Search of human proteins with 61742784

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61742784 leucine rich repeat and death domain containing
protein isoform 1 [Homo sapiens]
         (910 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61742784 leucine rich repeat and death domain containing prot...  1817   0.0  
gi|61742786 leucine rich repeat and death domain containing prot...  1774   0.0  
gi|61742782 leucine rich repeat and death domain containing prot...  1499   0.0  
gi|30181233 leucine-rich repeats and calponin homology (CH) doma...   116   8e-26
gi|45827729 scribble isoform b [Homo sapiens]                         116   1e-25
gi|45827731 scribble isoform a [Homo sapiens]                         116   1e-25
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]        112   2e-24
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]         112   2e-24
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]           111   3e-24
gi|153792305 leucine rich repeat containing 58 [Homo sapiens]         110   8e-24
gi|16904383 leucine rich repeat containing 7 [Homo sapiens]           109   1e-23
gi|4503743 flightless I homolog [Homo sapiens]                        108   2e-23
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]          108   2e-23
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]          108   2e-23
gi|40217803 leucine rich repeat containing 8 family, member E [H...   105   2e-22
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...   102   2e-21
gi|62241040 leucine rich repeat containing 8 family, member A [H...   100   8e-21
gi|187829877 leucine rich repeat containing 8 family, member A [...   100   8e-21
gi|187829871 leucine rich repeat containing 8 family, member A [...   100   8e-21
gi|157743290 leucine rich repeat containing 30 [Homo sapiens]          99   1e-20
gi|14249428 leucine-rich repeats and calponin homology (CH) doma...    99   2e-20
gi|19923729 leucine rich repeat containing 8 family, member C [H...    97   9e-20
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]           96   2e-19
gi|197333692 leucine rich repeat containing 8 family, member B [...    96   2e-19
gi|21245134 leucine rich repeat containing 8 family, member B [H...    96   2e-19
gi|33285015 leucine rich repeat containing 28 [Homo sapiens]           96   2e-19
gi|238908508 leucine-rich repeat and death domain-containing pro...    94   4e-19
gi|33859670 leucine-rich repeats and calponin homology (CH) doma...    93   1e-18
gi|167466264 leucine rich repeat containing 18 [Homo sapiens]          92   3e-18
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        91   4e-18

>gi|61742784 leucine rich repeat and death domain containing protein
           isoform 1 [Homo sapiens]
          Length = 910

 Score = 1817 bits (4706), Expect = 0.0
 Identities = 910/910 (100%), Positives = 910/910 (100%)

Query: 1   MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60
           MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ
Sbjct: 1   MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60

Query: 61  LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120
           LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG
Sbjct: 61  LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120

Query: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
           LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH
Sbjct: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180

Query: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
           NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR
Sbjct: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240

Query: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
           SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300

Query: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360
           DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL
Sbjct: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360

Query: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420
           LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS
Sbjct: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420

Query: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480
           WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF
Sbjct: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480

Query: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540
           PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS
Sbjct: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540

Query: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600
           GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV
Sbjct: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600

Query: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660
           GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV
Sbjct: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660

Query: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQ 720
           EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQ
Sbjct: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQ 720

Query: 721 VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG 780
           VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG
Sbjct: 721 VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG 780

Query: 781 DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA 840
           DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA
Sbjct: 781 DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA 840

Query: 841 ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS 900
           ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS
Sbjct: 841 ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS 900

Query: 901 APQPPEPAQA 910
           APQPPEPAQA
Sbjct: 901 APQPPEPAQA 910


>gi|61742786 leucine rich repeat and death domain containing protein
           isoform 3 [Homo sapiens]
          Length = 893

 Score = 1774 bits (4595), Expect = 0.0
 Identities = 893/910 (98%), Positives = 893/910 (98%), Gaps = 17/910 (1%)

Query: 1   MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60
           MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ
Sbjct: 1   MAATVEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ 60

Query: 61  LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120
           LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG
Sbjct: 61  LLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAG 120

Query: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
           LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH
Sbjct: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180

Query: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240
           NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR
Sbjct: 181 NRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLR 240

Query: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
           SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300

Query: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360
           DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL
Sbjct: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLACGVRLQFPAGATATPITIRYRL 360

Query: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420
           LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS
Sbjct: 361 LLPEPGLVPLGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNS 420

Query: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480
           WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF
Sbjct: 421 WGDLETYLEEEAPQRLWAHCQVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIF 480

Query: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540
           PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS
Sbjct: 481 PPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPS 540

Query: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600
           GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV
Sbjct: 541 GITGLSLDRSRLHLLYWAPPAATWDDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCV 600

Query: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660
           GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV
Sbjct: 601 GGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTV 660

Query: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQ 720
           EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKE                 
Sbjct: 661 EMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSHLKNVKE----------------- 703

Query: 721 VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG 780
           VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG
Sbjct: 704 VSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLG 763

Query: 781 DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA 840
           DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA
Sbjct: 764 DAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWA 823

Query: 841 ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS 900
           ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS
Sbjct: 824 ERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSS 883

Query: 901 APQPPEPAQA 910
           APQPPEPAQA
Sbjct: 884 APQPPEPAQA 893


>gi|61742782 leucine rich repeat and death domain containing protein
           isoform 2 [Homo sapiens]
          Length = 753

 Score = 1499 bits (3881), Expect = 0.0
 Identities = 753/764 (98%), Positives = 753/764 (98%), Gaps = 11/764 (1%)

Query: 147 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
           MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL
Sbjct: 1   MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60

Query: 207 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 266
           DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT
Sbjct: 61  DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120

Query: 267 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 326
           RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF
Sbjct: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180

Query: 327 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 386
           PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH
Sbjct: 181 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 240

Query: 387 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 446
           GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS
Sbjct: 241 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 300

Query: 447 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 506
           WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL
Sbjct: 301 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 360

Query: 507 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 566
           LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD
Sbjct: 361 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 420

Query: 567 ITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 626
           ITAQVVLELTHL           YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD
Sbjct: 421 ITAQVVLELTHL-----------YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 469

Query: 627 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 686
           PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV
Sbjct: 470 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 529

Query: 687 EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD 746
           EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD
Sbjct: 530 EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD 589

Query: 747 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 806
           ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV
Sbjct: 590 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 649

Query: 807 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 866
           ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA
Sbjct: 650 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 709

Query: 867 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 910
           EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA
Sbjct: 710 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 753


>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
           containing 4 [Homo sapiens]
          Length = 683

 Score =  116 bits (291), Expect = 8e-26
 Identities = 78/188 (41%), Positives = 107/188 (56%), Gaps = 8/188 (4%)

Query: 114 LTNLPAGLS---GLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
           L + P G +    L+ +   DLS N    +P    Q+  L  L L HNCL  L  ALG L
Sbjct: 54  LKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNL 113

Query: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ 230
            ALT+L ++ N+L  LPP +  L  L+ L +S N L  LPP+IG LGSL +L+++SN LQ
Sbjct: 114 TALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQ 172

Query: 231 SLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPP---ELLDAPF 287
           SLP+ L GL SLR L +  N L+++P +L  LPL+ RLD   N++  +P     L     
Sbjct: 173 SLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLV-RLDFSCNRVSRIPVSFCRLRHLQV 231

Query: 288 VRLQGNPL 295
           + L  NPL
Sbjct: 232 ILLDSNPL 239



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 71/200 (35%), Positives = 104/200 (52%), Gaps = 28/200 (14%)

Query: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168
           CL  AL NL A       L +L+LS N L  LP  + Q+  L  L++S+N L  LP  +G
Sbjct: 105 CLNPALGNLTA-------LTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIG 156

Query: 169 ALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNR 228
            L +L  L V+ N LQ+LP  L  LS+L+ L++ +N L TLP E+G L  L+ L+ + NR
Sbjct: 157 TLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNR 215

Query: 229 LQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLTRLDLRDNQLRDLPPELLDA 285
           +  +P S   LR L++++L SN L S PA +    +L +   L     Q           
Sbjct: 216 VSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQ----------- 264

Query: 286 PFVRLQGNPLGEASPDAPSS 305
                +G+ LG+ +P  P S
Sbjct: 265 -----RGSALGDLAPSRPPS 279


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score =  116 bits (290), Expect = 1e-25
 Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)

Query: 58  PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
           PL  L   F +L +     L + +L  LP  +  L +LV    + R+ L       L +L
Sbjct: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166

Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
           PA LS L  L  LDL  N LE LP  +  +  L  L L  N LS LP  LG L  L  L 
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226

Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
           V+ NRL+ LP  LG L  L  L LSQNLL  LP  IG L  L  L +  NRL  +  ++ 
Sbjct: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286

Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
              +L  L+L  NLL ++P  L +L  LT L++  N L  LPPE+
Sbjct: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331



 Score =  115 bits (287), Expect = 2e-25
 Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)

Query: 35  GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90
           GN LS    P G  QL    HL +    LQ L  +   L+     +L E  L  LP SLS
Sbjct: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171

Query: 91  CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136
            L     L L G       DTLGA          R  L+ LP  L  L  L  LD+S N 
Sbjct: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231

Query: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
           LE LPA +  +  L  LLLS N L  LP+ +G L  L+ L V  NRL  +  A+G    L
Sbjct: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291

Query: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
             L L++NLL  LP  +G L  L  LN+  N L++LP  + G  +L +L L  N LA +P
Sbjct: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351

Query: 257 ADLARLPLLTRLDLRDNQLRDLP 279
            +LA    L  LD+  N+L+ LP
Sbjct: 352 PELAHTTELHVLDVAGNRLQSLP 374



 Score =  106 bits (265), Expect = 9e-23
 Identities = 69/171 (40%), Positives = 95/171 (55%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L+ LP G + L  LAHL L+  SL+ LP  V  +  L  L L  N L  LP +L  L  L
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L +  N L+ LP  LGAL  L+ L L +N L  LPPE+G L  L+ L+++ NRL+ LP
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
           A L GL  L  L+L  NLL  +P  + +L  L+ L +  N+L ++   + D
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287



 Score =  103 bits (258), Expect = 6e-22
 Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)

Query: 28  RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75
           R+L  L  N +SL   PG    L +L   +  +            L+++E L L  + D 
Sbjct: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186

Query: 76  QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124
           ++L  TL  LP     LR L L            G  RR          L  LPA L GL
Sbjct: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242

Query: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
             L  L LS N L  LP  + Q++ L  L +  N L E+ EA+G    L+ L +T N L 
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302

Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
            LP +LG L+ L  L++ +N L+ LPPEIGG  +L  L+L  NRL  LP  LA    L +
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362

Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278
           L +  N L S+P  L  L  L  L L +NQ + +
Sbjct: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)

Query: 59  LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
           LQ +  E  R S   +  LL+A  L +LP+    L +L   G    +         +  L
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74

Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
           P  ++    L  LD+S N +  +P  +   + L     S N LS LP+    L +L  L 
Sbjct: 75  PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134

Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
           +    LQ LP  +G L+ L  L+L +NLL +LP  +  L  L +L+L  N L+ LP +L 
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194

Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            L +LR L L  N L+++P +L  L  L  LD+ +N+L +LP EL
Sbjct: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)

Query: 59  LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118
           L+ L   F RL       L +  + +LP  ++    LV     R D         +  +P
Sbjct: 48  LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98

Query: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
             +     L   D S N L  LP    Q+R L  L L+   L  LP  +G L  L  L +
Sbjct: 99  ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158

Query: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
             N L++LP +L  L  L++LDL  N L+ LP  +G L +L EL L  N+L +LP  L  
Sbjct: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218

Query: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
           LR L  L +  N L  +PA+L  L LLT L L  N LR LP
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)

Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
           L  L L  N L  LP    ++  L  L LS N +  LP  +     L  L V+ N +  +
Sbjct: 38  LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97

Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
           P ++     L+  D S N L  LP     L SL  L L    LQ+LP  +  L +L  L 
Sbjct: 98  PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157

Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301
           L  NLL S+PA L+ L  L +LDL  N L  LP  L   P +R   L  N L    P+
Sbjct: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score =  116 bits (290), Expect = 1e-25
 Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)

Query: 58  PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
           PL  L   F +L +     L + +L  LP  +  L +LV    + R+ L       L +L
Sbjct: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166

Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
           PA LS L  L  LDL  N LE LP  +  +  L  L L  N LS LP  LG L  L  L 
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226

Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
           V+ NRL+ LP  LG L  L  L LSQNLL  LP  IG L  L  L +  NRL  +  ++ 
Sbjct: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286

Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
              +L  L+L  NLL ++P  L +L  LT L++  N L  LPPE+
Sbjct: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331



 Score =  115 bits (287), Expect = 2e-25
 Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)

Query: 35  GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90
           GN LS    P G  QL    HL +    LQ L  +   L+     +L E  L  LP SLS
Sbjct: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171

Query: 91  CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136
            L     L L G       DTLGA          R  L+ LP  L  L  L  LD+S N 
Sbjct: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231

Query: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
           LE LPA +  +  L  LLLS N L  LP+ +G L  L+ L V  NRL  +  A+G    L
Sbjct: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291

Query: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
             L L++NLL  LP  +G L  L  LN+  N L++LP  + G  +L +L L  N LA +P
Sbjct: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351

Query: 257 ADLARLPLLTRLDLRDNQLRDLP 279
            +LA    L  LD+  N+L+ LP
Sbjct: 352 PELAHTTELHVLDVAGNRLQSLP 374



 Score =  106 bits (265), Expect = 9e-23
 Identities = 69/171 (40%), Positives = 95/171 (55%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L+ LP G + L  LAHL L+  SL+ LP  V  +  L  L L  N L  LP +L  L  L
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L +  N L+ LP  LGAL  L+ L L +N L  LPPE+G L  L+ L+++ NRL+ LP
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
           A L GL  L  L+L  NLL  +P  + +L  L+ L +  N+L ++   + D
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287



 Score =  103 bits (258), Expect = 6e-22
 Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)

Query: 28  RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75
           R+L  L  N +SL   PG    L +L   +  +            L+++E L L  + D 
Sbjct: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186

Query: 76  QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124
           ++L  TL  LP     LR L L            G  RR          L  LPA L GL
Sbjct: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242

Query: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
             L  L LS N L  LP  + Q++ L  L +  N L E+ EA+G    L+ L +T N L 
Sbjct: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302

Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
            LP +LG L+ L  L++ +N L+ LPPEIGG  +L  L+L  NRL  LP  LA    L +
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362

Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278
           L +  N L S+P  L  L  L  L L +NQ + +
Sbjct: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)

Query: 59  LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
           LQ +  E  R S   +  LL+A  L +LP+    L +L   G    +         +  L
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74

Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
           P  ++    L  LD+S N +  +P  +   + L     S N LS LP+    L +L  L 
Sbjct: 75  PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134

Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
           +    LQ LP  +G L+ L  L+L +NLL +LP  +  L  L +L+L  N L+ LP +L 
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194

Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            L +LR L L  N L+++P +L  L  L  LD+ +N+L +LP EL
Sbjct: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)

Query: 59  LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118
           L+ L   F RL       L +  + +LP  ++    LV     R D         +  +P
Sbjct: 48  LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98

Query: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
             +     L   D S N L  LP    Q+R L  L L+   L  LP  +G L  L  L +
Sbjct: 99  ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158

Query: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
             N L++LP +L  L  L++LDL  N L+ LP  +G L +L EL L  N+L +LP  L  
Sbjct: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218

Query: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
           LR L  L +  N L  +PA+L  L LLT L L  N LR LP
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)

Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
           L  L L  N L  LP    ++  L  L LS N +  LP  +     L  L V+ N +  +
Sbjct: 38  LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97

Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
           P ++     L+  D S N L  LP     L SL  L L    LQ+LP  +  L +L  L 
Sbjct: 98  PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157

Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301
           L  NLL S+PA L+ L  L +LDL  N L  LP  L   P +R   L  N L    P+
Sbjct: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score =  112 bits (279), Expect = 2e-24
 Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)

Query: 44  PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95
           P G  QLL+L         L+ L   F RL+  +  +L E  L  LP++++ L  L    
Sbjct: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190

Query: 96  -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142
                      VL+   G +   + A     LT +P  +  L  L +LD+S N++E +  
Sbjct: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247

Query: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202
            +     L  LLLS N L +LPE +G+L  +T L +  N+L  LP ++G L +++ LD S
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307

Query: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262
            N ++ LP  IG L +L       N LQ LP  +   +++ +L LHSN L ++P ++  +
Sbjct: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367

Query: 263 PLLTRLDLRDNQLRDLP 279
             L  ++L DN+L++LP
Sbjct: 368 QKLKVINLSDNRLKNLP 384



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 55/169 (32%), Positives = 85/169 (50%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L  LP  ++ L  L  LDL  N    +P  + Q+ GL    +  N L+ +P  +G+L  L
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T+L V+ N ++ +   +     LQ L LS N L  LP  IG L ++  L +  N+L  LP
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            S+ GL S+  L    N + ++P+ + +L  L       N L+ LPPE+
Sbjct: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 54/162 (33%), Positives = 81/162 (50%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT LPA ++ L +L  LD+S N ++  P  +   + L  +  S N +S+LP+    L  L
Sbjct: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T L +    L+ LP   G L+ LQ L+L +N L  LP  +  L  L  L+L SN    +P
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
             L  L  L+   + +N L  +P  +  L  LT LD+  N +
Sbjct: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 53/169 (31%), Positives = 83/169 (49%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           ++ LP G S L +L  L L+   LE LPA   ++  L  L L  N L  LP+ +  L  L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L +  N    +P  L  LS L+   +  N L  +P  IG L  L  L+++ N ++ + 
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
             ++   +L+ L+L SN L  +P  +  L  +T L + +NQL  LP  +
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 54/166 (32%), Positives = 74/166 (44%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           +  LP  L     L  L L  N L TLPA +  +  L  L +S N + E PE +     L
Sbjct: 58  IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T +  + N +  LP     L  L +L L+   L+ LP   G L  L  L L  N+L+ LP
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
            ++  L  L  L L SN    VP  L +L  L    +  N+L  +P
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 51/156 (32%), Positives = 74/156 (47%)

Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
           L  L L  N +E LP  +   + L  L L  N L+ LP ++  L  L  L V+ N +Q  
Sbjct: 48  LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107

Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
           P  +     L  ++ S N +  LP     L +L +L L    L+ LPA+   L  L++L 
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167

Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           L  N L  +P  + RL  L RLDL  N+  ++P  L
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)

Query: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
           G    +T L  +H  L+ +P  +     TL+ L L  N ++ LP ++    SL +L+L  
Sbjct: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78

Query: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
           N L +LPAS+A L +LR L +  N +   P ++    +LT ++   N +  LP
Sbjct: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249
           G   T+  LD S   L+ +P EI      LE L L +N+++ LP  L   +SL  L L  
Sbjct: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78

Query: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           N L ++PA +A L  L  LD+  N +++ P  +
Sbjct: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111


>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score =  112 bits (279), Expect = 2e-24
 Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)

Query: 44  PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95
           P G  QLL+L         L+ L   F RL+  +  +L E  L  LP++++ L  L    
Sbjct: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190

Query: 96  -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142
                      VL+   G +   + A     LT +P  +  L  L +LD+S N++E +  
Sbjct: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247

Query: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202
            +     L  LLLS N L +LPE +G+L  +T L +  N+L  LP ++G L +++ LD S
Sbjct: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307

Query: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262
            N ++ LP  IG L +L       N LQ LP  +   +++ +L LHSN L ++P ++  +
Sbjct: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367

Query: 263 PLLTRLDLRDNQLRDLP 279
             L  ++L DN+L++LP
Sbjct: 368 QKLKVINLSDNRLKNLP 384



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 55/169 (32%), Positives = 85/169 (50%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L  LP  ++ L  L  LDL  N    +P  + Q+ GL    +  N L+ +P  +G+L  L
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T+L V+ N ++ +   +     LQ L LS N L  LP  IG L ++  L +  N+L  LP
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            S+ GL S+  L    N + ++P+ + +L  L       N L+ LPPE+
Sbjct: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 54/162 (33%), Positives = 81/162 (50%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT LPA ++ L +L  LD+S N ++  P  +   + L  +  S N +S+LP+    L  L
Sbjct: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T L +    L+ LP   G L+ LQ L+L +N L  LP  +  L  L  L+L SN    +P
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
             L  L  L+   + +N L  +P  +  L  LT LD+  N +
Sbjct: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 53/169 (31%), Positives = 83/169 (49%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           ++ LP G S L +L  L L+   LE LPA   ++  L  L L  N L  LP+ +  L  L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L +  N    +P  L  LS L+   +  N L  +P  IG L  L  L+++ N ++ + 
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
             ++   +L+ L+L SN L  +P  +  L  +T L + +NQL  LP  +
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 54/166 (32%), Positives = 74/166 (44%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           +  LP  L     L  L L  N L TLPA +  +  L  L +S N + E PE +     L
Sbjct: 58  IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T +  + N +  LP     L  L +L L+   L+ LP   G L  L  L L  N+L+ LP
Sbjct: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
            ++  L  L  L L SN    VP  L +L  L    +  N+L  +P
Sbjct: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 51/156 (32%), Positives = 74/156 (47%)

Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
           L  L L  N +E LP  +   + L  L L  N L+ LP ++  L  L  L V+ N +Q  
Sbjct: 48  LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107

Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
           P  +     L  ++ S N +  LP     L +L +L L    L+ LPA+   L  L++L 
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167

Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           L  N L  +P  + RL  L RLDL  N+  ++P  L
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)

Query: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
           G    +T L  +H  L+ +P  +     TL+ L L  N ++ LP ++    SL +L+L  
Sbjct: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78

Query: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
           N L +LPAS+A L +LR L +  N +   P ++    +LT ++   N +  LP
Sbjct: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249
           G   T+  LD S   L+ +P EI      LE L L +N+++ LP  L   +SL  L L  
Sbjct: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78

Query: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           N L ++PA +A L  L  LD+  N +++ P  +
Sbjct: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score =  111 bits (277), Expect = 3e-24
 Identities = 80/221 (36%), Positives = 112/221 (50%), Gaps = 14/221 (6%)

Query: 76  QLLEATLAQLPQSLSCLRSLV-LKGGQRR-----DTLGACLR--------GALTNLPAGL 121
           +L E  L  LP SL+ LR L  L  G        +++GA L           L+ LP  +
Sbjct: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216

Query: 122 SGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
             L +L  LD+S N LE LP  +  +  L  L++S N L  +P+ +G L  L+ L V  N
Sbjct: 217 GNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN 276

Query: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
           RL  LP A+G   +L  L L++N L TLP  IG L  L  LN   N+L SLP  + G  S
Sbjct: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336

Query: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           L +  +  N L  +PA++++   L  LD+  N+L  LP  L
Sbjct: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377



 Score =  109 bits (272), Expect = 1e-23
 Identities = 80/225 (35%), Positives = 114/225 (50%), Gaps = 9/225 (4%)

Query: 58  PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
           PL  L   F  L       + + +L  LP+++  L +L     + R+ L       LT L
Sbjct: 116 PLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL--ELRENL-------LTYL 166

Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
           P  L+ L  L  LDL  N +  LP  +  +  L  L L  N LSELP+ +G L  L  L 
Sbjct: 167 PDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLD 226

Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
           V+ NRL+ LP  +  L++L  L +SQNLL+T+P  IG L  L  L +  NRL  LP ++ 
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVG 286

Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
              SL  LVL  N L ++P  + +L  L+ L+   N+L  LP E+
Sbjct: 287 ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331



 Score =  106 bits (264), Expect = 1e-22
 Identities = 78/228 (34%), Positives = 113/228 (49%), Gaps = 16/228 (7%)

Query: 82  LAQLPQSLSCLRSLVLKGGQRRDTLGACL---RGALTNLPAGLSGLAHLAHLDLSFNSLE 138
           L++LPQ +  L++L+            CL      L  LP  +SGL  L  L +S N LE
Sbjct: 209 LSELPQEIGNLKNLL------------CLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256

Query: 139 TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQR 198
           T+P  + +++ L  L +  N L++LPEA+G   +LT L +T N+L TLP ++G L  L  
Sbjct: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316

Query: 199 LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPAD 258
           L+  +N L +LP EIGG  SL    +  NRL  +PA ++    L +L +  N L  +P  
Sbjct: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLS 376

Query: 259 LARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSP 306
           L  L  L  L L DNQ + L     D  +   +        P  PS P
Sbjct: 377 LTALK-LKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEP 423



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 59/169 (34%), Positives = 89/169 (52%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           +  LP  ++    L  LD+S N +  +P  +   + L     S N L+ LPE+   L  L
Sbjct: 71  IQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T L+V    LQ+LP  +G L  L  L+L +NLL  LP  +  L  L EL+L +N + +LP
Sbjct: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            S+  L  L+ L L  N L+ +P ++  L  L  LD+ +N+L  LP E+
Sbjct: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEI 239



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 74/247 (29%), Positives = 111/247 (44%), Gaps = 40/247 (16%)

Query: 56  QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALT 115
           +Q  QL+++  L LS +E        + +LP  ++    LV     R +         + 
Sbjct: 53  EQFFQLVKLRKLGLSDNE--------IQRLPPEIANFMQLVELDVSRNE---------IP 95

Query: 116 NLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTF 175
            +P  +S    L   D S N L  LP    +++ L  L ++   L  LPE +G L  L  
Sbjct: 96  EIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLAS 155

Query: 176 LTVTHNRLQTLPPALGALSTLQRLDLSQ-----------------------NLLDTLPPE 212
           L +  N L  LP +L  L  L+ LDL                         N L  LP E
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215

Query: 213 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 272
           IG L +LL L+++ NRL+ LP  ++GL SL  LV+  NLL ++P  + +L  L+ L +  
Sbjct: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQ 275

Query: 273 NQLRDLP 279
           N+L  LP
Sbjct: 276 NRLTQLP 282



 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 59/169 (34%), Positives = 80/169 (47%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L  LP     L  L  L LS N ++ LP  +     L  L +S N + E+PE++    AL
Sbjct: 48  LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKAL 107

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
                + N L  LP +   L  L  L ++   L +LP  IG L +L  L L  N L  LP
Sbjct: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            SL  LR L  L L +N + ++P  +  L  L  L L  NQL +LP E+
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 60/174 (34%), Positives = 81/174 (46%), Gaps = 3/174 (1%)

Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
           L  L L  N L  LP    Q+  L  L LS N +  LP  +     L  L V+ N +  +
Sbjct: 38  LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97

Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
           P ++     LQ  D S N L  LP     L +L  L++    LQSLP ++  L +L  L 
Sbjct: 98  PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157

Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPE---LLDAPFVRLQGNPLGE 297
           L  NLL  +P  L +L  L  LDL +N++ +LP     LL    + L GN L E
Sbjct: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSE 211



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 1/158 (0%)

Query: 126 HLAHLDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
           H+  +D    SL  +P  + +  R L  LLL  N L ELPE    L  L  L ++ N +Q
Sbjct: 13  HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72

Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
            LPP +     L  LD+S+N +  +P  I    +L   + + N L  LP S   L++L  
Sbjct: 73  RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132

Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           L ++   L S+P ++  L  L  L+LR+N L  LP  L
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL 170


>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
          Length = 371

 Score =  110 bits (274), Expect = 8e-24
 Identities = 91/250 (36%), Positives = 122/250 (48%), Gaps = 44/250 (17%)

Query: 79  EATLAQLPQSLSCLRS-LVLKGGQRRDTLGACLR-----GALTNLPAGL-SGLAHLAHLD 131
           E   ++L  S   L S L  +G +RR    A LR       L +LP  L SG  HL  LD
Sbjct: 15  ELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLD 74

Query: 132 LSFNSLETLPACVLQMRGLGALL-----------------------------LSHNCLSE 162
           +S N+L  L   +L +RGL  LL                             LS NC  E
Sbjct: 75  VSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQE 134

Query: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
           +P +L  L AL  L++  N+LQ++P  +  L +L+ L L  N +  +PPE+G L SL  L
Sbjct: 135 VPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYL 194

Query: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL-----RD 277
            L  N++QS+P  L+ L SLR L LH+NLL  +P ++  L  L  L LR N L     RD
Sbjct: 195 VLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRD 254

Query: 278 L---PPELLD 284
           L   PP LL+
Sbjct: 255 LTYDPPTLLE 264



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 68/171 (39%), Positives = 88/171 (51%), Gaps = 12/171 (7%)

Query: 128 AHLDLSFNSLET-LPACVLQMRG----LGALLLSHNCLSELPEALGA-LPALTFLTVTHN 181
           + L +S  +LE+ L A   + RG    L  LLL HN L  LP ALG+  P L  L V+ N
Sbjct: 19  SRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGN 78

Query: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------SLLELNLASNRLQSLPAS 235
            L  L P L AL  L+ L    N L        GL       SL  LNL+ N  Q +PAS
Sbjct: 79  ALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPAS 138

Query: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
           L  LR+L+ L L  N L S+PA++  L  L  L L  N ++++PPEL + P
Sbjct: 139 LLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189


>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
          Length = 1537

 Score =  109 bits (273), Expect = 1e-23
 Identities = 103/317 (32%), Positives = 147/317 (46%), Gaps = 31/317 (9%)

Query: 44  PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL--VL 97
           P G  QLL+L         L+ L   F RL      +L E  L  LP+S+  L  L  + 
Sbjct: 131 PDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLD 190

Query: 98  KGGQRRDTLGACL------------RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL 145
            G      L   L              AL  LP  +  L  L +LD+S N +ET+   + 
Sbjct: 191 LGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS 250

Query: 146 QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNL 205
               L  LLLS N L +LP+++G L  LT L V  N+L  LP  +G LS L+  D S N 
Sbjct: 251 GCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNE 310

Query: 206 LDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
           L++LP  IG L SL  L +  N L  LP  +   +++ ++ L SN L  +P ++ ++  L
Sbjct: 311 LESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKL 370

Query: 266 TRLDLRDNQLRDLP---PELLDAPFVRLQGN------PL-GEASPDAPSSPVA-ALIPEM 314
             L+L DN+L++LP    +L +   + L  N      PL  EA P+     +   + P+ 
Sbjct: 371 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQ 430

Query: 315 PR--LFLTSDLDSFPVT 329
           PR      SD DSF  T
Sbjct: 431 PRGDEDFQSDSDSFNPT 447



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 68/234 (29%), Positives = 111/234 (47%), Gaps = 10/234 (4%)

Query: 47  CQQLLHLCV-QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
           CQ L  L +    L  L      L   ++  + +  + + P+++ C + L         T
Sbjct: 68  CQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL---------T 118

Query: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
           +       ++ LP G + L +L  L L+   LE LPA   ++  L  L L  N L  LP+
Sbjct: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178

Query: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLA 225
           ++  L  L  L + +N    LP  L  +  L+ L +  N L  LP  IG L  L+ L+++
Sbjct: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS 238

Query: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
            NR++++   ++G  +L  L+L SN+L  +P  +  L  LT L + DNQL  LP
Sbjct: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 53/169 (31%), Positives = 89/169 (52%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L+NLP  ++ L +L  LD+S N ++  P  +   + L  +  S N +S+LP+    L  L
Sbjct: 81  LSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNL 140

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T L +    L+ LP   G L  L+ L+L +N L TLP  +  L  L  L+L +N    LP
Sbjct: 141 TQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELP 200

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
             L  +++LR L + +N L  +P  + +L +L  LD+  N++  +  ++
Sbjct: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDI 249



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 53/158 (33%), Positives = 79/158 (50%), Gaps = 1/158 (0%)

Query: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
           L  L L  N +E LP  +   + L  L +  N LS LP  + +L  L  L ++ N +Q  
Sbjct: 48  LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107

Query: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
           P  +     L  ++ S N +  LP     L +L +L L    L+ LPA+   L  LR+L 
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167

Query: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
           L  N L ++P  + +L  L RLDL +N+  +L PE+LD
Sbjct: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGEL-PEVLD 204



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 52/154 (33%), Positives = 75/154 (48%), Gaps = 1/154 (0%)

Query: 130 LDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPP 188
           LD S  SL+ +P  V    R L  L L  N + ELP+ L    AL  L++  N L  LP 
Sbjct: 27  LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86

Query: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
            + +L  L+ LD+S+N +   P  I     L  +  + N +  LP     L +L  L L+
Sbjct: 87  TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146

Query: 249 SNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
              L  +PA+  RL  L  L+LR+N L+ LP  +
Sbjct: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 51/166 (30%), Positives = 74/166 (44%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           +  LP  L     L  L +  N L  LP  +  +  L  L +S N + E PE +     L
Sbjct: 58  IEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL 117

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
           T +  + N +  LP     L  L +L L+   L+ LP   G L  L  L L  N L++LP
Sbjct: 118 TIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLP 177

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
            S+  L  L  L L +N    +P  L ++  L  L + +N L+ LP
Sbjct: 178 KSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score =  108 bits (270), Expect = 2e-23
 Identities = 80/229 (34%), Positives = 122/229 (53%), Gaps = 13/229 (5%)

Query: 58  PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
           P Q+ ++  L+        LL A L QLP +++ L++L L+  QR  +          NL
Sbjct: 167 PPQMRRLVHLQTLVLNGNPLLHAQLRQLP-AMTALQTLHLRSTQRTQS----------NL 215

Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
           P  L GL++LA +DLS N L  +P C+  +  L  L LS N ++EL   +     +  L 
Sbjct: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLN 275

Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPAS 235
           ++ N+L +LP A+  LS L++L L+ N L  D LP  IG L +L E   A+N L+ +P S
Sbjct: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES 335

Query: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
           L     LR LVL+ N L ++P  +  L  +  LD+R+N    +PP+  D
Sbjct: 336 LCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 98/332 (29%), Positives = 147/332 (44%), Gaps = 33/332 (9%)

Query: 5   VEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQV 64
           V G +L      G    ++     +L +L  NR  L   P        L   Q L+ L V
Sbjct: 10  VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPE------ELAALQKLEHLSV 63

Query: 65  EFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGL 124
               L+T      L   L+ LP     LR++V +    +++           +P  +  L
Sbjct: 64  SHNNLTT------LHGELSSLPS----LRAIVARANSLKNS----------GVPDDIFKL 103

Query: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA-LPALTFLTVTHNRL 183
             L+ LDLS N L   P  +   + +  L LSHN +  +P  L   L  L +L ++ NRL
Sbjct: 104 DDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRL 163

Query: 184 QTLPPALGALSTLQRLDLSQN-LLDTLPPEIGGLGSLLELNLAS-NRLQS-LPASLAGLR 240
           ++LPP +  L  LQ L L+ N LL     ++  + +L  L+L S  R QS LP SL GL 
Sbjct: 164 ESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLS 223

Query: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
           +L  + L  N L  VP  L  LP L RL+L  NQ+ +L   L    +V ++   L     
Sbjct: 224 NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITEL--SLCIDQWVHVETLNLSRNQL 281

Query: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQG 332
            +  S +  L  ++ +L+L S+   F   P G
Sbjct: 282 TSLPSAICKL-SKLKKLYLNSNKLDFDGLPSG 312



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 44/125 (35%), Positives = 70/125 (56%), Gaps = 4/125 (3%)

Query: 165 EALGALPALTFLTVTHNRLQT--LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
           EA G LP +  + ++ N  +    P  + A+++L+ L L++  L  LP E+  L  L  L
Sbjct: 2   EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHL 61

Query: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLL--ASVPADLARLPLLTRLDLRDNQLRDLPP 280
           +++ N L +L   L+ L SLR +V  +N L  + VP D+ +L  L+ LDL  NQL + P 
Sbjct: 62  SVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121

Query: 281 ELLDA 285
           EL +A
Sbjct: 122 ELENA 126


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score =  108 bits (270), Expect = 2e-23
 Identities = 78/250 (31%), Positives = 124/250 (49%), Gaps = 21/250 (8%)

Query: 36  NRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL 95
           N + LDL     ++ +H+      +L Q+  L L +++        L  LP  + CL +L
Sbjct: 101 NSMRLDL----SKRSIHILPSSIKELTQLTELYLYSNK--------LQSLPAEVGCLVNL 148

Query: 96  VLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLL 155
           +        TL A    +LT+LP  L  L  L  LDL  N L  +P+ V ++  L  L L
Sbjct: 149 M--------TL-ALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYL 199

Query: 156 SHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGG 215
             N ++ + + +  L  L+ L++  N+++ LP  +G L  L  LD++ N L+ LP EIG 
Sbjct: 200 RFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259

Query: 216 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
              +  L+L  N L  LP ++  L SL  L L  N L+++P  LA+   L  L+L +N +
Sbjct: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319

Query: 276 RDLPPELLDA 285
             LP  LL +
Sbjct: 320 STLPESLLSS 329



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 65/186 (34%), Positives = 97/186 (52%), Gaps = 7/186 (3%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT+LP        +  L+L+ N L  +P  V  +  L  L+LS+N L +LP  LG L  L
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL 450

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L +  N+L++LP  +  L  LQ+L L+ N L TLP  IG L +L  L L  N L  LP
Sbjct: 451 RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLP 510

Query: 234 ASLAGLRSLRLLVLHSNL-LASVPADLARLPLLTRLDLRDNQLRDLPPELLDA------P 286
             +  L +L  L L+ N  L S+P +LA    L+ + + +  L  LPP+++         
Sbjct: 511 EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQ 570

Query: 287 FVRLQG 292
           F+++QG
Sbjct: 571 FLKMQG 576



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 62/171 (36%), Positives = 93/171 (54%), Gaps = 2/171 (1%)

Query: 114 LTNLPAGLSGLAH-LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPA 172
           +  +P G+   A  L+ L++  N L +LP        +  L L+ N L+++PE +  L +
Sbjct: 367 INKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVS 426

Query: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 232
           L  L +++N L+ LP  LG L  L+ LDL +N L++LP EI  L  L +L L +N+L +L
Sbjct: 427 LEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTL 486

Query: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN-QLRDLPPEL 282
           P  +  L +L  L L  NLL  +P ++  L  L  L L DN  L  LP EL
Sbjct: 487 PRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFEL 537


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score =  108 bits (270), Expect = 2e-23
 Identities = 68/166 (40%), Positives = 94/166 (56%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L +L   L  L  L  LD+  N L +LP+ + ++  L  L +SHN L  LPE +  L  L
Sbjct: 94  LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNL 153

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L + HN L  +      LS L+ LDLS N L T+P     L SL+ LNL+SN L+SLP
Sbjct: 154 KCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLP 213

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
           A +  ++ L+ L  +SNLL ++P +LA +  L  L LR N+LR LP
Sbjct: 214 AEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 66/192 (34%), Positives = 95/192 (49%), Gaps = 24/192 (12%)

Query: 115 TNLPAGLSGLAHLA-HLDLSFNSLETLPACVLQMR-----------------------GL 150
           T++P GL   A  +  L+LS  +L  +P CV ++                         L
Sbjct: 25  TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDL 84

Query: 151 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 210
             L++S+N L  L + L  LPALT L +  N+L +LP A+  L  LQ+L++S N L  LP
Sbjct: 85  TKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILP 144

Query: 211 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 270
            EI  L +L  L L  N L  +      L +L  L L +N L +VPA  + L  L RL+L
Sbjct: 145 EEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNL 204

Query: 271 RDNQLRDLPPEL 282
             N+L+ LP E+
Sbjct: 205 SSNELKSLPAEI 216



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 65/197 (32%), Positives = 103/197 (52%), Gaps = 3/197 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT +PA  S L+ L  L+LS N L++LPA + +M+ L  L  + N L  +P  L  + +L
Sbjct: 186 LTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSL 232
             L +  N+L+ LP    + S L+ L + +N ++ L  E +  L S+L L+L  N+L+S+
Sbjct: 246 ELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304

Query: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQG 292
           P  +  LRSL  L L +N ++S+P  L  L  L  L L  N LR +  E++      +  
Sbjct: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363

Query: 293 NPLGEASPDAPSSPVAA 309
               +   D PS   +A
Sbjct: 364 YLRSKIKDDGPSQSESA 380



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 70/195 (35%), Positives = 98/195 (50%), Gaps = 12/195 (6%)

Query: 66  FLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLA 125
           F +LS  ED  L    L  +P S S L SLV      R  L +     L +LPA ++ + 
Sbjct: 170 FEQLSNLEDLDLSNNHLTTVPASFSSLSSLV------RLNLSS---NELKSLPAEINRMK 220

Query: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
            L HLD + N LET+P  +  M  L  L L  N L  LPE   +   L  L V  N+++ 
Sbjct: 221 RLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEM 279

Query: 186 LPPA-LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
           L    L  L+++  LDL  N L ++P EI  L SL  L+L++N + SLP SL  L  L+ 
Sbjct: 280 LEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKF 338

Query: 245 LVLHSNLLASVPADL 259
           L L  N L ++  ++
Sbjct: 339 LALEGNPLRTIRREI 353



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 49/144 (34%), Positives = 78/144 (54%), Gaps = 5/144 (3%)

Query: 156 SHNCLSELPEALGALPALTF-LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 214
           S N L E+P+ +  L  +   + ++ N+L  +   L  L  L  LDL  N L++LP E+ 
Sbjct: 433 SKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEME 492

Query: 215 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASV-PADLARLPLLTRLDLRDN 273
            L  L  +NL+ NR + LP  L  + +L  +++ +N + SV P  +  +  LT LDL++N
Sbjct: 493 SLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNN 552

Query: 274 QLRDLPPELLDAPFVR---LQGNP 294
            L  +PPEL +   +R   L GNP
Sbjct: 553 DLLQIPPELGNCVNLRTLLLDGNP 576



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 43/127 (33%), Positives = 71/127 (55%), Gaps = 5/127 (3%)

Query: 127 LAHLDLSFNSLE--TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
           ++ +DLSFN L   +L  CVLQ   L  L L +N L+ LPE + +L  L  + ++ NR +
Sbjct: 451 VSDVDLSFNKLSFISLELCVLQK--LTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK 508

Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
            LP  L  + TL+ + +S N + ++ P+ +  + +L  L+L +N L  +P  L    +LR
Sbjct: 509 MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568

Query: 244 LLVLHSN 250
            L+L  N
Sbjct: 569 TLLLDGN 575



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 34/105 (32%), Positives = 52/105 (49%), Gaps = 1/105 (0%)

Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
           L  L  LDL  N L +LP  +  +  L  + LS N    LPE L  +  L  + +++N++
Sbjct: 471 LQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530

Query: 184 QTL-PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
            ++ P  +  +  L  LDL  N L  +PPE+G   +L  L L  N
Sbjct: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 29/92 (31%), Positives = 49/92 (53%), Gaps = 1/92 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSEL-PEALGALPA 172
           L +LP  +  L  L  ++LSFN  + LP  + ++  L  +L+S+N +  + P+ +  +  
Sbjct: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543

Query: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
           LT L + +N L  +PP LG    L+ L L  N
Sbjct: 544 LTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575


>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
           sapiens]
          Length = 796

 Score =  105 bits (262), Expect = 2e-22
 Identities = 80/217 (36%), Positives = 111/217 (51%), Gaps = 16/217 (7%)

Query: 68  RLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHL 127
           RLS H D   L A           L SL      R   L AC    L  +P  +  L  L
Sbjct: 562 RLSLHNDGARLVA-----------LNSLKKLAALRELELVAC---GLERIPHAVFSLGAL 607

Query: 128 AHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
             LDL  N L ++   +     R L  L L HN ++ +PE +  L +L  L +++N+L+T
Sbjct: 608 QELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLET 667

Query: 186 LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLL 245
           LP  LG  S L+ LD+S N L +LPPE+G L +L  L L+ N L++LP  L   R LR L
Sbjct: 668 LPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTL 727

Query: 246 VLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           +L  N L+ +   +  L  L+RL+L+ N+L  LP EL
Sbjct: 728 LLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEEL 764



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 68/211 (32%), Positives = 99/211 (46%), Gaps = 20/211 (9%)

Query: 68  RLSTHEDPQLLEATLAQLPQ---SLSCLRSLVLKGGQRRD-----TLGACLR-------- 111
           +L+   + +L+   L ++P    SL  L+ L LK    R      +   C +        
Sbjct: 580 KLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWH 639

Query: 112 GALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
             +  +P  +  L  L  L LS+N LETLP+ +    GL  L +SHN L  LP  +G L 
Sbjct: 640 NQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQ 699

Query: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
            L  L +++N L+ LP  L     L+ L L  N L  L P +G L +L  L L  NRL++
Sbjct: 700 NLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEA 759

Query: 232 LPASL---AGLRSLRLLVLHSNLLASVPADL 259
           LP  L    GL+   LLV    L   +PA++
Sbjct: 760 LPEELGNCGGLKKAGLLV-EDTLYQGLPAEV 789



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 62/220 (28%), Positives = 84/220 (38%), Gaps = 55/220 (25%)

Query: 118 PAGLSGLAHLAHLDL------------------------SFNSLETLPACVLQMRGLGAL 153
           P GLS L HL  L L                            L  +P  V  +RGL  L
Sbjct: 453 PPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEEL 512

Query: 154 LLSHNCLSELP-----EALGALPALTFLTVTHN-------------RLQTLP-------- 187
            L      EL      E+L  L  L  L++  N              LQ L         
Sbjct: 513 HLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARL 572

Query: 188 ---PALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP--ASLAGLRSL 242
               +L  L+ L+ L+L    L+ +P  +  LG+L EL+L  N L+S+    S    R L
Sbjct: 573 VALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKL 632

Query: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
             L L  N +A VP  + +L  L +L L  N+L  LP +L
Sbjct: 633 VTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQL 672


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score =  102 bits (254), Expect = 2e-21
 Identities = 82/202 (40%), Positives = 101/202 (50%), Gaps = 12/202 (5%)

Query: 78  LEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSL 137
           L A  A++  +L  LR L L   Q            L  LPA L  LAHL  LD+SFN L
Sbjct: 123 LTALGAEVVSALRELRKLNLSHNQ------------LPALPAQLGALAHLEELDVSFNRL 170

Query: 138 ETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQ 197
             LP  +  +  L  L + HN L+  P  L  L AL  L V+ NRL+ LP  + AL  L+
Sbjct: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALK 230

Query: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
            L LS   L TLP     L SL  L L +N LQ+LPA  + L+ L++L L SNL    PA
Sbjct: 231 ILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPA 290

Query: 258 DLARLPLLTRLDLRDNQLRDLP 279
            L  L  L  L L  NQL  +P
Sbjct: 291 ALLPLAGLEELYLSRNQLTSVP 312



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 70/185 (37%), Positives = 97/185 (52%), Gaps = 3/185 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           L +LP  LS L+ L  LD+  N L   P  +LQ+  L  L +S N L  LPE + AL AL
Sbjct: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRAL 229

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L ++   L TLP     L++L+ L L  N L  LP +   L  L  LNL+SN  +  P
Sbjct: 230 KILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFP 289

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---L 290
           A+L  L  L  L L  N L SVP+ ++ L  L  L L +N++R LP  +++   +    L
Sbjct: 290 AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVL 349

Query: 291 QGNPL 295
           QGN +
Sbjct: 350 QGNQI 354



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 80/239 (33%), Positives = 110/239 (46%), Gaps = 24/239 (10%)

Query: 82  LAQLPQSLSCL------------------RSLVLKGGQRRDTLGACLRGALTNLPAGLSG 123
           LA LP SLSCL                  + L L   +  D     LRG    LP  +S 
Sbjct: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRG----LPEDISA 225

Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
           L  L  L LS   L TLPA   ++  L +L+L +N L  LP     L  L  L ++ N  
Sbjct: 226 LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLF 285

Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
           +  P AL  L+ L+ L LS+N L ++P  I GLG LL L L +NR++ LP S+  L  L 
Sbjct: 286 EEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLE 345

Query: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPE--LLDAPFVRLQGNPLGEASP 300
            LVL  N +A +P    +L  +    ++DN L   P E  +   P++      L  + P
Sbjct: 346 ELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQP 404



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 83/239 (34%), Positives = 110/239 (46%), Gaps = 17/239 (7%)

Query: 58  PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQ--RRDTLGACLRGALT 115
           P  L  +E L L  +     LE     L  +L  LR LVL+  +  R     A L   LT
Sbjct: 59  PANLGDIEALNLGNNG----LEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLT 114

Query: 116 NLPAG-----------LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELP 164
            L              +S L  L  L+LS N L  LPA +  +  L  L +S N L+ LP
Sbjct: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP 174

Query: 165 EALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNL 224
           ++L  L  L  L V HN+L   P  L  L  L+ LD+S N L  LP +I  L +L  L L
Sbjct: 175 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234

Query: 225 ASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELL 283
           +   L +LPA    L SL  L+L +N L ++PA  + L  L  L+L  N   + P  LL
Sbjct: 235 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 69/224 (30%), Positives = 100/224 (44%), Gaps = 22/224 (9%)

Query: 56  QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLK--GGQRRDTL--GACLR 111
           +Q LQL+ +E L +S++         L  LP+ +S LR+L +    G    TL  G C  
Sbjct: 198 RQLLQLVALEELDVSSNR--------LRGLPEDISALRALKILWLSGAELGTLPAGFCEL 249

Query: 112 GALTNL----------PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLS 161
            +L +L          PA  S L  L  L+LS N  E  PA +L + GL  L LS N L+
Sbjct: 250 ASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLT 309

Query: 162 ELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE 221
            +P  +  L  L  L + +NR++ LP ++  L+ L+ L L  N +  LP   G L  +  
Sbjct: 310 SVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGL 369

Query: 222 LNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
             +  N L   P  +       +      L  S PA   RL LL
Sbjct: 370 WKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLL 413


>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
           sapiens]
          Length = 810

 Score =  100 bits (248), Expect = 8e-21
 Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)

Query: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
           +R  L  +P  +  L +L  +DL  N+L+T+   +    +  L  L L +N ++ +P  +
Sbjct: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658

Query: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
           G L  L  L +  N+++ +P  L     L+ LDLS N L  LP +IG L +L  L + +N
Sbjct: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718

Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
           R+++LP  L   R LR L L +N+L S+P+ +  L  LT+++LR N+L  LP EL + P 
Sbjct: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778

Query: 288 VRLQG 292
           ++  G
Sbjct: 779 LKRSG 783



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)

Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
           L  L  L L +N +  +P  +  +  L  L L+ N + ++P  L     L +L ++HN L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697

Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
             LP  +G L  LQ L ++ N ++TLPPE+     L  L+L +N LQSLP+ +  L +L 
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757

Query: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
            + L  N L  +P +L   PLL R  L + ++    LPPE+
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT LPA +  L +L +L ++ N +ETLP  + Q R L AL L +N L  LP  +G L  L
Sbjct: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756

Query: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
           T + +  NRL+ LP  LG    L+R  L + ++L +TLPPE+
Sbjct: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)

Query: 88  SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
           +L  LR  + K  Q +  L   +   L+ +P  +  L  L  L L      T+P  + Q+
Sbjct: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468

Query: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
            GL  L L H        AL  L   L  L +    ++ +P  + +L TL+ L L+ NL 
Sbjct: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528

Query: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
             +     I GL  L  L +    + L  LP  +  +              +L+VL+S  
Sbjct: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588

Query: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
              NL  L  +  DL R+P        L  +DL+DN L+ +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629


>gi|187829877 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  100 bits (248), Expect = 8e-21
 Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)

Query: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
           +R  L  +P  +  L +L  +DL  N+L+T+   +    +  L  L L +N ++ +P  +
Sbjct: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658

Query: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
           G L  L  L +  N+++ +P  L     L+ LDLS N L  LP +IG L +L  L + +N
Sbjct: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718

Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
           R+++LP  L   R LR L L +N+L S+P+ +  L  LT+++LR N+L  LP EL + P 
Sbjct: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778

Query: 288 VRLQG 292
           ++  G
Sbjct: 779 LKRSG 783



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)

Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
           L  L  L L +N +  +P  +  +  L  L L+ N + ++P  L     L +L ++HN L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697

Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
             LP  +G L  LQ L ++ N ++TLPPE+     L  L+L +N LQSLP+ +  L +L 
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757

Query: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
            + L  N L  +P +L   PLL R  L + ++    LPPE+
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT LPA +  L +L +L ++ N +ETLP  + Q R L AL L +N L  LP  +G L  L
Sbjct: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756

Query: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
           T + +  NRL+ LP  LG    L+R  L + ++L +TLPPE+
Sbjct: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)

Query: 88  SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
           +L  LR  + K  Q +  L   +   L+ +P  +  L  L  L L      T+P  + Q+
Sbjct: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468

Query: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
            GL  L L H        AL  L   L  L +    ++ +P  + +L TL+ L L+ NL 
Sbjct: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528

Query: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
             +     I GL  L  L +    + L  LP  +  +              +L+VL+S  
Sbjct: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588

Query: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
              NL  L  +  DL R+P        L  +DL+DN L+ +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629


>gi|187829871 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  100 bits (248), Expect = 8e-21
 Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)

Query: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
           +R  L  +P  +  L +L  +DL  N+L+T+   +    +  L  L L +N ++ +P  +
Sbjct: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658

Query: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
           G L  L  L +  N+++ +P  L     L+ LDLS N L  LP +IG L +L  L + +N
Sbjct: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718

Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
           R+++LP  L   R LR L L +N+L S+P+ +  L  LT+++LR N+L  LP EL + P 
Sbjct: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778

Query: 288 VRLQG 292
           ++  G
Sbjct: 779 LKRSG 783



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)

Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
           L  L  L L +N +  +P  +  +  L  L L+ N + ++P  L     L +L ++HN L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697

Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
             LP  +G L  LQ L ++ N ++TLPPE+     L  L+L +N LQSLP+ +  L +L 
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757

Query: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
            + L  N L  +P +L   PLL R  L + ++    LPPE+
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT LPA +  L +L +L ++ N +ETLP  + Q R L AL L +N L  LP  +G L  L
Sbjct: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756

Query: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
           T + +  NRL+ LP  LG    L+R  L + ++L +TLPPE+
Sbjct: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798



 Score = 37.7 bits (86), Expect = 0.049
 Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)

Query: 88  SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
           +L  LR  + K  Q +  L   +   L+ +P  +  L  L  L L      T+P  + Q+
Sbjct: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468

Query: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
            GL  L L H        AL  L   L  L +    ++ +P  + +L TL+ L L+ NL 
Sbjct: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528

Query: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
             +     I GL  L  L +    + L  LP  +  +              +L+VL+S  
Sbjct: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588

Query: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
              NL  L  +  DL R+P        L  +DL+DN L+ +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629


>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
          Length = 301

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 64/199 (32%), Positives = 107/199 (53%), Gaps = 2/199 (1%)

Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
           LP  +  L  +  L+L  N L++LP  V  ++ L  L ++ NCL+E+P  L     L  L
Sbjct: 86  LPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVL 145

Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
           +++HN L  LP     LS L++L+LS N    +P  +  L  L+ L++ SNRL+++  S+
Sbjct: 146 SLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESI 205

Query: 237 AGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL-LDAPFVRLQGNPL 295
             L SL++ +   N + S P  L  +  L  L+L +N ++ LP EL L    VR+  NP+
Sbjct: 206 QHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWNPM 265

Query: 296 GEASPDAPSSPVAALIPEM 314
            +       +P++  +PE+
Sbjct: 266 -DKGLHISHNPLSKPLPEL 283


>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
           containing 3 [Homo sapiens]
          Length = 712

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 70/187 (37%), Positives = 98/187 (52%), Gaps = 7/187 (3%)

Query: 114 LTNLPAGLSG--LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
           L   P G +   L      DLS N L  +P        L  L L  NC+  +PEA+  L 
Sbjct: 69  LREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQ 128

Query: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
           ALTFL ++ N+L TLP  L  L  L+ L  S N L +LP EIG L  L+EL+++ N +Q+
Sbjct: 129 ALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQT 187

Query: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFV 288
           +P+ +  L +LR L +  N L  +P +LA LPL+ RLD   N++  +P     L     +
Sbjct: 188 IPSQIGNLEALRDLNVRRNHLVHLPEELAELPLI-RLDFSCNKITTIPVCYRNLRHLQTI 246

Query: 289 RLQGNPL 295
            L  NPL
Sbjct: 247 TLDNNPL 253



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 62/180 (34%), Positives = 93/180 (51%), Gaps = 3/180 (1%)

Query: 104 DTLGACL-RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSE 162
           DT  A L R  L+ +P        L +L+L  N +  +P  +L ++ L  L +S N LS 
Sbjct: 83  DTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLST 142

Query: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
           LP  L  LP L  L  ++N+L +LP  +G L  L  LD+S N + T+P +IG L +L +L
Sbjct: 143 LPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDL 201

Query: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           N+  N L  LP  LA L  +R L    N + ++P     L  L  + L +N L+  P ++
Sbjct: 202 NVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260


>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
           sapiens]
          Length = 803

 Score = 96.7 bits (239), Expect = 9e-20
 Identities = 60/181 (33%), Positives = 98/181 (54%), Gaps = 2/181 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171
           L  +P  +  L  L  LDL  N+L+++   V    +R L  L L HN ++ +PE +  L 
Sbjct: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660

Query: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
           +L  L+ +HN+++ LP  L   + ++ LDLS N +  +PPEIG L SL   ++  N+++S
Sbjct: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720

Query: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291
           LP  L   + L+ L +  N L+ +   +  L  L+ LD++ N    LPPEL D   ++  
Sbjct: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA 780

Query: 292 G 292
           G
Sbjct: 781 G 781



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 49/174 (28%), Positives = 88/174 (50%), Gaps = 2/174 (1%)

Query: 88  SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
           +L  +  +V     R+ T+      ++T +P  +  L  L  L  S N +E LP+ +   
Sbjct: 623 NLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLC 682

Query: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
             +  L LS+N +  +P  +G L +L + ++T N++++LP  L     L+ L + +N L 
Sbjct: 683 NKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLS 742

Query: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL--LVLHSNLLASVPADL 259
            L P+IG L  L  L++  N  + LP  L   R+L+   LV+   L  ++P+D+
Sbjct: 743 VLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 7/87 (8%)

Query: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
           RL+L   +L  LP  +  +  L  L L   +   +PA++A L +L+ L LH     SV  
Sbjct: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQ---CSVKI 481

Query: 258 DLARLPLLTR----LDLRDNQLRDLPP 280
             A L  L      L ++ + +R+LPP
Sbjct: 482 HSAALSFLKENLKVLSVKFDDMRELPP 508


>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
          Length = 277

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 60/165 (36%), Positives = 89/165 (53%), Gaps = 2/165 (1%)

Query: 120 GLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVT 179
           GL  L+H+  L LS N L  +P  + +++ L  L   +N + ELP  + +L  L  L + 
Sbjct: 35  GLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 94

Query: 180 HNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
            NRL TLP   G+L  L+ LDL+ N L  ++LP     L +L  L L+ N  + LP  + 
Sbjct: 95  MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 154

Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            L  L++L L  N L S+P ++  L  L  L ++ N+L  LPPEL
Sbjct: 155 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 58/153 (37%), Positives = 82/153 (53%), Gaps = 2/153 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           LT +P  ++ L +L  L+   N +E LP  +  ++ L  L L  N L+ LP   G+LPAL
Sbjct: 52  LTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111

Query: 174 TFLTVTHNRLQ--TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
             L +T+N L   +LP     L+TL+ L LS N  + LPP+IG L  L  L+L  N L S
Sbjct: 112 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 171

Query: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPL 264
           LP  +  L  L+ L +  N L  +P +L  L L
Sbjct: 172 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204


>gi|197333692 leucine rich repeat containing 8 family, member B
           [Homo sapiens]
          Length = 803

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 80/255 (31%), Positives = 128/255 (50%), Gaps = 14/255 (5%)

Query: 41  DLYPGGC---QQLLHLCVQ--QPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC---- 91
           +LY  GC   +QL  + ++  Q L+ L+  +L+ S    PQ++   L  L Q LS     
Sbjct: 514 ELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL-QKLSLDNEG 572

Query: 92  LRSLVLKGGQRRDTLGAC--LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QM 147
            + +VL   ++   L +   +   L  +P  +  L +L  LDL  N+L+T+   +    +
Sbjct: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632

Query: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
           + L  L L HN ++ +P  +GAL  L  L++ HN ++ LP  L   + L  LDLS N L 
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692

Query: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
            +P EI  L +L    + +N ++ LP  L   + L+ L+L  N L ++   +  L  LT 
Sbjct: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTH 752

Query: 268 LDLRDNQLRDLPPEL 282
           L+L  N L  LPPEL
Sbjct: 753 LELIGNYLETLPPEL 767



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 7/154 (4%)

Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
           +PA +  L++L  L L  N++E LP  +     L  L LS+N L+ +PE +  L  L + 
Sbjct: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707

Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
            VT+N ++ LP  L     LQ L L +N L  L P +G L +L  L L  N L++LP  L
Sbjct: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767

Query: 237 AGLRSLR--LLVLHSNLLASVPADLARLPLLTRL 268
            G +SL+   L++  NLL ++P     LP+  RL
Sbjct: 768 EGCQSLKRNCLIVEENLLNTLP-----LPVTERL 796



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 2/122 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           + NLP  L     L +LDLS+N L  +P  +  +  L    +++N +  LP+ L     L
Sbjct: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE--LNLASNRLQS 231
             L +  N L  L P +G LS L  L+L  N L+TLPPE+ G  SL    L +  N L +
Sbjct: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNT 787

Query: 232 LP 233
           LP
Sbjct: 788 LP 789



 Score = 35.0 bits (79), Expect = 0.32
 Identities = 50/153 (32%), Positives = 70/153 (45%), Gaps = 11/153 (7%)

Query: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
           ++L    L  LP  V ++  +  L L      +LP A+  L  L  L V H+ L    PA
Sbjct: 422 IELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPA 481

Query: 190 LGAL-STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL--QSLPASLAG---LRSLR 243
           L  L   L+ L L    +  +P  +  L +L EL L+   L  Q     L G   L++LR
Sbjct: 482 LAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLR 541

Query: 244 LLVLHSNL--LASVPADLARLPLLTRLDLRDNQ 274
            L L S+L  +  V  DL  LP L +L L DN+
Sbjct: 542 TLYLKSSLSRIPQVVTDL--LPSLQKLSL-DNE 571


>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
           sapiens]
          Length = 803

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 80/255 (31%), Positives = 128/255 (50%), Gaps = 14/255 (5%)

Query: 41  DLYPGGC---QQLLHLCVQ--QPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC---- 91
           +LY  GC   +QL  + ++  Q L+ L+  +L+ S    PQ++   L  L Q LS     
Sbjct: 514 ELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL-QKLSLDNEG 572

Query: 92  LRSLVLKGGQRRDTLGAC--LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QM 147
            + +VL   ++   L +   +   L  +P  +  L +L  LDL  N+L+T+   +    +
Sbjct: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632

Query: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
           + L  L L HN ++ +P  +GAL  L  L++ HN ++ LP  L   + L  LDLS N L 
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692

Query: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
            +P EI  L +L    + +N ++ LP  L   + L+ L+L  N L ++   +  L  LT 
Sbjct: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTH 752

Query: 268 LDLRDNQLRDLPPEL 282
           L+L  N L  LPPEL
Sbjct: 753 LELIGNYLETLPPEL 767



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 7/154 (4%)

Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
           +PA +  L++L  L L  N++E LP  +     L  L LS+N L+ +PE +  L  L + 
Sbjct: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707

Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
            VT+N ++ LP  L     LQ L L +N L  L P +G L +L  L L  N L++LP  L
Sbjct: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767

Query: 237 AGLRSLR--LLVLHSNLLASVPADLARLPLLTRL 268
            G +SL+   L++  NLL ++P     LP+  RL
Sbjct: 768 EGCQSLKRNCLIVEENLLNTLP-----LPVTERL 796



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 2/122 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           + NLP  L     L +LDLS+N L  +P  +  +  L    +++N +  LP+ L     L
Sbjct: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE--LNLASNRLQS 231
             L +  N L  L P +G LS L  L+L  N L+TLPPE+ G  SL    L +  N L +
Sbjct: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNT 787

Query: 232 LP 233
           LP
Sbjct: 788 LP 789



 Score = 35.0 bits (79), Expect = 0.32
 Identities = 50/153 (32%), Positives = 70/153 (45%), Gaps = 11/153 (7%)

Query: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
           ++L    L  LP  V ++  +  L L      +LP A+  L  L  L V H+ L    PA
Sbjct: 422 IELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPA 481

Query: 190 LGAL-STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL--QSLPASLAG---LRSLR 243
           L  L   L+ L L    +  +P  +  L +L EL L+   L  Q     L G   L++LR
Sbjct: 482 LAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLR 541

Query: 244 LLVLHSNL--LASVPADLARLPLLTRLDLRDNQ 274
            L L S+L  +  V  DL  LP L +L L DN+
Sbjct: 542 TLYLKSSLSRIPQVVTDL--LPSLQKLSL-DNE 571


>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
          Length = 367

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 62/161 (38%), Positives = 90/161 (55%), Gaps = 1/161 (0%)

Query: 123 GLAHLAHLDLSFNSLETLPACVLQ-MRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
           GL +L  L +  NSL +LP  + Q +  L  L L  N +  +PEA+G+L  L  L ++ N
Sbjct: 39  GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98

Query: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
            L+ + P +G L  L+ L L+ N L  LPPE+G L  L  L++++NRL +LP  L    S
Sbjct: 99  ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158

Query: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           L+ L +  N L  VP  L +LP L  L +  N+L  LP +L
Sbjct: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 66/174 (37%), Positives = 91/174 (52%), Gaps = 2/174 (1%)

Query: 111 RGALTNLPAGLSG-LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
           R +LT+LP  L+  L +L  L L  N++  +P  +  +  L  L LS N L  +   +G 
Sbjct: 50  RNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGR 109

Query: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
           L AL  L + +N+LQ LPP +G L  LQ LD+S N L TLP  +    SL  L +  NRL
Sbjct: 110 LRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRL 169

Query: 230 QSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN-QLRDLPPEL 282
             +P  L  L SL  L +  N LA +P DL R   L  + + +N  L+ LP  L
Sbjct: 170 WYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 59/162 (36%), Positives = 87/162 (53%), Gaps = 4/162 (2%)

Query: 129 HLDLSFNSLETLPACVLQMRGLG---ALLLSHNCLSELPEALGA-LPALTFLTVTHNRLQ 184
           +L L++ +L   P  +L+  GL     L +  N L+ LPE L   LP L  L +  N + 
Sbjct: 19  NLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIV 78

Query: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
            +P A+G+L  LQ LDLS N L+ + PEIG L +L  L LA+N+LQ LP  +  L+ L+ 
Sbjct: 79  VVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQT 138

Query: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
           L + +N L ++P  L     L  L +  N+L  +P  L   P
Sbjct: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180


>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 58/166 (34%), Positives = 88/166 (53%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           + N P+ L  L +L  L L  N L  +P  +  ++ L  L L +N L+  P+AL  LP L
Sbjct: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKL 305

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L +T N + +LP  +  L  L+ L +  N L  L  EI  L  + EL LA N+L+ + 
Sbjct: 306 ISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
             +   R LR+L+L  NLL ++P  ++   +L  L L DN+L +LP
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 54/170 (31%), Positives = 86/170 (50%), Gaps = 1/170 (0%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL-QMRGLGALLLSHNCLSELPEALGALPA 172
           L   P  +  + ++ +L L  N ++T        + GL  L L  N LS LP  +  L  
Sbjct: 153 LQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHN 212

Query: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 232
           L  L V+HN +  +P  +  L  +++L    N ++  P ++  LG+L  L+L  N+L+ +
Sbjct: 213 LRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHI 272

Query: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           P +L  L++LR+L L  N L + P  L  LP L  LDL  N +  LP E+
Sbjct: 273 PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEI 322



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 53/182 (29%), Positives = 92/182 (50%), Gaps = 4/182 (2%)

Query: 98  KGGQRRDTLG----ACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGAL 153
           +G    D LG    +     L++LP+ +  L +L  L++S N +  +P  + Q+  +  L
Sbjct: 180 QGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL 239

Query: 154 LLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
              +N +   P  L  L  L  L++  N+L+ +P  L +L TL+ L+L  N L T P  +
Sbjct: 240 FFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL 299

Query: 214 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN 273
             L  L+ L+L  N + SLP  +  L++L  L++  N L  +  ++ +L  +  L L DN
Sbjct: 300 CFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADN 359

Query: 274 QL 275
           +L
Sbjct: 360 KL 361



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 50/169 (29%), Positives = 84/169 (49%), Gaps = 3/169 (1%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           ++ +P  +S    L HL+LS N L         +  L  L L  N + ++P ++  + +L
Sbjct: 499 ISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISL 558

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L +  N+ +T P  L  L  LQ LDLS+N L  +  +I  L  + +LN +SN+    P
Sbjct: 559 HVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFP 618

Query: 234 ASLAGLRSLRLL---VLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
             L  L+SL  L    +    L  +P +L+ +  L  LD+ +N +R++P
Sbjct: 619 IELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIP 667



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 61/215 (28%), Positives = 103/215 (47%), Gaps = 14/215 (6%)

Query: 82  LAQLPQSLSCLRSL-VLKGGQRR-----DTLGAC--LR------GALTNLPAGLSGLAHL 127
           +   P  L CL +L +L  G+ +     DTL +   LR        LT  P  L  L  L
Sbjct: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKL 305

Query: 128 AHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLP 187
             LDL+ N + +LP  + +++ L  LL+ HN L+ L   +  L  +  L +  N+L+ + 
Sbjct: 306 ISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365

Query: 188 PALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVL 247
             +     L+ L L +NLL  +P +I     L  L+L+ N+L  LP  +  L +LR L +
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425

Query: 248 HSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
           + N +  +   ++ L  +  L+   N + D+P E+
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEI 460



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 48/172 (27%), Positives = 88/172 (51%)

Query: 111 RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
           R  +  +   +S L ++  L+ S N +  +P  +   + +  + LS+N +   P  L AL
Sbjct: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL 486

Query: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ 230
            +L +L+V  N +  +P  +     L  L+LS+N L         L +L  L+L  N+++
Sbjct: 487 DSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIK 546

Query: 231 SLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            +PAS++ + SL +L+L  N   + P +L  L  L  LDL +NQL+ +  ++
Sbjct: 547 KIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDI 598



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 53/191 (27%), Positives = 92/191 (48%), Gaps = 6/191 (3%)

Query: 111 RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
           +  +  +PA +S +  L  L L  N  ET P  +  +  L  L LS N L ++   +  L
Sbjct: 542 KNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNL 601

Query: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQ---NLLDTLPPEIGGLGSLLELNLASN 227
             +  L  + N+    P  L  L +L++L++SQ     L  LP E+  +  L EL++++N
Sbjct: 602 KGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNN 661

Query: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPP---ELLD 284
            ++ +P ++  LR+L  L  ++N ++ +P  L  L  L +L+L  N L  LP     +  
Sbjct: 662 AIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFS 721

Query: 285 APFVRLQGNPL 295
              +    NPL
Sbjct: 722 LKEINFDDNPL 732



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 51/159 (32%), Positives = 80/159 (50%)

Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
           L  L  L L  N L +LP+ +  +  L  L +SHN +S +P+ +  L  +  L   +N +
Sbjct: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246

Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
           +  P  L  L  L+ L L +N L  +P  +  L +L  LNL  N+L + P +L  L  L 
Sbjct: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306

Query: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
            L L  NL++S+P ++  L  L  L +  N+L  L  E+
Sbjct: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEI 345



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 45/169 (26%), Positives = 82/169 (48%)

Query: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
           +T++P  +     +  ++LS+N +   P  +  +  L  L ++ N +SE+P  +     L
Sbjct: 453 ITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQL 512

Query: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
             L ++ N+L        +L  L+ LDL +N +  +P  I  + SL  L L  N+ ++ P
Sbjct: 513 LHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP 572

Query: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
             L  L +L++L L  N L  + +D+  L  + +L+   NQ    P EL
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIEL 621



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 66/274 (24%), Positives = 122/274 (44%), Gaps = 46/274 (16%)

Query: 39  SLDLYPGGCQQLLHLCVQQP----LQLLQVEFLRLSTHED-----PQLLEATL-----AQ 84
           +L++   G  +L H+    P    L++L +E+ +L+T        P+L+   L     + 
Sbjct: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317

Query: 85  LPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACV 144
           LP+ +  L++L        +TL       LT L   +  L  +  L L+ N LE +   +
Sbjct: 318 LPKEIRELKNL--------ETL-LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368

Query: 145 LQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQR------ 198
              R L  L+L  N L  +PE +     L  L+++ N+L  LP  +  L+ L++      
Sbjct: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428

Query: 199 -----------------LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
                            L+ S N++  +P EI     ++++ L+ N++   P  L  L S
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488

Query: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
           L  L ++ N ++ +P D++    L  L+L +N+L
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKL 522



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 1/158 (0%)

Query: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEA-LGALPALTFLTVTHNRLQTLPP 188
           ++L    L+  P  +L+++ +  L L  N +     A  G L  L  L++  N L +LP 
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205

Query: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
            +  L  L+ L++S N +  +P EI  LG++ +L   +N +++ P+ L  L +L +L L 
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265

Query: 249 SNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
            N L  +P  L  L  L  L+L  NQL   P  L   P
Sbjct: 266 KNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 48/168 (28%), Positives = 85/168 (50%), Gaps = 3/168 (1%)

Query: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
           P GL  L  L +L ++ N +  +P  +   + L  L LS N L    E   +L  L +L 
Sbjct: 480 PLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLD 539

Query: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
           +  N+++ +P ++  + +L  L L  N  +T P E+  L +L  L+L+ N+LQ + + + 
Sbjct: 540 LGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC 599

Query: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLD---LRDNQLRDLPPEL 282
            L+ ++ L   SN     P +L +L  L +L+   ++  +L  LP EL
Sbjct: 600 NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGEL 647



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 67/262 (25%), Positives = 111/262 (42%), Gaps = 43/262 (16%)

Query: 48  QQLLHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTL 106
           +QLLHL + +  L +    F  L   +   L +  + ++P S+S + SL          L
Sbjct: 510 KQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISL--------HVL 561

Query: 107 GACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHN-------- 158
             C     T  P  L  L +L  LDLS N L+ + + +  ++G+  L  S N        
Sbjct: 562 ILCCNKFET-FPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE 620

Query: 159 -C-----------------LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLD 200
            C                 L+ LP  L  +  L  L +++N ++ +P  +G L  L  L 
Sbjct: 621 LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH 680

Query: 201 LSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLA 260
              N +  LPP +  L  L +LNL+ N L +LP+++  + SL+ +    N L   P ++ 
Sbjct: 681 AYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC 740

Query: 261 R-------LPLLTRLDLRDNQL 275
           +          L R D RD ++
Sbjct: 741 KGKQLYTIARYLQRADERDEKI 762


>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
           containing 1 [Homo sapiens]
          Length = 728

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 63/175 (36%), Positives = 94/175 (53%), Gaps = 5/175 (2%)

Query: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
           L+     DLS N L  +P  +     L  L L HNC+  +PEA+  L  LT+L ++ N+L
Sbjct: 96  LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155

Query: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
             LP  L  L  L+ L  S N L +LP EIG L  L+EL+++ N + +LP  +  L+SLR
Sbjct: 156 SALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLR 214

Query: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFVRLQGNPL 295
            L +  N L  +P +L  LPL+ + D   N++  +P    E+     + L+ NPL
Sbjct: 215 ELNVRRNYLKVLPQELVDLPLV-KFDFSCNKVLVIPICFREMKQLQVLLLENNPL 268



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 47/142 (33%), Positives = 67/142 (47%), Gaps = 23/142 (16%)

Query: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
           +P  +  L  L +L+LS N L  LPAC+  +  L  L+ S+N L  LPE +G L  L  L
Sbjct: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMEL 193

Query: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------------------- 217
            V+ N +  LP  +G L +L+ L++ +N L  LP E+  L                    
Sbjct: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFR 253

Query: 218 ---SLLELNLASNRLQSLPASL 236
               L  L L +N LQS PA +
Sbjct: 254 EMKQLQVLLLENNPLQSPPAQI 275



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 23/168 (13%)

Query: 50  LLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
           L H C+    +  + L  + +L LS ++        L+ LP   +CL  L LK       
Sbjct: 127 LYHNCIRVIPEAIVNLQMLTYLNLSRNQ--------LSALP---ACLCGLPLK------- 168

Query: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
           +       L +LP  +  L  L  LD+S N +  LP  + Q++ L  L +  N L  LP+
Sbjct: 169 VLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQ 228

Query: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
            L  LP + F   + N++  +P     +  LQ L L  N L + P +I
Sbjct: 229 ELVDLPLVKF-DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275


>gi|167466264 leucine rich repeat containing 18 [Homo sapiens]
          Length = 261

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 48/146 (32%), Positives = 87/146 (59%), Gaps = 2/146 (1%)

Query: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
           LDLS   + T P C+L++  +  L LS N + ++P+++     L +L +  N +  LP +
Sbjct: 32  LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91

Query: 190 LGALSTLQRLDLSQNLLDT--LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVL 247
           +G +++L  L++S N L +  LP E+  L ++  +NL  N L S+P +L  L+ L  + L
Sbjct: 92  IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151

Query: 248 HSNLLASVPADLARLPLLTRLDLRDN 273
           H NLL ++P  +++LP L +L+++ N
Sbjct: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 52/165 (31%), Positives = 75/165 (45%), Gaps = 5/165 (3%)

Query: 111 RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSE--LPEALG 168
           R  +  +P  +S   +L  LDL  N ++ LP  + QM  L  L +S+N L+   LP  L 
Sbjct: 59  RNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELK 118

Query: 169 ALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNR 228
            L  +  + +  N L ++P  LGAL  L  + L  NLL+ +P  I  L  L +LN+  N 
Sbjct: 119 QLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNP 178

Query: 229 LQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN 273
                 S   + S+R L    NL      DL    L    + RDN
Sbjct: 179 FPKPGESEIFIDSIRRL---ENLYVVEEKDLCAACLRKCQNARDN 220



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 32/95 (33%), Positives = 55/95 (57%), Gaps = 2/95 (2%)

Query: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
           +RLDLS+  + T P  I  L  + EL+L+ N ++ +P S++  ++LR L LHSN +  +P
Sbjct: 30  KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89

Query: 257 ADLARLPLLTRLDLRDNQL--RDLPPELLDAPFVR 289
             + ++  L  L++ +N+L    LP EL     +R
Sbjct: 90  ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIR 124


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 146/612 (23%), Positives = 248/612 (40%), Gaps = 69/612 (11%)

Query: 300  PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 357
            P +P++  +  I  +     T  L SF V  +G S+  +   G+R+  P    A P  I 
Sbjct: 932  PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 991

Query: 358  YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 414
             RL+ P+    P  L   + L S ++ L P G  F   V + +       R  RE+VV R
Sbjct: 992  CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1051

Query: 415  TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 455
            + N + W +      E+YL+             EE  ++         F  +F+++SR  
Sbjct: 1052 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1111

Query: 456  SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 515
             +   + PEG  L S   P V+  FP  A  +  ++++Q   +    +  LLG  +A  S
Sbjct: 1112 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1170

Query: 516  PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 567
            P++ + +     F +P+ +++PLP   T         D + L LL         A W+DI
Sbjct: 1171 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1229

Query: 568  TAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 624
            T    L   +  A F     + +WL    +       A   ++ L    +    +   + 
Sbjct: 1230 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1289

Query: 625  RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 682
             DP +  L+  C+  +KVD TL +  E +     S  +E+ EG   FA     + V   +
Sbjct: 1290 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1347

Query: 683  PDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQR 742
                  +  F F S  +N   + +   +   ++   G +SF R A+     +        
Sbjct: 1348 ---AAQQRSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHI------ 1396

Query: 743  KGADALWMATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLL 793
                   +  L I +P   +  G+E  RR    L+L    L ++  G L+     +  + 
Sbjct: 1397 -------LCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMA 1449

Query: 794  SVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLL 853
             ++  LGL W  +A  L  S  ++ RIR E  + L EQ   +L  W  R+ GQ   +  L
Sbjct: 1450 VISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENL 1508

Query: 854  VQALEQSDRQDV 865
              AL+  DR ++
Sbjct: 1509 YTALQSIDRGEI 1520


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,869,428
Number of Sequences: 37866
Number of extensions: 1959385
Number of successful extensions: 8122
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 6238
Number of HSP's gapped (non-prelim): 1010
length of query: 910
length of database: 18,247,518
effective HSP length: 111
effective length of query: 799
effective length of database: 14,044,392
effective search space: 11221469208
effective search space used: 11221469208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.