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Search of human proteins with 62198235
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62198235 drebrin-like isoform b [Homo sapiens]
(430 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62198235 drebrin-like isoform b [Homo sapiens] 874 0.0
gi|21361670 drebrin-like isoform a [Homo sapiens] 869 0.0
gi|171906575 drebrin-like isoform c [Homo sapiens] 862 0.0
gi|18426915 drebrin 1 isoform a [Homo sapiens] 215 7e-56
gi|18426913 drebrin 1 isoform b [Homo sapiens] 198 7e-51
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 105 8e-23
gi|20357552 cortactin isoform a [Homo sapiens] 101 1e-21
gi|20357556 cortactin isoform b [Homo sapiens] 101 1e-21
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 64 2e-10
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 64 2e-10
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 64 2e-10
gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 63 6e-10
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 61 2e-09
gi|115527120 nebulin [Homo sapiens] 56 6e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 56 7e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 56 7e-08
gi|47087157 nebulette non-muscle isoform [Homo sapiens] 54 3e-07
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 54 3e-07
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 53 5e-07
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 53 6e-07
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 53 6e-07
gi|148747351 protein kinase C and casein kinase substrate in neu... 53 6e-07
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 52 1e-06
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 52 1e-06
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 52 1e-06
gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo sap... 52 1e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 52 1e-06
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 52 1e-06
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 52 1e-06
gi|24308229 protein kinase C and casein kinase substrate in neur... 51 2e-06
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 874 bits (2257), Expect = 0.0
Identities = 430/430 (100%), Positives = 430/430 (100%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ 240
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ 240
Query: 241 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE 300
QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE
Sbjct: 241 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE 300
Query: 301 PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI 360
PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI
Sbjct: 301 PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI 360
Query: 361 DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM 420
DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM
Sbjct: 361 DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM 420
Query: 421 FPANYVELIE 430
FPANYVELIE
Sbjct: 421 FPANYVELIE 430
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 869 bits (2245), Expect = 0.0
Identities = 430/431 (99%), Positives = 430/431 (99%), Gaps = 1/431 (0%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ-RTWEQ 239
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ RTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
Query: 240 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR 299
QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR
Sbjct: 241 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR 300
Query: 300 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 359
EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH
Sbjct: 301 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 360
Query: 360 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG 419
IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG
Sbjct: 361 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG 420
Query: 420 MFPANYVELIE 430
MFPANYVELIE
Sbjct: 421 MFPANYVELIE 431
>gi|171906575 drebrin-like isoform c [Homo sapiens]
Length = 439
Score = 862 bits (2226), Expect = 0.0
Identities = 430/439 (97%), Positives = 430/439 (97%), Gaps = 9/439 (2%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ-RTWEQ 239
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ RTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
Query: 240 QQEVVSRNRNE--------QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 291
QQEVVSRNRNE QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT
Sbjct: 241 QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 300
Query: 292 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 351
QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ
Sbjct: 301 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 360
Query: 352 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 411
QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG
Sbjct: 361 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420
Query: 412 YGPDGHFGMFPANYVELIE 430
YGPDGHFGMFPANYVELIE
Sbjct: 421 YGPDGHFGMFPANYVELIE 439
>gi|18426915 drebrin 1 isoform a [Homo sapiens]
Length = 649
Score = 215 bits (547), Expect = 7e-56
Identities = 130/372 (34%), Positives = 201/372 (54%), Gaps = 44/372 (11%)
Query: 3 ANLSRNGPALQ--EAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
A +S +G L+ AY V+ E+S DWAL+TYE S+D+++A +GEGGL+E+ +
Sbjct: 2 AGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQ 61
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMY FC VKD + LPK+VLINW GE V D RK ACASHV+ +A F +G V +NA +
Sbjct: 62 KVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSV 121
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
ED++ I ++++ S R ++ PVG+ YQKT+A E+KR+ ++ FW
Sbjct: 122 EDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFW 181
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQ- 239
+A+KEEE R+ EE+++A + + + EQER E+E +E RE+RY+E+ + R +Q
Sbjct: 182 EQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQT 241
Query: 240 -----------QQEVVSRNRNEQESA--------------------VHPREIFKQKERAM 268
+Q + +R+E+E +PRE FKQ+ER
Sbjct: 242 LEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVA 301
Query: 269 STTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPC--LV 326
S ++ S P SPF + + ++H P +R P++ STP +
Sbjct: 302 SASAGSCDVP----SPFNHRPGSHLDSHRRMAPTPIPTRS----PSDSSTASTPVAEQIE 353
Query: 327 QAEEEAVYEEPP 338
+A +E +PP
Sbjct: 354 RALDEVTSSQPP 365
>gi|18426913 drebrin 1 isoform b [Homo sapiens]
Length = 651
Score = 198 bits (504), Expect = 7e-51
Identities = 119/344 (34%), Positives = 185/344 (53%), Gaps = 42/344 (12%)
Query: 29 ALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEG 88
AL+TYE S+D+++A +GEGGL+E+ + KVMY FC VKD + LPK+VLINW GE
Sbjct: 32 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 91
Query: 89 VNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGR 148
V D RK ACASHV+ +A F +G V +NA + ED++ I ++++ S R
Sbjct: 92 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 151
Query: 149 FQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
++ PVG+ YQKT+A E+KR+ ++ FW +A+KEEE R+ EE+++A + + + EQE
Sbjct: 152 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 211
Query: 209 RRERELREAARREQRYQEQGGEASPQRTWEQ------------QQEVVSRNRNEQESA-- 254
R E+E +E RE+RY+E+ + R +Q +Q + +R+E+E
Sbjct: 212 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 271
Query: 255 ------------------VHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 296
+PRE FKQ+ER S ++ S P SPF + + ++H
Sbjct: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVP----SPFNHRPGSHLDSH 327
Query: 297 FGREPAAAISRPRADLPAEEPAPSTPPC--LVQAEEEAVYEEPP 338
P +R P++ STP + +A +E +PP
Sbjct: 328 RRMAPTPIPTRS----PSDSSTASTPVAEQIERALDEVTSSQPP 367
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 105 bits (262), Expect = 8e-23
Identities = 102/343 (29%), Positives = 138/343 (40%), Gaps = 92/343 (26%)
Query: 133 AKASGANYSFHKESGRFQDVG---PQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEEN 189
AK G Y K+ VG +AP + Y+KT + E G AK E E
Sbjct: 191 AKGFGGQYGIQKDRVDKSAVGFNEMEAPT-TAYKKTTPI-EAASSGTRGLKAKFESMAEE 248
Query: 190 RRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRN 249
+R KR EE +Q+ + ++ER+ A +R+ E Q V+
Sbjct: 249 KR---KREEEEKAQQVARRQQERK-----------------AVTKRSPEAPQPVI----- 283
Query: 250 EQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF-----GREPAAA 304
AM ++ +P P K+ S T P + RE
Sbjct: 284 -----------------AMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVP 326
Query: 305 ISRPRADLPAE-EPAPSTPPCLV---QAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI 360
+ R LP + E P+ PP + Q EEE VYE PE E E P + E +
Sbjct: 327 LLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEP--EPEPEPENDYEDVEEM 384
Query: 361 DHHIQ---------------------------------GQGLSGQGLCARALYDYQAADD 387
D H Q G G G+ A ALYDYQ
Sbjct: 385 DRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGS 444
Query: 388 TEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE 430
E+SFDP+++IT IE++DEGWWRG GHFG+FPANYV+L+E
Sbjct: 445 DELSFDPDDVITDIEMVDEGWWRG-RCHGHFGLFPANYVKLLE 486
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 101 bits (252), Expect = 1e-21
Identities = 92/303 (30%), Positives = 128/303 (42%), Gaps = 64/303 (21%)
Query: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEE 187
+K G Y K+ + F+DV V S YQKT V + +K
Sbjct: 303 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVT--------SKTSNIR 351
Query: 188 ENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRN 247
N K + +E +R+ E ER +R +E
Sbjct: 352 ANFENLAKEKEQEDRRKAEAERAQRMAKE------------------------------- 380
Query: 248 RNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISR 307
R EQE A R +++ RA + T SP P P ++ + P E AA+
Sbjct: 381 RQEQEEA---RRKLEEQARAKTQTPPVSPAP----QPTEERLPSSPVY----EDAASF-- 427
Query: 308 PRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI--DHHIQ 365
+A+L P T P V + E A Y E Q+ V + H +
Sbjct: 428 -KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTY 486
Query: 366 GQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANY 425
+ + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G +G+FPANY
Sbjct: 487 DEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGLFPANY 545
Query: 426 VEL 428
VEL
Sbjct: 546 VEL 548
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 101 bits (252), Expect = 1e-21
Identities = 92/303 (30%), Positives = 128/303 (42%), Gaps = 64/303 (21%)
Query: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEE 187
+K G Y K+ + F+DV V S YQKT V + +K
Sbjct: 266 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVT--------SKTSNIR 314
Query: 188 ENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRN 247
N K + +E +R+ E ER +R +E
Sbjct: 315 ANFENLAKEKEQEDRRKAEAERAQRMAKE------------------------------- 343
Query: 248 RNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISR 307
R EQE A R +++ RA + T SP P P ++ + P E AA+
Sbjct: 344 RQEQEEA---RRKLEEQARAKTQTPPVSPAP----QPTEERLPSSPVY----EDAASF-- 390
Query: 308 PRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI--DHHIQ 365
+A+L P T P V + E A Y E Q+ V + H +
Sbjct: 391 -KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTY 449
Query: 366 GQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANY 425
+ + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G +G+FPANY
Sbjct: 450 DEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGLFPANY 508
Query: 426 VEL 428
VEL
Sbjct: 509 VEL 511
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 64.3 bits (155), Expect = 2e-10
Identities = 63/273 (23%), Positives = 114/273 (41%), Gaps = 35/273 (12%)
Query: 175 GKDSFWA---KAEKEEENRRLEEKRRAEEAQRQLEQ-ERRERELREAARREQRYQEQGGE 230
GK++ W + E+EE+ +RL+E++ E+ Q + + E ++R+ ++ + E++ +E
Sbjct: 672 GKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 731
Query: 231 ASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF----- 285
R + RN E + + +I + E+ + +PG L F
Sbjct: 732 LVNYRALYPFEA-----RNHDEMSFNSGDIIQVDEKTVG-------EPGWLYGSFQGNFG 779
Query: 286 -----LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEEAVYEE 336
+++ E P A+ P L A EP S P V + +
Sbjct: 780 WFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 839
Query: 337 PPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPEN 396
++ ++ + GS H GQG + L A+AL + A D ++F +
Sbjct: 840 LTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLNFSKHD 896
Query: 397 LITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 429
+IT +E E WW G G G FP +YV++I
Sbjct: 897 IITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 927
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 378 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 428
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1156
Score = 43.5 bits (101), Expect = 4e-04
Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQER---RERELREAARREQRYQEQGGEASPQRTWE 238
KA E N LE++R+A Q+Q E ER +E+E E +RE + QE + ++ E
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 239 QQQEVVSRNRNEQESAVHPREIFKQK 264
+Q+E+ + E+ + RE KQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQE 453
Score = 37.0 bits (84), Expect = 0.035
Identities = 37/157 (23%), Positives = 70/157 (44%), Gaps = 29/157 (18%)
Query: 162 YQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE------------R 209
Y++ N E +R + + ++E E + +EK E QR+L+++
Sbjct: 371 YERGNMELEKRR---QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 210 RERELREAARREQRYQEQGGEASPQR-------TWE--QQQEVVSRNRNEQESAVHPREI 260
++REL E+R + EA+ Q WE ++QE++++ EQE V R
Sbjct: 428 KQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIV--RLN 485
Query: 261 FKQKERAMSTTSISSPQ---PGKLRSPFLQKQLTQPE 294
K+K + +++ G+L+ L+KQ + E
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
Score = 36.2 bits (82), Expect = 0.059
Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQR 235
+ K ++EE ++L E+KR+A + +E E+R + L E +RE + Q + +R
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 236 TWEQQQEVVSRNRNEQESAVH-PREIFKQKE 265
+ QE + + E E + RE+ +Q+E
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRELERQRE 437
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 382 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 429
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1088
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 64.3 bits (155), Expect = 2e-10
Identities = 63/273 (23%), Positives = 114/273 (41%), Gaps = 35/273 (12%)
Query: 175 GKDSFWA---KAEKEEENRRLEEKRRAEEAQRQLEQ-ERRERELREAARREQRYQEQGGE 230
GK++ W + E+EE+ +RL+E++ E+ Q + + E ++R+ ++ + E++ +E
Sbjct: 699 GKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 758
Query: 231 ASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF----- 285
R + RN E + + +I + E+ + +PG L F
Sbjct: 759 LVNYRALYPFEA-----RNHDEMSFNSGDIIQVDEKTVG-------EPGWLYGSFQGNFG 806
Query: 286 -----LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEEAVYEE 336
+++ E P A+ P L A EP S P V + +
Sbjct: 807 WFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 866
Query: 337 PPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPEN 396
++ ++ + GS H GQG + L A+AL + A D ++F +
Sbjct: 867 LTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 397 LITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 429
+IT +E E WW G G G FP +YV++I
Sbjct: 924 IITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 954
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 378 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 428
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1183
Score = 43.5 bits (101), Expect = 4e-04
Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQER---RERELREAARREQRYQEQGGEASPQRTWE 238
KA E N LE++R+A Q+Q E ER +E+E E +RE + QE + ++ E
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 239 QQQEVVSRNRNEQESAVHPREIFKQK 264
+Q+E+ + E+ + RE KQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQE 453
Score = 37.0 bits (84), Expect = 0.035
Identities = 37/157 (23%), Positives = 70/157 (44%), Gaps = 29/157 (18%)
Query: 162 YQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE------------R 209
Y++ N E +R + + ++E E + +EK E QR+L+++
Sbjct: 371 YERGNMELEKRR---QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 210 RERELREAARREQRYQEQGGEASPQR-------TWE--QQQEVVSRNRNEQESAVHPREI 260
++REL E+R + EA+ Q WE ++QE++++ EQE V R
Sbjct: 428 KQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIV--RLN 485
Query: 261 FKQKERAMSTTSISSPQ---PGKLRSPFLQKQLTQPE 294
K+K + +++ G+L+ L+KQ + E
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
Score = 36.2 bits (82), Expect = 0.059
Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQR 235
+ K ++EE ++L E+KR+A + +E E+R + L E +RE + Q + +R
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 236 TWEQQQEVVSRNRNEQESAVH-PREIFKQKE 265
+ QE + + E E + RE+ +Q+E
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRELERQRE 437
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 382 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 429
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 64.3 bits (155), Expect = 2e-10
Identities = 63/273 (23%), Positives = 114/273 (41%), Gaps = 35/273 (12%)
Query: 175 GKDSFWA---KAEKEEENRRLEEKRRAEEAQRQLEQ-ERRERELREAARREQRYQEQGGE 230
GK++ W + E+EE+ +RL+E++ E+ Q + + E ++R+ ++ + E++ +E
Sbjct: 699 GKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 758
Query: 231 ASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF----- 285
R + RN E + + +I + E+ + +PG L F
Sbjct: 759 LVNYRALYPFEA-----RNHDEMSFNSGDIIQVDEKTVG-------EPGWLYGSFQGNFG 806
Query: 286 -----LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEEAVYEE 336
+++ E P A+ P L A EP S P V + +
Sbjct: 807 WFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 866
Query: 337 PPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPEN 396
++ ++ + GS H GQG + L A+AL + A D ++F +
Sbjct: 867 LTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 397 LITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 429
+IT +E E WW G G G FP +YV++I
Sbjct: 924 IITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 954
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 378 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 428
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1183
Score = 43.5 bits (101), Expect = 4e-04
Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQER---RERELREAARREQRYQEQGGEASPQRTWE 238
KA E N LE++R+A Q+Q E ER +E+E E +RE + QE + ++ E
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 239 QQQEVVSRNRNEQESAVHPREIFKQK 264
+Q+E+ + E+ + RE KQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQE 453
Score = 37.0 bits (84), Expect = 0.035
Identities = 37/157 (23%), Positives = 70/157 (44%), Gaps = 29/157 (18%)
Query: 162 YQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE------------R 209
Y++ N E +R + + ++E E + +EK E QR+L+++
Sbjct: 371 YERGNMELEKRR---QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 210 RERELREAARREQRYQEQGGEASPQR-------TWE--QQQEVVSRNRNEQESAVHPREI 260
++REL E+R + EA+ Q WE ++QE++++ EQE V R
Sbjct: 428 KQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIV--RLN 485
Query: 261 FKQKERAMSTTSISSPQ---PGKLRSPFLQKQLTQPE 294
K+K + +++ G+L+ L+KQ + E
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
Score = 36.2 bits (82), Expect = 0.059
Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQR 235
+ K ++EE ++L E+KR+A + +E E+R + L E +RE + Q + +R
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 236 TWEQQQEVVSRNRNEQESAVH-PREIFKQKE 265
+ QE + + E E + RE+ +Q+E
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRELERQRE 437
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 382 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 429
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
Length = 261
Score = 62.8 bits (151), Expect = 6e-10
Identities = 55/199 (27%), Positives = 84/199 (42%), Gaps = 27/199 (13%)
Query: 246 RNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF-----------LQKQLTQPE 294
+ ++E +S V +E F++ + + +P+ +++ +K P
Sbjct: 75 KQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPS 134
Query: 295 THFGREPAAAISRPRADL--PAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQ 352
G EP S+ + P E+ P P VY++P +Q P+ Q
Sbjct: 135 GGEGMEPERRDSQDGSSYRRPLEQQQPHHIPT-----SAPVYQQPQQQ-------PVAQS 182
Query: 353 QGAGSEHIDH-HIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 411
G E IQ G G RA+YDY AAD+ E+SF + I ++ ID+GW G
Sbjct: 183 YGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYG 242
Query: 412 -YGPDGHFGMFPANYVELI 429
G GM PANYVE I
Sbjct: 243 TVERTGDTGMLPANYVEAI 261
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 60.8 bits (146), Expect = 2e-09
Identities = 50/150 (33%), Positives = 76/150 (50%), Gaps = 25/150 (16%)
Query: 181 AKAEKEEENRRLEEKRRAEEAQ-RQLEQER------------RERELREAARREQRYQEQ 227
A+AE+E E RR EE+ E+AQ Q EQER RE R+ RE+ +Q+Q
Sbjct: 642 ARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQ 701
Query: 228 GGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKL---RSP 284
E +R ++ +E++ R R + S ++ K+ + + SSP+P K RSP
Sbjct: 702 EQERQERR--KRLEEIMKRTRKSEVSETKQKQDSKE-----ANANGSSPEPVKAVEARSP 754
Query: 285 FLQKQLTQPETHFGREPAAAISRPRADLPA 314
LQK+ Q E +EP ++ P +LPA
Sbjct: 755 GLQKEAVQKEEPIPQEPQWSL--PSKELPA 782
Score = 38.1 bits (87), Expect = 0.016
Identities = 24/88 (27%), Positives = 48/88 (54%), Gaps = 5/88 (5%)
Query: 170 EIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARR--EQRYQEQ 227
E+K+ G+ AK +EE + L K+ + + + RE++L+E RR EQR + +
Sbjct: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
Query: 228 GGEASPQRTWEQQQEVVSRNRNEQESAV 255
A+ + E+Q++ + +N+ E+A+
Sbjct: 191 QRRAALE---ERQRQKLEKNKERYEAAI 215
Score = 36.6 bits (83), Expect = 0.045
Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 8/86 (9%)
Query: 176 KDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQ-----EQGGE 230
K + W EKEE+ + L EK+ +E +R+LE++R + E R AA E++ Q ++ E
Sbjct: 156 KKAVWL--EKEEKAKALREKQ-LQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYE 212
Query: 231 ASPQRTWEQQQEVVSRNRNEQESAVH 256
A+ QR+ ++ + + R A+H
Sbjct: 213 AAIQRSVKKTWAEIRQQRWSWAGALH 238
Score = 31.6 bits (70), Expect = 1.5
Identities = 21/105 (20%), Positives = 39/105 (37%)
Query: 219 RREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQP 278
R E+R GG +P R + V + + ++E + +ER++ P
Sbjct: 388 RGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASP 447
Query: 279 GKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPP 323
S +L+ P+ + RP + P+ P + PP
Sbjct: 448 RARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPP 492
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 56.2 bits (134), Expect = 6e-08
Identities = 30/61 (49%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 370 SGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYVEL 428
S G RA+YDY AAD E+SF + I ++ IDEGW G G GM PANYVE
Sbjct: 6609 STAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGRTGMLPANYVEA 6668
Query: 429 I 429
I
Sbjct: 6669 I 6669
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 55.8 bits (133), Expect = 7e-08
Identities = 40/141 (28%), Positives = 66/141 (46%), Gaps = 13/141 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEV 243
+KEEE RL + A+ Q EQERRE+E RE RREQ +EQ +R +++Q
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ------ERREQERQLA 720
Query: 244 VSRNRNEQESAVHPREIFKQKERAMS------TTSISSPQPGKLRSPFLQKQLTQPETHF 297
R EQE RE+ +++E+A+ + + + + ++QL + +
Sbjct: 721 EQERRREQERLQAEREL-QEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 779
Query: 298 GREPAAAISRPRADLPAEEPA 318
+E A A + + PA
Sbjct: 780 AKEAAGASKALNVTVDVQSPA 800
Score = 43.1 bits (100), Expect = 5e-04
Identities = 30/109 (27%), Positives = 60/109 (55%), Gaps = 8/109 (7%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKE--EENRRLEEKRRAE--EAQRQL-EQERRERELREA 217
++ +E KR+ + + E+E E+ RR +E+R E E +RQL EQERR + R
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
Query: 218 ARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKER 266
A RE + +E+ + + Q+E+ + + E++ + R++ +++E+
Sbjct: 733 AERELQEREKALRLQKE---QLQRELEEKKKKEEQQRLAERQLQEEQEK 778
Score = 40.0 bits (92), Expect = 0.004
Identities = 34/127 (26%), Positives = 61/127 (48%), Gaps = 16/127 (12%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERE------------LREAARREQRYQEQGG 229
K E+ E R+ EE+ R +Q E+ERR +E LR+AA ++ +++
Sbjct: 631 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
Query: 230 EASPQRTWEQ---QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPG-KLRSPF 285
E Q EQ +QE + R EQE + +E +++ER + + + +L+
Sbjct: 691 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ 750
Query: 286 LQKQLTQ 292
LQ++L +
Sbjct: 751 LQRELEE 757
Score = 39.7 bits (91), Expect = 0.005
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 17/176 (9%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARR----EQRYQEQGGEASPQRTW 237
K EK +E R EEK + + A +++E+ R+ E ARR +Q +E+ + Q+
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
Query: 238 EQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF 297
E++QE + + + A + +++ER + + R ++QL + E
Sbjct: 669 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQ--ERQLAEQERRR 726
Query: 298 GREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQ 353
+E A +L E A ++ ++E + E E++ EQ L ++Q
Sbjct: 727 EQERLQA----ERELQEREKA-------LRLQKEQLQRELEEKKKKEEQQRLAERQ 771
Score = 35.0 bits (79), Expect = 0.13
Identities = 43/196 (21%), Positives = 84/196 (42%), Gaps = 36/196 (18%)
Query: 186 EEENRRLEEKRRAEEAQ------------RQLEQE--RRERELREAARREQRYQEQGGEA 231
E+E +RLE RR EEA+ R+LE+ +RE LR+ + +R ++ E
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 232 SPQ----------RTWEQQQEVVSRNRNEQESAVHPREIF----KQKERAMSTTSISSPQ 277
Q +T + ++E ++ + ++++A E KQ+E A + +
Sbjct: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
Query: 278 PGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEP 337
+ LQK+ + + + AA ++ A+ +E + E+E +E
Sbjct: 656 EERRHQELLQKKKEEEQERLRK---AAEAKRLAEQREQERREQE-----RREQERREQER 707
Query: 338 PEQETFYEQPPLVQQQ 353
EQE ++ L +Q+
Sbjct: 708 REQERREQERQLAEQE 723
Score = 35.0 bits (79), Expect = 0.13
Identities = 18/40 (45%), Positives = 27/40 (67%), Gaps = 3/40 (7%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLE---QERRERELREAA 218
+ +KE+ R LEEK++ EE QR E QE +E++ +EAA
Sbjct: 745 RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 55.8 bits (133), Expect = 7e-08
Identities = 40/141 (28%), Positives = 66/141 (46%), Gaps = 13/141 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEV 243
+KEEE RL + A+ Q EQERRE+E RE RREQ +EQ +R +++Q
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ------ERREQERQLA 716
Query: 244 VSRNRNEQESAVHPREIFKQKERAMS------TTSISSPQPGKLRSPFLQKQLTQPETHF 297
R EQE RE+ +++E+A+ + + + + ++QL + +
Sbjct: 717 EQERRREQERLQAEREL-QEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 775
Query: 298 GREPAAAISRPRADLPAEEPA 318
+E A A + + PA
Sbjct: 776 AKEAAGASKALNVTVDVQSPA 796
Score = 43.1 bits (100), Expect = 5e-04
Identities = 30/109 (27%), Positives = 60/109 (55%), Gaps = 8/109 (7%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKE--EENRRLEEKRRAE--EAQRQL-EQERRERELREA 217
++ +E KR+ + + E+E E+ RR +E+R E E +RQL EQERR + R
Sbjct: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
Query: 218 ARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKER 266
A RE + +E+ + + Q+E+ + + E++ + R++ +++E+
Sbjct: 729 AERELQEREKALRLQKE---QLQRELEEKKKKEEQQRLAERQLQEEQEK 774
Score = 40.0 bits (92), Expect = 0.004
Identities = 34/127 (26%), Positives = 61/127 (48%), Gaps = 16/127 (12%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERE------------LREAARREQRYQEQGG 229
K E+ E R+ EE+ R +Q E+ERR +E LR+AA ++ +++
Sbjct: 627 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 686
Query: 230 EASPQRTWEQ---QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPG-KLRSPF 285
E Q EQ +QE + R EQE + +E +++ER + + + +L+
Sbjct: 687 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ 746
Query: 286 LQKQLTQ 292
LQ++L +
Sbjct: 747 LQRELEE 753
Score = 39.7 bits (91), Expect = 0.005
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 17/176 (9%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARR----EQRYQEQGGEASPQRTW 237
K EK +E R EEK + + A +++E+ R+ E ARR +Q +E+ + Q+
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664
Query: 238 EQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF 297
E++QE + + + A + +++ER + + R ++QL + E
Sbjct: 665 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQ--ERQLAEQERRR 722
Query: 298 GREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQ 353
+E A +L E A ++ ++E + E E++ EQ L ++Q
Sbjct: 723 EQERLQA----ERELQEREKA-------LRLQKEQLQRELEEKKKKEEQQRLAERQ 767
Score = 37.0 bits (84), Expect = 0.035
Identities = 44/197 (22%), Positives = 85/197 (43%), Gaps = 36/197 (18%)
Query: 185 KEEENRRLEEKRRAEEAQ------------RQLEQE--RRERELREAARREQRYQEQGGE 230
KE+E +RLE RR EEA+ R+LE+ +RE LR+ + +R ++ E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 231 ASPQ----------RTWEQQQEVVSRNRNEQESAVHPREIF----KQKERAMSTTSISSP 276
Q +T + ++E ++ + ++++A E KQ+E A +
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
Query: 277 QPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE 336
+ + LQK+ + + + AA ++ A+ +E + E+E +E
Sbjct: 651 EEERRHQELLQKKKEEEQERLRK---AAEAKRLAEQREQERREQE-----RREQERREQE 702
Query: 337 PPEQETFYEQPPLVQQQ 353
EQE ++ L +Q+
Sbjct: 703 RREQERREQERQLAEQE 719
Score = 35.0 bits (79), Expect = 0.13
Identities = 18/40 (45%), Positives = 27/40 (67%), Gaps = 3/40 (7%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLE---QERRERELREAA 218
+ +KE+ R LEEK++ EE QR E QE +E++ +EAA
Sbjct: 741 RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780
>gi|47087157 nebulette non-muscle isoform [Homo sapiens]
Length = 270
Score = 53.9 bits (128), Expect = 3e-07
Identities = 47/200 (23%), Positives = 82/200 (41%), Gaps = 21/200 (10%)
Query: 246 RNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAI 305
+ ++E +S V + F++ + + +P+ +L+ Q+Q++ + H E
Sbjct: 75 KQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRT--QEQISNVKYHEDFEKTKGR 132
Query: 306 S-RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHI 364
P D P E + A + V+ E + +P ++ + H
Sbjct: 133 GFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMD---RRPGIIVAPVLPGAYQQSHS 189
Query: 365 QGQGLSGQGLCA--------------RALYDYQAADDTEISFDPENLITGIEVIDEGWWR 410
QG G Q + RA+YDY A D+ E+SF + I ++ ID+GW
Sbjct: 190 QGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMY 249
Query: 411 G-YGPDGHFGMFPANYVELI 429
G G GM PANY+E +
Sbjct: 250 GTVQRTGRTGMLPANYIEFV 269
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 53.9 bits (128), Expect = 3e-07
Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 9/166 (5%)
Query: 184 EKEEENRRLEEKRRAE-EAQRQLEQERRERE------LREAARREQRYQEQGGEASPQRT 236
+++E+ RRLEE++R E EA+RQ E+E+R RE L E RR + +E+ +R
Sbjct: 401 QQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 237 WEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 296
E++QE + R E++ + + +E+AM P P + P +Q +
Sbjct: 461 VEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSF 520
Query: 297 FGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQET 342
EP A AD E P +T V + ++ + +Q +
Sbjct: 521 HAPEPKAHYE--PADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNS 564
Score = 46.6 bits (109), Expect = 4e-05
Identities = 38/140 (27%), Positives = 60/140 (42%), Gaps = 5/140 (3%)
Query: 187 EENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSR 246
E +R+E+++ E+ +R EQ+RRERE R REQR +EQ + + +++E R
Sbjct: 394 ERQKRIEQQK--EQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Query: 247 NRNEQESAVHPRE---IFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAA 303
R E+E RE I +Q E + Q + ++ L H + P
Sbjct: 452 RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPP 511
Query: 304 AISRPRADLPAEEPAPSTPP 323
R + A EP P
Sbjct: 512 QQERSKPSFHAPEPKAHYEP 531
Score = 34.3 bits (77), Expect = 0.22
Identities = 41/173 (23%), Positives = 67/173 (38%), Gaps = 24/173 (13%)
Query: 193 EEKRRAEEAQRQL---EQERRERE------LREAARREQRYQEQGGEASPQRTWE----Q 239
E K R+E +RQ EQ+ RE+E L E +R ++ +EQ Q+ E +
Sbjct: 362 ENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR 421
Query: 240 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFG- 298
QQE R R ++E ++KE + + + ++++QL + + H
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
Query: 299 ------REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYE 345
+E A + R P P P Q E PE + YE
Sbjct: 482 LQQQLLQEQAMLLHDHRRPHPQHSQQPPPP----QQERSKPSFHAPEPKAHYE 530
Score = 33.1 bits (74), Expect = 0.50
Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 18/164 (10%)
Query: 187 EENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSR 246
E R + R +E + + E RR++ L+E REQ ++ A Q+ EQQ+E +
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE---Q 405
Query: 247 NRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAIS 306
R +E RE +Q+ER Q K R L+++ + E
Sbjct: 406 RRRLEEQQRREREARRQQEREQRRRE----QEEKRRLEELERRRKEEE-----------E 450
Query: 307 RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLV 350
R RA+ Q EEE + E +Q+ EQ L+
Sbjct: 451 RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLL 494
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 53.1 bits (126), Expect = 5e-07
Identities = 24/55 (43%), Positives = 34/55 (61%), Gaps = 1/55 (1%)
Query: 375 CARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 429
C RALYD++ ++ E+ F ++IT IDE W+ G GH G FP NYVE++
Sbjct: 294 CCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGM-LHGHSGFFPINYVEIL 347
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 52.8 bits (125), Expect = 6e-07
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 377 RALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYVELI 429
RA+YDY A D+ E+SF + I ++ ID+GW G G GM PANY+E +
Sbjct: 960 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 52.8 bits (125), Expect = 6e-07
Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 7/127 (5%)
Query: 184 EKEEENRRLEEKRRAE-EAQRQLEQERRERE------LREAARREQRYQEQGGEASPQRT 236
+++E+ RRLEE++R E EA+RQ E+E+R RE L E RR + +E+ +R
Sbjct: 401 QQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 237 WEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 296
E++QE + R E++ + + +E+AM P P + P +Q +
Sbjct: 461 VEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSF 520
Query: 297 FGREPAA 303
EP A
Sbjct: 521 HAPEPKA 527
Score = 46.6 bits (109), Expect = 4e-05
Identities = 38/140 (27%), Positives = 60/140 (42%), Gaps = 5/140 (3%)
Query: 187 EENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSR 246
E +R+E+++ E+ +R EQ+RRERE R REQR +EQ + + +++E R
Sbjct: 394 ERQKRIEQQK--EQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Query: 247 NRNEQESAVHPRE---IFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAA 303
R E+E RE I +Q E + Q + ++ L H + P
Sbjct: 452 RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPP 511
Query: 304 AISRPRADLPAEEPAPSTPP 323
R + A EP P
Sbjct: 512 QQERSKPSFHAPEPKAHYEP 531
Score = 34.3 bits (77), Expect = 0.22
Identities = 41/173 (23%), Positives = 67/173 (38%), Gaps = 24/173 (13%)
Query: 193 EEKRRAEEAQRQL---EQERRERE------LREAARREQRYQEQGGEASPQRTWE----Q 239
E K R+E +RQ EQ+ RE+E L E +R ++ +EQ Q+ E +
Sbjct: 362 ENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR 421
Query: 240 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFG- 298
QQE R R ++E ++KE + + + ++++QL + + H
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
Query: 299 ------REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYE 345
+E A + R P P P Q E PE + YE
Sbjct: 482 LQQQLLQEQAMLLHDHRRPHPQHSQQPPPP----QQERSKPSFHAPEPKAHYE 530
Score = 33.1 bits (74), Expect = 0.50
Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 18/164 (10%)
Query: 187 EENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSR 246
E R + R +E + + E RR++ L+E REQ ++ A Q+ EQQ+E +
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE---Q 405
Query: 247 NRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAIS 306
R +E RE +Q+ER Q K R L+++ + E
Sbjct: 406 RRRLEEQQRREREARRQQEREQRRRE----QEEKRRLEELERRRKEEE-----------E 450
Query: 307 RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLV 350
R RA+ Q EEE + E +Q+ EQ L+
Sbjct: 451 RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLL 494
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 52.8 bits (125), Expect = 6e-07
Identities = 27/62 (43%), Positives = 39/62 (62%), Gaps = 1/62 (1%)
Query: 370 SGQGLCARALYDYQAADDTEISFDPENLITGIEVIDE-GWWRGYGPDGHFGMFPANYVEL 428
SG + RALYDY+ + E+SF + +T +E DE GW +G +G G++PANYVE
Sbjct: 425 SGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEA 484
Query: 429 IE 430
I+
Sbjct: 485 IQ 486
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 52.0 bits (123), Expect = 1e-06
Identities = 46/198 (23%), Positives = 91/198 (45%), Gaps = 14/198 (7%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEK----EEENRRLEEKRRAEEAQRQLEQERRERELREAA 218
+K + E R +D W + EK EE+ R EEK +E + + + E+ + + E
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 219 RREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQP 278
R+E++ +EQ E ++ W Q++++ ++ +E E+++Q+E+ + Q
Sbjct: 392 RQEEKIREQ-EEKRQEKMWRQEKKMREQDEKIRE---QEEEMWRQEEKIRELEEMMQDQE 447
Query: 279 GKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPP 338
KLR ++ Q E +E I R + +E L++ EE+ +E
Sbjct: 448 EKLRE---VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504
Query: 339 ---EQETFYEQPPLVQQQ 353
++E +EQ +Q+Q
Sbjct: 505 MWRQEEKMWEQEEKMQEQ 522
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/146 (25%), Positives = 68/146 (46%), Gaps = 12/146 (8%)
Query: 144 KESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEK----EEENRRLEEKRRAE 199
+E R Q+ Q + +K E R ++ W + EK EE + EEK R
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453
Query: 200 EAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRN-EQESAVHPR 258
E + Q E+E+ + + + R+E++ QEQ ++TW Q++ + + EQE + +
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQEQ-----EEKTWRQEKLLKQEEKIWEQEEKMWRQ 508
Query: 259 E--IFKQKERAMSTTSISSPQPGKLR 282
E +++Q+E+ Q K+R
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMR 534
Score = 36.2 bits (82), Expect = 0.059
Identities = 43/183 (23%), Positives = 82/183 (44%), Gaps = 14/183 (7%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAA-RREQRYQEQGGEASPQ--RTWEQQ 240
+++EE +E++ E+ ++ EQE + RE E R+E++ EQ + Q + W Q+
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQE 352
Query: 241 QEVVSRNR--NEQESAVHPRE--IFKQKERAMSTTSISSPQPGKLR--SPFLQKQLTQPE 294
+++ + EQE + +E I +Q E+ Q K+R Q+++ + E
Sbjct: 353 EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412
Query: 295 THFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYE----EPPEQETFYEQPPLV 350
RE I ++ +E ++Q +EE + E E+E EQ +
Sbjct: 413 KKM-REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 351 QQQ 353
Q+Q
Sbjct: 472 QRQ 474
Score = 32.0 bits (71), Expect = 1.1
Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 12/111 (10%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEV 243
E+EE+ R EEK +E + Q ++E+ +R+ E++ +EQ R W+Q++++
Sbjct: 500 EQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ-------EEKMREQ-----EVRLWQQEEKM 547
Query: 244 VSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPE 294
+ QE ++ ++ E S Q +P LQ +L E
Sbjct: 548 QEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQE 598
Score = 31.6 bits (70), Expect = 1.5
Identities = 23/113 (20%), Positives = 56/113 (49%), Gaps = 9/113 (7%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEK-EEENRRLEEKRRAEEAQRQLEQERRERELRE--AAR 219
+K + E+ + ++ EK +EE +++E+ + Q + QE+ E+ R+ +
Sbjct: 434 EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493
Query: 220 REQRYQEQGGE--ASPQRTWEQQQEVVSRNRNEQESAVHPRE----IFKQKER 266
+E++ EQ + ++ WEQ++++ + Q RE +++Q+E+
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK 546
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 52.0 bits (123), Expect = 1e-06
Identities = 46/198 (23%), Positives = 91/198 (45%), Gaps = 14/198 (7%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEK----EEENRRLEEKRRAEEAQRQLEQERRERELREAA 218
+K + E R +D W + EK EE+ R EEK +E + + + E+ + + E
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 219 RREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQP 278
R+E++ +EQ E ++ W Q++++ ++ +E E+++Q+E+ + Q
Sbjct: 392 RQEEKIREQ-EEKRQEKMWRQEKKMREQDEKIRE---QEEEMWRQEEKIRELEEMMQDQE 447
Query: 279 GKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPP 338
KLR ++ Q E +E I R + +E L++ EE+ +E
Sbjct: 448 EKLRE---VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504
Query: 339 ---EQETFYEQPPLVQQQ 353
++E +EQ +Q+Q
Sbjct: 505 MWRQEEKMWEQEEKMQEQ 522
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/146 (25%), Positives = 68/146 (46%), Gaps = 12/146 (8%)
Query: 144 KESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEK----EEENRRLEEKRRAE 199
+E R Q+ Q + +K E R ++ W + EK EE + EEK R
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453
Query: 200 EAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRN-EQESAVHPR 258
E + Q E+E+ + + + R+E++ QEQ ++TW Q++ + + EQE + +
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQEQ-----EEKTWRQEKLLKQEEKIWEQEEKMWRQ 508
Query: 259 E--IFKQKERAMSTTSISSPQPGKLR 282
E +++Q+E+ Q K+R
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMR 534
Score = 36.2 bits (82), Expect = 0.059
Identities = 43/183 (23%), Positives = 82/183 (44%), Gaps = 14/183 (7%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAA-RREQRYQEQGGEASPQ--RTWEQQ 240
+++EE +E++ E+ ++ EQE + RE E R+E++ EQ + Q + W Q+
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQE 352
Query: 241 QEVVSRNR--NEQESAVHPRE--IFKQKERAMSTTSISSPQPGKLR--SPFLQKQLTQPE 294
+++ + EQE + +E I +Q E+ Q K+R Q+++ + E
Sbjct: 353 EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412
Query: 295 THFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYE----EPPEQETFYEQPPLV 350
RE I ++ +E ++Q +EE + E E+E EQ +
Sbjct: 413 KKM-REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 351 QQQ 353
Q+Q
Sbjct: 472 QRQ 474
Score = 32.0 bits (71), Expect = 1.1
Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 12/111 (10%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEV 243
E+EE+ R EEK +E + Q ++E+ +R+ E++ +EQ R W+Q++++
Sbjct: 500 EQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ-------EEKMREQ-----EVRLWQQEEKM 547
Query: 244 VSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPE 294
+ QE ++ ++ E S Q +P LQ +L E
Sbjct: 548 QEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQE 598
Score = 31.6 bits (70), Expect = 1.5
Identities = 23/113 (20%), Positives = 56/113 (49%), Gaps = 9/113 (7%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEK-EEENRRLEEKRRAEEAQRQLEQERRERELRE--AAR 219
+K + E+ + ++ EK +EE +++E+ + Q + QE+ E+ R+ +
Sbjct: 434 EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493
Query: 220 REQRYQEQGGE--ASPQRTWEQQQEVVSRNRNEQESAVHPRE----IFKQKER 266
+E++ EQ + ++ WEQ++++ + Q RE +++Q+E+
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK 546
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 52.0 bits (123), Expect = 1e-06
Identities = 22/55 (40%), Positives = 36/55 (65%), Gaps = 1/55 (1%)
Query: 372 QGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYV 426
+G RA+YD++AA+D E++F +IT ++ D WW+G G G+FP+N+V
Sbjct: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQG-IGLFPSNFV 264
>gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo
sapiens]
Length = 525
Score = 52.0 bits (123), Expect = 1e-06
Identities = 47/200 (23%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQ 239
W KA +E++ + +E + + + Q+E R +E E RE + Q Q + WE+
Sbjct: 148 WKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEEAEKPEREAKEQHQ-------KLWEE 200
Query: 240 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISS-PQ-----PGKLRSPFLQKQL--- 290
Q + ++ +A +E+ + +S T + + P+ G L Q L
Sbjct: 201 QLAAAKAQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGDGALSEAEAQALLSGD 260
Query: 291 --TQPETHFGREPAAAISRPRAD-LPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQP 347
T + + R AA + R++ LP + PAPS P EE+ P +E E+
Sbjct: 261 TQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKEEQPPVPSSPTEEEEEEEE 320
Query: 348 PLVQQQGAGSEHIDHHIQGQ 367
++ E D +QG+
Sbjct: 321 EEEEEAEEEEEEEDSEVQGE 340
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 52.0 bits (123), Expect = 1e-06
Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 15/169 (8%)
Query: 184 EKEEENRRLEEKRRAE-EAQRQLEQERRERE------LREAARREQRYQEQGGEASPQRT 236
+++E+ RRLEE++R E EA+RQ E+E+R RE L E RR + +E+ +R
Sbjct: 401 QQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR 460
Query: 237 WEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 296
E++QE + R E++ + + +E+AM ++ LQ+QL Q +
Sbjct: 461 VEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQ-- 518
Query: 297 FGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYE 345
A + + D P S P Q E PE + YE
Sbjct: 519 ------AYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYE 561
Score = 34.7 bits (78), Expect = 0.17
Identities = 46/186 (24%), Positives = 75/186 (40%), Gaps = 21/186 (11%)
Query: 187 EENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSR 246
E R + R +E + + E RR++ L+E REQ ++ A Q+ EQQ+E +
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE---Q 405
Query: 247 NRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAIS 306
R +E RE +Q+ER Q K R L+++ + E
Sbjct: 406 RRRLEEQQRREREARRQQEREQRRRE----QEEKRRLEELERRRKEEE-----------E 450
Query: 307 RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQG 366
R RA+ Q EEE + E +Q+ EQ L++ + ++ H Q
Sbjct: 451 RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRW---REMEEHRQA 507
Query: 367 QGLSGQ 372
+ L Q
Sbjct: 508 ERLQRQ 513
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 51.6 bits (122), Expect = 1e-06
Identities = 58/221 (26%), Positives = 86/221 (38%), Gaps = 23/221 (10%)
Query: 216 EAARREQRYQEQG----GEASPQRTW-EQQQEVVSRNRNEQESAVHPREIFKQKERAMST 270
E R E Q +G S W E+ Q + + E +H + K +
Sbjct: 45 ETVRGEAPSQPRGIPHRSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRK 104
Query: 271 TSISSPQPGKL--RSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQA 328
T I+SP+ L RS L + H G P +P + A T C +
Sbjct: 105 TIITSPESLNLPRRSHPLSQSAPTGLNHMGWPEHT----PGTAMP--DGALDTAVCADEV 158
Query: 329 -EEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADD 387
EE +Y++ Y P G G E + I G +CA AL+D+ DD
Sbjct: 159 GSEEDLYDDLHSSSHHYSHP------GGGGEQLA--INELISDGSVVCAEALWDHVTMDD 210
Query: 388 TEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 428
E+ F ++I ++ + WW G DG G FPA++V L
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGE-GWFPASFVRL 250
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 51.6 bits (122), Expect = 1e-06
Identities = 58/221 (26%), Positives = 86/221 (38%), Gaps = 23/221 (10%)
Query: 216 EAARREQRYQEQG----GEASPQRTW-EQQQEVVSRNRNEQESAVHPREIFKQKERAMST 270
E R E Q +G S W E+ Q + + E +H + K +
Sbjct: 45 ETVRGEAPSQPRGIPHRSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRK 104
Query: 271 TSISSPQPGKL--RSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQA 328
T I+SP+ L RS L + H G P +P + A T C +
Sbjct: 105 TIITSPESLNLPRRSHPLSQSAPTGLNHMGWPEHT----PGTAMP--DGALDTAVCADEV 158
Query: 329 -EEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADD 387
EE +Y++ Y P G G E + I G +CA AL+D+ DD
Sbjct: 159 GSEEDLYDDLHSSSHHYSHP------GGGGEQLA--INELISDGSVVCAEALWDHVTMDD 210
Query: 388 TEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 428
E+ F ++I ++ + WW G DG G FPA++V L
Sbjct: 211 QELGFKAGDVIEVMDATNREWWWGRVADGE-GWFPASFVRL 250
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 50.8 bits (120), Expect = 2e-06
Identities = 26/59 (44%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 372 QGLCARALYDYQAADDTEISFDPENLITGIEVIDE-GWWRGYGPDGHFGMFPANYVELI 429
+G+ RALYDY + E+SF + +T + DE GW RG G G++PANYVE I
Sbjct: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,185,476
Number of Sequences: 37866
Number of extensions: 1048297
Number of successful extensions: 17073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 484
Number of HSP's successfully gapped in prelim test: 761
Number of HSP's that attempted gapping in prelim test: 6355
Number of HSP's gapped (non-prelim): 5271
length of query: 430
length of database: 18,247,518
effective HSP length: 105
effective length of query: 325
effective length of database: 14,271,588
effective search space: 4638266100
effective search space used: 4638266100
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.