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Search of human proteins with 61742782
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61742782 leucine rich repeat and death domain containing
protein isoform 2 [Homo sapiens]
(753 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61742782 leucine rich repeat and death domain containing prot... 1508 0.0
gi|61742784 leucine rich repeat and death domain containing prot... 1499 0.0
gi|61742786 leucine rich repeat and death domain containing prot... 1456 0.0
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 105 2e-22
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 97 5e-20
gi|40217803 leucine rich repeat containing 8 family, member E [H... 95 3e-19
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 94 5e-19
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 92 1e-18
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 92 1e-18
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 92 2e-18
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 91 5e-18
gi|45827729 scribble isoform b [Homo sapiens] 91 5e-18
gi|45827731 scribble isoform a [Homo sapiens] 91 5e-18
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 90 9e-18
gi|62241040 leucine rich repeat containing 8 family, member A [H... 88 3e-17
gi|187829877 leucine rich repeat containing 8 family, member A [... 88 3e-17
gi|187829871 leucine rich repeat containing 8 family, member A [... 88 3e-17
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 88 3e-17
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 87 6e-17
gi|19923729 leucine rich repeat containing 8 family, member C [H... 87 7e-17
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens] 86 2e-16
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 86 2e-16
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 85 3e-16
gi|238908508 leucine-rich repeat and death domain-containing pro... 84 4e-16
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 84 4e-16
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 84 4e-16
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 84 4e-16
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 84 4e-16
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 84 4e-16
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 84 5e-16
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 1508 bits (3903), Expect = 0.0
Identities = 753/753 (100%), Positives = 753/753 (100%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
Query: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180
RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF
Sbjct: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180
Query: 181 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 240
PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH
Sbjct: 181 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 240
Query: 241 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 300
GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS
Sbjct: 241 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 300
Query: 301 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 360
WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL
Sbjct: 301 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 360
Query: 361 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 420
LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD
Sbjct: 361 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 420
Query: 421 ITAQVVLELTHLYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPR 480
ITAQVVLELTHLYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPR
Sbjct: 421 ITAQVVLELTHLYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPR 480
Query: 481 NKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSH 540
NKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSH
Sbjct: 481 NKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEGRICFVFYSH 540
Query: 541 LKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKL 600
LKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKL
Sbjct: 541 LKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKL 600
Query: 601 PRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREV 660
PRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREV
Sbjct: 601 PRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREV 660
Query: 661 QRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGR 720
QRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGR
Sbjct: 661 QRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVAEEVRAVLELGR 720
Query: 721 RKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 753
RKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA
Sbjct: 721 RKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 753
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 1499 bits (3881), Expect = 0.0
Identities = 753/764 (98%), Positives = 753/764 (98%), Gaps = 11/764 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL
Sbjct: 147 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT
Sbjct: 207 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 266
Query: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180
RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF
Sbjct: 267 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 326
Query: 181 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 240
PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH
Sbjct: 327 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 386
Query: 241 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 300
GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS
Sbjct: 387 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 446
Query: 301 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 360
WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL
Sbjct: 447 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 506
Query: 361 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 420
LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD
Sbjct: 507 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 566
Query: 421 ITAQVVLELTHL-----------YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 469
ITAQVVLELTHL YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD
Sbjct: 567 ITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 626
Query: 470 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 529
PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV
Sbjct: 627 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 686
Query: 530 EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD 589
EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD
Sbjct: 687 EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD 746
Query: 590 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 649
ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV
Sbjct: 747 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 806
Query: 650 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 709
ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA
Sbjct: 807 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 866
Query: 710 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 753
EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA
Sbjct: 867 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 910
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 1456 bits (3770), Expect = 0.0
Identities = 736/764 (96%), Positives = 736/764 (96%), Gaps = 28/764 (3%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL
Sbjct: 147 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT
Sbjct: 207 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 266
Query: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180
RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF
Sbjct: 267 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 326
Query: 181 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 240
PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH
Sbjct: 327 PVTPQGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPH 386
Query: 241 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 300
GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS
Sbjct: 387 GVAFQQDVGLWLLFTPPQARRCREVVVRTRNDNSWGDLETYLEEEAPQRLWAHCQVPHFS 446
Query: 301 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 360
WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL
Sbjct: 447 WFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQAL 506
Query: 361 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 420
LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD
Sbjct: 507 LGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRLHLLYWAPPAATWDD 566
Query: 421 ITAQVVLELTHL-----------YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 469
ITAQVVLELTHL YWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD
Sbjct: 567 ITAQVVLELTHLYARFQVTHFSWYWLWYTTKNCVGGLARKAWERLRLHRVNLIALQRRRD 626
Query: 470 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 529
PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV
Sbjct: 627 PEQVLLQCLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCV 686
Query: 530 EGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGAD 589
EGRICFVFYSHLKNVKE VSFYRGAVPVRVPEEAEAARQRKGAD
Sbjct: 687 EGRICFVFYSHLKNVKE-----------------VSFYRGAVPVRVPEEAEAARQRKGAD 729
Query: 590 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 649
ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV
Sbjct: 730 ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAV 789
Query: 650 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 709
ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA
Sbjct: 790 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 849
Query: 710 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 753
EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA
Sbjct: 850 EEVRAVLELGRRKYQDSIRRMGLAPKDPALPGSSAPQPPEPAQA 893
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 105 bits (261), Expect = 2e-22
Identities = 68/149 (45%), Positives = 91/149 (61%), Gaps = 5/149 (3%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L HNCL L ALG L ALT+L ++ N+L LPP + L L+ L +S N L L
Sbjct: 93 LEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGAL 151
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
PP+IG LGSL +L+++SN LQSLP+ L GL SLR L + N L+++P +L LPL+ RLD
Sbjct: 152 PPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLV-RLD 210
Query: 124 LRDNQLRDLPP---ELLDAPFVRLQGNPL 149
N++ +P L + L NPL
Sbjct: 211 FSCNRVSRIPVSFCRLRHLQVILLDSNPL 239
Score = 79.7 bits (195), Expect = 9e-15
Identities = 55/159 (34%), Positives = 84/159 (52%), Gaps = 20/159 (12%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L++S+N L LP +G L +L L V+ N LQ+LP L LS+L+ L++ +N L TL
Sbjct: 138 LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLT 120
P E+G L L+ L+ + NR+ +P S LR L++++L SN L S PA + +L +
Sbjct: 198 PEELGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
Query: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSS 159
L Q +G+ LG+ +P P S
Sbjct: 257 YLSTEAGQ----------------RGSALGDLAPSRPPS 279
Score = 72.4 bits (176), Expect = 1e-12
Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 4/135 (2%)
Query: 5 GALLLSHNCLSELPEALGA---LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
G L LS+ L P L +T ++ NR +P A L +L+ L L N L
Sbjct: 45 GTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLR 104
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
L P +G L +L LNL+ N+L LP + L LR+L++ +N L ++P D+ L L +
Sbjct: 105 CLNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQ 163
Query: 122 LDLRDNQLRDLPPEL 136
LD+ N+L+ LP EL
Sbjct: 164 LDVSSNELQSLPSEL 178
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
L + + +L+ NR +P + L SL L L+ N L + L L LT L+L NQL
Sbjct: 67 LSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQL 126
Query: 130 RDLPPELLDAPF--VRLQGNPLGEASPD 155
LPP + P + + N LG PD
Sbjct: 127 SLLPPYICQLPLRVLIVSNNKLGALPPD 154
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 97.1 bits (240), Expect = 5e-20
Identities = 62/145 (42%), Positives = 84/145 (57%), Gaps = 8/145 (5%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
R L L LS NC E+P +L L AL L++ N+LQ++P + L +L+ L L N +
Sbjct: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
+PPE+G L SL L L N++QS+P L+ L SLR L LH+NLL +P ++ L L
Sbjct: 180 EIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEE 239
Query: 122 LDLRDNQL-----RDL---PPELLD 138
L LR N L RDL PP LL+
Sbjct: 240 LSLRGNPLVVRFVRDLTYDPPTLLE 264
Score = 78.2 bits (191), Expect = 3e-14
Identities = 59/141 (41%), Positives = 74/141 (52%), Gaps = 7/141 (4%)
Query: 7 LLLSHNCLSELPEALGA-LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPP 65
LLL HN L LP ALG+ P L L V+ N L L P L AL L+ L N L
Sbjct: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
Query: 66 EIGGLG------SLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 119
GL SL LNL+ N Q +PASL LR+L+ L L N L S+PA++ L L
Sbjct: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
Query: 120 TRLDLRDNQLRDLPPELLDAP 140
L L N ++++PPEL + P
Sbjct: 169 ECLYLGGNFIKEIPPELGNLP 189
Score = 63.5 bits (153), Expect = 7e-10
Identities = 35/83 (42%), Positives = 49/83 (59%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L L N + E+P LG LP+L +L + N++Q++PP L L +L+ L L NLL
Sbjct: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
Query: 61 DTLPPEIGGLGSLLELNLASNRL 83
LP EI L L EL+L N L
Sbjct: 225 TYLPREILNLIHLEELSLRGNPL 247
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/142 (32%), Positives = 68/142 (47%), Gaps = 2/142 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L L N L +P + L +L L + N ++ +PP LG L +L L L N +
Sbjct: 142 LRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKI 201
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSN-LLASVPADLA-RLPL 118
++PP++ L SL L+L +N L LP + L L L L N L+ DL P
Sbjct: 202 QSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPT 261
Query: 119 LTRLDLRDNQLRDLPPELLDAP 140
L L R ++R++ D P
Sbjct: 262 LLELAARTIKIRNISYTPYDLP 283
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 94.7 bits (234), Expect = 3e-19
Identities = 57/135 (42%), Positives = 83/135 (61%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
R L L L HN ++ +PE + L +L L +++N+L+TLP LG S L+ LD+S N L
Sbjct: 630 RKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLH 689
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
+LPPE+G L +L L L+ N L++LP L R LR L+L N L+ + + L L+R
Sbjct: 690 SLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSR 749
Query: 122 LDLRDNQLRDLPPEL 136
L+L+ N+L LP EL
Sbjct: 750 LELKGNRLEALPEEL 764
Score = 82.4 bits (202), Expect = 1e-15
Identities = 54/140 (38%), Positives = 70/140 (50%), Gaps = 2/140 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L LS+N L LP LG L L V+HN L +LPP +G L LQ L LS N L
Sbjct: 652 LRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNAL 711
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+ LP E+ L L L N+L L + LR+L L L N L ++P +L L
Sbjct: 712 EALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLK 771
Query: 121 RLDL--RDNQLRDLPPELLD 138
+ L D + LP E+ D
Sbjct: 772 KAGLLVEDTLYQGLPAEVRD 791
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 94.0 bits (232), Expect = 5e-19
Identities = 57/133 (42%), Positives = 77/133 (57%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L +SHN L LPE + L L L + HN L + LS L+ LDLS N L
Sbjct: 127 LENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHL 186
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
T+P L SL+ LNL+SN L+SLPA + ++ L+ L +SNLL ++P +LA + L
Sbjct: 187 TTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLE 246
Query: 121 RLDLRDNQLRDLP 133
L LR N+LR LP
Sbjct: 247 LLYLRRNKLRFLP 259
Score = 87.0 bits (214), Expect = 6e-17
Identities = 54/133 (40%), Positives = 75/133 (56%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L++S+N L L + L LPALT L + N+L +LP A+ L LQ+L++S N L L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P EI L +L L L N L + L +L L L +N L +VPA + L L RL+
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 124 LRDNQLRDLPPEL 136
L N+L+ LP E+
Sbjct: 204 LSSNELKSLPAEI 216
Score = 69.7 bits (169), Expect = 9e-12
Identities = 49/144 (34%), Positives = 78/144 (54%), Gaps = 5/144 (3%)
Query: 10 SHNCLSELPEALGALPALTF-LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
S N L E+P+ + L + + ++ N+L + L L L LDL N L++LP E+
Sbjct: 433 SKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEME 492
Query: 69 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASV-PADLARLPLLTRLDLRDN 127
L L +NL+ NR + LP L + +L +++ +N + SV P + + LT LDL++N
Sbjct: 493 SLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNN 552
Query: 128 QLRDLPPELLDAPFVR---LQGNP 148
L +PPEL + +R L GNP
Sbjct: 553 DLLQIPPELGNCVNLRTLLLDGNP 576
Score = 67.0 bits (162), Expect = 6e-11
Identities = 56/209 (26%), Positives = 90/209 (43%), Gaps = 47/209 (22%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L LS+N L+ +P + +L +L L ++ N L++LP + + L+ LD + NLL
Sbjct: 173 LSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLL 232
Query: 61 DTLPPEIGG----------------------------------------------LGSLL 74
+T+PPE+ G L S+L
Sbjct: 233 ETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSIL 292
Query: 75 ELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPP 134
L+L N+L+S+P + LRSL L L +N ++S+P L L L L L N LR +
Sbjct: 293 VLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRR 351
Query: 135 ELLDAPFVRLQGNPLGEASPDAPSSPVAA 163
E++ + + D PS +A
Sbjct: 352 EIISKGTQEVLKYLRSKIKDDGPSQSESA 380
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/105 (30%), Positives = 58/105 (55%), Gaps = 1/105 (0%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L L +N L+ LPE + +L L + ++ NR + LP L + TL+ + +S N +
Sbjct: 471 LQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
Query: 61 DTLPPE-IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSN 104
++ P+ + + +L L+L +N L +P L +LR L+L N
Sbjct: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 92.4 bits (228), Expect = 1e-18
Identities = 48/127 (37%), Positives = 77/127 (60%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S N ++ LP
Sbjct: 258 LLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSS 317
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
IG L +L N LQ LP + +++ +L LHSN L ++P ++ + L ++L D
Sbjct: 318 IGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSD 377
Query: 127 NQLRDLP 133
N+L++LP
Sbjct: 378 NRLKNLP 384
Score = 75.1 bits (183), Expect = 2e-13
Identities = 45/138 (32%), Positives = 73/138 (52%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L +S N + + E + L L ++ N LQ LP +G+L + L + +N L
Sbjct: 229 LKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQL 288
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
LP IGGL S+ EL+ + N +++LP+S+ L +LR N L +P ++ +T
Sbjct: 289 MYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNIT 348
Query: 121 RLDLRDNQLRDLPPELLD 138
L L N+L LP E+ D
Sbjct: 349 VLFLHSNKLETLPEEMGD 366
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/136 (32%), Positives = 70/136 (51%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ GL + N L+ +P +G+L LT+L V+ N ++ + + LQ L LS N L
Sbjct: 206 LSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSL 265
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
LP IG L ++ L + N+L LP S+ GL S+ L N + ++P+ + +L L
Sbjct: 266 QQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLR 325
Query: 121 RLDLRDNQLRDLPPEL 136
N L+ LPPE+
Sbjct: 326 TFAADHNYLQQLPPEI 341
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/130 (34%), Positives = 67/130 (51%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L N + ELP+ L +L L++ N L TLP ++ L L+ LD+S+N +
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P I L + + N + LP + L +L L L+ L +PA+ RL L L+
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 124 LRDNQLRDLP 133
LR+NQL+ LP
Sbjct: 168 LRENQLKMLP 177
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/133 (31%), Positives = 68/133 (51%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L N +E+PE L L L + NRL +P +G+L L LD+S+N ++ +
Sbjct: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMV 245
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
I +L +L L+SN LQ LP ++ L+++ L + N L +P + L + LD
Sbjct: 246 EEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELD 305
Query: 124 LRDNQLRDLPPEL 136
N++ LP +
Sbjct: 306 CSFNEVEALPSSI 318
Score = 62.4 bits (150), Expect = 2e-09
Identities = 44/135 (32%), Positives = 65/135 (48%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
+ L L L N L+ LP ++ L L L V+ N +Q P + L ++ S N +
Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPIS 128
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
LP L +L +L L L+ LPA+ L L++L L N L +P + RL L R
Sbjct: 129 KLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
Query: 122 LDLRDNQLRDLPPEL 136
LDL N+ ++P L
Sbjct: 189 LDLGSNEFTEVPEVL 203
Score = 60.8 bits (146), Expect = 4e-09
Identities = 41/130 (31%), Positives = 60/130 (46%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L+ L LP G L L L + N+L+ LP + L+ L+RLDL N +
Sbjct: 140 LTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEV 199
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P + L L E + +NRL +P + L+ L L + N + V ++ L L
Sbjct: 200 PEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLL 259
Query: 124 LRDNQLRDLP 133
L N L+ LP
Sbjct: 260 LSSNSLQQLP 269
Score = 57.0 bits (136), Expect = 6e-08
Identities = 42/130 (32%), Positives = 59/130 (45%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L +S N + E PE + LT + + N + LP L L +L L+ L+ L
Sbjct: 94 LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL 153
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P G L L L L N+L+ LP ++ L L L L SN VP L +L L
Sbjct: 154 PANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
Query: 124 LRDNQLRDLP 133
+ N+L +P
Sbjct: 214 MDANRLTFIP 223
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 22 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 80
G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 81 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 133
N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 45 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 103
G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 104 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 136
N L ++PA +A L L LD+ N +++ P +
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
Score = 47.8 bits (112), Expect = 4e-05
Identities = 27/86 (31%), Positives = 44/86 (51%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L HN L +LP +G+ +T L + N+L+TLP +G + L+ ++LS N L
Sbjct: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSL 86
LP L L + L+ N+ + L
Sbjct: 381 KNLPFSFTKLQQLTAMWLSDNQSKPL 406
Score = 35.4 bits (80), Expect = 0.20
Identities = 21/64 (32%), Positives = 31/64 (48%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
+ + L L N L LPE +G + L + ++ NRL+ LP + L L + LS N
Sbjct: 345 KNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSK 404
Query: 62 TLPP 65
L P
Sbjct: 405 PLIP 408
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 92.4 bits (228), Expect = 1e-18
Identities = 48/127 (37%), Positives = 77/127 (60%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S N ++ LP
Sbjct: 258 LLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSS 317
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
IG L +L N LQ LP + +++ +L LHSN L ++P ++ + L ++L D
Sbjct: 318 IGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSD 377
Query: 127 NQLRDLP 133
N+L++LP
Sbjct: 378 NRLKNLP 384
Score = 75.1 bits (183), Expect = 2e-13
Identities = 45/138 (32%), Positives = 73/138 (52%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L +S N + + E + L L ++ N LQ LP +G+L + L + +N L
Sbjct: 229 LKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQL 288
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
LP IGGL S+ EL+ + N +++LP+S+ L +LR N L +P ++ +T
Sbjct: 289 MYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNIT 348
Query: 121 RLDLRDNQLRDLPPELLD 138
L L N+L LP E+ D
Sbjct: 349 VLFLHSNKLETLPEEMGD 366
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/136 (32%), Positives = 70/136 (51%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ GL + N L+ +P +G+L LT+L V+ N ++ + + LQ L LS N L
Sbjct: 206 LSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSL 265
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
LP IG L ++ L + N+L LP S+ GL S+ L N + ++P+ + +L L
Sbjct: 266 QQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLR 325
Query: 121 RLDLRDNQLRDLPPEL 136
N L+ LPPE+
Sbjct: 326 TFAADHNYLQQLPPEI 341
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/130 (34%), Positives = 67/130 (51%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L N + ELP+ L +L L++ N L TLP ++ L L+ LD+S+N +
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P I L + + N + LP + L +L L L+ L +PA+ RL L L+
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 124 LRDNQLRDLP 133
LR+NQL+ LP
Sbjct: 168 LRENQLKMLP 177
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/133 (31%), Positives = 68/133 (51%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L N +E+PE L L L + NRL +P +G+L L LD+S+N ++ +
Sbjct: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMV 245
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
I +L +L L+SN LQ LP ++ L+++ L + N L +P + L + LD
Sbjct: 246 EEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELD 305
Query: 124 LRDNQLRDLPPEL 136
N++ LP +
Sbjct: 306 CSFNEVEALPSSI 318
Score = 62.4 bits (150), Expect = 2e-09
Identities = 44/135 (32%), Positives = 65/135 (48%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
+ L L L N L+ LP ++ L L L V+ N +Q P + L ++ S N +
Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPIS 128
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
LP L +L +L L L+ LPA+ L L++L L N L +P + RL L R
Sbjct: 129 KLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
Query: 122 LDLRDNQLRDLPPEL 136
LDL N+ ++P L
Sbjct: 189 LDLGSNEFTEVPEVL 203
Score = 60.8 bits (146), Expect = 4e-09
Identities = 41/130 (31%), Positives = 60/130 (46%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L+ L LP G L L L + N+L+ LP + L+ L+RLDL N +
Sbjct: 140 LTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEV 199
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P + L L E + +NRL +P + L+ L L + N + V ++ L L
Sbjct: 200 PEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLL 259
Query: 124 LRDNQLRDLP 133
L N L+ LP
Sbjct: 260 LSSNSLQQLP 269
Score = 57.0 bits (136), Expect = 6e-08
Identities = 42/130 (32%), Positives = 59/130 (45%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L +S N + E PE + LT + + N + LP L L +L L+ L+ L
Sbjct: 94 LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL 153
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P G L L L L N+L+ LP ++ L L L L SN VP L +L L
Sbjct: 154 PANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
Query: 124 LRDNQLRDLP 133
+ N+L +P
Sbjct: 214 MDANRLTFIP 223
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 22 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 80
G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 81 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 133
N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 45 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 103
G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L
Sbjct: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
Query: 104 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 136
N L ++PA +A L L LD+ N +++ P +
Sbjct: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
Score = 47.8 bits (112), Expect = 4e-05
Identities = 27/86 (31%), Positives = 44/86 (51%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L HN L +LP +G+ +T L + N+L+TLP +G + L+ ++LS N L
Sbjct: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSL 86
LP L L + L+ N+ + L
Sbjct: 381 KNLPFSFTKLQQLTAMWLSDNQSKPL 406
Score = 35.4 bits (80), Expect = 0.20
Identities = 21/64 (32%), Positives = 31/64 (48%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
+ + L L N L LPE +G + L + ++ NRL+ LP + L L + LS N
Sbjct: 345 KNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSK 404
Query: 62 TLPP 65
L P
Sbjct: 405 PLIP 408
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 91.7 bits (226), Expect = 2e-18
Identities = 66/166 (39%), Positives = 90/166 (54%), Gaps = 5/166 (3%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L LSHN L LP LGAL L L V+ NRL LP +L LS L+ LD+ N L
Sbjct: 134 LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQL 193
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
P ++ L +L EL+++SNRL+ LP ++ LR+L++L L L ++PA L L
Sbjct: 194 TAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLE 253
Query: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIP 166
L L +N L+ LP A F LQ + S + AAL+P
Sbjct: 254 SLMLDNNGLQALP-----AQFSCLQRLKMLNLSSNLFEEFPAALLP 294
Score = 85.1 bits (209), Expect = 2e-16
Identities = 56/135 (41%), Positives = 77/135 (57%), Gaps = 2/135 (1%)
Query: 4 LGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTL-PPALGALSTLQRLDLSQNLLD 61
L L+L N + LP A+ L LT L V+HNRL L + AL L++L+LS N L
Sbjct: 89 LRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLP 148
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
LP ++G L L EL+++ NRL LP SL+ L LR L + N L + P L +L L
Sbjct: 149 ALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEE 208
Query: 122 LDLRDNQLRDLPPEL 136
LD+ N+LR LP ++
Sbjct: 209 LDVSSNRLRGLPEDI 223
Score = 77.8 bits (190), Expect = 3e-14
Identities = 52/156 (33%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L +L+L +N L LP L L L ++ N + P AL L+ L+ L LS+N L
Sbjct: 249 LASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQL 308
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
++P I GLG LL L L +NR++ LP S+ L L LVL N +A +P +L +
Sbjct: 309 TSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVG 368
Query: 121 RLDLRDNQLRDLPPE--LLDAPFVRLQGNPLGEASP 154
++DN L P E + P++ L + P
Sbjct: 369 LWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQP 404
Score = 76.3 bits (186), Expect = 1e-13
Identities = 56/130 (43%), Positives = 69/130 (53%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L + HN L+ P L L AL L V+ NRL+ LP + AL L+ L LS L TL
Sbjct: 183 LRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTL 242
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P L SL L L +N LQ+LPA + L+ L++L L SNL PA L L L L
Sbjct: 243 PAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELY 302
Query: 124 LRDNQLRDLP 133
L NQL +P
Sbjct: 303 LSRNQLTSVP 312
Score = 76.3 bits (186), Expect = 1e-13
Identities = 56/149 (37%), Positives = 78/149 (52%), Gaps = 3/149 (2%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L +S N L LPE + AL AL L ++ L TLP L++L+ L L N L L
Sbjct: 206 LEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQAL 265
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P + L L LNL+SN + PA+L L L L L N L SVP+ ++ L L L
Sbjct: 266 PAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLW 325
Query: 124 LRDNQLRDLPPELLDAPFVR---LQGNPL 149
L +N++R LP +++ + LQGN +
Sbjct: 326 LDNNRIRYLPDSIVELTGLEELVLQGNQI 354
Score = 72.4 bits (176), Expect = 1e-12
Identities = 52/152 (34%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L LS L LP L +L L + +N LQ LP L L+ L+LS NL
Sbjct: 226 LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLF 285
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+ P + L L EL L+ N+L S+P+ ++GL L L L +N + +P + L L
Sbjct: 286 EEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLE 345
Query: 121 RLDLRDNQLRDLPP---ELLDAPFVRLQGNPL 149
L L+ NQ+ LP +L +++ NPL
Sbjct: 346 ELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/119 (29%), Positives = 52/119 (43%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ GL L LS N L+ +P + L L L + +NR++ LP ++ L+ L+ L L N +
Sbjct: 295 LAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQI 354
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 119
LP G L + + N L P + + L S PA RL LL
Sbjct: 355 AVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLL 413
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/72 (41%), Positives = 42/72 (58%), Gaps = 2/72 (2%)
Query: 70 LGSLLELNLASNRLQSLPASL-AGLRSLRLLVLHSNLLASVPADLARL-PLLTRLDLRDN 127
LG + LNL +N L+ +P L + L SLR+LVL N A +P +A L LT LD+ N
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
Query: 128 QLRDLPPELLDA 139
+L L E++ A
Sbjct: 122 RLTALGAEVVSA 133
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 90.5 bits (223), Expect = 5e-18
Identities = 68/190 (35%), Positives = 100/190 (52%), Gaps = 13/190 (6%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
LLLS N L +LP+++G L LT L V N+L LP +G LS L+ D S N L++LP
Sbjct: 258 LLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPST 317
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
IG L SL L + N L LP + +++ ++ L SN L +P ++ ++ L L+L D
Sbjct: 318 IGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSD 377
Query: 127 NQLRDLP---PELLDAPFVRLQGN------PL-GEASPDAPSSPVA-ALIPEMPR--LFL 173
N+L++LP +L + + L N PL EA P+ + + P+ PR
Sbjct: 378 NRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDF 437
Query: 174 TSDLDSFPVT 183
SD DSF T
Sbjct: 438 QSDSDSFNPT 447
Score = 82.0 bits (201), Expect = 2e-15
Identities = 50/130 (38%), Positives = 71/130 (54%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L +N ELPE L + L L + +N LQ LP ++G L L LD+S+N ++T+
Sbjct: 186 LERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETV 245
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
+I G +L +L L+SN LQ LP S+ L+ L L + N L +P + L LL D
Sbjct: 246 DMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFD 305
Query: 124 LRDNQLRDLP 133
N+L LP
Sbjct: 306 CSCNELESLP 315
Score = 78.6 bits (192), Expect = 2e-14
Identities = 49/159 (30%), Positives = 77/159 (48%), Gaps = 23/159 (14%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT--------------------- 39
++ L L + +N L LP ++G L L +L ++ NR++T
Sbjct: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
Query: 40 --LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 97
LP ++G L L L + N L LP IG L L E + + N L+SLP+++ L SLR
Sbjct: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325
Query: 98 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 136
L + N L +P ++ +T + LR N+L LP E+
Sbjct: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI 364
Score = 74.7 bits (182), Expect = 3e-13
Identities = 45/130 (34%), Positives = 69/130 (53%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L N L LP+++ L L L + +N LP L + L+ L + N L L
Sbjct: 163 LRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVL 222
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P IG L L+ L+++ NR++++ ++G +L L+L SN+L +P + L LT L
Sbjct: 223 PGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLK 282
Query: 124 LRDNQLRDLP 133
+ DNQL LP
Sbjct: 283 VDDNQLTMLP 292
Score = 68.9 bits (167), Expect = 2e-11
Identities = 45/135 (33%), Positives = 66/135 (48%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
R L L L N + ELP+ L AL L++ N L LP + +L L+ LD+S+N +
Sbjct: 46 RTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQ 105
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
P I L + + N + LP L +L L L+ L +PA+ RL L
Sbjct: 106 EFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRI 165
Query: 122 LDLRDNQLRDLPPEL 136
L+LR+N L+ LP +
Sbjct: 166 LELRENHLKTLPKSM 180
Score = 66.2 bits (160), Expect = 1e-10
Identities = 46/137 (33%), Positives = 70/137 (51%), Gaps = 1/137 (0%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
+ L L + N LS LP + +L L L ++ N +Q P + L ++ S N +
Sbjct: 69 QALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPIS 128
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
LP L +L +L L L+ LPA+ L LR+L L N L ++P + +L L R
Sbjct: 129 KLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLER 188
Query: 122 LDLRDNQLRDLPPELLD 138
LDL +N+ +L PE+LD
Sbjct: 189 LDLGNNEFGEL-PEVLD 204
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/127 (32%), Positives = 67/127 (52%)
Query: 10 SHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGG 69
S N +S+LP+ L LT L + L+ LP G L L+ L+L +N L TLP +
Sbjct: 123 SVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHK 182
Query: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
L L L+L +N LP L +++LR L + +N L +P + +L +L LD+ N++
Sbjct: 183 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRI 242
Query: 130 RDLPPEL 136
+ ++
Sbjct: 243 ETVDMDI 249
Score = 49.3 bits (116), Expect = 1e-05
Identities = 28/86 (32%), Positives = 46/86 (53%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L + N L ELP +G+ +T +++ N+L+ LP +G + L+ L+LS N L
Sbjct: 321 LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRL 380
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSL 86
LP L L L L+ N+ ++L
Sbjct: 381 KNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 35.0 bits (79), Expect = 0.26
Identities = 22/64 (34%), Positives = 31/64 (48%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
+ + + L N L LPE +G + L L ++ NRL+ LP + L L L LS N
Sbjct: 345 KNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSK 404
Query: 62 TLPP 65
L P
Sbjct: 405 ALIP 408
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 90.5 bits (223), Expect = 5e-18
Identities = 60/156 (38%), Positives = 80/156 (51%), Gaps = 23/156 (14%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L N L LP+ LGALP L L + N+L LPP LG L L LD+S+N L+ L
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL-----------------------LV 100
P E+GGL L +L L+ N L+ LP + L+ L + L+
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295
Query: 101 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 136
L NLL ++P L +L LT L++ N L LPPE+
Sbjct: 296 LTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 88.6 bits (218), Expect = 2e-17
Identities = 52/127 (40%), Positives = 71/127 (55%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
LLLS N L LP+ +G L L+ L V NRL + A+G L L L++NLL LP
Sbjct: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
+G L L LN+ N L++LP + G +L +L L N LA +P +LA L LD+
Sbjct: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAG 367
Query: 127 NQLRDLP 133
N+L+ LP
Sbjct: 368 NRLQSLP 374
Score = 85.1 bits (209), Expect = 2e-16
Identities = 54/138 (39%), Positives = 76/138 (55%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L L N L LP +L L L L + N L+ LP LGAL L+ L L +N L
Sbjct: 150 LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQL 209
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
LPPE+G L L+ L+++ NRL+ LPA L GL L L+L NLL +P + +L L+
Sbjct: 210 SALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLS 269
Query: 121 RLDLRDNQLRDLPPELLD 138
L + N+L ++ + D
Sbjct: 270 ILKVDQNRLCEVTEAIGD 287
Score = 84.7 bits (208), Expect = 3e-16
Identities = 56/133 (42%), Positives = 73/133 (54%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L L+ L LP +G L L L + N L++LP +L L L++LDL N L
Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL 186
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+ LP +G L +L EL L N+L +LP L LR L L + N L +PA+L L LLT
Sbjct: 187 EVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLT 246
Query: 121 RLDLRDNQLRDLP 133
L L N LR LP
Sbjct: 247 DLLLSQNLLRRLP 259
Score = 83.6 bits (205), Expect = 6e-16
Identities = 51/127 (40%), Positives = 73/127 (57%)
Query: 10 SHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGG 69
S N LS LP+ L +L L + LQ LP +G L+ L L+L +NLL +LP +
Sbjct: 113 SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172
Query: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
L L +L+L N L+ LP +L L +LR L L N L+++P +L L L LD+ +N+L
Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232
Query: 130 RDLPPEL 136
+LP EL
Sbjct: 233 EELPAEL 239
Score = 79.3 bits (194), Expect = 1e-14
Identities = 52/132 (39%), Positives = 73/132 (55%), Gaps = 1/132 (0%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L + N L E+ EA+G L+ L +T N L LP +LG L+ L L++ +N L
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+ LPPEIGG +L L+L NRL LP LA L +L + N L S+P L L L
Sbjct: 325 EALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLN-LK 383
Query: 121 RLDLRDNQLRDL 132
L L +NQ + +
Sbjct: 384 ALWLAENQAQPM 395
Score = 79.0 bits (193), Expect = 2e-14
Identities = 61/169 (36%), Positives = 80/169 (47%), Gaps = 9/169 (5%)
Query: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
+S N + E+PE++ AL + N L LP L +L L L+ L LP ++G
Sbjct: 89 VSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVG 148
Query: 69 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQ 128
L +L+ L L N L+SLPASL+ L L L L N L +P L LP L L L NQ
Sbjct: 149 NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQ 208
Query: 129 LRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDL 177
L LPPEL GN D + + L E+ L L +DL
Sbjct: 209 LSALPPEL---------GNLRRLVCLDVSENRLEELPAELGGLVLLTDL 248
Score = 75.1 bits (183), Expect = 2e-13
Identities = 58/172 (33%), Positives = 84/172 (48%), Gaps = 3/172 (1%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
R L LLL N L ELP+ L L L ++ N +Q LPP + L LD+S+N +
Sbjct: 36 RSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIP 95
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
+P I +L + + N L LP LRSL L L+ L ++P D+ L L
Sbjct: 96 EIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155
Query: 122 LDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFL 173
L+LR+N L+ LP L + V+L+ LG + + AL P + L+L
Sbjct: 156 LELRENLLKSLPASL--SFLVKLEQLDLGGNDLEVLPDTLGAL-PNLRELWL 204
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 90.5 bits (223), Expect = 5e-18
Identities = 60/156 (38%), Positives = 80/156 (51%), Gaps = 23/156 (14%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L N L LP+ LGALP L L + N+L LPP LG L L LD+S+N L+ L
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL-----------------------LV 100
P E+GGL L +L L+ N L+ LP + L+ L + L+
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 295
Query: 101 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 136
L NLL ++P L +L LT L++ N L LPPE+
Sbjct: 296 LTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Score = 88.6 bits (218), Expect = 2e-17
Identities = 52/127 (40%), Positives = 71/127 (55%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
LLLS N L LP+ +G L L+ L V NRL + A+G L L L++NLL LP
Sbjct: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
+G L L LN+ N L++LP + G +L +L L N LA +P +LA L LD+
Sbjct: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAG 367
Query: 127 NQLRDLP 133
N+L+ LP
Sbjct: 368 NRLQSLP 374
Score = 85.1 bits (209), Expect = 2e-16
Identities = 54/138 (39%), Positives = 76/138 (55%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L L N L LP +L L L L + N L+ LP LGAL L+ L L +N L
Sbjct: 150 LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQL 209
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
LPPE+G L L+ L+++ NRL+ LPA L GL L L+L NLL +P + +L L+
Sbjct: 210 SALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLS 269
Query: 121 RLDLRDNQLRDLPPELLD 138
L + N+L ++ + D
Sbjct: 270 ILKVDQNRLCEVTEAIGD 287
Score = 84.7 bits (208), Expect = 3e-16
Identities = 56/133 (42%), Positives = 73/133 (54%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L L+ L LP +G L L L + N L++LP +L L L++LDL N L
Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL 186
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+ LP +G L +L EL L N+L +LP L LR L L + N L +PA+L L LLT
Sbjct: 187 EVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLT 246
Query: 121 RLDLRDNQLRDLP 133
L L N LR LP
Sbjct: 247 DLLLSQNLLRRLP 259
Score = 83.6 bits (205), Expect = 6e-16
Identities = 51/127 (40%), Positives = 73/127 (57%)
Query: 10 SHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGG 69
S N LS LP+ L +L L + LQ LP +G L+ L L+L +NLL +LP +
Sbjct: 113 SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172
Query: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
L L +L+L N L+ LP +L L +LR L L N L+++P +L L L LD+ +N+L
Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232
Query: 130 RDLPPEL 136
+LP EL
Sbjct: 233 EELPAEL 239
Score = 79.3 bits (194), Expect = 1e-14
Identities = 52/132 (39%), Positives = 73/132 (55%), Gaps = 1/132 (0%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L + N L E+ EA+G L+ L +T N L LP +LG L+ L L++ +N L
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+ LPPEIGG +L L+L NRL LP LA L +L + N L S+P L L L
Sbjct: 325 EALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLN-LK 383
Query: 121 RLDLRDNQLRDL 132
L L +NQ + +
Sbjct: 384 ALWLAENQAQPM 395
Score = 79.0 bits (193), Expect = 2e-14
Identities = 61/169 (36%), Positives = 80/169 (47%), Gaps = 9/169 (5%)
Query: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
+S N + E+PE++ AL + N L LP L +L L L+ L LP ++G
Sbjct: 89 VSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVG 148
Query: 69 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQ 128
L +L+ L L N L+SLPASL+ L L L L N L +P L LP L L L NQ
Sbjct: 149 NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQ 208
Query: 129 LRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDL 177
L LPPEL GN D + + L E+ L L +DL
Sbjct: 209 LSALPPEL---------GNLRRLVCLDVSENRLEELPAELGGLVLLTDL 248
Score = 75.1 bits (183), Expect = 2e-13
Identities = 58/172 (33%), Positives = 84/172 (48%), Gaps = 3/172 (1%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
R L LLL N L ELP+ L L L ++ N +Q LPP + L LD+S+N +
Sbjct: 36 RSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIP 95
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
+P I +L + + N L LP LRSL L L+ L ++P D+ L L
Sbjct: 96 EIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155
Query: 122 LDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFL 173
L+LR+N L+ LP L + V+L+ LG + + AL P + L+L
Sbjct: 156 LELRENLLKSLPASL--SFLVKLEQLDLGGNDLEVLPDTLGAL-PNLRELWL 204
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 89.7 bits (221), Expect = 9e-18
Identities = 57/139 (41%), Positives = 79/139 (56%), Gaps = 6/139 (4%)
Query: 4 LGALL------LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQ 57
+GALL L N LSELP+ +G L L L V+ NRL+ LP + L++L L +SQ
Sbjct: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252
Query: 58 NLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLP 117
NLL+T+P IG L L L + NRL LP ++ SL LVL N L ++P + +L
Sbjct: 253 NLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLK 312
Query: 118 LLTRLDLRDNQLRDLPPEL 136
L+ L+ N+L LP E+
Sbjct: 313 KLSNLNADRNKLVSLPKEI 331
Score = 88.6 bits (218), Expect = 2e-17
Identities = 53/130 (40%), Positives = 78/130 (60%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L +L L N L+ LP++L L L L + +N + LP ++GAL L+ L L N L L
Sbjct: 153 LASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSEL 212
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P EIG L +LL L+++ NRL+ LP ++GL SL LV+ NLL ++P + +L L+ L
Sbjct: 213 PQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILK 272
Query: 124 LRDNQLRDLP 133
+ N+L LP
Sbjct: 273 VDQNRLTQLP 282
Score = 88.2 bits (217), Expect = 3e-17
Identities = 52/136 (38%), Positives = 74/136 (54%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L++S N L +P+ +G L L+ L V NRL LP A+G +L L L++N L
Sbjct: 242 LTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQL 301
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
TLP IG L L LN N+L SLP + G SL + + N L +PA++++ L
Sbjct: 302 LTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELH 361
Query: 121 RLDLRDNQLRDLPPEL 136
LD+ N+L LP L
Sbjct: 362 VLDVAGNRLLHLPLSL 377
Score = 87.4 bits (215), Expect = 4e-17
Identities = 52/136 (38%), Positives = 77/136 (56%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L L +N + LPE++GAL L L + N+L LP +G L L LD+S+N L
Sbjct: 173 LRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL 232
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+ LP EI GL SL +L ++ N L+++P + L+ L +L + N L +P + LT
Sbjct: 233 ERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLT 292
Query: 121 RLDLRDNQLRDLPPEL 136
L L +NQL LP +
Sbjct: 293 ELVLTENQLLTLPKSI 308
Score = 86.3 bits (212), Expect = 1e-16
Identities = 52/139 (37%), Positives = 75/139 (53%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L +S N L LPE + L +LT L ++ N L+T+P +G L L L + QN L
Sbjct: 219 LKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRL 278
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
LP +G SL EL L N+L +LP S+ L+ L L N L S+P ++ LT
Sbjct: 279 TQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLT 338
Query: 121 RLDLRDNQLRDLPPELLDA 139
+RDN+L +P E+ A
Sbjct: 339 VFCVRDNRLTRIPAEVSQA 357
Score = 81.6 bits (200), Expect = 2e-15
Identities = 50/127 (39%), Positives = 72/127 (56%)
Query: 10 SHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGG 69
S N L+ LPE+ L LT L+V LQ+LP +G L L L+L +NLL LP +
Sbjct: 113 SGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQ 172
Query: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
L L EL+L +N + +LP S+ L L+ L L N L+ +P ++ L L LD+ +N+L
Sbjct: 173 LRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL 232
Query: 130 RDLPPEL 136
LP E+
Sbjct: 233 ERLPEEI 239
Score = 81.6 bits (200), Expect = 2e-15
Identities = 56/160 (35%), Positives = 80/160 (50%), Gaps = 1/160 (0%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L + N L++LPEA+G +LT L +T N+L TLP ++G L L L+ +N L
Sbjct: 265 LKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKL 324
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+LP EIGG SL + NRL +PA ++ L +L + N L +P L L L
Sbjct: 325 VSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LK 383
Query: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSP 160
L L DNQ + L D + + P PS P
Sbjct: 384 ALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEP 423
Score = 72.0 bits (175), Expect = 2e-12
Identities = 48/135 (35%), Positives = 68/135 (50%)
Query: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
R L LLL N L ELPE L L L ++ N +Q LPP + L LD+S+N +
Sbjct: 36 RSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIP 95
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
+P I +L + + N L LP S L++L L ++ L S+P ++ L L
Sbjct: 96 EIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLAS 155
Query: 122 LDLRDNQLRDLPPEL 136
L+LR+N L LP L
Sbjct: 156 LELRENLLTYLPDSL 170
Score = 67.0 bits (162), Expect = 6e-11
Identities = 46/128 (35%), Positives = 64/128 (50%)
Query: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
+S N + E+PE++ AL + N L LP + L L L ++ L +LP IG
Sbjct: 89 VSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIG 148
Query: 69 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQ 128
L +L L L N L LP SL LR L L L +N + ++P + L L L L NQ
Sbjct: 149 NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQ 208
Query: 129 LRDLPPEL 136
L +LP E+
Sbjct: 209 LSELPQEI 216
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 88.2 bits (217), Expect = 3e-17
Identities = 53/143 (37%), Positives = 83/143 (58%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L +N ++ +P +G L L L + N+++ +P L L+ LDLS N L L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P +IG L +L L + +NR+++LP L R LR L L +N+L S+P+ + L LT+++
Sbjct: 701 PADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIE 760
Query: 124 LRDNQLRDLPPELLDAPFVRLQG 146
LR N+L LP EL + P ++ G
Sbjct: 761 LRGNRLECLPVELGECPLLKRSG 783
Score = 82.8 bits (203), Expect = 1e-15
Identities = 49/138 (35%), Positives = 75/138 (54%), Gaps = 2/138 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L L+ N + ++P L L +L ++HN L LP +G L LQ L ++ N +
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+TLPPE+ L L+L +N LQSLP+ + L +L + L N L +P +L PLL
Sbjct: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Query: 121 R--LDLRDNQLRDLPPEL 136
R L + ++ LPPE+
Sbjct: 781 RSGLVVEEDLFNTLPPEV 798
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 88.2 bits (217), Expect = 3e-17
Identities = 53/143 (37%), Positives = 83/143 (58%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L +N ++ +P +G L L L + N+++ +P L L+ LDLS N L L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P +IG L +L L + +NR+++LP L R LR L L +N+L S+P+ + L LT+++
Sbjct: 701 PADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIE 760
Query: 124 LRDNQLRDLPPELLDAPFVRLQG 146
LR N+L LP EL + P ++ G
Sbjct: 761 LRGNRLECLPVELGECPLLKRSG 783
Score = 82.8 bits (203), Expect = 1e-15
Identities = 49/138 (35%), Positives = 75/138 (54%), Gaps = 2/138 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L L+ N + ++P L L +L ++HN L LP +G L LQ L ++ N +
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+TLPPE+ L L+L +N LQSLP+ + L +L + L N L +P +L PLL
Sbjct: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Query: 121 R--LDLRDNQLRDLPPEL 136
R L + ++ LPPE+
Sbjct: 781 RSGLVVEEDLFNTLPPEV 798
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 88.2 bits (217), Expect = 3e-17
Identities = 53/143 (37%), Positives = 83/143 (58%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L +N ++ +P +G L L L + N+++ +P L L+ LDLS N L L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P +IG L +L L + +NR+++LP L R LR L L +N+L S+P+ + L LT+++
Sbjct: 701 PADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIE 760
Query: 124 LRDNQLRDLPPELLDAPFVRLQG 146
LR N+L LP EL + P ++ G
Sbjct: 761 LRGNRLECLPVELGECPLLKRSG 783
Score = 82.8 bits (203), Expect = 1e-15
Identities = 49/138 (35%), Positives = 75/138 (54%), Gaps = 2/138 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L L+ N + ++P L L +L ++HN L LP +G L LQ L ++ N +
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+TLPPE+ L L+L +N LQSLP+ + L +L + L N L +P +L PLL
Sbjct: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Query: 121 R--LDLRDNQLRDLPPEL 136
R L + ++ LPPE+
Sbjct: 781 RSGLVVEEDLFNTLPPEV 798
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 87.8 bits (216), Expect = 3e-17
Identities = 58/149 (38%), Positives = 85/149 (57%), Gaps = 5/149 (3%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L HNC+ +PEA+ L LT+L ++ N L TLP L L L+ L +S N L ++
Sbjct: 136 LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSI 194
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P EIG L L+EL+++ N +Q LP + L SLR L + N L +P +L LPL+ +LD
Sbjct: 195 PEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLV-KLD 253
Query: 124 LRDNQLRDLP---PELLDAPFVRLQGNPL 149
N++ ++P +L + L NPL
Sbjct: 254 FSCNKVTEIPVCYRKLHHLQVIILDNNPL 282
Score = 73.9 bits (180), Expect = 5e-13
Identities = 47/157 (29%), Positives = 86/157 (54%), Gaps = 6/157 (3%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L++S+N L +PE +G L L L ++ N +Q LP +G L +L+ L++ +N L L
Sbjct: 181 LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL 240
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLT 120
P E+G L L++L+ + N++ +P L L++++L +N L PA + ++ +
Sbjct: 241 PDELGDL-PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFK 299
Query: 121 RLDLRDNQLRDLPPELLDAPFV--RLQGNPLGEASPD 155
L+++ D P+ LD P + R+ PL ++ D
Sbjct: 300 YLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMED 336
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/180 (31%), Positives = 88/180 (48%), Gaps = 10/180 (5%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
L +S N LS LP+ L LP L L V++N+L ++P +G L L LD+S N + LP +
Sbjct: 162 LNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQ 220
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
+G L SL ELN+ N L LP L L ++ L N + +P +L L + L +
Sbjct: 221 MGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDN 279
Query: 127 NQLRDLPPELL------DAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSF 180
N L+ P ++ ++ +Q + PD+ P +L MP LT ++ F
Sbjct: 280 NPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLP--SLSKRMPSQPLTDSMEDF 337
Score = 50.4 bits (119), Expect = 6e-06
Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 2/132 (1%)
Query: 5 GALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLP 64
G+L H S L AL + L+++ +L+ P + L+ + DLS+N +P
Sbjct: 69 GSLQPQHTVRS-LDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIP 127
Query: 65 PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDL 124
++ L LNL N ++++P ++ L+ L L + NLL+++P L LPL L +
Sbjct: 128 SDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKV-LVV 186
Query: 125 RDNQLRDLPPEL 136
+N+L +P E+
Sbjct: 187 SNNKLVSIPEEI 198
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/104 (27%), Positives = 47/104 (45%)
Query: 37 LQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSL 96
+++L AL + L LS L P L + +L+ NR +P+ + L
Sbjct: 77 VRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 136
Query: 97 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 140
L L+ N + ++P + L +LT L++ N L LP L D P
Sbjct: 137 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 87.0 bits (214), Expect = 6e-17
Identities = 54/166 (32%), Positives = 90/166 (54%), Gaps = 2/166 (1%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L ++ NCL+E+P L L L+++HN L LP LS L++L+LS N +
Sbjct: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHI 178
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P + L L+ L++ SNRL+++ S+ L SL++ + N + S P L + L L+
Sbjct: 179 PMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLN 238
Query: 124 LRDNQLRDLPPEL-LDAPFVRLQGNPLGEASPDAPSSPVAALIPEM 168
L +N ++ LP EL L VR+ NP+ + +P++ +PE+
Sbjct: 239 LNNNDIQTLPSELHLLCRLVRIAWNPM-DKGLHISHNPLSKPLPEL 283
Score = 74.3 bits (181), Expect = 4e-13
Identities = 46/117 (39%), Positives = 67/117 (57%), Gaps = 1/117 (0%)
Query: 27 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSL 86
++F VT + +P L LS +Q+L+LS N L LPPE+G L ++ LNL NRL+SL
Sbjct: 51 VSFSLVTRG-MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSL 109
Query: 87 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR 143
P ++ L+ L++L ++ N L VPA+L+ L L L N L LP D +R
Sbjct: 110 PREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLR 166
Score = 70.1 bits (170), Expect = 7e-12
Identities = 42/120 (35%), Positives = 68/120 (56%)
Query: 14 LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSL 73
++++P+ L L + L ++HN+L+ LPP +G L+ + L+L N L +LP E+ L L
Sbjct: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
Query: 74 LELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 133
L + N L +PA L+ R L +L L N L+ +PA A L L +L+L +N +P
Sbjct: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
Score = 67.4 bits (163), Expect = 5e-11
Identities = 45/126 (35%), Positives = 65/126 (51%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
L LSHN L LP +G L + L + NRL++LP + L L+ L ++ N L +P E
Sbjct: 76 LNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAE 135
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
+ L L+L+ N L LPA A L LR L L +N A +P + L L L +
Sbjct: 136 LSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGS 195
Query: 127 NQLRDL 132
N+L ++
Sbjct: 196 NRLENI 201
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 86.7 bits (213), Expect = 7e-17
Identities = 50/146 (34%), Positives = 82/146 (56%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L L HN ++ +PE + L +L L+ +HN+++ LP L + ++ LDLS N +
Sbjct: 636 LRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDI 695
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+PPEIG L SL ++ N+++SLP L + L+ L + N L+ + + L L+
Sbjct: 696 RFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLS 755
Query: 121 RLDLRDNQLRDLPPELLDAPFVRLQG 146
LD++ N LPPEL D ++ G
Sbjct: 756 YLDVKGNHFEILPPELGDCRALKRAG 781
Score = 32.3 bits (72), Expect = 1.7
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 52 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 111
RL+L +L LP + + L L L + +PA++A L +L+ L LH SV
Sbjct: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQ---CSVKI 481
Query: 112 DLARLPLLTR----LDLRDNQLRDLPP 134
A L L L ++ + +R+LPP
Sbjct: 482 HSAALSFLKENLKVLSVKFDDMRELPP 508
>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
Length = 1001
Score = 85.5 bits (210), Expect = 2e-16
Identities = 143/599 (23%), Positives = 242/599 (40%), Gaps = 97/599 (16%)
Query: 177 LDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIRYRLL----LPEPGLVPLGPHDAL 230
L SF V +G S+ + G+R+ P P I RL+ L P P+ + L
Sbjct: 119 LVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPP--PMVEGEGL 176
Query: 231 LSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-RTRNDNSWG---------DLET 280
S ++E+ P G F V + + + RE++V R+ N +W DL
Sbjct: 177 ASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTE 236
Query: 281 YL-----EEEAPQRLWAH--CQV---PHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGV 330
L E ++P+ L C++ +F VVSR + + PEG +L S+ P V
Sbjct: 237 LLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLV 296
Query: 331 KVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQL 390
+ FP GA + RV +Q + ++ +LG +A SP++ + + F +P+T+ +
Sbjct: 297 QASFPEGALTKRIRVGLQAQPVPDEIVKKILGN-KATFSPIVTV-EPRRRKFHKPITMTI 354
Query: 391 PLP--------SGITGLSLDRSRLHL-LYWAPPAATWDDITAQVVL-----------ELT 430
P+P +G G + RL + A W+DIT L ++
Sbjct: 355 PVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVS 414
Query: 431 HLYWLWYTTKNC-----VGGLARKAWERLRL--HRVNLIALQRRRDPEQVLLQ--CLPRN 481
+WL +C GLA + + L + + + DP + L+ C+ +
Sbjct: 415 ARFWL----ADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDD 470
Query: 482 KVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADRPDCVEG--RICFVFYS 539
KVD TL + E + S +E+ EG+ + +D + +G ++ F FYS
Sbjct: 471 KVDKTLEQ-QENFEEVARSKDIEVLEGKPIY------VDCYGNLAPLTKGGQQLVFNFYS 523
Query: 540 HLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIK 599
+N + + + +Q G++SF + + KG + L I
Sbjct: 524 FKEN--RLPFSIKIRDTSQEPCGRLSFLK------------EPKTTKGLPQTAVCNLNIT 569
Query: 600 LP---RLRGSEGPRRGAGLSLAPLNLGDAETGFLTQS-------NLLSVAGRLGLDWPAV 649
LP ++ ++ + A L+L E G QS + VA LGL W +
Sbjct: 570 LPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTEL 629
Query: 650 ALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDV 708
A L S E+ +IR E + L Q +L W R G+ L L + +R D+
Sbjct: 630 ARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRD-GKNATTDALTSVLTKINRIDI 687
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 85.5 bits (210), Expect = 2e-16
Identities = 56/149 (37%), Positives = 84/149 (56%), Gaps = 5/149 (3%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L L HNC+ +PEA+ L LT+L ++ N+L LP L L L+ L S N L +L
Sbjct: 122 LEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSL 180
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P EIG L L+EL+++ N + +LP + L+SLR L + N L +P +L LPL+ + D
Sbjct: 181 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLV-KFD 239
Query: 124 LRDNQLRDLP---PELLDAPFVRLQGNPL 149
N++ +P E+ + L+ NPL
Sbjct: 240 FSCNKVLVIPICFREMKQLQVLLLENNPL 268
Score = 64.7 bits (156), Expect = 3e-10
Identities = 45/135 (33%), Positives = 69/135 (51%), Gaps = 4/135 (2%)
Query: 5 GALLLSHNCLSELPEALGA---LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
G L LS L E P L ++ NRL +P L +L+ L+L N +
Sbjct: 74 GGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIR 133
Query: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
+P I L L LNL+ N+L +LPA L GL L++L+ +N L S+P ++ +L L
Sbjct: 134 VIPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLME 192
Query: 122 LDLRDNQLRDLPPEL 136
LD+ N++ LP ++
Sbjct: 193 LDVSCNEITALPQQI 207
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/83 (34%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
L ++ +L+ NRL +P L SL +L L+ N + +P + L +LT L+L NQL
Sbjct: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
Query: 130 RDLPPELLDAPFVRL--QGNPLG 150
LP L P L N LG
Sbjct: 156 SALPACLCGLPLKVLIASNNKLG 178
Score = 38.5 bits (88), Expect = 0.023
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L +S N ++ LP+ +G L +L L V N L+ LP L L L + D S N +
Sbjct: 187 LKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKV 245
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASL 90
+P + L L L +N LQS PA +
Sbjct: 246 LVIPICFREMKQLQVLLLENNPLQSPPAQI 275
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 84.7 bits (208), Expect = 3e-16
Identities = 51/130 (39%), Positives = 74/130 (56%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
L L N + +PEA+G+L L L ++ N L+ + P +G L L+ L L+ N L LPPE
Sbjct: 70 LYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
+G L L L++++NRL +LP L SL+ L + N L VP L +LP L L +
Sbjct: 130 VGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
Query: 127 NQLRDLPPEL 136
N+L LP +L
Sbjct: 190 NRLAFLPLDL 199
Score = 79.3 bits (194), Expect = 1e-14
Identities = 53/138 (38%), Positives = 75/138 (54%), Gaps = 1/138 (0%)
Query: 4 LGALLLSHNCLSELPEALGA-LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 62
L L + N L+ LPE L LP L L + N + +P A+G+L LQ LDLS N L+
Sbjct: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
Query: 63 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 122
+ PEIG L +L L LA+N+LQ LP + L+ L+ L + +N L ++P L L L
Sbjct: 103 VCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYL 162
Query: 123 DLRDNQLRDLPPELLDAP 140
+ N+L +P L P
Sbjct: 163 TVDRNRLWYVPRHLCQLP 180
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/134 (40%), Positives = 70/134 (52%), Gaps = 1/134 (0%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L LS N L + +G L AL L + +N+LQ LPP +G L LQ LD+S N L TL
Sbjct: 90 LQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTL 149
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P + SL L + NRL +P L L SL L + N LA +P DL R L +
Sbjct: 150 PERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVY 209
Query: 124 LRDN-QLRDLPPEL 136
+ +N L+ LP L
Sbjct: 210 VDNNIHLKGLPSYL 223
Score = 61.6 bits (148), Expect = 3e-09
Identities = 43/114 (37%), Positives = 63/114 (55%), Gaps = 1/114 (0%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+R L L L++N L LP +G L L L ++ NRL TLP L +LQ L + +N L
Sbjct: 110 LRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRL 169
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNL-LASVPADL 113
+P + L SL EL++A NRL LP L R L+ + + +N+ L +P+ L
Sbjct: 170 WYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/134 (35%), Positives = 72/134 (53%)
Query: 3 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 62
GL L L N LS LP + L L L V+HN + +P + L +++L N ++
Sbjct: 189 GLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248
Query: 63 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 122
P ++ LG+L L+L N+L+ +P +L L++LR+L L N L + P L LP L L
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
Query: 123 DLRDNQLRDLPPEL 136
DL N + LP E+
Sbjct: 309 DLTGNLISSLPKEI 322
Score = 80.1 bits (196), Expect = 7e-15
Identities = 48/133 (36%), Positives = 73/133 (54%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L L L +N L+ P+AL LP L L +T N + +LP + L L+ L + N L
Sbjct: 279 LKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKL 338
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
L EI L + EL LA N+L+ + + R LR+L+L NLL ++P ++ +L
Sbjct: 339 TFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE 398
Query: 121 RLDLRDNQLRDLP 133
L L DN+L +LP
Sbjct: 399 CLSLSDNKLTELP 411
Score = 67.4 bits (163), Expect = 5e-11
Identities = 41/128 (32%), Positives = 69/128 (53%)
Query: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
LS+N + P L AL +L +L+V N + +P + L L+LS+N L
Sbjct: 471 LSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFC 530
Query: 69 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQ 128
L +L L+L N+++ +PAS++ + SL +L+L N + P +L L L LDL +NQ
Sbjct: 531 SLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590
Query: 129 LRDLPPEL 136
L+ + ++
Sbjct: 591 LQKISSDI 598
Score = 66.2 bits (160), Expect = 1e-10
Identities = 39/123 (31%), Positives = 64/123 (52%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
L +N + P L L L L++ N+L+ +P L +L TL+ L+L N L T P
Sbjct: 239 LFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKA 298
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
+ L L+ L+L N + SLP + L++L L++ N L + ++ +L + L L D
Sbjct: 299 LCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLAD 358
Query: 127 NQL 129
N+L
Sbjct: 359 NKL 361
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/155 (30%), Positives = 74/155 (47%), Gaps = 6/155 (3%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
M L L+L N P L L L L ++ N+LQ + + L +Q+L+ S N
Sbjct: 555 MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF 614
Query: 61 DTLPPEIGGLGSLLELNLA---SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLP 117
P E+ L SL +LN++ +L LP L+ + L+ L + +N + +P ++ L
Sbjct: 615 IHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELR 674
Query: 118 LLTRLDLRDNQLRDLPPELL---DAPFVRLQGNPL 149
L L +NQ+ LPP LL D + L GN L
Sbjct: 675 NLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709
Score = 64.3 bits (155), Expect = 4e-10
Identities = 43/136 (31%), Positives = 69/136 (50%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
+ L L +SHN +S +P+ + L + L +N ++ P L L L+ L L +N L
Sbjct: 210 LHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKL 269
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+P + L +L LNL N+L + P +L L L L L NL++S+P ++ L L
Sbjct: 270 RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLE 329
Query: 121 RLDLRDNQLRDLPPEL 136
L + N+L L E+
Sbjct: 330 TLLMDHNKLTFLAVEI 345
Score = 64.3 bits (155), Expect = 4e-10
Identities = 37/126 (29%), Positives = 66/126 (52%)
Query: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
L L LS N L+ELP+ + L L L V N + + + L+ + L+ S N++ +
Sbjct: 397 LECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDV 456
Query: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
P EI ++++ L+ N++ P L L SL L ++ N ++ +P D++ L L+
Sbjct: 457 PIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLE 516
Query: 124 LRDNQL 129
L +N+L
Sbjct: 517 LSENKL 522
Score = 63.5 bits (153), Expect = 7e-10
Identities = 40/119 (33%), Positives = 61/119 (51%)
Query: 22 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 81
G L L L++ N L +LP + L L+ L++S N + +P EI LG++ +L +N
Sbjct: 185 GDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
Query: 82 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 140
+++ P+ L L +L +L L N L +P L L L L+L NQL P L P
Sbjct: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/130 (29%), Positives = 64/130 (49%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
L ++ N +SE+P + L L ++ N+L +L L+ LDL +N + +P
Sbjct: 492 LSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPAS 551
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
I + SL L L N+ ++ P L L +L++L L N L + +D+ L + +L+
Sbjct: 552 ISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSS 611
Query: 127 NQLRDLPPEL 136
NQ P EL
Sbjct: 612 NQFIHFPIEL 621
Score = 56.2 bits (134), Expect = 1e-07
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 7/123 (5%)
Query: 14 LSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSL 73
L+ LP L + L L +++N ++ +P +G L L L N + LPP + L L
Sbjct: 640 LTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDL 699
Query: 74 LELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLAR-------LPLLTRLDLRD 126
+LNL+ N L +LP+++ + SL+ + N L P ++ + L R D RD
Sbjct: 700 QQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERD 759
Query: 127 NQL 129
++
Sbjct: 760 EKI 762
Score = 56.2 bits (134), Expect = 1e-07
Identities = 34/90 (37%), Positives = 50/90 (55%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
M L L +S+N + E+P +G L L L +N++ LPP+L +L+ LQ+L+LS N L
Sbjct: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASL 90
LP I + SL E+N N L P +
Sbjct: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/136 (27%), Positives = 68/136 (50%)
Query: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
++ L LL+ HN L+ L + L + L + N+L+ + + L+ L L +NLL
Sbjct: 325 LKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLL 384
Query: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
+P +I L L+L+ N+L LP + L +LR L ++ N + + ++ L +
Sbjct: 385 KNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNIC 444
Query: 121 RLDLRDNQLRDLPPEL 136
L+ N + D+P E+
Sbjct: 445 SLEFSGNIITDVPIEI 460
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/133 (29%), Positives = 69/133 (51%), Gaps = 3/133 (2%)
Query: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
L LS N L E +L L +L + N+++ +P ++ + +L L L N +T P E
Sbjct: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
Query: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD--- 123
+ L +L L+L+ N+LQ + + + L+ ++ L SN P +L +L L +L+
Sbjct: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQ 634
Query: 124 LRDNQLRDLPPEL 136
++ +L LP EL
Sbjct: 635 IKGRKLTRLPGEL 647
Score = 31.6 bits (70), Expect = 2.8
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 1/85 (1%)
Query: 53 LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG-LRSLRLLVLHSNLLASVPA 111
++L L P +I + + L L N++++ + +G L L +L L N L+S+P+
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 112 DLARLPLLTRLDLRDNQLRDLPPEL 136
++ L L L++ N + +P E+
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEI 230
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 84.3 bits (207), Expect = 4e-16
Identities = 144/612 (23%), Positives = 246/612 (40%), Gaps = 80/612 (13%)
Query: 154 PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 211
P +P++ + I + T L SF V +G S+ + G+R+ P A P I
Sbjct: 932 PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 991
Query: 212 YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 268
RL+ P+ P L + L S ++ L P G F V + + R RE+VV R
Sbjct: 992 CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1051
Query: 269 TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 309
+ N + W + E+YL+ EE ++ F +F+++SR
Sbjct: 1052 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1111
Query: 310 SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 369
+ + PEG L S P V+ FP A + ++++Q + + LLG +A S
Sbjct: 1112 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1170
Query: 370 PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 421
P++ + + F +P+ +++PLP T D + L LL A W+DI
Sbjct: 1171 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1229
Query: 422 T-----------AQVVLELTHLYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 467
T A ++ +WL + A ++ L + + +
Sbjct: 1230 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1289
Query: 468 RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 525
DP + L+ C+ +KVD TL + E + S +E+ EG FA + V +
Sbjct: 1290 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1347
Query: 526 PDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQR 585
+ F F S +N + + + ++ G +SF R A+ +
Sbjct: 1348 ---AAQQRSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHI------ 1396
Query: 586 KGADALWMATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLL 636
+ L I +P + G+E RR L+L L ++ G L+ + +
Sbjct: 1397 -------LCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMA 1449
Query: 637 SVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLL 696
++ LGL W +A L S ++ RIR E + L EQ +L W R+ GQ + L
Sbjct: 1450 VISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENL 1508
Query: 697 VQALEQSDRQDV 708
AL+ DR ++
Sbjct: 1509 YTALQSIDRGEI 1520
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 84.3 bits (207), Expect = 4e-16
Identities = 144/612 (23%), Positives = 246/612 (40%), Gaps = 80/612 (13%)
Query: 154 PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 211
P +P++ + I + T L SF V +G S+ + G+R+ P A P I
Sbjct: 891 PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 950
Query: 212 YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 268
RL+ P+ P L + L S ++ L P G F V + + R RE+VV R
Sbjct: 951 CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1010
Query: 269 TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 309
+ N + W + E+YL+ EE ++ F +F+++SR
Sbjct: 1011 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1070
Query: 310 SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 369
+ + PEG L S P V+ FP A + ++++Q + + LLG +A S
Sbjct: 1071 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1129
Query: 370 PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 421
P++ + + F +P+ +++PLP T D + L LL A W+DI
Sbjct: 1130 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1188
Query: 422 T-----------AQVVLELTHLYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 467
T A ++ +WL + A ++ L + + +
Sbjct: 1189 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1248
Query: 468 RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 525
DP + L+ C+ +KVD TL + E + S +E+ EG FA + V +
Sbjct: 1249 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1306
Query: 526 PDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQR 585
+ F F S +N + + + ++ G +SF R A+ +
Sbjct: 1307 ---AAQQRSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHI------ 1355
Query: 586 KGADALWMATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLL 636
+ L I +P + G+E RR L+L L ++ G L+ + +
Sbjct: 1356 -------LCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMA 1408
Query: 637 SVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLL 696
++ LGL W +A L S ++ RIR E + L EQ +L W R+ GQ + L
Sbjct: 1409 VISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENL 1467
Query: 697 VQALEQSDRQDV 708
AL+ DR ++
Sbjct: 1468 YTALQSIDRGEI 1479
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 84.3 bits (207), Expect = 4e-16
Identities = 144/612 (23%), Positives = 246/612 (40%), Gaps = 80/612 (13%)
Query: 154 PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 211
P +P++ + I + T L SF V +G S+ + G+R+ P A P I
Sbjct: 891 PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 950
Query: 212 YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 268
RL+ P+ P L + L S ++ L P G F V + + R RE+VV R
Sbjct: 951 CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1010
Query: 269 TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 309
+ N + W + E+YL+ EE ++ F +F+++SR
Sbjct: 1011 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1070
Query: 310 SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 369
+ + PEG L S P V+ FP A + ++++Q + + LLG +A S
Sbjct: 1071 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1129
Query: 370 PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 421
P++ + + F +P+ +++PLP T D + L LL A W+DI
Sbjct: 1130 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1188
Query: 422 T-----------AQVVLELTHLYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 467
T A ++ +WL + A ++ L + + +
Sbjct: 1189 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1248
Query: 468 RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 525
DP + L+ C+ +KVD TL + E + S +E+ EG FA + V +
Sbjct: 1249 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1306
Query: 526 PDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQR 585
+ F F S +N + + + ++ G +SF R A+ +
Sbjct: 1307 ---AAQQRSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHI------ 1355
Query: 586 KGADALWMATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLL 636
+ L I +P + G+E RR L+L L ++ G L+ + +
Sbjct: 1356 -------LCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMA 1408
Query: 637 SVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLL 696
++ LGL W +A L S ++ RIR E + L EQ +L W R+ GQ + L
Sbjct: 1409 VISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENL 1467
Query: 697 VQALEQSDRQDV 708
AL+ DR ++
Sbjct: 1468 YTALQSIDRGEI 1479
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 84.3 bits (207), Expect = 4e-16
Identities = 144/612 (23%), Positives = 246/612 (40%), Gaps = 80/612 (13%)
Query: 154 PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 211
P +P++ + I + T L SF V +G S+ + G+R+ P A P I
Sbjct: 891 PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 950
Query: 212 YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 268
RL+ P+ P L + L S ++ L P G F V + + R RE+VV R
Sbjct: 951 CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1010
Query: 269 TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 309
+ N + W + E+YL+ EE ++ F +F+++SR
Sbjct: 1011 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1070
Query: 310 SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 369
+ + PEG L S P V+ FP A + ++++Q + + LLG +A S
Sbjct: 1071 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1129
Query: 370 PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 421
P++ + + F +P+ +++PLP T D + L LL A W+DI
Sbjct: 1130 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1188
Query: 422 T-----------AQVVLELTHLYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 467
T A ++ +WL + A ++ L + + +
Sbjct: 1189 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1248
Query: 468 RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 525
DP + L+ C+ +KVD TL + E + S +E+ EG FA + V +
Sbjct: 1249 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1306
Query: 526 PDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQR 585
+ F F S +N + + + ++ G +SF R A+ +
Sbjct: 1307 ---AAQQRSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHI------ 1355
Query: 586 KGADALWMATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLL 636
+ L I +P + G+E RR L+L L ++ G L+ + +
Sbjct: 1356 -------LCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMA 1408
Query: 637 SVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLL 696
++ LGL W +A L S ++ RIR E + L EQ +L W R+ GQ + L
Sbjct: 1409 VISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENL 1467
Query: 697 VQALEQSDRQDV 708
AL+ DR ++
Sbjct: 1468 YTALQSIDRGEI 1479
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 84.3 bits (207), Expect = 4e-16
Identities = 144/612 (23%), Positives = 246/612 (40%), Gaps = 80/612 (13%)
Query: 154 PDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSV--TLACGVRLQFPAGATATPITIR 211
P +P++ + I + T L SF V +G S+ + G+R+ P A P I
Sbjct: 891 PSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRIT 950
Query: 212 YRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTPPQARRCREVVV-R 268
RL+ P+ P L + L S ++ L P G F V + + R RE+VV R
Sbjct: 951 CRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLR 1010
Query: 269 TRNDNSWGDL-----ETYLE-------------EEAPQRLWAHCQVPHFS-WFLVVSRPV 309
+ N + W + E+YL+ EE ++ F +F+++SR
Sbjct: 1011 SENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLC 1070
Query: 310 SNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVS 369
+ + PEG L S P V+ FP A + ++++Q + + LLG +A S
Sbjct: 1071 QDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFS 1129
Query: 370 PLLCLSQSGPPSFLQPVTVQLPLPSGITGLSL-----DRSRLHLL---YWAPPAATWDDI 421
P++ + + F +P+ +++PLP T D + L LL A W+DI
Sbjct: 1130 PIVTV-EPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDI 1188
Query: 422 T-----------AQVVLELTHLYWLWYTTKNCVG-GLARKAWERLRL--HRVNLIALQRR 467
T A ++ +WL + A ++ L + + +
Sbjct: 1189 TGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKM 1248
Query: 468 RDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERGIDVDADR 525
DP + L+ C+ +KVD TL + E + S +E+ EG FA + V +
Sbjct: 1249 NDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGNL-VPVKK 1306
Query: 526 PDCVEGRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQR 585
+ F F S +N + + + ++ G +SF R A+ +
Sbjct: 1307 ---AAQQRSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHI------ 1355
Query: 586 KGADALWMATLPIKLP---RLRGSEGPRR-GAGLSLAPLNLGDAETGFLT-----QSNLL 636
+ L I +P + G+E RR L+L L ++ G L+ + +
Sbjct: 1356 -------LCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMA 1408
Query: 637 SVAGRLGLDWPAVALHLGVSYREVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLL 696
++ LGL W +A L S ++ RIR E + L EQ +L W R+ GQ + L
Sbjct: 1409 VISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIRE-GQNANMENL 1467
Query: 697 VQALEQSDRQDV 708
AL+ DR ++
Sbjct: 1468 YTALQSIDRGEI 1479
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 84.0 bits (206), Expect = 5e-16
Identities = 123/531 (23%), Positives = 216/531 (40%), Gaps = 67/531 (12%)
Query: 223 PLGPHDALLSHVLELQPHGVAFQQDVGLWLL-FTPPQARRCREVVVRTRNDNSWGD-LET 280
PL ++L+S +L+L P G F V + + F + + VV+R+ N +SW +
Sbjct: 1043 PLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCD 1102
Query: 281 YLEEE-------------APQRLWAH--CQV---PHFSWFLVVSRPVSNACLVPPEGTLL 322
Y E+E +P+ L C++ +F VVSR ++ L+ PEG +L
Sbjct: 1103 YTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVL 1162
Query: 323 CSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQSGPPSF 382
S+ P V+ +FP GA + RV +Q M ++ +LG +A SP++ L + F
Sbjct: 1163 SSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGN-KATFSPIVTL-EPRRRKF 1220
Query: 383 LQPVTVQLPLPSG-----ITGLSLDRSRLHLL---YWAPPAATWDDITAQVVLELTHLYW 434
+P+T+ +P+P + G D L LL A W+DIT L +
Sbjct: 1221 HKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECV 1280
Query: 435 LWYTTKNCVGGL--ARKAWERLRL------------HRVNLIALQRRRDPEQVLLQ--CL 478
+ T + L R+ E + + + + DP + L+ C+
Sbjct: 1281 SFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCM 1340
Query: 479 PRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFA-AFERGIDVDADRPDCVEGRICFVF 537
+KVD TL + E + S VE+ EG+ + F + + + F F
Sbjct: 1341 TDDKVDKTLEQ-QENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHI-----FSF 1394
Query: 538 YSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLP 597
++ +N ++V + Q G++SF ++ P+ + A TLP
Sbjct: 1395 FAFKENRLPLFV--KVRDTTQEPCGRLSF------MKEPKSTRGLVHQ--AICNLNITLP 1444
Query: 598 IKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSY 657
I + ++ + E + L +A LG W +A L +
Sbjct: 1445 IYTKESESDQEQEEEIDMTSEKNPQDEQER---IEERLAYIADHLGFSWTELARELDFTE 1501
Query: 658 REVQRIRHEFRDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDV 708
++ +IR E + L +Q +L W ER G+ LV+ L + +R D+
Sbjct: 1502 EQIHQIRIENPNSLQDQSHALLKYWLERD-GKHATDTNLVECLTKINRMDI 1551
Score = 30.4 bits (67), Expect = 6.3
Identities = 30/119 (25%), Positives = 51/119 (42%), Gaps = 9/119 (7%)
Query: 314 LVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLC 373
+V G + H G+++I PP P RV+ ++V+ + E E S L+
Sbjct: 964 MVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIE 1023
Query: 374 LSQSGPPSFLQPVTVQLPLPSGITGLSLDRSRL-HLLYWAPPAATWDDITAQVVLELTH 431
+ SG FL +L LP+ L+ S + +L PP + V++E+ H
Sbjct: 1024 VGPSG-AQFLG----KLHLPTAPPPLNEGESLVSRILQLGPPGTKF---LGPVIVEIPH 1074
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,587,974
Number of Sequences: 37866
Number of extensions: 1657432
Number of successful extensions: 6969
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 135
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 5554
Number of HSP's gapped (non-prelim): 863
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.