A N  G S PS+ + F  A  P  P    +   V   T T++W P   +     
Sbjct: 27827 YQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKI 27886

Query: 3836  --YTLEYCRQHSPEGEGLRSFSGIKGLQLKVN-LQPNDNYFFYVRAINAFGT--SEQSEA 3890
               Y++E  ++   E     +F+ +   Q  V  L P D Y F + A NA GT       +
Sbjct: 27887 VGYSIE--KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSS 27944

Query: 3891  ALISTRGTRFLLLRETAHPALHISS---SGTVISFGERRRLTEIPSVLGEELP 3940
              +I TR        E   P +        G +I  GE  R+  +  V G  +P
Sbjct: 27945 GIIMTRD-------ENVPPIVEFGPEYFDGLIIKSGESLRIKAL--VQGRPVP 27988



 Score = 37.4 bits (85), Expect = 0.31
 Identities = 156/794 (19%), Positives = 277/794 (34%), Gaps = 103/794 (12%)

Query: 2330 EEAKTIVPPHVTDSKRVQKPAIAPPSKWNIS---IFKEEPRSDQKQKSLLSFDVVDKVPQ 2386
            EE   +V P +       +    PP +  ++   + K+  +   K K +   + + K P 
Sbjct: 8955 EEIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPP 9014

Query: 2387 QPKSASSNFASKNITKESEKPESIILPVEESKGSLIDFSEDRLKKEMQNPTSLKIS-EEE 2445
             P +     A + I   S+  E  I+ +   K          ++KE +     K +  +E
Sbjct: 9015 PPTTLIPAKAPEIIDVSSKAEEVKIMTITRKK---------EVQKEKEAVYEKKQAVHKE 9065

Query: 2446 TKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTEL 2505
             ++   S  E  D LE   YT   ++   E+ +        D  EI            E 
Sbjct: 9066 KRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDE-------DYEEI----------KVEA 9108

Query: 2506 KESKADAMPQHFYQNEDYNERPKIIVGSEKEKGE--EKENQVYVLSEGKKQQEHQPYSVN 2563
            K+   +   + F + ++Y ER +     E+E  E  ++   + V  E  ++   +     
Sbjct: 9109 KKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAK 9168

Query: 2564 VAESMS-------RESDISLGHSLGETQSFSLVKATSVTEKSEAMLAE------AHPEIR 2610
            V E  +       ++  I              V+ T V E S+ ++ +         E+ 
Sbjct: 9169 VPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVI 9228

Query: 2611 EAK--AVGTQPHPLEESKVL-VEKTKTFLPVALSCRDEIENHSLSQEG-NLVLEKSSRDM 2666
            E K  AV T+   + E K+     T+  + V +    E++   +++E  ++ + K     
Sbjct: 9229 EVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVP---EVQKEIVTEEKIHVAISKRVEPP 9285

Query: 2667 PDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLEESKVLVEKTKTFLPV 2726
            P   E  E+    E++    V I K+      +   V  +P P E+  V V K +   P 
Sbjct: 9286 PKVPELPEKPAPEEVAP---VPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPP 9342

Query: 2727 VLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVDITKESMKEGF 2786
             +    E+    + +E   V     ++ P     + Q       K   V   +ES     
Sbjct: 9343 KVP---EVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAV 9399

Query: 2787 PS----KESERTLARPFDETKSSETPPYLLSPVKPQTLASGASPEINAVKKKEMPRSELT 2842
            P     K  E     P  E +    P     P KP      A P +   KK   PR+E++
Sbjct: 9400 PEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVP-VPVAKKAPPPRAEVS 9458

Query: 2843 PERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSAS 2902
             +         +++  S    Q V V++H + A E+    E       +  +        
Sbjct: 9459 KKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEE 9518

Query: 2903 NADKMVSNKEMPKEPEDTYAKGEDFTVTSK-----PAGLSEDQKTAFSIISEGCEILNIH 2957
             A+  V+  E+ +EPE+ Y   E   + SK     PA ++E Q+           +L   
Sbjct: 9519 EAE--VTEYEVMEEPEE-YVVEEKLHIISKRVEAEPAEVTERQEKKI--------VLKPK 9567

Query: 2958 APAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVACHKTLKSRLEDEKVTPLK 3017
             PA I      +  +   K+         K +P P   +     K    ++ +E   P+ 
Sbjct: 9568 IPAKIEEPPPAKVPEAPKKI------VPEKKVPAPVPKK----EKVPPPKVPEEPKKPVP 9617

Query: 3018 ENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLIDYNISPDPEKQKAPQKLN 3077
            E K        EE      T+       I  EE      T           K++AP K  
Sbjct: 9618 EKKVPPKVIKMEEPLPAKVTERHM---QITQEEKVLVAVT-----------KKEAPPKAR 9663

Query: 3078 VEEKLSKEVTEETI 3091
            V E+  + V EE +
Sbjct: 9664 VPEEPKRAVPEEKV 9677



 Score = 37.0 bits (84), Expect = 0.40
 Identities = 81/439 (18%), Positives = 173/439 (39%), Gaps = 83/439 (18%)

Query: 2528 KIIVGSEKEKGEE-----------KENQVYVLSEGKKQQEHQPY--SVNVAESMSRESDI 2574
            K++V ++K K +E           K+ Q++V  E  +++  + +   V ++ + ++E + 
Sbjct: 478  KVVVAADKAKEQELKSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAKEQET 537

Query: 2575 SLGHSLGETQ----SFSLVKATSVTEKSEAMLA-------EAHPEIREAKAVGTQPHPLE 2623
             +   + + Q      ++ + T +T  S  ++A       E  P  +E          L 
Sbjct: 538  RISEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLS 597

Query: 2624 ESKVLVEKTKTFLPVALSCRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSK 2683
              K++ E  KT +P  +    +++   L   G   +  + R+    ++EK + +E+E + 
Sbjct: 598  YEKIMKETRKTVVPKVIVATPKVKEQDLVSRGREGI-TTKREQVQITQEKMR-KEAEKTA 655

Query: 2684 GGSVDIT------KETVKQGFQEKAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENH 2737
              ++ +       +ET+ +  +  A   +   +   KV V K    +  V++  D+    
Sbjct: 656  LSTIAVATAKAKEQETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVR 715

Query: 2738 SLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVDITKESMKEGFPSKESERTLAR 2797
               + G+L               +E + +            + +++ G+  + S   +A 
Sbjct: 716  EPREPGHL---------------EESYAQ------------QTTLEYGYKERISAAKVAE 748

Query: 2798 PFDETKSSETPPYLLSPVKPQTLASGASPEINAVKKKEM-------PRSELTPERHTVHT 2850
            P    + +  P  +   VKP+ + + +   I    +K M         ++LT ER  VH 
Sbjct: 749  P--PQRPASEPHVVPKAVKPRVIQAPSETHIKTTDQKGMHISSQIKKTTDLTTER-LVHV 805

Query: 2851 IQTSKDDTS--DVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSA-SNADKM 2907
             +  +  +    V K SV  ++H  EA          S A S  A      SA S+A K+
Sbjct: 806  DKRPRTASPHFTVSKISVPKTEHGYEA----------SIAGSAIATLQKELSATSSAQKI 855

Query: 2908 VSNKEMPK-EPEDTYAKGE 2925
              + + P  +P +T  + E
Sbjct: 856  TKSVKAPTVKPSETRVRAE 874



 Score = 36.6 bits (83), Expect = 0.52
 Identities = 53/206 (25%), Positives = 90/206 (43%), Gaps = 32/206 (15%)

Query: 3704  VPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQ----EVNE--LVE 3757
             +P PP + P+E  +     I + W+  + D  +    Y +++ +        VN+  +V 
Sbjct: 29239 IPSPPGI-PEEVGTGKEHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVY 29296

Query: 3758  EYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTA---------PSTPV 3808
             + RL V     + E  +    YQ  V AVN  G S PSE + F +          PS P 
Sbjct: 29297 DTRLKVTS---LMEGCD----YQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAP- 29348

Query: 3809  IRAEDCTVCWNTATIRW-RPTTPEATET--YTLEYCRQHSPEGEGLRSFSGIKGLQLKV- 3864
              R  D T   ++ ++ W +P     T+   Y LE   + + +   + + + I+  +  V 
Sbjct: 29349 -RVVDTTK--HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVP 29405

Query: 3865  NLQPNDNYFFYVRAINAFGTSEQSEA 3890
             +L+    Y F V A+N  G SE SE+
Sbjct: 29406 DLKMGQKYSFRVAAVNVKGMSEYSES 29431



 Score = 36.2 bits (82), Expect = 0.68
 Identities = 38/145 (26%), Positives = 59/145 (40%), Gaps = 19/145 (13%)

Query: 3705  PQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVK 3764
             P PP     E    T ++I++ W    +D     + Y +E  ++     + V E    + 
Sbjct: 15705 PGPPSCP--EVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLIT 15762

Query: 3765  ESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPV---------IRAEDCT 3815
                C+  +L+  R Y+  V AVN  G S PS+       P+T +         I A+DC 
Sbjct: 15763 TCECVVPNLKELRKYRFRVKAVNEAGESEPSDTT--GEIPATDIQEEPEVFIDIGAQDCL 15820

Query: 3816  VCWN------TATIRWRPTTPEATE 3834
             VC         A I+ RPT   + E
Sbjct: 15821 VCKAGSQIRIPAVIKGRPTPKSSWE 15845



 Score = 35.4 bits (80), Expect = 1.2
 Identities = 59/247 (23%), Positives = 95/247 (38%), Gaps = 24/247 (9%)

Query: 3705  PQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVK 3764
             P+PP   P E    T +++++ WS  K+D       Y +E  + +   ++ V   +  + 
Sbjct: 30329 PEPPS-NPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIE--RKETSTDKWVRHNKTQIT 30385

Query: 3765  ESYCIFEDLEPDRCYQVWVMAVNFTG---CSLPSERAIFR---TAPSTPVIRAEDCTVCW 3818
              +      L PD  YQ  ++A N  G    S  SE  + +     PS P    E  ++  
Sbjct: 30386 TTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPG-ELEILSISK 30444

Query: 3819  NTATIRW-RPTTPEATET--YTLEYCRQHSPEGEGLRSFSGIKGLQLKV-NLQPNDNYFF 3874
             ++ T++W +P      E   Y +EY RQ         +   IK  Q  +  L     Y F
Sbjct: 30445 DSVTLQWEKPECDGGKEILGYWVEY-RQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEF 30503

Query: 3875  YVRAINAFGTSEQSEAAL-ISTRGTRFLLLRETAHPALHISSSGTVISFGERRRLTEIPS 3933
              V A N  G S     A+ I T+      L     P +           GE  +L+    
Sbjct: 30504 RVFAENETGLSRPRRTAMSIKTK------LTSGEAPGIRKEMKDVTTKLGEAAQLS--CQ 30555

Query: 3934  VLGEELP 3940
             ++G  LP
Sbjct: 30556 IVGRPLP 30562



 Score = 34.7 bits (78), Expect = 2.0
 Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 5/79 (6%)

Query: 3819  NTATIRWRPTTPEATE---TYTLEYCR-QHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFF 3874
             N+A I W+P   +       Y +E C  +   E + + S   +   ++ VNL  N  Y+F
Sbjct: 30738 NSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRI-VNLTENAGYYF 30796

Query: 3875  YVRAINAFGTSEQSEAALI 3893
              V A N FG S+  E + +
Sbjct: 30797 RVSAQNTFGISDPLEVSSV 30815



 Score = 34.3 bits (77), Expect = 2.6
 Identities = 35/120 (29%), Positives = 47/120 (39%), Gaps = 11/120 (9%)

Query: 3780  QVWVMAVNFTGCSLPSERAIFR-----TAPSTPVIRAEDCTVCWNTATIRWRPTTPEATE 3834
             Q  V A N  G   PSE          T+P +P +             I W+P       
Sbjct: 14255 QFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGS 14314

Query: 3835  T---YTLEYCRQHSPEGEGLRSFSGIKGLQLKVN--LQPNDNYFFYVRAINAFGTSEQSE 3889
                 Y +E C   + +   + S   IK L+ KV   + P+  Y   VRA+NA G SE SE
Sbjct: 14315 PIIGYHVEMCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSE 14373



 Score = 33.5 bits (75), Expect = 4.4
 Identities = 50/170 (29%), Positives = 71/170 (41%), Gaps = 27/170 (15%)

Query: 3746  PQDD--QEVNELVEEYRLTVKESYCIFEDLEPDRCYQVW-----------VMAVNFTGCS 3792
             PQ+D   E+   + E R T + ++ I E   P   Y V            V AVN  G  
Sbjct: 29164 PQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPG 29223

Query: 3793  LP--SERAIFR---TAPSTPVIRAEDCTVCWNTATIRWRPTTPEAT-----ETYTLEYCR 3842
             +P  SE  + R   T PS P I  E+         I+W  T PE+        Y ++   
Sbjct: 29224 VPVESEPIVARNSFTIPSPPGI-PEEVGTGKEHIIIQW--TKPESDGGNEISNYLVDKRE 29280

Query: 3843  QHSPEGEGLRSFSGIKGLQLKV-NLQPNDNYFFYVRAINAFGTSEQSEAA 3891
             + S     +     +   +LKV +L    +Y F V A+NA G SE SEA+
Sbjct: 29281 KKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEAS 29330



 Score = 33.5 bits (75), Expect = 4.4
 Identities = 52/231 (22%), Positives = 82/231 (35%), Gaps = 19/231 (8%)

Query: 1941  EVRKQVLPH--SAEESHLSSQEAVSALDTSSGNTETLSS-----KSYSSEEVKLAEEPKS 1993
             EV + V P     E   +SS +  S ++ SS   E  S      +S SS E   + E KS
Sbjct: 32479 EVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKS 32538

Query: 1994  LVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVS 2053
               L        +  ++I + + +  L   ++ T     S   S +    P        V+
Sbjct: 32539 AALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-----VT 32593

Query: 2054  GLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLE-------ESK 2106
              L   QV S +    V T  + +     ++    E + S      E   E       +  
Sbjct: 32594 WLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKA 32653

Query: 2107  MVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPT 2157
              V  K +      K P P VK P   K    + + EP  P++   T+  PT
Sbjct: 32654 RVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPT 32704



 Score = 32.7 bits (73), Expect = 7.5
 Identities = 84/417 (20%), Positives = 168/417 (40%), Gaps = 91/417 (21%)

Query: 3319 MQKKAPITEDVRVATQKISYAVP--FEDTHHVLERADEAGSHGNEVGNASPEVNLNVPVQ 3376
            + KK  + E   VA +K+S+AVP   E T H +  A+E  S+  E    S  V       
Sbjct: 9457 VSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVS-AEEEWSYSEEEEGVSISV------- 9508

Query: 3377 VSFPEEEFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDI 3436
              + EEE        +E  + E +++  PE             EY   E LH       I
Sbjct: 9509 --YREEE----REEEEEAEVTEYEVMEEPE-------------EYVVEEKLH-------I 9542

Query: 3437 LSEELSSESTPEDVLSQGKESFEHISENEFASEAEQSTPAE----QKELGSERK------ 3486
            +S+ + +E  P +V  + ++    + + +  ++ E+  PA+     K++  E+K      
Sbjct: 9543 ISKRVEAE--PAEVTERQEKKI--VLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVP 9598

Query: 3487 EEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVK 3546
            +++++    V E+ +K + + ++       + P+ A  KV  T +  +++  +  + AV 
Sbjct: 9599 KKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPA--KV--TERHMQITQEEKVLVAVT 9654

Query: 3547 VQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQN----EEMMKKVLAQ 3602
             + A     + E+  R               EE   K + + EE+      E  K+V+  
Sbjct: 9655 KKEAPPKARVPEEPKRA------------VPEEKVLKLKPKREEEPPAKVTEFRKRVV-- 9700

Query: 3603 YDEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEIN 3662
              E+  S E  K++        ++   +   T ++   ++ RE EE +E      +EE +
Sbjct: 9701 -KEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQRE-EEYEE------YEEYD 9752

Query: 3663 ERLLSAMESTASLEKMPAAFSLFEHYDDSS----ARSDQMLKQVAVPQPPRLEPQEP 3715
             +     E T   ++       +E Y++         ++ + +   P P +  P+EP
Sbjct: 9753 YKEFEEYEPTEEYDQ-------YEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEP 9802


>gi|223890259 midline 2 isoform 2 [Homo sapiens]
          Length = 705

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 58/239 (24%), Positives = 119/239 (49%), Gaps = 4/239 (1%)

Query: 3505 KKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLRIE 3564
            +  +++ YC +    I A  K+ G H+DH+V++L+     +K  L   L NL +++  +E
Sbjct: 199  ENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELE 258

Query: 3565 AFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLHEQ 3624
              ++++      +E N + +E +L E+ +E+++ +  +    A   +E K  K+  L +Q
Sbjct: 259  NQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQ 318

Query: 3625 MVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAFSL 3684
            + +  Q ++ +   +       +E D+A FL S + I ER+  A  S+  L         
Sbjct: 319  VANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDA 378

Query: 3685 FEHYDDSSARSDQMLK---QVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQV 3740
            FE++    +R  ++L+    +  P PP +  +E  +A+  TI V+W  + E  I S+++
Sbjct: 379  FENFALDFSREKKLLEGLDYLTAPNPPSIR-EELCTASHDTITVHWISDDEFSISSYEL 436



 Score = 80.1 bits (196), Expect = 4e-14
 Identities = 81/338 (23%), Positives = 130/338 (38%), Gaps = 28/338 (8%)

Query: 3750 QEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVI 3809
            Q    + E   +    S  +  D+  +  ++ +  A++F+      E   + TAP+ P I
Sbjct: 350  QSAKNIAERVAMATASSQVLIPDINFNDAFENF--ALDFSREKKLLEGLDYLTAPNPPSI 407

Query: 3810 RAEDCTVCWNTATIRWRPTTPEATETYTLEYCRQHSPEGEGLRSFSGIKGLQLKVN---- 3865
            R E CT   +T T+ W      +  +Y L+Y    + +   +  ++ +    +  N    
Sbjct: 408  REELCTASHDTITVHWISDDEFSISSYELQY-TIFTGQANFISLYNSVDSWMIVPNIKQN 466

Query: 3866 ------LQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPALHISSSGTV 3919
                  LQ    Y F V+AIN  G S  SE   + T    F L  +  H  L IS+ G  
Sbjct: 467  HYTVHGLQSGTRYIFIVKAINQAG-SRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQ 525

Query: 3920 IS----------FGERRRLTEIPSVLGEELPSCGQHYWETTVTDCPAYRLGICSSSAVQA 3969
            +             ER   T      G      G HYWE  +     Y +GI   SA + 
Sbjct: 526  MEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAIGIAYKSAPKN 585

Query: 3970 GALGQGETSW-YMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRLIFINAESE 4028
              +G+  +SW +  C+    +   ++     V V     R+G+LLDY+N  L F +  + 
Sbjct: 586  EWIGKNASSWVFSRCN--SNFVVRHNNKEMLVDVPPHLKRLGVLLDYDNNMLSFYDPANS 643

Query: 4029 QLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSV 4066
              L      F   V P F +       L  G+  PD +
Sbjct: 644  LHLHTFDVTFILPVCPTFTIWNKSLMILS-GLPAPDFI 680


>gi|223890257 midline 2 isoform 1 [Homo sapiens]
          Length = 735

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 58/239 (24%), Positives = 119/239 (49%), Gaps = 4/239 (1%)

Query: 3505 KKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLRIE 3564
            +  +++ YC +    I A  K+ G H+DH+V++L+     +K  L   L NL +++  +E
Sbjct: 199  ENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELE 258

Query: 3565 AFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLHEQ 3624
              ++++      +E N + +E +L E+ +E+++ +  +    A   +E K  K+  L +Q
Sbjct: 259  NQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQ 318

Query: 3625 MVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAFSL 3684
            + +  Q ++ +   +       +E D+A FL S + I ER+  A  S+  L         
Sbjct: 319  VANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDA 378

Query: 3685 FEHYDDSSARSDQMLK---QVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQV 3740
            FE++    +R  ++L+    +  P PP +  +E  +A+  TI V+W  + E  I S+++
Sbjct: 379  FENFALDFSREKKLLEGLDYLTAPNPPSIR-EELCTASHDTITVHWISDDEFSISSYEL 436



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 86/367 (23%), Positives = 132/367 (35%), Gaps = 56/367 (15%)

Query: 3750 QEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVI 3809
            Q    + E   +    S  +  D+  +  ++ +  A++F+      E   + TAP+ P I
Sbjct: 350  QSAKNIAERVAMATASSQVLIPDINFNDAFENF--ALDFSREKKLLEGLDYLTAPNPPSI 407

Query: 3810 RAEDCTVCWNTATIRWRPTTPEATETYTLEY----------------------------- 3840
            R E CT   +T T+ W      +  +Y L+Y                             
Sbjct: 408  REELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEA 467

Query: 3841 --CRQHSPEGEGLRS-------FSGIKGLQLKVN-LQPNDNYFFYVRAINAFGTSEQSEA 3890
              C + +    GL +          IK     V+ LQ    Y F V+AIN  G S  SE 
Sbjct: 468  VSCSRLAGAPRGLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAG-SRNSEP 526

Query: 3891 ALISTRGTRFLLLRETAHPALHISSSGTVISFGE----------RRRLTEIPSVLGEELP 3940
              + T    F L  +  H  L IS+ G  +   E          R   T      G    
Sbjct: 527  TRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFI 586

Query: 3941 SCGQHYWETTVTDCPAYRLGICSSSAVQAGALGQGETSW-YMHCSEPQRYTFFYSGIVSD 3999
              G HYWE  +     Y +GI   SA +   +G+  +SW +  C+    +   ++     
Sbjct: 587  DSGCHYWEVVMGSSTWYAIGIAYKSAPKNEWIGKNASSWVFSRCN--SNFVVRHNNKEML 644

Query: 4000 VHVTERPARVGILLDYNNQRLIFINAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLG 4059
            V V     R+G+LLDY+N  L F +  +   L      F   V P F +       L  G
Sbjct: 645  VDVPPHLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILS-G 703

Query: 4060 IEPPDSV 4066
            +  PD +
Sbjct: 704  LPAPDFI 710


>gi|34878844 tripartite motif-containing 55 isoform 3 [Homo sapiens]
          Length = 452

 Score = 80.1 bits (196), Expect = 4e-14
 Identities = 46/217 (21%), Positives = 111/217 (51%), Gaps = 1/217 (0%)

Query: 3486 KEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAV 3545
            K+E     +   +   +E ++ +I+ YC  C+ P  +  KVFG HKD +V+ L       
Sbjct: 109  KQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQ 168

Query: 3546 KVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDE 3605
            K +L++ +  L   + R++  +S++E    TIEE C K ++ L E+ + +   +  + +E
Sbjct: 169  KSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNE 228

Query: 3606 KAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERL 3665
              Q     +++K+E +   +  +   ++     +E+ ++  +E + AVFL + + + +++
Sbjct: 229  MTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKI 288

Query: 3666 LSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQV 3702
              A ++   +EK+   +    H+  +  R +++++++
Sbjct: 289  SEASKA-FQMEKIEHGYENMNHFTVNLNREEKIIREI 324


>gi|34878836 tripartite motif-containing 55 isoform 1 [Homo sapiens]
          Length = 548

 Score = 80.1 bits (196), Expect = 4e-14
 Identities = 46/217 (21%), Positives = 111/217 (51%), Gaps = 1/217 (0%)

Query: 3486 KEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAV 3545
            K+E     +   +   +E ++ +I+ YC  C+ P  +  KVFG HKD +V+ L       
Sbjct: 109  KQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQ 168

Query: 3546 KVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDE 3605
            K +L++ +  L   + R++  +S++E    TIEE C K ++ L E+ + +   +  + +E
Sbjct: 169  KSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNE 228

Query: 3606 KAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERL 3665
              Q     +++K+E +   +  +   ++     +E+ ++  +E + AVFL + + + +++
Sbjct: 229  MTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKI 288

Query: 3666 LSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQV 3702
              A ++   +EK+   +    H+  +  R +++++++
Sbjct: 289  SEASKA-FQMEKIEHGYENMNHFTVNLNREEKIIREI 324


>gi|34878821 tripartite motif-containing 55 isoform 2 [Homo sapiens]
          Length = 540

 Score = 80.1 bits (196), Expect = 4e-14
 Identities = 46/217 (21%), Positives = 111/217 (51%), Gaps = 1/217 (0%)

Query: 3486 KEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAV 3545
            K+E     +   +   +E ++ +I+ YC  C+ P  +  KVFG HKD +V+ L       
Sbjct: 109  KQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQ 168

Query: 3546 KVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDE 3605
            K +L++ +  L   + R++  +S++E    TIEE C K ++ L E+ + +   +  + +E
Sbjct: 169  KSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNE 228

Query: 3606 KAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERL 3665
              Q     +++K+E +   +  +   ++     +E+ ++  +E + AVFL + + + +++
Sbjct: 229  MTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKI 288

Query: 3666 LSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQV 3702
              A ++   +EK+   +    H+  +  R +++++++
Sbjct: 289  SEASKA-FQMEKIEHGYENMNHFTVNLNREEKIIREI 324


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 79.3 bits (194), Expect = 7e-14
 Identities = 444/2415 (18%), Positives = 894/2415 (37%), Gaps = 409/2415 (16%)

Query: 897  STSASEFSVPPYATPEAQEEEIVHRSLNLKGASSP---------MNLSEEDQEDIGP--- 944
            S    E SV      EAQEE I    L L+G  +            + + + E I P   
Sbjct: 553  SQKHKELSVLLLEMKEAQEE-IAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKM 611

Query: 945  --FSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDS 1002
              F  D+    +F   P         E E  S    +  SE   L+D   E         
Sbjct: 612  KVFLEDTG--QDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGD 669

Query: 1003 ASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAA-----TPVSEQ 1057
             S  ++P   I +  ++ELE            +    E  E+++   A        + E+
Sbjct: 670  KSLSAVPD--IGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE 727

Query: 1058 FSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQA 1117
            F  +    +  F  +S   D  L    + S   E++ ++     +++E    A++Q+   
Sbjct: 728  FKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAE----AERQRRLD 783

Query: 1118 YLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSV 1177
            Y   ES+    + LT ++                ++ A+S  VK E        VL + +
Sbjct: 784  Y---ESQTAHDNLLTEQIHS-------------LSIEAKSKDVKIE--------VLQNEL 819

Query: 1178 PAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESE 1237
              ++ +    + L +++   Q+      KE  V +  E   H+S   K+E     + + E
Sbjct: 820  DDVQLQFSEQSTL-IRSLQSQLQ----NKESEVLEGAERVRHISS--KVEELSQALSQKE 872

Query: 1238 MKYSVLPDMVDEPKKGV---------KPKLVLNVTSELEQRKLSKNEPEVIK--PYSPLK 1286
            ++ + +  ++ E K+ V         K + V  ++  + ++ +  NE +         LK
Sbjct: 873  LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932

Query: 1287 ETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPA--LAFSALSEE-- 1342
            E       A  A K +++ D+++          SSG+++  +   PA  ++   L  E  
Sbjct: 933  EQLNLLSRAEEAKKEQVEEDNEV----------SSGLKQNYDEMSPAGQISKEELQHEFD 982

Query: 1343 -IKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLP 1401
             +KKE E       A++      L R  + E    +          L++  +GE+     
Sbjct: 983  LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKE 1042

Query: 1402 PLVTSADEHSVLAEEDKVAIKGA-SPIETSSKHLAWSEAEK---EIKFDSL-----PSVS 1452
                S    +   +E ++ +K   S  E   +H+     EK   E +F +L      ++ 
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ 1102

Query: 1453 SIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVC--------- 1503
                   L + E  E +A +  + TS++  SD    A V  K+ ++ S  C         
Sbjct: 1103 DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV--KETVVISPPCTGSSEHWKP 1160

Query: 1504 -----------DSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETEL-------- 1544
                       + E+L    +++L S   +L+   E    L  E+K+++ +         
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFD 1220

Query: 1545 ---PSSQNVSPASKHI-----------IPKGKDEETASSSPELENLASGLAPTLLLLSDD 1590
                 ++N+    + +           +P    +E+ SS+P LE       P        
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEE------PLFKATEQH 1274

Query: 1591 KNKPAVEVSSTAQGDFPSEKQDVALAE-----LSLEPEKKDKPHQPLELPNAGSEFSSDL 1645
              +P +E  S    D+PS  +D +  +       ++ + K+   + +EL    S  +S+L
Sbjct: 1275 HTQPVLE--SNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL 1332

Query: 1646 GRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRELCASSTMPAISELSSLLR 1705
             ++S  +   Q +          + K   E+ S +      E+ A S      +L S   
Sbjct: 1333 TKKSEEVFQLQEQ----------INKQGLEIESLKTVSHEAEVHAESLQ---QKLESSQL 1379

Query: 1706 EESQNEEIKPFSPKIISLES----KEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADF 1761
            + +  E ++   PK+  L+     KE   S   G   E+      +L  +  E+    D 
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK----EAALTKIQTEIIEQEDL 1435

Query: 1762 KKGGNQEIGPLPPTGNLKAQVMGDILDKLS---EETGHPN-SSQVLQSITEPSKIAPSDL 1817
             K  + ++       + + + +   L ++    EE G  + + Q +Q   + + I+  + 
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495

Query: 1818 LVEQKKTEKALHSDQ------TVKLPDVST--SSEDKQDLGIKQFSLMRENLPLEQSKSF 1869
            L E K  ++ L   +      T  L DV +  S+++K+    K   L R  L  E+    
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE----KDTVLGRLALLQEERDKL 1551

Query: 1870 MTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQL 1929
            +T    ++  + +E   +S   E+  L   E +    E+ +     L SS   E    Q 
Sbjct: 1552 IT----EMDRSLLENQSLSSSCESLKLAL-EGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606

Query: 1930 KAAVSSKDHTCEVRK--------QVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYS 1981
            K     K++   ++         + + H  E      QE    L ++  N +    +   
Sbjct: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666

Query: 1982 SEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESE-----SLLLEKANTELSW-PSKED 2035
            +E+     + K    A + ++ I E +E +  + +E         E   T LS   S ++
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726

Query: 2036 SQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEK--EAHRST 2093
              E++K+  E   +K  S +S    + +++S  V+      EG      N +  E H + 
Sbjct: 1727 ELERVKMEYETLSKKFQSLMS----EKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ 1782

Query: 2094 PPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQ 2153
                EE    +S   +++  D      +P+    +P+ +    ++        E     Q
Sbjct: 1783 TNVTEEGT--QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840

Query: 2154 N-PPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAE-QEDLETQPSPSVE 2211
                 + ++A  +  ++K K+   + ++  ++L    ST D ++   QE++         
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV--------- 1891

Query: 2212 KAVTVIDPEGTIPTNFNVAEKPADHSLSEV-KLK-TADEPRGTLVKSGDGQNVKEKSMIL 2269
                         T  N+  +     LS V KLK TA+E +  L +    Q  +    I 
Sbjct: 1892 -------------TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIG 1938

Query: 2270 SNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEKLVM 2329
            +  +D+   +  +E+            +SE  N+   V+  + E           ++LV 
Sbjct: 1939 NYCQDVTDAQIKNELL-----------ESEMKNLKKCVSELEEEK----------QQLVK 1977

Query: 2330 EEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVV---DKVPQ 2386
            E+ K          +++Q     P +K +    +E  +  Q++   L  D +   +K+  
Sbjct: 1978 EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISA 2037

Query: 2387 QPKSASS-NFASKNITKESE-KPESIILPVEESKGS---------LIDFSEDRLKKEMQN 2435
              ++  +  F      K+ E   E++   VE  K +         L+D ++    + + +
Sbjct: 2038 LERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLAD 2097

Query: 2436 PTSLKISEEETKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLE------LRDSN 2489
               LK   +  K    S  ++KD    R    AE+K L EK+N    L+      +    
Sbjct: 2098 NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE 2157

Query: 2490 EIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNERPKIIVGSEKEKGEEKENQVYVLS 2549
             IG+ Q+TL  +  E+++ +           E+ +     +    K     ++++  V+ 
Sbjct: 2158 TIGEIQVTLNKKDKEVQQLQ-----------ENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206

Query: 2550 EGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVKATSVTEKSEAMLA--EAHP 2607
            E KK +     ++      S+E +I L           L + +   E+ +  ++  E   
Sbjct: 2207 EAKKWERKFSDAI-----QSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261

Query: 2608 EIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQEGNLVLEKSSRDMP 2667
            +I E+KA        +    L  + K  L             S  +E   +   S  ++ 
Sbjct: 2262 QIWESKAQTEVQLQQKVCDTLQGENKELL-------------SQLEETRHLYHSSQNELA 2308

Query: 2668 DHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLEESKVLVEKTKTFLPVV 2727
                E +  ++       S++  KE  ++G  E  +  Q   ++ SK   E+ +T L   
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKE--QKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366

Query: 2728 LSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVDITKESMKEGFP 2787
                  +      +E  ++   S +      EE  Q   +EL +    +I +    E   
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGK------EEAIQVAIAELRQQHDKEIKE---LENLL 2417

Query: 2788 SKESERTLARPFDETKSSETPPYLLSPVKPQTLASGASPEINAVKKKEM-PRSELTPERH 2846
            S+E E  +    +  K+ +    L+  +K              +KK+ +  +++L     
Sbjct: 2418 SQEEEENIVLEEENKKAVDKTNQLMETLK-------------TIKKENIQQKAQLDSFVK 2464

Query: 2847 TVHTIQTSKD----DTSDVPKQ--SVLVSKHHL---EAAEDTRVKEPLSSAKSNYAQFIS 2897
            ++ ++Q  +D    D   + ++  S+++ K  L    AAE+ ++KE +   +S+     S
Sbjct: 2465 SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS 2524

Query: 2898 NTSASNADKMVSNKEM---------------------PKEPEDTYAKGEDFTVTSKPAGL 2936
              +  +A+ +   +++                      KE E+ YAK E+    S+ A  
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA-- 2582

Query: 2937 SEDQKTAFSIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKT---IPLPD 2993
            +ED + +F+ +                   QEE + +  ++E L+   S  T     L +
Sbjct: 2583 NEDLRRSFNAL-------------------QEEKQDLSKEIESLKVSISQLTRQVTALQE 2623

Query: 2994 DSETVACHKTLKSRLED-EKVTPLKENKQKETHKTKEE---ISTDSETDLSFIQPTIPSE 3049
            +      H  LK + E+  +++ L  + QK   + +EE   +  ++   +  I+  +  E
Sbjct: 2624 EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKE 2683

Query: 3050 EDYFEKYTLIDYNISPDPEKQKA---------PQKLNVEEKLSKEVTEETISF--PVSSV 3098
              +      I  N +   E++ A          QKL +  K +K +T +  SF   +SS+
Sbjct: 2684 LKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL 2743

Query: 3099 ESALEHEYDLVKLDE 3113
            +++ +H  +  +LDE
Sbjct: 2744 QNSRDHANE--ELDE 2756



 Score = 76.3 bits (186), Expect = 6e-13
 Identities = 522/2842 (18%), Positives = 1039/2842 (36%), Gaps = 441/2842 (15%)

Query: 1013 ISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLM 1072
            I   +K   E  S   A+         + +E+ + S       E     + ++   F   
Sbjct: 381  ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440

Query: 1073 SPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLT 1132
             PL+       T         P++    T       +A  QK    LE E   L+ S + 
Sbjct: 441  LPLQQHETASQTSF-------PDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493

Query: 1133 SEVEKGEREASSSVAAIPAALP---------AQSSIVKEETKPASP-----HSVLPDSVP 1178
             E  K E E  SS   +  A           ++ SIV    K +S        VL ++  
Sbjct: 494  LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553

Query: 1179 AIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEM 1238
               KE      L +K A E++A  K+   ++     E   H   DQK   Q      + +
Sbjct: 554  QKHKELS-VLLLEMKEAQEEIAFLKL---QLQGKRAEEADHEVLDQKEMKQMEGEGIAPI 609

Query: 1239 KYSVLPDMVDE-----PKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSGP 1293
            K  V  +   +     P +      V    +  E +  +  E  +      LK T   G 
Sbjct: 610  KMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGD 669

Query: 1294 EALSAV-------KMEMKH-DSKITTTPIVLHSASSGVEKQVEHGPPALA-FSALSEEIK 1344
            ++LSAV       + E++   S+I    +  H A    EK ++     ++  + L EE K
Sbjct: 670  KSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFK 729

Query: 1345 KEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPLV 1404
            K  + +SS  TA   + D  L++ VKE      S++T +      +V + E+        
Sbjct: 730  KNADNNSSAFTALSEERDQLLSQ-VKE-----LSMVTELR----AQVKQLEMNLAEAERQ 779

Query: 1405 TSADEHSVLAEEDKVAIKGAS-PIETSSKHLAWSEAEKEIKFDSLP-SVSSIAEHSVLSE 1462
               D  S  A ++ +  +  S  IE  SK +     + E+    L  S  S    S+ S+
Sbjct: 780  RRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ 839

Query: 1463 VEAKE--VKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSSQKKSLMSTS 1520
            ++ KE  V  G   ++  SS+  + S+    ++ +      +   ++L+  +K+ + +  
Sbjct: 840  LQNKESEVLEGAERVRHISSKVEELSQALSQKELE------ITKMDQLLLEKKRDVETLQ 893

Query: 1521 EVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSSPELENLASGL 1580
            + +E + +    +   + +K  +L                  +EE  S   E++ L   L
Sbjct: 894  QTIEEKDQQVTEISFSMTEKMVQL------------------NEEKFSLGVEIKTLKEQL 935

Query: 1581 APTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKDKPHQPLELPNAGSE 1640
               LL  +++  K  VE  +           +++ A    +  K++  H+   L     +
Sbjct: 936  --NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG---QISKEELQHEFDLLKKENEQ 990

Query: 1641 FSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRELCASSTMPAISEL 1700
                L  Q+  I  K+    ++  E+ +     A L+     E  +E+  S T       
Sbjct: 991  RKRKL--QAALINRKELLQRVSRLEEEL-----ANLKD----ESKKEIPLSETERG---- 1035

Query: 1701 SSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPAD 1760
                 E  +++E K +S K ++ + +E    + +  + +E +          + +    +
Sbjct: 1036 -----EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVE---------LQHIRKDLE 1081

Query: 1761 FKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNSSQVLQSITEPSKIAPSDLLVE 1820
             K    ++   L    N   Q   + +D L  E    N + + + IT  +  +  D +  
Sbjct: 1082 EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISE-NQAIIQKLITSNTDASDGDSVAL 1140

Query: 1821 QKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRENLPLEQSKSFMTT------KP 1874
             K+T         +  P   +S   K +L  K  +L +E   L++      T      K 
Sbjct: 1141 VKETV-------VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193

Query: 1875 ADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVS 1934
            A  KE  + E     KD+   L +  +  S+  + I           ++LR  Q+     
Sbjct: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG----------DQLRQLQI----- 1238

Query: 1935 SKDHTCEVRKQV---LPHSAEESHLSSQEAVSA---LDTSSGNTETLSSKSYSSEEVKLA 1988
                  +VR+ +   LP + ++   SS   +       T   +T+ +   +   +    +
Sbjct: 1239 ------QVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHS 1292

Query: 1989 EEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFF 2048
            E+  +L    +V +  A+ KEI +      L +    +EL+  S+E  Q + ++  +   
Sbjct: 1293 EDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQ--- 1349

Query: 2049 QKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKP-LEESKM 2107
                 GL +E +K+ +  + V      AE ++  L + +          E +P L+E + 
Sbjct: 1350 -----GLEIESLKTVSHEAEVH-----AESLQQKLESSQLQIAGLEHLRELQPKLDELQK 1399

Query: 2108 VQSKVIDDADE-----GKKPSPEVKIPT----QRKPISSIHAR-EPQSPESPEVTQNPPT 2157
            + SK  +D         +K +   KI T    Q   I ++H + E Q+ E  E  +    
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQV 1459

Query: 2158 QPKVAKPDLPEEKG--------------------KKGISSFKSWMSSLFFGSSTPDNKVA 2197
            +    K   PEE G                    K+ +   KS    L     T +    
Sbjct: 1460 ELCEMKQK-PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTK 1518

Query: 2198 EQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSG 2257
               D+E+Q S   ++  TV+     +    +      D SL E +  ++      L   G
Sbjct: 1519 SLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEG 1578

Query: 2258 DGQNVKEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEI 2317
                 ++K  ++  +E L+  K I+E +      KE+  + E +     + S +  + E 
Sbjct: 1579 ---LTEDKEKLVKEIESLKSSK-IAESTEWQEKHKELQKEYEIL-----LQSYENVSNEA 1629

Query: 2318 QSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEPR--SDQKQKSL 2375
            +    + E +  E+ +       T++ + +       ++  +   KE+ R  +  KQ+ +
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI 1689

Query: 2376 LSFDV--------VDKVPQQPKSASSNFASKNITKESEKPESIILPVE--ESKGSLIDFS 2425
            L  +         V       K       S N + + E  E + +  E    K   +   
Sbjct: 1690 LELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL-ERVKMEYETLSKKFQSLMSE 1748

Query: 2426 EDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLEL 2485
            +D L +E+Q+    +I    +K  ++  TEK DN  N          + E+     P E 
Sbjct: 1749 KDSLSEEVQD-LKHQIEGNVSKQANLEATEKHDNQTN----------VTEEGTQSIPGET 1797

Query: 2486 RDSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYN-------ERPKIIVGSEKEKG 2538
             + + +  +     S S    +S   A+ + F  +++ N       +  + I G E+EK 
Sbjct: 1798 EEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ 1857

Query: 2539 EEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVKATSVTEKS 2598
            + KE    +  E +K       S    E    + +++  + L +     L + T + E +
Sbjct: 1858 KNKEFSQTL--ENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915

Query: 2599 EA-----------MLAEAHPEI------------------REAKAVGTQPHPLEESKVLV 2629
            E             LAE +  I                   E K +      LEE K  +
Sbjct: 1916 EEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQL 1975

Query: 2630 EKTKT---------FLPVALSCRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRES- 2679
             K KT         +L      + E  N S ++E   +L++  +++    ++  +++E  
Sbjct: 1976 VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKI 2035

Query: 2680 -------------ELSKGGSVDITKETVKQGFQEKAVGTQPRPLEESKVLVEKTKTFLPV 2726
                         +      ++ITKE + Q  + +        L   KVL++ T++    
Sbjct: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE--LASFKVLLDDTQSEAAR 2093

Query: 2727 VLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVD-----ITKES 2781
            VL+ + +++    S + ++  +   +D  D     EQ +E  L +  ++      + +E 
Sbjct: 2094 VLADNLKLKKELQSNKESVKSQMKQKD-EDLERRLEQAEEKHLKEKKNMQEKLDALRREK 2152

Query: 2782 MKEGFPSKESERTLARPFDETKSSE-----TPPYLLSPVKPQT-LASGASPEINAVKKKE 2835
            +       E + TL +   E +  +     T   L +  K  + L       I+  KK E
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212

Query: 2836 MPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAE--------DTRVKEPLSS 2887
               S+    +     +   K+D   V K  +     H+E  +        D ++ E  + 
Sbjct: 2213 RKFSDAIQSKEEEIRL---KEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQ 2269

Query: 2888 AKSNYAQFISNTSASNADKMVSNKEMPKEPEDT----YAKGEDFTVTSKPAGLSEDQKTA 2943
             +    Q + +T          NKE+  + E+T    ++   +           +DQ T 
Sbjct: 2270 TEVQLQQKVCDTLQGE------NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTD 2323

Query: 2944 FSIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVACHKT 3003
             S   E C+    +    I    Q+E++    K  Y + +   +       S  +     
Sbjct: 2324 LSNSLEKCKEQKGNLEGIIR---QQEADIQNSKFSYEQLETDLQA------SRELTSRLH 2374

Query: 3004 LKSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLIDYNI 3063
             +  ++++K+  L   K++       E+    + ++  ++  +  EE+          NI
Sbjct: 2375 EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE---------NI 2425

Query: 3064 SPDPEKQKAPQKLNVEEKLSKEVTEETISFPV---SSVESALEHEYDLVKLDESFYGPEK 3120
              + E +KA  K N   +  K + +E I       S V+S    + D  ++   +   E+
Sbjct: 2426 VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485

Query: 3121 GHN--ILSHPETQSQNSADRNVSKDTKR-------DVDSKSPGMP--LFEAEEGVLSRTQ 3169
             H   IL   +   + +A+ N  K+  R       D++S++  +   L +  E +     
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545

Query: 3170 IFPTTIKVIDPEFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSD 3229
            I  +  K +    L++   L   Y  L E+    ++  E+     +++  E    S+  +
Sbjct: 2546 IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2605

Query: 3230 T----------------DDGT-GIYFEKYILKDDILHDTSLTQKDQGQGLEEKRVGKDDS 3272
            +                ++GT G+Y  +  +K++ +H  S           +KR+ + + 
Sbjct: 2606 SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS-----QKRIAELEE 2660

Query: 3273 YQPIAAEGEIWGKFGTICREKSLEEQKGVYGE-GESVDHVETVGNVAMQKKAPITEDVRV 3331
             + +  + E   K G I  +K  +E K ++ + G   +  ET    A ++ A +  D+  
Sbjct: 2661 -ELVCVQKEAAKKVGEI-EDKLKKELKHLHHDAGIMRNETET----AEERVAELARDLVE 2714

Query: 3332 ATQKISYAVPFEDTHHVLERADEAGSHGNEVGNASPEVNLNVPVQVSFPEEEFASGATHV 3391
              QK+      ++   +  +    G   + + N+    N  +       +      A   
Sbjct: 2715 MEQKLLMVT--KENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772

Query: 3392 QETSLEEPKILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSEELSSESTPEDVL 3451
            ++  L   +  +  E +     NS  ++     E L+ +++ +D     LSS+   ED  
Sbjct: 2773 EQGLLNRERDALLSETAFSM--NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL--EDSY 2828

Query: 3452 SQGKESFEHISENEFASEAEQSTPAEQKELGSERKEEDQLSSEVVTEKAQKELKKSQIDT 3511
            +Q  +SF                    K + S + E D L +E+   +  +E K+     
Sbjct: 2829 NQ-VQSFS-------------------KAMASLQNERDHLWNELEKFRKSEEGKQR---- 2864

Query: 3512 YCYTCKCPISATDKVFGTHKDHEVSTLDTAISAV---KVQLAEFLENLQEKSLRIEAFVS 3568
                     SA      +    EV +L  A+S++   + +L + L+NLQ++ L+I   ++
Sbjct: 2865 ---------SAAQP---STSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT 2912

Query: 3569 EIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQ-----SFEEVKKKKMEFLHE 3623
            E+      ++E   K  K  +   EE+ ++ L+   E  Q     S  E+ +++M+   E
Sbjct: 2913 ELHPLKAQLQEYQDKT-KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMK---E 2968

Query: 3624 QMVHFLQSMDTAKDTLETIVRE 3645
            Q +  +   D     L+ ++RE
Sbjct: 2969 QYLMAISDKDQQLSHLQNLIRE 2990



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 503/2715 (18%), Positives = 1019/2715 (37%), Gaps = 398/2715 (14%)

Query: 1101 TSVSEYLILAQKQK-TQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSI 1159
            TS+++Y+   + Q  T    EP+SE+ +  H     +K   E    +  I   L  +  +
Sbjct: 105  TSLNKYIEEMKAQGGTVLPTEPQSEEQLSKH-----DKSSTEEEMEIEKIKHKLQEKEEL 159

Query: 1160 VKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAH 1219
            +          S L   +   + EQ P  + T       M      KEE +   Q   A 
Sbjct: 160  I----------STLQAQLTQAQAEQ-PAQSSTEMEEFVMMKQQLQEKEEFISTLQ---AQ 205

Query: 1220 VSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQ------RKLSK 1273
            +SQ Q  +     V E + ++     + ++    +  +   +V +E++Q      RKL +
Sbjct: 206  LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQA--DVETEMQQKLRVLQRKLEE 263

Query: 1274 NEPEVI--KPYSPLKETSLSGPEALSAV------KMEMKHDSKITTTPIVLHSASSGVEK 1325
            +E  ++       L +  L+  E  + +      +ME +H++   T       +   +EK
Sbjct: 264  HEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 323

Query: 1326 -QVEHGPPALAFSALSEEIKKEIEP--SSSTTTASVTKLDSNLTRAVKEEIPTDSSLITP 1382
             ++E     L+F  L EE+   +E    +    A +    S L +  K E+   +S I  
Sbjct: 324  MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383

Query: 1383 VDRPVLTKVGKGELGSGLPPLVTSADEHS-VLAEEDKVAIKGASPIETSSKHLAWSEAEK 1441
                 L K G+ EL S    L    D++S +L ++++ A++ A  I+     L     E 
Sbjct: 384  -----LQKTGQ-ELQSACDAL---KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEI 434

Query: 1442 EIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFST 1501
                + LP    + +H   S+    +V        T  +  S +     +E+++  L  +
Sbjct: 435  SQFLNRLP----LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLS 490

Query: 1502 VCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKG 1561
              + E L +  +K L S   +LE ++       GE  ++ +E+      +  S      G
Sbjct: 491  SIELEELKAENEK-LSSQITLLEAQNRT-----GEADREVSEISIVDIANKRSSSAEESG 544

Query: 1562 KDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLE 1621
            +D    + S + + L+      LLL   +  +    +    QG    E     L +  ++
Sbjct: 545  QDVLENTFSQKHKELS-----VLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMK 599

Query: 1622 PEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREG 1681
             + + +   P+++      F  D G+    +  +++  P  E E +  E           
Sbjct: 600  -QMEGEGIAPIKM----KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654

Query: 1682 KEENRELCASS-----TMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGG 1736
             +   EL ++      ++ A+ ++      +   +E++    +I+ LE     A      
Sbjct: 655  NDAGVELKSTKQDGDKSLSAVPDIG-----QCHQDELERLKSQILELELNFHKAQEIYEK 709

Query: 1737 NPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGH 1796
            N +E      +L  L EE      FKK  +                       LSEE   
Sbjct: 710  NLDEKAKEISNLNQLIEE------FKKNADNN---------------SSAFTALSEER-- 746

Query: 1797 PNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSL 1856
                Q+L  + E S +  ++L  + K+ E  L   +  +  D  + +             
Sbjct: 747  ---DQLLSQVKELSMV--TELRAQVKQLEMNLAEAERQRRLDYESQTA------------ 789

Query: 1857 MRENLPLEQSKSF-MTTKPADVK----ETKMEEFFISPKDENWMLGKPENVASQHEQRIA 1911
              +NL  EQ  S  +  K  DVK    + ++++  +   +++ ++   ++     E  + 
Sbjct: 790  -HDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVL 848

Query: 1912 GSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGN 1971
               +     S+++   +L  A+S K+       Q+L        L  +  V  L      
Sbjct: 849  EGAERVRHISSKVE--ELSQALSQKELEITKMDQLL--------LEKKRDVETLQ----- 893

Query: 1972 TETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWP 2031
             +T+  K     E+  +   K + L    E   + G EI +L E  +LL  +A       
Sbjct: 894  -QTIEEKDQQVTEISFSMTEKMVQLN---EEKFSLGVEIKTLKEQLNLL-SRAEEAKKEQ 948

Query: 2032 SKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHR 2091
             +ED++    L        P   +S E+++ E      K        ++ AL N KE  +
Sbjct: 949  VEEDNEVSSGLKQNYDEMSPAGQISKEELQHE-FDLLKKENEQRKRKLQAALINRKELLQ 1007

Query: 2092 STPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISS------IHAREPQS 2145
                  EE    + +  +   + + + G+    +       K ++S      I+ ++  S
Sbjct: 1008 RVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS 1067

Query: 2146 PESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQ 2205
             +  E+           + DL E+   +    F++ +  +   + T  +K  + + L+ +
Sbjct: 1068 EKEVELQH--------IRKDLEEKLAAE--EQFQALVKQM---NQTLQDKTNQIDLLQAE 1114

Query: 2206 PSPS---VEKAVT----VIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSGD 2258
             S +   ++K +T      D +        V   P     SE      +E    L K  +
Sbjct: 1115 ISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKE 1174

Query: 2259 GQNVKEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQ 2318
                K +  + S    L++ +      RE+   K+   D   +       S + EN+  Q
Sbjct: 1175 QLQKKLQEALTSRKAILKKAQEKERHLREEL--KQQKDDYNRLQEQFDEQSKENENIGDQ 1232

Query: 2319 SYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSF 2378
               L  +  V E     +P           P +  P      +FK   +     + +L  
Sbjct: 1233 LRQL--QIQVRESIDGKLPSTDQQESCSSTPGLEEP------LFKATEQ--HHTQPVLES 1282

Query: 2379 DVVDKVPQQPKSASSNFASKNITK--------ESEKPESIILPVEESKGSLIDFSED--- 2427
            ++    P   + AS+     ++ +        E+EK E + L V  +   L   SE+   
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE-LELKVSSTTSELTKKSEEVFQ 1341

Query: 2428 ---RLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSYTLAE-----------KKVL 2473
               ++ K+     SLK    E ++ + S  +K ++ + +   L             +K++
Sbjct: 1342 LQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI 1401

Query: 2474 AEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNERPKIIVGS 2533
            ++K+  V+ L    S ++ + +  L    TE+ E +      H        E  + I   
Sbjct: 1402 SKKEEDVSYL----SGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQL 1457

Query: 2534 EKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVKATS 2593
            + E  E K+    +  E + +Q+ Q      A  +SR+  +    SL E  S +      
Sbjct: 1458 QVELCEMKQKPEEIGEESRAKQQIQRKLQ--AALISRKEALKENKSLQEELSLARGTIER 1515

Query: 2594 VTEKSEAMLAEAHPEIREAKAVGTQPHPLEES--KVLVEKTKTFLPVALSCRDEIENHSL 2651
            +T+    + ++   + +E   V  +   L+E   K++ E  ++ L          EN SL
Sbjct: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL----------ENQSL 1565

Query: 2652 S---QEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPR 2708
            S   +   L LE  + D     +E E  + S++++              +QEK    Q  
Sbjct: 1566 SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE-----------WQEKHKELQ-- 1612

Query: 2709 PLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESE 2768
              +E ++L++  +            +E  ++ QE   +  K      +  E ++Q +E+E
Sbjct: 1613 --KEYEILLQSYENVSNEAERIQHVVE--AVRQEKQELYGKLRSTEANKKETEKQLQEAE 1668

Query: 2769 LWKGGSVDITKESMKEGFPSKESE-RTLARPFDETKSSETPPYLLSPVKPQTLASGASPE 2827
                  ++  KE M++   SK+ +   L    D  ++   P    +    +TL S     
Sbjct: 1669 Q----EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS---- 1720

Query: 2828 INAVKKKEMPRSELTPERHT--VHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPL 2885
             NA  K+E+ R ++  E  +    ++ + KD  S+     V   KH +E     +     
Sbjct: 1721 -NASMKEELERVKMEYETLSKKFQSLMSEKDSLSE----EVQDLKHQIEGNVSKQANLEA 1775

Query: 2886 SSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQKTAFS 2945
            +    N        + S   +      +      T ++      ++ PA +S+D  +   
Sbjct: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA-VSKDFSSHDE 1834

Query: 2946 IISEGCEILNIHAPAFISSIDQEE------SEQMQDKLEYLEEKASFKTIPLPDDSETVA 2999
            I +   +I  +     I+ +++E+      S+ ++++   L  + S K   L    E V 
Sbjct: 1835 INNYLQQIDQLKER--IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892

Query: 3000 CHKTLKSRLEDE--KVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYT 3057
                L  ++++E  +VT LKE  ++E    +E +          I        D   K  
Sbjct: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952

Query: 3058 LIDYNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYG 3117
            L++  +      +K   +L  EE+  + V E+T       VES +  EY      E   G
Sbjct: 1953 LLESEMK---NLKKCVSEL--EEEKQQLVKEKT------KVESEIRKEYL-----EKIQG 1996

Query: 3118 PEKGHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTIKV 3177
             +K       P  +S     + + K+ +++V         ++ +   L RT      +K 
Sbjct: 1997 AQK------EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT------VKA 2044

Query: 3178 IDPEFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGTGIY 3237
            ++    E    L    ++L +     KK + E AS    ++   S  +R           
Sbjct: 2045 LEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAAR----------- 2093

Query: 3238 FEKYILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEE 3297
                +L D++     L    +    + K+  KD+  +    + E          EK L+E
Sbjct: 2094 ----VLADNLKLKKELQSNKESVKSQMKQ--KDEDLERRLEQAE----------EKHLKE 2137

Query: 3298 QKGVYGE-----GESVDHVETVGN--VAMQKKAPITEDVR-----VATQKISYAVPF--- 3342
            +K +  +      E V   ET+G   V + KK    + ++       TQ  ++       
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL 2197

Query: 3343 -EDTHHVLERADE-AGSHGNEVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPK 3400
             +D   V++ A +      + + +   E+ L      S  +++    + H     +EE K
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED-NCSVLKDQLRQMSIH-----MEELK 2251

Query: 3401 ILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKES--F 3458
            I +     ++++  S  Q E +           Q  + + L  E+  +++LSQ +E+   
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQL----------QQKVCDTLQGEN--KELLSQLEETRHL 2299

Query: 3459 EHISENEFAS-EAEQSTPAEQ-KELGS--ERKEEDQLSSEVVTEKAQKELKKS-----QI 3509
             H S+NE A  E+E  +  +Q  +L +  E+ +E + + E +  + + +++ S     Q+
Sbjct: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL 2359

Query: 3510 DTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLRIEAFVSE 3569
            +T     +   S   +     +   +S L     A++V +AE  +   ++   +E  +S+
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ 2419

Query: 3570 IESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLHEQMVHFL 3629
             E      EEN       LEE+N    KK + + ++  ++ + +KK+ ++    Q+  F+
Sbjct: 2420 EE------EENIV-----LEEEN----KKAVDKTNQLMETLKTIKKENIQ-QKAQLDSFV 2463

Query: 3630 QSMDTAKDTLETIVREAEELDE---AVFLTSFEEINERLLSAMESTASLEKMPAAFSLFE 3686
            +SM + ++  + IV + ++L+E   ++ L   + I E   +A E+    E++    S  +
Sbjct: 2464 KSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQE---AAAENNKLKEEIRGLRSHMD 2520

Query: 3687 HYDDSSARSDQMLKQ 3701
              +  +A+ D  L Q
Sbjct: 2521 DLNSENAKLDAELIQ 2535



 Score = 58.2 bits (139), Expect = 2e-07
 Identities = 375/2112 (17%), Positives = 801/2112 (37%), Gaps = 305/2112 (14%)

Query: 1762 KKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGH--PNSSQVLQSITEPSKIAPSDLLV 1819
            +K  + +I  L      K   +   ++++  + G   P   Q  + +++  K +  + + 
Sbjct: 86   RKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145

Query: 1820 EQKKTEKALHSDQTV-----KLPDVSTSSEDKQDLGIKQFSLMRENLPLEQSKSFMTTKP 1874
             +K   K    ++ +     +L         +    +++F +M++ L  ++ + F++T  
Sbjct: 146  IEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL--QEKEEFISTLQ 203

Query: 1875 ADVKETKMEEF---FISPKDENWMLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQLKA 1931
            A + +T+ E+     +  KD  +     E     HE  +   +QL + +  E    Q   
Sbjct: 204  AQLSQTQAEQAAQQVVREKDARF-----ETQVRLHEDEL---LQLVTQADVETEMQQKLR 255

Query: 1932 AVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTS---SGNTETLSSKSYSSEEVKLA 1988
             +  K    E  ++ L   A+   L  QE  +A   +   S   + + ++  +       
Sbjct: 256  VLQRK---LEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET 312

Query: 1989 EEPKSLVLAGNVERNIAEGK-EIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERF 2047
            E  +S +L   +E  +AE K   H+L E    LLE+      +     +Q +++      
Sbjct: 313  EREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ------FEQAGQAQAELESRYSAL 366

Query: 2048 FQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEESKM 2107
             QK        + + E  +S + +     + ++ A    K+ +        E+ ++ ++ 
Sbjct: 367  EQK-------HKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQT 419

Query: 2108 VQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLP 2167
            +Q       D+ ++ S E+     R P+      E  S  S     N  TQ  V + ++ 
Sbjct: 420  IQQL----EDQLQQKSKEISQFLNRLPLQQ---HETASQTSFPDVYNEGTQA-VTEENIA 471

Query: 2168 EEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNF 2227
              +  K +   ++   +L   S   +   AE E L +Q        +T+++ +       
Sbjct: 472  SLQ--KRVVELENEKGALLLSSIELEELKAENEKLSSQ--------ITLLEAQNRTGEAD 521

Query: 2228 NVAEKPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSRE 2287
                + +   ++  +  +A+E    ++++   Q  KE S++L  +++ Q+     E++  
Sbjct: 522  REVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQE-----EIA-- 574

Query: 2288 DYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKT---IVPPHVTDSK 2344
             + K ++ G   E   + V+   + + +E +  + I  K+ +E+      ++P   +   
Sbjct: 575  -FLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLP 633

Query: 2345 RVQKPAIAPP--SKWNISIFKEEPRSDQKQ------KSLLSF--------DVVDKVPQQP 2388
             V+K   +    S+ +  I   +   + K       KSL +         D ++++  Q 
Sbjct: 634  AVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI 693

Query: 2389 KSASSNFAS------KNITKESEKPESIILPVEESK-------GSLIDFSEDRLK----- 2430
                 NF        KN+ +++++  ++   +EE K        +    SE+R +     
Sbjct: 694  LELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753

Query: 2431 KEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLELRDS-- 2488
            KE+   T L+   ++ ++ +++  E++  L+  S T A   +L E+ +S++ +E +    
Sbjct: 754  KELSMVTELRAQVKQLEM-NLAEAERQRRLDYESQT-AHDNLLTEQIHSLS-IEAKSKDV 810

Query: 2489 ------NEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNERPKIIVGSEKEKGEEKE 2542
                  NE+   Q+    +ST ++            Q++  N+  +++ G+E+ +     
Sbjct: 811  KIEVLQNELDDVQLQFSEQSTLIRS----------LQSQLQNKESEVLEGAERVR--HIS 858

Query: 2543 NQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVKATSVTEKSEAML 2602
            ++V  LS+   Q+E +   ++      +    +L  ++ E       K   VTE S +M 
Sbjct: 859  SKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEE-------KDQQVTEISFSMT 911

Query: 2603 AEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQEGNLVLEKS 2662
             +      E  ++G +   L+E   L           LS  +E +   + ++  +     
Sbjct: 912  EKMVQLNEEKFSLGVEIKTLKEQLNL-----------LSRAEEAKKEQVEEDNEV----- 955

Query: 2663 SRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLEESKVLVEKTKT 2722
                   S  K+ +   E+S  G   I+KE ++  F       + R  +    L+ + K 
Sbjct: 956  ------SSGLKQNY--DEMSPAGQ--ISKEELQHEFDLLKKENEQRKRKLQAALINR-KE 1004

Query: 2723 FLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVDITKESM 2782
             L  V    +E+ N  L  E    +  S  +  +  E+KE  + SE          +  +
Sbjct: 1005 LLQRVSRLEEELAN--LKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL 1062

Query: 2783 KEGFPSKESE-RTLARPFDETKSSETPPYLLSPVKPQTLASGASPEINAVKKKEMPRSEL 2841
            K+    KE E + + +  +E  ++E     L     QTL        +   + ++ ++E+
Sbjct: 1063 KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ-------DKTNQIDLLQAEI 1115

Query: 2842 TPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSA 2901
            +  +  +  + TS  D SD    SV + K      E   +  P + +  ++   +     
Sbjct: 1116 SENQAIIQKLITSNTDASD--GDSVALVK------ETVVISPPCTGSSEHWKPELE---- 1163

Query: 2902 SNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQKTAFSIISEGCEILNIHAPAF 2961
               +K+++   + KE E    K ++  +TS+ A L + Q+    +  E  +  + +    
Sbjct: 1164 ---EKILA---LEKEKEQLQKKLQE-ALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ 1216

Query: 2962 ISSIDQ-EESEQMQDKLEYLE---EKASFKTIPLPDDSETVACHKTLKSRL----EDEKV 3013
                +Q +E+E + D+L  L+    ++    +P  D  E+ +    L+  L    E    
Sbjct: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276

Query: 3014 TPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTL-IDYNISPDPEKQKA 3072
             P+ E+       +  E ++  +   S  Q     +E   EK  L +  + +     +K+
Sbjct: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336

Query: 3073 PQKLNVEEKLSKEVTE----ETISFPVSSVESALEHEYDLVKLDESFYGPEKGHNILSHP 3128
             +   ++E+++K+  E    +T+S        +L+ + +  +L  +          L H 
Sbjct: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG---------LEHL 1387

Query: 3129 ETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLS-RTQIFPTT--IKVIDPEFLEE 3185
              + Q   D      +K++ D       L E E  +   +T+I      IK +  +   +
Sbjct: 1388 R-ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQ 1446

Query: 3186 PPALAFLYKDLYEEAVGEKKKEEETASEGDSVNS-----EASFPSRNSDTDDGTGIYFEK 3240
                    K L  E    K+K EE   E  +        +A+  SR     +   +  E 
Sbjct: 1447 AKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEEL 1506

Query: 3241 YILKDDILHDT-SLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQK 3299
             + +  I   T SL   +     + K   KD     +A   E   K  T   ++SL E +
Sbjct: 1507 SLARGTIERLTKSLADVESQVSAQNKE--KDTVLGRLALLQEERDKLITEM-DRSLLENQ 1563

Query: 3300 GVYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHVLERADEAGSHG 3359
             +    ES+     +  +   K+  + E   + + KI+ +  +++ H  L++  E     
Sbjct: 1564 SLSSSCESLKLA--LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQS 1621

Query: 3360 NEVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPSEERLRNS---- 3415
             E  +   E   +V   V   ++E        +    E  K L   E   E ++      
Sbjct: 1622 YENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF 1681

Query: 3416 ------PVQDEYEFTESLHNEVVPQDILSEE-----LSSESTPEDVLSQGKESFEHISEN 3464
                   + +  E  + L  EV P    ++E     LSS ++ ++ L + K  +E +S+ 
Sbjct: 1682 AKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKK 1741

Query: 3465 EFASEAEQSTPAEQ-------------KELGSERKEEDQLSSEVVTEKAQK-----ELKK 3506
              +  +E+ + +E+             K+   E  E+    + V  E  Q      E + 
Sbjct: 1742 FQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQD 1801

Query: 3507 SQIDTYCYTC-------KCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEK 3559
            S   +   TC       K    A  K F +H +     ++  +  +  QL E +  L+E+
Sbjct: 1802 SLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE-----INNYLQQID-QLKERIAGLEEE 1855

Query: 3560 SLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMK----------------KVLAQY 3603
              + + F   +E+  NT+    S  +  L+   EE+ K                K+    
Sbjct: 1856 KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915

Query: 3604 DEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINE 3663
            +E+    EE    ++  L+  + ++ Q +  A+   E +  E + L + V  +  EE  +
Sbjct: 1916 EEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCV--SELEEEKQ 1973

Query: 3664 RLLSA------------MESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLE 3711
            +L+              +E     +K P   S  +   +      Q +KQ+   Q   + 
Sbjct: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL---QKDCIR 2030

Query: 3712 PQEPNSATSTTI 3723
             QE  SA   T+
Sbjct: 2031 YQEKISALERTV 2042



 Score = 39.7 bits (91), Expect = 0.062
 Identities = 85/473 (17%), Positives = 179/473 (37%), Gaps = 74/473 (15%)

Query: 3328 DVRVATQKISYAVPFEDTHHVLERADEAGSHGNEV------------GNASPEVNLNVPV 3375
            ++ VA +K+S+    E+ HH+LE+ ++AG    E+                 + +  + +
Sbjct: 325  ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSL 384

Query: 3376 QVSFPEEEFASGATHVQETSLEEPKI--LVPPEPSEERLRNSPVQDEYEFTESLHNEVVP 3433
            Q +  E + A  A   Q + L + K    V    + ++L +   Q   E ++ L+   + 
Sbjct: 385  QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ 444

Query: 3434 QDILSEELSSESTPEDVLSQGKESFEHISENEFASEAEQSTPAEQK---------ELGSE 3484
            Q     E +S+++  DV ++G ++   ++E   AS  ++    E +         EL   
Sbjct: 445  Q----HETASQTSFPDVYNEGTQA---VTEENIASLQKRVVELENEKGALLLSSIELEEL 497

Query: 3485 RKEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISA 3544
            + E ++LSS++   +AQ    ++  +    +    +   +K   + ++     L+   S 
Sbjct: 498  KAENEKLSSQITLLEAQNRTGEADREVSEISI---VDIANKRSSSAEESGQDVLENTFSQ 554

Query: 3545 VKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYD 3604
               +L+  L  ++E    I     +++              KR EE + E    VL Q +
Sbjct: 555  KHKELSVLLLEMKEAQEEIAFLKLQLQG-------------KRAEEADHE----VLDQKE 597

Query: 3605 EKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINER 3664
             K    E +   KM+   E        M   + +L  + +E          T  +     
Sbjct: 598  MKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAS-------TEHQSRTSE 650

Query: 3665 LLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPNSATSTTIA 3724
             +S  ++   L+               S + D      AVP   +    E     S  + 
Sbjct: 651  EISLNDAGVELK---------------STKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695

Query: 3725 VYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDR 3777
            +  + +K   I  ++    E+ ++   +N+L+EE++     +   F  L  +R
Sbjct: 696  LELNFHKAQEI--YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746


>gi|62865606 tripartite motif-containing 36 isoform 1 [Homo sapiens]
          Length = 728

 Score = 78.2 bits (191), Expect = 2e-13
 Identities = 67/310 (21%), Positives = 140/310 (45%), Gaps = 20/310 (6%)

Query: 3503 ELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLR 3562
            E +  +I+ YC  C+ P+    K+ G H +H V+T+ +A   +K +L++ ++ L  K  +
Sbjct: 214  EHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQ 273

Query: 3563 IEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLH 3622
            +++ +SE+       E N  + ++      E++ + +  +     ++ +  KK +++   
Sbjct: 274  VKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQ 333

Query: 3623 EQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAF 3682
             QM  + Q +      +       +E D++ F+ + ++++ R+  A ES  S    PAA 
Sbjct: 334  TQMEEY-QGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFR--PAAQ 390

Query: 3683 SLFEHYDDSSARSDQMLKQVA-------VPQPPRLEPQEPNSATSTTIAVYWSMNKEDVI 3735
            + FE Y  ++++  ++L +++       VP     E  E  S       + W   ++D  
Sbjct: 391  TSFEDYVVNTSKQTELLGELSFFSSGIDVP-----EINEEQSKVYNNALINWHHPEKDKA 445

Query: 3736 DSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPS 3795
            DS+ +   +  +DD+     +    + V  +  I +DLE    Y   V A   + CS  S
Sbjct: 446  DSYVLEYRKINRDDE-----MSWNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCS 500

Query: 3796 ERAIFRTAPS 3805
               I  T P+
Sbjct: 501  RELILHTPPA 510



 Score = 34.7 bits (78), Expect = 2.0
 Identities = 62/305 (20%), Positives = 115/305 (37%), Gaps = 46/305 (15%)

Query: 3793 LPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEYCRQHSPEGEGLR 3852
            L  E + F +    P I  E   V +N A I W     +  ++Y LEY + +  +     
Sbjct: 406  LLGELSFFSSGIDVPEINEEQSKV-YNNALINWHHPEKDKADSYVLEYRKINRDDEMSWN 464

Query: 3853 SFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGT---RFLLLRETAHP 3909
                    ++  +L+ +  Y F VRA      S  S   ++ T       FL   +  + 
Sbjct: 465  EIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYN 524

Query: 3910 ALHI----------SSSG-TVISFGERRRL---TEIPSVLGEELPSCGQHYWETTVTDCP 3955
              H+          S +G  ++   ER ++   T +  ++G+   + G+H+W   V    
Sbjct: 525  NEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYS 584

Query: 3956 -AYRLGICSSSAVQ--------AGALGQGETSWYMHCSE------PQRYTFFYSGIVS-- 3998
               ++G+ SS  +Q        A +    + S +   SE       Q +T    G+    
Sbjct: 585  YLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFF 644

Query: 3999 -----------DVHVTERPARVGILLDYNNQRLIFINAESEQLLFIIRHRFNEGVHPAFA 4047
                       +  V   P  +GI LD +  ++ F + +  + L+  +   +  ++PAFA
Sbjct: 645  IPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFA 704

Query: 4048 LEKPG 4052
            L   G
Sbjct: 705  LMGSG 709


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 148/676 (21%), Positives = 252/676 (37%), Gaps = 95/676 (14%)

Query: 1947 LPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAE 2006
            +P  +    + S+E +  ++ S   T  +  ++   EE ++ EE   +      E    E
Sbjct: 429  IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT---EETQVTEE---VTEEEEKEAKEEE 482

Query: 2007 GKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETIS 2066
            GKE     E E+               E  +E+ K PP      P         + E  S
Sbjct: 483  GKEEEGGEEEEA---------------EGGEEETKSPPAEEAASP---------EKEAKS 518

Query: 2067 SSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPL-EESKMVQSKVIDDADEGKKPSPE 2125
               + A  PAE   P     K       P   + P  EE+K        + +E K P+ E
Sbjct: 519  PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA-E 577

Query: 2126 VKIPTQRKPISSIHAREPQSPESPEVTQNPPTQ----PKVAKPDLPEE-KGKKGISSFKS 2180
            VK P + K  +   A+ P   +SPE  ++P  +    P  AK  + EE K    + S + 
Sbjct: 578  VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637

Query: 2181 WMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSE 2240
              S     + +P+   A+  + E   SP  EKA + +  E   P       K    S  +
Sbjct: 638  AKSPTKEEAKSPEK--AKSPEKEEAKSP--EKAKSPVKAEAKSPEKAKSPVKAEAKSPEK 693

Query: 2241 VKLKTADEPRG-TLVKSGDGQNVKEKSMILSNV-EDLQQPKFISEVSREDYGKKEISGDS 2298
             K    +E +     KS   +  K      S V E+ + P+      +E+    E +   
Sbjct: 694  AKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753

Query: 2299 EEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWN 2358
            E+            + L+++S           EAKT         +  + PA   P K  
Sbjct: 754  EK-----------AKTLDVKS----------PEAKT------PAKEEARSPADKFPEKAK 786

Query: 2359 ISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESIILPVEESK 2418
             S  KEE +S +K KS L  D   K P+  K        K+  KE EKP+ + +     K
Sbjct: 787  -SPVKEEVKSPEKAKSPLKEDA--KAPE--KEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841

Query: 2419 GSLIDFSEDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQN 2478
                        +E + P + K  E++   +  +P +     E     + EKK  A ++ 
Sbjct: 842  A-----------EEEKAPATPKTEEKKDSKKEEAPKK-----EAPKPKVEEKKEPAVEKP 885

Query: 2479 SVAPLELRDSNEIGKTQITLGSRSTELK-ESKADAMPQHFYQNEDYNERPKIIVGSEKEK 2537
              + +E +      K ++    +    K E K DA P+   + E   + P      E  K
Sbjct: 886  KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKE--KTEVAKKEPDDAKAKEPSK 943

Query: 2538 GEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVKATSVTEK 2597
              EK+       + K+++  +P      E+ ++E D +L     + ++    K++S T++
Sbjct: 944  PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS-TDQ 1002

Query: 2598 SEAMLAEAHPEIREAK 2613
             ++   E   E + AK
Sbjct: 1003 KDSKPPEKATEDKAAK 1018



 Score = 73.9 bits (180), Expect = 3e-12
 Identities = 133/627 (21%), Positives = 236/627 (37%), Gaps = 71/627 (11%)

Query: 1094 PEIPTTSTSVS-----EYLILAQKQKTQAYLEPESEDL-IPSHLTSEVEKGEREASSSVA 1147
            P+IP+ ST +      +  ++ + +K    +E ++E+  +   +T E EK  +E      
Sbjct: 427  PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK-- 484

Query: 1148 AIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKE 1207
                    +    +EE +     +  P +  A   E+E  + +  +A     A S  ++E
Sbjct: 485  -------EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEE 537

Query: 1208 EIVPDSQEATAHVSQDQKMEPQ-PPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSEL 1266
               P   ++        K E + PP     E + +  P  V  P+K   P        E 
Sbjct: 538  AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSP------AKEE 591

Query: 1267 EQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQ 1326
             +       PE  K  SP+KE + S  EA S VK E K  +++ +       A S  +++
Sbjct: 592  AKSPAEAKSPEKAK--SPVKEEAKSPAEAKSPVKEEAKSPAEVKSP----EKAKSPTKEE 645

Query: 1327 VEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRP 1386
             +   P  A S   EE K      S     S  K ++      K  +  ++        P
Sbjct: 646  AKS--PEKAKSPEKEEAK------SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697

Query: 1387 VLTKVGKGELGSGLPPLVTSADEH--SVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIK 1444
            V  +    E           + E   S + EE K   K  SP++  +K    +++ ++ K
Sbjct: 698  VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757

Query: 1445 FDSL--PSVSSIAEHSVLSEVEAKEVKAGLPV---IKTSSSQHSDKSEEARVEDKQ---- 1495
               +  P   + A+    S  +    KA  PV   +K+     S   E+A+  +K+    
Sbjct: 758  TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817

Query: 1496 DLLFSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKK--KETELPSSQNVSPA 1553
            + + S V + E+    + K     +E    E + P +   E KK  K+ E P  +   P 
Sbjct: 818  EEVKSPVKEEEKPQEVKVKEPPKKAE----EEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873

Query: 1554 SKH----IIPKGKDEETASSSPELENLASGLAPT------LLLLSDDKNKPAVEVSSTAQ 1603
             +      + K K+ +  +   E E+      P       + +  D K K   EV+    
Sbjct: 874  VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933

Query: 1604 GDFPSEKQDVALAELSLEPEKKD----KPHQPLELPNAGSEFSSD---LGRQ-SGSIGTK 1655
             D  +++      +    PEKKD    K  +P E P   ++   D   L ++ S     K
Sbjct: 934  DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEK 993

Query: 1656 QAKSPITETEDSVLEKGPAELRSREGK 1682
              KS  T+ +DS   +   E ++ +GK
Sbjct: 994  AEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 73.2 bits (178), Expect = 5e-12
 Identities = 141/617 (22%), Positives = 220/617 (35%), Gaps = 72/617 (11%)

Query: 1148 AIPAALPAQSSI-----VKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALS 1202
            ++P  LP   S+     VK E K         ++V   ++ +E      +   +E+ A  
Sbjct: 421  SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480

Query: 1203 KVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNV 1262
            +  KEE   + +EA     + +    +    PE E K  V     +E K   + K     
Sbjct: 481  EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK----EEAKSPAEAK----- 531

Query: 1263 TSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITT-----TPIVLH 1317
            + E E+ K         K  SP KE + S PEA S  K E K  +++ +     +P    
Sbjct: 532  SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 591

Query: 1318 SASSGVEKQVEHG---------PPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRA 1368
            + S    K  E            PA A S + EE K   E  S     S TK ++     
Sbjct: 592  AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651

Query: 1369 VKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPLVTSADE--HSVLAEEDKVAIKGASP 1426
             K     ++        PV  +    E           + E   S + EE K   K  SP
Sbjct: 652  AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711

Query: 1427 I--ETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSD 1484
            +  E  S   A S  ++E K     + S + E +   E      KA    +K+  ++   
Sbjct: 712  VKEEAKSPEKAKSPVKEEAKTPE-KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770

Query: 1485 KSEEARVEDK-QDLLFSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETE 1543
            K E     DK  +   S V   E + S +K       +   PE E+P       KK+E +
Sbjct: 771  KEEARSPADKFPEKAKSPV--KEEVKSPEKAKSPLKEDAKAPEKEIP-------KKEEVK 821

Query: 1544 LPSSQNVSPASKHI--IPKGKDEETASSSPELENLASGL---APTLLLLSDDKNKPAVEV 1598
             P  +   P    +   PK  +EE A ++P+ E         AP       +  KP VE 
Sbjct: 822  SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP-----KKEAPKPKVEE 876

Query: 1599 SSTAQGDFPSEKQDVALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAK 1658
                  + P E +  A  E +   +KK  P    E P                +  K+  
Sbjct: 877  KKEPAVEKPKESKVEAKKEEA--EDKKKVPTPEKEAP--------------AKVEVKEDA 920

Query: 1659 SPITETEDSVLEKGPAELRSRE-GKEENRELCASSTMPAISELSSLLREESQNEEIKPFS 1717
             P  +TE  V +K P + +++E  K   ++  A        E +    E+ + E      
Sbjct: 921  KPKEKTE--VAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978

Query: 1718 PKIISLESKEPPASVAE 1734
             K +S E  +P A  AE
Sbjct: 979  DKTLSKEPSKPKAEKAE 995



 Score = 68.9 bits (167), Expect = 9e-11
 Identities = 187/854 (21%), Positives = 304/854 (35%), Gaps = 172/854 (20%)

Query: 417  SFANEVKKEDVYSAHHSIS-----LEAASPGLAA--STQDGLD------PDQEQPDLTSI 463
            S A +V  + + SA   I+     L+A +  L A  ST+D L+       D+ Q D+ S 
Sbjct: 301  SEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASY 360

Query: 464  ERA-EPVSAKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPE 522
            + A + + A+L  T   +  +                + E  +   ++ +L I I    +
Sbjct: 361  QEAIQQLDAELRNTKWEMAAQ----------------LREYQDLLNVKMALDIEIAAYRK 404

Query: 523  DSNLVEEEIVELDYPESPLVSEKPFP--PHMSPEVEHKEEELILPLLAASSPEHVALSEE 580
               L+E E   + +   P    +  P  P +S  ++ K EE I   +   S +   + EE
Sbjct: 405  ---LLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIK--VVEKSEKETVIVEE 459

Query: 581  EREEIASVSTGSAFVSEYSVPQDLNHELQEQEG-----------EPVPPSNVEAIAEHAV 629
            + EE          V+E    +    E +E+EG           E   P   EA +    
Sbjct: 460  QTEETQVTEE----VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKE 515

Query: 630  LSEEENEEFEAYSPAAAPTSESSLSPSTTEKTSENQSPLFSTV--TPEYMVLSGDEASES 687
                  EE ++ + A +P  E + SP+  +   + +SP        PE      +EA   
Sbjct: 516  AKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAK-- 573

Query: 688  GCYTPDSTSASEYSVPSLA---TKESLKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTP 744
                    S +E   P  A    KE  K   + KSP   K        S  KE+  S   
Sbjct: 574  --------SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK--------SPVKEEAKSPAE 617

Query: 745  AVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAP 804
            A +P  E + SP+  +   + +SP    A S     S  ++        ++K   K  +P
Sbjct: 618  AKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE--------EAKSPEKAKSP 669

Query: 805  LNATQESQKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHT-TEM 863
            + A  +S +K     S  K +  S     S   +E   P      V  E   P    + +
Sbjct: 670  VKAEAKSPEK---AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV 726

Query: 864  TSECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSL 923
              E + P  + +P +    S E+A      +P      +   P   TP A+EE       
Sbjct: 727  KEEAKTPEKAKSPVKEEAKSPEKA-----KSPEKAKTLDVKSPEAKTP-AKEEARSPADK 780

Query: 924  NLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSE 983
              + A SP+      +E   P    S    +   P    +E  K+E E  SP        
Sbjct: 781  FPEKAKSPVK-----EEVKSPEKAKSPLKEDAKAP---EKEIPKKE-EVKSP-------- 823

Query: 984  HTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADE 1043
              +  +E  +E ++  P   ++    P     T K E + DS                 E
Sbjct: 824  --VKEEEKPQEVKVKEPPKKAEEEKAP----ATPKTEEKKDS---------------KKE 862

Query: 1044 EDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSV 1103
            E     A  P  E+    +K+ A   P  S +E         K E+AE K ++PT     
Sbjct: 863  EAPKKEAPKPKVEE----KKEPAVEKPKESKVE--------AKKEEAEDKKKVPT----- 905

Query: 1104 SEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEE 1163
                    +++  A +E + ED  P   T   +K   +A +   + PA           E
Sbjct: 906  -------PEKEAPAKVEVK-EDAKPKEKTEVAKKEPDDAKAKEPSKPA-----------E 946

Query: 1164 TKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQD 1223
             K A+P         A K E++P      K  D+ ++     KE   P +++A    S D
Sbjct: 947  KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLS-----KEPSKPKAEKAEKSSSTD 1001

Query: 1224 QKMEPQPPNVPESE 1237
            QK    P    E +
Sbjct: 1002 QKDSKPPEKATEDK 1015



 Score = 62.4 bits (150), Expect = 9e-09
 Identities = 120/585 (20%), Positives = 219/585 (37%), Gaps = 70/585 (11%)

Query: 2962 ISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVACHKTLKSRLEDEKVTPLKENKQ 3021
            I S+      + ++K++ +E+      I      ET    +  +   E+EK    +E K+
Sbjct: 429  IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTE---EEEKEAKEEEGKE 485

Query: 3022 KETHKTKEEISTDSETDLSFIQPTIPSEED----YFEKYTLIDYNISPDPEKQKAPQKLN 3077
            +E  + +E    + ET     +     E++      E+        SP+ E+ K+P ++ 
Sbjct: 486  EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545

Query: 3078 VEEKLSKEVTEETISFP-VSSVESALEHEYDLVKLDESFYGPEKGHNILSHPETQSQNSA 3136
              EK      EE  S P   S E         VK  E    P K     S  E +S   A
Sbjct: 546  SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK-EEAKSPAEAKSPEKA 604

Query: 3137 DRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQI-FPTTIKVIDPEFLEEPPALAFLYKD 3195
               V ++ K   ++KSP     ++   V S  +   PT  +   PE  + P         
Sbjct: 605  KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP--------- 655

Query: 3196 LYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGTGIYFEKYILKDDILHDTSLTQ 3255
                   EK++ +        V +EA  P +            EK   K  +  +    +
Sbjct: 656  -------EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK--AKSPVKEEAKSPE 706

Query: 3256 KDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQKGVYGEGESVDHVETVG 3315
            K +    EE +   + +  P+  E +   K  +  +E++   +K      +S +  +T+ 
Sbjct: 707  KAKSPVKEEAK-SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA-----KSPEKAKTLD 760

Query: 3316 NVAMQKKAPITEDVRVATQKISYAV--PFEDTHHVLERA-----DEAGSHGNEVGNA--- 3365
              + + K P  E+ R    K       P ++     E+A     ++A +   E+      
Sbjct: 761  VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820

Query: 3366 -SP--------EVNLNVPVQVSFPEEEFASGATHVQETSLEE---------PKILVPPEP 3407
             SP        EV +  P + +  E+  A+  T  ++ S +E         PK+    EP
Sbjct: 821  KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEP 880

Query: 3408 SEERLRNSPVQDEYEFTESLHNEVVPQDILSE--ELSSESTPEDVLSQGKESFEHISENE 3465
            + E+ + S V+ + E  E       P+       E+  ++ P++     K+      E +
Sbjct: 881  AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK------EPD 934

Query: 3466 FASEAEQSTPAEQKELGSERKEEDQLSSEVVTEKAQKELKKSQID 3510
             A   E S PAE+KE   E+K+  +  ++   EK + E K  + D
Sbjct: 935  DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 136/675 (20%), Positives = 256/675 (37%), Gaps = 70/675 (10%)

Query: 2442 SEEETKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPL--ELRDSNEIGKTQITLG 2499
            S +++  R  S  E +   +  SY  A +++ AE +N+   +  +LR+  ++   ++ L 
Sbjct: 337  STKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALD 396

Query: 2500 ------SRSTELKESKADAMPQHFYQNEDYNERPKIIVGSEKEKGEEKENQVYVLSEGKK 2553
                   +  E +E +    P  F   E   + P +     K K EEK   + V+ + +K
Sbjct: 397  IEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHI-KVKSEEK---IKVVEKSEK 452

Query: 2554 QQ---EHQPYSVNVAESMSRESDISLGHSLG-ETQSFSLVKATSVTEKSEAMLAE--AHP 2607
            +    E Q     V E ++ E +       G E +     +A    E++++  AE  A P
Sbjct: 453  ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASP 512

Query: 2608 EIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQEGNLVLEKSSRDMP 2667
            E +EAK+      P++E      + K+  P     +   E  S  +  +   E++     
Sbjct: 513  E-KEAKS------PVKEEAKSPAEAKS--PEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563

Query: 2668 DHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLEESKVLVEKTKTFLPVV 2727
              S EKE+ +     K  S +  K   K+  +  A    P          EK K+  PV 
Sbjct: 564  AKSPEKEEAKSPAEVK--SPEKAKSPAKEEAKSPAEAKSP----------EKAKS--PVK 609

Query: 2728 LSCHDEIENHS-LSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVDITKESMKEGF 2786
                   E  S + +E     E  S +    S  KE+ K  E  K    +  K   K   
Sbjct: 610  EEAKSPAEAKSPVKEEAKSPAEVKSPEKAK-SPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668

Query: 2787 PSKESERTLARPFDETKS-SETPPYLLSPVKPQTLA--SGASPEINAVKKKEMPRSELTP 2843
            P K   ++  +     K+ +++P    SPVK +  +     SP     K  E  +S +  
Sbjct: 669  PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 2844 ERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSASN 2903
            E  T    ++   + +  P+++    K      +    K P      + A      + S 
Sbjct: 729  EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788

Query: 2904 ADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQKTAFSIISEGCEILNIHAPAFIS 2963
              + V + E  K P    AK  +  +  K     E+ K+      +  E+     P    
Sbjct: 789  VKEEVKSPEKAKSPLKEDAKAPEKEIPKK-----EEVKSPVKEEEKPQEVKVKEPPKKAE 843

Query: 2964 SIDQEESEQMQDKLEYLEEKASFKTIPLP--DDSETVACHKTLKSRL-------EDEKVT 3014
                  + + ++K +  +E+A  K  P P  ++ +  A  K  +S++       ED+K  
Sbjct: 844  EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903

Query: 3015 PLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLIDYNISPDPEKQKAPQ 3074
            P  E +     + KE+     +T+++  +P     ++             P  +K+ AP+
Sbjct: 904  PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE----------PSKPAEKKEAAPE 953

Query: 3075 KLNVEEKLSKEVTEE 3089
            K + +E+ +K+  E+
Sbjct: 954  KKDTKEEKAKKPEEK 968



 Score = 36.6 bits (83), Expect = 0.52
 Identities = 107/542 (19%), Positives = 195/542 (35%), Gaps = 77/542 (14%)

Query: 16  SDGDEEATRELETEEESEGEEDETAAESEE---EPDSRLSDQDEEGKIKQEYIISDPSFS 72
           ++ +E+  +E E +EE  GEE+E     EE    P    +  ++E K   +     P+ +
Sbjct: 471 TEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA 530

Query: 73  MVTVQREDSGITWETNSSRSSTPWASEESQTSGVCSREGSTVNSPPGNVSFIVDEVKKVR 132
               + E        +  ++ +P   E        S E     SP         EVK   
Sbjct: 531 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA--------EVKSPE 582

Query: 133 KRTHKSKH--GSPSLRRKGNRKRNSFESQDVPTNKKGSPL----TSASQVLTTEKEKSYT 186
           K    +K    SP+  +   + ++  + +     +  SP+     S ++V + EK KS T
Sbjct: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642

Query: 187 GIYDKARKK-----KTTSNTPPITGAIYKEH--KPLVLRPVYIGTVQYKIKMFNSVKEEL 239
               K+ +K     K  + +P    +  K     P   +       +   K  + VKEE 
Sbjct: 643 KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE- 701

Query: 240 IPLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEV 299
                          K     K      +  P+   S     +KT +     ++++ K  
Sbjct: 702 --------------AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS- 746

Query: 300 FPPWRGALSKGSESLTLMFSH-----EDQKKIYADS-PLNATSALEHTVPSYSSSGRAEQ 353
             P +    + +++L +         +++ +  AD  P  A S ++  V S   +    +
Sbjct: 747 --PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804

Query: 354 GIQLRHSQSVPQQPE------DEAKPHEV---EPP-----SVTPDTPATMFLRTTKEE-- 397
                  + +P++ E      +E KP EV   EPP        P TP T   + +K+E  
Sbjct: 805 EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA 864

Query: 398 --CELASPGTAASENDSSVSPSFAN-EVKKEDVYSAHHSISLEAASPGLAASTQDGLDPD 454
              E   P     +  +   P  +  E KKE+          +  +P   A  +  +  D
Sbjct: 865 PKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED-----KKKVPTPEKEAPAKVEVKED 919

Query: 455 QEQPDLTSIERAEPVSAKL-TPTHPSVK----GEKEENMLEPSISLSEPLMLEEPEKEEI 509
            +  + T + + EP  AK   P+ P+ K     EK++   E +    E    E   KE+ 
Sbjct: 920 AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979

Query: 510 ET 511
           +T
Sbjct: 980 KT 981


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 287/1441 (19%), Positives = 531/1441 (36%), Gaps = 193/1441 (13%)

Query: 743  TPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSE-----------GEDLGSERF 791
            T  V   S  S S    ++TS  +   P    S+   P +           G      + 
Sbjct: 663  TAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQ 722

Query: 792  TPDSKLISKYAAPLNAT--QESQKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLV 849
             P++  +SK A P   +   E  K  + +    +PK +   T L         P  P   
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782

Query: 850  V---ASEHSFPPHTTEMTSECQAPP-----LSATPSEYVVLSDEEAVELERYTPSSTSAS 901
            V   A E + PP  T+     Q+ P     +S   S+ +     ++  +    PSS S  
Sbjct: 783  VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKG 842

Query: 902  EFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPYA 961
            +  V P    E  E +     ++ K  + PM           P +  +    + S  P  
Sbjct: 843  QKQVDPVQKKE--EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKP-- 898

Query: 962  TQEAEKREFEC------DSPICLTSPSEHTILSDEDTEEAELFS-------------PDS 1002
              + + R F        D+P    +  + T+        A +FS             P S
Sbjct: 899  --QEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHS 956

Query: 1003 ASQVSIPPFRI---SETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFS 1059
             S    P  +    S+   ++  P S   A  A   S   + + +   +    P +EQ  
Sbjct: 957  QSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016

Query: 1060 SSQKQKAETFPLMSPLEDL-SLPPSTDKS---EKAEIKPEIPTTSTSVSEYLILAQKQKT 1115
            + ++ + E  P   P++D  SL     K+    K E  P+  +T       L +  K   
Sbjct: 1017 TVKRTETEKKP--PPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPP 1074

Query: 1116 QAYLEPESEDLIPS--------HLTSEVE------KGEREASSSVAAIPAALPAQS---- 1157
                  E ++ + +        HLT   E      + +R  S  +  I    PA S    
Sbjct: 1075 NFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKA 1134

Query: 1158 SIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEAT 1217
            S +   T+ +S  + +P  V  +KK+++      +K   E++ L KV++       ++  
Sbjct: 1135 SPMPVPTESSSQKTAVPPQVKLVKKQEQE-----VKTEAEKVILEKVKE---TLSMEKIP 1186

Query: 1218 AHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPE 1277
              V+ DQK E       ES+++      + ++     + KL+       E++  S+ +  
Sbjct: 1187 PMVTTDQKQE-------ESKLEKDKASALQEKKPLPEEKKLIPE-----EEKIRSEEKKP 1234

Query: 1278 VIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFS 1337
            +++   P  E     PEA ++   E KHD        +L S     E+++E G  A    
Sbjct: 1235 LLEEKKPTPEDKKLLPEAKTSAPEEQKHD--------LLKSQVQIAEEKLE-GRVAPKTV 1285

Query: 1338 ALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEE----IPTDSSLITPVDRPVLTKVGK 1393
               ++ + ++E   S T  S+ K D   T+ +KE+           + P       +  K
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDK 1345

Query: 1394 GELGSGLPPLVTSADEHSVLAEEDKVAIKGASP--IETSSKHLAWSEAEKEIKFDSLPSV 1451
             +  S   P        +  + +   +  G  P  I T  K +      K +K DS    
Sbjct: 1346 SDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDIL-----KGLKKDSFSQE 1400

Query: 1452 SSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSS 1511
            SS +  S L+++E+      L +++  +S  +D+  E + +  +      V   +     
Sbjct: 1401 SSPSSPSDLAKLESTV----LSILEAQASTLADEKSEKKTQPHE------VSPEQPKDQE 1450

Query: 1512 QKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGK--DEETASS 1569
            + +SL  T E+   E E+  S   + ++K+T    SQ   P+SK    K +  D+ T   
Sbjct: 1451 KTQSLSETLEITISEEEIKES---QEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRR 1507

Query: 1570 SPE---LENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKD 1626
             P     E+  S  +P        + K    V S++  ++  E    +        E++D
Sbjct: 1508 EPYDSVEESSESENSPV------PQRKRRTSVGSSSSDEYKQEDSQGS-------GEEED 1554

Query: 1627 KPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENR 1686
               + +   +A  + S   G +       Q K   + TE    E+   + +   GK  +R
Sbjct: 1555 FIRKQIIEMSADEDAS---GSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGK--HR 1609

Query: 1687 ELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPAS---VAEGGNPEEFQP 1743
             L   S+     +         +++E    SP++   E+K   +    V  GG    F+ 
Sbjct: 1610 RLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKT 1669

Query: 1744 FTFSLKGLSEEVSHPADFKKGG-----NQEIGPLPPTGNLKAQVMGDILDKLSEETGHPN 1798
               +   ++++ S  +  KK         E+     T + + +  G+    L   +  P 
Sbjct: 1670 IELN-STIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPG 1728

Query: 1799 SSQV-LQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSED----KQDLGIKQ 1853
            +S   + S+ E S  +PS    E K+  KA H      LP +  SSE+    +++  +K+
Sbjct: 1729 TSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKE 1788

Query: 1854 FSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGS 1913
                RE +  +Q KS       D  E + +     PK     L   E+ +   E R A  
Sbjct: 1789 QEKQRE-IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAE 1847

Query: 1914 V-QLDSSSSNELRP---GQLKAAVSSKDHTCEVRK--------QVLPHSAEESHLSSQEA 1961
            + +L  SS +E  P      +    S +   EV+K         +   + E+S +  + +
Sbjct: 1848 MEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGS 1907

Query: 1962 VSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLV----LAGNVERNIAEGKEIHSLMES- 2016
              AL ++    E +  K++  +    A E   +     L G +   + E     SL+E  
Sbjct: 1908 QKALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGM---LIEDYIYESLVEDT 1964

Query: 2017 -----ESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKP---VSGLSVEQVKSETISSS 2068
                 +  LL +   E  +  ++  ++KI+L  E+ ++ P   ++ L  E  + E++ S 
Sbjct: 1965 YNGSVDGSLLTRQEEENGFMQQKGREQKIRL-SEQIYEDPMQKITDLQKEFYELESLHSV 2023

Query: 2069 V 2069
            V
Sbjct: 2024 V 2024



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 380/1955 (19%), Positives = 693/1955 (35%), Gaps = 278/1955 (14%)

Query: 439  ASPGLAAS-TQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSVKGEKEENMLEPSISLSE 497
            A PGL+ S T D    +Q+ P  +       +S K + +   +K E + +M+   +S   
Sbjct: 106  AQPGLSKSRTTDTFRSEQKLPGRSP----STISLKESKSRTDLKEEHKSSMMPGFLSEVN 161

Query: 498  PLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSEKPF---PPHMSPE 554
             L        +      I+ +   ++    ++++V+ +  +   + + P    PP   P+
Sbjct: 162  ALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPK 221

Query: 555  VEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQE-- 612
             +    +   PL    +P+ ++  + E+ +     TG         PQ  + +L  Q   
Sbjct: 222  QQGPGRD---PLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDA 278

Query: 613  ------------GEPVPPS-------NVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSL 653
                        GE V PS        ++        +++   E     PA  P   S L
Sbjct: 279  SRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGL 338

Query: 654  SPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVP-SLATKESLK 712
            +    ++    + P+    T +        A      T     +SE   P +LA    + 
Sbjct: 339  TKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG 398

Query: 713  KTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPST 772
            KT  ++         +   P    +  G  +PA AP   P+ +P         Q P P  
Sbjct: 399  KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPG--PTKTP--------VQQPGPGK 448

Query: 773  ATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTV 832
              ++   P +     +    P S+L    A P        K    +    KP   S+   
Sbjct: 449  IPAQQAGPGKTSAQQTGPTKPPSQLPGP-AKPPPQQPGPAKPPPQQPGSAKPP--SQQPG 505

Query: 833  LSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELER 892
             +    +  GP+ P           P     T      P SA PS       + + +   
Sbjct: 506  STKPPPQQPGPAKPS----------PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQST 555

Query: 893  YTPSSTSASEFSVPPYATPEAQE--EEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSA 950
               S T + +   PP  +P A++   + + +++     ++ + L   ++ +    +    
Sbjct: 556  KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQT 615

Query: 951  FVSE---FSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVS 1007
             V     F+  P+ T+  E         +CL    +  +  D     A + S       +
Sbjct: 616  TVCSLCGFNPNPHLTEVKEW--------LCLNCQMKRALGGDL----APVPSSPQPKLKT 663

Query: 1008 IPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQK-- 1065
             P    S   K+  +P        A+     S+A E           +   S S K K  
Sbjct: 664  APVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQP 723

Query: 1066 --AETFPLMSPLEDLSLPPSTDKSEKAEIKPEIP----TTSTSVSEYLILAQKQKTQAYL 1119
              A++    +P ++ S+P   DK+  A+ KP+ P     T+  VS      +     + +
Sbjct: 724  PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKV 783

Query: 1120 EPESEDLIPSHLTSEVEK--------GEREASSSVAAIPAALPAQSSIVKEETKPASPHS 1171
            + ++E+     L ++  K        GE+ +     AIP   PA  S +     P+S  S
Sbjct: 784  QSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR--PASDSKIISHPGPSS-ES 840

Query: 1172 VLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPP 1231
                 V  ++K++EP  A T  +         + K    P     TA   Q      Q P
Sbjct: 841  KGQKQVDPVQKKEEPKKAQTKMSPKPD--AKPMPKGSPTPPGPRPTA--GQTVPTPQQSP 896

Query: 1232 NVPESEMKYSV-LPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETS- 1289
               E   ++S+ L  + D PK   +P        E    KL      +    S L  T+ 
Sbjct: 897  KPQEQSRRFSLNLGSITDAPKS--QP----TTPQETVTGKLFGFGASIFSQASNLISTAG 950

Query: 1290 LSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKEIEP 1349
              GP + S     MK     +  P      S G  K     PPA    A S  +KKE + 
Sbjct: 951  QPGPHSQSGPGAPMKQAPAPSQPP-----TSQGPPKSTGQAPPA---PAKSIPVKKETKA 1002

Query: 1350 SSSTTTASVTKLDSNLTRAVKEEIP---TDSSLIT--PVDRPVLTKVGKG---------- 1394
             ++       +    + R   E+ P    DS  +T  P    + TK+ K           
Sbjct: 1003 PAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062

Query: 1395 ----ELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPS 1450
                 +GS  PP   +  E     +     + G +P    + HL   +    +   +  +
Sbjct: 1063 KTELNIGSKDPPNFNTCTE----CKNQVCNLCGFNP----TPHLTEIQEWLCLNCQTQRA 1114

Query: 1451 VS-SIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLV 1509
            +S  + +   +    +    + +PV   SSSQ +    + ++  KQ+    T  ++E+++
Sbjct: 1115 ISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKT--EAEKVI 1172

Query: 1510 SSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGK---DEET 1566
              + K  +S  ++       P  +  + K++E++L   +  +   K  +P+ K    EE 
Sbjct: 1173 LEKVKETLSMEKI-------PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEE 1225

Query: 1567 ASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLE----P 1622
               S E + L     PT     D K  P  + S+  +      K  V +AE  LE    P
Sbjct: 1226 KIRSEEKKPLLEEKKPT---PEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAP 1282

Query: 1623 EKKDKPHQPLE----LPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRS 1678
            +   +  QP      LP+   +       ++     +Q + P T   D V E G    + 
Sbjct: 1283 KTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQV-EPG----KE 1337

Query: 1679 REGKEENRELCASSTMP------------------AISELSSL-----------LREESQ 1709
            +  KE+++   +SS  P                  ++ E+ SL           L+++S 
Sbjct: 1338 KTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSF 1397

Query: 1710 NEEIKPFSPK-IISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQE 1768
            ++E  P SP  +  LES       A+                L++E S     KK    E
Sbjct: 1398 SQESSPSSPSDLAKLESTVLSILEAQAST-------------LADEKSE----KKTQPHE 1440

Query: 1769 IGPLPPTGNLKAQVMGDILD-KLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKA 1827
            + P  P    K Q + + L+  +SEE       ++ +S  E       D   +Q      
Sbjct: 1441 VSPEQPKDQEKTQSLSETLEITISEE-------EIKESQEERKDTFKKD--SQQDIPSSK 1491

Query: 1828 LHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFI 1887
             H +++  + D++T  E    +   + S   EN P+ Q K   +   +   E K E+   
Sbjct: 1492 DHKEKSEFVDDITTRREPYDSV---EESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQG 1548

Query: 1888 SPKDENW-------MLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQL--KAAVSSKDH 1938
            S ++E++       M    +   S+ ++ I   ++  SSS+   +  +   K  +++  H
Sbjct: 1549 SGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKH 1608

Query: 1939 TCEVRKQ--VLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVL 1996
                RK    +   A   H    E   A D  S   +   +KS  SEE+ +      L  
Sbjct: 1609 RRLTRKSSTSIDEDAGRRHSWHDEDDEAFD-ESPELKYRETKSQESEEL-VVTGGGGLRR 1666

Query: 1997 AGNVERN--IAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSG 2054
               +E N  IA+     S  +  SL  ++   EL   S  DS      P +R   +  S 
Sbjct: 1667 FKTIELNSTIADKYSAESSQKKTSLYFDE-EPELEMESLTDS------PEDRSRGEGSSS 1719

Query: 2055 LSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVID 2114
            L        T  +SV +    ++        E +  R     P    L          I+
Sbjct: 1720 LHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLL--------PTIE 1771

Query: 2115 DADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKG 2174
            D+ E ++   E ++  +++    I  ++ +S            + K  K +L  ++ ++ 
Sbjct: 1772 DSSEEEELREEEELLKEQEKQREIEQQQRKSSSK---------KSKKDKDELRAQRRRER 1822

Query: 2175 ISSFKSWMSSLFFGSSTPD-NKVAEQEDLE----TQPSPSVEKAVTVIDPEGTIPTNFNV 2229
              +  S +S +   S T +  + AE E+L     ++ SPS+E      DPEG   +   +
Sbjct: 1823 PKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIES-----DPEGFEISPEKI 1877

Query: 2230 AEKPADHSL-SEVKLKTADEPRGTLVKSGDGQNVK 2263
             E    + L + V L +  + +  + K G  + +K
Sbjct: 1878 IEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALK 1912



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 281/1444 (19%), Positives = 520/1444 (36%), Gaps = 240/1444 (16%)

Query: 1567 ASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAE-------LS 1619
            +S  P+L+      AP     +  K+ P  + +S  +   P  KQD++ A        L 
Sbjct: 655  SSPQPKLKT-----APVTTTSAVSKSSPQPQQTSPKKDAAP--KQDLSKAPEPKKPPPLV 707

Query: 1620 LEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSR 1679
             +P     P    + P      S     +  S+ ++Q K+P+ + +     K P  ++  
Sbjct: 708  KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKP----KQPKMVKP- 762

Query: 1680 EGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPE 1739
                   +L +SS+     ++ S  + +SQ EE K   P  +  +S +P  S    G  E
Sbjct: 763  -----TTDLVSSSSATTKPDIPSS-KVQSQAEE-KTTPP--LKTDSAKPSQSFPPTG--E 811

Query: 1740 EFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNS 1799
            +  PF       S+ +  PA   K     I    P+   K Q   D + K  E    P  
Sbjct: 812  KVSPFD------SKAIPRPASDSK----IISHPGPSSESKGQKQVDPVQKKEE----PKK 857

Query: 1800 SQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRE 1859
            +Q   S    +K  P            A    QTV  P  S   +++     ++FSL   
Sbjct: 858  AQTKMSPKPDAKPMPKGSPTPPGPRPTA---GQTVPTPQQSPKPQEQS----RRFSLNLG 910

Query: 1860 NLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSS 1919
            ++  +  KS  TT P +    K+  F  S   +   L         H Q   G+    + 
Sbjct: 911  SIT-DAPKSQPTT-PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAP 968

Query: 1920 S-----SNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEA--VSALDTSSGNT 1972
            +     +++  P     A  +   +  V+K+    +AE+    +++A  V   +T     
Sbjct: 969  APSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPP 1028

Query: 1973 ETLSSKSYSSEEVKL--------AEEPKSLVLAGNVERNIA--EGKEIHSLMESESLLLE 2022
                SKS ++E  K         + +P+S       E NI   +    ++  E ++ +  
Sbjct: 1029 PIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCN 1088

Query: 2023 KANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPA 2082
                  + P   + QE + L  +   Q+ +SG   +  K     S  K +  P   V   
Sbjct: 1089 LCGFNPT-PHLTEIQEWLCLNCQT--QRAISGQLGDIRKMPPAPSGPKASPMP---VPTE 1142

Query: 2083 LGNEKEAHRSTPPF-------PEEKPLEESKMVQSKVIDDADEGKKP------SPEVKIP 2129
              ++K A    PP         +E   E  K++  KV +     K P        + +  
Sbjct: 1143 SSSQKTA---VPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESK 1199

Query: 2130 TQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGS 2189
             ++   S++  ++P   E   + +    + +  KP L E+K                   
Sbjct: 1200 LEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKK------------------- 1240

Query: 2190 STPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEP 2249
             TP++K    E   + P                + +   +AE+  +  ++   ++   +P
Sbjct: 1241 PTPEDKKLLPEAKTSAPEEQ---------KHDLLKSQVQIAEEKLEGRVAPKTVQEGKQP 1291

Query: 2250 RGTL--VKSGDGQNV-KEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSV 2306
            +  +  + SG  Q++ KE       +++  QP   ++  + + GK++   + ++ + +S 
Sbjct: 1292 QTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSS 1351

Query: 2307 VTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEP 2366
                  + L    YS  G    + E  +++P   TD K + K           S  +E  
Sbjct: 1352 QQPKSPQGLSDTGYSSDGISSSLGEIPSLIP---TDEKDILK------GLKKDSFSQESS 1402

Query: 2367 RSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESIILPVEESKGSLIDFSE 2426
             S     + L   V+  +  Q  + +   + K        PE    P ++ K        
Sbjct: 1403 PSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQ---PKDQEK-------- 1451

Query: 2427 DRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRS-YTLAEKKVLAEKQNSVAPLEL 2485
                + +     + ISEEE K    S  E+KD  +  S   +   K   EK   V  +  
Sbjct: 1452 ---TQSLSETLEITISEEEIK---ESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITT 1505

Query: 2486 R--------DSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNE---RPKIIVGSE 2534
            R        +S+E   + +    R T +  S +D   Q   Q     E   R +II  S 
Sbjct: 1506 RREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSA 1565

Query: 2535 KEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGH-SLGETQSFSLVKATS 2593
             E     E+  ++ ++ K+         +  ES  +E     G  + G+ +  +   +TS
Sbjct: 1566 DEDASGSEDDEFIRNQLKEIS-------SSTESQKKEETKGKGKITAGKHRRLTRKSSTS 1618

Query: 2594 VTEKSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQ 2653
            + E +       H E  EA          E  ++   +TK+          E E   ++ 
Sbjct: 1619 IDEDA-GRRHSWHDEDDEAFD--------ESPELKYRETKS---------QESEELVVTG 1660

Query: 2654 EGNL----VLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRP 2709
             G L     +E +S     +S E  Q +++ L      ++  E++    ++++ G     
Sbjct: 1661 GGGLRRFKTIELNSTIADKYSAESSQ-KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSS 1719

Query: 2710 LEESKVLVEKTKTFLPVVLSCHDEIENHSLS-QEGNLVLEKSSRDMP---------DHSE 2759
            L  S      T    P  +S  DE  + S S ++G    ++ +R  P         D SE
Sbjct: 1720 LHASSF----TPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSE 1775

Query: 2760 EKEQFKESELWKGGSV--DITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKP 2817
            E+E  +E EL K      +I ++  K      + ++   R     +  +TPP  LSP++ 
Sbjct: 1776 EEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIED 1835

Query: 2818 QTLASGASPEINAVKKKEMPRS----------------ELTPER----HTVHTIQTSKDD 2857
               AS       A + +E+ RS                E++PE+      V+ + T+   
Sbjct: 1836 ---ASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSL 1892

Query: 2858 TSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEP 2917
             S   +QS++  +   +A         L SA+  Y + +  T    A    + ++   E 
Sbjct: 1893 YSPTDEQSIMQKEGSQKA---------LKSAEEMYEEMMHKTHKYKAFPAANERDEVFEK 1943

Query: 2918 EDTY 2921
            E  Y
Sbjct: 1944 EPLY 1947



 Score = 37.0 bits (84), Expect = 0.40
 Identities = 50/218 (22%), Positives = 85/218 (38%), Gaps = 9/218 (4%)

Query: 1566 TASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKK 1625
            + + SP    + +G+   L  LS+++ +    V S AQG  P      A AE    P   
Sbjct: 27   SGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQG-LPKGSVPPAAAE---SPSMH 82

Query: 1626 DKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEEN 1685
             K       P   S    D GR +    +K   +    +E  +  + P+ +  +E K   
Sbjct: 83   RKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRT 142

Query: 1686 --RELCASSTMPA-ISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQ 1742
              +E   SS MP  +SE+++L    S   +  PF     S  S+E      +    E+ +
Sbjct: 143  DLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGK 202

Query: 1743 PFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKA 1780
            P       L ++   P   ++G  ++  PL   G  K+
Sbjct: 203  PEGIIKPPLQQQPPKPIPKQQGPGRD--PLQQDGTPKS 238



 Score = 34.3 bits (77), Expect = 2.6
 Identities = 180/880 (20%), Positives = 285/880 (32%), Gaps = 136/880 (15%)

Query: 569  ASSPEHVA-----------LSEEEREEIASVSTGSAFVSEYSVP-----QDLNHELQE-- 610
            A SP H A           LSEEER +IA+V + +  + + SVP         H  QE  
Sbjct: 29   AGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELD 88

Query: 611  ------QEGEPVPPSNVEAIAEHAVLSEEENEEF--EAYSPAAAPTSES-SLSPSTTEKT 661
                  Q G P  P      A+  +      + F  E   P  +P++ S   S S T+  
Sbjct: 89   SSHPPKQSGRPPDPGRP---AQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLK 145

Query: 662  SENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSPL 721
             E++S +      E   LS   +  +     D  S SE S      K+ + +    K   
Sbjct: 146  EEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEG 205

Query: 722  ILKGVSEYMIPSEEKEDTG--------SFTPAVAPASEPSLSPSTTEKTSE-CQSPLPST 772
            I+K   +   P    +  G          TP    + +P    S    T +  Q P  + 
Sbjct: 206  IIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTP 265

Query: 773  ATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTV 832
             T    +P + +   S   T  + ++   +   +    S K  I + +  KP        
Sbjct: 266  QTDHAKLPLQRD--ASRPQTKQADIVRGESVKPSLPSPS-KPPIQQPTPGKPPAQQPGHE 322

Query: 833  LSVDG--KEVIGPSSPDLVVASEHSF------PPHTTEMTSE---CQAPPLSATPSEYVV 881
             S  G  K    PS     +A +         PP TT+  ++      PP   T SE   
Sbjct: 323  KSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP- 381

Query: 882  LSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQED 941
             S E+        P     +    P  A P  Q+           G  SP       +  
Sbjct: 382  -SSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTP 440

Query: 942  IGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPD 1001
            +    P      +      + Q+    +     P     P +    +    ++     P 
Sbjct: 441  VQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP 500

Query: 1002 SASQVSI--PPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFS 1059
            S    S   PP +    + +  +P S        G      A       + A P ++Q +
Sbjct: 501  SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG-----SAKPSAQQPSPAKPSAQQST 555

Query: 1060 SSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSV--SEYLILAQKQKTQA 1117
                Q     PL         PP+   S K      +P T   +  +  L+L   +K   
Sbjct: 556  KPVSQTGSGKPLQ--------PPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANF 607

Query: 1118 YLEPESEDLIPS--------HLTSEVE------KGEREASSSVAAIPAALPAQSSIVKEE 1163
                E +  + S        HLT   E      + +R     +A +P+     S   K +
Sbjct: 608  NTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS-----SPQPKLK 662

Query: 1164 TKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPD-SQEATAHVSQ 1222
            T P +  S +  S P      +P      K A  +  LSK  + +  P   ++ T H S 
Sbjct: 663  TAPVTTTSAVSKSSP------QPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716

Query: 1223 DQKME-------------PQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTS----- 1264
              K +             P+ P+VP  + K  V  D   +PK  VKP   L  +S     
Sbjct: 717  SAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM-VKPTTDLVSSSSATTK 775

Query: 1265 -ELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMK-HDSKITTTP-----IVLH 1317
             ++   K+     E   P  PLK  S    ++      ++   DSK    P     I+ H
Sbjct: 776  PDIPSSKVQSQAEEKTTP--PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISH 833

Query: 1318 SASSGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTAS 1357
               S   K  +   P          ++K+ EP  + T  S
Sbjct: 834  PGPSSESKGQKQVDP----------VQKKEEPKKAQTKMS 863


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 287/1441 (19%), Positives = 531/1441 (36%), Gaps = 193/1441 (13%)

Query: 743  TPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSE-----------GEDLGSERF 791
            T  V   S  S S    ++TS  +   P    S+   P +           G      + 
Sbjct: 663  TAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQ 722

Query: 792  TPDSKLISKYAAPLNAT--QESQKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLV 849
             P++  +SK A P   +   E  K  + +    +PK +   T L         P  P   
Sbjct: 723  PPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSK 782

Query: 850  V---ASEHSFPPHTTEMTSECQAPP-----LSATPSEYVVLSDEEAVELERYTPSSTSAS 901
            V   A E + PP  T+     Q+ P     +S   S+ +     ++  +    PSS S  
Sbjct: 783  VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKG 842

Query: 902  EFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPYA 961
            +  V P    E  E +     ++ K  + PM           P +  +    + S  P  
Sbjct: 843  QKQVDPVQKKE--EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKP-- 898

Query: 962  TQEAEKREFEC------DSPICLTSPSEHTILSDEDTEEAELFS-------------PDS 1002
              + + R F        D+P    +  + T+        A +FS             P S
Sbjct: 899  --QEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHS 956

Query: 1003 ASQVSIPPFRI---SETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFS 1059
             S    P  +    S+   ++  P S   A  A   S   + + +   +    P +EQ  
Sbjct: 957  QSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP 1016

Query: 1060 SSQKQKAETFPLMSPLEDL-SLPPSTDKS---EKAEIKPEIPTTSTSVSEYLILAQKQKT 1115
            + ++ + E  P   P++D  SL     K+    K E  P+  +T       L +  K   
Sbjct: 1017 TVKRTETEKKP--PPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPP 1074

Query: 1116 QAYLEPESEDLIPS--------HLTSEVE------KGEREASSSVAAIPAALPAQS---- 1157
                  E ++ + +        HLT   E      + +R  S  +  I    PA S    
Sbjct: 1075 NFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKA 1134

Query: 1158 SIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEAT 1217
            S +   T+ +S  + +P  V  +KK+++      +K   E++ L KV++       ++  
Sbjct: 1135 SPMPVPTESSSQKTAVPPQVKLVKKQEQE-----VKTEAEKVILEKVKE---TLSMEKIP 1186

Query: 1218 AHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPE 1277
              V+ DQK E       ES+++      + ++     + KL+       E++  S+ +  
Sbjct: 1187 PMVTTDQKQE-------ESKLEKDKASALQEKKPLPEEKKLIPE-----EEKIRSEEKKP 1234

Query: 1278 VIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFS 1337
            +++   P  E     PEA ++   E KHD        +L S     E+++E G  A    
Sbjct: 1235 LLEEKKPTPEDKKLLPEAKTSAPEEQKHD--------LLKSQVQIAEEKLE-GRVAPKTV 1285

Query: 1338 ALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEE----IPTDSSLITPVDRPVLTKVGK 1393
               ++ + ++E   S T  S+ K D   T+ +KE+           + P       +  K
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDK 1345

Query: 1394 GELGSGLPPLVTSADEHSVLAEEDKVAIKGASP--IETSSKHLAWSEAEKEIKFDSLPSV 1451
             +  S   P        +  + +   +  G  P  I T  K +      K +K DS    
Sbjct: 1346 SDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDIL-----KGLKKDSFSQE 1400

Query: 1452 SSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSS 1511
            SS +  S L+++E+      L +++  +S  +D+  E + +  +      V   +     
Sbjct: 1401 SSPSSPSDLAKLESTV----LSILEAQASTLADEKSEKKTQPHE------VSPEQPKDQE 1450

Query: 1512 QKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGK--DEETASS 1569
            + +SL  T E+   E E+  S   + ++K+T    SQ   P+SK    K +  D+ T   
Sbjct: 1451 KTQSLSETLEITISEEEIKES---QEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRR 1507

Query: 1570 SPE---LENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKD 1626
             P     E+  S  +P        + K    V S++  ++  E    +        E++D
Sbjct: 1508 EPYDSVEESSESENSPV------PQRKRRTSVGSSSSDEYKQEDSQGS-------GEEED 1554

Query: 1627 KPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENR 1686
               + +   +A  + S   G +       Q K   + TE    E+   + +   GK  +R
Sbjct: 1555 FIRKQIIEMSADEDAS---GSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGK--HR 1609

Query: 1687 ELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPAS---VAEGGNPEEFQP 1743
             L   S+     +         +++E    SP++   E+K   +    V  GG    F+ 
Sbjct: 1610 RLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKT 1669

Query: 1744 FTFSLKGLSEEVSHPADFKKGG-----NQEIGPLPPTGNLKAQVMGDILDKLSEETGHPN 1798
               +   ++++ S  +  KK         E+     T + + +  G+    L   +  P 
Sbjct: 1670 IELN-STIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPG 1728

Query: 1799 SSQV-LQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSED----KQDLGIKQ 1853
            +S   + S+ E S  +PS    E K+  KA H      LP +  SSE+    +++  +K+
Sbjct: 1729 TSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKE 1788

Query: 1854 FSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGS 1913
                RE +  +Q KS       D  E + +     PK     L   E+ +   E R A  
Sbjct: 1789 QEKQRE-IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAE 1847

Query: 1914 V-QLDSSSSNELRP---GQLKAAVSSKDHTCEVRK--------QVLPHSAEESHLSSQEA 1961
            + +L  SS +E  P      +    S +   EV+K         +   + E+S +  + +
Sbjct: 1848 MEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGS 1907

Query: 1962 VSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLV----LAGNVERNIAEGKEIHSLMES- 2016
              AL ++    E +  K++  +    A E   +     L G +   + E     SL+E  
Sbjct: 1908 QKALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGM---LIEDYIYESLVEDT 1964

Query: 2017 -----ESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKP---VSGLSVEQVKSETISSS 2068
                 +  LL +   E  +  ++  ++KI+L  E+ ++ P   ++ L  E  + E++ S 
Sbjct: 1965 YNGSVDGSLLTRQEEENGFMQQKGREQKIRL-SEQIYEDPMQKITDLQKEFYELESLHSV 2023

Query: 2069 V 2069
            V
Sbjct: 2024 V 2024



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 380/1955 (19%), Positives = 693/1955 (35%), Gaps = 278/1955 (14%)

Query: 439  ASPGLAAS-TQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSVKGEKEENMLEPSISLSE 497
            A PGL+ S T D    +Q+ P  +       +S K + +   +K E + +M+   +S   
Sbjct: 106  AQPGLSKSRTTDTFRSEQKLPGRSP----STISLKESKSRTDLKEEHKSSMMPGFLSEVN 161

Query: 498  PLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSEKPF---PPHMSPE 554
             L        +      I+ +   ++    ++++V+ +  +   + + P    PP   P+
Sbjct: 162  ALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPK 221

Query: 555  VEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQE-- 612
             +    +   PL    +P+ ++  + E+ +     TG         PQ  + +L  Q   
Sbjct: 222  QQGPGRD---PLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDA 278

Query: 613  ------------GEPVPPS-------NVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSL 653
                        GE V PS        ++        +++   E     PA  P   S L
Sbjct: 279  SRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGL 338

Query: 654  SPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVP-SLATKESLK 712
            +    ++    + P+    T +        A      T     +SE   P +LA    + 
Sbjct: 339  TKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG 398

Query: 713  KTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPST 772
            KT  ++         +   P    +  G  +PA AP   P+ +P         Q P P  
Sbjct: 399  KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPG--PTKTP--------VQQPGPGK 448

Query: 773  ATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTV 832
              ++   P +     +    P S+L    A P        K    +    KP   S+   
Sbjct: 449  IPAQQAGPGKTSAQQTGPTKPPSQLPGP-AKPPPQQPGPAKPPPQQPGSAKPP--SQQPG 505

Query: 833  LSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELER 892
             +    +  GP+ P           P     T      P SA PS       + + +   
Sbjct: 506  STKPPPQQPGPAKPS----------PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQST 555

Query: 893  YTPSSTSASEFSVPPYATPEAQE--EEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSA 950
               S T + +   PP  +P A++   + + +++     ++ + L   ++ +    +    
Sbjct: 556  KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQT 615

Query: 951  FVSE---FSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVS 1007
             V     F+  P+ T+  E         +CL    +  +  D     A + S       +
Sbjct: 616  TVCSLCGFNPNPHLTEVKEW--------LCLNCQMKRALGGDL----APVPSSPQPKLKT 663

Query: 1008 IPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQK-- 1065
             P    S   K+  +P        A+     S+A E           +   S S K K  
Sbjct: 664  APVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQP 723

Query: 1066 --AETFPLMSPLEDLSLPPSTDKSEKAEIKPEIP----TTSTSVSEYLILAQKQKTQAYL 1119
              A++    +P ++ S+P   DK+  A+ KP+ P     T+  VS      +     + +
Sbjct: 724  PEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKV 783

Query: 1120 EPESEDLIPSHLTSEVEK--------GEREASSSVAAIPAALPAQSSIVKEETKPASPHS 1171
            + ++E+     L ++  K        GE+ +     AIP   PA  S +     P+S  S
Sbjct: 784  QSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPR--PASDSKIISHPGPSS-ES 840

Query: 1172 VLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPP 1231
                 V  ++K++EP  A T  +         + K    P     TA   Q      Q P
Sbjct: 841  KGQKQVDPVQKKEEPKKAQTKMSPKPD--AKPMPKGSPTPPGPRPTA--GQTVPTPQQSP 896

Query: 1232 NVPESEMKYSV-LPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETS- 1289
               E   ++S+ L  + D PK   +P        E    KL      +    S L  T+ 
Sbjct: 897  KPQEQSRRFSLNLGSITDAPKS--QP----TTPQETVTGKLFGFGASIFSQASNLISTAG 950

Query: 1290 LSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKEIEP 1349
              GP + S     MK     +  P      S G  K     PPA    A S  +KKE + 
Sbjct: 951  QPGPHSQSGPGAPMKQAPAPSQPP-----TSQGPPKSTGQAPPA---PAKSIPVKKETKA 1002

Query: 1350 SSSTTTASVTKLDSNLTRAVKEEIP---TDSSLIT--PVDRPVLTKVGKG---------- 1394
             ++       +    + R   E+ P    DS  +T  P    + TK+ K           
Sbjct: 1003 PAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062

Query: 1395 ----ELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPS 1450
                 +GS  PP   +  E     +     + G +P    + HL   +    +   +  +
Sbjct: 1063 KTELNIGSKDPPNFNTCTE----CKNQVCNLCGFNP----TPHLTEIQEWLCLNCQTQRA 1114

Query: 1451 VS-SIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLV 1509
            +S  + +   +    +    + +PV   SSSQ +    + ++  KQ+    T  ++E+++
Sbjct: 1115 ISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKT--EAEKVI 1172

Query: 1510 SSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGK---DEET 1566
              + K  +S  ++       P  +  + K++E++L   +  +   K  +P+ K    EE 
Sbjct: 1173 LEKVKETLSMEKI-------PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEE 1225

Query: 1567 ASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLE----P 1622
               S E + L     PT     D K  P  + S+  +      K  V +AE  LE    P
Sbjct: 1226 KIRSEEKKPLLEEKKPT---PEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAP 1282

Query: 1623 EKKDKPHQPLE----LPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRS 1678
            +   +  QP      LP+   +       ++     +Q + P T   D V E G    + 
Sbjct: 1283 KTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQV-EPG----KE 1337

Query: 1679 REGKEENRELCASSTMP------------------AISELSSL-----------LREESQ 1709
            +  KE+++   +SS  P                  ++ E+ SL           L+++S 
Sbjct: 1338 KTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSF 1397

Query: 1710 NEEIKPFSPK-IISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQE 1768
            ++E  P SP  +  LES       A+                L++E S     KK    E
Sbjct: 1398 SQESSPSSPSDLAKLESTVLSILEAQAST-------------LADEKSE----KKTQPHE 1440

Query: 1769 IGPLPPTGNLKAQVMGDILD-KLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKA 1827
            + P  P    K Q + + L+  +SEE       ++ +S  E       D   +Q      
Sbjct: 1441 VSPEQPKDQEKTQSLSETLEITISEE-------EIKESQEERKDTFKKD--SQQDIPSSK 1491

Query: 1828 LHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFI 1887
             H +++  + D++T  E    +   + S   EN P+ Q K   +   +   E K E+   
Sbjct: 1492 DHKEKSEFVDDITTRREPYDSV---EESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQG 1548

Query: 1888 SPKDENW-------MLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQL--KAAVSSKDH 1938
            S ++E++       M    +   S+ ++ I   ++  SSS+   +  +   K  +++  H
Sbjct: 1549 SGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKH 1608

Query: 1939 TCEVRKQ--VLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVL 1996
                RK    +   A   H    E   A D  S   +   +KS  SEE+ +      L  
Sbjct: 1609 RRLTRKSSTSIDEDAGRRHSWHDEDDEAFD-ESPELKYRETKSQESEEL-VVTGGGGLRR 1666

Query: 1997 AGNVERN--IAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSG 2054
               +E N  IA+     S  +  SL  ++   EL   S  DS      P +R   +  S 
Sbjct: 1667 FKTIELNSTIADKYSAESSQKKTSLYFDE-EPELEMESLTDS------PEDRSRGEGSSS 1719

Query: 2055 LSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVID 2114
            L        T  +SV +    ++        E +  R     P    L          I+
Sbjct: 1720 LHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLL--------PTIE 1771

Query: 2115 DADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKG 2174
            D+ E ++   E ++  +++    I  ++ +S            + K  K +L  ++ ++ 
Sbjct: 1772 DSSEEEELREEEELLKEQEKQREIEQQQRKSSSK---------KSKKDKDELRAQRRRER 1822

Query: 2175 ISSFKSWMSSLFFGSSTPD-NKVAEQEDLE----TQPSPSVEKAVTVIDPEGTIPTNFNV 2229
              +  S +S +   S T +  + AE E+L     ++ SPS+E      DPEG   +   +
Sbjct: 1823 PKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIES-----DPEGFEISPEKI 1877

Query: 2230 AEKPADHSL-SEVKLKTADEPRGTLVKSGDGQNVK 2263
             E    + L + V L +  + +  + K G  + +K
Sbjct: 1878 IEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALK 1912



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 281/1444 (19%), Positives = 520/1444 (36%), Gaps = 240/1444 (16%)

Query: 1567 ASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAE-------LS 1619
            +S  P+L+      AP     +  K+ P  + +S  +   P  KQD++ A        L 
Sbjct: 655  SSPQPKLKT-----APVTTTSAVSKSSPQPQQTSPKKDAAP--KQDLSKAPEPKKPPPLV 707

Query: 1620 LEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSR 1679
             +P     P    + P      S     +  S+ ++Q K+P+ + +     K P  ++  
Sbjct: 708  KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKP----KQPKMVKP- 762

Query: 1680 EGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPE 1739
                   +L +SS+     ++ S  + +SQ EE K   P  +  +S +P  S    G  E
Sbjct: 763  -----TTDLVSSSSATTKPDIPSS-KVQSQAEE-KTTPP--LKTDSAKPSQSFPPTG--E 811

Query: 1740 EFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNS 1799
            +  PF       S+ +  PA   K     I    P+   K Q   D + K  E    P  
Sbjct: 812  KVSPFD------SKAIPRPASDSK----IISHPGPSSESKGQKQVDPVQKKEE----PKK 857

Query: 1800 SQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRE 1859
            +Q   S    +K  P            A    QTV  P  S   +++     ++FSL   
Sbjct: 858  AQTKMSPKPDAKPMPKGSPTPPGPRPTA---GQTVPTPQQSPKPQEQS----RRFSLNLG 910

Query: 1860 NLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSS 1919
            ++  +  KS  TT P +    K+  F  S   +   L         H Q   G+    + 
Sbjct: 911  SIT-DAPKSQPTT-PQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAP 968

Query: 1920 S-----SNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEA--VSALDTSSGNT 1972
            +     +++  P     A  +   +  V+K+    +AE+    +++A  V   +T     
Sbjct: 969  APSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPP 1028

Query: 1973 ETLSSKSYSSEEVKL--------AEEPKSLVLAGNVERNIA--EGKEIHSLMESESLLLE 2022
                SKS ++E  K         + +P+S       E NI   +    ++  E ++ +  
Sbjct: 1029 PIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCN 1088

Query: 2023 KANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPA 2082
                  + P   + QE + L  +   Q+ +SG   +  K     S  K +  P   V   
Sbjct: 1089 LCGFNPT-PHLTEIQEWLCLNCQT--QRAISGQLGDIRKMPPAPSGPKASPMP---VPTE 1142

Query: 2083 LGNEKEAHRSTPPF-------PEEKPLEESKMVQSKVIDDADEGKKP------SPEVKIP 2129
              ++K A    PP         +E   E  K++  KV +     K P        + +  
Sbjct: 1143 SSSQKTA---VPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESK 1199

Query: 2130 TQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGS 2189
             ++   S++  ++P   E   + +    + +  KP L E+K                   
Sbjct: 1200 LEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKK------------------- 1240

Query: 2190 STPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEP 2249
             TP++K    E   + P                + +   +AE+  +  ++   ++   +P
Sbjct: 1241 PTPEDKKLLPEAKTSAPEEQ---------KHDLLKSQVQIAEEKLEGRVAPKTVQEGKQP 1291

Query: 2250 RGTL--VKSGDGQNV-KEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSV 2306
            +  +  + SG  Q++ KE       +++  QP   ++  + + GK++   + ++ + +S 
Sbjct: 1292 QTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSS 1351

Query: 2307 VTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEP 2366
                  + L    YS  G    + E  +++P   TD K + K           S  +E  
Sbjct: 1352 QQPKSPQGLSDTGYSSDGISSSLGEIPSLIP---TDEKDILK------GLKKDSFSQESS 1402

Query: 2367 RSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESIILPVEESKGSLIDFSE 2426
             S     + L   V+  +  Q  + +   + K        PE    P ++ K        
Sbjct: 1403 PSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQ---PKDQEK-------- 1451

Query: 2427 DRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRS-YTLAEKKVLAEKQNSVAPLEL 2485
                + +     + ISEEE K    S  E+KD  +  S   +   K   EK   V  +  
Sbjct: 1452 ---TQSLSETLEITISEEEIK---ESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITT 1505

Query: 2486 R--------DSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNE---RPKIIVGSE 2534
            R        +S+E   + +    R T +  S +D   Q   Q     E   R +II  S 
Sbjct: 1506 RREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSA 1565

Query: 2535 KEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGH-SLGETQSFSLVKATS 2593
             E     E+  ++ ++ K+         +  ES  +E     G  + G+ +  +   +TS
Sbjct: 1566 DEDASGSEDDEFIRNQLKEIS-------SSTESQKKEETKGKGKITAGKHRRLTRKSSTS 1618

Query: 2594 VTEKSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQ 2653
            + E +       H E  EA          E  ++   +TK+          E E   ++ 
Sbjct: 1619 IDEDA-GRRHSWHDEDDEAFD--------ESPELKYRETKS---------QESEELVVTG 1660

Query: 2654 EGNL----VLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRP 2709
             G L     +E +S     +S E  Q +++ L      ++  E++    ++++ G     
Sbjct: 1661 GGGLRRFKTIELNSTIADKYSAESSQ-KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSS 1719

Query: 2710 LEESKVLVEKTKTFLPVVLSCHDEIENHSLS-QEGNLVLEKSSRDMP---------DHSE 2759
            L  S      T    P  +S  DE  + S S ++G    ++ +R  P         D SE
Sbjct: 1720 LHASSF----TPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSE 1775

Query: 2760 EKEQFKESELWKGGSV--DITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKP 2817
            E+E  +E EL K      +I ++  K      + ++   R     +  +TPP  LSP++ 
Sbjct: 1776 EEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIED 1835

Query: 2818 QTLASGASPEINAVKKKEMPRS----------------ELTPER----HTVHTIQTSKDD 2857
               AS       A + +E+ RS                E++PE+      V+ + T+   
Sbjct: 1836 ---ASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSL 1892

Query: 2858 TSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEP 2917
             S   +QS++  +   +A         L SA+  Y + +  T    A    + ++   E 
Sbjct: 1893 YSPTDEQSIMQKEGSQKA---------LKSAEEMYEEMMHKTHKYKAFPAANERDEVFEK 1943

Query: 2918 EDTY 2921
            E  Y
Sbjct: 1944 EPLY 1947



 Score = 37.0 bits (84), Expect = 0.40
 Identities = 50/218 (22%), Positives = 85/218 (38%), Gaps = 9/218 (4%)

Query: 1566 TASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKK 1625
            + + SP    + +G+   L  LS+++ +    V S AQG  P      A AE    P   
Sbjct: 27   SGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQG-LPKGSVPPAAAE---SPSMH 82

Query: 1626 DKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEEN 1685
             K       P   S    D GR +    +K   +    +E  +  + P+ +  +E K   
Sbjct: 83   RKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRT 142

Query: 1686 --RELCASSTMPA-ISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQ 1742
              +E   SS MP  +SE+++L    S   +  PF     S  S+E      +    E+ +
Sbjct: 143  DLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGK 202

Query: 1743 PFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKA 1780
            P       L ++   P   ++G  ++  PL   G  K+
Sbjct: 203  PEGIIKPPLQQQPPKPIPKQQGPGRD--PLQQDGTPKS 238



 Score = 34.3 bits (77), Expect = 2.6
 Identities = 180/880 (20%), Positives = 285/880 (32%), Gaps = 136/880 (15%)

Query: 569  ASSPEHVA-----------LSEEEREEIASVSTGSAFVSEYSVP-----QDLNHELQE-- 610
            A SP H A           LSEEER +IA+V + +  + + SVP         H  QE  
Sbjct: 29   AGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELD 88

Query: 611  ------QEGEPVPPSNVEAIAEHAVLSEEENEEF--EAYSPAAAPTSES-SLSPSTTEKT 661
                  Q G P  P      A+  +      + F  E   P  +P++ S   S S T+  
Sbjct: 89   SSHPPKQSGRPPDPGRP---AQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLK 145

Query: 662  SENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSPL 721
             E++S +      E   LS   +  +     D  S SE S      K+ + +    K   
Sbjct: 146  EEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEG 205

Query: 722  ILKGVSEYMIPSEEKEDTG--------SFTPAVAPASEPSLSPSTTEKTSE-CQSPLPST 772
            I+K   +   P    +  G          TP    + +P    S    T +  Q P  + 
Sbjct: 206  IIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTP 265

Query: 773  ATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTV 832
             T    +P + +   S   T  + ++   +   +    S K  I + +  KP        
Sbjct: 266  QTDHAKLPLQRD--ASRPQTKQADIVRGESVKPSLPSPS-KPPIQQPTPGKPPAQQPGHE 322

Query: 833  LSVDG--KEVIGPSSPDLVVASEHSF------PPHTTEMTSE---CQAPPLSATPSEYVV 881
             S  G  K    PS     +A +         PP TT+  ++      PP   T SE   
Sbjct: 323  KSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP- 381

Query: 882  LSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQED 941
             S E+        P     +    P  A P  Q+           G  SP       +  
Sbjct: 382  -SSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTP 440

Query: 942  IGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPD 1001
            +    P      +      + Q+    +     P     P +    +    ++     P 
Sbjct: 441  VQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP 500

Query: 1002 SASQVSI--PPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFS 1059
            S    S   PP +    + +  +P S        G      A       + A P ++Q +
Sbjct: 501  SQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG-----SAKPSAQQPSPAKPSAQQST 555

Query: 1060 SSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSV--SEYLILAQKQKTQA 1117
                Q     PL         PP+   S K      +P T   +  +  L+L   +K   
Sbjct: 556  KPVSQTGSGKPLQ--------PPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANF 607

Query: 1118 YLEPESEDLIPS--------HLTSEVE------KGEREASSSVAAIPAALPAQSSIVKEE 1163
                E +  + S        HLT   E      + +R     +A +P+     S   K +
Sbjct: 608  NTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS-----SPQPKLK 662

Query: 1164 TKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPD-SQEATAHVSQ 1222
            T P +  S +  S P      +P      K A  +  LSK  + +  P   ++ T H S 
Sbjct: 663  TAPVTTTSAVSKSSP------QPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716

Query: 1223 DQKME-------------PQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTS----- 1264
              K +             P+ P+VP  + K  V  D   +PK  VKP   L  +S     
Sbjct: 717  SAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM-VKPTTDLVSSSSATTK 775

Query: 1265 -ELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMK-HDSKITTTP-----IVLH 1317
             ++   K+     E   P  PLK  S    ++      ++   DSK    P     I+ H
Sbjct: 776  PDIPSSKVQSQAEEKTTP--PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISH 833

Query: 1318 SASSGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTAS 1357
               S   K  +   P          ++K+ EP  + T  S
Sbjct: 834  PGPSSESKGQKQVDP----------VQKKEEPKKAQTKMS 863


>gi|46409324 SPRY domain containing 4 [Homo sapiens]
          Length = 207

 Score = 76.6 bits (187), Expect = 5e-13
 Identities = 51/196 (26%), Positives = 88/196 (44%), Gaps = 13/196 (6%)

Query: 3882 FGTSEQSEAALISTRGTRFLLLRETAHPALHISSSGTVISFG-----------ERRRLTE 3930
            +G      A+  + RG  F L  +TAH +L +    T + +G              R  E
Sbjct: 14   WGAKRLGVASTEAQRGVSFKLEEKTAHSSLALFRDDTGVKYGLVGLEPTKVALNVERFRE 73

Query: 3931 IPSVLGEELPSCGQHYWETTVTDCPAYRLGICSSSAVQAGALGQGETSWYMHCSEPQRYT 3990
               VL +   + G+HYWE TV     +R+G+      +   +G  + SW    ++ + YT
Sbjct: 74   WAVVLADTAVTSGRHYWEVTVKRSQQFRIGVADVDMSRDSCIGVDDRSWVFTYAQRKWYT 133

Query: 3991 FFYSGIVSDVHVTERPARVGILLDYNNQRLIFINAESEQLLFIIRHRFNEGVHPAFALEK 4050
               +   + V    +P +VG+LL+Y  Q+L  ++     ++  ++  F   V PAFAL  
Sbjct: 134  ML-ANEKAPVEGIGQPEKVGLLLEYEAQKLSLVDVSQVSVVHTLQTDFRGPVVPAFAL-W 191

Query: 4051 PGKCTLHLGIEPPDSV 4066
             G+   H G+E P+ +
Sbjct: 192  DGELLTHSGLEVPEGL 207


>gi|78482626 ring finger protein 30 isoform 2 [Homo sapiens]
          Length = 358

 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 48/218 (22%), Positives = 107/218 (49%), Gaps = 6/218 (2%)

Query: 3490 QLSSEVVTEKAQKEL-----KKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISA 3544
            Q SS  +  KA++ L     ++ +I+ YC +C+ P  +  KVFG HKD EV+ L T    
Sbjct: 110  QESSRPLHSKAEQHLMCEEHEEEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKR 169

Query: 3545 VKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYD 3604
             K +L++ +  L   + R++A ++++E    TIE+N  + ++ L ++ E +   +  +  
Sbjct: 170  QKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFESLCAVLEERKG 229

Query: 3605 EKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINER 3664
            E  Q+    +++K++ +   +  +   ++ +   +E+ ++  EE   A++L   +E+  +
Sbjct: 230  ELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINK 289

Query: 3665 LLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQV 3702
             + AM       +    +   E +        +ML+ +
Sbjct: 290  -VGAMSKVELAGRPEPGYESMEQFTVRVEHVAEMLRTI 326


>gi|19924163 muscle specific ring finger protein 1 [Homo sapiens]
          Length = 353

 Score = 72.4 bits (176), Expect = 9e-12
 Identities = 38/167 (22%), Positives = 85/167 (50%)

Query: 3502 KELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSL 3561
            KE +  +I+ YC TC+ P  +  KVFG HK  EV+ L +     K +L   +  L   + 
Sbjct: 123  KEHEDEKINIYCLTCEVPTCSMCKVFGIHKACEVAPLQSVFQGQKTELNNCISMLVAGND 182

Query: 3562 RIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFL 3621
            R++  ++++E      +EN  + ++ L ++ + +   +  +  E  Q   + ++KK+ F+
Sbjct: 183  RVQTIITQLEDSRRVTKENSHQVKEELSQKFDTLYAILDEKKSELLQRITQEQEKKLSFI 242

Query: 3622 HEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSA 3668
               +  + + +D +   +ET ++  +E   A FL + +++ + ++ A
Sbjct: 243  EALIQQYQEQLDKSTKLVETAIQSLDEPGGATFLLTAKQLIKSIVEA 289


>gi|190341104 tripartite motif protein 9 isoform 1 [Homo sapiens]
          Length = 710

 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 75/275 (27%), Positives = 123/275 (44%), Gaps = 28/275 (10%)

Query: 3804 PSTPVIRAEDCTVCWNTATIRWR--PTTPEATETYTLEYCRQHSPEGEGLRSFSGIKGLQ 3861
            P+TP+++ E+C    N+AT+ W+  P +    + Y LE        G+    + G + + 
Sbjct: 441  PATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILEL--DDGNGGQFREVYVGKETMC 498

Query: 3862 LKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTR-FLLLRETAHPALHISSSG--- 3917
                L  N  Y   V+A N  G S  S+  ++ T     F     +AH  + +S+     
Sbjct: 499  TVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIILSNDNLTV 558

Query: 3918 TVISFGERRRLTEIPSVLGEELPSCGQHYWETTV---TDCPAYRLGICSSSAVQAGALGQ 3974
            T  S+ +R        VLG+   S G HYWE TV    + P    G+     ++   LG+
Sbjct: 559  TCSSYDDR-------VVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGK 611

Query: 3975 GETSWYMHCSEPQRYTFFYSGIVSDVHVTE----RPARVGILLDYNNQRLIFINAESEQL 4030
             + +W M+  +  R  F ++   S  + TE    + A +G+LLD N + L F   + +Q 
Sbjct: 612  DDKAWAMYV-DNNRSWFMHNN--SHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQ- 667

Query: 4031 LFIIRHRFNEGV-HPAFALEKPGKCTLHLGIEPPD 4064
               I     EG+  PA +L +  + TLH G+  PD
Sbjct: 668  -GPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPD 701



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 77/329 (23%), Positives = 130/329 (39%), Gaps = 30/329 (9%)

Query: 3490 QLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQL 3549
            +LS   V+     EL+   +  YC  CK P+       G H  HEV  L       K QL
Sbjct: 220  RLSPRKVSTCTDHELENHSM--YCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQL 277

Query: 3550 AEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQS 3609
            ++ L  L +++   + F+ ++ +    I+EN  + E  L  Q + ++    A    KAQ 
Sbjct: 278  SQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALID---ALNRRKAQL 334

Query: 3610 FEEVKKK---KMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLL 3666
               V K+   K++ + +Q+ H    +      +E  +   +E D + FL   + +  R+ 
Sbjct: 335  LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVH 394

Query: 3667 SAMESTASLEKMPAAFSLFEHYDDSSARSD--------QMLKQVAVPQPPRLEPQE---- 3714
               +        P   + F+   D+S            Q+     VP  P L+ +E    
Sbjct: 395  LTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTH 454

Query: 3715 PNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLE 3774
             NSAT     + W       + +   Y +E   DD    +  E Y    KE+ C  + L 
Sbjct: 455  NNSAT-----LSWKQPPLSTVPA-DGYILE--LDDGNGGQFREVY--VGKETMCTVDGLH 504

Query: 3775 PDRCYQVWVMAVNFTGCSLPSERAIFRTA 3803
             +  Y   V A N TG S  S+  + +T+
Sbjct: 505  FNSTYNARVKAFNKTGVSPYSKTLVLQTS 533


>gi|63054855 erythroblast membrane-associated protein precursor [Homo
            sapiens]
          Length = 475

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 53/168 (31%), Positives = 73/168 (43%), Gaps = 13/168 (7%)

Query: 3905 ETAHPALHISSSGTVISFGERR--------RLTEIPSVLGEELPSCGQHYWETTVTDCPA 3956
            +TAHP L +S     +  G+RR        R   + S+LG E  + G HYWE  V D   
Sbjct: 245  DTAHPKLILSEDQRCVRLGDRRQPVPDNPQRFDFVVSILGSEYFTTGCHYWEVYVGDKTK 304

Query: 3957 YRLGICSSSAVQAGALGQGETS--WYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLD 4014
            + LG+CS S  + G +     +  W +  S    Y    S   S   + E P  VGI LD
Sbjct: 305  WILGVCSESVSRKGKVTASPANGHWLLRQSRGNEYEALTSPQTS-FRLKEPPRCVGIFLD 363

Query: 4015 YNNQRLIFINAESEQLLFIIRHRFNEGVHPAF--ALEKPGKCTLHLGI 4060
            Y    + F N  ++  +F   H F+  + P F   L   GK T  L I
Sbjct: 364  YEAGVISFYNVTNKSHIFTFTHNFSGPLRPFFEPCLHDGGKNTAPLVI 411


>gi|19923536 erythroblast membrane-associated protein precursor [Homo
            sapiens]
          Length = 475

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 53/168 (31%), Positives = 73/168 (43%), Gaps = 13/168 (7%)

Query: 3905 ETAHPALHISSSGTVISFGERR--------RLTEIPSVLGEELPSCGQHYWETTVTDCPA 3956
            +TAHP L +S     +  G+RR        R   + S+LG E  + G HYWE  V D   
Sbjct: 245  DTAHPKLILSEDQRCVRLGDRRQPVPDNPQRFDFVVSILGSEYFTTGCHYWEVYVGDKTK 304

Query: 3957 YRLGICSSSAVQAGALGQGETS--WYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLD 4014
            + LG+CS S  + G +     +  W +  S    Y    S   S   + E P  VGI LD
Sbjct: 305  WILGVCSESVSRKGKVTASPANGHWLLRQSRGNEYEALTSPQTS-FRLKEPPRCVGIFLD 363

Query: 4015 YNNQRLIFINAESEQLLFIIRHRFNEGVHPAF--ALEKPGKCTLHLGI 4060
            Y    + F N  ++  +F   H F+  + P F   L   GK T  L I
Sbjct: 364  YEAGVISFYNVTNKSHIFTFTHNFSGPLRPFFEPCLHDGGKNTAPLVI 411


>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
            sapiens]
          Length = 1393

 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 249/1227 (20%), Positives = 427/1227 (34%), Gaps = 188/1227 (15%)

Query: 261  KGKDASISLEPDLDNSGSNTVSKT---RKLVAQSIEDKVKEVFPPWRGALSKGSESLTLM 317
            +GKD  I  +  +D + S T  K    +K +  + + K+           + G  ++T  
Sbjct: 128  QGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKIN------CRKSTTGKSTVTRK 181

Query: 318  FSHEDQKKIYADSPLNATSALEH-TVPSYSSSGRAEQGIQLRHSQSVPQQPEDEAK---- 372
                 +    + S L+ TS   H T  S+ +SG ++     + S S P++    +K    
Sbjct: 182  SDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTK---QKSTSFPEKITAASKTTYK 238

Query: 373  ----PHEVEPPSVTPDTPAT--MFLRTTKEECE----------LASP----GTAASENDS 412
                P E E    +  T A+  +  +TTK   E          LA P    G  A+EN++
Sbjct: 239  TTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTANENNT 298

Query: 413  SVSPSFANEVKKEDVYSAHHSISLEAASP--GLAASTQDGLDPDQEQPDLTSIERAEPVS 470
              SP+   E ++    +A+ + +L  A P      +  +   P    P   + E     +
Sbjct: 299  P-SPAEPTENRER---TANENTTLSPAEPIENRERTANENTAPFPAGPT-ENREMTANEN 353

Query: 471  AKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEE 530
              L P  P+  GE+  N    + S +EP    E    E  T  P   T   E +    ++
Sbjct: 354  TTLFPAEPTEHGERTANE-NTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPFANDK 412

Query: 531  IVELDYPES------PLVSEK--PFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEER 582
                    +      PL +E   P P   +   E    E   P  A  +      + E+ 
Sbjct: 413  TTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKT 472

Query: 583  --EEIASVSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEA 640
                +          +E + P         + G+  P +N +  +  A  +E        
Sbjct: 473  TLSPVEPTENRETTANEKTTPSPAE---PTENGQRTPFANEKTTSSSAEPTEHGER---- 525

Query: 641  YSPAAAPTSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEY 700
                  P +  + +PS  E T   +       TP     S  E +E+G  TP    A+E 
Sbjct: 526  -----TPLANENTTPSPAEPTENRERTANEKTTP-----SPAEPTENGDRTP---LANEK 572

Query: 701  SVPSLATK-ESLKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPA-SEPSLSPST 758
            + PSLA   E+ ++T         K  S    P+E +E T        P+ +EP+ +   
Sbjct: 573  TTPSLAEPTENGQRTPFANE----KTTSSSAEPTEHEERTPLANENTTPSPAEPTENRER 628

Query: 759  TEKTSECQSPLPSTATSEHVVPSE-----GEDLGSERFTPDSKLISKYAAPLNATQESQK 813
            T   +   SP   T   E     +      E   +   T + K  S  A P    Q +  
Sbjct: 629  TANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTP- 687

Query: 814  KIINE---ASQFKPKGISEHTVLSVDGKEVIGPSSPDLV---VASEHS--FPPHTTEMTS 865
               NE   +S  +P    E T L+ +    + P+ P       A+E +  FP   TE   
Sbjct: 688  -FANEKTTSSSAEPTEHGERTPLANENT-TLSPAEPTENRERTANEKTTPFPAEPTENRE 745

Query: 866  ECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSASE------FSVPPYATPEAQEEEIV 919
                   + +P++     D   +  E+ TPS    +E      F+     +  A+  E  
Sbjct: 746  RTANENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHA 805

Query: 920  HRS--LNLKGASSPMNLSEEDQEDIG------PFSP--DSAFVSEFSFPPYATQEAEKRE 969
             R+   N    SSP   +E  +          P  P  +    +     P+  +  E RE
Sbjct: 806  ERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENRE 865

Query: 970  FECDSPICLT--SPSEHTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLL 1027
            +  +    L+   P+EH  ++    E+  L   +        PF   +T  +  EP    
Sbjct: 866  WTANENTTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHG 925

Query: 1028 TAVS-ASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDK 1086
                 A+  +  S A+  + G   A   +    +   +  ET      + + + P S + 
Sbjct: 926  ERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGET-----TVNEDTTPSSAEP 980

Query: 1087 SEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSV 1146
            +E  E  P     +T+       +  + T+      +E   PS      E GER  S++ 
Sbjct: 981  TENGERTPLANENTTT-------SPTESTEHGERTANEKTTPSP-AEPTEHGERTPSANE 1032

Query: 1147 AAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAA-----LTLKAADEQMAL 1201
              IP+  PA+ +   EE  P++  +  P  V   +  ++ T A     L+ +   E  A 
Sbjct: 1033 KTIPS--PAKPT-EHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEHGAK 1089

Query: 1202 SKVRKEEIVPDSQEATAH----------------VSQDQKMEPQPPNV----PESEMKYS 1241
            +    E+I P   + T H                 S + +      NV    P   +K++
Sbjct: 1090 TTSANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRATSANVITPAPAEPIKHA 1149

Query: 1242 VLPDMVDEPKKGVKPKLVLN---VTSELEQRKLS----------------KNEPEVIKPY 1282
                +  E    V  K   +    TS  E+   +                KN P   KP 
Sbjct: 1150 KRTTLAHEKMTQVTEKSTEHPEKTTSTTEKTTRTPEKPTLYSEKTICTKGKNTPVPEKPT 1209

Query: 1283 SPLKETSLS------------GPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHG 1330
              L  T+L+             PE  +AV   +K   K+T    +  ++S   + +V H 
Sbjct: 1210 ENLGNTTLTTETIKAPVKSTENPEKTAAVTKTIKPSVKVTGDKSLTTTSSHLNKTEVTHQ 1269

Query: 1331 PPALAFSALSEEIKKEIEPSSSTTTAS 1357
             P  +F+ ++   K     S +T   S
Sbjct: 1270 VPTGSFTLITSRTKLSSITSEATGNES 1296



 Score = 47.0 bits (110), Expect = 4e-04
 Identities = 248/1268 (19%), Positives = 438/1268 (34%), Gaps = 182/1268 (14%)

Query: 1344 KKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPL 1403
            ++ ++P+ STTT   +    ++T A K +I    S  T     V  K  K   G  L   
Sbjct: 137  QRSVDPADSTTTHKESAGKKHITPAPKSKINCRKS--TTGKSTVTRKSDK--TGRPLEKS 192

Query: 1404 VTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEV 1463
            +++ D+ S  + +   +   +   +T  K  ++ E                         
Sbjct: 193  MSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPE------------------------- 227

Query: 1464 EAKEVKAGLPVIKTSSS-QHSDKSEEARVEDKQDLLFSTVCDSERLVSSQKKSLMSTSEV 1522
              K   A     KT+ + + S+K+E++R     D L +    + +   S  +   S +E 
Sbjct: 228  --KITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEP 285

Query: 1523 LEP------EHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSSPELENL 1576
             E       E+  P S     + +E     +  +SPA     P    E TA+     EN 
Sbjct: 286  TEHGGRTANENNTP-SPAEPTENRERTANENTTLSPAE----PIENRERTAN-----ENT 335

Query: 1577 ASGLA-PTLLL-LSDDKNKPAVEVSSTAQGD-------FPSEKQDVALAELSLEPEKKDK 1627
            A   A PT    ++ ++N        T  G+        PS  +     E +        
Sbjct: 336  APFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPS 395

Query: 1628 PHQPLELPNAGSEFSSDLGRQSGSIGTKQA-KSPITETEDSVLEKGPAELRSREGKE--- 1683
            P +P E     + F++D    S +  T+   ++P+     +     P E R R   E   
Sbjct: 396  PAEPTE-HGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTT 454

Query: 1684 -------ENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGG 1736
                   ENRE  A+          +  RE + NE+  P             PA   E G
Sbjct: 455  PSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTP------------SPAEPTENG 502

Query: 1737 NPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLP--PTGNLKAQVMGDILDKLSEET 1794
                F          S E +   +     N+   P P  PT N +           +E T
Sbjct: 503  QRTPFA--NEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPT 560

Query: 1795 GHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQF 1854
             + + + +    T PS   P++            +  +T    + +TSS  +     ++ 
Sbjct: 561  ENGDRTPLANEKTTPSLAEPTE------------NGQRTPFANEKTTSSSAEPTEHEERT 608

Query: 1855 SLMRENL---PLEQSKSFM-----TTKPADVKETKMEEFFISPKDENWMLGKPENVASQH 1906
             L  EN    P E +++        T P+    T+  E   + K   +     EN     
Sbjct: 609  PLANENTTPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTA 668

Query: 1907 EQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALD 1966
             ++   S   + + + +  P   +   SS     E  ++  P + E + LS  E     +
Sbjct: 669  NEKTTSS-PAEPTENGQRTPFANEKTTSSSAEPTEHGERT-PLANENTTLSPAEPTENRE 726

Query: 1967 TSSGNTETLSSKSYSSEEVKLAEE---PKSLVLAGNVERN-IAEGKEIHSLME--SESLL 2020
             ++    T      +    + A E   P       N +R  +A  K   SL E       
Sbjct: 727  RTANEKTTPFPAEPTENRERTANENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKR 786

Query: 2021 LEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVE 2080
               AN + +  S E ++   + P      +  +    E  ++   +++ KT  FPAE   
Sbjct: 787  TPFANEKTTSSSAEPTEHAERTP---LANENTTSSPAEPTENRERTANEKTTQFPAE--- 840

Query: 2081 PALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHA 2140
            P    E  A+  T PFP E P E  +         A+E    SP    PT+ + ++ + A
Sbjct: 841  PTENRESTANEKTTPFPAE-PTENREWT-------ANENTTLSPAE--PTEHEEMTPL-A 889

Query: 2141 REPQSPESPEVTQN----PPTQPKVAKPDL-PEEKGKKGISSFKSWMSSLFFGSSTPDNK 2195
             E  +    E T+N    P T  K       P E G++  +   + +++      T   +
Sbjct: 890  NEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHGER--TPLANEITTPSRAEPTEHGE 947

Query: 2196 VAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVK 2255
                E     P+   E   T ++ E T P++    E      L+     T+         
Sbjct: 948  RIANEKATPSPAKPTEHGETTVN-EDTTPSSAEPTENGERTPLANENTTTSPTE-----S 1001

Query: 2256 SGDGQNVKEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEM--NINSVVTSADGE 2313
            +  G+    +    S  E  +  +     + +         + EEM  + N   T +  +
Sbjct: 1002 TEHGERTANEKTTPSPAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVK 1061

Query: 2314 NLEI-QSYSLIGEKLVME-EAKTIVPPHVTDSKRVQKPAIAPPSKW-------NISIFKE 2364
              E  +  +L  EK+ +  E  T      T +     P++A P++        N  I   
Sbjct: 1062 PTEHGEKTTLANEKITLSPEGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSS 1121

Query: 2365 EPRSDQKQKSLLSFDVVDKVPQQP--KSASSNFASKNIT----KESEKPESIILPVEES- 2417
               S + +    S +V+   P +P   +  +  A + +T    K +E PE      E++ 
Sbjct: 1122 AAESTEHRDRATSANVITPAPAEPIKHAKRTTLAHEKMTQVTEKSTEHPEKTTSTTEKTT 1181

Query: 2418 ----KGSLIDFSEDRL-KKEMQNPTSLKISEE--ETKLRSVSPTEKKDNLENRSYTLAEK 2470
                K +L  +SE  +  K    P   K +E    T L + +      + EN   T A  
Sbjct: 1182 RTPEKPTL--YSEKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTENPEKTAAVT 1239

Query: 2471 KVLAEKQNSVAPLEL-RDSNEIGKTQI---------TLGSRSTELKE--SKADAMPQHFY 2518
            K +           L   S+ + KT++         TL +  T+L    S+A     H Y
Sbjct: 1240 KTIKPSVKVTGDKSLTTTSSHLNKTEVTHQVPTGSFTLITSRTKLSSITSEATGNESHPY 1299

Query: 2519 QNEDYNER 2526
             N+D +++
Sbjct: 1300 LNKDGSQK 1307



 Score = 46.2 bits (108), Expect = 7e-04
 Identities = 194/1027 (18%), Positives = 344/1027 (33%), Gaps = 160/1027 (15%)

Query: 2647 ENHSLSQEGNLVLEKSSRDMPDHSE-EKEQFRESELSKG--GSVDITKETVKQGFQEKAV 2703
            EN S   +  ++  + S D  D +   KE   +  ++      ++  K T  +    +  
Sbjct: 123  ENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTTGKSTVTRKS 182

Query: 2704 GTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEK------SSRDMPDH 2757
                RPLE+S   ++KT T      +      N    Q+     EK      ++      
Sbjct: 183  DKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGT 242

Query: 2758 SEEKEQFKESELWKGGSVDITK--ESMKEGFPSKESERTLARPFDETKSSETPPYLLSPV 2815
             EE E+ ++S         +TK  ++++E   + E  ++LA P +    +       SP 
Sbjct: 243  PEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPA 302

Query: 2816 KP----------QTLASGASPEINA---------------VKKKEMPRSELT---PERHT 2847
            +P           T  S A P  N                 + +EM  +E T   P   T
Sbjct: 303  EPTENRERTANENTTLSPAEPIENRERTANENTAPFPAGPTENREMTANENTTLFPAEPT 362

Query: 2848 VHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISN--TSASNAD 2905
             H  +T+ ++T+  P +    ++H    A +     P    +       +N  T++S+A+
Sbjct: 363  EHGERTANENTTPSPAEP---TEHGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAE 419

Query: 2906 KMVSNKEMP----------KEPEDTYAKGEDFTVTSKPAGLSE------DQKTAFSIISE 2949
                 +  P           EP +   +  +   T  PAG +E      ++KT  S + E
Sbjct: 420  STEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTTLSPV-E 478

Query: 2950 GCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKT---------IPLPDDSETVAC 3000
              E     A    +    E +E  Q +  +  EK +  +          PL +++ T + 
Sbjct: 479  PTENRETTANEKTTPSPAEPTENGQ-RTPFANEKTTSSSAEPTEHGERTPLANENTTPSP 537

Query: 3001 HKTL--KSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTL 3058
             +    + R  +EK TP      +   +T      + +T  S  +PT   +   F     
Sbjct: 538  AEPTENRERTANEKTTPSPAEPTENGDRTP---LANEKTTPSLAEPTENGQRTPFANEKT 594

Query: 3059 IDYNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYGP 3118
               +  P   +++ P        L+ E T  + + P  + E              S  GP
Sbjct: 595  TSSSAEPTEHEERTP--------LANENTTPSPAEPTENRERTANE-----NTTPSPAGP 641

Query: 3119 EKGHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTIKVI 3178
             +   + ++ +T          +++ +R  + K+   P    E G  +      TT    
Sbjct: 642  TENREMTANEKT---TLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANEKTTSSSA 698

Query: 3179 DPEFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGTGIYF 3238
            +P    E   LA     L      E +  E TA+E         FP+  ++  + T    
Sbjct: 699  EPTEHGERTPLANENTTLSPAEPTENR--ERTANE-----KTTPFPAEPTENRERTA--- 748

Query: 3239 EKYILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQ 3298
                      ++ +     Q     ++    ++   P  AE    GK      EK+    
Sbjct: 749  ----------NENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTS-- 796

Query: 3299 KGVYGEGESVDHVETV----GNVAMQKKAPITEDVRVATQKISYAVPFEDTHHVLERADE 3354
                   E  +H E       N       P     R A +K +   P E T +    A+E
Sbjct: 797  ----SSAEPTEHAERTPLANENTTSSPAEPTENRERTANEKTT-QFPAEPTENRESTANE 851

Query: 3355 AGS--HGNEVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPSEERL 3412
              +        N     N N  +  + P E       H + T L   K  + P    E  
Sbjct: 852  KTTPFPAEPTENREWTANENTTLSPAEPTE-------HEEMTPLANEKTTLSPAEPTENG 904

Query: 3413 RNSPVQDEYEFTESL----HNEVVPQDILSEELSSESTPEDVLSQGKESFEHISENEFAS 3468
              +P  +E     S     H E  P   L+ E+++ S  E          EH      A+
Sbjct: 905  ERTPFTNEKTTPSSAEPTEHGERTP---LANEITTPSRAEPT--------EH--GERIAN 951

Query: 3469 EAEQSTPAEQKELGSERKEEDQL-SSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVF 3527
            E    +PA+  E G     ED   SS   TE  ++    ++      T   P  +T+   
Sbjct: 952  EKATPSPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANE-----NTTTSPTESTE--- 1003

Query: 3528 GTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKR 3587
              H +   +   T   A   +  E   +  EK++   A  +E E    +  EN + +  +
Sbjct: 1004 --HGERTANEKTTPSPAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVK 1061

Query: 3588 LEEQNEE 3594
              E  E+
Sbjct: 1062 PTEHGEK 1068


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 548/2757 (19%), Positives = 1025/2757 (37%), Gaps = 417/2757 (15%)

Query: 1072 MSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHL 1131
            +S L+DL       KSE+  ++      +    E  IL Q++K +  LE E ++L     
Sbjct: 699  ISKLKDLQQSLVNSKSEEMTLQ-----INELQKEIEILRQEEKEKGTLEQEVQEL--QLK 751

Query: 1132 TSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALT 1191
            T  +EK  +E  + +    A L A++SI+K+E K  +   +L    P + +E+      +
Sbjct: 752  TELLEKQMKEKENDLQEKFAQLEAENSILKDEKK--TLEDMLKIHTP-VSQEERLIFLDS 808

Query: 1192 LKAADEQMALSKVRKEEIVPDSQEATAHVSQ-DQKMEPQ-----------PPNVPESEMK 1239
            +K+  +     K   E ++ ++++      Q ++++E Q             N  E + +
Sbjct: 809  IKSKSKDSVWEK-EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEE 867

Query: 1240 YSVLPDMVDEPKKGVKPKLVLNVTSEL----EQRKLSKNEPEVIKPYSPLKETSLSGPEA 1295
            Y+ L  + D+ +   K K  L   S+L    E+  L +  P  +K    +K +     + 
Sbjct: 868  YACLLKVKDDLEDS-KNKQELEYKSKLKALNEELHLQRINPTTVK----MKSSVFDEDKT 922

Query: 1296 LSAVKMEMKHDSKITTTPIV------------LHSASSGVEKQVEHGPPALAFSALSEEI 1343
              A  +EM    +  TT ++            L    S + +Q++     ++F  L+EE+
Sbjct: 923  FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISF--LNEEV 980

Query: 1344 KKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPL 1403
             K ++      +    +L+  +     E + +  + ++ +   V+T   +G  GS +  +
Sbjct: 981  -KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGS-VSKV 1038

Query: 1404 VTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEV 1463
              S  E S +  EDKV+ +  +  E S         ++++  D LPSV+  +        
Sbjct: 1039 NKSFGEESKIMVEDKVSFENMTVGEESK--------QEQLILDHLPSVTKESSLRATQPS 1090

Query: 1464 EAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDS--ERLVSSQKKSLMSTSE 1521
            E  +++  L V+K+  +    + E  R+     L++ST  D   E + + + K+L S  E
Sbjct: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRI--CLSLVYSTHVDQVREYMENEKDKALCSLKE 1148

Query: 1522 VLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHI-IPKGKDEETASSSPELENLASGL 1580
             L    E  +    +I + E +   +Q      K + +  GK ++  S         S  
Sbjct: 1149 ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE------CSYF 1202

Query: 1581 APTLLLLSDDKNKPAVEVSSTAQ-----GDFPSEKQDVALAELSLEPEKKDKPHQPLELP 1635
              TL  +  +   PA++    A+     GD+ SE +D  L +   E +   +    L L 
Sbjct: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTL-LN 1261

Query: 1636 NAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRELCASSTMP 1695
                E++  L  Q     T+ +K    +T+   LE G   L     KEE   L   S M 
Sbjct: 1262 KVTEEYNKLLVLQ-----TRLSKIWGQQTDGMKLEFGEENL----PKEETEFLSIHSQMT 1312

Query: 1696 AI--------SELSSL--LREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQPFT 1745
             +        S+LSSL  L +    E+++     I SL+ +       E     E     
Sbjct: 1313 NLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ---LKETEQNYEAEIHCLQ 1369

Query: 1746 FSLKGLSEEV---SHPADFKKGGNQEI-GPLPPTGNLKAQVMGDILDKLSEETGHPNSSQ 1801
              L+ +SE     S P D       +    + P   +K  + G I  + S E G    + 
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETN 1427

Query: 1802 VLQSI---------TEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIK 1852
            +++ +          E +K+  S  +   ++TE +      +     +T+S  +     +
Sbjct: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELS-----RISGGKENTASSKQAHAVCQ 1482

Query: 1853 QFSLMRENLPLEQSK-SFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIA 1911
            Q       + L Q +  F T +  DV   K +E F     E    GK   +++     I 
Sbjct: 1483 QEQHYFNEMKLSQDQIGFQTFETVDV---KFKEEFKPLSKELGEHGKEILLSNSDPHDIP 1539

Query: 1912 GSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGN 1971
             S     + S E+          SKD T  VR+ +     +E  +SS +A   L  +   
Sbjct: 1540 ESKDCVLTISEEM---------FSKDKTFIVRQSI----HDEISVSSMDASRQLMLNEEQ 1586

Query: 1972 TETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWP 2031
             E +  +     + +  ++   L+   ++ +   + ++   L E     +++ N +L+  
Sbjct: 1587 LEDMRQELV--RQYQEHQQATELLRQAHMRQMERQREDQEQLQEE----IKRLNRQLAQR 1640

Query: 2032 SKEDSQEKIK-----LPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAE--GVEPALG 2084
            S  D++  +      L  E    K +S    E++  E  +SS +T +       VE    
Sbjct: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTF 1700

Query: 2085 NEKEAHRSTPPFPEEKPLEESKMVQ---SKVIDDADEGKKPSPEVKIPTQRKPISSIHAR 2141
             EKE  R     P E    E   +Q   ++++    E  K +  V+  T  + +  I  R
Sbjct: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE-ETIGRHVLGILDR 1759

Query: 2142 EPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDN------K 2195
              +S  S  +      +  V K  + EE  +    S  S     + GS  P N      K
Sbjct: 1760 SSKSQSSASLIWRSEAEASV-KSCVHEEHTRVTDESIPS-----YSGSDMPRNDINMWSK 1813

Query: 2196 VAEQEDLETQPSPSVEKAVTVIDPEG-----TIPTNFNVAEKPADHSLSEV--KLKTADE 2248
            V E+    +Q       A T IDPE       I +    A +    ++SE   +L+ A  
Sbjct: 1814 VTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKV 1873

Query: 2249 PRGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSRE----DYGKKE--ISGDSEEMN 2302
             +  L++    Q  +E +  L   E+L++       +RE    +  K E  I G ++E  
Sbjct: 1874 TQTELMRESFRQK-QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKT 1932

Query: 2303 I--------NSVVTSADGE---------NLEIQSYSLIGEKLVMEEAKTIVPPHV--TDS 2343
            +          ++   + E          LE +   +  E+ ++   K  +       + 
Sbjct: 1933 LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ 1992

Query: 2344 KRVQKPAIAPPSKWNISIFKEEPRSD-QKQKSLLSFDVVDKV------PQQPKSASSNFA 2396
            + +Q+       K  +    E+ R D QKQ   L  DV ++V       Q+  +   +  
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLR 2052

Query: 2397 SKN--ITKESEKPESIILPVEESKGSLIDFSEDRLKKEMQN----PTSLKISEEETKLRS 2450
             +N  + K+ EK    +      +    D  +  ++K  Q     P    ISE +T+   
Sbjct: 2053 QQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVE 2112

Query: 2451 VSPTEKKDNLENRSYTLAEKKVL----AEKQNSVAPLELRDSNEIGKTQITLGSRSTELK 2506
                  K+  +  S  L  K+ L     E+   +  LE R   E+ +  +       +++
Sbjct: 2113 QLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR-VRELEQALLVSADTFQKVE 2171

Query: 2507 ESK----ADAMPQHFYQNEDYNERPKIIVGSEKEKG----EEKENQVYVLSEGKK---QQ 2555
            + K     +A P+   + +   ER  I     KEK     EE+  Q     E K    QQ
Sbjct: 2172 DRKHFGAVEAKPELSLEVQLQAERDAI---DRKEKEITNLEEQLEQFREELENKNEEVQQ 2228

Query: 2556 EHQPYSVNVAESMSRESDI------------SLGHSLGETQSFS-------LVKATSVTE 2596
             H    +   ES +R  ++             LG ++ E+ + S         K   + +
Sbjct: 2229 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2288

Query: 2597 KSEA---MLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLS- 2652
            + E     L E   ++++   + T    +EE   L+   +T +   +S ++ ++ +    
Sbjct: 2289 EKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEE 2348

Query: 2653 -QEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLE 2711
             ++ N V+EK  +++ +  ++      S         +++E      Q   V  +   LE
Sbjct: 2349 IEQLNEVIEKLQQELANIGQKTSMNAHS---------LSEEADSLKHQLDVVIAEKLALE 2399

Query: 2712 ESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWK 2771
            +      +  TF+  VL            +E N  + + ++++     E+E  ++ +   
Sbjct: 2400 QQVETANEEMTFMKNVL------------KETNFKMNQLTQELFSLKRERESVEKIQSIP 2447

Query: 2772 GGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTLASGASPEIN-- 2829
              SV++  + + +  P  E   T     D  KS E   Y  S  +     +G    IN  
Sbjct: 2448 ENSVNVAIDHLSKDKPELEVVLT----EDALKSLENQTYFKSFEE-----NGKGSIINLE 2498

Query: 2830 --------AVKKKEMPRSELTPERHTVHTIQ-TSKDDTSDVPKQSVLVSKHHLEAAEDTR 2880
                     V  K++   ELT     +  +Q   + +T  + K+ V + K   E      
Sbjct: 2499 TRLLQLESTVSAKDL---ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAAL 2555

Query: 2881 VKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQ 2940
            V +    A   YA+F  +           N+ +  EPE T  +  +     +   L  D 
Sbjct: 2556 VSQIQLEAVQEYAKFCQD-----------NQTISSEPERTNIQNLN---QLREDELGSDI 2601

Query: 2941 KTAFSIISE-GCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVA 2999
                  ISE   +++ +H     S I ++E  ++ +K    +EK   +   L + +E   
Sbjct: 2602 SALTLRISELESQVVEMHT----SLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK-- 2655

Query: 3000 CHKTLKSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLI 3059
                 K R +++K +P    +  E  KT  E+   +E    F +      E    K  L 
Sbjct: 2656 -----KQREKEKKRSP----QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELA 2706

Query: 3060 DYNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVE----------SALEHEYDL- 3108
             Y       K+KA +KL  EE L KE    ++   +S V           S LE E +  
Sbjct: 2707 SY-------KEKA-EKLQ-EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757

Query: 3109 --------------VKLDESFYGPEKGH-NILSHPETQSQNSADRNVSKDTKRDVDSKSP 3153
                          +KL +S      G   I S  +T      +  +  + + +  S+  
Sbjct: 2758 VQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817

Query: 3154 GMPLFEAEEGVLSRTQIFPTTIKVIDPEFLEEPPALA---FLYKDLYEEAVGEKK----- 3205
               + +  E +    ++    I  ++   + E   L    ++   L +E  G  K     
Sbjct: 2818 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQC 2877

Query: 3206 -KEEETASEGDSVNSEA----SFPSRNSDTDDGTGIYFEKYILKDDILHDTSLTQKDQGQ 3260
             + +E +S  +  +S+A       S +S +D G GIY         + H        +G+
Sbjct: 2878 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIY---------LTHSQGFDIASEGR 2928

Query: 3261 GLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQKGVYGEGESVDHVETVGNVAMQ 3320
            G  E+     DS+ P   +G +        +  SL E     GE  S+  V         
Sbjct: 2929 G--EESESATDSF-PKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV--------- 2976

Query: 3321 KKAPITEDVRVATQKISYAVPFEDTHHVLERADEAGSHGNEVGNASPEVNLNVPVQVSFP 3380
               P  E+ +     IS          +   A+   S  +    +     L + +Q  F 
Sbjct: 2977 -SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFL 3035

Query: 3381 EE-EFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSE 3439
            EE      A   + T+L     +      E+R++   V  EY+       +   + +LSE
Sbjct: 3036 EERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGV--EYQAAMECLQKADRRSLLSE 3093

Query: 3440 --ELSSESTPEDVLSQGKESFEHISEN--EFASEAEQSTPAE-QKELGSERKEEDQLSSE 3494
               L ++     +  + ++  E  S+   E+  + +QS   E Q EL S +    +L  +
Sbjct: 3094 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3153

Query: 3495 VVTEK-AQKELKKSQIDTYCYTCKCPISATDKVFGTH-KDHEVSTLDTAISAVKVQLA-E 3551
            + +EK    ELK     T     K  +  T K    H K+ E   L+      +V L  +
Sbjct: 3154 LSSEKMVVAELKSELAQT-----KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLND 3208

Query: 3552 FLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQ 3608
             L + Q+KS        E++      +    ++E+R +E+ E++   + +Q     Q
Sbjct: 3209 TLASEQKKS-------RELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258



 Score = 52.4 bits (124), Expect = 9e-06
 Identities = 92/473 (19%), Positives = 183/473 (38%), Gaps = 77/473 (16%)

Query: 3343 EDTHHVLERADEAGSHGNEVGNASPEVNLNVPVQVSFPEEEFASGATHVQETS--LEEPK 3400
            E+   + +R   +G  G E+   + E+ LN+  ++    E+       + ETS  LE  K
Sbjct: 1816 EEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA---ISETSSQLEHAK 1872

Query: 3401 I----LVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKE 3456
            +    L+     +++     ++ + E  E LH E   ++ L+ ELS      D  +  K 
Sbjct: 1873 VTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKT 1932

Query: 3457 SFEH------------------ISENEFASEAEQSTPAEQKELGSERKEEDQLSSEVVTE 3498
             FE                    S      EAEQ    E++EL S +KE  +  +  V +
Sbjct: 1933 LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ 1992

Query: 3499 KAQKE---LKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLEN 3555
            +  +E   L K +++  C   K       +V     D            V+ Q++ F+E 
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEID------------VEEQVSRFIEL 2040

Query: 3556 LQEKSLRI-------EAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQ 3608
             QEK+  +       +A   ++E     ++E     E   +   +E+ K  L Q  +   
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQK--LEQQLKVVP 2098

Query: 3609 SFEEVKKKKMEFLHEQMVHFLQSMDTAKDTL---ETIVREAEELDEAVFLTSF--EEINE 3663
             F+ + + +   + +   H  +  D   + L   E + R+ +E +E +    F   E+ +
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158

Query: 3664 RLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPNSATSTTI 3723
             LL + ++   +E         +H+    A+ +  L+     +   ++ +E         
Sbjct: 2159 ALLVSADTFQKVEDR-------KHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT----- 2206

Query: 3724 AVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPD 3776
                  N E+ ++ F+    E    ++EV +L  +  +  KES    ++LE +
Sbjct: 2207 ------NLEEQLEQFR---EELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2250



 Score = 40.4 bits (93), Expect = 0.036
 Identities = 67/310 (21%), Positives = 129/310 (41%), Gaps = 36/310 (11%)

Query: 3382 EEFASGATHVQETSLEEPKILVPPEPSE-----ERLRNSPVQDEYEFTESLHNEVVP-QD 3435
            EE   G+    ET L + +  V  +  E     +++++   Q ++E TE L  ++V  Q 
Sbjct: 2487 EENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE-TEMLQKKIVNLQK 2545

Query: 3436 ILSEELSSESTPEDVLSQGKESFEHISENEFASEAEQSTPAE------QKELGSERK--- 3486
            I+ E++++    +  L   +E  +   +N+  S   + T  +      + ELGS+     
Sbjct: 2546 IVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALT 2605

Query: 3487 -EEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAV 3545
                +L S+VV       L+K Q++           A   V    K+ ++  L   +   
Sbjct: 2606 LRISELESQVVEMHTSLILEKEQVEI----------AEKNVL--EKEKKLLELQKLLEGN 2653

Query: 3546 KVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDE 3605
            + +  E  +    + + +    +E+   F++ EE+   NE           K  LA Y E
Sbjct: 2654 EKKQREKEKKRSPQDVEVLKTTTEL---FHSNEESGFFNELEALRAESVATKAELASYKE 2710

Query: 3606 KAQSFEE---VKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAE-ELDEAVFLTSFEEI 3661
            KA+  +E   VK+  M  L + +      +  AK+ L  + +E E E+ E+     FE +
Sbjct: 2711 KAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2770

Query: 3662 NERLLSAMES 3671
              +L  ++ S
Sbjct: 2771 PIKLSKSIAS 2780



 Score = 39.7 bits (91), Expect = 0.062
 Identities = 185/970 (19%), Positives = 363/970 (37%), Gaps = 100/970 (10%)

Query: 2763 QFKESELWKGGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTLAS 2822
            QF++ +    G     K+  K    S + + +     +  +S     Y+ S  + ++   
Sbjct: 19   QFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVI 78

Query: 2823 GASPEINAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVK 2882
              S  +  +   E+   E          I T+ DD S        V +          ++
Sbjct: 79   PESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMR---TGKPTNLLR 135

Query: 2883 EPLSSAKSNYAQFISNTSASNADKMVSNKEMPK-EPEDTYAKGEDFTVTSKPAGLSEDQK 2941
            E       +Y++  +  S ++ + M S     + E E+   + E+  VT    GL + Q+
Sbjct: 136  EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQE 195

Query: 2942 TAFSIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVACH 3001
               +I      I  + A   +    +E+ E M++ LE  E+    +        + +   
Sbjct: 196  FEAAIKQRDGIITQLTAN--LQQARREKDETMREFLELTEQSQKLQI-----QFQQLQAS 248

Query: 3002 KTLKSRLEDEKVTPLKENKQKE-THKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLID 3060
            +TL++         L + KQ+  TH+ + E     E D   ++     +ED+  + + + 
Sbjct: 249  ETLRNSTHSSTAADLLQAKQQILTHQQQLE-----EQD-HLLEDYQKKKEDFTMQISFLQ 302

Query: 3061 YNISP-DPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYGPE 3119
              I   + E+ K  +  N EE   KE   E ++  +   E       D +   +   G  
Sbjct: 303  EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362

Query: 3120 KGHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTI-KVI 3178
            +   +  + E ++      N  +  ++  +     M   E  +    +   F T I + +
Sbjct: 363  QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422

Query: 3179 DPEFLEEPPALAFLYKDLYEEAVGEKKKE-----------EETASEGDSVNSEASFPSR- 3226
            + E   +   L     ++Y + + + K+E            +T  +G+  N+  S+ +  
Sbjct: 423  EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482

Query: 3227 -NSDTDDGTGIYFEKYILKDDILHDTSLTQKDQ-----GQGLEEK----RVGKDDSYQPI 3276
             N D      +   +  +K   L DT+ +QK++     G  LEEK    R  +D   +  
Sbjct: 483  VNEDQIKLMNVAINELNIK---LQDTN-SQKEKLKEELGLILEEKCALQRQLEDLVEELS 538

Query: 3277 AAEGEIWGKFGTICREKS-LEEQKGVYGEGESVDHVETVGNVAMQKKAPITEDVRVATQK 3335
             +  +I     TI  ++S L E        E +   E V     +K+  +  +  V   K
Sbjct: 539  FSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK-AEIVSASESRKELELKHEAEVTNYK 597

Query: 3336 ISYAVPFEDTHHVLERADEAGSHGNEVGNASPEVNLN-VPVQVSFPEEEFASGATHVQET 3394
            I   +  ++ + VL+R  E           S E  L  +  Q+ F  EE  S      E 
Sbjct: 598  IKLEMLEKEKNAVLDRMAE-----------SQEAELERLRTQLLFSHEEELSKLKEDLEI 646

Query: 3395 ----SLEEPK--ILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSEELSSESTPE 3448
                ++E+ K  + +  +   + L+N   Q          N +  Q+ L  E+S     +
Sbjct: 647  EHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQ 706

Query: 3449 DVLSQGKESFEHISENEFASEAEQSTPAEQKELGSERKEEDQLSSEVVTEKAQKELKK-- 3506
              L   K     +  NE   E E     E+KE G+  +E  +L  ++ TE  +K++K+  
Sbjct: 707  QSLVNSKSEEMTLQINELQKEIE-ILRQEEKEKGTLEQEVQEL--QLKTELLEKQMKEKE 763

Query: 3507 -------SQIDTYCYTCKCPISATDKVFGTH----KDHEVSTLDTAISAVKVQ------- 3548
                   +Q++      K      + +   H    ++  +  LD+  S  K         
Sbjct: 764  NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIE 823

Query: 3549 -LAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKA 3607
             L E  E+L+++ +++   + +  + F+  E+N   N + L+E+   ++K      D K 
Sbjct: 824  ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883

Query: 3608 QSFEEVKKKKM---EFLHEQMVH--FLQSMDTAKDTLETIVREAEELDEAVFLTSFEEIN 3662
            +   E K K     E LH Q ++   ++   +  D  +T V E  E+ E V     E+  
Sbjct: 884  KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV-----EKDT 938

Query: 3663 ERLLSAMEST 3672
              L+  +E T
Sbjct: 939  TELMEKLEVT 948



 Score = 36.6 bits (83), Expect = 0.52
 Identities = 57/243 (23%), Positives = 100/243 (41%), Gaps = 44/243 (18%)

Query: 1901 NVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHS---------A 1951
            N+  +  Q +   V+L S      R  +L+  +SS+       K  L  +         A
Sbjct: 3125 NIQQKQSQMLEMQVELSSMKD---RATELQEQLSSEKMVVAELKSELAQTKLELETTLKA 3181

Query: 1952 EESHLSSQEAV-----SALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAE 2006
            +  HL   EA         D      +TL+S+   S E++ A E +   L  + ER+  E
Sbjct: 3182 QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEE 3241

Query: 2007 GKEIHSLMESE-------SLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQ 2059
             +++   +ES+       +LLLE+    L+     +SQ+KI+   +R      + LS EQ
Sbjct: 3242 LEDLKFSLESQKQRNLQLNLLLEQQKQLLN-----ESQQKIE--SQRMLYD--AQLSEEQ 3292

Query: 2060 VKSETISSSVKTAHFPAEGVEPALGNEKEAH----------RSTPPFPEEKPLEE-SKMV 2108
             ++  +   +++       +   L  E+E H          +S PP P E  L+E  K +
Sbjct: 3293 GRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3352

Query: 2109 QSK 2111
            + K
Sbjct: 3353 EEK 3355



 Score = 35.0 bits (79), Expect = 1.5
 Identities = 88/369 (23%), Positives = 151/369 (40%), Gaps = 91/369 (24%)

Query: 3365 ASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDEYEFT 3424
            A PE++L V +Q     E  A      + T+LEE       E   E L N     + E  
Sbjct: 2181 AKPELSLEVQLQA----ERDAIDRKEKEITNLEEQL-----EQFREELEN-----KNEEV 2226

Query: 3425 ESLHNEVVPQDILS----EELSSEST--PEDVLSQG---KESFEHISENEFASEAEQSTP 3475
            + LH ++  Q   S    +EL  E+    +D+   G   KES    ++++     + +  
Sbjct: 2227 QQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2286

Query: 3476 AEQKELGSERKEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEV 3535
             ++KE+     E DQL+ +V   K Q++LK              I+  +KV    K+  +
Sbjct: 2287 IQEKEV-----EIDQLNEQVT--KLQQQLK--------------ITTDNKVI-EEKNELI 2324

Query: 3536 STLDTAISAVK--------------VQLAEFLENLQEK--------SLRIEAFVSEIESF 3573
              L+T I  +                QL E +E LQ++        S+   +   E +S 
Sbjct: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2384

Query: 3574 FNTIEENCSKN---EKRLEEQNEEM--MKKVLAQYDEKAQSF---------EEVKKKKME 3619
             + ++   ++    E+++E  NEEM  MK VL + + K             E    +K++
Sbjct: 2385 KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQ 2444

Query: 3620 FLHEQMVHF-LQSMDTAKDTLETIVRE--AEELDEAVFLTSFEE------IN-ERLLSAM 3669
             + E  V+  +  +   K  LE ++ E   + L+   +  SFEE      IN E  L  +
Sbjct: 2445 SIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQL 2504

Query: 3670 ESTASLEKM 3678
            EST S + +
Sbjct: 2505 ESTVSAKDL 2513


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.123    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 165,752,367
Number of Sequences: 37866
Number of extensions: 8503267
Number of successful extensions: 41052
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 1396
Number of HSP's that attempted gapping in prelim test: 27213
Number of HSP's gapped (non-prelim): 12880
length of query: 4069
length of database: 18,247,518
effective HSP length: 123
effective length of query: 3946
effective length of database: 13,590,000
effective search space: 53626140000
effective search space used: 53626140000
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.