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Search of human proteins with 13540606
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13540606 caseinolytic peptidase B [Homo sapiens]
(707 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13540606 caseinolytic peptidase B [Homo sapiens] 1415 0.0
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 65 2e-10
gi|47933346 zinc finger, DHHC domain containing 13 isoform 1 [Ho... 59 2e-08
gi|14149653 torsin family 1, member B (torsin B) [Homo sapiens] 58 3e-08
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 56 1e-07
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 55 3e-07
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 55 3e-07
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 55 3e-07
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 52 1e-06
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 52 1e-06
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 52 1e-06
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 52 1e-06
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 52 1e-06
gi|47933348 zinc finger, DHHC domain containing 13 isoform 2 [Ho... 52 2e-06
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 52 2e-06
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa... 51 4e-06
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 50 7e-06
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 50 7e-06
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 50 7e-06
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 50 9e-06
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 50 9e-06
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 49 1e-05
gi|103471993 huntingtin interacting protein 14 [Homo sapiens] 49 1e-05
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 49 2e-05
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 49 2e-05
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 49 2e-05
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 49 2e-05
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 48 3e-05
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 48 3e-05
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 48 3e-05
>gi|13540606 caseinolytic peptidase B [Homo sapiens]
Length = 707
Score = 1415 bits (3662), Expect = 0.0
Identities = 707/707 (100%), Positives = 707/707 (100%)
Query: 1 MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSP 60
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSP
Sbjct: 1 MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSP 60
Query: 61 ALFSGRGAATGGRQGGRFDTKCLAAATWGRLPGPEETLPGQDSWNGVPSRAGLGMCALAA 120
ALFSGRGAATGGRQGGRFDTKCLAAATWGRLPGPEETLPGQDSWNGVPSRAGLGMCALAA
Sbjct: 61 ALFSGRGAATGGRQGGRFDTKCLAAATWGRLPGPEETLPGQDSWNGVPSRAGLGMCALAA 120
Query: 121 ALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN 180
ALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
Sbjct: 121 ALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN 180
Query: 181 SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWL 240
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWL
Sbjct: 181 SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWL 240
Query: 241 GLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH 300
GLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH
Sbjct: 241 GLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH 300
Query: 301 TPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAA 360
TPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAA
Sbjct: 301 TPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAA 360
Query: 361 IRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEV 420
IRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEV
Sbjct: 361 IRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEV 420
Query: 421 AKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGK 480
AKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGK
Sbjct: 421 AKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGK 480
Query: 481 GKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNF 540
GKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNF
Sbjct: 481 GKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNF 540
Query: 541 KENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLL 600
KENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLL
Sbjct: 541 KENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLL 600
Query: 601 WDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQL 660
WDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQL
Sbjct: 601 WDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQL 660
Query: 661 LKSPELPSPQAEKRLPKLRLEIIDKDSKTRRLDIRAPLHPEKVCNTI 707
LKSPELPSPQAEKRLPKLRLEIIDKDSKTRRLDIRAPLHPEKVCNTI
Sbjct: 661 LKSPELPSPQAEKRLPKLRLEIIDKDSKTRRLDIRAPLHPEKVCNTI 707
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 65.1 bits (157), Expect = 2e-10
Identities = 61/198 (30%), Positives = 94/198 (47%), Gaps = 31/198 (15%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG 196
ALL A++ +MQ V LL GA+++ + G TAL +AA V+++LLA+GA N
Sbjct: 115 ALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQP 174
Query: 197 -DDFSSVYKTAKEQGIHS------LEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLIT 249
D ++ A + G HS L G A+R N T+AL L
Sbjct: 175 RQDGTAPLWIASQMG-HSEVVRVMLLRGADRDAAR---NDGTTAL------------LKA 218
Query: 250 REDDFNNRLNNRASFK--------GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHT 301
+N+ + F G +ALH AVL+ + +TV LL+ GA+P RN+
Sbjct: 219 ANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANEL 278
Query: 302 PLDYAREGEVMKLLRTSE 319
P + + +++LLR+ E
Sbjct: 279 PAELTKNERILRLLRSKE 296
Score = 39.3 bits (90), Expect = 0.013
Identities = 23/60 (38%), Positives = 33/60 (55%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA 191
S+ L+ AA A ++ V L+ +GAD+N + G TAL AA +N VV+ L GA
Sbjct: 44 SHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGA 103
Score = 38.5 bits (88), Expect = 0.022
Identities = 54/191 (28%), Positives = 77/191 (40%), Gaps = 37/191 (19%)
Query: 141 AARANNMQEVSRLLSEG-ADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDF 199
AAR N+ + LL+ G DV+ + G T LMVAA + V+ L+ GAD NL
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL---- 74
Query: 200 SSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLN 259
+E G +L Q G + + R G A +D
Sbjct: 75 ------QRESGTTALFFAAQQGHNDVV----------RFLFGFGASTEFRTKD------- 111
Query: 260 NRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREG---EVMKLLR 316
G TAL A + V+ LL GAN + G T L A +G +V++LL
Sbjct: 112 ------GGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLL 165
Query: 317 TSEAKYQEKQR 327
S AK + ++
Sbjct: 166 ASGAKVNQPRQ 176
Score = 36.2 bits (82), Expect = 0.11
Identities = 36/136 (26%), Positives = 56/136 (41%), Gaps = 8/136 (5%)
Query: 62 LFSGRGAATGGRQGGRFDTKCLAAATWGRLPGPEETLPGQDSWNGVPSRAGLGMCALAAA 121
L+ G A QGG D L A+ G + P QD + + +G +
Sbjct: 142 LYDGATALFLAAQGGYLDVIRLLLAS-----GAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
Query: 122 LVVHCYSKSPSNKDA--ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRN 179
+++ + + D ALL+AA + LL + G +AL A ++ N
Sbjct: 197 MLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN-GTSALHAAVLSGN 255
Query: 180 NSVVQVLLAAGADPNL 195
V +LL AGADP+L
Sbjct: 256 IKTVALLLEAGADPSL 271
>gi|47933346 zinc finger, DHHC domain containing 13 isoform 1 [Homo
sapiens]
Length = 622
Score = 58.9 bits (141), Expect = 2e-08
Identities = 65/212 (30%), Positives = 100/212 (47%), Gaps = 16/212 (7%)
Query: 129 KSPSNKDAALLEAARANNMQEVSRL-LSEGADVNAKHR-LGWTALMVAAINRNNSVVQVL 186
+ P ++ +LL A NN ++ + +S+GA V+ L T L A + +V +L
Sbjct: 76 RQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILL 135
Query: 187 LAAGADPNL--GDDFSSVYKTAKEQG---IHSLEDGGQDGASRHITNQWTSALEFRRWLG 241
L GADP L G+ FSS++ Q I L GQ + Q L + +G
Sbjct: 136 LQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIG 195
Query: 242 L-PAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH 300
P G L+ FN LN T LH+AV A + V +LL+ G++ +N G
Sbjct: 196 PEPTGFLLK----FNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGE 251
Query: 301 TPLDYAREGE---VMKLLRTSEAKYQEKQRKR 329
TPLD A + + ++ +L+T EAK + Q+ R
Sbjct: 252 TPLDMALQNKNQLIIHMLKT-EAKMRANQKFR 282
>gi|14149653 torsin family 1, member B (torsin B) [Homo sapiens]
Length = 336
Score = 57.8 bits (138), Expect = 3e-08
Identities = 51/184 (27%), Positives = 78/184 (42%), Gaps = 20/184 (10%)
Query: 329 REAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKT 388
RE L+ L+E + GQ A + A+ N + + PL G +G GK
Sbjct: 58 REERPLNASALKLDLEEKLFGQHLATEVIFKALTGFRNN-KNPKKPLTLSLHGWAGTGKN 116
Query: 389 ELAKQTAKYMH-KDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLK--- 444
+++ A+ +H K K F+ L +S HE + QL K ++
Sbjct: 117 FVSQIVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKLYQD----------QLQKWIRGNV 166
Query: 445 -QCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIA 503
C N+V +FDE+DK HP ++ + D DG + + AIFI SN D I
Sbjct: 167 SACANSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDG----VSYRKAIFIFLSNAGGDLIT 222
Query: 504 QHAL 507
+ AL
Sbjct: 223 KTAL 226
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 56.2 bits (134), Expect = 1e-07
Identities = 59/213 (27%), Positives = 96/213 (45%), Gaps = 10/213 (4%)
Query: 111 AGLGMCALAAALVVHCYSKSPSNK--DAALLEAARANNMQEVSRLLSEGADVNAKHRLGW 168
A +G + + L+ H S + +N + AL AAR+ + V L+ +GA V AK +
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
Query: 169 TALMVAAINRNNSVVQVLLAAGADPNLG--DDFSSVYKTAKEQGIHSLEDGGQDGASRHI 226
T L ++A +VQ LL GA PN ++ ++ +A+E GAS I
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 227 TNQ--WTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKE 284
T + +T ++ L L+ ++ + + A G T LH A D+ +
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQK----SASPDAAGKSGLTPLHVAAHYDNQKVALL 616
Query: 285 LLDGGANPLQRNEMGHTPLDYAREGEVMKLLRT 317
LLD GA+P + G+TPL A + M + T
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATT 649
Score = 52.4 bits (124), Expect = 1e-06
Identities = 49/173 (28%), Positives = 81/173 (46%), Gaps = 10/173 (5%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNL- 195
AL A++ +++ VS LL A+V+A + G TAL +A++ VV+VL+ GA+ N
Sbjct: 77 ALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
Query: 196 -GDDFSSVYKTAKEQGIHSLEDGGQDGASRHI-TNQWTSALEFRRWLGLPAGVLITREDD 253
+ F+ +Y A+E + ++ +GAS+ + T + L G V + E+D
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEND 196
Query: 254 FNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
++ ALH A DD + LL N ++ G TPL A
Sbjct: 197 TKGKVR-------LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242
Score = 47.4 bits (111), Expect = 5e-05
Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 33/163 (20%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
AA +N + LL +GA +A + G+T L +AA + LL GAD N
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN------ 658
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNN 260
QGI S+ Q+G H+ +L+ R + N L+N
Sbjct: 659 ----AVTRQGIASVHLAAQEG---HVD---------------MVSLLLGRNANVN--LSN 694
Query: 261 RASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPL 303
++ G T LH A D + L++ GA+ + +MG+TPL
Sbjct: 695 KS---GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
Score = 45.1 bits (105), Expect = 2e-04
Identities = 51/212 (24%), Positives = 84/212 (39%), Gaps = 14/212 (6%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD--D 198
AA+ N M + LL GAD NA R G ++ +AA + +V +LL A+ NL +
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
+ ++ A+E ++ E GA H+ Q + L G N L
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGA--HVDAQTKMG-----YTPLHVGCHYGNIKIVNFLL 750
Query: 259 NNRASF-----KGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMK 313
+ A G T LH A + LL A+P + G+T L AR +
Sbjct: 751 QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYIS 810
Query: 314 LLRTSEAKYQEKQRKREAEERRRFPLEQRLKE 345
++ T + +E E+ + + + + E
Sbjct: 811 VVDTLKIVTEETMTTTTVTEKHKMNVPETMNE 842
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/206 (28%), Positives = 90/206 (43%), Gaps = 27/206 (13%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL A+ A + V L++ GA+VNA+ + G+T L +AA + VV+ LL GA +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 195 LGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDF 254
L A E G L Q G + ++ + + + + LPA + R+DD
Sbjct: 168 L----------ATEDGFTPLAVALQQGHDQVVSLLLEN--DTKGKVRLPALHIAARKDDT 215
Query: 255 --------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGA--NPLQRNEMGHTPLD 304
N+ + S G T LH A + LL+ A + RN++ TPL
Sbjct: 216 KAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI--TPLH 273
Query: 305 YARE---GEVMKLLRTSEAKYQEKQR 327
A + ++KLL AK K R
Sbjct: 274 VASKRGNANMVKLLLDRGAKIDAKTR 299
Score = 40.8 bits (94), Expect = 0.004
Identities = 44/170 (25%), Positives = 63/170 (37%), Gaps = 34/170 (20%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
A + N ++ + LL GA + A G T + VAA + ++V L+ GA PN
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN------ 460
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNN 260
E +H GQ R++ A V +DD
Sbjct: 461 -TTNVRGETALHMAARSGQAEVVRYLVQD-------------GAQVEAKAKDD------- 499
Query: 261 RASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREG 309
T LH + V++LL GA+P G+TPL AREG
Sbjct: 500 ------QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
Score = 39.3 bits (90), Expect = 0.013
Identities = 51/186 (27%), Positives = 73/186 (39%), Gaps = 36/186 (19%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
A++ N V LL GA ++AK R G T L A + + VV++LL D +
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL----------DRA 324
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNN 260
+ + + G+ L Q H+ + ++ +P DD N
Sbjct: 325 APILSKTKNGLSPLHMATQGD---HL-----NCVQLLLQHNVPV-------DDVTNDY-- 367
Query: 261 RASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA---REGEVMKLLRT 317
TALH A Y+ K LLD ANP + G TPL A +VM+LL
Sbjct: 368 ------LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
Query: 318 SEAKYQ 323
A Q
Sbjct: 422 HGASIQ 427
Score = 37.4 bits (85), Expect = 0.048
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 3/57 (5%)
Query: 262 ASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREG---EVMKLL 315
A+ KG TALH A LA VK L+ GAN +++ G TPL A + EV+K L
Sbjct: 103 ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
Score = 37.0 bits (84), Expect = 0.063
Identities = 43/166 (25%), Positives = 73/166 (43%), Gaps = 6/166 (3%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG--DD 198
A + +++ V LL V+ TAL VAA + V +VLL A+PN +
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGAS-RHITNQWTSALEFRRWLGLPAGVLITREDDFNNR 257
F+ ++ K+ I +E + GAS + +T + + ++G V I + +
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG---HVNIVSQLMHHGA 457
Query: 258 LNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPL 303
N + +G TALH A + V+ L+ GA + + TPL
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/184 (28%), Positives = 75/184 (40%), Gaps = 34/184 (18%)
Query: 126 CYSKSPSNKDAALLEAARANNMQEVSRLLSEG-ADVNAKHRLGWTALMVAAINRNNSVVQ 184
C + L AA+ N++ VS LLS G DVNA+ GWT ++ AA +++ V++
Sbjct: 709 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 768
Query: 185 VLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPA 244
+LL GAD L D+ +I W S F + A
Sbjct: 769 MLLTRGADVTLTDN------------------------EENICLHWAS---FTGSAAI-A 800
Query: 245 GVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLD 304
VL+ D + ++ G T LH A + V L GANP RN+ G T D
Sbjct: 801 EVLLNARCDL-----HAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWD 855
Query: 305 YARE 308
E
Sbjct: 856 LTPE 859
Score = 38.5 bits (88), Expect = 0.022
Identities = 56/229 (24%), Positives = 92/229 (40%), Gaps = 38/229 (16%)
Query: 93 GPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNK--DAALLEAARANNMQEV 150
GP TLP + V G G AL ALV+ + + L + + +Q+V
Sbjct: 573 GPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKV 632
Query: 151 SRLLSEGADVN--AKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKE 208
+L + D N + + T L AA + + VLL AGA+ N D K+
Sbjct: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVD---------KQ 683
Query: 209 QGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCT 268
Q +E + N + LE R++ G + ++E+D G T
Sbjct: 684 QRTPLME---------AVVN---NHLEVARYMVQRGGCVYSKEED------------GST 719
Query: 269 ALHYAVLADDYRTVKELLDGGANPLQRNEM-GHTPLDYAREGEVMKLLR 316
LH+A + V LL G + + G TP+ +A E + ++++R
Sbjct: 720 CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 768
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/184 (28%), Positives = 75/184 (40%), Gaps = 34/184 (18%)
Query: 126 CYSKSPSNKDAALLEAARANNMQEVSRLLSEG-ADVNAKHRLGWTALMVAAINRNNSVVQ 184
C + L AA+ N++ VS LLS G DVNA+ GWT ++ AA +++ V++
Sbjct: 743 CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 802
Query: 185 VLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPA 244
+LL GAD L D+ +I W S F + A
Sbjct: 803 MLLTRGADVTLTDN------------------------EENICLHWAS---FTGSAAI-A 834
Query: 245 GVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLD 304
VL+ D + ++ G T LH A + V L GANP RN+ G T D
Sbjct: 835 EVLLNARCDL-----HAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWD 889
Query: 305 YARE 308
E
Sbjct: 890 LTPE 893
Score = 38.5 bits (88), Expect = 0.022
Identities = 56/229 (24%), Positives = 92/229 (40%), Gaps = 38/229 (16%)
Query: 93 GPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNK--DAALLEAARANNMQEV 150
GP TLP + V G G AL ALV+ + + L + + +Q+V
Sbjct: 607 GPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKV 666
Query: 151 SRLLSEGADVN--AKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKE 208
+L + D N + + T L AA + + VLL AGA+ N D K+
Sbjct: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVD---------KQ 717
Query: 209 QGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCT 268
Q +E + N + LE R++ G + ++E+D G T
Sbjct: 718 QRTPLME---------AVVN---NHLEVARYMVQRGGCVYSKEED------------GST 753
Query: 269 ALHYAVLADDYRTVKELLDGGANPLQRNEM-GHTPLDYAREGEVMKLLR 316
LH+A + V LL G + + G TP+ +A E + ++++R
Sbjct: 754 CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIR 802
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 54.7 bits (130), Expect = 3e-07
Identities = 72/267 (26%), Positives = 110/267 (41%), Gaps = 47/267 (17%)
Query: 113 LGMCALAAALVVHCYSKSPSNKDA--ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTA 170
+G + AAL+ + +KD AL EA+ Q L+ GA+V AK++ G TA
Sbjct: 85 VGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTA 144
Query: 171 LMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQW 230
L +A N ++ +VLL AG+ +L ++ A + +H R + +
Sbjct: 145 LHLACQNSHSQSTRVLLLAGSRADLKNN-------AGDTCLHVAARYNHLSIIRLLLTAF 197
Query: 231 TSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGA 290
S E N+A G TALH A + + K LL+ GA
Sbjct: 198 CSVHE-----------------------KNQA---GDTALHVAAALNHKKVAKILLEAGA 231
Query: 291 NPLQRNEMGHTPLDYARE----------GEVMKLLRTSEAKYQEKQRKREAEERRRFPLE 340
+ N G TPL+ AR + ++LR S + K+R+R EERR +
Sbjct: 232 DTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVP 291
Query: 341 QRLKEHIIGQESAIATVGA--AIRRKE 365
+ G SA T + A+ RKE
Sbjct: 292 RDEVAQSKGSVSAGDTPSSEQAVARKE 318
Score = 43.5 bits (101), Expect = 7e-04
Identities = 53/196 (27%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD 197
LL AA + V +L+++GA V A + G T L +AA + VVQ+LL AG D ++ D
Sbjct: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 198 --DFSSVYKTAKEQGIHSLEDGGQDG-ASRHITNQWTSALEFRRWLGLPAGVLITREDDF 254
D +++++ + +G A +AL W G + +
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
Query: 255 NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA---REGEV 311
N N+A G TALH A ++ + LL G+ +N G T L A +
Sbjct: 133 NVLAKNKA---GNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSI 189
Query: 312 MKLLRTSEAKYQEKQR 327
++LL T+ EK +
Sbjct: 190 IRLLLTAFCSVHEKNQ 205
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 52.4 bits (124), Expect = 1e-06
Identities = 60/205 (29%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AA A + V L++ GA+VNA+ + G+T L +AA + VV+ LL GA+ N
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
Query: 195 LG-DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDD 253
+ +D + A +Q G + H+ N T + LPA + R DD
Sbjct: 172 VATEDGFTPLAVALQQ--------GHENVVAHLINYGTKGK-----VRLPALHIAARNDD 218
Query: 254 F--------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY 305
N+ + S G T LH A ++ + LL+ GA+ + G TPL
Sbjct: 219 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278
Query: 306 A-REGEV--MKLLRTSEAKYQEKQR 327
A R G V ++LL A+ + K +
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTK 303
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/335 (23%), Positives = 137/335 (40%), Gaps = 29/335 (8%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD--D 198
AARA + + LL A VNAK + T L AA + ++V++LL A+PNL
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRH-ITNQWTSALEFRRWLGLPAGVLITREDDFNNR 257
+ ++ A+E + ++ + AS+ +T + + L G + E D +
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH-- 594
Query: 258 LNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRT 317
N A G T LH AV ++ VK LL G +P G+TPL A + +++ R
Sbjct: 595 -PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR- 652
Query: 318 SEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVF 377
S +Y + PL H+ QE V + ++ NG + L
Sbjct: 653 SLLQYGGSANAESVQGVT--PL------HLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 704
Query: 378 LFLGSSGIGKTELAKQTAKY---MHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHE 434
L L + G +A K+ + + G+ L ++ ++ KF+ + H+
Sbjct: 705 LHLVAQE-GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL------LQHQ 757
Query: 435 EGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQ 469
KL P L + H D++T++L+
Sbjct: 758 ADVNAKTKLGYSP----LHQAAQQGHTDIVTLLLK 788
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/183 (27%), Positives = 79/183 (43%), Gaps = 7/183 (3%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA + + LL +GA N++ G+T L +A + V+++LL GA D
Sbjct: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
+ ++ + + +++ Q GAS +++N +E + AG + N+
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSN---VKVETPLHMAARAGHTEVAKYLLQNKA 494
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEVMKLLR 316
A K T LH A VK LL+ ANP GHTPL AREG V +L
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 554
Query: 317 TSE 319
E
Sbjct: 555 LLE 557
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-LGDDF 199
A+ N++ V LL ADVNAK +LG++ L AA + +V +LL GA PN + D
Sbjct: 741 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800
Query: 200 SSVYKTAKEQGIHSLED 216
++ AK G S+ D
Sbjct: 801 TTPLAIAKRLGYISVTD 817
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/173 (25%), Positives = 78/173 (45%), Gaps = 10/173 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDD-- 198
A++ +++ V LL + + + G TAL +AA+ + VV+ L+ GA+ N
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
F+ +Y A+E + ++ ++GA++++ + + L + E+ + +
Sbjct: 145 FTPLYMAAQENHLEVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLI 197
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
N K ALH A DD RT LL NP ++ G TPL A E
Sbjct: 198 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 250
Score = 39.7 bits (91), Expect = 0.010
Identities = 55/191 (28%), Positives = 77/191 (40%), Gaps = 29/191 (15%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA N+ LL+ GA VN + G T L +A+ N +V++LL GA + D+
Sbjct: 246 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305
Query: 199 FSSVYKTAKEQGIHSLE---DGG-------QDGASR-HITNQWTSALEFRRWLGLPAGVL 247
+ ++ A+ + E D G ++G S H+ Q R L A +
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI- 364
Query: 248 ITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA- 306
DD + T LH A +R K LLD GA P R G TPL A
Sbjct: 365 ----DDI--------TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 412
Query: 307 --REGEVMKLL 315
VM+LL
Sbjct: 413 KKNHVRVMELL 423
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 265 KGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREG---EVMKLL 315
KG TALH A LA V+EL++ GAN +++ G TPL A + EV+K L
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
Score = 37.0 bits (84), Expect = 0.063
Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 33/180 (18%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG 196
AL AAR ++ + + LL + + + G+T L +AA N +V Q+LL GA N
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 267
Query: 197 DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNN 256
+ GI L HI ++ + + R L A + +D+
Sbjct: 268 ---------TPQNGITPL----------HIASRRGNVIMVRLLLDRGAQIETKTKDEL-- 306
Query: 257 RLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLR 316
T LH A R + LLD GA + + G +P+ A +G+ + +R
Sbjct: 307 -----------TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 355
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 52.4 bits (124), Expect = 1e-06
Identities = 60/205 (29%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AA A + V L++ GA+VNA+ + G+T L +AA + VV+ LL GA+ N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 195 LG-DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDD 253
+ +D + A +Q G + H+ N T + LPA + R DD
Sbjct: 139 VATEDGFTPLAVALQQ--------GHENVVAHLINYGTKGK-----VRLPALHIAARNDD 185
Query: 254 F--------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY 305
N+ + S G T LH A ++ + LL+ GA+ + G TPL
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 306 A-REGEV--MKLLRTSEAKYQEKQR 327
A R G V ++LL A+ + K +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/335 (23%), Positives = 137/335 (40%), Gaps = 29/335 (8%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD--D 198
AARA + + LL A VNAK + T L AA + ++V++LL A+PNL
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRH-ITNQWTSALEFRRWLGLPAGVLITREDDFNNR 257
+ ++ A+E + ++ + AS+ +T + + L G + E D +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH-- 561
Query: 258 LNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRT 317
N A G T LH AV ++ VK LL G +P G+TPL A + +++ R
Sbjct: 562 -PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR- 619
Query: 318 SEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVF 377
S +Y + PL H+ QE V + ++ NG + L
Sbjct: 620 SLLQYGGSANAESVQGVT--PL------HLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Query: 378 LFLGSSGIGKTELAKQTAKY---MHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHE 434
L L + G +A K+ + + G+ L ++ ++ KF+ + H+
Sbjct: 672 LHLVAQE-GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL------LQHQ 724
Query: 435 EGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQ 469
KL P L + H D++T++L+
Sbjct: 725 ADVNAKTKLGYSP----LHQAAQQGHTDIVTLLLK 755
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/183 (27%), Positives = 79/183 (43%), Gaps = 7/183 (3%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA + + LL +GA N++ G+T L +A + V+++LL GA D
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
+ ++ + + +++ Q GAS +++N +E + AG + N+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSN---VKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEVMKLLR 316
A K T LH A VK LL+ ANP GHTPL AREG V +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 317 TSE 319
E
Sbjct: 522 LLE 524
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-LGDDF 199
A+ N++ V LL ADVNAK +LG++ L AA + +V +LL GA PN + D
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 200 SSVYKTAKEQGIHSLED 216
++ AK G S+ D
Sbjct: 768 TTPLAIAKRLGYISVTD 784
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/173 (25%), Positives = 78/173 (45%), Gaps = 10/173 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDD-- 198
A++ +++ V LL + + + G TAL +AA+ + VV+ L+ GA+ N
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
F+ +Y A+E + ++ ++GA++++ + + L + E+ + +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLI 164
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
N K ALH A DD RT LL NP ++ G TPL A E
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Score = 39.7 bits (91), Expect = 0.010
Identities = 55/191 (28%), Positives = 77/191 (40%), Gaps = 29/191 (15%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA N+ LL+ GA VN + G T L +A+ N +V++LL GA + D+
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 199 FSSVYKTAKEQGIHSLE---DGG-------QDGASR-HITNQWTSALEFRRWLGLPAGVL 247
+ ++ A+ + E D G ++G S H+ Q R L A +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI- 331
Query: 248 ITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA- 306
DD + T LH A +R K LLD GA P R G TPL A
Sbjct: 332 ----DDI--------TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 307 --REGEVMKLL 315
VM+LL
Sbjct: 380 KKNHVRVMELL 390
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 265 KGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREG---EVMKLL 315
KG TALH A LA V+EL++ GAN +++ G TPL A + EV+K L
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 37.0 bits (84), Expect = 0.063
Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 33/180 (18%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG 196
AL AAR ++ + + LL + + + G+T L +AA N +V Q+LL GA N
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
Query: 197 DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNN 256
+ GI L HI ++ + + R L A + +D+
Sbjct: 235 ---------TPQNGITPL----------HIASRRGNVIMVRLLLDRGAQIETKTKDEL-- 273
Query: 257 RLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLR 316
T LH A R + LLD GA + + G +P+ A +G+ + +R
Sbjct: 274 -----------TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 52.4 bits (124), Expect = 1e-06
Identities = 60/205 (29%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AA A + V L++ GA+VNA+ + G+T L +AA + VV+ LL GA+ N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 195 LG-DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDD 253
+ +D + A +Q G + H+ N T + LPA + R DD
Sbjct: 139 VATEDGFTPLAVALQQ--------GHENVVAHLINYGTKGK-----VRLPALHIAARNDD 185
Query: 254 F--------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY 305
N+ + S G T LH A ++ + LL+ GA+ + G TPL
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 306 A-REGEV--MKLLRTSEAKYQEKQR 327
A R G V ++LL A+ + K +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/335 (23%), Positives = 137/335 (40%), Gaps = 29/335 (8%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD--D 198
AARA + + LL A VNAK + T L AA + ++V++LL A+PNL
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRH-ITNQWTSALEFRRWLGLPAGVLITREDDFNNR 257
+ ++ A+E + ++ + AS+ +T + + L G + E D +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH-- 561
Query: 258 LNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRT 317
N A G T LH AV ++ VK LL G +P G+TPL A + +++ R
Sbjct: 562 -PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR- 619
Query: 318 SEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVF 377
S +Y + PL H+ QE V + ++ NG + L
Sbjct: 620 SLLQYGGSANAESVQGVT--PL------HLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Query: 378 LFLGSSGIGKTELAKQTAKY---MHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHE 434
L L + G +A K+ + + G+ L ++ ++ KF+ + H+
Sbjct: 672 LHLVAQE-GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL------LQHQ 724
Query: 435 EGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQ 469
KL P L + H D++T++L+
Sbjct: 725 ADVNAKTKLGYSP----LHQAAQQGHTDIVTLLLK 755
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/183 (27%), Positives = 79/183 (43%), Gaps = 7/183 (3%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA + + LL +GA N++ G+T L +A + V+++LL GA D
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
+ ++ + + +++ Q GAS +++N +E + AG + N+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSN---VKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEVMKLLR 316
A K T LH A VK LL+ ANP GHTPL AREG V +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 317 TSE 319
E
Sbjct: 522 LLE 524
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-LGDDF 199
A+ N++ V LL ADVNAK +LG++ L AA + +V +LL GA PN + D
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 200 SSVYKTAKEQGIHSLED 216
++ AK G S+ D
Sbjct: 768 TTPLAIAKRLGYISVTD 784
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/173 (25%), Positives = 78/173 (45%), Gaps = 10/173 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDD-- 198
A++ +++ V LL + + + G TAL +AA+ + VV+ L+ GA+ N
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
F+ +Y A+E + ++ ++GA++++ + + L + E+ + +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLI 164
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
N K ALH A DD RT LL NP ++ G TPL A E
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Score = 39.7 bits (91), Expect = 0.010
Identities = 55/191 (28%), Positives = 77/191 (40%), Gaps = 29/191 (15%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA N+ LL+ GA VN + G T L +A+ N +V++LL GA + D+
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 199 FSSVYKTAKEQGIHSLE---DGG-------QDGASR-HITNQWTSALEFRRWLGLPAGVL 247
+ ++ A+ + E D G ++G S H+ Q R L A +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI- 331
Query: 248 ITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA- 306
DD + T LH A +R K LLD GA P R G TPL A
Sbjct: 332 ----DDI--------TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 307 --REGEVMKLL 315
VM+LL
Sbjct: 380 KKNHVRVMELL 390
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 265 KGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREG---EVMKLL 315
KG TALH A LA V+EL++ GAN +++ G TPL A + EV+K L
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 37.0 bits (84), Expect = 0.063
Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 33/180 (18%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG 196
AL AAR ++ + + LL + + + G+T L +AA N +V Q+LL GA N
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
Query: 197 DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNN 256
+ GI L HI ++ + + R L A + +D+
Sbjct: 235 ---------TPQNGITPL----------HIASRRGNVIMVRLLLDRGAQIETKTKDEL-- 273
Query: 257 RLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLR 316
T LH A R + LLD GA + + G +P+ A +G+ + +R
Sbjct: 274 -----------TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 52.4 bits (124), Expect = 1e-06
Identities = 60/205 (29%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AA A + V L++ GA+VNA+ + G+T L +AA + VV+ LL GA+ N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 195 LG-DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDD 253
+ +D + A +Q G + H+ N T + LPA + R DD
Sbjct: 139 VATEDGFTPLAVALQQ--------GHENVVAHLINYGTKGK-----VRLPALHIAARNDD 185
Query: 254 F--------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY 305
N+ + S G T LH A ++ + LL+ GA+ + G TPL
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 306 A-REGEV--MKLLRTSEAKYQEKQR 327
A R G V ++LL A+ + K +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/335 (23%), Positives = 137/335 (40%), Gaps = 29/335 (8%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD--D 198
AARA + + LL A VNAK + T L AA + ++V++LL A+PNL
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRH-ITNQWTSALEFRRWLGLPAGVLITREDDFNNR 257
+ ++ A+E + ++ + AS+ +T + + L G + E D +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH-- 561
Query: 258 LNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRT 317
N A G T LH AV ++ VK LL G +P G+TPL A + +++ R
Sbjct: 562 -PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR- 619
Query: 318 SEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVF 377
S +Y + PL H+ QE V + ++ NG + L
Sbjct: 620 SLLQYGGSANAESVQGVT--PL------HLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Query: 378 LFLGSSGIGKTELAKQTAKY---MHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHE 434
L L + G +A K+ + + G+ L ++ ++ KF+ + H+
Sbjct: 672 LHLVAQE-GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL------LQHQ 724
Query: 435 EGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQ 469
KL P L + H D++T++L+
Sbjct: 725 ADVNAKTKLGYSP----LHQAAQQGHTDIVTLLLK 755
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/183 (27%), Positives = 79/183 (43%), Gaps = 7/183 (3%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA + + LL +GA N++ G+T L +A + V+++LL GA D
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
+ ++ + + +++ Q GAS +++N +E + AG + N+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSN---VKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEVMKLLR 316
A K T LH A VK LL+ ANP GHTPL AREG V +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 317 TSE 319
E
Sbjct: 522 LLE 524
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-LGDDF 199
A+ N++ V LL ADVNAK +LG++ L AA + +V +LL GA PN + D
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 200 SSVYKTAKEQGIHSLED 216
++ AK G S+ D
Sbjct: 768 TTPLAIAKRLGYISVTD 784
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/173 (25%), Positives = 78/173 (45%), Gaps = 10/173 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDD-- 198
A++ +++ V LL + + + G TAL +AA+ + VV+ L+ GA+ N
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
F+ +Y A+E + ++ ++GA++++ + + L + E+ + +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLI 164
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
N K ALH A DD RT LL NP ++ G TPL A E
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Score = 39.7 bits (91), Expect = 0.010
Identities = 55/191 (28%), Positives = 77/191 (40%), Gaps = 29/191 (15%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA N+ LL+ GA VN + G T L +A+ N +V++LL GA + D+
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 199 FSSVYKTAKEQGIHSLE---DGG-------QDGASR-HITNQWTSALEFRRWLGLPAGVL 247
+ ++ A+ + E D G ++G S H+ Q R L A +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI- 331
Query: 248 ITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA- 306
DD + T LH A +R K LLD GA P R G TPL A
Sbjct: 332 ----DDI--------TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 307 --REGEVMKLL 315
VM+LL
Sbjct: 380 KKNHVRVMELL 390
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 265 KGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREG---EVMKLL 315
KG TALH A LA V+EL++ GAN +++ G TPL A + EV+K L
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 37.0 bits (84), Expect = 0.063
Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 33/180 (18%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG 196
AL AAR ++ + + LL + + + G+T L +AA N +V Q+LL GA N
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
Query: 197 DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNN 256
+ GI L HI ++ + + R L A + +D+
Sbjct: 235 ---------TPQNGITPL----------HIASRRGNVIMVRLLLDRGAQIETKTKDEL-- 273
Query: 257 RLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLR 316
T LH A R + LLD GA + + G +P+ A +G+ + +R
Sbjct: 274 -----------TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 52.4 bits (124), Expect = 1e-06
Identities = 60/205 (29%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AA A + V L++ GA+VNA+ + G+T L +AA + VV+ LL GA+ N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 195 LG-DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDD 253
+ +D + A +Q G + H+ N T + LPA + R DD
Sbjct: 139 VATEDGFTPLAVALQQ--------GHENVVAHLINYGTKGK-----VRLPALHIAARNDD 185
Query: 254 F--------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY 305
N+ + S G T LH A ++ + LL+ GA+ + G TPL
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 306 A-REGEV--MKLLRTSEAKYQEKQR 327
A R G V ++LL A+ + K +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/335 (23%), Positives = 137/335 (40%), Gaps = 29/335 (8%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD--D 198
AARA + + LL A VNAK + T L AA + ++V++LL A+PNL
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRH-ITNQWTSALEFRRWLGLPAGVLITREDDFNNR 257
+ ++ A+E + ++ + AS+ +T + + L G + E D +
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH-- 561
Query: 258 LNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRT 317
N A G T LH AV ++ VK LL G +P G+TPL A + +++ R
Sbjct: 562 -PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR- 619
Query: 318 SEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVF 377
S +Y + PL H+ QE V + ++ NG + L
Sbjct: 620 SLLQYGGSANAESVQGVT--PL------HLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671
Query: 378 LFLGSSGIGKTELAKQTAKY---MHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHE 434
L L + G +A K+ + + G+ L ++ ++ KF+ + H+
Sbjct: 672 LHLVAQE-GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL------LQHQ 724
Query: 435 EGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQ 469
KL P L + H D++T++L+
Sbjct: 725 ADVNAKTKLGYSP----LHQAAQQGHTDIVTLLLK 755
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/183 (27%), Positives = 79/183 (43%), Gaps = 7/183 (3%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA + + LL +GA N++ G+T L +A + V+++LL GA D
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
+ ++ + + +++ Q GAS +++N +E + AG + N+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSN---VKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEVMKLLR 316
A K T LH A VK LL+ ANP GHTPL AREG V +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 317 TSE 319
E
Sbjct: 522 LLE 524
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-LGDDF 199
A+ N++ V LL ADVNAK +LG++ L AA + +V +LL GA PN + D
Sbjct: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 200 SSVYKTAKEQGIHSLED 216
++ AK G S+ D
Sbjct: 768 TTPLAIAKRLGYISVTD 784
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/173 (25%), Positives = 78/173 (45%), Gaps = 10/173 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDD-- 198
A++ +++ V LL + + + G TAL +AA+ + VV+ L+ GA+ N
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRL 258
F+ +Y A+E + ++ ++GA++++ + + L + E+ + +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLI 164
Query: 259 NNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
N K ALH A DD RT LL NP ++ G TPL A E
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYE 217
Score = 39.7 bits (91), Expect = 0.010
Identities = 55/191 (28%), Positives = 77/191 (40%), Gaps = 29/191 (15%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA--DPNLGDD 198
AA N+ LL+ GA VN + G T L +A+ N +V++LL GA + D+
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 199 FSSVYKTAKEQGIHSLE---DGG-------QDGASR-HITNQWTSALEFRRWLGLPAGVL 247
+ ++ A+ + E D G ++G S H+ Q R L A +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI- 331
Query: 248 ITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA- 306
DD + T LH A +R K LLD GA P R G TPL A
Sbjct: 332 ----DDI--------TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIAC 379
Query: 307 --REGEVMKLL 315
VM+LL
Sbjct: 380 KKNHVRVMELL 390
Score = 38.5 bits (88), Expect = 0.022
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 265 KGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREG---EVMKLL 315
KG TALH A LA V+EL++ GAN +++ G TPL A + EV+K L
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Score = 37.0 bits (84), Expect = 0.063
Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 33/180 (18%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG 196
AL AAR ++ + + LL + + + G+T L +AA N +V Q+LL GA N
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
Query: 197 DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNN 256
+ GI L HI ++ + + R L A + +D+
Sbjct: 235 ---------TPQNGITPL----------HIASRRGNVIMVRLLLDRGAQIETKTKDEL-- 273
Query: 257 RLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLR 316
T LH A R + LLD GA + + G +P+ A +G+ + +R
Sbjct: 274 -----------TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
>gi|47933348 zinc finger, DHHC domain containing 13 isoform 2 [Homo
sapiens]
Length = 492
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/157 (32%), Positives = 75/157 (47%), Gaps = 14/157 (8%)
Query: 182 VVQVLLAAGADPNL--GDDFSSVYKTAKEQG---IHSLEDGGQDGASRHITNQWTSALEF 236
+V +LL GADP L G+ FSS++ Q I L GQ + Q L
Sbjct: 1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSA 60
Query: 237 RRWLGL-PAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQR 295
+ +G P G L+ FN LN T LH+AV A + V +LL+ G++ +
Sbjct: 61 HKVIGPEPTGFLLK----FNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQ 116
Query: 296 NEMGHTPLDYAREGE---VMKLLRTSEAKYQEKQRKR 329
N G TPLD A + + ++ +L+T EAK + Q+ R
Sbjct: 117 NVKGETPLDMALQNKNQLIIHMLKT-EAKMRANQKFR 152
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 51.6 bits (122), Expect = 2e-06
Identities = 28/60 (46%), Positives = 39/60 (65%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD 197
L ++A AN+++ V +LL +GAD A G TAL A+ N N+ +VQ+LL GADPN D
Sbjct: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
Score = 40.8 bits (94), Expect = 0.004
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 262 ASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
A KG TALH+A + + V+ LLD GA+P QR+ +G+TPL A
Sbjct: 139 ADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
Score = 32.3 bits (72), Expect = 1.6
Identities = 26/99 (26%), Positives = 39/99 (39%), Gaps = 2/99 (2%)
Query: 210 GIHSLEDGGQDGASRHITNQWTSALEFRRWLG--LPAGVLITREDDFNNRLNNRASFKGC 267
G+ GG R++ W E R L +PAG L
Sbjct: 52 GLSGRASGGAQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHAL 111
Query: 268 TALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
L + A+D TV++LL+ GA+P ++ G T L +A
Sbjct: 112 KRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFA 150
>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
sapiens]
Length = 950
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/229 (27%), Positives = 91/229 (39%), Gaps = 39/229 (17%)
Query: 138 LLEAARANNMQEVSRLLSEGA------DVNAKHR----LGWTALMVAAINRNNSVVQVLL 187
LL AR N +EV +LL A D+N K R LGWT L +A + VVQ LL
Sbjct: 9 LLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLL 68
Query: 188 AAGADPNLGDDFS------SVYKTAKEQGIHSLEDGGQD---GASRHITNQWTSALEFRR 238
AGA+ N+ +D + + KE + LE S + T A E R
Sbjct: 69 KAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRS 128
Query: 239 WLG-------------LPAGVLITREDDFNNRLN-------NRASFKGCTALHYAVLADD 278
L L A + + LN N + G T LH A
Sbjct: 129 MLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAH 188
Query: 279 YRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQR 327
+ +LL GA+P +N+ PLD A+ E+ +L ++ Y+ +R
Sbjct: 189 KQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKR 237
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 50.1 bits (118), Expect = 7e-06
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 8/187 (4%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AARA ++ V LL GA V+A+ R T L +A+ +VQ+LL A P+
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
Query: 195 LG--DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQ--WTSALEFRRWLGLPAGVLITR 250
+ ++ ++ +A+E + + GA+ + + +T ++ L L+ +
Sbjct: 504 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
Query: 251 EDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
+ A G T LH A D+ + LL+ GA+P + G+TPL A +
Sbjct: 564 R----RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 619
Query: 311 VMKLLRT 317
M++ T
Sbjct: 620 QMQIAST 626
Score = 49.7 bits (117), Expect = 9e-06
Identities = 53/175 (30%), Positives = 72/175 (41%), Gaps = 33/175 (18%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA 191
S+ +A+ L AARA N+ +V L G D+N ++ G AL +AA + +VQ LL G
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG- 66
Query: 192 DPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITRE 251
SSV D A T + +AL G V + +
Sbjct: 67 --------SSV-----------------DSA----TKKGNTALHIASLAGQAEVVKVLVK 97
Query: 252 DDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
+ N N S G T L+ A + VK LL+ GAN E G TPL A
Sbjct: 98 EGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149
Score = 46.6 bits (109), Expect = 8e-05
Identities = 72/274 (26%), Positives = 108/274 (39%), Gaps = 41/274 (14%)
Query: 83 LAAATWGRLPGPEETLPG--------QDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNK 134
L AA G L E L G Q+ N + A G L L+ S + K
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 135 --DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGAD 192
+ AL A+ A + V L+ EGA++NA+ + G+T L +AA + VV+ LL GA+
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 193 PNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITRED 252
+ TA E G L Q G ++ + + + + + LPA + R+D
Sbjct: 135 QS----------TATEDGFTPLAVALQQGHNQAVAILLEN--DTKGKVRLPALHIAARKD 182
Query: 253 DF----------------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRN 296
D + + NR + G T LH A + LL+ GA
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 242
Query: 297 EMGHTPLDYARE---GEVMKLLRTSEAKYQEKQR 327
G TPL A + ++KLL + K R
Sbjct: 243 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 276
Score = 44.3 bits (103), Expect = 4e-04
Identities = 48/175 (27%), Positives = 67/175 (38%), Gaps = 33/175 (18%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
A++ N V LL G ++AK R G T L AA + ++ VV++LL GA P L +
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 310
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNN 260
+ +H G +H+ DD
Sbjct: 311 GL------SPLHMAAQGDHVECVKHLLQHKAPV------------------DD------- 339
Query: 261 RASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL 315
+ TALH A YR K LLD ANP R G TPL A + +K++
Sbjct: 340 -VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 393
Score = 44.3 bits (103), Expect = 4e-04
Identities = 24/57 (42%), Positives = 35/57 (61%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
L+ A N++ V+ LL +GA+VNAK + G+T L AA + ++ VLL GA PN
Sbjct: 711 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/189 (24%), Positives = 83/189 (43%), Gaps = 10/189 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG--DD 198
AA+ N MQ S LL+ GA+ N + G T L +A+ + +V +LL GA+ ++
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASR--HITNQWTSALEFRRWLGLP-AGVLITREDDFN 255
+S++ A+E ++ + + GA + H +T + + + L+ + + N
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 734
Query: 256 NRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL 315
+ N G T LH A + LL GA P G+T L A+ + ++
Sbjct: 735 AKTKN-----GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
Query: 316 RTSEAKYQE 324
T + +E
Sbjct: 790 DTLKVVTEE 798
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/178 (26%), Positives = 73/178 (41%), Gaps = 20/178 (11%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
AA +N + LL +GA +A + G+T L +AA + LL GA+ N+
Sbjct: 582 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI----- 636
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSA--LEFRRWLGLPAGVLITREDDFN--- 255
+QG+ L Q+G + +T + GL + L +ED N
Sbjct: 637 -----VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 691
Query: 256 ----NRLNNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYARE 308
+ + A K G T L A + + V LL GAN + + G+TPL A +
Sbjct: 692 ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 749
Score = 34.7 bits (78), Expect = 0.31
Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 7/179 (3%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-- 194
AL AA + + LL + A+ NA+ G+T L +A V+++L+ GA
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
Query: 195 LGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITN-QWTSALEFRRWLGLPAGVLITREDD 253
+ ++ A ++ + Q+GAS +TN + +AL G V + R
Sbjct: 407 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG---QVEVVRCLL 463
Query: 254 FNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEV 311
N L + + + T LH A V+ LL A+P G+TPL AREG+V
Sbjct: 464 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 522
Score = 33.5 bits (75), Expect = 0.70
Identities = 46/193 (23%), Positives = 79/193 (40%), Gaps = 39/193 (20%)
Query: 124 VHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVV 183
+H ++ K AALL +N S+++ VN G+T L +AA N +V
Sbjct: 175 LHIAARKDDTKSAALL-LQNDHNADVQSKMM-----VNRTTESGFTPLHIAAHYGNVNVA 228
Query: 184 QVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLP 243
+LL GA DF++ GI L + G + +
Sbjct: 229 TLLLNRGA----AVDFTA------RNGITPLHVASKRGNTNMVK---------------- 262
Query: 244 AGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPL 303
+L+ R + + + G T LH A + + V+ LL+ GA L R + G +PL
Sbjct: 263 --LLLDRGGQIDAKTRD-----GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315
Query: 304 DYAREGEVMKLLR 316
A +G+ ++ ++
Sbjct: 316 HMAAQGDHVECVK 328
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 50.1 bits (118), Expect = 7e-06
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 8/187 (4%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AARA ++ V LL GA V+A+ R T L +A+ +VQ+LL A P+
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 195 LG--DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQ--WTSALEFRRWLGLPAGVLITR 250
+ ++ ++ +A+E + + GA+ + + +T ++ L L+ +
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Query: 251 EDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
+ A G T LH A D+ + LL+ GA+P + G+TPL A +
Sbjct: 585 R----RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640
Query: 311 VMKLLRT 317
M++ T
Sbjct: 641 QMQIAST 647
Score = 49.7 bits (117), Expect = 9e-06
Identities = 53/175 (30%), Positives = 72/175 (41%), Gaps = 33/175 (18%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA 191
S+ +A+ L AARA N+ +V L G D+N ++ G AL +AA + +VQ LL G
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG- 87
Query: 192 DPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITRE 251
SSV D A T + +AL G V + +
Sbjct: 88 --------SSV-----------------DSA----TKKGNTALHIASLAGQAEVVKVLVK 118
Query: 252 DDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
+ N N S G T L+ A + VK LL+ GAN E G TPL A
Sbjct: 119 EGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Score = 46.6 bits (109), Expect = 8e-05
Identities = 72/274 (26%), Positives = 108/274 (39%), Gaps = 41/274 (14%)
Query: 83 LAAATWGRLPGPEETLPG--------QDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNK 134
L AA G L E L G Q+ N + A G L L+ S + K
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 135 --DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGAD 192
+ AL A+ A + V L+ EGA++NA+ + G+T L +AA + VV+ LL GA+
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 193 PNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITRED 252
+ TA E G L Q G ++ + + + + + LPA + R+D
Sbjct: 156 QS----------TATEDGFTPLAVALQQGHNQAVAILLEN--DTKGKVRLPALHIAARKD 203
Query: 253 DF----------------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRN 296
D + + NR + G T LH A + LL+ GA
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 297 EMGHTPLDYARE---GEVMKLLRTSEAKYQEKQR 327
G TPL A + ++KLL + K R
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 297
Score = 44.3 bits (103), Expect = 4e-04
Identities = 48/175 (27%), Positives = 67/175 (38%), Gaps = 33/175 (18%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
A++ N V LL G ++AK R G T L AA + ++ VV++LL GA P L +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 331
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNN 260
+ +H G +H+ DD
Sbjct: 332 GL------SPLHMAAQGDHVECVKHLLQHKAPV------------------DD------- 360
Query: 261 RASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL 315
+ TALH A YR K LLD ANP R G TPL A + +K++
Sbjct: 361 -VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Score = 44.3 bits (103), Expect = 4e-04
Identities = 24/57 (42%), Positives = 35/57 (61%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
L+ A N++ V+ LL +GA+VNAK + G+T L AA + ++ VLL GA PN
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/189 (24%), Positives = 83/189 (43%), Gaps = 10/189 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG--DD 198
AA+ N MQ S LL+ GA+ N + G T L +A+ + +V +LL GA+ ++
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASR--HITNQWTSALEFRRWLGLP-AGVLITREDDFN 255
+S++ A+E ++ + + GA + H +T + + + L+ + + N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 256 NRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL 315
+ N G T LH A + LL GA P G+T L A+ + ++
Sbjct: 756 AKTKN-----GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 316 RTSEAKYQE 324
T + +E
Sbjct: 811 DTLKVVTEE 819
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/178 (26%), Positives = 73/178 (41%), Gaps = 20/178 (11%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
AA +N + LL +GA +A + G+T L +AA + LL GA+ N+
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI----- 657
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSA--LEFRRWLGLPAGVLITREDDFN--- 255
+QG+ L Q+G + +T + GL + L +ED N
Sbjct: 658 -----VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 712
Query: 256 ----NRLNNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYARE 308
+ + A K G T L A + + V LL GAN + + G+TPL A +
Sbjct: 713 ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 770
Score = 34.7 bits (78), Expect = 0.31
Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 7/179 (3%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-- 194
AL AA + + LL + A+ NA+ G+T L +A V+++L+ GA
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 195 LGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITN-QWTSALEFRRWLGLPAGVLITREDD 253
+ ++ A ++ + Q+GAS +TN + +AL G V + R
Sbjct: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG---QVEVVRCLL 484
Query: 254 FNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEV 311
N L + + + T LH A V+ LL A+P G+TPL AREG+V
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
Score = 33.5 bits (75), Expect = 0.70
Identities = 46/193 (23%), Positives = 79/193 (40%), Gaps = 39/193 (20%)
Query: 124 VHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVV 183
+H ++ K AALL +N S+++ VN G+T L +AA N +V
Sbjct: 196 LHIAARKDDTKSAALL-LQNDHNADVQSKMM-----VNRTTESGFTPLHIAAHYGNVNVA 249
Query: 184 QVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLP 243
+LL GA DF++ GI L + G + +
Sbjct: 250 TLLLNRGA----AVDFTA------RNGITPLHVASKRGNTNMVK---------------- 283
Query: 244 AGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPL 303
+L+ R + + + G T LH A + + V+ LL+ GA L R + G +PL
Sbjct: 284 --LLLDRGGQIDAKTRD-----GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 304 DYAREGEVMKLLR 316
A +G+ ++ ++
Sbjct: 337 HMAAQGDHVECVK 349
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 50.1 bits (118), Expect = 7e-06
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 8/187 (4%)
Query: 135 DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
+ AL AARA ++ V LL GA V+A+ R T L +A+ +VQ+LL A P+
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 195 LG--DDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQ--WTSALEFRRWLGLPAGVLITR 250
+ ++ ++ +A+E + + GA+ + + +T ++ L L+ +
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Query: 251 EDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
+ A G T LH A D+ + LL+ GA+P + G+TPL A +
Sbjct: 585 R----RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640
Query: 311 VMKLLRT 317
M++ T
Sbjct: 641 QMQIAST 647
Score = 49.7 bits (117), Expect = 9e-06
Identities = 53/175 (30%), Positives = 72/175 (41%), Gaps = 33/175 (18%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA 191
S+ +A+ L AARA N+ +V L G D+N ++ G AL +AA + +VQ LL G
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG- 87
Query: 192 DPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITRE 251
SSV D A T + +AL G V + +
Sbjct: 88 --------SSV-----------------DSA----TKKGNTALHIASLAGQAEVVKVLVK 118
Query: 252 DDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
+ N N S G T L+ A + VK LL+ GAN E G TPL A
Sbjct: 119 EGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Score = 46.6 bits (109), Expect = 8e-05
Identities = 72/274 (26%), Positives = 108/274 (39%), Gaps = 41/274 (14%)
Query: 83 LAAATWGRLPGPEETLPG--------QDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNK 134
L AA G L E L G Q+ N + A G L L+ S + K
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 135 --DAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGAD 192
+ AL A+ A + V L+ EGA++NA+ + G+T L +AA + VV+ LL GA+
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 193 PNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITRED 252
+ TA E G L Q G ++ + + + + + LPA + R+D
Sbjct: 156 QS----------TATEDGFTPLAVALQQGHNQAVAILLEN--DTKGKVRLPALHIAARKD 203
Query: 253 DF----------------NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRN 296
D + + NR + G T LH A + LL+ GA
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 297 EMGHTPLDYARE---GEVMKLLRTSEAKYQEKQR 327
G TPL A + ++KLL + K R
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 297
Score = 44.3 bits (103), Expect = 4e-04
Identities = 48/175 (27%), Positives = 67/175 (38%), Gaps = 33/175 (18%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
A++ N V LL G ++AK R G T L AA + ++ VV++LL GA P L +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 331
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNN 260
+ +H G +H+ DD
Sbjct: 332 GL------SPLHMAAQGDHVECVKHLLQHKAPV------------------DD------- 360
Query: 261 RASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL 315
+ TALH A YR K LLD ANP R G TPL A + +K++
Sbjct: 361 -VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Score = 44.3 bits (103), Expect = 4e-04
Identities = 24/57 (42%), Positives = 35/57 (61%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN 194
L+ A N++ V+ LL +GA+VNAK + G+T L AA + ++ VLL GA PN
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/189 (24%), Positives = 83/189 (43%), Gaps = 10/189 (5%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG--DD 198
AA+ N MQ S LL+ GA+ N + G T L +A+ + +V +LL GA+ ++
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 199 FSSVYKTAKEQGIHSLEDGGQDGASR--HITNQWTSALEFRRWLGLP-AGVLITREDDFN 255
+S++ A+E ++ + + GA + H +T + + + L+ + + N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 256 NRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL 315
+ N G T LH A + LL GA P G+T L A+ + ++
Sbjct: 756 AKTKN-----GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 316 RTSEAKYQE 324
T + +E
Sbjct: 811 DTLKVVTEE 819
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/178 (26%), Positives = 73/178 (41%), Gaps = 20/178 (11%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
AA +N + LL +GA +A + G+T L +AA + LL GA+ N+
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI----- 657
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSA--LEFRRWLGLPAGVLITREDDFN--- 255
+QG+ L Q+G + +T + GL + L +ED N
Sbjct: 658 -----VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 712
Query: 256 ----NRLNNRASFK-GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYARE 308
+ + A K G T L A + + V LL GAN + + G+TPL A +
Sbjct: 713 ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ 770
Score = 34.7 bits (78), Expect = 0.31
Identities = 49/179 (27%), Positives = 78/179 (43%), Gaps = 7/179 (3%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPN-- 194
AL AA + + LL + A+ NA+ G+T L +A V+++L+ GA
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 195 LGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITN-QWTSALEFRRWLGLPAGVLITREDD 253
+ ++ A ++ + Q+GAS +TN + +AL G V + R
Sbjct: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG---QVEVVRCLL 484
Query: 254 FNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY-AREGEV 311
N L + + + T LH A V+ LL A+P G+TPL AREG+V
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
Score = 33.5 bits (75), Expect = 0.70
Identities = 46/193 (23%), Positives = 79/193 (40%), Gaps = 39/193 (20%)
Query: 124 VHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVV 183
+H ++ K AALL +N S+++ VN G+T L +AA N +V
Sbjct: 196 LHIAARKDDTKSAALL-LQNDHNADVQSKMM-----VNRTTESGFTPLHIAAHYGNVNVA 249
Query: 184 QVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLP 243
+LL GA DF++ GI L + G + +
Sbjct: 250 TLLLNRGA----AVDFTA------RNGITPLHVASKRGNTNMVK---------------- 283
Query: 244 AGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPL 303
+L+ R + + + G T LH A + + V+ LL+ GA L R + G +PL
Sbjct: 284 --LLLDRGGQIDAKTRD-----GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 304 DYAREGEVMKLLR 316
A +G+ ++ ++
Sbjct: 337 HMAAQGDHVECVK 349
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 49.7 bits (117), Expect = 9e-06
Identities = 75/289 (25%), Positives = 120/289 (41%), Gaps = 22/289 (7%)
Query: 136 AALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNL 195
+AL++AAR ++ LL GADVNA++RLG + L VA+ + VV++LL AGA
Sbjct: 113 SALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGA---- 168
Query: 196 GDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFN 255
F + + EQ L GG IT AL G A V + E +
Sbjct: 169 ---FVDHHHPSGEQ----LGLGGSRDEPLDIT-----ALMAAIQHGHEAVVRLLME--WG 214
Query: 256 NRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL 315
N+ A G + L A L ++L++ GANP + + T + A + + L+
Sbjct: 215 ADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLV 274
Query: 316 RTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPL 375
+ R + EE+RR + LK IA + NG D PL
Sbjct: 275 DYLDP--LTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNG--DGATPL 330
Query: 376 VFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFI 424
+ + L ++ A +D+ G+ L + + E+ K++
Sbjct: 331 MLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYL 379
Score = 46.6 bits (109), Expect = 8e-05
Identities = 37/105 (35%), Positives = 50/105 (47%), Gaps = 5/105 (4%)
Query: 108 PSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLG 167
P A G A+ A + V C S + AL AA + V LL GA VN+++ G
Sbjct: 57 PGAAAAG--AVGAPVPVDC---SDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYG 111
Query: 168 WTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIH 212
W+ALM AA + SV +LL GAD N + + T +G H
Sbjct: 112 WSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGH 156
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/76 (42%), Positives = 41/76 (53%), Gaps = 5/76 (6%)
Query: 135 DAALLEAARANNMQEVSRLLSE-GADVN-AKHRLGWTALMVAAINRNNSVVQVLLAAGAD 192
D L AA + + V RLL E GAD N A +GW+ LM+AA+ V Q L+ GA+
Sbjct: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
Query: 193 PNLGDDFSSVYKTAKE 208
P D S + KTA E
Sbjct: 251 P---DHLSVLEKTAFE 263
Score = 37.4 bits (85), Expect = 0.048
Identities = 26/66 (39%), Positives = 35/66 (53%), Gaps = 3/66 (4%)
Query: 133 NKDAA--LLEAARANNMQEVSRLLSEGADVNAKHRL-GWTALMVAAINRNNSVVQVLLAA 189
N D A L+ AA + V L+ ADV+ + + GWTALM A + N +V+ LL
Sbjct: 323 NGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382
Query: 190 GADPNL 195
GAD L
Sbjct: 383 GADVTL 388
Score = 31.2 bits (69), Expect = 3.5
Identities = 19/54 (35%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTAL-MVAAINRNNSVVQVLLAA 189
AL++A N + V LL++GADV + + G+TA +V +N ++ + LLA+
Sbjct: 363 ALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLAS 416
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 49.7 bits (117), Expect = 9e-06
Identities = 53/179 (29%), Positives = 76/179 (42%), Gaps = 18/179 (10%)
Query: 139 LEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD- 197
L+AA N + + L++G D NA +L TAL A + ++ +V LL AGA + D
Sbjct: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
Query: 198 -DFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLI-TREDDFN 255
D + V+ + GG + + NQ + P V + TR D
Sbjct: 176 LDRTPVFWACR---------GGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCL 226
Query: 256 NRL------NNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYARE 308
L N +G TALH AV Y+ +K LL GA RN TP+ AR+
Sbjct: 227 EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARD 285
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/191 (27%), Positives = 76/191 (39%), Gaps = 33/191 (17%)
Query: 116 CALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAA 175
CA ++ + S AL AA +++ V+ LL++GA++NA + AL AA
Sbjct: 97 CAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAA 156
Query: 176 INRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALE 235
+ VV +L+ GA+ D +H+ GQ +H+ N
Sbjct: 157 YMGHLDVVALLINHGAEVTCKDKKGYT-------PLHAAASNGQINVVKHLLN------- 202
Query: 236 FRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQR 295
GV I + + N TALH A V EL+D GAN Q
Sbjct: 203 --------LGVEIDEINVYGN-----------TALHIACYNGQDAVVNELIDYGANVNQP 243
Query: 296 NEMGHTPLDYA 306
N G TPL +A
Sbjct: 244 NNNGFTPLHFA 254
Score = 39.3 bits (90), Expect = 0.013
Identities = 53/219 (24%), Positives = 91/219 (41%), Gaps = 38/219 (17%)
Query: 153 LLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD-DFSSVYKTAKEQG- 210
L++ GADVN + + G + L + A++ + Q L+ G + + D D ++ A G
Sbjct: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH 326
Query: 211 ---IHSLEDGGQDGASRHITNQWTSAL-------EFRRWLGLPAGVLITREDDFNNRLNN 260
I++L G D A I + + L + R L L +G I D F +
Sbjct: 327 ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL-LSSGFEIDTPDKFGRTCLH 385
Query: 261 RASFKG--------------------C--TALHYAVLADDYRTVKELLDGGANPLQRNEM 298
A+ G C T LHYA + ++ L+ GAN + ++
Sbjct: 386 AAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDW 445
Query: 299 GHTPLDYAREGEVMK---LLRTSEAKYQEKQRKREAEER 334
G T L YA ++ + +L + +E +R RE +E+
Sbjct: 446 GRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEK 484
Score = 38.9 bits (89), Expect = 0.017
Identities = 41/164 (25%), Positives = 71/164 (43%), Gaps = 11/164 (6%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
AA N++ + L S GAD + K + G T L AA N + ++ L+ GA+ N DD+
Sbjct: 387 AAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWG 446
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITR---EDDFNNR 257
+TA S D + N + LE R L L ++D N
Sbjct: 447 ---RTALHYAAASDMDRNKTILGNAHDN--SEELERARELKEKEATLCLEFLLQNDANPS 501
Query: 258 LNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHT 301
+ ++ +G ++HYA + ++ LL+ + + ++ G T
Sbjct: 502 IRDK---EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
Score = 38.1 bits (87), Expect = 0.028
Identities = 48/190 (25%), Positives = 71/190 (37%), Gaps = 30/190 (15%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGA 191
S K L AA + + + L+ GA VNAK + T L A +R+ VQVL+ A
Sbjct: 14 SEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSA 73
Query: 192 DPNLGD-------DFSSVYKTAK--------EQGIHSLEDGGQDGASRHITNQWTSALEF 236
D N D ++ K K ++ + GG+ N +
Sbjct: 74 DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN- 132
Query: 237 RRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRN 296
L L G I D + R ALH+A V L++ GA ++
Sbjct: 133 ---LLLAKGANINAFDKKDRR-----------ALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 297 EMGHTPLDYA 306
+ G+TPL A
Sbjct: 179 KKGYTPLHAA 188
Score = 37.4 bits (85), Expect = 0.048
Identities = 42/176 (23%), Positives = 69/176 (39%), Gaps = 16/176 (9%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
AA + Q + LL D++ + G TAL +AA + V+ L+ GA + D+ +
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITN-----QWTSALEFRRWLGLPAGVLITREDDFN 255
K +H+ G R + + + + L V D +
Sbjct: 609 ------KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662
Query: 256 NRLNNRASFK-----GCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
L A+ GCTALH ++ V+ LL+ + L ++ G TPL YA
Sbjct: 663 LLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
Score = 35.8 bits (81), Expect = 0.14
Identities = 37/159 (23%), Positives = 67/159 (42%), Gaps = 13/159 (8%)
Query: 152 RLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDF--SSVYKTAKEQ 209
+LLS G +++ + G T L AA N +++L ++GAD + D + ++ A
Sbjct: 365 KLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANC 424
Query: 210 GIHSLEDGGQDGASRHITNQW-TSALEFRRWLGLPAG-VLITREDDFNNRLNNRASFKGC 267
H +E GA+ + T+ W +AL + + ++ D + L K
Sbjct: 425 HFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEK 484
Query: 268 TALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
A ++ LL ANP R++ G+ + YA
Sbjct: 485 EAT---------LCLEFLLQNDANPSIRDKEGYNSIHYA 514
Score = 32.7 bits (73), Expect = 1.2
Identities = 24/61 (39%), Positives = 34/61 (55%), Gaps = 1/61 (1%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLL-AAGADPNLG 196
L AA A++++ + LL A VNA G TALM+AA N V +L+ +A AD +
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVK 877
Query: 197 D 197
D
Sbjct: 878 D 878
>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
Length = 632
Score = 49.3 bits (116), Expect = 1e-05
Identities = 58/214 (27%), Positives = 93/214 (43%), Gaps = 30/214 (14%)
Query: 129 KSPSNKDAALLEAARANNMQE-VSRLLSEGADVNAKHR-LGWTALMVAAINRNNSVVQVL 186
+ P ++ LL A NN + V +S+GA V+ L T L A + S+V L
Sbjct: 84 RQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQL 143
Query: 187 LAAGADPNL--GDDFSSV-------------YKTAKEQGIHSLEDGGQDGASRHITNQWT 231
+ GADP+L G+ S + Y AK Q + ++ G W
Sbjct: 144 MKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPL------MWA 197
Query: 232 SALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGAN 291
+ +R P +L+T FN +N + TALH+AVLA + + LL+ GAN
Sbjct: 198 A---YRTHSVDPTRLLLT----FNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 250
Query: 292 PLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEK 325
+N G + LD A++ + + ++ + Q K
Sbjct: 251 VDAQNIKGESALDLAKQRKNVWMINHLQEARQAK 284
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 48.9 bits (115), Expect = 2e-05
Identities = 61/215 (28%), Positives = 90/215 (41%), Gaps = 19/215 (8%)
Query: 118 LAAALVVHCYSKSPSNKDA-ALLEAARANNMQEVSRLLSE-GADVNAKHRLGWTALMVAA 175
L A L+ H + ++D A L A N +RLL + GA V+A+ R GWT L +AA
Sbjct: 410 LCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469
Query: 176 INRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALE 235
N +V ++L++ ADPNL ++ + +H G + +T+Q
Sbjct: 470 QNNFENVARLLVSRQADPNL-------HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA 522
Query: 236 FRRWLGLPAGVLITRED--DFNNRLNNRA-----SFKGCTALHYAVLADDYRTVKELLDG 288
+R L P + + R + L + A G LH A Y K LL
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY 582
Query: 289 GANPLQRNEMGHTPLD---YAREGEVMKLLRTSEA 320
GA+ G TPL Y E++ LL S A
Sbjct: 583 GASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHA 617
Score = 45.1 bits (105), Expect = 2e-04
Identities = 50/188 (26%), Positives = 75/188 (39%), Gaps = 24/188 (12%)
Query: 133 NKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGAD 192
NK L ++++V LL+ DV+ + G+T L++AA ++ + +LLA GAD
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 193 PNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQ--WTSALEFRRWLGL-------- 242
N D+ +H G DG +R + + A E W L
Sbjct: 421 ANRVDEDGWA-------PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
Query: 243 --PAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH 300
A +L++R+ D N +G T LH A VK L GA +
Sbjct: 474 ENVARLLVSRQAD-----PNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528
Query: 301 TPLDYARE 308
TPL A E
Sbjct: 529 TPLHLAVE 536
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/81 (30%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
A + + V LL A+V+A++++GWT +AA+ N ++++VL+ AGA ++ D S
Sbjct: 666 AVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVS 725
Query: 201 ----SVYKTAKEQGIHSLEDG 217
+ +++QGI S +G
Sbjct: 726 CTPLQLALRSRKQGIMSFLEG 746
Score = 39.7 bits (91), Expect = 0.010
Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 37/193 (19%)
Query: 131 PSNKDAALLEAARANNMQEVSRLLSEG-ADVNAKHRLGWTALMVAAINRNNSVVQVLLAA 189
P+++ L A E+ LL+E A++ A + WT L +AA + +VV LL
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
Query: 190 GADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLIT 249
GADPN A++ G L H+ Q ++ L V+
Sbjct: 649 GADPN----------AAEQSGWTPL----------HLAVQRSTFL----------SVINL 678
Query: 250 REDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA--- 306
E N N+ G T H A L + +K L++ GA ++ + TPL A
Sbjct: 679 LEHHANVHARNKV---GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735
Query: 307 REGEVMKLLRTSE 319
R+ +M L E
Sbjct: 736 RKQGIMSFLEGKE 748
Score = 36.6 bits (83), Expect = 0.082
Identities = 57/230 (24%), Positives = 87/230 (37%), Gaps = 16/230 (6%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
A ++ + LL GA +A + G+ L AA + ++LL GA L
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
Query: 201 ------SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDF 254
+ YK E IH L + + + N L R L+ D
Sbjct: 594 WTPLHLAAYKGHLEI-IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD- 651
Query: 255 NNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR-EGEVMK 313
N A G T LH AV + +V LL+ AN RN++G TP A +G
Sbjct: 652 ----PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI 707
Query: 314 LLRTSEAKYQEKQRKREAEERRRFPLEQR---LKEHIIGQESAIATVGAA 360
L EA Q + + + L R + + G+E ++AT+G +
Sbjct: 708 LKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGS 757
Score = 35.8 bits (81), Expect = 0.14
Identities = 62/252 (24%), Positives = 91/252 (36%), Gaps = 41/252 (16%)
Query: 93 GPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDA-ALLEAARANNMQEVS 151
G + +D W + A G A L+ H ++ L A NN + V+
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 152 RLL-SEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGAD-----PNLGDDFSSVYKT 205
RLL S AD N G T L VAA + S+V++L + GA+ NL +
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
Query: 206 AKEQGI-HSLEDGG-----------------------------QDGASRHI-TNQWTSAL 234
K + I H L+ G + GAS + T+Q + L
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
Query: 235 EFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQ 294
+ G + + E N ++ T LH A + V LL GA+P
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNW---TPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 295 RNEMGHTPLDYA 306
+ G TPL A
Sbjct: 655 AEQSGWTPLHLA 666
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 48.9 bits (115), Expect = 2e-05
Identities = 25/59 (42%), Positives = 38/59 (64%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDF 199
+A + N + S L+ GA+VN K R G T LMVA +N + +VQ+LL GAD ++ ++F
Sbjct: 252 SAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEF 310
Score = 46.6 bits (109), Expect = 8e-05
Identities = 55/207 (26%), Positives = 87/207 (42%), Gaps = 23/207 (11%)
Query: 137 ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLG 196
AL+ AA+ + V L+S G DVN K+ G +LM+A + VV+ L GA
Sbjct: 147 ALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQAR 206
Query: 197 DDFSSVYKTAKEQGIHSLEDGG---------QDGASRHITNQ---WTSALEFRRWLGLPA 244
D +H DGG +DG + + WT + G
Sbjct: 207 DLGGCT-------ALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQR 259
Query: 245 GVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLD 304
+ + N + +R G T L AVL + V+ LLD GA+ +NE G L+
Sbjct: 260 VASLLIDAGANVNVKDR---NGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLE 316
Query: 305 YAREGEVMKLLRTSEAKYQEKQRKREA 331
AR + ++ E + ++KQR +++
Sbjct: 317 MARVFDRQSVVSLLEER-KKKQRPKKS 342
Score = 30.0 bits (66), Expect = 7.7
Identities = 18/54 (33%), Positives = 27/54 (50%)
Query: 133 NKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVL 186
N L+ A N+ + V LL +GAD + K+ G L +A + SVV +L
Sbjct: 277 NGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 48.9 bits (115), Expect = 2e-05
Identities = 46/185 (24%), Positives = 81/185 (43%), Gaps = 11/185 (5%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAA---GADPN 194
L++A + + + + ++ EG ++ ++ GW L AA ++VL A D
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 195 LGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFR---RWLGLPAGVLITRE 251
+ ++VY + L Q GA I+N+ ++ R +L+
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
Query: 252 DDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEV 311
D N+R N +G TALH +V +D ++ L+ GGA +N G TPL A +
Sbjct: 181 ADTNHRCN-----RGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQ 235
Query: 312 MKLLR 316
++ LR
Sbjct: 236 LEALR 240
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/177 (25%), Positives = 69/177 (38%), Gaps = 33/177 (18%)
Query: 130 SPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAA 189
S +++ L +A N + V L+ AD N + GWTAL + + V+Q+L++
Sbjct: 153 SNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG 212
Query: 190 GADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLIT 249
GA ++ GI L Q G AL F G
Sbjct: 213 GAK----------VESKNAYGITPLFVAAQSGQ--------LEALRFLAKYGA------- 247
Query: 250 REDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
D N + ++ AS AL+ A + V+ LL GA+ + N+ G PL A
Sbjct: 248 ---DINTQASDNAS-----ALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIA 296
Score = 37.0 bits (84), Expect = 0.063
Identities = 21/56 (37%), Positives = 33/56 (58%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLL 187
S+ +AL EA + + + V LLS+GAD N ++ G L +A+ N +VQ+LL
Sbjct: 254 SDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL 309
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/215 (26%), Positives = 89/215 (41%), Gaps = 21/215 (9%)
Query: 113 LGMCALAAALV-VHCYSKSPSNKDAALLEAARA--NNMQEVSRLLSEGADVNAKHRLGWT 169
LG A+A LV P++K L A N + L++ GADVN + + G +
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKS 308
Query: 170 ALMVAAINRNNSVVQVLLAAGADPNLGDDFSSV-----YKTAKEQGIHSLEDGGQDGASR 224
L +AAI+ + Q+L+ G++ + D F + + E I +L G D A R
Sbjct: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
Query: 225 HITNQWTSALEFRRWLG------LPAGVLITREDDFNNRLNNRASFK-------GCTALH 271
I + + L L +G L + +N A F G T LH
Sbjct: 369 GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLH 428
Query: 272 YAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYA 306
A + + LL GA+ +R++ G TPL YA
Sbjct: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/220 (27%), Positives = 94/220 (42%), Gaps = 41/220 (18%)
Query: 116 CALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAA 175
CA A A ++ + + + +AL A + +++ V+ LL++GA +N + L AA
Sbjct: 122 CAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAA 181
Query: 176 INRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQG-IHSLEDGGQDGASRHITNQWTSAL 234
+ V+++L+A GAD LG K K G +H+ GQ +
Sbjct: 182 FLGHLEVLKLLVARGAD--LG------CKDRKGYGLLHTAAASGQ--------------I 219
Query: 235 EFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQ 294
E ++L L G I + F N TALH A EL++ GAN Q
Sbjct: 220 EVVKYL-LRMGAEIDEPNAFGN-----------TALHIACYLGQDAVAIELVNAGANVNQ 267
Query: 295 RNEMGHTPLDYAREGE----VMKLL--RTSEAKYQEKQRK 328
N+ G TPL A ++LL ++ YQ K+ K
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK 307
Score = 44.7 bits (104), Expect = 3e-04
Identities = 53/181 (29%), Positives = 75/181 (41%), Gaps = 24/181 (13%)
Query: 138 LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGD 197
L AA + N + + LL+ ADVNA+ +L T L VAA NR + L + N+ D
Sbjct: 78 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137
Query: 198 DFSSVYKTAKEQGIHS--LEDGG---QDGASRHITNQ-------WTSALEFRRWLGLPAG 245
++A +HS LE GAS ++ ++ W + L L L
Sbjct: 138 RSG---RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL--- 191
Query: 246 VLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY 305
L+ R D + KG LH A + VK LL GA + N G+T L
Sbjct: 192 -LVARGADLGCK-----DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
Query: 306 A 306
A
Sbjct: 246 A 246
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/191 (30%), Positives = 83/191 (43%), Gaps = 36/191 (18%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFS 200
AA ++ + LL GA+VNAK L T L AA +RN V+ +LLA AD N D
Sbjct: 48 AAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARD--- 104
Query: 201 SVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNN 260
+++T +H A+ + + AL A +L + N
Sbjct: 105 KLWQTP----LHV--------AAANRATKCAEAL---------APLLSSL---------N 134
Query: 261 RASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR---EGEVMKLLRT 317
A G +ALH+AV + TV LL+ GA+ ++ PL +A EV+KLL
Sbjct: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
Query: 318 SEAKYQEKQRK 328
A K RK
Sbjct: 195 RGADLGCKDRK 205
Score = 38.9 bits (89), Expect = 0.017
Identities = 46/163 (28%), Positives = 63/163 (38%), Gaps = 31/163 (19%)
Query: 141 AARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAG-ADPNLGDDF 199
AA A+N+ + LL A+VNA G TALM AA N + V+ LL G AD + D+
Sbjct: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDE- 923
Query: 200 SSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLN 259
K +H G + + I + T++ N N
Sbjct: 924 ------NKNTALHLACSKGHEKCALMILAE-------------------TQDLGLINATN 958
Query: 260 NRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTP 302
+ LH A V+ LL GA L +E GHTP
Sbjct: 959 SALQM----PLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 38.5 bits (88), Expect = 0.022
Identities = 60/238 (25%), Positives = 91/238 (38%), Gaps = 40/238 (16%)
Query: 130 SPSNKDAALLEAARAN-NMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLA 188
+P N L AA + N++ ++ LLS GAD+ + + G T L AA N + L+
Sbjct: 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
Query: 189 AGADPNLGD----------DFSSVYKTA--------------------KEQGIHSLE--- 215
AGA N D S Y+ A +++ LE
Sbjct: 478 AGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLL 537
Query: 216 DGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVL 275
D G D + R Q +A+ + G + + E F N L + S + LH A
Sbjct: 538 DNGADPSLR--DRQGYTAVHYAAAYGNRQNLELLLEMSF-NCLEDVESTIPVSPLHLAAY 594
Query: 276 ADDYRTVKELLDGGANPLQRNEMGHTPLDYARE---GEVMKLLRTSEAKYQEKQRKRE 330
+K L + N R+ G T L A E E +++L A K+RKR+
Sbjct: 595 NGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
Score = 32.0 bits (71), Expect = 2.0
Identities = 20/63 (31%), Positives = 31/63 (49%)
Query: 125 HCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQ 184
H S + +D L E+ R + LL GAD + + R G+TA+ AA N ++
Sbjct: 508 HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLE 567
Query: 185 VLL 187
+LL
Sbjct: 568 LLL 570
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/103 (35%), Positives = 59/103 (57%), Gaps = 9/103 (8%)
Query: 121 ALVVHCYSKSPSN-KDA----ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAA 175
A+ + C KSP N KD LL A + + + LL GADVN++++ G TALM+A
Sbjct: 137 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 196
Query: 176 INRNNSVVQVLLAAGADPNLGDD--FSSVY--KTAKEQGIHSL 214
+++ V+ L+ GAD NL D +++++ K ++ GI SL
Sbjct: 197 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSL 239
Score = 32.7 bits (73), Expect = 1.2
Identities = 18/61 (29%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 128 SKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLL 187
S++ S + A +L A + V L+ +GAD+N LG+ AL + ++ N + +LL
Sbjct: 183 SRNKSGRTALML-ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 241
Query: 188 A 188
+
Sbjct: 242 S 242
Score = 31.6 bits (70), Expect = 2.6
Identities = 45/181 (24%), Positives = 70/181 (38%), Gaps = 7/181 (3%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSE-GADVNAKHRLGWTALMVAAINRNNSVVQVLLAAG 190
+ D LL+A + ++V+ LL + GA G TA +AA + ++V++ G
Sbjct: 20 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 79
Query: 191 ADPNLGD--DFSSVYKTAKEQGIHSLEDGGQDGA-SRHITNQWTSALEFRRWLGLPAGVL 247
D D S+++ AK + Q + + + +AL + G V
Sbjct: 80 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 139
Query: 248 ITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR 307
I E + N G L AV LLD GA+ RN+ G T L A
Sbjct: 140 ILCE---HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 196
Query: 308 E 308
E
Sbjct: 197 E 197
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/103 (35%), Positives = 59/103 (57%), Gaps = 9/103 (8%)
Query: 121 ALVVHCYSKSPSN-KDA----ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAA 175
A+ + C KSP N KD LL A + + + LL GADVN++++ G TALM+A
Sbjct: 126 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 185
Query: 176 INRNNSVVQVLLAAGADPNLGDD--FSSVY--KTAKEQGIHSL 214
+++ V+ L+ GAD NL D +++++ K ++ GI SL
Sbjct: 186 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSL 228
Score = 32.7 bits (73), Expect = 1.2
Identities = 18/61 (29%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 128 SKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLL 187
S++ S + A +L A + V L+ +GAD+N LG+ AL + ++ N + +LL
Sbjct: 172 SRNKSGRTALML-ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 230
Query: 188 A 188
+
Sbjct: 231 S 231
Score = 31.6 bits (70), Expect = 2.6
Identities = 45/181 (24%), Positives = 70/181 (38%), Gaps = 7/181 (3%)
Query: 132 SNKDAALLEAARANNMQEVSRLLSE-GADVNAKHRLGWTALMVAAINRNNSVVQVLLAAG 190
+ D LL+A + ++V+ LL + GA G TA +AA + ++V++ G
Sbjct: 9 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 68
Query: 191 ADPNLGD--DFSSVYKTAKEQGIHSLEDGGQDGA-SRHITNQWTSALEFRRWLGLPAGVL 247
D D S+++ AK + Q + + + +AL + G V
Sbjct: 69 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 128
Query: 248 ITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR 307
I E + N G L AV LLD GA+ RN+ G T L A
Sbjct: 129 ILCE---HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 185
Query: 308 E 308
E
Sbjct: 186 E 186
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/103 (35%), Positives = 59/103 (57%), Gaps = 9/103 (8%)
Query: 121 ALVVHCYSKSPSN-KDA----ALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAA 175
A+ + C KSP N KD LL A + + + LL GADVN++++ G TALM+A
Sbjct: 134 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 193
Query: 176 INRNNSVVQVLLAAGADPNLGDD--FSSVY--KTAKEQGIHSL 214
+++ V+ L+ GAD NL D +++++ K ++ GI SL
Sbjct: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSL 236
Score = 32.7 bits (73), Expect = 1.2
Identities = 18/61 (29%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 128 SKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLL 187
S++ S + A +L A + V L+ +GAD+N LG+ AL + ++ N + +LL
Sbjct: 180 SRNKSGRTALML-ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
Query: 188 A 188
+
Sbjct: 239 S 239
Score = 32.3 bits (72), Expect = 1.6
Identities = 48/190 (25%), Positives = 75/190 (39%), Gaps = 11/190 (5%)
Query: 127 YSKSPSNK----DAALLEAARANNMQEVSRLLSE-GADVNAKHRLGWTALMVAAINRNNS 181
+ KS +N+ D LL+A + ++V+ LL + GA G TA +AA +
Sbjct: 8 FRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVE 67
Query: 182 VVQVLLAAGADPNLGD--DFSSVYKTAKEQGIHSLEDGGQDGA-SRHITNQWTSALEFRR 238
++V++ G D D S+++ AK + Q + + + +AL +
Sbjct: 68 CLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAA 127
Query: 239 WLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEM 298
G V I E + N G L AV LLD GA+ RN+
Sbjct: 128 AQGCLQAVQILCE---HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKS 184
Query: 299 GHTPLDYARE 308
G T L A E
Sbjct: 185 GRTALMLACE 194
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,325,639
Number of Sequences: 37866
Number of extensions: 1316581
Number of successful extensions: 6933
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 273
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 4958
Number of HSP's gapped (non-prelim): 1588
length of query: 707
length of database: 18,247,518
effective HSP length: 109
effective length of query: 598
effective length of database: 14,120,124
effective search space: 8443834152
effective search space used: 8443834152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.