BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|61743944 abl-interactor 1 isoform b [Homo sapiens] (481 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|61743944 abl-interactor 1 isoform b [Homo sapiens] 988 0.0 gi|61743942 abl-interactor 1 isoform a [Homo sapiens] 973 0.0 gi|61743948 abl-interactor 1 isoform d [Homo sapiens] 971 0.0 gi|61743946 abl-interactor 1 isoform c [Homo sapiens] 905 0.0 gi|109689723 abl interactor 2 [Homo sapiens] 704 0.0 gi|7705981 NESH protein isoform 1 [Homo sapiens] 271 1e-72 gi|206597502 NESH protein isoform 2 [Homo sapiens] 261 8e-70 gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 65 1e-10 gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 65 1e-10 gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 65 1e-10 gi|55741677 SET domain containing 1A [Homo sapiens] 63 7e-10 gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] 62 9e-10 gi|46094081 development and differentiation enhancing factor 1 [... 62 2e-09 gi|116284392 mucin 2 precursor [Homo sapiens] 61 2e-09 gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 61 3e-09 gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 61 3e-09 gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 60 4e-09 gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 60 4e-09 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 60 4e-09 gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 60 6e-09 gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 60 6e-09 gi|55956916 myosin IE [Homo sapiens] 59 7e-09 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 59 1e-08 gi|150417989 cyclin K isoform 1 [Homo sapiens] 59 1e-08 gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 58 2e-08 gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 58 2e-08 gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 58 2e-08 gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 58 2e-08 gi|203098098 shroom family member 3 protein [Homo sapiens] 58 2e-08 gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 58 2e-08 >gi|61743944 abl-interactor 1 isoform b [Homo sapiens] Length = 481 Score = 988 bits (2554), Expect = 0.0 Identities = 481/481 (100%), Positives = 481/481 (100%) Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS Sbjct: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS Sbjct: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300 Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 360 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE Sbjct: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 360 Query: 361 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 420 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY Sbjct: 361 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 420 Query: 421 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 480 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT Sbjct: 421 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 480 Query: 481 D 481 D Sbjct: 481 D 481 >gi|61743942 abl-interactor 1 isoform a [Homo sapiens] Length = 508 Score = 973 bits (2516), Expect = 0.0 Identities = 481/508 (94%), Positives = 481/508 (94%), Gaps = 27/508 (5%) Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS Sbjct: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP--------------------------- 273 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP Sbjct: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVI 300 Query: 274 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI 333 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI Sbjct: 301 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI 360 Query: 334 SIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD 393 SIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD Sbjct: 361 SIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD 420 Query: 394 YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND 453 YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND Sbjct: 421 YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND 480 Query: 454 DGWYEGVCNRVTGLFPGNYVESIMHYTD 481 DGWYEGVCNRVTGLFPGNYVESIMHYTD Sbjct: 481 DGWYEGVCNRVTGLFPGNYVESIMHYTD 508 >gi|61743948 abl-interactor 1 isoform d [Homo sapiens] Length = 476 Score = 971 bits (2509), Expect = 0.0 Identities = 476/481 (98%), Positives = 476/481 (98%), Gaps = 5/481 (1%) Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVK HGNNQPARTGTLSRTNPPTQK Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVK-----HGNNQPARTGTLSRTNPPTQK 175 Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS Sbjct: 176 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 235 Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS Sbjct: 236 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 295 Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 360 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE Sbjct: 296 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 355 Query: 361 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 420 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY Sbjct: 356 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 415 Query: 421 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 480 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT Sbjct: 416 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 475 Query: 481 D 481 D Sbjct: 476 D 476 >gi|61743946 abl-interactor 1 isoform c [Homo sapiens] Length = 452 Score = 905 bits (2339), Expect = 0.0 Identities = 448/481 (93%), Positives = 450/481 (93%), Gaps = 29/481 (6%) Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS Sbjct: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS Sbjct: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300 Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 360 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI+ +P P Sbjct: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTP--------------------- 339 Query: 361 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 420 PPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY Sbjct: 340 --------PPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 391 Query: 421 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 480 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT Sbjct: 392 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 451 Query: 481 D 481 D Sbjct: 452 D 452 >gi|109689723 abl interactor 2 [Homo sapiens] Length = 475 Score = 704 bits (1816), Expect = 0.0 Identities = 358/491 (72%), Positives = 406/491 (82%), Gaps = 26/491 (5%) Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 MAELQMLLEEEIP G+RAL +SY NL RVADYCENNYIQ+ DK++ALEETKAYTTQSLAS Sbjct: 1 MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLAS 60 Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 VAY IN LANNVLQ+LDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR Sbjct: 61 VAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 THKIIAPAN+ERPVRYIRKPIDYT+LDD+GHGVK + Q + G L RT PPTQK Sbjct: 121 THKIIAPANLERPVRYIRKPIDYTILDDIGHGVK------VSTQNMKMGGLPRTTPPTQK 174 Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPAR--LGSQHSPGRTASLNQRPRT 238 PPSPPMSG+GTLGR++PY+TLEPV+PP VPNDY+ SP R SQ SP RTAS+NQR RT Sbjct: 175 PPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRT 234 Query: 239 H--SGSSGG------SGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQ 290 + SGSSGG S SRENSGS S+G+PIAVPTPSPP++ P P Q+ +M R Sbjct: 235 YSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPGHP-----VQFYSMNRP 289 Query: 291 ISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIP 350 SRH T S YRR PS+T+Q S Q +NGGP YSQN +S+APPPP + Q+TPQ+P Sbjct: 290 ASRHTPPTIG-GSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSLAPPPPSILQVTPQLP 348 Query: 351 LTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYAD 410 L GFVARVQENI+D+ PPPPPP + P+FD+SPPPPPPP DYE+EEAAVV+Y+DPYA+ Sbjct: 349 LMGFVARVQENISDT---PPPPPPVEEPVFDESPPPPPPPE-DYEEEEAAVVEYSDPYAE 404 Query: 411 GDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPG 470 DP WAP++Y+EKVVAIYDYTKDK+DELSF EGAIIYVIKKNDDGWYEGV N VTGLFPG Sbjct: 405 EDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPG 464 Query: 471 NYVESIMHYTD 481 NYVESIMHY++ Sbjct: 465 NYVESIMHYSE 475 >gi|7705981 NESH protein isoform 1 [Homo sapiens] Length = 366 Score = 271 bits (692), Expect = 1e-72 Identities = 185/474 (39%), Positives = 244/474 (51%), Gaps = 111/474 (23%) Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 MAELQ L E EIP+G+ AL ++ L RVADYCE+NY+QATDKRKALEET A+TTQ+LAS Sbjct: 1 MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALAS 60 Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 VAYQ+ LA + L++LD+Q + LR++E+ ++ + Q V++H EKVARREIG L T + Sbjct: 61 VAYQVGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPP 120 Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 K+IAP N+ Y R+P+++ LDD+GHG+K L + Q +RTGTLSR + K Sbjct: 121 GQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDL-----STQLSRTGTLSR---KSIK 172 Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 P+ P S TLGR P + EPV P VP+ RL + S AS + Sbjct: 173 APATPAS--ATLGR--PPRIPEPVHLPVVPD------GRLSAASSASSLAS--------A 214 Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300 GS+ G G PTP G AAP + P Sbjct: 215 GSAEGVG--------------GAPTPK----GQAAPPAPP-------------------L 237 Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 360 SS P+ F P + ++PPPP ++PL Sbjct: 238 PSSLDPPPPPAAVEVFQRPPTLE----------ELSPPPP-----DEELPL--------- 273 Query: 361 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 420 P PPPPP D D+ PPPPP + +P+W P +Y Sbjct: 274 -----PLDLPPPPPLD---GDELGLPPPPP----------------GFGPDEPSWVPASY 309 Query: 421 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474 +EKVV +Y YT KD+ELSF EG +I V ++ DGW EGV + TG FPGNYVE Sbjct: 310 LEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVE 363 >gi|206597502 NESH protein isoform 2 [Homo sapiens] Length = 360 Score = 261 bits (668), Expect = 8e-70 Identities = 184/474 (38%), Positives = 241/474 (50%), Gaps = 117/474 (24%) Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60 MAELQ L E EIP+G+ AL ++ L RVADYCE+NY+QATDKRKALEET A+TTQ+LAS Sbjct: 1 MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALAS 60 Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120 VAYQ+ LA + L++LD+Q + LR++E ++ V++H EKVARREIG L T + Sbjct: 61 VAYQVGNLAGHTLRMLDLQGAALRQVE------ARMVNMHMEKVARREIGTLATVQRLPP 114 Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180 K+IAP N+ Y R+P+++ LDD+GHG+K L + Q +RTGTLSR + K Sbjct: 115 GQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDL-----STQLSRTGTLSR---KSIK 166 Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240 P+ P S TLGR P + EPV P VP+ RL + S AS + Sbjct: 167 APATPAS--ATLGR--PPRIPEPVHLPVVPD------GRLSAASSASSLAS--------A 208 Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300 GS+ G G PTP G AAP + P Sbjct: 209 GSAEGVG--------------GAPTPK----GQAAPPAPP-------------------L 231 Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 360 SS P+ F P + ++PPPP ++PL Sbjct: 232 PSSLDPPPPPAAVEVFQRPPTLE----------ELSPPPP-----DEELPL--------- 267 Query: 361 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 420 P PPPPP D D+ PPPPP + +P+W P +Y Sbjct: 268 -----PLDLPPPPPLD---GDELGLPPPPP----------------GFGPDEPSWVPASY 303 Query: 421 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474 +EKVV +Y YT KD+ELSF EG +I V ++ DGW EGV + TG FPGNYVE Sbjct: 304 LEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVE 357 >gi|194294523 intersectin 2 isoform 3 [Homo sapiens] Length = 1670 Score = 65.5 bits (158), Expect = 1e-10 Identities = 30/62 (48%), Positives = 44/62 (70%), Gaps = 3/62 (4%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 472 PA+ P + +V+A+YDY + +DELSF +G +I V+ K+D W++G N VTGLFP NY Sbjct: 1097 PAFHP---VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNY 1153 Query: 473 VE 474 V+ Sbjct: 1154 VK 1155 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 6/87 (6%) Query: 388 PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIY 447 P V E+ EA N P A + E+ +A+Y Y+ + +L+F EG I Sbjct: 928 PGSEVKREEPEALYAAVNKK-----PTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL 982 Query: 448 VIKKNDDGWYEGVCNRVTGLFPGNYVE 474 V +K D W+ G +G+FP NYV+ Sbjct: 983 VTQK-DGEWWTGSIGDRSGIFPSNYVK 1008 Score = 36.6 bits (83), Expect = 0.052 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 2/53 (3%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKK--NDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y + DE+SF G II V +K + GW G G FP NYVE + Sbjct: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 789 Score = 35.0 bits (79), Expect = 0.15 Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 5/50 (10%) Query: 430 YTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNYVE 474 Y ++LS G +I ++KKN GW++G R G FP ++V+ Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1086 Score = 33.9 bits (76), Expect = 0.34 Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%) Query: 423 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 K A+ +T KD+ L+F + II V+++ ++ W+ G + G FP +YV+ I Sbjct: 875 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF-GEVHGGRGWFPKSYVKII 927 >gi|194294521 intersectin 2 isoform 1 [Homo sapiens] Length = 1697 Score = 65.5 bits (158), Expect = 1e-10 Identities = 30/62 (48%), Positives = 44/62 (70%), Gaps = 3/62 (4%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 472 PA+ P + +V+A+YDY + +DELSF +G +I V+ K+D W++G N VTGLFP NY Sbjct: 1124 PAFHP---VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNY 1180 Query: 473 VE 474 V+ Sbjct: 1181 VK 1182 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 6/87 (6%) Query: 388 PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIY 447 P V E+ EA N P A + E+ +A+Y Y+ + +L+F EG I Sbjct: 955 PGSEVKREEPEALYAAVNKK-----PTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL 1009 Query: 448 VIKKNDDGWYEGVCNRVTGLFPGNYVE 474 V +K D W+ G +G+FP NYV+ Sbjct: 1010 VTQK-DGEWWTGSIGDRSGIFPSNYVK 1035 Score = 36.6 bits (83), Expect = 0.052 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 2/53 (3%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKK--NDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y + DE+SF G II V +K + GW G G FP NYVE + Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 816 Score = 35.0 bits (79), Expect = 0.15 Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 5/50 (10%) Query: 430 YTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNYVE 474 Y ++LS G +I ++KKN GW++G R G FP ++V+ Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1113 Score = 33.9 bits (76), Expect = 0.34 Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%) Query: 423 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 K A+ +T KD+ L+F + II V+++ ++ W+ G + G FP +YV+ I Sbjct: 902 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF-GEVHGGRGWFPKSYVKII 954 >gi|194294525 intersectin 2 isoform 2 [Homo sapiens] Length = 1249 Score = 65.5 bits (158), Expect = 1e-10 Identities = 30/62 (48%), Positives = 44/62 (70%), Gaps = 3/62 (4%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 472 PA+ P + +V+A+YDY + +DELSF +G +I V+ K+D W++G N VTGLFP NY Sbjct: 1124 PAFHP---VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNY 1180 Query: 473 VE 474 V+ Sbjct: 1181 VK 1182 Score = 43.1 bits (100), Expect = 6e-04 Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 6/87 (6%) Query: 388 PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIY 447 P V E+ EA N P A + E+ +A+Y Y+ + +L+F EG I Sbjct: 955 PGSEVKREEPEALYAAVNKK-----PTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL 1009 Query: 448 VIKKNDDGWYEGVCNRVTGLFPGNYVE 474 V +K D W+ G +G+FP NYV+ Sbjct: 1010 VTQK-DGEWWTGSIGDRSGIFPSNYVK 1035 Score = 36.6 bits (83), Expect = 0.052 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 2/53 (3%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKK--NDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y + DE+SF G II V +K + GW G G FP NYVE + Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 816 Score = 35.0 bits (79), Expect = 0.15 Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 5/50 (10%) Query: 430 YTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNYVE 474 Y ++LS G +I ++KKN GW++G R G FP ++V+ Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1113 Score = 33.9 bits (76), Expect = 0.34 Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%) Query: 423 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 K A+ +T KD+ L+F + II V+++ ++ W+ G + G FP +YV+ I Sbjct: 902 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF-GEVHGGRGWFPKSYVKII 954 >gi|55741677 SET domain containing 1A [Homo sapiens] Length = 1707 Score = 62.8 bits (151), Expect = 7e-10 Identities = 70/271 (25%), Positives = 87/271 (32%), Gaps = 67/271 (24%) Query: 164 QPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGS- 222 +P+R P ++ PP P G G P E V+ P SPAR GS Sbjct: 416 EPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRP----ASPARSGSP 471 Query: 223 ------------QHSP--GRTASLNQRPRTHSGSSGGSGSRENSGSSSI--GIPIAVPTP 266 QHS R L + R+ E SS + P Sbjct: 472 APETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVP 531 Query: 267 SPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGP 326 S GP P AP + + T S G R +P Q A P +G Sbjct: 532 SGSGHGPCTPPPAPANFEDV---------APTGSGEPGATRESPKANGQNQASPCSSGDD 582 Query: 327 L-YSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPP----------- 374 + S + +PPP P P P P P PPPPPPP Sbjct: 583 MEISDDDRGGSPPPAPTPPQQPPPP---------------PPPPPPPPPYLASLPLGYPP 627 Query: 375 ----------DDIPMFDDSPPPPPPPPVDYE 395 D P + PPPPPPPP Y+ Sbjct: 628 HQPAYLLPPRPDGPPPPEYPPPPPPPPHIYD 658 Score = 39.7 bits (91), Expect = 0.006 Identities = 63/240 (26%), Positives = 85/240 (35%), Gaps = 46/240 (19%) Query: 161 GNNQPARTGTL---SRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSP 217 GN P T SR + P+ P S +GT PY T P + + Y +S Sbjct: 238 GNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGT-----PY-TSRGSTPYSQDSAYSSS- 290 Query: 218 ARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPG 277 T S + +PR S + SR + +SS + T T A Sbjct: 291 -----------TTSTSFKPRRSENSYQDAFSRRHFSASSASTTAS--TAIAATTAATASS 337 Query: 278 SAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAP 337 SA S +S +S++SS+SS +R S A + A S N Sbjct: 338 SASSSS-------LSSSSSSSSSSSSSQFR---SSDANYPAYYE-------SWNRYQRHT 380 Query: 338 PPPPMPQLTPQIPLTGFVARVQENIADSPT---PPPPPPPDDI---PMFDDSPPPPPPPP 391 PP + P F E S T PP P P D P ++PPP PP P Sbjct: 381 SYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEP 440 Score = 37.0 bits (84), Expect = 0.040 Identities = 34/127 (26%), Positives = 51/127 (40%), Gaps = 12/127 (9%) Query: 281 GSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPP 340 G T + S +S++SS+SS + S +++ S++ + S S PPP Sbjct: 1025 GENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSAS--PPPR 1082 Query: 341 PMPQLTP---QIPLTGFVARV-------QENIADSPTPPPPPPPDDIPMFDDSPPPPPPP 390 +P TP ++P+ VA QE P P P P+ PP PP Sbjct: 1083 EVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPA 1142 Query: 391 PVDYEDE 397 P DE Sbjct: 1143 PAPRPDE 1149 Score = 34.3 bits (77), Expect = 0.26 Identities = 47/176 (26%), Positives = 59/176 (33%), Gaps = 33/176 (18%) Query: 225 SPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGI-----PIAVPTPSPPTIGPAAPGSA 279 S ++S + + S SS S S +S SSS P A+P+ SPP P A Sbjct: 1031 SDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPA 1090 Query: 280 PGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPP 339 P G TP + A P GP ++ S AP Sbjct: 1091 P--------------VEVPVPERVAGSPVTP--LPEQEASPARPAGP--TEESPPSAPLR 1132 Query: 340 PPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPD-----DIPMFDDSPPPPPPP 390 PP P P P A + SP P PPP + P P PPP Sbjct: 1133 PPEPPAGPPAP-----APRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPP 1183 >gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] Length = 639 Score = 62.4 bits (150), Expect = 9e-10 Identities = 63/228 (27%), Positives = 80/228 (35%), Gaps = 51/228 (22%) Query: 176 PPTQKPPSPPMS-GRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQ 234 PP +PP PPM+ G G + P PP + Y+ G T + Sbjct: 422 PPWMQPPPPPMNQGPHPPGHHGP--------PPM--DQYL------------GSTPVGSG 459 Query: 235 RPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSA---------PGSQYG 285 R H G G G P P PP GP P P S Sbjct: 460 VYRLHQGK--GMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSM 517 Query: 286 TMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQL 345 + + +TT++T+S G P Q +A G P N + PP P L Sbjct: 518 ASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPL 577 Query: 346 TPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD 393 P +P PPPPPPP M +PPPPPPPP+D Sbjct: 578 PP----------------GAPPPPPPPPPGSAGMMY-APPPPPPPPMD 608 Score = 48.9 bits (115), Expect = 1e-05 Identities = 58/245 (23%), Positives = 80/245 (32%), Gaps = 64/245 (26%) Query: 140 PID-YTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPY 198 P+D Y VG GV L G P G + PP P PP S G P+ Sbjct: 446 PMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPS-----GPLPPW 500 Query: 199 -KTLEPVKPPTVPNDYMTSPARLGSQH------SPGRTASLNQRPRTHSGSSGGSGSREN 251 + + PP P+ M S L Q + T S+ + + ++ G+ + Sbjct: 501 QQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQM 560 Query: 252 SGS-SSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTP 310 G+ + + +P V P PP P P PGS Sbjct: 561 QGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGS---------------------------- 592 Query: 311 SVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQ--IPLTGFVARVQENIADSPTP 368 G +Y APPPPP P + P + + G P P Sbjct: 593 -------------AGMMY-------APPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAP 632 Query: 369 PPPPP 373 PPPPP Sbjct: 633 PPPPP 637 Score = 43.9 bits (102), Expect = 3e-04 Identities = 40/140 (28%), Positives = 46/140 (32%), Gaps = 33/140 (23%) Query: 272 GPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQN 331 GP PG P S + H + G P P +N GP Sbjct: 386 GPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNG----PPPPWMQPPPPPMNQGP----- 436 Query: 332 SISIAPP----PPPMPQLTPQIPLTGFVARVQENIADSPTPP------PPPPPDDIPMFD 381 PP PPPM Q P+ V R+ + P PP PPPPP P Sbjct: 437 ----HPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPP 492 Query: 382 DSPP----------PPPPPP 391 S P PPPPPP Sbjct: 493 PSGPLPPWQQQQQQPPPPPP 512 Score = 40.4 bits (93), Expect = 0.004 Identities = 58/227 (25%), Positives = 70/227 (30%), Gaps = 42/227 (18%) Query: 165 PARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGS-Q 223 PA T S P PP S T P+ P + + P G Sbjct: 335 PATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGP 394 Query: 224 HS-PGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGS---A 279 HS P SL +G GG + N P P P P GP PG Sbjct: 395 HSFPHPLPSL-------TGGHGGHPMQHNPNGPPP--PWMQPPPPPMNQGPHPPGHHGPP 445 Query: 280 PGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPP 339 P QY T SG YR G + + + PPP Sbjct: 446 PMDQYLGST-----------PVGSGVYRLH-------------QGKGMMPPPPMGMMPPP 481 Query: 340 PPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPP 386 PP P P P +G + Q+ PPPPPP M +P P Sbjct: 482 PPPPSGQPPPPPSGPLPPWQQ----QQQQPPPPPPPSSSMASSTPLP 524 Score = 31.6 bits (70), Expect = 1.7 Identities = 39/140 (27%), Positives = 49/140 (35%), Gaps = 32/140 (22%) Query: 260 PIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQ 319 P P S P PAAP + P T Q + + S Y Sbjct: 335 PATTPLASAPR--PAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYH------GMHGGG 386 Query: 320 PHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPP---PPPPPDD 376 P GGP +S P P+P LT G ++ + P PP PPPPP Sbjct: 387 P---GGPGGGPHSF-----PHPLPSLTG-----GHGGHPMQHNPNGPPPPWMQPPPPP-- 431 Query: 377 IPMFDDSPPPPP---PPPVD 393 + P PP PPP+D Sbjct: 432 ---MNQGPHPPGHHGPPPMD 448 >gi|46094081 development and differentiation enhancing factor 1 [Homo sapiens] Length = 1129 Score = 61.6 bits (148), Expect = 2e-09 Identities = 95/359 (26%), Positives = 134/359 (37%), Gaps = 65/359 (18%) Query: 168 TGTLSRTNPPTQKPPSPPMS-GRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSP 226 T T S T+P T+ PP PP + G+G G P TL P+ T S R P Sbjct: 778 TSTDSPTSPTTEAPPLPPRNAGKGPTG---PPSTL-PLSTQTSSGSSTLSKKR-PPPPPP 832 Query: 227 G--RTASLNQRPRTHS---------GSSGGSGSRENSGSSSIGIPIAVPTPSPPT-IGPA 274 G RT S P H G+ GG S + + G+ T S T +GP Sbjct: 833 GHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPR 892 Query: 275 APGSAPGSQYGTMTRQISRHNSTT-------SSTSSGGYRRTPS-----VTAQFSAQPHV 322 P T +S +T SS + ++ P + + +P + Sbjct: 893 VLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQI 952 Query: 323 NG--------------GPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTP 368 G L + +S PP P M L P+ L +A+ Q Sbjct: 953 GDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTG----DVS 1008 Query: 369 PPPPPPDDIPMFDDSPPPPPPPPVDYED--EEAAVVQYND--PYADGDPAWAP------K 418 P P ++ + S P P V D ++ A ND P P P K Sbjct: 1009 PKAQQPSEVTL--KSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGK 1066 Query: 419 NYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWY----EGVCNRVTGLFPGNYV 473 N + +V IYD D DDEL+F+EG +I V + D W+ EG R G+FP ++V Sbjct: 1067 NKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPER-KGVFPVSFV 1124 Score = 32.3 bits (72), Expect = 0.98 Identities = 33/120 (27%), Positives = 40/120 (33%), Gaps = 25/120 (20%) Query: 272 GPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQN 331 G + P YG T QI ST S TS P PL +N Sbjct: 755 GFSTPRDKQRLSYGAFTNQIFVSTSTDSPTS-----------------PTTEAPPLPPRN 797 Query: 332 SISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPP 391 + P PP +PL+ + + S PPPPPP D P P P P Sbjct: 798 A-GKGPTGPPST-----LPLSTQTSSGSSTL--SKKRPPPPPPGHKRTLSDPPSPLPHGP 849 >gi|116284392 mucin 2 precursor [Homo sapiens] Length = 5179 Score = 61.2 bits (147), Expect = 2e-09 Identities = 61/225 (27%), Positives = 86/225 (38%), Gaps = 14/225 (6%) Query: 170 TLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRT 229 T + T PP PSPP + T +T TL P P+ P T+P + P T Sbjct: 1527 TTTTTTPPPTTTPSPPTTTPITPPTSTT--TLPPTTTPSPPPTTTTTPPPTTTPSPPTTT 1584 Query: 230 ASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTR 289 P T + ++ + + +++ P TPSPPT P P ++ + T T Sbjct: 1585 TP---SPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTP 1641 Query: 290 QISRHNSTT---SSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLT 346 +TT ++T S TPS + P P + I+ P PP T Sbjct: 1642 SPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTP---SSPITTTPSPPTTTMTT 1698 Query: 347 PQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPP 391 P P T + + S T P PPP M SP P PP Sbjct: 1699 PS-PTTTPSSPITTTTTPSSTTTPSPPPTT--MTTPSPTTTPSPP 1740 Score = 60.1 bits (144), Expect = 4e-09 Identities = 63/249 (25%), Positives = 91/249 (36%), Gaps = 31/249 (12%) Query: 170 TLSRTNPPTQKPPSPPMSGRGTLGRNT----PYKTLEPVKPPTVPNDYMTSPARLGSQHS 225 T + T PP PSPP++ T T P T P T P+ T+P+ + S Sbjct: 1426 TTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPS 1485 Query: 226 PGRTASLNQRPRT-------------HSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIG 272 P T + P T S ++ + + +++ P TPSPPT Sbjct: 1486 PPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTT 1545 Query: 273 PAAPGSAPGSQYGTMTRQISRHNSTT---SSTSSGGYRRTPSVTAQFSAQPHVNGGPLYS 329 P P ++ + T T +TT ++T S TPS + P P Sbjct: 1546 PITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPP 1605 Query: 330 QNSISIAPP--PPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPP 387 + + PP P P TP P T + + TP PPP P +P PP Sbjct: 1606 TTTTTTPPPTTTPSPPTTTPITPPTS-----TTTLPPTTTPSPPPTTTTTPPPTTTPSPP 1660 Query: 388 ----PPPPV 392 P PP+ Sbjct: 1661 TTTTPSPPI 1669 Score = 55.5 bits (132), Expect = 1e-07 Identities = 59/222 (26%), Positives = 78/222 (35%), Gaps = 28/222 (12%) Query: 170 TLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRT 229 T++ T PP PSPP T TP T P P T P TS L +P Sbjct: 1590 TITTTTPPPTTTPSPP-----TTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPP 1644 Query: 230 ASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAP-GSAPGSQYGTMT 288 + P + S + +++ PI T PPT P++P + P TMT Sbjct: 1645 PTTTTTPPPTTTPSPPT-------TTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMT 1697 Query: 289 RQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQ 348 + TT+ +S TPS T S P P P PP +T Sbjct: 1698 TP----SPTTTPSSPITTTTTPSSTTTPSPPPTTMTTP------SPTTTPSPPTTTMTTL 1747 Query: 349 IPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPP 390 P T + +P PP PP P +P P P Sbjct: 1748 PPTT-----TSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVP 1784 Score = 52.0 bits (123), Expect = 1e-06 Identities = 55/223 (24%), Positives = 74/223 (33%), Gaps = 40/223 (17%) Query: 171 LSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTA 230 ++ +PPT P PP T TL P P+ P T+P + SP T Sbjct: 1396 ITTPSPPTTTPSPPP----------TSTTTLPPTTTPSPPTTTTTTPPPTTTP-SPPITT 1444 Query: 231 SLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQ 290 + P T + S+ P TPSPPT P+ P + P Sbjct: 1445 TTTPPPTT----------TPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPP------- 1487 Query: 291 ISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIP 350 +TT++T +P T + P + S P P TP P Sbjct: 1488 -----TTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPP 1542 Query: 351 LTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPP---PPPP 390 T + PT P PPP +PPP P PP Sbjct: 1543 TTTPITPPTSTTTLPPTTTPSPPPTT----TTTPPPTTTPSPP 1581 Score = 40.8 bits (94), Expect = 0.003 Identities = 39/156 (25%), Positives = 61/156 (39%), Gaps = 9/156 (5%) Query: 165 PARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTV-PNDYMTSPARLGSQ 223 P T + T PPT P PP + TP T P P T P+ +T+ Sbjct: 1625 PITPPTSTTTLPPTTTPSPPPTT------TTTPPPTTTPSPPTTTTPSPPITTTTTPPPT 1678 Query: 224 HSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPP--TIGPAAPGSAPG 281 +P + P T + ++ + +S ++ P + TPSPP T+ +P + P Sbjct: 1679 TTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPS 1738 Query: 282 SQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFS 317 TMT S+ +T+ TP + FS Sbjct: 1739 PPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFS 1774 Score = 39.7 bits (91), Expect = 0.006 Identities = 59/250 (23%), Positives = 94/250 (37%), Gaps = 29/250 (11%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRNTPYKTLEPVKP---PTVPNDYMTSP 217 P TGT + T P T P+P +G T TP T V P PT T+P Sbjct: 4027 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQT-PTTTPITTTTTVTPTPTPTGTQTPTTTP 4085 Query: 218 ARLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPP 269 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 4086 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 4145 Query: 270 TIGPAAPGSAPGSQYGTMTRQIS----RHNSTTSSTSSGGYRRTPSVTAQFSAQP-HVNG 324 G P + P + T+T + + +TT T++ TP+ T + P H + Sbjct: 4146 --GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTST 4203 Query: 325 GPLYSQNSISIAPPPPPMPQL-----TPQIPLTGFVARVQENIADSPTPPPPPPPDDIPM 379 P+ ++ + S PP PQ +P T ++ + I + T PP P Sbjct: 4204 API-AELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTT 4262 Query: 380 FDDSPPPPPP 389 PPP Sbjct: 4263 SGGHTLSPPP 4272 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 2049 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2108 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 2109 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 2166 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 2167 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 2224 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 2225 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2279 Query: 390 PP 391 P Sbjct: 2280 TP 2281 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 2210 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2269 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 2270 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 2327 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 2328 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 2385 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 2386 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2440 Query: 390 PP 391 P Sbjct: 2441 TP 2442 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 2371 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2430 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 2431 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 2488 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 2489 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 2546 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 2547 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2601 Query: 390 PP 391 P Sbjct: 2602 TP 2603 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 2532 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2591 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 2592 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 2649 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 2650 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 2707 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 2708 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2762 Query: 390 PP 391 P Sbjct: 2763 TP 2764 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 2693 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2752 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 2753 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 2810 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 2811 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 2868 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 2869 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2923 Query: 390 PP 391 P Sbjct: 2924 TP 2925 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 2854 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2913 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 2914 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 2971 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 2972 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 3029 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 3030 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3084 Query: 390 PP 391 P Sbjct: 3085 TP 3086 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 3015 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3074 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 3075 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 3132 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 3133 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 3190 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 3191 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3245 Query: 390 PP 391 P Sbjct: 3246 TP 3247 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 3176 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3235 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 3236 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 3293 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 3294 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 3351 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 3352 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3406 Query: 390 PP 391 P Sbjct: 3407 TP 3408 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 3337 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3396 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 3397 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 3454 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 3455 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 3512 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 3513 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3567 Query: 390 PP 391 P Sbjct: 3568 TP 3569 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 3498 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3557 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 3558 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 3615 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 3616 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 3673 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 3674 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3728 Query: 390 PP 391 P Sbjct: 3729 TP 3730 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 3659 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3718 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 3719 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 3776 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 3777 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 3834 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 3835 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3889 Query: 390 PP 391 P Sbjct: 3890 TP 3891 Score = 38.9 bits (89), Expect = 0.010 Identities = 53/242 (21%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 3820 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3879 Query: 219 RLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPPT 270 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 3880 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-- 3937 Query: 271 IGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 3938 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--T 3995 Query: 331 NSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 + ++ P P P TP P+T + +PTP P P+ + P P Sbjct: 3996 TTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 4050 Query: 390 PP 391 P Sbjct: 4051 TP 4052 Score = 37.7 bits (86), Expect = 0.023 Identities = 51/234 (21%), Positives = 80/234 (34%), Gaps = 31/234 (13%) Query: 165 PARTGTLSRTNPP----TQKPPSPPMSGRGTLGRN--TPYKTLEPVKPPTVPNDYMTSPA 218 P TGT + T P T P+P +G T T T+ P PT T+P Sbjct: 3981 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 4040 Query: 219 RLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGS 278 + +P T + Q P T ++ TP+P G P + Sbjct: 4041 TTTTTVTPTPTPTGTQTPTTTPITT-----------------TTTVTPTPTPTGTQTPTT 4083 Query: 279 APGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPP 338 P + T+T + + T +T+ T + T + P+ + ++ P Sbjct: 4084 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI--TTTTTVTPT 4141 Query: 339 PPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPP 391 P P TP P+T + +PTP P P+ + P P P Sbjct: 4142 PTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4190 Score = 37.4 bits (85), Expect = 0.030 Identities = 51/243 (20%), Positives = 84/243 (34%), Gaps = 28/243 (11%) Query: 168 TGTLSRTNPPTQKP----------PSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSP 217 T T PPT P P+P + T T T+ P PT T+P Sbjct: 1887 TTTTENPTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 1946 Query: 218 ARLGSQHSPGRTASLNQRPRTH--------SGSSGGSGSRENSGSSSIGIPIAVPTPSPP 269 + +P T + Q P T + + +G++ + + PTP+P Sbjct: 1947 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP- 2005 Query: 270 TIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYS 329 G P + P + T+T + + T +T+ T + T + P+ Sbjct: 2006 -TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI-- 2062 Query: 330 QNSISIAPPPPPMPQLTP-QIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPP 388 + ++ P P P TP P+T + +PTP P P+ + P Sbjct: 2063 TTTTTVTPTPTPTGTQTPTTTPIT-----TTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2117 Query: 389 PPP 391 P P Sbjct: 2118 PTP 2120 Score = 35.8 bits (81), Expect = 0.089 Identities = 61/237 (25%), Positives = 81/237 (34%), Gaps = 32/237 (13%) Query: 165 PARTGT-----LSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPAR 219 P T T L+ +NPP + S P + R T T TL PP + MTS A Sbjct: 4198 PTHTSTAPIAELTTSNPPPES--STPQTSRSTSSPLTESTTLLSTLPPAIE---MTSTAP 4252 Query: 220 LGSQHSPGRTA---SLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPA-A 275 + +P T+ +L+ P T + G +GSSS P V T + P Sbjct: 4253 PSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPT 4312 Query: 276 PGSAPGSQYGTMTRQISRH-------NSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLY 328 P S P T R N T + Y T T F ++ + Sbjct: 4313 PLSTPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYNGTYGDTCYF-VNCSLSCTLEF 4371 Query: 329 SQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPP 385 S P P P P + P + PTP PP + P FD PP Sbjct: 4372 YNWSCPSTPSPTPTPSKSTPTP------SKPSSTPSKPTPGTKPP--ECPDFD--PP 4418 >gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] Length = 1220 Score = 60.8 bits (146), Expect = 3e-09 Identities = 26/52 (50%), Positives = 35/52 (67%) Query: 423 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474 +V+ +YDYT DDEL+F +G II V+ K D W++G N GLFP NYV+ Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210 Score = 47.0 bits (110), Expect = 4e-05 Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 1/61 (1%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 472 PA P E+ +A+Y Y + +L+F +G +I V KK+ D W+ G G+FP NY Sbjct: 996 PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTGTVGDKAGVFPSNY 1054 Query: 473 V 473 V Sbjct: 1055 V 1055 Score = 38.9 bits (89), Expect = 0.010 Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 7/62 (11%) Query: 418 KNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNY 472 K I +V+A YT ++L+ G +I + KKN GW+EG R G FP NY Sbjct: 1075 KPEIAQVIA--SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132 Query: 473 VE 474 V+ Sbjct: 1133 VK 1134 Score = 33.9 bits (76), Expect = 0.34 Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 7/58 (12%) Query: 426 AIYDYTKDKDDELSFMEGAIIYV-------IKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y + DE++ G I+ V + + GW G TG FP NY E I Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804 Score = 33.5 bits (75), Expect = 0.44 Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 1/51 (1%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y + KD+ L+F + +I V+++ D W+ G G FP +YV+ I Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLI 969 >gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] Length = 1721 Score = 60.8 bits (146), Expect = 3e-09 Identities = 26/52 (50%), Positives = 35/52 (67%) Query: 423 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474 +V+ +YDYT DDEL+F +G II V+ K D W++G N GLFP NYV+ Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210 Score = 47.0 bits (110), Expect = 4e-05 Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 1/61 (1%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 472 PA P E+ +A+Y Y + +L+F +G +I V KK+ D W+ G G+FP NY Sbjct: 996 PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTGTVGDKAGVFPSNY 1054 Query: 473 V 473 V Sbjct: 1055 V 1055 Score = 38.9 bits (89), Expect = 0.010 Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 7/62 (11%) Query: 418 KNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNY 472 K I +V+A YT ++L+ G +I + KKN GW+EG R G FP NY Sbjct: 1075 KPEIAQVIA--SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132 Query: 473 VE 474 V+ Sbjct: 1133 VK 1134 Score = 33.9 bits (76), Expect = 0.34 Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 7/58 (12%) Query: 426 AIYDYTKDKDDELSFMEGAIIYV-------IKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y + DE++ G I+ V + + GW G TG FP NY E I Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804 Score = 33.5 bits (75), Expect = 0.44 Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 1/51 (1%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y + KD+ L+F + +I V+++ D W+ G G FP +YV+ I Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLI 969 >gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo sapiens] Length = 824 Score = 60.1 bits (144), Expect = 4e-09 Identities = 75/330 (22%), Positives = 117/330 (35%), Gaps = 22/330 (6%) Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214 L H +N P A S PP PP PP+ R +T +P + Sbjct: 328 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 385 Query: 215 TSPARLGSQHSPGRTASLNQR-----PRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPP 269 + P + ++ PG+++ L P T + G R+ SS +G P+P P Sbjct: 386 SEPRSI-FEYEPGKSSILQHERPPPLPTTPTPVPREPG-RKPLSSSRLGEVTGSPSPPPR 443 Query: 270 TIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYS 329 + P AP + TR + SSG + Q ++ Sbjct: 444 SGAPTPSSRAPAL---SPTRPPKKPLDYVQDHSSGVFNEASLY------QSSIDRSLERP 494 Query: 330 QNSISIAPPPPPMPQLTPQI-PLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPP 388 +S S+A + P + P G + + P F S P P Sbjct: 495 MSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSP 554 Query: 389 PPPVDYEDEEAAVVQYNDP--YADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAII 446 D E + D A + P+ A+YD+ ELSF +G + Sbjct: 555 SRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTV 614 Query: 447 YVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 Y+++K D WYEG + G+FP +YVE + Sbjct: 615 YILRKIDQNWYEGEHHGRVGIFPISYVEKL 644 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 386 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 442 P PP P Y + + N P P + +N E A+Y+YT +DEL E Sbjct: 732 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 788 Query: 443 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 476 +I V++K DDGW+ G R G FPGNYV+ + Sbjct: 789 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824 Score = 52.4 bits (124), Expect = 9e-07 Identities = 81/342 (23%), Positives = 116/342 (33%), Gaps = 78/342 (22%) Query: 172 SRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPG--RT 229 SR T P PP SG T P L P +PP P DY+ HS G Sbjct: 429 SRLGEVTGSPSPPPRSGAPTPSSRAP--ALSPTRPPKKPLDYV-------QDHSSGVFNE 479 Query: 230 ASLNQ--------RPRTHSGSSGGSGSRENSG------------SSSIGIPIAVPTP-SP 268 ASL Q RP + + + R S S+S P V P S Sbjct: 480 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS 539 Query: 269 PTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLY 328 T+ + S+P S R+ R S+T + R T + P Sbjct: 540 TTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFK 599 Query: 329 SQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSP-------TPPPPPPPDDIPMFD 381 +Q S ++ + +I + + P TPP P Sbjct: 600 AQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP------- 652 Query: 382 DSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFM 441 + PPPP P + I + +A Y++ D + ELS Sbjct: 653 -ARPPPPAQPGE---------------------------IGEAIAKYNFNADTNVELSLR 684 Query: 442 EGAIIYVIKKNDDGWYEGV---CNRVTGLFPGNYVESIMHYT 480 +G + ++K+ D WYEG NR G+FP +YVE + T Sbjct: 685 KGDRVILLKRVDQNWYEGKIPGTNR-QGIFPVSYVEVVKKNT 725 Score = 40.8 bits (94), Expect = 0.003 Identities = 47/200 (23%), Positives = 74/200 (37%), Gaps = 27/200 (13%) Query: 207 PTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTP 266 P N + +P H +T + ++HS +S + +SS P VP P Sbjct: 300 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK----DASSPVPPPHVPPP 355 Query: 267 SPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGP 326 PP + P S + R++ + S Y S Q P Sbjct: 356 VPP-LRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPP------ 408 Query: 327 LYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPP----PPPPDDIPMFDD 382 + P P+P+ + PL+ +R+ E + SP+PPP P P P Sbjct: 409 -------PLPTTPTPVPREPGRKPLSS--SRLGE-VTGSPSPPPRSGAPTPSSRAPAL-- 456 Query: 383 SPPPPPPPPVDYEDEEAAVV 402 SP PP P+DY + ++ V Sbjct: 457 SPTRPPKKPLDYVQDHSSGV 476 >gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo sapiens] Length = 731 Score = 60.1 bits (144), Expect = 4e-09 Identities = 75/330 (22%), Positives = 117/330 (35%), Gaps = 22/330 (6%) Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214 L H +N P A S PP PP PP+ R +T +P + Sbjct: 235 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 292 Query: 215 TSPARLGSQHSPGRTASLNQR-----PRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPP 269 + P + ++ PG+++ L P T + G R+ SS +G P+P P Sbjct: 293 SEPRSI-FEYEPGKSSILQHERPPPLPTTPTPVPREPG-RKPLSSSRLGEVTGSPSPPPR 350 Query: 270 TIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYS 329 + P AP + TR + SSG + Q ++ Sbjct: 351 SGAPTPSSRAPAL---SPTRPPKKPLDYVQDHSSGVFNEASLY------QSSIDRSLERP 401 Query: 330 QNSISIAPPPPPMPQLTPQI-PLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPP 388 +S S+A + P + P G + + P F S P P Sbjct: 402 MSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSP 461 Query: 389 PPPVDYEDEEAAVVQYNDP--YADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAII 446 D E + D A + P+ A+YD+ ELSF +G + Sbjct: 462 SRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTV 521 Query: 447 YVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 Y+++K D WYEG + G+FP +YVE + Sbjct: 522 YILRKIDQNWYEGEHHGRVGIFPISYVEKL 551 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 386 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 442 P PP P Y + + N P P + +N E A+Y+YT +DEL E Sbjct: 639 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 695 Query: 443 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 476 +I V++K DDGW+ G R G FPGNYV+ + Sbjct: 696 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731 Score = 52.4 bits (124), Expect = 9e-07 Identities = 81/342 (23%), Positives = 116/342 (33%), Gaps = 78/342 (22%) Query: 172 SRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPG--RT 229 SR T P PP SG T P L P +PP P DY+ HS G Sbjct: 336 SRLGEVTGSPSPPPRSGAPTPSSRAP--ALSPTRPPKKPLDYV-------QDHSSGVFNE 386 Query: 230 ASLNQ--------RPRTHSGSSGGSGSRENSG------------SSSIGIPIAVPTP-SP 268 ASL Q RP + + + R S S+S P V P S Sbjct: 387 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSS 446 Query: 269 PTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLY 328 T+ + S+P S R+ R S+T + R T + P Sbjct: 447 TTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFK 506 Query: 329 SQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSP-------TPPPPPPPDDIPMFD 381 +Q S ++ + +I + + P TPP P Sbjct: 507 AQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP------- 559 Query: 382 DSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFM 441 + PPPP P + I + +A Y++ D + ELS Sbjct: 560 -ARPPPPAQPGE---------------------------IGEAIAKYNFNADTNVELSLR 591 Query: 442 EGAIIYVIKKNDDGWYEGV---CNRVTGLFPGNYVESIMHYT 480 +G + ++K+ D WYEG NR G+FP +YVE + T Sbjct: 592 KGDRVILLKRVDQNWYEGKIPGTNR-QGIFPVSYVEVVKKNT 632 Score = 40.8 bits (94), Expect = 0.003 Identities = 47/200 (23%), Positives = 74/200 (37%), Gaps = 27/200 (13%) Query: 207 PTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTP 266 P N + +P H +T + ++HS +S + +SS P VP P Sbjct: 207 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK----DASSPVPPPHVPPP 262 Query: 267 SPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGP 326 PP + P S + R++ + S Y S Q P Sbjct: 263 VPP-LRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPP------ 315 Query: 327 LYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPP----PPPPDDIPMFDD 382 + P P+P+ + PL+ +R+ E + SP+PPP P P P Sbjct: 316 -------PLPTTPTPVPREPGRKPLSS--SRLGE-VTGSPSPPPRSGAPTPSSRAPAL-- 363 Query: 383 SPPPPPPPPVDYEDEEAAVV 402 SP PP P+DY + ++ V Sbjct: 364 SPTRPPKKPLDYVQDHSSGV 383 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 60.1 bits (144), Expect = 4e-09 Identities = 61/220 (27%), Positives = 82/220 (37%), Gaps = 32/220 (14%) Query: 175 NPPTQKPPSPPMSGRGTLGRNTP-YKTLEPVK-PPTVPNDYMTSPARLGSQHSPGRTA-S 231 +PP Q PSPP+S T P L P++ PP+ P SP S +P A Sbjct: 600 SPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 659 Query: 232 LNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQI 291 L Q P + S P+ P SPP P +P + P SQ + Sbjct: 660 LLQAPFSPPPSP----------------PVQAPF-SPPASPPVSPSATPPSQ---APPSL 699 Query: 292 SRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPL 351 + + +PS T A P + PL + P PP P ++P Sbjct: 700 AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL------QVPPSPPASPPMSPSATP 753 Query: 352 TGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPP 391 RV +A P PP PP +PM + PPP PP Sbjct: 754 P---PRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPP 790 Score = 54.7 bits (130), Expect = 2e-07 Identities = 67/246 (27%), Positives = 93/246 (37%), Gaps = 29/246 (11%) Query: 167 RTGTLSRTNPPTQKPPS--PPMSGRGTLGRNTPYKTLEPVKPPT---VPNDYMTSPARLG 221 +T S T PP + PS PP + TP+ P P P +T+P Sbjct: 524 QTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTP---- 579 Query: 222 SQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTP-SPPTIG-------P 273 P T S P + + S + S + P+A P P +PP + P Sbjct: 580 ----PPETPSSIATPPPQAPPALASPPLQGLPSPPLS-PLATPPPQAPPXLALPPLQAPP 634 Query: 274 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFS--AQPHVNGGPLY-SQ 330 + P S P S T + Q + + +P V A FS A P V+ SQ Sbjct: 635 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 694 Query: 331 NSISIAPPP---PPMPQLTPQI-PLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPP 386 S+A PP PP P +P + P + +A P PP PP PM + PP Sbjct: 695 APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP 754 Query: 387 PPPPPV 392 P PP+ Sbjct: 755 PRVPPL 760 Score = 48.1 bits (113), Expect = 2e-05 Identities = 59/245 (24%), Positives = 83/245 (33%), Gaps = 35/245 (14%) Query: 169 GTLSRTNPPTQKPPSPPMSGR----GT-LGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQ 223 G T+ PT PSP M+ R GT +G P + P P P ++S S+ Sbjct: 159 GARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSS----ASE 214 Query: 224 HSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQ 283 HS + +R + G SR S S A P SP GP+A G+ Sbjct: 215 HSTTEPSPAARRRPSAGGGLQRPASRSLSSS-------ATPLSSPARSGPSARGTPRAPA 267 Query: 284 YGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPP---- 339 + + + + P++ S+ P P S PPP Sbjct: 268 HPSQPKPKGLQALRPPQVTPPRKDAAPAL-GPLSSSPLATPSP--SGTKARPVPPPDNAA 324 Query: 340 -------PPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP--- 389 PP P L +PL ++ P+PP PP P P PP Sbjct: 325 TPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQ 384 Query: 390 --PPV 392 PP+ Sbjct: 385 TIPPI 389 Score = 44.3 bits (103), Expect = 2e-04 Identities = 63/223 (28%), Positives = 82/223 (36%), Gaps = 37/223 (16%) Query: 176 PPTQKPPSPP----MSGRGTLG-RNTPYKTLEPVK-PPTVPNDYMTSPARLGSQHSPGRT 229 PP Q PPSPP MS T R P P++ PP+ P SP +P Sbjct: 733 PPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPAL 792 Query: 230 AS--LNQRPRTHSGSSGGSGSRENSGSSSIGI-PIAVPTPSPPTIGPAAPGSAPGSQYGT 286 A+ L P S + G S S+S+ + P+A P P P + A P S + Sbjct: 793 ATPPLQALP---SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS 849 Query: 287 MTRQISRHNSTTS-STSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQL 345 T Q R T TS G R T +++AP PPP P Sbjct: 850 PTLQAPRRPPTPGPDTSVSGPRLT-----------------------LALAPGPPPPPSR 886 Query: 346 TPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPP 388 +P L+G + A S TP D P + PPP Sbjct: 887 SPSSTLSGPDLAGHSSSATS-TPEELRGYDSGPEGGAAASPPP 928 Score = 42.7 bits (99), Expect = 7e-04 Identities = 64/280 (22%), Positives = 87/280 (31%), Gaps = 62/280 (22%) Query: 167 RTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSP 226 R G + P P + P GT RN + + P TSP G SP Sbjct: 61 RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSP---GPVSSP 117 Query: 227 GRTASLNQRP-----------------------------------RTHSGSSGGSGS--- 248 GR AS RP R SG + G+ S Sbjct: 118 GR-ASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176 Query: 249 --RENSGSSSIGIPIAVPT--PSPPTIGPAAPGSAPG---------------SQYGTMTR 289 R + + +G+P P+ P PPT GP S+ S G + R Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236 Query: 290 QISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQI 349 SR S++++ S R PS A H + ++ PP P + Sbjct: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296 Query: 350 -PLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPP 388 PL+ P PPP P+ PP PP Sbjct: 297 GPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPP 336 Score = 37.4 bits (85), Expect = 0.030 Identities = 56/241 (23%), Positives = 84/241 (34%), Gaps = 35/241 (14%) Query: 163 NQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGS 222 + PAR+G +R P PS P K L+ ++PP V +P R + Sbjct: 250 SSPARSGPSARGTPRAPAHPSQPKP-----------KGLQALRPPQV------TPPRKDA 292 Query: 223 QHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGS 282 + G +S + SG+ ++ ++ + P +P PSPP P AP S Sbjct: 293 APALGPLSSSPLATPSPSGTKARPVPPPDNAATPL--PATLP-PSPPLATPLP--LAPPS 347 Query: 283 QYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPM 342 + Q T + + TP + A S Q +S S S+ PP P+ Sbjct: 348 PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPL 407 Query: 343 -------------PQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPP 389 P L R + SP+ P PPD P+ P P Sbjct: 408 ALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASP 467 Query: 390 P 390 P Sbjct: 468 P 468 >gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] Length = 888 Score = 59.7 bits (143), Expect = 6e-09 Identities = 50/185 (27%), Positives = 75/185 (40%), Gaps = 17/185 (9%) Query: 296 STTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFV 355 S+++ T++ ++ +Q H++ L I PPP P T P F Sbjct: 333 SSSNPTAAARISELSGLSCSAPSQVHISTTGL-------IVTPPPSSPVTTG--PSFTFP 383 Query: 356 ARVQENIADSPTPPPPPPPDDIP--MFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDP 413 + V A PP PPP + + +PP + D A P Sbjct: 384 SDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRP 443 Query: 414 AWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVT--GLFPGN 471 P Y VAIY YT K+DEL +G + V ++ DGW++G + G+FPGN Sbjct: 444 QTRPSVY----VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGN 499 Query: 472 YVESI 476 YV + Sbjct: 500 YVAPV 504 Score = 53.1 bits (126), Expect = 5e-07 Identities = 71/316 (22%), Positives = 110/316 (34%), Gaps = 49/316 (15%) Query: 191 TLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRE 250 T+ + + V P V N SPA +G H AS P ++ + Sbjct: 592 TVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHS--LASPQPAPLMPGSATHTAAISI 649 Query: 251 NSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTP 310 + S+ + A P SP +I A+ + P + T+ + + SS P Sbjct: 650 SRASAPLACAAAAPLTSP-SITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKP 708 Query: 311 SVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPP 370 ++ + G L + S P P +P + + A + A P PP Sbjct: 709 DKDSKKEKK-----GLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPP 763 Query: 371 P---------PPPDDIPMFD-------------------DSPPPPPPPPVDYEDEEAAVV 402 P D P+ DS P PPP V+ Sbjct: 764 GGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVL 823 Query: 403 QYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCN 462 + P E+ + Y + EL EG I++V KK +DGW++G Sbjct: 824 NESRPVV-----------CERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQ 872 Query: 463 R--VTGLFPGNYVESI 476 R TGLFPG++VE+I Sbjct: 873 RNGKTGLFPGSFVENI 888 Score = 45.1 bits (105), Expect = 1e-04 Identities = 19/51 (37%), Positives = 31/51 (60%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+Y+Y + +L F +G II + ++ D+ WY G N + G FP N+V+ I Sbjct: 141 ALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQII 191 Score = 38.9 bits (89), Expect = 0.010 Identities = 21/53 (39%), Positives = 33/53 (62%), Gaps = 4/53 (7%) Query: 426 AIYDY-TKDKD---DELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474 A+YD+ KDK+ D L F + ++ VI++ D+ W EG+ G+FP +YVE Sbjct: 203 ALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVE 255 >gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo sapiens] Length = 486 Score = 59.7 bits (143), Expect = 6e-09 Identities = 43/154 (27%), Positives = 64/154 (41%), Gaps = 37/154 (24%) Query: 358 VQENIADSPTPPPPPPP--------DDIPMFDDSPPPPPPPPV----DYEDEEAAVVQYN 405 +++ + + PP PP ++ P+++ P P P P DYED E Sbjct: 330 IRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQ 389 Query: 406 DPYADGD----------------------PAWAPKNYIE---KVVAIYDYTKDKDDELSF 440 + +GD PA A + VA+YDY + DELSF Sbjct: 390 EDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSF 449 Query: 441 MEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474 +I I+ D+GW+ G C+ GLFP NYV+ Sbjct: 450 DPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVK 483 >gi|55956916 myosin IE [Homo sapiens] Length = 1108 Score = 59.3 bits (142), Expect = 7e-09 Identities = 63/248 (25%), Positives = 95/248 (38%), Gaps = 38/248 (15%) Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPP----TIGPAAPGSAPGSQYGTMTRQISRHNS 296 G GSR+ G +AV PS +IGP P ++ ++ T Q + ++S Sbjct: 887 GPWSAGGSRQVQFHQGFG-DLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTT--QNTGYSS 943 Query: 297 TTSSTS--------SGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQ 348 T + + GY + + Q+ PH G +Q S+ + PP+P+ Q Sbjct: 944 GTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPR--QQ 1001 Query: 349 IPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPY 408 + V++ E++ D P PPP P Sbjct: 1002 STSSDRVSQTPESL-DFLKVPDQGAAGVRRQTTSRPPPAGGRP----------------- 1043 Query: 409 ADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLF 468 P PK + + A+Y Y DELSF II +IK++ GW+ G GLF Sbjct: 1044 ---KPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLF 1100 Query: 469 PGNYVESI 476 P NYV I Sbjct: 1101 PNNYVTKI 1108 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 58.9 bits (141), Expect = 1e-08 Identities = 67/244 (27%), Positives = 99/244 (40%), Gaps = 36/244 (14%) Query: 163 NQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGS 222 + PAR+G +R P PS P K L+ ++PP V + LG Sbjct: 250 SSPARSGPSARGTPRAPAHPSQPKP-----------KGLQALRPPQVTPPRKDAAPALGP 298 Query: 223 QHS-----PGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPS-PPTI---- 271 S P +A+L +Q P T + S + + +P+A P+PS PP++ Sbjct: 299 LSSSPLATPSPSAALQSQAPPTLPATPHSSSL---TCQLATPLPLAPPSPSAPPSLQTLP 355 Query: 272 -GPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQ 330 PA P S + G+ T Q + H+ S S P T A P + PL + Sbjct: 356 SPPATPPSQATTSLGSPTLQ-ATHSFLPSPPLS------PLATPPPQAPPALALPPLQAP 408 Query: 331 NSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPP---PPPPPDDIPMFDDSPPPP 387 S +PP P+ +PQ P V +Q + P+PP P PP P+ + PP Sbjct: 409 PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS 468 Query: 388 PPPP 391 PP Sbjct: 469 QAPP 472 Score = 52.0 bits (123), Expect = 1e-06 Identities = 67/260 (25%), Positives = 94/260 (36%), Gaps = 37/260 (14%) Query: 169 GTLSRTNPPTQKPPSPPMSGR----GT-LGRNTPYKTLEPVKPPTVP-------NDYMTS 216 G T+ PT PSP M+ R GT +G P + P P P +++ T+ Sbjct: 159 GARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT 218 Query: 217 PARLGSQHSPGRTASLNQRPRTHSGSSGGS--GSRENSGSSSIGIPIAVPTPS------- 267 ++ P L QRP + S SS + S SG S+ G P A PS Sbjct: 219 EPSPAARRRPSAGGGL-QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL 277 Query: 268 ----PPTIGP----AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQ 319 PP + P AAP P S T S + + + + S+T Q + Sbjct: 278 QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATP 337 Query: 320 PHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSP------TPPPPPP 373 + + S+ P PP P L + + SP TPPP P Sbjct: 338 LPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 397 Query: 374 PD-DIPMFDDSPPPPPPPPV 392 P +P P PP PP+ Sbjct: 398 PALALPPLQAPPSPPASPPL 417 Score = 51.2 bits (121), Expect = 2e-06 Identities = 69/242 (28%), Positives = 97/242 (40%), Gaps = 42/242 (17%) Query: 165 PARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQH 224 P+ + L PPT P+ P S T TP P+ PP+ ++P L + Sbjct: 307 PSPSAALQSQAPPTL--PATPHSSSLTCQLATPL----PLAPPSP-----SAPPSLQTLP 355 Query: 225 SPGRTASLNQRPRTHSGSSGGSGSRENSGS---SSIGIPIAVPTP-SPPTIG-------P 273 SP T P + + +S GS + + + S S P+A P P +PP + P Sbjct: 356 SPPAT------PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPP 409 Query: 274 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFS--AQPHVNGGPLY-SQ 330 + P S P S T + Q + + +P V A FS A P V+ SQ Sbjct: 410 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 469 Query: 331 NSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPP-PPPDDIPMFDDSPPPPPP 389 S+A PP +P P P ++ S TPPP PPP P + PPP Sbjct: 470 APPSLAAPPLQVPPSPPASP----------PMSPSATPPPQAPPPLAAPPLQLAKPPPQA 519 Query: 390 PP 391 PP Sbjct: 520 PP 521 Score = 47.0 bits (110), Expect = 4e-05 Identities = 72/307 (23%), Positives = 97/307 (31%), Gaps = 87/307 (28%) Query: 167 RTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSP 226 R G + P P + P GT RN + + P TSP G SP Sbjct: 61 RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSP---GPVSSP 117 Query: 227 GRTASLNQRP-----------------------------------RTHSGSSGGSGS--- 248 GR AS RP R SG + G+ S Sbjct: 118 GR-ASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176 Query: 249 --RENSGSSSIGIPIAVPT--PSPPTIGPAAPGSAPG---------------SQYGTMTR 289 R + + +G+P P+ P PPT GP S+ S G + R Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236 Query: 290 QISRHNSTTSSTSSGGYRRTPSV-----TAQFSAQPHVNG-------------------- 324 SR S++++ S R PS +QP G Sbjct: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296 Query: 325 GPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSP 384 GPL S + +P Q P +P T + + +A +P P PP P P P Sbjct: 297 GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLA-TPLPLAPPSPSAPPSLQTLP 355 Query: 385 PPPPPPP 391 PP PP Sbjct: 356 SPPATPP 362 Score = 46.6 bits (109), Expect = 5e-05 Identities = 62/235 (26%), Positives = 81/235 (34%), Gaps = 37/235 (15%) Query: 165 PARTGTLSRTNPPTQKP----PSPPMSGRGTLGRNTPYK-TLEPVK-PPTVPNDYMTSPA 218 P T S +P Q PSPP+S T P L P++ PP+ P SP Sbjct: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 420 Query: 219 RLGSQHSPGRTA-SLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPG 277 S +P A L Q P + S P+ P SPP P +P Sbjct: 421 ATPSPQAPNALAVHLLQAPFSPPPSP----------------PVQAPF-SPPASPPVSPS 463 Query: 278 SAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAP 337 + P SQ ++ + +PS T A P + PL +A Sbjct: 464 ATPPSQ---APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL------QLAK 514 Query: 338 PPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPV 392 PPP P PL + A P P P +PM + PPP PPV Sbjct: 515 PPPQAPPALATPPLQALPSPP----ASFPGQAPFSPSASLPMSPLATPPPQAPPV 565 Score = 45.1 bits (105), Expect = 1e-04 Identities = 59/217 (27%), Positives = 77/217 (35%), Gaps = 38/217 (17%) Query: 176 PPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQR 235 PP Q PPSPP S P + PP P P +L ++ P +L Sbjct: 477 PPLQVPPSPPAS---------PPMSPSATPPPQAPPPLAAPPLQL-AKPPPQAPPALATP 526 Query: 236 PRTHSGSSGGS--GSRENSGSSSIGI-PIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQIS 292 P S S G S S+S+ + P+A P P P + A P S + T Q Sbjct: 527 PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 586 Query: 293 RHNSTTS-STSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPL 351 R T TS G R T +++AP PPP P +P L Sbjct: 587 RRPPTPGPDTSVSGPRLT-----------------------LALAPGPPPPPSRSPSSTL 623 Query: 352 TGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPP 388 +G + A S TP D P + PPP Sbjct: 624 SGPDLAGHSSSATS-TPEELRGYDSGPEGGAAASPPP 659 >gi|150417989 cyclin K isoform 1 [Homo sapiens] Length = 580 Score = 58.9 bits (141), Expect = 1e-08 Identities = 67/237 (28%), Positives = 86/237 (36%), Gaps = 33/237 (13%) Query: 177 PTQKPPSPPMSGRGTL-GRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQR 235 P+ +P SP R + K EP PP +P T P + P R L Sbjct: 323 PSPQPSSPRQVKRAVVVSPKEENKAAEP-PPPKIPKIETTHPPLPPAHPPPDRKPPL--- 378 Query: 236 PRTHSGSSGGSGSRENSGSSSIGIPIAV---PTPSPPTIGPAAPGSAPGSQYGTMTRQIS 292 G + G + + + IP P PP + P P P S Y T Sbjct: 379 -AAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPL-PHRPPPPPPSSYMTGM---- 432 Query: 293 RHNSTTSSTSSG-GYRRTPSVTA----QFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTP 347 STTSS SG GY+ S+ + A P G P + + PP PP P + P Sbjct: 433 ---STTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPP 489 Query: 348 QIPLTGFVARVQENIADSPTPPP------PPPPDDIPMFDDSPPPPPP----PPVDY 394 P + + P PPP PPPP +P PP PPP PP Y Sbjct: 490 P-PASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASY 545 Score = 39.7 bits (91), Expect = 0.006 Identities = 63/297 (21%), Positives = 98/297 (32%), Gaps = 43/297 (14%) Query: 140 PIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYK 199 P+D VL+D+ H + L ++ P T + P Q P P + ++ P + Sbjct: 243 PVD--VLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQ-----VQQSQPSQ 295 Query: 200 TLEPVKP----PTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSS 255 + EP +P P P PA+ + SP ++ PR + S EN + Sbjct: 296 SSEPSQPQQKDPQQPAQQQ-QPAQQPKKPSPQPSS-----PRQVKRAVVVSPKEENKAAE 349 Query: 256 SIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQ 315 P P P I P P ++ P V Sbjct: 350 P-------PPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIP 402 Query: 316 FSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLT-------GFVARVQENIADSPT- 367 A P P++ + PPPPP + T G+ + + P+ Sbjct: 403 PPAHP----APVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSY 458 Query: 368 ---PPPPPPPDDIP----MFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAP 417 PP PP +P ++ +PPPPP PP A+ Y P + P Sbjct: 459 GALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNP 515 Score = 37.0 bits (84), Expect = 0.040 Identities = 28/95 (29%), Positives = 36/95 (37%), Gaps = 8/95 (8%) Query: 326 PLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPP 385 P Q P P P Q+ V+ +EN A P PP IP + + P Sbjct: 310 PAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPK------IPKIETTHP 363 Query: 386 PPPP--PPVDYEDEEAAVVQYNDPYADGDPAWAPK 418 P PP PP D + AA + +P D PK Sbjct: 364 PLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPK 398 >gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo sapiens] Length = 492 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 386 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 442 P PP P Y + + N P P + +N E A+Y+YT +DEL E Sbjct: 400 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 456 Query: 443 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 476 +I V++K DDGW+ G R G FPGNYV+ + Sbjct: 457 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492 Score = 52.8 bits (125), Expect = 7e-07 Identities = 64/287 (22%), Positives = 97/287 (33%), Gaps = 31/287 (10%) Query: 207 PTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTP 266 P N + +P H +T + ++HS +S + +SS P VP P Sbjct: 40 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK----DASSPVPPPHVPPP 95 Query: 267 SPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGP 326 PP + P S + R++ + S Y S Q H Sbjct: 96 VPP-LRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ-----HERPAS 149 Query: 327 LYS-------QNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIP- 378 LY + +S A + P G + D P D+P Sbjct: 150 LYQSSIDRSLERPMSSASMASDFRKRRKSEPAVG----PPRGLGDQSASRTSPGRVDLPG 205 Query: 379 -------MFDDSPPPPPPPPVDYEDEEAAVVQYNDP--YADGDPAWAPKNYIEKVVAIYD 429 F S P P D E + D A + P+ A+YD Sbjct: 206 SSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYD 265 Query: 430 YTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 + ELSF +G +Y+++K D WYEG + G+FP +YVE + Sbjct: 266 FKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 312 Score = 47.8 bits (112), Expect = 2e-05 Identities = 81/368 (22%), Positives = 131/368 (35%), Gaps = 85/368 (23%) Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214 L H +N P A S PP PP PP+ R +T +P + Sbjct: 68 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 125 Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273 + P + ++ PG+++ L ++RP + SS S+S+ S P +GP Sbjct: 126 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 184 Query: 274 -----------AAPGSA--PGSQYGTMTRQISRHNSTTSSTSSGGYRRTP-----SVTAQ 315 +PG PGS T+T+ + +S+ SS S R +P ++T Sbjct: 185 PRGLGDQSASRTSPGRVDLPGSST-TLTKSFT--SSSPSSPSRAKDRESPRSYSSTLTDM 241 Query: 316 FSAQPHVNGGP-------------LYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENI 362 + P G +Q S ++ + +I + + Sbjct: 242 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 301 Query: 363 ADSP-------TPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAW 415 P TPP P + PPPP P + Sbjct: 302 GIFPISYVEKLTPPEKAQP--------ARPPPPAQPGE---------------------- 331 Query: 416 APKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFPGNY 472 I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP +Y Sbjct: 332 -----IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFPVSY 385 Query: 473 VESIMHYT 480 VE + T Sbjct: 386 VEVVKKNT 393 >gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo sapiens] Length = 1004 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 386 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 442 P PP P Y + + N P P + +N E A+Y+YT +DEL E Sbjct: 912 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 968 Query: 443 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 476 +I V++K DDGW+ G R G FPGNYV+ + Sbjct: 969 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004 Score = 51.6 bits (122), Expect = 2e-06 Identities = 21/51 (41%), Positives = 32/51 (62%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE + Sbjct: 774 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 4/71 (5%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFP 469 P A I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP Sbjct: 836 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFP 894 Query: 470 GNYVESIMHYT 480 +YVE + T Sbjct: 895 VSYVEVVKKNT 905 Score = 33.5 bits (75), Expect = 0.44 Identities = 38/165 (23%), Positives = 64/165 (38%), Gaps = 19/165 (11%) Query: 156 LKAKHGNNQPARTGTLSRTNPPTQKPPS-PPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214 L H +N P S PP PP PP+ R +T +P + Sbjct: 53 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 110 Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273 + P + ++ PG+++ L ++RP + SS S+S+ S P +GP Sbjct: 111 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 169 Query: 274 -----------AAPG--SAPGSQYGTMTRQISRHNSTTSSTSSGG 305 +PG PGS T+T+ + + ++ S + GG Sbjct: 170 PRGLGDQSASRTSPGRVDLPGSS-TTLTKSFTSSSPSSPSRAKGG 213 >gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo sapiens] Length = 661 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 386 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 442 P PP P Y + + N P P + +N E A+Y+YT +DEL E Sbjct: 569 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 625 Query: 443 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 476 +I V++K DDGW+ G R G FPGNYV+ + Sbjct: 626 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661 Score = 51.6 bits (122), Expect = 2e-06 Identities = 21/51 (41%), Positives = 32/51 (62%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE + Sbjct: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 481 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 4/71 (5%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFP 469 P A I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP Sbjct: 493 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFP 551 Query: 470 GNYVESIMHYT 480 +YVE + T Sbjct: 552 VSYVEVVKKNT 562 >gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo sapiens] Length = 644 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 386 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 442 P PP P Y + + N P P + +N E A+Y+YT +DEL E Sbjct: 552 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 608 Query: 443 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 476 +I V++K DDGW+ G R G FPGNYV+ + Sbjct: 609 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644 Score = 53.1 bits (126), Expect = 5e-07 Identities = 67/298 (22%), Positives = 101/298 (33%), Gaps = 36/298 (12%) Query: 196 TPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSS 255 T +K + V P + N P H +T + ++HS +S + +S Sbjct: 186 TMFKQIHMVHKPGLYN-----PPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFK----DAS 236 Query: 256 SIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQ 315 S P VP P PP + P S + R++ + S Y S Q Sbjct: 237 SPVPPPHVPPPVPP-LRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ 295 Query: 316 FSAQPHVNGGPLYS-------QNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTP 368 H LY + +S A + P G + D Sbjct: 296 -----HERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVG----PPRGLGDQSAS 346 Query: 369 PPPPPPDDIP--------MFDDSPPPPPPPPVDYEDEEAAVVQYNDP--YADGDPAWAPK 418 P D+P F S P P D E + D A + P+ Sbjct: 347 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 406 Query: 419 NYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE + Sbjct: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 464 Score = 47.8 bits (112), Expect = 2e-05 Identities = 81/368 (22%), Positives = 131/368 (35%), Gaps = 85/368 (23%) Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214 L H +N P A S PP PP PP+ R +T +P + Sbjct: 220 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 277 Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273 + P + ++ PG+++ L ++RP + SS S+S+ S P +GP Sbjct: 278 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 336 Query: 274 -----------AAPGSA--PGSQYGTMTRQISRHNSTTSSTSSGGYRRTP-----SVTAQ 315 +PG PGS T+T+ + +S+ SS S R +P ++T Sbjct: 337 PRGLGDQSASRTSPGRVDLPGSST-TLTKSFT--SSSPSSPSRAKDRESPRSYSSTLTDM 393 Query: 316 FSAQPHVNGGP-------------LYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENI 362 + P G +Q S ++ + +I + + Sbjct: 394 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 453 Query: 363 ADSP-------TPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAW 415 P TPP P + PPPP P + Sbjct: 454 GIFPISYVEKLTPPEKAQP--------ARPPPPAQPGE---------------------- 483 Query: 416 APKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFPGNY 472 I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP +Y Sbjct: 484 -----IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFPVSY 537 Query: 473 VESIMHYT 480 VE + T Sbjct: 538 VEVVKKNT 545 >gi|203098098 shroom family member 3 protein [Homo sapiens] Length = 1996 Score = 58.2 bits (139), Expect = 2e-08 Identities = 66/266 (24%), Positives = 97/266 (36%), Gaps = 40/266 (15%) Query: 169 GTLSRTNPPTQKP-PSPPMSGRGTLGRNTPYKTLEPVKPP---TVPNDYMTSPARLGSQH 224 GTL ++ P P PP++G L +T L P+ P +P+ Y + + G Q Sbjct: 1318 GTLDHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQP 1377 Query: 225 SPGRTASLNQRPRTHS-----GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSA 279 P T ++ R H+ G G G G G V P P P S Sbjct: 1378 LPPYTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEE-GTRKRVSLPQWP------PPSR 1430 Query: 280 PGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFS-AQPHVNGGPLYSQNSISIA-- 336 + + +S + Y++ S+ + S + P G + IS+ Sbjct: 1431 AKWAHAAREDSLPEESSAPDFANLKHYQKQQSLPSLCSTSDPDTPLGAPSTPGRISLRIS 1490 Query: 337 -----PPPPPMPQLTPQIPLTGFVARVQENIADSPT------PPPPPPPDDIPMF--DDS 383 PPP ++ FV SPT PPPPPP + P++ DD Sbjct: 1491 ESVLRDSPPPHEDYEDEV----FVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDF 1546 Query: 384 PPPPP----PPPVDYEDEEAAVVQYN 405 PPPPP +D ED E +N Sbjct: 1547 PPPPPHTVCEAQLDSEDPEGPRPSFN 1572 >gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo sapiens] Length = 1100 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 386 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 442 P PP P Y + + N P P + +N E A+Y+YT +DEL E Sbjct: 1008 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 1064 Query: 443 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 476 +I V++K DDGW+ G R G FPGNYV+ + Sbjct: 1065 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100 Score = 51.6 bits (122), Expect = 2e-06 Identities = 21/51 (41%), Positives = 32/51 (62%) Query: 426 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 476 A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE + Sbjct: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 4/71 (5%) Query: 413 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFP 469 P A I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP Sbjct: 932 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFP 990 Query: 470 GNYVESIMHYT 480 +YVE + T Sbjct: 991 VSYVEVVKKNT 1001 Score = 33.5 bits (75), Expect = 0.44 Identities = 38/165 (23%), Positives = 64/165 (38%), Gaps = 19/165 (11%) Query: 156 LKAKHGNNQPARTGTLSRTNPPTQKPPS-PPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214 L H +N P S PP PP PP+ R +T +P + Sbjct: 149 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 206 Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273 + P + ++ PG+++ L ++RP + SS S+S+ S P +GP Sbjct: 207 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 265 Query: 274 -----------AAPG--SAPGSQYGTMTRQISRHNSTTSSTSSGG 305 +PG PGS T+T+ + + ++ S + GG Sbjct: 266 PRGLGDQSASRTSPGRVDLPGSS-TTLTKSFTSSSPSSPSRAKGG 309 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.311 0.130 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,158,237 Number of Sequences: 37866 Number of extensions: 1733239 Number of successful extensions: 32159 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 640 Number of HSP's successfully gapped in prelim test: 1164 Number of HSP's that attempted gapping in prelim test: 12382 Number of HSP's gapped (non-prelim): 10394 length of query: 481 length of database: 18,247,518 effective HSP length: 106 effective length of query: 375 effective length of database: 14,233,722 effective search space: 5337645750 effective search space used: 5337645750 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.